Sample records for trinity hiv control

  1. Multi-centre field evaluation of the performance of the Trinity Biotech Uni-Gold HIV 1/2 rapid test as a first-line screening assay for gay and bisexual men compared with 4th generation laboratory immunoassays.

    PubMed

    Keen, P; Conway, D P; Cunningham, P; McNulty, A; Couldwell, D L; Davies, S C; Smith, D E; Gray, J; Holt, M; O'Connor, C C; Read, P; Callander, D; Prestage, G; Guy, R

    2017-01-01

    The Trinity Biotech Uni-Gold HIV test (Uni-Gold) is often used as a supplementary rapid test in testing algorithms. To evaluate the operational performance of the Uni-Gold as a first-line screening test among gay and bisexual men (GBM) in a setting where 4th generation HIV laboratory assays are routinely used. We compared the performance of Uni-Gold with conventional HIV serology conducted in parallel among GBM attending 22 testing sites. Sensitivity was calculated separately for acute and established infection, defined using 4th generation screening Ag/Ab immunoassay (EIA) and Western blot results. Previous HIV testing history and results of supplementary 3rd generation HIV Ab EIA, and p24 antigen EIA were used to further characterise cases of acute infection. Of 10,793 specimens tested with Uni-Gold and conventional serology, 94 (0.90%, 95%CI:0.70-1.07) were confirmed as HIV-positive by conventional serology, and 37 (39.4%) were classified as acute infection. Uni-Gold sensitivity was 81.9% overall (77/94, 95%CI:72.6-89.1); 56.8% for acute infection (21/37, 95%CI:39.5-72.9) and 98.2% for established infection (56/57, 95%CI:90.6-100.0). Of 17 false non-reactive Uni-Gold results, 16 were acute infections, and of these seven were p24 antigen reactive but antibody negative. Uni-Gold specificity was 99.9% (10,692/10,699, 95%CI:99.9-100.0), PPV was 91.7% (95%CI:83.6-96.6) and NPV was 99.8% (95%CI:99.7-99.9), respectively. In this population, Uni-Gold had good specificity and sensitivity was high for established infections when compared to 4th generation laboratory assays, however sensitivity was lower in acute infections. Where rapid tests are used in populations with a high proportion of acute infections, additional testing strategies are needed to detect acute infections. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. FY17 CSSE L2 Milestone Report: Analyzing Power Usage Characteristics of Workloads Running on Trinity.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pedretti, Kevin

    This report summarizes the work performed as part of a FY17 CSSE L2 milestone to in- vestigate the power usage behavior of ASC workloads running on the ATS-1 Trinity plat- form. Techniques were developed to instrument application code regions of interest using the Power API together with the Kokkos profiling interface and Caliper annotation library. Experiments were performed to understand the power usage behavior of mini-applications and the SNL/ATDM SPARC application running on ATS-1 Trinity Haswell and Knights Landing compute nodes. A taxonomy of power measurement approaches was identified and presented, providing a guide for application developers to follow. Controlledmore » scaling study experiments were performed on up to 2048 nodes of Trinity along with smaller scale ex- periments on Trinity testbed systems. Additionally, power and energy system monitoring information from Trinity was collected and archived for post analysis of "in-the-wild" work- loads. Results were analyzed to assess the sensitivity of the workloads to ATS-1 compute node type (Haswell vs. Knights Landing), CPU frequency control, node-level power capping control, OpenMP configuration, Knights Landing on-package memory configuration, and algorithm/solver configuration. Overall, this milestone lays groundwork for addressing the long-term goal of determining how to best use and operate future ASC platforms to achieve the greatest benefit subject to a constrained power budget.« less

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    Trinity Gas Corp. officials signed an agreement on May 20, 1997, with the Cauca Valley Corp. (CVC) allowing Trinity to use CVC data to explore for natural gas in the Cauca Valley of Colombia. CVC, Colombia`s Valle del Cauca water resources and environmental division, is evaluating Colombia`s underground water reserves to protect, control and preserve fresh water aquifers, some of which contain natural gas pockets that cause blowouts in farmers` water wells. Preparations now are underway for drilling Trinity`s first well at the Palmira 1 site on the San Jose Hacienda, the largest privately owned sugar cane plantation in themore » valley. Trinity also entered into an agreement with the Cauca Valley Natural Gas and Electricity Project to furnish natural gas, generated electricity and energy fuel for the industrial district in the region. According to this contract, many valley residents will have electric service for the first time.« less

  4. Investigating Vertical Mixing Between Two Carbonate Aquifers Using a Multiport Well, Central Texas

    NASA Astrophysics Data System (ADS)

    Kromann, J.; Wong, C. I.; Hunt, B.; Smith, B.; Banner, J. L.

    2011-12-01

    Determining the occurrence and extent of mixing between vertically-adjacent aquifers is critical to dual-aquifer management. This can be challenging due to variable well depths and uncertainty as to hydrostratigraphic sources of groundwater. This study uses a multiport monitor well to investigate the degree of aquifer mixing between the overlying Edwards aquifer and underlying Trinity aquifer in central Texas. The results will inform dual-aquifer management as the Trinity aquifer is being developed as an alternative water source to the Edwards aquifer due to pumping limits and projections of increasing water demand. Water levels from isolated hydrostratigraphic units (n = 19) were measured monthly in the well as climate conditions transitioned from wet to dry (Sept 2010 to May 2011). Groundwater was sampled over a two-week interval in May to June 2011. At the start of the monitoring interval, water levels were high in the Edwards and the uppermost units of the Trinity relative to the rest of the Trinity units. Water levels decreased to lower elevations, from about 635 to 585 ft-msl, under dry conditions. Water levels in the lowermost Trinity declined less, from about 630 to 620 ft-msl, under dry conditions. Two zones separating the Edwards and lowermost Trinity showed almost no head change during this period. The water-level variations between the two aquifers suggest that: i) vertical flow potential from the Edwards to the Trinity occurs during dry conditions, ii) the uppermost stratigraphic units of the Trinity and Edwards are mixing, and iii) portions of the Trinity behave as an aquitard, providing hydrologic separation between the Edwards and lowermost Trinity units. Groundwater samples indicate the presence of three distinct hydrochemical facies: Ca-HCO3 (Edwards), Ca-HCO3-SO4 (lowermost Trinity), and Ca-SO4 (Trinity-Glen Rose Fm), suggesting little vertical flow and mixing. Covariation between groundwater 87Sr/86Sr values and SO4 concentrations from units of the Edwards and lowermost Trinity units can be accounted for by a two-end-member fluid mixing model, which uses a unit from the Edwards and lowermost Trinity as end members. This may indicate that 87Sr/86Sr values and SO4 concentrations are controlled by varying extents of mixing between the two units. Groundwater from units in the Glen Rose Formation (between the Edwards and lowermost Trinity units) cannot be accounted for by this mixing process due to elevated SO4 concentrations likely associated with dissolution of evaporites. 87Sr/86Sr values of evaporites recovered from the well are consistent with 87Sr/86Sr values of groundwater from these Glen Rose units. Although the geochemical model results suggest possible mixing between the Edwards and Trinity aquifers, water-level variations and the presence of distinct hydrochemical facies indicate that vertical flow between the Edwards and Trinity is limited to the uppermost units of the Trinity. This study suggests that the Edwards aquifer and lowermost Trinity units are not likely in hydrologic communication and independent management may be possible.

  5. The economic value of Trinity River water

    USGS Publications Warehouse

    Douglas, A.J.; Taylor, J.G.

    1999-01-01

    The Trinity River, largest tributary of the Klamath River, has its head-waters in the Trinity Alps of north-central California. After the construction of Trinity Dam in 1963, 90% of the Trinity River flow at Lewiston was moved to the Sacramento River via the Clear Creek Tunnel, a manmade conduit. Hydropower is produced at four installations along the route of Trinity River water that is diverted to the Sacramento River, and power production at three of these installations would diminish if no Trinity River water were diverted to the Sacramento River. After Trinity River water reaches the Sacramento River, it flows toward the Sacramento-San Joaquin Delta and San Francisco Bay. Trinity River water is pumped via Bureau of Reclamation canals and pumps to the northern San Joaquin Valley, where it is used for irrigated agriculture. The social cost of putting more water down the Trinity River is the sum of the value of the foregone consumer surplus from hydropower production as well as the value of the foregone irrigation water. Sharply diminished instream flows have also severely affected the size and robustness of Trinity River salmon, steelhead, shad and sturgeon runs. Survey data were used to estimate the non-market benefits of augmenting Trinity River instream flows by letting more water flow down the Trinity and moving less water to the Sacramento River. Preservation benefits for Trinity River instream flows and fish runs are $803 million per annum for the scenario that returns the most water down the Trinity River, a value that greatly exceeds the social cost estimate.The Trinity River, largest tributary of the Klamath River, has its headwaters in the Trinity Alps of north-central California. After the construction of Trinity Dam in 1963, 90% of the Trinity River flow at Lewiston was moved to the Sacramento River via the Clear Creek Tunnel, a manmade conduit. Hydropower is produced at four installations along the route of Trinity River water that is diverted to the Sacramento River, and power production at three of these installations would diminish if no Trinity River water were diverted to the Sacramento River. After Trinity River water reaches the Sacramento River, it flows toward the Sacramento-San Joaquin Delta and San Francisco Bay. Trinity River water is pumped via Bureau of Reclamation canals and pumps to the northern San Joaquin Valley, where it is used for irrigated agriculture. The social cost of putting more water down the Trinity River is the sum of the value of the foregone consumer surplus from hydropower production as well as the value of the foregone irrigation water. Sharply diminished instream flows have also severely affected the size and robustness of Trinity River salmon, steelhead, shad and sturgeon runs. Survey data were used to estimate the non-market benefits of augmenting Trinity River instream flows by letting more water flow down the Trinity and moving less water to the Sacramento River. Preservation benefits for Trinity River instream flows and fish runs are $803 million per annum for the scenario that returns the most water down the Trinity River, a value that greatly exceeds the social cost estimate.

  6. 12. View to southwest. View along centerline from Trinity County ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. View to southwest. View along centerline from Trinity County side of bridge. (90mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  7. LOOKING EASTSOUTHEAST. Showing downstream side of completed bridge, from confluence ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING EAST-SOUTHEAST. Showing downstream side of completed bridge, from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  8. Riverine based eco-tourism: Trinity River non-market benefits estimates

    USGS Publications Warehouse

    Douglas, A.J.; Taylor, J.G.

    1998-01-01

    California's Central Valley Project (CVP) was approved by voters in a statewide referendum in 1933. CVP referendum approval initiated funding for construction of important water development projects that had far reaching effects on regional water supplies. The construction of Trinity Dam in 1963 and the subsequent transbasin diversion of Trinity River flow was one of several CVP projects that had noteworthy adverse environmental and regional economic impacts. The Trinity River is the largest tributary of the Klamath River, and has its headwaters in the Trinity Alps of north-central California. After the construction of Trinity Dam in 1963, 90% of the Trinity River flow at Lewiston was moved to the Sacramento River via the Clear Creek Tunnel. Before 1963, the Trinity River was a major recreation resource of Northern California. The loss of streamflow has had a marked adverse impact on Trinity River-related recreation activities and the size and robustness of Trinity River salmon, steelhead, shad, and sturgeon runs. Trinity River water produces hydropower during its transit via Bureau of Reclamation canals and pumps to the northern San Joaquin Valley, where it is used for irrigated agriculture. The benefits provided by Trinity River instream flow-related environmental amenities were estimated with the travel cost method (TCM). Trinity River non-market benefits are about $406 million per annum, while the social cost of sending water down the Trinity River ranges from $17 to $42 million per annum, depending on the exact flow. We also discuss the relative magnitude of Trinity River survey data contingent value method (CVM) benefits estimates.

  9. COMPLETED STRUCTURE. View is eastsoutheast of downstream side of bridge, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COMPLETED STRUCTURE. View is east-southeast of downstream side of bridge, from beyond confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  10. 7. View to southeast. View of downstream side of bridge ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. View to southeast. View of downstream side of bridge from confluence of Trinity and South Fork Trinity Rivers. (90mm Lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  11. STEEL ERECTION. View of downstream of bridge, looking southeast from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    STEEL ERECTION. View of downstream of bridge, looking southeast from confluence of Trinity and South Fork Trinity rivers. The old suspension bridge is in background - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  12. Assessment of juvenile coho salmon movement and behavior in relation to rehabilitation efforts in the Trinity River, California, using PIT tags and radiotelemetry

    USGS Publications Warehouse

    Chase, Robert; Hemphill, Nina; Beeman, John; Juhnke, Steve; Hannon, John; Jenkins, Amy M.

    2013-01-01

    Coho salmon (Oncorhynchus kisutch) of the Southern Oregon/Northern California Coast (SONCC) Evolutionarily Significant Unit (ESU) is federally listed as a threatened species. The Trinity River Restoration Program (TRRP) is rehabilitating the Trinity River to restore coho salmon (coho) and other salmonid populations. In order to evaluate the program’s actions, several studies of movements and behavior of coho in the Trinity River were conducted from 2006 to 2009, including snorkel surveys and mark-recapture techniques based on Passive Integrated Transponder (PIT) tags, elastomer tags, and radio transmitters. Catch, recapture, and condition of natural sub-yearlings, along with site fidelity and emigration of hatchery-reared yearlings in rehabilitated and reference habitats, were studied. Location was important because coho were absent from the lower controlled and rehabilitated sites most of the time. However, rehabilitation did not have a significant effect on natural coho salmon at the site level. Apparent survival of radio-tagged, hatchery-reared yearling coho released downstream from Lewiston Dam was much lower in the first 10 km downstream from the release site than in other areas between Lewiston Dam and the Klamath River estuary. Estimated survival of yearling hatchery coho salmon per 100 km down to Blake’s Riffle was estimated at 64 % over the distance of the 239 km study area. Migration primarily occurred at night in the upper Trinity River; however, as yearlings moved through the lower Trinity River towards the Klamath River, estuary nocturnal migration became less. Apparent survival was generally lowest in areas upstream from the North Fork of the Trinity River.

  13. Impact. The southwest end is down, as the buckled middle ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Impact. The southwest end is down, as the buckled middle section splashes into the river. View is to southeast from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  14. Aftermath. The remains of the southwest end of the bridge ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aftermath. The remains of the southwest end of the bridge lie next to the southwest pier. View is south-southeast from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  15. Dust trailing from the top chord, the bridge falls toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Dust trailing from the top chord, the bridge falls toward the river, as the southwest end (right) falls first. View southeast from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  16. With water still in midflight, the northeast end of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    With water still in mid-flight, the northeast end of the bridge (left) nears total collapse. View is to southeast from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  17. Simulation of groundwater flow in the Edwards-Trinity and related aquifers in the Pecos County region, Texas

    USGS Publications Warehouse

    Thomas, Jonathan V.

    2014-01-01

    The Edwards-Trinity aquifer, a major aquifer in the Pecos County region of western Texas, is a vital groundwater resource for agricultural, industrial, and public supply uses. Resource managers would like to better understand the future availability of water in the Edwards-Trinity aquifer in the Pecos County region and the effects of the possible increase or temporal redistribution of groundwater withdrawals. To that end, the U.S. Geological Survey (USGS), in cooperation with the Middle Pecos Groundwater Conservation District, Pecos County, City of Fort Stockton, Brewster County, and Pecos County Water Control and Improvement District No. 1, completed a comprehensive, integrated analysis of available hydrogeologic data to develop a groundwater-flow model of the Edwards-Trinity and related aquifers in parts of Brewster, Jeff Davis, Pecos, and Reeves Counties. Following calibration, the model was used to evaluate the sustainability of recent (2008) and projected water-use demands on groundwater resources in the study area.

  18. With deck removed and critical members severed, the bridge begins ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    With deck removed and critical members severed, the bridge begins to succumb to tractors, pulling cables attached to its downstream side. View is to the southeast from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  19. Spray and dust hang in the air, as the demolition ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Spray and dust hang in the air, as the demolition is completed. Only the southeast pier remains standing at right. View is to southeast from confluence of Trinity and South Fork Trinity Rivers - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  20. 75 FR 47631 - Trinity Tank Car, Inc., a Subsidiary of Trinity Industries, Inc., Plants #19, 1200, 1017, 1110...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,065] Trinity Tank Car, Inc., a... workers of Trinity Tank Car, Inc., Plant 19, Longview, Texas. The notice was published in the Federal... findings, the Department is amending this certification to also include workers from Trinity Tank Car, Inc...

  1. Herpetological monitoring and assessment on the Trinity River, Trinity County, California—Final report

    USGS Publications Warehouse

    Snover, Melissa L.; Adams, Michael J.

    2016-06-14

    The primary goal of the Trinity River Restoration Program is to rehabilitate the fisheries on the dam-controlled Trinity River. However, maintaining and enhancing other wildlife populations through the restoration initiative is also a key objective. Foothill yellow-legged frogs (Rana boylii) and western pond turtles (Actinemys marmorata) have been identified as important herpetological species on which to focus monitoring efforts due to their status as California state-listed species of concern and potential listing on the U.S. Endangered Species List. We developed and implemented a monitoring strategy for these species specific to the Trinity River with the objectives of establishing baseline values for probabilities of site occupancy, colonization, and local extinction; identifying site characteristics that correlate with the probability of extinction; and estimating overall trends in abundance. Our 3-year study suggests that foothill yellow-legged frogs declined in the probability of site occupancy. Conversely, our results suggest that western pond turtles increased in both abundance and the probability of site occupancy. The short length of our study period makes it difficult to draw firm conclusions, but these results provide much-needed baseline data. Further monitoring and directed studies are required to assess how habitat changes and management decisions relate to the status and trend of these species over the long term.

  2. Water-quality assessment of the Trinity River basin, Texas : ground-water quality of the Trinity, Carrizo-Wilcox, and Gulf Coast aquifers, February-August 1994

    USGS Publications Warehouse

    Reutter, David C.; Dunn, David D.

    2000-01-01

    Ground-water samples were collected from wells in the outcrops of the Trinity, Carrizo-Wilcox, and Gulf Coast aquifers during February-August 1994 to determine the quality of ground water in the three major aquifers in the Trinity River Basin study unit, Texas. These samples were collected and analyzed for selected properties, nutrients, major inorganic constituents, trace elements, pesticides, dissolved organic carbon, total phenols, methylene blue active substances, and volatile organic compounds as part of the U.S. Geological Survey National Water-Quality Assessment Program. Quality-control practices included the collection and analysis of blank, duplicate, and spiked samples. Samples were collected from 12 shallow wells (150 feet or less) and from 12 deep wells (greater than 150 feet) in the Trinity aquifer, 11 shallow wells and 12 deep wells in the Carrizo-Wilcox aquifer, and 14 shallow wells and 10 deep wells in the Gulf Coast aquifer. The three aquifers had similar water chemistries-calcium was the dominant cation and bicarbonate the dominant anion. Statistical tests relating well depths to concentrations of nutrients and major inorganic constituents indicated correlations between well depth and concentrations of ammonia nitrogen, nitrite plus nitrate nitrogen, bicarbonate, sodium, and dissolved solids in the Carrizo-Wilcox aquifer and between well depth and concentrations of sulfate in the Gulf Coast aquifer. The tests indicated no significant correlations for the Trinity aquifer. Concentrations of dissolved solids were larger than the secondary maximum contaminant level of 500 milligrams per liter established for drinking water by the U.S. Environmental Protection Agency in 12 wells in the Trinity aquifer, 4 wells in the Carrizo-Wilcox aquifer, and 6 wells in the Gulf Coast aquifer. Iron concentrations were larger than the secondary maximum contaminant level of 300 micrograms per liter in at least 3 samples from each aquifer, and manganese concentrations were larger than the secondary maximum contaminant level of 50 micrograms per liter in at least 2 samples from each aquifer. The pesticides atrazine, deethylatrazine, and pp'-DDE were detected in at least one sample from each aquifer. Diazinon was detected in 11 Trinity aquifer samples and 4 Carrizo-Wilcox aquifer samples. Each aquifer had one detection of a volatile organic compound-benzene in the Trinity aquifer, trichlorofluoromethane in the Carrizo-Wilcox aquifer, and trichloromethane in the Gulf Coast aquifer.

  3. 76 FR 70751 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  4. 76 FR 52345 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  5. 75 FR 17158 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  6. 76 FR 14044 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  7. 75 FR 70947 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  8. 76 FR 23621 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  9. 75 FR 10501 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  10. 76 FR 34248 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  11. 75 FR 51284 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ...] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...

  12. Environmental and Cultural Resources within the Trinity River Basin

    DTIC Science & Technology

    1971-01-01

    Berimnopedia - Trinity River, Tarrant County (66) Hiorecyatia - Trinity River, Tarrant County (66) Oseillatoria - Trinity River, Tarrant County (66) Spirulina ...73, 74) have reported additional algae and fungi from North Texas waters. These species are listed below. Anabaena Anacystic Arthrospira Chroococcus

  13. PLANT AND PIER #2 EXCAVATION. View is to the northeast, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PLANT AND PIER #2 EXCAVATION. View is to the northeast, looking from Humboldt County side of river toward Trinity County side - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  14. POURING FOOTING OF PIER #1. View is to the southwest, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    POURING FOOTING OF PIER #1. View is to the southwest, looking from Pier 2 in Trinity County toward Pier 1 in Humboldt County - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  15. 77 FR 50155 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ...-FF08EACT00] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California...

  16. 77 FR 45370 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ...-FF08EACT00] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California...

  17. 77 FR 30314 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ...-FF08EACT00] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California...

  18. 77 FR 10766 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ...-FF08EACT00] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California...

  19. 77 FR 74203 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ...-FF08EACT00] Trinity Adaptive Management Working Group AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of meeting. SUMMARY: The Trinity Adaptive Management Working Group (TAMWG) affords stakeholders the opportunity to give policy, management, and technical input concerning Trinity River (California...

  20. OLD SUSPENSION BRIDGE. This view appears to be looking southeast, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    OLD SUSPENSION BRIDGE. This view appears to be looking southeast, at the downstream side of the suspension bridge, which was replaced by the South Fork Trinity River Bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  1. LOOKING EAST. View is to the northeast along centerline of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING EAST. View is to the northeast along centerline of deck, looking from Humboldt County toward Trinity County. The old suspension bridge is still in place at right - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  2. STARTING EXCAVATION PIER 2. This view is roughly northeast, with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    STARTING EXCAVATION PIER 2. This view is roughly northeast, with Pier 2 on the Trinity County end of the bridge. The old suspension bridge, at upper right, was upstream of new bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  3. Altitude of the water table in the alluvial and Wilcox aquifers in the vicinity of Richland and Tehuacana creeks and the Trinity River, Texas, December 1979

    USGS Publications Warehouse

    Garza, Sergio

    1980-01-01

    This map shows the altitude of the water table in the alluvial and Wilcox aquifers in the vicinity of Richland and Tehuacana Creeks and the Trinity River, Tex., in December 1979. The water-table contours were constructed on the basis of water-level control derived from an inventory of shallow wells in the area, topographic maps, and field locations of numerous small springs and seeps. (USGS)

  4. Geohydrologic Framework of the Edwards and Trinity Aquifers, South-Central Texas

    USGS Publications Warehouse

    Blome, Charles D.; Faith, Jason R.; Ozuna, George B.

    2007-01-01

    This five-year USGS project, funded by the National Cooperative Geologic Mapping Program, is using multidisciplinary approaches to reveal the surface and subsurface geologic architecture of two important Texas aquifers: (1) the Edwards aquifer that extends from south of Austin to west of San Antonio and (2) the southern part of the Trinity aquifer in the Texas Hill Country west and south of Austin. The project's principal areas of research include: Geologic Mapping, Geophysical Surveys, Geochronology, Three-dimensional Modeling, and Noble Gas Geochemistry. The Edwards aquifer is one of the most productive carbonate aquifers in the United States. It also has been designated a sole source aquifer by the U.S. Environmental Protection Agency and is the primary source of water for San Antonio, America's eighth largest city. The Trinity aquifer forms the catchment area for the Edwards aquifer and it intercepts some surface flow above the Edwards recharge zone. The Trinity may also contribute to the Edwards water budget by subsurface flow across formation boundaries at considerable depths. Dissolution, karst development, and faulting and fracturing in both aquifers directly control aquifer geometry by compartmentalizing the aquifer and creating unique ground-water flow paths.

  5. Geologic framework and hydrogeologic characteristics of the outcrops of the Edwards and Trinity aquifers, Medina Lake area, Texas

    USGS Publications Warehouse

    Small, Ted A.; Lambert, Rebecca B.

    1998-01-01

    The Trinity aquifer, which crops out in the northern part of the Medina Lake area and underlies the Edwards aquifer in the southern part, is much less permeable and productive than the Edwards aquifer. Where the Trinity aquifer underlies the Edwards, the Trinity acts as a lower confining unit on the Edwards.

  6. Development of a geodatabase for springs within and surrounding outcrops of the Trinity aquifer in northern Bexar County, Texas, 2010-11

    USGS Publications Warehouse

    Clark, Allan K.; Pedraza, Diane E.

    2013-01-01

    Data for 141 springs within and surrounding the Trinity aquifer outcrops in northern Bexar County were compiled from existing reports and databases. These data were augmented with selected data collected onsite, including the location, discharge, and water-quality characteristics of selected springs, and were entered into the geodatabase. The Trinity aquifer in central Texas is commonly divided into the upper, middle, and lower Trinity aquifers; all of the information that was compiled pertaining to the aquifer is for the upper and middle Trinity aquifers.

  7. CANVAS FINISH TO REMOVE FLOAT MARKS. View is to the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CANVAS FINISH TO REMOVE FLOAT MARKS. View is to the northwest of deck finishing operations - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  8. 14. View to southwest. View through truss along centerline from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. View to southwest. View through truss along centerline from below deck. (65mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  9. 20. View to southeast. Aerial view of bridge in setting; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. View to southeast. Aerial view of bridge in setting; downstream side. (135mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  10. COUNTERWEIGHT FOOTINGS ON EAST SIDE. View is to the north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COUNTERWEIGHT FOOTINGS ON EAST SIDE. View is to the north from the old suspension bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  11. 13. View to northeast. View along centerline from Humboldt County ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. View to northeast. View along centerline from Humboldt County side of bridge. (90mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  12. JIGGER STICK USED IN ERECTION. Shown on highline, direction of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    JIGGER STICK USED IN ERECTION. Shown on highline, direction of view is probably to the north - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  13. 11. View to southeast. More distant overview of bridge in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. View to southeast. More distant overview of bridge in setting; downstream side. (135mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  14. PIER 2. View is to the northeast, looking from Pier ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PIER 2. View is to the northeast, looking from Pier 1 toward Pier 2 from beneath completed bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  15. 3. View to southwest. Oblique view of downstream side of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. View to southwest. Oblique view of downstream side of bridge and west pier. (135mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  16. 2. View to east. Oblique view of downstream side of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. View to east. Oblique view of downstream side of bridge and east pier. (135mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  17. 9. View to northeast. Oblique view of upstream side of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. View to northeast. Oblique view of upstream side of bridge from approximately deck level. (90mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  18. PLACING TOP CHORD CENTER PANEL. View to the northwest from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PLACING TOP CHORD CENTER PANEL. View to the northwest from the old suspension bridge. Chord members in place - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  19. 17. View to west. Detail, connection point L2 (see plans), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. View to west. Detail, connection point L2 (see plans), from below deck. (135mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  20. Overview of the evolution of clay mineralogy in the Gulf of Mexico: implications for regional climate and drainage history of the Mississippi and Brazos-Trinity Rivers

    NASA Astrophysics Data System (ADS)

    Adatte, T.; John, C. M.; Flemings, P. B.; Behrmann, J.

    2005-12-01

    In this paper we present the overview and preliminary results of the analysis of clay minerals in two mini basins drilled during IODP Expedition 308. The goal of our project is to explore the vertical and temporal trends in clay mineralogy in the Ursa Basin and the Brazos-Trinity basin #4. The Brazos-Trinity basin was the sink for sands and clays carried by the Brazos and Trinity Rivers, while the Ursa basin was the sink for sediments carried by the Mississippi river. Reconstructing clay minerals (phyllosilicates <2μm in size) accumulations at these locations could thus potentially yield information on changes in the transport and the source of the siliclastic material transported in the course of the Pleistocene by these three rivers. Moreover, because the type of clay formed in soils through weathering processes largely depend on temperature and amount of precipitation, the dataset generated could provide clues on past climate changes. Some of the mechanisms that are hypothesized to play a major role in controlling clay accumulation in the basins investigated are reworking of clays on the American continent (controlled at the time-scale investigated here by changes in precipitation) and turbidity current deposition (controlled mainly by sea-level changes and thus glacio-eustasy). Finally, a major focusing point of Expedition 308 was sediment physical properties in an overpressured basin. Because each clay mineral specie has a specific average grain sizes, physical properties and cation exchange capacity, the clay mineral composition of the sediment investigated here (dominated by clay-sized particles) may partly control how these sediments react to changes in pressure and temperature. Thus, clay mineral data could contribute to our understanding of the physical properties of the sediments in overpressured basins, and collaborations with geotechnical scientist are planned.

  1. 15. View to northeast. View along centerline from below deck; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. View to northeast. View along centerline from below deck; detail of bent and floor beams. (65mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  2. STEEL ERECTION. View of upstream side of bridge, looking north ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    STEEL ERECTION. View of upstream side of bridge, looking north from the old suspension bridge at unjoined cantilever arms - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  3. 16. View to southsouthwest. Detail, connection point U1 (see plans), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. View to south-southwest. Detail, connection point U1 (see plans), from below deck. (135mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  4. LOWER CHORD ERECTION. View is to northnorthwest from the old ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOWER CHORD ERECTION. View is to north-northwest from the old suspension bridge. Chord members suspended from jigger stick - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  5. STEEL ERECTION. View is to the north from the old ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    STEEL ERECTION. View is to the north from the old suspension bridge, looking at upstream side of new bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  6. 4. View to westsouthwest. Oblique view of upstream side of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. View to west-southwest. Oblique view of upstream side of bridge from approximately deck level. (90mm lens) - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  7. Map Showing Geology and Hydrostratigraphy of the Edwards Aquifer Catchment Area, Northern Bexar County, South-Central Texas

    USGS Publications Warehouse

    Clark, Amy R.; Blome, Charles D.; Faith, Jason R.

    2009-01-01

    Rock units forming the Edwards and Trinity aquifers in northern Bexar County, Texas, are exposed within all or parts of seven 7.5-minute quadrangles: Bulverde, Camp Bullis, Castle Hills, Helotes, Jack Mountain, San Geronimo, and Van Raub. The Edwards aquifer is the most prolific ground-water source in Bexar County, whereas the Trinity aquifer supplies water for residential, commercial, and industrial uses for areas north of the San Antonio. The geologic map of northern Bexar County shows the distribution of informal hydrostratigraphic members of the Edwards Group and the underlying upper member of the Glen Rose Limestone. Exposures of the Glen Rose Limestone, which forms the Trinity aquifer alone, cover approximately 467 km2 in the county. This study also describes and names five informal hydrostratigraphic members that constitute the upper member of the Glen Rose Limestone; these include, in descending order, the Caverness, Camp Bullis, Upper evaporite, Fossiliferous, and Lower evaporite members. This study improves our understanding of the hydrogeologic connection between the two aquifers as it describes the geology that controls the infiltration of surface water and subsurface flow of ground water from the catchment area (outcropping Trinity aquifer rocks) to the Edwards water-bearing exposures.

  8. PLACING DIAGONALS IN CENTER PANEL. View is northnorthwest from the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PLACING DIAGONALS IN CENTER PANEL. View is north-northwest from the old suspension bridge, looking at upstream side of new bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  9. MOVING SHAFT FORMS FROM PIER #2 TO PIER #1. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MOVING SHAFT FORMS FROM PIER #2 TO PIER #1. View is to the northeast, with shaft forms being moved by highline - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  10. Identifying water-quality trends in the Trinity River, Texas, USA, 1969-1992, using sediment cores from Lake Livingston

    USGS Publications Warehouse

    Van Metre, P.C.; Callender, E.

    1996-01-01

    Chemical analyses were done on cores of bottom sediment from three locations in Lake Livingston, a reservoir on the Trinity River in east Texas to identify trends in water quality in the Trinity River using the chemical record preserved in bottom sediments trapped by the reservoir. Sediment cores spanned the period from 1969, when the reservoir was impounded, to 1992, when the cores were collected. Chemical concentrations in reservoir sediment samples were compared to concentrations for 14 streambed sediment samples from the Trinity River Basin and to reported concentrations for soils in the eastern United States and shale. These comparisons indicate that sediments deposited in Lake Livingston are representative of the environmental setting of Lake Livingston within the Trinity River Basin. Vertical changes in concentrations within sediment cores indicate temporal trends of decreasing concentrations of lead, sodium, barium, and total DDT (DDT plus its metabolites DDD and DDE) in the Trinity River. Possible increasing temporal trends are indicated for chlordane and dieldrin. Each sediment-derived trend is related to trends in water quality in the Trinity River or known changes in environmental factors in its drainage basin or both.

  11. COUNTERWEIGHT ON WEST SIDE. View is to the northwest of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    COUNTERWEIGHT ON WEST SIDE. View is to the northwest of counterweight on Humboldt County end of bridge, probably taken from the old suspension bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  12. PLACING TOP CHORD CENTER PANEL. View is to the northwest ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PLACING TOP CHORD CENTER PANEL. View is to the northwest from the old suspension bridge. Chord members being moved into place by jigger stick and highline - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  13. Simulations of flow in the Edwards-Trinity aquifer system and contiguous hydraulically connected units, west-central Texas

    USGS Publications Warehouse

    Kuniansky, E.L.; Holligan, K.Q.

    1994-01-01

    The transmissivity values used in the simulations were within estimated ranges and generally are: 1,000 to 10,000 ft2/d (feet squared per day) for the Edwards-Trinity and Trinity aquifers; 100,000 to greater than 1 million ft2/d for the Edwards aquifer; and less than 500 to 10,000 ft2/d in contiguous hydraulically connected units. Simulated flow through the Edwards-Trinity aquifer system and contiguous hydraulically connected units is about 3 million acre-feet per year. Estimates of areally distributed recharge from the simulations range from 0.1 to 1 inch per year for the Edwards-Trinity aquifer and increase to 4 inches per year for the Trinity aquifer. Recharge to the Edwards aquifer occurs along streambeds that cross outcropped high-permeability rocks of the Edwards Group through joints and faults. Many of the streams are diverted completely underground during periods of no precipitation. The movement of a substantial quantity of water (about 400 cubic feet per second) from the Trinity and Edwards-Trinity aquifers into the Edwards aquifer was simulated. Results of the simulations indicate that anisotropy strongly influences flow in the Edwards aquifer. In the San Antonio and Austin areas, the Edwards aquifer is the most active part of the ground-water flow system with one-third of ground-water discharge occurring in 5 percent of the modeled area for both simulations.

  14. 75 FR 34421 - Trinity County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ...) met at the Trinity County Office of Education in Weaverville, California, on June 7, 2010, at 6:30 p.m...: Trinity County Office of Education, 201 Memorial Drive, Weaverville, California 96093. FOR FURTHER....us . SUPPLEMENTARY INFORMATION: The meeting was open to the public. Public input sessions were...

  15. 78 FR 35312 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference and web-based meeting of the Trinity Adaptive Management Working Group (TAMWG). DATES: Public meeting, Teleconference, and web-based meeting: Tuesday June...

  16. 78 FR 49281 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference, and web-based meeting of the Trinity Adaptive Management Working Group (TAMWG). DATES: Public meeting, Teleconference, and web-based meeting: Tuesday...

  17. 78 FR 17226 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference and web-based meeting of the Trinity Adaptive Management Working Group (TAMWG). DATES: Public meeting, Teleconference, and web-based meeting: Monday April...

  18. 78 FR 46361 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Trinity Management Council (TMC). DATES: Public meeting, Teleconference, and web-based meeting: TAMWG and..., Douglas City, CA 96024. You may participate in person or by teleconference or web-based meeting from your...

  19. FY17 ASC CSSE L2 Milestone 6018: Power Usage Characteristics of Workloads Running on Trinity.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pedretti, Kevin

    The overall goal of this work was to utilize the Advanced Power Management (APM) capabilities of the ATS-1 Trinity platform to understand the power usage behavior of ASC workloads running on Trinity and gain insight into the potential for utilizing power management techniques on future ASC platforms.

  20. Estimated effects on water quality of Lake Houston from interbasin transfer of water from the Trinity River, Texas

    USGS Publications Warehouse

    Liscum, Fred; East, Jeffery W.

    2000-01-01

    The City of Houston is considering the transfer of water from the Trinity River to Lake Houston (on the San Jacinto River) to alleviate concerns about adequate water supplies for future water demands. The U.S. Geological Survey, in cooperation with the City of Houston, conducted a study to estimate the effects on the water quality of Lake Houston from the transfer of Trinity River water. A water-quality model, CE–QUAL–W2, was used to simulate six water-quality properties and constituents for scenarios of interbasin transfer of Trinity River water. Three scenarios involved the transferred Trinity River water augmenting streamflow in the East Fork of Lake Houston, and three scenarios involved the transferred water replacing streamflow from the West Fork of the San Jacinto River.The estimated effects on Lake Houston were determined by comparing volume-weighted daily mean water temperature, phosphorus, ammonia nitrogen, nitrite plus nitrate nitrogen, algal biomass, and dissolved oxygen simulated for each of the transfer scenarios to simulations for a base dataset. The effects of the interbasin transfer on Lake Houston do not appear to be detrimental to water temperature, ammonia nitrogen, or dissolved oxygen. Phosphorus and nitrite plus nitrate nitrogen showed fairly large changes when Trinity River water was transferred to replace West Fork San Jacinto River streamflow. Algal biomass showed large decreases when Trinity River water was transferred to augment East Fork Lake Houston streamflow and large increases when Trinity River water was transferred to replace West Fork San Jacinto River streamflow. Regardless of the scenario simulated, the model indicated that light was the limiting factor for algal biomass growth.

  1. (U) Status of Trinity and Crossroads Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Archer, Billy Joe; Lujan, James Westley; Hemmert, K. S.

    2017-01-10

    (U) This paper provides a general overview of current and future plans for the Advanced Simulation and Computing (ASC) Advanced Technology (AT) systems fielded by the New Mexico Alliance for Computing at Extreme Scale (ACES), a collaboration between Los Alamos Laboratory and Sandia National Laboratories. Additionally, this paper touches on research of technology beyond traditional CMOS. The status of Trinity, ASCs first AT system, and Crossroads, anticipated to succeed Trinity as the third AT system in 2020 will be presented, along with initial performance studies of the Intel Knights Landing Xeon Phi processors, introduced on Trinity. The challenges and opportunitiesmore » for our production simulation codes on AT systems will also be discussed. Trinity and Crossroads are a joint procurement by ACES and Lawrence Berkeley Laboratory as part of the Alliance for application Performance at EXtreme scale (APEX) http://apex.lanl.gov.« less

  2. 18. View to southwest. Detail, bearing shoe, upstream side of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. View to southwest. Detail, bearing shoe, upstream side of east pier. Copy negative made from 35mm color transparency made with with 135mm lens by John Snyder, due to lack of sufficiently long lens for 4x5 camera. - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

  3. SALMON-TRINITY ALPS WILDERNESS, CALIFORNIA.

    USGS Publications Warehouse

    Hotz, Preston E.; Thurber, Horace K.

    1984-01-01

    The Salmon-Trinity Alps Wilderness in the Klamath Mountains province occupies an area of about 648 sq mi in parts of Trinity, Siskiyou, and Humboldt Counties, northwestern California. As a result of field studies it was determined that the Salmon-Trinity Alps Wilderness has an area with substantiated potential for gold resources in known lode deposits. Small amounts of quicksilver have been produced from one mine but there is little promise for the discovery of additional mercury resources. Geochemical sampling showed that anomalously high amounts of several other metals occur in a few places, but there is little promise for the discovery of energy or mineral resources other than mercury and gold.

  4. Trinity to Trinity 1945-2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moniz, Ernest; Carr, Alan; Bethe, Hans

    The Trinity Test of July 16, 1945 was the first full-scale, real-world test of a nuclear weapon; with the new Trinity supercomputer Los Alamos National Laboratory's goal is to do this virtually, in 3D. Trinity was the culmination of a fantastic effort of groundbreaking science and engineering by hundreds of men and women at Los Alamos and other Manhattan Project sites. It took them less than two years to change the world. The Laboratory is marking the 70th anniversary of the Trinity Test because it not only ushered in the Nuclear Age, but with it the origin of today’s advancedmore » supercomputing. We live in the Age of Supercomputers due in large part to nuclear weapons science here at Los Alamos. National security science, and nuclear weapons science in particular, at Los Alamos National Laboratory have provided a key motivation for the evolution of large-scale scientific computing. Beginning with the Manhattan Project there has been a constant stream of increasingly significant, complex problems in nuclear weapons science whose timely solutions demand larger and faster computers. The relationship between national security science at Los Alamos and the evolution of computing is one of interdependence.« less

  5. Trinity to Trinity 1945-2015

    ScienceCinema

    Moniz, Ernest; Carr, Alan; Bethe, Hans; Morrison, Phillip; Ramsay, Norman; Teller, Edward; Brixner, Berlyn; Archer, Bill; Agnew, Harold; Morrison, John

    2018-01-16

    The Trinity Test of July 16, 1945 was the first full-scale, real-world test of a nuclear weapon; with the new Trinity supercomputer Los Alamos National Laboratory's goal is to do this virtually, in 3D. Trinity was the culmination of a fantastic effort of groundbreaking science and engineering by hundreds of men and women at Los Alamos and other Manhattan Project sites. It took them less than two years to change the world. The Laboratory is marking the 70th anniversary of the Trinity Test because it not only ushered in the Nuclear Age, but with it the origin of today’s advanced supercomputing. We live in the Age of Supercomputers due in large part to nuclear weapons science here at Los Alamos. National security science, and nuclear weapons science in particular, at Los Alamos National Laboratory have provided a key motivation for the evolution of large-scale scientific computing. Beginning with the Manhattan Project there has been a constant stream of increasingly significant, complex problems in nuclear weapons science whose timely solutions demand larger and faster computers. The relationship between national security science at Los Alamos and the evolution of computing is one of interdependence.

  6. Quality of water in the Trinity and Edwards aquifers, south-central Texas, 1996-98

    USGS Publications Warehouse

    Fahlquist, Lynne; Ardis, Ann F.

    2004-01-01

    During 1996–98, the U.S. Geological Survey studied surface- and ground-water quality in south-central Texas. The ground-water components included the upper and middle zones (undifferentiated) of the Trinity aquifer in the Hill Country and the unconfined part (recharge zone) and confined part (artesian zone) of the Edwards aquifer in the Balcones fault zone of the San Antonio region. The study was supplemented by information compiled from four ground-water-quality studies done during 1996–98.Trinity aquifer waters are more mineralized and contain larger dissolved solids, sulfate, and chloride concentrations compared to Edwards aquifer waters. Greater variability in water chemistry in the Trinity aquifer likely reflects the more variable lithology of the host rock. Trace elements were widely detected, mostly at small concentrations. Median total nitrogen was larger in the Edwards aquifer than in the Trinity aquifer. Ammonia nitrogen was detected more frequently and at larger concentrations in the Trinity aquifer than in the Edwards aquifer. Although some nitrate nitrogen concentrations in the Edwards aquifer exceeded a U.S. Geological Survey national background threshold concentration, no concentrations exceeded the U.S. Environmental Protection Agency public drinking-water standard.Synthetic organic compounds, such as pesticides and volatile organic compounds, were detected in the Edwards aquifer and less frequently in the Trinity aquifer, mostly at very small concentrations (less than 1 microgram per liter). These compounds were detected most frequently in urban unconfined Edwards aquifer samples. Atrazine and its breakdown product deethylatrazine were the most frequently detected pesticides, and trihalomethanes were the most frequently detected volatile organic compounds. Widespread detections of these compounds, although at small concentrations, indicate that anthropogenic activities affect ground-water quality.Radon gas was detected throughout the Trinity aquifer but not throughout the Edwards aquifer. Fourteen samples from the Trinity aquifer and 10 samples from the Edwards aquifer exceeded a proposed U.S. Environmental Protection Agency public drinking-water standard. Sources of radon in the study area might be granitic sediments underlying the Trinity aquifer and igneous intrusions in and below the Edwards aquifer.The presence of tritium in nearly all Edwards aquifer samples indicates that some component of sampled water is young (less than about 50 years), even for long flow paths in the confined zone. About one-half of the Trinity aquifer samples contained tritium, indicating that only part of the aquifer contains young water.Hydrogen and oxygen isotopes of water provide indicators of recharge sources to the Trinity and Edwards aquifers. Most ground-water samples have a meteorological isotopic signature indicating recharge as direct infiltration of water with little residence time on the land surface. Isotopic data from some samples collected from the unconfined Edwards aquifer indicate the water has undergone evaporation. At the time that ground-water samples were collected (during a drought), nearby streams were the likely sources of recharge to these wells.

  7. Quantifying downstream impacts of impoundment on flow regime and channel planform, lower Trinity River, Texas

    NASA Astrophysics Data System (ADS)

    Wellmeyer, Jessica L.; Slattery, Michael C.; Phillips, Jonathan D.

    2005-07-01

    As human population worldwide has grown, so has interest in harnessing and manipulating the flow of water for the benefit of humans. The Trinity River of eastern Texas is one such watershed greatly impacted by engineering and urbanization. Draining the Dallas-Fort Worth metroplex, just under 30 reservoirs are in operation in the basin, regulating flow while containing public supplies, supporting recreation, and providing flood control. Lake Livingston is the lowest, as well as largest, reservoir in the basin, a mere 95 km above the Trinity's outlet near Galveston Bay. This study seeks to describe and quantify channel activity and flow regime, identifying effects of the 1968 closure of Livingston dam. Using historic daily and peak discharge data from USGS gauging stations, flow duration curves are constructed, identifying pre- and post-dam flow conditions. A digital historic photo archive was also constructed using six sets of aerial photographs spanning from 1938 to 1995, and three measures of channel activity applied using a GIS. Results show no changes in high flow conditions following impoundment, while low flows are elevated. However, the entire post-dam period is characterized by significantly higher rainfall, which may be obscuring the full impact of flow regulation. Channel activity rates do not indicate a more stabilized planform following dam closure; rather they suggest that the Trinity River is adjusting itself to the stress of Livingston dam in a slow, gradual process that may not be apparent in a modern time scale.

  8. Community participation in fire management planning: The Trinity county fire safe council's fire plan

    Treesearch

    Yvonne Everett

    2008-01-01

    In 1999, Trinity County CA, initiated a participatory fire management planning effort. Since that time, the Trinity County Fire Safe Council has completed critical portions of a fire safe plan and has begun to implement projects defined in the plan. Completion of a GIS based, landscape scale fuels reduction element in the plan defined by volunteer fire fighters, agency...

  9. The Trinity River Greenway: A Prototype

    DTIC Science & Technology

    1972-06-01

    study have gone into the formulation of a multipurpose plan of management designed to tame the raging waters of the Trinity, subdue its flooding crests...TABLE 6 MAMMALS OF THE STUDY AREA Shorttail Shrew (Blarina brevicauda) Beaver (Castor canadensis) Least Shrew (Crytotis parva) Armadillo (Dasypjs...property resulted. The Trinity became an J :enemy, a raging torrent to be tamed and eventually subdued. Meanwhile, thoughful men began to realize that

  10. Bird monitoring as an aid to riparian restoration: Findings from the Trinity River in northwestern California

    Treesearch

    C. Klamath Bird Observatory and USFS Pacific Southwest Research Station

    2013-01-01

    The Trinity River Restoration Program began in 2000 with the goal of restoring the Trinity River's salmon and steelhead fisheries, which were severely degraded during the last half-century as a result of dams, water diversions under the Central Valley Project, and land-use practices such as gold mining. The restoration program, as outlined in the U.S. Department...

  11. Bedrock geology and hydrostratigraphy of the Edwards and Trinity aquifers within the Driftwood and Wimberley 7.5-minute quadrangles, Hays and Comal Counties, Texas

    USGS Publications Warehouse

    Clark, Allan K.; Morris, Robert R.

    2017-11-16

    The Edwards and Trinity aquifers are major sources of water in south-central Texas and are both classified as major aquifers by the State of Texas. The population in Hays and Comal Counties is rapidly growing, increasing demands on the area’s water resources. To help effectively manage the water resources in the area, refined maps and descriptions of the geologic structures and hydrostratigraphic units of the aquifers are needed. This report presents the detailed 1:24,000-scale bedrock hydrostratigraphic map as well as names and descriptions of the geologic and hydrostratigraphic units of the Driftwood and Wimberley 7.5-minute quadrangles in Hays and Comal Counties, Tex.Hydrostratigraphically, the rocks exposed in the study area represent a section of the upper confining unit to the Edwards aquifer, the Edwards aquifer, the upper zone of the Trinity aquifer, and the middle zone of the Trinity aquifer. In the study area, the Edwards aquifer is composed of the Georgetown Formation and the rocks forming the Edwards Group. The Trinity aquifer is composed of the rocks forming the Trinity Group. The Edwards and Trinity aquifers are karstic with high secondary porosity along bedding and fractures. The Del Rio Clay is a confining unit above the Edwards aquifer and does not supply appreciable amounts of water to wells in the study area.The hydrologic connection between the Edwards and Trinity aquifers and the various hydrostratigraphic units is complex because the aquifer system is a combination of the original Cretaceous depositional environment, bioturbation, primary and secondary porosity, diagenesis, and fracturing of the area from Miocene faulting. All of these factors have resulted in development of modified porosity, permeability, and transmissivity within and between the aquifers. Faulting produced highly fractured areas which allowed for rapid infiltration of water and subsequently formed solutionally enhanced fractures, bedding planes, channels, and caves that are highly permeable and transmissive. Because of faulting the juxtaposition of the aquifers and hydrostratigraphic units has resulted in areas of interconnectedness between the Edwards and Trinity aquifers and the various hydrostratigraphic units that form the aquifers.

  12. Characterization of streamflow, suspended sediment, and nutrients entering Galveston Bay from the Trinity River, Texas, May 2014–December 2015

    USGS Publications Warehouse

    Lucena, Zulimar; Lee, Michael T.

    2017-02-21

    The U.S. Geological Survey (USGS), in cooperation with the Texas Water Development Board and the Galveston Bay Estuary Program, collected streamflow and water-quality data at USGS streamflow-gaging stations in the lower Trinity River watershed from May 2014 to December 2015 to characterize and improve the current understanding of the quantity and quality of freshwater inflow entering Galveston Bay from the Trinity River. Continuous streamflow records at four USGS streamflow-gaging stations were compared to quantify differences in streamflow magnitude between upstream and downstream reaches of the lower Trinity River. Water-quality conditions were characterized from discrete nutrient and sedi­ment samples collected over a range of hydrologic conditions at USGS streamflow-gaging station 08067252 Trinity River at Wallisville, Tex. (hereinafter referred to as the “Wallisville site”), approximately 4 river miles upstream from where the Trinity River enters Galveston Bay.Based on streamflow records, annual mean outflow from Livingston Dam into the lower Trinity River was 2,240 cubic feet per second (ft3/s) in 2014 and 22,400 ft3/s in 2015, the second lowest and the highest, respectively, during the entire period of record (1966–2015). During this study, only about 54 percent of the total volume measured at upstream sites was accounted for at the Wallisville site as the Trinity River enters Galveston Bay. This difference in water volumes between upstream sites and the Wallisville site indicates that at high flows a large part of the volume released from Lake Livingston does not reach Galveston Bay through the main channel of the Trinity River. These findings indicate that water likely flows into wetlands and water bodies surrounding the main channel of the Trinity River before reaching the Wallisville site and is being stored or discharged through other channels that flow directly into Galveston Bay.To characterize suspended-sediment concentrations and loads in Trinity River inflow to Galveston Bay, a regression model was developed to estimate suspended-sediment concentrations by using acoustic backscatter data as a surrogate. The model yielded an adjusted coefficient of determination value of 0.92 and a root mean square error of 1.65 milligrams per liter (mg/L). The mean absolute percentage error between measured and estimated suspended-sediment concentration was 35 percent. During this study, estimated suspended-sediment concentrations ranged from 2 to 701 mg/L, with a mean of 97 mg/L. Suspended-sediment concentrations varied in response to changes in discharge, with peak suspended-sediment concentrations occurring 1 to 2 days before the peak discharge for each event. The total suspended-sediment load at the Wallisville site during May 2014–December 2015 was approximately 2,200,000 tons, with a minimum monthly suspended-sediment load of 100 tons in October 2014 and a maximum monthly load of 441,000 tons in November 2015.Results from nutrient samples collected at the Wallisville site indicate that total nitrogen and total phosphorus concen­trations fluctuated at a similar rate, with the highest nutrient concentrations occurring during periods of high flow corresponding to releases from Lake Livingston. The mean concen­trations of total nitrogen and total phosphorus were approxi­mately 75 percent higher during high flow releases than during periods of low flow, overshadowing variations in nutrient concentrations caused by seasonality at the Wallisville site.Results from the study indicate nutrient delivery to Galveston Bay from the main channel of the Trinity River is likely controlled primarily by high-flow releases from Lake Livingston. For most samples collected at the Wallisville site, organic nitrogen was the predominant form of nitrogen; however, when discharge increased because of releases from Lake Livingston, the percentage of organic nitrogen typically decreased and the percentage of nitrate increased. The concentrations of total phosphorus also increased during high-flow events, likely as a result of suspended sediment within Lake Livingston releases and mobilization of sediment particles in the river channel and flood plain during these periods of high flow. The predominant source of phosphorous to Galveston Bay from the Trinity River is in particulate form closely tied to suspended-sediment concentrations. The changes in nutrient concentration and composition caused by releases from Lake Livingston during this study indicate the reservoir may play an important role in the delivery of nutrients into Galveston Bay. Further study is required to better understand the processes in Lake Livingston influencing the characteristics of nutrient and sediment inflow to Galveston Bay. With phosphorous concentrations correlated to suspended-sediment concentra­tions (coefficient of determination value of 0.75) and with the concentrations of nutrients changing as the discharge changes, the diversion of water and suspended sediment into surround­ing wetlands and channels outside of the main channel of the Trinity River may play a large role in regulating nutrient inputs into Galveston Bay.

  13. A comparison of commercially available demineralized bone matrices with and without human mesenchymal stem cells in a rodent spinal fusion model.

    PubMed

    Hayashi, Tetsuo; Lord, Elizabeth L; Suzuki, Akinobu; Takahashi, Shinji; Scott, Trevor P; Phan, Kevin; Tian, Haijun; Daubs, Michael D; Shiba, Keiichiro; Wang, Jeffrey C

    2016-07-01

    OBJECTIVE The efficacy of some demineralized bone matrix (DBM) substances has been demonstrated in the spinal fusion of rats; however, no previous comparative study has reported the efficacy of DBM with human mesenchymal stem cells (hMSCs). There is an added cost to the products with stem cells, which should be justified by improved osteogenic potential. The purpose of this study is to prospectively compare the fusion rates of 3 different commercially available DBM substances, both with and without hMSCs. METHODS Posterolateral fusion was performed in 32 mature athymic nude rats. Three groups of 8 rats were implanted with 1 of 3 DBMs: Trinity Evolution (DBM with stem cells), Grafton (DBM without stem cells), or DBX (DBM without stem cells). A fourth group with no implanted material was used as a control group. Radiographs were obtained at 2, 4, and 8 weeks. The rats were euthanized at 8 weeks. Overall fusion was determined by manual palpation and micro-CT. RESULTS The fusion rates at 8 weeks on the radiographs for Trinity Evolution, Grafton, and DBX were 8 of 8 rats, 3 of 8 rats, and 5 of 8 rats, respectively. A significant difference was found between Trinity Evolution and Grafton (p = 0.01). The overall fusion rates as determined by micro-CT and manual palpation for Trinity Evolution, Grafton, and DBX were 4 of 8 rats, 3 of 8 rats, and 3 of 8 rats, respectively. The Trinity Evolution substance had the highest overall fusion rate, however no significant difference was found between groups. CONCLUSIONS The efficacies of these DBM substances are demonstrated; however, the advantage of DBM with hMSCs could not be found in terms of posterolateral fusion. When evaluating spinal fusion using DBM substances, CT analysis is necessary in order to not overestimate fusion.

  14. Fermi, Szilard and Trinity

    ERIC Educational Resources Information Center

    Anderson, Herbert L.

    1974-01-01

    The final installment of the author's recollections of his work with physicists Enrico Fermi, Leo Szilard and others in developing the first controlled nuclear chain reaction and in preparing the test explosion of the first atomic bomb. (GS)

  15. Diversifying natural resources value measurements: The Trinity River study

    USGS Publications Warehouse

    Taylor, J.G.; Douglas, A.J.

    1999-01-01

    An interdisciplinary team set out to establish the economic and social values of the Trinity River in northern California. This information was intended to support the Secretary of the Interior's decision on allocation of Trinity River flows. This team set out to measure the values of Trinity River flows, fishery resources, and recreation amenities in several different ways. A survey was mailed to users of the Trinity River. This single instrument included economic measures (willingness-to-pay and costs incurred in visiting) and social-psychological measures (importance, satisfaction, and water allocation preferences). A closely related survey measured several of these same values among west coast regional households. The results of these surveys were compiled, and the measured economic and social values were compared. We found that integrating economic and social value information provides a greater depth of understanding of the resource's value. In addition, this integration provides a more in-depth understanding through the quantitative and qualitative results that emerge.

  16. 75 FR 38143 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ........... 06/01/10 05/26/10 America (Workers). 74165 Trinity Tank Car Plant Longview, TX 06/01/10 05/26/10 1194 (State/One- Stop). 74166 Trinity Tank Car Plant Longview, TX 06/01/10 05/26/10 1110 (State/One- Stop). 74167 Trinity Tank Car Plant Longview, TX 06/01/10 05/26/10 17 (State/One- Stop). 74168 Kokomo Sanitary...

  17. Geologic framework and hydrostratigraphy of the Edwards and Trinity aquifers within northern Bexar and Comal Counties, Texas

    USGS Publications Warehouse

    Clark, Allan K.; Golab, James A.; Morris, Robert R.

    2016-11-28

    During 2014–16, the U.S. Geological Survey, in cooperation with the Edwards Aquifer Authority, documented the geologic framework and hydrostratigraphy of the Edwards and Trinity aquifers within northern Bexar and Comal Counties, Texas. The Edwards and Trinity aquifers are major sources of water for agriculture, industry, and urban and rural communities in south-central Texas. Both the Edwards and Trinity are classified as major aquifers by the State of Texas.The purpose of this report is to present the geologic framework and hydrostratigraphy of the Edwards and Trinity aquifers within northern Bexar and Comal Counties, Tex. The report includes a detailed 1:24,000-scale hydrostratigraphic map, names, and descriptions of the geology and hydrostratigraphic units (HSUs) in the study area.The scope of the report is focused on geologic framework and hydrostratigraphy of the outcrops and hydrostratigraphy of the Edwards and Trinity aquifers within northern Bexar and Comal Counties, Tex. In addition, parts of the adjacent upper confining unit to the Edwards aquifer are included.The study area, approximately 866 square miles, is within the outcrops of the Edwards and Trinity aquifers and overlying confining units (Washita, Eagle Ford, Austin, and Taylor Groups) in northern Bexar and Comal Counties, Tex. The rocks within the study area are sedimentary and range in age from Early to Late Cretaceous. The Miocene-age Balcones fault zone is the primary structural feature within the study area. The fault zone is an extensional system of faults that generally trends southwest to northeast in south-central Texas. The faults have normal throw, are en echelon, and are mostly downthrown to the southeast.The Early Cretaceous Edwards Group rocks were deposited in an open marine to supratidal flats environment during two marine transgressions. The Edwards Group is composed of the Kainer and Person Formations. Following tectonic uplift, subaerial exposure, and erosion near the end of Early Cretaceous time, the area of present-day south-central Texas was again submerged during the Late Cretaceous by a marine transgression resulting in deposition of the Georgetown Formation of the Washita Group.The Early Cretaceous Edwards Group, which overlies the Trinity Group, is composed of mudstone to boundstone, dolomitic limestone, argillaceous limestone, evaporite, shale, and chert. The Kainer Formation is subdivided into (bottom to top) the basal nodular, dolomitic, Kirschberg Evaporite, and grainstone members. The Person Formation is subdivided into (bottom to top) the regional dense, leached and collapsed (undivided), and cyclic and marine (undivided) members.Hydrostratigraphically the rocks exposed in the study area represent a section of the upper confining unit to the Edwards aquifer, the Edwards aquifer, the upper zone of the Trinity aquifer, and the middle zone of the Trinity aquifer. The Pecan Gap Formation (Taylor Group), Austin Group, Eagle Ford Group, Buda Limestone, and Del Rio Clay are generally considered to be the upper confining unit to the Edwards aquifer.The Edwards aquifer was subdivided into HSUs I to VIII. The Georgetown Formation of the Washita Group contains HSU I. The Person Formation of the Edwards Group contains HSUs II (cyclic and marine members [Kpcm], undivided), III (leached and collapsed members [Kplc,] undivided), and IV (regional dense member [Kprd]), and the Kainer Formation of the Edwards Group contains HSUs V (grainstone member [Kkg]), VI (Kirschberg Evaporite Member [Kkke]), VII (dolomitic member [Kkd]), and VIII (basal nodular member [Kkbn]).The Trinity aquifer is separated into upper, middle, and lower aquifer units (hereinafter referred to as “zones”). The upper zone of the Trinity aquifer is in the upper member of the Glen Rose Limestone. The middle zone of the Trinity aquifer is formed in the lower member of the Glen Rose Limestone, Hensell Sand, and Cow Creek Limestone. The regionally extensive Hammett Shale forms a confining unit between the middle and lower zones of the Trinity aquifer. The lower zone of the Trinity aquifer consists of the Sligo and Hosston Formations, which do not crop out in the study area.The upper zone of the Trinity aquifer is subdivided into five informal HSUs (top to bottom): cavernous, Camp Bullis, upper evaporite, fossiliferous, and lower evaporite. The middle zone of the Trinity aquifer is composed of the (top to bottom) Bulverde, Little Blanco, Twin Sisters, Doeppenschmidt, Rust, Honey Creek, Hensell, and Cow Creek HSUs. The underlying Hammett HSU is a regional confining unit between the middle and lower zones of the Trinity aquifer. The lower zone of the Trinity aquifer is not exposed in the study area.Groundwater recharge and flow paths in the study area are influenced not only by the hydrostratigraphic characteristics of the individual HSUs but also by faults and fractures and geologic structure. Faulting associated with the Balcones fault zone (1) might affect groundwater flow paths by forming a barrier to flow that results in water moving parallel to the fault plane, (2) might affect groundwater flow paths by increasing flow across the fault because of fracturing and juxtaposing porous and permeable units, or (3) might have no effect on the groundwater flow paths.The hydrologic connection between the Edwards and Trinity aquifers and the various HSUs is complex. The complexity of the aquifer system is a combination of the original depositional history, bioturbation, primary and secondary porosity, diagenesis, and fracturing of the area from faulting. All of these factors have resulted in development of modified porosity, permeability, and transmissivity within and between the aquifers. Faulting produced highly fractured areas that have allowed for rapid infiltration of water and subsequently formed solutionally enhanced fractures, bedding planes, channels, and caves that are highly permeable and transmissive. The juxtaposition resulting from faulting has resulted in areas of interconnectedness between the Edwards and Trinity aquifers and the various HSUs that form the aquifers.

  18. Water-quality assessment of the Trinity River Basin, Texas - Nutrients in two coastal prairie streams draining agricultural areas, 1994-95

    USGS Publications Warehouse

    Land, Larry F.

    1996-01-01

    In 1991, the U.S. Geological Survey (USGS) began nationwide implementation of the National Water-Quality Assessment (NAWQA) Program. Long-term goals of NAWQA are to describe the status of and trends in the quality of a large, representative part of the Nation?s surface- and ground-water resources and to provide a sound, scientific understanding of the primary natural and human factors affecting the quality of these resources (Leahy and others, 1990). The Trinity River Basin in east-central Texas (fig. 1) was among the first 20 hydrologic areas, called study units, to be assessed by this program. The first intensive data-collection phase for the Trinity River Basin NAWQA began in March 1993 and ended in September 1995. Streams in the Trinity River Basin were assessed by sampling water, bed sediment, and tissue of biota and characterizing the aquatic communities and their habitat. Aquifers were assessed by sampling water from wells. The coastal prairie is a small part of the Trinity River Basin, but it is environmentally important because of its proximity to Galveston Bay and the extensive use of agricultural chemicals on many irrigated farms. Galveston Bay (fig. 1) was selected by Congress as an estuary of national significance and was included on a priority list for the National Estuary Program. The Trinity River is especially important because its watershed dominates the total Galveston Bay drainage area and because its flow contributes substantial amounts of freshwater and water-quality constituents to the bay. Historically, measurements of the quantity and quality of water entering Galveston Bay from the Trinity River Basin have been made using data from a station about 113 kilometers (70 miles) upstream from Trinity Bay, an inlet bay to Galveston Bay. With a focused objective of providing additional water-quality information in the intervening coastal prairie area and an overall objective of improving the understanding of the relations between farming practices and stream quality in the Trinity River Basin, a special study was conducted. This report provides a description of the occurrence and concentrations of nutrients in two streams in this intervening area. An earlier report by Brown (1996) describes the occurrence and concentrations of pesticides in these two streams. An overall analysis of nutrient data collected during 1974?91 in the Trinity River Basin is given by Van Metre and Reutter (1995).

  19. Occurrence and distribution of fecal indicator bacteria, and physical and chemical indicators of water quality in streams receiving discharge from Dallas/Fort Worth International Airport and vicinity, North-Central Texas, 2008

    USGS Publications Warehouse

    Harwell, Glenn R.; Mobley, Craig A.

    2009-01-01

    This report, done by the U.S. Geological Survey in cooperation with Dallas/Fort Worth International (DFW) Airport in 2008, describes the occurrence and distribution of fecal indicator bacteria (fecal coliform and Escherichia [E.] coli), and the physical and chemical indicators of water quality (relative to Texas Surface Water Quality Standards), in streams receiving discharge from DFW Airport and vicinity. At sampling sites in the lower West Fork Trinity River watershed during low-flow conditions, geometric mean E. coli counts for five of the eight West Fork Trinity River watershed sampling sites exceeded the Texas Commission on Environmental Quality E. coli criterion, thus not fully supporting contact recreation. Two of the five sites with geometric means that exceeded the contact recreation criterion are airport discharge sites, which here means that the major fraction of discharge at those sites is from DFW Airport. At sampling sites in the Elm Fork Trinity River watershed during low-flow conditions, geometric mean E. coli counts exceeded the geometric mean contact recreation criterion for seven (four airport, three non-airport) of 13 sampling sites. Under low-flow conditions in the lower West Fork Trinity River watershed, E. coli counts for airport discharge sites were significantly different from (lower than) E. coli counts for non-airport sites. Under low-flow conditions in the Elm Fork Trinity River watershed, there was no significant difference between E. coli counts for airport sites and non-airport sites. During stormflow conditions, fecal indicator bacteria counts at the most downstream (integrator) sites in each watershed were considerably higher than counts at those two sites during low-flow conditions. When stormflow sample counts are included with low-flow sample counts to compute a geometric mean for each site, classification changes from fully supporting to not fully supporting contact recreation on the basis of the geometric mean contact recreation criterion. All water temperature measurements at sampling sites in the lower West Fork Trinity River watershed were less than the maximum criterion for water temperature for the lower West Fork Trinity segment. Of the measurements at sampling sites in the Elm Fork Trinity River watershed, 95 percent were less than the maximum criterion for water temperature for the Elm Fork Trinity River segment. All dissolved oxygen concentrations were greater than the minimum criterion for stream segments classified as exceptional aquatic life use. Nearly all pH measurements were within the pH criterion range for the classified segments in both watersheds, except for those at one airport site. For sampling sites in the lower West Fork Trinity River watershed, all annual average dissolved solids concentrations were less than the maximum criterion for the lower West Fork Trinity segment. For sampling sites in the Elm Fork Trinity River, nine of the 13 sites (six airport, three non-airport) had annual averages that exceeded the maximum criterion for that segment. For ammonia, 23 samples from 12 different sites had concentrations that exceeded the screening level for ammonia. Of these 12 sites, only one non-airport site had more than the required number of exceedances to indicate a screening level concern. Stormflow total suspended solids concentrations were significantly higher than low-flow concentrations at the two integrator sites. For sampling sites in the lower West Fork Trinity River watershed, all annual average chloride concentrations were less than the maximum annual average chloride concentration criterion for that segment. For the 13 sampling sites in the Elm Fork Trinity River watershed, one non-airport site had an annual average concentration that exceeded the maximum annual average chloride concentration criterion for that segment.

  20. Summary of Migration and Survival Data from Radio-Tagged Juvenile Coho Salmon in the Trinity River, Northern California, 2008

    USGS Publications Warehouse

    Beeman, John W.; Hansel, Hal; Juhnke, Steve; Stutzer, Greg

    2009-01-01

    The survival of hatchery-origin juvenile coho salmon from the Trinity River Hatchery was estimated as they migrated seaward through the Trinity and Klamath Rivers. The purpose of the study was to collect data for comparison to a similar study in the Klamath River and provide data to the Trinity River Restoration Program. A total of 200 fish fitted with radio transmitters were released into the Trinity River near the hatchery (river kilometer 252 from the mouth of the Klamath River) biweekly from March 19 to May 28, 2008. Fish from the earliest release groups took longer to pass the first detection site 10 kilometers downstream of the hatchery than fish from the later release groups, but travel times between subsequent sites were often similar among the release groups. The travel times of individuals through the 239 kilometer study area ranged from 15.5 to 84.6 days with a median of 43.3 days. The data and models did not support differences in survival among release groups, but did support differences among river reaches. The probability of survival in the first 53 kilometers was lower than in the reaches farther downstream, which is similar to trends in juvenile coho salmon in the Klamath River. The lowest estimated survival in this study was in the first 10 kilometers from release in the Trinity River (0.676 SE 0.036) and the highest estimated survival was in the final 20 kilometer reach in the Klamath River (0.987 SE 0.013). Estimated survivals of radio-tagged juvenile coho salmon from release to Klamath River kilometer 33 were 0.639 per 100 kilometers for Trinity River fish and 0.721 per 100 kilometers for Klamath River fish.

  1. Performance of VPIC on Trinity

    NASA Astrophysics Data System (ADS)

    Nystrom, W. D.; Bergen, B.; Bird, R. F.; Bowers, K. J.; Daughton, W. S.; Guo, F.; Li, H.; Nam, H. A.; Pang, X.; Rust, W. N., III; Wohlbier, J.; Yin, L.; Albright, B. J.

    2016-10-01

    Trinity is a new major DOE computing resource which is going through final acceptance testing at Los Alamos National Laboratory. Trinity has several new and unique architectural features including two compute partitions, one with dual socket Intel Haswell Xeon compute nodes and one with Intel Knights Landing (KNL) Xeon Phi compute nodes. Additional unique features include use of on package high bandwidth memory (HBM) for the KNL nodes, the ability to configure the KNL nodes with respect to HBM model and on die network topology in a variety of operational modes at run time, and use of solid state storage via burst buffer technology to reduce time required to perform I/O. An effort is in progress to port and optimize VPIC to Trinity and evaluate its performance. Because VPIC was recently released as Open Source, it is being used as part of acceptance testing for Trinity and is participating in the Trinity Open Science Program which has resulted in excellent collaboration activities with both Cray and Intel. Results of this work will be presented on performance of VPIC on both Haswell and KNL partitions for both single node runs and runs at scale. Work performed under the auspices of the U.S. Dept. of Energy by the Los Alamos National Security, LLC Los Alamos National Laboratory under contract DE-AC52-06NA25396 and supported by the LANL LDRD program.

  2. To provide for a land exchange with the Trinity Public Utilities District of Trinity County, California, involving the transfer of land to the Bureau of Land Management and the Six Rivers National Forest in exchange for National Forest System land in the Shasta-Trinity National Forest, and for other purposes.

    THOMAS, 112th Congress

    Rep. Herger, Wally [R-CA-2

    2011-03-29

    Senate - 07/24/2012 Received in the Senate and Read twice and referred to the Committee on Energy and Natural Resources. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  3. Floods in south-central Oklahoma and north-central Texas, October 1981

    USGS Publications Warehouse

    Buckner, Harold D.; Kurklin, Joanne K.

    1984-01-01

    Substantial reductions in peak stages and discharges on the West Fork Trinity River downstream from Eagle Mountain Reservoir were attained as a result of reservoir storage. All floodwater on the Elm Fork Trinity River was contained by reservoir storage thus preventing a potentially devastating flood downstream on the Trinity River. Maximum stages and discharges and/or contents were recorded during and after this major flood at 83 gaging stations, crest-stage stations, reservoir stations, and a miscellaneous site.

  4. Effects of water temperature on breeding phenology, growth and timing of metamorphosis of foothill yellow-legged frogs (Rana boylii) on the mainstem and selected tributaries of California's Trinity River - 2004-2009.

    Treesearch

    Clara Wheeler; James Bettaso; Donald Ashton; Hartwell Welsh

    2013-01-01

    The cold temperatures maintained in the Trinity River are beneficial to fish but may be problematic for foothill yellow-legged frogs. We examined the timing of breeding, reproductive output, and growth and development of tadpoles for populations of foothill yellow-legged frogs on the mainstem and six tributaries of the Trinity River. On the colder mainstem, onset of...

