Solid motor diagnostic instrumentation. [design of self-contained instrumentation

NASA Technical Reports Server (NTRS)

Nakamura, Y.; Arens, W. E.; Wuest, W. S.

1973-01-01

A review of typical surveillance and monitoring practices followed during the flight phases of representative solid-propellant upper stages and apogee motors was conducted to evaluate the need for improved flight diagnostic instrumentation on future spacecraft. The capabilities of the flight instrumentation package were limited to the detection of whether or not the solid motor was the cause of failure and to the identification of probable primary failure modes. Conceptual designs of self-contained flight instrumentation packages capable of meeting these reqirements were generated and their performance, typical cost, and unit characteristics determined. Comparisons of a continuous real time and a thresholded hybrid design were made on the basis of performance, mass, power, cost, and expected life. The results of this analysis substantiated the feasibility of a self-contained independent flight instrumentation module as well as the existence of performance margins by which to exploit growth option applications.

Atmospheric, Magnetospheric and Plasmas in Space (AMPS) spacelab payload definition study - program analysis and planning for phase C/D document - Volume 7

NASA Technical Reports Server (NTRS)

Keeley, J. T.

1976-01-01

Typical missions identified for AMPS flights in the arly 1980's are described. Experiment objectives and typical scientific instruments selected to accomplish these objectives are discussed along with mission requirements and shuttle and Spacelab capabilities assessed to determine any AMPS unique requirements. Preliminary design concepts for the first two AMPS flights form the basis for the Phase C/D program plan. This plan implements flights 1 and 2 and indicates how both the scientific and flight support hardware can be systematically evolved for future AMPS flights.

Theoretical basis for design of thermal-stress-free fasteners

NASA Technical Reports Server (NTRS)

Blosser, M. L.; Mcwithey, R. R.

1983-01-01

A theoretical basis was developed for the design of fasteners which are free of thermal stress. A fastener can be shaped to eliminate the thermal stress which would otherwise result from differential thermal expansion between dissimilar fastener and sheet materials for many combinations of isotropic and orthotropic materials. The resulting joint remains snug, yet free of thermal stress at any temperature, if the joint is uniform in temperature, if it is frictionless, and if the coefficients of thermal expansion of the materials do not change with temperature. In general, such a fastener has curved sides; however, if both materials have isotropic coefficients of thermal expansion, a conical fastener is free of thermal stress. Equations are presented for thermal stress free shapes at both initial and final temperature, and typical fastener shapes are shown.

Simulation and Flight Control of an Aeroelastic Fixed Wing Micro Aerial Vehicle

NASA Technical Reports Server (NTRS)

Waszak, Martin; Davidson, John B.; Ifju, Peter G.

2002-01-01

Micro aerial vehicles have been the subject of continued interest and development over the last several years. The majority of current vehicle concepts rely on rigid fixed wings or rotors. An alternate design based on an aeroelastic membrane wing has also been developed that exhibits desired characteristics in flight test demonstrations, competition, and in prior aerodynamics studies. This paper presents a simulation model and an assessment of flight control characteristics of the vehicle. Linear state space models of the vehicle associated with typical trimmed level flight conditions and which are suitable for control system design are presented as well. The simulation is used as the basis for the design of a measurement based nonlinear dynamic inversion control system and outer loop guidance system. The vehicle/controller system is the subject of ongoing investigations of autonomous and collaborative control schemes. The results indicate that the design represents a good basis for further development of the micro aerial vehicle for autonomous and collaborative controls research.

Space vehicle integrated thermal protection/structural/meteoroid protection system, volume 1

NASA Technical Reports Server (NTRS)

Bartlett, D. H.; Zimmerman, D. K.

1973-01-01

A program was conducted to determine the merit of a combined structure/thermal meteoroid protection system for a cryogenic vehicle propulsion module. Structural concepts were evaluated to identify least weight designs. Thermal analyses determined optimum tank arrangements and insulation materials. Meteoroid penetration experiments provided data for design of protection systems. Preliminary designs were made and compared on the basis of payload capability. Thermal performance tests demonstrated heat transfer rates typical for the selected design. Meteoroid impact tests verified the protection characteristics. A mockup was made to demonstrate protection system installation. The best design found combined multilayer insulation with a truss structure vehicle body. The multilayer served as the thermal/meteoroid protection system.

Generalized adjustment by least squares ( GALS).

USGS Publications Warehouse

Elassal, A.A.

1983-01-01

The least-squares principle is universally accepted as the basis for adjustment procedures in the allied fields of geodesy, photogrammetry and surveying. A prototype software package for Generalized Adjustment by Least Squares (GALS) is described. The package is designed to perform all least-squares-related functions in a typical adjustment program. GALS is capable of supporting development of adjustment programs of any size or degree of complexity. -Author

Performance of single-stage compressor designed on basis of constant total enthalpy with symmetrical velocity diagram at all radii and velocity ratio of 0.7 at rotor hub / Jack R. Burtt and Robert J. Jackson

NASA Technical Reports Server (NTRS)

Burtt, Jack R; Jackson, Robert J

1951-01-01

A typical inlet axial-flow compressor inlet stage, which was designed on the basis of constant total enthalpy with symmetrical velocity diagram at all radii, was investigated. At a tip speed of 1126 feet per second, a peak pressure ratio of 1.28 was obtained at an efficiency of 0.76. At a tip speed, the highest practical flow was 28 pounds per second per square foot frontal area with an efficiency of 0.78. Data for a rotor relative inlet Mach number range of from 0.5 to 0.875 indicates that the critical value for any stage radial element is approximately 0.80 for the stage investigated.

Installation Restoration Program. Phase 1 - Records Search, Homestead AFB, Florida

DTIC Science & Technology

1983-08-01

con- ducted on a weekly basis. Since the early 1970’s, water and Aqueous . Film Forming Foam ( AFFF ) have been the main extinguishing agents used. Fuels...were occasionally disposed of at the site. Typically, water and AFFF were used as fire extinguishing agents. The site received a HARM score of 66. This...project activities include designs for Owens-Corning Fiberglas; 36,000 gpm neutralization facilities for FC Corporation; wastewater reclamation facilities

Design Life Level: Quantifying risk in a changing climate

NASA Astrophysics Data System (ADS)

Rootzén, Holger; Katz, Richard W.

2013-09-01

In the past, the concepts of return levels and return periods have been standard and important tools for engineering design. However, these concepts are based on the assumption of a stationary climate and do not apply to a changing climate, whether local or global. In this paper, we propose a refined concept, Design Life Level, which quantifies risk in a nonstationary climate and can serve as the basis for communication. In current practice, typical hydrologic risk management focuses on a standard (e.g., in terms of a high quantile corresponding to the specified probability of failure for a single year). Nevertheless, the basic information needed for engineering design should consist of (i) the design life period (e.g., the next 50 years, say 2015-2064); and (ii) the probability (e.g., 5% chance) of a hazardous event (typically, in the form of the hydrologic variable exceeding a high level) occurring during the design life period. Capturing both of these design characteristics, the Design Life Level is defined as an upper quantile (e.g., 5%) of the distribution of the maximum value of the hydrologic variable (e.g., water level) over the design life period. We relate this concept and variants of it to existing literature and illustrate how they, and some useful complementary plots, may be computed and used. One practically important consideration concerns quantifying the statistical uncertainty in estimating a high quantile under nonstationarity.

Surgeon Design Interface for Patient-Specific Concentric Tube Robots

PubMed Central

Morimoto, Tania K.; Greer, Joseph D.; Hsieh, Michael H.; Okamura, Allison M.

2017-01-01

Concentric tube robots have potential for use in a wide variety of surgical procedures due to their small size, dexterity, and ability to move in highly curved paths. Unlike most existing clinical robots, the design of these robots can be developed and manufactured on a patient- and procedure-specific basis. The design of concentric tube robots typically requires significant computation and optimization, and it remains unclear how the surgeon should be involved. We propose to use a virtual reality-based design environment for surgeons to easily and intuitively visualize and design a set of concentric tube robots for a specific patient and procedure. In this paper, we describe a novel patient-specific design process in the context of the virtual reality interface. We also show a resulting concentric tube robot design, created by a pediatric urologist to access a kidney stone in a pediatric patient. PMID:28656124

Surgeon Design Interface for Patient-Specific Concentric Tube Robots.

PubMed

Morimoto, Tania K; Greer, Joseph D; Hsieh, Michael H; Okamura, Allison M

2016-06-01

Concentric tube robots have potential for use in a wide variety of surgical procedures due to their small size, dexterity, and ability to move in highly curved paths. Unlike most existing clinical robots, the design of these robots can be developed and manufactured on a patient- and procedure-specific basis. The design of concentric tube robots typically requires significant computation and optimization, and it remains unclear how the surgeon should be involved. We propose to use a virtual reality-based design environment for surgeons to easily and intuitively visualize and design a set of concentric tube robots for a specific patient and procedure. In this paper, we describe a novel patient-specific design process in the context of the virtual reality interface. We also show a resulting concentric tube robot design, created by a pediatric urologist to access a kidney stone in a pediatric patient.

Designing, Fabrication and Controlling Of Multipurpose3-DOF Robotic Arm

NASA Astrophysics Data System (ADS)

Nabeel, Hafiz Muhammad; Azher, Anum; Usman Ali, Syed M.; Wahab Mughal, Abdul

2013-12-01

In the present work, we have successfully designed and developed a 3-DOF articulated Robotic Arm capable of performing typical industrial tasks such as painting or spraying, assembling and handling automobiles parts and etc., in resemblance to a human arm. The mechanical assembly is designed on SOLIDWORKS and aluminum grade 6061 -T6 is used for its fabrication in order to reduce the structure weight. We have applied inverse kinematics to determine the joint angles, equations are fed into an efficient microcontroller ATMEGA16 which performs all the calculations to determine the joint angles on the basis of given coordinates to actuate the joints through motorized control. Good accuracy was obtained with quadrature optical encoders installed in each joint to achieve the desired position and a LabVIEW based GUI is designed to provide human machine interface.

[Advances in low impact development technology for urban stormwater management].

PubMed

Liu, Wen; Chen, Wei-ping; Peng, Chi

2015-06-01

Low impact development ( LID), as an innovative technology for stormwater management, is effective to mitigate urban flooding and to detain pollutants. This paper systemically introduced the LID technology system, and summarized the reduction effects of three typical LID facilities (i.e. , bio-retention, green roof and permeable pavement) on stormwater runoff and main pollutants in recent literature, as well as research outcomes and experiences of LID technology on model simulation, cost-benefit analysis and management system. On this basis, we analyzed the problems and limitations of current LID technology studies. Finally, some suggestions about future research directions, appropriate design and scientific management were put forth. This work intended to provide scientific basis and suggestions for widespread use and standard setting of LID technology in China by referencing overseas studies.

Study of inducer load and stress, volume 2

NASA Technical Reports Server (NTRS)

1972-01-01

A program of analysis, design, fabrication and testing has been conducted to develop computer programs for predicting rocket engine turbopump inducer hydrodynamic loading, stress magnitude and distribution, and vibration characteristics. Methods of predicting blade loading, stress, and vibration characteristics were selected from a literature search and used as a basis for the computer programs. An inducer, representative of typical rocket engine inducers, was designed, fabricated, and tested with special instrumentation selected to provide measurements of blade surface pressures and stresses. Data from the tests were compared with predicted values and the computer programs were revised as required to improve correlation. For Volume 1 see N71-20403. For Volume 2 see N71-20404.

Knowledge sifters in MDA technologies

NASA Astrophysics Data System (ADS)

Kravchenko, Yuri; Kursitys, Ilona; Bova, Victoria

2018-05-01

The article considers a new approach to efficient management of information processes on the basis of object models. With the help of special design tools, a generic and application-independent application model is created, and then the program is implemented in a specific development environment. At the same time, the development process is completely based on a model that must contain all the information necessary for programming. The presence of a detailed model provides the automatic creation of typical parts of the application, the development of which is amenable to automation.

Ion tracking in photocathode rf guns

NASA Astrophysics Data System (ADS)

Lewellen, John W.

2002-02-01

Projected next-generation linac-based light sources, such as PERL or the TESLA free-electron laser, generally assume, as essential components of their injector complexes, long-pulse photocathode rf electron guns. These guns, due to their design rf pulse durations of many milliseconds to continuous wave, may be more susceptible to ion bombardment damage of their cathodes than conventional rf guns, which typically use rf pulses of microsecond duration. This paper explores this possibility in terms of ion propagation within the gun, and presents a basis for future study of the subject.

Economical Development of Complex Computer Systems

DTIC Science & Technology

1992-08-15

margins typically encountered in the ........ beginning of a product’s life cycle, and shorten the payback period.4 leS D ~~~~LC~~~ Jr4.tt L~s.c...recurring, and other related costsincurred, or estimated to be incurr in the design, research and development (R& D ), investment, operation, maintenance...on the basis of cost. D E C R ’Item I E Incorporatento A-ml S .... .. EF D Y ..... S F R Technology& : Recnser 0 N P T Item N A -- Y E -- B N ’’A D

Design, Fabrication, Testing, and Installation of a Press-Lam Bridge.

DTIC Science & Technology

1979-01-01

lild components Alt eneers specific gravity, and ring count (table 11 INA NA NI In Douglas-fir logs of these diameters . the width of sapwood is...typically small, dram .’, 14 I 17 , I to 3 inches The moisture content t , I 4S 9 40 4 (ovendry basis) of sapwood was as high I t, . as 140 percent... sapwood and heartwood Veneers having greater lest maleital 1 196 veneer, brilte i mnonents :. I oeneem ttalW eets Itraded S 4;6 than 25 percent sapwood

An all-at-once reduced Hessian SQP scheme for aerodynamic design optimization

NASA Technical Reports Server (NTRS)

Feng, Dan; Pulliam, Thomas H.

1995-01-01

This paper introduces a computational scheme for solving a class of aerodynamic design problems that can be posed as nonlinear equality constrained optimizations. The scheme treats the flow and design variables as independent variables, and solves the constrained optimization problem via reduced Hessian successive quadratic programming. It updates the design and flow variables simultaneously at each iteration and allows flow variables to be infeasible before convergence. The solution of an adjoint flow equation is never needed. In addition, a range space basis is chosen so that in a certain sense the 'cross term' ignored in reduced Hessian SQP methods is minimized. Numerical results for a nozzle design using the quasi-one-dimensional Euler equations show that this scheme is computationally efficient and robust. The computational cost of a typical nozzle design is only a fraction more than that of the corresponding analysis flow calculation. Superlinear convergence is also observed, which agrees with the theoretical properties of this scheme. All optimal solutions are obtained by starting far away from the final solution.

Magic Mirror, On the Wall-Which Is the Right Study Design of Them All?-Part II.

PubMed

Vetter, Thomas R

2017-07-01

The assessment of a new or existing treatment or other intervention typically answers 1 of 3 central research-related questions: (1) "Can it work?" (efficacy); (2) "Does it work?" (effectiveness); or (3) "Is it worth it?" (efficiency or cost-effectiveness). There are a number of study designs that, on a situational basis, are appropriate to apply in conducting research. These study designs are generally classified as experimental, quasiexperimental, or observational, with observational studies being further divided into descriptive and analytic categories. This second of a 2-part statistical tutorial reviews these 3 salient research questions and describes a subset of the most common types of observational study designs. Attention is focused on the strengths and weaknesses of each study design to assist in choosing which is appropriate for a given study objective and hypothesis as well as the particular study setting and available resources and data. Specific studies and papers are highlighted as examples of a well-chosen, clearly stated, and properly executed study design type.

Magic Mirror, on the Wall-Which Is the Right Study Design of Them All?-Part I.

PubMed

Vetter, Thomas R

2017-06-01

The assessment of a new or existing treatment or intervention typically answers 1 of 3 research-related questions: (1) "Can it work?" (efficacy); (2) "Does it work?" (effectiveness); and (3) "Is it worth it?" (efficiency or cost-effectiveness). There are a number of study designs that on a situational basis are appropriate to apply in conducting research. These study designs are classified as experimental, quasi-experimental, or observational, with observational studies being further divided into descriptive and analytic categories. This first of a 2-part statistical tutorial reviews these 3 salient research questions and describes a subset of the most common types of experimental and quasi-experimental study design. Attention is focused on the strengths and weaknesses of each study design to assist in choosing which is appropriate for a given study objective and hypothesis as well as the particular study setting and available resources and data. Specific studies and papers are highlighted as examples of a well-chosen, clearly stated, and properly executed study design type.

Causal inference, probability theory, and graphical insights.

PubMed

Baker, Stuart G

2013-11-10

Causal inference from observational studies is a fundamental topic in biostatistics. The causal graph literature typically views probability theory as insufficient to express causal concepts in observational studies. In contrast, the view here is that probability theory is a desirable and sufficient basis for many topics in causal inference for the following two reasons. First, probability theory is generally more flexible than causal graphs: Besides explaining such causal graph topics as M-bias (adjusting for a collider) and bias amplification and attenuation (when adjusting for instrumental variable), probability theory is also the foundation of the paired availability design for historical controls, which does not fit into a causal graph framework. Second, probability theory is the basis for insightful graphical displays including the BK-Plot for understanding Simpson's paradox with a binary confounder, the BK2-Plot for understanding bias amplification and attenuation in the presence of an unobserved binary confounder, and the PAD-Plot for understanding the principal stratification component of the paired availability design. Published 2013. This article is a US Government work and is in the public domain in the USA.

Zernike-like systems in polygons and polygonal facets.

PubMed

Ferreira, Chelo; López, José L; Navarro, Rafael; Sinusía, Ester Pérez

2015-07-20

Zernike polynomials are commonly used to represent the wavefront phase on circular optical apertures, since they form a complete and orthonormal basis on the unit disk. In [Opt. Lett.32, 74 (2007)10.1364/OL.32.000074OPLEDP0146-9592] we introduced a new Zernike basis for elliptic and annular optical apertures based on an appropriate diffeomorphism between the unit disk and the ellipse and the annulus. Here, we present a generalization of this Zernike basis for a variety of important optical apertures, paying special attention to polygons and the polygonal facets present in segmented mirror telescopes. On the contrary to ad hoc solutions, most of them based on the Gram-Smith orthonormalization method, here we consider a piecewise diffeomorphism that transforms the unit disk into the polygon under consideration. We use this mapping to define a Zernike-like orthonormal system over the polygon. We also consider ensembles of polygonal facets that are essential in the design of segmented mirror telescopes. This generalization, based on in-plane warping of the basis functions, provides a unique solution, and what is more important, it guarantees a reasonable level of invariance of the mathematical properties and the physical meaning of the initial basis functions. Both the general form and the explicit expressions for a typical example of telescope optical aperture are provided.

Modeling and optimization of a typical fuel cell-heat engine hybrid system and its parametric design criteria

NASA Astrophysics Data System (ADS)

Zhao, Yingru; Chen, Jincan

A theoretical modeling approach is presented, which describes the behavior of a typical fuel cell-heat engine hybrid system in steady-state operating condition based on an existing solid oxide fuel cell model, to provide useful fundamental design characteristics as well as potential critical problems. The different sources of irreversible losses, such as the electrochemical reaction, electric resistances, finite-rate heat transfer between the fuel cell and the heat engine, and heat-leak from the fuel cell to the environment are specified and investigated. Energy and entropy analyses are used to indicate the multi-irreversible losses and to assess the work potentials of the hybrid system. Expressions for the power output and efficiency of the hybrid system are derived and the performance characteristics of the system are presented and discussed in detail. The effects of the design parameters and operating conditions on the system performance are studied numerically. It is found that there exist certain optimum criteria for some important parameters. The results obtained here may provide a theoretical basis for both the optimal design and operation of real fuel cell-heat engine hybrid systems. This new approach can be easily extended to other fuel cell hybrid systems to develop irreversible models suitable for the investigation and optimization of similar energy conversion settings and electrochemistry systems.

"Smoke": Characterization Of Smoke Particulate For Spacecraft Fire Detection

NASA Technical Reports Server (NTRS)

Urban, David L.; Mulholland, George W.; Yang, Jiann; Cleary, Thomas G.; Yuan, Zeng-Guang

2003-01-01

The "Smoke" experiment is a flight definition investigation that seeks to increase our understanding of spacecraft fire detection through measurements of particulate size distributions of preignition smokes from typical spacecraft materials. Owing to the catastrophic risk posed by even a very small fire in a spacecraft, the design goal for spacecraft fire detection is to detect the fire as quickly as possible, preferably in the preignition phase before a real flaming fire has developed. Consequently the target smoke for detection is typically not soot (typical of established hydrocarbon fires) but instead, pyrolysis products, and recondensed polymer particles. At the same time, false alarms are extremely costly as the crew and the ground team must respond quickly to every alarm. The U.S. Space Shuttle (STS: Space Transportation System) and the International Space Station (ISS) both use smoke detection as the primary means of fire detection. These two systems were designed in the absence of any data concerning low-gravity smoke particle (and background dust) size distributions. The STS system uses an ionization detector coupled with a sampling pump and the ISS system is a forward light scattering detector operating in the near IR. These two systems have significantly different sensitivities with the ionization detector being most sensitive (on a mass concentration basis) to smaller particulate and the light scattering detector being most sensitive to particulate that is larger than 1 micron. Since any smoke detection system has inherent size sensitivity characteristics, proper design of future smoke detection systems will require an understanding of the background and alarm particle size distributions that can be expected in a space environment.

The Design of Case Products’ Shape Form Information Database Based on NURBS Surface

NASA Astrophysics Data System (ADS)

Liu, Xing; Liu, Guo-zhong; Xu, Nuo-qi; Zhang, Wei-she

2017-07-01

In order to improve the computer design of product shape design,applying the Non-uniform Rational B-splines(NURBS) of curves and surfaces surface to the representation of the product shape helps designers to design the product effectively.On the basis of the typical product image contour extraction and using Pro/Engineer(Pro/E) to extract the geometric feature of scanning mold,in order to structure the information data base system of value point,control point and node vector parameter information,this paper put forward a unified expression method of using NURBS curves and surfaces to describe products’ geometric shape and using matrix laboratory(MATLAB) to simulate when products have the same or similar function.A case study of electric vehicle’s front cover illustrates the access process of geometric shape information of case product in this paper.This method can not only greatly reduce the capacity of information debate,but also improve the effectiveness of computer aided geometric innovation modeling.

Flow in a centrifugal fan impeller at off-design conditions

NASA Astrophysics Data System (ADS)

Wright, T.; Tzou, K. T. S.; Madhavan, S.

1984-06-01

A fully three-dimensional finite element analysis of inviscid, incompressible blade channel flow is the basis of the present study of both predicted and measured surface velocity and pressure distributions in the internal flow channels of a centrifugal fan impeller, for volume flow rates of 80-125 percent the design flow rate. The experimental results made extensive use of blade and sidewall surface pressure taps installed in a scale model of an airfoil-bladed centrifugal fan impeller. The results obtained illustrate the ability of both flow analyses to predict the dominant features of the impeller flow field, including peak blade surface velocities and adverse gradients at flows far from the design point. Insight is also gained into the limiting channel diffusion values for typical centrifugal cascade performance, together with the influence of viscous effects, as seen in deviations from ideal flow predictions.

Cost estimates and economic evaluations for conceptual LLRW disposal facility designs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baird, R.D.; Chau, N.; Breeds, C.D.

1995-12-31

Total life-cycle costs were estimated in support of the New York LLRW Siting Commission`s project to select a disposal method from four near-surface LLRW disposal methods (namely, uncovered above-grade vaults, covered above-grade vaults, below-grade vaults, and augered holes) and two mined methods (namely, vertical shaft mines and drift mines). Conceptual designs for the disposal methods were prepared and used as the basis for the cost estimates. Typical economic performance of each disposal method was assessed. Life-cycle costs expressed in 1994 dollars ranged from $ 1,100 million (for below-grade vaults and both mined disposal methods) to $2,000 million (for augered holes).more » Present values ranged from $620 million (for below-grade vaults) to $ 1,100 million (for augered holes).« less

A design for an intelligent monitor and controller for space station electrical power using parallel distributed problem solving

NASA Technical Reports Server (NTRS)

Morris, Robert A.

1990-01-01

The emphasis is on defining a set of communicating processes for intelligent spacecraft secondary power distribution and control. The computer hardware and software implementation platform for this work is that of the ADEPTS project at the Johnson Space Center (JSC). The electrical power system design which was used as the basis for this research is that of Space Station Freedom, although the functionality of the processes defined here generalize to any permanent manned space power control application. First, the Space Station Electrical Power Subsystem (EPS) hardware to be monitored is described, followed by a set of scenarios describing typical monitor and control activity. Then, the parallel distributed problem solving approach to knowledge engineering is introduced. There follows a two-step presentation of the intelligent software design for secondary power control. The first step decomposes the problem of monitoring and control into three primary functions. Each of the primary functions is described in detail. Suggestions for refinements and embelishments in design specifications are given.

Dietary guidelines in the Czech Republic. II.: Nutritional profiles of food groups.

PubMed

Brázdová, Z; Fiala, J; Bauerová, J; Mullerová, D

2000-11-01

Modern dietary guidelines set in terms of food groups are easy to use and understand for target populations, but rather complicated from the point of view of quantification, i.e. the correctly set number of recommended servings in different population groups according to age, sex, physical activity and physiological status on the basis of required intake of energy and individual nutrients. It is the use of abstract comprehensive food groups that makes it impossible to use a simple database of food tables based on the content of nutrients in individual foods, rather than their groups. Using groups requires that their nutritional profiles be established, i.e. that an average content of nutrients and energy for individual groups be calculated. To calculate nutritional profiles for Czech dietary guidelines, the authors used three different methods: (1) Simple profiles, with all commodities with significant representation in the Czech food basket represented in equal amounts. (2) Profiles based on typical servings, with the same commodities as in (1) but in characteristic intake quantities (typical servings). (3) Food basket-based profiles with commodities constituting the Czech food basket in quantities identical for that basket. The results showed significant differences in profiles calculated by different methods. Calculated nutrient intakes were particularly influenced by the size of typical servings and it is therefore essential that a realistic size of servings be used in calculations. The consistent use of recommended food items throughout all food groups and subgroups is very important. The number of servings of foods from the five food groups is not enough if a suitable food item is not chosen within individual groups. On the basis of their findings, the authors fully recommend the use of nutritional profiles based on typical servings that give a realistic idea of the probable energy and nutrient content in the recommended daily intake. In view of regional cultural differences, national nutritional profiles play a vital importance. Population studies investigating the size of the typical servings and the most frequently occurring commodities in the food basket should be made every three years. Nutritional profiles designed in this way constitute an important starting point for setting national dietary guidelines, their implementation and revisions.

Heteroatom-bridged benzothiazolyls for organic solar cells: a theoretical study.

PubMed

Chen, Runfeng; Wang, Yang; Chen, Ting; Li, Huanhuan; Zheng, Chunhua; Yuan, Kai; Wang, Zhixiang; Tao, Ye; Zheng, Chao; Huang, Wei

2015-01-15

On the basis of a typical organic photovoltaic (OPV) building block of 4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole (DTBT), a series of novel DTBT derivatives were designed following a heteroatom-bridging strategy to take advantage of the diversified interactions between heteroatoms and π-conjugated systems. These heteroatom-bridged DTBTs, whose outer electron-rich thiophene moieties are covalently fastened to the central electron-deficient benzothiadiazole with additional heteroatom bridges, exhibit promising features for OPV applications with rigid molecular structures, properly lain frontier molecular orbitals (FMOs), broad and intense absorption spectra, and adequate charge transport properties, as revealed by systematic theoretical calculations on molecular geometries, FMOs, absorption spectra, and relaxation and reorganization energies. The structure-property relationship investigations show that the mono-/di-heteroatom bridging is effective not only in tuning the rigidity of the molecular geometries but also in adjusting the optoelectronic properties of the resulting materials. Among the studied heteroatoms, the C and Si were found to be the most efficient in designing novel molecules for OPV applications. These theoretical insights may provide a solid basis for experimental synthesis and device investigations of the proposed heteroatom-bridged DTBTs as potential high-performance building blocks for bulk heterojunction OPV molecules.

Optical properties of micromachined polysilicon reflective surfaces with etching holes

NASA Astrophysics Data System (ADS)

Zou, Jun; Byrne, Colin; Liu, Chang; Brady, David J.

1998-08-01

MUMPS (Multi-User MEMS Process) is receiving increasingly wide use in micro optics. We have investigated the optical properties of the polysilicon reflective surface in a typical MUMPS chip within the visible light spectrum. The effect of etching holes on the reflected laser beam is studied. The reflectivity and diffraction patterns at five different wavelengths have been measured. The optical properties of the polysilicon reflective surface are greatly affected by the surface roughness, the etching holes, as well as the material. The etching holes contribute to diffraction and reduction of reflectivity. This study provides a basis for optimal design of micromachined free-space optical systems.

A Sequential Optimization Sampling Method for Metamodels with Radial Basis Functions

PubMed Central

Pan, Guang; Ye, Pengcheng; Yang, Zhidong

2014-01-01

Metamodels have been widely used in engineering design to facilitate analysis and optimization of complex systems that involve computationally expensive simulation programs. The accuracy of metamodels is strongly affected by the sampling methods. In this paper, a new sequential optimization sampling method is proposed. Based on the new sampling method, metamodels can be constructed repeatedly through the addition of sampling points, namely, extrema points of metamodels and minimum points of density function. Afterwards, the more accurate metamodels would be constructed by the procedure above. The validity and effectiveness of proposed sampling method are examined by studying typical numerical examples. PMID:25133206

Conic section function neural network circuitry for offline signature recognition.

PubMed

Erkmen, Burcu; Kahraman, Nihan; Vural, Revna A; Yildirim, Tulay

2010-04-01

In this brief, conic section function neural network (CSFNN) circuitry was designed for offline signature recognition. CSFNN is a unified framework for multilayer perceptron (MLP) and radial basis function (RBF) networks to make simultaneous use of advantages of both. The CSFNN circuitry architecture was developed using a mixed mode circuit implementation. The designed circuit system is problem independent. Hence, the general purpose neural network circuit system could be applied to various pattern recognition problems with different network sizes on condition with the maximum network size of 16-16-8. In this brief, CSFNN circuitry system has been applied to two different signature recognition problems. CSFNN circuitry was trained with chip-in-the-loop learning technique in order to compensate typical analog process variations. CSFNN hardware achieved highly comparable computational performances with CSFNN software for nonlinear signature recognition problems.

Classwide peer tutoring: an integration strategy to improve reading skills and promote peer interactions among students with autism and general education peers.

PubMed Central

Kamps, D M; Barbetta, P M; Leonard, B R; Delquadri, J

1994-01-01

A multiple baseline design across subjects with a reversal was used to examine the effects of classwide peer tutoring relative to traditional reading instruction on reading skills and social interaction time for 3 high-functioning students with autism and their typical peers in integrated, general education classrooms. Traditional reading instruction consisted largely of teacher-led instruction with individual student participation and seat work. Classwide peer tutoring consisted of 25 to 30 min of well-specified instruction in which tutor-learner pairs worked together on a classwide basis on reading fluency and comprehension skills. All students participated in 15- to 20-min unstructured free-time activities immediately following reading instruction. Results of reading assessments demonstrated that classwide peer tutoring increased reading fluency and correct responses to reading comprehension questions for students with autism and their peers. The procedure further increased the total duration of free-time social interactions for students with autism and typical peers, with individual variation in performance. PMID:8188563

RACE/A: an architectural account of the interactions between learning, task control, and retrieval dynamics.

PubMed

van Maanen, Leendert; van Rijn, Hedderik; Taatgen, Niels

2012-01-01

This article discusses how sequential sampling models can be integrated in a cognitive architecture. The new theory Retrieval by Accumulating Evidence in an Architecture (RACE/A) combines the level of detail typically provided by sequential sampling models with the level of task complexity typically provided by cognitive architectures. We will use RACE/A to model data from two variants of a picture-word interference task in a psychological refractory period design. These models will demonstrate how RACE/A enables interactions between sequential sampling and long-term declarative learning, and between sequential sampling and task control. In a traditional sequential sampling model, the onset of the process within the task is unclear, as is the number of sampling processes. RACE/A provides a theoretical basis for estimating the onset of sequential sampling processes during task execution and allows for easy modeling of multiple sequential sampling processes within a task. Copyright © 2011 Cognitive Science Society, Inc.