  5. Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania

    PubMed Central

    2009-01-01

    Background Suitable algorithms based on a combination of two or more simple rapid HIV assays have been shown to have a diagnostic accuracy comparable to double enzyme-linked immunosorbent assay (ELISA) or double ELISA with Western Blot strategies. The aims of this study were to evaluate the performance of five simple rapid HIV assays using whole blood samples from HIV-infected patients, pregnant women, voluntary counseling and testing attendees and blood donors, and to formulate an alternative confirmatory strategy based on rapid HIV testing algorithms suitable for use in Tanzania. Methods Five rapid HIV assays: Determine™ HIV-1/2 (Inverness Medical), SD Bioline HIV 1/2 3.0 (Standard Diagnostics Inc.), First Response HIV Card 1–2.0 (PMC Medical India Pvt Ltd), HIV1/2 Stat-Pak Dipstick (Chembio Diagnostic System, Inc) and Uni-Gold™ HIV-1/2 (Trinity Biotech) were evaluated between June and September 2006 using 1433 whole blood samples from hospital patients, pregnant women, voluntary counseling and testing attendees and blood donors. All samples that were reactive on all or any of the five rapid assays and 10% of non-reactive samples were tested on a confirmatory Inno-Lia HIV I/II immunoblot assay (Immunogenetics). Results Three hundred and ninety samples were confirmed HIV-1 antibody positive, while 1043 were HIV negative. The sensitivity at initial testing of Determine, SD Bioline and Uni-Gold™ was 100% (95% CI; 99.1–100) while First Response and Stat-Pak had sensitivity of 99.5% (95% CI; 98.2–99.9) and 97.7% (95% CI; 95.7–98.9), respectively, which increased to 100% (95% CI; 99.1–100) on repeat testing. The initial specificity of the Uni-Gold™ assay was 100% (95% CI; 99.6–100) while specificities were 99.6% (95% CI; 99–99.9), 99.4% (95% CI; 98.8–99.7), 99.6% (95% CI; 99–99.9) and 99.8% (95% CI; 99.3–99.9) for Determine, SD Bioline, First Response and Stat-Pak assays, respectively. There was no any sample which was concordantly false positive in Uni-Gold™, Determine and SD Bioline assays. Conclusion An alternative confirmatory HIV testing strategy based on initial testing on either SD Bioline or Determine assays followed by testing of reactive samples on the Determine or SD Bioline gave 100% sensitivity (95% CI; 99.1–100) and 100% specificity (95% CI; 96–99.1) with Uni-Gold™ as tiebreaker for discordant results. PMID:19226452

  6. Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania.

    PubMed

    Lyamuya, Eligius F; Aboud, Said; Urassa, Willy K; Sufi, Jaffer; Mbwana, Judica; Ndugulile, Faustin; Massambu, Charles

    2009-02-18

    Suitable algorithms based on a combination of two or more simple rapid HIV assays have been shown to have a diagnostic accuracy comparable to double enzyme-linked immunosorbent assay (ELISA) or double ELISA with Western Blot strategies. The aims of this study were to evaluate the performance of five simple rapid HIV assays using whole blood samples from HIV-infected patients, pregnant women, voluntary counseling and testing attendees and blood donors, and to formulate an alternative confirmatory strategy based on rapid HIV testing algorithms suitable for use in Tanzania. Five rapid HIV assays: Determine HIV-1/2 (Inverness Medical), SD Bioline HIV 1/2 3.0 (Standard Diagnostics Inc.), First Response HIV Card 1-2.0 (PMC Medical India Pvt Ltd), HIV1/2 Stat-Pak Dipstick (Chembio Diagnostic System, Inc) and Uni-Gold HIV-1/2 (Trinity Biotech) were evaluated between June and September 2006 using 1433 whole blood samples from hospital patients, pregnant women, voluntary counseling and testing attendees and blood donors. All samples that were reactive on all or any of the five rapid assays and 10% of non-reactive samples were tested on a confirmatory Inno-Lia HIV I/II immunoblot assay (Immunogenetics). Three hundred and ninety samples were confirmed HIV-1 antibody positive, while 1043 were HIV negative. The sensitivity at initial testing of Determine, SD Bioline and Uni-Gold was 100% (95% CI; 99.1-100) while First Response and Stat-Pak had sensitivity of 99.5% (95% CI; 98.2-99.9) and 97.7% (95% CI; 95.7-98.9), respectively, which increased to 100% (95% CI; 99.1-100) on repeat testing. The initial specificity of the Uni-Gold assay was 100% (95% CI; 99.6-100) while specificities were 99.6% (95% CI; 99-99.9), 99.4% (95% CI; 98.8-99.7), 99.6% (95% CI; 99-99.9) and 99.8% (95% CI; 99.3-99.9) for Determine, SD Bioline, First Response and Stat-Pak assays, respectively. There was no any sample which was concordantly false positive in Uni-Gold, Determine and SD Bioline assays. An alternative confirmatory HIV testing strategy based on initial testing on either SD Bioline or Determine assays followed by testing of reactive samples on the Determine or SD Bioline gave 100% sensitivity (95% CI; 99.1-100) and 100% specificity (95% CI; 96-99.1) with Uni-Gold as tiebreaker for discordant results.

  7. 75 FR 27814 - Trinity Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ..., 2010. ADDRESSES: The meeting will be held at the Trinity County Library, 211 Main St., Weaverville, CA... include discussion of the following topics: TRRP budget; Science program proposals and work plan...

  8. Trinity | Informatics Technology for Cancer Research (ITCR)

    Cancer.gov

    Trinity Cancer Transcriptome Analysis Toolkit (CTAT) including de novo transcriptome assembly with downstream support for expression analysis and focused analyses on cancer transcriptomes, incorporating mutation and fusion transcript discovery, and single cell analysis.

  9. 4. Photocopy of measured drawing (original in possession of Trinity ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of measured drawing (original in possession of Trinity Episcopal Cathedral) Edward Tuckerman Potter, architect ca. 1867 WEST FACADE, ELEVATION - Grace Episcopal Cathedral, 1121 Main Street, Davenport, Scott County, IA

  10. LLNL Mercury Project Trinity Open Science Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brantley, Patrick; Dawson, Shawn; McKinley, Scott

    2016-04-20

    The Mercury Monte Carlo particle transport code developed at Lawrence Livermore National Laboratory (LLNL) is used to simulate the transport of radiation through urban environments. These challenging calculations include complicated geometries and require significant computational resources to complete. As a result, a question arises as to the level of convergence of the calculations with Monte Carlo simulation particle count. In the Trinity Open Science calculations, one main focus was to investigate convergence of the relevant simulation quantities with Monte Carlo particle count to assess the current simulation methodology. Both for this application space but also of more general applicability, wemore » also investigated the impact of code algorithms on parallel scaling on the Trinity machine as well as the utilization of the Trinity DataWarp burst buffer technology in Mercury via the LLNL Scalable Checkpoint/Restart (SCR) library.« less

  11. A multiphased approach to groundwater investigations for the Edwards-Trinity and related aquifers in the Pecos County region, Texas

    USGS Publications Warehouse

    Thomas, Jonathan V.

    2014-01-01

    The Edwards-Trinity aquifer is a vital groundwater resource for agricultural, industrial, and public supply uses in the Pecos County region of western Texas. Resource managers would like to understand the future availability of water in the Edwards-Trinity aquifer in the Pecos County region and the effects of the possible increase or temporal redistribution of groundwater withdrawals. To provide resource managers with that information, the U.S. Geological Survey (USGS), in cooperation with the Middle Pecos Groundwater Conservation District, Pecos County, City of Fort Stockton, Brewster County, and Pecos County Water Control and Improvement District No. 1, completed a three-phase study of the Edwards-Trinity and related aquifers in parts of Brewster, Jeff Davis, Pecos, and Reeves Counties. The first phase was to collect groundwater, surface-water, geochemical, geophysical, and geologic data in the study area and develop a geodatabase of historical and collected data. Data compiled in the first phase of the study were used to develop the conceptual model in the second phase of the study. The third phase of the study involved the development and calibration of a numerical groundwater-flow model of the Edwards-Trinity aquifer to simulate groundwater conditions based on various groundwater-withdrawal scenarios. Analysis of well, geophysical, geochemical, and hydrologic data contributed to the development of the conceptual model in phase 1. Lithologic information obtained from well reports and geophysical data was used to describe the hydrostratigraphy and structural features of the groundwater-flow system, and aquifer-test data were used to estimate aquifer hydraulic properties. Geochemical data were used to evaluate groundwater-flow paths, water-rock interaction, aquifer interaction, and the mixing of water from different sources in phase 2. Groundwater-level data also were used to evaluate aquifer interaction, as well as to develop a potentiometric-surface map, delineate regional groundwater divides, and describe regional groundwater-flow paths. During phase 3, the data collected and compiled along with the conceptual information in the study area were incorporated into a numerical groundwater-flow model to evaluate the sustainability of recent (2008) and projected water-use demands on groundwater resources in the study area.

  12. Characterization of the world's first nuclear explosion, the Trinity test, as a source of public radiation exposure.

    PubMed

    Widner, Thomas E; Flack, Susan M

    2010-03-01

    The world's first atomic bomb was tested in New Mexico on 16 July 1945. From 1999 through 2008, scientists working for the Centers for Disease Control and Prevention gathered information relevant to past releases from Los Alamos activities, including the Trinity test. Detonation on a 30.5 m tower enhanced radioactive fallout, and terrain and wind patterns caused "hot spots" of deposition. Several ranchers reported that fallout resembling flour was visible for 4 to 5 d after the blast, and residents living as close as 19 km from ground zero collected rain water from metal roofs for drinking. Pressures to maintain secrecy and avoid legal claims led to decisions that would not likely have been made in later tests. Residents were not warned before the test or informed afterward about potential protective actions, and no evacuations were conducted. Occupied homes were overlooked on the day of the blast. Exposure rates in residential areas were recorded as high as 1.4 microC kg s (20 R h) using instruments that were crude, ill suited to field use, and incapable of effectively measuring alpha contamination from about 4.8 kg of unfissioned plutonium that was dispersed. Vehicle shielding and contamination were recognized but not corrected for. To date, the post-shot field team measurements have not been rigorously evaluated, cross-checked, adjusted, or subjected to uncertainty analysis. Evaluations of Trinity fallout published to date have not addressed internal doses to members of the public following intakes of contaminated air, water, or foods. The closing of these data gaps appears feasible with the information that has been assembled and would support placement of the Trinity event in perspective as a source of public radiation exposure and more defensible evaluation of the potential for human health effects.

  13. 5. Photocopy of measured drawing (original in possession of Trinity ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of measured drawing (original in possession of Trinity Episcopal Cathedral) Edward Tuckerman Potter, architect ca. 1867 CROSS SECTION, LOOKING NORTH - Grace Episcopal Cathedral, 1121 Main Street, Davenport, Scott County, IA

  14. Geologic history and hydrogeologic setting of the Edwards-Trinity aquifer system, west-central Texas

    USGS Publications Warehouse

    Barker, R.A.; Bush, P.W.; Baker, E.T.

    1994-01-01

    Because the diagenetic effects of cementation, recrystallization, and mineral replacement diminish the hydraulic conductivity of most rocks composing the Trinity and Edwards-Trinity aquifers, transmissivity values average less than 10,000 feet squared per day over more than 90 percent of the study area. However, the effects of tectonic fractures and dissolution in the Balcones fault zone cause transmissivity values to average about 750,000 feet squared per day in the Edwards aquifer, which occupies less than 10 percent of the study area.

  15. Use of watershed factors to predict consumer surfactant risk, water quality, and habitat quality in the upper Trinity River, Texas.

    PubMed

    Atkinson, S F; Johnson, D R; Venables, B J; Slye, J L; Kennedy, J R; Dyer, S D; Price, B B; Ciarlo, M; Stanton, K; Sanderson, H; Nielsen, A

    2009-06-15

    Surfactants are high production volume chemicals that are used in a wide assortment of "down-the-drain" consumer products. Wastewater treatment plants (WWTPs) generally remove 85 to more than 99% of all surfactants from influents, but residual concentrations are discharged into receiving waters via wastewater treatment plant effluents. The Trinity River that flows through the Dallas-Fort Worth metropolitan area, Texas, is an ideal study site for surfactants due to the high ratio of wastewater treatment plant effluent to river flow (>95%) during late summer months, providing an interesting scenario for surfactant loading into the environment. The objective of this project was to determine whether surfactant concentrations, expressed as toxic units, in-stream water quality, and aquatic habitat in the upper Trinity River could be predicted based on easily accessible watershed characteristics. Surface water and pore water samples were collected in late summer 2005 at 11 sites on the Trinity River in and around the Dallas-Fort Worth metropolitan area. Effluents of 4 major waste water treatment plants that discharge effluents into the Trinity River were also sampled. General chemistries and individual surfactant concentrations were determined, and total surfactant toxic units were calculated. GIS models of geospatial, anthropogenic factors (e.g., population density) and natural factors (e.g., soil organic matter) were collected and analyzed according to subwatersheds. Multiple regression analyses using the stepwise maximum R(2) improvement method were performed to develop prediction models of surfactant risk, water quality, and aquatic habitat (dependent variables) using the geospatial parameters (independent variables) that characterized the upper Trinity River watershed. We show that GIS modeling has the potential to be a reliable and inexpensive method of predicting water and habitat quality in the upper Trinity River watershed and perhaps other highly urbanized watersheds in semi-arid regions.

  16. Does Your Technology Support Measure Up?

    ERIC Educational Resources Information Center

    Abramson, Paul

    1998-01-01

    Provides tips on ways to keep computer systems in colleges and universities from failing while also controlling costs. Trinity College (Hartford) is used to illustrate how proper staffing, system maintenance, hardware purchasing decisions, technician compensation, and the use of students for maintenance work can effectively support a school's…

  17. Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015

    PubMed Central

    Williams, David J; Archer, Richard; Archibald, Peter; Bantounas, Ioannis; Baptista, Ricardo; Barker, Roger; Barry, Jacqueline; Bietrix, Florence; Blair, Nicholas; Braybrook, Julian; Campbell, Jonathan; Canham, Maurice; Chandra, Amit; Foldes, Gabor; Gilmanshin, Rudy; Girard, Mathilde; Gorjup, Erwin; Hewitt, Zöe; Hourd, Paul; Hyllner, Johan; Jesson, Helen; Kee, Jasmin; Kerby, Julie; Kotsopoulou, Nina; Kowalski, Stanley; Leidel, Chris; Marshall, Damian; Masi, Louis; McCall, Mark; McCann, Conor; Medcalf, Nicholas; Moore, Harry; Ozawa, Hiroki; Pan, David; Parmar, Malin; Plant, Anne L; Reinwald, Yvonne; Sebastian, Sujith; Stacey, Glyn; Thomas, Robert J; Thomas, Dave; Thurman-Newell, Jamie; Turner, Marc; Vitillo, Loriana; Wall, Ivan; Wilson, Alison; Wolfrum, Jacqueline; Yang, Ying; Zimmerman, Heiko

    2016-01-01

    This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this ‘may be difficult for cell-based medicinal products’. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates. PMID:27404768

  18. MANHATTAN: The View From Los Alamos of History's Most Secret Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carr, Alan Brady

    This presentation covers the political and scientific events leading up to the creation of the Manhattan Project. The creation of the Manhattan Project’s three most significant sites--Los Alamos, Oak Ridge, and Hanford--is also discussed. The lecture concludes by exploring the use of the atomic bombs at the end of World War II. The presentation slides include three videos. The first is a short clip of the 100-ton Test. The 100-Ton Test was history’s largest measured blast at that point in time; it was a pre-test for Trinity, the world’s first nuclear detonation. The second clip features views of Trinity followedmore » a short statement by the Laboratory’s first director, J. Robert Oppenheimer. The final clip shows Norris Bradbury talking about arms control.« less

  19. Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015.

    PubMed

    Williams, David J; Archer, Richard; Archibald, Peter; Bantounas, Ioannis; Baptista, Ricardo; Barker, Roger; Barry, Jacqueline; Bietrix, Florence; Blair, Nicholas; Braybrook, Julian; Campbell, Jonathan; Canham, Maurice; Chandra, Amit; Foldes, Gabor; Gilmanshin, Rudy; Girard, Mathilde; Gorjup, Erwin; Hewitt, Zöe; Hourd, Paul; Hyllner, Johan; Jesson, Helen; Kee, Jasmin; Kerby, Julie; Kotsopoulou, Nina; Kowalski, Stanley; Leidel, Chris; Marshall, Damian; Masi, Louis; McCall, Mark; McCann, Conor; Medcalf, Nicholas; Moore, Harry; Ozawa, Hiroki; Pan, David; Parmar, Malin; Plant, Anne L; Reinwald, Yvonne; Sebastian, Sujith; Stacey, Glyn; Thomas, Robert J; Thomas, Dave; Thurman-Newell, Jamie; Turner, Marc; Vitillo, Loriana; Wall, Ivan; Wilson, Alison; Wolfrum, Jacqueline; Yang, Ying; Zimmerman, Heiko

    2016-07-01

    This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this 'may be difficult for cell-based medicinal products'. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates.

  20. Urban Town and Gown: Increasing Minority Participation in the Geosciences Through a College-High School Partnership in Hartford, CT

    NASA Astrophysics Data System (ADS)

    OConnell, S.; OConnell, S.; OConnell, S.; Osborn, J. L.; Osborn, J. L.

    2001-12-01

    Urban public schools are often poor and have a tremendous need for educational assistance. In many cities the population is dominated by ethnic minorities. Hartford, CT, is one of these cities. Only about 50% of the students entering high school graduate and approximately 50% of those go on to higher education. Of those students taking the SAT's the average verbal and math scores are below 400. Despite these statistics, many students do succeed and therein lies an opportunity for earth scientists. As individuals and as institutions we can partner with schools and students to involve them in and excite them about the earth sciences. In 1995 Trinity College, located in Hartford, CT, undertook a \\$175 m.d. neighborhood revitalization project with funds from the college, neighboring institutions, foundations, and city, state and federal governments. Central to the revitalization is the "Learning Corridor," an educational complex that includes a magnet Montessori School, a Math and Science Middle School, and a Math and Science Magnet High School (GHAMAS). GHAMAS has a three-fold mission: teaching math and science to high school students, professional development for all math and science teachers from participating school districts, and community outreach. The Learning Corridor is adjacent to the Trinity College campus and Trinity faculty work with GHAMAS faculty to fulfill all three missions. Trinity faculty teach several high school classes. During the summer 3 Trinity and 1 GHAMAS faculty participated as a group in a week long-long NSF-sponsored Environmental Science workshop. This fall over ten teacher workshops were co-taught by Trinity and GHAMAS faculty. Recent NSF funding will allow us to develop a collaborative education and research program focused on the Connecticut River.

  1. Evaluation of median barrier safety issues.

    DOT National Transportation Integrated Search

    2008-01-01

    The objective of this study was to evaluate the effectiveness of the Brifen TL-4 and Trinity CASS median cable barrier systems in preventing cross-median collisions on sections of I-64, I-71, and I-265 (Brifen system) and I-265 (Trinity system) in Je...

  2. Analysis of Trinity Power Metrics for Automated Monitoring

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Michalenko, Ashley Christine

    This is a presentation from Los Alamos National Laboraotyr (LANL) about the analysis of trinity power metrics for automated monitoring. The following topics are covered: current monitoring efforts, motivation for analysis, tools used, the methodology, work performed during the summer, and future work planned.

  3. Ephemeral magma chambers in the Trinity peridotite, northern California

    NASA Astrophysics Data System (ADS)

    Cannat, Mathilde; Lécuyer, Christophe

    1991-02-01

    The Trinity Massif comprises the major lithologies of an ophiolite, as defined at the 1972 Penrose conference. Previous studies have shown, however, that it differs from the Semail (Oman) or Table Mountain (Newfoundland) ophiolitic massifs, particularly because its crustal section is thin, and because its mantle section has vertical plastic flow planes. These features have led to an interpretation of the Trinity Massif as a fragment of slow-spreading oceanic lithosphere (Le Sueur et al., 1984; Boudier and Nicolas, 1985). In this paper, we show that the Trinity gabbros occur in discontinuous, kilometre-sized pockets, intrusive into the mantle peridotites. The internal stratigraphy and the petrological characteristics of these gabbros suggest that they formed in short-lived magma chambers. These ephemeral magma chambers developed after the end of the plastic deformation in the surrounding mantle, when it had cooled down to lithospheric temperatures. We discuss the possibility that these small and ephemeral magma chambers formed at a slow-spreading oceanic ridge.

  4. Measurements of extinct fission products in nuclear bomb debris: Determination of the yield of the Trinity nuclear test 70 y later

    DOE PAGES

    Hanson, Susan Kloek; Pollington, Anthony Douglas; Waidmann, Christopher Russell; ...

    2016-07-05

    This study describes an approach to measuring extinct fission products that would allow for the characterization of a nuclear test at any time. The isotopic composition of molybdenum in five samples of glassy debris from the 1945 Trinity nuclear test has been measured. Nonnatural molybdenum isotopic compositions were observed, reflecting an input from the decay of the short-lived fission products 95Zr and 97Zr. By measuring both the perturbation of the 95Mo/ 96Mo and 97Mo/ 96Mo isotopic ratios and the total amount of molybdenum in the Trinity nuclear debris samples, it is possible to calculate the original concentrations of the 95Zrmore » and 97Zr isotopes formed in the nuclear detonation. Together with a determination of the amount of plutonium in the debris, these measurements of extinct fission products allow for new estimates of the efficiency and yield of the historic Trinity test.« less

  5. Measurements of extinct fission products in nuclear bomb debris: Determination of the yield of the Trinity nuclear test 70 y later

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hanson, Susan Kloek; Pollington, Anthony Douglas; Waidmann, Christopher Russell

    This study describes an approach to measuring extinct fission products that would allow for the characterization of a nuclear test at any time. The isotopic composition of molybdenum in five samples of glassy debris from the 1945 Trinity nuclear test has been measured. Nonnatural molybdenum isotopic compositions were observed, reflecting an input from the decay of the short-lived fission products 95Zr and 97Zr. By measuring both the perturbation of the 95Mo/ 96Mo and 97Mo/ 96Mo isotopic ratios and the total amount of molybdenum in the Trinity nuclear debris samples, it is possible to calculate the original concentrations of the 95Zrmore » and 97Zr isotopes formed in the nuclear detonation. Together with a determination of the amount of plutonium in the debris, these measurements of extinct fission products allow for new estimates of the efficiency and yield of the historic Trinity test.« less

  6. Measurements of extinct fission products in nuclear bomb debris: Determination of the yield of the Trinity nuclear test 70 y later

    PubMed Central

    Hanson, Susan K.; Pollington, Anthony D.; Waidmann, Christopher R.; Kinman, William S.; Wende, Allison M.; Miller, Jeffrey L.; Berger, Jennifer A.; Oldham, Warren J.; Selby, Hugh D.

    2016-01-01

    This paper describes an approach to measuring extinct fission products that would allow for the characterization of a nuclear test at any time. The isotopic composition of molybdenum in five samples of glassy debris from the 1945 Trinity nuclear test has been measured. Nonnatural molybdenum isotopic compositions were observed, reflecting an input from the decay of the short-lived fission products 95Zr and 97Zr. By measuring both the perturbation of the 95Mo/96Mo and 97Mo/96Mo isotopic ratios and the total amount of molybdenum in the Trinity nuclear debris samples, it is possible to calculate the original concentrations of the 95Zr and 97Zr isotopes formed in the nuclear detonation. Together with a determination of the amount of plutonium in the debris, these measurements of extinct fission products allow for new estimates of the efficiency and yield of the historic Trinity test. PMID:27382169

  7. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis.

    PubMed

    Haas, Brian J; Papanicolaou, Alexie; Yassour, Moran; Grabherr, Manfred; Blood, Philip D; Bowden, Joshua; Couger, Matthew Brian; Eccles, David; Li, Bo; Lieber, Matthias; MacManes, Matthew D; Ott, Michael; Orvis, Joshua; Pochet, Nathalie; Strozzi, Francesco; Weeks, Nathan; Westerman, Rick; William, Thomas; Dewey, Colin N; Henschel, Robert; LeDuc, Richard D; Friedman, Nir; Regev, Aviv

    2013-08-01

    De novo assembly of RNA-seq data enables researchers to study transcriptomes without the need for a genome sequence; this approach can be usefully applied, for instance, in research on 'non-model organisms' of ecological and evolutionary importance, cancer samples or the microbiome. In this protocol we describe the use of the Trinity platform for de novo transcriptome assembly from RNA-seq data in non-model organisms. We also present Trinity-supported companion utilities for downstream applications, including RSEM for transcript abundance estimation, R/Bioconductor packages for identifying differentially expressed transcripts across samples and approaches to identify protein-coding genes. In the procedure, we provide a workflow for genome-independent transcriptome analysis leveraging the Trinity platform. The software, documentation and demonstrations are freely available from http://trinityrnaseq.sourceforge.net. The run time of this protocol is highly dependent on the size and complexity of data to be analyzed. The example data set analyzed in the procedure detailed herein can be processed in less than 5 h.

  8. Concordant paleolatitudes for Neoproterozoic ophiolitic rocks of the Trinity Complex, Klamath Mountains, California

    USGS Publications Warehouse

    Mankinen, E.A.; Lindsley-Griffin, N.; Griffin, J.R.

    2002-01-01

    New paleomagnetic results from the eastern Klamath Mountains of northern California show that Neoproterozoic rocks of the Trinity ophiolitic complex and overlying Middle Devonian volcanic rocks are latitudinally concordant with cratonal North America. Combining paleomagnetic data with regional geologic and faunal evidence suggests that the Trinity Complex and related terranes of the eastern Klamath plate were linked in some fashion to the North American craton throughout that time, but that distance between them may have varied considerably. A possible model that is consistent with our paleomagnetic results and the geologic evidence is that the Trinity Complex formed and migrated parallel to paleolatitude in the basin between Laurasia and Australia-East Antarctica as the Rodinian supercontinent began to break up. It then continued to move parallel to paleolatitude at least through Middle Devonian time. Although the eastern Klamath plate served as a nucleus against which more western components of the Klamath Mountains province amalgamated, the Klamath superterrane was not accreted to North America until Early Cretaceous time.

  9. Sr-Nd isotopes constrain on the deposit history of the basins in the Gulf of Mexico

    NASA Astrophysics Data System (ADS)

    Li, Y.; Jiang, S.

    2015-12-01

    The Brazos-Trinity Basin IV and Ursa Basin are situated on the northern slope of the Gulf of Mexico. The Ursa basin lies in the center of late Pleistocene Mississippi River deposition, received the sediment deposition during Marine Isotope Stage (MIS) 2- 4. The Brazos-Trinity Basin IV belongs to a part of the Brazos-Trinity fan, it recorded the turbidite deposition and hemiplegic deposition during MIS1- 5. The Sr and Nd isotopic composition of the detrital composition of the sediment in both basins indicates the change of the sediment provenance during the basin-filled process. In the Ursa basin, The difference of 87Sr/86Sr ratio and ɛNd of the detrital component between MIS1,2 (87Sr/86Sr ~ 0.7219 - 0.7321, ɛNd ~ -12 - -13.4) and MIS3,4(87Sr/86Sr ~ 0.7310 - 0.7354, ɛNd ~ -16 - -17.9) is suggested to be related with the provenance change of the detrital particles since LGM. The addition of detrital particle from Appalachians with less radiogenic 87Sr/86Sr and positive ɛNd altered the character of the sediment of the Mississippi River during the last glaciation and deglaciation. In the Brazos-Trinity Basin IV, the narrow range of 87Sr/86Sr and ɛNd indicate that the sediment source of Brazos-Trinity Basin IV had not changed obviously during MIS5e to MIS2, mostly from coastal rivers such as Brazos River, Trinity River and Sabine River. The pre-fan with 87Sr/86Sr ~0.735 and ɛNd ~ -14.5 to -16.9, which is very similar to the deep sediment in the Ursa Basin with 87Sr/86Sr ~0.733 to 0.735 and ɛNd ~ -16 to -18. It is suggested that sediments of the pre-fan of the Brazos-Trinity Basin IV were supplied from the ancestral Mississippi River Delta during the low sea level (MIS 6). During the MIS5, the discharge of Mississippi River is thought switched to its present course, ~300 km to the east.

  10. 76 FR 44318 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... that the Commission received the following exempt wholesale generator filings: Docket Numbers: EG11-107-000. Applicants: Trinity Hills Wind Farm LLC. Description: Notice of Self-Certification of Exempt Wholesale Generator Status of Trinity Hills Wind Farm LLC. File Date: 07/15/2011. Accession Number: 20110715...

  11. 43 CFR 3583.4 - Hardrock mineral leases.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Hardrock mineral leases. 3583.4 Section... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.4 Hardrock mineral leases. ...

  12. 43 CFR 3583.4 - Hardrock mineral leases.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Hardrock mineral leases. 3583.4 Section... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.4 Hardrock mineral leases. ...

  13. 43 CFR 3583.4 - Hardrock mineral leases.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Hardrock mineral leases. 3583.4 Section... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.4 Hardrock mineral leases. ...

  14. 43 CFR 3583.4 - Hardrock mineral leases.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Hardrock mineral leases. 3583.4 Section... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.4 Hardrock mineral leases. ...

  15. Geologic framework, hydrostratigraphy, and ichnology of the Blanco, Payton, and Rough Hollow 7.5-minute quadrangles, Blanco, Comal, Hays, and Kendall Counties, Texas

    USGS Publications Warehouse

    Clark, Allan K.; Golab, James A.; Morris, Robert E.

    2016-09-13

    This report presents the geologic framework, hydro­stratigraphy, and ichnology of the Trinity and Edwards Groups in the Blanco, Payton, and Rough Hollow 7.5-minute quad­rangles in Blanco, Comal, Hays, and Kendall Counties, Texas. Rocks exposed in the study area are of the Lower Cretaceous Trinity Group and lower part of the Fort Terrett Formation of the Lower Cretaceous Edwards Group. The mapped units in the study area are the Hammett Shale, Cow Creek Limestone, Hensell Sand, and Glen Rose Limestone of the Trinity Group and the lower portion of the Fort Terrett Formation of the Edwards Group. The Glen Rose Limestone is composed of the Lower and Upper Members. These Trinity Group rocks con­tain the upper and middle Trinity aquifers. The only remaining outcrops of the Edwards Group are the basal nodular member of the Fort Terrett Formation, which caps several hills in the northern portion of the study area. These rocks were deposited in an open marine to supratidal flats environment. The faulting and fracturing in the study area are part of the Balcones fault zone, an extensional system of faults that generally trends southwest to northeast in south-central Texas.The hydrostratigraphic units of the Edwards and Trinity aquifers were mapped and described using a classification system based on fabric-selective or not-fabric-selective poros­ity types. The only hydrostratigraphic unit of the Edwards aquifer present in the study area is hydrostratigraphic unit VIII. The mapped hydrostratigraphic units of the upper Trinity aquifer are (from top to bottom) the Camp Bullis, upper evaporite, fossiliferous, and lower evaporite which are interval equivalent to the Upper Member of the Glen Rose Limestone. The middle Trinity aquifer encompasses (from top to bottom) the Lower Member of the Glen Rose Limestone, the Hensell Sand Member, and the Cow Creek Limestone Member of the Pearsall Formation. The Lower Member of the Glen Rose Limestone is subdivided into six informal hydro­stratigraphic units (from top to bottom) the Bulverde, Little Blanco, Twin Sisters, Doeppenschmidt, Rust, and Honey Creek hydrostratigraphic units.This study used the ichnofabric index scale to interpret the amount of bioturbation in the field. Most of the geologic units in the study area are assigned to the Cruziana and Thalassinoides ichnofacies consistent with interpretations of a tidal-dominated open marine environment (sublittoral zone). Ichnofossil assemblages are dominated by Thalassinoides networks, but also contain Cruziana, Ophiomorpha, Paleo­phycus, Planolites, and Serpulid traces.

  16. The Case of Trinity University: Collegial Rift, Mission Drift, Corporate Shift

    ERIC Educational Resources Information Center

    Twale, Darla J.; Place, A. William

    2006-01-01

    The case of Trinity University is an ideal way to introduce graduate students in educational leadership preparation programs to the university culture and how it shapes the graduate curriculum, faculty expectations for student outcomes, and professional socialization processes. Master's and doctoral students who take courses related to cultural…

  17. 75 FR 6791 - Surety Companies Acceptable on Federal Bonds-Termination: Trinity Universal Insurance Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... DEPARTMENT OF THE TREASURY Fiscal Service Surety Companies Acceptable on Federal Bonds--Termination: Trinity Universal Insurance Company AGENCY: Financial Management Service, Fiscal Service... that the Certificate of Authority issued by the Treasury to the above-named company under 31 U.S.C...

  18. 76 FR 30902 - Shasta Lake Management Unit, Shasta-Trinity National Forest; California; Green-Horse Habitat...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... management strategy to allow modification of treatments if necessary during implementation. A project-level... to 15 tons per acre for those two management prescriptions. This project-level amendment is proposed... Management Unit, Shasta-Trinity National Forest; California; Green-Horse Habitat Restoration and Maintenance...

  19. 76 FR 4365 - Renewal of the Trinity River Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Management Working Group AGENCY: Office of the Secretary, Interior. ACTION: Notice. SUMMARY: The Secretary of... Trinity River Adaptive Management Working Group (Working Group) for 2 years. The Working Group provides... Road, Arcata, CA 95521; 707-822-7201. SUPPLEMENTARY INFORMATION: The Working Group conducts its...

  20. 78 FR 5830 - Renewal of the Trinity River Adaptive Management Working Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... Management Working Group AGENCY: Office of the Secretary, Interior. ACTION: Notice. SUMMARY: The Secretary of... Trinity River Adaptive Management Working Group (Working Group) for 2 years. The Working Group provides... Road, Arcata, CA 95521; 707-822-7201. SUPPLEMENTARY INFORMATION: The Working Group conducts its...

  1. Simulating sediment loading into the major reservoirs in Trinity River Basin

    USDA-ARS?s Scientific Manuscript database

    The Upper Trinity Basin supplies water to about one-fourth of Texas' population. The anticipated rapid growth of North Central Texas will certainly increase regional demands for high quality drinking water. This has increased concerns that sediment and nutrient loads received by drinking water reser...

  2. A program to assess a thermal discharge on Trinity Bay, Texas

    NASA Technical Reports Server (NTRS)

    Zaitzeff, J. B.; Whitehead, V. S.

    1972-01-01

    The application of a two dimensional mathematical model to the analysis of the thermal discharge to verify its ability to predict the temperature distribution of Trinity Bay in the vicinity of the water outfall. Basic data consist of aerial thermal infrared and in situ measurements.

  3. 43 CFR 3583.1-1 - Leasable minerals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Leasable minerals. 3583.1-1 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-1 Leasable minerals. Except as otherwise...

  4. 43 CFR 3583.1-2 - Hardrock minerals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Hardrock minerals. 3583.1-2 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-2 Hardrock minerals. This subpart governs the...

  5. 43 CFR 3583.1-2 - Hardrock minerals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Hardrock minerals. 3583.1-2 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-2 Hardrock minerals. This subpart governs the...

  6. 43 CFR 3583.1-2 - Hardrock minerals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Hardrock minerals. 3583.1-2 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-2 Hardrock minerals. This subpart governs the...

  7. 43 CFR 3583.1-1 - Leasable minerals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Leasable minerals. 3583.1-1 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-1 Leasable minerals. Except as otherwise...

  8. 43 CFR 3583.1-1 - Leasable minerals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Leasable minerals. 3583.1-1 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-1 Leasable minerals. Except as otherwise...

  9. 43 CFR 3583.1-1 - Leasable minerals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Leasable minerals. 3583.1-1 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-1 Leasable minerals. Except as otherwise...

  10. 43 CFR 3583.1-2 - Hardrock minerals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Hardrock minerals. 3583.1-2 Section 3583.1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS Shasta and Trinity Units of the Whiskeytown-Shasta-Trinity National Recreation Area § 3583.1-2 Hardrock minerals. This subpart governs the...

  11. Numerical Modeling of Trinity River Shoaling below Wallisville, Texas

    DTIC Science & Technology

    2015-02-01

    levees , the hydraulic deltaic process of finding the most efficient pathway to open water controls the flow direction and speed. Additionally, changes...events to allow flow to pass through the structures. During the dry season the structures are normally closed to control salt water intrusion. The... levees and natural ridges, which have low spots and channels that have incised from previous floods. Second, once the flood waters are outside the

  12. Trinity's "Legal Detectives" Stalk Jack the Ripper: Would Socrates Have Approved?

    ERIC Educational Resources Information Center

    Mangan, Katherine S.

    1989-01-01

    Trinity University's philosophy laboratory provides a think tank for philosophy students, allowing them to practice such skills as logic, critical reasoning, and the application of moral responsibility in decision-making by applying their skills to real-life situations. Students, selected as fellows and paid, are divided into teams for projects.…

  13. Certificated Master Contract Agreement for 1987-90, Shasta-Tehama-Trinity Joint Community College District.

    ERIC Educational Resources Information Center

    Shasta-Tehama-Trinity Joint Community Coll. District, Redding, CA.

    This collective bargaining agreement between the Shasta-Tehama-Trinity Joint Community College District and the Shasta College Faculty Association establishes conditions of employment for all full- and part-time regular or contracted certificated employees of the district. The articles of the agreement set forth provisions related to: (1)…

  14. 75 FR 62424 - EDS, an HP Company (Re-Branded as HP-Enterprise Services) Including On-Site Workers From: Abel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... Floyd and Company, Trinity Government SYS a Private Co, Verizon Network Integration Corp, Vision... Provider Inc., Teksystems, The Experts Inc., TM Floyd and Company, Trinity Government SYS a Private Co... Compuware Corp Comsys Information Technology SVC, Diversified Systems Inc., E- Corn LLC, Farrington...

  15. 75 FR 28657 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    .../26/10 04/21/10. 73990 Trinity North American Fort Worth, TX........ 04/26/10 04/23/10. Freight Car.... (Workers). 73996 General Electric Company Owensboro, KY......... 04/27/10 04/23/10. (Company). 73997... Electric Control Morrison, IL 04/28/10 04/26/10. Products (Company). 74011 Kennametal, Inc. (Workers...

  16. Confirmatory Factor Analysis of the Trinity Inventory of Precursors to Suicide (TIPS) and Its Relationship to Hopelessness and Depression

    ERIC Educational Resources Information Center

    Smyth, Caroline L.; MacLachlan, Malcolm

    2005-01-01

    Numerous existing measures assess attitudes toward suicide yet fail to account for contextual factors. The Trinity Inventory of Precursors to Suicide (TIPS) is presented as an alternative, with implications for the development of prevention programs. Having previously reported exploratory analysis of the TIPS; confirmatory factor analysis and…

  17. 77 FR 69789 - Foreign-Trade Zone 171-Liberty County, TX; Application for Reorganization/Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ..., Cleveland; Site 2 (45 acres)-- Port of Liberty County Industrial Park located on Trinity River, Liberty; Site 3 (27 acres)--Port of Liberty County Industrial Park located on the Trinity River some 2 miles..., Highway FM 787, Liberty; Site 5 (583.081 acres)--Sjolander Plastics Storage Railyard facility, adjacent to...

  18. Access to NMR Spectroscopy for Two-Year College Students: The NMR Site at Trinity University

    ERIC Educational Resources Information Center

    Mills, Nancy S.; Shanklin, Michael

    2011-01-01

    Students at two-year colleges and small four-year colleges have often obtained their exposure to NMR spectroscopy through "canned" spectra because the cost of an NMR spectrometer, particularly a high-field spectrometer, is prohibitive in these environments. This article describes the design of a NMR site at Trinity University in which…

  19. 78 FR 51741 - Notice of Application for Withdrawal and Opportunity for Public Meeting; California

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... approximately 541 acres of National Forest System lands in the Shasta-Trinity National Forest for a period of 20..., Shasta-Trinity National Forest Headquarters, 530-226-2500 during regular business hours, 8 a.m. to 4:30 p... County, California. The above-described lands being National Forest System lands, the Secretary shall...

  20. Modeling water-quality loads to the reservoirs of the Upper Trinity River Basin, Texas, USA

    USDA-ARS?s Scientific Manuscript database

    Water quality modeling efforts have been conducted for 12 reservoirs in ten watersheds in Upper Trinity River Basin located in north Texas. The reservoirs are being used for water supply to the populated area around the Dallas-Fort Worth Metro and the water quality of some of these reservoirs has b...

  1. 1. INTERIOR VIEW WITH NAVE, BARREL VAULTED SOLEA, ICONOSTAS WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. INTERIOR VIEW WITH NAVE, BARREL VAULTED SOLEA, ICONOSTAS WITH ICON AND SANCTUARY. IN ARCH ABOVE THE SANCTUARY IS THE TABLE OF ABRAHAM. THE ICONOSTAS INCLUDES ICONS OF THE ARCHANGEL MICHAEL, THE HOLY TRINITY, MOTHER OF GOD HOLDING THE CHRIST CHILD, JESUS. - Holy Trinity-Holy Cross Greek Orthodox Church, 200 Nineteenth Street South, Birmingham, Jefferson County, AL

  2. Breaking the Bonds of Poverty: A Motivational Profile of Selected Welfare Single Mothers Entering College.

    ERIC Educational Resources Information Center

    Cheng, Barbara Davis

    Single mothers on welfare were recruited for a program at Trinity College of Vermont using a variety of methods: newspaper advertisements, admission office applicants, and welfare office solicitation. Eligible for the program were single mothers on welfare meeting all Trinity College entrance requirements and having an interest in and commitment…

  3. Establishing a Mathematics-Enrichment Community in a Multi-School Environment

    ERIC Educational Resources Information Center

    Thomson, Ian

    2005-01-01

    Trinity College is a low-fee independent school in Gawler, South Australia. The college has an enrolment of 3500 students of varied socioeconomic mix, drawn from the northern suburbs of Adelaide. Trinity has recently been restructured into four R-10 schools and one senior school for Years 11-13. The schools share a common mathematics curriculum.…

  4. Unholy Trinity? Secularism Institute Renews Liberal Arts Curriculum

    ERIC Educational Resources Information Center

    Keysar, Ariela

    2010-01-01

    Secularism is controversial in today's political debates, championed by some and vilified by others. So when Trinity College in Hartford, Conn., opened a center for the study of secularism in September 2005, some people worried that it could become a source of friction on campus--yet another battleground in the culture wars that are wreaking havoc…

  5. 76 FR 20302 - Listing Endangered and Threatened Species; 90-Day Finding on a Petition To List Chinook Salmon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... a Petition To List Chinook Salmon AGENCY: National Marine Fisheries Service (NMFS), National Oceanic... salmon (Oncorhynchus tshawytscha) in the Upper Klamath and Trinity Rivers Basin as threatened or... conduct a status review of the Chinook salmon in the Upper Klamath and Trinity Rivers Basin to determine...

  6. Vulnerability of ground water to contamination, northern Bexar County, Texas

    USGS Publications Warehouse

    Clark, Amy R.

    2003-01-01

    The Trinity aquifer, composed of Lower Cretaceous carbonate rocks, largely controls the ground-water hydrology in the study area of northern Bexar County, Texas. Discharge from the Trinity aquifer recharges the downgradient, hydraulically connected Edwards aquifer one of the most permeable and productive aquifers in the Nation and the sole source of water for more than a million people in south-central Texas. The unconfined, karstic outcrop of the Edwards aquifer makes it particularly vulnerable to contamination resulting from urbanization that is spreading rapidly northward across an "environmentally sensitive" recharge zone of the Edwards aquifer and its upgradient "catchment area," composed mostly of the less permeable Trinity aquifer.A better understanding of the Trinity aquifer is needed to evaluate water-management decisions affecting the quality of water in both the Trinity and Edwards aquifers. A study was made, therefore, in cooperation with the San Antonio Water System to assess northern Bexar County's vulnerability to ground-water contamination. The vulnerability of ground water to contamination in this area varies with the effects of five categories of natural features (hydrogeologic units, faults, caves and (or) sinkholes, slopes, and soils) that occur on the outcrop and in the shallow subcrop of the Glen Rose Limestone.Where faults affect the rates of recharge or discharge or the patterns of ground-water flow in the Glen Rose Limestone, they likewise affect the risk of water-quality degradation. Caves and sinkholes generally increase the vulnerability of ground water to contamination, especially where their occurrences are concentrated. The slope of land surface can affect the vulnerability of ground water by controlling where and how long a potential contaminant remains on the surface. Disregarding the exception of steep slopes which are assumed to have no soil cover the greater the slope, the less the risk of ground-water contamination. Because most soils in the study area are uniformly thin, they have only minimal effect on the vulnerability of ground water to contamination.The results of hydrogeologic mapping during the present study divide the outcrop of the Glen Rose Limestone into five mappable intervals, labeled (youngest to oldest) A through E. Of these intervals, only the middle (C) and the lowermost (E) generally provide appreciable permeability.The vulnerability assessment provided herein was determined by combining the presumed effects of selected natural features (with individual vulnerability ratings ranging from 0 through 35) using a grid-based, multilayer system of digital datasets and geographic information system analysis. The resulting vulnerability map comprises composite vulnerability ratings that range from 26 through 104. The relatively less vulnerable areas those containing no faults, sinkholes, or caves occupy about 92 percent of the study area. The most vulnerable areas are those containing both a fault and one or more caves. The distribution of the most vulnerable areas which trend from southwest to northeast, roughly parallel to the Balcones fault zone occur mainly where faults intersect caves.

  7. Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century.

    PubMed

    Gubler, Duane J

    2011-12-01

    Dengue is the most important arboviral disease of humans with over half of the world's population living in areas of risk. The frequency and magnitude of epidemic dengue have increased dramatically in the past 40 years as the viruses and the mosquito vectors have both expanded geographically in the tropical regions of the world. There are many factors that have contributed to this emergence of epidemic dengue, but only three have been the principal drivers: 1) urbanization, 2) globalization and 3) lack of effective mosquito control. The dengue viruses have fully adapted to a human-Aedes aegypti-human transmission cycle, in the large urban centers of the tropics, where crowded human populations live in intimate association with equally large mosquito populations. This setting provides the ideal home for maintenance of the viruses and the periodic generation of epidemic strains. These cities all have modern airports through which 10s of millions of passengers pass each year, providing the ideal mechanism for transportation of viruses to new cities, regions and continents where there is little or no effective mosquito control. The result is epidemic dengue. This paper discusses this unholy trinity of drivers, along with disease burden, prevention and control and prospects for the future.

  8. Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century

    PubMed Central

    Gubler, Duane J.

    2011-01-01

    Dengue is the most important arboviral disease of humans with over half of the world’s population living in areas of risk. The frequency and magnitude of epidemic dengue have increased dramatically in the past 40 years as the viruses and the mosquito vectors have both expanded geographically in the tropical regions of the world. There are many factors that have contributed to this emergence of epidemic dengue, but only three have been the principal drivers: 1) urbanization, 2) globalization and 3) lack of effective mosquito control. The dengue viruses have fully adapted to a human-Aedes aegypti-human transmission cycle, in the large urban centers of the tropics, where crowded human populations live in intimate association with equally large mosquito populations. This setting provides the ideal home for maintenance of the viruses and the periodic generation of epidemic strains. These cities all have modern airports through which 10s of millions of passengers pass each year, providing the ideal mechanism for transportation of viruses to new cities, regions and continents where there is little or no effective mosquito control. The result is epidemic dengue. This paper discusses this unholy trinity of drivers, along with disease burden, prevention and control and prospects for the future. PMID:22500131

  9. "A Victim of Its Own Success"? The Diploma in Addiction Studies at Trinity College Dublin

    ERIC Educational Resources Information Center

    Woods, Marguerite; Butler, Shane

    2011-01-01

    This article reviews and reflects on the Diploma in Addiction Studies: a 1-year, full-time programme taught at the School of Social Work and Social Policy in Trinity College Dublin since the academic year 1983/1984, which has recently had its external funding withdrawn. The programme was aimed at multidisciplinary classes, including students from…

  10. "The Problem of Trinity College Dublin": A Historical Perspective on Rationalisation in Higher Education in Ireland

    ERIC Educational Resources Information Center

    Walsh, John

    2014-01-01

    This paper offers a historical perspective on government policies for the rationalisation of higher education (HE) in Ireland through a critical re-appraisal of the initiative for "merger" of Trinity College and University College Dublin. The initiative launched by Donogh O'Malley in 1967 was the first significant attempt by an Irish…

  11. Seeing the Light: Visibility of the July '45 Trinity Atomic Bomb Test from the Inner Solar System

    ERIC Educational Resources Information Center

    Reed, B. Cameron

    2006-01-01

    In his "The Making of the Atomic Bomb," Richard Rhodes remarks of the July 16, 1945, Trinity atomic bomb test in New Mexico that "had astronomers been watching they could have seen it reflected from the moon, literal moonshine," an allusion to Ernest Rutherford's famous dismissal of the prospect of atomic energy. Investigating…

  12. Linking habitat quality with trophic performance of steelhead along forest gradients in the South Fork Trinity River watershed, California

    Treesearch

    Sarah G. McCarthy; Jeffrey J. Duda; John M. Emlen; Garth R. Hodgson; David A. Beauchamp

    2009-01-01

    We examined invertebrate prey, fish diet, and energy assimilation in relation to habitat variation for steelhead Oncorhynchus mykiss (anadromous rainbow trout) and rainbow trout in nine low-order tributaries of the South Fork Trinity River, northern California. These streams spanned a range of environmental conditions, which allowed us to use...

  13. LLNL Mercury Project Trinity Open Science Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dawson, Shawn A.

    The Mercury Monte Carlo particle transport code is used to simulate the transport of radiation through urban environments. These challenging calculations include complicated geometries and require significant computational resources to complete. In the proposed Trinity Open Science calculations, I will investigate computer science aspects of the code which are relevant to convergence of the simulation quantities with increasing Monte Carlo particle counts.

  14. Factors regulating early life history dispersal of Atlantic cod (Gadus morhua) from coastal Newfoundland.

    PubMed

    Stanley, Ryan R E; deYoung, Brad; Snelgrove, Paul V R; Gregory, Robert S

    2013-01-01

    To understand coastal dispersal dynamics of Atlantic cod (Gadus morhua), we examined spatiotemporal egg and larval abundance patterns in coastal Newfoundland. In recent decades, Smith Sound, Trinity Bay has supported the largest known overwintering spawning aggregation of Atlantic cod in the region. We estimated spawning and dispersal characteristics for the Smith Sound-Trinity Bay system by fitting ichthyoplankton abundance data to environmentally-driven, simplified box models. Results show protracted spawning, with sharply increased egg production in early July, and limited dispersal from the Sound. The model for the entire spawning season indicates egg export from Smith Sound is 13%•day(-1) with a net mortality of 27%•day(-1). Eggs and larvae are consistently found in western Trinity Bay with little advection from the system. These patterns mirror particle tracking models that suggest residence times of 10-20 days, and circulation models indicating local gyres in Trinity Bay that act in concert with upwelling dynamics to retain eggs and larvae. Our results are among the first quantitative dispersal estimates from Smith Sound, linking this spawning stock to the adjacent coastal waters. These results illustrate the biophysical interplay regulating dispersal and connectivity originating from inshore spawning of coastal northwest Atlantic.

  15. Recent Performance Results of VPIC on Trinity

    NASA Astrophysics Data System (ADS)

    Nystrom, W. D.; Bergen, B.; Bird, R. F.; Bowers, K. J.; Daughton, W. S.; Guo, F.; Le, A.; Li, H.; Nam, H.; Pang, X.; Stark, D. J.; Rust, W. N., III; Yin, L.; Albright, B. J.

    2017-10-01

    Trinity is a new DOE compute resource now in production at Los Alamos National Laboratory. Trinity has several new and unique features including two compute partitions, one with dual socket Intel Haswell Xeon compute nodes and one with Intel Knights Landing (KNL) Xeon Phi compute nodes, use of on package high bandwidth memory (HBM) for KNL nodes, ability to configure KNL nodes with respect to HBM model and on die network topology in a variety of operational modes at run time, and use of solid state storage via burst buffer technology to reduce time required to perform I/O. An effort is in progress to optimize VPIC on Trinity by taking advantage of these new architectural features. Results of work will be presented on performance of VPIC on Haswell and KNL partitions for single node runs and runs at scale. Results include use of burst buffers at scale to optimize I/O, comparison of strategies for using MPI and threads, performance benefits using HBM and effectiveness of using intrinsics for vectorization. Work performed under auspices of U.S. Dept. of Energy by Los Alamos National Security, LLC Los Alamos National Laboratory under contract DE-AC52-06NA25396 and supported by LANL LDRD program.

  16. Geologic and hydrostratigraphic map of the Anhalt, Fischer, and Spring Branch 7.5-minute quadrangles, Blanco, Comal, and Kendall Counties, Texas

    USGS Publications Warehouse

    Clark, Allan K.; Robert R. Morris,

    2015-01-01

    The hydrostratigraphic units of the Edwards and Trinity aquifers have been mapped and described herein using a classification system developed by Choquette and Pray (1970), which is based on porosity types being fabric or not-fabric selective. The naming of hydrostratigraphic units is also based on preexisting names and topographic or historical features that occur in outcrop. The only hydrostratigraphic unit of the Edwards aquifer present in the study area is VIII hydrostratigraphic unit. The mapped hydrostratigraphic units of the upper Trinity aquifer are, from top to bottom: the cavernous, Camp Bullis, upper evaporite, fossiliferous, and lower evaporite and they are interval equivalent to the upper member of the Glen Rose Limestone. The middle Trinity aquifer (interval equivalent to the lower member of the Glen Rose Limestone) contains, from top to bottom: the Bulverde, Little Blanco, Twin Sisters, Doeppenschmidt, Rust, and Honey Creek hydrostratigraphic units. The lower part of the middle Trinity aquifer is formed by the Hensell, Cow Creek, and Hammett hydrostratigraphic units which are interval equivalent to the Hensell Sand Member, the Cow Creek Limestone, and the Hammett Shale Member, respectively, of the Pearsall Formation.

  17. De novo transcript sequence reconstruction from RNA-Seq: reference generation and analysis with Trinity

    PubMed Central

    Yassour, Moran; Grabherr, Manfred; Blood, Philip D.; Bowden, Joshua; Couger, Matthew Brian; Eccles, David; Li, Bo; Lieber, Matthias; MacManes, Matthew D.; Ott, Michael; Orvis, Joshua; Pochet, Nathalie; Strozzi, Francesco; Weeks, Nathan; Westerman, Rick; William, Thomas; Dewey, Colin N.; Henschel, Robert; LeDuc, Richard D.; Friedman, Nir; Regev, Aviv

    2013-01-01

    De novo assembly of RNA-Seq data allows us to study transcriptomes without the need for a genome sequence, such as in non-model organisms of ecological and evolutionary importance, cancer samples, or the microbiome. In this protocol, we describe the use of the Trinity platform for de novo transcriptome assembly from RNA-Seq data in non-model organisms. We also present Trinity’s supported companion utilities for downstream applications, including RSEM for transcript abundance estimation, R/Bioconductor packages for identifying differentially expressed transcripts across samples, and approaches to identify protein coding genes. In an included tutorial we provide a workflow for genome-independent transcriptome analysis leveraging the Trinity platform. The software, documentation and demonstrations are freely available from http://trinityrnaseq.sf.net. PMID:23845962

  18. A conceptual model of the hydrogeologic framework, geochemistry, and groundwater-flow system of the Edwards-Trinity and related aquifers in the Pecos County region, Texas

    USGS Publications Warehouse

    Bumgarner, Johnathan R.; Stanton, Gregory P.; Teeple, Andrew; Thomas, Jonathan V.; Houston, Natalie A.; Payne, Jason; Musgrove, MaryLynn

    2012-01-01

    A conceptual model of the hydrogeologic framework, geochemistry, and groundwater-flow system of the Edwards-Trinity and related aquifers, which include the Pecos Valley, Igneous, Dockum, Rustler, and Capitan Reef aquifers, was developed as the second phase of a groundwater availability study in the Pecos County region in west Texas. The first phase of the study was to collect and compile groundwater, surface-water, water-quality, geophysical, and geologic data in the area. The third phase of the study involves a numerical groundwater-flow model of the Edwards-Trinity aquifer in order to simulate groundwater conditions based on various groundwater-withdrawal scenarios. Resource managers plan to use the results of the study to establish management strategies for the groundwater system. The hydrogeologic framework is composed of the hydrostratigraphy, structural features, and hydraulic properties of the groundwater system. Well and geophysical logs were interpreted to define the top and base surfaces of the Edwards-Trinity aquifer units. Elevations of the top and base of the Edwards-Trinity aquifer generally decrease from the southwestern part of the study area to the northeast. The thicknesses of the Edwards-Trinity aquifer units were calculated using the interpolated top and base surfaces of the hydrostratigraphic units. Some of the thinnest sections of the aquifer were in the eastern part of the study area and some of the thickest sections were in the Pecos, Monument Draw, and Belding-Coyanosa trough areas. Normal-fault zones, which formed as growth and collapse features as sediments were deposited along the margins of more resistant rocks and as overlying sediments collapsed into the voids created by the dissolution of Permian-age evaporite deposits, were delineated based on the interpretation of hydrostratigraphic cross sections. The lowest aquifer transmissivity values were measured in the eastern part of the study area; the highest transmissivity values were measured in a faulted area of the Monument Draw trough. Hydraulic conductivity values generally exhibited the same trends as the transmissivity values. Groundwater-quality data and groundwater-level data were used in context with the hydrogeologic framework to assess the chemical characteristics of water from different sources, regional groundwater-flow paths, recharge sources, the mixing of water from different sources, and discharge in the study area. Groundwater-level altitudes generally decrease from southwest to northeast and regional groundwater flow is from areas of recharge south and west to the north and northeast. Four principal sources of recharge to the Edwards-Trinity aquifer were identified: (1) regional flow that originated as recharge northwest of the study area, (2) runoff from the Barilla, Davis, and Glass Mountains, (3) return flow from irrigation, and (4) upwelling from deeper aquifers. Results indicated Edwards-Trinity aquifer water in the study area was dominated by mineralized, regional groundwater flow that most likely recharged during the cooler, wetter climates of the Pleistocene with variable contributions of recent, local recharge. Groundwater generally flows into the down-dip extent of the Edwards-Trinity aquifer where it discharges into overlying or underlying aquifer units, discharges from springs, discharges to the Pecos River, follows a regional flow path east out of the study area, or is withdrawn by groundwater wells. Structural features such as mountains, troughs, and faults play a substantial role in the distribution of recharge, local and regional groundwater flow, spring discharge, and aquifer interaction.

  19. Helicopter Electromagnetic and Magnetic Surveys of the Upper and Middle Zones of the Trinity Aquifer, Uvalde and Bexar Counties, Texas

    NASA Astrophysics Data System (ADS)

    Smith, D. V.; Blome, C. D.; Smith, B. D.; Clark, A. C.

    2009-12-01

    Detailed helicopter electromagnetic and magnetic surveys (HEM) were conducted in northern Uvalde and Bexar Counties, Texas, as part of a geologic mapping and hydrologic study being conducted by the U.S. Geological Survey (USGS). The aquifers of the Lower Cretaceous Trinity Group (collectively termed the Trinity aquifer) are an important regional water source in the Hill Country of south-central Texas. Rock units comprising the middle aquifer segment are represented by the lower member of the Glen Rose Formation and the Cow Creek Limestone and Hensel Sandstone members of the Pearsall Formation. The lower Trinity hydrologic segment is composed of the Hosston and Sligo Limestones and is confined by the overlying Hammet Shale. Karst features commonly occur in the Trinity Group because of the dissolution of gypsum- and anhydrite-rich beds. Faults and fractures have not been sufficiently analyzed to evaluate the effects these structures have on inter- and intra-formational groundwater flow. The survey in the north Seco Creek area covers the recharge zone of the Edwards aquifer and part of the catchment zone composed of the upper Trinity segment. These data augment the scant geologic mapping in the area by delineating faults, collapse features, and hydrostratigraphic units. The HEM survey in northern Bexar County covered the Camp Stanley Storage Activity, the Camp Bullis Training Site, parts of the recharge zone of the Edwards aquifer south of the military bases, and part of Cibolo Creek to the north. Basic line spacing was 200 meters using six frequencies. In-fill lines were flown with a spacing of 100 meters in the central part of the study area to better resolve geologic structures and karst features. The data processing took into account high EM interference and cultural noise. Apparent resistivity (ρa) maps are used in interpretation of geologic structures, trends, and in the identification of electrical properties of lithologic units. The ρa maps show the northwest trending faults of the Balcones fault zone as well as oblique trending cross faults. Though many of the major faults had been identified in previous geologic mapping, other possibly significant faults were not recognized from traditional techniques. High resistivities within the Glen Rose Limestone are indicative of more competent lithologies which have a greater limestone content. During the evolution of the groundwater system the limestone units are most likely to have developed secondary porosity conducive to establishing flow paths. In contrast, lower resistivities are associated with clay, marl, and mudstone units which have lower porosity and permeability. Resistivity depth sections along flight lines and 3D visualization of resistive zones define reefal structures in the middle Trinity segment. Detailed hydrogeologic mapping and HEM depth modeling illustrate the approach to be taken in future studies of the Trinity.

  20. Using Geophysics to Define Hydrostratigraphic Units in the Edwards and Trinity Aquifers, Texas

    NASA Astrophysics Data System (ADS)

    Smith, B. D.; Blome, C. D.; Clark, A. K.; Kress, W.; Smith, D. V.

    2007-05-01

    Airborne and ground geophysical surveys conducted in Uvalde, Medina, and northern Bexar counties, Texas, can be used to define and characterize hydrostratigraphic units of the Edwards and Trinity aquifers. Airborne magnetic surveys have defined numerous Cretaceous intrusive stocks and laccoliths, mainly in Uvalde County, that influence local hydrology and perhaps regional ground-water flow paths. Depositional environments in the aquifers can be classified as shallow water platforms (San Marcos Platform, Edwards Group), shoal and reef facies (Devils River Trend, Devils River Formation), and deeper water basins (Maverick Basin, West Nueces, McKnight, and Salmon Peak Formations). Detailed airborne and ground electromagnetic surveys have been conducted over the Edwards aquifer catchment zone (exposed Trinity aquifer rocks), recharge zone (exposed Edwards aquifer rocks), and artesian zone (confined Edwards) in the Seco Creek area (northeast Uvalde and Medina Counties; Devils River Trend). These geophysical survey data have been used to divide the Edwards exposed within the Balcones fault zone into upper and lower hydrostratigraphic units. Although both units are high electrical resistivity, the upper unit has slightly lower resistivity than the lower unit. The Georgetown Formation, at the top of the Edwards Group has a moderate resistivity. The formations that comprise the upper confining units to the Edwards aquifer rocks have varying resistivities. The Eagleford and Del Rio Groups (mainly clays) have very low resistivities and are excellent electrical marker beds in the Seco Creek area. The Buda Limestone is characterized by high resistivities. Moderate resistivities characterize the Austin Group rocks (mainly chalk). The older Trinity aquifer, underlying the Edwards aquifer rocks, is characterized by less limestone (electrically resistive or low conductivity units) and greater quantities of mudstones (electrically conductive or low resistivity units). In the western area (Devils River Trend and Maverick Basin) of the Trinity aquifer system there are well-defined collapse units and features that are marked by moderate resistivities bracketed by resistive limestone and conductive mudstone of the Glen Rose Limestone. In the central part of the aquifer (San Marcos Platform) the Trinity's lithologies are divided into upper and lower units with further subdivisions into hydrostratigraphic units. These hydrostratigraphic units are well mapped by an airborne electromagnetic survey in Bexar County. Electrical properties of the Edwards aquifer also vary across the fresh-saline water interface where ground and borehole electrical surveys have been conducted. The saline- saturated Edwards is predictably more conductive than the fresh-water saturated rocks. Similar fresh-saline water interfaces exist within the upper confining units of the Edwards aquifer (Carrizo-Wilcox aquifer) and the Trinity aquifer rocks.

  1. Water-quality assessment of the Trinity River Basin, Texas - Review and analysis of available pesticide information, 1968-91

    USGS Publications Warehouse

    Ulery, R.L.; Brown, M.F.

    1995-01-01

    Review of all available data showed that pesticides were detected to a substantial degree in various sample media over the time period covered by this report. The authors were able to locate little pesticide-sample data for ground water or for tributary streams because sampling efforts historically have been concentrated on the mainstem Trinity River.

  2. Extensional faulting in the southern Klamath Mountains, California

    USGS Publications Warehouse

    Schweickert, R.A.; Irwin, W.P.

    1989-01-01

    Large northeast striking normal faults in the southern Klamath Mountains may indicate that substantial crustal extension occurred during Tertiary time. Some of these faults form grabens in the Jurassic and older bedrock of the province. The grabens contain continental Oligocene or Miocene deposits (Weaverville Formation), and in two of them the Oligocene or Miocene is underlain by Lower Cretaceous marine formations (Great Valley sequence). At the La Grange gold placer mine the Oligocene or Miocene strata dip northwest into the gently southeast dipping mylonitic footwall surface of the La Grange fault. The large normal displacement required by the relations at the La Grange mine is also suggested by omission of several kilometers of structural thickness of bedrock units across the northeast continuation of the La Grange fault, as well as by significant changes in bedrock across some northeast striking faults elsewhere in the Central Metamorphic and Eastern Klamath belts. The Trinity ultramafic sheet crops out in the Eastern Klamath terrane as part of a broad northeast trending arch that may be structurally analogous to the domed lower plate of metamorphic core complexes found in eastern parts of the Cordillera. The northeast continuation of the La Grange fault bounds the southeastern side of the Trinity arch in the Eastern Klamath terrane and locally cuts out substantial lower parts of adjacent Paleozoic strata of the Redding section. Faults bounding the northwestem side of the Trinity arch generally trend northeast and juxtapose stacked thrust sheets of lower Paleozoic strata of the Yreka terrane against the Trinity ultramafic sheet. Geometric relations suggest that the Tertiary extension of the southern Klamath Mountains was in NW-SE directions and that the Redding section and the southern part of the Central Metamorphic terrane may be a large Tertiary allochthon detached from the Trinity ultramafic sheet. Paleomagnetic data indicate a lack of rotation about a vertical axis during the extension. We propose that the Trinity ultramafic sheet is structurally analogous to a metamorphic core complex; if so, it is the first core complex to be described that involves ultramafic rocks. We infer that Mesozoic terrane accretion produced a large gravitational instability in the crust that spread laterally during Tertiary extension

  3. Field comparison of OraQuick® ADVANCE Rapid HIV-1/2 antibody test and two blood-based rapid HIV antibody tests in Zambia

    PubMed Central

    2012-01-01

    Background Zambia’s national HIV testing algorithm specifies use of two rapid blood based antibody assays, Determine®HIV-1/2 (Inverness Medical) and if positive then Uni-GoldTM Recombigen HIV-1/2 (Trinity Biotech). Little is known about the performance of oral fluid based HIV testing in Zambia. The aims of this study are two-fold: 1) to compare the diagnostic accuracy (sensitivity and specificity) under field conditions of the OraQuick® ADVANCE® Rapid HIV-1/2 (OraSure Technologies, Inc.) to two blood-based rapid antibody tests currently in use in the Zambia National Algorithm, and 2) to perform a cost analysis of large-scale field testing employing the OraQuick®. Methods This was a operational retrospective research of HIV testing and questionnaire data collected in 2010 as part of the ZAMSTAR (Zambia South Africa TB and AIDS reduction) study. Randomly sampled individuals in twelve communities were tested consecutively with OraQuick® test using oral fluid versus two blood-based rapid HIV tests, Determine® and Uni-GoldTM. A cost analysis of four algorithms from health systems perspective were performed: 1) Determine® and if positive, then Uni-GoldTM (Determine®/Uni-GoldTM); based on current algorithm, 2) Determine® and if positive, then OraQuick® (Determine®/OraQuick®), 3) OraQuick® and if positive, then Determine® (OraQuick®/Determine®), 4) OraQuick® and if positive, then Uni-GoldTM (OraQuick®/Uni-GoldTM). This information was then used to construct a model using a hypothetical population of 5,000 persons with varying prevalence of HIV infection from 1–30%. Results 4,458 participants received both a Determine® and OraQuick® test. The sensitivity and specificity of the OraQuick® test were 98.7 (95%CI, 97.5–99.4) and 99.8 (95%CI, 99.6–99.9), respectively when compared to HIV positive serostatus. The average unit costs per algorithm were US$3.76, US$4.03, US$7.35, and US$7.67 for Determine®/Uni-GoldTM, Determine®/OraQuick®, OraQuick®/Determine®, and OraQuick®/Uni-GoldTM, respectively, for an HIV prevalence of 15%. Conclusions An alternative HIV testing algorithm could include OraQuick® test which had a high sensitivity and specificity. The current Determine®/Uni-GoldTM testing algorithm is the least expensive when compared to Determine®/OraQuick®, OraQuick®/Determine®, and OraQuick®/Uni-GoldTM in the Zambian setting. From our field experience, oral fluid based testing offers many advantages over blood-based testing, especially with self testing on the horizon. PMID:22871032

  4. Effect of ultrasonic tip and root-end filling material on bond strength.

    PubMed

    Vivan, Rodrigo Ricci; Guerreiro-Tanomaru, Juliane Maria; Bernardes, Ricardo Affonso; Reis, José Mauricio Santos Nunes; Hungaro Duarte, Marco Antonio; Tanomaru-Filho, Mário

    2016-11-01

    The objective of this study was to evaluate the bond strength of three root-end filling materials (MTAA-MTA Angelus, MTAS-experimental MTA Sealer, and ZOE- zinc oxide and eugenol cement) in retrograde preparations performed with different ultrasonic tips (CVD, Trinity, and Satelec). Ninety 2-mm root sections from single-rooted human teeth were used. The retrograde cavities were prepared by using the ultrasonic tips, coupled to a device for position standardization. The specimens were randomly divided into nine groups: CVD MTAA; CVD MTAS; CVD ZOE; Trinity MTAA; Trinity MTAS; Trinity ZOE; Satelec MTAA; Satelec MTAS; Satelec ZOE. Each resin disc/dentin/root-end filling material was placed in the machine to perform the push-out test. The specimens were examined in a stereomicroscope to evaluate the type of failure. Data were submitted to statistical analysis using ANOVA and Tukey tests (α = 0.05). The highest bond strength was observed for the CVD tip irrespective of the material used (P < 0.05). There was no significant difference for the Trinity TU-18 diamond and S12 Satelec tips (P > 0.05). MTAA and MTAS showed highest bond strength. The most common type of failure was adhesion between the filling material and dentin wall, except for ZOE, where mixed failure was predominant. The CVD tip favored higher bond strength of the root-end filling materials. MTA Angelus and experimental MTAS presented bond strength to dentin prepared with ultrasonic tips. Root-end preparation with the CVD tip positively influences the bond strength of root-end filling materials. MTA Angelus and experimental MTAS present bond strength to be used as root-end filling materials.

  5. Two-dimensional resistivity investigation along West Fork Trinity River, Naval Air Station-Joint Reserve Base, Carswell Field, Fort Worth, Texas, October 2004

    USGS Publications Warehouse

    Shah, Sachin D.; Stanton, Gregory P.

    2006-01-01

    Naval Air Station-Joint Reserve Base Carswell Field (NAS-JRB) at Fort Worth, Tex., constitutes a government-owned, contractor-operated facility that has been in operation since 1942. Contaminants, primarily volatile organic compounds and metals, have entered the ground-water-flow system through leakage from waste-disposal sites and manufacturing processes. Ground water flows from west to east toward the West Fork Trinity River. During October 2004, the U.S. Geological Survey conducted a two-dimensional (2D) resistivity investigation at a site along the West Fork Trinity River at the eastern boundary of NAS-JRB to characterize the distribution of subsurface resistivity. Five 2D resistivity profiles were collected, which ranged from 500 to 750 feet long and extended to a depth of 25 feet. The Goodland Limestone and the underlying Walnut Formation form a confining unit that underlies the alluvial aquifer. The top of this confining unit is the top of bedrock at NAS-JRB. The bedrock confining unit is the zone of interest because of the potential for contaminated ground water to enter the West Fork Trinity River through saturated bedrock. The study involved a capacitively-coupled resistivity survey and inverse modeling to obtain true or actual resistivity from apparent resistivity. The apparent resistivity was processed using an inverse modeling software program. The results of this program were used to generate distributions (images) of actual resistivity referred to as inverted sections or profiles. The images along the five profiles show a wide range of resistivity values. The two profiles nearest the West Fork Trinity River generally showed less resistivity than the three other profiles.

  6. Geomorphic mapping to support river restoration on the Trinity River downstream from Lewiston Dam, California, 1980-2011

    USGS Publications Warehouse

    Curtis, Jennifer A.; Guerrero, Timothy M.

    2015-01-01

    Historic land use, dam construction, water storage, and flow diversions in the Trinity River watershed have resulted in downstream geomorphic change, loss of salmonid habitat, and declines in salmonid populations. The USGS in cooperation with the Trinity River Restoration Program, a multi-agency partnership tasked with implementing federally mandated restoration, completed a geomorphic change assessment to inform the planning process for future restoration work. This report documents an ARCMAP geodatabase (v.10.0) containing geomorphic features digitized from a series of rectified orthophotographs (http://dx.doi.org/10.5066/F7TT4P04). Upland, riparian, and channel features were digitized from six available base images (1980, 1997, 2001, 2006, 2009, and 2011). This report describes the structure of the geodatabase and the methods used to delineate individual geomorphic features.