Lightning criteria relative to space shuttles: Currents and electric field intensity in Florida lightning

NASA Technical Reports Server (NTRS)

Uman, M. A.; Mclain, D. K.

1972-01-01

The measured electric field intensities of 161 lightning strokes in 39 flashes which occurred between 1 and 35 km from an observation point at Kennedy Space Center, Florida during June and July of 1971 have been analyzed to determine the lightning channel currents which produced the fields. In addition, typical channel currents are derived and from these typical electric fields at distances between 0.5 and 100 km are computed and presented. On the basis of the results recommendations are made for changes in the specification of lightning properties relative to space vehicle design as given in NASA TMX-64589 (Daniels, 1971). The small sample of lightning analyzed yielded several peak currents in the 100 kA range. Several current rise-times from zero to peak of 0.5 microsec or faster were found; and the fastest observed current rate-of-rise was near 200 kA/microsec. The various sources of error are discussed.

The construction of general basis functions in reweighting ensemble dynamics simulations: Reproduce equilibrium distribution in complex systems from multiple short simulation trajectories

NASA Astrophysics Data System (ADS)

Zhang, Chuan-Biao; Ming, Li; Xin, Zhou

2015-12-01

Ensemble simulations, which use multiple short independent trajectories from dispersive initial conformations, rather than a single long trajectory as used in traditional simulations, are expected to sample complex systems such as biomolecules much more efficiently. The re-weighted ensemble dynamics (RED) is designed to combine these short trajectories to reconstruct the global equilibrium distribution. In the RED, a number of conformational functions, named as basis functions, are applied to relate these trajectories to each other, then a detailed-balance-based linear equation is built, whose solution provides the weights of these trajectories in equilibrium distribution. Thus, the sufficient and efficient selection of basis functions is critical to the practical application of RED. Here, we review and present a few possible ways to generally construct basis functions for applying the RED in complex molecular systems. Especially, for systems with less priori knowledge, we could generally use the root mean squared deviation (RMSD) among conformations to split the whole conformational space into a set of cells, then use the RMSD-based-cell functions as basis functions. We demonstrate the application of the RED in typical systems, including a two-dimensional toy model, the lattice Potts model, and a short peptide system. The results indicate that the RED with the constructions of basis functions not only more efficiently sample the complex systems, but also provide a general way to understand the metastable structure of conformational space. Project supported by the National Natural Science Foundation of China (Grant No. 11175250).

LMI Based Robust Blood Glucose Regulation in Type-1 Diabetes Patient with Daily Multi-meal Ingestion

NASA Astrophysics Data System (ADS)

Mandal, S.; Bhattacharjee, A.; Sutradhar, A.

2014-04-01

This paper illustrates the design of a robust output feedback H ∞ controller for the nonlinear glucose-insulin (GI) process in a type-1 diabetes patient to deliver insulin through intravenous infusion device. The H ∞ design specification have been realized using the concept of linear matrix inequality (LMI) and the LMI approach has been used to quadratically stabilize the GI process via output feedback H ∞ controller. The controller has been designed on the basis of full 19th order linearized state-space model generated from the modified Sorensen's nonlinear model of GI process. The resulting controller has been tested with the nonlinear patient model (the modified Sorensen's model) in presence of patient parameter variations and other uncertainty conditions. The performance of the controller was assessed in terms of its ability to track the normoglycemic set point of 81 mg/dl with a typical multi-meal disturbance throughout a day that yields robust performance and noise rejection.

Spectromicroscopic insights for rational design of redox-based memristive devices

PubMed Central

Baeumer, Christoph; Schmitz, Christoph; Ramadan, Amr H. H.; Du, Hongchu; Skaja, Katharina; Feyer, Vitaliy; Müller, Philipp; Arndt, Benedikt; Jia, Chun-Lin; Mayer, Joachim; De Souza, Roger A.; Michael Schneider, Claus; Waser, Rainer; Dittmann, Regina

2015-01-01

The demand for highly scalable, low-power devices for data storage and logic operations is strongly stimulating research into resistive switching as a novel concept for future non-volatile memory devices. To meet technological requirements, it is imperative to have a set of material design rules based on fundamental material physics, but deriving such rules is proving challenging. Here, we elucidate both switching mechanism and failure mechanism in the valence-change model material SrTiO3, and on this basis we derive a design rule for failure-resistant devices. Spectromicroscopy reveals that the resistance change during device operation and failure is indeed caused by nanoscale oxygen migration resulting in localized valence changes between Ti4+ and Ti3+. While fast reoxidation typically results in retention failure in SrTiO3, local phase separation within the switching filament stabilizes the retention. Mimicking this phase separation by intentionally introducing retention-stabilization layers with slow oxygen transport improves retention times considerably. PMID:26477940

A Novel Amyloid Designable Scaffold and Potential Inhibitor Inspired by GAIIG of Amyloid Beta and the HIV-1 V3 loop.

PubMed

Kokotidou, C; Jonnalagadda, S V R; Orr, A A; Seoane-Blanco, M; Apostolidou, C P; van Raaij, M J; Kotzabasaki, M; Chatzoudis, A; Jakubowski, J M; Mossou, E; Forsyth, V T; Mitchell, E P; Bowler, M W; Llamas-Saiz, A L; Tamamis, P; Mitraki, A

2018-05-17

The GAIIG sequence, common to the amyloid beta peptide (residues 29-33) and to the HIV gp 120 (residues 24-28 in a typical V3 loop) self-assembles into amyloid fibrils, as suggested by theory and the experiments presented here. The longer YATGAIIGNII sequence from the V3 loop also self-assembles into amyloid fibrils, of which the first three and the last two residues are outside the amyloid GAIIG core. We postulate that this sequence, with suitable selected replacements at the flexible positions, can serve as a designable scaffold for novel amyloid-based materials. Moreover, we report the single X-ray crystal structure of the beta-breaker peptide GAIPIG at 1.05 Å resolution. This structural information could serve as the basis for structure-based design of potential inhibitors of amyloid formation. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Design, develop and test high temperature dynamic seals for the space shuttle's aerodynamic control surfaces

NASA Technical Reports Server (NTRS)

1973-01-01

A description is given of the design, development and testing of high temperature dynamic seals for the gaps between the structure and aerodynamic control surfaces on the space shuttle. These aerodynamic seals are required to prevent high temperature airflow from damaging thermally unprotected structures and components during entry. Two seal concepts evolved a curtain seal for the spanwise elevon cove gap, and a labyrinth seal for the area above the elevon, at the gap between the end of the elevon and the fuselage. On the basis of development testing, both seal concepts were shown to be feasible for controlling internal temperatures to 350 F or less when exposed to a typical space shuttle entry environment. The curtain seal concept demonstrated excellent test results and merits strong consideration for application on the space shuttle orbiter. The labyrinth seal concept, although demonstrating significant temperature reduction characteristics, may or may not be required on the Orbiter, depending on the actual design configuration and flight environment.

The early development of stereotypy and self-injury: a review of research methods.

PubMed

Symons, F J; Sperry, L A; Dropik, P L; Bodfish, J W

2005-02-01

The origin and developmental course of stereotypic and self-injurious behaviour among individuals with developmental disabilities such as intellectual disability (ID) or pervasive development disorders such as autism is not well understood. Twelve studies designed to document the prevalence, nature, or development of stereotypic and/or self-injurious behaviour in children under 5 years of age and identified as at risk for developmental delay or disability were reviewed. Comparisons were made with similar studies with typically developing children. It appears that the onset of naturally occurring rhythmic motor stereotypies is delayed in young at-risk children, but that the sequencing may be similar. A very small database, differences in samples, measures, and designs limited the degree to which comparisons could be made across studies. Future work is needed based on appropriately designed prospective comparison studies and uniform quantitative measures to provide an empirical basis for new knowledge about the early development of one of the most serious behaviour disorders afflicting children with ID and related problems of development.

Atypical and Typical Antipsychotics in the Schools

ERIC Educational Resources Information Center

Noggle, Chad A.; Dean, Raymond S.

2009-01-01

The use of antipsychotic medications within the school-age population is rapidly increasing. Although typical antipsychotics may be used in rare cases, this influx is largely secondary to the availability of the atypical antipsychotics. Reduction of possible adverse effects and increased efficacy represent the primary basis for the atypical…

Thermo-mechanical Design Methodology for ITER Cryodistribution cold boxes

NASA Astrophysics Data System (ADS)

Shukla, Vinit; Patel, Pratik; Das, Jotirmoy; Vaghela, Hitensinh; Bhattacharya, Ritendra; Shah, Nitin; Choukekar, Ketan; Chang, Hyun-Sik; Sarkar, Biswanath

2017-04-01

The ITER cryo-distribution (CD) system is in charge of proper distribution of the cryogen at required mass flow rate, pressure and temperature level to the users; namely the superconducting (SC) magnets and cryopumps (CPs). The CD system is also capable to use the magnet structures as a thermal buffer in order to operate the cryo-plant as much as possible at a steady state condition. A typical CD cold box is equipped with mainly liquid helium (LHe) bath, heat exchangers (HX’s), cryogenic valves, filter, heaters, cold circulator, cold compressor and process piping. The various load combinations which are likely to occur during the life cycle of the CD cold boxes are imposed on the representative model and impacts on the system are analyzed. This study shows that break of insulation vacuum during nominal operation (NO) along with seismic event (Seismic Level-2) is the most stringent load combination having maximum stress of 224 MPa. However, NO+SMHV (Séismes Maximaux Historiquement Vraisemblables = Maximum Historically Probable Earthquakes) load combination is having the least safety margin and will lead the basis of the design of the CD system and its sub components. This paper presents and compares the results of different load combinations which are likely to occur on a typical CD cold box.

Functional anatomy of the spine.

PubMed

Bogduk, Nikolai

2016-01-01

Among other important features of the functional anatomy of the spine, described in this chapter, is the remarkable difference between the design and function of the cervical spine and that of the lumbar spine. In the cervical spine, the atlas serves to transmit the load of the head to the typical cervical vertebrae. The axis adapts the suboccipital region to the typical cervical spine. In cervical intervertebrtal discs the anulus fibrosus is not circumferential but is crescentic, and serves as an interosseous ligament in the saddle joint between vertebral bodies. Cervical vertebrae rotate and translate in the sagittal plane, and rotate in the manner of an inverted cone, across an oblique coronal plane. The cervical zygapophysial joints are the most common source of chronic neck pain. By contrast, lumbar discs are well designed to sustain compression loads, but rely on posterior elements to limit axial rotation. Internal disc disruption is the most common basis for chronic low-back pain. Spinal muscles are arranged systematically in prevertebral and postvertebral groups. The intrinsic elements of the spine are innervated by the dorsal rami of the spinal nerves, and by the sinuvertebral nerves. Little modern research has been conducted into the structure of the thoracic spine, or the causes of thoracic spinal pain. © 2016 Elsevier B.V. All rights reserved.

Optimization of rotating equipment in offshore wind farm

NASA Astrophysics Data System (ADS)

Okunade, O. A.

2014-07-01

The paper considered the improvement of rotating equipment in a wind farm, and how these could maximise the farm power capacity. It aimed to increase capacity of electricity generation through a renewable source in UK and contribute to 15 per cent energy- consumption target, set by EU on electricity through renewable sources by 2020. With reference to a case study in UK offshore wind farm, the paper analysed the critique of the farm, as a design basis for its optimization. It considered power production as design situation, load cases and constraints, in order to reflect characteristics and behaviour of a standard design. The scope, which considered parts that were directly involved in power generation, covered rotor blades and the impacts of gearbox and generator to power generation. The scope did not however cover support structures like tower design. The approaches of detail data analysis of the blade at typical wind load conditions, were supported by data from acceptable design standards, relevant authorities and professional bodies. The findings in proposed model design showed at least over 3 per cent improvement on the existing electricity generation. It also indicated overall effects on climate change.

75 FR 22890 - Notice of Requests for Renewal of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... Management and Budget's (OMB) approval to renew an information collection. The collection involved here.... Mail or Hand Delivery: Docket Management Facility, U.S. Department of Transportation, 1200 New Jersey...,'' establishes the fundamental basis for paying these air carriers on a timely basis. Typically, subsidized air...

48 CFR 315.204-5 - Part IV-Representations and instructions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... as using too few.) (3) Examples of topics that form a basis for evaluation factors. Typical examples of topics that form a basis for the development of evaluation factors are listed in the following... special research, test, and other equipment or facilities. (vii) Managerial capability (ability to achieve...

48 CFR 315.204-5 - Part IV-Representations and instructions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... as using too few.) (3) Examples of topics that form a basis for evaluation factors. Typical examples of topics that form a basis for the development of evaluation factors are listed in the following... special research, test, and other equipment or facilities. (vii) Managerial capability (ability to achieve...

48 CFR 315.204-5 - Part IV-Representations and instructions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... as using too few.) (3) Examples of topics that form a basis for evaluation factors. Typical examples of topics that form a basis for the development of evaluation factors are listed in the following... special research, test, and other equipment or facilities. (vii) Managerial capability (ability to achieve...

Black light - How sensors filter spectral variation of the illuminant

NASA Technical Reports Server (NTRS)

Brainard, David H.; Wandell, Brian A.; Cowan, William B.

1989-01-01

Visual sensor responses may be used to classify objects on the basis of their surface reflectance functions. In a color image, the image data are represented as a vector of sensor responses at each point in the image. This vector depends both on the surface reflectance functions and on the spectral power distribution of the ambient illumination. Algorithms designed to classify objects on the basis of their surface reflectance functions typically attempt to overcome the dependence of the sensor responses on the illuminant by integrating sensor data collected from multiple surfaces. In machine vision applications, it is shown that it is often possible to design the sensor spectral responsivities so that the vector direction of the sensor responses does not depend upon the illuminant. The conditions under which this is possible are given and an illustrative calculation is performed. In biological systems, where the sensor responsivities are fixed, it is shown that some changes in the illumination cause no change in the sensor responses. Such changes in illuminant are called black illuminants. It is possible to express any illuminant as the sum of two unique components. One component is a black illuminant. The second component is called the visible component. The visible component of an illuminant completely characterizes the effect of the illuminant on the vector of sensor responses.

Propellant Mass Fraction Calculation Methodology for Launch Vehicles and Application to Ares Vehicles

NASA Technical Reports Server (NTRS)

Holt, James B.; Monk, Timothy S.

2009-01-01

Propellant Mass Fraction (pmf) calculation methods vary throughout the aerospace industry. While typically used as a means of comparison between candidate launch vehicle designs, the actual pmf calculation method varies slightly from one entity to another. It is the purpose of this paper to present various methods used to calculate the pmf of launch vehicles. This includes fundamental methods of pmf calculation that consider only the total propellant mass and the dry mass of the vehicle; more involved methods that consider the residuals, reserves and any other unusable propellant remaining in the vehicle; and calculations excluding large mass quantities such as the installed engine mass. Finally, a historical comparison is made between launch vehicles on the basis of the differing calculation methodologies, while the unique mission and design requirements of the Ares V Earth Departure Stage (EDS) are examined in terms of impact to pmf.

Passive coherent location direct signal suppression using hardware mixing techniques

NASA Astrophysics Data System (ADS)

Kaiser, Sean A.; Christianson, Andrew J.; Narayanan, Ram M.

2017-05-01

Passive coherent location (PCL) is a radar technique, in which the system uses reflections from opportunistic illumination sources in the environment for detection and tracking. Typically, PCL uses civilian communication transmitters not ideally suited for radar. The physical geometry of PCL is developed on the basis of bistatic radar without control of the transmitter antenna or waveform design. This poses the problem that often the receiver is designed with two antennas and channels, one for reference and one for surveillance. The surveillance channel is also contaminated with the direct signal and thus direct signal suppression (DSS) techniques must be used. This paper proposes an analytical solution based around hardware for DSS which is compared to other methods available in the literature. The methods are tested in varying bistatic geometries and with varying target radar cross section (RCS) and signal-to-noise ratio (SNR).

Identifying new technologies that save energy and reduce costs to the Federal sector: The New Technology Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, W.D.M.; Conover, D.R.; Stockmeyer, M.K.

1995-11-01

In 1990 the New Technology Demonstration Program (formerly the Test Bed Demonstration Program) was initiated by the US Department of Energy`s Office (DOE`s) of Federal Energy Management Programs with the purpose of accelerating the introduction of new technologies into the Federal sector. The program has since expanded into a multi-laboratory collaborative effort that evaluates new technologies and shares the results with the Federal design and procurement communities. These evaluations are performed on a collaborative basis which typically includes technology manufacturers, Federal facilities, utilities, trade associations, research institutes, and other in partnership with DOE. The end result is a range ofmore » effective technology transfer tools that provide operations and performance data on new technologies to Federal designers, building managers, and procurement officials. These tools assist in accelerating a technology`s Federal application and realizing reductions in energy consumption and costs.« less

[Myofascial pain syndrome--frequent occurrence and often misdiagnosed].

PubMed

Pongratz, D E; Späth, M

1998-09-30

Myofascial pain syndrome (MPS) is a very common localized--sometimes also polytopic--painful musculoskeletal condition associated with trigger points, for which, however, diagnostic criteria established in well-designed studies are still lacking. These two facts form the basis for differentiating between MPS and the fibromyalgia syndrome. The difference between trigger points (MPS) and tender points (fibromyalgia) is of central importance--not merely in a linguistic sense. A knowledge of the signs and symptoms typically associated with a trigger point often obviates the need for time-consuming and expensive technical diagnostic measures. The assumption that many cases of unspecific complaints affecting the musculoskeletal system may be ascribed to MPS makes clear the scope for the saving of costs.

[A magnetic therapy apparatus with an adaptable electromagnetic spectrum for the treatment of prostatitis and gynecopathies].

PubMed

Kuz'min, A A; Meshkovskiĭ, D V; Filist, S A

2008-01-01

Problems of engineering and algorithm development of magnetic therapy apparatuses with pseudo-random radiation spectrum within the audio range for treatment of prostatitis and gynecopathies are considered. A typical design based on a PIC 16F microcontroller is suggested. It includes a keyboard, LCD indicator, audio amplifier, inducer, and software units. The problem of pseudo-random signal generation within the audio range is considered. A series of rectangular pulses is generated on a random-length interval on the basis of a three-component random vector. This series provides the required spectral characteristics of the therapeutic magnetic field and their adaptation to the therapeutic conditions and individual features of the patient.

10 CFR 72.92 - Design basis external natural events.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics of...

10 CFR 72.92 - Design basis external natural events.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics of...

10 CFR 72.92 - Design basis external natural events.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics of...

Zombie algorithms: a timesaving remote sensing systems engineering tool

NASA Astrophysics Data System (ADS)

Ardanuy, Philip E.; Powell, Dylan C.; Marley, Stephen

2008-08-01

In modern horror fiction, zombies are generally undead corpses brought back from the dead by supernatural or scientific means, and are rarely under anyone's direct control. They typically have very limited intelligence, and hunger for the flesh of the living [1]. Typical spectroradiometric or hyperspectral instruments providess calibrated radiances for a number of remote sensing algorithms. The algorithms typically must meet specified latency and availability requirements while yielding products at the required quality. These systems, whether research, operational, or a hybrid, are typically cost constrained. Complexity of the algorithms can be high, and may evolve and mature over time as sensor characterization changes, product validation occurs, and areas of scientific basis improvement are identified and completed. This suggests the need for a systems engineering process for algorithm maintenance that is agile, cost efficient, repeatable, and predictable. Experience on remote sensing science data systems suggests the benefits of "plug-n-play" concepts of operation. The concept, while intuitively simple, can be challenging to implement in practice. The use of zombie algorithms-empty shells that outwardly resemble the form, fit, and function of a "complete" algorithm without the implemented theoretical basis-provides the ground systems advantages equivalent to those obtained by integrating sensor engineering models onto the spacecraft bus. Combined with a mature, repeatable process for incorporating the theoretical basis, or scientific core, into the "head" of the zombie algorithm, along with associated scripting and registration, provides an easy "on ramp" for the rapid and low-risk integration of scientific applications into operational systems.

The Basis of Feeling-of-Knowing Judgments in Patients with Schizophrenia

ERIC Educational Resources Information Center

Bacon, Elisabeth; Pillot, Mathieu; Izaute, Marie; Schwartz, Bennett L.

2018-01-01

We examined the basis of feeling-of-knowing judgments (FOK) in patients with schizophrenia. Such patients typically have impaired memory and awareness, but not metamemory-accuracy deficits. The magnitude of FOKs are lower for patients with schizophrenia than for healthy participants, but judgments equally predict memory performance. In healthy…

Sustaining a Community Computing Infrastructure for Online Teacher Professional Development: A Case Study of Designing Tapped In

NASA Astrophysics Data System (ADS)

Farooq, Umer; Schank, Patricia; Harris, Alexandra; Fusco, Judith; Schlager, Mark

Community computing has recently grown to become a major research area in human-computer interaction. One of the objectives of community computing is to support computer-supported cooperative work among distributed collaborators working toward shared professional goals in online communities of practice. A core issue in designing and developing community computing infrastructures — the underlying sociotechnical layer that supports communitarian activities — is sustainability. Many community computing initiatives fail because the underlying infrastructure does not meet end user requirements; the community is unable to maintain a critical mass of users consistently over time; it generates insufficient social capital to support significant contributions by members of the community; or, as typically happens with funded initiatives, financial and human capital resource become unavailable to further maintain the infrastructure. On the basis of more than 9 years of design experience with Tapped In-an online community of practice for education professionals — we present a case study that discusses four design interventions that have sustained the Tapped In infrastructure and its community to date. These interventions represent broader design strategies for developing online environments for professional communities of practice.

Hunger, inhibitory control and distress-induced emotional eating.

PubMed

van Strien, Tatjana; Ouwens, Machteld A; Engel, Carmen; de Weerth, Carolina

2014-08-01

Self-reported emotional eating has been found to significantly moderate distress-induced food intake, with low emotional eaters eating less after a stress task than after a control task and high emotional eaters eating more. The aim of the present study was to explore possible underlying mechanisms by assessing possible associations with (1) ability to experience the typical post-stress reduction of hunger and (2) inhibitory control. We studied these effects in 54 female students who were preselected on the basis of extremely high or low scores on an emotional eating questionnaire. Using a within subject design we measured the difference of actual food or snack intake after a control or a stress task (Trier Social Stress Test). As expected, the moderator effect of emotional eating on distress-induced food intake was found to be only present in females with a failure to report the typical reduction of hunger immediately after a stress task (an a-typical hunger stress response). Contrary to our expectations, this moderator effect of emotional eating was also found to be only present in females with high ability to stop motor impulses (high inhibitory control). These findings suggest that an a-typical hunger stress response but not poor inhibitory control may underlie the moderator effect of emotional eating on distress-induced food intake. However, inhibitory control may play a role whether or not there is a moderator effect of self-reported emotional eating on distress-induced food intake. Copyright © 2014 Elsevier Ltd. All rights reserved.

77 FR 64564 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

...-Basis Hurricane and Hurricane Missiles AGENCY: Nuclear Regulatory Commission. ACTION: Proposed interim...-ISG-024, ``Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles....221, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants.'' DATES: Submit...

Feasibility Analysis of Incorporating In-Vitro Toxicokinetic Data as a Surrogate for In-Vivo Data for Read-across Predictions (ASCCT meeting)

EPA Science Inventory

The underlying principle of read-across is that biological activity is a function of physical and structural properties of chemicals. Analogs are typically identified on the basis of structural similarity and subsequently evaluated for their use in read-across on the basis of the...

Directional guidance from audible pedestrian signals for street crossing.

PubMed

Wall, Robert S; Ashmead, Daniel H; Bentzen, Billie Louise; Barlow, Janet

2004-10-10

Typical audible pedestrian signals indicate when the pedestrian walk interval is in effect but provide little, or even misleading information for directional alignment. In three experiments, blind and blindfolded sighted adults crossed a simulated crossing with recorded traffic noise to approximate street sounds. This was done to investigate how characteristics of signal presentation affected usefulness of the auditory signal for guiding crossing behaviour. Crossing was more accurate when signals came only from the far end of the crossing rather than the typical practice of presenting signals simultaneously from both ends. Alternating the signal between ends of the crossing was not helpful. Also, the customary practice of signalling two parallel crossings at the same time drew participants somewhat toward the opposite crossing. Providing a locator tone at the end of the crossing during the pedestrian clearance interval improved crossing accuracy. These findings provide a basis for designing audible pedestrian signals to enhance directional guidance. The principal findings were the same for blind and sighted participants and applied across a range of specific signals (e.g. chirps, clicks, voices).

Paying attention to attention: evidence for an attentional contribution to the size congruity effect.

PubMed

Risko, Evan F; Maloney, Erin A; Fugelsang, Jonathan A

2013-08-01

Understanding the mechanisms supporting our comprehension of magnitude information represents a key goal in cognitive psychology. A major phenomenon employed in the pursuit of this goal has been the physical size congruity effect-namely, the observation that comparing the relative numerical sizes of two numbers is influenced by their relative physical sizes. The standard account of the physical size congruity effect attributes it to the automatic influence of the comparison of irrelevant physical magnitudes on numerical judgments. Here we develop an alternative account of this effect on the basis of the operation of attention in the typical size congruity display and the temporal dynamics of number comparison. We also provide a test of a number of predictions derived from this alternative account by combining a physical size congruity manipulation with a manipulation designed to alter the operation of attention within the typical size congruity display (i.e., a manipulation of the relative onsets of the digits). This test provides evidence consistent with an attentional contribution to the size congruity effect. Implications for our understanding of magnitude and the interactions between attention and magnitude are discussed.

Automated database-guided expert-supervised orientation for immunophenotypic diagnosis and classification of acute leukemia

PubMed Central

Lhermitte, L; Mejstrikova, E; van der Sluijs-Gelling, A J; Grigore, G E; Sedek, L; Bras, A E; Gaipa, G; Sobral da Costa, E; Novakova, M; Sonneveld, E; Buracchi, C; de Sá Bacelar, T; te Marvelde, J G; Trinquand, A; Asnafi, V; Szczepanski, T; Matarraz, S; Lopez, A; Vidriales, B; Bulsa, J; Hrusak, O; Kalina, T; Lecrevisse, Q; Martin Ayuso, M; Brüggemann, M; Verde, J; Fernandez, P; Burgos, L; Paiva, B; Pedreira, C E; van Dongen, J J M; Orfao, A; van der Velden, V H J

2018-01-01

Precise classification of acute leukemia (AL) is crucial for adequate treatment. EuroFlow has previously designed an AL orientation tube (ALOT) to guide towards the relevant classification panel (T-cell acute lymphoblastic leukemia (T-ALL), B-cell precursor (BCP)-ALL and/or acute myeloid leukemia (AML)) and final diagnosis. Now we built a reference database with 656 typical AL samples (145 T-ALL, 377 BCP-ALL, 134 AML), processed and analyzed via standardized protocols. Using principal component analysis (PCA)-based plots and automated classification algorithms for direct comparison of single-cells from individual patients against the database, another 783 cases were subsequently evaluated. Depending on the database-guided results, patients were categorized as: (i) typical T, B or Myeloid without or; (ii) with a transitional component to another lineage; (iii) atypical; or (iv) mixed-lineage. Using this automated algorithm, in 781/783 cases (99.7%) the right panel was selected, and data comparable to the final WHO-diagnosis was already provided in >93% of cases (85% T-ALL, 97% BCP-ALL, 95% AML and 87% mixed-phenotype AL patients), even without data on the full-characterization panels. Our results show that database-guided analysis facilitates standardized interpretation of ALOT results and allows accurate selection of the relevant classification panels, hence providing a solid basis for designing future WHO AL classifications. PMID:29089646

Optimization of Thermoelectric Components for Automobile Waste Heat Recovery Systems

NASA Astrophysics Data System (ADS)

Kumar, Sumeet; Heister, Stephen D.; Xu, Xianfan; Salvador, James R.

2015-10-01

For a typical spark ignition engine approximately 40% of available thermal energy is lost as hot exhaust gas. To improve fuel economy, researchers are currently evaluating technology which exploits exhaust stream thermal power by use of thermoelectric generators (TEGs) that operate on the basis of the Seebeck effect. A 5% improvement in fuel economy, achieved by use of TEG output power, is a stated objective for light-duty trucks and personal automobiles. System modeling of thermoelectric (TE) components requires solution of coupled thermal and electric fluxes through the n and p-type semiconductor legs, given appropriate thermal boundary conditions at the junctions. Such applications have large thermal gradients along the semiconductor legs, and material properties are highly dependent on spatially varying temperature profiles. In this work, one-dimensional heat flux and temperature variations across thermoelectric legs were solved by using an iterative numerical approach to optimize both TE module and TEG designs. Design traits were investigated by assuming use of skutterudite as a thermoelectric material with potential for automotive applications in which exhaust gas and heat exchanger temperatures typically vary from 100°C to over 600°C. Dependence of leg efficiency, thermal fluxes and electric power generation on leg geometry, fill fractions, electric current, thermal boundary conditions, etc., were studied in detail. Optimum leg geometries were computed for a variety of automotive exhaust conditions.

Analyzing the Stability of Price Response Functions: Measuring the Influence of Different Parameters in a Monte Carlo Comparison

NASA Astrophysics Data System (ADS)

Brusch, Michael; Baier, Daniel

The usage and the estimation of price response function is very important for strategic marketing decisions. Typically price response functions with an empirical basis are used. However, such price response functions are subject to a lot of disturbing influence factors, e.g., the assumed profit maximum price and the assumed corresponding quantity of sales. In such cases, the question how stable the found price response function is was not answered sufficiently up to now. In this paper, the question will be pursued how much (and what kind of) errors in market research are pardonable for a stable price response function. For the comparisons, a factorial design with synthetically generated and disturbed data is used.

Propellant Mass Fraction Calculation Methodology for Launch Vehicles

NASA Technical Reports Server (NTRS)

Holt, James B.; Monk, Timothy S.

2009-01-01

Propellant Mass Fraction (pmf) calculation methods vary throughout the aerospace industry. While typically used as a means of comparison between competing launch vehicle designs, the actual pmf calculation method varies slightly from one entity to another. It is the purpose of this paper to present various methods used to calculate the pmf of a generic launch vehicle. This includes fundamental methods of pmf calculation which consider only the loaded propellant and the inert mass of the vehicle, more involved methods which consider the residuals and any other unusable propellant remaining in the vehicle, and other calculations which exclude large mass quantities such as the installed engine mass. Finally, a historic comparison is made between launch vehicles on the basis of the differing calculation methodologies.

A framework for designing and implementing community benefit standards.

PubMed

Longo, D R; Kruse, R L; Kiely, R G

1997-01-01

Increasingly, health care professionals and the public are asking questions about the role of the hospital in meeting community need including its not-for-profit tax status. This article reviews the community benefit literature, provides a framework for understanding how a hospital community benefit program was developed, and delineates through a structured case study the lessons learned from this experience. It provides the practitioner with a context in which other hospitals may replicate the program and gives researchers a substantive case study that may be used as the basis for the empirical testing of community benefit models. The authors also outline the many difficult issues faced by a typical community hospital as it attempted to examine and develop additional responses to community need.

Reliable Real-Time Solution of Parametrized Partial Differential Equations: Reduced-Basis Output Bound Methods. Appendix 2

NASA Technical Reports Server (NTRS)

Prudhomme, C.; Rovas, D. V.; Veroy, K.; Machiels, L.; Maday, Y.; Patera, A. T.; Turinici, G.; Zang, Thomas A., Jr. (Technical Monitor)

2002-01-01

We present a technique for the rapid and reliable prediction of linear-functional outputs of elliptic (and parabolic) partial differential equations with affine parameter dependence. The essential components are (i) (provably) rapidly convergent global reduced basis approximations, Galerkin projection onto a space W(sub N) spanned by solutions of the governing partial differential equation at N selected points in parameter space; (ii) a posteriori error estimation, relaxations of the error-residual equation that provide inexpensive yet sharp and rigorous bounds for the error in the outputs of interest; and (iii) off-line/on-line computational procedures, methods which decouple the generation and projection stages of the approximation process. The operation count for the on-line stage, in which, given a new parameter value, we calculate the output of interest and associated error bound, depends only on N (typically very small) and the parametric complexity of the problem; the method is thus ideally suited for the repeated and rapid evaluations required in the context of parameter estimation, design, optimization, and real-time control.

Bilateral phacoemulsification and intraocular lens implantation in a great horned owl.

PubMed

Carter, Renee T; Murphy, Christopher J; Stuhr, Charles M; Diehl, Kathryn A

2007-02-15

A great horned owl of estimated age < 1 year that was captured by wildlife rehabilitators was evaluated because of suspected cataracts. Nuclear and incomplete cortical cataracts were evident in both eyes. Ocular ultrasonography revealed no evidence of retinal detachment, and electroretinography revealed normal retinal function. For visual rehabilitation, cataract surgery was planned and intraocular lens design was determined on the basis of values obtained from the schematic eye, which is a mathematical model representing a normal eye for a species. Cataract surgery and intraocular lens placement were performed in both eyes. After surgery, refraction was within -0.75 diopters in the right eye and -0.25 diopters in the left eye. Visual rehabilitation was evident on the basis of improved tracking and feeding behavior, and the owl was eventually released into the wild. In raptors with substantial visual compromise, euthanasia or placement in a teaching facility is a typical outcome because release of such a bird is unacceptable. Successful intraocular lens implantation for visual rehabilitation and successful release into the wild are achievable.

Advanced Test Reactor Safety Basis Upgrade Lessons Learned Relative to Design Basis Verification and Safety Basis Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

G. L. Sharp; R. T. McCracken

The Advanced Test Reactor (ATR) is a pressurized light-water reactor with a design thermal power of 250 MW. The principal function of the ATR is to provide a high neutron flux for testing reactor fuels and other materials. The reactor also provides other irradiation services such as radioisotope production. The ATR and its support facilities are located at the Test Reactor Area of the Idaho National Engineering and Environmental Laboratory (INEEL). An audit conducted by the Department of Energy's Office of Independent Oversight and Performance Assurance (DOE OA) raised concerns that design conditions at the ATR were not adequately analyzedmore » in the safety analysis and that legacy design basis management practices had the potential to further impact safe operation of the facility.1 The concerns identified by the audit team, and issues raised during additional reviews performed by ATR safety analysts, were evaluated through the unreviewed safety question process resulting in shutdown of the ATR for more than three months while these concerns were resolved. Past management of the ATR safety basis, relative to facility design basis management and change control, led to concerns that discrepancies in the safety basis may have developed. Although not required by DOE orders or regulations, not performing design basis verification in conjunction with development of the 10 CFR 830 Subpart B upgraded safety basis allowed these potential weaknesses to be carried forward. Configuration management and a clear definition of the existing facility design basis have a direct relation to developing and maintaining a high quality safety basis which properly identifies and mitigates all hazards and postulated accident conditions. These relations and the impact of past safety basis management practices have been reviewed in order to identify lessons learned from the safety basis upgrade process and appropriate actions to resolve possible concerns with respect to the current ATR safety basis. The need for a design basis reconstitution program for the ATR has been identified along with the use of sound configuration management principles in order to support safe and efficient facility operation.« less

The vocabulary profile of Slovak children with primary language impairment compared to typically developing Slovak children measured by LITMUS-CLT.

PubMed

Kapalková, Svetlana; Slančová, Daniela

2017-01-01

This study compared a sample of children with primary language impairment (PLI) and typically developing age-matched children using the crosslinguistic lexical tasks (CLT-SK). We also compared the PLI children with typically developing language-matched younger children who were matched on the basis of receptive vocabulary. Overall, statistical testing showed that the vocabulary of the PLI children was significantly different from the vocabulary of the age-matched children, but not statistically different from the younger children who were matched on the basis of their receptive vocabulary size. Qualitative analysis of the correct answers revealed that the PLI children showed higher rigidity compared to the younger language-matched children who are able to use more synonyms or derivations across word class in naming tasks. Similarly, an examination of the children's naming errors indicated that the language-matched children exhibited more semantic errors, whereas PLI children showed more associative errors.

Implementation of a best management practice (BMP) system for a clay mining facility in Taiwan.

PubMed

Lin, Jen-Yang; Chen, Yen-Chang; Chen, Walter; Lee, Tsu-Chuan; Yu, Shaw L

2006-01-01

The present paper describes the planning and implementation of a best management practice (BMP) system for a clay mining facility in Northern Taiwan. It is a challenge to plan and design BMPs for mitigating the impact of clay mining operations due to the fact that clay mining drainage typically contains very high concentrations of suspended solids (SS), Fe-ions, and [H+] concentrations. In the present study, a field monitoring effort was conducted to collect data for runoff quality and quantity from a clay mining area in Northern Taiwan. A BMP system including holding ponds connected in series was designed and implemented and its pollutant removal performance was assessed. The assessment was based on mass balance computations and an analysis of the relationship between BMP design parameters such as pond depth, detention time, surface loading rate, etc. and the pollutant removal efficiency. Field sampling results showed that the surface-loading rate is exponential related to the removing rate. The results provide the basis for a more comprehensive and efficient BMP implementation plan for clay mining operations.

Hemodynamic guidelines for design and control of a turbodynamic pediatric ventricular assist device.

PubMed

Uber, Bronwyn E; Webber, Steven A; Morell, Victor O; Antaki, James F

2006-01-01

The design of mechanical circulatory support devices typically requires a priori knowledge of the hemodynamic requirements of their intended use. These requirements are difficult to determine because of limited clinical experience. This is especially true for the pediatric population, for whom there is a dearth of longitudinal data. This report aims to provide both engineers and physicians with benchmarks for determining the optimal flow requirements and settings for pediatric ventricular assist devices that are currently being developed. Criteria were developed on the basis of estimates derived from various sources. The potential patient population was estimated by using the prevalence of children on the heart transplant waiting list and those placed on extracorporeal membrane oxygenation. Cardiac outputs were determined for individual weights and body surface areas, using published values for healthy and sick pediatric patients. The recommended pump range was optimized to include the most patients, while considering the design constraints. This study identifies a significant population of patients who would benefit from a device providing 0.52 to 1.92 l/min.

Fluctuating pressures in pump diffuser and collector scrolls, part 1

NASA Technical Reports Server (NTRS)

Sloteman, Donald P.

1989-01-01

The cracking of scroll liners on the SSME High Pressure Fuel Turbo Pump (HPFTP) on hot gas engine test firings has prompted a study into the nature of pressure fluctuations in centrifugal pump states. The amplitudes of these fluctuations and where they originate in the pump stage are quantified. To accomplish this, a test program was conducted to map the pressure pulsation activity in a centrifugal pump stage. This stage is based on typical commercial (or generic) pump design practice and not the specialized design of the HPFTP. Measurements made in the various elements comprising the stage indicate that pulsation activity is dominated by synchronous related phenomena. Pulsation amplitudes measured in the scroll are low, on the order of 2 to 7 percent of the impeller exit tip speed velocity head. Significant non-sychronous pressure fluctuations occur at low flow, and while of interest to commercial pump designers, have little meaning to the HPFTP experience. Results obtained with the generic components do provide insights into possible pulsation related scroll failures on the HPFTP, and provide a basis for further study.

Study on the properties of infrared wavefront coding athermal system under several typical temperature gradient distributions

NASA Astrophysics Data System (ADS)

Cai, Huai-yu; Dong, Xiao-tong; Zhu, Meng; Huang, Zhan-hua

2018-01-01

Wavefront coding for athermal technique can effectively ensure the stability of the optical system imaging in large temperature range, as well as the advantages of compact structure and low cost. Using simulation method to analyze the properties such as PSF and MTF of wavefront coding athermal system under several typical temperature gradient distributions has directive function to characterize the working state of non-ideal temperature environment, and can effectively realize the system design indicators as well. In this paper, we utilize the interoperability of data between Solidworks and ZEMAX to simplify the traditional process of structure/thermal/optical integrated analysis. Besides, we design and build the optical model and corresponding mechanical model of the infrared imaging wavefront coding athermal system. The axial and radial temperature gradients of different degrees are applied to the whole system by using SolidWorks software, thus the changes of curvature, refractive index and the distance between the lenses are obtained. Then, we import the deformation model to ZEMAX for ray tracing, and obtain the changes of PSF and MTF in optical system. Finally, we discuss and evaluate the consistency of the PSF (MTF) of the wavefront coding athermal system and the image restorability, which provides the basis and reference for the optimal design of the wavefront coding athermal system. The results show that the adaptability of single material infrared wavefront coding athermal system to axial temperature gradient can reach the upper limit of temperature fluctuation of 60°C, which is much higher than that of radial temperature gradient.

Solution structure of CXCL5--a novel chemokine and adipokine implicated in inflammation and obesity.

PubMed

Sepuru, Krishna Mohan; Poluri, Krishna Mohan; Rajarathnam, Krishna

2014-01-01

The chemokine CXCL5 is selectively expressed in highly specialized cells such as epithelial type II cells in the lung and white adipose tissue macrophages in muscle, where it mediates diverse functions from combating microbial infections by regulating neutrophil trafficking to promoting obesity by inhibiting insulin signaling. Currently very little is known regarding the structural basis of how CXCL5 mediates its novel functions. Towards this missing knowledge, we have solved the solution structure of the CXCL5 dimer by NMR spectroscopy. CXCL5 is a member of a subset of seven CXCR2-activating chemokines (CAC) that are characterized by the highly conserved ELR motif in the N-terminal tail. The structure shows that CXCL5 adopts the typical chemokine fold, but also reveals several distinct differences in the 30 s loop and N-terminal residues; not surprisingly, crosstalk between N-terminal and 30 s loop residues have been implicated as a major determinant of receptor activity. CAC function also involves binding to highly sulfated glycosaminoglycans (GAG), and the CXCL5 structure reveals a distinct distribution of positively charged residues, suggesting that differences in GAG interactions also influence function. The availability of the structure should now facilitate the design of experiments to better understand the molecular basis of various CXCL5 functions, and also serve as a template for the design of inhibitors for use in a clinical setting.

System-Level Heat Transfer Analysis, Thermal- Mechanical Cyclic Stress Analysis, and Environmental Fatigue Modeling of a Two-Loop Pressurized Water Reactor. A Preliminary Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohanty, Subhasish; Soppet, William; Majumdar, Saurin

This report provides an update on an assessment of environmentally assisted fatigue for light water reactor components under extended service conditions. This report is a deliverable in April 2015 under the work package for environmentally assisted fatigue under DOE's Light Water Reactor Sustainability program. In this report, updates are discussed related to a system level preliminary finite element model of a two-loop pressurized water reactor (PWR). Based on this model, system-level heat transfer analysis and subsequent thermal-mechanical stress analysis were performed for typical design-basis thermal-mechanical fatigue cycles. The in-air fatigue lives of components, such as the hot and cold legs,more » were estimated on the basis of stress analysis results, ASME in-air fatigue life estimation criteria, and fatigue design curves. Furthermore, environmental correction factors and associated PWR environment fatigue lives for the hot and cold legs were estimated by using estimated stress and strain histories and the approach described in NUREG-6909. The discussed models and results are very preliminary. Further advancement of the discussed model is required for more accurate life prediction of reactor components. This report only presents the work related to finite element modelling activities. However, in between multiple tensile and fatigue tests were conducted. The related experimental results will be presented in the year-end report.« less

A novel system architecture for the national integration of electronic health records: a semi-centralized approach.

PubMed

AlJarullah, Asma; El-Masri, Samir

2013-08-01

The goal of a national electronic health records integration system is to aggregate electronic health records concerning a particular patient at different healthcare providers' systems to provide a complete medical history of the patient. It holds the promise to address the two most crucial challenges to the healthcare systems: improving healthcare quality and controlling costs. Typical approaches for the national integration of electronic health records are a centralized architecture and a distributed architecture. This paper proposes a new approach for the national integration of electronic health records, the semi-centralized approach, an intermediate solution between the centralized architecture and the distributed architecture that has the benefits of both approaches. The semi-centralized approach is provided with a clearly defined architecture. The main data elements needed by the system are defined and the main system modules that are necessary to achieve an effective and efficient functionality of the system are designed. Best practices and essential requirements are central to the evolution of the proposed architecture. The proposed architecture will provide the basis for designing the simplest and the most effective systems to integrate electronic health records on a nation-wide basis that maintain integrity and consistency across locations, time and systems, and that meet the challenges of interoperability, security, privacy, maintainability, mobility, availability, scalability, and load balancing.

How Heterogeneity Affects the Design of Hadoop MapReduce Schedulers: A State-of-the-Art Survey and Challenges.

PubMed

Pandey, Vaibhav; Saini, Poonam

2018-06-01

MapReduce (MR) computing paradigm and its open source implementation Hadoop have become a de facto standard to process big data in a distributed environment. Initially, the Hadoop system was homogeneous in three significant aspects, namely, user, workload, and cluster (hardware). However, with growing variety of MR jobs and inclusion of different configurations of nodes in the existing cluster, heterogeneity has become an essential part of Hadoop systems. The heterogeneity factors adversely affect the performance of a Hadoop scheduler and limit the overall throughput of the system. To overcome this problem, various heterogeneous Hadoop schedulers have been proposed in the literature. Existing survey works in this area mostly cover homogeneous schedulers and classify them on the basis of quality of service parameters they optimize. Hence, there is a need to study the heterogeneous Hadoop schedulers on the basis of various heterogeneity factors considered by them. In this survey article, we first discuss different heterogeneity factors that typically exist in a Hadoop system and then explore various challenges that arise while designing the schedulers in the presence of such heterogeneity. Afterward, we present the comparative study of heterogeneous scheduling algorithms available in the literature and classify them by the previously said heterogeneity factors. Lastly, we investigate different methods and environment used for evaluation of discussed Hadoop schedulers.

Molecular Basis for Failure of “Atypical” C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester*

PubMed Central

Geczy, Tamas; Peach, Megan L.; El Kazzouli, Saïd; Sigano, Dina M.; Kang, Ji-Hye; Valle, Christopher J.; Selezneva, Julia; Woo, Wonhee; Kedei, Noemi; Lewin, Nancy E.; Garfield, Susan H.; Lim, Langston; Mannan, Poonam; Marquez, Victor E.; Blumberg, Peter M.

2012-01-01

C1 domains, the recognition motif of the second messenger diacylglycerol and of the phorbol esters, are classified as typical (ligand-responsive) or atypical (not ligand-responsive). The C1 domain of Vav1, a guanine nucleotide exchange factor, plays a critical role in regulation of Vav activity through stabilization of the Dbl homology domain, which is responsible for exchange activity of Vav. Although the C1 domain of Vav1 is classified as atypical, it retains a binding pocket geometry homologous to that of the typical C1 domains of PKCs. This study clarifies the basis for its failure to bind ligands. Substituting Vav1-specific residues into the C1b domain of PKCδ, we identified five crucial residues (Glu9, Glu10, Thr11, Thr24, and Tyr26) along the rim of the binding cleft that weaken binding potency in a cumulative fashion. Reciprocally, replacing these incompatible residues in the Vav1 C1 domain with the corresponding residues from PKCδ C1b (δC1b) conferred high potency for phorbol ester binding. Computer modeling predicts that these unique residues in Vav1 increase the hydrophilicity of the rim of the binding pocket, impairing membrane association and thereby preventing formation of the ternary C1-ligand-membrane binding complex. The initial design of diacylglycerol-lactones to exploit these Vav1 unique residues showed enhanced selectivity for C1 domains incorporating these residues, suggesting a strategy for the development of ligands targeting Vav1. PMID:22351766

Detector Noise Characterization and Performance of MODIS Thermal Emissive Bands

NASA Technical Reports Server (NTRS)

Xiong, X.; Wu, A.; Chen, N.; Chiang, K.; Xiong, S.; Wenny, B.; Barnes, W. L.

2007-01-01

MODIS has 16 thermal emissive bands, a total of 160 individual detectors (10 for each spectral bands), located on the two cold focal plane assemblies (CFPA). MODIS TEB detectors were fully characterized pre-launch in a thermal vacuum (TV) environment using a NIST traceable blackbody calibration source (BCS) with temperatures ranging from 170 to 340K. On-orbit the TEB detectors are calibrated using an on-board blackbody (BB) on a scan-by-scan basis. For nominal on-orbit operation, the on-board BB temperature is typically controlled at 285K for Aqua MODIS and 290K for Terra MODIS. For the MODIS TEB calibration, each detector's noise equivalent temperature difference (NEdT) is often used to assess its performance and this parameter is a major contributor to the calibration uncertainty. Because of its impact on sensor calibration and data product quality, each MODIS TEB detector's NEdT is monitored on a daily basis at a fixed BB temperature and completely characterized on a regular basis at a number of BB temperatures. In this paper, we describe MODIS on-orbit TEB NEdT characterization activities, approaches, and results. We compare both pre-launch and on-orbit performance with sensor design specification and examine detector noise characterization impact on the calibration uncertainty. To date, 135 TEB detectors (out of a total of 160 detectors) in Terra MODIS (launched in December 1999) and 158 in Aqua MODIS (launched in May 2002) continue to perform with their NEdT below (or better than) their design specifications. A complete summary of all TEB noisy detectors, identified both pre-launch and on-orbit, is provided.

Renormalization Analysis of a Composite Ultrasonic Transducer with a Fractal Architecture

NASA Astrophysics Data System (ADS)

Algehyne, Ebrahem A.; Mulholland, Anthony J.

To ensure the safe operation of many safety critical structures such as nuclear plants, aircraft and oil pipelines, non-destructive imaging is employed using piezoelectric ultrasonic transducers. These sensors typically operate at a single frequency due to the restrictions imposed on their resonant behavior by the use of a single length scale in the design. To allow these transducers to transmit and receive more complex signals it would seem logical to use a range of length scales in the design so that a wide range of resonating frequencies will result. In this paper, we derive a mathematical model to predict the dynamics of an ultrasound transducer that achieves this range of length scales by adopting a fractal architecture. In fact, the device is modeled as a graph where the nodes represent segments of the piezoelectric and polymer materials. The electrical and mechanical fields that are contained within this graph are then expressed in terms of a finite element basis. The structure of the resulting discretized equations yields to a renormalization methodology which is used to derive expressions for the non-dimensionalized electrical impedance and the transmission and reception sensitivities. A comparison with a standard design shows some benefits of these fractal designs.

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

Analytical fuel property effects, small combustors, phase 1

NASA Technical Reports Server (NTRS)

Cohen, J. D.

1983-01-01

The effects of nonstandard aviation fuels on a typical small gas turbine combustor was analyzed. The T700/CT7 engine family was chosen as being representative of the class of aircraft power plants desired. Fuel properties, as specified by NASA, are characterized by low hydrogen content and high aromatics levels. Higher than normal smoke output and flame radiation intensity for the current T700 combustor which serves as a baseline were anticipated. It is, therefore, predicted that out of specification smoke visibility and higher than normal shell temperatures will exist when using NASA ERBS fuels with a consequence of severe reduction in cyclic life. Three new designs are proposed to compensate for the deficiencies expected with the existing design. They have emerged as the best of the eight originally proposed redesigns or combinations thereof. After the five choices that were originally made by NASA on the basis of competing performance factors, General Electric narrowed the field to the three proposed.

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

NASA Astrophysics Data System (ADS)

Kugel, Susann; Baunach, Martin; Baer, Philipp; Ishida-Ito, Mie; Sundaram, Srividhya; Xu, Zhongli; Groll, Michael; Hertweck, Christian

2017-06-01

Terpenoid natural products comprise a wide range of molecular architectures that typically result from C-C bond formations catalysed by classical type I/II terpene cyclases. However, the molecular diversity of biologically active terpenoids is substantially increased by fully unrelated, non-canonical terpenoid cyclases. Their evolutionary origin has remained enigmatic. Here we report the in vitro reconstitution of an unusual flavin-dependent bacterial indoloterpenoid cyclase, XiaF, together with a designated flavoenzyme-reductase (XiaP) that mediates a key step in xiamycin biosynthesis. The crystal structure of XiaF with bound FADH2 (at 2.4 Å resolution) and phylogenetic analyses reveal that XiaF is, surprisingly, most closely related to xenobiotic-degrading enzymes. Biotransformation assays show that XiaF is a designated indole hydroxylase that can be used for the production of indigo and indirubin. We unveil a cryptic hydroxylation step that sets the basis for terpenoid cyclization and suggest that the cyclase has evolved from xenobiotics detoxification enzymes.

Anthropometry for WorldSID, a World-Harmonized Midsize Male Side Impact Crash Dummy

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. Moss; Z. Wang; M. Salloum

2000-06-19

The WorldSID project is a global effort to design a new generation side impact crash test dummy under the direction of the International Organization for Standardization (ISO). The first WorldSID crash dummy will represent a world-harmonized mid-size adult male. This paper discusses the research and rationale undertaken to define the anthropometry of a world standard midsize male in the typical automotive seated posture. Various anthropometry databases are compared region by region and in terms of the key dimensions needed for crash dummy design. The Anthropometry for Motor Vehicle Occupants (AMVO) dataset, as established by the University of Michigan Transportation Researchmore » Institute (UMTRI), is selected as the basis for the WorldSID mid-size male, updated to include revisions to the pelvis bone location. The proposed mass of the dummy is 77.3kg with full arms. The rationale for the selected mass is discussed. The joint location and surface landmark database is appended to this paper.« less

Decoy-state quantum key distribution with biased basis choice

PubMed Central

Wei, Zhengchao; Wang, Weilong; Zhang, Zhen; Gao, Ming; Ma, Zhi; Ma, Xiongfeng

2013-01-01

We propose a quantum key distribution scheme that combines a biased basis choice with the decoy-state method. In this scheme, Alice sends all signal states in the Z basis and decoy states in the X and Z basis with certain probabilities, and Bob measures received pulses with optimal basis choice. This scheme simplifies the system and reduces the random number consumption. From the simulation result taking into account of statistical fluctuations, we find that in a typical experimental setup, the proposed scheme can increase the key rate by at least 45% comparing to the standard decoy-state scheme. In the postprocessing, we also apply a rigorous method to upper bound the phase error rate of the single-photon components of signal states. PMID:23948999

Decoy-state quantum key distribution with biased basis choice.

PubMed

Wei, Zhengchao; Wang, Weilong; Zhang, Zhen; Gao, Ming; Ma, Zhi; Ma, Xiongfeng

2013-01-01

We propose a quantum key distribution scheme that combines a biased basis choice with the decoy-state method. In this scheme, Alice sends all signal states in the Z basis and decoy states in the X and Z basis with certain probabilities, and Bob measures received pulses with optimal basis choice. This scheme simplifies the system and reduces the random number consumption. From the simulation result taking into account of statistical fluctuations, we find that in a typical experimental setup, the proposed scheme can increase the key rate by at least 45% comparing to the standard decoy-state scheme. In the postprocessing, we also apply a rigorous method to upper bound the phase error rate of the single-photon components of signal states.

EMISSIONS OF ORGANIC AIR TOXICS FROM OPEN ...

EPA Pesticide Factsheets

A detailed literature search was performed to collect and collate available data reporting emissions of toxic organic substances into the air from open burning sources. Availability of data varied according to the source and the class of air toxics of interest. Volatile organic compound (VOC) and polycyclic aromatic hydrocarbon (PAH) data were available for many of the sources. Data on semivolatile organic compounds (SVOCs) that are not PAHs were available for several sources. Carbonyl and polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofuran (PCDD/F) data were available for only a few sources. There were several sources for which no emissions data were available at all. Several observations were made including: 1) Biomass open burning sources typically emitted less VOCs than open burning sources with anthropogenic fuels on a mass emitted per mass burned basis, particularly those where polymers were concerned; 2) Biomass open burning sources typically emitted less SVOCs and PAHs than anthropogenic sources on a mass emitted per mass burned basis. Burning pools of crude oil and diesel fuel produced significant amounts of PAHs relative to other types of open burning. PAH emissions were highest when combustion of polymers was taking place; and 3) Based on very limited data, biomass open burning sources typically produced higher levels of carbonyls than anthropogenic sources on a mass emitted per mass burned basis, probably due to oxygenated structures r

The Badger Company conceptual design of a 50 MGD desalination plant. Special report No. 10

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1965-08-01

The objective of this study is to produce a design which advances the technology of seawater conversion and to present the results in a form which can be used by any qualified individual or firm as the basis for an architectural-engineering design. Ground rules furnished by OSW specified that only the desalination section of a dual-purpose power-water plant be considered and that it be designed for a 30-year life. Process and structural design ideas are to be presented in terms of the complete plant concept. The complex is to be located on a typical California coastal site with capital andmore » operating costs based on December, 1964, values. The Badger study considers the Multi-Stage Flash (MSF) process, achieving a minimum overall pressure drop by an uninterrupted flow path of brine and product water through the evaporator flashing area. A performance ratio of 20 pounds of product water per pound of steam yields a calculated water cost of $0.323 per thousand gallons. The specified 30-year write-off at low interest rates allows comparatively high capital expenditures favoring titanium tubing for brine service which contributes to low maintenance and operating costs. (GRA)« less

Experimental design and efficient parameter estimation in preclinical pharmacokinetic studies.

PubMed

Ette, E I; Howie, C A; Kelman, A W; Whiting, B

1995-05-01

Monte Carlo simulation technique used to evaluate the effect of the arrangement of concentrations on the efficiency of estimation of population pharmacokinetic parameters in the preclinical setting is described. Although the simulations were restricted to the one compartment model with intravenous bolus input, they provide the basis of discussing some structural aspects involved in designing a destructive ("quantic") preclinical population pharmacokinetic study with a fixed sample size as is usually the case in such studies. The efficiency of parameter estimation obtained with sampling strategies based on the three and four time point designs were evaluated in terms of the percent prediction error, design number, individual and joint confidence intervals coverage for parameter estimates approaches, and correlation analysis. The data sets contained random terms for both inter- and residual intra-animal variability. The results showed that the typical population parameter estimates for clearance and volume were efficiently (accurately and precisely) estimated for both designs, while interanimal variability (the only random effect parameter that could be estimated) was inefficiently (inaccurately and imprecisely) estimated with most sampling schedules of the two designs. The exact location of the third and fourth time point for the three and four time point designs, respectively, was not critical to the efficiency of overall estimation of all population parameters of the model. However, some individual population pharmacokinetic parameters were sensitive to the location of these times.

A generalized algorithm to design finite field normal basis multipliers

NASA Technical Reports Server (NTRS)

Wang, C. C.

1986-01-01

Finite field arithmetic logic is central in the implementation of some error-correcting coders and some cryptographic devices. There is a need for good multiplication algorithms which can be easily realized. Massey and Omura recently developed a new multiplication algorithm for finite fields based on a normal basis representation. Using the normal basis representation, the design of the finite field multiplier is simple and regular. The fundamental design of the Massey-Omura multiplier is based on a design of a product function. In this article, a generalized algorithm to locate a normal basis in a field is first presented. Using this normal basis, an algorithm to construct the product function is then developed. This design does not depend on particular characteristics of the generator polynomial of the field.

Justification of Structural and Technological Solutions on Junction Perfecting on Permyakova and Shirotnaya Streets Intersection in Tyumen

NASA Astrophysics Data System (ADS)

Sannikov, S. P.; Timohovetz, V. D.; Kuzuek, A. Y.

2017-11-01

This article presents the justification of structurally-technological decisions on a junction perfecting on the intersection of Permyakova and Shirotnaya Streets in Tyumen. The authors made a comparative analysis of typical road junctions. Based on the comparison, the engineering decisions were made for an individual type of transport junctions. Several options of individual design were proposed and analyzed and three most suitable types for the road junctions were offered. On the basis of a multilateral studying and evaluation of the developed transport the article further proposed a transport junction with change-side traffic. The use of this type of intersection will increase the road junction capacity, reduce the number of accidents due to conflicting flows reduction which, in its turn, will increase the speed of cars.

Resonant tunneling structures based on epitaxial graphene on SiC

NASA Astrophysics Data System (ADS)

Nguyen, V. Hung; Bournel, A.; Dollfus, P.

2011-12-01

Recently some experiments have suggested that graphene epitaxially grown on SiC can exhibit an energy bandgap of 260 meV, which enhances the potential of this material for electronic applications. On this basis, we propose to use spatial doping to generate graphene-on-SiC double-barrier structures. The non-equilibrium Green's function technique for solving the massive Dirac model is applied to highlight typical transport phenomena such as the electron confinement and the resonant tunneling effects. The I-V characteristics of graphene resonant tunneling diodes were then investigated and the effect of different device parameters was discussed. It is finally shown that this kind of double-barrier junction provides an efficient way to confine the charge carriers in graphene and to design graphene resonant tunneling structures.

Dataflow computing approach in high-speed digital simulation

NASA Technical Reports Server (NTRS)

Ercegovac, M. D.; Karplus, W. J.

1984-01-01

New computational tools and methodologies for the digital simulation of continuous systems were explored. Programmability, and cost effective performance in multiprocessor organizations for real time simulation was investigated. Approach is based on functional style languages and data flow computing principles, which allow for the natural representation of parallelism in algorithms and provides a suitable basis for the design of cost effective high performance distributed systems. The objectives of this research are to: (1) perform comparative evaluation of several existing data flow languages and develop an experimental data flow language suitable for real time simulation using multiprocessor systems; (2) investigate the main issues that arise in the architecture and organization of data flow multiprocessors for real time simulation; and (3) develop and apply performance evaluation models in typical applications.

From Action to Interaction: Exploring the Contribution of Body Motion Cues to Social Understanding in Typical Development and in Autism Spectrum Disorders

ERIC Educational Resources Information Center

Centelles, Laurie; Assaiante, Christine; Etchegoyhen, Katallin; Bouvard, Manuel; Schmitz, Christina

2013-01-01

Two studies investigated whether typically developing children (TD) and children with autism spectrum disorders (ASD) were able to decide whether two characters were communicating or not on the basis of point-light displays. Point-lights portrayed actors engaged or not in a social interaction. In study 1, TD children (4-10 years old; n = 36)…

Dimensional analysis using toric ideals: primitive invariants.

PubMed

Atherton, Mark A; Bates, Ronald A; Wynn, Henry P

2014-01-01

Classical dimensional analysis in its original form starts by expressing the units for derived quantities, such as force, in terms of power products of basic units [Formula: see text] etc. This suggests the use of toric ideal theory from algebraic geometry. Within this the Graver basis provides a unique primitive basis in a well-defined sense, which typically has more terms than the standard Buckingham approach. Some textbook examples are revisited and the full set of primitive invariants found. First, a worked example based on convection is introduced to recall the Buckingham method, but using computer algebra to obtain an integer [Formula: see text] matrix from the initial integer [Formula: see text] matrix holding the exponents for the derived quantities. The [Formula: see text] matrix defines the dimensionless variables. But, rather than this integer linear algebra approach it is shown how, by staying with the power product representation, the full set of invariants (dimensionless groups) is obtained directly from the toric ideal defined by [Formula: see text]. One candidate for the set of invariants is a simple basis of the toric ideal. This, although larger than the rank of [Formula: see text], is typically not unique. However, the alternative Graver basis is unique and defines a maximal set of invariants, which are primitive in a simple sense. In addition to the running example four examples are taken from: a windmill, convection, electrodynamics and the hydrogen atom. The method reveals some named invariants. A selection of computer algebra packages is used to show the considerable ease with which both a simple basis and a Graver basis can be found.

Degrees of connectivity: Systems model for upstream risk assessment and mitigation.