  7. LAMMPS Project Report for the Trinity KNL Open Science Period.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moore, Stan Gerald; Thompson, Aidan P.; Wood, Mitchell

    LAMMPS is a classical molecular dynamics code (lammps.sandia.gov) used to model materials science problems at Sandia National Laboratories and around the world. LAMMPS was one of three Sandia codes selected to participate in the Trinity KNL (TR2) Open Science period. During this period, three different problems of interest were investigated using LAMMPS. The first was benchmarking KNL performance using different force field models. The second was simulating void collapse in shocked HNS energetic material using an all-atom model. The third was simulating shock propagation through poly-crystalline RDX energetic material using a coarse-grain model, the results of which were used inmore » an ACM Gordon Bell Prize submission. This report describes the results of these simulations, lessons learned, and some hardware issues found on Trinity KNL as part of this work.« less

  8. Riparian Systems and Forest Management—Changes in Harvesting Techniques and their Effects on Decomposed Granitic Soils

    Treesearch

    John W. Bramhall

    1989-01-01

    In the 1950s, timber on steep granitic terrain in Trinity County, California was harvested by using the logging techniques of the time. After Trinity Dam was built in the 1960s, it became evident these techniques were not suited to quality riparian habitat and healthy anadromous fisheries. Since adoption of the Z'berg-Nejedly Forest Practice Act in 1973, efforts...

  9. Faunal assemblages and multi-scale habitat patterns in headwater tributaries of the South Fork Trinity River - an unregulated river embedded within a multiple-use landscape

    Treesearch

    H. H. Jr. Welsh; J. J. G. R. Hodgson; J. M. Emlen Duda

    2010-01-01

    Headwaters can represent 80% of stream kilometers in a watershed, and they also have unique physical and biological properties that have only recently been recognized for their importance in sustaining healthy functioning stream networks and their ecological services. We sampled 60 headwater tributaries in the South Fork Trinity River, a 2,430 km2...

  10. Factors Regulating Early Life History Dispersal of Atlantic Cod (Gadus morhua) from Coastal Newfoundland

    PubMed Central

    Stanley, Ryan R. E.; deYoung, Brad; Snelgrove, Paul V. R.; Gregory, Robert S.

    2013-01-01

    To understand coastal dispersal dynamics of Atlantic cod (Gadus morhua), we examined spatiotemporal egg and larval abundance patterns in coastal Newfoundland. In recent decades, Smith Sound, Trinity Bay has supported the largest known overwintering spawning aggregation of Atlantic cod in the region. We estimated spawning and dispersal characteristics for the Smith Sound-Trinity Bay system by fitting ichthyoplankton abundance data to environmentally-driven, simplified box models. Results show protracted spawning, with sharply increased egg production in early July, and limited dispersal from the Sound. The model for the entire spawning season indicates egg export from Smith Sound is 13%•day−1 with a net mortality of 27%•day–1. Eggs and larvae are consistently found in western Trinity Bay with little advection from the system. These patterns mirror particle tracking models that suggest residence times of 10–20 days, and circulation models indicating local gyres in Trinity Bay that act in concert with upwelling dynamics to retain eggs and larvae. Our results are among the first quantitative dispersal estimates from Smith Sound, linking this spawning stock to the adjacent coastal waters. These results illustrate the biophysical interplay regulating dispersal and connectivity originating from inshore spawning of coastal northwest Atlantic. PMID:24058707

  11. Lead isotopic composition of trinitite melt glass: evidence for the presence of Canadian industrial lead in the first atomic weapon test.

    PubMed

    Bellucci, Jeremy J; Simonetti, Antonio; Wallace, Christine; Koeman, Elizabeth C; Burns, Peter C

    2013-08-06

    The Pb isotopic compositions for 51 spots of melt glass in 11 samples of trinitite have been determined by laser ablation multicollector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS). Trinitite glass yields a large range of Pb isotopic compositions (i.e., (206)Pb/(204)Pb = 17.08-19.04), which reflect mixing between industrial Pb from materials used in the Trinity test and natural geologic components. Areas within trinitite melt glass containing high concentrations of both Cu and Pb, which are derived from the bomb and blast site-related components, were used for delineating the Pb isotopic composition corresponding to the anthropogenic Pb component. Comparison between the isotopic composition estimated here for the industrial Pb used in the Trinity test and those from known Pb deposits worldwide indicates close agreement with ore from the Buchans mine (Newfoundland, Canada). The Buchans mine was active during the time of the Trinity test and was operated by the American Smelting and Refining Company, which could have provided the Pb used in the test. The industrial Pb used in the Trinity test materials is not documented in the literature (or declassified) but could have been present in bricks, solder, pigs, or some other anthropogenic component related to the experiment.

  12. Astronomy and space sciences studies - use of a remotely controlled robotic observatory

    NASA Astrophysics Data System (ADS)

    Priskitch, Ray

    Trinity College in Perth, Western Australia, has designed a self-paced online astronomy and space science course in response to the Earth & Beyond strand of the State's Curriculum Framework learning environment. The course also provides senior physics students the opportunity to undertake research that contributes towards their school-based assessment. Special features of the course include use of the first remotely controlled robotic telescope in a secondary school within Australia, and direct real time links to NASA's Johnson Space Centre. The quantum leap in telescope design and control technology introduces users, especially school students, to a means of data collection and processing that hitherto was in the realm of the professional astronomer. No longer must students be, both in time and space, located at the telescope when an event is taking place. Convenience of use and the high quality of data allows students to undertake scientific investigations that were impractical or of dubious quality beforehand. The Astronomy and Space Sciences course at Trinity offers students the opportunity to explore the solar system and the universe beyond whilst also incorporating a wide range of subjects other than science per se such as mathematics, computing, geography, multimedia, religious education and art. Skills developed in this course are of practical value, such as image processing, and the context of the studies serve to illuminate and stimulate student awareness of our unique environment and its finiteness.

  13. Environmental Assessment of the Trinity River Discharge on Productivity in Trinity Bay.

    DTIC Science & Technology

    1972-09-15

    3 Metallic Ion Concentrations ...... .................. ... 33 Mercury ........... .......................... 36 Arsenic...TB 25 SE 8-10 27.0 -- 35 TB 26 SE 12 27.0 -- 25 TB 27 SE 10-12 30.0 -- 37 TB 28 SE 6-10 -- 28 18 TABLE I (continued) Eh* H2S Mg Ca Mg/Ca Mercury ...the Houston Ship Channel. Metallic ion Concentrations Concentrations of mercury , arsenic, calcium, and magnesium ions were determined for each bottom

  14. Trinity Bay Study: Dye tracing experiments

    NASA Technical Reports Server (NTRS)

    Ward, G. H., Jr.

    1972-01-01

    An analysis of the heat balance and temperature distribution within Trinity Bay near Galveston, Texas is presented. The effects of tidal currents, wind driven circulations, and large volume inflows are examined. Emphasis is placed on the effects of turbulent diffusion and local shears in currents. The technique of dye tracing to determine the parameters characterizing dispersion is described. Aerial photographs and maps are provided to show the flow conditions existing at different times and seasons.

  15. Seasonal Assessment of the Relationship between the Discharge of the Trinity River and the Trinity Bay Ecosystem.

    DTIC Science & Technology

    1973-08-25

    that the shad and anchovy 118 populations are primarily dependent on plankton for food, which means that the higher salinities necessary for increased...therefore, regulating salinity levels for shrimp would increase both the shrimp fishery and other fish populations dependent on shrimp, as well...Bay ecosystem is that the bay is dependent upon the river for nutrients Gnd for maintenance of the salinity gradient. Odum, ’ ;.. (1963), Copeland

  16. A conceptual hydrogeologic model for the hydrogeologic framework, geochemistry, and groundwater-flow system of the Edwards-Trinity and related aquifers in the Pecos County region, Texas

    USGS Publications Warehouse

    Thomas, Jonathan V.; Stanton, Gregory P.; Bumgarner, Johnathan R.; Pearson, Daniel K.; Teeple, Andrew; Houston, Natalie A.; Payne, Jason; Musgrove, MaryLynn

    2013-01-01

    Several previous studies have been done to compile or collect physical and chemical data, describe the hydrogeologic processes, and develop conceptual and numerical groundwater-flow models of the Edwards-Trinity aquifer in the Trans-Pecos region. Documented methods were used to compile and collect groundwater, surface-water, geochemical, geophysical, and geologic information that subsequently were used to develop this conceptual model.

  17. Barnett Shale or Strawn Group: Identifying the Source of Stray Gas through Noble Gases in the Trinity Aquifer, North-Central Texas

    NASA Astrophysics Data System (ADS)

    Wen, T.; Castro, M. C.; Nicot, J. P.; Hall, C. M.; Pinti, D. L.; Mickler, P. J.; Darvari, R.; Larson, T. E.

    2017-12-01

    The complete set of stable noble gases (He, Ne, Ar, Kr, Xe) is presented for Barnett Shale and Strawn Group production gas together with that of stray flowing gas present in the Trinity Aquifer, Texas. It places new constraints on the source of this stray gas and further shows that Barnett and Strawn gas have distinct crustal and atmospheric noble gas signatures, allowing clear identification of these two sources. Like Trinity Aquifer stray gas, Strawn gas is significantly more enriched in crustal 4He*, 21Ne*, and 40Ar* than Barnett gas. The similarity of Strawn and stray gas crustal noble gas signatures suggests that the Strawn is the source of stray gas in the Trinity Aquifer. Atmospheric 22Ne/36Ar ratios of stray gas mimic also that of Strawn, further reinforcing the notion that the source of stray gas in this aquifer is the Strawn. While noble gas signatures of Strawn and stray gas are consistent with a single-stage water degassing model, a two-stage oil modified groundwater exsolution fractionation model is required to explain the light atmospheric noble gas signature of Barnett Shale production gas. These distinct Strawn and Barnett noble gas signatures are likely the reflection of distinct evolution histories with Strawn gas being possibly older than that of Barnett Shale.

  18. Occurrence and Distribution of Organochlorine Compounds in Biological Tissue and Bed Sediment From Streams in the Trinity River Basin, Texas, 1992-93

    USGS Publications Warehouse

    Moring, J. Bruce

    1997-01-01

    This report describes the occurrence and distribution of organochlorine compounds in biological tissue and bed sediment from the Trinity River Basin study area of the National Water-Quality Assessment Program. Concentrations of organochlorine pesticides, polychlorinated biphenyls (PCBs), and other organochlorine compounds were determined in biological tissue and surficial bed sediment from 16 stream sites in the Trinity River Basin of east-central Texas. Asiatic clams (Corbicula fluminea) were collected at 10 sites, and fish, including blue catfish (Ictalurus furcatus), common carp (Cyprinus carpio), bluegill (Lepomis cyanellus), and yellow bullhead (Ameiurus natalis) were collected at all mainstem and two tributary sites. Thirty of the 36 compounds analyzed in biological tissue or surficial bed sediment were detected in one or both media. Overall, more organochlorine compounds were detected in bed sediment than in biological tissue; however, various chlordane isomers, DDT metabolites, and PCBs were detected more frequently in tissue than in sediment. The chlordane isomers and PCBs that were detected more frequently in biological tissue also were detected more frequently at urban sites than at agricultural sites. Organochlorine compound concentrations generally were highest in fish tissue from Trinity River mainstem sites. Fish tissue from the mainstem sites contained a higher percentage of lipids than did fish- and clam-tissue samples from the tributary sites.

  19. Hydrogen and oxygen isotope constraints on hydrothermal alteration of the Trinity peridotite, Klamath Mountains, California

    USGS Publications Warehouse

    Liakhovitch, V.; Quick, J.E.; Gregory, R.T.

    2005-01-01

    The Trinity peridotite represents a rare opportunity to examine a relatively fertile plagioclase peridotite that was exhumed and later subjected to intrusive events in a seafloor environment, followed by its emplacement and incorporation into a continent. Over 250 stable isotopic determinations on whole rocks and minerals elucidate the hydrothermal evolution of the Trinity complex. All three serpentine polymorphs are present in the Trinity peridotite; these separate on the basis of their ??D values: antigorite, -46 < ??D < -82??? and lizardite and chrysotile, -90 < ??D < -106 and -110 < ??D < -136???, respectively. Antigorite coexists with chlorite, talc, and tremolite in contact aureole assemblages associated with Silurian/Devonian gabbroic plutons. Lizardite and chrysotile alteration carries a meteoric signature, which suggests association with post-emplacement serpentinization, or overprinting of earlier low-temperature seafloor serpentinization. Regionally, contours of ??D values exhibit bull's-eye patterns associated with the gabbroic plutons, with ??D maxima coinciding with the blackwall alteration at the margins on the plutons. In contrast to the hydrogen isotope behavior, oxygen isotope values of the three polymorphs are indistinguishable, spanning the range 5.3 < ??18O< 7.5, and suggesting low integrated fluid fluxes and strongly 18O-shifted fluids. Inferred primary ?? 18O values for peridotite, gabbro, and late Mesozoic granodiorite indicate a progressive 18O enrichment with time for the source regions of the rocks. These isotopic signatures are consistent with the geology, petrochemistry, and geochronology of the Trinity massif, which indicate the following history: (1) lithospheric emplacement and cooling of the peridotite in an oceanic environment ??? 472 Ma; (2) intrusion of gabbroic plutons into cold peridotite in an arc environment between 435 and 404 Ma; and finally (3) intrusion of felsic plutons between 171 and 127 Ma, long after the peridotite was incorporated into the continental crust. Copyright ?? 2005 by V. H. Winston & Son, Inc. All rights reserved.

  20. Three-dimensional model of the hydrostratigraphy and structure of the area in and around the U.S. Army-Camp Stanley Storage Activity Area, northern Bexar County, Texas

    USGS Publications Warehouse

    Pantea, Michael P.; Blome, Charles D.; Clark, Allan K.

    2014-01-01

    A three-dimensional model of the Camp Stanley Storage Activity area defines and illustrates the surface and subsurface hydrostratigraphic architecture of the military base and adjacent areas to the south and west using EarthVision software. The Camp Stanley model contains 11 hydrostratigraphic units in descending order: 1 model layer representing the Edwards aquifer; 1 model layer representing the upper Trinity aquifer; 6 model layers representing the informal hydrostratigraphic units that make up the upper part of the middle Trinity aquifer; and 3 model layers representing each, the Bexar, Cow Creek, and the top of the Hammett of the lower part of the middle Trinity aquifer. The Camp Stanley three-dimensional model includes 14 fault structures that generally trend northeast/southwest. The top of Hammett hydrostratigraphic unit was used to propagate and validate all fault structures and to confirm most of the drill-hole data. Differences between modeled and previously mapped surface geology reflect interpretation of fault relations at depth, fault relations to hydrostratigraphic contacts, and surface digital elevation model simplification to fit the scale of the model. In addition, changes based on recently obtained drill-hole data and field reconnaissance done during the construction of the model. The three-dimensional modeling process revealed previously undetected horst and graben structures in the northeastern and southern parts of the study area. This is atypical, as most faults in the area are en echelon that step down southeasterly to the Gulf Coast. The graben structures may increase the potential for controlling or altering local groundwater flow.

  1. Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

    PubMed Central

    Stecher, David; Bronkers, Glenn; Noest, Jappe O.T.; Tulleken, Cornelis A.F.; Hoefer, Imo E.; van Herwerden, Lex A.; Pasterkamp, Gerard; Buijsrogge, Marc P.

    2014-01-01

    To simplify and facilitate beating heart (i.e., off-pump), minimally invasive coronary artery bypass surgery, a new coronary anastomotic connector, the Trinity Clip, is developed based on the excimer laser-assisted nonocclusive anastomosis technique. The Trinity Clip connector enables simplified, sutureless, and nonocclusive connection of the graft to the coronary artery, and an excimer laser catheter laser-punches the opening of the anastomosis. Consequently, owing to the complete nonocclusive anastomosis construction, coronary conditioning (i.e., occluding or shunting) is not necessary, in contrast to the conventional anastomotic technique, hence simplifying the off-pump bypass procedure. Prior to clinical application in coronary artery bypass grafting, the safety and quality of this novel connector will be evaluated in a long-term experimental porcine off-pump coronary artery bypass (OPCAB) study. In this paper, we describe how to evaluate the coronary anastomosis in the porcine OPCAB model using various techniques to assess its quality. Representative results are summarized and visually demonstrated. PMID:25490000

  2. Potential landscape and flux field theory for turbulence and nonequilibrium fluid systems

    NASA Astrophysics Data System (ADS)

    Wu, Wei; Zhang, Feng; Wang, Jin

    2018-02-01

    Turbulence is a paradigm for far-from-equilibrium systems without time reversal symmetry. To capture the nonequilibrium irreversible nature of turbulence and investigate its implications, we develop a potential landscape and flux field theory for turbulent flow and more general nonequilibrium fluid systems governed by stochastic Navier-Stokes equations. We find that equilibrium fluid systems with time reversibility are characterized by a detailed balance constraint that quantifies the detailed balance condition. In nonequilibrium fluid systems with nonequilibrium steady states, detailed balance breaking leads directly to a pair of interconnected consequences, namely, the non-Gaussian potential landscape and the irreversible probability flux, forming a 'nonequilibrium trinity'. The nonequilibrium trinity characterizes the nonequilibrium irreversible essence of fluid systems with intrinsic time irreversibility and is manifested in various aspects of these systems. The nonequilibrium stochastic dynamics of fluid systems including turbulence with detailed balance breaking is shown to be driven by both the non-Gaussian potential landscape gradient and the irreversible probability flux, together with the reversible convective force and the stochastic stirring force. We reveal an underlying connection of the energy flux essential for turbulence energy cascade to the irreversible probability flux and the non-Gaussian potential landscape generated by detailed balance breaking. Using the energy flux as a center of connection, we demonstrate that the four-fifths law in fully developed turbulence is a consequence and reflection of the nonequilibrium trinity. We also show how the nonequilibrium trinity can affect the scaling laws in turbulence.

  3. A model to predict the evolution of a gravel bed river under an imposed cyclic hydrograph and its application to the Trinity River

    NASA Astrophysics Data System (ADS)

    Viparelli, Enrica; Gaeuman, David; Wilcock, Peter; Parker, Gary

    2011-02-01

    Major changes in the morphology of the Trinity River in California, such as narrowing of the cross section and sedimentation of fine sediment in pools, occurred after the closure of a system of dams. These changes caused a dramatic reduction in the salmonid population and a resulting decline of the fishery. Gravel augmentation, regulated flood releases, and mechanical channel rehabilitation are currently being implemented to help restore the aquatic habitat of the river. The present paper describes a tool, named the Spawning Gravel Refresher, for designing and predicting the effects of gravel augmentation in gravel bed rivers. The tool assumes an imposed, cycled hydrograph. The model is calibrated and applied to the regulated reach of the Trinity River in four steps: (1) zeroing runs to reproduce conditions of mobile bed equilibrium as best can be estimated for the predam Trinity River, (2) runs to compare the predictions with the results of previous studies, (3) runs at an engineering time scale to reproduce the effects of the dams, and (4) runs to design gravel augmentation schemes. In the fourth group of runs, the combined effects of engineered flood flow releases and gravel augmentation are predicted. At an engineering time scale, the model indicates that the fraction of fine sediment in the surface layer and in the topmost part of the substrate should decrease when subjected to these two restoration measures, with a consequent improvement of the quality of the spawning gravel.

  4. Diversions from Red River to Lake Dallas, Texas; and related channel losses, February and March 1954

    USGS Publications Warehouse

    Holland, Pat H.

    1954-01-01

    During the period Feb. 10 to Mar. 3, 19541 the City of Dallas pumped 1,363 acre-feet of water from its Red River plant into Pecan Creek (a tributary of Elm Fork Trinity River) 3.5 miles above Gainesville; 1,272 acre-feet of this diversion reached the head of Lake Dallas. Discharge records were obtained at four points along the channels. This water was transported down the channels of Pecan Creek and Elm Fork Trinity River to Lake Dallas, a distance of about 31 miles.

  5. Variable glacier response to atmospheric warming, northern Antarctic Peninsula, 1988-2009

    NASA Astrophysics Data System (ADS)

    Davies, B. J.; Carrivick, J. L.; Glasser, N. F.; Hambrey, M. J.; Smellie, J. L.

    2012-09-01

    The northern Antarctic Peninsula has recently exhibited ice-shelf disintegration, glacier recession and acceleration. However, the dynamic response of land-terminating, ice-shelf tributary and tidewater glaciers has not yet been quantified or assessed for variability, and there are sparse data for glacier classification, morphology, area, length or altitude. This paper firstly classifies the area, length, altitude, slope, aspect, geomorphology, type and hypsometry of 194 glaciers on Trinity Peninsula, Vega Island and James Ross Island in 2009 AD. Secondly, this paper documents glacier change 1988-2009. In 2009, the glacierised area was 8140±262 km2. From 1988-2001, 90% of glaciers receded, and from 2001-2009, 79% receded. This equates to an area change of -4.4% for Trinity Peninsula eastern coast glaciers, -0.6% for western coast glaciers, and -35.0% for ice-shelf tributary glaciers from 1988-2001. Tidewater glaciers on the drier, cooler eastern Trinity Peninsula experienced fastest shrinkage from 1988-2001, with limited frontal change after 2001. Glaciers on the western Trinity Peninsula shrank less than those on the east. Land-terminating glaciers on James Ross Island shrank fastest in the period 1988-2001. This east-west difference is largely a result of orographic temperature and precipitation gradients across the Antarctic Peninsula, with warming temperatures affecting the precipitation-starved glaciers on the eastern coast more than on the western coast. Reduced shrinkage on the western Peninsula may be a result of higher snowfall, perhaps in conjunction with the fact that these glaciers are mostly grounded. Rates of area loss on the eastern side of Trinity Peninsula are slowing, which we attribute to the floating ice tongues receding into the fjords and reaching a new dynamic equilibrium. The rapid shrinkage of tidewater glaciers on James Ross Island is likely to continue because of their low elevations and flat profiles. In contrast, the higher and steeper tidewater glaciers on the eastern Antarctic Peninsula will attain more stable frontal positions after low-lying ablation areas are removed, reaching equilibrium more quickly.

  6. Effects of Thalassinoides ichnofabrics on the petrophysical properties of the Lower Cretaceous Lower Glen Rose Limestone, Middle Trinity Aquifer, Northern Bexar County, Texas

    NASA Astrophysics Data System (ADS)

    Golab, James A.; Smith, Jon J.; Clark, Allan K.; Blome, Charles D.

    2017-04-01

    The combined Edwards and Trinity aquifer system is the primary source of freshwater for the rapidly growing San Antonio and Austin metropolitan areas. The karstic Lower Cretaceous (Aptian-Albian) Lower Glen Rose Limestone (GRL) contains the middle Trinity aquifer and has been subdivided into six hydrostratigraphic units (HSUs) with distinct hydrologic characteristics. These HSUs were first identified in the subsurface via core examination at the Camp Stanley Storage Activity (CSSA) in northern Bexar County, Texas and were then correlated to associated gamma-ray and resistivity logs. The Trinity aquifer system is a telogenetic karst and fluid flow is directed primarily through solution-enhanced faults, fractures, and pervasive Thalassinoides networks because matrix porosity of both transmissive and confining HSUs is very low. Meteoric water infiltrates the Trinity aquifer through vertically-oriented faults and likely moves laterally through biogenic pores. Two 7.62 cm diameter GRL cores and well logs from monitoring wells CS-MW9-CC and CS-MW5-LGR recovered from the CSSA were used to characterize the effect such large-scale Thalassinoides networks have on the petrophysical properties (resistivity and natural gamma-ray) of four HSUs (Honey Creek, Rust, Doeppenschmidt, and Twin Sisters HSUs). Resistivity logs show that resistance values > 300 Ω-m correlate with well-developed biogenic porosity and values of 650 Ω-m are associated with solution enhancement of the Thalassinoides networks. These high resistivity zones are cyclical and are identified in muddy confining units, even when no changes in lithology or karstic development are identified. Pervasive Thalassinoides networks act as starting points for wide spread dissolution and lead to advanced karst development in transmissive HSUs. Natural gamma-ray logs do not reflect hydrologic characteristics directly, but are inversely correlated to resistivity logs and display m-scale cyclicity. Resistivity logs suggest that Thalassinoides networks are interconnected throughout strata within the GRL and when coupled with natural gamma-logs, the lateral distribution of these networks within HSUs can be correlated. Identifying such fluid pathways is of particular importance for wells not located in proximity to major faults and karstic features.

  7. ABC of ladder operators for rationally extended quantum harmonic oscillator systems

    NASA Astrophysics Data System (ADS)

    Cariñena, José F.; Plyushchay, Mikhail S.

    2017-07-01

    The problem of construction of ladder operators for rationally extended quantum harmonic oscillator (REQHO) systems of a general form is investigated in the light of existence of different schemes of the Darboux-Crum-Krein-Adler transformations by which such systems can be generated from the quantum harmonic oscillator. Any REQHO system is characterized by the number of separated states in its spectrum, the number of ‘valence bands’ in which the separated states are organized, and by the total number of the missing energy levels and their position. All these peculiarities of a REQHO system are shown to be detected and reflected by a trinity (A^+/- , B^+/- , C^+/-) of the basic (primary) lowering and raising ladder operators related between themselves by certain algebraic identities with coefficients polynomially-dependent on the Hamiltonian. We show that all the secondary, higher-order ladder operators are obtainable by a composition of the basic ladder operators of the trinity which form the set of the spectrum-generating operators. Each trinity, in turn, can be constructed from the intertwining operators of the two complementary minimal schemes of the Darboux-Crum-Krein-Adler transformations.

  8. Geodatabase and characteristics of springs within and surrounding the Trinity aquifer outcrops in northern Bexar County, Texas, 2010--11

    USGS Publications Warehouse

    Clark, Allan K.; Pedraza, Diana E.; Morris, Robert R.; Garcia, Travis J.

    2013-01-01

    The U.S. Geological Survey, in cooperation with the Trinity Glen Rose Groundwater Conservation District, the Edwards Aquifer Authority, and the San Antonio River Authority, developed a geodatabase of springs within and surrounding the Trinity aquifer outcrops in a 331-square-mile study area in northern Bexar County, Texas. The data used to develop the geodatabase were compiled from existing reports and databases, along with spring data collected between October 2010 and September 2011. Characteristics including the location, discharge, and water-quality properties were collected for known springs and documented in the geodatabase. A total of 141 springs were located within the study area, and 46 springs were field verified. The discharge at springs with flow ranged from 0.003 to 1.46 cubic feet per second. The specific conductance of the water discharging from the springs ranged from 167 to 1,130 microsiemens per centimeter at 25 degrees Celsius with a majority of values in the range of 500 microsiemens per centimeter at 25 degrees Celsius.

  9. Environmental and Cultural Impact Proposed Tennessee Colony Reservoir, Trinity River, Texas. Volume V. Appendix G.

    DTIC Science & Technology

    1972-01-01

    allocation. Pri- marily it is concerned with any land use that increases surface water runoff and soil compaction, two phenomena that decrease recharge... runoff . Forested filter strips between range and reser- voir boundary should be developed as a land use for water quality control and quail habitat. High...shown on Plates G-10 and G-11) some measures will also be necessary to prevent fertilizer pollution of the reservoir from excessive surface runoff . G

  10. Planning report for the Edwards-Trinity Regional Aquifer-System analysis in central Texas, southeast Oklahoma, and southwest Arkansas

    USGS Publications Warehouse

    Bush, Peter W.

    1986-01-01

    The Edwards-Trinity regional aquifer-system analysis project, begun in October 1985 and scheduled to be completed by October 1991, is one of a series of similar projects being conducted nationwide. The project is intended to define the hydrogeologic framework, and to describe the geochemistry and groundwater flow of the aquifer system in order to provide a better understanding of the system's long-term water-yielding potential. A multidisciplinary approach will be used in which computer-based digital simulation of flow in the system will be the principal method of hydrogeologic investigation.

  11. Evaluation of water resources in part of central Texas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baker, B.; Duffin, G.; Flores, R.

    1990-01-01

    Water resources in the Brazos, Red, Colorado, and Trinity River basins, in central Texas, were evaluated. In 1985 there was a little less than 81,000 acre-ft of groundwater pumped from all aquifers in the study area, with a little less than 77,000 acre-ft of groundwater pumped from the Trinity Group aquifer. Irrigation accounted for about 56% of all groundwater pumped. A serious problem associated with the development of groundwater from the Trinity Group aquifer is the decline of artesian pressure in areas of large groundwater withdrawals. Degradation of groundwater within the Antlers and Travis Peak Formations from oil-field brines andmore » organic material are problems in several counties. The deterioration of water qualify for the City of Blum has occurred over a 26-year period and is associated with water level declines in the Hensell Member of the Travis Peak Formation. The Woodbine Group yields good quality water at or near the outcrop; however, the residual sodium carbonate and percent sodium limits its use for irrigation, while high iron and fluoride content restricts its use for public supply. Existing surface reservoirs in the study area alone can supply 296,400 acre-ft of water under 2010 conditions. Nearly all of this water is either currently owned or under contract to supply current and future needs. An additional 176,000 acre-ft of surface water could become available with the development of the proposed Lake Bosque and Paluxy Reservoir projects and with reallocation of storage in existing Lakes Waco and Whitney. The amount of groundwater currently pumped exceeds the estimated annual effective recharge to the Trinity Group aquifer; the groundwater supply for the area will continue to be drawn from storage within the aquifer. 84 refs., 21 figs., 3 tabs.« less

  12. The Math You Need at Trinity College, Hartford CT

    NASA Astrophysics Data System (ADS)

    Geiss, C. E.

    2011-12-01

    Trinity College is a small, private, highly selective liberal arts college with approximately 2400 students. Most students have relatively well developed quantitative skills, but many are nevertheless insecure about their abilities and reluctant to engage in courses that stress quantitative content. I have used The Math You Need (TMYN) modules in an introductory geology course which serves both majors and non-majors in Trinity's Environmental Science Program. This dual audience makes the introduction of quantitative exercises labor intensive and challenging for both students and instructor. TMYN was introduced to a) offer the students an independent support structure outside of class and to b) free up some class and office hour time that would have been spent on mathematical background information. THMY was added to the course as a set of homework assignments preceding related laboratory exercises and homework assignments. During the semester most feedback regarding TMYN was negative. Some outspoken students either saw it as additional busywork or generally disliked "being taught by a computer". A review of pre- and post-test data, however, revealed that the exercises improved students' quantitative skills. Furthermore, in the assignments most students ranked the exercises as useful and rewarding. These positive results were relatively independent of student skill levels.

  13. Spatial data for Eurycea salamander habitats associated With three aquifers in south-central Texas

    USGS Publications Warehouse

    Heitmuller, Franklin T.; Reece, Brian D.

    2006-01-01

    Eurycea salamander taxa comprise 12 known species that inhabit springs and caves in south-central Texas. Many of these are threatened or endangered species, and some are found only at one location. A number of the neotenic salamanders might be at risk from habitat loss associated with declines in ground-water levels. Eurycea salamander habitats are associated with three aquifers in south-central Texas: (1) the Edwards-Trinity (Plateau) aquifer, (2) the Edwards (Balcones Fault Zone) aquifer, and (3) the Trinity aquifer. The Edwards (Balcones fault zone) aquifer is commonly separated into three segments: from southwest to northeast, the San Antonio segment, the Barton Springs segment, and the northern segment. The Trinity aquifer south of the Colorado River can be divided into three permeable zones, the upper, middle, and lower zone. The U.S. Geological Survey, in cooperation with the U.S. Fish and Wildlife Service, developed this report (geodatabase) to aggregate the spatial data necessary to assess the potential effects of ground-water declines on known Eurycea habitat locations in south-central Texas. The geodatabase provides information about spring habitats, spring flow, cave habitats, aquifers, and projected water levels.

  14. A new glacier inventory for 2009 reveals spatial and temporal variability in glacier response to atmospheric warming in the Northern Antarctic Peninsula, 1988-2009

    NASA Astrophysics Data System (ADS)

    Davies, B. J.; Carrivick, J. L.; Glasser, N. F.; Hambrey, M. J.; Smellie, J. L.

    2011-12-01

    The Northern Antarctic Peninsula has recently exhibited ice-shelf disintegration, glacier recession and acceleration. However, the dynamic response of land-terminating, ice-shelf tributary and tidewater glaciers has not yet been quantified or assessed for variability, and there are sparse published data for glacier classification, morphology, area, length or altitude. This paper firstly uses ASTER images from 2009 and a SPIRIT DEM from 2006 to classify the area, length, altitude, slope, aspect, geomorphology, type and hypsometry of 194 glaciers on Trinity Peninsula, Vega Island and James Ross Island. Secondly, this paper uses LANDSAT-4 and ASTER images from 1988 and 2001 and data from the Antarctic Digital Database (ADD) from 1997 to document glacier change 1988-2009. From 1988-2001, 90 % of glaciers receded, and from 2001-2009, 79 % receded. Glaciers on the western side of Trinity Peninsula retreated relatively little. On the eastern side of Trinity Peninsula, the rate of recession of ice-shelf tributary glaciers has slowed from 12.9 km2 a-1 (1988-2001) to 2.4 km2 a-1 (2001-2009). Tidewater glaciers on the drier, cooler Eastern Trinity Peninsula experienced fastest recession from 1988-2001, with limited frontal retreat after 2001. Land-terminating glaciers on James Ross Island also retreated fastest in the period 1988-2001. Large tidewater glaciers on James Ross Island are now declining in areal extent at rates of up to 0.04 km2 a-1. This east-west difference is largely a result of orographic temperature and precipitation gradients across the Antarctic Peninsula. Strong variability in tidewater glacier recession rates may result from the influence of glacier length, altitude, slope and hypsometry on glacier mass balance. High snowfall means that the glaciers on the Western Peninsula are not currently rapidly receding. Recession rates on the eastern side of Trinity Peninsula are slowing as the floating ice tongues retreat into the fjords and the glaciers reach a new dynamic equilibrium. The rapid glacier recession of tidewater glaciers on James Ross Island is likely to continue because of their low elevations and flat profiles. In contrast, the higher and steeper tidewater glaciers on the Eastern Antarctic Peninsula will attain more stable frontal positions after low-lying ablation areas are removed.

  15. Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.

    PubMed

    Yarasheski, Kevin E; Scherzer, Rebecca; Kotler, Donald P; Dobs, Adrian S; Tien, Phyllis C; Lewis, Cora E; Kronmal, Richard A; Heymsfield, Steven B; Bacchetti, Peter; Grunfeld, Carl

    2011-03-01

    Skeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls. Whole-body (1)H-magnetic resonance imaging was used to quantify regional and total SM in 399 HIV-infected and 204 control men and women at baseline and 5 years later. Multivariable regression identified associated factors. At baseline and Year 5, total SM was lower in HIV-infected than control men. HIV-infected women were similar to control women at both time points. After adjusting for demographics, lifestyle factors, and total adipose tissue, HIV infection was associated with lower Year 5 SM in men and higher SM in women compared with controls. Average overall 5-year change in total SM was small and age related, but rate of change was similar in HIV-infected and control men and women. CD4 count and efavirenz use in HIV-infected participants were associated with increasing SM, whereas age and stavudine use were associated with decreasing SM. Muscle mass was lower in HIV-infected men compared with controls, whereas HIV-infected women had slightly higher SM than control women after multivariable adjustment. We found evidence against substantially faster SM decline in HIV infected versus similar-aged controls. SM gain was associated with increasing CD4 count, whereas stavudine use may contribute to SM loss.

  16. Comorbidity is more common and occurs earlier in persons living with HIV than in HIV-uninfected matched controls, aged 50 years and older: A cross-sectional study.

    PubMed

    Maciel, Rafael Aguiar; Klück, Helena Moreira; Durand, Madeleine; Sprinz, Eduardo

    2018-05-01

    At present, data are limited on the comorbidity profiles associated with aging people with HIV in the developing world, where most such people live. The aim of this study was to compare the disease burden between older HIV-positive subjects and HIV-negative matched controls in Brazil. This was a cross-sectional analysis of the South Brazilian HIV Cohort. Individuals aged 50 years and older were enrolled at Hospital de Clínicas de Porto Alegre and matched with HIV-negative controls from the primary practice unit of the same hospital. Multimorbidity (the presence of two or more comorbid conditions) and the number of non-infectious comorbidities were compared. Poisson regression was used to identify factors associated with multimorbidity. A total of 208 HIV-positive subjects were matched to 208 HIV-negative controls. Overall, the median age was 57 years and 56% were male. The prevalence of multimorbidity was higher in HIV-positive subjects than in HIV-negative controls (63% vs. 43%, p<0.001), and the median number of comorbidities was 2, compared to 1 in controls (p<0.001). The duration of HIV infection (p=0.02) and time on treatment in years (p=0.015) were associated with greater multimorbidity in HIV-positive persons. In this large cohort from the developing world, multimorbidity was found to be more common in HIV-positive subjects than in HIV-negative controls. The duration of HIV and time on antiretrovirals were associated with multimorbidity. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  17. Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study.

    PubMed

    Downs, Jennifer A; Dupnik, Kathryn M; van Dam, Govert J; Urassa, Mark; Lutonja, Peter; Kornelis, Dieuwke; de Dood, Claudia J; Hoekstra, Pytsje; Kanjala, Chifundo; Isingo, Raphael; Peck, Robert N; Lee, Myung Hee; Corstjens, Paul L A M; Todd, Jim; Changalucha, John M; Johnson, Warren D; Fitzgerald, Daniel W

    2017-09-01

    Schistosomiasis affects 218 million people worldwide, with most infections in Africa. Prevalence studies suggest that people with chronic schistosomiasis may have higher risk of HIV-1 acquisition and impaired ability to control HIV-1 replication once infected. We hypothesized that: (1) pre-existing schistosome infection may increase the odds of HIV-1 acquisition and that the effects may differ between men and women, and (2) individuals with active schistosome infection at the time of HIV-1 acquisition may have impaired immune control of HIV-1, resulting in higher HIV-1 viral loads at HIV-1 seroconversion. We conducted a nested case-control study within a large population-based survey of HIV-1 transmission in Tanzania. A population of adults from seven villages was tested for HIV in 2007, 2010, and 2013 and dried blood spots were archived for future studies with participants' consent. Approximately 40% of this population has Schistosoma mansoni infection, and 2% has S. haematobium. We tested for schistosome antigens in the pre- and post-HIV-1-seroconversion blood spots of people who acquired HIV-1. We also tested blood spots of matched controls who did not acquire HIV-1 and calculated the odds that a person with schistosomiasis would become HIV-1-infected compared to these matched controls. Analysis was stratified by gender. We compared 73 HIV-1 seroconverters with 265 controls. Women with schistosome infections had a higher odds of HIV-1 acquisition than those without (adjusted OR = 2.8 [1.2-6.6], p = 0.019). Schistosome-infected men did not have an increased odds of HIV-1 acquisition (adjusted OR = 0.7 [0.3-1.8], p = 0.42). We additionally compared HIV-1 RNA levels in the post-seroconversion blood spots in HIV-1 seroconverters with schistosomiasis versus those without who became HIV-infected in 2010, before antiretroviral therapy was widely available in the region. The median whole blood HIV-1 RNA level in the 15 HIV-1 seroconverters with schistosome infection was significantly higher than in the 22 without schistosomiasis: 4.4 [3.9-4.6] log10 copies/mL versus 3.7 [3.2-4.3], p = 0.017. We confirm, in an area with endemic S. mansoni, that pre-existing schistosome infection increases odds of HIV-1 acquisition in women and raises HIV-1 viral load at the time of HIV-1 seroconversion. This is the first study to demonstrate the effect of schistosome infection on HIV-1 susceptibility and viral control, and to differentiate effects by gender. Validation studies will be needed at additional sites.

  18. Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects.

    PubMed

    Scherzer, Rebecca; Shen, Wei; Bacchetti, Peter; Kotler, Donald; Lewis, Cora E; Shlipak, Michael G; Punyanitya, Mark; Heymsfield, Steven B; Grunfeld, Carl

    2008-10-01

    Studies in persons without HIV infection have compared adipose tissue measured by dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI), but no such study has been conducted in HIV-infected (HIV+) subjects, who have a high prevalence of regional fat loss. We compared DXA- with MRI-measured trunk, leg, arm, and total fat in HIV+ and control subjects. A cross-sectional analysis was conducted in 877 HIV+ subjects and 260 control subjects in FRAM (Study of Fat Redistribution and Metabolic Change in HIV Infection), stratified by sex and HIV status. Univariate associations of DXA with MRI were strongest for total and trunk fat (r > or = 0.92) and slightly weaker for leg (r > or = 0.87) and arm (r > or = 0.71) fat. The average estimated limb fat was substantially greater for DXA than for MRI for HIV+ and control men and women (all P < 0.0001). Less of a difference was observed in trunk fat measured by DXA and MRI, but the difference was still statistically significant (P < 0.0001). Bland-Altman plots showed increasing differences and variability. Greater average limb fat in control and HIV+ subjects (both P < 0.0001) was associated with greater differences between DXA and MRI measurements. Because the control subjects had more limb fat than did the HIV+ subjects, greater amounts of fat were measured by DXA than by MRI when control subjects were compared with HIV+ subjects. More HIV+ subjects had leg fat in the bottom decile of the control subjects by DXA than by MRI (P < 0.0001). Although DXA- and MRI-measured adipose tissue depots correlate strongly in HIV+ and control subjects, differences increase as average fat increases, particularly for limb fat. DXA may estimate a higher prevalence of peripheral lipoatrophy than does MRI in HIV+ subjects.

  19. Age-Related Skeletal Muscle Decline Is Similar in HIV-Infected and Uninfected Individuals

    PubMed Central

    Yarasheski, Kevin E.; Scherzer, Rebecca; Kotler, Donald P.; Dobs, Adrian S.; Tien, Phyllis C.; Lewis, Cora E.; Kronmal, Richard A.; Heymsfield, Steven B.; Bacchetti, Peter

    2011-01-01

    Background. Skeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls. Methods. Whole-body 1H-magnetic resonance imaging was used to quantify regional and total SM in 399 HIV-infected and 204 control men and women at baseline and 5 years later. Multivariable regression identified associated factors. Results. At baseline and Year 5, total SM was lower in HIV-infected than control men. HIV-infected women were similar to control women at both time points. After adjusting for demographics, lifestyle factors, and total adipose tissue, HIV infection was associated with lower Year 5 SM in men and higher SM in women compared with controls. Average overall 5-year change in total SM was small and age related, but rate of change was similar in HIV-infected and control men and women. CD4 count and efavirenz use in HIV-infected participants were associated with increasing SM, whereas age and stavudine use were associated with decreasing SM. Conclusions. Muscle mass was lower in HIV-infected men compared with controls, whereas HIV-infected women had slightly higher SM than control women after multivariable adjustment. We found evidence against substantially faster SM decline in HIV infected versus similar-aged controls. SM gain was associated with increasing CD4 count, whereas stavudine use may contribute to SM loss. PMID:21310810

  20. Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia

    PubMed Central

    Johnson, Susan; Eller, Michael; Teigler, Jeffrey E.; Maloveste, Sebastien M.; Schultz, Bruce T.; Soghoian, Damien Z.; Lu, Richard; Oster, Alexander F.; Chenine, Agnès-Laurence; Alter, Galit; Dittmer, Ulf; Marovich, Mary; Robb, Merlin L.; Michael, Nelson L.; Bolton, Diane

    2015-01-01

    ABSTRACT CD4+ T cells play a pivotal role in the control of chronic viral infections. Recently, nontraditional CD4+ T cell functions beyond helper effects have been described, and a role for cytolytic CD4+ T cells in the control of HIV infection has been suggested. We define here the transcriptional, phenotypic, and functional profiles of HIV-specific cytolytic CD4+ T cells. Fluidigm BioMark and multiparameter flow cytometric analysis of HIV-specific cytolytic CD4+ T cells revealed a distinct transcriptional signature compared to Th1 CD4+ cells but shared similar features with HIV-specific cytolytic CD8+ T cells. Furthermore, HIV-specific cytolytic CD4+ T cells showed comparable killing activity relative to HIV-specific CD8+ T cells and worked cooperatively in the elimination of virally infected cells. Interestingly, we found that cytolytic CD4+ T cells emerge early during acute HIV infection and tightly follow acute viral load trajectory. This emergence was associated to the early viral set point, suggesting an involvement in early control, in spite of CD4 T cell susceptibility to HIV infection. Our data suggest cytolytic CD4+ T cells as an independent subset distinct from Th1 cells that show combined activity with CD8+ T cells in the long-term control of HIV infection. IMPORTANCE The ability of the immune system to control chronic HIV infection is of critical interest to both vaccine design and therapeutic approaches. Much research has focused on the effect of the ability of CD8+ T cells to control the virus, while CD4+ T cells have been overlooked as effectors in HIV control due to the fact that they are preferentially infected. We show here that a subset of HIV-specific CD4+ T cells cooperate in the cytolytic control of HIV replication. Moreover, these cells represent a distinct subset of CD4+ T cells showing significant transcriptional and phenotypic differences compared to HIV-specific Th1 cells but with similarities to CD8+ T cells. These findings are important for our understanding of HIV immunopathology. PMID:25972560

  1. The Perils of Paul: Near Disasters in Airborne Radiochemical Sampling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meade, Roger Allen

    Beginning with the Trinity test in July 1945, Laboratory radiochemists have collected debris from nuclear tests by various means. At Trinity, two United States Army Sherman tanks were used. Beginning with Operation Crossroads and continuing throughout atmospheric testing, aircraft were used to fly in and around mushroom clouds to collect debris. Paul Guthals, the LASL project leader for sampling operations, flew on many of the B-57 sampling missions. Two such missions, one flown over the Nevada Test and one in the skies near Johnston Atoll, again proved the dangers involved in collecting airborne test debris. The events of these twomore » missions are briefly recounted.« less

  2. Psychiatric morbidity in asymptomatic human immunodeficiency virus patients.

    PubMed

    Chauhan, V S; Chaudhury, Suprakash; Sudarsanan, S; Srivastava, Kalpana

    2013-07-01

    Psychiatric morbidity in human immunodeficiency virus (HIV) patients is being studied all over the world. There is paucity of Indian literature particularly in asymptomatic HIV individuals. The aim of the following study is to establish the prevalence and the determinants of psychiatric morbidity in asymptomatic HIV patients. A cross-sectional study was undertaken to assess psychiatric morbidity as per ICD-10 dacryocystorhinostomy criteria in 100 consecutive asymptomatic seropositive HIV patients and an equal number of age, sex, education, economic and marital status matched HIV seronegative control. All subjects were assessed with the general health questionnaire (GHQ), mini mental status examination, hospital anxiety and depression scale (HADS) and sensation seeking scale (SSS) and the scores were analyzed statistically. Asymptomatic HIV positive patients had significantly higher GHQ caseness and depression but not anxiety on HADS as compared to HIV seronegative controls. On SSS asymptomatic HIV seropositive subjects showed significant higher scores in thrill and adventure seeking, experience seeking and boredom susceptibility as compared to controls. HIV seropositive patients had significantly higher incidence of total psychiatric morbidity. Among the individual disorders, alcohol dependence syndrome, sexual dysfunction and adjustment disorder were significantly increased compared with HIV seronegative controls. Psychiatric morbidity is higher in asymptomatic HIV patients when compared to HIV seronegative controls. Among the individual disorders, alcohol dependence syndrome, sexual dysfunction and adjustment disorder were significantly increased compared with HIV seronegative controls. High sensation seeking and substance abuse found in HIV seropositive patients may play a vital role in engaging in high-risk behavior resulting in this dreaded illness.

  3. The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

    PubMed Central

    Friis, Anna M. C.; Gyllensten, Katarina; Aleman, Anna; Ernberg, Ingemar; Åkerlund, Börje

    2010-01-01

    We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV. PMID:21994658

  4. Plasma cytokine levels and risk of HIV type 1 (HIV-1) transmission and acquisition: a nested case-control study among HIV-1-serodiscordant couples.

    PubMed

    Kahle, Erin M; Bolton, Michael; Hughes, James P; Donnell, Deborah; Celum, Connie; Lingappa, Jairam R; Ronald, Allan; Cohen, Craig R; de Bruyn, Guy; Fong, Youyi; Katabira, Elly; McElrath, M Juliana; Baeten, Jared M

    2015-05-01

    A heightened proinflammatory state has been hypothesized to enhance human immunodeficiency virus type 1 (HIV-1) transmission - both susceptibility of HIV-1-exposed persons and infectiousness of HIV-1-infected persons. Using prospective data from heterosexual African couples with HIV-1 serodiscordance, we conducted a nested case-control analysis to assess the relationship between cytokine concentrations and the risk of HIV-1 acquisition. Case couples (n = 120) were initially serodiscordant couples in which HIV-1 was transmitted to the seronegative partner during the study; control couples (n = 321) were serodiscordant couples in which HIV-1 was not transmitted to the seronegative partner. Differences in a panel of 30 cytokines were measured using plasma specimens from both HIV-1-susceptible and HIV-1-infected partners. Plasma was collected before seroconversion for cases. For both HIV-1-infected and HIV-1-susceptible partners, cases and controls had significantly different mean responses in cytokine panels (P < .001, by the Hotelling T(2) test), suggesting a broadly different pattern of immune activation for couples in which HIV-1 was transmitted, compared with couples without transmission. Individually, log10 mean concentrations of interleukin 10 (IL-10) and CXCL10 were significantly higher for both HIV-1-susceptible and HIV-1-infected case partners, compared with HIV-1-susceptible and HIV-1-infected control partners (P < .01 for all comparisons). In multivariate analysis, HIV-1 transmission was significantly associated with elevated CXCL10 concentrations in HIV-1-susceptible partners (P = .001) and with elevated IL-10 concentrations in HIV-1-infected partners (P = .02). Immune activation, as measured by levels of cytokine markers, particularly elevated levels of IL-10 and CXCL1, are associated with increased HIV-1 susceptibility and infectiousness. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Organic compounds in Elm Fork Trinity River water used for public supply near Carrollton, Texas, 2002-05

    USGS Publications Warehouse

    Ging, Patricia B.; Delzer, Gregory C.; Hamilton, Pixie A.

    2009-01-01

    Organic compounds studied in this U.S. Geological Survey (USGS) assessment generally are man-made, including pesticides, solvents, gasoline hydrocarbons, personal-care and domestic-use products, refrigerants, and propellants. A total of 103 of 277 compounds were detected at least once among the 30 samples of source water for a community water system on the Elm Fork Trinity River near Carrollton, Texas, collected approximately monthly during 2002-05. The diversity of compounds detected indicates a variety of different sources and uses (including wastewater discharge, industrial, agricultural, domestic, and others) and different pathways (including overland runoff and groundwater discharge) to drinking-water supplies. Nine compounds were detected year-round in source-water samples, including chloroform, methyl tert-butyl ether (MTBE), and selected herbicide compounds commonly used in the Trinity River Basin and in other urban areas across the United States. About 90 percent of the 42 compounds detected most frequently in source water (in at least 20 percent of the samples) also were detected most frequently in finished water (after treatment but before distribution). Concentrations for all detected compounds in source and finished water generally were less than 0.1 microgram per liter and always less than human-health benchmarks, which are available for about one-half of the detected compounds.

  6. In search of the Abrams post office, Trinity County

    USGS Publications Warehouse

    Lanphere, Marvin A.; Irwin, William P.

    1987-01-01

    An understanding of earth history depends in part on stratigraphy, a division of geology in which the distinctive features of natural units or formations of layered rocks are studied and described and names are assigned to them. The procedures for describing and naming rock units in a uniform way are incorporated in documents known as stratigraphic codes. The North American Stratigraphic Code (1983) is currently used by most geologists in the United States when formation names are selected. Rock unit names consist of a geographic name, generally taken from a natural feature near the locality where the unit was first described, followed by a descriptive feature, usually the dominant rock type in the unit. Although the procedure for naming a rock unit seems straightforward, stratigraphic nomenclature can lead to confusion when the principles outlined in the stratigraphic code are ignored or incorrectly applied. This paper traces the naming of the Abrams Mica Schist, one of the major units of the northern California Klamath Mountains. It describes how uncertainty about the location of the geographic feature after which the unit was named has led to conflicting terminology. The search revealed some interesting history of the early days of mining in the Coffee Creek region of the Trinity Alps in Trinity County. 

  7. Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.

    PubMed

    Hersperger, Adam R; Migueles, Stephen A; Betts, Michael R; Connors, Mark

    2011-05-01

    Over the past 2 years, a clearer picture has emerged regarding the properties of HIV-specific CD8+ T cells associated with immunologic control of HIV replication. These properties represent a potential mechanism by which rare patients might control HIV replication in the absence of antiretroviral therapy. This review addresses the background and recent findings that have lead to our current understanding of these mechanism(s). Patients with immunologic control of HIV are not distinguished by targeted specificities, or greater numbers or breadth of their HIV-specific CD8+ T-cell response. For this reason, recent work has focused greater attention on qualitative features of this response. The qualitative features most closely associated with immunologic control of HIV are related to the granule-exocytosis-mediated elimination of HIV-infected CD4 T cells. The ability of HIV-specific CD8+ T cells to increase their contents of proteins known to mediate cytotoxicity, such as granzyme B and perforin, appears to be a critical means by which HIV-specific cytotoxic capacity is regulated. Investigation from multiple groups has now focused upon HIV-specific CD8+ T-cell granule-exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near future, a more detailed understanding of the qualities associated with immunologic control may provide critical insights regarding the necessary features of a response that should be stimulated by immunotherapies or T-cell-based vaccines.

  8. Advancing Biosocial Pedagogy for HIV Education

    ERIC Educational Resources Information Center

    Davis, Mark David McGregor

    2011-01-01

    This article develops the concept of biosocial pedagogy in HIV education for this era of expanding biomedical forms of HIV control. With reference to critical pedagogy and teaching and learning materials addressing HIV treatment and prevention, I explain how HIV education can problematize its own role in HIV control. I also discuss how educational…

  9. New Insights Into Valley Formation and Preservation: Geophysical Imaging of the Offshore Trinity River Paleovalley

    NASA Astrophysics Data System (ADS)

    Speed, C. M.; Swartz, J. M.; Gulick, S. P. S.; Goff, J.

    2017-12-01

    The Trinity River paleovalley is an offshore stratigraphic structure located on the inner continental shelf of the Gulf of Mexico offshore Galveston, Texas. Its formation is linked to the paleo-Trinity system as it existed across the continental shelf during the last glacial period. Newly acquired high-resolution geophysical data have imaged more complexity to the valley morphology and shelf stratigraphy than was previously captured. Significantly, the paleo-Trinity River valley appears to change in the degree of confinement and relief relative to the surrounding strata. Proximal to the modern shoreline, the interpreted time-transgressive erosive surface formed by the paleo-river system is broad and rugose with no single valley, but just 5 km farther offshore the system appears to become confined to a 10 km wide valley structure before again becoming unconfined once again 30 km offshore. Fluvial stratigraphy in this region has a similar degree of complexity in morphology and preservation. A dense geophysical survey of several hundred km is planned for Fall 2017, which will provide unprecedented imaging of the paleovalley morphology and associated stratigraphy. Our analysis leverages robust chirp processing techniques that allow for imaging of strata on the decimeter scale. We will integrate our geophysical results with a wide array of both newly collected and previously published sediment cores. This approach will allow us to address several key questions regarding incised valley formation and preservation on glacial-interglacial timescales including: to what extent do paleo-rivers remain confined within a single broad valley structure, what is the fluvial systems response to transgression, and what stratigraphy is created and preserved at the transition from fluvial to estuarine environments? Our work illustrates that traditional models of incised valley formation and subsequent infilling potentially fail to capture the full breadth of dynamics of past river systems.

  10. Evaluation of the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) in a malaria endemic area in Ghana, Africa.

    PubMed

    Adu-Gyasi, Dennis; Asante, Kwaku Poku; Newton, Sam; Dosoo, David; Amoako, Sabastina; Adjei, George; Amoako, Nicholas; Ankrah, Love; Tchum, Samuel Kofi; Mahama, Emmanuel; Agyemang, Veronica; Kayan, Kingsley; Owusu-Agyei, Seth

    2015-01-01

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most widespread enzyme defect that can result in red cell breakdown under oxidative stress when exposed to certain medicines including antimalarials. We evaluated the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) as a point-of-care tool for screening G6PD deficiency. A cross-sectional study was conducted among 206 randomly selected and consented participants from a group with known G6PD deficiency status between February 2013 and June 2013. A maximum of 1.6ml of capillary blood samples were used for G6PD deficiency screening using CareStart G6PD RDT and Trinity qualitative with Trinity quantitative methods as the "gold standard". Samples were also screened for the presence of malaria parasites. Data entry and analysis were done using Microsoft Access 2010 and Stata Software version 12. Kintampo Health Research Centre Institutional Ethics Committee granted ethical approval. The sensitivity (SE) and specificity (SP) of CareStart G6PD deficiency RDT was 100% and 72.1% compared to Trinity quantitative method respectively and was 98.9% and 96.2% compared to Trinity qualitative method. Malaria infection status had no significant (P=0.199) change on the performance of the G6PD RDT test kit compared to the "gold standard". The outcome of this study suggests that the diagnostic performance of the CareStart G6PD deficiency RDT kit was high and it is acceptable at determining the G6PD deficiency status in a high malaria endemic area in Ghana. The RDT kit presents as an attractive tool for point-of-care G6PD deficiency for rapid testing in areas with high temperatures and less expertise. The CareStart G6PD deficiency RDT kit could be used to screen malaria patients before administration of the fixed dose primaquine with artemisinin-based combination therapy.

  11. Characterization of groundwater resources in the Trinity and Woodbine aquifers in Texas.

    PubMed

    Chaudhuri, Sriroop; Ale, Srinivasulu

    2013-05-01

    A vast region in north-central Texas, centering on Dallas-Fort Worth metroplex, suffers from intense groundwater drawdown and water quality degradation, which led to inclusion of 18 counties of this region into Priority Groundwater Management Areas. We combined aquifer-based and county-based hydrologic analyses to (1) assess spatio-temporal changes in groundwater level and quality between 1960 and 2010 in the Trinity and Woodbine aquifers underlying the study region, (2) delve into major hydrochemical facies with reference to aquifer hydrostratigraphy, and (3) identify county-based spatial zones to aid in future groundwater management initiatives. Water-level and quality data was obtained from the Texas Water Development Board (TWDB) and analyzed on a decadal scale. Progressive water-level decline was the major concern in the Trinity aquifer with >50% of observations occurring at depths >100 m since the 1980s, an observation becoming apparent only in the 2000s in the Woodbine aquifer. Water quality degradation was the major issue in the Woodbine aquifer with substantially higher percentage of observations exceeding the secondary maximum contaminant levels (SMCL; a non-enforceable threshold set by the United State Environmental Protection Agency (USEPA)) and/or maximum contaminant level (MCL, a legally enforceable drinking water standard set by the USEPA) for sulfate (SO4(2-)), chloride (Cl(-)), and fluoride (F(-)) in each decade. In both aquifers, however, >70% of observations exceeded the SMCL for total dissolved solids indicating high groundwater salinization. Water-level changes in Trinity aquifer also had significant negative impact on water quality. Hydrochemical facies in this region sequentially evolved from Ca-Mg-HCO3 and Ca-HCO3 in the fluvial sediments of the west to Na-SO4-Cl in the deltaic sediments to the east. Sequentially evolving hydrogeochemical facies and increasing salinization closely resembled regional groundwater flow pattern. Distinct spatial zones based on homogenous hydrologic characteristics have become increasingly apparent over time indicating necessity of zone-specific groundwater management strategies. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. Effectiveness of the U.S. National HIV Testing Day Campaigns in Promoting HIV Testing: Evidence from CDC-Funded HIV Testing Sites, 2010

    PubMed Central

    Mulatu, Mesfin S.

    2014-01-01

    Objectives We assessed if HIV testing and diagnoses increased during the week of National HIV Testing Day (NHTD) and if characteristics of people who were tested varied compared with control weeks. Methods We analyzed HIV testing data from the 2010 National HIV Prevention Program Monitoring and Evaluation system to compare NHTD week (June 24–30, 2010) with two control weeks (January 7–13, 2010, and August 12–18, 2010) for the number of HIV testing events and new HIV-positive diagnoses, by demographics and other HIV-related variables. Characteristics associated with testing during NHTD week compared with control weeks were identified using Chi-square analyses. Results In 2010, an average of 15,000 more testing events were conducted and 100 more new HIV-positive diagnoses were identified during NHTD week than during the control weeks (p<0.001). Compared with control weeks, people tested during NHTD week were significantly less likely to be aged 20–29 years and non-Hispanic white and significantly more likely to be (1) aged ≥50 years, (2) non-Hispanic black or African American, (3) men who have sex with men, (4) low-risk heterosexuals, (5) tested with a rapid HIV test, or (6) tested in a non-health-care setting. Conclusion In 2010, CDC-funded HIV testing events and new HIV-positive diagnoses increased during NHTD week compared with control weeks. HIV testing programs increased the use of rapid tests and returned a high percentage of test results. NHTD campaigns reached populations disproportionately affected by HIV and further expanded testing to people traditionally less likely to be tested. Incorporating strategies used during NHTD in programs conducted throughout the year may assist in increasing HIV testing and the number of HIV-positive diagnoses. PMID:25177056

  13. Impact of HIV Infection on Diastolic Function and Left Ventricular Mass

    PubMed Central

    Hsue, Priscilla Y.; Hunt, Peter W.; Ho, Jennifer E.; Farah, Husam H.; Schnell, Amanda; Hoh, Rebecca; Martin, Jeffrey N.; Deeks, Steven G.; Bolger, Ann F.

    2010-01-01

    Background HIV patients have increased risk for cardiovascular disease, but the underlying mechanisms remain unknown. The purpose of this study was to determine the prevalence of echocardiographic abnormalities among asymptomatic HIV-infected individuals compared to HIV-uninfected individuals. Methods/Results We performed echocardiography in 196 HIV-infected adults and 52 controls. Left ventricular ejection fraction (LVEF), left ventricular mass indexed to the body surface area (LVMI), and diastolic function were assessed according to American Society of Echocardiography standards. LVMI was higher in HIV-infected patients (77.2g/m2 in HIV patients vs. 66.5g/m2 in controls, p<0.0001). LVEF was similar in both groups. Eight(4%) of the HIV patients had evidence of LV systolic dysfunction (defined as an EF<50%) versus none of the controls; 97(50%) had mild diastolic dysfunction compared to 29% of the HIV-uninfected subjects (p=0.008). After adjustment for hypertension and race, HIV-infected participants had a mean 8g/m2 larger LVMI compared to controls (p=0.001). Higher LVMI was independently associated with lower nadir CD4 T cell count, suggesting that immunodeficiency may play a role in this process. After adjustment for age and traditional risk factors, HIV patients had a 2.4 greater odds of having diastolic dysfunction as compared to controls (p=0.019). Conclusions HIV-infected patients had a higher prevalence of diastolic dysfunction and higher LVMI compared to controls. These differences were not readily explained by differences in traditional risk factors and were independently associated with HIV infection. These results suggest that contemporary asymptomatic HIV patients manifest mild functional and morphological cardiac abnormalities which are independently associated with HIV infection. PMID:19933410

  14. A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers.

    PubMed

    Claireaux, M; Galperin, M; Benati, D; Nouël, A; Mukhopadhyay, M; Klingler, J; de Truchis, P; Zucman, D; Hendou, S; Boufassa, F; Moog, C; Lambotte, O; Chakrabarti, L A

    2018-05-08

    Follicular helper T cells (Tfh) play an essential role in the affinity maturation of the antibody response by providing help to B cells. To determine whether this CD4 + T cell subset may contribute to the spontaneous control of HIV infection, we analyzed the phenotype and function of circulating Tfh (cTfh) in patients from the ANRS CO21 CODEX cohort who naturally controlled HIV-1 replication to undetectable levels and compared them to treated patients with similarly low viral loads. HIV-specific cTfh (Tet + ), detected by Gag-major histocompatibility complex class II (MHC-II) tetramer labeling in the CD45RA - CXCR5 + CD4 + T cell population, proved more frequent in the controller group ( P = 0.002). The frequency of PD-1 expression in Tet + cTfh was increased in both groups (median, >75%) compared to total cTfh (<30%), but the intensity of PD-1 expression per cell remained higher in the treated patient group ( P = 0.02), pointing to the persistence of abnormal immune activation in treated patients. The function of cTfh, analyzed by the capacity to promote IgG secretion in cocultures with autologous memory B cells, did not show major differences between groups in terms of total IgG production but proved significantly more efficient in the controller group when measuring HIV-specific IgG production. The frequency of Tet + cTfh correlated with HIV-specific IgG production ( R = 0.71 for Gag-specific and R = 0.79 for Env-specific IgG, respectively). Taken together, our findings indicate that key cTfh-B cell interactions are preserved in controlled HIV infection, resulting in potent memory B cell responses that may play an underappreciated role in HIV control. IMPORTANCE The rare patients who spontaneously control HIV replication in the absence of therapy provide a unique model to identify determinants of an effective anti-HIV immune response. HIV controllers show signs of particularly efficient antiviral T cell responses, while their humoral response was until recently considered to play only a minor role in viral control. However, emerging evidence suggests that HIV controllers maintain a significant but "silent" antiviral memory B cell population that can be reactivated upon antigenic stimulation. We report that cTfh help likely contributes to the persistence of controller memory B cell responses, as the frequency of HIV-specific cTfh correlated with the induction of HIV-specific antibodies in functional assays. These findings suggest that T follicular help may contribute to HIV control and highlight the need for inducing such help in HIV vaccine strategies that aim at eliciting persistent B cell responses. Copyright © 2018 Claireaux et al.

  15. Mindfulness instruction for HIV-infected youth: a randomized controlled trial.

    PubMed

    Webb, Lindsey; Perry-Parrish, Carisa; Ellen, Jonathan; Sibinga, Erica

    2018-06-01

    HIV-infected youth experience many stressors, including stress related to their illness, which can negatively impact their mental and physical health. Therefore, there is a significant need to identify potentially effective interventions to improve stress management, coping, and self-regulation. The object of the study was to assess the effect of a mindfulness-based stress reduction (MBSR) program compared to an active control group on psychological symptoms and HIV disease management in youth utilizing a randomized controlled trial. Seventy-two HIV-infected adolescents, ages 14-22 (mean age 18.71 years), were enrolled from two urban clinics and randomized to MBSR or an active control. Data were collected on mindfulness, stress, self-regulation, psychological symptoms, medication adherence, and cognitive flexibility at baseline, post-program, and 3-month follow-up. CD4+ T lymphocyte and HIV viral load (HIV VL) counts were also pulled from medical records. HIV-infected youth in the MBSR group reported higher levels of mindfulness (P = .03), problem-solving coping (P = .03), and life satisfaction (P = .047), and lower aggression (P = .002) than those in the control group at the 3-month follow-up. At post-program, MBSR participants had higher cognitive accuracy when faced with negative emotion stimuli (P = .02). Also, those in the MBSR study arm were more likely to have or maintain reductions in HIV VL at 3-month follow-up than those in the control group (P = .04). In our sample, MBSR instruction proved beneficial for important psychological and HIV-disease outcomes, even when compared with an active control condition. Lower HIV VL levels suggest improved HIV disease control, possibly due to higher levels of HIV medication adherence, which is of great significance in both HIV treatment and prevention. Additional research is needed to explore further the role of MBSR for improving the psychological and physical health of HIV-positive youth.

  16. The impact of human immune deficiency virus and hepatitis C coinfection on white matter microstructural integrity.

    PubMed

    Heaps-Woodruff, J M; Wright, P W; Ances, B M; Clifford, D; Paul, R H

    2016-06-01

    The purpose of the present study is to examine the integrity of white matter microstructure among individuals coinfected with HIV and HCV using diffusion tensor imaging (DTI). Twenty-five HIV+ patients, 21 HIV+/HCV+ patients, and 25 HIV- controls were included in this study. All HIV+ individuals were stable on combination antiretroviral therapy (cART; ≥3 months). All participants completed MRI and neuropsychological measures. Clinical variables including liver function, HIV-viral load, and CD4 count were collected from the patient groups. DTI metrics including mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) from five subregions of the corpus callosum were compared across groups. The HIV+/HCV+ group and HIV+ group were similar in terms of HIV clinical variables. None of the participants met criteria for cirrhosis or fibrosis. Within the anterior corpus callosum, significant differences were observed between both HIV+ groups compared to HIV- controls on DTI measures. HIV+ and HIV+/HCV+ groups had significantly lower FA values and higher MD and RD values compared to HIV- controls; however, no differences were present between the HIV+ and HIV+/HCV+ groups. Duration of HIV infection was significantly related to DTI metrics in total corpus callosum FA only, but not other markers of HIV disease burden or neurocognitive function. Both HIV+ and HIV+/HCV+ individuals had significant alterations in white matter integrity within the corpus callosum; however, there was no evidence for an additive effect of HCV coinfection. The association between DTI metrics and duration of HIV infection suggests that HIV may continue to negatively impact white matter integrity even in well-controlled disease.

  17. Working Memory Profiles in HIV-Exposed, Uninfected and HIV-Infected Children: A Comparison with Neurotypical Controls

    PubMed Central

    Milligan, Robyn; Cockcroft, Kate

    2017-01-01

    This study compared the working memory profiles of three groups of children, namely HIV-infected (HIV-I; n = 95), HIV-exposed, uninfected (HIV-EU; n = 86) and an HIV-unexposed, uninfected, (HIV-UU; n = 92) neurotypical control group. Working memory, an executive function, plays an important role in frontal lobe-controlled behaviors, such as motivation, planning, decision making, and social interaction, and is a strong predictor of academic success in school children. Memory impairments have been identified in HIV-I children, particularly in visuospatial processing. Verbal working memory has not been commonly investigated in this population, while it is unknown how the working memory profiles of HIV-EU children compare to their HIV-I and HIV-UU peers. Of interest was whether the working memory profiles of the HIV-EU children would be more similar to the HIV-I group or to the uninfected control group. The results revealed no significant differences in working memory performance between the HIV-I and HIV-EU groups. However, this does not mean that the etiology of the working memory deficits is the same in the two groups, as these groups showed important differences when compared to the control group. In comparison to the controls, the HIV-I group experienced difficulties with processing tasks irrespective of whether they drew on a verbal or visuospatial modality. This appears to stem from a generalized executive function deficit that also interferes with working memory. In the HIV-EU group, difficulties occurred with verbally based tasks, irrespective of whether they required storage or processing. For this group, the dual demands of complex processing and using a second language seem to result in demand exceeding capacity on verbal tasks. Both groups experienced the greatest difficulties with verbal processing tasks for these different reasons. Thus, disruption of different cognitive abilities could result in similar working memory profiles, as evidenced in this study. This has implications for the underlying developmental neurobiology of HIV-I and HIV-EU children, as well the choice of appropriate measures to assist affected children. PMID:28729828

  18. Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy.

    PubMed

    Rosen, Elizabeth J; Calhoun, Karen H

    2005-01-01

    To determine if human immunodeficiency virus (HIV) infection is associated with a prolonged mucociliary clearance time (MCT) and to evaluate the effect of guaifenesin on MCT in HIV+ patients. A cross-sectional study comparing HIV+ and HIV- volunteers followed by a prospective, randomized, double-blind, placebo-controlled study of HIV+ patients before and after guaifenesin treatment. Twenty-five HIV+ patients and 29 HIV- controls were enrolled and MCT was measured using the saccharin method. A separate group of 20 HIV+ patients participated in the second arm of the study and underwent saccharin testing before and after a 3-week course of guaifenesin or placebo. All study participants completed a medical history questionnaire, a sinonasal symptom (SNOT-16) survey, and were examined with both anterior rhinoscopy and rigid nasal endoscopy. There was a significant difference (P < .002) in the MCT between the HIV+ group (13.3 +/- SD 7.5 minutes) and the HIV- controls (9.2 +/- SD 3.9 minutes). The difference in MCT between the guaifenesin and placebo groups did not reach statistical significance (P >.05). The HIV+ group had a higher SNOT-16 score compared to HIV- controls (21.1 vs. 7.4, P < .001). Guaifenesin therapy in HIV+ patients led to a significant improvement in the SNOT-16 score (P < .05). Compared to HIV- controls, HIV+ patients have a prolonged MCT and more sinonasal symptoms as indicated by a higher SNOT-16 score. Guaifenesin therapy was associated with improved SNOT-16 scores, although there was not a detectable improvement in MCT. Use of guaifenesin in HIV+ patients with sinonasal disease may lead to improved patient perception of quality of life.

  19. Cardiovagal Autonomic Function in HIV-Infected Patients with Unsuppressed HIV Viremia

    PubMed Central

    Chow, Dominic C.; Wood, Robert; Choi, Julia; Grandinetti, Andrew; Gerschenson, Mariana; Sriratanaviriyakul, Narin; Nakamoto, Beau; Shikuma, Cecilia; Low, Phillip

    2011-01-01

    Purpose HIV infection has been implicated in dysregulation of the autonomic nervous system. Method Cross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV. Results 57 participants were enrolled in 3 groups: 22 were HIV-infected participants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups. Conclusion There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups. PMID:21684854

  20. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes.