PubMed

Gambatese, John; AlOmari, Kasim

2016-08-01

There is growing recognition that in order to further improve safety performance, attention needs to be given beyond the immediate working conditions and worker actions. A systems approach to construction safety enables considering: multiple project elements simultaneously; connections between different elements; and all system elements affected by safety risk. This paper describes recent and current research to conceptualize a typical building project in terms of connections between workers, activities, and design elements, and to verify and analyze impacts of the design and worker interactions on worker safety. Prior research provides the basis for a network tying the design elements, construction activities, and work crews on a typical building project together along with the extent of interaction between each of the system elements in terms of safety. In conjunction with this systems approach, the researchers propose a concept for viewing and managing construction safety through four different types of connections, or "degrees of connectivity," between the different workers, activities, and design elements in the system. The degrees of connectivity are defined as: interacting with the design element during its construction (DoC #1); interacting with the design element in its final form to attach another component to it (DoC #2) or by working in the vicinity of it (DoC #3); and indirectly interacting with the design element through another worker (DoC #4). To support and verify the presence of the concept in practice, the researchers conducted a survey of construction personnel. The survey results confirm that the four different degrees of connectivity are present and felt during construction operations, and indicate that attention should be given to all design elements, activities, and workers to which a worker is "connected". According to the survey respondents, DoC's #1 and #2 are recognized as the most widely present on construction sites. Eighty percent of the respondents believe that the design element has a moderate or greater impact on worker safety while it is being constructed. These initial research steps provide the starting point for continuing study that aims to develop and demonstrate the degrees of connectivity concept linking workers and design elements, with the goal of understanding how to design a project and work operations in order to improve safety during construction. Copyright © 2015 Elsevier Ltd. All rights reserved.

10 CFR 50.49 - Environmental qualification of electric equipment important to safety for nuclear power plants.

Code of Federal Regulations, 2014 CFR

2014-01-01

... following design basis events to ensure— (A) The integrity of the reactor coolant pressure boundary; (B) The...) Design basis events are defined as conditions of normal operation, including anticipated operational occurrences, design basis accidents, external events, and natural phenomena for which the plant must be...

10 CFR 50.49 - Environmental qualification of electric equipment important to safety for nuclear power plants.

Code of Federal Regulations, 2013 CFR

2013-01-01

... following design basis events to ensure— (A) The integrity of the reactor coolant pressure boundary; (B) The...) Design basis events are defined as conditions of normal operation, including anticipated operational occurrences, design basis accidents, external events, and natural phenomena for which the plant must be...

10 CFR 50.49 - Environmental qualification of electric equipment important to safety for nuclear power plants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... following design basis events to ensure— (A) The integrity of the reactor coolant pressure boundary; (B) The...) Design basis events are defined as conditions of normal operation, including anticipated operational occurrences, design basis accidents, external events, and natural phenomena for which the plant must be...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Satisfactory service as a design basis. 177.310 Section... (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull, deckhouse, and frames of the vessel differ from those...

Exogenous lipoid pneumonia – a case report of a fire-eater

PubMed Central

Pielaszkiewicz-Wydra, Magdalena; Homola-Piekarska, Bożena; Szcześniak, Ewa; Ciołek-Zdun, Monika; Fall, Andrzej

2012-01-01

Summary Background: Exogenous lipoid pneumonia is an uncommon condition caused by inhalation or aspiration of a fatty substance. It usually presents as chronic respiratory illness mimicking interstitial lung diseases. Acute exogenous lipoid pneumonia is uncommon and typically is caused by an episode of aspiration of a large quantity of a petroleum-based product. Radiological findings vary and may imitate many other diseases. Case Report: We present a rare case of acute exogenous lipoid pneumonia in a fire-eater who aspirated liquid paraffin during his flame-blowing show (fire-eater’s lung). He was admitted to the hospital with productive cough, fever, hemoptysis, chest pain and dyspnea. Diagnosis was made on the basis of history of exposure to fatty substance, characteristic findings in CT examination and presence of lipid-laden macrophages in bronchoalveolar lavage fluid. Conclusions: Acute exogenous lipoid pneumonia is a very rare disease that typically occurs in fire-eaters and is called a fire-eater’s lung. The diagnosis is made on the basis of typical history and radiological, as well as histopathological findings. PMID:23269939

In Vivo Measurement of Surface Pressures and Retraction Distances Applied on Abdominal Organs During Surgery.

PubMed

Shah, Dignesh; Alderson, Andrew; Corden, James; Satyadas, Thomas; Augustine, Titus

2018-02-01

This study undertook the in vivo measurement of surface pressures applied by the fingers of the surgeon during typical representative retraction movements of key human abdominal organs during both open and hand-assisted laparoscopic surgery. Surface pressures were measured using a flexible thin-film pressure sensor for 35 typical liver retractions to access the gall bladder, 36 bowel retractions, 9 kidney retractions, 8 stomach retractions, and 5 spleen retractions across 12 patients undergoing open and laparoscopic abdominal surgery. The maximum and root mean square surface pressures were calculated for each organ retraction. The maximum surface pressures applied to these key abdominal organs are in the range 1 to 41 kPa, and the average maximum surface pressure for all organs and procedures was 14 ± 3 kPa. Surface pressure relaxation during the retraction hold period was observed. Generally, the surface pressures are higher, and the rate of surface pressure relaxation is lower, in the more confined hand-assisted laparoscopic procedures than in open surgery. Combined video footage and pressure sensor data for retraction of the liver in open surgery enabled correlation of organ retraction distance with surface pressure application. The data provide a platform to design strategies for the prevention of retraction injuries. They also form a basis for the design of next-generation organ retraction and space creation surgical devices with embedded sensors that can further quantify intraoperative retraction forces to reduce injury or trauma to organs and surrounding tissues.

Discounting the future: influence of the economic model.

PubMed Central

West, R R

1996-01-01

OBJECTIVE: To consider the effect of the economic discount rate on health care policy and the rationale for discounting the collective future of society generally. DESIGN: A review of the concept of discounting the future vis à vis the present from the points of view of individuals (who pass on) and of societies (that continue) and reconsideration of the application of discounting to typical public health scenarios. SETTING: A public health service, within a basically stable society, which can reasonably anticipate a nearly certain future. RESULTS: Discounting necessarily overvalues the "here and now" compared with the future. While applications of discount rates, typical of those employed in health economic studies in recent years, may seem rational in health care programmes directed at middle aged employed people, they do not for the young and the elderly, important recipients of health care. The consequences of discounting do not accord with the aims and objectives of public health. CONCLUSIONS: The "time preferences" of transient individuals within a stable society do not provide a rational basis for time preference of a stable society collectively. Discounting inevitably encourages "short termism" and hence biases public policy decision making. The neoclassical theory that gave rise to the concept of discounting requires revision. PMID:8935452

Analysis on the impact of FBG reflectance spectrum with different optical fiber connection in vacuum thermal environment

NASA Astrophysics Data System (ADS)

Zhang, Jingchuan; Zhang, Wen; Lv, Jianfeng; Liang, Shuo; Wang, Lei; Li, Xiyuan

2018-01-01

To satisfy the application of fiber grating sensor technology in high vacuum thermal environment, FBG on sleeve compactly single model fiber with two typical different kind of connection such as fiber splicing and optical fiber connector are researched. Influence of the different connection to the characteristic of FBG reflectance spectrum in high vacuum thermal environment is analyzed and verified. First, experimental program of influence on FBG reflection spectrum characteristics is designed. Then, a hardware-in-the-loop detection platform is set up. Finally, the influence of temperature and vacuum on the reflection peak power of FBG with two typical different connections under high vacuum thermal environment is studied and verified. Experimental results indicate that: when vacuum varied from normal pressure to 10-4Pa level and then return to normal pressure, temperature of two different single-mode optical fiber connection dropped to -196 °C from room temperature and then returned to room temperature, after 224 hours, the peak power of the FBG reflectance spectrum did not change. It provided the experimental basis for the application of optical fiber sensing technology in high vacuum (pressure about 10-4Pa level) and thermal environment (-196 °C temperature cycle).

Early Onset Malignancies - Genomic Study of Cancer Disparities

Cancer.gov

The Early Onset Malignancies Initiative studies the genomic basis of six cancers that develop at an earlier age, occur in higher rates, and are typically more aggressive in certain minority populations.

10 CFR 72.94 - Design basis external man-induced events.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Design basis external man-induced events. 72.94 Section 72.94 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Siting Evaluation Factors § 72.94 Design basi...

78 FR 60321 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... sample selection. A steam generator tube rupture (SGTR) event is one of the design basis accidents that... in the design basis accident analysis. The proposed change will not cause the consequences of a SGTR... changes to the plant design basis or postulated accidents resulting from potential tube degradation. The...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Satisfactory service as a design basis. 177.310 Section 177.310 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull,...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Satisfactory service as a design basis. 177.310 Section 177.310 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull,...

46 CFR 177.310 - Satisfactory service as a design basis.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Satisfactory service as a design basis. 177.310 Section 177.310 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.310 Satisfactory service as a design basis. When scantlings for the hull,...

10 CFR 72.94 - Design basis external man-induced events.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

10 CFR 72.94 - Design basis external man-induced events.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

10 CFR 72.94 - Design basis external man-induced events.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

10 CFR 72.94 - Design basis external man-induced events.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

10 CFR 72.92 - Design basis external natural events.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... potential effects on the safe operation of the ISFSI or MRS. The important natural phenomena that affect the...

10 CFR 72.92 - Design basis external natural events.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... potential effects on the safe operation of the ISFSI or MRS. The important natural phenomena that affect the...

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strushkevich, Natallia; Usanov, Sergey A.; Park, Hee-Won

2010-09-22

The obligatory step in sterol biosynthesis in eukaryotes is demethylation of sterol precursors at the C14-position, which is catalyzed by CYP51 (sterol 14-alpha demethylase) in three sequential reactions. In mammals, the final product of the pathway is cholesterol, while important intermediates, meiosis-activating sterols, are produced by CYP51. Three crystal structures of human CYP51, ligand-free and complexed with antifungal drugs ketoconazole and econazole, were determined, allowing analysis of the molecular basis for functional conservation within the CYP51 family. Azole binding occurs mostly through hydrophobic interactions with conservative residues of the active site. The substantial conformational changes in the B{prime} helix andmore » F-G loop regions are induced upon ligand binding, consistent with the membrane nature of the protein and its substrate. The access channel is typical for mammalian sterol-metabolizing P450 enzymes, but is different from that observed in Mycobacterium tuberculosis CYP51. Comparison of the azole-bound structures provides insight into the relative binding affinities of human and bacterial P450 enzymes to ketoconazole and fluconazole, which can be useful for the rational design of antifungal compounds and specific modulators of human CYP51.« less

A stochastic approach for automatic generation of urban drainage systems.

PubMed

Möderl, M; Butler, D; Rauch, W

2009-01-01

Typically, performance evaluation of new developed methodologies is based on one or more case studies. The investigation of multiple real world case studies is tedious and time consuming. Moreover extrapolating conclusions from individual investigations to a general basis is arguable and sometimes even wrong. In this article a stochastic approach is presented to evaluate new developed methodologies on a broader basis. For the approach the Matlab-tool "Case Study Generator" is developed which generates a variety of different virtual urban drainage systems automatically using boundary conditions e.g. length of urban drainage system, slope of catchment surface, etc. as input. The layout of the sewer system is based on an adapted Galton-Watson branching process. The sub catchments are allocated considering a digital terrain model. Sewer system components are designed according to standard values. In total, 10,000 different virtual case studies of urban drainage system are generated and simulated. Consequently, simulation results are evaluated using a performance indicator for surface flooding. Comparison between results of the virtual and two real world case studies indicates the promise of the method. The novelty of the approach is that it is possible to get more general conclusions in contrast to traditional evaluations with few case studies.

Reexamining the minimum viable population concept for long-lived species.

PubMed

Shoemaker, Kevin T; Breisch, Alvin R; Jaycox, Jesse W; Gibbs, James P

2013-06-01

For decades conservation biologists have proposed general rules of thumb for minimum viable population size (MVP); typically, they range from hundreds to thousands of individuals. These rules have shifted conservation resources away from small and fragmented populations. We examined whether iteroparous, long-lived species might constitute an exception to general MVP guidelines. On the basis of results from a 10-year capture-recapture study in eastern New York (U.S.A.), we developed a comprehensive demographic model for the globally threatened bog turtle (Glyptemys muhlenbergii), which is designated as endangered by the IUCN in 2011. We assessed population viability across a wide range of initial abundances and carrying capacities. Not accounting for inbreeding, our results suggest that bog turtle colonies with as few as 15 breeding females have >90% probability of persisting for >100 years, provided vital rates and environmental variance remain at currently estimated levels. On the basis of our results, we suggest that MVP thresholds may be 1-2 orders of magnitude too high for many long-lived organisms. Consequently, protection of small and fragmented populations may constitute a viable conservation option for such species, especially in a regional or metapopulation context. © 2013 Society for Conservation Biology.

Accounting for intended use application in characterizing the contributions of cyclopentasiloxane (D5) to aquatic loadings following personal care product use: antiperspirants, skin care products and hair care products.

PubMed

Montemayor, Beta P; Price, Bradford B; van Egmond, Roger A

2013-10-01

Decamethylcyclopentasiloxane, commonly known as D5 (cyclopentasiloxane) has a wide application of use across a multitude of personal care product categories. The relative volatility of D5 is one of the key properties attributed to this substance that provide for the derived performance benefits from the use of this raw material in personal care formulations. On this basis, rapid evaporative loss following use of many products comprising D5 is expected following typical use application and corresponding wear time. Studies were conducted on three key product categories containing D5 (antiperspirants, skin care products and hair care products) to characterize the amount of D5 that may be destined to 'go down the drain' following simulated typical personal care use scenarios. Marketed antiperspirants and skin care products were applied to human subjects and hair care products were applied to human hair tressesand subsequently rinsed off at designated time points representative of typical consumer cleansing and personal hygiene habits. Wash water was collected at 0, 8 and 24h (antiperspirant and hair care analysis) and additionally at 4h (skin care analysis) post product application and samples were analyzed by isotope dilution headspace gas chromatography/mass spectrometry (GC/MS) to quantify the concentration of D5 destined to be available to go down the drain in captured wash water. It is demonstrated that significant amounts of D5 in 'leave-on' application products evaporate during typical use and that the concentration of D5 available to go down the drain under such conditions of use is only a very small (negligible) fraction of that delivered immediately upon product application. Copyright © 2012 Elsevier Ltd. All rights reserved.

Probability of Loss of Crew Achievability Studies for NASA's Exploration Systems Development

NASA Technical Reports Server (NTRS)

Boyer, Roger L.; Bigler, Mark; Rogers, James H.

2014-01-01

Over the last few years, NASA has been evaluating various vehicle designs for multiple proposed design reference missions (DRM) beyond low Earth orbit in support of its Exploration Systems Development (ESD) programs. This paper addresses several of the proposed missions and the analysis techniques used to assess the key risk metric, probability of loss of crew (LOC). Probability of LOC is a metric used to assess the safety risk as well as a design requirement. These risk assessments typically cover the concept phase of a DRM, i.e. when little more than a general idea of the mission is known and are used to help establish "best estimates" for proposed program and agency level risk requirements. These assessments or studies were categorized as LOC achievability studies to help inform NASA management as to what "ball park" estimates of probability of LOC could be achieved for each DRM and were eventually used to establish the corresponding LOC requirements. Given that details of the vehicles and mission are not well known at this time, the ground rules, assumptions, and consistency across the programs become the important basis of the assessments as well as for the decision makers to understand.

Probability of Loss of Crew Achievability Studies for NASA's Exploration Systems Development

NASA Technical Reports Server (NTRS)

Boyer, Roger L.; Bigler, Mark; Rogers, James H.

2015-01-01

Over the last few years, NASA has been evaluating various vehicle designs for multiple proposed design reference missions (DRM) beyond low Earth orbit in support of its Exploration Systems Development (ESD) programs. This paper addresses several of the proposed missions and the analysis techniques used to assess the key risk metric, probability of loss of crew (LOC). Probability of LOC is a metric used to assess the safety risk as well as a design requirement. These risk assessments typically cover the concept phase of a DRM, i.e. when little more than a general idea of the mission is known and are used to help establish "best estimates" for proposed program and agency level risk requirements. These assessments or studies were categorized as LOC achievability studies to help inform NASA management as to what "ball park" estimates of probability of LOC could be achieved for each DRM and were eventually used to establish the corresponding LOC requirements. Given that details of the vehicles and mission are not well known at this time, the ground rules, assumptions, and consistency across the programs become the important basis of the assessments as well as for the decision makers to understand.

Development of a cryogenic all-silicon telescope (CAIT)

NASA Astrophysics Data System (ADS)

McCarter, Douglas R.; McCarter, Eloise; Paquin, Roger

2012-09-01

Mankind loves space and is drawn to explore its vastness. Existing space telescopes routinely encounter data losses and delayed data collections during the constantly changing temperature and load disruptions of space missions. The harsh environment of space thermal cycles and spacecraft motion loads create unwanted activity such as spacecraft slew, acquisition slew, and temperature induced blur. In order to compensate for the low performance of the materials currently used for telescope optics, engineers and designers are using costly on-board coolers, mechanical actuators, and deformed mirrors, for example, with limited success. However, Zero-defect Single Crystal Silicon (SCSi) can perform in space environments without coolers, actuators, and other such devices because SCSi is not ductile and is homogeneous and therefore is not subject to creep, and will not jitter, or blur during operations. To take advantage of the unique advantages of Zero-defect SCSi, we are developing and fabricating a Cryostable All-Silicon Imaging Telescope (CAIT). In this paper, we will discuss the basis for selecting SCSi for our space telescope design, the status of the CAIT design and fabrication progress, and compare SCSi thermal and strength properties with other typical space optical materials.

Architectural design led approach to sustainable tourism for the waterfront development of Kunduchi in Tanzania

NASA Astrophysics Data System (ADS)

Leus, M.; Winkels, P.; Hannes, E.

2018-04-01

In Kunduchi, located in the Kinondoni district of the Dar es Salaam Region, it is of vital importance for the lives and livelihoods of the indigenous people to preserve the typical ecosystems and ensure the identity and economic resilience of these areas. The problem statement is as follows: In what way can sustainable tourism in Kunduchi serve as an engine for economic and social empowerment? How can Kunduchi be an inspiring example for the development of the coast of Dar Es Salaam in Tanzania that is threatened by large-scale tourist infrastructure? How to design sustainable solutions with respect for the local community and the local traditions? Firstly, a theoretical framework that connects sustainable tourism with the sustainable development of coastal areas is defined. Assumptions made on the basis of the literature review provide parameters that play an important role in the architectural concepts. Secondly, a research by design is presented in order to analyze and evaluate different scenarios to outline the opportunities of sustainable tourism on site of Kunduchi. Sustainable waterfront development is an obvious subtitle since the subtle spatial integration of these projects in the urban and water related context of Dares Salaam is of major importance.

40 CFR 228.15 - Dumping sites designated on a final basis.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Dumping sites designated on a final basis. 228.15 Section 228.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE MANAGEMENT OF DISPOSAL SITES FOR OCEAN DUMPING § 228.15 Dumping sites designated on a final basis. (a)(1) The sites...

40 CFR 228.15 - Dumping sites designated on a final basis.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Dumping sites designated on a final basis. 228.15 Section 228.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE MANAGEMENT OF DISPOSAL SITES FOR OCEAN DUMPING § 228.15 Dumping sites designated on a final basis. (a)(1) The sites...

40 CFR 228.15 - Dumping sites designated on a final basis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Dumping sites designated on a final basis. 228.15 Section 228.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE MANAGEMENT OF DISPOSAL SITES FOR OCEAN DUMPING § 228.15 Dumping sites designated on a final basis. (a)(1) The sites...

40 CFR 228.15 - Dumping sites designated on a final basis.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Dumping sites designated on a final basis. 228.15 Section 228.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE MANAGEMENT OF DISPOSAL SITES FOR OCEAN DUMPING § 228.15 Dumping sites designated on a final basis. (a)(1) The sites...

Design Rules for Life Support Systems

NASA Technical Reports Server (NTRS)

Jones, Harry

2002-01-01

This paper considers some of the common assumptions and engineering rules of thumb used in life support system design. One general design rule is that the longer the mission, the more the life support system should use recycling and regenerable technologies. A more specific rule is that, if the system grows more than half the food, the food plants will supply all the oxygen needed for the crew life support. There are many such design rules that help in planning the analysis of life support systems and in checking results. These rules are typically if-then statements describing the results of steady-state, "back of the envelope," mass flow calculations. They are useful in identifying plausible candidate life support system designs and in rough allocations between resupply and resource recovery. Life support system designers should always review the design rules and make quick steady state calculations before doing detailed design and dynamic simulation. This paper develops the basis for the different assumptions and design rules and discusses how they should be used. We start top-down, with the highest level requirement to sustain human beings in a closed environment off Earth. We consider the crew needs for air, water, and food. We then discuss atmosphere leakage and recycling losses. The needs to support the crew and to make up losses define the fundamental life support system requirements. We consider the trade-offs between resupplying and recycling oxygen, water, and food. The specific choices between resupply and recycling are determined by mission duration, presence of in-situ resources, etc., and are defining parameters of life support system design.

20 CFR 641.450 - Are there responsibility conditions that alone will disqualify an applicant?

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Additionally, significant fraud or criminal activity will typically include coordinated patterns or behaviors... a case-by-case basis regardless of what party identifies the alleged fraud or criminal activity. ...

Guidelines for freeway lighting curfews.

DOT National Transportation Integrated Search

2012-10-01

Roadway lighting is provided on selected highways to improve the visibility of the nighttime environment. : Roadway lighting is typically warranted on the basis of the daily traffic volume. However, in the earlymorning : hours, the traffic volumes ma...

Performance Measures for Public Participation Methods : Final Report

DOT National Transportation Integrated Search

2018-01-01

Public engagement is an important part of transportation project development, but measuring its effectiveness is typically piecemealed. Performance measurementdescribed by the Urban Institute as the measurement on a regular basis of the results (o...

NPR design basis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Locke, G.L.

1958-09-08

The design basis is composed of requirements and conditions for the design of the reactor plant (composed of the reactor and heat dissipation system). Its intent is to insure that the final product meets the economic, safety, and technical objectives of the project. The design basis is dependent on the ground rules, objectives, technical criteria, and practical design considerations. This document is being issued with the understanding that these items are not yet firmly established in all respects, and therefore, the numbers put down here are subject to change. Consideration of the spectrum of probable changes that might be mademore » leads to the conclusion that the numbers here are close to the final ones and are satisfactory as a basis for the initial stages of design. Some numbers are omitted because of insufficient data at this time.« less

Green Infrastructure Design Based on Spatial Conservation Prioritization and Modeling of Biodiversity Features and Ecosystem Services.

PubMed

Snäll, Tord; Lehtomäki, Joona; Arponen, Anni; Elith, Jane; Moilanen, Atte

2016-02-01

There is high-level political support for the use of green infrastructure (GI) across Europe, to maintain viable populations and to provide ecosystem services (ES). Even though GI is inherently a spatial concept, the modern tools for spatial planning have not been recognized, such as in the recent European Environment Agency (EEA) report. We outline a toolbox of methods useful for GI design that explicitly accounts for biodiversity and ES. Data on species occurrence, habitats, and environmental variables are increasingly available via open-access internet platforms. Such data can be synthesized by statistical species distribution modeling, producing maps of biodiversity features. These, together with maps of ES, can form the basis for GI design. We argue that spatial conservation prioritization (SCP) methods are effective tools for GI design, as the overall SCP goal is cost-effective allocation of conservation efforts. Corridors are currently promoted by the EEA as the means for implementing GI design, but they typically target the needs of only a subset of the regional species pool. SCP methods would help to ensure that GI provides a balanced solution for the requirements of many biodiversity features (e.g., species, habitat types) and ES simultaneously in a cost-effective manner. Such tools are necessary to make GI into an operational concept for combating biodiversity loss and promoting ES.

Green Infrastructure Design Based on Spatial Conservation Prioritization and Modeling of Biodiversity Features and Ecosystem Services

NASA Astrophysics Data System (ADS)

Snäll, Tord; Lehtomäki, Joona; Arponen, Anni; Elith, Jane; Moilanen, Atte

2016-02-01

There is high-level political support for the use of green infrastructure (GI) across Europe, to maintain viable populations and to provide ecosystem services (ES). Even though GI is inherently a spatial concept, the modern tools for spatial planning have not been recognized, such as in the recent European Environment Agency (EEA) report. We outline a toolbox of methods useful for GI design that explicitly accounts for biodiversity and ES. Data on species occurrence, habitats, and environmental variables are increasingly available via open-access internet platforms. Such data can be synthesized by statistical species distribution modeling, producing maps of biodiversity features. These, together with maps of ES, can form the basis for GI design. We argue that spatial conservation prioritization (SCP) methods are effective tools for GI design, as the overall SCP goal is cost-effective allocation of conservation efforts. Corridors are currently promoted by the EEA as the means for implementing GI design, but they typically target the needs of only a subset of the regional species pool. SCP methods would help to ensure that GI provides a balanced solution for the requirements of many biodiversity features (e.g., species, habitat types) and ES simultaneously in a cost-effective manner. Such tools are necessary to make GI into an operational concept for combating biodiversity loss and promoting ES.

Overview of clinical research design.

PubMed

Hartung, Daniel M; Touchette, Daniel

2009-02-15

Basic concepts and terminology of clinical research design are presented for new clinical investigators. Clinical research, research involving human subjects, can be described as either observational or experimental. The findings of all clinical research can be threatened by issues of bias and confounding. Biases are systematic errors in how study subjects are selected or measured, which result in false inferences. Confounding is a distortion in findings that is attributable to mixing variable effects. Uncontrolled observation research is generally more prone to bias and confounding than experimental research. Observational research includes designs such as the cohort study, case-control study, and cross-sectional study, while experimental research typically involves a randomized controlled trial (RCT). The cohort study, which includes the RCT, defines subject allocation on the basis of exposure interest (e.g., drug, disease-management program) and follows the patients to assess the outcomes. The case-control study uses the primary outcome of interest (e.g., adverse event) to define subject allocation, and different exposures are assessed in a retrospective manner. Cross-sectional research evaluates both exposure and outcome concurrently. Each of these design methods possesses different strengths and weaknesses in answering research questions, as well as underlying many study subtypes. While experimental research is the strongest method for establishing causality, it can be difficult to accomplish under many scenarios. Observational clinical research offers many design alternatives that may be appropriate if planned and executed carefully.

A Prototype SSVEP Based Real Time BCI Gaming System

PubMed Central

Martišius, Ignas

2016-01-01

Although brain-computer interface technology is mainly designed with disabled people in mind, it can also be beneficial to healthy subjects, for example, in gaming or virtual reality systems. In this paper we discuss the typical architecture, paradigms, requirements, and limitations of electroencephalogram-based gaming systems. We have developed a prototype three-class brain-computer interface system, based on the steady state visually evoked potentials paradigm and the Emotiv EPOC headset. An online target shooting game, implemented in the OpenViBE environment, has been used for user feedback. The system utilizes wave atom transform for feature extraction, achieving an average accuracy of 78.2% using linear discriminant analysis classifier, 79.3% using support vector machine classifier with a linear kernel, and 80.5% using a support vector machine classifier with a radial basis function kernel. PMID:27051414

Quantum Chemical Topology: Knowledgeable atoms in peptides

NASA Astrophysics Data System (ADS)

Popelier, Paul L. A.

2012-06-01

The need to improve atomistic biomolecular force fields remains acute. Fortunately, the abundance of contemporary computing power enables an overhaul of the architecture of current force fields, which typically base their electrostatics on fixed atomic partial charges. We discuss the principles behind the electrostatics of a more realistic force field under construction, called QCTFF. At the heart of QCTFF lies the so-called topological atom, which is a malleable box, whose shape and electrostatics changes in response to a changing environment. This response is captured by a machine learning method called Kriging. Kriging directly predicts each multipole moment of a given atom (i.e. the output) from the coordinates of the nuclei surrounding this atom (i.e. the input). This procedure yields accurate interatomic electrostatic energies, which form the basis for future-proof progress in force field design.

Full-scale 3-D finite element modeling of a two-loop pressurized water reactor for heat transfer, thermal–mechanical cyclic stress analysis, and environmental fatigue life estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohanty, Subhasish; Soppet, William K.; Majumdar, Saurindranath

This paper discusses a system-level finite element model of a two-loop pressurized water reactor (PWR). Based on this model, system-level heat transfer analysis and subsequent sequentially coupled thermal-mechanical stress analysis were performed for typical thermal-mechanical fatigue cycles. The in-air fatigue lives of example components, such as the hot and cold legs, were estimated on the basis of stress analysis results, ASME in-air fatigue life estimation criteria, and fatigue design curves. Furthermore, environmental correction factors and associated PWR environment fatigue lives for the hot and cold legs were estimated by using estimated stress and strain histories and the approach described inmore » US-NRC report: NUREG-6909.« less

Magnetically-induced forces on a ferromagnetic HT-9 first wall/blanket module

NASA Astrophysics Data System (ADS)

Lechtenberg, T. A.; Dahms, C. F.; Attaya, H.

1984-05-01

A model of the Starfire commercial tokamak reactor was used as the basis for calculating magnetic loads induced on typical fusion reactor first wall components fabricated of ferromagnetic material. The component analyzed was the first wall/blanket module because this structure experiences the greatest neutron fluence level and is the component for which the low swelling ferromagnetic Sandvik alloy, HT-9, may have the greatest benefit. The magnitudes of the magnetic body forces calculated were consistent with analyses performed on structures within other types of reactors. The loads generated within the module structure by the magnetic forces were found to be of the same order of magnitude as those arising from other sources such as pressure differential, dead weight, temperature distribution. Only small structural design modifications would be required if the magnetic alloy, Sandvik HT-9 were utilized.

Blood Irradiator Interactive Tool Beta Version

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howington, John; Potter, Charles; DeGroff, Tavias

The “Blood Irradiator Interactive Tool” compares a typical Cs-137 Blood Irradiator with that of the capabilities of an average X-ray Irradiator. It is designed to inform the user about the potential capabilities that an average X-ray Irradiator could offer them. Specifically the tool compares the amount of blood bags that can be irradiated by the users’ machine with that of the average X-ray capability. It also forcasts the amount of blood that can be irradiated on yearly basis for both the users’ machine and an average X-ray Device. The Average X-ray capabilities are taken from the three X-ray devices currentlymore » on the market: The RS 3400 Rad Source X-ray Blood Irradiator and both the 2.0L and 3.5 L versions of the Best Theratronis Raycell MK2« less

A Prototype SSVEP Based Real Time BCI Gaming System.

PubMed

Martišius, Ignas; Damaševičius, Robertas

2016-01-01

Although brain-computer interface technology is mainly designed with disabled people in mind, it can also be beneficial to healthy subjects, for example, in gaming or virtual reality systems. In this paper we discuss the typical architecture, paradigms, requirements, and limitations of electroencephalogram-based gaming systems. We have developed a prototype three-class brain-computer interface system, based on the steady state visually evoked potentials paradigm and the Emotiv EPOC headset. An online target shooting game, implemented in the OpenViBE environment, has been used for user feedback. The system utilizes wave atom transform for feature extraction, achieving an average accuracy of 78.2% using linear discriminant analysis classifier, 79.3% using support vector machine classifier with a linear kernel, and 80.5% using a support vector machine classifier with a radial basis function kernel.

Iron Containing Metal-Organic Frameworks: Structure, Synthesis, and Applications in Environmental Remediation.

PubMed

Liu, Xiaocheng; Zhou, Yaoyu; Zhang, Jiachao; Tang, Lin; Luo, Lin; Zeng, Guangming

2017-06-21

Metal-organic frameworks (MOFs) with Fe content are gradually developing into an independent branch in environmental remediation, requiring economical, effective, low-toxicity strategies to the complete procedure. In this review, recent advancements in the structure, synthesis, and environmental application focusing on the mechanism are presented. The unique structure of novel design proposed specific characteristics of different iron-containing MOFs with potential innovation. Synthesis of typical MILs, NH 2 -MILs and MILs based materials reveal the basis and defect of the current method, indicating the optimal means for the actual requirements. The adsorption of various contamination with multiple interaction as well as the catalytic degradation over radicals or electron-hole pairs are reviewed. This review implied considerable prospects of iron-containing MOFs in the field of environment and a more comprehensive cognition into the challenges and potential improvement.