    PubMed

    Murakoshi, Hayato; Akahoshi, Tomohiro; Koyanagi, Madoka; Chikata, Takayuki; Naruto, Takuya; Maruyama, Rie; Tamura, Yoshiko; Ishizuka, Naoki; Gatanaga, Hiroyuki; Oka, Shinichi; Takiguchi, Masafumi

    2015-05-01

    Identification and characterization of CD8(+) T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis, although such CD8(+) T cells have been only partially identified. In this study, we sought to identify CD8(+) T cells controlling HIV-1 variants in 401 Japanese individuals chronically infected with HIV-1 subtype B, in which protective alleles HLA-B*57 and HLA-B*27 are very rare, by using comprehensive and exhaustive methods. We identified 13 epitope-specific CD8(+) T cells controlling HIV-1 in Japanese individuals, though 9 of these epitopes were not previously reported. The breadths of the T cell responses to the 13 epitopes were inversely associated with plasma viral load (P = 2.2 × 10(-11)) and positively associated with CD4 count (P = 1.2 × 10(-11)), indicating strong synergistic effects of these T cells on HIV-1 control in vivo. Nine of these epitopes were conserved among HIV-1 subtype B-infected individuals, whereas three out of four nonconserved epitopes were cross-recognized by the specific T cells. These findings indicate that these 12 epitopes are strong candidates for antigens for an AIDS vaccine. The present study highlighted a strategy to identify CD8(+) T cells controlling HIV-1 and demonstrated effective control of HIV-1 by those specific for 12 conserved or cross-reactive epitopes. HLA-B*27-restricted and HLA-B*57-restricted cytotoxic T lymphocytes (CTLs) play a key role in controlling HIV-1 in Caucasians and Africans, whereas it is unclear which CTLs control HIV-1 in Asian countries, where HLA-B*57 and HLA-B*27 are very rare. A recent study showed that HLA-B*67:01 and HLA-B*52:01-C*12:02 haplotypes were protective alleles in Japanese individuals, but it is unknown whether CTLs restricted by these alleles control HIV-1. In this study, we identified 13 CTLs controlling HIV-1 in Japan by using comprehensive and exhaustive methods. They included 5 HLA-B*52:01-restricted and 3 HLA-B*67:01-restricted CTLs, suggesting that these CTLs play a predominant role in HIV-1 control. The 13 CTLs showed synergistic effects on HIV-1 control. Twelve out of these 13 epitopes were recognized as conserved or cross-recognized ones. These findings strongly suggest that these 12 epitopes are candidates for antigens for AIDS vaccines. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  1. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes

    PubMed Central

    Murakoshi, Hayato; Akahoshi, Tomohiro; Koyanagi, Madoka; Chikata, Takayuki; Naruto, Takuya; Maruyama, Rie; Tamura, Yoshiko; Ishizuka, Naoki; Gatanaga, Hiroyuki; Oka, Shinichi

    2015-01-01

    ABSTRACT Identification and characterization of CD8+ T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis, although such CD8+ T cells have been only partially identified. In this study, we sought to identify CD8+ T cells controlling HIV-1 variants in 401 Japanese individuals chronically infected with HIV-1 subtype B, in which protective alleles HLA-B*57 and HLA-B*27 are very rare, by using comprehensive and exhaustive methods. We identified 13 epitope-specific CD8+ T cells controlling HIV-1 in Japanese individuals, though 9 of these epitopes were not previously reported. The breadths of the T cell responses to the 13 epitopes were inversely associated with plasma viral load (P = 2.2 × 10−11) and positively associated with CD4 count (P = 1.2 × 10−11), indicating strong synergistic effects of these T cells on HIV-1 control in vivo. Nine of these epitopes were conserved among HIV-1 subtype B-infected individuals, whereas three out of four nonconserved epitopes were cross-recognized by the specific T cells. These findings indicate that these 12 epitopes are strong candidates for antigens for an AIDS vaccine. The present study highlighted a strategy to identify CD8+ T cells controlling HIV-1 and demonstrated effective control of HIV-1 by those specific for 12 conserved or cross-reactive epitopes. IMPORTANCE HLA-B*27-restricted and HLA-B*57-restricted cytotoxic T lymphocytes (CTLs) play a key role in controlling HIV-1 in Caucasians and Africans, whereas it is unclear which CTLs control HIV-1 in Asian countries, where HLA-B*57 and HLA-B*27 are very rare. A recent study showed that HLA-B*67:01 and HLA-B*52:01-C*12:02 haplotypes were protective alleles in Japanese individuals, but it is unknown whether CTLs restricted by these alleles control HIV-1. In this study, we identified 13 CTLs controlling HIV-1 in Japan by using comprehensive and exhaustive methods. They included 5 HLA-B*52:01-restricted and 3 HLA-B*67:01-restricted CTLs, suggesting that these CTLs play a predominant role in HIV-1 control. The 13 CTLs showed synergistic effects on HIV-1 control. Twelve out of these 13 epitopes were recognized as conserved or cross-recognized ones. These findings strongly suggest that these 12 epitopes are candidates for antigens for AIDS vaccines. PMID:25741000

  2. Examples of Mass Wasting and Hemipelagic Sedimentation of Brazos-Trinity Basin #4 and Ursa Basin, Northern Gulf of Mexico

    NASA Astrophysics Data System (ADS)

    Schneider, J.; Moerz, T.; Bartetzko, A.; Iturrino, G. J.; Edeskar, T. M.; Flemings, P. B.; Behrmann, J. H.; John, C. M.

    2005-12-01

    Pleistocene sea level changes influenced the sedimentation history on the passive continental margin of the northern Gulf of Mexico coast. During IODP Expedition 308, the Brazos-Trinity #4 and Ursa Basin were drilled to study -overpressure, fluid flow and deformation processes in a passive margin setting. The Brazos-Trinity Basin #4 is located 200 km south of Galveston, Texas (USA) in ~1400 m water depth below an extended shelf section. Ursa Basin is located 150 km south of New Orleans, Louisiana (USA) in ~1000 m water depth south of the Mississippi river mouth. Despite their similar geotectonic setting both basins show fundamental differences in their style of mass wasting and drape sedimentation. Here we use core descriptions, core photographs, Formation MicroScanner (FMS) data and selected physical properties measurements (magnetic susceptibility, GRAPE density) to illustrate and compare styles of mass wasting and drape sedimentation on selected intervals for the first 4 Marine Isotope Stages. Special emphasis is given to the thickness and frequency of single depositional events. One aim is to estimate the mass wasting / hemipelagic accumulation ratio for both basins and compare it to the average sedimentation rates based on the preliminary shipboard age models. This information will be used in the future to study how sedimentation processes control permeability and pore pressure. In this upcoming project, starting in mid 2006, will use well-logging data to compute continuous porosity, permeability, and pore pressure profiles. These computations require input and reference data obtained from petrophysical and geotechnical core analyses and in situ measurements (e.g. matrix density to calculate porosity from the density log, permeability and porosity to derive porosity-permeability relations, effective stress to calculate pore pressure). Permeability and effective stress will be measured using oedometer tests on undisturbed samples. The detailed lithostratigraphic information, particularly turbidite thickness, and the permeability and pore pressure profiles will be used as input data for one-dimensional modeling of the compression history of two Sites using the civil engineering modeling software PLAXIS.

  3. A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolution™) with a comparison to historical controls.

    PubMed

    Vanichkachorn, Jed; Peppers, Timothy; Bullard, Dennis; Stanley, Scott K; Linovitz, Raymond J; Ryaby, James T

    2016-07-01

    This multicenter clinical study was performed to assess the safety and effectiveness of Trinity Evolution(®) (TE), a viable cellular bone allograft, in combination with a PEEK interbody spacer and supplemental anterior fixation in patients undergoing anterior cervical discectomy and fusion (ACDF). In a prospective, multi-center study, 31 patients that presented with symptomatic cervical degeneration at one vertebral level underwent ACDF with a PEEK interbody spacer (Orthofix, Inc., Lewisville, TX, USA) and supplemental anterior fixation. In addition all patients had the bone graft substitute, Trinity Evolution (Musculoskeletal Transplant Foundation, Edison, NJ, USA), placed within the interbody spacer. At 6 and 12 months, radiographic fusion was evaluated as determined by independent radiographic review of angular motion (≤4°) from flexion/extension X-rays combined with presence of bridging bone across the adjacent endplates on thin cut CT scans. In addition other metrics were measured including function as assessed by the Neck Disability Index (NDI), and neck and arm pain as assessed by individual Visual Analog Scales (VAS). The fusion rate for patients using a PEEK interbody spacer in combination with TE was 78.6 % at 6 months and 93.5 % at 12 months. When considering high risk factors, 6-month fusion rates for patients that were current or former smokers, diabetic, overweight or obese/extremely obese were 70 % (7/10), 100 % (1/1), 70 % (7/10), and 82 % (9/11), respectively. At 12 months, the fusion rates were 100 % (12/12), 100 % (2/2), 100 % (11/11) and 85 % (11/13), respectively. Neck function, and neck/arm pain were found to significantly improve at both time points. No serious allograft related adverse events occurred and none of the 31 patients had subsequent additional cervical surgeries. Patients undergoing single-level ACDF with TE in combination with a PEEK interbody spacer and supplemental anterior fixation had a high rate of fusion success without serious allograft-related adverse events.

  4. Trinity Phase 2 Open Science: CTH

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ruggirello, Kevin Patrick; Vogler, Tracy

    CTH is an Eulerian hydrocode developed by Sandia National Laboratories (SNL) to solve a wide range of shock wave propagation and material deformation problems. Adaptive mesh refinement is also used to improve efficiency for problems with a wide range of spatial scales. The code has a history of running on a variety of computing platforms ranging from desktops to massively parallel distributed-data systems. For the Trinity Phase 2 Open Science campaign, CTH was used to study mesoscale simulations of the hypervelocity penetration of granular SiC powders. The simulations were compared to experimental data. A scaling study of CTH up tomore » 8192 KNL nodes was also performed, and several improvements were made to the code to improve the scalability.« less

  5. Conformational Transitions in Molecular Systems

    NASA Astrophysics Data System (ADS)

    Bachmann, M.; Janke, W.

    2008-11-01

    Proteins are the "work horses" in biological systems. In almost all functions specific proteins are involved. They control molecular transport processes, stabilize the cell structure, enzymatically catalyze chemical reactions; others act as molecular motors in the complex machinery of molecular synthetization processes. Due to their significance, misfolds and malfunctions of proteins typically entail disastrous diseases, such as Alzheimer's disease and bovine spongiform encephalopathy (BSE). Therefore, the understanding of the trinity of amino acid composition, geometric structure, and biological function is one of the most essential challenges for the natural sciences. Here, we glance at conformational transitions accompanying the structure formation in protein folding processes.

  6. An investigation of the effects of antiretroviral central nervous system penetration effectiveness on procedural learning in HIV+ drug users.

    PubMed

    Wilson, Michael J; Martin-Engel, Lindsay; Vassileva, Jasmin; Gonzalez, Raul; Martin, Eileen M

    2013-01-01

    Treatment with combination antiretroviral therapy (cART) regimens with a high capacity to penetrate the blood-brain barrier has been associated with lower levels of human immunodeficiency virus (HIV) in the central nervous system (CNS). This study examined neurocognitive performance among a sample of 118 HIV+ substance-dependent individuals (SDIs) and 310 HIV- SDIs. HIV+ participants were prescribed cART regimens with varying capacity to penetrate the CNS as indexed by the revised CNS Penetration Effectiveness (CPE) scale. Participants completed the Rotary Pursuit Task (RPT) and the Weather Prediction Task (WPT)-two measures of procedural learning (PL) with known sensitivity to HIV infection-and a control task of sustained attention. HIV+ SDIs prescribed cART with relatively high CNS penetrance performed significantly more poorly on both tasks than HIV- controls. Task performance of HIV+ SDIs prescribed cART with relatively low CNS penetrance did not differ significantly from either HIV- controls or the HIV+/high CPE group, although a trend toward lower RPT performance than that of HIV- participants was observed. Between-group differences were not seen on a control task of motor impulsivity (Immediate Memory Task), indicating that the observed deficits among HIV+/high CPE SDIs may have some specificity.

  7. Mental health treatment patterns in perinatally HIV-infected youth and controls.

    PubMed

    Chernoff, Miriam; Nachman, Sharon; Williams, Paige; Brouwers, Pim; Heston, Jerry; Hodge, Janice; Di Poalo, Vinnie; Deygoo, Nagamah Sandra; Gadow, Kenneth D

    2009-08-01

    Youths perinatally infected with HIV often receive psychotropic medication and behavioral treatment for emotional and behavioral symptoms. We describe patterns of intervention for HIV-positive youth and youth in a control group in the United States. Three hundred nineteen HIV-positive youth and 256 controls, aged 6 to 17 years, enrolled in the International Maternal Adolescent AIDS Clinical Trials 1055, a prospective, 2-year observational study of psychiatric symptoms. One hundred seventy-four youth in the control group were perinatally exposed to HIV, and 82 youth were uninfected children living in households with HIV-positive members. Youth and their primary caregivers completed Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-referenced symptom-rating scales. Children's medication and behavioral psychiatric intervention histories were collected at entry. We evaluated the association of past or current psychiatric treatment with HIV status, baseline symptoms, and impairment by using multiple logistic regression, controlling for potential confounders. HIV-positive youth and youth in the control group had a similar prevalence of psychiatric symptoms (61%) and impairment (14% to 15%). One hundred four (18%) participants received psychotropic medications (stimulants [14%], antidepressants [6%], and neuroleptic agents [4%]), and 127 (22%) received behavioral treatment. More HIV-positive youth than youth in the control group received psychotropic medication (23% vs 12%) and behavioral treatment (27% vs 17%). After adjusting for symptom class and confounders, HIV-positive children had twice the odds of children in the control group of having received stimulants and >4 times the odds of having received antidepressants. Caregiver-reported symptoms or impairment were associated with higher odds of intervention than reports by children alone. HIV-positive children are more likely to receive mental health interventions than control-group children. Pediatricians and caregivers should consider available mental health treatment options for all children living in families affected by HIV.

  8. Evaluation of Trinity Evolution in Patients Undergoing Foot and Ankle Fusion

    ClinicalTrials.gov

    2014-04-07

    Tibiotalar Arthrodesis; Subtalar Arthrodesis; Calcaneocuboid Arthrodesis; Talonavicular Arthrodesis; Double Arthrodesis (i.e. Calcaneocuboid and Talonavicular); Triple Arthrodesis (i.e. Subtalar, Calcaneocuboid, and Talonavicular)

  9. TB/HIV Co-Infection Care in Conflict-Affected Settings: A Mapping of Health Facilities in the Goma Area, Democratic Republic of Congo

    PubMed Central

    Kaboru, Berthollet Bwira; Ogwang, Brenda. A.; Namegabe, Edmond Ntabe; Mbasa, Ndemo; Kabunga, Deka Kambale; Karafuli, Kambale

    2013-01-01

    Background: HIV/AIDS and Tuberculosis (TB) are major contributors to the burden of disease in sub-Saharan Africa. The two diseases have been described as a harmful synergy as they are biologically and epidemiologically linked. Control of TB/HIV co-infection is an integral and most challenging part of both national TB and national HIV control programmes, especially in contexts of instability where health systems are suffering from political and social strife. This study aimed at assessing the provision of HIV/TB co-infection services in health facilities in the conflict-ridden region of Goma in Democratic Republic of Congo. Methods: A cross-sectional survey of health facilities that provide either HIV or TB services or both was carried out. A semi-structured questionnaire was used to collect the data which was analysed using descriptive statistics. Results: Eighty facilities were identified, of which 64 facilities were publicly owned. TB care was more available than HIV care (in 61% vs. 9% of facilities). Twenty-three facilities (29%) offered services to co-infected patients. TB/HIV co-infection rates among patients were unknown in 82% of the facilities. Only 19 facilities (24%) reported some coordination with and support from concerned diseases’ control programmes. HIV and TB services are largely fragmented, indicating imbalances and poor coordination by disease control programmes. Conclusion: HIV and TB control appear not to be the focus of health interventions in this crisis affected region, despite the high risks of TB and HIV infection in the setting. Comprehensive public health response to this setting calls for reforms that promote joint TB/HIV co-infection control, including improved leadership by the HIV programmes that accuse weaknesses in this conflict-ridden region. PMID:24596866

  10. TB/HIV Co-Infection Care in Conflict-Affected Settings: A Mapping of Health Facilities in the Goma Area, Democratic Republic of Congo.

    PubMed

    Kaboru, Berthollet Bwira; Ogwang, Brenda A; Namegabe, Edmond Ntabe; Mbasa, Ndemo; Kabunga, Deka Kambale; Karafuli, Kambale

    2013-09-01

    HIV/AIDS and Tuberculosis (TB) are major contributors to the burden of disease in sub-Saharan Africa. The two diseases have been described as a harmful synergy as they are biologically and epidemiologically linked. Control of TB/HIV co-infection is an integral and most challenging part of both national TB and national HIV control programmes, especially in contexts of instability where health systems are suffering from political and social strife. This study aimed at assessing the provision of HIV/TB co-infection services in health facilities in the conflict-ridden region of Goma in Democratic Republic of Congo. A cross-sectional survey of health facilities that provide either HIV or TB services or both was carried out. A semi-structured questionnaire was used to collect the data which was analysed using descriptive statistics. Eighty facilities were identified, of which 64 facilities were publicly owned. TB care was more available than HIV care (in 61% vs. 9% of facilities). Twenty-three facilities (29%) offered services to co-infected patients. TB/HIV co-infection rates among patients were unknown in 82% of the facilities. Only 19 facilities (24%) reported some coordination with and support from concerned diseases' control programmes. HIV and TB services are largely fragmented, indicating imbalances and poor coordination by disease control programmes. HIV and TB control appear not to be the focus of health interventions in this crisis affected region, despite the high risks of TB and HIV infection in the setting. Comprehensive public health response to this setting calls for reforms that promote joint TB/HIV co-infection control, including improved leadership by the HIV programmes that accuse weaknesses in this conflict-ridden region.

  11. Sociodemographic differences among HIV-positive and HIV-negative recently pregnant women in Mexico City: A case-control study.

    PubMed

    Aguilar-Zapata, Daniel; Piñeirúa-Menéndez, Alicia; Volkow-Fernández, Patricia; Rodríguez-Zulueta, Patricia; Ramos-Alamillo, Ubaldo; Cabrera-López, Teresita; Martin-Onraet, Alexandra

    2017-07-01

    National HIV preventive programs in Mexico focus on high-risk groups that do not consider women, apart from prenatal screening. Nonetheless, the epidemic in women is growing, and there is a need to better understand sociodemographic factors in women living with HIV (WLH). We performed a case-control study in Mexico City, including HIV+ and HIV- women with a recent pregnancy to compare their sociodemographic characteristics and describe the circumstances of diagnosis in HIV+ women, as well as prenatal screening frequency in both groups. Fifty cases and 102 controls were interviewed. HIV+ women were more frequently the only economic support of the family (20% vs 0%, P < .0001). Thirty-eight percent of cases had their first pregnancy at ≤18 years, versus 16% of controls (odds ratio 2.47, 95% confidence interval 1.07-5.72, P = .03); 16% of cases had lived in the street; 6% reported transactional sex, versus none of the controls (P < .0001). In the multivariate analysis, there was strong evidence of an association between HIV infection and age at the time of the interview, history of sexually transmitted diseases, substance abuse, history of violence, and civil status. Only 6% of controls were tested for HIV during prenatal follow-up. WLH in this study faced important social vulnerability. Targeting women living in these social contexts might increase early diagnosis and could tailor HIV prevention strategies. Prenatal coverage needs to be improved and should represent a national priority.

  12. HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection

    PubMed Central

    Laher, Faatima; Ranasinghe, Srinika; Porichis, Filippos; Mewalal, Nikoshia; Pretorius, Karyn; Ismail, Nasreen; Buus, Søren; Stryhn, Anette; Carrington, Mary; Walker, Bruce D.; Ndung'u, Thumbi

    2017-01-01

    ABSTRACT Immune control of viral infections is heavily dependent on helper CD4+ T cell function. However, the understanding of the contribution of HIV-specific CD4+ T cell responses to immune protection against HIV-1, particularly in clade C infection, remains incomplete. Recently, major histocompatibility complex (MHC) class II tetramers have emerged as a powerful tool for interrogating antigen-specific CD4+ T cells without relying on effector functions. Here, we defined the MHC class II alleles for immunodominant Gag CD4+ T cell epitopes in clade C virus infection, constructed MHC class II tetramers, and then used these to define the magnitude, function, and relation to the viral load of HIV-specific CD4+ T cell responses in a cohort of untreated HIV clade C-infected persons. We observed significantly higher frequencies of MHC class II tetramer-positive CD4+ T cells in HIV controllers than progressors (P = 0.0001), and these expanded Gag-specific CD4+ T cells in HIV controllers showed higher levels of expression of the cytolytic proteins granzymes A and B. Importantly, targeting of the immunodominant Gag41 peptide in the context of HLA class II DRB1*1101 was associated with HIV control (r = −0.5, P = 0.02). These data identify an association between HIV-specific CD4+ T cell targeting of immunodominant Gag epitopes and immune control, particularly the contribution of a single class II MHC-peptide complex to the immune response against HIV-1 infection. Furthermore, these results highlight the advantage of the use of class II tetramers in evaluating HIV-specific CD4+ T cell responses in natural infections. IMPORTANCE Increasing evidence suggests that virus-specific CD4+ T cells contribute to the immune-mediated control of clade B HIV-1 infection, yet there remains a relative paucity of data regarding the role of HIV-specific CD4+ T cells in shaping adaptive immune responses in individuals infected with clade C, which is responsible for the majority of HIV infections worldwide. Understanding the contribution of HIV-specific CD4+ T cell responses in clade C infection is particularly important for developing vaccines that would be efficacious in sub-Saharan Africa, where clade C infection is dominant. Here, we employed MHC class II tetramers designed to immunodominant Gag epitopes and used them to characterize CD4+ T cell responses in HIV-1 clade C infection. Our results demonstrate an association between the frequency of HIV-specific CD4+ T cell responses targeting an immunodominant DRB1*11-Gag41 complex and HIV control, highlighting the important contribution of a single class II MHC-peptide complex to the immune response against HIV-1 infections. PMID:28077659

  13. Characterizing the Noble Gas Isotopic Composition of the Barnett Shale and Strawn Group and Constraining the Source of Stray Gas in the Trinity Aquifer, North-Central Texas.

    PubMed

    Wen, Tao; Castro, M Clara; Nicot, Jean-Philippe; Hall, Chris M; Pinti, Daniele L; Mickler, Patrick; Darvari, Roxana; Larson, Toti

    2017-06-06

    This study presents the complete set of stable noble gases for Barnett Shale and Strawn Group production gas together with stray flowing gas in the Trinity Aquifer, Texas. It places new constraints on the source of this stray gas and further shows that Barnett and Strawn gas have distinct crustal and atmospheric noble gas signatures, allowing clear identification of these two sources. Like stray gas, Strawn gas is significantly more enriched in crustal 4 He*, 21 Ne*, and 40 Ar* than Barnett gas. The similarity of Strawn and stray gas crustal noble gas signatures suggests that the Strawn is the source of stray gas in the Trinity Aquifer. Atmospheric 22 Ne/ 36 Ar ratios of stray gas mimic also that of Strawn, further reinforcing the notion that the source of stray gas in this aquifer is the Strawn. While noble gas signatures of Strawn and stray gas are consistent with a single-stage water degassing model, a two-stage oil modified groundwater exsolution fractionation model is required to explain the light atmospheric noble gas signature of Barnett Shale production gas. These distinct Strawn and Barnett noble gas signatures are likely the reflection of distinct evolution histories with Strawn gas being possibly older than that of Barnett Shale.

  14. Geochemical characteristics of Heavy metals of river sediment from the main rivers at Texas, USA.

    NASA Astrophysics Data System (ADS)

    Matsumoto, I.; Hoffman, D.; MacAlister, J.; Ishiga, H.

    2008-12-01

    Trinity River is one of the biggest rivers which flows through Dallas and Fort Worth two big cities of USA and are highly populated. Trinity river drains into the Gulf of Mexico. Sediment samples collected from various points along the upper and lower streams were subjected to content analysis and elution analysis (using liquate (flow) out test) on the heavy metals like Cd, CN, Pb, Cr, As, Hg, Ni, Zn and Cu from the river sediment for the purpose of environment assessment. A total of 22 sample points were identified from upper stream to lower stream and samples were collected such that almost the whole stream length of Trinity River is covered. Results show that heavy metal content through out the river stream is below the recommended limits posing no immediate environmental threat. However, the experimental results show clear impact of human population in bigger cities on heavy metal concentrations in the river sediments as compared to smaller cities with low human population. It could be seen from the analysis that all the heavy metals show relatively high content and high elution value in Dallas and Fort Worth. As we move away from the big cities, the value of content and elution of sediment decreased by natural dilution effect by the river. And we also present the data of the Colorado and San Antonio rivers.

  15. Misconceptions about HIV infection in Kinshasa (Democratic Republic of Congo): a case-control study on knowledge, attitudes and practices.

    PubMed

    Carlos, Silvia; Martínez-González, Miguel Ángel; Burgueño, Eduardo; López-Del Burgo, Cristina; Ruíz-Canela, Miguel; Ndarabu, Adolphe; Tshilolo, Léon; Tshiswaka, Philomène; Labarga, Pablo; de Irala, Jokin

    2015-08-01

    To evaluate the prevalence of HIV-related misconceptions in an outpatient centre of Kinshasa (Democratic Republic of Congo) and analyse the association between these beliefs and HIV infection. A case-control study was carried out from December 2010 until June 2012. We assessed 1630 participants aged 15-49 attending a primary outpatient centre in Kinshasa: 762 HIV Voluntary Counselling and Testing attendees and 868 blood donors. A 59-item questionnaire about knowledge, attitudes and practice was administered during a face-to-face interview, followed by an HIV test. Cases and controls were respondents with a newly diagnosed HIV-positive or HIV-negative test, respectively. Unconditional logistic regression was used to analyse the association between misconceptions and HIV seropositivity. 274 cases and 1340 controls were recruited. Cases were more likely than controls to have a low socioeconomic status, no education, to be divorced/separated or widowed. An association was found between the following variables and HIV seropositivity: having a poor HIV knowledge (adjusted OR=2.79; 95% CI 1.43 to 5.45), not knowing a virus is the cause of AIDS (adjusted OR=2.03; 95% CI 1.38 to 2.98) and reporting more than three HIV-transmission-related misconceptions (adjusted OR=3.30; 95% CI 1.64 to 6.64), such as thinking an HIV-positive person cannot look healthy and that HIV is transmitted by sorcery, God's punishment, a kiss on the mouth, mosquitoes, coughs/sneezes or undercooked food. Despite having access to healthcare services, there are still many people in Kinshasa that have HIV-related misconceptions that increase their HIV risk. Our findings underscore the need for a culturally adapted and gender-orientated basic HIV information into Congolese HIV prevention programmes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. A case-control study of factors associated with HIV infection among black women.

    PubMed

    Forna, Fatu M; Fitzpatrick, Lisa; Adimora, Adaora A; McLellan-Lemal, Eleanor; Leone, Peter; Brooks, John T; Marks, Gary; Greenberg, Alan

    2006-11-01

    To identify social, behavioral and epidemiologic factors associated with HIV infection among HIV-infected and HIV-uninfected black women residing in North Carolina. A case-control study conducted in August 2004 in North Carolina. Cases were 18-40-year-old women with HIV infections diagnosed from 2003-2004. Controls were 18-40-yearold, HIV-negative heterosexually active women recruited from HIV testing sites. Five focus group discussions were also conducted with women not participating in the case-control study. Multivariate analyses of 31 cases and 101 controls showed that HIV-positive women were more likely to receive public assistance [adjusted odds ratio (aOR) 7.3; 95% confidence interval (CI) 2.1, 26.0], to report a history of genital herpes infection (aOR 10.6; 95% CI 2.4, 47.2), and were less likely to have discussed a variety of sexual and behavioral issues relevant to risk of HIV infection with their male partners (aOR 0.6; 95% CI 0.4, 0.8). Focus group participants indicated that financial and social demands created competing challenges for making HIV prevention a priority. Inadequate communication between black women and their sexual partners may create barriers to sexual and behavioral risk reduction. A multidimensional approach that addresses both biological factors such as herpes infection and socioeconomic factors may be needed to reduce HIV transmission in this population.

  17. Disruption of emotion and conflict processing in HIV infection with and without alcoholism comorbidity.

    PubMed

    Schulte, Tilman; Müller-Oehring, Eva M; Sullivan, Edith V; Pfefferbaum, Adolf

    2011-05-01

    Alcoholism and HIV-1 infection each affect components of selective attention and cognitive control that may contribute to deficits in emotion processing based on closely interacting fronto-parietal attention and frontal-subcortical emotion systems. Here, we investigated whether patients with alcoholism, HIV-1 infection, or both diseases have greater difficulty than healthy controls in resolving conflict from emotional words with different valences. Accordingly, patients with alcoholism (ALC, n = 20), HIV-1 infection (HIV, n = 20), ALC + HIV comorbidity (n = 22), and controls (CTL, n = 16) performed an emotional Stroop Match-to-Sample task, which assessed the contribution of emotion (happy, angry) to cognitive control (Stroop conflict processing). ALC + HIV showed greater Stroop effects than HIV, ALC, or CTL for negative (ANGRY) but not for positive (HAPPY) words, and also when the cue color did not match the Stroop stimulus color; the comorbid group performed similarly to the others when cue and word colors matched. Furthermore, emotionally salient face cues prolonged color-matching responses in all groups. HIV alone, compared with the other three groups, showed disproportionately slowed color-matching time when trials featured angry faces. The enhanced Stroop effects prominent in ALC + HIV suggest difficulty in exercising attentional top-down control on processes that consume attentional capacity, especially when cognitive effort is required to ignore negative emotions.

  18. No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau).

    PubMed

    Krut, Jan J; Price, Richard W; Zetterberg, Henrik; Fuchs, Dietmar; Hagberg, Lars; Yilmaz, Aylin; Cinque, Paola; Nilsson, Staffan; Gisslén, Magnus

    2017-07-04

    The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders. With a cross-sectional retrospective design, p-tau, total tau (t-tau), neopterin and HIV-RNA were measured in CSF together with plasma HIV-RNA and blood CD4 + T-cells of 225 HIV-infected patients <50 y of age, subdivided into 3 groups: untreated neuroasymptomatic (NA) (n = 145), on suppressive antiretroviral treatment (cART) (n = 49), and HIV-associated dementia (HAD) (n = 31). HIV-negative healthy subjects served as controls (n = 79). P-tau was not significantly higher in any HIV-infected group compared to HIV-negative controls. Significant increases in t-tau were found as expected in patients with HAD compared to NA, cART, and control groups (p < 0.001 ). P-tau was not higher in HIV-infected patients compared to uninfected controls, thus failing to support a role for premature or accelerated brain aging in HIV infection.

  19. High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV.

    PubMed

    Walline, Heather M; Carey, Thomas E; Goudsmit, Christine M; Bellile, Emily L; D'Souza, Gypsyamber; Peterson, Lisa A; McHugh, Jonathan B; Pai, Sara I; Lee, J Jack; Shin, Dong M; Ferris, Robert L

    2017-02-01

    In this study, high-risk HPV (hrHPV) incidence, prognostic biomarkers, and outcome were assessed in HIV-positive (case) and HIV-negative (control) patients with head and neck squamous cell cancer (HNSCC). HIV-positive cases were matched to controls by tumor site, sex, and age at cancer diagnosis. A tissue microarray (TMA) was constructed and DNA isolated from tumor tissue. MultiPlex-PCR MassArray, L1-PCR, and in situ hybridization were used to assess hrHPV. TMA sections were stained for p16ink4a, TP53, RB, CCND1, EGFR, and scored for intensity and proportion of positive tumor cells. The HNSCC cohort included 41 HIV-positive cases and 41 HIV-negative controls. Tumors from 11 of 40 (28%) cases, and 10 of 41 (24%) controls contained hrHPV. p16 expression, indicative of E7 oncogene activity, was present in 10 of 11 HPV-positive cases and 7 of 10 HPV-positive controls. Low p16 and high TP53 expression in some HPV-positive tumors suggested HPV-independent tumorigenesis. Survival did not differ in cases and controls. RB expression was significantly associated with poor survival (P = 0.01). High TP53 expression exhibited a trend for poorer survival (P = 0.12), but among cases, association with poor survival reached statistical significance (P = 0.04). The proportion of HPV-positive tumors was similar, but the heterogeneity of HPV types was higher in the HIV-positive cases than in HIV-negative controls. High RB expression predicted poor survival, and high TP53 expression was associated with poorer survival in the HIV-positive cases but not HIV-negative controls. HIV infection did not increase risk of death from HNSCC, and HPV-positive tumors continued to be associated with a significantly improved survival, independent of HIV status. Mol Cancer Res; 15(2); 179-88. ©2016 AACR. ©2016 American Association for Cancer Research.

  20. Dendritic Cell Immune Responses in HIV-1 Controllers.

    PubMed

    Martin-Gayo, Enrique; Yu, Xu G

    2017-02-01

    Robust HIV-1-specific CD8 T cell responses are currently regarded as the main correlate of immune defense in rare individuals who achieve natural, drug-free control of HIV-1; however, the mechanisms that support evolution of such powerful immune responses are not well understood. Dendritic cells (DCs) are specialized innate immune cells critical for immune recognition, immune regulation, and immune induction, but their possible contribution to HIV-1 immune defense in controllers remains ill-defined. Recent studies suggest that myeloid DCs from controllers have improved abilities to recognize HIV-1 through cytoplasmic immune sensors, resulting in more potent, cell-intrinsic type I interferon secretion in response to viral infection. This innate immune response may facilitate DC-mediated induction of highly potent antiviral HIV-1-specific T cells. Moreover, protective HLA class I isotypes restricting HIV-1-specific CD8 T cells may influence DC function through specific interactions with innate myelomonocytic MHC class I receptors from the leukocyte immunoglobulin-like receptor family. Bi-directional interactions between dendritic cells and HIV-1-specific T cells may contribute to natural HIV-1 immune control, highlighting the importance of a fine-tuned interplay between innate and adaptive immune activities for effective antiviral immune defense.

  1. HIV infection in pregnancy: maternal and perinatal outcomes in a tertiary care hospital in Calabar, Nigeria.

    PubMed

    Ikpim, Ekott Mabel; Edet, Udo Atim; Bassey, Akpan Ubong; Asuquo, Otu Akaninyene; Inyang, Ekanem Etim

    2016-04-01

    Human immunodeficiency virus (HIV) infection is likely to have untoward effects on pregnancy and its outcome. This study assessed the impact of maternal HIV infection on pregnancy outcomes in a tertiary centre in Calabar, Nigeria. This retrospective study analysed delivery records of 258 HIV-positive and 257 HIV-negative women for pregnancy and delivery complications. Maternal and fetal outcomes of HIV-positive pregnancies were compared with those of HIV-negative controls. Adverse pregnancy outcomes significantly associated with HIV status were: anaemia: 33 (8.1%) vs. 8 (3.1%) in controls; puerperal sepsis: 18 (7%) vs. 2 (0.8%); and low birth weight: 56 (21.7%) vs. 37 (14.4%). Caesarean delivery was higher among HIV-positive women than controls: 96 (37.2%) vs. 58 (22.6%). Preterm births were higher in those HIV cohorts who did not receive antiretroviral therapy (ART): 13 (16.9%) vs. 7 (3.9%). HIV-positive status increased adverse birth outcome of pregnancy. ART appeared to reduce the risk of preterm births in HIV-positive cohorts. © The Author(s) 2015.

  2. [Malaria and HIV infection: clinical and biological aspects at Donka National Hospital in Conakry, Guinea].

    PubMed

    Bald, I; Camara, A; Baldé, O; Magassouba, N F; Bah, M S; Makanéra, A; Gamy, E P

    2010-08-01

    Malaria and HIV/AIDS are two of the most widespread infectious diseases encountered in sub-Saharan Africa. Even minor interactions between these two diseases could have substantial effects on public health. The purpose of this study was to investigate associations between malaria and HIV infection. Study was carried out over an 8-month period (April 1, 2003 to November 30, 2003) in the Tropical and Infectious Diseases Department of the Donka National Hospital in Conakry, Guinea. A total of 89 malaria patients including 41 cases with HIV infection and 48 controls without HIV infection were included. All patients were hospitalized during the study and provided informed consent. Results showed that malaria affected all age groups in the same proportion. Mean patient age was 34 years (range, 15 and 76 years). Males were more frequently infected with a sex ratio of 1.05. The average number of malaria episodes was higher in cases (malaria with HIV-infection than in controls (malaria without HIV infection). Hyperthermia was observed in most cases (68.29%) and controls (77.08%). Severe anemia was observed in 26.82% of cases versus 10.41% of controls. Low parasite density was observed in 73.17% of cases as compared to 68.75% of controls. The recovery rate was higher in the control group than in case group: 27.08% versus 14.63%. The death rate was higher in the case group than in the control group: 21.95% versus 6.25%. These findings demonstrate a link between malaria and HIV. The frequency of malaria episodes was higher in patients with HIV infection than patients without HIV infection and the outcome of malarial episodes was better in patients without HIV infection.

  3. 5. Historic American Buildings Survey, Martin Linsey, Photographer October 2, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Martin Linsey, Photographer October 2, 1966 SOUTHEAST CORNER. - Trinity Episcopal Church, Euclid Avenue & East Twenty-Second Street, Cleveland, Cuyahoga County, OH

  4. HIV-1-RNA in seminal plasma correlates with detection of HIV-1-DNA in semen cells, but not with CMV shedding, among MSM on successful antiretroviral regimens.

    PubMed

    Gantner, Pierre; Assoumou, Lambert; Leruez-Ville, Marianne; David, Ludivine; Suzan-Monti, Marie; Costagliola, Dominique; Rouzioux, Christine; Ghosn, Jade

    2016-11-01

    Intermittent seminal HIV-RNA detection can occur in MSM despite concomitant plasma virological control on combined ART (cART). We undertook the present study to determine if seminal HIV detection was associated with seminal cytomegalovirus (CMV) detection or detection of HIV-infected cells in semen. Longitudinal semen samples from HIV-1-infected MSM on successful cART enrolled in the EVARIST ANRS EP 49 study were analysed. We first conducted a case-control analysis (ratio 1 : 3) to assess HIV-DNA detection in semen cells in the 20 patients with detectable HIV-RNA in seminal plasma (cases) matched with 60 participants with undetectable HIV-RNA (controls) based on total HIV-DNA load in blood cells. Second, we measured CMV-DNA in all seminal plasma samples. HIV-1-DNA in semen cells was detected on at least one sample visit in 12/20 cases and 11/60 controls. Detection of HIV-RNA in seminal plasma was associated significantly with the detection of HIV-DNA in semen cells [OR, 7.6 (95% CI, 2.1-28.4); P = 0.002] when adjusted on total HIV-DNA in blood cells. CMV-DNA was detected in 107/273 seminal plasma samples with a median value of 3.62 log 10 copies/mL (IQR, 2.83-4.38), yielding a prevalence of 39.2%. Seminal CMV-DNA shedding [OR, 1.5 (95% CI, 0.6-3.6); P = 0.343] was not associated with the risk of detection of HIV-RNA in seminal plasma. The presence of HIV-DNA in semen cells was predictive of HIV-RNA detection, suggesting that viral particles arise through local HIV replication by infected semen cells. Despite virological control, compartmentalization of HIV in the genital tract might act in residual replication and transmission. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. WEAVER BALLY ROADLESS AREA, CALIFORNIA.

    USGS Publications Warehouse

    Blake, M.C.; Peters, T.J.

    1984-01-01

    The Weaver Bally Roadless Area includes approximately 22 sq mi in the Shasta-Trinity National Forest, Trinity County, California. A mineral survey indicates that an area of less than 1 sq mi in the northern part of the Weaver Bally Roadless Area has a substantiated mineral-resource potential for gold and silver; a much larger area has a probable mineral-resource potential for the same elements. The geologic terrane precludes the occurrence of fossil fuel resources and there is little promise for the occurrence of additional metallic, energy, or nonmetallic resources in the roadless area. Detailed studies, including further geochemical sampling and drilling could be done in the region of the Globe mines. In addition, the outcrops of dacite porphyry dikes and sills and associated hydrothermal alteration should be mapped in detail.

  6. Importance of relationship context in HIV transmission: results from a qualitative case-control study in Rakai, Uganda.

    PubMed

    Higgins, Jenny A; Mathur, Sanyukta; Eckel, Elizabeth; Kelley, Laura; Kelly, Laura; Nakyanjo, Neema; Sekamwa, Richard; Namatovu, Josephine; Ddaaki, William; Nakubulwa, Rosette; Namakula, Sylvia; Nalugoda, Fred; Santelli, John S

    2014-04-01

    We present results from life history interviews with 60 young adults from southern Uganda. Using a novel qualitative case-control design, we compared newly HIV-positive cases with HIV-negative controls matched on age, gender, marital status, and place of residence. Relationship context was the most salient theme differentiating cases from controls. Compared with HIV-negative respondents, recent seroconverters described relationships marked by poorer communication, greater suspicion and mistrust, and larger and more transitory sexual networks. Results highlight the importance of dyadic approaches to HIV and possibly of couple-based interventions. Using HIV-matched pairs allowed additional understanding of the factors influencing transmission. This hybrid methodological approach holds promise for future studies of sexual health.

  7. Importance of Relationship Context in HIV Transmission: Results From a Qualitative Case-Control Study in Rakai, Uganda

    PubMed Central

    Mathur, Sanyukta; Eckel, Elizabeth; Kelly, Laura; Nakyanjo, Neema; Sekamwa, Richard; Namatovu, Josephine; Ddaaki, William; Nakubulwa, Rosette; Namakula, Sylvia; Nalugoda, Fred; Santelli, John S.

    2014-01-01

    We present results from life history interviews with 60 young adults from southern Uganda. Using a novel qualitative case-control design, we compared newly HIV-positive cases with HIV-negative controls matched on age, gender, marital status, and place of residence. Relationship context was the most salient theme differentiating cases from controls. Compared with HIV-negative respondents, recent seroconverters described relationships marked by poorer communication, greater suspicion and mistrust, and larger and more transitory sexual networks. Results highlight the importance of dyadic approaches to HIV and possibly of couple-based interventions. Using HIV-matched pairs allowed additional understanding of the factors influencing transmission. This hybrid methodological approach holds promise for future studies of sexual health. PMID:24524490

  8. HIV and Child Mental Health: A Case-Control Study in Rwanda

    PubMed Central

    Scorza, Pamela; Kanyanganzi, Frederick; Fawzi, Mary C. Smith; Sezibera, Vincent; Cyamatare, Felix; Beardslee, William; Stulac, Sara; Bizimana, Justin I.; Stevenson, Anne; Kayiteshonga, Yvonne

    2014-01-01

    BACKGROUND: The global HIV/AIDS response has advanced in addressing the health and well-being of HIV-positive children. Although attention has been paid to children orphaned by parental AIDS, children who live with HIV-positive caregivers have received less attention. This study compares mental health problems and risk and protective factors in HIV-positive, HIV-affected (due to caregiver HIV), and HIV-unaffected children in Rwanda. METHODS: A case-control design assessed mental health, risk, and protective factors among 683 children aged 10 to 17 years at different levels of HIV exposure. A stratified random sampling strategy based on electronic medical records identified all known HIV-positive children in this age range in 2 districts in Rwanda. Lists of all same-age children in villages with an HIV-positive child were then collected and split by HIV status (HIV-positive, HIV-affected, and HIV-unaffected). One child was randomly sampled from the latter 2 groups to compare with each HIV-positive child per village. RESULTS: HIV-affected and HIV-positive children demonstrated higher levels of depression, anxiety, conduct problems, and functional impairment compared with HIV-unaffected children. HIV-affected children had significantly higher odds of depression (1.68: 95% confidence interval [CI] 1.15–2.44), anxiety (1.77: 95% CI 1.14–2.75), and conduct problems (1.59: 95% CI 1.04–2.45) compared with HIV-unaffected children, and rates of these mental health conditions were similar to HIV-positive children. These results remained significant after controlling for contextual variables. CONCLUSIONS: The mental health of HIV-affected children requires policy and programmatic responses comparable to HIV-positive children. PMID:25049342

  9. Young adults perinatally infected with HIV perform more poorly on measures of executive functioning and motor speed than ethnically matched healthy controls.

    PubMed

    Willen, Elizabeth J; Cuadra, Anai; Arheart, Kristopher L; Post, M J D; Govind, Varan

    2017-03-01

    Perinatal HIV is associated with significant neurocognitive morbidities, but few studies have examined cognitive impact of early HIV infection on patients surviving to adulthood. The purpose of this study was to evaluate neurocognitive outcomes among a cohort of perinatally infected young adults. Individuals between the ages of 18 and 24 with perinatal infection were recruited for this cross-sectional study along with similarly aged healthy controls. Participants completed an MRI and brief neuropsychological assessment battery. Multivariate analysis of covariance controlling for age, gender, race/ethnicity, and education was completed to detect differences between the HIV+ and control groups. Multivariable linear regression was performed to assess HIV-associated factors potentially impacting neuropsychological findings among the HIV+ group. Twenty-nine HIV+ young adults and 13 healthy controls were included in the study. After adjusting for age and sociodemographic variables, the HIV+ group scored lower on attention/working memory (Digit Span (p = .008) and Letter-Number Sequencing (p = .038)), set-shifting (DKEFS Trail Making Test Condition 4 (p = .026) and motor speed (DKEFS Trail Making Test Condition 5 (p = .003)). For the HIV+ group, nadir CD4 was associated with better Letter-Number Sequencing score (p = .029) and use of highly active antiretroviral therapy was associated with better performance on Category Fluency (p = .040). After controlling for sociodemographic variables, executive dysfunction persists among young adults with perinatal HIV infection in comparison to controls. Future studies to further elucidate the impact of executive dysfunction on independent living and functional outcomes are indicated.

  10. Increased Epicardial Adipose Tissue Volume in HIV-Infected Men and Relationships to Body Composition and Metabolic Parameters

    PubMed Central

    Lo, Janet; Abbara, Suhny; Rocha-Filho, Jose A.; Shturman, Leon; Wei, Jeffrey; Grinspoon, Steven K.

    2011-01-01

    Summary Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV than control subjects (p=0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (VAT)(ρ = 0.76, p<0.0001), fasting glucose (ρ = 0.41, p=0.001) and insulin (ρ = 0.44, p=0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, VAT, and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients. PMID:20588167

  11. 1. Historic American Buildings Survey, Martin Linsey, Photographer October 2, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Martin Linsey, Photographer October 2, 1965 NORTH (FRONT) ELEVATION. - Trinity Episcopal Church, Euclid Avenue & East Twenty-Second Street, Cleveland, Cuyahoga County, OH

  12. Solar Energy

    ERIC Educational Resources Information Center

    Building Design and Construction, 1977

    1977-01-01

    Describes 21 completed projects now using solar energy for heating, cooling, or electricity. Included are elementary schools in Atlanta and San Diego, a technical school in Detroit, and Trinity University in San Antonio, Texas. (MLF)

  13. Short Report: Lack of Evidence of Hepatitis C and HIV Co-Infection among Men Who Have Sex with Men in Peru

    PubMed Central

    Lama, Javier R.; Lucchetti, Aldo; Cabezas, Cesar; Suarez-Ognio, Luis; Sanchez, Jorge

    2012-01-01

    Hepatitis C virus (HCV) infection occurs among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) because of shared routes of transmission. To assess the association between HCV and HIV infection among MSM in Peru, we conducted a matched case-control study (162 HIV-positive cases and 324 HIV-negative controls) among participants of an HIV sentinel surveillance survey in six urban cities. The HCV infection was initially screened using anti-HCV ELISA and immunoblot assay, and thereafter confirmed by the HCV RNA qualitative assay. Among cases, no confirmed HCV infection was found while among controls, only two confirmed HCV infections were reported (0.62%). This matched case-control reports a very low probability of association between HCV and HIV co-infection and suggests a very low prevalence of HCV infection among MSM in Peru. PMID:19556587

  14. A cross-site intervention in Chinese rural migrants enhances HIV/AIDS knowledge, attitude and behavior.

    PubMed

    Li, Ning; Li, Xiaomei; Wang, Xueliang; Shao, Jin; Dou, Juanhua

    2014-04-23

    With the influx of rural migrants into urban areas, the spread of HIV has increased significantly in Shaanxi Province (China). Migrant workers are at high risk of HIV infection due to social conditions and hardships (isolation, separation, marginalization, barriers to services, etc.). We explored the efficacy of a HIV/AIDS prevention and control program for rural migrants in Shaanxi Province, administered at both rural and urban sites. Guidance concerning HIV/AIDS prevention was given to the experimental group (266 migrants) for 1 year by the center of disease control, community health agencies and family planning department. The intervention was conducted according to the HIV/AIDS Prevention Management Manual for Rural Migrants. A control group of migrants only received general population intervention. The impact of the intervention was evaluated by administering HIV/AIDS knowledge, attitudes and sexual behavior (KAB) questionnaires after 6 and 12 months. In the experimental group; 6 months of intervention achieved improvements in HIV/AIDS related knowledge. After 12 months; HIV/AIDS-related knowledge reached near maximal scores. Attitude and most behaviors scores were significantly improved. Moreover; the experimental group showed significant differences in HIV-AIDS knowledge; attitude and most behavior compared with the control group. The systematic long-term cross-site HIV/AIDS prevention in both rural and urban areas is a highly effective method to improve HIV/AIDS KAB among rural migrants.

  15. Hearing Function in Patients Living with HIV/AIDS

    PubMed Central

    Luque, Amneris E.; Orlando, Mark S.; Leong, U-Cheng; Allen, Paul D.; Guido, Joseph J.; Yang, Hongmei; Wu, Hulin

    2014-01-01

    Background During the earlier years of the HIV/AIDS epidemic, initial reports described sensorineural hearing loss in up to 49% of individuals with HIV/AIDS. During those years, patients commonly progressed to advanced stages of HIV disease, and frequently had neurological complications. However, the abnormalities on pure-tone audiometry and brainstem evoked responses outlined in small studies were not always consistently correlated with advanced stages of HIV/AIDS. Moreover, these studies could not exclude the confounding effect of concurrent opportunistic infections and syphilis. Additional reports also have indicated that some antiretroviral (ARV) medications may be ototoxic, thus it has been difficult to make conclusions regarding the cause of changes in hearing function in HIV-infected patients. More recently, accelerated aging has been suggested as a potential explanation for the disproportionate increase in complications of aging described in many HIV-infected patients, hence accelerated aging associated hearing loss may also be playing a role in these patients. Methods We conducted a large cross-sectional analysis of hearing function in over 300 patients with HIV-1 infection and in 137 HIV-uninfected controls. HIV-infected participants and HIV-uninfected controls underwent a two-hour battery of hearing tests including the Hearing Handicap Inventory, standard audiometric pure-tone air and bone conduction testing, tympanometric testing and speech reception and discrimination testing. Results Three-way ANOVA and logistic regression analysis of 278 eligible HIV-infected subjects stratified by disease stage in early HIV disease (n= 127) and late HIV disease (n=148) and 120 eligible HIV-uninfected controls revealed no statistical significant differences among the three study groups in either overall 4-PTA or hearing loss prevalence in either ear. Three-way ANOVA showed significant differences in word recognition scores (WRS) in the right ear among groups; a significant group effect on tympanogram static admittance in both ears, and a significant group effect on tympanic gradient in the right ear. There was significantly larger admittance and gradient in controls as compared to the HIV-infected group at late stage of disease. Hearing loss in the HIV-infected groups was associated with increased age and was similar to that described in the literature for the general population. Three-way ANOVA analysis also indicated significantly greater pure tone thresholds (worse hearing) at low frequencies in HIV patients in the late stage of disease compared with HIV-uninfected controls. This difference was also found by semi-parametric mixed effects (SPME) models. Conclusions Despite reports of “premature” or “accelerated” aging in HIV-infected subjects, we found no evidence of hearing loss occurring at an earlier age in HIV-infected patients compared to HIV-uninfected controls. Similar to what is described in the general population; the probability of hearing loss increased with age in the HIV-infected subjects and was more common in patients over 60 years of age. Interestingly, HIV-infected subjects had worse hearing at lower frequencies and have significant differences in tympanometry compared to HIV-uninfected controls; these findings deserve further study. PMID:25127320

  16. Hearing function in patients living with HIV/AIDS.

    PubMed

    Luque, Amneris E; Orlando, Mark S; Leong, U-Cheng; Allen, Paul D; Guido, Joseph J; Yang, Hongmei; Wu, Hulin

    2014-01-01

    During the earlier years of the HIV/AIDS epidemic, initial reports described sensorineural hearing loss in up to 49% of individuals with HIV/AIDS. During those years, patients commonly progressed to advanced stages of HIV disease and frequently had neurological complications. However, the abnormalities on pure-tone audiometry and brainstem-evoked responses outlined in small studies were not always consistently correlated with advanced stages of HIV/AIDS. Moreover, these studies could not exclude the confounding effect of concurrent opportunistic infections and syphilis. Additional reports also have indicated that some antiretroviral medications may be ototoxic; thus, it has been difficult to make conclusions regarding the cause of changes in hearing function in HIV-infected patients. More recently, accelerated aging has been suggested as a potential explanation for the disproportionate increase in complications of aging described in many HIV-infected patients; hence, accelerated aging-associated hearing loss may also be playing a role in these patients. We conducted a large cross-sectional analysis of hearing function in over 300 patients with HIV-1 infection and in 137 HIV-uninfected controls. HIV-infected participants and HIV-uninfected controls underwent a 2-hr battery of hearing tests including the Hearing Handicap Inventory, standard audiometric pure-tone air and bone conduction testing, tympanometric testing, and speech reception and discrimination testing. Three-way analysis of variance (ANOVA) and logistic regression analysis of 278 eligible HIV-infected subjects stratified by disease stage in early HIV disease (n = 127) and late HIV disease (n = 148) and 120 eligible HIV-uninfected controls revealed no statistically significant differences among the three study groups in either overall 4-frequency pure-tone average (4-PTA) or hearing loss prevalence in either ear. Three-way ANOVA showed significant differences in word recognition scores in the right ear among groups, a significant group effect on tympanogram static admittance in both ears and a significant group effect on tympanic gradient in the right ear. There was significantly larger admittance and gradient in controls as compared to the HIV-infected group at late stage of disease. Hearing loss in the HIV-infected groups was associated with increased age and was similar to that described in the literature for the general population. Three-way ANOVA analysis also indicated significantly greater pure-tone thresholds (worse hearing) at low frequencies in HIV patients in the late stage of disease compared with HIV-uninfected controls. This difference was also found by semi-parametric mixed effects models. Despite reports of "premature" or "accelerated" aging in HIV-infected subjects, we found no evidence of hearing loss occurring at an earlier age in HIV-infected patients compared to HIV-uninfected controls. Similar to what is described in the general population, the probability of hearing loss increased with age in the HIV-infected subjects and was more common in patients over 60 years of age. Interestingly, HIV-infected subjects had worse hearing at lower frequencies and have significant differences in tympanometry compared to HIV-uninfected controls; these findings deserve further study.

  17. HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection.

    PubMed

    Laher, Faatima; Ranasinghe, Srinika; Porichis, Filippos; Mewalal, Nikoshia; Pretorius, Karyn; Ismail, Nasreen; Buus, Søren; Stryhn, Anette; Carrington, Mary; Walker, Bruce D; Ndung'u, Thumbi; Ndhlovu, Zaza M

    2017-04-01

    Immune control of viral infections is heavily dependent on helper CD4 + T cell function. However, the understanding of the contribution of HIV-specific CD4 + T cell responses to immune protection against HIV-1, particularly in clade C infection, remains incomplete. Recently, major histocompatibility complex (MHC) class II tetramers have emerged as a powerful tool for interrogating antigen-specific CD4 + T cells without relying on effector functions. Here, we defined the MHC class II alleles for immunodominant Gag CD4 + T cell epitopes in clade C virus infection, constructed MHC class II tetramers, and then used these to define the magnitude, function, and relation to the viral load of HIV-specific CD4 + T cell responses in a cohort of untreated HIV clade C-infected persons. We observed significantly higher frequencies of MHC class II tetramer-positive CD4 + T cells in HIV controllers than progressors ( P = 0.0001), and these expanded Gag-specific CD4 + T cells in HIV controllers showed higher levels of expression of the cytolytic proteins granzymes A and B. Importantly, targeting of the immunodominant Gag41 peptide in the context of HLA class II DRB1*1101 was associated with HIV control ( r = -0.5, P = 0.02). These data identify an association between HIV-specific CD4 + T cell targeting of immunodominant Gag epitopes and immune control, particularly the contribution of a single class II MHC-peptide complex to the immune response against HIV-1 infection. Furthermore, these results highlight the advantage of the use of class II tetramers in evaluating HIV-specific CD4 + T cell responses in natural infections. IMPORTANCE Increasing evidence suggests that virus-specific CD4 + T cells contribute to the immune-mediated control of clade B HIV-1 infection, yet there remains a relative paucity of data regarding the role of HIV-specific CD4 + T cells in shaping adaptive immune responses in individuals infected with clade C, which is responsible for the majority of HIV infections worldwide. Understanding the contribution of HIV-specific CD4 + T cell responses in clade C infection is particularly important for developing vaccines that would be efficacious in sub-Saharan Africa, where clade C infection is dominant. Here, we employed MHC class II tetramers designed to immunodominant Gag epitopes and used them to characterize CD4 + T cell responses in HIV-1 clade C infection. Our results demonstrate an association between the frequency of HIV-specific CD4 + T cell responses targeting an immunodominant DRB1*11-Gag41 complex and HIV control, highlighting the important contribution of a single class II MHC-peptide complex to the immune response against HIV-1 infections. Copyright © 2017 American Society for Microbiology.

  18. Regulatory T-cell activity but not conventional HIV-specific T-cell responses are associated with protection from HIV-1 infection

    PubMed Central

    Pattacini, Laura; Baeten, Jared M.; Thomas, Katherine K.; Fluharty, Tayler R.; Murnane, Pamela M.; Donnell, Deborah; Bukusi, Elizabeth; Ronald, Allan; Mugo, Nelly; Lingappa, Jairam R.; Celum, Connie; McElrath, M. Juliana; Lund, Jennifer M.

    2015-01-01

    Objective Two distinct hypotheses have been proposed for T-cell involvement in protection from HIV-1 acquisition. First, HIV-1-specific memory T-cell responses generated upon HIV-1 exposure could mount an efficient response to HIV-1 and inhibit the establishment of an infection. Second, a lower level of immune activation could reduce the numbers of activated, HIV-1-susceptible CD4+ T-cells, thereby diminishing the likelihood of infection. Methods To test these hypotheses, we conducted a prospective study among high-risk heterosexual men and women, and tested peripheral blood samples from individuals who subsequently acquired HIV-1 during follow-up (cases) and from a subset of those who remained HIV-1 uninfected (controls). Results We found no difference in HIV-1-specific immune responses between cases and controls, but Treg frequency was higher in controls as compared to cases and was negatively associated with frequency of effector memory CD4+ T-cells. Conclusions Our findings support the hypothesis that low immune activation assists in protection from HIV-1 infection. PMID:26656786

  19. Programmatic cost evaluation of nontargeted opt-out rapid HIV screening in the emergency department.

    PubMed

    Haukoos, Jason S; Campbell, Jonathan D; Conroy, Amy A; Hopkins, Emily; Bucossi, Meggan M; Sasson, Comilla; Al-Tayyib, Alia A; Thrun, Mark W

    2013-01-01

    The Centers for Disease Control and Prevention recommends nontargeted opt-out HIV screening in healthcare settings. Cost effectiveness is critical when considering potential screening methods. Our goal was to compare programmatic costs of nontargeted opt-out rapid HIV screening with physician-directed diagnostic rapid HIV testing in an urban emergency department (ED) as part of the Denver ED HIV Opt-Out Trial. This was a prospective cohort study nested in a larger quasi-experiment. Over 16 months, nontargeted rapid HIV screening (intervention) and diagnostic rapid HIV testing (control) were alternated in 4-month time blocks. During the intervention phase, patients were offered HIV testing using an opt-out approach during registration; during the control phase, physicians used a diagnostic approach to offer HIV testing to patients. Each method was fully integrated into ED operations. Direct program costs were determined using the perspective of the ED. Time-motion methodology was used to estimate personnel activity costs. Costs per patient newly-diagnosed with HIV infection by intervention phase, and incremental cost effectiveness ratios were calculated. During the intervention phase, 28,043 eligible patients were included, 6,933 (25%) completed testing, and 15 (0.2%, 95% CI: 0.1%-0.4%) were newly-diagnosed with HIV infection. During the control phase, 29,925 eligible patients were included, 243 (0.8%) completed testing, and 4 (1.7%, 95% CI: 0.4%-4.2%) were newly-diagnosed with HIV infection. Total annualized costs for nontargeted screening were $148,997, whereas total annualized costs for diagnostic HIV testing were $31,355. The average costs per HIV diagnosis were $9,932 and $7,839, respectively. Nontargeted HIV screening identified 11 more HIV infections at an incremental cost of $10,693 per additional infection. Compared to diagnostic testing, nontargeted HIV screening was more costly but identified more HIV infections. More effective and less costly testing strategies may be required to improve the identification of patients with undiagnosed HIV infection in the ED.

  20. Optimal control of HIV/AIDS dynamic: Education and treatment

    NASA Astrophysics Data System (ADS)

    Sule, Amiru; Abdullah, Farah Aini

    2014-07-01

    A mathematical model which describes the transmission dynamics of HIV/AIDS is developed. The optimal control representing education and treatment for this model is explored. The existence of optimal Control is established analytically by the use of optimal control theory. Numerical simulations suggest that education and treatment for the infected has a positive impact on HIV/AIDS control.

  1. The role of HIV infection in the etiology and epidemiology of diarrheal disease among children aged 0-59 months in Manhiça district, Rural Mozambique.

    PubMed

    Acácio, Sozinho; Nhampossa, Tacilta; Quintó, Llorenç; Vubil, Delfino; Sacoor, Charfudin; Kotloff, Karen; Farag, Tamer; Dilruba, Nasrin; Macete, Eusebio; Levine, Myron M; Alonso, Pedro; Mandomando, Inácio; Bassat, Quique

    2018-05-28

    Diarrhea is an important health problem among HIV-infected patients. This study evaluates the role of HIV on the epidemiology, etiology and severity of diarrheal disease among children. The Global Enteric Multicenter Study enrolled children with moderate-to-severe (MSD) and less severe (LSD) diarrhea between December 2007 and November 2012. One to three controls for MSD cases and one per LSD case were enrolled and matched by age, sex and neighborhood. All children were tested for HIV. Clinical, anthropometric data and stools were collected. A follow-up was performed at 60 days. 214 MSD cases and 418 controls, together with 349 LSD cases and 214 controls were tested. HIV prevalence among MSD cases was 25% (4% for matched controls) and 6% among LSD cases (6% among matched controls). HIV-infected children were more likely to have MSD (OR=5.6, p< 0.0001). Mortality rates were higher among HIV-infected children compared with uninfected (34 vs. 5 per 1000 children-weeks at risk; p=0.0039). Cryptosporidium, Giardia, EAEC (aatA only) were more prevalent among HIV-infected MSD-cases than uninfected ones. HIV is an important risk factor for MSD. The high mortality rate implies that children with MSD should be screened for HIV and managed accordingly. Copyright © 2018. Published by Elsevier Ltd.

  2. Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo

    PubMed Central

    Graf, Erin H.; Pace, Matthew J.; Peterson, Bennett A.; Lynch, Lindsay J.; Chukwulebe, Steve B.; Mexas, Angela M.; Shaheen, Farida; Martin, Jeffrey N.; Deeks, Steven G.; Connors, Mark; Migueles, Stephen A.; O’Doherty, Una

    2013-01-01

    Resting CD4+ T cells infected with HIV persist in the presence of suppressive anti-viral therapy (ART) and are barriers to a cure. One potential curative approach, therapeutic vaccination, is fueled by recognition of the ability of a subset of elite controllers (EC) to control virus without therapy due to robust anti-HIV immune responses. Controllers have low levels of integrated HIV DNA and low levels of replication competent virus, suggesting a small reservoir. As our recent data indicates some reservoir cells can produce HIV proteins (termed GPR cells for Gag-positive reservoir cells), we hypothesized that a fraction of HIV-expressing resting CD4+ T cells could be efficiently targeted and cleared in individuals who control HIV via anti-HIV cytotoxic T lymphocytes (CTL). To test this we examined if superinfected resting CD4+ T cells from EC express HIV Gag without producing infectious virus and the susceptibility of these cells to CTL. We found that resting CD4+ T cells expressed HIV Gag and were cleared by autologous CD8+ T cells from EC. Importantly, we found the extent of CTL clearance in our in vitro assay correlates with in vivo reservoir size and that a population of Gag expressing resting CD4+ T cells exists in vivo in patients well controlled on therapy. PMID:23951263

  3. Disruption of Emotion and Conflict Processing in HIV Infection with and without Alcoholism Comorbidity

    PubMed Central

    Schulte, Tilman; Müller-Oehring, Eva M.; Sullivan, Edith V.; Pfefferbaum, Adolf

    2012-01-01

    Alcoholism and HIV-1 infection each affect components of selective attention and cognitive control that may contribute to deficits in emotion processing based on closely interacting fronto-parietal attention and frontal-subcortical emotion systems. Here, we investigated whether patients with alcoholism, HIV-1 infection, or both diseases have greater difficulty than healthy controls in resolving conflict from emotional words with different valences. Accordingly, patients with alcoholism (ALC, n = 20), HIV-1 infection (HIV, n = 20), ALC + HIV comorbidity (n = 22), and controls (CTL, n = 16) performed an emotional Stroop Match-to-Sample task, which assessed the contribution of emotion (happy, angry) to cognitive control (Stroop conflict processing). ALC + HIV showed greater Stroop effects than HIV, ALC, or CTL for negative (ANGRY) but not for positive (HAPPY) words, and also when the cue color did not match the Stroop stimulus color; the comorbid group performed similarly to the others when cue and word colors matched. Furthermore, emotionally salient face cues prolonged color-matching responses in all groups. HIV alone, compared with the other three groups, showed disproportionately slowed color-matching time when trials featured angry faces. The enhanced Stroop effects prominent in ALC + HIV suggest difficulty in exercising attentional top-down control on processes that consume attentional capacity, especially when cognitive effort is required to ignore negative emotions. PMID:21418720

  4. HLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers

    PubMed Central

    Dominguez-Molina, Beatriz; Tarancon-Diez, Laura; Hua, Stephane; Abad-Molina, Cristina; Rodriguez-Gallego, Esther; Machmach, Kawthar; Vidal, Francesc; Tural, Cristina; Moreno, Santiago; Goñi, María José; Ramírez de Arellano, Elena; del Val, Margarita; Gonzalez-Escribano, María Francisca; Del Romero, Jorge; Rodriguez, Carmen; Capa, Laura; Viciana, Pompeyo; Alcamí, José; Yu, Xu G.; Walker, Bruce D.; Leal, Manuel; Lichterfeld, Mathias

    2017-01-01

    Abstract Background. Human immunodeficiency virus type 1 (HIV-1) controllers maintain HIV-1 viremia at low levels (normally <2000 HIV-RNA copies/mL) without antiretroviral treatment. However, some HIV-1 controllers have evidence of immunologic progression with marked CD4+ T-cell decline. We investigated host genetic factors associated with protection against CD4+ T-cell loss in HIV-1 controllers. Methods. We analyzed the association of interferon-lambda 4 (IFNL4)–related polymorphisms and human leukocyte antigen (HLA)-B haplotypes within long-term nonprogressor HIV-1 controllers (LTNP-Cs; defined by maintaining CD4+ T-cells counts >500 cells/mm3 for more than 7 years after HIV-1 diagnosis) vs non-LTNP-Cs who developed CD4+ T-cell counts <500 cells/mm3. Both a Spanish study cohort (n = 140) and an international validation cohort (n = 914) were examined. Additionally, in a subgroup of individuals, HIV-1–specific T-cell responses and soluble cytokines were analyzed. Results. HLA-B*57 was independently associated with the LTNP-C phenotype (odds ratio [OR], 3.056 [1.029–9.069]; P = .044 and OR, 1.924 [1.252–2.957]; P = .003) while IFNL4 genotypes represented independent factors for becoming non-LTNP-C (TT/TT, ss469415590; OR, 0.401 [0.171–0.942]; P = .036 or A/A, rs12980275; OR, 0.637 [0.434–0.934]; P = .021) in the Spanish and validation cohorts, respectively, after adjusting for sex, age at HIV-1 diagnosis, IFNL4-related polymorphisms, and different HLA-B haplotypes. LTNP-Cs showed lower plasma induced protein 10 (P = .019) and higher IFN-γ (P = .02) levels than the HIV-1 controllers with diminished CD4+ T-cell numbers. Moreover, LTNP-Cs exhibited higher quantities of interleukin (IL)2+CD57- and IFN-γ +CD57- HIV-1–specific CD8+ T cells (P = .002 and .041, respectively) than non-LTNP-Cs. Conclusions. We defined genetic markers able to segregate stable HIV-1 controllers from those who experience CD4+ T-cell decline. These findings allow for identification of HIV-1 controllers at risk for immunologic progression and provide avenues for personalized therapeutic interventions and precision medicine for optimizing clinical care of these individuals. PMID:27986689

  5. 4. Historic American Buildings Survey, Martin Linsey, Photographer October 2, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Martin Linsey, Photographer October 2, 1965 SOUTH ELEVATION OF CHAPEL. - Trinity Episcopal Church, Euclid Avenue & East Twenty-Second Street, Cleveland, Cuyahoga County, OH

  6. Two-year prospective study of major depressive disorder in HIV-infected men.

    PubMed

    Atkinson, J Hampton; Heaton, Robert K; Patterson, Thomas L; Wolfson, Tanya; Deutsch, Reena; Brown, Stephen J; Summers, J; Sciolla, A; Gutierrez, R; Ellis, Ronald J; Abramson, Ian; Hesselink, John R; McCutchan, J Allen; Grant, Igor

    2008-06-01

    The risks and factors contributing to major depressive episodes in HIV infection remain unclear. This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N=297) and uninfected (HIV-) risk-group controls (N=90). By design participants at entry were without current major depression, substance dependence or major anxiety disorder. Standardized neuromedical, neuropsychological, neuroimaging, life events, and psychiatric assessments (Structured Clinical Interview for DSM III-R) were conducted semi-annually for those with AIDS, and annually for all others. Lifetime prevalence of major depression or other psychiatric disorder did not differ at baseline between HIV+ men and controls. On a two-year follow-up those with symptomatic HIV disease were significantly more likely to experience a major depressive episode than were asymptomatic HIV+ individuals and HIV-controls (p<0.05). Episodes were as likely to be first onset as recurrent depression. After baseline disease stage and medical variables associated with HIV infection were controlled, a lifetime history of major depression, or of lifetime psychiatric comorbidity (two or more psychiatric disorders), predicted subsequent major depressive episode (p<0.05). Neither HIV disease progression during follow-up, nor the baseline presence of neurocognitive impairment, clinical brain imaging abnormality, or marked life adversity predicted a later major depressive episode. Research cohort of men examined before era of widespread use of advanced anti-HIV therapies. Symptomatic HIV disease, but not HIV infection itself, increases intermediate-term risk of major depression. Prior psychiatric history most strongly predicted future vulnerability.

  7. Evaluation of the Diagnostic Accuracy of CareStart G6PD Deficiency Rapid Diagnostic Test (RDT) in a Malaria Endemic Area in Ghana, Africa

    PubMed Central

    Adu-Gyasi, Dennis; Asante, Kwaku Poku; Newton, Sam; Dosoo, David; Amoako, Sabastina; Adjei, George; Amoako, Nicholas; Ankrah, Love; Tchum, Samuel Kofi; Mahama, Emmanuel; Agyemang, Veronica; Kayan, Kingsley; Owusu-Agyei, Seth

    2015-01-01

    Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most widespread enzyme defect that can result in red cell breakdown under oxidative stress when exposed to certain medicines including antimalarials. We evaluated the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) as a point-of-care tool for screening G6PD deficiency. Methods A cross-sectional study was conducted among 206 randomly selected and consented participants from a group with known G6PD deficiency status between February 2013 and June 2013. A maximum of 1.6ml of capillary blood samples were used for G6PD deficiency screening using CareStart G6PD RDT and Trinity qualitative with Trinity quantitative methods as the “gold standard”. Samples were also screened for the presence of malaria parasites. Data entry and analysis were done using Microsoft Access 2010 and Stata Software version 12. Kintampo Health Research Centre Institutional Ethics Committee granted ethical approval. Results The sensitivity (SE) and specificity (SP) of CareStart G6PD deficiency RDT was 100% and 72.1% compared to Trinity quantitative method respectively and was 98.9% and 96.2% compared to Trinity qualitative method. Malaria infection status had no significant (P=0.199) change on the performance of the G6PD RDT test kit compared to the “gold standard”. Conclusions The outcome of this study suggests that the diagnostic performance of the CareStart G6PD deficiency RDT kit was high and it is acceptable at determining the G6PD deficiency status in a high malaria endemic area in Ghana. The RDT kit presents as an attractive tool for point-of-care G6PD deficiency for rapid testing in areas with high temperatures and less expertise. The CareStart G6PD deficiency RDT kit could be used to screen malaria patients before administration of the fixed dose primaquine with artemisinin-based combination therapy. PMID:25885097

  8. Sedimentologic and Geometric Characterization of Turbidites of Brazos-Trinity Basin IV in the Gulf of Mexico: Preliminary Results of IODP Expedition 308

    NASA Astrophysics Data System (ADS)

    Gutierrez-Pastor, J.; Pirmez, C.; Flemings, P. B.; Behrmann, J. H.; John, C. M.