Swahili speech development: preliminary normative data from typically developing pre-school children in Tanzania.

PubMed

Gangji, Nazneen; Pascoe, Michelle; Smouse, Mantoa

2015-01-01

Swahili is widely spoken in East Africa, but to date there are no culturally and linguistically appropriate materials available for speech-language therapists working in the region. The challenges are further exacerbated by the limited research available on the typical acquisition of Swahili phonology. To describe the speech development of 24 typically developing first language Swahili-speaking children between the ages of 3;0 and 5;11 years in Dar es Salaam, Tanzania. A cross-sectional design was used with six groups of four children in 6-month age bands. Single-word speech samples were obtained from each child using a set of culturally appropriate pictures designed to elicit all consonants and vowels of Swahili. Each child's speech was audio-recorded and phonetically transcribed using International Phonetic Alphabet (IPA) conventions. Children's speech development is described in terms of (1) phonetic inventory, (2) syllable structure inventory, (3) phonological processes and (4) percentage consonants correct (PCC) and percentage vowels correct (PVC). Results suggest a gradual progression in the acquisition of speech sounds and syllables between the ages of 3;0 and 5;11 years. Vowel acquisition was completed and most of the consonants acquired by age 3;0. Fricatives/z, s, h/ were later acquired at 4 years and /θ/and /r/ were the last acquired consonants at age 5;11. Older children were able to produce speech sounds more accurately and had fewer phonological processes in their speech than younger children. Common phonological processes included lateralization and sound preference substitutions. The study contributes a preliminary set of normative data on speech development of Swahili-speaking children. Findings are discussed in relation to theories of phonological development, and may be used as a basis for further normative studies with larger numbers of children and ultimately the development of a contextually relevant assessment of the phonology of Swahili-speaking children. © 2014 Royal College of Speech and Language Therapists.

A Design Basis for Spacecraft Cabin Trace Contaminant Control

NASA Technical Reports Server (NTRS)

Perry, Jay L.

2009-01-01

Successful trace chemical contamination control is one of the components necessary for achieving good cabin atmospheric quality. While employing seemingly simple process technologies, sizing the active contamination control equipment must employ a reliable design basis for the trace chemical load in the cabin atmosphere. A simplified design basis that draws on experience gained from the International Space Station program is presented. The trace chemical contamination control design load refines generation source magnitudes and includes key chemical functional groups representing both engineering and toxicology challenges.

A robust rotorcraft flight control system design methodology utilizing quantitative feedback theory

NASA Technical Reports Server (NTRS)

Gorder, Peter James

1993-01-01

Rotorcraft flight control systems present design challenges which often exceed those associated with fixed-wing aircraft. First, large variations in the response characteristics of the rotorcraft result from the wide range of airspeeds of typical operation (hover to over 100 kts). Second, the assumption of vehicle rigidity often employed in the design of fixed-wing flight control systems is rarely justified in rotorcraft where rotor degrees of freedom can have a significant impact on the system performance and stability. This research was intended to develop a methodology for the design of robust rotorcraft flight control systems. Quantitative Feedback Theory (QFT) was chosen as the basis for the investigation. Quantitative Feedback Theory is a technique which accounts for variability in the dynamic response of the controlled element in the design robust control systems. It was developed to address a Multiple-Input Single-Output (MISO) design problem, and utilizes two degrees of freedom to satisfy the design criteria. Two techniques were examined for extending the QFT MISO technique to the design of a Multiple-Input-Multiple-Output (MIMO) flight control system (FCS) for a UH-60 Black Hawk Helicopter. In the first, a set of MISO systems, mathematically equivalent to the MIMO system, was determined. QFT was applied to each member of the set simultaneously. In the second, the same set of equivalent MISO systems were analyzed sequentially, with closed loop response information from each loop utilized in subsequent MISO designs. The results of each technique were compared, and the advantages of the second, termed Sequential Loop Closure, were clearly evident.

Improved Steam Turbine Leakage Control with a Brush Seal Design

NASA Astrophysics Data System (ADS)

Turnquist, Norman; Chupp, Raymond E.; Pastrana, Ryan; Wolfe, Chris; Burnett, Mark

2002-10-01

This paper presents an improved steam turbine leakage control system with a brush seal design. The contents include: 1) Typical Design Characteristics; 2) Typical Brush Seal Locations; 3) Reduced Leakage Rates; 4) Performance Benefits; 5) System Considerations; 6) Rotor Dynamics; 7) Laboratory Tests and 8) Field Experience.

Predictive Ecotoxicology in the 21st Century

EPA Science Inventory

Ecological risk assessments have long relied on apical data on survival, growth/development, and reproduction, generated in animal toxicity tests and the application of uncertainty factors and conservative (typically) assumptions as a basis for decision-making. However, advances ...

[Groundwater organic pollution source identification technology system research and application].

PubMed

Wang, Xiao-Hong; Wei, Jia-Hua; Cheng, Zhi-Neng; Liu, Pei-Bin; Ji, Yi-Qun; Zhang, Gan

2013-02-01

Groundwater organic pollutions are found in large amount of locations, and the pollutions are widely spread once onset; which is hard to identify and control. The key process to control and govern groundwater pollution is how to control the sources of pollution and reduce the danger to groundwater. This paper introduced typical contaminated sites as an example; then carried out the source identification studies and established groundwater organic pollution source identification system, finally applied the system to the identification of typical contaminated sites. First, grasp the basis of the contaminated sites of geological and hydrogeological conditions; determine the contaminated sites characteristics of pollutants as carbon tetrachloride, from the large numbers of groundwater analysis and test data; then find the solute transport model of contaminated sites and compound-specific isotope techniques. At last, through groundwater solute transport model and compound-specific isotope technology, determine the distribution of the typical site of organic sources of pollution and pollution status; invest identified potential sources of pollution and sample the soil to analysis. It turns out that the results of two identified historical pollution sources and pollutant concentration distribution are reliable. The results provided the basis for treatment of groundwater pollution.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, R.P.; Kincaid, R.H.; Short, S.A.

This report presents the results of part of a two-task study on the engineering characterization of earthquake ground motion for nuclear power plant design. Task I of the study, which is presented in NUREG/CR-3805, Vol. 1, developed a basis for selecting design response spectra taking into account the characteristics of free-field ground motion found to be significant in causing structural damage. Task II incorporates additional considerations of effects of spatial variations of ground motions and soil-structure interaction on foundation motions and structural response. The results of Task II are presented in four parts: (1) effects of ground motion characteristics onmore » structural response of a typical PWR reactor building with localized nonlinearities and soil-structure interaction effects; (2) empirical data on spatial variations of earthquake ground motion; (3) soil-structure interaction effects on structural response; and (4) summary of conclusions and recommendations based on Tasks I and II studies. This report presents the results of the first part of Task II. The results of the other parts will be presented in NUREG/CR-3805, Vols. 3 to 5.« less

Strategic development of a multivariate calibration model for the uniformity testing of tablets by transmission NIR analysis.

PubMed

Sasakura, D; Nakayama, K; Sakamoto, T; Chikuma, T

2015-05-01

The use of transmission near infrared spectroscopy (TNIRS) is of particular interest in the pharmaceutical industry. This is because TNIRS does not require sample preparation and can analyze several tens of tablet samples in an hour. It has the capability to measure all relevant information from a tablet, while still on the production line. However, TNIRS has a narrow spectrum range and overtone vibrations often overlap. To perform content uniformity testing in tablets by TNIRS, various properties in the tableting process need to be analyzed by a multivariate prediction model, such as a Partial Least Square Regression modeling. One issue is that typical approaches require several hundred reference samples to act as the basis of the method rather than a strategically designed method. This means that many batches are needed to prepare the reference samples; this requires time and is not cost effective. Our group investigated the concentration dependence of the calibration model with a strategic design. Consequently, we developed a more effective approach to the TNIRS calibration model than the existing methodology.

Binders for Energetics - Modelling and Synthesis in Harmony

NASA Astrophysics Data System (ADS)

Dossi, Licia; Cleaver, Doug; Gould, Peter; Dunnett, Jim; Cavaye, Hamish; Ellison, Laurence; Luppi, Federico; Hollands, Ron; Bradley, Mark

The Binders by Design UK programme develop new polymeric materials for energetic applications that can overcome problems related to chemico-physical properties, aging, additives, environmental and performance of energetic compositions. Combined multi-scale modelling and experiment is used for the development of a new modelling tool and with the aim to produce novel materials with great confidence and fast turnaround. New synthesised binders with attractive properties for energetic applications used to provide a high level of confidence in the results of developed models. Molecular dynamics simulations investigate the thermal behaviour and the results directly feed into a Group Interaction Model (GIM). A viscoelastic constitutive model has been developed examining stress development in energetic/binder configurations. GIM data has been used as the basis for developing hydrocode equations of state, which then applied in run-to-detonation type investigations to examine the effect of the shock properties of a binder on the reactivity of a typical Polymer Bonded Explosive in a high-velocity impact type scenario. The Binders by Design UK programme is funded through the Weapons Science and Technology Centre by DSTL.

Comparison of l₁-Norm SVR and Sparse Coding Algorithms for Linear Regression.

PubMed

Zhang, Qingtian; Hu, Xiaolin; Zhang, Bo

2015-08-01

Support vector regression (SVR) is a popular function estimation technique based on Vapnik's concept of support vector machine. Among many variants, the l1-norm SVR is known to be good at selecting useful features when the features are redundant. Sparse coding (SC) is a technique widely used in many areas and a number of efficient algorithms are available. Both l1-norm SVR and SC can be used for linear regression. In this brief, the close connection between the l1-norm SVR and SC is revealed and some typical algorithms are compared for linear regression. The results show that the SC algorithms outperform the Newton linear programming algorithm, an efficient l1-norm SVR algorithm, in efficiency. The algorithms are then used to design the radial basis function (RBF) neural networks. Experiments on some benchmark data sets demonstrate the high efficiency of the SC algorithms. In particular, one of the SC algorithms, the orthogonal matching pursuit is two orders of magnitude faster than a well-known RBF network designing algorithm, the orthogonal least squares algorithm.

Optimizing spectral CT parameters for material classification tasks

NASA Astrophysics Data System (ADS)

Rigie, D. S.; La Rivière, P. J.

2016-06-01

In this work, we propose a framework for optimizing spectral CT imaging parameters and hardware design with regard to material classification tasks. Compared with conventional CT, many more parameters must be considered when designing spectral CT systems and protocols. These choices will impact material classification performance in a non-obvious, task-dependent way with direct implications for radiation dose reduction. In light of this, we adapt Hotelling Observer formalisms typically applied to signal detection tasks to the spectral CT, material-classification problem. The result is a rapidly computable metric that makes it possible to sweep out many system configurations, generating parameter optimization curves (POC’s) that can be used to select optimal settings. The proposed model avoids restrictive assumptions about the basis-material decomposition (e.g. linearity) and incorporates signal uncertainty with a stochastic object model. This technique is demonstrated on dual-kVp and photon-counting systems for two different, clinically motivated material classification tasks (kidney stone classification and plaque removal). We show that the POC’s predicted with the proposed analytic model agree well with those derived from computationally intensive numerical simulation studies.

Method for fracturing silicon-carbide coatings on nuclear-fuel particles

DOEpatents

Turner, Lloyd J.; Willey, Melvin G.; Tiegs, Sue M.; Van Cleve, Jr., John E.

1982-01-01

This invention is a device for fracturing particles. It is designed especially for use in "hot cells" designed for the handling of radioactive materials. In a typical application, the device is used to fracture a hard silicon-carbide coating present on carbon-matrix microspheres containing nuclear-fuel material, such as uranium or thorium compounds. To promote remote control and facilitate maintenance, the particle breaker is pneumatically operated and contains no moving parts. It includes means for serially entraining the entrained particles on an anvil housed in a leak-tight chamber. The flow rate of the gas is at a value effecting fracture of the particles; preferably, it is at a value fracturing them into product particulates of fluidizable size. The chamber is provided with an outlet passage whose cross-sectional area decreases in the direction away from the chamber. The outlet is connected tangentially to a vertically oriented vortex-flow separator for recovering the product particulates entrained in the gas outflow from the chamber. The invention can be used on a batch or continuous basis to fracture the silicon-carbide coatings on virtually all of the particles fed thereto.

Optimizing Spectral CT Parameters for Material Classification Tasks

PubMed Central

Rigie, D. S.; La Rivière, P. J.

2017-01-01

In this work, we propose a framework for optimizing spectral CT imaging parameters and hardware design with regard to material classification tasks. Compared with conventional CT, many more parameters must be considered when designing spectral CT systems and protocols. These choices will impact material classification performance in a non-obvious, task-dependent way with direct implications for radiation dose reduction. In light of this, we adapt Hotelling Observer formalisms typically applied to signal detection tasks to the spectral CT, material-classification problem. The result is a rapidly computable metric that makes it possible to sweep out many system configurations, generating parameter optimization curves (POC’s) that can be used to select optimal settings. The proposed model avoids restrictive assumptions about the basis-material decomposition (e.g. linearity) and incorporates signal uncertainty with a stochastic object model. This technique is demonstrated on dual-kVp and photon-counting systems for two different, clinically motivated material classification tasks (kidney stone classification and plaque removal). We show that the POC’s predicted with the proposed analytic model agree well with those derived from computationally intensive numerical simulation studies. PMID:27227430

Enabling Object Storage via shims for Grid Middleware

NASA Astrophysics Data System (ADS)

Cadellin Skipsey, Samuel; De Witt, Shaun; Dewhurst, Alastair; Britton, David; Roy, Gareth; Crooks, David

2015-12-01

The Object Store model has quickly become the basis of most commercially successful mass storage infrastructure, backing so-called ”Cloud” storage such as Amazon S3, but also underlying the implementation of most parallel distributed storage systems. Many of the assumptions in Object Store design are similar, but not identical, to concepts in the design of Grid Storage Elements, although the requirement for ”POSIX-like” filesystem structures on top of SEs makes the disjunction seem larger. As modern Object Stores provide many features that most Grid SEs do not (block level striping, parallel access, automatic file repair, etc.), it is of interest to see how easily we can provide interfaces to typical Object Stores via plugins and shims for Grid tools, and how well experiments can adapt their data models to them. We present evaluation of, and first-deployment experiences with, (for example) Xrootd-Ceph interfaces for direct object-store access, as part of an initiative within GridPP[1] hosted at RAL. Additionally, we discuss the tradeoffs and experience of developing plugins for the currently-popular Ceph parallel distributed filesystem for the GFAL2 access layer, at Glasgow.

Device for fracturing silicon-carbide coatings on nuclear-fuel particles

DOEpatents

Turner, L.J.; Willey, M.G.; Tiegs, S.M.; Van Cleve, J.E. Jr.

This invention is a device for fracturing particles. It is designed especially for use in hot cells designed for the handling of radioactive materials. In a typical application, the device is used to fracture a hard silicon-carbide coating present on carbon-matrix microspheres containing nuclear-fuel materials, such as uranium or thorium compounds. To promote remote control and facilitate maintenance, the particle breaker is pneumatically operated and contains no moving parts. It includes means for serially entraining the entrained particles on an anvil housed in a leak-tight chamber. The flow rate of the gas is at a value effecting fracture of the particles; preferably, it is at a value fracturing them into product particulates of fluidizable size. The chamber is provided with an outlet passage whose cross-sectional area decreases in the direction away from the chamber. The outlet is connected tangentially to a vertically oriented vortex-flow separator for recovering the product particulates entrained in the gas outflow from the chamber. The invention can be used on a batch or continuous basis to fracture the silicon-carbide coatings on virtually all of the particles fed thereto.

Process wastewater treatability study for Westinghouse fluidized-bed coal gasification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winton, S.L.; Buvinger, B.J.; Evans, J.M.

1983-11-01

In the development of a synthetic fuels facility, water usage and wastewater treatment are major areas of concern. Coal gasification processes generally produce relatively large volumes of gas condensates. These wastewaters are typically composed of a variety of suspended and dissolved organic and inorganic solids and dissolved gaseous contaminants. Fluidized-bed coal gasification (FBG) processes are no exception to this rule. The Department of Energy's Morgantown Energy Technology Center (METC), the Gas Research Institute (GRI), and the Environmental Protection Agency (EPA/IERLRTP) recognized the need for a FBG treatment program to provide process design data for FBG wastewaters during the environmental, health,more » and safety characterization of the Westinghouse Process Development Unit (PDU). In response to this need, METC developed conceptual designs and a program plan to obtain process design and performance data for treating wastewater from commercial-scale Westinghouse-based synfuels plants. As a result of this plan, METC, GRI, and EPA entered into a joint program to develop performance data, design parameters, conceptual designs, and cost estimates for treating wastewaters from a FBG plant. Wastewater from the Westinghouse PDU consists of process quench and gas cooling condensates which are similar to those produced by other FBG processes such as U-Gas, and entrained-bed gasification processes such as Texaco. Therefore, wastewater from this facility was selected as the basis for this study. This paper outlines the current program for developing process design and cost data for the treatment of these wastewaters.« less

The design and fabrication of a prototype trash compacting unit. [for long duration space missions

NASA Technical Reports Server (NTRS)

1973-01-01

A prototype trash compactor, that is compatible with the anticipated requirements of future long-term space missions, is described. Preliminary problem definition studies were conducted to identify typical types and quantities of waste materials to be expected from a typical mission. Bench-scale compaction tests were then conducted on typical waste materials to determine force/compaction curves. These data were used to design a boilerplate compactor that was fabricated to prove the feasibility of the basic design concept. A final design was then prepared from which the deliverable unit was fabricated. Design concepts are presented for suggested further development of the compactor, including a version that is capable of handling wet biodegradable wastes.

Poster — Thur Eve — 27: Flattening Filter Free VMAT Quality Assurance: Dose Rate Considerations for Detector Response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Viel, Francis; Duzenli, Cheryl; British Columbia Cancer Agency, Department of Medical Physics, Vancouver Centre

2014-08-15

Introduction: Radiation detector responses can be affected by dose rate. Due to higher dose per pulse and wider range of mu rates in FFF beams, detector responses should be characterized prior to implementation of QA protocols for FFF beams. During VMAT delivery, the MU rate may also vary dramatically within a treatment fraction. This study looks at the dose per pulse variation throughout a 3D volume for typical VMAT plans and the response characteristics for a variety of detectors, and makes recommendations on the design of QA protocols for FFF VMAT QA. Materials and Methods: Linac log file data andmore » a simplified dose calculation algorithm are used to calculate dose per pulse for a variety of clinical VMAT plans, on a voxel by voxel basis, as a function of time in a cylindrical phantom. Diode and ion chamber array responses are characterized over the relevant range of dose per pulse and dose rate. Results: Dose per pulse ranges from <0.1 mGy/pulse to 1.5 mGy/pulse in a typical VMAT treatment delivery using the 10XFFF beam. Diode detector arrays demonstrate increased sensitivity to dose (+./− 3%) with increasing dose per pulse over this range. Ion chamber arrays demonstrate decreased sensitivity to dose (+/− 1%) with increasing dose rate over this range. Conclusions: QA protocols should be designed taking into consideration inherent changes in detector sensitivity with dose rate. Neglecting to account for changes in detector response with dose per pulse can lead to skewed QA results.« less

Distributed Group Design Process: Lessons Learned.

ERIC Educational Resources Information Center

Eseryel, Deniz; Ganesan, Radha

A typical Web-based training development team consists of a project manager, an instructional designer, a subject-matter expert, a graphic artist, and a Web programmer. The typical scenario involves team members working together in the same setting during the entire design and development process. What happens when the team is distributed, that is…

Simulant Basis for the Standard High Solids Vessel Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Reid A.; Fiskum, Sandra K.; Suffield, Sarah R.

The Waste Treatment and Immobilization Plant (WTP) is working to develop a Standard High Solids Vessel Design (SHSVD) process vessel. To support testing of this new design, WTP engineering staff requested that a Newtonian simulant and a non-Newtonian simulant be developed that would represent the Most Adverse Design Conditions (in development) with respect to mixing performance as specified by WTP. The majority of the simulant requirements are specified in 24590-PTF-RPT-PE-16-001, Rev. 0. The first step in this process is to develop the basis for these simulants. This document describes the basis for the properties of these two simulant types. Themore » simulant recipes that meet this basis will be provided in a subsequent document.« less

78 FR 24786 - Notice of Funding Availability for the Department of Transportation's National Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

..., engineering or design work and purchasing existing facilities or right-of-way. 3. Livability: Increasing... Feasibility: The technical feasibility of the project should be demonstrated by engineering and design studies and activities; the development of design criteria and/or a basis of design; the basis for the cost...

Improved Algorithm For Finite-Field Normal-Basis Multipliers

NASA Technical Reports Server (NTRS)

Wang, C. C.

1989-01-01

Improved algorithm reduces complexity of calculations that must precede design of Massey-Omura finite-field normal-basis multipliers, used in error-correcting-code equipment and cryptographic devices. Algorithm represents an extension of development reported in "Algorithm To Design Finite-Field Normal-Basis Multipliers" (NPO-17109), NASA Tech Briefs, Vol. 12, No. 5, page 82.

75 FR 54918 - Draft Regulatory Guide, DG-1247, “Design-Basis Hurricane and Hurricane Missiles for Nuclear Power...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... that the staff uses in evaluating specific problems or postulated accidents, and data that the staff... turbine missiles. NUREG/CR 7004 is the technical basis for regulatory guidance on design-basis hurricane... hurricane wind speeds for new nuclear power plants. [[Page 54919

Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips

PubMed Central

Jung, Woo-Chul; Heo, Young-Moo; Yoon, Gil-Sang; Shin, Kwang-Ho; Chang, Sung-Ho; Kim, Gun-Hee; Cho, Myeong-Woo

2007-01-01

Recently, the polymeric micro-fluidic biochip, often called LOC (lab-on-a-chip), has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. It becomes possible to form miniaturized lab functionalities on a chip with the development of MEMS technologies. The micro-fluidic chips contain many micro-channels for the flow of sample and reagents, mixing, and detection tasks. Typical substrate materials for the chip are glass and polymers. Typical techniques for microfluidic chip fabrication are utilizing various micro pattern forming methods, such as wet-etching, micro-contact printing, and hot-embossing, micro injection molding, LIGA, and micro powder blasting processes, etc. In this study, to establish the basis of the micro pattern fabrication and mass production of polymeric micro-fluidic chips using injection molding process, micro machining method was applied to form micro-channels on the LOC molds. In the research, a series of machining experiments using micro end-mills were performed to determine optimum machining conditions to improve surface roughness and shape accuracy of designed simplified micro-channels. Obtained conditions were used to machine required mold inserts for micro-channels using micro end-mills. Test injection processes using machined molds and COC polymer were performed, and then the results were investigated.

Sensitivity to Morphosyntactic Information in 3-Year-Old Children With Typical Language Development: A Feasibility Study.

PubMed

Deevy, Patricia; Leonard, Laurence B; Marchman, Virginia A

2017-03-01

This study tested the feasibility of a method designed to assess children's sensitivity to tense/agreement information in fronted auxiliaries during online comprehension of questions (e.g., Are the nice little dogs running?). We expected that a group of children who were proficient in auxiliary use would show this sensitivity, indicating an awareness of the relation between the subject-verb sequence (e.g., dogs running) and preceding information (e.g., are). Failure to grasp this relation is proposed to play a role in the protracted inconsistency in auxiliary use in children with specific language impairment (SLI). Fifteen 3-year-old typically developing children who demonstrated proficiency in auxiliary use viewed pairs of pictures showing a single agent and multiple agents while hearing questions with or without an agreeing fronted auxiliary. Proportion looking to the target was measured. Children showed anticipatory looking on the basis of the number information contained in the auxiliary (is or are). The children tested in this study represent a group that frequently serves as a comparison for older children with SLI. Because the method successfully demonstrated their sensitivity to tense/agreement information in questions, future research that involves direct comparisons of these 2 groups is warranted.

Optimising in situ gamma measurements to identify the presence of radioactive particles in land areas.

PubMed

Rostron, Peter D; Heathcote, John A; Ramsey, Michael H

2014-12-01

High-coverage in situ surveys with gamma detectors are the best means of identifying small hotspots of activity, such as radioactive particles, in land areas. Scanning surveys can produce rapid results, but the probabilities of obtaining false positive or false negative errors are often unknown, and they may not satisfy other criteria such as estimation of mass activity concentrations. An alternative is to use portable gamma-detectors that are set up at a series of locations in a systematic sampling pattern, where any positive measurements are subsequently followed up in order to determine the exact location, extent and nature of the target source. The preliminary survey is typically designed using settings of detector height, measurement spacing and counting time that are based on convenience, rather than using settings that have been calculated to meet requirements. This paper introduces the basis of a repeatable method of setting these parameters at the outset of a survey, for pre-defined probabilities of false positive and false negative errors in locating spatially small radioactive particles in land areas. It is shown that an un-collimated detector is more effective than a collimated detector that might typically be used in the field. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Investigating Extreme Lifestyles through Mangrove Transcriptomics

ERIC Educational Resources Information Center

Dassanayake, Maheshi

2009-01-01

Mangroves represent phylogenetically diverse taxa in tropical coastal terrestrial habitats. They are extremophiles, evolutionarily adapted to tolerate flooding, anoxia, high temperatures, wind, and high and extremely variable salt conditions in typically resource-poor environments. The genetic basis for these adaptations is, however, virtually…

Methodology for the systems engineering process. Volume 3: Operational availability

NASA Technical Reports Server (NTRS)

Nelson, J. H.

1972-01-01

A detailed description and explanation of the operational availability parameter is presented. The fundamental mathematical basis for operational availability is developed, and its relationship to a system's overall performance effectiveness is illustrated within the context of identifying specific availability requirements. Thus, in attempting to provide a general methodology for treating both hypothetical and existing availability requirements, the concept of an availability state, in conjunction with the more conventional probability-time capability, is investigated. In this respect, emphasis is focused upon a balanced analytical and pragmatic treatment of operational availability within the system design process. For example, several applications of operational availability to typical aerospace systems are presented, encompassing the techniques of Monte Carlo simulation, system performance availability trade-off studies, analytical modeling of specific scenarios, as well as the determination of launch-on-time probabilities. Finally, an extensive bibliography is provided to indicate further levels of depth and detail of the operational availability parameter.

Microoptical System And Fabrication Method Therefor

DOEpatents

Sweatt, William C.; Christenson, Todd R.

2005-03-15

Microoptical systems with clear aperture of about one millimeter or less are fabricated from a layer of photoresist using a lithographic process to define the optical elements. A deep X-ray source is typically used to expose the photoresist. Exposure and development of the photoresist layer can produce planar, cylindrical, and radially symmetric micro-scale optical elements, comprising lenses, mirrors, apertures, diffractive elements, and prisms, monolithically formed on a common substrate with the mutual optical alignment required to provide the desired system functionality. Optical alignment can be controlled to better than one micron accuracy. Appropriate combinations of structure and materials enable optical designs that include corrections for chromatic and other optical aberrations. The developed photoresist can be used as the basis for a molding operation to produce microoptical systems made of a range of optical materials. Finally, very complex microoptical systems can be made with as few as three lithographic exposures.

Characterization and Modeling of Nonfilamentary Ta/TaOx/TiO2/Ti Analog Synaptic Device

PubMed Central

Wang, Yu-Fen; Lin, Yen-Chuan; Wang, I-Ting; Lin, Tzu-Ping; Hou, Tuo-Hung

2015-01-01

A two-terminal analog synaptic device that precisely emulates biological synaptic features is expected to be a critical component for future hardware-based neuromorphic computing. Typical synaptic devices based on filamentary resistive switching face severe limitations on the implementation of concurrent inhibitory and excitatory synapses with low conductance and state fluctuation. For overcoming these limitations, we propose a Ta/TaOx/TiO2/Ti device with superior analog synaptic features. A physical simulation based on the homogeneous (nonfilamentary) barrier modulation induced by oxygen ion migration accurately reproduces various DC and AC evolutions of synaptic states, including the spike-timing-dependent plasticity and paired-pulse facilitation. Furthermore, a physics-based compact model for facilitating circuit-level design is proposed on the basis of the general definition of memristor devices. This comprehensive experimental and theoretical study of the promising electronic synapse can facilitate realizing large-scale neuromorphic systems. PMID:25955658

Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling

PubMed Central

Podgornaia, Anna I.; Casino, Patricia; Marina, Alberto; Laub, Michael T.

2013-01-01

Summary Two-component signal transduction systems typically involve a sensor histidine kinase that specifically phosphorylates a single, cognate response regulator. This protein-protein interaction relies on molecular recognition via a small set of residues in each protein. To better understand how these residues determine the specificity of kinase-substrate interactions, we rationally rewired the interaction interface of a Thermotoga maritima two-component system, HK853-RR468, to match that found in a different two-component system, E. coli PhoR-PhoB. The rewired proteins interacted robustly with each other, but no longer interacted with the parent proteins. Analysis of the crystal structures of the wild-type and mutant protein complexes, along with a systematic mutagenesis study, reveals how individual mutations contribute to the rewiring of interaction specificity. Our approach and conclusions have implications for studies of other protein-protein interactions, protein evolution, and the design of novel protein interfaces. PMID:23954504

Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materials

DOEpatents

Boucheron, Laura E

2013-07-16

Quantitative object and spatial arrangement-level analysis of tissue are detailed using expert (pathologist) input to guide the classification process. A two-step method is disclosed for imaging tissue, by classifying one or more biological materials, e.g. nuclei, cytoplasm, and stroma, in the tissue into one or more identified classes on a pixel-by-pixel basis, and segmenting the identified classes to agglomerate one or more sets of identified pixels into segmented regions. Typically, the one or more biological materials comprises nuclear material, cytoplasm material, and stromal material. The method further allows a user to markup the image subsequent to the classification to re-classify said materials. The markup is performed via a graphic user interface to edit designated regions in the image.

Development of noSQL data storage for the ATLAS PanDA Monitoring System

NASA Astrophysics Data System (ADS)

Potekhin, M.; ATLAS Collaboration

2012-06-01

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with a R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic loads.

A case-association cluster detection and visualisation tool with an application to Legionnaires’ disease

PubMed Central

Sansom, P; Copley, V R; Naik, F C; Leach, S; Hall, I M

2013-01-01

Statistical methods used in spatio-temporal surveillance of disease are able to identify abnormal clusters of cases but typically do not provide a measure of the degree of association between one case and another. Such a measure would facilitate the assignment of cases to common groups and be useful in outbreak investigations of diseases that potentially share the same source. This paper presents a model-based approach, which on the basis of available location data, provides a measure of the strength of association between cases in space and time and which is used to designate and visualise the most likely groupings of cases. The method was developed as a prospective surveillance tool to signal potential outbreaks, but it may also be used to explore groupings of cases in outbreak investigations. We demonstrate the method by using a historical case series of Legionnaires’ disease amongst residents of England and Wales. PMID:23483594

Simplification rules for birdtrack operators

NASA Astrophysics Data System (ADS)

Alcock-Zeilinger, J.; Weigert, H.

2017-05-01

This paper derives a set of easy-to-use tools designed to simplify calculations with birdtrack operators comprised of symmetrizers and antisymmetrizers. In particular, we present cancellation rules allowing one to shorten the birdtrack expressions of operators and propagation rules identifying the circumstances under which it is possible to propagate symmetrizers past antisymmetrizers and vice versa. We exhibit the power of these simplification rules by means of a short example in which we apply the tools derived in this paper on a typical operator that can be encountered in the representation theory of 𝖲𝖴 (N ) over the product space V⊗m. These rules form the basis for the construction of compact Hermitian Young projection operators and their transition operators addressed in companion papers [J. Alcock-Zeilinger and H. Weigert, "Compact Hermitian Young projection operators," e-print arXiv:1610.10088 [math-ph] and J. Alcock-Zeilinger and H. Weigert, "Transition operators," e-print arXiv:1610.08802 [math-ph

Microoptical system and fabrication method therefor

DOEpatents

Sweatt, William C.; Christenson, Todd R.