    2005-12-01

    Brazos Trinity Basin IV is located about 200 km offshore Texas, and belongs to a linked system of four intra slope mini basins. Basin IV provides a type section to characterize turbidites in salt withdrawal mini-basins of the Gulf of Mexico. IODP Expedition 308 has cored and logged complete pre-fan and fan sequences that are clearly distinguished with high-resolution seismic profiles at Brazos Trinity Basin IV at Sites U1319, U1320 and U1321. Seismically imaged pre-fan and fan units also can be distinguished and correlated with the sedimentological and logging data. Turbidite facies display distinct properties in terms of grain size, bed thickness, color, organic matter content, vertical organization of beds and lateral distribution in all the units of the fan through the basin. The pre-fan sequence is composed of terrigenous laminated clay with color banding and it is interpreted to result from deposition from fluvial plumes and/or muddy turbidity currents overspilling from basins upstream of Basin IV. The lower fan is characterized by laminated and bioturbated muds with thin beds of silt and sand, and represent the initial infill of the basin by mostly muddy turbidity currents, although an exceptionally sand-rich unit occurs at the base of the lower fan. The middle and upper fan represent the main pulses of turbidity current influx into Basin IV, and contain fine to medium sand turbidite beds organized in packets ranging in thickness from 5 to 25 m. The middle fan displays an overall upward increase in sand content at Site U1320, suggesting increased flow by-pass from the updip basins through time. Key examples of turbidites from each fan unit are analysed in detail to infer the depositional processes and infilling history of Brazos-Trinity Basin IV. The study of turbidites in a calibrated basin such as Basin IV provides ground truth for the sedimentological processes and resultant seismic facies, which can be used to interpret the infill history of other intraslope basins with similar seismic facies in the Gulf of Mexico where well calibration is not available.

  9. Pore Water Chemistry as Sensitive Indicators for Fluid Flow in Brazos-Trinity Basin #4 and Ursa Basin, Northeast Gulf of Mexico (IODP Expedition 308)

    NASA Astrophysics Data System (ADS)

    Jiang, S.; Gilhooly, W.; Takano, Y.; Flemings, P.; Behrmann, J.; John, C.

    2005-12-01

    Rapid sediment loading drives overpressure in marine sedimentary basins around the world. During IODP Expedition 308, two basins (Brazos-Trinity Basin #4 and Ursa Basin) with large different sedimentary loading of turbidite and hemipelagic sediments in the northeast Gulf of Mexico, were investigated to characterize in-situ spatial variations in temperature, pressure, and rock and fluid physical properties and chemistry. Pore water chemical compositions including alkalinity, salinity, pH, anions (Cl, SO4, PO4, H4SiO4), cations (Na, K, Ca, Mg), trace metals (Li, B, Sr, Ba, Fe, Mn), were analyzed in four drill holes at sites U1319, U1320, U1322, and U1324, in the Brazos-Trinity Basin #4 and Ursa Basin. At all sites, pore water chemistry shows great variability at shallow depths with maximam or miminum values corresponding well to seismic reflectors and lithostratigraphic units. The sulfate profile shows a dramatic decrease in SO4 content with a sulfate-methane interface (SMI) of 15 mbsf at Site 1319 and 22 mbsf at Site 1320 in the Brazos-Trinity Basin #4 Basin. In contrast, the sulfate- methane interfaces (SMI) are much deeper in Ursa Basin, i.e., 74 mbsf at Site 1322, and 94 mbsf at Site 2324. The deep SMI in Ursa Basin suggest relatively slow anaerobic degradation of organic matter considering the location of drilling site though we do not determine sulfate reducing rate with organic matter or methane as substrate at this leg. The downhole consumption of sulfate coincides with a concomitant increase in alkalinity and a decrease of Mn, Ca, Mg, Sr, and Li. Furthermore, initial pore water chemistry results appear to be influence by hydrogeologic fluid flow in both basins. Coincidence between pore water profile concentration maxima and parallel seismic reflectors may suggest that these seismic surfaces occur along specific stratigraphic units, which serve as channels for lateral fluid flow. Overall, the downhole variations in interstitial water chemistry may reflect a combination of processes, including anaerobic degradation of organic matter, diagenetic carbonate precipitation/dissolution, and fluid flow pathways.

  10. 76 FR 367 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Minority HIV...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ..., Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Minority HIV/AIDS Research... Researchers To Conduct HIV/AIDS Epidemiologic and Prevention Research, Funding Opportunity Announcement (FOA... HIV/AIDS Research Initiative (MARI) to Build Capacity in Black and Hispanic Communities and Among...

  11. Age at Virologic Control Influences Peripheral Blood HIV Reservoir Size and Serostatus in Perinatally-Infected Adolescents

    PubMed Central

    Persaud, Deborah; Patel, Kunjal; Karalius, Brad; Rainwater-Lovett, Kaitlin; Ziemniak, Carrie; Ellis, Angela; Chen, Ya Hui; Richman, Douglas; Siberry, George K.; Van Dyke, Russell B.; Burchett, Sandra; Seage, George R.; Luzuriaga, Katherine

    2014-01-01

    Importance Combination antiretroviral therapy (cART) initiated within several weeks of HIV infection in adults limits proviral reservoirs that preclude HIV cure. Biomarkers of restricted proviral reservoirs may aid in the monitoring of HIV remission or cure. Objectives To quantify peripheral blood proviral reservoir size in perinatally HIV-infected adolescents and to identify correlates of limited proviral reservoirs. Design, Setting, and Participants A cross-sectional study including 144 perinatally HIV-infected (PHIV+) youth (median age: 14.3 years), enrolled in the US-based Pediatric HIV/AIDS Cohort Study, on durable (median: 10.2 years) cART, stratified by age at virologic control. Main Outcome and Measures The primary endpoint was peripheral blood mononuclear cell (PBMC) proviral load following virologic control at different ages. Correlations between proviral load and markers of active HIV production (HIV-specific antibodies, 2-long terminal repeat (2-LTR) circles), and markers of immune activation and inflammation were also assessed. Results Proviral reservoir size was markedly reduced in the PHIV+ youth who achieved virologic control by age 1 year (4.2 [interquartile range, 2.6-8 6] copies per 1 million PBMCs) compared to those who achieved virologic control between 1-5 years of age (19.4 [interquartile range, 5.5-99.8] copies per 1 million PBMCs) or after age 5 years (−(70.7 [interquartile range, 23.2-209.4] copies per 1 million PBMCs; P < .00l). A proviral burden <10 copies/million PBMCs was measured in 11 (79%), 20 (40%), and 13 (18%) participants with virologic control at ages <1 year, 1-5 years, and >5 years, respectively (p<0.001). Lower proviral load was associated with undetectable 2-LTR circles (p<0.001) and HIV negative or indeterminate serostatus (p<0.001), but not with concentrations of soluble immune activation markers CD14 and CD163. Conclusions and Relevance Early effective cART along with prolonged virologic suppression after perinatal HIV infection leads to negligible peripheral blood proviral reservoirs in adolescence and is associated with negative or indeterminate HIV serostatus. These findings highlight the long-term effect of early effective control of HIV replication on biomarkers of HIV persistence in perinatal infection and the utility of HIV serostatus as a biomarker for small proviral reservoir size, though not necessarily of cure. PMID:25286283

  12. Non-disclosure of HIV-positive status to a partner and mother-to-child transmission of HIV: Evidence from a case–control study conducted in a rural county in Kenya

    PubMed Central

    2017-01-01

    Background Many factors contribute to an enhanced risk of infant HIV acquisition, two of which may include failure of a mother to disclose her HIV-positive status to her partner and exclusion of male partners in preventing mother-to-child transmission of HIV (PMTCT) interventions. To justify why HIV programmes need to integrate male partner involvement and partner disclosure, we need to establish an association between the two factors and infant HIV acquisition. Objective To determine whether failure to disclose an HIV-positive status to a male partner is associated with increased risk of infant HIV acquisition, and whether part of the association is explained by exclusion of male partner in PMTCT programmes. Methods Using a case–control study design, we identified a total of 180 mother–baby pairs with HIV-exposed infants. Thirty-six pairs with HIV-positive babies (cases) were compared to 144 pairs with HIV-negative babies (controls) on whether the mothers had disclosed their HIV status to their partner in order to determine whether a disclosure or lack of it contributed to increased risk of mother-to-child transmission of HIV (MTCT). Each case pair was matched to four control pairs from the same facility. Results Overall, 16.7% of mothers had not disclosed their HIV status to their partners, the proportion being significantly more among cases (52.8% vs. 7.6%, p < 0.001). Non-disclosure was significantly associated with infant HIV acquisition (aOR 9.8 (3.0–26.3); p < 0.001) and male partner involvement partially mediated the effect of non-disclosure on infant HIV acquisition (indirect coefficient = 0.17, p < 0.005). Conclusions Failure of an HIV-positive woman to disclose her status to her male partner and exclusion of male partners in PMTCT programmes are two social factors that may curtail success of interventions towards the goal of eliminating MTCT. PMID:29568627

  13. A case-control study of syphilis among men who have sex with men in New York City: association With HIV infection.

    PubMed

    Paz-Bailey, Gabriela; Meyers, Andrea; Blank, Susan; Brown, James; Rubin, Steve; Braxton, Jim; Zaidi, Akbar; Schafzin, Josh; Weigl, Susan; Markowitz, Laurie E

    2004-10-01

    The objective of this study was to determine factors associated with syphilis among men who report sex with other men in New York City. DESIGN, SETTING AND STUDY SUBJECTS: We conducted a case-control study among 88 men who reported sex with men in the previous year, 18 to 55 years old and diagnosed with primary or secondary syphilis during 2001; and 176 control subjects frequently matched by age and type of health provider. HIV prevalence among syphilis cases was 48% compared with 15% among control subjects (P <0.001). Variables associated with syphilis in a multivariate model were HIV infection (odds ratio [OR], 7.3; 95% confidence interval [CI], 3.5-15.4), income >$30,000 per year (OR, 2.7; CI, 1.4-5.2), and barebacking (OR, 2.6; CI, 1.4-4.8). The median time since HIV diagnosis for HIV-positive was 6 years for cases and 7 years for control subjects (P = 0.70). Among HIV-infected participants, syphilis cases were more likely than control subjects to report being on antiretroviral therapy (69% vs. 44%, P = 0.05) and to report having undetectable viral load (58% vs. 24%, P = 0.02). HIV infection was strongly associated with syphilis in this study. High-risk behavior reported by both cases and control subjects indicates the potential for increased HIV transmission.

  14. Risk of breast cancer with CXCR4-using HIV defined by V3 loop sequencing.

    PubMed

    Goedert, James J; Swenson, Luke C; Napolitano, Laura A; Haddad, Mojgan; Anastos, Kathryn; Minkoff, Howard; Young, Mary; Levine, Alexandra; Adeyemi, Oluwatoyin; Seaberg, Eric C; Aouizerat, Bradley; Rabkin, Charles S; Harrigan, P Richard; Hessol, Nancy A

    2015-01-01

    Evaluate the risk of female breast cancer associated with HIV-CXCR4 (X4) tropism as determined by various genotypic measures. A breast cancer case-control study, with pairwise comparisons of tropism determination methods, was conducted. From the Women's Interagency HIV Study repository, one stored plasma specimen was selected from 25 HIV-infected cases near the breast cancer diagnosis date and 75 HIV-infected control women matched for age and calendar date. HIV-gp120 V3 sequences were derived by Sanger population sequencing (PS) and 454-pyro deep sequencing (DS). Sequencing-based HIV-X4 tropism was defined using the geno2pheno algorithm, with both high-stringency DS [false-positive rate (3.5) and 2% X4 cutoff], and lower stringency DS (false-positive rate, 5.75 and 15% X4 cutoff). Concordance of tropism results by PS, DS, and previously performed phenotyping was assessed with kappa (κ) statistics. Case-control comparisons used exact P values and conditional logistic regression. In 74 women (19 cases, 55 controls) with complete results, prevalence of HIV-X4 by PS was 5% in cases vs 29% in controls (P = 0.06; odds ratio, 0.14; confidence interval: 0.003 to 1.03). Smaller case-control prevalence differences were found with high-stringency DS (21% vs 36%, P = 0.32), lower stringency DS (16% vs 35%, P = 0.18), and phenotyping (11% vs 31%, P = 0.10). HIV-X4 tropism concordance was best between PS and lower stringency DS (93%, κ = 0.83). Other pairwise concordances were 82%-92% (κ = 0.56-0.81). Concordance was similar among cases and controls. HIV-X4 defined by population sequencing (PS) had good agreement with lower stringency DS and was significantly associated with lower odds of breast cancer.

  15. Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals.

    PubMed

    Godoi, Emmanuelle Tenório Albuquerque Madruga; Brandt, Carlos Teixeira; Lacerda, Heloisa Ramos; Godoi, Jocelene Tenório Albuquerque Madruga; Oliveira, Dinaldo Cavalcanti de; Costa, Gabriela Farias Araujo Sousa; Santos Junior, Gerson Gomes Dos; Leite, Kaliene Maria Estevão; Godoi, Juannicelle Tenório Albuquerque Madruga; Vasconcelos, Adriana Ferraz de

    2017-01-01

    The prevalence of atherosclerosis is higher in HIV-positive people, who also experience it earlier than the general population. To assess and compare the prevalence of atherosclerosis evaluated by the intima-media thickness of carotid and femoral arteries, and by the ankle-brachial pressure index (ABPI) in HIV patients treated or not treated with protease inhibitors (PIs) and controls. Eighty HIV+ subjects (40 using PIs and 40 not using PIs) and 65 controls were included in the study. Atherosclerosis was diagnosed by (carotid and femoral) ITM measurement and ABPI. Classical risk factors for atherosclerosis and HIV were compared between the groups by statistical tests. A p ≤ 0.05 was considered significant. An IMT > P75 or the presence of plaque was higher in the HIV+ than in the control group (37.5% vs 19%, p = 0.04). Comparative analysis showed a significant difference (p=0.014) in carotid IMT between HIV+ with PIs (0.71 ± 0.28 mm), without PIs 0.63 ± 0.11 mm and, and controls (0.59 ± 0.11 mm). There was no significant difference in femoral IMT between the groups or in ABPI between HIV+ subjects and controls. However, a significant difference (p=0.015) was found between HIV+ patients not treated with PIs (1.17 [1.08 - 1.23]), and controls 1.08 [1.07 - 1.17]). In HIV patients, atherosclerosis is more prevalent and seems to occur earlier with particular characteristics compared with HIV-negative subjects.

  16. HIV Infection Affects Streptococcus mutans Levels, but Not Genotypes

    PubMed Central

    Liu, G.; Saxena, D.; Chen, Z.; Norman, R.G.; Phelan, J.A.; Laverty, M.; Fisch, G.S.; Corby, P.M.; Abrams, W.; Malamud, D.; Li, Y.

    2012-01-01

    We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventional culture methods. The genotype of S. mutans was compared between 10 HIV-positive individuals before and after highly active antiretroviral therapy (HAART) and 10 non-HIV-infected control individuals. The results were analyzed against viral load, CD4+ and CD8+ T-cell counts, salivary flow rate, and caries status. We observed that S. mutans levels were higher in HIV-infected individuals than in the non-HIV-infected control individuals (p = 0.013). No significant differences in S. mutans genotypes were found between the two groups over the six-month study period, even after HAART. There was a bivariate linear relationship between S. mutans levels and CD8+ counts (r = 0.412; p = 0.007), but not between S. mutans levels and either CD4+ counts or viral load. Furthermore, compared with non-HIV-infected control individuals, HIV-infected individuals experienced lower salivary secretion (p = 0.009) and a positive trend toward more decayed tooth surfaces (p = 0.027). These findings suggest that HIV infection can have a significant effect on the level of S. mutans, but not genotypes. PMID:22821240

  17. HIV and child mental health: a case-control study in Rwanda.

    PubMed

    Betancourt, Theresa; Scorza, Pamela; Kanyanganzi, Frederick; Fawzi, Mary C Smith; Sezibera, Vincent; Cyamatare, Felix; Beardslee, William; Stulac, Sara; Bizimana, Justin I; Stevenson, Anne; Kayiteshonga, Yvonne

    2014-08-01

    The global HIV/AIDS response has advanced in addressing the health and well-being of HIV-positive children. Although attention has been paid to children orphaned by parental AIDS, children who live with HIV-positive caregivers have received less attention. This study compares mental health problems and risk and protective factors in HIV-positive, HIV-affected (due to caregiver HIV), and HIV-unaffected children in Rwanda. A case-control design assessed mental health, risk, and protective factors among 683 children aged 10 to 17 years at different levels of HIV exposure. A stratified random sampling strategy based on electronic medical records identified all known HIV-positive children in this age range in 2 districts in Rwanda. Lists of all same-age children in villages with an HIV-positive child were then collected and split by HIV status (HIV-positive, HIV-affected, and HIV-unaffected). One child was randomly sampled from the latter 2 groups to compare with each HIV-positive child per village. HIV-affected and HIV-positive children demonstrated higher levels of depression, anxiety, conduct problems, and functional impairment compared with HIV-unaffected children. HIV-affected children had significantly higher odds of depression (1.68: 95% confidence interval [CI] 1.15-2.44), anxiety (1.77: 95% CI 1.14-2.75), and conduct problems (1.59: 95% CI 1.04-2.45) compared with HIV-unaffected children, and rates of these mental health conditions were similar to HIV-positive children. These results remained significant after controlling for contextual variables, there were no significant differences on mental health outcomes groups, reflecting a potential explanatory role of factors such as daily hardships, caregiver depression, and HIV-related stigma [corrected]. The mental health of HIV-affected children requires policy and programmatic responses comparable to HIV-positive children. Copyright © 2014 by the American Academy of Pediatrics.

  18. Evaluation of bone mineral density in Iranian HIV/AIDS patients.

    PubMed

    Badie, Banafsheh Moradmand; Soori, Tahereh; Kheirandish, Parastoo; Izadyar, Saeed; SeyedAlinagh, SeyedAhmad; Foroughi, Maryam; Rostamian, Alireza; Mohraz, Minoo

    2011-01-01

    Bone disorders have emerged as a worrisome complication in HIV-infected patients in recent years. It is not clear that HIV infection itself or antiretroviral treatment or both are causes of bone loss. However, most studies have found a high prevalence of osteopenia and osteoporosis in HIV/AIDS patients. The objectives of this study were to determine the prevalence of osteopenia and osteoporosis in HIV-infected patients either untreated or receiving Highly Active Antiretroviral Therapy as compared with HIV negative persons. We also assessed the factors associated with these conditions. Bone Mineral Density was assessed by Dual Energy X-Ray Absorptiometry scans at the hip and lumbar spine in 36 AIDS patients receiving antiretroviral therapy and 44 HIV infected patients not receiving antiretroviral therapy (naïve patients) and 40 HIV negative individuals as control. Factors that affect BMD were also determined. Prevalence of osteopenia or osteoporosis in different regions was significantly higher in HIV/AIDS patients compared with HIV negative subjects (77.3% in HIV positive naïve patients, 86.1% in HAART-treated patients and 60% in the control group, P=0.002). Mean serum alkaline phosphatase was higher in HIV/AIDS patients than the control group (P=0.003). Osteopenia and osteoporosis in HIV-infected patients were associated with duration of HIV infection (P<0.0001) and antiretroviral treatment (P=0.012). Prevalence of osteopenia and osteoporosis in HIV/AIDS patients was higher than HIV negative individuals. Osteopenia and osteoporosis in HIV/AIDS patients was associated with duration of HIV infection and antiretroviral treatment.

  19. Engineering HIV-Specific Immunity with Chimeric Antigen Receptors.

    PubMed

    Kitchen, Scott G; Zack, Jerome A

    2016-12-01

    HIV remains a highly important public health and clinical issue despite many recent advances in attempting to develop a cure, which has remained elusive for most people infected with HIV. HIV disease can be controlled with pharmacologic therapies; however, these treatments are expensive, may have severe side effects, and are not curative. Consequently, an improved means to control or eliminate HIV replication is needed. Cytotoxic T lymphocytes (CTLs) play a critical role in controlling viral replication and are an important part in the ability of the immune response to eradicate most viral infections. There are considerable efforts to enhance CTL responses in HIV-infected individuals in hopes of providing the immune response with armaments to more effectively control viral replication. In this review, we discuss some of these efforts and focus on the development of a gene therapy-based approach to engineer hematopoietic stem cells with an HIV-1-specific chimeric antigen receptor, which seeks to provide an inexhaustible source of HIV-1-specific immune cells that are MHC unrestricted and superior to natural antiviral T cell responses. These efforts provide the basis for further development of T cell functional enhancement to target and treat chronic HIV infection in hopes of eradicating the virus from the body.

  20. Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

    PubMed Central

    Richardson, Max W.; Ellebrecht, Christoph T.; Glover, Joshua A.; Secreto, Anthony J.; Kulikovskaya, Irina; Yi, Yanjie; Wang, Jianbin; Dufendach, Keith A.; Holmes, Michael C.; Collman, Ronald G.

    2017-01-01

    HIV is adept at avoiding naturally generated T cell responses; therefore, there is a need to develop HIV-specific T cells with greater potency for use in HIV cure strategies. Starting with a CD4-based chimeric antigen receptor (CAR) that was previously used without toxicity in clinical trials, we optimized the vector backbone, promoter, HIV targeting moiety, and transmembrane and signaling domains to determine which components augmented the ability of T cells to control HIV replication. This re-engineered CAR was at least 50-fold more potent in vitro at controlling HIV replication than the original CD4 CAR, or a TCR-based approach, and substantially better than broadly neutralizing antibody-based CARs. A humanized mouse model of HIV infection demonstrated that T cells expressing optimized CARs were superior at expanding in response to antigen, protecting CD4 T cells from infection, and reducing viral loads compared to T cells expressing the original, clinical trial CAR. Moreover, in a humanized mouse model of HIV treatment, CD4 CAR T cells containing the 4-1BB costimulatory domain controlled HIV spread after ART removal better than analogous CAR T cells containing the CD28 costimulatory domain. Together, these data indicate that potent HIV-specific T cells can be generated using improved CAR design and that CAR T cells could be important components of an HIV cure strategy. PMID:29023549

  1. A Cross-Site Intervention in Chinese Rural Migrants Enhances HIV/AIDS Knowledge, Attitude and Behavior

    PubMed Central

    Li, Ning; Li, Xiaomei; Wang, Xueliang; Shao, Jin; Dou, Juanhua

    2014-01-01

    Background: With the influx of rural migrants into urban areas, the spread of HIV has increased significantly in Shaanxi Province (China). Migrant workers are at high risk of HIV infection due to social conditions and hardships (isolation, separation, marginalization, barriers to services, etc.). Objective: We explored the efficacy of a HIV/AIDS prevention and control program for rural migrants in Shaanxi Province, administered at both rural and urban sites. Methods: Guidance concerning HIV/AIDS prevention was given to the experimental group (266 migrants) for 1 year by the center of disease control, community health agencies and family planning department. The intervention was conducted according to the HIV/AIDS Prevention Management Manual for Rural Migrants. A control group of migrants only received general population intervention. The impact of the intervention was evaluated by administering HIV/AIDS knowledge, attitudes and sexual behavior (KAB) questionnaires after 6 and 12 months. Results: In the experimental group; 6 months of intervention achieved improvements in HIV/AIDS related knowledge. After 12 months; HIV/AIDS-related knowledge reached near maximal scores. Attitude and most behaviors scores were significantly improved. Moreover; the experimental group showed significant differences in HIV-AIDS knowledge; attitude and most behavior compared with the control group. Conclusions: The systematic long-term cross-site HIV/AIDS prevention in both rural and urban areas is a highly effective method to improve HIV/AIDS KAB among rural migrants. PMID:24762671

  2. 79. SITE INSTRUMENTATION: INTERIOR OF INSTRUMENTATION BUNKER AT 800 WEST, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    79. SITE INSTRUMENTATION: INTERIOR OF INSTRUMENTATION BUNKER AT 800 WEST, WITH WOODEN WORK BENCH - White Sands Missile Range, Trinity Site, Vicinity of Routes 13 & 20, White Sands, Dona Ana County, NM

  3. 2. Historic American Buildings Survey, Martin Linsey, Photographer October 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Martin Linsey, Photographer October 26, 1965 SOUTHWEST CORNER (22ND ST. SIDE). - Trinity Episcopal Church, Euclid Avenue & East Twenty-Second Street, Cleveland, Cuyahoga County, OH

  4. 7. Historic American Buildings Survey, Martin Linsey, Photographer March 23, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Martin Linsey, Photographer March 23, 1966 PHOTOCOPY OF ARCHITECT'S RENDERING FOR ROMANESQUE DESIGN. - Trinity Episcopal Church, Euclid Avenue & East Twenty-Second Street, Cleveland, Cuyahoga County, OH

  5. 8. Historic American Buildings Survey, Martin Linsey, Photographer March 23, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Martin Linsey, Photographer March 23, 1966 PHOTOCOPY OF ARCHITECT'S RENDERING FOR REVISED DESIGN. - Trinity Episcopal Church, Euclid Avenue & East Twenty-Second Street, Cleveland, Cuyahoga County, OH

  6. Elite control of HIV: is this the right model for a functional cure?

    PubMed

    Cockerham, Leslie R; Hatano, Hiroyu

    2015-02-01

    A cure for HIV is still greatly needed and has become a global research priority. A unique subset of HIV-infected individuals who spontaneously control HIV exists, and these are known as 'elite controllers'. They may represent a natural model for a 'functional cure' in which there is long term control of viral replication and remission from symptoms of HIV infection in the absence of antiretroviral therapy. However, controllers have evidence of ongoing inflammation, CD4(+) T cell depletion, and perhaps even inflammation-associated cardiovascular disease, suggesting that this natural long term virologic control may be coming at an immunologic and clinical cost. These individuals may continue to provide continued insights into mechanisms of host control; however, they may not represent the best model of a functional cure, if we believe that a cure should require a disease-free (and not just a treatment-free) state. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Detection of Unknown Crypts under the Floor in the Holy Trinity Church (Dominican Monastery) in Krakow, Poland

    NASA Astrophysics Data System (ADS)

    Strzępowicz, Anna; Łyskowski, Mikołaj; Ziętek, Jerzy; Tomecka-Suchoń, Sylwia

    2018-03-01

    The GPR surveying method belongs to non-invasive and quick geophysical methods, applied also in archaeological prospection. It allows for detecting archaeological artefacts buried under historical layers, and also those which can be found within buildings of historical value. Most commonly, just as in this particular case, it is used in churches, where other non-invasive localisation methods cannot be applied. In a majority of cases, surveys bring about highly positive results, enabling the site and size of a specific object to be indicated. A good example are the results obtained from the measurements carried out in the Basilica of Holy Trinity, belonging to the Dominican Monastery in Krakow. They allowed for confirming the location of the already existing crypts and for indicating so-far unidentified objects.

  8. Survey of the Urban Bell in the Belfry of St. Trinity Church in Krosno

    NASA Astrophysics Data System (ADS)

    Oleniacz, Grzegorz; Skrzypczak, Izabela; Ślęczka, Lucjan; Świętoń, Tomasz; Rymar, Marta

    2017-06-01

    Urban is one of the three bells in the belfry of St. Trinity Church in Krosno. It is the largest one, with diameter equal to 1,535 mm and it is commonly considered as one of the largest historical bells in Poland. The total mass of all the three bells is close to 4,200 kilograms, so the dynamic actions produced by swinging have a great effect on the supporting structure and on the tower. However, the exact weight of the biggest bell isn't known, and for safety reasons it should be estimated in order to verify the real dynamic forces affecting the structure. The paper describes the method of Urban bell's survey using terrestrial laser scanning and a total station as a task to estimate its weight by determining its volume.

  9. Trinity mysteries: university, elite schooling and sport in Ireland.

    PubMed

    Finn, Gerry P T

    2010-01-01

    The development of sport in Ireland was, contrary to some arguments, highly influenced by English examples and Anglo-Irish institutions. Trinity College and prestigious Irish schools did have an impact, as did the number of Irish students sent to England for public school or university education. Athleticism was evident in Ireland as it was in England. Although the development of soccer did follow a slightly different trajectory from other sports, as was also the case in both England and Scotland, this does not mean that it departed from this broad evolutionary model of Irish sport. Yet this was Ireland: and Ireland was different. As opposition to British rule intensified, forms of sporting participation took on more and more of a national symbolism. The outcome was the emergence of a very potent form of athleticism: an Irish athleticism for an Irish people.

  10. Sociodemographic differences among HIV-positive and HIV-negative recently pregnant women in Mexico City

    PubMed Central

    Aguilar-Zapata, Daniel; Piñeirúa-Menéndez, Alicia; Volkow-Fernández, Patricia; Rodríguez-Zulueta, Patricia; Ramos-Alamillo, Ubaldo; Cabrera-López, Teresita; Martin-Onraet, Alexandra

    2017-01-01

    Abstract National HIV preventive programs in Mexico focus on high-risk groups that do not consider women, apart from prenatal screening. Nonetheless, the epidemic in women is growing, and there is a need to better understand sociodemographic factors in women living with HIV (WLH). We performed a case–control study in Mexico City, including HIV+ and HIV− women with a recent pregnancy to compare their sociodemographic characteristics and describe the circumstances of diagnosis in HIV+ women, as well as prenatal screening frequency in both groups. Fifty cases and 102 controls were interviewed. HIV+ women were more frequently the only economic support of the family (20% vs 0%, P < .0001). Thirty-eight percent of cases had their first pregnancy at ≤18 years, versus 16% of controls (odds ratio 2.47, 95% confidence interval 1.07–5.72, P = .03); 16% of cases had lived in the street; 6% reported transactional sex, versus none of the controls (P < .0001). In the multivariate analysis, there was strong evidence of an association between HIV infection and age at the time of the interview, history of sexually transmitted diseases, substance abuse, history of violence, and civil status. Only 6% of controls were tested for HIV during prenatal follow-up. WLH in this study faced important social vulnerability. Targeting women living in these social contexts might increase early diagnosis and could tailor HIV prevention strategies. Prenatal coverage needs to be improved and should represent a national priority. PMID:28682879

  11. Sandstone detrital modes and basinal setting of the Trinity Peninsula Group, northern Graham Land, Antarctic Peninsula: A preliminary survey

    NASA Astrophysics Data System (ADS)

    Smellie, J. L.

    Sandstone detrital modes for a representative sample of the Trinity Peninsula Group in northern Graham Land are described and assessed. Whereas the volumetrically dominant quartz and feldspar were derived principally from erosion of a plutonic and high-rank metamorphic terrane, the lithic population was derived mainly from a volcanic cover. The data clearly indicate the presence of two major sandstone suites (petro-facies I and II) with distinctive and probably separate provenances. Further scope for subdivision is limited by the small sample set, but four petrofacies (Ia, Ib, IIa, and IIb) may be present, three of which correspond with previously described lithostratigraphical units (Legoupil, Hope Bay, and View Point formations). The sample distribution and detrital modes enable approximate geographical limits to be assigned to each petrofacies for the first time, although the nature of the boundaries (stratigraphical or structural) is unknown. Petrofacies II could have been derived from an active magmatic arc and deposited in a forearc basin (sensu lato) or series of basins at a major consuming margin. Petrofacies I is a much more quartzose suite, although otherwise petrographically very similar to petrofacies II. Its depositional setting is ambiguous on the basis of the data presently available, and deposition can only be said to have occurred at either an active or a passive continental margin. Finally, there is the possibility that strike-slip faulting has structurally shuffled the Trinity Peninsula Group, causing the pronounced age and compositional contrasts observed.

  12. Overpressure and consolidation near the seafloor of Brazos-Trinity Basin IV, northwest deepwater Gulf of Mexico

    NASA Astrophysics Data System (ADS)

    Schneider, Julia; Flemings, Peter B.; Dugan, Brandon; Long, Hui; Germaine, John T.

    2009-05-01

    Pore water overpressures (u*) within mudstones beneath Brazos-Trinity Basin IV (deepwater Gulf of Mexico, offshore Texas) are greater than 70% of the hydrostatic vertical effective stress (σ'vh) [λ* = 0.7 = (u*/σ'vh)]. These results are compatible with recent observations that suggest sedimentation rates in this region are rapid (6 mm/a). We compare the petrophysical properties and pore pressures within a 127-m-thick package of mudstone penetrated at two locations: Integrated Ocean Drilling Program (IODP) sites U1319 and U1320. Site U1319 is at the margin of Brazos-Trinity Basin IV, whereas Site U1320 lies at its center, beneath 180 m of turbidite fill. Experimentally derived preconsolidation stresses and an in situ pore pressure measurement record overpressure at Site U1319 and Site U1320 (λ* ˜ 0.2 to 0.8 and λ* ˜ 0.8, respectively). We use these data to define an average vertical effective stress gradient. Assuming that void ratio (e) is proportional to the log of vertical effective stress (σ'v), we predict pore pressures (u) throughout the mudstone at both sites using bulk density data. Overpressures are greater at Site U1320 due to rapid deposition of the overlying turbidites. However, a large fraction of the overpressure induced by the turbidite load applied at Site U1320 has dissipated by drainage into the overlying basin fill. High overpressures near the seafloor drive shallow fluid flow, reduce slope stability, and may explain large submarine landslides.

  13. Effects of Health Insurance Interruption on Loss of Hypertension Control in Women With and Women Without HIV.

    PubMed

    Edmonds, Andrew; Ludema, Christina; Eron, Joseph J; Cole, Stephen R; Adedimeji, Adebola A; Cohen, Mardge H; Cooper, Hannah L; Fischl, Margaret; Johnson, Mallory O; Krause, Denise D; Merenstein, Dan; Milam, Joel; Wilson, Tracey E; Adimora, Adaora A

    2017-12-01

    Among low-income women with and without HIV, it is a priority to reduce age-related comorbidities, including hypertension and its sequelae. Because consistent health insurance access has been identified as an important factor in controlling many chronic diseases, we estimated the effects of coverage interruption on loss of hypertension control in a cohort of women in the United States. We analyzed prospective, longitudinal data from the Women's Interagency HIV Study. HIV-infected and HIV-uninfected women were included between 2005 and 2014 when they reported health insurance at consecutive biannual visits and had controlled hypertension, and were followed for any insurance break and loss of hypertension control. We estimated hazard ratios (HRs) by Cox proportional hazards regression with inverse-probability-of-treatment-and censoring weights (marginal structural models), and plotted the cumulative incidence of hypertension control loss. Among 890 HIV-infected women, the weighted HR for hypertension control loss comparing health insurance interruption to uninterrupted coverage was 1.37 (95% confidence interval [CI], 0.99-1.91). Inclusion of AIDS Drug Assistance Program (ADAP) participation with health insurance modestly increased the HR (1.47; 95% CI, 1.04-2.07). Analysis of 272 HIV-uninfected women yielded a similar HR (1.39; 95% CI, 0.88-2.21). Additionally, there were indications of uninterrupted coverage having a protective effect on hypertension when compared with the natural course in HIV-infected (HR, 0.82; 95% CI, 0.61-1.11) and HIV-uninfected (HR, 0.78; 95% CI, 0.52-1.19) women. This study provides evidence that health insurance continuity promotes hypertension control in key populations. Interventions that ensure coverage stability and ADAP access should be a policy priority.

  14. Protocol for a Controlled Experiment to Identify the Causal Role of Acute Alcohol Consumption in Condomless Sex among HIV-Positive MSM: Study Procedures, Ethical Considerations, and Implications for HIV Prevention.

    PubMed

    Shuper, Paul A; Joharchi, Narges; Rehm, Jürgen

    2016-01-01

    Although alcohol consumption is frequently perceived as a driver of condomless sex and subsequent HIV acquisition, the causal nature of this relationship remains unclear, and little is known about alcohol's direct versus indirect impact on the sexual risk dynamics of those who are HIV-positive. To address this gap, we present the protocol for an in-progress NIAAA-funded controlled experiment, wherein a sample of HIV-positive men-who-have-sex-with-men (MSM) undergoes an alcohol consumption manipulation (alcohol/placebo/control) and sexual arousal induction (sexually aroused/non-aroused), and then reports intentions to engage in condom-protected and condomless sexual acts with hypothetical sexual partners differing in HIV serostatus (HIV+/HIV-/HIV status unknown), condom use preference (use/don't use/not stated), and physical attractiveness (attractive/unattractive). Study outcomes will identify alcohol's impact on HIV-positive MSM's condomless sex intentions in the context of experimentally-manipulated factors as well as risk-relevant personality traits and alcohol-related expectancies. Detailed experimental procedures, ethical considerations, and potential implications for HIV prevention are discussed.

  15. Macro-level implicit HIV prejudice and the health of community residents with HIV.

    PubMed

    Miller, Carol T; Varni, Susan E; Solomon, Sondra E; DeSarno, Michael J; Bunn, Janice Y

    2016-08-01

    This study examined how community levels of implicit HIV prejudice are associated with the psychological and physical well-being of people with HIV living in those same communities. It also examined whether community motivation to control prejudice and/or explicit HIV prejudice moderates the relationship of implicit prejudice and well-being. Participants were 206 people with HIV living in 42 different communities in New England who completed measures that assessed psychological distress, thriving, and physical well-being. Telephone surveys of 347 residents of these same communities (selected via random digit dialing) were used to assess community explicit HIV prejudice and motivation to control HIV prejudice. These community residents then completed an online measure of implicit prejudice toward people with HIV, the Implicit Association Test (IAT; Greenwald, McGhee, & Schwartz, 1998). Multilevel analyses showed that higher community implicit HIV prejudice was associated with greater psychological distress among residents with HIV living in that community. The physical well-being of participants with HIV was negatively related to community implicit HIV prejudice in communities in which residents were unmotivated to control HIV prejudice or had high levels of explicit HIV prejudice. These findings indicate that implicit prejudice of residents of real-world communities may create an environment that may impair the well-being of stigmatized people. Implicit prejudice can therefore be considered an element of macro-level or structural stigma. The discussion considered the possible role of implicit HIV prejudice on a community's social capital as a pathway by which it compromises the well-being of residents with HIV. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  16. Macro-level Implicit HIV Prejudice and the Health of Community Residents with HIV

    PubMed Central

    Miller, Carol T.; Varni, Susan E.; Solomon, Sondra E.; DeSarno, Michael J.; Bunn, Janice Y.

    2016-01-01

    Objectives This study examined how community levels of implicit HIV prejudice are associated with the psychological and physical well-being of people with HIV living in those same communities. It also examined whether community motivation to control prejudice and/or explicit HIV prejudice moderates the relationship of implicit prejudice and well-being. Methods Participants were 206 people with HIV living in 42 different communities in New England who completed measures that assessed psychological distress, thriving, and physical well-being. Telephone surveys of 347 residents of these same communities (selected via random digit dialing) were used to assess community explicit HIV prejudice and motivation to control HIV prejudice. These community residents then completed an on-line measure of implicit prejudice toward people with HIV, the Implicit Association Test (IAT, Greenwald et al., 1998). Results Multilevel analyses showed that higher community implicit HIV prejudice was associated with greater psychological distress among residents with HIV living in that community. The physical well-being of participants with HIV was negatively related to community implicit HIV prejudice in communities in which residents were unmotivated to control HIV prejudice or had high levels of explicit HIV prejudice. Conclusions These findings indicate that implicit prejudice of residents of real-world communities may create an environment that may impair the well-being of stigmatized people. Implicit prejudice can therefore be considered an element of macro-level or structural stigma. The discussion considered the possible role of implicit HIV prejudice on a community’s social capital as one pathway by which it compromises the well-being of residents with HIV. PMID:27505199

  17. Re-thinking global health sector efforts for HIV and tuberculosis epidemic control: promoting integration of programme activities within a strengthened health system.

    PubMed

    Maher, Dermot

    2010-07-05

    The global financial crisis threatens global health, particularly exacerbating diseases of inequality, e.g. HIV/AIDS, and diseases of poverty, e.g. tuberculosis. The aim of this paper is to reconsider established practices and policies for HIV and tuberculosis epidemic control, aiming at delivering better results and value for money. This may be achieved by promoting greater integration of HIV and tuberculosis control programme activities within a strengthened health system. HIV and tuberculosis share many similarities in terms of their disease burden and the recommended stratagems for their control. HIV and tuberculosis programmes implement similar sorts of control activities, e.g. case finding and treatment, which depend for success on generic health system issues, including vital registration, drug procurement and supply, laboratory network, human resources, and financing. However, the current health system approach to HIV and tuberculosis control often involves separate specialised services. Despite some recent progress, collaboration between the programmes remains inadequate, progress in obtaining synergies has been slow, and results remain far below those needed to achieve universal access to key interventions. A fundamental re-think of the current strategic approach involves promoting integrated delivery of HIV and tuberculosis programme activities as part of strengthened general health services: epidemiological surveillance, programme monitoring and evaluation, community awareness of health-seeking behavior, risk behaviour modification, infection control, treatment scale-up (first-line treatment regimens), drug-resistance surveillance, containing and countering drug-resistance (second-line treatment regimens), research and development, global advocacy and global partnership. Health agencies should review policies and progress in HIV and tuberculosis epidemic control, learn mutual lessons for policy development and scaling up interventions, and identify ways of joint planning and joint funding of integrated delivery as part of strengthened health systems. As both a danger and an opportunity, the global financial crisis may entail disaster or recovery for global health sector efforts for HIV and tuberculosis epidemic control. Review of policies and progress in control paves the way for identification of synergies between the two programmes, within strengthened health services. The silver lining in the global economic crisis could be better control of the HIV and tuberculosis epidemics, better overall health system performance and outcomes, and better value for money.

  18. Conspiracy beliefs about HIV/AIDS and birth control among African Americans: implications for the prevention of HIV, other STIs, and unintended pregnancy.

    PubMed

    Bird, Sheryl Thorburn; Bogart, Laura M

    2005-03-01

    In this article, we examine the potential role that conspiracy beliefs regarding HIV/AIDS (e.g., "HIV is a manmade virus") and birth control (e.g., "The government is trying to limit the Black population by encouraging the use of condoms") play in the prevention of HIV, other STIs, and unintended pregnancies among African Americans in the United States. First, we review prior research indicating that substantial percentages of African Americans endorse conspiracy beliefs about HIV/AIDS and birth control. Next, we present a theoretical framework that suggests how conspiracy beliefs influence sexual behavior and attitudes. We then offer several recommendations for future research. Finally, we discuss the policy and programmatic implications of conspiracy beliefs for the prevention of HIV, other STIs, and unintended pregnancy.

  19. [Detecting the markers of HIV infection with the new enzyme immunoassay diagnostic kit "DS-EIA-HIV-AB-AG-SPECTRUM" at the laboratories of AIDS prevention and control centers in the Volga Federal District].

    PubMed

    Ivanova, N I; Peksheva, O Iu

    2009-03-01

    A possibility of simultaneously detecting specific antibodies to HIV-1 and HIV-2 by enzyme immunoassay (EIA) at lower concentrations than those by immunoblotting (IB), and well as an additional possibility of earlier diagnosis of HIV infection, by identifying the HIV-1 antigen p24 lay the foundation of the "DS-EIA-HIV-AB-AG-SPECTRUM" test system made by OOO "Research-and-Production Association "Diagnosticheskiye Sistemy" (Diagnostic Systems). These peculiarities were compared with those of IB at a number of laboratories of AIDS prevention and control centers in the Volga Federal District, by using native serum/plasma samples and a specially designed control panel. The analysis of the conducted studies to identify HIV-1 and HIV-2 antibodies and HIV-1 antigen p24 in 65 plasma/serum samples in the "DS-EIA-HIV-AB-AG-SPECTRUM" and "LIA-HIV-1/2" (OOO "Niarmedik plus") test systems while confirming the positive result indicated agreement in 57 (87.7%) cases. The diagnostic possibilities of the "DS-EIA-HIV-AB-AG-SPECTRUM" test system versus the "New Lav-Blot I" one to make a laboratory diagnosis of HIV infection were studied. Irrefragable answers as to the availability of HIV-1 markers in the study serum samples on the enciphered panel were provided by IB in 73.3% of cases and EIA in 92%.

  20. Programmatic Cost Evaluation of Nontargeted Opt-Out Rapid HIV Screening in the Emergency Department

    PubMed Central

    Haukoos, Jason S.; Campbell, Jonathan D.; Conroy, Amy A.; Hopkins, Emily; Bucossi, Meggan M.; Sasson, Comilla; Al-Tayyib, Alia A.; Thrun, Mark W.

    2013-01-01

    Background The Centers for Disease Control and Prevention recommends nontargeted opt-out HIV screening in healthcare settings. Cost effectiveness is critical when considering potential screening methods. Our goal was to compare programmatic costs of nontargeted opt-out rapid HIV screening with physician-directed diagnostic rapid HIV testing in an urban emergency department (ED) as part of the Denver ED HIV Opt-Out Trial. Methods This was a prospective cohort study nested in a larger quasi-experiment. Over 16 months, nontargeted rapid HIV screening (intervention) and diagnostic rapid HIV testing (control) were alternated in 4-month time blocks. During the intervention phase, patients were offered HIV testing using an opt-out approach during registration; during the control phase, physicians used a diagnostic approach to offer HIV testing to patients. Each method was fully integrated into ED operations. Direct program costs were determined using the perspective of the ED. Time-motion methodology was used to estimate personnel activity costs. Costs per patient newly-diagnosed with HIV infection by intervention phase, and incremental cost effectiveness ratios were calculated. Results During the intervention phase, 28,043 eligible patients were included, 6,933 (25%) completed testing, and 15 (0.2%, 95% CI: 0.1%–0.4%) were newly-diagnosed with HIV infection. During the control phase, 29,925 eligible patients were included, 243 (0.8%) completed testing, and 4 (1.7%, 95% CI: 0.4%–4.2%) were newly-diagnosed with HIV infection. Total annualized costs for nontargeted screening were $148,997, whereas total annualized costs for diagnostic HIV testing were $31,355. The average costs per HIV diagnosis were $9,932 and $7,839, respectively. Nontargeted HIV screening identified 11 more HIV infections at an incremental cost of $10,693 per additional infection. Conclusions Compared to diagnostic testing, nontargeted HIV screening was more costly but identified more HIV infections. More effective and less costly testing strategies may be required to improve the identification of patients with undiagnosed HIV infection in the ED. PMID:24391706

  1. The immunological response to syphilis differs by HIV status; a prospective observational cohort study.

    PubMed

    Kenyon, Chris; Osbak, Kara Krista; Crucitti, Tania; Kestens, Luc

    2017-01-31

    It is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals. We prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy. A total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study. At the baseline visit, compared to the control group, concentrations of IL-10 were significantly elevated in the HIV-infected and uninfected groups. The level of IL-10 was significantly higher in the HIV-infected compared to the HIV-uninfected PSS group (25.3 pg/mL (IQR, 4.56-41.76) vs 2.73 pg/mL (IQR, 1.55-9.02), P = 0.0192). In the HIV-infected PSS group (but not the HIV-infected LS or HIV-uninfected PSS groups) the IP-10, MIP-1b, IL-6 and IL-8 were raised compared to the controls. IL-10 levels decreased but did not return to control baseline values by 6 months in HIV infected PSS and LS and HIV uninfected PSS. PSS and LS in HIV-infected individuals is characterized by an increase in inflammatory and anti-inflammatory cytokines such as IL-10. The increase of IL-10 is greater in HIV-infected than uninfected individuals. Further work is required to ascertain if this is part of an immunological profile that correlates with adverse outcomes such as serofast syphilis and neurosyphilis, in HIV-infected individuals.

  2. Amino Acid Concentrations in HIV-Infected Youth Compared to Healthy Controls and Associations with CD4 Counts and Inflammation.

    PubMed

    Ziegler, Thomas R; Judd, Suzanne E; Ruff, Joshua H; McComsey, Grace A; Eckard, Allison Ross

    2017-07-01

    Amino acids play critical roles in metabolism, cell function, body composition and immunity, but little data on plasma amino acid concentrations in HIV are available. We evaluated plasma amino acid concentrations and associations with CD4 counts and inflammatory biomarkers in HIV-infected youth. HIV-infected subjects with a high (≥500 cells/mm 3 ) and low (<500 cells/mm 3 ) current CD4 + T cell counts were compared to one another and to a matched healthy control group. Plasma concentrations of 19 amino acids were determined with an amino acid analyzer. Plasma levels of interleukin-6, tumor necrosis factor receptor-I, and soluble vascular cellular adhesion molecule-I were also measured. Seventy-nine HIV-infected subjects (40 and 39 with high and low CD4 + T cell counts, respectively) and 40 controls were included. There were no differences in amino acid concentrations between HIV-infected subjects with high or low CD4 + T cell counts. When combined, the HIV-infected group exhibited significantly lower median plasma concentrations compared to controls for total, essential, branched-chain and sulfur amino acids, as well as for 12 individual amino acids. Glutamate was the only amino acid that was higher in the HIV-infected group. There were no significant correlations between amino acid endpoints and inflammatory biomarkers for either HIV-infected group or controls. Plasma amino acid concentrations were lower in HIV-infected youth compared to healthy controls, regardless of immune status, while glutamate concentrations were elevated. These findings can inform future interventional studies designed to improve metabolic and clinical parameters influenced by amino acid nutriture.

  3. Strongyloidiasis Epidemiology and Treatment Response in Patients with HIV Infection

    PubMed Central

    Cortes-Penfield, Nicolas; Moore, Cody; Arduino, Roberto; Serpa, Jose

    2017-01-01

    Abstract Background We sought to characterize the epidemiology of HIV and S. stercoralis coinfection in an urban HIV cohort, and to investigate the effect of S. stercoralis infection on HIV virologic control and immune recovery. Methods We reviewed the medical records of all HIV-infected patients diagnosed with strongyloidiasis who received care at Thomas Street Health Center (Houston, TX) between 2000 and 2015. For each case we included up to two matched HIV-infected patients without strongyloidiasis (controls). Matching was based on age, sex, ethnicity, baseline CD4 percentage, and HIV viral load at the time of strongyloidiasis diagnosis in the case patient. We recorded patient demographics, comorbidities, CD4 count and percentage, HIV viral load, and absolute eosinophilia count (AEC) at the time of HIV diagnosis, strongyloidiasis diagnosis, and six and twelve months after ivermectin treatment. Results We identified 15 cases of HIV and S.stercoralis coinfection; 13 had at least one available matched control. The mean age of coinfected patients was 45; all were Hispanic, 84.6% were male, and the mean CD4 nadir was 146 cells/ul. At the time of strongyloidiasis diagnosis, the mean CD4 count was 460 cells/ul, HIV RNA viral load 2.07 logs/ml, and AEC was 1,360 cells/μL. At 6 and 12 months after treatment, CD4 counts were 514 and 464 cells/μL, HIV RNA viral loads 1.78 and 2.31 log/mL, and AECs 319 and 362 cells/μL, respectively. Although CD4 counts increased 6 months after treatment, they returned to baseline levels at 12 months; neither change achieved statistical significance. The reduction in AECs after ivermectin treatment was statistically significant (P < 0.001). Matched controls without S.stercoralis had lower AECs at baseline, 6 months, and 12 months; otherwise, there were no differences between cases and controls. Conclusion Strongyloidiasis treatment in HIV-infected patients led to normalization of the AEC at 6 months in most cases, but AECs remained higher than in control patients. Persistently elevated AECs may suggest treatment failure or reinfection. Our study was unable to identify any effect of S. stercoralis infection or treatment on HIV virologic suppression or immunologic recovery; larger studies are warranted to investigate the effect of strongyloidiasis on HIV disease. Disclosures All authors: No reported disclosures.

  4. Mucosal immunity in HIV controllers: the right place at the right time.

    PubMed

    Shacklett, Barbara L; Ferre, April L

    2011-05-01

    The phenomenon of long-term nonprogression in HIV infection has been recognized for some time, and the ability of rare individuals, designated 'elite controllers', to control HIV in the absence of therapy is the focus of numerous ongoing studies. This review focuses on studies of HIV-specific immune responses in mucosal tissues as a potential correlate of immune control, with an emphasis on recently published work. Genetic studies have implicated a role for elements localized to the major histocompatibility complex (MHC) on chromosome 6 in the immune control of HIV infection. In parallel, functional studies have strongly implicated MHC class I-restricted, CD8+ T-cell responses as a major contributor to elite control. In addition, the localization of HIV-specific CD8+ and CD4+ T cells with respect to the major sites of virus replication in the body may be critical in determining clinical outcome. Recent findings suggest that MHC class I-restricted, CD8+ T cells are a major component of immune control in 'elite controllers'. In addition, the presence of these effector cells at or near critical viral reservoirs, such as mucosal tissues, may be critical in determining their effectiveness at limiting viral replication and dissemination.

  5. Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy

    PubMed Central

    Connick, Elizabeth; MaWhinney, Samantha; Chan, Edward D.; Flores, Sonia C.

    2014-01-01

    Low levels of the vitamin D-regulated antimicrobial peptide cathelicidin (LL-37) may negatively impact the immune status of human immunodeficiency virus-1 (HIV-1) infected individuals (HIV+). We compared plasma LL-37 levels in healthy controls (HIV−) and HIV+ individuals on or off antiretroviral therapies (ARTs) (ART+ and ART−, respectively), and evaluated the relationship between vitamin D and LL-37 levels. In this cross-sectional study, levels of LL-37, 25-hydroxycholecalciferol [25(OH)D3] and 1,25-dihydroxycholecalciferol [1,25(OH)2D3] were measured from an initial cohort of 18 healthy controls and 10 HIV+/ART− individuals. Because this cohort lacked HIV+/ART+ subjects, LL-37 was also quantified from a second cohort of 10 HIV+/ART− and 13 HIV+/ART+ individuals. LL-37 levels were significantly lower in the HIV+/ART− group compared to the healthy controls (P = 0.01). A direct relationship was observed between LL-37 and both 25(OH)D3 and 1,25(OH)2D3. The level of 25(OH)D3 was predictive of higher LL-37 (P = 0.04) and for any given level of 25(OH)D3, HIV+/ART− subjects averaged 20 % lower LL-37 compared to the healthy controls (P = 0.045). For any given level of 1,25(OH)2D3, HIV+/ART− subjects averaged 25 % lower LL-37 compared to the healthy controls (P = 0.018), although 1,25(OH)2D3 was not predictive of higher LL-37 (P = 0.28). Finally, LL-37 levels were significantly lower in the HIV+/ART− group compared to the HIV+/ART+ group from the second cohort (P = 0.045). Untreated HIV infection may contribute to lower LL-37 levels, independent of vitamin D levels. ART treatment may potentially mitigate this decrease in LL-37 levels. PMID:24821067

  6. Evaluating the impact of the HIV pandemic on measles control and elimination.

    PubMed

    Helfand, Rita F; Moss, William J; Harpaz, Rafael; Scott, Susana; Cutts, Felicity

    2005-05-01

    To estimate the impact of the HIV pandemic on vaccine-acquired population immunity to measles virus because high levels of population immunity are required to eliminate transmission of measles virus in large geographical areas, and HIV infection can reduce the efficacy of measles vaccination. A literature review was conducted to estimate key parameters relating to the potential impact of HIV infection on the epidemiology of measles in sub-Saharan Africa; parameters included the prevalence of HIV, child mortality, perinatal HIV transmission rates and protective immune responses to measles vaccination. These parameter estimates were incorporated into a simple model, applicable to regions that have a high prevalence of HIV, to estimate the potential impact of HIV infection on population immunity against measles. The model suggests that the HIV pandemic should not introduce an insurmountable barrier to measles control and elimination, in part because higher rates of primary and secondary vaccine failure among HIV-infected children are counteracted by their high mortality rate. The HIV pandemic could result in a 2-3% increase in the proportion of the birth cohort susceptible to measles, and more frequent supplemental immunization activities (SIAs) may be necessary to control or eliminate measles. In the model the optimal interval between SIAs was most influenced by the coverage rate for routine measles vaccination. The absence of a second opportunity for vaccination resulted in the greatest increase in the number of susceptible children. These results help explain the initial success of measles elimination efforts in southern Africa, where measles control has been achieved in a setting of high HIV prevalence.

  7. Short Communication: Low Expression of Activation and Inhibitory Molecules on NK Cells and CD4(+) T Cells Is Associated with Viral Control.

    PubMed

    Taborda, Natalia A; Hernández, Juan C; Lajoie, Julie; Juno, Jennifer A; Kimani, Joshua; Rugeles, María T; Fowke, Keith R

    2015-06-01

    Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4(+) T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF-α and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.

  8. The Relevancy of the Clausewitzian Trinity to the War on Terrorism

    DTIC Science & Technology

    2002-04-14

    Jordan, Tajikistan, Uzbekistan, Syria, China, Pakistan, Bangladesh, Malaysia , Myanmar, Indonesia, Philippines, Lebanon, Iraq, Saudi Arabia, Kuwait...routinely discounted. American patriotism, obesity , emotionality, self-centeredness: these are the crucial issues.”111

  9. 28. MCDONALD RANCH: VIEW OF RANCH HOUSE FROM WESTSOUTHWEST, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. MCDONALD RANCH: VIEW OF RANCH HOUSE FROM WEST-SOUTHWEST, WITH OSCURA MOUNTAINS IN BACKGROUND - White Sands Missile Range, Trinity Site, Vicinity of Routes 13 & 20, White Sands, Dona Ana County, NM

  10. 27 CFR 9.184 - Trinity Lakes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... Provisional Edition 1986; (2) Whisky Bill Peak, Calif. Provisional Edition 1986; (3) Damnation Peak, Calif...) Proceed due east on township line T37N/T36N onto the Whisky Bill Peak, California quadrangle map to the...

  11. 27 CFR 9.184 - Trinity Lakes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... Provisional Edition 1986; (2) Whisky Bill Peak, Calif. Provisional Edition 1986; (3) Damnation Peak, Calif...) Proceed due east on township line T37N/T36N onto the Whisky Bill Peak, California quadrangle map to the...

  12. 77 FR 46682 - Trinity County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... Rural Schools one-year extension to the 2008-2011 RAC authorization, and recruitment of new RAC..., overview of one-year extension, and new RAC committee member recruitment. An agenda of the meeting is also...

  13. Regulation of oxidative stress in response to acute aerobic and resistance exercise in HIV-infected subjects: a case-control study.

    PubMed

    Deresz, L F; Sprinz, E; Kramer, A S; Cunha, G; de Oliveira, A R; Sporleder, H; de Freitas, D R J; Lazzarotto, A R; Dall'Ago, P

    2010-11-01

    Human immunodeficiency virus (HIV)-infected subjects have increased levels of oxidative stress which could impair immunological function and therefore contribute to the progression of AIDS. These characteristics are usually evaluated at rest and responses to exercise have yet to be evaluated. The aim of the present study was to assess the effect of a bout of aerobic exercise followed by resistance exercises on antioxidant system in HIV-infected and non-HIV subjects. There were included 14 cases (HIV-positive) and 14 controls (HIV-negative). The exercise protocol consisted of a single session of 20 minutes on a cycloergometer followed by a set of six resistance exercises. The activity of glutathione S-transferase (GST) and catalase were measured in plasma samples, total glutathione (TGSH) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes. T CD4+ cells, T CD8+, viral load, complete blood count, and white blood count were also assessed. All measurements were performed at three times: baseline, after aerobic exercise, and after resistance exercises. At baseline, the HIV group had lower GST activity than controls, but after the exercise session GST values were similar in both groups. Compared to the control group TGSH was significantly lower in the HIV group at baseline, after aerobic and resistance exercises. The control group presented higher TBARS values after aerobic exercise compared to the HIV group. The neutrophil count was lower in the HIV group after aerobic and resistance exercises. These data indicate that HIV-infected subjects had lower antioxidant activity at rest. Physical exercise stimulated the enzymatic activity similarly in both groups.

  14. Seroprevalence of antibodies to measles, mumps, and rubella, and serologic responses after vaccination among human immunodeficiency virus (HIV)-1 infected adults in Northern Thailand.

    PubMed

    Chaiwarith, Romanee; Praparattanapan, Jutarat; Nuket, Khanuengnit; Kotarathitithum, Wilai; Supparatpinyo, Khuanchai

    2016-04-30

    After the global implementation of national immunization programs for prevention of measles, mumps, and rubella (MMR), the prevalences of protective antibodies to these viruses are high in general population. However, there are limited data among human immunodeficiency virus (HIV)-1 infected individuals. This study aimed to determine the seroprevalence of antibodies to these viruses, and the serologic responses after vaccination among HIV-infected adults in Northern Thailand. A cross-sectional study was conducted in 500 HIV-infected adults, aged 20-59 years, receiving combination antiretroviral therapy, CD4 cell count ≥200 cells/mm(3), and plasma HIV-1 RNA <50 copies/mL, and 132 HIV-uninfected controls, aged 20-59 years, at Chiang Mai University Hospital during July and August 2011. Prevalences of protective antibodies to these viruses as well as serologic responses after MMR vaccination in those without protective antibody to at least one of the three viruses were compared between groups. The prevalences of protective antibodies to measles, mumps, and rubella were 94.2, 55.0, and 84.6 % among HIV-infected adults, and 97.7, 67.5, and 89.4 % among HIV-uninfected controls, respectively. The prevalence of protective antibody to mumps was significantly lower in HIV-infected adults (p-value = 0.010). MMR vaccination was done in 249 HIV-infected and 46 HIV-uninfected controls; at week 8 to 12 after vaccination, the seroprotective rates against measles, mumps, and rubella in HIV-infected adults were 96.4, 70.7, and 98.0 %, respectively, whereas those in HIV-uninfected controls were 100, 87, and 100 %, respectively. No serious adverse effects were observed. In contrast to measles and rubella, the prevalence of protective antibody to mumps was low in both HIV-infected adults and HIV-uninfected controls in northern Thailand. The seroprotective rates after MMR vaccination in both groups were considerably high, except only for mumps. Therefore, MMR vaccination should be considered in all HIV-infected adults receiving antiretroviral therapy with undetectable plasma HIV-1 RNA and CD4 cell count ≥200 cells/mm(3). ClinicalTrials.gov: NCT02724852 , registered on March 31, 2016.

  15. Evaluating the Implications of Climate Phenomenon Indices in Supporting Reservoir Operation Using the Artificial Neural Network and Decision-Tree Methods: A Case Study on Trinity Lake in Northern California

    NASA Astrophysics Data System (ADS)

    Yang, T.; Akbari Asanjan, A.; Gao, X.; Sorooshian, S.

    2016-12-01

    Reservoirs are fundamental human-built infrastructures that collect, store, and deliver fresh surface water in a timely manner for all kinds of purposes, including residential and industrial water supply, flood control, hydropower, and irrigation, etc. Efficient reservoir operation requires that policy makers and operators understand how reservoir inflows, available storage, and discharges are changing under different climatic conditions. Over the last decade, the uses of Artificial Intelligence and Data Mining (AI & DM) techniques in assisting reservoir management and seasonal forecasts have been increasing. Therefore, in this study, two distinct AI & DM methods, Artificial Neural Network (ANN) and Random Forest (RF), are employed and compared with respect to their capabilities of predicting monthly reservoir inflow, managing storage, and scheduling reservoir releases. A case study on Trinity Lake in northern California is conducted using long-term (over 50 years) reservoir operation records and 17 known climate phenomenon indices, i.e. PDO and ENSO, etc., as predictors. Results show that (1) both ANN and RF are capable of providing reasonable monthly reservoir storage, inflow, and outflow prediction with satisfactory statistics, and (2) climate phenomenon indices are useful in assisting monthly or seasonal forecasts of reservoir inflow and outflow. It is also found that reservoir storage has a consistent high autocorrelation effect, while inflow and outflow are more likely to be influenced by climate conditions. Using a Gini diversity index, RF method identifies that the reservoir discharges are associated with Southern Oscillation Index (SOI) and reservoir inflows are influenced by multiple climate phenomenon indices during different seasons. Furthermore, results also show that, during the winter season, reservoir discharges are controlled by the storage level for flood-control purposes, while, during the summer season, the flood-control operation is not as significant as that in the winter. With regard to the suitability of the AI & DM methods in support of reservoir operation, the Decision Tree method is suggested for future reservoir studies because of its transparency and non-parametric features over the "black-box" style ANN regression model.

  16. HIV-specific CD8+ T cells: serial killers condemned to die?

    PubMed

    Petrovas, Constantinos; Mueller, Yvonne M; Katsikis, Peter D

    2004-04-01

    An increasing body of evidence supports a key role for cytotoxic CD8+ T cells (CTL) in controlling HIV infection. Although a vigorous HIV-specific CD8+ T cell response is raised during the primary infection, these cells ultimately fail to control virus and prevent disease progression. The failure of CTL to control HIV infection has been attributed to a number of strategies HIV employs to evade the immune system. Recently, intrinsic defects in the CTL themselves have been proposed to contribute to the failure of CTL to control HIV. HIV-specific CD8+ T cells differ in their effector/memory phenotype from other virus-specific CD8+ T cells indicating that their differentiation status differs. This altered differentiation may affect effector functions as well as homing properties of these cells. Other studies have indicated that activation of HIV-specific CTL may be impaired and this contributes to their dysfunction. The effector function of these CTL may also be affected. There are conflicting reports about their ability to kill, whereas IFNgamma production does not appear to be impaired in these cells. In this review we focus on recent work indicating that apoptosis may be an important mechanism through which HIV evades the CTL response. In particular, HIV-specific CD8+ T cells are highly susceptible to CD95/Fas-induced apoptosis. This leads to the hypothesis that virus-specific cytotoxic T cells can be eliminated upon binding CD95L/FasL on HIV-infected cells. Understanding the intrinsic defects of CTL in HIV infection could lead to new therapeutic strategies and optimized vaccination protocols that enhance the HIV-specific cytotoxic response.

  17. Maternal biochemical serum screening for Down syndrome in pregnancy with human immunodeficiency virus infection.

    PubMed

    Le Meaux, Jean-Patrick; Tsatsaris, Vassilis; Schmitz, Thomas; Fulla, Yvonne; Launay, Odile; Goffinet, François; Azria, Elie

    2008-08-01

    To estimate the influence of human immunodeficiency virus (HIV) infection and antiretroviral therapy on maternal serum markers levels and the false-positive rate with biochemical maternal serum screening for Down syndrome. We performed a 1:1 matched case-control study comparing 132 HIV-infected women with single pregnancy to controls selected among non-HIV-infected women matched on geographical origin and fetal sex. Of HIV-infected women, 47.7% were receiving antiretroviral therapy. Groups did not differ in multiples of the median (MoM) levels of total human chorionic gonadotrophin. The MoM alpha fetoprotein level did not differ between total HIV-infected women and control women but was significantly lower for untreated HIV-positive women compared with control women (0.91 compared with 1.03 MoM, P<.01) and compared with treated HIV-positive women (0.91 compared with 1.18 MoM, P<.01). The false-positive rate of biochemical screening did not differ between groups. Untreated HIV infection is associated with lower maternal serum alpha fetoprotein levels. Nevertheless, the false-positive rate of double-marker second-trimester Down syndrome serum screening did not appear to be affected in our sample of HIV-infected women, whether women were receiving antiretroviral therapy at the time of the test or not.

  18. Missed opportunities for HIV testing in health care settings among young African American men who have sex with men: implications for the HIV epidemic.

    PubMed

    Dorell, Christina G; Sutton, Madeline Y; Oster, Alexandra M; Hardnett, Felicia; Thomas, Peter E; Gaul, Zaneta J; Mena, Leandro A; Heffelfinger, James D

    2011-11-01

    Limited health care access and missed opportunities for HIV and other sexually transmitted infection (STI) education and testing in health care settings may contribute to risk of HIV infection. In 2008, we conducted a case-control study of African American men who have sex with men (MSM) in a southeastern city (Jackson, Mississippi) with an increase in numbers of newly reported HIV cases. Our aims were to evaluate associations between health care and HIV infection and to identify missed opportunities for HIV/STI testing. We queried 40 potential HIV-infected cases and 936 potential HIV-uninfected controls for participation in this study. Study enrollees included HIV-infected cases (n=30) and HIV-uninfected controls (n=95) who consented to participate and responded to a self-administered computerized survey about sexual risk behaviors and health care utilization. We used bivariate analysis and logistic regression to test for associations between potential risk factors and HIV infection. Cases were more likely than controls to lack health insurance (odds ratio [OR]=2.5; 95% confidence interval [CI]=1.1-5.7), lack a primary care provider (OR=6.3; CI=2.3-16.8), and to not have received advice about HIV or STI testing or prevention (OR=5.4; CI=1.3-21.5) or disclose their sexual identity (OR=7.0; CI=1.6-29.2) to a health care provider. In multivariate analysis, lacking a primary health care provider (adjusted odds ratio [AOR]=4.5; CI=1.4-14.7) and not disclosing sexual identity to a health care provider (AOR=8.6; CI=1.8-40.0) were independent risk factors for HIV infection among African American MSM. HIV prevention interventions for African American MSM should address access to primary health care providers for HIV/STI prevention and testing services and the need for increased discussions about sexual health, sexual identity, and sexual behaviors between providers and patients in an effort to reduce HIV incidence and HIV-related health disparities.

  19. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.

    PubMed

    Klein, Florian; Halper-Stromberg, Ariel; Horwitz, Joshua A; Gruell, Henning; Scheid, Johannes F; Bournazos, Stylianos; Mouquet, Hugo; Spatz, Linda A; Diskin, Ron; Abadir, Alexander; Zang, Trinity; Dorner, Marcus; Billerbeck, Eva; Labitt, Rachael N; Gaebler, Christian; Marcovecchio, Paola; Incesu, Reha-Baris; Eisenreich, Thomas R; Bieniasz, Paul D; Seaman, Michael S; Bjorkman, Pamela J; Ravetch, Jeffrey V; Ploss, Alexander; Nussenzweig, Michel C

    2012-12-06

    Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection. Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time. However, these experiments were performed before the recent discovery of more potent anti-HIV-1 antibodies and their improvement by structure-based design. Here we re-examine passive antibody transfer as a therapeutic modality in HIV-1-infected humanized mice. Although HIV-1 can escape from antibody monotherapy, combinations of broadly neutralizing antibodies can effectively control HIV-1 infection and suppress viral load to levels below detection. Moreover, in contrast to antiretroviral therapy, the longer half-life of antibodies led to control of viraemia for an average of 60 days after cessation of therapy. Thus, combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV-1-infected individuals.

  20. Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers.

    PubMed

    Martin-Gayo, Enrique; Buzon, Maria Jose; Ouyang, Zhengyu; Hickman, Taylor; Cronin, Jacqueline; Pimenova, Dina; Walker, Bruce D; Lichterfeld, Mathias; Yu, Xu G

    2015-06-01

    The majority of HIV-1 elite controllers (EC) restrict HIV-1 replication through highly functional HIV-1-specific T cell responses, but mechanisms supporting the evolution of effective HIV-1-specific T cell immunity in these patients remain undefined. Cytosolic immune recognition of HIV-1 in conventional dendritic cells (cDC) can facilitate priming and expansion of HIV-1-specific T cells; however, HIV-1 seems to be able to avoid intracellular immune recognition in cDCs in most infected individuals. Here, we show that exposure of cDCs from EC to HIV-1 leads to a rapid and sustained production of type I interferons and upregulation of several interferon-stimulated effector genes. Emergence of these cell-intrinsic immune responses was associated with a reduced induction of SAMHD1 and LEDGF/p75, and an accumulation of viral reverse transcripts, but inhibited by pharmacological blockade of viral reverse transcription or siRNA-mediated silencing of the cytosolic DNA sensor cGAS. Importantly, improved cell-intrinsic immune recognition of HIV-1 in cDCs from elite controllers translated into stronger abilities to stimulate and expand HIV-1-specific CD8 T cell responses. These data suggest an important role of cell-intrinsic type I interferon secretion in dendritic cells for the induction of effective HIV-1-specific CD8 T cells, and may be helpful for eliciting functional T cell immunity against HIV-1 for preventative or therapeutic clinical purposes.

  1. Control of HIV infection by IFN-α: implications for latency and a cure.

    PubMed

    Bourke, Nollaig M; Napoletano, Silvia; Bannan, Ciaran; Ahmed, Suaad; Bergin, Colm; McKnight, Áine; Stevenson, Nigel J

    2018-03-01

    Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active anti-retroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance.

  2. Innate immunity in the control of HIV/AIDS: recent advances and open questions.

    PubMed

    Ploquin, Mickaël J-Y; Jacquelin, Béatrice; Jochems, Simon P; Barré-Sinoussi, Françoise; Müller-Trutwin, Michaela C

    2012-06-19

    From the publication of the first AIDS issue onwards, major advances have been made in the field of innate immunity during HIV infection. Innate immunity can be defined as the first and unspecific lines of defense constitutively present and ready to be mobilized upon infection. Although a large body of literature adamantly highlights that innate immunity is a critical weapon of defense against HIV and its simian parents (simian immunodeficiency virus, SIV), innate immunity is still underexplored. Focusing on innate immunity may open new paths for the development of innovative therapeutics and vaccine strategies against HIV. Understanding innate immunity may shed light on the natural protection occurring in rare HIV-1-infected individuals who control their infection. This review focuses on innate mechanisms sensing HIV-1 entry and controlling HIV-1 infection, as well as promoting inflammation and shaping adaptive immunity.