2003-07-08

Microoptical systems with clear aperture of about one millimeter or less are fabricated from a layer of photoresist using a lithographic process to define the optical elements. A deep X-ray source is typically used to expose the photoresist. Exposure and development of the photoresist layer can produce planar, cylindrical, and radially symmetric micro-scale optical elements, comprising lenses, mirrors, apertures, diffractive elements, and prisms, monolithically formed on a common substrate with the mutual optical alignment required to provide the desired system functionality. Optical alignment can be controlled to better than one micron accuracy. Appropriate combinations of structure and materials enable optical designs that include corrections for chromatic and other optical aberrations. The developed photoresist can be used as the basis for a molding operation to produce microoptical systems made of a range of optical materials. Finally, very complex microoptical systems can be made with as few as three lithographic exposures.

Metallurgical Plant Optimization Through the use of Flowsheet Simulation Modelling

NASA Astrophysics Data System (ADS)

Kennedy, Mark William

Modern metallurgical plants typically have complex flowsheets and operate on a continuous basis. Real time interactions within such processes can be complex and the impacts of streams such as recycles on process efficiency and stability can be highly unexpected prior to actual operation. Current desktop computing power, combined with state-of-the-art flowsheet simulation software like Metsim, allow for thorough analysis of designs to explore the interaction between operating rate, heat and mass balances and in particular the potential negative impact of recycles. Using plant information systems, it is possible to combine real plant data with simple steady state models, using dynamic data exchange links to allow for near real time de-bottlenecking of operations. Accurate analytical results can also be combined with detailed unit operations models to allow for feed-forward model-based-control. This paper will explore some examples of the application of Metsim to real world engineering and plant operational issues.

Reliability Analysis of Sealing Structure of Electromechanical System Based on Kriging Model

NASA Astrophysics Data System (ADS)

Zhang, F.; Wang, Y. M.; Chen, R. W.; Deng, W. W.; Gao, Y.

2018-05-01

The sealing performance of aircraft electromechanical system has a great influence on flight safety, and the reliability of its typical seal structure is analyzed by researcher. In this paper, we regard reciprocating seal structure as a research object to study structural reliability. Having been based on the finite element numerical simulation method, the contact stress between the rubber sealing ring and the cylinder wall is calculated, and the relationship between the contact stress and the pressure of the hydraulic medium is built, and the friction force on different working conditions are compared. Through the co-simulation, the adaptive Kriging model obtained by EFF learning mechanism is used to describe the failure probability of the seal ring, so as to evaluate the reliability of the sealing structure. This article proposes a new idea of numerical evaluation for the reliability analysis of sealing structure, and also provides a theoretical basis for the optimal design of sealing structure.

Design of a Resistively Heated Thermal Hydraulic Simulator for Nuclear Rocket Reactor Cores

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Ramachandran, Narayanan; Wang, Ten-See; Anghaie, Samim

2007-01-01

A preliminary design study is presented for a non-nuclear test facility which uses ohmic heating to replicate the thermal hydraulic characteristics of solid core nuclear reactor fuel element passages. The basis for this testing capability is a recently commissioned nuclear thermal rocket environments simulator, which uses a high-power, multi-gas, wall-stabilized constricted arc-heater to produce high-temperature pressurized hydrogen flows representative of reactor core environments, excepting radiation effects. Initially, the baseline test fixture for this non-nuclear environments simulator was configured for long duration hot hydrogen exposure of small cylindrical material specimens as a low cost means of evaluating material compatibility. It became evident, however, that additional functionality enhancements were needed to permit a critical examination of thermal hydraulic effects in fuel element passages. Thus, a design configuration was conceived whereby a short tubular material specimen, representing a fuel element passage segment, is surrounded by a backside resistive tungsten heater element and mounted within a self-contained module that inserts directly into the baseline test fixture assembly. With this configuration, it becomes possible to create an inward directed radial thermal gradient within the tubular material specimen such that the wall-to-gas heat flux characteristics of a typical fuel element passage are effectively simulated. The results of a preliminary engineering study for this innovative concept are fully summarized, including high-fidelity multi-physics thermal hydraulic simulations and detailed design features.

Evaluating Intention and Effect: The Impact of Healthcare Facility Design on Patient and Staff Well-Being.

PubMed

Alvaro, Celeste; Wilkinson, Andrea J; Gallant, Sara N; Kostovski, Deyan; Gardner, Paula

2016-01-01

This post occupancy evaluation (POE) assessed the impact of architectural design on psychosocial well-being among patients and staff in the context of a new complex continuing care and rehabilitation facility. Departing from typical POEs, the hospital design intentions formed the theoretical basis to assess outcomes. Intentions included creating an environment of wellness; enhancing connection to the community, the city, and nature; enhancing opportunities for social interaction; and inspiring activity. A pretest-posttest quasi experiment, including quantitative surveys, assessed the impact of the building design on well-being outcomes across three facilities-the new hospital, the former hospital, and a comparison facility with a similar population. With the exception of connection to neighborhood (for patients) and opportunities to visit with others (for staff) and wayfinding (for patients and staff), impressions of the new hospital mirrored the design intentions relative to the former hospital and the comparison facility among patients and staff. Perceptions of improvement in mental health, self-efficacy in mobility, satisfaction, and interprofessional interactions were enhanced at the new hospital relative to the former hospital, whereas optimism, depressive symptoms, general well-being, burnout, and intention to quit did not vary. Interestingly, patients and staff with favorable impressions of the building design fared better on most well-being-related outcomes relative to those with less favorable impressions. Beyond the value of assessing the impact of the design intentions on outcomes, the approach used in this study would benefit evaluation strategies across a diversity of health and other public and large-scale buildings. © The Author(s) 2015.

A Basis for Determining the Adequacy of Evaluation Designs

ERIC Educational Resources Information Center

Sanders, James R.; Nafziger, Dean N.

2011-01-01

The purpose of this paper is to provide a basis for judging the adequacy of evaluation plans or, as they are commonly called, evaluation designs. The authors assume that using the procedures suggested in this paper to determine the adequacy of evaluation designs in advance of actually conducting evaluations will lead to better evaluation designs,…

Calibration of Clinical Audio Recording and Analysis Systems for Sound Intensity Measurement.

PubMed

Maryn, Youri; Zarowski, Andrzej

2015-11-01

Sound intensity is an important acoustic feature of voice/speech signals. Yet recordings are performed with different microphone, amplifier, and computer configurations, and it is therefore crucial to calibrate sound intensity measures of clinical audio recording and analysis systems on the basis of output of a sound-level meter. This study was designed to evaluate feasibility, validity, and accuracy of calibration methods, including audiometric speech noise signals and human voice signals under typical speech conditions. Calibration consisted of 3 comparisons between data from 29 measurement microphone-and-computer systems and data from the sound-level meter: signal-specific comparison with audiometric speech noise at 5 levels, signal-specific comparison with natural voice at 3 levels, and cross-signal comparison with natural voice at 3 levels. Intensity measures from recording systems were then linearly converted into calibrated data on the basis of these comparisons, and validity and accuracy of calibrated sound intensity were investigated. Very strong correlations and quasisimilarity were found between calibrated data and sound-level meter data across calibration methods and recording systems. Calibration of clinical sound intensity measures according to this method is feasible, valid, accurate, and representative for a heterogeneous set of microphones and data acquisition systems in real-life circumstances with distinct noise contexts.

Diagnosis of Parkinson’s disease on the basis of clinical–genetic classification: a population-based modelling study

PubMed Central

Nalls, Mike A.; McLean, Cory Y.; Rick, Jacqueline; Eberly, Shirley; Hutten, Samantha J.; Gwinn, Katrina; Sutherland, Margaret; Martinez, Maria; Heutink, Peter; Williams, Nigel; Hardy, John; Gasser, Thomas; Brice, Alexis; Price, T. Ryan; Nicolas, Aude; Keller, Margaux F.; Molony, Cliona; Gibbs, J. Raphael; Chen-Plotkin, Alice; Suh, Eunran; Letson, Christopher; Fiandaca, Massimo S.; Mapstone, Mark; Federoff, Howard J.; Noyce, Alastair J; Morris, Huw; Van Deerlin, Vivianna M.; Weintraub, Daniel; Zabetian, Cyrus; Hernandez, Dena G.; Lesage, Suzanne; Mullins, Meghan; Conley, Emily Drabant; Northover, Carrie; Frasier, Mark; Marek, Ken; Day-Williams, Aaron G.; Stone, David J.; Ioannidis, John P. A.; Singleton, Andrew B.

2015-01-01

Background Accurate diagnosis and early detection of complex disease has the potential to be of enormous benefit to clinical trialists, patients, and researchers alike. We sought to create a non-invasive, low-cost, and accurate classification model for diagnosing Parkinson’s disease risk to serve as a basis for future disease prediction studies in prospective longitudinal cohorts. Methods We developed a simple disease classifying model within 367 patients with Parkinson’s disease and phenotypically typical imaging data and 165 controls without neurological disease of the Parkinson’s Progression Marker Initiative (PPMI) study. Olfactory function, genetic risk, family history of PD, age and gender were algorithmically selected as significant contributors to our classifying model. This model was developed using the PPMI study then tested in 825 patients with Parkinson’s disease and 261 controls from five independent studies with varying recruitment strategies and designs including the Parkinson’s Disease Biomarkers Program (PDBP), Parkinson’s Associated Risk Study (PARS), 23andMe, Longitudinal and Biomarker Study in PD (LABS-PD), and Morris K. Udall Parkinson’s Disease Research Center of Excellence (Penn-Udall). Findings Our initial model correctly distinguished patients with Parkinson’s disease from controls at an area under the curve (AUC) of 0.923 (95% CI = 0.900 – 0.946) with high sensitivity (0.834, 95% CI = 0.711 – 0.883) and specificity (0.903, 95% CI = 0.824 – 0.946) in PPMI at its optimal AUC threshold (0.655). The model is also well-calibrated with all Hosmer-Lemeshow simulations suggesting that when parsed into random subgroups, the actual data mirrors that of the larger expected data, demonstrating that our model is robust and fits well. Likewise external validation shows excellent classification of PD with AUCs of 0.894 in PDBP, 0.998 in PARS, 0.955 in 23andMe, 0.929 in LABS-PD, and 0.939 in Penn-Udall. Additionally, when our model classifies SWEDD as PD, they convert within one year to typical PD more than would be expected by chance, with 4 out of 17 classified as PD converting to PD during brief follow-up; while SWEDD not classified as PD showed one conversion to PD out of 38 participants (test of proportions, p-value = 0.003). Interpretation This model may serve as a basis for future investigations into the classification, prediction and treatment of Parkinson’s disease, particularly those planning on attempting to identify prodromal or preclinical etiologically typical PD cases in prospective cohorts for efficient interventional and biomarker studies. Funding Please see the acknowledgements and funding section at the end of the manuscript. PMID:26271532

Sample diversity and premise typicality in inductive reasoning: evidence for developmental change.

PubMed

Rhodes, Marjorie; Brickman, Daniel; Gelman, Susan A

2008-08-01

Evaluating whether a limited sample of evidence provides a good basis for induction is a critical cognitive task. We hypothesized that whereas adults evaluate the inductive strength of samples containing multiple pieces of evidence by attending to the relations among the exemplars (e.g., sample diversity), six-year-olds would attend to the degree to which each individual exemplar in a sample independently appears informative (e.g., premise typicality). To test these hypotheses, participants were asked to select between diverse and non-diverse samples to help them learn about basic-level animal categories. Across various between-subject conditions (N=133), we varied the typicality present in the diverse and non-diverse samples. We found that adults reliably selected to examine diverse over non-diverse samples, regardless of exemplar typicality, six-year-olds preferred to examine samples containing typical exemplars, regardless of sample diversity, and nine-year-olds were somewhat in the midst of this developmental transition.

Development of thermal models of footwear using finite element analysis.

PubMed

Covill, D; Guan, Z W; Bailey, M; Raval, H

2011-03-01

Thermal comfort is increasingly becoming a crucial factor to be considered in footwear design. The climate inside a shoe is controlled by thermal and moisture conditions and is crucial to attain comfort. Research undertaken has shown that thermal conditions play a dominant role in shoe climate. Development of thermal models that are capable of predicting in-shoe temperature distributions is an effective way forward to undertake extensive parametric studies to assist optimized design. In this paper, two-dimensional and three-dimensional thermal models of in-shoe climate were developed using finite element analysis through commercial code Abaqus. The thermal material properties of the upper shoe, sole, and air were considered. Dry heat flux from the foot was calculated on the basis of typical blood flow in the arteries on the foot. Using the thermal models developed, in-shoe temperatures were predicted to cover various locations for controlled ambient temperatures of 15, 25, and 35 degrees C respectively. The predicted temperatures were compared with multipoint measured temperatures through microsensor technology. Reasonably good correlation was obtained, with averaged errors of 6, 2, and 1.5 per cent, based on the averaged in-shoe temperature for the above three ambient temperatures. The models can be further used to help design shoes with optimized thermal comfort.

Learning a novel phonological contrast depends on interactions between individual differences and training paradigm design

PubMed Central

Perrachione, Tyler K.; Lee, Jiyeon; Ha, Louisa Y. Y.; Wong, Patrick C. M.

2011-01-01

Studies evaluating phonological contrast learning typically investigate either the predictiveness of specific pretraining aptitude measures or the efficacy of different instructional paradigms. However, little research considers how these factors interact—whether different students learn better from different types of instruction—and what the psychological basis for any interaction might be. The present study demonstrates that successfully learning a foreign-language phonological contrast for pitch depends on an interaction between individual differences in perceptual abilities and the design of the training paradigm. Training from stimuli with high acoustic-phonetic variability is generally thought to improve learning; however, we found high-variability training enhanced learning only for individuals with strong perceptual abilities. Learners with weaker perceptual abilities were actually impaired by high-variability training relative to a low-variability condition. A second experiment assessing variations on the high-variability training design determined that the property of this learning environment most detrimental to perceptually weak learners is the amount of trial-by-trial variability. Learners’ perceptual limitations can thus override the benefits of high-variability training where trial-by-trial variability in other irrelevant acoustic-phonetic features obfuscates access to the target feature. These results demonstrate the importance of considering individual differences in pretraining aptitudes when evaluating the efficacy of any speech training paradigm. PMID:21786912

A methodology to derive Synthetic Design Hydrographs for river flood management

NASA Astrophysics Data System (ADS)

Tomirotti, Massimo; Mignosa, Paolo

2017-12-01

The design of flood protection measures requires in many cases not only the estimation of the peak discharges, but also of the volume of the floods and its time distribution. A typical solution to this kind of problems is the formulation of Synthetic Design Hydrographs (SDHs). In this paper a methodology to derive SDHs is proposed on the basis of the estimation of the Flow Duration Frequency (FDF) reduction curve and of a Peak-Duration (PD) relationship furnishing respectively the quantiles of the maximum average discharge and the average peak position in each duration. The methodology is intended to synthesize the main features of the historical floods in a unique SDH for each return period. The shape of the SDH is not selected a priori but is a result of the behaviour of FDF and PD curves, allowing to account in a very convenient way for the variability of the shapes of the observed hydrographs at local time scale. The validation of the methodology is performed with reference to flood routing problems in reservoirs, lakes and rivers. The results obtained demonstrate the capability of the SDHs to describe the effects of different hydraulic systems on the statistical regime of floods, even in presence of strong modifications induced on the probability distribution of peak flows.

An overview of urban stormwater-management practices in Miami-Dade County, Florida

USGS Publications Warehouse

Chin, David A.

2004-01-01

Agencies with jurisdiction over stormwater-management systems in Miami-Dade County, Florida, include the Miami-Dade Department of Environmental Resources Management (DERM), South Florida Water Management District (SFWMD), and Florida Department of Transportation (FDOT). These agencies are primarily concerned with minor drainage systems that handle runoff from storms with return periods of 10 years or less (DERM), major drainage systems that handle runoff from storms with return periods of 25 years or more (SFWMD), and runoff from major roadways (FDOT). All drainage regulations require retention of at least a specified water-quality volume (defined volume of surface runoff), typically the first inch of runoff. The DERM and FDOT intensity duration frequency (IDF) curves used as a basis for design are similar but different, with differences particularly apparent for short-duration storms. The SFWMD 25-year 3-day storm incorporates an IDF curve that is substantially different from both the IDF curves of DERM and FDOT. A DERM methodology for designing closed exfiltration systems is applicable to storms of 1-hour duration, but is not applicable to all storms with a given T-year return period. A trench design that is applicable to all storms with a given T-year return period is presented as an alternative approach.

10 CFR 50.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... to bring and maintain the plant in safe shutdown (non-design basis accident). Applicant means a... Document Control Desk. Nuclear reactor means an apparatus, other than an atomic weapon, designed or used to... from the Restricted Data category pursuant to section 142 of the Act. Safe shutdown (non-design basis...

10 CFR 50.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... to bring and maintain the plant in safe shutdown (non-design basis accident). Applicant means a... Document Control Desk. Nuclear reactor means an apparatus, other than an atomic weapon, designed or used to... from the Restricted Data category pursuant to section 142 of the Act. Safe shutdown (non-design basis...

10 CFR 50.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... to bring and maintain the plant in safe shutdown (non-design basis accident). Applicant means a... Document Control Desk. Nuclear reactor means an apparatus, other than an atomic weapon, designed or used to... from the Restricted Data category pursuant to section 142 of the Act. Safe shutdown (non-design basis...

10 CFR 50.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... to bring and maintain the plant in safe shutdown (non-design basis accident). Applicant means a... Document Control Desk. Nuclear reactor means an apparatus, other than an atomic weapon, designed or used to... from the Restricted Data category pursuant to section 142 of the Act. Safe shutdown (non-design basis...

Initial evaluation of discrete orthogonal basis reconstruction of ECT images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moody, E.B.; Donohue, K.D.

1996-12-31

Discrete orthogonal basis restoration (DOBR) is a linear, non-iterative, and robust method for solving inverse problems for systems characterized by shift-variant transfer functions. This simulation study evaluates the feasibility of using DOBR for reconstructing emission computed tomographic (ECT) images. The imaging system model uses typical SPECT parameters and incorporates the effects of attenuation, spatially-variant PSF, and Poisson noise in the projection process. Sample reconstructions and statistical error analyses for a class of digital phantoms compare the DOBR performance for Hartley and Walsh basis functions. Test results confirm that DOBR with either basis set produces images with good statistical properties. Nomore » problems were encountered with reconstruction instability. The flexibility of the DOBR method and its consistent performance warrants further investigation of DOBR as a means of ECT image reconstruction.« less

Real-time combustion monitoring of PCDD/F indicators by REMPI-TOFMS

EPA Science Inventory

Analyses for polychlorinated dibenzodioxin and dibenzofuran (PCDD/F) emissions typically require a 4 h extractive sample taken on an annual or less frequent basis. This results in a potentially minimally representative monitoring scheme. More recently, methods for continual sampl...

Convergence studies of deterministic methods for LWR explicit reflector methodology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canepa, S.; Hursin, M.; Ferroukhi, H.

2013-07-01

The standard approach in modem 3-D core simulators, employed either for steady-state or transient simulations, is to use Albedo coefficients or explicit reflectors at the core axial and radial boundaries. In the latter approach, few-group homogenized nuclear data are a priori produced with lattice transport codes using 2-D reflector models. Recently, the explicit reflector methodology of the deterministic CASMO-4/SIMULATE-3 code system was identified to potentially constitute one of the main sources of errors for core analyses of the Swiss operating LWRs, which are all belonging to GII design. Considering that some of the new GIII designs will rely on verymore » different reflector concepts, a review and assessment of the reflector methodology for various LWR designs appeared as relevant. Therefore, the purpose of this paper is to first recall the concepts of the explicit reflector modelling approach as employed by CASMO/SIMULATE. Then, for selected reflector configurations representative of both GII and GUI designs, a benchmarking of the few-group nuclear data produced with the deterministic lattice code CASMO-4 and its successor CASMO-5, is conducted. On this basis, a convergence study with regards to geometrical requirements when using deterministic methods with 2-D homogenous models is conducted and the effect on the downstream 3-D core analysis accuracy is evaluated for a typical GII deflector design in order to assess the results against available plant measurements. (authors)« less

Food consumption and buying patterns of students from a Philippine university fastfood mall.

PubMed

Patricia, M; Azanza, V

2001-11-01

A consumer survey was conducted in a university fastfood mall to determine the food consumption and buying patterns of Philippine university students. The survey established that a typical fastfood consumer in the test university foodmall is female between 16 and 22 years old, with a purchasing capability of < or = US$1.79 for a complete meal, and who generally frequents the mall only once a day during weekdays. Wholesomeness, affordability and variety of the foods were the general basis for satisfaction of the typical student consumer.

Mineral resource of the month: hydraulic cement

USGS Publications Warehouse

van Oss, Hendrik G.

2012-01-01

Hydraulic cements are the binders in concrete and most mortars and stuccos. Concrete, particularly the reinforced variety, is the most versatile of all construction materials, and most of the hydraulic cement produced worldwide is portland cement or similar cements that have portland cement as a basis, such as blended cements and masonry cements. Cement typically makes up less than 15 percent of the concrete mix; most of the rest is aggregates. Not counting the weight of reinforcing media, 1 ton of cement will typically yield about 8 tons of concrete.

Alternative method of quantum state tomography toward a typical target via a weak-value measurement

NASA Astrophysics Data System (ADS)

Chen, Xi; Dai, Hong-Yi; Yang, Le; Zhang, Ming

2018-03-01

There is usually a limitation of weak interaction on the application of weak-value measurement. This limitation dominates the performance of the quantum state tomography toward a typical target in the finite and high-dimensional complex-valued superposition of its basis states, especially when the compressive sensing technique is also employed. Here we propose an alternative method of quantum state tomography, presented as a general model, toward such typical target via weak-value measurement to overcome such limitation. In this model the pointer for the weak-value measurement is a qubit, and the target-pointer coupling interaction is no longer needed within the weak interaction limitation, meanwhile this interaction under the compressive sensing can be described with the Taylor series of the unitary evolution operator. The postselection state at the target is the equal superposition of all basis states, and the pointer readouts are gathered under multiple Pauli operator measurements. The reconstructed quantum state is generated from an optimization algorithm of total variation augmented Lagrangian alternating direction algorithm. Furthermore, we demonstrate an example of this general model for the quantum state tomography toward the planar laser-energy distribution and discuss the relations among some parameters at both our general model and the original first-order approximate model for this tomography.

Process Metallurgy an Enabler of Resource Efficiency: Linking Product Design to Metallurgy in Product Centric Recycling

NASA Astrophysics Data System (ADS)

Reuter, Markus; van Schaik, Antoinette

In this paper the link between process metallurgy, classical minerals processing, product centric recycling and urban/landfill mining is discussed. The depth that has to be achieved in urban mining and recycling must glean from the wealth of theoretical knowledge and insight that have been developed in the past in minerals and metallurgical processing. This background learns that recycling demands a product centric approach, which considers simultaneously the multi-material interactions in man-made complex `minerals'. Fast innovation in recycling and urban mining can be achieved by further evolving from this well developed basis, evolving the techniques and tools that have been developed over the years. This basis has already been used for many years to design, operate and control industrial plants for metal production. This has been the basis for Design for Recycling rules for End-of-Life products. Using, among others, the UNEP Metal Recycling report as a basis (authors are respectively Lead and Main authors of report), it is demonstrated that a common theoretical basis as developed in metallurgy and minerals processing can help much to level the playing field between primary processing, secondary processing, recycling, and urban/landfill mining and product design hence enhancing resource efficiency. Thus various scales of detail link product design with metallurgical process design and its fundamentals.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walston, S; Rowland, M; Campbell, K

It is difficult to track to the location of a melted core in a GE BWR with Mark I containment during a beyond-design-basis accident. The Cooper Nuclear Station provided a baseline of normal material distributions and shielding configurations for the GE BWR with Mark I containment. Starting with source terms for a design-basis accident, methods and remote observation points were investigated to allow tracking of a melted core during a beyond-design-basis accident. The design of the GE BWR with Mark-I containment highlights an amazing poverty of expectations regarding a common mode failure of all reactor core cooling systems resulting inmore » a beyond-design-basis accident from the simple loss of electric power. This design is shown in Figure 1. The station blackout accident scenario has been consistently identified as the leading contributor to calculated probabilities for core damage. While NRC-approved models and calculations provide guidance for indirect methods to assess core damage during a beyond-design-basis loss-of-coolant accident (LOCA), there appears to be no established method to track the location of the core directly should the LOCA include a degree of fuel melt. We came to the conclusion that - starting with detailed calculations which estimate the release and movement of gaseous and soluble fission products from the fuel - selected dose readings in specific rooms of the reactor building should allow the location of the core to be verified.« less

Cerebellar abiotrophy in a family of Border Collie dogs.

PubMed

Sandy, J R; Slocombe, R E; Mitten, R W; Jedwab, D

2002-11-01

Cerebellar abiotrophies have a nonsex-linked, autosomal, recessively inherited basis in a number of species, and lesions typically reflect profound and progressive loss of Purkinje cells. In this report, an unusual form of abiotrophy is described for two sibling Border Collies. Extensive loss of the cerebellar granular cell layer was present with relative sparing of Purkinje cells of two female pups. The biochemical basis for this form of cerebellar abiotrophy is unknown, but the lack of disease in other siblings supports an autosomal recessive mode of inheritance.

An Application of Gröbner Basis in Differential Equations of Physics

NASA Astrophysics Data System (ADS)

Chaharbashloo, Mohammad Saleh; Basiri, Abdolali; Rahmany, Sajjad; Zarrinkamar, Saber

2013-11-01

We apply the Gröbner basis to the ansatz method in quantum mechanics to obtain the energy eigenvalues and the wave functions in a very simple manner. There are important physical potentials such as the Cornell interaction which play significant roles in particle physics and can be treated via this technique. As a typical example, the algorithm is applied to the semi-relativistic spinless Salpeter equation under the Cornell interaction. Many other applications of the idea in a wide range of physical fields are listed as well.

Attention Deficits: Current Concepts, Controversies, Management, and Approaches to Classroom Instruction.

ERIC Educational Resources Information Center

Busch, Betsy

1993-01-01

This article reviews diagnostic criteria for attention deficit hyperactivity disorder and undifferentiated attention deficit disorder; typical presenting features; theories of the biological basis of attentional disorders; and treatments, including medical treatments with stimulants and tricyclic antidepressants and nonmedical treatments such as…

An audible automobile back-up pedestrian warning device--development and evaluation

DOT National Transportation Integrated Search

1976-11-01

The purpose of the study was to develop and field-test an audible back-up warning device for use on automobiles. Detailed criteria of pedestrian age and hearing ability combined with noise characteristics of typical accident sites provide the basis f...

Spacecraft high-voltage power supply construction

NASA Technical Reports Server (NTRS)

Sutton, J. F.; Stern, J. E.

1975-01-01

The design techniques, circuit components, fabrication techniques, and past experience used in successful high-voltage power supplies for spacecraft flight systems are described. A discussion of the basic physics of electrical discharges in gases is included and a design rationale for the prevention of electrical discharges is provided. Also included are typical examples of proven spacecraft high-voltage power supplies with typical specifications for design, fabrication, and testing.

Brain basis of phonological awareness for spoken language in children and its disruption in dyslexia.

PubMed

Kovelman, Ioulia; Norton, Elizabeth S; Christodoulou, Joanna A; Gaab, Nadine; Lieberman, Daniel A; Triantafyllou, Christina; Wolf, Maryanne; Whitfield-Gabrieli, Susan; Gabrieli, John D E

2012-04-01

Phonological awareness, knowledge that speech is composed of syllables and phonemes, is critical for learning to read. Phonological awareness precedes and predicts successful transition from language to literacy, and weakness in phonological awareness is a leading cause of dyslexia, but the brain basis of phonological awareness for spoken language in children is unknown. We used functional magnetic resonance imaging to identify the neural correlates of phonological awareness using an auditory word-rhyming task in children who were typical readers or who had dyslexia (ages 7-13) and a younger group of kindergarteners (ages 5-6). Typically developing children, but not children with dyslexia, recruited left dorsolateral prefrontal cortex (DLPFC) when making explicit phonological judgments. Kindergarteners, who were matched to the older children with dyslexia on standardized tests of phonological awareness, also recruited left DLPFC. Left DLPFC may play a critical role in the development of phonological awareness for spoken language critical for reading and in the etiology of dyslexia.

76 FR 63541 - Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... Hurricane Missiles for Nuclear Power Plants AGENCY: Nuclear Regulatory Commission. ACTION: Regulatory guide... regulatory guide, (RG) 1.221, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants... missiles that a nuclear power plant should be designed to withstand to prevent undue risk to the health and...

Classification of Types of Stuttering Symptoms Based on Brain Activity

PubMed Central

Jiang, Jing; Lu, Chunming; Peng, Danling; Zhu, Chaozhe; Howell, Peter

2012-01-01

Among the non-fluencies seen in speech, some are more typical (MT) of stuttering speakers, whereas others are less typical (LT) and are common to both stuttering and fluent speakers. No neuroimaging work has evaluated the neural basis for grouping these symptom types. Another long-debated issue is which type (LT, MT) whole-word repetitions (WWR) should be placed in. In this study, a sentence completion task was performed by twenty stuttering patients who were scanned using an event-related design. This task elicited stuttering in these patients. Each stuttered trial from each patient was sorted into the MT or LT types with WWR put aside. Pattern classification was employed to train a patient-specific single trial model to automatically classify each trial as MT or LT using the corresponding fMRI data. This model was then validated by using test data that were independent of the training data. In a subsequent analysis, the classification model, just established, was used to determine which type the WWR should be placed in. The results showed that the LT and the MT could be separated with high accuracy based on their brain activity. The brain regions that made most contribution to the separation of the types were: the left inferior frontal cortex and bilateral precuneus, both of which showed higher activity in the MT than in the LT; and the left putamen and right cerebellum which showed the opposite activity pattern. The results also showed that the brain activity for WWR was more similar to that of the LT and fluent speech than to that of the MT. These findings provide a neurological basis for separating the MT and the LT types, and support the widely-used MT/LT symptom grouping scheme. In addition, WWR play a similar role as the LT, and thus should be placed in the LT type. PMID:22761887

Consequence analysis in LPG installation using an integrated computer package.

PubMed

Ditali, S; Colombi, M; Moreschini, G; Senni, S

2000-01-07

This paper presents the prototype of the computer code, Atlantide, developed to assess the consequences associated with accidental events that can occur in a LPG storage plant. The characteristic of Atlantide is to be simple enough but at the same time adequate to cope with consequence analysis as required by Italian legislation in fulfilling the Seveso Directive. The application of Atlantide is appropriate for LPG storage/transferring installations. The models and correlations implemented in the code are relevant to flashing liquid releases, heavy gas dispersion and other typical phenomena such as BLEVE/Fireball. The computer code allows, on the basis of the operating/design characteristics, the study of the relevant accidental events from the evaluation of the release rate (liquid, gaseous and two-phase) in the unit involved, to the analysis of the subsequent evaporation and dispersion, up to the assessment of the final phenomena of fire and explosion. This is done taking as reference simplified Event Trees which describe the evolution of accidental scenarios, taking into account the most likely meteorological conditions, the different release situations and other features typical of a LPG installation. The limited input data required and the automatic linking between the single models, that are activated in a defined sequence, depending on the accidental event selected, minimize both the time required for the risk analysis and the possibility of errors. Models and equations implemented in Atlantide have been selected from public literature or in-house developed software and tailored with the aim to be easy to use and fast to run but, nevertheless, able to provide realistic simulation of the accidental event as well as reliable results, in terms of physical effects and hazardous areas. The results have been compared with those of other internationally recognized codes and with the criteria adopted by Italian authorities to verify the Safety Reports for LPG installations. A brief of the theoretical basis of each model implemented in Atlantide and an example of application are included in the paper.

Human Factors and Modeling Methods in the Development of Control Room Modernization Concepts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hugo, Jacques V.; Slay III, Lorenzo

nuclear power plants. Although the nuclear industry has made steady improvement in outage optimization, each day of a refueling outage still represents an opportunity to save millions of dollars and each day an outage extends past its planned end date represents millions of dollars that may have been spent unnecessarily. Reducing planned outage duration or preventing outage extensions requires careful management of the outage schedule as well as constant oversight and monitoring of work completion during the outage execution. During a typical outage, there are typically more than 10,000 activities on the schedule that, if not managed efficiently, may causemore » expensive outage delays. Management of outages currently relies largely on paper-based resources and general-purpose office software. A typical tool currently used to monitor work performance is a burn-down curve, where total remaining activities are plotted against the baseline schedule to track bulk work completion progress. While these tools are useful, there is still considerable uncertainty during a typical outage that bulk work progress is adequate and therefore a lot of management time is spent analyzing the situation on a daily basis. This paper describes recent advances made in developing a framework for the design of visual outage information presentation, as well as an overview of the scientific principles that informed the development of the visualizations. To test the utility of advanced visual outage information presentation, an outage management dashboard software application was created as part of the Department of Energy’s Advanced Outage Control Center project. This dashboard is intended to present all the critical information an outage manager would need to understand the current status of a refueling outage. The dashboard presents the critical path, bulk work performance, key performance indicators, outage milestones and metrics relating current performance to historical performance. Additionally, the dashboard includes data analysis tools to allow outage managers to drill down into the underlying data to understand the drivers of the indicators.« less

Pavement design and performance studies : progress report no. 4 on phase A, performance study of typical Virginia pavements.

DOT National Transportation Integrated Search

1970-01-01

The performance of in-service typical Virginia flexible and rigid pavements in all areas of the state is under evaluation. The objectives are to provide a ready reference for designers and field engineers and to provide background information for des...

Functional Internet Literacy: Required Cognitive Skills with Implications for Instruction

ERIC Educational Resources Information Center

Johnson, Genevieve Marie

2007-01-01

Patterns of typical Internet use provide the basis for defining "functional Internet literacy." Internet use commonly includes communication, information, recreation, and commercial activities. Technical competence with connectivity, security, and downloads is a prerequisite for using the Internet for such activities. Bloom's taxonomy of cognitive…

A transcriptome analysis of two grapevine populations segregating for tendril phyllotaxy

USDA-ARS?s Scientific Manuscript database

The shoot structure of cultivated grapevine Vitis vinifera L. typically exhibits a 3-node modular repetitive pattern, two sequential leaf-opposed tendrils followed by a tendril-free node. In this study, we investigated the molecular basis of this pattern by characterizing differentially expressed ge...

[System for automating primary examinations of the public in a polyclinic].

PubMed

Drozhzhin, V M; Orlov, A Iu; Polkovnikov, V D; Rukavishnikov, V D; Isaĭkin, V A

1984-01-01

Presented in the paper is an automated system for original examinations of population in a typical outpatient clinic. Main functional parameters and specifications are given. The system is capable of managing the data basis for the region with population of 50 000 inhabitants.

Structural fabrication quality as a factor of industrial facilities safety

NASA Astrophysics Data System (ADS)

Tishkov, E. V.; Kardaev, E. M.; Stolbova, S. Yu; Shishova, O. S.

2018-04-01

In the conditions of industrial facilities high wear degree, it is very important to ensure the possibility of their safe operation in order to avoid various kinds of accidents and catastrophes. As practice shows, industrial plant collapses can occur suddenly under normal operating conditions. Usually, such accidents can take place at different stages of structures life cycle. One of the reasons for this is the initially low quality of reinforced concrete structures fabrication. The article considers the factors contributing to the collapse of reinforced concrete structures of water purification tanks located on the territory of the Omsk Region. The main surveys results on tank structures after collapse with the use of ultrasonic and physical methods of investigation are presented. On the basis of the obtained data analysis, it was found that the main cause of the accidents was the insufficient load-bearing capacity of typical reinforced concrete structures, caused by defects in their fabrication in the factory conditions because of exceeding the standard displacement from the design position of the working reinforcement. Recommendations are given on the identification of defective structures and the prevention of similar accidents when operating similar tanks at manufacturing plants constructed from standard designs.

Parabolic solar concentrator

NASA Astrophysics Data System (ADS)

Tecpoyotl-Torres, M.; Campos-Alvarez, J.; Tellez-Alanis, F.; Sánchez-Mondragón, J.

2006-08-01

In this work we present the basis of the solar concentrator design, which has is located at Temixco, Morelos, Mexico. For this purpose, this place is ideal due to its geographic and climatic conditions, and in addition, because it accounts with the greatest constant illumination in Mexico. For the construction of the concentrator we use a recycled parabolic plate of a telecommunications satellite dish (NEC). This plate was totally covered with Aluminum. The opening diameter is of 332 cm, the focal length is of 83 cm and the opening angle is of 90°. The geometry of the plate guaranties that the incident beams, will be collected at the focus. The mechanical treatment of the plate produces an average reflectance of 75% in the visible region of the solar spectrum, and of 92% for wavelengths up to 3μm in the infrared region. We obtain up to 2000°C of temperature concentration with this setup. The reflectance can be greatly improved, but did not consider it as typical practical use. The energy obtained can be applied to conditions that require of those high calorific energies. In order to optimize the operation of the concentrator we use a control circuit designed to track the apparent sun position.

Multi-criteria decision model for retrofitting existing buildings

NASA Astrophysics Data System (ADS)

Bostenaru Dan, M. D.

2004-08-01

Decision is an element in the risk management process. In this paper the way how science can help in decision making and implementation for retrofitting buildings in earthquake prone urban areas is investigated. In such interventions actors from various spheres are involved. Their interests range among minimising the intervention for maximal preservation or increasing it for seismic safety. Research was conducted to see how to facilitate collaboration between these actors. A particular attention was given to the role of time in actors' preferences. For this reason, on decision level, both the processural and the personal dimension of risk management, the later seen as a task, were considered. A systematic approach was employed to determine the functional structure of a participative decision model. Three layers on which actors implied in this multi-criteria decision problem interact were identified: town, building and element. So-called 'retrofit elements' are characteristic bearers in the architectural survey, engineering simulations, costs estimation and define the realms perceived by the inhabitants. This way they represent an interaction basis for the interest groups considered in a deeper study. Such orientation means for actors' interaction were designed on other levels of intervention as well. Finally, an 'experiment' for the implementation of the decision model is presented: a strategic plan for an urban intervention towards reduction of earthquake hazard impact through retrofitting. A systematic approach proves thus to be a very good communication basis among the participants in the seismic risk management process. Nevertheless, it can only be applied in later phases (decision, implementation, control) only, since it serves verifying and improving solution and not developing the concept. The 'retrofit elements' are a typical example of the detailing degree reached in the retrofit design plans in these phases.

Quasi-continuous stochastic simulation framework for flood modelling

NASA Astrophysics Data System (ADS)

Moustakis, Yiannis; Kossieris, Panagiotis; Tsoukalas, Ioannis; Efstratiadis, Andreas

2017-04-01

Typically, flood modelling in the context of everyday engineering practices is addressed through event-based deterministic tools, e.g., the well-known SCS-CN method. A major shortcoming of such approaches is the ignorance of uncertainty, which is associated with the variability of soil moisture conditions and the variability of rainfall during the storm event.In event-based modeling, the sole expression of uncertainty is the return period of the design storm, which is assumed to represent the acceptable risk of all output quantities (flood volume, peak discharge, etc.). On the other hand, the varying antecedent soil moisture conditions across the basin are represented by means of scenarios (e.g., the three AMC types by SCS),while the temporal distribution of rainfall is represented through standard deterministic patterns (e.g., the alternative blocks method). In order to address these major inconsistencies,simultaneously preserving the simplicity and parsimony of the SCS-CN method, we have developed a quasi-continuous stochastic simulation approach, comprising the following steps: (1) generation of synthetic daily rainfall time series; (2) update of potential maximum soil moisture retention, on the basis of accumulated five-day rainfall; (3) estimation of daily runoff through the SCS-CN formula, using as inputs the daily rainfall and the updated value of soil moisture retention;(4) selection of extreme events and application of the standard SCS-CN procedure for each specific event, on the basis of synthetic rainfall.This scheme requires the use of two stochastic modelling components, namely the CastaliaR model, for the generation of synthetic daily data, and the HyetosMinute model, for the disaggregation of daily rainfall to finer temporal scales. Outcomes of this approach are a large number of synthetic flood events, allowing for expressing the design variables in statistical terms and thus properly evaluating the flood risk.

Performance of NACA Eight-Stage Axial-Flow Compressor Designed on the Basis of Airfoil Theory

DTIC Science & Technology

1944-08-01

TEE BASIS OF AIRFOIL THEORY By John T. Slnnette, Jr., Oscar W. Schey, and J. Austin King Aircraft Engine Research Laboratory Cleveland, Ohio FILE...efficiency can he designed by the proper application of airfoil theory. Aircraft Engine Research laboratory, Hational Advisory Committee for Aeronautlos...Basis of Airfoil Theory AUTHORS): Sinnette, John T.; Schey, Oscar W.; and others ORIGINATING AGENCY: Aircraft Engine Research Laboratory, Cleveland

Imaging Freeform Optical Systems Designed with NURBS Surfaces

DTIC Science & Technology

2015-12-01

reflective, anastigmat 1 Introduction The imaging freeform optical systems described here are designed using non-uniform rational basis -spline (NURBS...from piecewise splines. Figure 1 shows a third degree NURBS surface which is formed from cubic basis splines. The surface is defined by the set of...with mathematical details covered by Piegl and Tiller7. Compare this with Gaussian basis functions8 where it is challenging to provide smooth

Handbook of International alloy Compositions and Designations. Volume II. Superalloys

DTIC Science & Technology

1978-12-01

Offered in Italy 169 Table 12 . Typical Superalloys Offered in Japan 170 Table 13. Typical Superalloys Specified by Sweden 171 Table 14... 12 . Typical Superalloys Offered in Japan Table 13. Typical Superalloys Specified by Sweden Table 14. Typical Superalloys Offered in the Union of...Engineering Properties, INCO Europe Limited, London, England (1976), 12 pp. 8. IN-657 Cast-Nickel-Chromium-Niobium Alloy for Service Against Fuel + Ash

An Eye-Tracking Study of Multiple Feature Value Category Structure Learning: The Role of Unique Features

PubMed Central

Liu, Zhiya; Song, Xiaohong; Seger, Carol A.

2015-01-01

We examined whether the degree to which a feature is uniquely characteristic of a category can affect categorization above and beyond the typicality of the feature. We developed a multiple feature value category structure with different dimensions within which feature uniqueness and typicality could be manipulated independently. Using eye tracking, we found that the highest attentional weighting (operationalized as number of fixations, mean fixation time, and the first fixation of the trial) was given to a dimension that included a feature that was both unique and highly typical of the category. Dimensions that included features that were highly typical but not unique, or were unique but not highly typical, received less attention. A dimension with neither a unique nor a highly typical feature received least attention. On the basis of these results we hypothesized that subjects categorized via a rule learning procedure in which they performed an ordered evaluation of dimensions, beginning with unique and strongly typical dimensions, and in which earlier dimensions received higher weighting in the decision. This hypothesis accounted for performance on transfer stimuli better than simple implementations of two other common theories of category learning, exemplar models and prototype models, in which all dimensions were evaluated in parallel and received equal weighting. PMID:26274332

An Eye-Tracking Study of Multiple Feature Value Category Structure Learning: The Role of Unique Features.

PubMed

Liu, Zhiya; Song, Xiaohong; Seger, Carol A

2015-01-01

We examined whether the degree to which a feature is uniquely characteristic of a category can affect categorization above and beyond the typicality of the feature. We developed a multiple feature value category structure with different dimensions within which feature uniqueness and typicality could be manipulated independently. Using eye tracking, we found that the highest attentional weighting (operationalized as number of fixations, mean fixation time, and the first fixation of the trial) was given to a dimension that included a feature that was both unique and highly typical of the category. Dimensions that included features that were highly typical but not unique, or were unique but not highly typical, received less attention. A dimension with neither a unique nor a highly typical feature received least attention. On the basis of these results we hypothesized that subjects categorized via a rule learning procedure in which they performed an ordered evaluation of dimensions, beginning with unique and strongly typical dimensions, and in which earlier dimensions received higher weighting in the decision. This hypothesis accounted for performance on transfer stimuli better than simple implementations of two other common theories of category learning, exemplar models and prototype models, in which all dimensions were evaluated in parallel and received equal weighting.

Charter School Autonomy: A Half-Broken Promise

ERIC Educational Resources Information Center

Brinson, Dana; Rosch, Jacob

2010-01-01

For nearly two decades, charter founders have opened schools across the land on the basis of a distinctive education bargain: operational autonomy--freedom from restrictions typically placed on public schools--in exchange for strong results-based accountability. During that time, many have studied the "results" and "accountability" side of this…

Neuropsychological Evaluation in the Diagnosis and Treatment of Tourette's Syndrome

ERIC Educational Resources Information Center

Osmon, David C.; Smerz, Jessica M.

2005-01-01

The neurobiological basis of Tourettes syndrome is reviewed for the purpose of presenting a clinically relevant account of the neuropsychology of the disorder for the clinician who is behaviorally oriented. The neuropathology and neuropsychological deficits typically found in Tourettes are reviewed, and a neuropsychological test battery is…

Being Human: Transdisciplinarity in Nursing

ERIC Educational Resources Information Center

Timmons, Stephen; Edgley, Alison; Meal, Andy; Narayanasamy, Aru

2016-01-01

Nursing as an academic discipline typically draws on a wide range of other disciplines. There is debate about whether this is a sound basis for the discipline, or whether nursing needs to develop a distinctive body of knowledge. The concept of transdisciplinarity, though little discussed in nursing, is of considerable value in understanding…

Cultivar variation in silicon accumulation and distribution in Petunia ×hybrida

USDA-ARS?s Scientific Manuscript database

Silicon (Si) is a plant-beneficial element that can alleviate the effects of abiotic and biotic stress. Plants are typically classified as Si accumulators or non-accumulators based on foliar Si concentrations (= 1% Si on a dry weight basis for accumulators). Based on this definition, most greenhou...

Long-read sequencing improves assembly of Trichinella genomes 10-fold, revealing substantial synteny between lineages diverged over seven million years

USDA-ARS?s Scientific Manuscript database

Genome evolution influences a parasite’s’s pathogenicity, host-pathogen interactions, environmental constraints, and invasion biology, while genome assemblies form the basis of comparative sequence analyses. Given that closely related organisms typically maintain appreciable synteny, the genome asse...

A Systematic Evaulation of Analogs and Automated Read-across Prediction of Estrogenicity (BOSC)

EPA Science Inventory

Read-across is a data gap filling technique widely used within category and analog approaches whereby property information for a data-poor (target) chemical is predicted using one or more “similar” chemicals (source analogs). Source analogs are typically identified on the basis o...

Learning Disabilities: Best Practices for Professionals.

ERIC Educational Resources Information Center

Bender, William N., Ed.

This book is written to assist the reader in understanding current thinking in the field of learning disabilities (LD), as well as current practices in that field. Part I describes the characteristics typically associated with LD, and includes the following chapters: "Neurological Basis of Learning Disabilities" (Richard M. Marshall and George W.…

Emergent Technological Literacy: What Do Children Bring to School?

ERIC Educational Resources Information Center

Mawson, W. B.

2013-01-01

There has been very little research into children's technological practice in early childhood settings. This article describes four typical examples of the technological activity that occurs on a daily basis in New Zealand early childhood settings. It is suggested that children come to compulsory schooling with well-developed technological…

How to Generate Chaos at Home.

ERIC Educational Resources Information Center

Smith, Douglas

1992-01-01

Describes an electronic circuit that can function as a prototype for chaotic systems. Specific applied voltages produce chaotic signals that can be viewed with an oscilloscope or be made audible with a home stereo system. Provides directions for assembly with typical costs, mathematical basis of chaos theory, and experimental extensions. (JJK)

48 CFR 1552.216-78 - Award term incentive plan.

Code of Federal Regulations, 2011 CFR

2011-10-01

... NIHCPS is an interactive database located on the Internet which EPA uses to record contractor performance... evaluation of performance, and, together with Agency need and availability of funding, serves as the basis.... Typically, the performance standards and AQLs will be defined in the QASP] (End of clause) Alternate 1 (FEB...

Assessment and Grading in Physical Education

ERIC Educational Resources Information Center

Mohnsen, Bonnie

2006-01-01

This article discusses the basis for assessing and grading students in physical education. Although students should dress appropriately for physical education, be physically active during class time, and improve their fitness (e.g., mile-run time), these items are typically not included in the physical education content standards. The vast…

Red flags: correlates of impaired species recovery

Treesearch

Jeffrey A. Hutchings; Stuart H. M. Butchart; Ben Collen; Michael K. Schwartz; Robin S. Waples

2012-01-01

Conservation biology research exhibits a striking but unhelpful dichotomy. Analyses of species decline, extinction risk, and threat mitigation typically encompass broad taxonomic and spatial scales. By contrast, most studies of recovery lack generality, pertaining to specific species, populations, or locales. Narrowly focused analyses offer a weak empirical basis for...

Institutionalizing Faculty Mentoring within a Community of Practice Model

ERIC Educational Resources Information Center

Smith, Emily R.; Calderwood, Patricia E.; Storms, Stephanie Burrell; Lopez, Paula Gill; Colwell, Ryan P.

2016-01-01

In higher education, faculty work is typically enacted--and rewarded--on an individual basis. Efforts to promote collaboration run counter to the individual and competitive reward systems that characterize higher education. Mentoring initiatives that promote faculty collaboration and support also defy the structural and cultural norms of higher…

A Photonic Basis for Deriving Nonlinear Optical Response

ERIC Educational Resources Information Center

Andrews, David L.; Bradshaw, David S.

2009-01-01

Nonlinear optics is generally first presented as an extension of conventional optics. Typically the subject is introduced with reference to a classical oscillatory electric polarization, accommodating correction terms that become significant at high intensities. The material parameters that quantify the extent of the nonlinear response are cast as…

Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I.

PubMed Central

Takeshita, S; Kikuno, R; Tezuka, K; Amann, E

1993-01-01

A cDNA library prepared from the mouse osteoblastic cell line MC3T3-E1 was screened for the presence of specifically expressed genes by employing a combined subtraction hybridization/differential screening approach. A cDNA was identified and sequenced which encodes a protein designated osteoblast-specific factor 2 (OSF-2) comprising 811 amino acids. OSF-2 has a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain and a C-terminal domain. The protein lacks a typical transmembrane region. The fourfold repeated domain of OSF-2 shows homology with the insect protein fasciclin I. RNA analyses revealed that OSF-2 is expressed in bone and to a lesser extent in lung, but not in other tissues. Mouse OSF-2 cDNA was subsequently used as a probe to clone the human counterpart. Mouse and human OSF-2 show a high amino acid sequence conservation except for the signal sequence and two regions in the C-terminal domain in which 'in-frame' insertions or deletions are observed, implying alternative splicing events. On the basis of the amino acid sequence homology with fasciclin I, we suggest that OSF-2 functions as a homophilic adhesion molecule in bone formation. Images Figure 3 Figure 4 Figure 5 Figure 6 PMID:8363580

Like-Charge Guanidinium Pairing between Ligand and Receptor: An Unusual Interaction for Drug Discovery and Design?

PubMed

Yang, Yang; Xu, Zhijian; Zhang, Zhengyan; Yang, Zhuo; Liu, Yingtao; Wang, Jinan; Cai, Tingting; Li, Shujin; Chen, Kaixian; Shi, Jiye; Zhu, Weiliang

2015-09-10

A database survey in this study revealed for the first time that there are 227 counterintuitive like-charge guanidinium pairings (Gdm(+)-Arg pairings) between ligands and receptors in the Protein Data Bank, implying the potential guanidinium-arginine binding between guanidine-containing drugs and their target proteins. Furthermore, there are 145 guanidine-containing molecules in the DrugBank, showing the prevalence of guanidinium groups in drugs. It has also been reported that the introduction of a guanidinium group forming Gdm(+)-Arg pairing improved the potency of the drug by more than 8-fold in a typical case. On the basis of the survey, six ligand-protein complexes with typical Gdm(+)-Arg pairings were chosen for QM/MM calculations. The calculations at the B97-D/6-311++g(d,p) level revealed that the interaction could be as strong as -1.0 to -2.5 kcal/mol in DMSO and water, comparable to common intermolecular interactions. The calculations also unveiled that the Gdm(+)-Arg pairing interactions change from repulsive to attractive with the increase of dielectric constant, suggesting that the dielectric constant has a general stabilization effect on the Gdm(+)-Arg pairing. This study suggested that the like-charge guanidinium pairing interaction could be used not only for tuning the physical and chemical properties of drug leads but also for improving ligand binding affinity.

Development of non-destructive examination techniques for CFC-metal joints in annular geometry and their application to the manufacturing of plasma-facing components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Pietro, E.; Visca, E.; Orsini, A.

1995-12-31

The design of plasma-facing components for ITER, as for any of the envisaged next-step machines, relies heavily on the use of brazed junctions to couple armour materials to the heat sink and cooling tubes. Moreover, the typical number of brazed components and the envisaged effects of local overheating due to failure in a single brazed junction stress the importance of having a set of NDE techniques developed that can ensure the flawless quality of the joint. The qualification and application of two NDE techniques (ultrasonic and thermographic analysis) for inspection of CFC-to-metal joints is described with particular regard to themore » annular geometry typical of macroblock/monoblock solutions for divertor high-heat-flux components. The results of the eddy current inspection are not reported. The development has been focused specifically on the joint between carbon-fiber composite and TZM molybdenum alloy; techniques for the production of reference defect samples have been devised and a set of reference defect samples produced. The comparative results of the NDE inspections are reported and discussed, also on the basis of the destructive examination of the samples. The nature and size of relevant and detectable defects are discussed together with hints for a possible NDE strategy for divertor high-heat-flux components.« less

How to Make a Synthetic Multicellular Computer

PubMed Central

Macia, Javier; Sole, Ricard

2014-01-01

Biological systems perform computations at multiple scales and they do so in a robust way. Engineering metaphors have often been used in order to provide a rationale for modeling cellular and molecular computing networks and as the basis for their synthetic design. However, a major constraint in this mapping between electronic and wet computational circuits is the wiring problem. Although wires are identical within electronic devices, they must be different when using synthetic biology designs. Moreover, in most cases the designed molecular systems cannot be reused for other functions. A new approximation allows us to simplify the problem by using synthetic cellular consortia where the output of the computation is distributed over multiple engineered cells. By evolving circuits in silico, we can obtain the minimal sets of Boolean units required to solve the given problem at the lowest cost using cellular consortia. Our analysis reveals that the basic set of logic units is typically non-standard. Among the most common units, the so called inverted IMPLIES (N-Implies) appears to be one of the most important elements along with the NOT and AND functions. Although NOR and NAND gates are widely used in electronics, evolved circuits based on combinations of these gates are rare, thus suggesting that the strategy of combining the same basic logic gates might be inappropriate in order to easily implement synthetic computational constructs. The implications for future synthetic designs, the general view of synthetic biology as a standard engineering domain, as well as potencial drawbacks are outlined. PMID:24586222

Design-Load Basis for LANL Structures, Systems, and Components

DOE Office of Scientific and Technical Information (OSTI.GOV)

I. Cuesta

2004-09-01

This document supports the recommendations in the Los Alamos National Laboratory (LANL) Engineering Standard Manual (ESM), Chapter 5--Structural providing the basis for the loads, analysis procedures, and codes to be used in the ESM. It also provides the justification for eliminating the loads to be considered in design, and evidence that the design basis loads are appropriate and consistent with the graded approach required by the Department of Energy (DOE) Code of Federal Regulation Nuclear Safety Management, 10, Part 830. This document focuses on (1) the primary and secondary natural phenomena hazards listed in DOE-G-420.1-2, Appendix C, (2) additional loadsmore » not related to natural phenomena hazards, and (3) the design loads on structures during construction.« less

Identified research directions for using manufacturing knowledge earlier in the product lifecycle

PubMed Central

Hedberg, Thomas D.; Hartman, Nathan W.; Rosche, Phil; Fischer, Kevin

2016-01-01

Design for Manufacturing (DFM), especially the use of manufacturing knowledge to support design decisions, has received attention in the academic domain. However, industry practice has not been studied enough to provide solutions that are mature for industry. The current state of the art for DFM is often rule-based functionality within Computer-Aided Design (CAD) systems that enforce specific design requirements. That rule-based functionality may or may not dynamically affect geometry definition. And, if rule-based functionality exists in the CAD system, it is typically a customization on a case-by-case basis. Manufacturing knowledge is a phrase with vast meanings, which may include knowledge on the effects of material properties decisions, machine and process capabilities, or understanding the unintended consequences of design decisions on manufacturing. One of the DFM questions to answer is how can manufacturing knowledge, depending on its definition, be used earlier in the product lifecycle to enable a more collaborative development environment? This paper will discuss the results of a workshop on manufacturing knowledge that highlights several research questions needing more study. This paper proposes recommendations for investigating the relationship of manufacturing knowledge with shape, behavior, and context characteristics of product to produce a better understanding of what knowledge is most important. In addition, the proposal includes recommendations for investigating the system-level barriers to reusing manufacturing knowledge and how model-based manufacturing may ease the burden of knowledge sharing. Lastly, the proposal addresses the direction of future research for holistic solutions of using manufacturing knowledge earlier in the product lifecycle. PMID:27990027

Identified research directions for using manufacturing knowledge earlier in the product lifecycle.

PubMed

Hedberg, Thomas D; Hartman, Nathan W; Rosche, Phil; Fischer, Kevin

2017-01-01

Design for Manufacturing (DFM), especially the use of manufacturing knowledge to support design decisions, has received attention in the academic domain. However, industry practice has not been studied enough to provide solutions that are mature for industry. The current state of the art for DFM is often rule-based functionality within Computer-Aided Design (CAD) systems that enforce specific design requirements. That rule-based functionality may or may not dynamically affect geometry definition. And, if rule-based functionality exists in the CAD system, it is typically a customization on a case-by-case basis. Manufacturing knowledge is a phrase with vast meanings, which may include knowledge on the effects of material properties decisions, machine and process capabilities, or understanding the unintended consequences of design decisions on manufacturing. One of the DFM questions to answer is how can manufacturing knowledge, depending on its definition, be used earlier in the product lifecycle to enable a more collaborative development environment? This paper will discuss the results of a workshop on manufacturing knowledge that highlights several research questions needing more study. This paper proposes recommendations for investigating the relationship of manufacturing knowledge with shape, behavior, and context characteristics of product to produce a better understanding of what knowledge is most important. In addition, the proposal includes recommendations for investigating the system-level barriers to reusing manufacturing knowledge and how model-based manufacturing may ease the burden of knowledge sharing. Lastly, the proposal addresses the direction of future research for holistic solutions of using manufacturing knowledge earlier in the product lifecycle.

Fiber Orientation Estimation Guided by a Deep Network.

PubMed

Ye, Chuyang; Prince, Jerry L

2017-09-01

Diffusion magnetic resonance imaging (dMRI) is currently the only tool for noninvasively imaging the brain's white matter tracts. The fiber orientation (FO) is a key feature computed from dMRI for tract reconstruction. Because the number of FOs in a voxel is usually small, dictionary-based sparse reconstruction has been used to estimate FOs. However, accurate estimation of complex FO configurations in the presence of noise can still be challenging. In this work we explore the use of a deep network for FO estimation in a dictionary-based framework and propose an algorithm named Fiber Orientation Reconstruction guided by a Deep Network (FORDN). FORDN consists of two steps. First, we use a smaller dictionary encoding coarse basis FOs to represent diffusion signals. To estimate the mixture fractions of the dictionary atoms, a deep network is designed to solve the sparse reconstruction problem. Second, the coarse FOs inform the final FO estimation, where a larger dictionary encoding a dense basis of FOs is used and a weighted ℓ 1 -norm regularized least squares problem is solved to encourage FOs that are consistent with the network output. FORDN was evaluated and compared with state-of-the-art algorithms that estimate FOs using sparse reconstruction on simulated and typical clinical dMRI data. The results demonstrate the benefit of using a deep network for FO estimation.

75 FR 11574 - Draft Regulatory Guide: Issuance, Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... agency's ``Regulatory Guide'' series. This series was developed to describe and make available to the... protection during plant operation and maintenance activities. For plants that have a design basis that... coatings be qualified and capable of surviving a design-basis accident without adversely affecting safety...

75 FR 53352 - Draft Regulatory Guide: Issuance, Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... Guide, DG-1247, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants.'' FOR FURTHER...'s ``Regulatory Guide'' series. This series was developed to describe and make available to the.... The draft regulatory guide (DG), entitled, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear...

Using Automated Essay Scores as an Anchor When Equating Constructed Response Writing Tests

ERIC Educational Resources Information Center

Almond, Russell G.

2014-01-01

Assessments consisting of only a few extended constructed response items (essays) are not typically equated using anchor test designs as there are typically too few essay prompts in each form to allow for meaningful equating. This article explores the idea that output from an automated scoring program designed to measure writing fluency (a common…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swamy, S.A.; Bhowmick, D.C.; Prager, D.E.

The regulatory requirements for postulated pipe ruptures have changed significantly since the first nuclear plants were designed. The Leak-Before-Break (LBB) methodology is now accepted as a technically justifiable approach for eliminating postulation of double-ended guillotine breaks (DEGB) in high energy piping systems. The previous pipe rupture design requirements for nuclear power plant applications are responsible for all the numerous and massive pipe whip restraints and jet shields installed for each plant. This results in significant plant congestion, increased labor costs and radiation dosage for normal maintenance and inspection. Also the restraints increase the probability of interference between the piping andmore » supporting structures during plant heatup, thereby potentially impacting overall plant reliability. The LBB approach to eliminate postulating ruptures in high energy piping systems is a significant improvement to former regulatory methodologies, and therefore, the LBB approach to design is gaining worldwide acceptance. However, the methods and criteria for LBB evaluation depend upon the policy of individual country and significant effort continues towards accomplishing uniformity on a global basis. In this paper the historical development of the U.S. LBB criteria will be traced and the results of an LBB evaluation for a typical Japanese PWR primary loop applying U.S. NRC approved methods will be presented. In addition, another approach using the Japanese LBB criteria will be shown and compared with the U.S. criteria. The comparison will be highlighted in this paper with detailed discussion.« less

Learning a novel phonological contrast depends on interactions between individual differences and training paradigm design.

PubMed

Perrachione, Tyler K; Lee, Jiyeon; Ha, Louisa Y Y; Wong, Patrick C M

2011-07-01

Studies evaluating phonological contrast learning typically investigate either the predictiveness of specific pretraining aptitude measures or the efficacy of different instructional paradigms. However, little research considers how these factors interact--whether different students learn better from different types of instruction--and what the psychological basis for any interaction might be. The present study demonstrates that successfully learning a foreign-language phonological contrast for pitch depends on an interaction between individual differences in perceptual abilities and the design of the training paradigm. Training from stimuli with high acoustic-phonetic variability is generally thought to improve learning; however, we found high-variability training enhanced learning only for individuals with strong perceptual abilities. Learners with weaker perceptual abilities were actually impaired by high-variability training relative to a low-variability condition. A second experiment assessing variations on the high-variability training design determined that the property of this learning environment most detrimental to perceptually weak learners is the amount of trial-by-trial variability. Learners' perceptual limitations can thus override the benefits of high-variability training where trial-by-trial variability in other irrelevant acoustic-phonetic features obfuscates access to the target feature. These results demonstrate the importance of considering individual differences in pretraining aptitudes when evaluating the efficacy of any speech training paradigm. © 2011 Acoustical Society of America

Remote systems development

NASA Technical Reports Server (NTRS)

Olsen, R.; Schaefer, O.; Hussey, J.