  3. HIV shedding in cervico-vaginal secretions in pregnant women.

    PubMed

    Gardella, Barbara; Roccio, Marianna; Maccabruni, Anna; Mariani, Bianca; Panzeri, Lucia; Zara, Francesca; Spinillo, Arsenio

    2011-07-01

    The purpose of this study was to evaluate the presence of HIV-1 in cervico-vaginal secretions of pregnant as compared to non-pregnant HIV-seropositive women. We compared 43 known HIV seropositive pregnant patients versus 241 age-matched (± 2 years) control non-pregnant HIV-seropositive subjects. In pregnant patients blood and cervico-vaginal samples were obtained during each trimester of pregnancy. In control subjects the same samples were obtained at enrolment. HIV-1 RNA was measured in plasma; proviral HIV-1 DNA, cell-associated and cell-free HIV-1 RNA in cervico-vaginal secretion by competitive polymerase chain reaction (cRT-PCR) and reverse transcriptase PCR. The genital shedding of HIV-DNA (22/43 as compared to 79/241, p = 0.02), and cell-free HIV-RNA detection (26/43 as compared to 72/241, p < .001) was more common in first-trimester pregnant than in non pregnant women. Pregnancy correlated with a significant positive trend in the cervico-vaginal load of HIV-DNA (Spearman Rho= 0.149, p= 0.012), and cell-free HIV-RNA (Spearman Rho= 0.253, p < .001), but not of HIV-RNA transcripts (Spearman Rho = 0.06, p= 0.31). After correction for potential confounders, first trimester pregnant women had increased rates of genital HIV- DNA (odds ratio = 1.94, 95% confidence interval = 1.01 3.78) and cell-free HIV-RNA (odds ratio = 4.07, 95% confidence interval = 1.97 8.41) detection compared to nonpregnant controls. The shedding of genital HIV was increased in pregnant compared to non pregnant subjects, even in patients with undetectable viremia. In this low-risk HIV-positive population the risks of vertical or horizontal transmissions should not be underestimated.

  4. Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls

    PubMed Central

    Booiman, Thijs; Wit, Ferdinand W.; Girigorie, Arginell F.; Maurer, Irma; De Francesco, Davide; Sabin, Caroline A.; Harskamp, Agnes M.; Prins, Maria; Franceschi, Claudio; Deeks, Steven G.; Winston, Alan; Reiss, Peter

    2017-01-01

    HIV-1-positive individuals on successful antiretroviral therapy (ART) are reported to have higher rates of age-associated non-communicable comorbidities (AANCCs). HIV-associated immune dysfunction has been suggested to contribute to increased AANCC risk. Here we performed a cross-sectional immune phenotype analysis of T cells in ART-treated HIV-1-positive individuals with undetectable vireamia (HIV-positives) and HIV-1-negative individuals (HIV-negatives) over 45 years of age. In addition, two control groups were studied: HIV negative adults selected based on lifestyle and demographic factors (Co-morBidity in Relation to AIDS, or COBRA) and unselected age-matched donors from a blood bank. Despite long-term ART (median of 12.2 years), HIV-infected adults had lower CD4+ T-cell counts and higher CD8+ T-cell counts compared to well-matched HIV-negative COBRA participants. The proportion of CD38+HLA-DR+ and PD-1+ CD4+ T-cells was higher in HIV-positive cohort compared to the two HIV-negative cohorts. The proportion CD57+ and CD27−CD28− cells of both CD4+ and CD8+ T-cells in HIV-positives was higher compared to unselected adults (blood bank) as reported before but this difference was not apparent in comparison with well-matched HIV-negative COBRA participants. Multiple regression analysis showed that the presence of an increased proportion of terminally differentiated T cells was strongly associated with CMV infection. Compared to appropriately selected HIV-negative controls, HIV-positive individuals on ART with long-term suppressed viraemia exhibited incomplete immune recovery and increased immune activation/exhaustion. CMV infection rather than treated HIV infection appears to have more consistent effects on measures of terminal differentiation of T cells. PMID:28806406

  5. HIV-1 subtype C is not associated with higher risk of heterosexual HIV-1 transmission: a multinational study among HIV-1 serodiscordant couples.

    PubMed

    Kahle, Erin; Campbell, Mary; Lingappa, Jairam; Donnell, Deborah; Celum, Connie; Ondondo, Raphael; Mujugira, Andrew; Fife, Kenneth; Mugo, Nelly; Kapiga, Saidi; Mullins, James I; Baeten, Jared M

    2014-01-14

    HIV-1 subtype C has emerged as the most prevalent strain of HIV-1 worldwide, leading to speculation that subtype C may be more transmissible than other subtypes. We compared the risk of HIV-1 transmission for subtype C versus non-C subtypes (A, D, G and recombinant forms) among heterosexual African HIV-1 serodiscordant couples. We conducted a nested case-control analysis using data from two prospective cohort studies of heterosexual HIV-1 serodiscordant couples from six countries in eastern and southern Africa. Cases (N = 121) included incident HIV-1 transmissions that were established as linked within the serodiscordant partnership by viral sequencing; controls (N = 501) were nontransmitting HIV-1-infected partners. Subtype was determined for partial env and gag genes. Multiple logistic regression controlled for age and gender of the HIV-1-nfected partner and self-reported unprotected sex. Plasma and genital HIV-1 RNA concentrations were compared between subtype C and non-C subtypes using generalized estimating equations. HIV-1 subtype C was not associated with increased risk of HIV-1 transmission compared with non-C subtypes: env adjusted odds ratio (adjOR) 1.14 [95% confidence interval (CI) 0.74-1.75, P = 0.6] and gag adjOR 0.98 (95% CI 0.63-1.52, P = 0.9). Plasma and genital HIV-1 RNA levels did not differ significantly for subtype C versus non-C. In a geographically diverse population of heterosexual African HIV-1 serodiscordant couples, subtype C was not associated with greater risk of HIV-1 transmission compared with non-C subtypes, arguing against the hypothesis that subtype C is more transmissible compared with other common subtypes.

  6. Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms.

    PubMed

    Moroni, Marco; Ghezzi, Silvia; Baroli, Paolo; Heltai, Silvia; De Battista, Davide; Pensieroso, Simone; Cavarelli, Mariangela; Dispinseri, Stefania; Vanni, Irene; Pastori, Claudia; Zerbi, Pietro; Tosoni, Antonella; Vicenzi, Elisa; Nebuloni, Manuela; Wong, Kim; Zhao, Hong; McHugh, Sarah; Poli, Guido; Lopalco, Lucia; Scarlatti, Gabriella; Biassoni, Roberto; Mullins, James I; Malnati, Mauro S; Alfano, Massimo

    2014-12-05

    Understanding the mechanisms by which some individuals are able to naturally control HIV-1 infection is an important goal of AIDS research. We here describe the case of an HIV-1(+) woman, CASE1, who has spontaneously controlled her viremia for the last 14 of her 20 years of infection. CASE1 has been clinically monitored since 1993. Detailed immunological, virological and histological analyses were performed on samples obtained between 2009 and 2011. As for other Elite Controllers, CASE1 is characterized by low to undetectable levels of plasma HIV-1 RNA, peripheral blood mononuclear cell (PBMC) associated HIV-1 DNA and reduced in vitro susceptibility of target cells to HIV-1 infection. Furthermore, a slow rate of virus evolution was demonstrated in spite the lack of assumption of any antiretroviral agent. CASE1 failed to transmit HIV-1 to either her sexual male partner or to her child born by vaginal delivery. Normal values and ratios of T and B cells were observed, along with normal histology of the intestinal mucosa. Attempts to isolate HIV-1 from her PBMC and gut-derived cells were unsuccessful, despite expression of normal cell surface levels of CD4, CCRC5 and CXCR4. CASE1 did not produce detectable anti-HIV neutralizing antibodies in her serum or genital mucosal fluid although she displayed potent T cell responses against HIV-1 Gag and Nef. CASE1 also possessed multiple genetic polymorphisms, including HLA alleles (B*14, B*57, C*06 and C*08.02) and HLA-C single nucleotide polymorphisms (SNPs, rs9264942 C/C and rs67384697 del/del), that have been previously individually associated with spontaneous control of plasma viremia, maintenance of high CD4(+) T cell counts and delayed disease progression. CASE1 has controlled her HIV-1 viremia below the limit of detection in the absence of antiretroviral therapy for more than 14 years and has not shown any sign of immunologic deterioration or disease progression. Co-expression of multiple protective HLA alleles, HLA-C SNPs and strong T cell responses against HIV-1 proteins are the most likely explanation of this very benign case of spontaneous control of HIV-1 disease progression.

  7. Retinal Thickening and Photoreceptor Loss in HIV Eyes without Retinitis.

    PubMed

    Arcinue, Cheryl A; Bartsch, Dirk-Uwe; El-Emam, Sharif Y; Ma, Feiyan; Doede, Aubrey; Sharpsten, Lucie; Gomez, Maria Laura; Freeman, William R

    2015-01-01

    To determine the presence of structural changes in HIV retinae (i.e., photoreceptor density and retinal thickness in the macula) compared with age-matched HIV-negative controls. Cohort of patients with known HIV under CART (combination Antiretroviral Therapy) treatment were examined with a flood-illuminated retinal AO camera to assess the cone photoreceptor mosaic and spectral-domain optical coherence tomography (SD-OCT) to assess retinal layers and retinal thickness. Twenty-four eyes of 12 patients (n = 6 HIV-positive and 6 HIV-negative) were imaged with the adaptive optics camera. In each of the regions of interest studied (nasal, temporal, superior, inferior), the HIV group had significantly less mean cone photoreceptor density compared with age-matched controls (difference range, 4,308-6,872 cones/mm2). A different subset of forty eyes of 20 patients (n = 10 HIV-positive and 10 HIV-negative) was included in the retinal thickness measurements and retinal layer segmentation with the SD-OCT. We observed significant thickening in HIV positive eyes in the total retinal thickness at the foveal center, and in each of the three horizontal B-scans (through the macular center, superior, and inferior to the fovea). We also noted that the inner retina (combined thickness from ILM through RNFL to GCL layer) was also significantly thickened in all the different locations scanned compared with HIV-negative controls. Our present study shows that the cone photoreceptor density is significantly reduced in HIV retinae compared with age-matched controls. HIV retinae also have increased macular retinal thickness that may be caused by inner retinal edema secondary to retinovascular disease in HIV. The interaction of photoreceptors with the aging RPE, as well as possible low-grade ocular inflammation causing diffuse inner retinal edema, may be the key to the progressive vision changes in HIV-positive patients without overt retinitis.

  8. Altered structural brain changes and neurocognitive performance in pediatric HIV.

    PubMed

    Yadav, Santosh K; Gupta, Rakesh K; Garg, Ravindra K; Venkatesh, Vimala; Gupta, Pradeep K; Singh, Alok K; Hashem, Sheema; Al-Sulaiti, Asma; Kaura, Deepak; Wang, Ena; Marincola, Francesco M; Haris, Mohammad

    2017-01-01

    Pediatric HIV patients often suffer with neurodevelopmental delay and subsequently cognitive impairment. While tissue injury in cortical and subcortical regions in the brain of adult HIV patients has been well reported there is sparse knowledge about these changes in perinatally HIV infected pediatric patients. We analyzed cortical thickness, subcortical volume, structural connectivity, and neurocognitive functions in pediatric HIV patients and compared with those of pediatric healthy controls. With informed consent, 34 perinatally infected pediatric HIV patients and 32 age and gender matched pediatric healthy controls underwent neurocognitive assessment and brain magnetic resonance imaging (MRI) on a 3 T clinical scanner. Altered cortical thickness, subcortical volumes, and abnormal neuropsychological test scores were observed in pediatric HIV patients. The structural network connectivity analysis depicted lower connection strengths, lower clustering coefficients, and higher path length in pediatric HIV patients than healthy controls. The network betweenness and network hubs in cortico-limbic regions were distorted in pediatric HIV patients. The findings suggest that altered cortical and subcortical structures and regional brain connectivity in pediatric HIV patients may contribute to deficits in their neurocognitive functions. Further, longitudinal studies are required for better understanding of the effect of HIV pathogenesis on brain structural changes throughout the brain development process under standard ART treatment.

  9. Effectiveness of an HIV/STD risk-reduction intervention for adolescents when implemented by community-based organizations: a cluster-randomized controlled trial.

    PubMed

    Jemmott, John B; Jemmott, Loretta S; Fong, Geoffrey T; Morales, Knashawn H

    2010-04-01

    We evaluated the effectiveness of an HIV/STD risk-reduction intervention when implemented by community-based organizations (CBOs). In a cluster-randomized controlled trial, 86 CBOs that served African American adolescents aged 13 to 18 years were randomized to implement either an HIV/STD risk-reduction intervention whose efficacy has been demonstrated or a health-promotion control intervention. CBOs agreed to implement 6 intervention groups, a random half of which completed 3-, 6-, and 12-month follow-up assessments. The primary outcome was consistent condom use in the 3 months prior to each follow-up assessment, averaged over the follow-up assessments. Participants were 1707 adolescents, 863 in HIV/STD-intervention CBOs and 844 in control-intervention CBOs. HIV/STD-intervention participants were more likely to report consistent condom use (odds ratio [OR] = 1.39; 95% confidence interval [CI] = 1.06, 1.84) than were control-intervention participants. HIV/STD-intervention participants also reported a greater proportion of condom-protected intercourse (beta = 0.06; 95% CI = 0.00, 0.12) than did the control group. This is the first large, randomized intervention trial to demonstrate that CBOs can successfully implement an HIV/STD risk-reduction intervention whose efficacy has been established.

  10. Effectiveness of an HIV/STD Risk-Reduction Intervention for Adolescents When Implemented by Community-Based Organizations: A Cluster-Randomized Controlled Trial

    PubMed Central

    Jemmott, Loretta S.; Fong, Geoffrey T.; Morales, Knashawn H.

    2010-01-01

    Objectives. We evaluated the effectiveness of an HIV/STD risk-reduction intervention when implemented by community-based organizations (CBOs). Methods. In a cluster-randomized controlled trial, 86 CBOs that served African American adolescents aged 13 to 18 years were randomized to implement either an HIV/STD risk-reduction intervention whose efficacy has been demonstrated or a health-promotion control intervention. CBOs agreed to implement 6 intervention groups, a random half of which completed 3-, 6-, and 12-month follow-up assessments. The primary outcome was consistent condom use in the 3 months prior to each follow-up assessment, averaged over the follow-up assessments. Results. Participants were 1707 adolescents, 863 in HIV/STD-intervention CBOs and 844 in control-intervention CBOs. HIV/STD-intervention participants were more likely to report consistent condom use (odds ratio [OR] = 1.39; 95% confidence interval [CI] = 1.06, 1.84) than were control-intervention participants. HIV/STD-intervention participants also reported a greater proportion of condom-protected intercourse (β = 0.06; 95% CI = 0.00, 0.12) than did the control group. Conclusions. This is the first large, randomized intervention trial to demonstrate that CBOs can successfully implement an HIV/STD risk-reduction intervention whose efficacy has been established. PMID:20167903

  11. Physical Theory of the Competition that Allows HIV to Escape from the Immune System

    NASA Astrophysics Data System (ADS)

    Wang, Guanyu; Deem, Michael W.

    2006-11-01

    Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The analytical model reproduces the three stages of HIV-1 infection. We propose a vaccine regimen that may be able to reduce competition between T cells, potentially eliminating the third stage of HIV-1.

  12. Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression

    PubMed Central

    Jacobs, Evan S.; Abdel-Mohsen, Mohamed; Gibb, Stuart L.; Heitman, John W.; Inglis, Heather C.; Martin, Jeffrey N.; Zhang, Jinbing; Kaidarova, Zhanna; Deng, Xutao; Wu, Shiquan; Anastos, Kathryn; Crystal, Howard; Villacres, Maria C.; Young, Mary; Greenblatt, Ruth M.; Landay, Alan L.; Gange, Stephen J.; Deeks, Steven G.; Golub, Elizabeth T.; Pillai, Satish K.

    2017-01-01

    ABSTRACT A subset of HIV-infected individuals termed elite controllers (ECs) maintain CD4+ T cell counts and control viral replication in the absence of antiretroviral therapy (ART). Systemic cytokine responses may differentiate ECs from subjects with uncontrolled viral replication or from those who require ART to suppress viral replication. We measured 87 cytokines in four groups of women: 73 ECs, 42 with pharmacologically suppressed viremia (ART), 42 with uncontrolled viral replication (noncontrollers [NCs]), and 48 HIV-uninfected (NEG) subjects. Four cytokines were elevated in ECs but not NCs or ART subjects: CCL14, CCL21, CCL27, and XCL1. In addition, median stromal cell-derived factor-1 (SDF-1) levels were 43% higher in ECs than in NCs. The combination of the five cytokines suppressed R5 and X4 virus replication in resting CD4+ T cells, and individually SDF-1β, CCL14, and CCL27 suppressed R5 virus replication, while SDF-1β, CCL21, and CCL14 suppressed X4 virus replication. Functional studies revealed that the combination of the five cytokines upregulated CD69 and CCR5 and downregulated CXCR4 and CCR7 on CD4+ T cells. The CD69 and CXCR4 effects were driven by SDF-1, while CCL21 downregulated CCR7. The combination of the EC-associated cytokines induced expression of the anti-HIV host restriction factors IFITM1 and IFITM2 and suppressed expression of RNase L and SAMHD1. These results identify a set of cytokines that are elevated in ECs and define their effects on cellular activation, HIV coreceptor expression, and innate restriction factor expression. This cytokine pattern may be a signature characteristic of HIV-1 elite control, potentially important for HIV therapeutic and curative strategies. IMPORTANCE Approximately 1% of people infected with HIV control virus replication without taking antiviral medications. These subjects, termed elite controllers (ECs), are known to have stronger immune responses targeting HIV than the typical HIV-infected subject, but the exact mechanisms of how their immune responses control infection are not known. In this study, we identified five soluble immune signaling molecules (cytokines) in the blood that were higher in ECs than in subjects with typical chronic HIV infection. We demonstrated that these cytokines can activate CD4+ T cells, the target cells for HIV infection. Furthermore, these five EC-associated cytokines could change expression levels of intrinsic resistance factors, or molecules inside the target cell that fight HIV infection. This study is significant in that it identified cytokines elevated in subjects with a good immune response against HIV and defined potential mechanisms as to how these cytokines could induce resistance to the virus in target cells. PMID:28053103

  13. Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression.

    PubMed

    Jacobs, Evan S; Keating, Sheila M; Abdel-Mohsen, Mohamed; Gibb, Stuart L; Heitman, John W; Inglis, Heather C; Martin, Jeffrey N; Zhang, Jinbing; Kaidarova, Zhanna; Deng, Xutao; Wu, Shiquan; Anastos, Kathryn; Crystal, Howard; Villacres, Maria C; Young, Mary; Greenblatt, Ruth M; Landay, Alan L; Gange, Stephen J; Deeks, Steven G; Golub, Elizabeth T; Pillai, Satish K; Norris, Philip J

    2017-03-15

    A subset of HIV-infected individuals termed elite controllers (ECs) maintain CD4 + T cell counts and control viral replication in the absence of antiretroviral therapy (ART). Systemic cytokine responses may differentiate ECs from subjects with uncontrolled viral replication or from those who require ART to suppress viral replication. We measured 87 cytokines in four groups of women: 73 ECs, 42 with pharmacologically suppressed viremia (ART), 42 with uncontrolled viral replication (noncontrollers [NCs]), and 48 HIV-uninfected (NEG) subjects. Four cytokines were elevated in ECs but not NCs or ART subjects: CCL14, CCL21, CCL27, and XCL1. In addition, median stromal cell-derived factor-1 (SDF-1) levels were 43% higher in ECs than in NCs. The combination of the five cytokines suppressed R5 and X4 virus replication in resting CD4 + T cells, and individually SDF-1β, CCL14, and CCL27 suppressed R5 virus replication, while SDF-1β, CCL21, and CCL14 suppressed X4 virus replication. Functional studies revealed that the combination of the five cytokines upregulated CD69 and CCR5 and downregulated CXCR4 and CCR7 on CD4 + T cells. The CD69 and CXCR4 effects were driven by SDF-1, while CCL21 downregulated CCR7. The combination of the EC-associated cytokines induced expression of the anti-HIV host restriction factors IFITM1 and IFITM2 and suppressed expression of RNase L and SAMHD1. These results identify a set of cytokines that are elevated in ECs and define their effects on cellular activation, HIV coreceptor expression, and innate restriction factor expression. This cytokine pattern may be a signature characteristic of HIV-1 elite control, potentially important for HIV therapeutic and curative strategies. IMPORTANCE Approximately 1% of people infected with HIV control virus replication without taking antiviral medications. These subjects, termed elite controllers (ECs), are known to have stronger immune responses targeting HIV than the typical HIV-infected subject, but the exact mechanisms of how their immune responses control infection are not known. In this study, we identified five soluble immune signaling molecules (cytokines) in the blood that were higher in ECs than in subjects with typical chronic HIV infection. We demonstrated that these cytokines can activate CD4 + T cells, the target cells for HIV infection. Furthermore, these five EC-associated cytokines could change expression levels of intrinsic resistance factors, or molecules inside the target cell that fight HIV infection. This study is significant in that it identified cytokines elevated in subjects with a good immune response against HIV and defined potential mechanisms as to how these cytokines could induce resistance to the virus in target cells. Copyright © 2017 American Society for Microbiology.

  14. Effect of HIV/AIDS on the control environment.

    PubMed

    Coetzee, Philna

    2006-07-01

    The management of organizations is responsible for risk management and control systems. HIV/AIDS could be a great threat in the achievement of strategic business objectives, implicating a great concern for management. Management needs to understand this possible risk. This study aims to identify the effect that HIV/AIDS could have on the different elements of the control environment. The archival research method was used. It was established that no formal research was conducted to date on the effect of HIV/AIDS on the control environment as a whole. Various studies have included the effect of HIV/AIDS on certain factors of the control environment. These studies will be discussed briefly to identify relevant findings. The study indicated that the disease could affect various aspects of the control environment, namely: competency of the workforce (e.g. productivity, quality of work, absenteeism, loss of skills and knowledge, training and recruitment, etc.); organizational structure (e.g. increase use of technology labour, disruption of processes, level of employees affected by the disease); human resource (HR) policies and practices (e.g. legislation applicable, prevention and awareness programmes, compensation and benefits). Research limitation: HIV/AIDS is a relatively new potential risk to organizations. Knowledge of the disease is limited. HIV/AIDS is also a very sensitive issue as people fear the disease and do not like to discuss its existence. Government determined that it should be a non-notifiable disease and the disease is currently greatly stigmatized. The databases of companies investigated by other research studies were not developed to gather all the relevant information. Management should be aware that HIV/AIDS poses a possible risk to organizations. Data on the effect of HIV/AIDS should be gathered and used in the decision-making process on how to manage this risk. To be able to fulfil this duty, management first has to determine: whether HIV/AIDS is a risk; the relevant cost involved that the disease is costing the organization; how to control these costs.

  15. Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.

    PubMed

    Colby, Donn J; Trautmann, Lydie; Pinyakorn, Suteeraporn; Leyre, Louise; Pagliuzza, Amélie; Kroon, Eugène; Rolland, Morgane; Takata, Hiroshi; Buranapraditkun, Supranee; Intasan, Jintana; Chomchey, Nitiya; Muir, Roshell; Haddad, Elias K; Tovanabutra, Sodsai; Ubolyam, Sasiwimol; Bolton, Diane L; Fullmer, Brandie A; Gorelick, Robert J; Fox, Lawrence; Crowell, Trevor A; Trichavaroj, Rapee; O'Connell, Robert; Chomont, Nicolas; Kim, Jerome H; Michael, Nelson L; Robb, Merlin L; Phanuphak, Nittaya; Ananworanich, Jintanat

    2018-06-11

    Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.

  16. HIV and TB co-infection in Indian context.

    PubMed

    Mahyoub, E M; Garg, Suneela; Singh, M M; Agarwal, Paras; Gupta, V K; Gupta, Naresh

    2013-01-01

    This study was carried out in a Anti-Retroviral Therapy Clinic and TB center of a tertiary level hospital to find out socio-demographic correlates of HIV/TB individuals and risk factors of HIV/TB co-infection in Indian context. It is a case-control study comprising 420 subjects, 3 groups of 140 each. For a case group of HIV-TB co-infected subjects, two control groups, one comprising HIV patients (not having TB), and the other TB patients (not having HIV). Majority 267 (63.6%) males, 100 (71.4%) in case group (HIV/ TB), 74 (52.9%) in control group 1 (TB) and 93 (66.4%) in control group 2 (HIV). Mean (+/-SD) age of case-group was 34.91 (+/- 8.57) years. New TB cases were 213 (76.1%), more among control-group 1, compared to case-group. Multivariate analysis showed that risk of co-infection was 1.94 times higher among individuals aged >35 years. Difference statistically significant amongst those who were not on ART than who were on ART (p < 0.001). Those with CD4 counts <200 had 1.85 times risk of TB. Smokers had 1.92 times risk of TB. Co-infection higher in males, in age group 35-44 years, urban area, lower educational status and lower socioeconomic class. Current history of smoking significantly associated with co-infection. HIV status during TB infection was detected in 1/4th of study subjects. History of TB symptoms in family significantly associated with co-infection.

  17. Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype.

    PubMed

    Bhardwaj, Suvercha; Ahmad, Fareed; Wedemeyer, Heiner; Cornberg, Marcus; Schulze Zur Wiesch, Julian; van Lunzen, Jan; Sarin, Shiv K; Schmidt, Reinhold E; Meyer-Olson, Dirk

    2016-04-18

    HIV-HCV co-infection is associated with accelerated progression to hepatic fibrosis, cirrhosis and hepatocellular carcinoma than HCV mono-infection. The contribution of innate immunity during HIV-HCV co-infection has been a relatively under-investigated area. Natural killer (NK) cells are pivotal sentinels of innate immunity against viruses and tumour cells. In this study we evaluated the effect of HIV-HCV co-infection on peripheral blood NK cell subsets with emphasis on the phenotype of CD56(bright) NK cells. Sixty patients were included in the study; HIV mono-infected (n = 12), HCV mono-infected (n = 15), HCV-HIV co-infected (n = 21) and healthy controls (n = 16). PBMCs were isolated and immunophenotyping of NK cells was performed by flowcytometry. We observed an expansion of CD56(bright) NK cell subset in HIV-HCV co-infection as compared to healthy controls and HIV mono-infected group. All the infected groups had an upregulated expression of the activating receptor NKG2D on CD56(bright) NK cells in comparison to healthy controls while not differing amongst themselves. The expression of NKp46 in HIV-HCV co-infected group was significantly upregulated as compared to both HIV as well as HCV mono-infections while NKp30 expression in the HIV-HCV co-infected group significantly differed as compared to HIV mono-infection. The CD56(bright) NK cell subset was activated in HIV-HCV co-infection as assessed by the expression of CD69 as compared to healthy controls but was significantly downregulated in comparison to HIV mono-infection. CD95 expression on CD56(bright) NK cells followed the same pattern where there was an increased expression of CD95 in HIV mono-infection and HIV-HCV co-infection as compared to healthy controls. In contrast to CD69 expression, CD95 expression in HCV mono-infection was decreased when compared to HIV mono-infection and HIV-HCV co-infection. Finally, expression of CXCR3 on CD56(bright) NK cells was increased in HIV-HCV co-infection in comparison to HIV mono-infection while remaining similar to HCV mono-infection. Thus, HIV-HCV co-infection is able to modulate the phenotype of CD56(bright) NK cell subset in a unique way such that NKp46 and CXCR3 expressions are distinct for co-infection while both mono-infections have an additive effect on CD56(bright), CD69 with CD95 expressions. HCV mono-infection has a dominant effect on NKp30 expression while NKG2D and CD127 expressions remained same in all the groups.

  18. HIV knowledge, stigma, and illness beliefs among pediatric caregivers in Ghana who have not disclosed their child's HIV status.

    PubMed

    Paintsil, Elijah; Renner, Lorna; Antwi, Sampson; Dame, Joycelyn; Enimil, Anthony; Ofori-Atta, Angela; Alhassan, Amina; Ofori, Irene Pokuaa; Cong, Xiangyu; Kyriakides, Tassos; Reynolds, Nancy R

    2015-01-01

    The majority of HIV-infected children in sub-Saharan Africa have not been informed of their HIV status. Caregivers are reluctant to disclose HIV status to their children because of concern about the child's ability to understand, parental sense of guilt, and fear of social rejection and isolation. We hypothesized that the low prevalence of pediatric HIV disclosure in Ghana is due to lack of accurate HIV information and high HIV stigma among caregivers. This is a preliminary analysis of baseline data of an HIV pediatric disclosure intervention study in Ghana ("Sankofa"). "Sankofa" - is a two-arm randomized controlled clinical trial comparing disclosure intervention plus usual care (intervention arm) vs usual care (control arm) at Korle-Bu Teaching Hospital (KBTH; control arm) and Komfo-Anokye Teaching Hospital (KATH; intervention arm). We enrolled HIV-infected children, ages 7-18 years who do not know their HIV status, and their caregivers. Baseline data of caregivers included demographic characteristics; Brief HIV Knowledge Questionnaire (HIV-KQ-18); Brief Illness Perception Questionnaire; and HIV Stigma Scale. Simple and multivariable linear regression analyses were used to assess the relationship between caregiver characteristics and HIV knowledge, stigma, and illness perception. Two hundred and ninety-eight caregivers were enrolled between January 2013 and July 2014 at the two study sites; KBTH (n = 167) and KATH (n = 131). The median age of caregivers was 41 years; 80.5% of them were female and about 60% of caregivers were HIV-positive. Seventy-eight percent of caregivers were self-employed with low household income. In both unadjusted and adjusted analyses, HIV negative status and lower level of education were associated with poor scores on HIV-KQ. HIV positive status remained significant for higher level of stigma in the adjusted analyses. None of the caregiver's characteristics predicted caregiver's illness perception. Intensification of HIV education in schools and targeted community campaigns are needed.

  19. The microbiome and HIV persistence: implications for viral remission and cure.

    PubMed

    Koay, Wei Li A; Siems, Lilly V; Persaud, Deborah

    2018-01-01

    This article discusses the interaction between HIV infection, the gut microbiome, inflammation and immune activation, and HIV reservoirs, along with interventions to target the microbiome and their implications for HIV remission and cure. Most studies show that HIV-infected adults have a gut microbiome associated with decreased bacterial richness and diversity, and associated systemic inflammation and immune activation. A unique set of individuals, elite controllers, who spontaneously control HIV replication, have a similar microbiome to HIV-uninfected individuals. Conversely, exposure to maternal HIV in infants was shown to alter the gut microbiome, even in infants who escaped perinatal infection. Emerging research highlights the importance of the metabolomics and metaproteomics of the gut microbiome, which may have relevance for HIV remission and cure. Together, these studies illustrate the complexity of the relationship between HIV infection, the gut microbiome, and its systemic effects. Understanding the association of HIV with the microbiome, metabolome, and metaproteome may lead to novel therapies to decrease inflammation and immune activation, and impact HIV reservoir size and vaccine responses. Further research in this area is important to inform HIV remission and cure treatments.

  20. The impact of HIV infection and antiretroviral therapy on the predicted risk of Down syndrome.

    PubMed

    Charlton, Thomas G; Franklin, Jamie M; Douglas, Melanie; Short, Charlotte E; Mills, Ian; Smith, Rachel; Clarke, Amanda; Smith, John; Tookey, Pat A; Cortina-Borja, Mario; Taylor, Graham P

    2014-02-01

    The aim of this study was to assess predicted Down syndrome risk, based on three serum analytes (triple test), with HIV infection status and antiretroviral therapy regimen. Screening results in 72 HIV-positive women were compared with results from age-matched and race-matched HIV-negative controls. Mean concentrations of each analyte were compared by serostatus and antiretroviral therapy. Observed Down syndrome incidence in the offspring of HIV-positive women was calculated from national HIV surveillance data. Overall, women with HIV had a significantly higher probability of receiving a 'high-risk' result than uninfected controls (p = 0.002). Compared with matched uninfected controls, women with HIV infection had significantly higher human chorionic gonadotrophin, lower unconjugated estriol, and higher overall predicted risk of their infant having Down syndrome (1/6250 vs. 1/50 000 p = < 0.001). National surveillance data show no evidence of higher than expected incidence of Down syndrome in the offspring of HIV-positive women. HIV infection impacts the serum analytes used to assay for Down syndrome risk resulting in a high rate of 'high risk' results. However, there is no population-based association between maternal HIV infection and Down syndrome. Care should be taken when interpreting high-risk serum screening results in HIV-positive women to avoid unnecessary invasive diagnostic procedures. © 2013 John Wiley & Sons, Ltd.

  1. Subnormal and waning immunity to tetanus toxoid in previously vaccinated HIV-infected children and response to booster doses of the vaccine.

    PubMed

    Choudhury, Shahana A; Matin, Fazle

    2013-12-01

    Little is known regarding waning immunity to tetanus toxoid (TT) in HIV-infected children and the need for booster doses before the recommended interval of 5-10 years. Anti-tetanus antibodies were assessed by ELISA in 24 HIV-infected and 24 control children. A protective level (>0.1 IU/ml) of TT antibodies was observed in 62% of HIV-infected children and in 100% of controls. HIV-infected children with five doses had a significantly (p=0.01) lower prevalence of protective immunity compared to controls. Follow-up anti-TT antibody levels in nine HIV-infected children declined from 1.27 to 0.26 IU/ml, but levels did not decline in the seven controls; five of the seven (71%) children with a non-protective level of antibodies responded with a level>0.16 IU/ml following one booster dose of the vaccine. HIV-infected children may need TT boosters before the recommended 5-10 years. Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  2. 33 CFR 117.989 - Trinity River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Pacific Railroad bridges, mile 41.4 at Liberty, mile 54.8 at Kenefick, mile 117.3 at Goodrich, mile 181.8 at Riverside, and the Burlington Northern Santa Fe railroad bridge, mile 96.2 at Romayor, need not be...

  3. 33 CFR 117.989 - Trinity River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Pacific Railroad bridges, mile 41.4 at Liberty, mile 54.8 at Kenefick, mile 117.3 at Goodrich, mile 181.8 at Riverside, and the Burlington Northern Santa Fe railroad bridge, mile 96.2 at Romayor, need not be...

  4. 33 CFR 117.989 - Trinity River.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Pacific Railroad bridges, mile 41.4 at Liberty, mile 54.8 at Kenefick, mile 117.3 at Goodrich, mile 181.8 at Riverside, and the Burlington Northern Santa Fe railroad bridge, mile 96.2 at Romayor, need not be...

  5. 33 CFR 117.989 - Trinity River.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Pacific Railroad bridges, mile 41.4 at Liberty, mile 54.8 at Kenefick, mile 117.3 at Goodrich, mile 181.8 at Riverside, and the Burlington Northern Santa Fe railroad bridge, mile 96.2 at Romayor, need not be...

  6. 33 CFR 117.989 - Trinity River.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Pacific Railroad bridges, mile 41.4 at Liberty, mile 54.8 at Kenefick, mile 117.3 at Goodrich, mile 181.8 at Riverside, and the Burlington Northern Santa Fe railroad bridge, mile 96.2 at Romayor, need not be...

  7. 78 FR 69124 - Trinity Adaptive Management Working Group; Public Meeting and Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... Recommendation, Bylaw discussion, 2014 Flow Alternatives, Status of Klamath fall flow release, Mining issues...Point, or rich text file). Registered speakers who wish to expand on their oral statements, or those who...

  8. 36 CFR 7.91 - Whiskeytown Unit, Whiskeytown-Shasta-Trinity National Recreation Area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... marine toilets so constructed as to permit wastes to be discharged directly into the water shall have such facilities sealed to prevent discharge. (2) Chemical or other type marine toilets with approved...

  9. 36 CFR 7.91 - Whiskeytown Unit, Whiskeytown-Shasta-Trinity National Recreation Area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... marine toilets so constructed as to permit wastes to be discharged directly into the water shall have such facilities sealed to prevent discharge. (2) Chemical or other type marine toilets with approved...

  10. 75 FR 25197 - Shasta Trinity National Forest, South Fork Management Unit, California Salt Timber Harvest and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... use telecommunication devices for the deaf (TDD) may call the Federal Information Relay Service (FIRS..., Environmental Protection Information Center and Kiamath Forest Alliance. On February 5, 2010, Appeal Reviewing...

  11. Pakistan needs to speed up its human immunodeficiency virus control strategy to achieve targets in fast-track acquired immune deficiency syndrome response.

    PubMed

    Waheed, Yasir; Waheed, Hasnain

    2017-05-12

    In last fifteen years remarkable success in the fight against human immunodeficiency virus (HIV) is achieved globally. The number of HIV infections has decreased and the number of people on antiretroviral therapy is increased. This all is possible by strong political commitments and heavy investments in the fight against HIV. Pakistan is among few Asian countries in which HIV cases are increasing year by year since 1990. There are 94000 cases of HIV in Pakistan and only 14000 are registered with government. The main source of HIV infection in Pakistan is the use of contaminated injection equipment among people who inject drugs (PWID). The overall prevalence of HIV among PWID in Pakistan is 27.2%. There are five cities in Pakistan in which HIV prevalence is above 40% in PWIDs. In June 2016, United Nations political declaration on acquired immune deficiency syndrome (AIDS) provided a global mandate to fast-track the AIDS response over the next five years to achieve the targets in Sustainable Development Goals. To achieve the targets in fast-track AIDS response, the global leaders showed strong commitments to invest $ 26 billion per year by 2020. Pakistan needs to speed up its HIV control program. There is a dire need to locate all HIV positive people and enroll them in the treatment program. Pakistan also needs to calculate exact number of people living with HIV, increase HIV treatment centers and increase HIV awareness. Recently, Global Fund invested handsome money in the fight against HIV. Let's hope the country will have effective HIV control strategy to achieve the HIV elimination target by 2030.

  12. Development of a Faith-Based Stress Management Intervention in a Rural African American Community.

    PubMed

    Bryant, Keneshia; Moore, Todd; Willis, Nathaniel; Hadden, Kristie

    2015-01-01

    Faith-based mental health interventions developed and implemented using a community-based participatory research (CBPR) approach hold promise for reaching rural African Americans and addressing health disparities. To describe the development, challenges, and lessons learned from the Trinity Life Management, a faith-based stress management intervention in a rural African American faith community. The researchers used a CBPR approach by partnering with the African American faith community to develop a stress management intervention. Development strategies include working with key informants, focus groups, and a community advisory board (CAB). The community identified the key concepts that should be included in a stress management intervention. The faith-based "Trinity Life Management" stress management intervention was developed collaboratively by a CAB and an academic research team. The intervention includes stress management techniques that incorporate Biblical principles and information about the stress-distress-depression continuum.

  13. Daedalus in Dublin: A Physicist's Labyrinth

    NASA Astrophysics Data System (ADS)

    O'Connor, Thomas C.

    2014-03-01

    I describe some of the rich physical and natural-philosophy heritage of the urban center of the Irish capital Dublin (first tour) and its environs (second tour), in a two-part excursion that could take between two and eight hours in toto. In terms of history, both tours center around the nineteenth century. The first tour is located in and around Trinity College, and we encounter such personages as William Rowan Hamilton, George Fitzgerald, Ernest Walton, and Erwin Schrödinger, among others. Moving away from Trinity College, the second tour explores some of the periphery of the city. I describe the role of politics, money, and religion in shaping the emergence and development of scientific talent among the Irish people, and consequently the footprint left by physics in the city today, with its numerous sites and names that put Irish physics in an honorable place among the nations.

  14. Effectiveness of Workshop Style Teaching in Students' Learning of Introductory Electricity and Magnetism

    NASA Astrophysics Data System (ADS)

    Mehta, Nirav; Cheng, Kelvin

    2012-10-01

    We have developed an interactive workshop-style course for our introductory calculus-based physics sequence at Trinity University. Lecture is limited to approximately 15 min. at the beginning of class, and the remainder of the 50-min. class is devoted to inquiry-based activities and problem solving. So far, lab is done separately and we have not incorporated the lab component into the workshop model. We use the Brief Electricity and Magnetism Assessment (BEMA) to compare learning gains between the workshop and traditional lecture-based course for the Spring 2012 semester. Both the workshop and lecture courses shared the same inquiry-based lab component that involved pre-labs, prediction-observation and post-lab activities. Our BEMA results indicate statistically significant improvement in overall learning gains compared to the traditional course. We compare our workshop BEMA scores both to traditional lecture scores here at Trinity and to those from other institutions.

  15. [Analysis of HIV antibody positive cases in Peking University Hospital of Stomatology during 9 years].

    PubMed

    Ding, Jian-fen; Qiu, Juan; Shen, Shu-ming

    2016-02-01

    To investigate the prevalence and characteristics of HIV patients found in Peking University Hospital of Stomatology during 9 years, and provide management strategy for early diagnosis and control of HIV in Stomatology Hospital. A retrospective study of the HIV positive patients diagnosed by HIV antibody screening was carried out. The related information about these patients found in Peking University School of Stomatology during 2005-2013 was obtained from China Disease Control Information System. 68,562 patients accepted HIV antibody screening in Peking University Hospital of Stomatology during 2005-2013. Thirty one patients were found HIV antibody positive. The ratio of HIV antibody positive was about 0.045%, which was composed of 25 males and 6 females. 61.29% patients aged between 20-40 years, and their career was mainly commercial service with a education level of junior high school. The proportion of sexual route of transmission was about 74.91%, and 34.78% of them were male homosexuality. Most of the patients with HIV antibody positive were found in the out-patient clinic, especially in the department of oral mucosal diseases, accounting for 70.97%. HIV antibody positive rate in Peking University School of Stomatology was slightly lower than that in general hospitals. Medical staff should increase their awareness of AIDS prevention and control, for higher HIV risk departments, such as oral mucosal diseases and periodontal disease, efforts should be made to increase HIV screening, expand the scope of screening, and promote provider-initiated HIV testing and counseling.

  16. Health Insurance Type and Control of Hypertension Among US Women Living With and Without HIV Infection in the Women's Interagency HIV Study.

    PubMed

    Ludema, Christina; Cole, Stephen R; Eron, Joseph J; Holmes, G Mark; Anastos, Kathryn; Cocohoba, Jennifer; Cohen, Marge H; Cooper, Hannah L F; Golub, Elizabeth T; Kassaye, Seble; Konkle-Parker, Deborah; Metsch, Lisa; Milam, Joel; Wilson, Tracey E; Adimora, Adaora A

    2017-06-01

    Health care access is an important determinant of health. We assessed the effect of health insurance status and type on blood pressure control among US women living with (WLWH) and without HIV. We used longitudinal cohort data from the Women's Interagency HIV Study (WIHS). WIHS participants were included at their first study visit since 2001 with incident uncontrolled blood pressure (BP) (i.e., BP ≥140/90 and at which BP at the prior visit was controlled (i.e., <135/85). We assessed time to regained BP control using inverse Kaplan-Meier curves and Cox proportional hazard models. Confounding and selection bias were accounted for using inverse probability-of-exposure-and-censoring weights. Most of the 1,130 WLWH and 422 HIV-uninfected WIHS participants who had an elevated systolic or diastolic measurement were insured via Medicaid, were African-American, and had a yearly income ≤$12,000. Among participants living with HIV, comparing the uninsured to those with Medicaid yielded an 18-month BP control risk difference of 0.16 (95% CI: 0.10, 0.23). This translates into a number-needed-to-treat (or insure) of 6; to reduce the caseload of WLWH with uncontrolled BP by one case, five individuals without insurance would need to be insured via Medicaid. Blood pressure control was similar among WLWH with private insurance and Medicaid. There were no differences observed by health insurance status on 18-month risk of BP control among the HIV-uninfected participants. These results underscore the importance of health insurance for hypertension control-especially for people living with HIV. © American Journal of Hypertension, Ltd 2017. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  17. Hepatic Enzyme Alterations in HIV Patients on Antiretroviral Therapy: A Case-Control Study in a Hospital Setting in Ghana.

    PubMed

    Osakunor, Derick Nii Mensah; Obirikorang, Christian; Fianu, Vincent; Asare, Isaac; Dakorah, Mavis

    2015-01-01

    Diagnosing hepatic injury in HIV infection can be a herculean task for clinicians as several factors may be involved. In this study, we sought to determine the effects of antiretroviral therapy (ART) and disease progression on hepatic enzymes in HIV patients. A case-control study conducted from January to May 2014 at the Akwatia Government Hospital, Eastern region, Ghana, The study included 209 HIV patients on ART (designated HIV-ART) and 132 ART-naive HIV patients (designated HIV-Controls). Data gathered included demography, clinical history and results of blood tests for hepatic enzymes. We employed the Fisher's, Chi-square, unpaired t-test and Pearson's correlation in analysis, using GraphPad Prism and SPSS. A P value < 0.05 was considered significant. Median CD4 lymphocyte count of HIV-ART participants (604.00 cells/mm3) was higher than that of HIV-Controls (491.50 cells/mm3; P = 0.0005). Mean values of ALP, ALT, AST and GGT did not differ between the two groups compared (P > 0.05). There was a significant positive correlation between hepatic enzymes (ALP, ALT, AST and GGT) for both groups (p < 0.01 each). Duration of ART correlated positively with ALT (p < 0.05). The effect size of disease progression on hepatic enzymes for both groups was small. Antiretroviral therapy amongst this population has minimal effects on hepatic enzymes and does not suggest modifications in therapy. Hepatic injury may occur in HIV, even in the absence of ART and other traditional factors. Monitoring of hepatic enzymes is still important in HIV patients.

  18. Glucose Metabolism Disorders, HIV and Antiretroviral Therapy among Tanzanian Adults

    PubMed Central

    Maganga, Emmanuel; Smart, Luke R.; Kalluvya, Samuel; Kataraihya, Johannes B.; Saleh, Ahmed M.; Obeid, Lama; Downs, Jennifer A.; Fitzgerald, Daniel W.; Peck, Robert N.

    2015-01-01

    Introduction Millions of HIV-infected Africans are living longer due to long-term antiretroviral therapy (ART), yet little is known about glucose metabolism disorders in this group. We aimed to compare the prevalence of glucose metabolism disorders among HIV-infected adults on long-term ART to ART-naïve adults and HIV-negative controls, hypothesizing that the odds of glucose metabolism disorders would be 2-fold greater even after adjusting for possible confounders. Methods In this cross-sectional study conducted between October 2012 and April 2013, consecutive adults (>18 years) attending an HIV clinic in Tanzania were enrolled in 3 groups: 153 HIV-negative controls, 151 HIV-infected, ART-naïve, and 150 HIV-infected on ART for ≥ 2 years. The primary outcome was the prevalence of glucose metabolism disorders as determined by oral glucose tolerance testing. We compared glucose metabolism disorder prevalence between each HIV group vs. the control group by Fisher’s exact test and used multivariable logistic regression to determine factors associated with glucose metabolism disorders. Results HIV-infected adults on ART had a higher prevalence of glucose metabolism disorders (49/150 (32.7%) vs.11/153 (7.2%), p<0.001) and frank diabetes mellitus (27/150 (18.0%) vs. 8/153 (5.2%), p = 0.001) than HIV-negative adults, which remained highly significant even after adjusting for age, gender, adiposity and socioeconomic status (OR = 5.72 (2.78–11.77), p<0.001). Glucose metabolism disorders were significantly associated with higher CD4+ T-cell counts. Awareness of diabetes mellitus was <25%. Conclusions HIV-infected adults on long-term ART had 5-fold greater odds of glucose metabolism disorders than HIV-negative controls but were rarely aware of their diagnosis. Intensive glucose metabolism disorder screening and education are needed in HIV clinics in sub-Saharan Africa. Further research should determine how glucose metabolism disorders might be related to immune reconstitution. PMID:26287742

  19. Antibody-Based Preventive and Therapeutic Strategies Against HIV.

    PubMed

    Fabra-Garcia, Amanda; Beltran, Carolina; Sanchez-Merino, Victor; Yuste, Eloisa

    2016-01-01

    Over the years, numerous studies have been carried out demonstrating the role of antibodies in HIV control leading to the development of antibody-based therapeutic and prophylactic strategies. The objective of this review is to provide updated information on the role of antibodies in the prevention and control of HIV infection and the strategies against HIV that have been designed based on this information. Passive transfer of anti-HIV antibodies in animal models has proven the efficacy of certain antibodies in the prevention and treatment of infection. The capacity of antibodies to control the virus was first attributed to their neutralizing capacity. However, we now know that there are other Fc-mediated antibody activities associated with virus protection. When it comes to better understanding protection against HIV, we ought to pay particular attention to mucosal immune responses. The evidence accumulated so far indicates that an effective vaccine against HIV should generate both mucosal IgAs and systemic IgGs. Due to the problematic induction of protective anti-HIV antibodies, several groups have developed alternative approaches based on antibody delivery via gene therapy vectors. Experiments in animal models with these vectors have shown impressive protection levels and this strategy is now being clinically trialed. Taking into account all the information included in this review, it seems evident that anti-HIV-1 antibodies play an important role in virus control and prevention. This review aims to give an overview of the strategies used and the advances in antibody-based preventive and therapeutic strategies against HIV-1.

  20. Unmatched Case-Control Study on Late Presentation of HIV Infection in Santiago, Cape Verde (2004–2011)

    PubMed Central

    Moreira, António L.; Fronteira, Inês; Augusto, Gonçalo Figueiredo; Martins, Maria Rosario O.

    2016-01-01

    Access to free antiretroviral therapy (ART) in Sub-Saharan Africa has been steadily increasing over the past decade. However, the success of large-scale ART programmes depends on timely diagnosis and early initiation of HIV care. This study characterizes late presenters to HIV care in Santiago (Cape Verde) between 2004 and 2011, and identifies factors associated with late presentation for care. We defined late presentation as persons presenting to HIV care with a CD4 count below 350 cells/mm3. An unmatched case-control study was conducted using socio-demographic and behavioural data of 368 individuals (191 cases and 177 controls) collected through an interviewer-administered questionnaire, comparing HIV patients late and early presented to care. Logistic regression was performed to estimate odds ratio and 95% confidence intervals. Results show that 51.9% were late presenters for HIV. No differences were found in gender distribution, marital status, or access to health services between cases and controls. Participants who undertook an HIV test by doctor indication were more likely to present late compared with those who tested for HIV by their own initiative. Also, individuals taking less time to initiate ART are more likely to present late. This study highlights the need to better understand reasons for late presentation to HIV care in Cape Verde. People in older age groups should be targeted in future approaches focused on late presenters to HIV care. PMID:26999167

  1. Unmatched Case-Control Study on Late Presentation of HIV Infection in Santiago, Cape Verde (2004-2011).

    PubMed

    Moreira, António L; Fronteira, Inês; Augusto, Gonçalo Figueiredo; Martins, Maria Rosario O

    2016-03-15

    Access to free antiretroviral therapy (ART) in Sub-Saharan Africa has been steadily increasing over the past decade. However, the success of large-scale ART programmes depends on timely diagnosis and early initiation of HIV care. This study characterizes late presenters to HIV care in Santiago (Cape Verde) between 2004 and 2011, and identifies factors associated with late presentation for care. We defined late presentation as persons presenting to HIV care with a CD4 count below 350 cells/mm³. An unmatched case-control study was conducted using socio-demographic and behavioural data of 368 individuals (191 cases and 177 controls) collected through an interviewer-administered questionnaire, comparing HIV patients late and early presented to care. Logistic regression was performed to estimate odds ratio and 95% confidence intervals. Results show that 51.9% were late presenters for HIV. No differences were found in gender distribution, marital status, or access to health services between cases and controls. Participants who undertook an HIV test by doctor indication were more likely to present late compared with those who tested for HIV by their own initiative. Also, individuals taking less time to initiate ART are more likely to present late. This study highlights the need to better understand reasons for late presentation to HIV care in Cape Verde. People in older age groups should be targeted in future approaches focused on late presenters to HIV care.

  2. Impact of HLA-DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort.

    PubMed

    Oriol-Tordera, B; Llano, A; Ganoza, C; Cate, S; Hildebrand, W; Sanchez, J; Calle, M L; Brander, C; Olvera, A

    2017-10-01

    Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Racial Disparities in HIV Care Extend to Common Comorbidities: Implications for Implementation of Interventions to Reduce Disparities in HIV Care.

    PubMed

    Richardson, Kelly K; Bokhour, Barbara; McInnes, D Keith; Yakovchenko, Vera; Okwara, Leonore; Midboe, Amanda M; Skolnik, Avy; Vaughan-Sarrazin, Mary; Asch, Steven M; Gifford, Allen L; Ohl, Michael E

    2016-01-01

    Prior studies have described racial disparities in the quality of care for persons with HIV infection, but it is unknown if these disparities extend to common comorbid conditions. To inform implementation of interventions to reduce disparities in HIV care, we examined racial variation in a set of quality measures for common comorbid conditions among Veterans in care for HIV in the United States. The cohort included 23,974 Veterans in care for HIV in 2013 (53.4% black; 46.6% white). Measures extracted from electronic health record and administrative data were receipt of combination antiretroviral therapy (cART), HIV viral control (serum RNA < 200 copies/ml among those on cART), hypertension control (blood pressure < 140/90 mm Hg among those with hypertension), diabetes control (hemoglobin A1C < 9% among those with diabetes), lipid monitoring, guideline-concordant antidepressant prescribing, and initiation and engagement in substance use disorder (SUD) treatment. Black persons were less likely than their white counterparts to receive cART (90.2% vs. 93.2%, p<.001), and experience viral control (84.6% vs. 91.3%, p<.001), hypertension control (61.9% vs. 68.3%, p<.001), diabetes control (85.5% vs. 89.5%, p<.001), and lipid monitoring (81.5% vs. 85.2%, p<.001). Initiation and engagement in SUD treatment were similar among blacks and whites. Differences remained after adjusting for age, comorbidity, retention in HIV care, and a measure of neighborhood social disadvantage created from census data. Implementation of interventions to reduce racial disparities in HIV care should comprehensively address and monitor processes and outcomes of care for key comorbidities. Published by Elsevier Inc.

  4. Undernutrition and anaemia among HAART-naïve HIV infected children in Ile-Ife, Nigeria: a case-controlled, hospital based study.

    PubMed

    Anyabolu, Henry Chineme; Adejuyigbe, Ebunoluwa Aderonke; Adeodu, Oluwagbemiga Oyewole

    2014-01-01

    Case control studies that assess the burden and factors associated with undernutrition and anaemia among HAART naïve HIV infected children in Nigeria is very sparse. This will help to formulate nutritional programs among these children. Seventy HAART naive HIV infected children aged 18 months and above were as well as seventy age and sex matched HIV negative children were recruited from August 2007 to January 2009 at Paediatric Clinic of Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria. Their bio data, WHO clinical stage, anthropometric measurements, haematocrit, serum albumin and CD4 counts were taken with other parameters according to a study proforma. The prevalence of stunting, underweight and wasting among the HIV infected subjects were 48. 6%,58. 6% and 31. 4% respectively which as significantly higher than 28. 1%, 7. 1% and 28. 1% among the HIV negative controls. 20. 1% of the HIV infected children were marasmic compared to 2. 3% of the controls. Triple anthropometric failure was found in 7. 1% of the subjects as compared to none among the controls. Anaemia is significantly more prevalent among the subjects than the controls (70. 0% vs 31. 4%; p<0. 001). The prevalence of anaemia was higher in the HIV infected subjects with undernutrition. Low socioeconomic status, hypoalbuminemia and severe immunosuppression are significantly associated with higher undernutrition prevalence. Several years after availability of HAART, undernutrition and anaemia remain widely prevalent among newly presenting HAART naïve HIV infected Nigerian children. Nutritional supplementation and evaluation for anaemia still need close attention in the management of these children.

  5. MHC-driven HIV-1 control on the long run is not systematically determined at early times post-HIV-1 infection.

    PubMed

    Antoni, Guillemette; Guergnon, Julien; Meaudre, Céline; Samri, Assia; Boufassa, Faroudy; Goujard, Cécile; Lambotte, Olivier; Autran, Brigitte; Rouzioux, Christine; Costagliola, Dominique; Meyer, Laurence; Theodorou, Ioannis

    2013-07-17

    Human leukocyte antigen (HLA) class I-driven long-term protection against HIV-1 is mainly associated with HLA-B*27 and HLA-B*57. This effect is observed early after infection. Clarification needs to be established concerning the moment of action for the other HLA-B or HLA-C alleles. HLA-B and HLA-C alleles from 111 individuals that control HIV-1 disease for over 8 years and from 747 seroconverters frequencies were compared. Also, HLA-B and HLA-C influence on early levels of plasma HIV-RNA, cellular HIV-DNA, CD4, CD8 and CD4/CD8 ratio was evaluated among the seroconverters. We performed univariate, multivariate and haplotypic analyses in order to disentangle the respective contribution of the HLA-B and HLA-C genes. The haplotypes analysis shows three patterns of protective effects of HLA-B and HLA-C alleles or haplotypes. First, the HLA B*57, HLA-B*27, HLA-B*13 and HLA-C*14 alleles, which have a strong effect on long-term disease control, also influence at least one of the early infection phenotypes. Second, HLA-B*52 has a strong effect during early time points on HIV-RNA without significant effect on the long-term control of HIV-1. Finally, the HLA-B*14-C*08 haplotype has a strong effect on the long-term protection, without influencing early viral control. Our study highlighted independent effects of HLA-B and HLA-C alleles on HIV-disease progression. Furthermore, some alleles appeared to be specifically associated with either long-term control or early virological parameters, suggesting different immunological mechanisms according to the disease stages.

  6. Mental health among adolescents living with HIV in Namibia: the role of poverty, orphanhood and social support.

    PubMed

    Gentz, Shelene G; Calonge-Romano, Isabel; Martínez-Arias, Rosario; Zeng, Chengbo; Ruiz-Casares, Mónica

    2018-05-30

    The mental health needs of children and adolescents living with HIV (ALHIV) in Namibia are poorly understood, despite the dramatic improvement in their survival. ALHIV in resource poor contexts face particular risk factors, such as poverty, orphanhood, and poor social support. This study examines the mental health of ALHIV in Namibia, and the factors that contribute to mental health problems. A case-control design assessed emotional and behavioural symptoms of distress, risk and protective factors among adolescents aged 12-18 years. Case participants were 99 HIV-positive adolescents. Case controls were 159 adolescents from the same community who were not known to be HIV seropositive at the time of the study. Control group participants were selected from schools using a stratified random sampling. A larger proportion of HIV-positive adolescents were orphaned (62.6% vs. 20.8%, p < .001); the groups showed no differences in poverty factors. HIV-positive adolescents scored lower than the control group on total perceived social support (p < .05) and caregiver support (p < .05), but no differences in perceived friend support and support from a self-selected person were present. HIV-positive adolescents reported significantly more total emotional and behavioural difficulties (p = .027) and conduct problems (p = .025), even after controlling for socio-demographic factors. However, after controlling for the effects of orphanhood, group differences in mental health outcomes were no longer significant. Furthermore, mediation analysis suggested that social support completely mediated the relationship between HIV status and mental health (standardised pathway coefficients = .05, p = .021). Policies and programmes that aim to strengthen social support and take orphanhood status into consideration may improve the mental health of adolescents living with HIV.

  7. Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging–measured adipose tissue depots in both HIV-infected and control subjects2

    PubMed Central

    Scherzer, Rebecca; Shen, Wei; Bacchetti, Peter; Kotler, Donald; Lewis, Cora E; Shlipak, Michael G; Heymsfield, Steven B

    2008-01-01

    Background Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects. Objective We compared anthropometric and magnetic resonance imaging (MRI)–based adiposity measures as correlates of metabolic complications of adiposity in HIV-infected and control subjects. Design The study was a cross-sectional analysis of 666 HIV-positive and 242 control subjects in the Fat Redistribution and Metabolic Change in HIV Infection (FRAM) study assessing body mass index (BMI), waist (WC) and hip (HC) circumferences, waist-to-hip ratio (WHR), %BF, and MRI-measured regional adipose tissue. Study outcomes were 3 metabolic risk variables [homeostatic model assessment (HOMA), triglycerides, and HDL cholesterol]. Analyses were stratified by sex and HIV status and adjusted for demographic, lifestyle, and HIV-related factors. Results In HIV-infected and control subjects, univariate associations with HOMA, triglycerides, and HDL were strongest for WC, MRI-measured visceral adipose tissue, and WHR; in all cases, differences in correlation between the strongest measures for each outcome were small (r ≤ 0.07). Multivariate adjustment found no significant difference for optimally fitting models between the use of anthropometric and MRI measures, and the magnitudes of differences were small (adjusted R2 ≤ 0.06). For HOMA and HDL, WC appeared to be the best anthropometric correlate of metabolic complications, whereas, for triglycerides, the best was WHR. Conclusion Relations of simple anthropometric measures with HOMA, triglycerides, and HDL cholesterol are approximately as strong as MRI-measured whole-body adipose tissue depots in both HIV-infected and control subjects. PMID:18541572

  8. Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects.

    PubMed

    Scherzer, Rebecca; Shen, Wei; Bacchetti, Peter; Kotler, Donald; Lewis, Cora E; Shlipak, Michael G; Heymsfield, Steven B; Grunfeld, Carl

    2008-06-01

    Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects. We compared anthropometric and magnetic resonance imaging (MRI)-based adiposity measures as correlates of metabolic complications of adiposity in HIV-infected and control subjects. The study was a cross-sectional analysis of 666 HIV-positive and 242 control subjects in the Fat Redistribution and Metabolic Change in HIV Infection (FRAM) study assessing body mass index (BMI), waist (WC) and hip (HC) circumferences, waist-to-hip ratio (WHR), %BF, and MRI-measured regional adipose tissue. Study outcomes were 3 metabolic risk variables [homeostatic model assessment (HOMA), triglycerides, and HDL cholesterol]. Analyses were stratified by sex and HIV status and adjusted for demographic, lifestyle, and HIV-related factors. In HIV-infected and control subjects, univariate associations with HOMA, triglycerides, and HDL were strongest for WC, MRI-measured visceral adipose tissue, and WHR; in all cases, differences in correlation between the strongest measures for each outcome were small (r

  9. A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

    PubMed Central

    Date, Abhijit A.; Destache, Christopher J.

    2013-01-01

    Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis. PMID:23726227

  10. Using Facebook as a Platform to Direct Young Black Men Who Have Sex With Men to a Video-Based HIV Testing Intervention: A Feasibility Study.

    PubMed

    Washington, Thomas Alex; Applewhite, Sheldon; Glenn, Wendell

    2017-01-01

    A randomized control pilot study was conducted with Black men who have sex with men (BMSM; N = 42) aged 18-30 years to examine the feasibility of implementing a video intervention delivered using Facebook to motivate HIV testing. At baseline, participants were unaware of their HIV status and had not tested for HIV in the past 6 months, residing in Los Angeles County. The intervention content included topics such as social influence, HIV knowledge, stigma, HIV positive knowledge, and benefits of knowing one's HIV status. Logistic regression revealed that those receiving the video intervention were 7 times more likely to have tested for HIV than those in the control group at 6-week follow-up (odds ratio [ OR ] = 7.00, 95% confidence interval [1.72, 28.33], p = .006). Data suggest that the intervention was feasible for motivating HIV testing.

  11. A Review of the Centers for Disease Control and Prevention's Response to the HIV/AIDS Crisis Among Blacks in the United States, 1981–2009

    PubMed Central

    Jones, Rhondette L.; Wolitski, Richard J.; Cleveland, Janet C.; Dean, Hazel D.; Fenton, Kevin A.

    2009-01-01

    Among US racial/ethnic groups, Blacks are at the highest risk of acquiring HIV/AIDS. In response, the Centers for Disease Control and Prevention (CDC) has launched the Heightened National Response to Address the HIV/AIDS Crisis Among African Americans, which seeks to engage public and nonpublic partners in a synergistic effort to prevent HIV among Blacks. The CDC also recently launched Act Against AIDS, a campaign to refocus attention on the domestic HIV/AIDS crisis. Although the CDC's efforts to combat HIV/AIDS among Blacks have achieved some success, more must be done to address this crisis. New initiatives include President Obama's goal of developing a National HIV/AIDS Strategy to reduce HIV incidence, decrease HIV-related health disparities, and increase access to care, especially among Blacks and other disproportionately affected populations. PMID:19797748

  12. Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment.

    PubMed

    Wiesman, Alex I; O'Neill, Jennifer; Mills, Mackenzie S; Robertson, Kevin R; Fox, Howard S; Swindells, Susan; Wilson, Tony W

    2018-06-01

    Combination antiretroviral therapies have revolutionized the treatment of HIV infection, and many patients now enjoy a lifespan equal to that of the general population. However, HIV-associated neurocognitive disorders (HAND) remain a major health concern, with between 30% and 70% of all HIV-infected patients developing cognitive impairments during their life time. One important feature of HAND is visuo-perceptual deficits, but the systems-level neural dynamics underlying these impairments are poorly understood. In the current study, we use magnetoencephalography and advanced time series analyses to examine these neural dynamics during a visuospatial processing task in a group of HIV-infected patients without HAND (n = 25), patients with HAND (n = 18), and a group of demographically-matched uninfected controls (n = 24). All participants completed a thorough neuropsychological assessment, and underwent magnetoencephalography and structural MRI protocols. In agreement with previous studies, patients with HAND performed significantly worse than HIV-infected patients without HAND and controls on the cognitive task, in terms of increased reaction time and decreased accuracy. Our magnetoencephalography results demonstrated that both spontaneous and neural oscillatory activity within the occipital cortices were affected by HIV infection, and that these patterns predicted behavioural performance (i.e. accuracy) on the task. Specifically, spontaneous neural activity in the alpha (8-16 Hz) and gamma (52-70 Hz) bands during the prestimulus baseline period, as well as oscillatory theta responses (4-8 Hz) during task performance were aberrant in HIV-infected patients, with both spontaneous alpha and oscillatory theta activity significantly predicting accuracy on the task and neuropsychological performance outside of the magnetoencephalography scanner. Importantly, these rhythmic patterns of population-level neural activity also distinguished patients by HAND status, such that spontaneous alpha activity in patients with HAND was elevated relative to HIV-infected patients without HAND and controls. In contrast, HIV-infected patients with and without HAND had increased spontaneous gamma compared to controls. Finally, there was a stepwise decrease in oscillatory theta activity as a function of disease severity, such that the response diminished from controls to patients without HAND to patients with HAND. Interestingly, the strength of the relationship between this theta response and accuracy also dissociated patient groups in a similar manner (controls > HIV with no HAND > HIV with HAND), indicating a reduced coupling between neurophysiology and behaviour in HIV-infected patients. This study provides the first neuroimaging evidence of a dissociation between HIV-infected patients with and without HAND, and these findings shed new light on the neural bases of cognitive impairment in HIV infection.

  13. Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity

    PubMed Central

    2017-01-01

    ABSTRACT HLA-C expression is associated with a differential ability to control HIV-1 infection. Higher HLA-C levels may lead to better control of HIV-1 infection through both a higher efficiency of antigen presentation to cytotoxic T lymphocytes and the triggering of activating killer immunoglobulin-like receptors on NK cells, whereas lower levels may provide poor HIV-1 control and rapid progression to AIDS. We characterized the relative amounts of HLA-C heterotrimers (heavy chain/β2 microglobulin [β2m]/peptide) and HLA-C free heavy chains on peripheral blood mononuclear cells (PBMCs) from healthy blood donors harboring both alleles with stable or unstable binding to β2m/peptide. We analyzed the stability of HLA-C heterotrimers of different allotypes and the infectivity of HIV-1 virions produced by PBMCs with various allotypes. We observed significant differences in HLA-C heterotrimer stability and in expression levels. We found that R5 HIV-1 virions produced by PBMCs harboring unstable HLA-C alleles were more infectious than those produced by PBMCs carrying the stable variants. We propose that HIV-1 infectivity might depend both on the amounts of HLA-C molecules and on their stability as trimeric complex. According to this model, individuals with low-expression HLA-C alleles and unstable binding to β2m/peptide might have worse control of HIV-1 infection and an intrinsically higher capacity to support viral replication. IMPORTANCE Following HIV-1 infection, some people advance rapidly to AIDS while others have slow disease progression. HLA-C, a molecule involved in immunity, is a key determinant of HIV-1 control. Here we reveal how HLA-C variants contribute to the modulation of viral infectivity. HLA-C is present on the cell surface in two different conformations. The immunologically active conformation is part of a complex that includes β2 microglobulin/peptide; the other conformation is not bound to β2 microglobulin/peptide and can associate with HIV-1, increasing its infectivity. Individuals with HLA-C variants with a predominance of immunologically active conformations would display stronger immunity to HIV-1, reduced viral infectivity and effective control of HIV-1 infection, while subjects with HLA-C variants that easily dissociate from β2 microglobulin/peptide would have a reduced immunological response to HIV-1 and produce more infectious virions. This study provides new information that could be useful in the design of novel vaccine strategies and therapeutic approaches to HIV-1. PMID:29070683

  14. The Theory of Planned Behavior as a Predictor of HIV Testing Intention.

    PubMed

    Ayodele, Olabode

    2017-03-01

    This investigation tests the theory of planned behavior (TPB) as a predictor of HIV testing intention among Nigerian university undergraduate students. A cross-sectional study of 392 students was conducted using a self-administered structured questionnaire that measured socio-demographics, perceived risk of human immunodeficiency virus (HIV) infection, and TPB constructs. Analysis was based on 273 students who had never been tested for HIV. Hierarchical multiple regression analysis assessed the applicability of the TPB in predicting HIV testing intention and additional predictive value of perceived risk of HIV infection. The prediction model containing TPB constructs explained 35% of the variance in HIV testing intention, with attitude and perceived behavioral control making significant and unique contributions to intention. Perceived risk of HIV infection contributed marginally (2%) but significantly to the final prediction model. Findings supported the TPB in predicting HIV testing intention. Although future studies must determine the generalizability of these results, the findings highlight the importance of perceived behavioral control, attitude, and perceived risk of HIV infection in the prediction of HIV testing intention among students who have not previously tested for HIV.

  15. HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response

    PubMed Central

    Abdool Karim, Salim S.; Churchyard, Gavin J.; Abdool Karim, Quarraisha; Lawn, Stephen D.

    2009-01-01

    One of the greatest challenges facing post-apartheid South Africa is the control of the concomitant HIV and tuberculosis epidemics. HIV continues to spread relentlessly, and tuberculosis has been declared a national emergency. In 2007, South Africa, with 0·7% of the world’s population, had 17% of the global burden of HIV infection, and one of the world’s worst tuberculosis epidemics, compounded by rising drug resistance and HIV co-infection. Until recently, the South African Government’s response to these diseases has been marked by denial, lack of political will, and poor implementation of policies and programmes. Nonetheless, there have been notable achievements in disease management, including substantial improvements in access to condoms, expansion of tuberculosis control efforts, and scale-up of free antiretroviral therapy (ART). Care for acutely ill AIDS patients and long-term provision of ART are two issues that dominate medical practice and the health-care system. Decisive action is needed to implement evidence-based priorities for the control of the HIV and tuberculosis epidemics. By use of the framework of the Strategic Plans for South Africa for tuberculosis and HIV/AIDS, we provide prioritised four-step approaches for tuberculosis control, HIV prevention, and HIV treatment. Strong leadership, political will, social mobilisation, adequate human and financial resources, and sustainable development of health-care services are needed for successful implementation of these approaches. PMID:19709731

  16. A Controlled Study of Funding for Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome as Resource Capacity Building in the Health System in Rwanda

    PubMed Central

    Shepard, Donald S.; Zeng, Wu; Amico, Peter; Rwiyereka, Angelique K.; Avila-Figueroa, Carlos

    2012-01-01

    Because human inmmunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) receives more donor funding globally than that for all other diseases combined, some critics allege this support undermines general health care. This empirical study evaluates the impact of HIV/AIDS funding on the primary health care system in Rwanda. Using a quasi-experimental design, we randomly selected 25 rural health centers (HCs) that started comprehensive HIV/AIDS services from 2002 through 2006 as the intervention group. Matched HCs with no HIV/AIDS services formed the control group. The analysis compared growth in inputs and services between intervention and control HCs with a difference-in-difference analysis in a random-effects model. Intervention HCs performed better than control HCs in most services (seven of nine), although only one of these improvements (Bacille Calmette-Guérin vaccination) reached or approached statistical significance. In conclusion, this six-year controlled study found no adverse effects of the expansion of HIV/AIDS services on non-HIV services among rural health centers in Rwanda. PMID:22556094

  17. A controlled study of funding for human immunodeficiency virus/acquired immunodeficiency syndrome as resource capacity building in the health system in Rwanda.

    PubMed

    Shepard, Donald S; Zeng, Wu; Amico, Peter; Rwiyereka, Angelique K; Avila-Figueroa, Carlos

    2012-05-01

    Because human inmmunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) receives more donor funding globally than that for all other diseases combined, some critics allege this support undermines general health care. This empirical study evaluates the impact of HIV/AIDS funding on the primary health care system in Rwanda. Using a quasi-experimental design, we randomly selected 25 rural health centers (HCs) that started comprehensive HIV/AIDS services from 2002 through 2006 as the intervention group. Matched HCs with no HIV/AIDS services formed the control group. The analysis compared growth in inputs and services between intervention and control HCs with a difference-in-difference analysis in a random-effects model. Intervention HCs performed better than control HCs in most services (seven of nine), although only one of these improvements (Bacille Calmette-Guérin vaccination) reached or approached statistical significance. In conclusion, this six-year controlled study found no adverse effects of the expansion of HIV/AIDS services on non-HIV services among rural health centers in Rwanda.

  18. Reservoir Control Center: Activities and Accomplishments of the Southwestern Division of the Army Corps of Engineers Related to Reservoir Regulation and Water Management. Part 3. Instream Flow Study. Appendix A.

    DTIC Science & Technology

    1981-01-01

    Inoduction I.. WHITE RIVER BASIN Bover Whilte LRD AR 66 1120,0 1130,0 1652 300 5 Table Rock White LRD AR/MO 58 915.0 931.0 2702 760 526 Bull Shoals...Benbrook Trinity 391 Big Hill Arkansas 120 Birch Arkansas 151 Blue Mountain Arkansas 266 Broken Bow Red 331 Bull Shoals White 15 Canton Arkansas 234 Canyon...RELAT IONS fPqnC FRCcn :324-M24) AT DAM SITE OCTOBER~ FLOWS (PER~ TIpO C REVZR CC?45-1T7NS U.. MY ENGINEER DISTRICT. FORT WORTH TO RCCCMDR4Y tNSTR~qr

  19. The FEBS Journal in 2018 - putting a bit of color in your life, and your figures.

    PubMed

    Martin, Seamus J

    2018-01-01

    Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. He works on all aspects of cell death control and is especially interested in the links between cell death, cell stress and inflammation. He received the GlaxoSmithKline Award of The Biochemical Society (2006) and The RDS-Irish Times Boyle Medal (2015) for his work on the role of caspases in apoptosis and was elected to the Royal Irish Academy in 2006 and EMBO in 2009. He is the Editor-in-Chief of The FEBS Journal since 2014. © 2018 Federation of European Biochemical Societies.

  20. Life beneath the surface of the central Texan Balcones Escarpment: genus Anillinus Casey, 1918 (Coleoptera, Carabidae, Bembidiini): new species, a key to the Texas species, and notes about their way of life and evolution

    PubMed Central

    Sokolov, Igor M.; Reddell, James R.; Kavanaugh, David H.

    2014-01-01

    Abstract The Texas fauna of the genus Anillinus Casey, 1918 includes three previously described species (A. affabilis (Brues), 1902, A. depressus (Jeannel), 1963 and A. sinuatus (Jeannel), 1963) and four new species here described: A. acutipennis Sokolov & Reddell, sp. n. (type locality: Fort Hood area, Bell County, Texas); A. comalensis Sokolov & Kavanaugh, sp. n. (type locality: 7 miles W of New Braunfels, Comal County, Texas); A. forthoodensis Sokolov & Reddell, sp. n. (type locality: Fort Hood area, Bell County, Texas); A. wisemanensis Sokolov & Kavanaugh, sp. n. (type locality: Wiseman Sink, Hays County, Texas). A key for identification of adults of these species is provided. The fauna includes both soil- and cave-inhabiting species restricted to the Balcones Fault Zone and Lampasas Cut Plain and adjacent areas underlain by the Edwards-Trinity Aquifer. Based on morphological and distributional data, we hypothesize that four lineages of endogean Anillinus species extended their geographical ranges from a source area in the Ouachita-Ozark Mountains to the Balconian region in central Texas. There the cavernous Edwards-Trinity aquifer system provided an excellent refugium as the regional climate in the late Tertiary and early Quaternary became increasingly drier, rendering life at the surface nearly impossible for small, litter-inhabiting arthropods. Isolated within the Edwards-Trinity aquifer system, these anilline lineages subsequently differentiated, accounting for the currently known diversity. The paucity of specimens and difficulty in collecting them suggest that additional undiscovered species remain to be found in the region. PMID:25061356

  1. Life beneath the surface of the central Texan Balcones Escarpment: genus Anillinus Casey, 1918 (Coleoptera, Carabidae, Bembidiini): new species, a key to the Texas species, and notes about their way of life and evolution.

    PubMed

    Sokolov, Igor M; Reddell, James R; Kavanaugh, David H

    2014-01-01

    The Texas fauna of the genus Anillinus Casey, 1918 includes three previously described species (A. affabilis (Brues), 1902, A. depressus (Jeannel), 1963 and A. sinuatus (Jeannel), 1963) and four new species here described: A. acutipennis Sokolov & Reddell, sp. n. (type locality: Fort Hood area, Bell County, Texas); A. comalensis Sokolov & Kavanaugh, sp. n. (type locality: 7 miles W of New Braunfels, Comal County, Texas); A. forthoodensis Sokolov & Reddell, sp. n. (type locality: Fort Hood area, Bell County, Texas); A. wisemanensis Sokolov & Kavanaugh, sp. n. (type locality: Wiseman Sink, Hays County, Texas). A key for identification of adults of these species is provided. The fauna includes both soil- and cave-inhabiting species restricted to the Balcones Fault Zone and Lampasas Cut Plain and adjacent areas underlain by the Edwards-Trinity Aquifer. Based on morphological and distributional data, we hypothesize that four lineages of endogean Anillinus species extended their geographical ranges from a source area in the Ouachita-Ozark Mountains to the Balconian region in central Texas. There the cavernous Edwards-Trinity aquifer system provided an excellent refugium as the regional climate in the late Tertiary and early Quaternary became increasingly drier, rendering life at the surface nearly impossible for small, litter-inhabiting arthropods. Isolated within the Edwards-Trinity aquifer system, these anilline lineages subsequently differentiated, accounting for the currently known diversity. The paucity of specimens and difficulty in collecting them suggest that additional undiscovered species remain to be found in the region.

  2. An evaluation of soil sampling for 137Cs using various field-sampling volumes.

    PubMed

    Nyhan, J W; White, G C; Schofield, T G; Trujillo, G

    1983-05-01

    The sediments from a liquid effluent receiving area at the Los Alamos National Laboratory and soils from an intensive study area in the fallout pathway of Trinity were sampled for 137Cs using 25-, 500-, 2500- and 12,500-cm3 field sampling volumes. A highly replicated sampling program was used to determine mean concentrations and inventories of 137Cs at each site, as well as estimates of spatial, aliquoting, and counting variance components of the radionuclide data. The sampling methods were also analyzed as a function of soil size fractions collected in each field sampling volume and of the total cost of the program for a given variation in the radionuclide survey results. Coefficients of variation (CV) of 137Cs inventory estimates ranged from 0.063 to 0.14 for Mortandad Canyon sediments, whereas CV values for Trinity soils were observed from 0.38 to 0.57. Spatial variance components of 137Cs concentration data were usually found to be larger than either the aliquoting or counting variance estimates and were inversely related to field sampling volume at the Trinity intensive site. Subsequent optimization studies of the sampling schemes demonstrated that each aliquot should be counted once, and that only 2-4 aliquots out of as many as 30 collected need be assayed for 137Cs. The optimization studies showed that as sample costs increased to 45 man-hours of labor per sample, the variance of the mean 137Cs concentration decreased dramatically, but decreased very little with additional labor.

  3. De novo transcriptome assembly of the calanoid copepod Neocalanus flemingeri: A new resource for emergence from diapause.

    PubMed

    Roncalli, Vittoria; Cieslak, Matthew C; Sommer, Stephanie A; Hopcroft, Russell R; Lenz, Petra H

    2018-02-01

    Copepods, small planktonic crustaceans, are key links between primary producers and upper trophic levels, including many economically important fishes. In the subarctic North Pacific, the life cycle of copepods like Neocalanus flemingeri includes an ontogenetic migration to depth followed by a period of diapause (a type of dormancy) characterized by arrested development and low metabolic activity. The end of diapause is marked by the production of the first brood of eggs. Recent temperature anomalies in the North Pacific have raised concerns about potential negative effects on N. flemingeri. Since diapause is a developmental program, its progress can be tracked using through global gene expression. Thus, a reference transcriptome was developed as a first step towards physiological profiling of diapausing females using high-throughput Illumina sequencing. The de novo transcriptome, the first for this species was designed to investigate the diapause period. RNA-Seq reads were obtained for dormant to reproductive N. flemingeri females. A high quality de novo transcriptome was obtained by first assembling reads from each individual using Trinity software followed by clustering with CAP3 Assembly Program. This assembly consisted of 140,841transcripts (contigs). Bench-marking universal single-copy orthologs analysis identified 85% of core eukaryotic genes, with 79% predicted to be complete. Comparison with other calanoid transcriptomes confirmed its quality and degree of completeness. Trinity assembly of reads originating from multiple individuals led to fragmentation. Thus, the workflow applied here differed from the one recommended by Trinity, but was required to obtain a good assembly. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  4. HIV-Related Cognitive Impairment of Orphans in Myanmar With Vertically Transmitted HIV Taking Antiretroviral Therapy.

    PubMed

    Linn, Kyaw; Fay, Alexander; Meddles, Katherine; Isbell, Sara; Lin, Phyo Nay; Thair, Cho; Heaps, Jodi; Paul, Robert; Mar, Soe Soe

    2015-12-01

    We determined the effect of perinatally acquired HIV on neurocognition in Myanmar children treated with antiretroviral therapy by comparison to demographically matched seronegative children. Myanmar has one of the highest HIV-1 prevalence rates in Southeast Asia. Studies from other resource-poor countries have shown that HIV-infected children differ in socioeconomic, nutritional and caregiver status compared to normal controls. Some vertically infected orphans in Myanmar reside separately from HIV-uninfected children in separate orphanages, thus the demographic variables of interest are naturally controlled. This study provides a unique evaluation of the neurocognitive effects of HIV in children, with control over key demographic variables. We hypothesized that HIV-infected orphans would perform significantly worse on cognitive indices compared with HIV-negative orphans. A battery of cognitive tests sensitive to HIV-associated impairments in children was administered to 28 perinatally acquired HIV-positive children and 31 HIV-negative children from two orphanages in Myanmar; 21 children from each cohort underwent testing at baseline and again after 12 months. Baseline comparison of the two groups indicated that the HIV-infected children performed poorly across all tests, with significant group differences in executive function, visuospatial reasoning, fine motor dexterity, and visual motor integration. On subsequent testing, both cohorts of children showed improvements across multiple domains, with no significant effect of age at treatment initiation. Our results demonstrate a strong effect of HIV infection on specific neurocognitive deficits in vertically infected children. Understanding viral and host determinants and timing and choice of antiretroviral therapy on cognition will be critical to preventing cognitive impairment of children with HIV. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. A cluster randomized trial of provider-initiated (Opt-out) HIV counseling and testing of tuberculosis patients in South Africa

    PubMed Central

    Pope, Diana S.; DeLuca, Andrea N.; Kali, Paula; Hausler, Harry; Sheard, Carol; Hoosain, Ebrahim; Chaudhary, Mohammed A.; Celentano, David D.; Chaisson, Richard E.

    2008-01-01

    Objective To determine whether implementation of provider-initiated HIV counseling would increase the proportion of tuberculosis patients that received HIV counseling and testing. Design Cluster-randomized trial with clinic as unit of randomization Setting Twenty, medium-sized primary care TB clinics in the Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape Province, South Africa Subjects A total of 754 adults (≥ 18 years) newly registered as tuberculosis patients the twenty study clinics Intervention Implementation of provider-initiated HIV counseling and testing. Main outcome measures Percentage of TB patients HIV counseled and tested. Secondary Percentage of patients HIV test positive and percentage of those that received cotrimoxazole and who were referred for HIV care. Results A total of 754 adults newly registered as tuberculosis patients were enrolled. In clinics randomly assigned to implement provider-initiated HIV counseling and testing, 20.7% (73/352) patients were counseled versus 7.7% (31/402) in the control clinics (p = 0.011), and 20.2 % (n = 71) versus 6.5% (n = 26) underwent HIV testing (p = 0.009). Of those patients counseled, 97% in the intervention clinics accepted testing versus 79% in control clinics (p =0.12). The proportion of patients identified as HIV-infected in intervention clinics was 8.5% versus 2.5% in control clinics (p=0.044). Fewer than 40% of patients with a positive HIV test were prescribed cotrimoxazole or referred for HIV care in either study arm. Conclusions Provider-initiated HIV counseling significantly increased the proportion of adult TB patients that received HIV counseling and testing, but the magnitude of the effect was small. Additional interventions to optimize HIV testing for TB patients urgently need to be evaluated. PMID:18520677

  6. A cluster-randomized trial of provider-initiated (opt-out) HIV counseling and testing of tuberculosis patients in South Africa.

    PubMed

    Pope, Diana S; Deluca, Andrea N; Kali, Paula; Hausler, Harry; Sheard, Carol; Hoosain, Ebrahim; Chaudhary, Mohammad A; Celentano, David D; Chaisson, Richard E

    2008-06-01

    To determine whether implementation of provider-initiated human immunodeficiency virus (HIV) counseling would increase the proportion of tuberculosis (TB) patients who received HIV counseling and testing. Cluster-randomized trial with clinic as the unit of randomization. Twenty, medium-sized primary care TB clinics in the Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape Province, South Africa. A total of 754 adults (18 years and older) newly registered as TB patients in the 20 study clinics. Implementation of provider-initiated HIV counseling and testing. Percentage of TB patients HIV counseled and tested. SECONDARY: Percentage of patients with HIV test positive, and percentage of those who received cotrimoxazole and who were referred for HIV care. : A total of 754 adults newly registered as TB patients were enrolled. In clinics randomly assigned to implement provider-initiated HIV counseling and testing, 20.7% (73/352) patients were counseled versus 7.7% (31/402) in the control clinics (P = 0.011), and 20.2% (n = 71) versus 6.5% (n = 26) underwent HIV testing (P = 0.009). Of those patients counseled, 97% in the intervention clinics accepted testing versus 79% in control clinics (P = 0.12). The proportion of patients identified as HIV infected in intervention clinics was 8.5% versus 2.5% in control clinics (P = 0.044). Fewer than 40% of patients with a positive HIV test were prescribed cotrimoxazole or referred for HIV care in either study arm. Provider-initiated HIV counseling significantly increased the proportion of adult TB patients who received HIV counseling and testing, but the magnitude of the effect was small. Additional interventions to optimize HIV testing for TB patients urgently need to be evaluated.

  7. 78 FR 67175 - Proposed Collection; 60-Day Comment Request: Incident HIV/Hepatitis B Virus Infections in South...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... by a group of controls (blood donors whose infectious tests are all negative). Cases and controls... designs. Due to the high rates of HIV and HBV infection in South African blood donors, a better... direct relevance for HIV and HBV control in the U.S. and globally. Further, the ability to identify...

  8. The Influence of Attributional Style on Substance Abuse and Risky Sexual Behavior among College Students

    ERIC Educational Resources Information Center

    Burnett, Audrey J.; Sabato, Todd M.; Walter, Katherine Ott; Kerr, Dianne L.; Wagner, Laurie; Smith, Amy

    2013-01-01

    HIV, AIDS, STIs, and unwanted pregnancy continue to impact young adults in the U.S. at a disproportionate rate, particularly during the college years. Attributional style (i.e., locus of control) influences one's HIV risk. Internal locus of control indicates a lower risk of HIV infection, whereas an external locus of control signals an increased…

  9. The Influence of Attributional Style on Substance Use and Risky Sexual Behavior among College Students

    ERIC Educational Resources Information Center

    Burnett, Audrey J.; Sabato, Todd M.; Wagner, Laurie; Smith, Amy

    2014-01-01

    HIV, AIDS, STIs, and unwanted pregnancy continue to impact young adults in the U. S. at a disproportionate rate, particularly during the college years. Attributional style (i.e., locus of control) influences one's HIV risk. Internal locus of control indicates a lower risk of HIV infection, whereas external locus of control signals an…

  10. Cumulative Psychosocial Risk is a Salient Predictor of Depressive Symptoms among Vertically HIV-Infected and HIV-Affected Adolescents at the Kenyan Coast.

    PubMed

    Abubakar, Amina; Van de Vijver, Fons J R; Hassan, Amin S; Fischer, Ronald; Nyongesa, Moses K; Kabunda, Beatrice; Berkley, James A; Stein, Alan; Newton, Charles R

    Little is known of mental health outcomes among vertically HIV-infected or HIV-affected adolescents in Africa. The current study set out to describe depressive symptoms and their correlates among vertically HIV-infected and HIV-affected adolescents at the Kenyan Coast. 130 adolescents (vertically HIV-infected [n = 44], HIV-affected [n = 53], and unexposed [n = 33]) and their caregivers participated in this cross-sectional study. An adapted version of the Beck Depression Inventory-11 (BDI) was administered to examine depressive symptoms in both adolescents and caregivers, together with measures of sociodemographic, medical, and anthropometric characteristics. Our analysis indicated a main effect of HIV status on mean BDI scores in HIV-infected (18.4 [SD = 8.3) and HIV-affected (16.8 [SD = 7.3]) adolescents compared to the community controls (12.0 [SD = 7.9]), F (2, 127) = 6.704, P = .002, η 2  = .095. Post hoc analysis showed that BDI scores of HIV-infected adolescents were higher than those of community controls (P < .001). Similarly, HIV-affected adolescents had BDI scores that were higher than those of community controls (P = .007). However, there was no difference in BDI scores between HIV-infected and HIV-affected adolescents (P = .304). A path analytic model indicated that cumulative psychosocial risk (orphanhood, family poverty, and caregiver depressive symptoms) were positive predictors of BDI scores among adolescents, while nutritional status had a limited role. Both HIV-infected and HIV-affected adolescents are at a high risk of experiencing depressive symptoms, largely due to the multiple psychosocial risk factors in their environment. The provision of adequate psychosocial support and counseling needs to become an integral part of the care program for adolescents from families living with HIV/AIDS at the Kenyan coast and other similar settings. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Randomized controlled trial of a cognitive-behavioral intervention for HIV-positive persons: an investigation of treatment effects on psychosocial adjustment.

    PubMed

    Carrico, Adam W; Chesney, Margaret A; Johnson, Mallory O; Morin, Stephen F; Neilands, Torsten B; Remien, Robert H; Rotheram-Borus, Mary Jane; Lennie Wong, F

    2009-06-01

    Questions remain regarding the clinical utility of psychological interventions for HIV-positive persons because randomized controlled trials have utilized stringent inclusion criteria and focused extensively on gay men. The present randomized controlled trial examined the efficacy of a 15-session, individually delivered cognitive-behavioral intervention (n = 467) compared to a wait-list control (n = 469) in a diverse sample of HIV-positive persons who reported HIV transmission risk behavior. Five intervention sessions that dealt with executing effective coping responses were delivered between baseline and the 5 months post-randomization. Additional assessments were completed through 25 months post-randomization. Despite previously documented reductions in HIV transmission risk, no intervention-related changes in psychosocial adjustment were observed across the 25-month investigation period. In addition, there were no intervention effects on psychosocial adjustment among individuals who presented with mild to moderate depressive symptoms. More intensive mental health interventions may be necessary to improve psychosocial adjustment among HIV-positive individuals.

  12. Natural Immunity to HIV: a delicate balance between strength and control.

    PubMed

    Poudrier, Johanne; Thibodeau, Valérie; Roger, Michel

    2012-01-01

    Understanding how the mucosal immune system in the human female reproductive tract might prevent or facilitate HIV infection has important implications for the design of effective interventions. We and others have established cohorts of highly-exposed, HIV-seronegative individuals, such as HIV-uninfected commercial sex workers, who have remained HIV-negative after more than 5 years of active prostitution. Observations obtained in studies of such individuals, who represent a model of natural immunity to HIV, indicate that HIV resistance may be associated with the host's capacity to preserve systemic integrity by constraining immune activity and controlling inflammatory conditions at the mucosal point of entry. This likely necessitates the orchestration of balanced, first-line and adaptive immune responses.

  13. Risky Decision Making Assessed With the Gambling Task in Adults with HIV

    PubMed Central

    Hardy, David J.; Hinkin, Charles H.; Castellon, Steven A.; Levine, Andrew J.; Lam, Mona N.

    2010-01-01

    Decision making was assessed using a laboratory gambling task in 67 adults with the Human Immunodeficiency Virus (HIV+) and in 19 HIV-seronegative (HIV−) control participants. Neurocognitive test performance across several domains was also analyzed to examine potential cognitive mechanisms of gambling task performance. As predicted, the HIV+ group performed worse on the gambling task, indicating greater risky decision making. Specifically, the HIV+ group selected more cards from the “risky” or disadvantageous deck that included relatively large payoffs but infrequent large penalties. The control group also selected such risky cards but quickly learned to avoid them. Exploratory analyses also indicated that in the HIV+ group, but not in the control group, gambling task performance was correlated with Stroop Interference performance and long delay free recall on the California Verbal Learning Test, suggesting the role of inhibitory processes and verbal memory in the poorer gambling task performance in HIV. These findings indicate the usefulness of the gambling task as a laboratory tool to examine risky decision making and cognition in the HIV population. PMID:16719628

  14. Is screening for fetal anomalies reliable in HIV-infected pregnant women? A multicentre study.

    PubMed

    Brossard, Philippe; Boulvain, Michel; Coll, Oriol; Barlow, Patricia; Aebi-Popp, Karoline; Bischof, Paul; Martinez de Tejada, Begoña

    2008-10-01

    To assess the impact of HIV infection on the reliability of the first-trimester screening for Down syndrome, using free beta-human chorionic gonadotrophin, pregnancy-associated plasma protein-A and fetal nuchal translucency, and of the second-trimester screening for neural tube defects, using alpha-fetoprotein. Multicentre study comparing the multiples of the median of markers for Down syndrome and neural tube defect screening among 214 HIV-infected pregnant women and 856 HIV-negative controls undergoing a first-trimester Down syndrome screening test, and 209 HIV-positive women and 836 HIV-negative controls with a risk evaluation for neural tube defect. The influence of treatment, chronic hepatitis and HIV disease characteristics were also evaluated. Multiples of the median medians for pregnancy-associated plasma protein-A and beta-human chorionic gonadotrophin were lower in HIV-positive women than controls (0.88 vs. 1.05 and 0.84 vs. 1.09, respectively; P < 0.005), but these differences had no impact on risk estimation; no differences were observed for the other markers. No association was found between HIV disease characteristics, antiretroviral treatment use at the time of screening or chronic hepatitis and marker levels. Screening for Down syndrome during the first trimester and for neural tube defect during the second trimester is accurate for HIV-infected women and should be offered, similar to HIV-negative women.

  15. HIV-1 proteins dysregulate motivational processes and dopamine circuitry.

    PubMed

    Bertrand, Sarah J; Mactutus, Charles F; Harrod, Steven B; Moran, Landhing M; Booze, Rosemarie M

    2018-05-18

    Motivational alterations, such as apathy, in HIV-1+ individuals are associated with decreased performance on tasks involving frontal-subcortical circuitry. We used the HIV-1 transgenic (Tg) rat to assess effect of long-term HIV-1 protein exposure on motivated behavior using sucrose (1-30%, w/v) and cocaine (0.01-1.0 mg/kg/infusion) maintained responding with fixed-ratio (FR) and progressive-ratio (PR) schedules of reinforcement. For sucrose-reinforced responding, HIV-1 Tg rats displayed no change in EC 50 relative to controls, suggesting no change in sucrose reinforcement but had a downward shifted concentration-response curves, suggesting a decrease in response vigor. Cocaine-maintained responding was attenuated in HIV-1 Tg rats (FR1 0.33 mg/kg/infusion and PR 1.0 mg/kg/infusion). Dose-response tests (PR) revealed that HIV-1 Tg animals responded significantly less than F344 control rats and failed to earn significantly more infusions of cocaine as the unit dose increased. When choosing between cocaine and sucrose, control rats initially chose sucrose but with time shifted to a cocaine preference. In contrast, HIV-1 disrupted choice behaviors. DAT function was altered in the striatum of HIV-1 Tg rats; however, prior cocaine self-administration produced a unique effect on dopamine homeostasis in the HIV-1 Tg striatum. These findings of altered goal directed behaviors may determine neurobiological mechanisms of apathy in HIV-1+ patients.

  16. Increases in Recent HIV Testing Among Men Who Have Sex With Men Coincide With the Centers for Disease Control and Prevention's Expanded Testing Initiative

    PubMed Central

    Cooley, Laura A.; Wejnert, Cyprian; Rose, Charles E.; Paz-Bailey, Gabriela; Taussig, Jennifer; Gern, Robert; Hoyte, Tamika; Salazar, Laura; White, Jianglan; Todd, Jeff; Bautista, Greg; Flynn, Colin; Sifakis, Frangiscos; German, Danielle; Isenberg, Debbie; Driscoll, Maura; Hurwitz, Elizabeth; Doherty, Rose; Wittke, Chris; Prachand, Nikhil; Benbow, Nanette; Melville, Sharon; Pannala, Praveen; Yeager, Richard; Sayegh, Aaron; Dyer, Jim; Sheu, Shane; Novoa, Alicia; Thrun, Mark; Al-Tayyib, Alia; Wilmoth, Ralph; Higgins, Emily; Griffin, Vivian; Mokotoff, Eve; MacMaster, Karen; Wolverton, Marcia; Risser, Jan; Rehman, Hafeez; Padgett, Paige; Bingham, Trista; Sey, Ekow Kwa; LaLota, Marlene; Metsch, Lisa; Forrest, David; Beck, Dano; Cardenas, Gabriel; Nemeth, Chris; Anderson, Bridget J.; Watson, Carol-Ann; Smith, Lou; Robinson, William T.; Gruber, DeAnn; Barak, Narquis; Murrill, Chris; Neaigus, Alan; Jenness, Samuel; Hagan, Holly; Reilly, Kathleen H.; Wendel, Travis; Cross, Helene; Bolden, Barbara; D'Errico, Sally; Wogayehu, Afework; Godette, Henry; Brady, Kathleen A.; Kirkland, Althea; Sifferman, Andrea; Miguelino-Keasling, Vanessa; Velasco, Al; Tovar, Veronica; Raymond, H. Fisher; De León, Sandra Miranda; Rolón-Colón, Yadira; Marzan, Melissa; Courogen, Maria; Jaenicke, Tom; Thiede, Hanne; Burt, Richard; Jia, Yujiang; Opoku, Jenevieve; Sansone, Marie; West, Tiffany; Magnus, Manya; Kuo, Irene

    2015-01-01

    According to National HIV Behavioral Surveillance system data, human immunodeficiency virus (HIV) testing increased among gay, bisexual, and other men who have sex with men from 2008 to 2011 in cities funded by the Centers for Disease Control and Prevention's Expanded Testing Initiative, suggesting that focused HIV testing initiatives might have positive effects. PMID:25352589

  17. 77 FR 18853 - Trinity River National Wildlife Refuge, Liberty County, TX; Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... the refuge. curricula, working with program, upon the local schools to meet completion of the State... fishing pier, at Champion Lake Public fishing piers at butterfly garden, Use Area, and construct Brierwood...

  18. 75 FR 8745 - Notice of Intent To Prepare a Resource Management Plan Amendment and Associated Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... of the Lower Clear Creek and Grass Valley Creek Areas of Critical Environmental Concern, Redding, CA...) and Grass Valley Creek (in eastern Trinity County) as Areas of Critical Environmental Concern (ACEC...

  19. On the Front Lines: Presidents Build Institutional Image.

    ERIC Educational Resources Information Center

    Justiz, Manuel J.; And Others

    1986-01-01

    The principles used by college presidents in enhancing their institutions' images are outlined and illustrated in profiles of the presidents' roles at the University of South Carolina, Trinity University, Tuskegee University, and the Community College of Philadelphia. (MSE)

  20. 75 FR 26942 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... Service, 9th Floor, Room 9802B, 1201 New York Avenue, NW., Washington, DC 20525. Phone (202) 606-6696. Fax (202) 606-3462. TDD: (202) 606-3472. E-mail: [email protected] . Dated: May 10, 2010. Frank R. Trinity...

  1. Trinity sure-II

    NASA Astrophysics Data System (ADS)

    Swartz, Clifford E.

    1998-11-01

    What could be simpler? Exert a force on a mass, and it accelerates. F=ma! You can work that formula into any number of problems about objects on inclined planes, or Atwood's machine, or blocks sliding along a surface with coefficient of friction, μ.

  2. Geomorphology of the Trinity River floodplain in Dallas County, Texas

    NASA Astrophysics Data System (ADS)

    Haugen, B. D.; Roig-Silva, C.; Manning, A. R.; Harrelson, D. W.; Olsen, R. S.; Dunbar, J. P.; Pearson, M. L.

    2010-12-01

    Data from more than 1,800 geologic borings and over 500 cone penetrometer tests (CPTs) were used to characterize the geomorphology of the Trinity River floodplain in the Dallas Metropolitan Area. Historical maps, aerial photographs and other published information were used to prepare a preliminary geomorphic map. Boring logs and CPT data were then used to refine the preliminary map, produce a series of two-dimensional (2D) and three-dimensional (3D) cross sections, and interpret the recent geologic history of the area. Geomorphologic interpretations - most importantly the locations of paleo-channel deposits of sands and gravels - were used to identify reaches of the levees managed by the United States Army Corps of Engineers (USACE) and the City of Dallas that may be at significant risk for under-seepage. Boring logs and CPT data collected atop the levees were used to assess through-seepage risks. Local bedrock is comprised of cretaceous-age Eagle Ford Shale and Austin Chalk. Depth to bedrock in the study area averaged 14.6 m (47.8 ft). The uppermost surface of bedrock has been deeply incised by a meandering river. Vertical relief between the shallowest bedrock sections and deepest portion of the incised paleo-channel is more than 15 m (50 ft). In places the incised paleo-channel is more than 0.8 km (0.5 mi) wide. These data confirm the presence of an erosional unconformity between local bedrock and overlying quaternary floodplain deposits. The observed erosional unconformity is attributed to a higher-energy fluvial environment that occurred as a result of a drop in base level. Recent floodplain deposits consist of interlobate point bar, channel and overbank sediments that are generally distributed in a fining-upward sequence. Buried channel dimensions vary widely, but are more than 250 m (820 ft) in some areas - much larger than the current channel. A semi-continuous basal layer of quaternary sands and gravels approximately 2 to 5 m (7 to 16 ft) thick exists in much of the study area. These data indicate that the discharge rate of the Trinity River today is at its lowest since quaternary deposition began. Large terraces of varying geometry and elevation observed at the edge of the floodplain show that the Trinity River has been geographically constrained to its current floodplain since the late Cretaceous, and perhaps even earlier.

  3. Mandatory HIV testing in China: the perception of health-care providers.

    PubMed

    Li, Li; Wu, Zunyou; Wu, Sheng; Lee, Sung-Jae; Rotheram-Borus, Mary Jane; Detels, Roger; Jia, Manhong; Sun, Stephanie

    2007-07-01

    Health-care providers in China are facing an exponential increase in HIV testing and HIV-positive patients. A total of 1101 service providers were recruited to examine attitudes toward people living with HIV/AIDS (PLWHA) in China. Logistic regression models were used to assess factors associated with providers' attitudes toward mandatory HIV testing. Providers were most likely to endorse mandatory HIV testing for patients with high-risk behaviour and for all patients before surgery. Over 43% of providers endorsed mandatory testing for anyone admitted to hospital. Controlling for demographics, multivariate analyses indicated that providers with higher perceived risk of HIV infection at work, higher general prejudicial attitudes toward PLWHA, and previous contact with HIV patients were more likely to endorse mandatory HIV testing for anyone admitted to hospital. Results underscore the importance of implementing universal precautions in health-care settings and call attention to social and ethical issues associated with HIV/AIDS control and treatment in China.

  4. HIV Interventions to Reduce HIV/AIDS Stigma: A Systematic Review

    PubMed Central

    Banks, Bahby; Jonas, Dan; Miles, Margaret Shandor; Smith, Giselle Corbie

    2011-01-01

    We reviewed the literature to determine the effectiveness of HIV-related interventions in reducing HIV/AIDS stigma. Studies selected had randomized controlled trial (RCT), pretest–posttest with a non-randomized control group, or pretest–posttest one group study designs in which HIV-related interventions were being evaluated, and in which HIV/AIDS stigma was one of the outcomes being measured. A checklist was used to extract data from accepted studies, assess their internal validity, and overall quality. Data were extracted from 19 studies, and 14 of these studies demonstrated effectiveness in reducing HIV/ AIDS stigma. Only 2 of these 14 effective studies were considered good studies, based on quality, the extent to which the intervention focused on reducing HIV/AIDS stigma, and the statistics reported to demonstrate effectiveness. Future studies to reduce HIV/AIDS stigma could improve by designing interventions that pay greater attention to internal validity, use validated HIV/AIDS stigma instruments, and achieve both statistical and public health significance. PMID:21088989

  5. Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection.

    PubMed

    French, Martyn A; Abudulai, Laila N; Fernandez, Sonia

    2013-08-09

    The development of vaccines to treat and prevent human immunodeficiency virus (HIV) infection has been hampered by an incomplete understanding of "protective" immune responses against HIV. Natural control of HIV-1 infection is associated with T-cell responses against HIV-1 Gag proteins, particularly CD8⁺ T-cell responses restricted by "protective" HLA-B alleles, but other immune responses also contribute to immune control. These immune responses appear to include IgG antibodies to HIV-1 Gag proteins, interferon-a-dependant natural killer (NK) cell responses and plasmacytoid dendritic cell (pDC) responses. Here, it is proposed that isotype diversification of IgG antibodies against HIV-1 Gag proteins, to include IgG2, as well as IgG3 and IgG1 antibodies, will broaden the function of the antibody response and facilitate accessory cell responses against HIV-1 by NK cells and pDCs. We suggest that this should be investigated as a vaccination strategy for HIV-1 infection.

  6. HIV interventions to reduce HIV/AIDS stigma: a systematic review.

    PubMed

    Sengupta, Sohini; Banks, Bahby; Jonas, Dan; Miles, Margaret Shandor; Smith, Giselle Corbie

    2011-08-01

    We reviewed the literature to determine the effectiveness of HIV-related interventions in reducing HIV/AIDS stigma. Studies selected had randomized controlled trial (RCT), pretest-posttest with a non-randomized control group, or pretest-posttest one group study designs in which HIV-related interventions were being evaluated, and in which HIV/AIDS stigma was one of the outcomes being measured. A checklist was used to extract data from accepted studies, assess their internal validity, and overall quality. Data were extracted from 19 studies, and 14 of these studies demonstrated effectiveness in reducing HIV/AIDS stigma. Only 2 of these 14 effective studies were considered good studies, based on quality, the extent to which the intervention focused on reducing HIV/AIDS stigma, and the statistics reported to demonstrate effectiveness. Future studies to reduce HIV/AIDS stigma could improve by designing interventions that pay greater attention to internal validity, use validated HIV/AIDS stigma instruments, and achieve both statistical and public health significance.

  7. [Evaluation of the pro- and antioxidant status of women with HIV or coinfection].

    PubMed

    Kolesnikova, L I; Kolesnikov, S I; Darenskaya, M A; Grebenkina, L A; Timofeeva, E V; Leshchenko, O Ya; Vanteeva, O A; Rashidova, M A

    2016-01-01

    To reveal the specific features of changes in the parameters of lipid peroxidation - antioxidant defense and the status of the reproductive system in women of fertile age with monoinfection (HIV) or coinfection (HIV and hepatitis B and/or C). 81 reproductive-aged women were examined and divided into 3 groups: 1) 28 apparently healthy women (controls); 2) 26 patients with HIV monoinfection; and 3) 27 patients with HIV coinfection (HIV + hepatitis B and/or C) who had not previously received antiretroviral therapy. The HIV coinfection group showed the higher values of primary (conjugated dienes) and secondary (ketodienes and conjugated trienes) lipid peroxidation products in the presence of lower superoxide dismutase activity and obvious α-tocopherol deficiency than the control and HIV monoinfection groups. HIV coinfection in reproductive-aged women was accompanied by the high frequency of luteal phase deficiency. HIV coinfection is characterized by a more pronounced oxidative stress, antioxidant factor deficiency, and the high frequency of luteal phase deficiency in the patients.

  8. Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.

    PubMed

    Van Dalen, Yvonne W; Blokhuis, Charlotte; Cohen, Sophie; Ter Stege, Jacqueline A; Teunissen, Charlotte E; Kuhle, Jens; Kootstra, Neeltje A; Scherpbier, Henriette J; Kuijpers, Taco W; Reiss, Peter; Majoie, Charles B L M; Caan, Matthan W A; Pajkrt, Dasja

    2016-03-01

    Despite treatment with combination antiretroviral therapy (cART), cognitive impairment is still observed in perinatally HIV-infected children. We aimed to evaluate potential underlying cerebral injury by comparing neurometabolite levels between perinatally HIV-infected children and healthy controls. This cross-sectional study evaluated neurometabolites, as measured by Magnetic Resonance Spectroscopy (MRS), in perinatally HIV-infected children stable on cART (n = 26) and healthy controls (n = 36).Participants were included from a cohort of perinatally HIV-infected children and healthy controls, matched group-wise for age, gender, ethnicity, and socio-economic status. N-acetylaspartate (NAA), glutamate (Glu), myo-inositol (mI), and choline (Cho) levels were studied as ratios over creatine (Cre). Group differences and associations with HIV-related parameters, cognitive functioning, and neuronal damage markers (neurofilament and total Tau proteins) were determined using age-adjusted linear regression analyses.HIV-infected children had increased Cho:Cre in white matter (HIV-infected = 0.29 ± 0.03; controls = 0.27 ± 0.03; P value = 0.045). Lower nadir CD4+ T-cell Z-scores were associated with reduced neuronal integrity markers NAA:Cre and Glu:Cre. A Centers for Disease Control and Prevention (CDC) stage C diagnosis was associated with higher glial markers Cho:Cre and mI:Cre. Poorer cognitive performance was mainly associated with higher Cho:Cre in HIV-infected children, and with lower NAA:Cre and Glu:Cre in healthy controls. There were no associations between neurometabolites and neuronal damage markers in blood or CSF.Compared to controls, perinatally HIV-infected children had increased Cho:Cre in white matter, suggestive of ongoing glial proliferation. Levels of several neurometabolites were associated with cognitive performance, suggesting that MRS may be a useful method to assess cerebral changes potentially linked to cognitive outcomes.

  9. HERMITAGE – A Randomized Controlled Trial to Reduce Sexually Transmitted Infections and HIV-risk Behaviors among HIV-infected Russian Drinkers

    PubMed Central

    Samet, Jeffrey H.; Raj, Anita; Cheng, Debbie M.; Blokhina, Elena; Bridden, Carly; Chaisson, Christine E.; Walley, Alexander Y.; Palfai, Tibor P.; Quinn, Emily K.; Zvartau, Edwin; Lioznov, Dmitry; Krupitsky, Evgeny

    2014-01-01

    Aims This study assessed the effectiveness of HERMITAGE (HIV’s Evolution in Russia - Mitigating Infection Transmission and Alcoholism in a Growing Epidemic), an adapted secondary HIV prevention intervention, compared with an attention control condition in decreasing sexually transmitted infections (STIs) and sex and drug risk behaviors among Russian HIV-infected heavy drinkers. Design We conducted a single-blinded, two-armed, randomized controlled trial with 12-month follow-up. Setting The study was conducted in St. Petersburg, Russia. Participants were recruited from four HIV and addiction clinical sites. The intervention was conducted at Botkin Infectious Disease Hospital. Participants HIV-infected persons with past 6-month risky sex and heavy alcohol consumption (n=700) were randomized to the HERMITAGE intervention (n=350) or an attention control condition (n=350). Intervention A Healthy Relationships Intervention stressing disclosure of HIV serostatus and condom use, adapted for a Russian clinical setting with two individual sessions and three small group sessions. Measurements The primary outcome was incident STI by laboratory test at 12-month follow-up. Secondary outcomes included change in unprotected sex and several alcohol and injection drug use (IDU) variables. Findings Participants had the following baseline characteristics: 59% male, mean age 30, 60% past year IDU, 15.4% prevalent STI and mean CD4 cell count 413/μl. Assessment occurred among 75% and 71% of participants at 6 and 12-months, respectively. STIs occurred in 20 subjects (8%) in the intervention group and 28 subjects (12%) in the control group at 12-month follow-up; logistic regression analyses found no significant difference between groups (adjusted odds ratio 0.69; 95% CI: 0.36-1.30; P=0.25). Both groups decreased unsafe behaviors, although no significant differences between groups were found. Conclusions The HERMITAGE HIV risk reduction intervention does not appear to reduce sexually transmitted infections and HIV risk behaviors in Russian HIV-infected heavy drinkers compared with attention controls. PMID:25170994

  10. Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy.

    PubMed

    Montoya, Carlos J; Toro, Maria F; Aguirre, Carlos; Bustamante, Alberto; Hernandez, Mariluz; Arango, Liliana P; Echeverry, Marta; Arango, Ana E; Prada, Maria C; Alarcon, Herminia del P; Rojas, Mauricio

    2007-06-01

    Given that highly active antiretroviral therapy (HAART) has been demonstrated useful to restore immune competence in type-1 human immunodeficiency virus (HIV-1)-infected subjects, we evaluated the specific antibody response to influenza vaccine in a cohort of HIV-1-infected children on HAART so as to analyze the quality of this immune response in patients under antiretroviral therapy. Sixteen HIV-1-infected children and 10 HIV-1 seronegative controls were immunized with a commercially available trivalent inactivated influenza vaccine containing the strains A/H1N1, A/H3N2, and B. Serum hemagglutinin inhibition (HI) antibody titers were determined for the three viral strains at the time of vaccination and 1 month later. Immunization induced a significantly increased humoral response against the three influenza virus strains in controls, and only against A/H3N2 in HIV-1-infected children. The comparison of post-vaccination HI titers between HIV-1+ patients and HIV-1 negative controls showed significantly higher HI titers against the three strains in controls. In addition, post vaccination protective HI titers (defined as equal to or higher than 1:40) against the strains A/H3N2 and B were observed in a lower proportion of HIV-1+ children than in controls, while a similar proportion of individuals from each group achieved protective HI titers against the A/H1N1 strain. The CD4+ T cell count, CD4/CD8 T cells ratio, and serum viral load were not affected by influenza virus vaccination when pre- vs post-vaccination values were compared. These findings suggest that despite the fact that HAART is efficient in controlling HIV-1 replication and in increasing CD4+ T cell count in HIV-1-infected children, restoration of immune competence and response to cognate antigens remain incomplete, indicating that additional therapeutic strategies are required to achieve a full reconstitution of immune functions.

  11. HIV epidemic control-a model for optimal allocation of prevention and treatment resources.

    PubMed

    Alistar, Sabina S; Long, Elisa F; Brandeau, Margaret L; Beck, Eduard J

    2014-06-01

    With 33 million people living with human immunodeficiency virus (HIV) worldwide and 2.7 million new infections occurring annually, additional HIV prevention and treatment efforts are urgently needed. However, available resources for HIV control are limited and must be used efficiently to minimize the future spread of the epidemic. We develop a model to determine the appropriate resource allocation between expanded HIV prevention and treatment services. We create an epidemic model that incorporates multiple key populations with different transmission modes, as well as production functions that relate investment in prevention and treatment programs to changes in transmission and treatment rates. The goal is to allocate resources to minimize R 0, the reproductive rate of infection. We first develop a single-population model and determine the optimal resource allocation between HIV prevention and treatment. We extend the analysis to multiple independent populations, with resource allocation among interventions and populations. We then include the effects of HIV transmission between key populations. We apply our model to examine HIV epidemic control in two different settings, Uganda and Russia. As part of these applications, we develop a novel approach for estimating empirical HIV program production functions. Our study provides insights into the important question of resource allocation for a country's optimal response to its HIV epidemic and provides a practical approach for decision makers. Better decisions about allocating limited HIV resources can improve response to the epidemic and increase access to HIV prevention and treatment services for millions of people worldwide.

  12. CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection

    PubMed Central

    Freeman, Michael L.; Mudd, Joseph C.; Shive, Carey L.; Younes, Souheil-Antoine; Panigrahi, Soumya; Sieg, Scott F.; Lee, Sulggi A.; Hunt, Peter W.; Calabrese, Leonard H.; Gianella, Sara; Rodriguez, Benigno; Lederman, Michael M.

    2016-01-01

    Background. Persistent CD8 T-cell expansion, low CD4/CD8 T-cell ratios, and heightened inflammation persist in antiretroviral therapy (ART)-treated human immunodeficiency virus (HIV) infection and are associated with increased risk of morbid outcomes. We explored the role of cytomegalovirus (CMV) infection in CD8 lymphocytosis and inflammation in ART-treated HIV infection. Methods. Absolute CD4 and CD8 T-cell counts were abstracted from clinical records and compared among 32 HIV-infected CMV-seronegative subjects, 126 age, CD4 and gender-matched HIV-infected CMV-seropositive subjects, and among 21 HIV-uninfected controls (9 CMV-negative, 12 CMV-positive). Plasma inflammatory indices were measured in a subset by ELISA. Results. Median CD8 counts/µL were higher in HIV-positive/CMV-positive patients (795) than in HIV-positive/CMV-negative subjects (522, P = .006) or in healthy controls (451, P = .0007), whereas CD8 T-cell counts were similar to controls' levels in HIV-positive/CMV-negative subjects. Higher plasma levels of IP-10 (P = .0011), TNF-RII (P = .0002), and D-dimer (P = .0444) were also found in coinfected patients than in HIV-positive/CMV-negative subjects. Conclusions. CMV infection is associated with higher CD8 T-cell counts, resultant lower CD4/CD8 ratios, and increased systemic inflammation in ART-treated HIV infection. CMV infection may contribute to risk for morbid outcomes in treated HIV infection. PMID:26400999

  13. Mice chronically infected with chimeric HIV resist peripheral and brain superinfection: a model of protective immunity to HIV.

    PubMed

    Kelschenbach, Jennifer L; Saini, Manisha; Hadas, Eran; Gu, Chao-Jiang; Chao, Wei; Bentsman, Galina; Hong, Jessie P; Hanke, Tomas; Sharer, Leroy R; Potash, Mary Jane; Volsky, David J

    2012-06-01

    Infection by some viruses induces immunity to reinfection, providing a means to identify protective epitopes. To investigate resistance to reinfection in an animal model of HIV disease and its control, we employed infection of mice with chimeric HIV, EcoHIV. When immunocompetent mice were infected by intraperitoneal (IP) injection of EcoHIV, they resisted subsequent secondary infection by IP injection, consistent with a systemic antiviral immune response. To investigate the potential role of these responses in restricting neurotropic HIV infection, we established a protocol for efficient EcoHIV expression in the brain following intracranial (IC) inoculation of virus. When mice were inoculated by IP injection and secondarily by IC injection, they also controlled EcoHIV replication in the brain. To investigate their role in EcoHIV antiviral responses, CD8+ T lymphocytes were isolated from spleens of EcoHIV infected and uninfected mice and adoptively transferred to isogenic recipients. Recipients of EcoHIV primed CD8+ cells resisted subsequent EcoHIV infection compared to recipients of cells from uninfected donors. CD8+ spleen cells from EcoHIV-infected mice also mounted modest but significant interferon-γ responses to two HIV Gag peptide pools. These findings suggest EcoHIV-infected mice may serve as a useful system to investigate the induction of anti-HIV protective immunity for eventual translation to human beings.

  14. Maternal HIV Serostatus, Mother–Daughter Sexual Risk Communication and Adolescent HIV Risk Beliefs and Intentions

    PubMed Central

    Hutchinson, M. Katherine; Duan, Lei; Jemmott, Loretta S.

    2012-01-01

    Daughters of HIV-positive women are often exposed to the same factors that placed their mothers at risk. This cross-sectional study (N = 176 dyads) examined HIV status, parent-teen sexual risk communication (PTSRC), and daughters’ abstinence and condom use beliefs and intentions. Maternal HIV status was not associated with PTSRC. Path analyses show that maternal depression was associated with PTSRC behavioral and normative beliefs; relationship satisfaction was associated with PTSRC normative and control beliefs. Control beliefs were solely predictive of maternal PTSRC intention. PTSRC was associated with adolescent behavioral and normative beliefs. Abstinence beliefs were associated with abstinence intentions; condom beliefs were associated with condom use intentions. Relationship satisfaction was associated with adolescent control beliefs about both abstinence and condom use. There is a need for interventions that help HIV-positive mothers recognize their daughter’s HIV risk and provide them with relationship building and parent process skills to help reduce these risks. PMID:22677973

  15. Scientific approaches to AIDS prevention and control in China.

    PubMed

    Teng, T; Shao, Y

    2011-04-01

    The HIV epidemic in China started among intravenous drug users in the late 1980s. The second wave of the epidemic was caused by an outbreak in the paid plasma donors in central China in the mid-1990s. Sexually transmitted HIV cases have steadily increased and comprised more than half the reported HIV/AIDS infections since 2007. In the last 5 years, there has been a sharp increase of HIV infection in men who have sex with men. The HIV epidemic in China has expanded from high-risk groups to the general population and from rural regions to urban areas. This brief article discusses the history of HIV epidemics in China and the challenges facing the current AIDS control efforts in the country. It explains that only scientific approaches can sustain the national AIDS control programs and introduce the type of research needed to address those challenges. The selected research areas include molecular epidemiology, drug resistance surveillance, and the Chinese HIV vaccine research.

  16. Maternal HIV serostatus, mother-daughter sexual risk communication and adolescent HIV risk beliefs and intentions.

    PubMed

    Cederbaum, Julie A; Hutchinson, M Katherine; Duan, Lei; Jemmott, Loretta S

    2013-09-01

    Daughters of HIV-positive women are often exposed to the same factors that placed their mothers at risk. This cross-sectional study (N = 176 dyads) examined HIV status, parent-teen sexual risk communication (PTSRC), and daughters' abstinence and condom use beliefs and intentions. Maternal HIV status was not associated with PTSRC. Path analyses show that maternal depression was associated with PTSRC behavioral and normative beliefs; relationship satisfaction was associated with PTSRC normative and control beliefs. Control beliefs were solely predictive of maternal PTSRC intention. PTSRC was associated with adolescent behavioral and normative beliefs. Abstinence beliefs were associated with abstinence intentions; condom beliefs were associated with condom use intentions. Relationship satisfaction was associated with adolescent control beliefs about both abstinence and condom use. There is a need for interventions that help HIV-positive mothers recognize their daughter's HIV risk and provide them with relationship building and parent process skills to help reduce these risks.

  17. Gut Microbiota Linked to Sexual Preference and HIV Infection.

    PubMed

    Noguera-Julian, Marc; Rocafort, Muntsa; Guillén, Yolanda; Rivera, Javier; Casadellà, Maria; Nowak, Piotr; Hildebrand, Falk; Zeller, Georg; Parera, Mariona; Bellido, Rocío; Rodríguez, Cristina; Carrillo, Jorge; Mothe, Beatriz; Coll, Josep; Bravo, Isabel; Estany, Carla; Herrero, Cristina; Saz, Jorge; Sirera, Guillem; Torrela, Ariadna; Navarro, Jordi; Crespo, Manel; Brander, Christian; Negredo, Eugènia; Blanco, Julià; Guarner, Francisco; Calle, Maria Luz; Bork, Peer; Sönnerborg, Anders; Clotet, Bonaventura; Paredes, Roger

    2016-03-01

    The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. In two independent cohorts of HIV-1-infected subjects and HIV-1-negative controls in Barcelona (n = 156) and Stockholm (n = 84), men who have sex with men (MSM) predominantly belonged to the Prevotella-rich enterotype whereas most non-MSM subjects were enriched in Bacteroides, independently of HIV-1 status, and with only a limited contribution of diet effects. Moreover, MSM had a significantly richer and more diverse fecal microbiota than non-MSM individuals. After stratifying for sexual orientation, there was no solid evidence of an HIV-specific dysbiosis. However, HIV-1 infection remained consistently associated with reduced bacterial richness, the lowest bacterial richness being observed in subjects with a virological-immune discordant response to antiretroviral therapy. Our findings indicate that HIV gut microbiome studies must control for HIV risk factors and suggest interventions on gut bacterial richness as possible novel avenues to improve HIV-1-associated immune dysfunction.

  18. Infection control in home-based care for people living with HIV/AIDS/TB in South Africa: an exploratory study.

    PubMed

    Akintola, Olagoke; Hangulu, Lydia

    2014-01-01

    The majority of HIV and AIDS patients in sub-Saharan African countries receive health care services at home. Yet research on infection control in home-based care settings is virtually non-existent. This study explored infection control practices in home-based care in a South African province with a high HIV/TB prevalence. We conducted interviews with 10 managers of home-based care organizations and 10 focus group discussions with 80 volunteer caregivers working in high HIV/TB prevalent communities in South Africa. Findings show that volunteers had insufficient training on infection control. Materials necessary for the maintenance of hygiene and protective equipment were in short supply and the protective equipment supplied was of poor quality. Home-based care patients lived in crowded and poor conditions, and family members were negatively disposed to the use of protective devices. Together, these factors put volunteers and family caregivers at risk of infection with HIV and TB. Health policy should address the training of volunteer caregivers and the regular supply of good quality materials to ensure effective infection control. It is also important to educate families on infection control. Finally, there is a need to integrate HIV and TB control at the community level.

  19. 75 FR 6675 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ..., Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human Immunodeficiency Virus (HIV... evaluation of applications received in response to ``HIV Prevention Projects for Community Based..., Extramural Programs, National Center for HIV, Hepatitis and Sexually Transmitted Diseases Prevention, 1600...

  20. Short and Long Term Cardiovascular Risk, Metabolic Syndrome Prevalence and HIV in Tanzania: A Cross-Sectional Study

    PubMed Central

    Kingery, Justin R; Alfred, Yona; Smart, Luke R; Nash, Emily; Todd, Jim; Naguib, Mostafa R; Downs, Jennifer A; Kalluvya, Samuel; Kataraihya, Johannes B; Peck, Robert N

    2016-01-01

    Objective To compare short and long term cardiovascular disease (CVD) risk scores and prevalence of metabolic syndrome in HIV-infected adults receiving and not receiving antiretroviral therapy (ART) to HIV-negative controls. Methods A cross-sectional study including: 151 HIV-infected, ART-naive, 150 HIV-infected on ART and 153 HIV-negative adults. Traditional cardiovascular risk factors were determined by standard investigations. The primary outcome was ACC/AHA ASCVD Risk Estimator lifetime CVD risk score. Secondary outcomes were ASCVD 10-year risk, Framingham risk scores, statin indication and metabolic syndrome. Results Compared to HIV-negative controls, more HIV-infected adults on ART were classified as high lifetime CVD risk (34.7% vs 17.0%, p<0.001) although 10-year risk scores were similar, a trend which was similar across multiple CVD risk models. In addition, HIV-infected adults on ART had a higher prevalence of metabolic syndrome vs HIV-negative controls (21.3% vs 7.8%, p=0.008), with 2 common clusters of risk factors. More than one-quarter (28.7%) of HIV-infected Tanzanian adults on ART meet criteria for statin initiation. Conclusions HIV-infected ART-treated individuals have high lifetime cardiovascular risk, and this risk seems to develop rapidly in the first 3–4 years of ART as does the development of clusters of metabolic syndrome criteria. These data identify a new subgroup of low short-term/high lifetime risk HIV-infected individuals on ART who do not currently meet criteria for CVD risk factor modification but require further study. PMID:27105648

  1. Effectiveness of a video-based motivational skills-building HIV risk-reduction intervention for female military personnel.

    PubMed

    Essien, E James; Mgbere, Osaro; Monjok, Emmanuel; Ekong, Ernest; Holstad, Marcia M; Kalichman, Seth C

    2011-01-01

    Anecdotal evidence suggests that the HIV/AIDS prevalence rates in several African armed forces are high, with gender inequality rendering female military personnel more vulnerable to the disease. The objective of this study was to replicate a successful videotape-based HIV prevention intervention among Nigerian female military personnel in an effort to establish the cross-cultural stability, feasibility and cost-effectiveness of this approach in resource-limited countries. Enlisted women (N346) were recruited from two cantonments in Southwestern Nigeria and randomly assigned to either (a) a 5-session video-based, small group, cognitive-behavioral, HIV prevention intervention, or (b) a 5-session, video-based, contact-matched, HIV education control condition. Participants provided self-report of their HIV/AIDS-related knowledge and sexual behaviors at baseline, 3 and 6 months after completing the intervention. The results indicate that the motivational skills-building intervention did not improve participants' knowledge of HIV/AIDS any better than did the HIV education control condition at each assessment period, but it significantly increased condom use among women in this group by 53.6% at 3-month follow-up. HIV preventive behaviors among women in the motivational skills-building intervention group improved significantly, being 2 and 3 times more, compared to women in the HIV education control group at 3-month and 6-month follow-up assessments. The intervention also significantly improved behavioral intentions of participants as well as reduced alcohol use before sex by 25%, after 3 months; and number of sexual partners by 12% after 6 months. Women in the intervention group were five times more likely than women in HIV education control group to suggest that their new male partners use condom. These findings indicate that a videotape-based, HIV prevention intervention is a feasible and effective approach to HIV prevention among female military personnel from sub-Saharan Africa. Copyright © 2010 Elsevier Ltd. All rights reserved.

  2. Effectiveness of a Video-Based Motivational Skills-Building HIV Risk-Reduction Intervention for Female Military Personnel

    PubMed Central

    Essien, E. James; Mgbere, Osaro; Monjok, Emmanuel; Ekong, Ernest; Holstad, Marcia M.; Kalichman, Seth C.

    2010-01-01

    Anecdotal evidence suggests that the HIV/AIDS prevalence rates in several African armed forces are high, with gender inequality rendering female military personnel more vulnerable to the disease. The object of this study was to replicate a successful videotape-based HIV prevention intervention among Nigerian female military personnel in an effort to establish the cross-cultural stability, feasible and cost-effectiveness of this approach in resource-limited countries. Enlisted women (N=346) were recruited from two cantonments in Southwestern Nigeria and randomly assigned to either (a) a 5-session video-based, small group, cognitive-behavioral, HIV prevention intervention or (b) a 5-session, video-based, contact-matched, HIV education control condition. Participants provided self-report of their HIV/AIDS-related knowledge and sexual behaviors at baseline, 3 and 6 months after completing the intervention. The results indicate that the motivational skills-building intervention did not improve participants’ knowledge of HIV/AIDS any better than did the HIV education control condition at each assessment period, but it significantly (p<0.05) increased condom use among women in this group by 53.6% at 3-month follow-up. HIV preventive behaviors among women in the motivational skills-building intervention group improved significantly (p<0.01), being 2 and 3 times more, compared to women in the HIV education control group at 3-month and 6-month follow-up assessments. The intervention also significantly (p<0.001) improved behavioral intentions of participants as well as reduced alcohol use before sex by 25% (p<0.01), after 3 months; and number of sexual partners by 12% (p<0.05) after 6 months. Women in the intervention group were five times more likely than women in HIV education control group to suggest that their new male partners use condom. These findings indicate that a videotape-based, HIV prevention intervention is a feasible and effective approach to HIV prevention among female military personnel from sub-Saharan Africa. PMID:21106284

  3. The effect of integration of HIV care and treatment into antenatal care clinics on mother-to-child HIV transmission and maternal outcomes in Nyanza, Kenya: results from the SHAIP cluster randomized controlled trial

    PubMed Central

    Washington, Sierra; Owuor, Kevin; Turan, Janet M.; Steinfeld, Rachel L.; Onono, Maricianah; Shade, Starley B.; Bukusi, Elizabeth A.; Ackers, Marta L.; Cohen, Craig R.

    2015-01-01

    Background Many HIV-infected pregnant women identified during antenatal care do not enroll in long-term HIV care, resulting in deterioration of maternal health and continued risk of HIV transmission to infants. Methods We performed a cluster-randomized trial to evaluate the effect of integrating HIV care into ANC clinics in rural Kenya. Twelve facilities were randomized to provide either integrated services (ANC, PMTCT, and HIV care delivered in the ANC clinic; n=6 intervention facilities), or standard ANC services (including PMTCT and referral to a separate clinic for HIV care; n=6 control facilities). Results There were high patient attrition rates over the course of this study. Among study participants who enrolled in HIV care, there was twelve month follow up data for 256/611 (41.8%) women, and postpartum data for only 325/1172 (28%) women. By 9 months of age, 382/568 (67.3%) infants at intervention sites and 338/594 (57.0%) at control sites had tested for HIV (OR 1.45, 95% CI 0.71-2.82); 7.3% of infants tested HIV-positive at intervention sites compared to 8.0% of infants at control sites (OR 0.89, 95% CI 0.56-1.43). The composite clinical/immunologic progression into AIDS was similar in both arms (4.9% vs. 5.1 %, OR 0.83, 95% CI 0.41 - 1.68). Conclusions Despite the provision of integrated services, patient attrition was substantial in both arms, suggesting barriers beyond lack of service integration. Integration of HIV services into the ANC clinic was not associated with a reduced risk HIV transmission to infants and did not appear to affect short-term maternal health outcomes. PMID:25886930

  4. Increasing HIV testing engagement through provision of home HIV self-testing kits for patients who decline testing in the emergency department: a pilot randomisation study.

    PubMed

    Patel, Anuj V; Abrams, Samuel M; Gaydos, Charlotte A; Jett-Goheen, Mary; Latkin, Carl A; Rothman, Richard E; Hsieh, Yu-Hsiang

    2018-06-14

    Up to 60% of patients decline routine HIV testing offer in US emergency departments (EDs). The objective of this study is to determine whether the provision of HIV self-testing (HIVST) kit would increase engagement of HIV testing among these HIV test 'Decliners'. Patients who declined a test offered in an ED-based triage nurse-driven HIV screening programme were enrolled and randomised to either the HIVST or the control group. The patients in the HIVST group received HIVST kits to take home, were encouraged to report test results to an established internet-based STI/HIV testing recruitment website 'I Want the Kit' (IWTK) and received five referral cards for their peers to request HIVST kits from IWTK. The control group received pamphlets about publicly available HIV testing sites. HIV testing from both groups after enrolment was determined via telephone follow-up at 1 month. Testing rate ratio (RR) was determined using χ 2 tests. Fifty-two patients were randomised to the HIVST group and 48 to the control group. Among all 64 patients completing any follow-up, 14/29 (48%) patients in the HIVST group tested themselves at home with the provided kit. Four of these had never had an HIV test. Only 2/35 (6%) in the control group reported having an HIV test after enrolment (RR: 8.45 (95% CI: 2.09 to 34.17)). 57% (8/14) in the HIVST group reported test results to IWTK. Provision of HIVST kits supplements ED-based screening programme and significantly improved engagement of HIV testing among those test 'Decliners' in the ED. NCT03021005, results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  5. Disrupted trabecular bone micro-architecture in middle-aged male HIV-infected treated patients.

    PubMed

    Sellier, P; Ostertag, A; Collet, C; Trout, H; Champion, K; Fernandez, S; Lopes, A; Morgand, M; Clevenbergh, P; Evans, J; Souak, S; de Vernejoul, M-C; Bergmann, J-F

    2016-08-01

    HIV-infected individuals are at increased risk of incident fractures. Evaluation of trabecular bone micro-architecture is an important tool to assess bone strength, but its use has not yet been reported in middle-aged HIV-infected male individuals. The aim of the study was to compare bone micro-architecture between HIV-infected and HIV-uninfected men. In this cross-sectional study, 53 HIV-infected male individuals with a mean (± standard deviation) age of 49 ± 9 years who had been receiving antiretroviral therapy including tenofovir disoproxil fumarate (DF) for at least 60 months were compared with 50 HIV-uninfected male controls, matched for age and ethnic origin. We studied the volumetric bone density and micro-architecture of the radius and tibia using high-resolution peripheral quantitative computed tomography (HR-p QCT). Volumetric trabecular bone density was 17% lower in the tibia (P < 10(-4) ) and 16% lower in the radius (P < 10(-3) ) in HIV-infected patients compared with controls. By contrast, the cortical bone density was normal at both sites. The tibial trabecular micro-architecture differed markedly between patients and controls: bone volume/total volume (BV/TV) and trabecular number were each 13% lower (P < 10(-4) for both). Trabecular separation and inhomogeneity of the network were 18% and 24% higher in HIV-infected patients than in controls, respectively. The radial BV/TV and trabecular thickness were each 13% lower (P < 10(-3) and 10(-2) , respectively). Cortical thickness was not different between the two groups. The findings of lower volumetric trabecular bone density and disrupted trabecular micro-architectural parameters in middle-aged male HIV-infected treated patients help to explain bone frailty in these patients. © 2016 British HIV Association.

  6. Impact of teachers training on HIV/AIDS education program among secondary school students in Bangladesh: A cross-sectional survey.

    PubMed

    Sarma, Haribondhu; Islam, Mohammad Ashraful; Khan, Jahidur Rahman; Chowdhury, Kamal Ibne Amin; Gazi, Rukhsana

    2017-01-01

    In 2007, the Government of Bangladesh incorporated a chapter on HIV/AIDS into the national curriculum for an HIV-prevention program for school students. For the efficient dissemination of knowledge, an intervention was designed to train the teachers and equip them to educate on the topic of HIV/AIDS. The present study intended to understand the impact of this intervention by assessing the knowledge, attitudes and behaviours related to HIV/AIDS, among the targeted students. A cross-sectional survey was conducted with the students at randomly selected schools from two adjacent districts. Considering exposure to intervention, one district was assigned for intervention and the other as a control. In total, 1,381 students, aged 13-18 years (or above) were interviewed, 675 from the control areas and 706 from the intervention areas. Univariate and bivariate analyses were performed on the collected data. A significantly higher proportion (p<0.001) of students in the intervention areas attended HIV/AIDS classes, demonstrated better knowledge and fewer misconceptions regarding the transmission and prevention of HIV. The same was derived regarding their attitude towards people living with HIV, as a higher proportion (p<0.001) responded positively, compared to the control groups of the study. Additionally, multinomial logistic regression analysis showed that students in intervention area were more likely to have good knowledge on HIV transmission (OR 2.71, 95% CI 1.74-4.22) and prevention (OR 2.15, 95% CI 1.41-3.26) compared to the students in the control areas. The training programme needs to be scaled up, since it is likely to have an impact among students; we have witnessed that the interventions particularly helped increase HIV/AIDS knowledge among students and positively change the students' attitudes towards HIV/AIDS.

  7. Assessment of the HBV vaccine response in a group of HIV-infected children in Morocco.

    PubMed

    Haban, Houda; Benchekroun, Soumia; Sadeq, Mina; Benjouad, Abdelaziz; Amzazi, Said; Oumzil, Hicham; Elharti, Elmir

    2017-09-29

    Since its development in the early 1980s, Hepatitis B virus (HBV) vaccine has been proven to be highly protective. However, its immunogenicity may be ineffective among HIV-infected children. In Morocco, HBV vaccine was introduced in 1999, and since then all infants, including vertically HIV-infected infants, have been following the vaccination schedule, implemented by the Moroccan ministry of health. An assessment of the immunization of these children is important to optimize efforts aimed at tackling Hepatitis B coinfection, within the country. Forty-nine HIV-infected children (HIV group) and 112 HIV uninfected children (control group) were enrolled in this study. Samples were tested by Elisa (Monolisa Anti-HBs, Biorad) to quantify the anti-HBs antibodies. The % of lymphocyte subsets i.e. CD4+ T cells, CD8+ T cells, B cells, and NK, was determined by flow cytometry, using CellQuest Pro software (Becton-Dickinson), and for HIV group, HIV viral load was measured by real time PCR assay (Abbott). All variables were statistically compared in the two groups. The median age was 51 ± 35 months for the HIV group and 50 ± 36 months (p > 0.05) for the control group. Female represented 63% and 41% (p = 0.01), among the HIV group and the control group, respectively. Among HIV-infected children, 71.4% (35/49) were under HAART therapy at the enrollment in the study. Seroprotection titer i.e. anti-HBs ≥10mUI/ml among control group was 76% (85/112), and only 29% (14/49) among the perinatally HIV-infected children (p < 0.0001). Lower % of CD4 + T cells was observed in HIV-infected children with a poor anti-HBs response. In this studied group, we have shown that despite the vaccination of HIV-children with HBV vaccine, 71% did not show any seroprotective response. These findings support the need for monitoring HBV vaccine response among HIV-infected children in Morocco, in order to revaccinate non-immunized children.

  8. Risk of Breast Cancer with CXCR4-using HIV Defined by V3-Loop Sequencing

    PubMed Central

    Goedert, James J.; Swenson, Luke C.; Napolitano, Laura A.; Haddad, Mojgan; Anastos, Kathryn; Minkoff, Howard; Young, Mary; Levine, Alexandra; Adeyemi, Oluwatoyin; Seaberg, Eric C.; Aouizerat, Bradley; Rabkin, Charles S.; Harrigan, P. Richard; Hessol, Nancy A.

    2014-01-01

    Objective Evaluate the risk of female breast cancer associated with HIV-CXCR4 (X4) tropism as determined by various genotypic measures. Methods A breast cancer case-control study, with pairwise comparisons of tropism determination methods, was conducted. From the Women's Interagency HIV Study repository, one stored plasma specimen was selected from 25 HIV-infected cases near the breast cancer diagnosis date and 75 HIV-infected control women matched for age and calendar date. HIVgp120-V3 sequences were derived by Sanger population sequencing (PS) and 454-pyro deep sequencing (DS). Sequencing-based HIV-X4 tropism was defined using the geno2pheno algorithm, with both high-stringency DS [False-Positive-Rate (FPR 3.5) and 2% X4 cutoff], and lower stringency DS (FPR 5.75, 15% X4 cut-off). Concordance of tropism results by PS, DS, and previously performed phenotyping was assessed with kappa (κ) statistics. Case-control comparisons used exact P-values and conditional logistic regression. Results In 74 women (19 cases, 55 controls) with complete results, prevalence of HIV-X4 by PS was 5% in cases vs 29% in controls (P=0.06, odds ratio 0.14, confidence interval 0.003-1.03). Smaller case-control prevalence differences were found with high-stringency DS (21% vs 36%, P=0.32), lower-stringency DS (16% vs 35%, P=0.18), and phenotyping (11% vs 31%, P=0.10). HIV-X4-tropism concordance was best between PS and lower-stringency DS (93%, κ=0.83). Other pairwise concordances were 82%-92% (κ=0.56-0.81). Concordance was similar among cases and controls. Conclusions HIV-X4 defined by population sequencing (PS) had good agreement with lower stringency deep sequencing and was significantly associated with lower odds of breast cancer. PMID:25321183

  9. A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

    PubMed Central

    Mutlu, Ece A.; Keshavarzian, Ali; Losurdo, John; Swanson, Garth; Siewe, Basile; Forsyth, Christopher; French, Audrey; DeMarais, Patricia; Sun, Yan; Koenig, Lars; Cox, Stephen; Engen, Phillip; Chakradeo, Prachi; Abbasi, Rawan; Gorenz, Annika; Burns, Charles; Landay, Alan

    2014-01-01

    HIV progression is characterized by immune activation and microbial translocation. One factor that may be contributing to HIV progression could be a dysbiotic microbiome. We therefore hypothesized that the GI mucosal microbiome is altered in HIV patients and this alteration correlates with immune activation in HIV. 121 specimens were collected from 21 HIV positive and 22 control human subjects during colonoscopy. The composition of the lower gastrointestinal tract mucosal and luminal bacterial microbiome was characterized using 16S rDNA pyrosequencing and was correlated to clinical parameters as well as immune activation and circulating bacterial products in HIV patients on ART. The composition of the HIV microbiome was significantly different than that of controls; it was less diverse in the right colon and terminal ileum, and was characterized by loss of bacterial taxa that are typically considered commensals. In HIV samples, there was a gain of some pathogenic bacterial taxa. This is the first report characterizing the terminal ileal and colonic mucosal microbiome in HIV patients with next generation sequencing. Limitations include use of HIV-infected subjects on HAART therapy. PMID:24586144

  10. Genital Tract HIV RNA Levels and Their Associations with Human Papillomavirus Infection and Risk of Cervical Pre-Cancer

    PubMed Central

    GHARTEY, Jeny; KOVACS, Andrea; BURK, Robert D.; MASSAD, L. Stewart; MINKOFF, Howard; XIE, Xianhong; D’SOUZA, Gypsyamber; XUE, Xiaonan; WATTS, D. Heather; LEVINE, Alexandra M.; EINSTEIN, Mark H.; COLIE, Christine; ANASTOS, Kathryn; ELTOUM, Isam-Eldin; HEROLD, Betsy C.; PALEFSKY, Joel M.; STRICKLER, Howard D.

    2014-01-01

    Objective Plasma HIV RNA levels have been associated with risk of human papillomavirus (HPV) and cervical neoplasia in HIV-seropositive women. However, little is known regarding local genital tract HIV RNA levels and their relation with cervical HPV and neoplasia. Design/Methods In an HIV-seropositive women’s cohort with semi-annual follow-up, we conducted a nested case-control study of genital tract HIV RNA levels and their relation with incident high-grade squamous intraepithelial lesions sub-classified as severe (severe HSIL), as provided for under the Bethesda 2001 classification system. Specifically, 66 incident severe HSIL were matched to 130 controls by age, CD4+ count, HAART use, and other factors. We also studied HPV prevalence, incident detection, and persistence in a random sample of 250 subjects. Results Risk of severe HSIL was associated with genital tract HIV RNA levels (odds ratio comparing HIV RNA ≥ the median among women with detectable levels versus undetectable [ORVL] 2.96; 95% CI: 0.99–8.84; Ptrend=0.03). However, this association became non-significant (Ptrend=0.51) following adjustment for plasma HIV RNA levels. There was also no association between genital tract HIV RNA levels and the prevalence of any HPV or oncogenic HPV. However, the incident detection of any HPV (Ptrend=0.02) and persistence of oncogenic HPV (Ptrend=0.04) were associated with genital tract HIV RNA levels, after controlling plasma HIV RNA levels. Conclusion These prospective data suggest that genital tract HIV RNA levels are not a significant independent risk factor for cervical pre-cancer in HIV-seropositive women, but leave open the possibility that they may modestly influence HPV infection, an early stage of cervical tumoriogenesis. PMID:24694931

  11. Educational effectiveness of an HIV pretest video for adolescents: a randomized controlled trial.

    PubMed

    Calderon, Yvette; Cowan, Ethan; Nickerson, Jillian; Mathew, Sheba; Fettig, Jade; Rosenberg, Michael; Brusalis, Christopher; Chou, Katherine; Leider, Jason; Bauman, Laurie

    2011-05-01

    The goal of this study was to compare the effectiveness of a youth-friendly HIV video with in-person counseling in conveying HIV knowledge and obtaining consent for HIV testing among adolescent patients of an urban emergency department. A 2-armed, randomized controlled trial was conducted on a convenience sample of 200 stable, sexually active people aged 15 to 21 years in an urban emergency department. Participants in both the in-person counseling group and the video intervention group completed preintervention and postintervention HIV knowledge measures. HIV knowledge was the primary outcome measure, and consent for HIV testing was the secondary outcome. Characteristics associated with voluntary HIV testing were identified. Of 333 eligible people, 200 agreed to participate. There was no difference in preintervention HIV knowledge scores between groups. Mean postintervention knowledge scores differed significantly between the video (78.5% correct) and the counselor (66.3% correct) (P < 0.01) groups. Overall, 51% of the video group accepted HIV testing compared with 22% in the control group (P < .01). Watching the video (OR: 3.6 [95% CI: 1.8-7.2]), being female (OR: 2.1 [95% CI: 1.0-4.2]), engaging in oral sex (OR: 2.8 [95% CI: 1.4-5.9]), and being older than 18 years (OR: 3.8 [95% CI: 1.8-7.8]) were all positively associated with testing. A youth-friendly HIV educational video improved adolescents' HIV knowledge and increased their participation in HIV testing more than in-person counseling. video-based HIV counseling can perform as well or better than in-person counseling for adolescents in the ED.

  12. AMP!: A Cross-site Analysis of the Effects of a Theater-based Intervention on Adolescent Awareness, Attitudes, and Knowledge about HIV.

    PubMed

    Taggart, Tamara; Taboada, Arianna; Stein, Judith A; Milburn, Norweeta G; Gere, David; Lightfoot, Alexandra F

    2016-07-01

    AMP! (Arts-based, Multiple component, Peer-education) is an HIV intervention developed for high school adolescents. AMP! uses interactive theater-based scenarios developed by trained college undergraduates to deliver messages addressing HIV/STI prevention strategies, healthy relationships, and stigma reduction towards people living with HIV/AIDS. We used a pre-test/post-test, control group study design to simultaneously assess intervention effect on ninth grade students in an urban county in California (N = 159) and a suburban county in North Carolina (N = 317). In each location, the control group received standard health education curricula delivered by teachers; the intervention group received AMP! in addition to standard health education curricula. Structural equation modeling was used to determine intervention effects. The post-test sample was 46 % male, 90 % self-identified as heterosexual, 32 % reported receiving free or reduced lunch, and 49 % White. Structural models indicated that participation in AMP! predicted higher scores on HIV knowledge (p = 0.05), HIV awareness (p = 0.01), and HIV attitudes (p = 0.05) at the post-test. Latent means comparison analyses revealed post-test scores were significantly higher than pre-test scores on HIV knowledge (p = 0.001), HIV awareness (p = 0.001), and HIV attitudes (p = 0.001). Further analyses indicated that scores rose for both groups, but the post-test scores of intervention participants were significantly higher than controls (HIV knowledge (p = 0.01), HIV awareness (p = 0.01), and HIV attitudes (p = 0.05)). Thus, AMP!'s theater-based approach shows promise for addressing multiple adolescent risk factors and attitudes concerning HIV in school settings.

  13. Educational Effectiveness of an HIV Pretest Video for Adolescents: A Randomized Controlled Trial

    PubMed Central

    Cowan, Ethan; Nickerson, Jillian; Mathew, Sheba; Fettig, Jade; Rosenberg, Michael; Brusalis, Christopher; Chou, Katherine; Leider, Jason; Bauman, Laurie

    2011-01-01

    OBJECTIVE: The goal of this study was to compare the effectiveness of a youth-friendly HIV video with in-person counseling in conveying HIV knowledge and obtaining consent for HIV testing among adolescent patients of an urban emergency department. METHODS: A 2-armed, randomized controlled trial was conducted on a convenience sample of 200 stable, sexually active people aged 15 to 21 years in an urban emergency department. Participants in both the in-person counseling group and the video intervention group completed preintervention and postintervention HIV knowledge measures. HIV knowledge was the primary outcome measure, and consent for HIV testing was the secondary outcome. Characteristics associated with voluntary HIV testing were identified. RESULTS: Of 333 eligible people, 200 agreed to participate. There was no difference in preintervention HIV knowledge scores between groups. Mean postintervention knowledge scores differed significantly between the video (78.5% correct) and the counselor (66.3% correct) (P < 0.01) groups. Overall, 51% of the video group accepted HIV testing compared with 22% in the control group (P < .01). Watching the video (OR: 3.6 [95% CI: 1.8–7.2]), being female (OR: 2.1 [95% CI: 1.0–4.2]), engaging in oral sex (OR: 2.8 [95% CI: 1.4–5.9]), and being older than 18 years (OR: 3.8 [95% CI: 1.8–7.8]) were all positively associated with testing. CONCLUSIONS: A youth-friendly HIV educational video improved adolescents' HIV knowledge and increased their participation in HIV testing more than in-person counseling. video-based HIV counseling can perform as well or better than in-person counseling for adolescents in the ED. PMID:21482613

  14. Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity.

    PubMed

    Paul, Robert H; Phillips, Sarah; Hoare, Jacqueline; Laidlaw, David H; Cabeen, Ryan; Olbricht, Gayla R; Su, Yuqing; Stein, Dan J; Engelbrecht, Susan; Seedat, Soraya; Salminen, Lauren E; Baker, Laurie M; Heaps, Jodi; Joska, John

    2017-04-01

    Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient cohort studies identify significant neuropsychological impairment among HIV-C individuals independent of Tat variability. The present study clarified this discrepancy by examining neuroimaging markers of brain integrity among HIV-C individuals with and without the Tat substitution. Thirty-seven HIV-C individuals with the Tat C31S substitution, 109 HIV-C individuals without the Tat substitution (C31C), and 34 HIV- controls underwent 3T structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Volumes were determined for the caudate, putamen, thalamus, corpus callosum, total gray matter, and total white matter. DTI metrics included fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). Tracts of interest included the anterior thalamic radiation (ATR), cingulum bundle (CING), uncinate fasciculus (UNC), and corpus callosum (CC). HIV+ individuals exhibited smaller volumes in subcortical gray matter, total gray matter and total white matter compared to HIV- controls. HIV+ individuals also exhibited DTI abnormalities across multiple tracts compared to HIV- controls. By contrast, neither volumetric nor diffusion indices differed significantly between the Tat C31S and C31C groups. Tat C31S status is not a sufficient biomarker of HIV-related brain integrity in patient populations. Clinical attention directed at brain health is warranted for all HIV+ individuals, independent of Tat C31S or clade C status.

  15. Fertility and HIV following universal access to ART in Rwanda: a cross-sectional analysis of Demographic and Health Survey data.

    PubMed

    Remera, Eric; Boer, Kimberly; Umuhoza, Stella M; Hedt-Gauthier, Bethany L; Thomson, Dana R; Ndimubanzi, Patrick; Kayirangwa, Eugenie; Mutsinzi, Salomon; Bayingana, Alice; Mugwaneza, Placidie; Koama, Jean Baptiste T

    2017-03-14

    HIV infection is linked to decreased fertility and fertility desires in sub-Saharan Africa due to biological and social factors. We investigate the relationship between HIV infection and fertility or fertility desires in the context of universal access to antiretroviral therapy introduced in 2004 in Rwanda. We used data from 3532 and 4527 women aged 20-49 from the 2005 and 2010 Rwandan Demographic and Health Surveys (RDHS), respectively. The RDHSs included blood-tests for HIV, as well as detailed interviews about fertility, demographic and behavioral outcomes. In both years, multiple logistic regression was used to assess the association between HIV and fertility outcomes within three age categories (20-29, 30-39 and 40-49 years), controlling for confounders and compensating for the complex survey design. In 2010, we did not find a difference in the odds of pregnancy in the last 5 years between HIV-seropositive and HIV-seronegative women after controlling for potential biological and social confounders. Controlling for the same confounders, we found that HIV-seropositive women under age 40 were less likely to desire more children compared to HIV-seronegative women (20-29 years adjusted odds ratio (AOR) = 0.31, 95% CI: 0.17, 0.58; 30-39 years AOR = 0.24, 95% CI: 0.14, 0.43), but no difference was found among women aged 40 or older. No associations between HIV and fertility or fertility desire were found in 2005. These findings suggest no difference in births or current pregnancy among HIV-seropositive and HIV-seronegative women. That in 2010 HIV-seropositive women in their earlier childbearing years desired fewer children than HIV-seronegative women could suggest more women with HIV survived; and stigma, fear of transmitting HIV, or realism about living with HIV and prematurely dying from HIV may affect their desire to have children. These findings emphasize the importance of delivering appropriate information about pregnancy and childbearing to HIV-infected women, enabling women living with HIV to make informed decisions about their reproductive life.

  16. Marital sex among people living with HIV receiving antiretroviral treatment in northern Thailand.

    PubMed

    Le Coeur, Sophie; Bozon, Michel; Lelièvre, Eva; Sirijitraporn, Preecha; Pipustanawong, Narongdate; Cowatcharagul, Worawut; Pattanapornpun, Nopporn

    2014-01-01

    Before the advent of effective antiretroviral treatment (ART), the sexuality of people living with HIV was mostly discussed in terms of risk. To assess the extent to which ART allows people living with HIV to regain a regular sexual life, we surveyed all HIV-infected people treated in four hospitals in Northern Thailand and a control group from the general population matched by sex, age and residence. Data included socio-demographic and health characteristics, frequency of sexual intercourse in the last month and condom use. Our findings indicate that people living with HIV less often live in steady partnership (50% of the HIV-infected people versus 79% of the controls). After adjusting for factors known to influence sexuality, their probability of being sexually active was estimated to be about half that of the controls. When sexually active, men had a reduced sexual activity compared to controls (2.8 intercourse in the last month versus 4.0), while levels of reported sexual activity were similar among women (2.2 versus 2.8, respectively). Consistent condom use was high among people living with HIV (66% for women and 70% for men).

  17. Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density.

    PubMed

    Güerri-Fernández, Robert; Molina, Daniel; Villar-García, Judit; Prieto-Alhambra, Daniel; Mellibovsky, Leonardo; Nogués, Xavier; González-Mena, Alicia; Guelar, Ana; Trenchs-Rodríguez, Marta; Herrera-Fernández, Sabina; Horcajada, Juan Pablo; Díez-Pérez, Adolfo; Knobel, Hernando

    2016-07-01

    Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

  18. Evidence that intermittent structured treatment interruption, but not immunization with ALVAC-HIV vCP1452, promotes host control of HIV replication: the results of AIDS Clinical Trials Group 5068.

    PubMed

    Jacobson, Jeffrey M; Pat Bucy, R; Spritzler, John; Saag, Michael S; Eron, Joseph J; Coombs, Robert W; Wang, Rui; Fox, Lawrence; Johnson, Victoria A; Cu-Uvin, Susan; Cohn, Susan E; Mildvan, Donna; O'Neill, Dorothy; Janik, Jennifer; Purdue, Lynette; O'Connor, Deborah K; Vita, Christine Di; Frank, Ian

    2006-09-01

    The ability to control human immunodeficiency virus (HIV) replication in vivo in the absence of antiretroviral therapy (ART) is a measure of the efficiency of antiviral immunity. In a study of patients with chronic, ART-suppressed HIV infection, AIDS Clinical Trials Group 5068 investigated the effects of immunization with an exogenous HIV vaccine and pulse exposure to the subject's unique viral epitopes, by means of structured treatment interruptions (STIs), on the dynamics of viral rebound during a subsequent analytical treatment interruption (ATI). Ninety-seven subjects receiving stable ART with an HIV-1 RNA load <50 copies/mL and CD4(+) T lymphocyte count >400 cells/mm(3) were randomized to undergo continued ART, STIs, ALVAC-HIV vCP1452 immunization, or STIs and ALVAC-HIV vCP1452 immunization. Subjects in the 2 STI arms had a significantly longer median doubling time in the period of the initial rise of viral load, a significantly lower median peak viral load, a significantly lower median end-of-ATI viral load set point, and a greater proportion of subjects with an end-of-ATI viral load set point <1,000 copies/mL, compared with the subjects in the 2 arms without STIs. With an immunization schedule of 3 sets of 3 weekly injections, ALVAC-HIV vCP1452 did not affect viral load measures. In this randomized, controlled study of intermittent STI as a therapeutic autoimmunization strategy, evidence of enhanced immunologic control of HIV replication was demonstrated.

  19. Efficacy of SISTA South Africa on sexual behavior, HIV stigma and relationship control among isiXhosa women in the Western Cape Province, South Africa: Results of a Randomized Controlled Trial

    PubMed Central

    Wingood, Gina M.; Reddy, Priscilla; Lang, Delia L.; Saleh-Onoya, Dorina; Braxton, Nikia; Sifunda, Sibusiso; DiClemente, Ralph J

    2013-01-01

    Background The HIV epidemic has a devastating impact among South-African women. The current study evaluated the efficacy of SISTA South Africa, a culturally congruent HIV intervention for isiXhosa women in South Africa that was adapted from SISTA, an HIV intervention for African American women. Methods A randomized controlled trial recruited 342 isiXhosa women 18 – 35 years of age. Participants were randomized to the general health comparison or the SISTA South Africa intervention. Xhosa speaking peer health educators tailored the SISTA South Africa curriculum, while maintaining the core elements of the original SiSTA intervention. Participants completed assessments at baseline and 6 months follow-up. Results Relative to participants in the comparison, participants in the HIV intervention reduced the frequency of unprotected vaginal intercourse acts (adjusted mean difference = 1.06; p = .02), were more likely to report not desiring dry sex (AOR = .229; 95% CI = .10, .47; p = .0001) and, were more likely to perceive that their main sexual partner did not desire dry sex (AOR = .24; 95% CI = .11, .52; p = .0001). Additionally, women randomized to the intervention also reported an increase in HIV knowledge, greater relationship control and had more accepting attitudes towards HIV stigma. The HIV intervention did not reduce STI incidence. Conclusions This trial demonstrates that an HIV intervention which is adapted to enhance its gender and cultural relevance for rural isiXhosa women can reduce self-reported sexual risk behaviors and enhance mediators of HIV among this vulnerable population. PMID:23673889

  20. Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection.

    PubMed

    Sailasuta, Napapon; Ross, William; Ananworanich, Jintanat; Chalermchai, Thep; DeGruttola, Victor; Lerdlum, Sukalaya; Pothisri, Mantana; Busovaca, Edgar; Ratto-Kim, Silvia; Jagodzinski, Linda; Spudich, Serena; Michael, Nelson; Kim, Jerome H; Valcour, Victor

    2012-01-01

    Single voxel proton magnetic resonance spectroscopy (MRS) can be used to monitor changes in brain inflammation and neuronal integrity associated with HIV infection and its treatments. We used MRS to measure brain changes during the first weeks following HIV infection and in response to antiretroviral therapy (ART). Brain metabolite levels of N-acetyl aspartate (NAA), choline (tCHO), creatine (CR), myoinositol (MI), and glutamate and glutamine (GLX) were measured in acute HIV subjects (n = 31) and compared to chronic HIV+individuals (n = 26) and HIV negative control subjects (n = 10) from Bangkok, Thailand. Metabolites were measured in frontal gray matter (FGM), frontal white matter (FWM), occipital gray matter (OGM), and basal ganglia (BG). Repeat measures were obtained in 17 acute subjects 1, 3 and 6 months following initiation of ART. After adjustment for age we identified elevated BG tCHO/CR in acute HIV cases at baseline (median 14 days after HIV infection) compared to control (p = 0.0014), as well as chronic subjects (p = 0.0023). A similar tCHO/CR elevation was noted in OGM; no other metabolite abnormalities were seen between acute and control subjects. Mixed longitudinal models revealed resolution of BG tCHO/CR elevation after ART (p = 0.022) with tCHO/CR similar to control subjects at 6 months. We detected cellular inflammation in the absence of measurable neuronal injury within the first month of HIV infection, and normalization of this inflammation following acutely administered ART. Our findings suggest that early ART may be neuroprotective in HIV infection by mitigating processes leading to CNS injury.

  1. Computer-generated reminders and quality of pediatric HIV care in a resource-limited setting.

    PubMed

    Were, Martin C; Nyandiko, Winstone M; Huang, Kristin T L; Slaven, James E; Shen, Changyu; Tierney, William M; Vreeman, Rachel C

    2013-03-01

    To evaluate the impact of clinician-targeted computer-generated reminders on compliance with HIV care guidelines in a resource-limited setting. We conducted this randomized, controlled trial in an HIV referral clinic in Kenya caring for HIV-infected and HIV-exposed children (<14 years of age). For children randomly assigned to the intervention group, printed patient summaries containing computer-generated patient-specific reminders for overdue care recommendations were provided to the clinician at the time of the child's clinic visit. For children in the control group, clinicians received the summaries, but no computer-generated reminders. We compared differences between the intervention and control groups in completion of overdue tasks, including HIV testing, laboratory monitoring, initiating antiretroviral therapy, and making referrals. During the 5-month study period, 1611 patients (49% female, 70% HIV-infected) were eligible to receive at least 1 computer-generated reminder (ie, had an overdue clinical task). We observed a fourfold increase in the completion of overdue clinical tasks when reminders were availed to providers over the course of the study (68% intervention vs 18% control, P < .001). Orders also occurred earlier for the intervention group (77 days, SD 2.4 days) compared with the control group (104 days, SD 1.2 days) (P < .001). Response rates to reminders varied significantly by type of reminder and between clinicians. Clinician-targeted, computer-generated clinical reminders are associated with a significant increase in completion of overdue clinical tasks for HIV-infected and exposed children in a resource-limited setting.

  2. Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia.

    PubMed

    Darby, Robert; Van Howe, Robert

    2011-10-01

    To conduct a critical review of recent proposals that widespread circumcision of male infants be introduced in Australia as a means of combating heterosexually transmitted HIV infection. These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence-based medicine; the extent to which they take account of the evidence for circumcision having a protective effect against HIV and the practicality of circumcision as an HIV control strategy; the extent of its applicability to the specifics of Australia's HIV epidemic; the benefits, harms and risks of circumcision; and the associated human rights, bioethical and legal issues. Our conclusion is that such proposals ignore doubts about the robustness of the evidence from the African random-controlled trials as to the protective effect of circumcision and the practical value of circumcision as a means of HIV control; misrepresent the nature of Australia's HIV epidemic and exaggerate the relevance of the African random-controlled trials findings to it; underestimate the risks and harm of circumcision; and ignore questions of medical ethics and human rights. The notion of circumcision as a 'surgical vaccine' is criticised as polemical and unscientific. Circumcision of infants or other minors has no place among HIV control measures in the Australian and New Zealand context; proposals such as these should be rejected. © 2011 The Authors. ANZJPH © 2011 Public Health Association of Australia.

  3. Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals.

    PubMed

    Montoya, Carlos Julio; Velilla, Paula Andrea; Chougnet, Claire; Landay, Alan L; Rugeles, Maria Teresa

    2006-08-01

    The mechanisms involved in controlling the establishment of HIV-1 infection are not fully understood. In particular, the role of innate immunity in natural resistance exhibited by individuals who are continuously exposed to HIV-1 but remain seronegative (ESN) has not been thoroughly evaluated. We determined the frequency and function of peripheral blood innate immune cells (plasmacytoid and myeloid dendritic cells, monocytes, NK cells, CD3+/CD56+ cells and invariant NKT cells) in ESN, chronically HIV-1-infected and low-risk HIV-1 seronegative individuals. ESN demonstrated a similar frequency of innate immune cells in comparison to controls and a higher frequency of dendritic cells, NK and invariant NKT cells compared to HIV-1-infected subjects. Incubation of mononuclear cells with stimulatory CpG ODN induced CD86 and CD69 up-regulation to a similar degree on innate cells from the three study groups. CpG ODN-stimulated secretion of cytokines was also similar between ESN and controls, while secretion of IFN-alpha was significantly decreased in HIV-1+ individuals. Importantly, expression of IFN-gamma by PMA/Ionomycin-activated CD56(bright) NK cells and CD3+/CD56+ cells was significantly higher in ESN when compared with controls. The anti-viral effects of IFN-gamma are well established, and so our results suggest that IFN-gamma production by innate immune cells might be one of the multiple factors involved in controlling the establishment of sexually transmitted HIV-1 infection.

  4. Predictors of provider- initiated HIV testing and counseling refusal by outpatient department clients in Wolaita zone, Southern Ethiopia: a case control study.

    PubMed

    Facha, Wolde; Kassahun, Wondewosen; Workicho, Abdulhalik

    2016-08-12

    Despite different strategies designed to rapidly identify HIV infected individuals, majority of HIV-infected people are unaware of their sero-status in developing countries. The objective of this study was to assess predictors of provider-initiated HIV testing and counseling (PITC) refusal by outpatient department (OPD) clients in Wolaita zone, Southern Ethiopia. Facility based unmatched case control study was conducted on outpatient department clients in randomly selected seven health facilities in Wolaita zone, Southern Ethiopia in February 2012. A total of 291 participants (97 cases and 194 controls) were included in our study. Cases were patients who refused HIV test while controls were patients who tested for HIV after provider-initiated HIV testing and counseling (PITC) recommendation by outpatient department (OPD) clinicians. We used both quantitative and qualitative methods of data collection. Pretested interviewer administered questionnaires were used to collect quantitative data by trained nurses, and in-depth interview with 14 OPD clinicians was conducted by principal investigator to supplement quantitative findings. Bivariate and multivariate analyses were done to identify independent predictors of provider-initiated HIV testing and counseling refusal by OPD clients. Study participants who had stigmatizing attitude [AOR = 6.09, (95 % CI: 1.70, 21.76)], who had perceived risk for HIV infection [AOR = 5.23, (95 % CI: 2.22, 12.32)], who did not perceive the benefits of provider-initiated HIV testing and counseling [AOR = 4.64, (95 % CI: 1.79, 12.01)], who did not get minimum recommended pretest information from their providers [AOR = 2.98, (95 % CI: 1.06, 8.35)], who ever not heard of provider-initiated HIV testing and counseling service [AOR = 2.41, (95 % CI: 1.14, 5.09)], and who were from urban area [AOR = 2.40, (95 % CI = 1.26, 4.57)] were more likely to refuse provider-initiated HIV testing and counseling service than their counterparts. Knowledge on HIV/AIDS, attitude towards people living with HIV/AIDS and perceived risk for HIV infection by clients were the major barriers for provider-initiated HIV testing and counseling acceptance. Health professionals working at outpatient department should give due attention to overcome these barriers so as to enhance HIV testing acceptance by their clients.

  5. HIV reservoirs as obstacles and opportunities for an HIV cure.

    PubMed

    Chun, Tae-Wook; Moir, Susan; Fauci, Anthony S

    2015-06-01

    The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is discontinued, even if plasma viremia has been successfully suppressed for prolonged periods of time. Numerous approaches aimed at eradicating the virus, as well as maintaining its prolonged suppression in the absence of ART, have had little success. A better understanding of the pathophysiologic nature of HIV reservoirs and the impact of various interventions on their persistence is essential for the development of successful therapeutic strategies against HIV or the long-term control of infection. Here, we discuss the persistent HIV reservoir as a barrier to cure as well as the current therapeutic strategies aimed at eliminating or controlling the virus in the absence of ART.

  6. A Physical Theory of the Competition that Allows HIV to Escape from the Immune System

    NASA Astrophysics Data System (ADS)

    Deem, Michael

    2007-03-01

    Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies [1]. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The analytical model reproduces the three stages of HIV-1 infection. We propose a vaccine regimen that may be able to reduce competition between T cells, potentially eliminating the third stage of HIV-1. 1) G. Wang and M. W. Deem, Phys. Rev. Lett. 97 (2006) 188106.

  7. 77 FR 60138 - Trinity Adaptive Management Working Group; Public Teleconference/Web-Based Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... statements must be supplied to Elizabeth Hadley in one of the following formats: One hard copy with original... file formats are Adobe Acrobat PDF, MS Word, PowerPoint, or rich text file). Registered speakers who...

  8. 27 CFR 9.184 - Trinity Lakes.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... continue northwesterly along the contour line across Mule Creek and Snowslide Gulch in section 13, T35N/R9W; continue on the contour line, cross Little Mule Creek in section 18, T35N/R8W, and continue southeasterly...

  9. 27 CFR 9.184 - Trinity Lakes.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... continue northwesterly along the contour line across Mule Creek and Snowslide Gulch in section 13, T35N/R9W; continue on the contour line, cross Little Mule Creek in section 18, T35N/R8W, and continue southeasterly...

  10. 27 CFR 9.184 - Trinity Lakes.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... continue northwesterly along the contour line across Mule Creek and Snowslide Gulch in section 13, T35N/R9W; continue on the contour line, cross Little Mule Creek in section 18, T35N/R8W, and continue southeasterly...

  11. Timber resources of northern interior California, 1970.

    Treesearch

    Charles L. Bolsinger

    1976-01-01

    This report summarizes a timber resource inventory in Lassen, Modoc, Siskiyou, Shasta, and Trinity Counties, California. Included are detailed tables of forest area, timber volume, growth, mortality, and removals and a discussion of the current timber resource and timber industry situation.

  12. Clausewitz’s Trinity: Dead or Alive?

    DTIC Science & Technology

    2013-05-23

    Western and Japanese ideologies drastically affected the conduct of WWII in the Pacific Theater.104 The almost total dehumanization of the opponent served...racial indoctrination that influenced Allied forces’ perception of the nature of their enemy, exaggerating the effects of the dehumanization

  13. Trinity cable safety system.

    DOT National Transportation Integrated Search

    2007-01-31

    Cab1eSafety System (CASS).is being tested by the Oklahoma Department of Transportation (ODOT) along I-35 in McClain County. CASS will be compare with two other system approve by ODOT. Using C-shaped post tensioned cables, CASS is designed to...

  14. Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.

    PubMed

    Nunes-Cabaço, Helena; Matoso, Paula; Foxall, Russell B; Tendeiro, Rita; Pires, Ana R; Carvalho, Tânia; Pinheiro, Ana I; Soares, Rui S; Sousa, Ana E

    2015-02-01

    A unique HIV-host equilibrium exists in untreated HIV-2-infected individuals. This equilibrium is characterized by low to undetectable levels of viremia throughout the disease course, despite the establishment of disseminated HIV-2 reservoirs at levels comparable to those observed in untreated HIV-1 infection. Although the clinical spectrum is similar in the two infections, HIV-2 infection is associated with a much lower rate of CD4 T-cell decline and has a limited impact on the mortality of infected adults. Here we investigated HIV-2 infection of the human thymus, the primary organ for T-cell production. Human thymic tissue and suspensions of total or purified CD4 single-positive thymocytes were infected with HIV-2 or HIV-1 primary isolates using either CCR5 or CXCR4 coreceptors. We found that HIV-2 infected both thymic organ cultures and thymocyte suspensions, as attested to by the total HIV DNA and cell-associated viral mRNA levels. Nevertheless, thymocytes featured reduced levels of intracellular Gag viral protein, irrespective of HIV-2 coreceptor tropism and cell differentiation stage, in agreement with the low viral load in culture supernatants. Our data show that HIV-2 is able to infect the human thymus, but the HIV-2 replication cycle in thymocytes is impaired, providing a new model to identify therapeutic targets for viral replication control. HIV-1 infects the thymus, leading to a decrease in CD4 T-cell production that contributes to the characteristic CD4 T-cell loss. HIV-2 infection is associated with a very low rate of progression to AIDS and is therefore considered a unique naturally occurring model of attenuated HIV disease. HIV-2-infected individuals feature low to undetectable plasma viral loads, in spite of the numbers of circulating infected T cells being similar to those found in patients infected with HIV-1. We assessed, for the first time, the direct impact of HIV-2 infection on the human thymus. We show that HIV-2 is able to infect the thymus but that the HIV-2 replication cycle in thymocytes is impaired. We propose that this system will be important to devise immunotherapies that target viral production, aiding the design of future therapeutic strategies for HIV control. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  15. HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.

    PubMed

    Frange, Pierre; Faye, Albert; Avettand-Fenoël, Véronique; Bellaton, Erianna; Descamps, Diane; Angin, Mathieu; David, Annie; Caillat-Zucman, Sophie; Peytavin, Gilles; Dollfus, Catherine; Le Chenadec, Jerome; Warszawski, Josiane; Rouzioux, Christine; Sáez-Cirión, Asier

    2016-01-01

    Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption. The patient was identified in the ANRS EPF-CO10 paediatric cohort among 100 children infected with HIV perinatally who started ART before 6 months of age. HIV RNA viral load and CD4 cell counts were monitored from birth. Ultrasensitive HIV RNA, peripheral blood mononuclear cell (PBMC)-associated HIV DNA, HIV-specific T-cell responses (ie, production of cytokines and capacity to suppress HIV infection), reactivation of the CD4 cell reservoir (measured by p24 ELISA and HIV RNA in supernatants upon phytohaemagglutinin activation of purified CD4 cells), and plasma concentrations of antiretroviral drugs were assessed after 10 years of documented control off therapy. The infant was born in 1996 to a woman with uncontrolled HIV-1 viraemia and received zidovudine-based prophylaxis for 6 weeks. HIV RNA and DNA were not detected 3 days and 14 days after birth. HIV DNA was detected at 4 weeks of age. HIV RNA reached 2·17× 10(6) copies per mL at 3 months of age and ART was started. HIV RNA was undetectable 1 month later. ART was discontinued by the family at some point between 5·8 and 6·8 years of age. HIV RNA was undetectable at 6·8 years of age and ART was not resumed. HIV RNA has remained below 50 copies per mL and CD4 cell counts stable through to 18·6 years of age. After 11·5 years of control off treatment, HIV RNA was below 4 copies per mL and HIV DNA was 2·2 log10 copies per 10(6) PBMCs. The HLA genotype showed homozygosity at several loci (A*2301-, B*1503/4101, C*0210/0802, DRB1*1101-, and DQB1*0602-). HIV-specific CD8 T-cell responses and T-cell activation were weak. Findings from this case suggest that long-term HIV-1 remission is possible in perinatally infected children who receive treatment early, with characteristics similar to those reported in adult HIV post-treatment controllers. Further studies are needed to understand the mechanisms associated with HIV remission and whether early treatment of infected children might favour the conditions needed to achieve HIV control after treatment discontinuation. Agence de recherche ANRS (France Recherche Nord & Sud Sida-HIV Hépatites). Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients.

    PubMed

    Jaleco, A C; Covas, M J; Victorino, R M

    1994-11-01

    Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cell (PBMC) cultures from patients with HIV-1 or HIV-2 infection. PBMC from healthy controls (n = 28) and patients infected with HIV-1 (n = 26: asymptomatic (ASY)/persistent generalized lymphadenopathy (PGL), n = 16; and AIDS-related complex (ARC)/AIDS n = 10) or HIV-2 (n = 30: ASY/PGL, n = 16; ARC/AIDS, n = 14) were cultured in the absence or presence of mitogens (PHA, PWM) or superantigen (SEB). After 48 h, cell death (CD) was assessed by trypan blue exclusion and in some patients programmed cell death (PCD) was quantified in flow cytometry by measuring the percentage of hypodiploid nuclei corresponding to fragmented DNA, after treating the cells with a propidium iodide hypotonic solution. HIV-1 and HIV-2 ARC/AIDS patients and ASY/PGL HIV-1+ patients had significant increases in cell death percentages compared with controls, both in unstimulated and stimulated lymphocyte cultures. However, HIV-2+ ASY/PGL patients did not exhibit significant increases of cell death in unstimulated cultures. In addition, the comparison between HIV-1 and HIV-2 infected subjects in similar stages of disease, showed no significant differences in CD in the ARC/AIDS patients, although ASY/PGL HIV-2 infected subjects had lower levels of CD than the HIV-1+ ASY/PGL (3.4% +/- 0.6 s.e.m. versus 6.8% +/- 1.1 s.e.m., P < 0.01). PCD was significantly increased both in ASY/PGL (14.3% +/- 2.2 s.e.m., n = 8, P < 0.005) and in ARC/AIDS (25.3% +/- 4.5 s.e.m., n = 9, P < 0.001) HIV-1+ patients compared with healthy controls (5.8% +/- 1.7 s.e.m., n = 11). This contrasts with HIV-2 infected subjects where the ASY/PGL patients (10.0% +/- 2.8 s.e.m., n = 6) did not differ significantly from healthy controls, although ARC/AIDS patients (27.2% +/- 4.2 s.e.m., n = 9, P < 0.001) had significantly increased levels of PCD. In conclusion, this is the first report describing the occurrence of spontaneous and activation-induced lymphocyte death by apoptosis in HIV-1 infected subjects.(ABSTRACT TRUNCATED AT 400 WORDS)

  17. Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients.

    PubMed Central

    Jaleco, A C; Covas, M J; Victorino, R M

    1994-01-01

    Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cell (PBMC) cultures from patients with HIV-1 or HIV-2 infection. PBMC from healthy controls (n = 28) and patients infected with HIV-1 (n = 26: asymptomatic (ASY)/persistent generalized lymphadenopathy (PGL), n = 16; and AIDS-related complex (ARC)/AIDS n = 10) or HIV-2 (n = 30: ASY/PGL, n = 16; ARC/AIDS, n = 14) were cultured in the absence or presence of mitogens (PHA, PWM) or superantigen (SEB). After 48 h, cell death (CD) was assessed by trypan blue exclusion and in some patients programmed cell death (PCD) was quantified in flow cytometry by measuring the percentage of hypodiploid nuclei corresponding to fragmented DNA, after treating the cells with a propidium iodide hypotonic solution. HIV-1 and HIV-2 ARC/AIDS patients and ASY/PGL HIV-1+ patients had significant increases in cell death percentages compared with controls, both in unstimulated and stimulated lymphocyte cultures. However, HIV-2+ ASY/PGL patients did not exhibit significant increases of cell death in unstimulated cultures. In addition, the comparison between HIV-1 and HIV-2 infected subjects in similar stages of disease, showed no significant differences in CD in the ARC/AIDS patients, although ASY/PGL HIV-2 infected subjects had lower levels of CD than the HIV-1+ ASY/PGL (3.4% +/- 0.6 s.e.m. versus 6.8% +/- 1.1 s.e.m., P < 0.01). PCD was significantly increased both in ASY/PGL (14.3% +/- 2.2 s.e.m., n = 8, P < 0.005) and in ARC/AIDS (25.3% +/- 4.5 s.e.m., n = 9, P < 0.001) HIV-1+ patients compared with healthy controls (5.8% +/- 1.7 s.e.m., n = 11). This contrasts with HIV-2 infected subjects where the ASY/PGL patients (10.0% +/- 2.8 s.e.m., n = 6) did not differ significantly from healthy controls, although ARC/AIDS patients (27.2% +/- 4.2 s.e.m., n = 9, P < 0.001) had significantly increased levels of PCD. In conclusion, this is the first report describing the occurrence of spontaneous and activation-induced lymphocyte death by apoptosis in HIV-1 infected subjects.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:7955520

  18. Effectiveness of 7-Valent Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease in HIV-Infected and -Uninfected Children in South Africa: A Matched Case-Control Study

    PubMed Central

    Cohen, Cheryl; von Mollendorf, Claire; de Gouveia, Linda; Naidoo, Nireshni; Meiring, Susan; Quan, Vanessa; Nokeri, Vusi; Fortuin-de Smit, Melony; Malope-Kgokong, Babatyi; Moore, David; Reubenson, Gary; Moshe, Mamokgethi; Madhi, Shabir A.; Eley, Brian; Hallbauer, Ute; Kularatne, Ranmini; Conklin, Laura; O'Brien, Katherine L.; Zell, Elizabeth R.; Klugman, Keith; Whitney, Cynthia G.; von Gottberg, Anne; Moore, David; Verwey, Charl; Varughese, Sheeba; Archary, Moherndran; Naby, Fathima; Dawood, Khathija; Naidoo, Ramola; Elliott, Gene; Hallbauer, Ute; Eley, Brian; Nuttall, James; Cooke, Louise; Finlayson, Heather; Rabie, Helena; Whitelaw, Andrew; Perez, Dania; Jooste, Pieter; Naidoo, Dhamiran; Kularatne, Ranmini; Reubenson, Gary; Cohen, Cheryl; de Gouveia, Linda; du Plessis, Mignon; Govender, Nevashan; Meiring, Susan; Quan, Vanessa; von Mollendorf, Claire; Fortuin-de Smidt, Melony; Naidoo, Nireshni; Malope-Kgokong, Babatyi; Nokeri, Vusi; Ncha, Relebohile; Lindani, Sonwabo; von Gottberg, Anne; Spies, Barry; Sono, Lino; Maredi, Phasweni; Hamese, Ken; Moshe, Mamokgethi; Nchabeleng, Maphosane; Ngcobo, Ntombenhle; van den Heever, Johann; Madhi, Shabir; Conklin, Laura; Verani, Jennifer; Whitney, Cynthia; Zell, Elizabeth; Loo, Jennifer; Nelson, George; Klugman, Keith; O'Brien, Katherine

    2014-01-01

    Background. South Africa introduced 7-valent pneumococcal conjugate vaccine (PCV7) in April 2009 using a 2 + 1 schedule (6 and 14 weeks and 9 months). We estimated the effectiveness of ≥2 PCV7 doses against invasive pneumococcal disease (IPD) in human immunodeficiency virus (HIV)–infected and -uninfected children. Methods. IPD (pneumococcus identified from a normally sterile site) cases were identified through national laboratory-based surveillance. Specimens were serotyped by Quellung or polymerase chain reaction. Four controls, matched for age, HIV status, and hospital were sought for each case. Using conditional logistic regression, we calculated vaccine effectiveness (VE) as 1 minus the adjusted odds ratio for vaccination. Results. From March 2010 through November 2012, we enrolled 187 HIV-uninfected (48 [26%] vaccine serotype) and 109 HIV-infected (43 [39%] vaccine serotype) cases and 752 HIV-uninfected and 347 HIV-infected controls aged ≥16 weeks. Effectiveness of ≥2 PCV7 doses against vaccine-serotype IPD was 74% (95% confidence interval [CI], 25%–91%) among HIV-uninfected and −12% (95% CI, −449% to 77%) among HIV-infected children. Effectiveness of ≥3 doses against vaccine-serotype IPD was 90% (95% CI, 14%–99%) among HIV-uninfected and 57% (95% CI, −371% to 96%) among HIV-infected children. Among HIV-exposed but -uninfected children, effectiveness of ≥2 doses was 92% (95% CI, 47%–99%) against vaccine-serotype IPD. Effectiveness of ≥2 doses against all-serotype multidrug-resistant IPD was 96% (95% CI, 62%–100%) among HIV-uninfected children. Conclusions. A 2 + 1 PCV7 schedule was effective in preventing vaccine-serotype IPD in HIV-uninfected and HIV-exposed, uninfected children. This finding supports the World Health Organization recommendation for this schedule as an alternative to a 3-dose primary series among HIV-uninfected individuals. PMID:24917657

  19. Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS.

    PubMed

    Maelfait, Jonathan; Seiradake, Elena; Rehwinkel, Jan

    2014-07-01

    HIV-1 infects dendritic cells (DCs) without triggering an effective innate antiviral immune response. As a consequence, the induction of adaptive immune responses controlling virus spread is limited. In a recent issue of Immunity, Lahaye and colleagues show that intricate interactions of HIV capsid with the cellular cofactor cyclophilin A (CypA) control infection and innate immune activation in DCs. Manipulation of HIV-1 capsid to increase its affinity for CypA results in reduced virus infectivity and facilitates access of the cytosolic DNA sensor cGAS to reverse transcribed DNA. This in turn induces a strong host response. Here, we discuss these findings in the context of recent developments in innate immunity and consider the implications for disease control and vaccine design. © 2014 The Authors. Bioessays published by WILEY Periodicals, Inc.

  20. Experiences of HIV stigma: the role of visible symptoms, HIV centrality and community attachment for people living with HIV.

    PubMed

    Brener, Loren; Callander, Denton; Slavin, Sean; de Wit, John

    2013-01-01

    For many people living with HIV (PLHIV), disclosure or concealment of their HIV status may be under their personal control; however, for PLHIV with visible symptoms of their illness, disclosure may no longer be a choice. Previous research suggests that those with visible HIV symptoms have poorer mental and physical health than those without visible HIV symptoms. This study aimed to extend these findings and assess the role of perceived centrality of HIV in the lives of PLHIV as well as the role of attachment to an HIV-positive community in understanding the negative effects on health and well-being for PLHIV with visible HIV symptoms. Participants were 697 PLHIV who completed an online survey that assessed symptom visibility, HIV-status disclosure, perceived stigma, health and well-being, how central HIV was to identity and HIV community attachment. Results indicate that those with visible symptoms experienced more HIV-related stigma and had poorer outcomes on a range of psychological and mental health measures than those who were able to conceal their stigma. These effects remained after controlling for length of time since diagnosis, time on HIV treatment, perceived health satisfaction and age. PLHIV with visible symptoms also reported that HIV was more central to their identity and reported greater attachment to an HIV-positive community. Furthermore, findings suggest that while HIV centrality appears to increase the negative effects of having visible symptoms associated with HIV, greater community attachment seems to ameliorate these effects. This suggests the need for a nuanced understanding of the implications of visible HIV symptoms for PLHIV. The study also highlights the potential benefits of HIV-positive community attachment in buffering PLHIV from the negative effect of visible HIV symptoms on their health and well-being.

  1. A multivariate pattern analysis study of the HIV-related white matter anatomical structural connections alterations

    NASA Astrophysics Data System (ADS)

    Tang, Zhenchao; Liu, Zhenyu; Li, Ruili; Cui, Xinwei; Li, Hongjun; Dong, Enqing; Tian, Jie

    2017-03-01

    It's widely known that HIV infection would cause white matter integrity impairments. Nevertheless, it is still unclear that how the white matter anatomical structural connections are affected by HIV infection. In the current study, we employed a multivariate pattern analysis to explore the HIV-related white matter connections alterations. Forty antiretroviraltherapy- naïve HIV patients and thirty healthy controls were enrolled. Firstly, an Automatic Anatomical Label (AAL) atlas based white matter structural network, a 90 × 90 FA-weighted matrix, was constructed for each subject. Then, the white matter connections deprived from the structural network were entered into a lasso-logistic regression model to perform HIV-control group classification. Using leave one out cross validation, a classification accuracy (ACC) of 90% (P=0.002) and areas under the receiver operating characteristic curve (AUC) of 0.96 was obtained by the classification model. This result indicated that the white matter anatomical structural connections contributed greatly to HIV-control group classification, providing solid evidence that the white matter connections were affected by HIV infection. Specially, 11 white matter connections were selected in the classification model, mainly crossing the regions of frontal lobe, Cingulum, Hippocampus, and Thalamus, which were reported to be damaged in previous HIV studies. This might suggest that the white matter connections adjacent to the HIV-related impaired regions were prone to be damaged.

  2. The HOPE social media intervention for global HIV prevention in Peru: a cluster randomised controlled trial.

    PubMed

    Young, Sean D; Cumberland, William G; Nianogo, Roch; Menacho, Luis A; Galea, Jerome T; Coates, Thomas

    2015-01-01

    Social media technologies offer new approaches to HIV prevention and promotion of testing. We examined the efficacy of the Harnessing Online Peer Education (HOPE) social media intervention to increase HIV testing among men who have sex with men (MSM) in Peru. In this cluster randomised controlled trial, Peruvian MSM from Greater Lima (including Callao) who had sex with a man in the past 12 months, were 18 years of age or older, were HIV negative or serostatus unknown, and had a Facebook account or were willing to create one (N=556) were randomly assigned (1:1) by concealed allocation to join intervention or control groups on Facebook for 12 weeks. For the intervention, Peruvian MSM were trained and assigned to be HIV prevention mentors (peer-leaders) to participants in Facebook groups. The interventions period lasted 12 weeks. Participants in control groups received an enhanced standard of care, including standard offline HIV prevention available in Peru and participation in Facebook groups (without peer leaders) that provided study updates and HIV testing information. After accepting a request to join the groups, continued participation was voluntary. Participants also completed questionnaires on HIV risk behaviours and social media use at baseline and 12 week follow-up. The primary outcome was the number of participants who received a free HIV test at a local community clinic. The facebook groups were analysed as clusters to account for intracluster correlations. This trial is registered with ClinicalTrials.gov, number NCT01701206. Of 49 peer-leaders recruited, 34 completed training and were assigned at random to the intervention Facebook groups. Between March 19, 2012, and June 11, 2012, and Sept 26, 2012, and Dec 19, 2012, 556 participants were randomly assigned to intervention groups (N=278) or control groups (N=278); we analyse data for 252 and 246. 43 participants (17%) in the intervention group and 16 (7%) in the control groups got tested for HIV (adjusted odds ratio 2·61, 95% CI 1·55–4·38). No adverse events were reported. Development of peer-mentored social media communities seemed to be an efficacious method to increase HIV testing among high-risk populations in Peru. Results suggest that the HOPE social media intervention could improve HIV testing rates among MSM in Peru. National Institute of Mental Health.

  3. Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.

    PubMed

    Annamalay, Alicia A; Abbott, Salome; Sikazwe, Chisha; Khoo, Siew-Kim; Bizzintino, Joelene; Zhang, Guicheng; Laing, Ingrid; Chidlow, Glenys R; Smith, David W; Gern, James; Goldblatt, Jack; Lehmann, Deborah; Green, Robin J; Le Souëf, Peter N

    2016-08-01

    Human rhinovirus (RV) is the most common respiratory virus and has been associated with frequent and severe acute lower respiratory infections (ALRI). The prevalence of RV species among HIV-infected children in South Africa is unknown. To describe the prevalence of respiratory viruses, including RV species, associated with HIV status and other clinical symptoms in children less than two years of age with and without ALRI in Pretoria, South Africa. Nasopharyngeal aspirates were collected from 105 hospitalized ALRI cases and 53 non-ALRI controls less than two years of age. HIV status was determined. Common respiratory viruses were identified by PCR, and RV species and genotypes were identified by semi-nested PCR, sequencing and phylogenetic tree analyses. Respiratory viruses were more common among ALRI cases than controls (83.8% vs. 69.2%; p=0.041). RV was the most commonly identified virus in cases with pneumonia (45.6%) or bronchiolitis (52.1%), regardless of HIV status, as well as in controls (39.6%). RV-A was identified in 26.7% of cases and 15.1% of controls while RV-C was identified in 21.0% of cases and 18.9% of controls. HIV-infected children were more likely to be diagnosed with pneumonia than bronchiolitis (p<0.01). RSV was not identified in any HIV-infected cases (n=15) compared with 30.6% of HIV-uninfected cases (n=85, p=0.013), and was identified more frequently in bronchiolitis than in pneumonia cases (43.8% vs. 12.3%; p<0.01). RV-A and RV-C are endemic in South African children and HIV infection may be protective against RSV and bronchiolitis. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Host genetic determinants of HIV pathogenesis: an immunologic perspective.

    PubMed

    Hunt, Peter W; Carrington, Mary

    2008-05-01

    The purpose of this review is to highlight recent advances in our understanding of host genetic determinants of HIV pathogenesis and to provide a theoretical framework for interpreting these studies in the context of our evolving understanding of HIV immunopathogenesis. The first genome-wide association analysis of host determinants of HIV pathogenesis and other recent studies evaluating the interaction between killer cell immunoglobulin-like receptors and human leukocyte antigen alleles have implicated both adaptive and innate immune responses in the control of HIV replication. Furthermore, genetic variation associated with the expression of CCR5 and its ligand have been strongly associated with both decreased susceptibility to HIV infection and delayed clinical progression, independent of their effects on viral replication, suggesting a potential role for CCR5 inhibitors as immune-based therapies in HIV disease. Host factors associated with the control of HIV replication may help identify important targets for vaccine design, while those associated with delayed clinical progression provide targets for future immune-based therapies against HIV infection.

  5. Leveraging microfinance to impact HIV and financial behaviors among adolescents and their mothers in West Bengal: a cluster randomized trial.

    PubMed

    Spielberg, Freya; Crookston, Benjamin T; Chanani, Sheila; Kim, Jaewhan; Kline, Sean; Gray, Bobbi L

    2013-01-01

    Microfinance can be used to reach women and adolescent girls with HIV prevention education. We report findings from a cluster-randomized control trial among 55 villages in West Bengal to determine the impact of non-formal education on knowledge, attitudes and behaviors for HIV prevention and savings. Multilevel regression models were used to evaluate differences between groups for key outcomes while adjusting for cluster correlation and differences in baseline characteristics. Women and girls who received HIV education showed significant gains in HIV knowledge, awareness that condoms can prevent HIV, self-efficacy for HIV prevention, and confirmed use of clean needles, as compared to the control group. Condom use was rare and did not improve for women. While HIV testing was uncommon, knowledge of HIV-testing resources significantly increased among girls, and trended in the positive direction among women in intervention groups. Conversely, the savings education showed no impact on financial knowledge or behavior change.

  6. Mental Health of Children Living in Foster Families in Rural Rwanda: The Role of HIV and the Family Environment.

    PubMed

    Nduwimana, Estella; Mukunzi, Sylvere; Ng, Lauren C; Kirk, Catherine M; Bizimana, Justin I; Betancourt, Theresa S

    2017-06-01

    Fostering children is common in sub-Saharan Africa, but few studies examine these children's mental health needs. This study investigated the impact of living in a foster family on the mental health of HIV-positive, HIV-affected and HIV-unaffected children (n = 681 aged 10-17) in rural Rwanda. Regression analyses assessed the impact of living in a foster family on mental health, parenting, and daily hardships; multiple mediation analyses assessed whether family factors mediated the association between foster status and mental health. HIV-positive children were eight times more likely to live in foster families than HIV-unaffected children. Being HIV-affected was predictive of depression and irritability symptoms after controlling for family factors. Controlling for HIV-status, foster children had more symptoms of depression, anxiety, and irritability than non-fostered children. Positive parenting fully mediated the association between foster status and mental health. Mental health and parenting interventions for foster children and HIV-affected children may improve child outcomes.

  7. Using Facebook as a Platform to Direct Young Black Men Who Have Sex With Men to a Video-Based HIV Testing Intervention: A Feasibility Study

    PubMed Central

    Washington, Thomas Alex; Applewhite, Sheldon; Glenn, Wendell

    2017-01-01

    Objective A randomized control pilot study was conducted with Black men who have sex with men (BMSM; N = 42) aged 18–30 years to examine the feasibility of implementing a video intervention delivered using Facebook to motivate HIV testing. Methods At baseline, participants were unaware of their HIV status and had not tested for HIV in the past 6 months, residing in Los Angeles County. The intervention content included topics such as social influence, HIV knowledge, stigma, HIV positive knowledge, and benefits of knowing one’s HIV status. Findings Logistic regression revealed that those receiving the video intervention were 7 times more likely to have tested for HIV than those in the control group at 6-week follow-up (odds ratio [OR] = 7.00, 95% confidence interval [1.72, 28.33], p = .006). Conclusion Data suggest that the intervention was feasible for motivating HIV testing. PMID:29276800

  8. Total control: a critical analysis of mandatory HIV testing in U.S. prisons.

    PubMed

    Gagnon, Marilou; Jacob, Jean Daniel; Cormier, Luc

    2013-01-01

    The aim of this paper is to explore the relationship between mandatory HIV testing and the institutional management of inmates in U.S. prisons. Mandatory HIV testing has been largely overlooked by the nursing community even though it has important human rights and ethical implications. Drawing on the work of Goffman (1990) on the inner workings of total institutions, the present article critically examines the deployment of mandatory HIV testing in U.S. prisons. To set the stage, we define mandatory HIV testing and describe the methods of HIV testing currently used in U.S. prison settings. Then, we provide a brief overview of the concept of total institution and the mortification process. Finally, we expand on the relationship between mandatory HIV testing and much larger institutional objectives of total control, total structuring, total isolation, and separation of inmates from society (as summarized by Farrington, 1992). And lastly, we provide a brief discussion on the implications of mandatory HIV testing (as a method of HIV testing) from a nursing perspective.

  9. Effects of a behavioral intervention to reduce serodiscordant unsafe sex among HIV positive men who have sex with men: the Positive Connections randomized controlled trial study.

    PubMed

    Rosser, B R Simon; Hatfield, Laura A; Miner, Michael H; Ghiselli, Margherita E; Lee, Brian R; Welles, Seth L

    2010-04-01

    Few behavioral interventions have been conducted to reduce high-risk sexual behavior among HIV-positive Men who have Sex with Men (HIV+ MSM). Hence, we lack well-proven interventions for this population. Positive Connections is a randomized controlled trial (n = 675 HIV+ MSM) comparing the effects of two sexual health seminars--for HIV+ MSM and all MSM--with a contrast prevention video arm. Baseline, 6-, 12- and 18-month follow-up surveys assessed psychosexual variables and frequency of serodiscordant unprotected anal intercourse (SDUAI). At post-test, intentions to avoid transmission were significantly higher in the sexual health arms. However, SDUAI frequency decreased equally across arms. HIV+ MSM engaging in SDUAI at baseline were more likely to leave the study. Tailoring interventions to HIV+ MSM did not increase their effectiveness in this study. A sexual health approach appeared as effective as an untailored video-based HIV prevention intervention in reducing SDUAI among HIV+ MSM.

  10. Effects of Early, Abrupt Weaning on HIV-free Survival of Children in Zambia

    PubMed Central

    Kuhn, Louise; Aldrovandi, Grace M.; Sinkala, Moses; Kankasa, Chipepo; Semrau, Katherine; Mwiya, Mwiya; Kasonde, Prisca; Scott, Nancy; Vwalika, Cheswa; Walter, Jan; Bulterys, Marc; Tsai, Wei-Yann; Thea, Donald M.

    2008-01-01

    Background In low-resource settings, many programs recommend that women who are infected with the human immunodeficiency virus (HIV) stop breast-feeding early. We conducted a randomized trial to evaluate whether abrupt weaning at 4 months as compared with the standard practice has a net benefit for HIV-free survival of children. Methods We enrolled 958 HIV-infected women and their infants in Lusaka, Zambia. All the women planned to breast-feed exclusively to 4 months; 481 were randomly assigned to a counseling program that encouraged abrupt weaning at 4 months, and 477 to a program that encouraged continued breast-feeding for as long as the women chose. The primary outcome was either HIV infection or death of the child by 24 months. Results In the intervention group, 69.0% of the mothers stopped breast-feeding at 5 months or earlier; 68.8% of these women reported the completion of weaning in less than 2 days. In the control group, the median duration of breast-feeding was 16 months. In the overall cohort, there was no significant difference between the groups in the rate of HIV-free survival among the children; 68.4% and 64.0% survived to 24 months without HIV infection in the intervention and control groups, respectively (P = 0.13). Among infants who were still being breast-fed and were not infected with HIV at 4 months, there was no significant difference between the groups in HIV-free survival at 24 months (83.9% and 80.7% in the intervention and control groups, respectively; P = 0.27). Children who were infected with HIV by 4 months had a higher mortality by 24 months if they had been assigned to the intervention group than if they had been assigned to the control group (73.6% vs. 54.8%, P = 0.007). Conclusions Early, abrupt cessation of breast-feeding by HIV-infected women in a low-resource setting, such as Lusaka, Zambia, does not improve the rate of HIV-free survival among children born to HIV-infected mothers and is harmful to HIV-infected infants. (ClinicalTrials.gov number, NCT00310726.) PMID:18525036

  11. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers.

    PubMed

    Loke, P'ng; Favre, David; Hunt, Peter W; Leung, Jacqueline M; Kanwar, Bittoo; Martin, Jeffrey N; Deeks, Steven G; McCune, Joseph M

    2010-04-15

    HIV "controllers" are persons infected with human immunodeficiency virus, type I (HIV) who maintain long-term control of viremia without antiviral therapy and who usually do not develop the acquired immune deficiency syndrome (AIDS). In this study, we have correlated results from polychromatic flow cytometry and oligonucleotide expression arrays to characterize the mucosal immune responses of these subjects in relation to untreated HIV(+) persons with high viral loads and progressive disease ("noncontrollers"). Paired peripheral blood and rectosigmoid biopsies were analyzed from 9 controllers and 11 noncontrollers. Several cellular immune parameters were found to be concordant between the 2 compartments. Compared with noncontrollers, the mucosal tissues of controllers had similar levels of effector T cells and fewer regulatory T cells (Tregs). Using principal component analysis to correlate immunologic parameters with gene expression profiles, transcripts were identified that accurately distinguished between controllers and noncontrollers. Direct 2-way comparison also revealed genes that are significantly different in their expression between controllers and noncontrollers, all of which had reduced expression in controllers. In addition to providing an approach that integrates flow cytometry datasets with transcriptional profiling analysis, these results underscore the importance of the sustained inflammatory response that attends progressive HIV disease.

  12. A therapeutic HIV-1 vaccine enhances anti-HIV-1 immune responses in patients under highly active antiretroviral therapy.

    PubMed

    Tung, Frank Y; Tung, Jack K; Pallikkuth, Suresh; Pahwa, Savita; Fischl, Margaret A

    2016-04-27

    HIV-1 specific cellular immunity plays an important role in controlling viral replication. In this first-in-human therapeutic vaccination study, a replication-defective HIV-1 vaccine (HIVAX) was tested in HIV-1 infected participants undergoing highly active antiretroviral therapy (HAART) to enhance anti-HIV immunity (Clinicaltrials.gov, identifier NCT01428596). A010 was a randomized, placebo-controlled trial to evaluate the safety and the immunogenicity of a replication defective HIV-1 vaccine (HIVAX) given as a subcutaneous injection to HIV-1 infected participants who were receiving HAART with HIV-1 viral load <50 copies/ml and CD4 cell count >500 cells/mm(3). HIV-1 specific immune responses were monitored by INF-γ enzyme linked immunospot (Elispot) and intracellular cytokine staining (ICS) assay after vaccination. Following the randomized placebo-controlled vaccination phase, subjects who received HIVAX vaccine and who met eligibility underwent a 12-week analytical antiretroviral treatment interruption (ATI). Viral load was monitored throughout the study. HIVAX was well tolerated in trial participants. Transient grade 1 to 2 (mild to moderate) injection site reactions occurred in 8 of 10 vaccinated participants. HIVAX was immunogenic in all vaccinated participants. The functionality of T cells was significantly enhanced after vaccination. Median viral load (3.45 log10 copies/ml, range of 96-12,830 copies/ml) at the end of the 12-week treatment interruption in HIVAX vaccinated group was significantly lower than the pre-treatment levels. Three vaccinated participants extended ATI for up to 2 years with stable CD4 cells and low viral loads. HIVAX vaccine is generally safe, elicits strong anti-HIV-1 immune responses, and may play an important role in controlling viral load during treatment interruption in HIV-1 infected participants. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Impact of Human Immunodeficiency Virus on the Burden and Severity of Influenza Illness in Malawian Adults: A Prospective Cohort and Parallel Case-Control Study

    PubMed Central

    Ho, Antonia; Aston, Stephen J; Jary, Hannah; Mitchell, Tamara; Alaerts, Maaike; Menyere, Mavis; Mallewa, Jane; Nyirenda, Mulinda; Everett, Dean; Heyderman, Robert S; French, Neil

    2018-01-01

    Abstract Background The impact of human immunodeficiency virus (HIV) infection on influenza incidence and severity in adults in sub-Saharan Africa is unclear. Seasonal influenza vaccination is recommended for HIV-infected persons in developed settings but is rarely implemented in Africa. Methods We conducted a prospective cohort study to compare the incidence of laboratory-confirmed influenza illness between HIV-infected and HIV-uninfected adults in Blantyre, Malawi. In a parallel case-control study, we explored risk factors for severe influenza presentation of severe (hospitalized) lower respiratory tract infection, and mild influenza (influenza-like illness [ILI]). Results The cohort study enrolled 608 adults, of whom 360 (59%) were HIV infected. Between April 2013 and March 2015, 24 of 229 ILI episodes (10.5%) in HIV-infected and 5 of 119 (4.2%) in HIV-uninfected adults were positive for influenza by means of polymerase chain reaction (incidence rate, 46.0 vs 14.5 per 1000 person-years; incidence rate ratio, 2.75; 95% confidence interval, 1.02–7.44; P = .03; adjusted for age, sex, household crowding, and food security). In the case-control study, influenza was identified in 56 of 518 patients (10.8%) with hospitalized lower respiratory tract infection, and 88 or 642 (13.7%) with ILI. The HIV prevalence was 69.6% and 29.6%, respectively, among influenza-positive case patients and controls. HIV was a significant risk factor for severe influenza (odds ratio, 4.98; 95% confidence interval, 2.09–11.88; P < .001; population-attributable fraction, 57%; adjusted for season, sanitation facility, and food security). Conclusions HIV is an important risk factor for influenza-associated ILI and severe presentation in this high–HIV prevalence African setting. Targeted influenza vaccination of HIV-infected African adults should be reevaluated, and the optimal mechanism for vaccine introduction in overstretched health systems needs to be determined. PMID:29045699

  14. Neural response to working memory demand predicts neurocognitive deficits in HIV.

    PubMed

    Cohen, Ronald A; Siegel, S; Gullett, J M; Porges, E; Woods, A J; Huang, H; Zhu, Y; Tashima, K; Ding, M-Z

    2018-06-01

    Human immunodeficiency virus (HIV) continues to have adverse effects on cognition and the brain in many infected people, despite a reduced incidence of HIV-associated dementia with combined antiretroviral therapy (cART). Working memory is often affected, along with attention, executive control, and cognitive processing speed. Verbal working memory (VWM) requires the interaction of each of the cognitive component processes along with a phonological loop for verbal repetition and rehearsal. HIV-related functional brain response abnormalities during VWM are evident in functional MRI (fMRI), though the neural substrate underlying these neurocognitive deficits is not well understood. The current study addressed this by comparing 24 HIV+ to 27 demographically matched HIV-seronegative (HIV-) adults with respect to fMRI activation on a VWM paradigm (n-back) relative to performance on two standardized tests of executive control, attention and processing speed (Stroop and Trail Making A-B). As expected, the HIV+ group had deficits on these neurocognitive tests compared to HIV- controls, and also differed in neural response on fMRI relative to neuropsychological performance. Reduced activation in VWM task-related brain regions on the 2-back was associated with Stroop interference deficits in HIV+ but not with either Trail Making A or B performance. Activation of the posterior cingulate cortex (PCC) of the default mode network during rest was associated with Hopkins Verbal Learning Test-2 (HVLT-2) learning in HIV+. These effects were not observed in the HIV- controls. Reduced dynamic range of neural response was also evident in HIV+ adults when activation on the 2-back condition was compared to the extent of activation of the default mode network during periods of rest. Neural dynamic range was associated with both Stroop and HVLT-2 performance. These findings provide evidence that HIV-associated alterations in neural activation induced by VWM demands and during rest differentially predict executive-attention and verbal learning deficits. That the Stroop, but not Trail Making was associated with VWM activation suggests that attentional regulation difficulties in suppressing interference and/or conflict regulation are a component of working memory deficits in HIV+ adults. Alterations in neural dynamic range may be a useful index of the impact of HIV on functional brain response and as a fMRI metric in predicting cognitive outcomes.

  15. Risk of cancer among HIV-infected individuals compared to the background population: impact of smoking and HIV.

    PubMed

    Helleberg, Marie; Gerstoft, Jan; Afzal, Shoaib; Kronborg, Gitte; Larsen, Carsten S; Pedersen, Court; Bojesen, Stig E; Nordestgaard, Børge G; Obel, Niels

    2014-06-19

    The relative impact of immune deficiency and lifestyle-related factors on risk of cancer in the HIV-infected population is controversial. We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency. In a Danish, nationwide, population-based cohort study (1995-2011), incidences of cancer were compared between an HIV-infected cohort and a population-based matched cohort in analyses stratified on cancer category, smoking status and for HIV patients: low CD4 cell count. We included 3503 HIV patients [baseline CD4+ 450 cells/μl (inter-quartile range 310-630)] and 12,979 population controls. Smoking-related and virological cancers accounted for 23 and 43% of cancers in the HIV-infected population. The risk of these cancers were higher among HIV patients compared to controls [incidence rate ratio (IRR) 2.8, 95% confidence interval (CI) 1.6-4.9; and IRR 11.5, 95% CI 6.5-20.5], whereas the risk of other cancers did not differ (IRR 1.0, 95% CI 0.7-1.3). Non-smoking HIV patients did not have increased risk of non-virological cancers compared to non-smoking controls (IRR 1.2, 95% CI 0.7-2.1). The PAFs of cancer associated with smoking and with being HIV-infected were 27 and 49%, respectively. For cancers not strongly related to smoking or viral infections, the PAFs associated with being HIV-infected and with immune deficiency were 0%. The risk of cancer is increased in HIV patients compared to the background population. In absence of smoking, the increase in risk is confined to cancers related to viral infections, whereas the risk of other cancers is not elevated and does not seem to be associated with immune deficiency.

  16. Prevalence of Helicobacter pylori prevalence and upper gastrointestinal endoscopy in HIV/AIDS patients with gastrointestinal symptoms in the University Teaching Hospitals in Cameroon.

    PubMed

    Andoulo, F A; Kowo, M; Ngatcha, G; Ndam, A N; Awouoyiegnigni, B; Sida, M B; Tzeuton, C; Ndjitoyap Ndam, E C

    2016-08-01

    To determine the prevalence of Helicobacter pylori (H. pylori) infection and of various upper gastrointestinal (GI) lesions in HIV + patients with GI symptoms and the relation of H. pylori infection to CD4 cell counts. In all, 56 HIV + patients and 56 age- and sex-matched HIV - controls, all with upper GI symptoms, were evaluated by an upper endoscopy examination and gastric biopsy. H. pylori status was assessed with a urease test and histology. HIV was diagnosed with the rapid test and enzyme-linked immunosorbent assay (ELISA). The prevalence of H. pylori was 50% (28/56 [95%CI 36.3-63.7]) in HIV + subjects and 55% (31/56 [95%CI 41.5-68.7]) in HIV - controls (p = 0.57). H. pylori infection rates did not differ significantly in HIV + patients between those with a CD4 count ≥200/mm 3 (52%) and those with a CD4 count <200/mm 3 (42%) (p = 0.62). The prevalence on endoscopy of specific lesions in HIV + patients and controls were compared: esophageal candidiasis (61%, 34/56 vs. 7%; p<0.0001), esophageal ulcers (18%, 10/56 vs 2%; p = 0.01), corpus gastritis (41%; 23/56 vs 5%; p<0.0001), and duodenitis (20%, 11/56, vs 0%; p = 0.001). The prevalence rate of H. pylori did not differ significantly between HIV + and HIV - subjects. Prevalence of H. pylori was also lower, although not significantly, among HIV + patients with CD4 T-cell counts below 200/mm 3 . On endoscopy, esophageal candidiasis was the most common finding in HIV + patients, discovered by dysphagia.

  17. Genital mycoplasma & Chlamydia trachomatis infections in treatment naïve HIV-1 infected adults

    PubMed Central

    Ghosh, Arnab; Dhawan, Benu; Chaudhry, Rama; Vajpayee, Madhu; Sreenivas, Vishnubhatla

    2011-01-01

    Background & objectives: Sexually transmitted infections (STIs) enhance the transmission of human immunodeficiency virus (HIV). Thus, screening for STIs is a routine component of primary HIV care. There are limited data for selective screening guidelines for genital mycoplasmas and Chlamydia trachomatis in HIV-infected adults. The aim of the present study was to determine the frequency of genital infections with Ureaplasma spp., Mycoplasma hominis, M. genitalium and C. trachomatis in treatment naïve asymptomatic HIV-1 - infected adults and study their association with CD4+ T-cell count. Methods: First-void urine samples were collected from 100 treatment-naïve HIV-1-infected adults and 50 healthy volunteers. C. trachomatis and M. genitalium were detected by polymerase chain reaction (PCR). Ureaplasma spp. and M. hominis were detected by both culture and PCR. Circulating CD4+ cell counts of HIV-1-infected patients were determined from peripheral blood by flow-cytometry. Results: C. trachomatis was detected in 7 per cent of HIV-1-infected adults compared to none in control population. Ureaplasma spp. and M. hominis showed infection rates of 6 and 1 per cent in the HIV group and 2 and 0 per cent in the control group, respectively. None of the individuals from the patient and control groups was tested positive for M. genitalium. A significant association was found between CD4 cell count and detection of C. trachomatis in HIV-infected adults (P = 0.01). Interpretation & conclusions: Screening of HIV-infected individuals for C. trachomatis infection could be recommended as a routine component of HIV care. The role of mycoplasmas as co-pathogens of the genitourinary tract in HIV-1 infected patients seems to be unlikely. Further longitudinal studies need to be done to confirm these findings. PMID:22310829

  18. 'We didn't have to dance around it': opt-out HIV testing among homeless and marginalised patients.

    PubMed

    Leidel, Stacy; Leslie, Gavin; Boldy, Duncan; Davies, Andrew; Girdler, Sonya

    2017-07-01

    This study explored opt-out HIV testing in an Australian general practice. The aims were to: (1) determine the effect of the opt-out approach on the number of HIV tests performed; and (2) explore the acceptability of opt-out HIV testing from the healthcare providers' perspective. A prospective mixed-methods study of opt-out HIV testing over a 2-year period (March 2014-March 2016) was conducted. Implementation was based on a theoretical framework that was developed specifically for this study. The setting was Homeless Healthcare, a health service in Perth, Western Australia. The number of HIV tests conducted during the control year (usual practice) was compared with the intervention year (opt-out testing). After the intervention, the healthcare providers (n=8) were interviewed about their experiences with opt-out HIV testing. Directed content analysis was used to explore the qualitative data. HIV testing rates were low during both the control year and the intervention year (315 HIV tests (12% of the patient cohort) and 344 HIV tests (10%) respectively). Opt-out HIV testing was feasible and acceptable to the participating healthcare providers. Other health services could consider opt-out HIV testing for their patients to identify people with undiagnosed infections and sustain Australia's low HIV prevalence.

  19. Gut Microbiota Linked to Sexual Preference and HIV Infection

    PubMed Central

    Noguera-Julian, Marc; Rocafort, Muntsa; Guillén, Yolanda; Rivera, Javier; Casadellà, Maria; Nowak, Piotr; Hildebrand, Falk; Zeller, Georg; Parera, Mariona; Bellido, Rocío; Rodríguez, Cristina; Carrillo, Jorge; Mothe, Beatriz; Coll, Josep; Bravo, Isabel; Estany, Carla; Herrero, Cristina; Saz, Jorge; Sirera, Guillem; Torrela, Ariadna; Navarro, Jordi; Crespo, Manel; Brander, Christian; Negredo, Eugènia; Blanco, Julià; Guarner, Francisco; Calle, Maria Luz; Bork, Peer; Sönnerborg, Anders; Clotet, Bonaventura; Paredes, Roger

    2016-01-01

    The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. In two independent cohorts of HIV-1-infected subjects and HIV-1-negative controls in Barcelona (n = 156) and Stockholm (n = 84), men who have sex with men (MSM) predominantly belonged to the Prevotella-rich enterotype whereas most non-MSM subjects were enriched in Bacteroides, independently of HIV-1 status, and with only a limited contribution of diet effects. Moreover, MSM had a significantly richer and more diverse fecal microbiota than non-MSM individuals. After stratifying for sexual orientation, there was no solid evidence of an HIV-specific dysbiosis. However, HIV-1 infection remained consistently associated with reduced bacterial richness, the lowest bacterial richness being observed in subjects with a virological-immune discordant response to antiretroviral therapy. Our findings indicate that HIV gut microbiome studies must control for HIV risk factors and suggest interventions on gut bacterial richness as possible novel avenues to improve HIV-1-associated immune dysfunction. PMID:27077120

  20. Implementing a routine, voluntary HIV testing program in a Massachusetts county prison.

    PubMed

    Liddicoat, Rebecca V; Zheng, Hui; Internicola, Jeanne; Werner, Barbara G; Kazianis, Arthur; Golan, Yoav; Rubinstein, Eric P; Freedberg, Kenneth A; Walensky, Rochelle P

    2006-11-01

    Although U.S. prison inmates have higher rates of HIV infection than the general population, most inmates are not routinely tested for HIV infection at prison entry. The study objective was to implement a routine, voluntary HIV testing program in a Massachusetts county prison. During admission, inmates were given group HIV pre-test counseling and were subsequently offered private HIV testing. This intervention was compared to a control period during which HIV testing was provided only upon inmate or physician request. Between November 2004 and April 2005, 1,004 inmates met inclusion criteria and were offered routine, voluntary HIV testing. Of these, 734 (73.1%) accepted, 2 (0.3%) were HIV-infected, and 457 (45.5%) had been tested for HIV in the previous year. The testing rate of 73.1% was significantly increased from the rate of 18.0% (318 of 1,723) during the control period (p<0.001). Among the inmates tested for HIV in the prior year, 78.2% had received their last HIV test in the prison setting. Careful attention should be paid to prevent redundancy of testing efforts in the prison population. Implementing a routine HIV testing program among prison inmates greatly increased testing rates compared to on-request testing.

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