1992-01-01

Potential space missions of the nineties and the next century require that we look at the broad category of remote systems as an important means to achieve cost-effective operations, exploration and colonization objectives. This paper addresses such missions, which can use remote systems technology as the basis for identifying required capabilities which must be provided. The relationship of the space-based tasks to similar tasks required for terrestrial applications is discussed. The development status of the required technology is assessed and major issues which must be addressed to meet future requirements are identified. This includes the proper mix of humans and machines, from pure teleoperation to full autonomy; the degree of worksite compatibility for a robotic system; and the required design parameters, such as degrees-of-freedom. Methods for resolution are discussed including analysis, graphical simulation and the use of laboratory test beds. Grumman experience in the application of these techniques to a variety of design issues are presented utilizing the Telerobotics Development Laboratory which includes a 17-DOF robot system, a variety of sensing elements, Deneb/IRIS graphics workstations and control stations. The use of task/worksite mockups, remote system development test beds and graphical analysis are discussed with examples of typical results such as estimates of task times, task feasibility and resulting recommendations for design changes. The relationship of this experience and lessons-learned to future development of remote systems is also discussed.

Summary and recommendations for initial exercise prescription

NASA Technical Reports Server (NTRS)

Stewart, Donald F.; Harris, Bernard A., Jr.

1989-01-01

The recommendations summarized herein constitute a basis on which an initial exercise prescription can be formulated. It is noteworthy that any exercise program designed currently would be an approximation. Examination of the existing space-flight data reveals a scarcity of in-flight data on which to rigorously design an exercise program. The relevant experience within the U.S. space program (with regard to long-duration space flight) is limited to the Skylab Program. Lessons learned from Skylab are relevant to the design of a Space Station exercise program, especially with regard to the total length of exercise time required, cardiovascular (CV) deconditioning/reconditioning, and bone loss. Certain observations of the U.S.S.R. exercise activities can also contribute to the formulation of an exercise prescription of Space Station. Reportedly, the U.S.S.R. uses both a bicycle ergometer and a treadmill device on long-duration missions with some degree of success. Using the third crew of Salyut 6, which was a 175-day stay, as a representative mission, the typical time dedicated to exercise varies from 2 to 3 hours per day. In addition, the cosmonauts wear an elasticized suit, called a penquin suit, for time periods ranging from 12 to 16 hours per day. This device provides a load across the axial skeleton against which the wearer must exert himself. Despite these extensive countermeasures, the effects of adaptation are not totally prevented.

Optimal Space Station solar array gimbal angle determination via radial basis function neural networks

NASA Technical Reports Server (NTRS)

Clancy, Daniel J.; Oezguener, Uemit; Graham, Ronald E.

1994-01-01

The potential for excessive plume impingement loads on Space Station Freedom solar arrays, caused by jet firings from an approaching Space Shuttle, is addressed. An artificial neural network is designed to determine commanded solar array beta gimbal angle for minimum plume loads. The commanded angle would be determined dynamically. The network design proposed involves radial basis functions as activation functions. Design, development, and simulation of this network design are discussed.

The Influence of Education and Experience Upon Contextual and Task Performance in Warehouse Operations

DTIC Science & Technology

2016-09-01

leadership. Subjects were randomly assigned to one of four groups to conduct a mixed- design experiment; the design included a 2 x 2 factorial component...The experimental design should have resulted in baseline groups that were representative of the target population; therefore, one would expect...1983; Sheridan, 2015). “SRK provides a language in which to talk about types of behavior as a basis for system design . It provides a basis on which

[Classification of Children with Attention-Deficit/Hyperactivity Disorder and Typically Developing Children Based on Electroencephalogram Principal Component Analysis and k-Nearest Neighbor].

PubMed

Yang, Jiaojiao; Guo, Qian; Li, Wenjie; Wang, Suhong; Zou, Ling

2016-04-01

This paper aims to assist the individual clinical diagnosis of children with attention-deficit/hyperactivity disorder using electroencephalogram signal detection method.Firstly,in our experiments,we obtained and studied the electroencephalogram signals from fourteen attention-deficit/hyperactivity disorder children and sixteen typically developing children during the classic interference control task of Simon-spatial Stroop,and we completed electroencephalogram data preprocessing including filtering,segmentation,removal of artifacts and so on.Secondly,we selected the subset electroencephalogram electrodes using principal component analysis(PCA)method,and we collected the common channels of the optimal electrodes which occurrence rates were more than 90%in each kind of stimulation.We then extracted the latency(200~450ms)mean amplitude features of the common electrodes.Finally,we used the k-nearest neighbor(KNN)classifier based on Euclidean distance and the support vector machine(SVM)classifier based on radial basis kernel function to classify.From the experiment,at the same kind of interference control task,the attention-deficit/hyperactivity disorder children showed lower correct response rates and longer reaction time.The N2 emerged in prefrontal cortex while P2 presented in the inferior parietal area when all kinds of stimuli demonstrated.Meanwhile,the children with attention-deficit/hyperactivity disorder exhibited markedly reduced N2 and P2amplitude compared to typically developing children.KNN resulted in better classification accuracy than SVM classifier,and the best classification rate was 89.29%in StI task.The results showed that the electroencephalogram signals were different in the brain regions of prefrontal cortex and inferior parietal cortex between attention-deficit/hyperactivity disorder and typically developing children during the interference control task,which provided a scientific basis for the clinical diagnosis of attention-deficit/hyperactivity disorder individuals.

An Approach for Assessing Consequences of Potential Supply Chain and Insider Contributed Cyber Attacks on Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu, Tsong-Lun; Varuttamaseni, Athi; Baek, Joo-Seok

This paper provides an approach for developing potential attacks on I and C systems of NPPs and assessing their consequences. An important concept is that the NPPs were not designed to cope with Stuxnet-type of attacks (and any other cyber attacks). That is, the plants were only designed for design basis accidents. The safety margins and redundancies built in the design are all based on design basis accidents. They may be helpful in mitigating cyberattacks, but may not be adequate.

Interactive computer graphics and its role in control system design of large space structures

NASA Technical Reports Server (NTRS)

Reddy, A. S. S. R.

1985-01-01

This paper attempts to show the relevance of interactive computer graphics in the design of control systems to maintain attitude and shape of large space structures to accomplish the required mission objectives. The typical phases of control system design, starting from the physical model such as modeling the dynamics, modal analysis, and control system design methodology are reviewed and the need of the interactive computer graphics is demonstrated. Typical constituent parts of large space structures such as free-free beams and free-free plates are used to demonstrate the complexity of the control system design and the effectiveness of the interactive computer graphics.

Integrating end-to-end threads of control into object-oriented analysis and design

NASA Technical Reports Server (NTRS)

Mccandlish, Janet E.; Macdonald, James R.; Graves, Sara J.

1993-01-01

Current object-oriented analysis and design methodologies fall short in their use of mechanisms for identifying threads of control for the system being developed. The scenarios which typically describe a system are more global than looking at the individual objects and representing their behavior. Unlike conventional methodologies that use data flow and process-dependency diagrams, object-oriented methodologies do not provide a model for representing these global threads end-to-end. Tracing through threads of control is key to ensuring that a system is complete and timing constraints are addressed. The existence of multiple threads of control in a system necessitates a partitioning of the system into processes. This paper describes the application and representation of end-to-end threads of control to the object-oriented analysis and design process using object-oriented constructs. The issue of representation is viewed as a grouping problem, that is, how to group classes/objects at a higher level of abstraction so that the system may be viewed as a whole with both classes/objects and their associated dynamic behavior. Existing object-oriented development methodology techniques are extended by adding design-level constructs termed logical composite classes and process composite classes. Logical composite classes are design-level classes which group classes/objects both logically and by thread of control information. Process composite classes further refine the logical composite class groupings by using process partitioning criteria to produce optimum concurrent execution results. The goal of these design-level constructs is to ultimately provide the basis for a mechanism that can support the creation of process composite classes in an automated way. Using an automated mechanism makes it easier to partition a system into concurrently executing elements that can be run in parallel on multiple processors.

CUMULATIVE EFFECTS OF IN UTERO ADMINISTRATION OF MIXTURES OF "ANTIANDROGENS" ON MALE RAT REPRODUCTIVIE DEVELOPMENT.

EPA Science Inventory

Although risk assessments are typically conducted on a chemical-bychemical

basis, the 1996 Food Quality Protection Act Law requires the USEPA to

consider cumulative risk of chemicals that act via a common mode/mechanism of

action. To this end, we are conducti...

Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development

EPA Science Inventory

Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act requires the USEPA to consider cumulative risk of chemicals that act via a common mechanism of toxicity. To this end, we are conducting studies to provide a fra...

Getting Stuck, Becoming Unstuck: Agency, Identity and Transitions between Learning Contexts

ERIC Educational Resources Information Center

Field, John; Lynch, Heather

2015-01-01

Flexibility and change are typically viewed as endemic features of late modernity, leading to increased emphasis on the importance of transition during the adult life course. The paper examines experiences of transition for eight contributors to a research project that collected and analysed life histories as the basis for an understanding of…

Discovering Structure in Auditory Input: Evidence from Williams Syndrome

ERIC Educational Resources Information Center

Elsabbagh, Mayada; Cohen, Henri; Karmiloff-Smith, Annette

2010-01-01

We examined auditory perception in Williams syndrome by investigating strategies used in organizing sound patterns into coherent units. In Experiment 1, we investigated the streaming of sound sequences into perceptual units, on the basis of pitch cues, in a group of children and adults with Williams syndrome compared to typical controls. We showed…

CUMULATIVE EFFECTS OF IN UTERO ADMINISTRATION OF A MIXTURE OF SEVEN ANTIANDROGENS ON MALE RAT REPRODUCTIVE DEVELOPMENT

EPA Science Inventory

Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 FQPA requires the USEPA to consider cumulative risk from chemicals that act via a common mechanism of action. To this end, we are conducting studies with mixtures to provide a framework fo...

Promoting Positive Social Behavior in Physical Education

ERIC Educational Resources Information Center

Balderson, Daniel; Sharpe, Tom

2004-01-01

An ongoing challenge that both classroom and physical education teachers face on a daily basis is how to organize and manage large groups of students. This is particularly true in many urban settings where classrooms and gymnasiums are typically understaffed and/or under equipped. Educators in these settings often struggle with how to minimize…

Sensory Sensitivities and Performance on Sensory Perceptual Tasks in High-Functioning Individuals with Autism

ERIC Educational Resources Information Center

Minshew, Nancy J.; Hobson, Jessica A.

2008-01-01

Most reports of sensory symptoms in autism are second hand or observational, and there is little evidence of a neurological basis. Sixty individuals with high-functioning autism and 61 matched typical participants were administered a sensory questionnaire and neuropsychological tests of elementary and higher cortical sensory perception. Thirty-two…

78 FR 10222 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... purchase or sell securities on a when-issued, delayed-delivery, or forward-commitment basis and may engage... (typically purchase price plus accrued interest). \\13\\ Reverse repurchase agreements involve the sale of... and have the characteristics of borrowing. The securities purchased with the funds obtained from the...

Cumulative Effects of in Uetro Administration of Mixtures of "Antiandrogens" on Male Rat Reproductive Development

EPA Science Inventory

Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 FQPA required the EPA to consider cumulative risk of chemicals that act via a common mechanism of toxicity. To this end, we are conducting studies with mixtures to provide a framework for ...

IN UTERO EXPOSURE TO AN AR ANTAGONIST PLUS AN INHIBITOR OF FETAL TESTOSTERONE SYNTHESIS INDUCESCUMULATIVE EFFECTS ON F1 MALE RATS

EPA Science Inventory

Risk assessments are typically conducted on a chemical-by-chemical basis; however, many regulatory bodies are developing frameworks for assessing the cumulative risk of chemical mixtures of chemicals. The current investigation examined how chemicals that disrupt rat sex different...

Characteristics of patients with symbrachydactyly.

PubMed

De Smet, L; Fabry, G

1998-04-01

The clinical and radiologic spectrum of symbrachydactyly has been extended, on the basis of experimental embryology, into four categories: typical symbrachydactyly, atypical cleft hand, monodactyly, and adactyly. The origin of this embryologic failure is probably a vascular disruption. A series of 64 hands and 3 feet are reported, indicating associated anomalies and possible etiologic features.

A Randomized Trial of Contingency Management Delivered in the Context of Group Counseling

ERIC Educational Resources Information Center

Petry, Nancy M.; Weinstock, Jeremiah; Alessi, Sheila M.

2011-01-01

Objective: Contingency management (CM) is efficacious in reducing drug use. Typically, reinforcers are provided on an individual basis to patients for submitting drug-negative samples. However, most treatment is provided in a group context, and poor attendance is a substantial concern. This study evaluated whether adding CM to group-based…

Ungulate ecology of ponderosa pine ecosystems in the northwest

Treesearch

Martin Vavra; Kenric Walburger; Timothy DelCurto

2005-01-01

Ponderosa pine ecosystems provide important foraging habitats for both wild and domestic ungulates. Livestock typically graze ponderosa pine ecosystems from May through October. Mule deer and elk may utilize these habitats on a yearlong basis in some areas. Stand density has a significant effect on understory production. Competition for soil moisture and nitrogen limit...

An assessment of the differences between spatial resolution and grid size for the SMAP enhanced soil moisture product over homogeneous sites

USDA-ARS?s Scientific Manuscript database

Satellite-based passive microwave remote sensing typically involves a scanning antenna that makes measurements at irregularly spaced locations. These locations can change on a day to day basis. Soil moisture products derived from satellite-based passive microwave remote sensing are usually resampled...

Building scientific confidence in metabolic similarity in read-across through the use of in vitro, in silico and analytical data

EPA Science Inventory

The underlying principle of read-across is that the biological activity of a chemical is inherent in its molecular structure. Analogues are typically identified by structural similarity then evaluated on the basis of their bioavailability, reactivity and metabolic similarity. Whi...

20180312 - Building scientific confidence in metabolic similarity in read-across through the use of in vitro, in silico and analytical data (SOT)

EPA Science Inventory

The underlying principle of read-across is that the biological activity of a chemical is inherent in its molecular structure. Analogues are typically identified by structural similarity then evaluated on the basis of their bioavailability, reactivity and metabolic similarity. Whi...

Maximum Likelihood Estimation in Meta-Analytic Structural Equation Modeling

ERIC Educational Resources Information Center

Oort, Frans J.; Jak, Suzanne

2016-01-01

Meta-analytic structural equation modeling (MASEM) involves fitting models to a common population correlation matrix that is estimated on the basis of correlation coefficients that are reported by a number of independent studies. MASEM typically consist of two stages. The method that has been found to perform best in terms of statistical…

Air-water Gas Exchange Rates on a Large Impounded River Measured Using Floating Domes (Poster)

EPA Science Inventory

Mass balance models of dissolved gases in rivers typically serve as the basis for whole-system estimates of greenhouse gas emission rates. An important component of these models is the exchange of dissolved gases between air and water. Controls on gas exchange rates (K) have be...

Genetics of dispersal.

PubMed

Saastamoinen, Marjo; Bocedi, Greta; Cote, Julien; Legrand, Delphine; Guillaume, Frédéric; Wheat, Christopher W; Fronhofer, Emanuel A; Garcia, Cristina; Henry, Roslyn; Husby, Arild; Baguette, Michel; Bonte, Dries; Coulon, Aurélie; Kokko, Hanna; Matthysen, Erik; Niitepõld, Kristjan; Nonaka, Etsuko; Stevens, Virginie M; Travis, Justin M J; Donohue, Kathleen; Bullock, James M; Del Mar Delgado, Maria

2018-02-01

Dispersal is a process of central importance for the ecological and evolutionary dynamics of populations and communities, because of its diverse consequences for gene flow and demography. It is subject to evolutionary change, which begs the question, what is the genetic basis of this potentially complex trait? To address this question, we (i) review the empirical literature on the genetic basis of dispersal, (ii) explore how theoretical investigations of the evolution of dispersal have represented the genetics of dispersal, and (iii) discuss how the genetic basis of dispersal influences theoretical predictions of the evolution of dispersal and potential consequences. Dispersal has a detectable genetic basis in many organisms, from bacteria to plants and animals. Generally, there is evidence for significant genetic variation for dispersal or dispersal-related phenotypes or evidence for the micro-evolution of dispersal in natural populations. Dispersal is typically the outcome of several interacting traits, and this complexity is reflected in its genetic architecture: while some genes of moderate to large effect can influence certain aspects of dispersal, dispersal traits are typically polygenic. Correlations among dispersal traits as well as between dispersal traits and other traits under selection are common, and the genetic basis of dispersal can be highly environment-dependent. By contrast, models have historically considered a highly simplified genetic architecture of dispersal. It is only recently that models have started to consider multiple loci influencing dispersal, as well as non-additive effects such as dominance and epistasis, showing that the genetic basis of dispersal can influence evolutionary rates and outcomes, especially under non-equilibrium conditions. For example, the number of loci controlling dispersal can influence projected rates of dispersal evolution during range shifts and corresponding demographic impacts. Incorporating more realism in the genetic architecture of dispersal is thus necessary to enable models to move beyond the purely theoretical towards making more useful predictions of evolutionary and ecological dynamics under current and future environmental conditions. To inform these advances, empirical studies need to answer outstanding questions concerning whether specific genes underlie dispersal variation, the genetic architecture of context-dependent dispersal phenotypes and behaviours, and correlations among dispersal and other traits. © 2017 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.

Genetics of dispersal

PubMed Central

Bocedi, Greta; Cote, Julien; Legrand, Delphine; Guillaume, Frédéric; Wheat, Christopher W.; Fronhofer, Emanuel A.; Garcia, Cristina; Henry, Roslyn; Husby, Arild; Baguette, Michel; Bonte, Dries; Coulon, Aurélie; Kokko, Hanna; Matthysen, Erik; Niitepõld, Kristjan; Nonaka, Etsuko; Stevens, Virginie M.; Travis, Justin M. J.; Donohue, Kathleen; Bullock, James M.; del Mar Delgado, Maria

2017-01-01

ABSTRACT Dispersal is a process of central importance for the ecological and evolutionary dynamics of populations and communities, because of its diverse consequences for gene flow and demography. It is subject to evolutionary change, which begs the question, what is the genetic basis of this potentially complex trait? To address this question, we (i) review the empirical literature on the genetic basis of dispersal, (ii) explore how theoretical investigations of the evolution of dispersal have represented the genetics of dispersal, and (iii) discuss how the genetic basis of dispersal influences theoretical predictions of the evolution of dispersal and potential consequences. Dispersal has a detectable genetic basis in many organisms, from bacteria to plants and animals. Generally, there is evidence for significant genetic variation for dispersal or dispersal‐related phenotypes or evidence for the micro‐evolution of dispersal in natural populations. Dispersal is typically the outcome of several interacting traits, and this complexity is reflected in its genetic architecture: while some genes of moderate to large effect can influence certain aspects of dispersal, dispersal traits are typically polygenic. Correlations among dispersal traits as well as between dispersal traits and other traits under selection are common, and the genetic basis of dispersal can be highly environment‐dependent. By contrast, models have historically considered a highly simplified genetic architecture of dispersal. It is only recently that models have started to consider multiple loci influencing dispersal, as well as non‐additive effects such as dominance and epistasis, showing that the genetic basis of dispersal can influence evolutionary rates and outcomes, especially under non‐equilibrium conditions. For example, the number of loci controlling dispersal can influence projected rates of dispersal evolution during range shifts and corresponding demographic impacts. Incorporating more realism in the genetic architecture of dispersal is thus necessary to enable models to move beyond the purely theoretical towards making more useful predictions of evolutionary and ecological dynamics under current and future environmental conditions. To inform these advances, empirical studies need to answer outstanding questions concerning whether specific genes underlie dispersal variation, the genetic architecture of context‐dependent dispersal phenotypes and behaviours, and correlations among dispersal and other traits. PMID:28776950

Teaching Sustainable Water Resources and Low Impact Development: A Project Centered Course for First-Year Undergraduates

NASA Astrophysics Data System (ADS)

Cianfrani, C. M.

2009-12-01

Teaching Sustainable Water Resources and Low Impact Development: A Project Centered Course for First-Year Undergraduates Christina M. Cianfrani Assistant Professor, School of Natural Science, Hampshire College, 893 West Avenue, Amherst, MA 01002 Sustainable water resources and low impact development principles are taught to first-year undergraduate students using an applied design project sited on campus. All students at Hampshire College are required to take at least one natural science course during their first year as part of their liberal arts education. This requirement is often met with resistance from non-science students. However, ‘sustainability’ has shown to be a popular topic on campus and ‘Sustainable Water Resources’ typically attracts ~25 students (a large class size for Hampshire College). Five second- or third-year students are accepted in the class as advanced students and serve as project leaders. The first-year students often enter the class with only basic high school science background. The class begins with an introduction to global water resources issues to provide a broad perspective. The students then analyze water budgets, both on a watershed basis and a personal daily-use basis. The students form groups of 4 to complete their semester project. Lectures on low impact design principles are combined with group work sessions for the second half of the semester. Students tour the physical site located across the street from campus and begin their project with a site analysis including soils, landcover and topography. They then develop a building plan and identify preventative and mitigative measures for dealing with stormwater. Each group completes TR-55 stormwater calculations for their design (pre- and post-development) to show the state regulations for quantity will be met with their design. Finally, they present their projects to the class and prepare a formal written report. The students have produced a wide variety of creative, mostly practical designs. Student feedback about the course has included high praise for the applied nature of the project as well as the use of advanced students to lead the groups and help provide guidance throughout the project. Example of low impact development using clustered housing, rain gardens (small dots), green roofs (circles on house sites), vegetated swales along roadways, infiltration area, and a reforested buffer (along right edge).

Effects of Stress Typicality during Speeded Grammatical Classification

ERIC Educational Resources Information Center

Arciuli, Joanne; Cupples, Linda

2003-01-01

The experiments reported here were designed to investigate the influence of stress typicality during speeded grammatical classification of disyllabic English words by native and non-native speakers. Trochaic nouns and iambic verbs were considered to be typically stressed, whereas iambic nouns and trochaic verbs were considered to be atypically…

10 CFR Appendix C to Part 73 - Nuclear Power Plant Safeguards Contingency Plans

Code of Federal Regulations, 2013 CFR

2013-01-01

... command and delegation of authority as these apply to safeguards contingencies. b. Physical Layout—(i..., up to and including the design basis threat of radiological sabotage. The goals of licensee... general description of how the response is organized. a. Perceived Danger—Consistent with the design basis...

14 CFR 121.162 - ETOPS Type Design Approval Basis.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false ETOPS Type Design Approval Basis. 121.162 Section 121.162 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL...

The impact of hydrogen on the formability of AHSS in Nakajima tests

NASA Astrophysics Data System (ADS)

Gao, Qi; Han, Fei; Wortberg, Daniel; Bleck, Wolfgang; Liewald, Mathias

2016-10-01

The application of Advanced High Strength Steels (AHSS) in the design of automotive body-in-white structures meets the requirement of light weight construction. The susceptibility to Hydrogen Embrittlement however, limits the wide application of steel grades over 1000 MPa. Up to now, various published studies focused on the hydrogen effects on mechanical properties; the impact of hydrogen on formability was not clarified. The present work aims to evaluate the influence of hydrogen on forming limit and fracture behavior in different strain states during the forming process. The hydrogen concentration in the material was modified by cathodic electro-charging. Nakajima tests in three strain conditions on uncharged and pre-charged samples were carried out. The localized necking was determined on the basis of the representative thinning rate in necking areas. The results revealed the shift of forming limits and critical strains to fracture owing to the presence of massive hydrogen. The fractography by Scanning Electron Microscope gave evidence of typical hydrogen-induced cleavage fracture on pre-charged samples.

Experimental validation and model development for thermal transmittances of porous window screens and horizontal louvred blind systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, Robert; Goudey, Howdy; Curcija, D. Charlie

Virtually every home in the US has some form of shades, blinds, drapes, or other window attachment, but few have been designed for energy savings. In order to provide a common basis of comparison for thermal performance it is important to have validated simulation tools. This study outlines a review and validation of the ISO 15099 centre-of-glass thermal transmittance correlations for naturally ventilated cavities through measurement and detailed simulations. The focus is on the impacts of room-side ventilated cavities, such as those found with solar screens and horizontal louvred blinds. The thermal transmittance of these systems is measured experimentally, simulatedmore » using computational fluid dynamics analysis, and simulated utilizing simplified correlations from ISO 15099. Finally, correlation coefficients are proposed for the ISO 15099 algorithm that reduces the mean error between measured and simulated heat flux for typical solar screens from 16% to 3.5% and from 13% to 1% for horizontal blinds.« less

Targeting overall equipment efficiency for small medium enterprises with irregular production system

NASA Astrophysics Data System (ADS)

Prasetyawan, Y.; Suef, M.; Claudia, L.; Handayani, F. D.

2018-04-01

Overall Equipment Effectiveness (OEE) is widely used to measure the maturity of a production system. The company will be considered as World Class Manufacturing if it reaches more than 85% value, with near perfect value for availability, performance and quality factor. This assessment is usually taken on industries with regular production times named shift system. A typical 8 hours shift system is used in OEE measurement and performance monitoring. There are few Small to Medium Enterprise (SME) perform regular production times with shift systems, others using irregular production systems. The irregular production time in the SME production system is used because of demand fluctuations. This paper shows a quantitative analysis as a part of manufacturing system design to achieve a specific value of OEE for SME with irregular production systems, for individual businesses as well as collective business systems (some companies use the same production facilities for several processes). The results of experiments on several companies are presented, as a basis for determining the technical strategy of achieving OEE values.

Nondestructive Examination for Nuclear Power Plant Cable Aging Management Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glass, Samuel W.; Fifield, Leonard S.

2016-01-01

Degradation of the cable jacket, electrical insulation, and other cable components of installed cables within nuclear power plants (NPPs) is known to occur as a function of age, temperature, radiation, and other environmental factors. System tests verify cable function under normal loads; however, the concern is over cable performance under exceptional loads associated with design-basis events (DBEs). The cable’s ability to perform safely over the initial 40 year planned and licensed life has generally been demonstrated and there have been very few age-related cable failures. With greater than 1000 km of power, control, instrumentation, and other cables typically found inmore » an NPP, replacing all the cables would be a severe cost burden. Justification for life extension to 60 and 80 years requires a cable aging management program (AMP) to justify cable performance under normal operation as well as accident conditions. This paper addresses various NDE technologies that constitute the essence of an acceptable aging management program.« less

Design, Simulation and Fabrication of Triaxial MEMS High Shock Accelerometer.

PubMed

Zhang, Zhenhai; Shi, Zhiguo; Yang, Zhan; Xie, Zhihong; Zhang, Donghong; Cai, De; Li, Kejie; Shen, Yajing

2015-04-01

On the basis of analyzing the disadvantage of other structural accelerometer, three-axis high g MEMS piezoresistive accelerometer was put forward in order to apply to the high-shock test field. The accelerometer's structure and working principle were discussed in details. The simulation results show that three-axis high shock MEMS accelerometer can bear high shock. After bearing high shock impact in high-shock shooting test, three-axis high shock MEMS accelerometer can obtain the intact metrical information of the penetration process and still guarantee the accurate precision of measurement in high shock load range, so we can not only analyze the law of stress wave spreading and the penetration rule of the penetration process of the body of the missile, but also furnish the testing technology of the burst point controlling. The accelerometer has far-ranging application in recording the typical data that projectile penetrating hard target and furnish both technology guarantees for penetration rule and defend engineering.

How pleasant sounds promote and annoying sounds impede health: a cognitive approach.

PubMed

Andringa, Tjeerd C; Lanser, J Jolie L

2013-04-08

This theoretical paper addresses the cognitive functions via which quiet and in general pleasurable sounds promote and annoying sounds impede health. The article comprises a literature analysis and an interpretation of how the bidirectional influence of appraising the environment and the feelings of the perceiver can be understood in terms of core affect and motivation. This conceptual basis allows the formulation of a detailed cognitive model describing how sonic content, related to indicators of safety and danger, either allows full freedom over mind-states or forces the activation of a vigilance function with associated arousal. The model leads to a number of detailed predictions that can be used to provide existing soundscape approaches with a solid cognitive science foundation that may lead to novel approaches to soundscape design. These will take into account that louder sounds typically contribute to distal situational awareness while subtle environmental sounds provide proximal situational awareness. The role of safety indicators, mediated by proximal situational awareness and subtle sounds, should become more important in future soundscape research.

[Health management as part of leadership in public administration].

PubMed

Matyssek, A K

2012-02-01

Leadership includes two tasks within public administration: leading employees by creating healthy working conditions and being led by others. The basis of leading others in a healthy way means dealing with oneself in a healthy manner; this includes typical healthy behavior (i.e., physical activity, improved nutrition, not smoking), which allows for recovery by a good work-life balance and a sensitive dealing with one's own limits. Given these conditions of healthy self care, managers are able to act as role models and lead their employees in a healthy manner. Leading in a healthy manner means showing appreciation, being interested in the employees ("caring"), integrating them in decision-making, allowing transparency, improving the working atmosphere, and finally reducing stress and increasing resources. The latter includes social support, which decreases the danger of employees burning out. The article presents the concept of a 2-day training that is designed for managers in order to raise their awareness for duties related to health management in public administration.

Investigation of the impact of main control room digitalization on operators cognitive reliability in nuclear power plants.

PubMed

Zhou, Yong; Mu, Haiying; Jiang, Jianjun; Zhang, Li

2012-01-01

Currently, there is a trend in nuclear power plants (NPPs) toward introducing digital and computer technologies into main control rooms (MCRs). Safe generation of electric power in NPPs requires reliable performance of cognitive tasks such as fault detection, diagnosis, and response planning. The digitalization of MCRs has dramatically changed the whole operating environment, and the ways operators interact with the plant systems. If the design and implementation of the digital technology is incompatible with operators' cognitive characteristics, it may have negative effects on operators' cognitive reliability. Firstly, on the basis of three essential prerequisites for successful cognitive tasks, a causal model is constructed to reveal the typical human performance issues arising from digitalization. The cognitive mechanisms which they impact cognitive reliability are analyzed in detail. Then, Bayesian inference is used to quantify and prioritize the influences of these factors. It suggests that interface management and unbalanced workload distribution have more significant impacts on operators' cognitive reliability.

Study on performance and flow field of an undershot cross-flow water turbine comprising different number of blades

NASA Astrophysics Data System (ADS)

Nishi, Yasuyuki; Hatano, Kentaro; Inagaki, Terumi

2017-10-01

Recently, small hydroelectric generators have gained attention as a further development in water turbine technology for ultra low head drops in open channels. The authors have evaluated the application of cross-flow water turbines in open channels as an undershot type after removing the casings and guide vanes to substantially simplify these water turbines. However, because undershot cross-flow water turbines are designed on the basis of cross-flow water turbine runners used in typical pipelines, it remains unclear whether the number of blades has an effect on the performance or flow fields. Thus, in this research, experiments and numerical analyses are employed to study the performance and flow fields of undershot cross-flow water turbines with varying number of blades. The findings show that the turbine output and torque are lower, the fluctuation is significantly higher, and the turbine efficiency is higher for runners with 8 blades as opposed to those with 24 blades.

Experimental validation and model development for thermal transmittances of porous window screens and horizontal louvred blind systems

DOE PAGES

Hart, Robert; Goudey, Howdy; Curcija, D. Charlie

2017-05-16

Virtually every home in the US has some form of shades, blinds, drapes, or other window attachment, but few have been designed for energy savings. In order to provide a common basis of comparison for thermal performance it is important to have validated simulation tools. This study outlines a review and validation of the ISO 15099 centre-of-glass thermal transmittance correlations for naturally ventilated cavities through measurement and detailed simulations. The focus is on the impacts of room-side ventilated cavities, such as those found with solar screens and horizontal louvred blinds. The thermal transmittance of these systems is measured experimentally, simulatedmore » using computational fluid dynamics analysis, and simulated utilizing simplified correlations from ISO 15099. Finally, correlation coefficients are proposed for the ISO 15099 algorithm that reduces the mean error between measured and simulated heat flux for typical solar screens from 16% to 3.5% and from 13% to 1% for horizontal blinds.« less

The effectiveness of psychosocial modalities in the treatment of alcohol problems in adults: a review of the evidence.

PubMed

Martin, Garth W; Rehm, Jürgen

2012-06-01

Our objectives were to review the effectiveness of psychosocial modalities in the treatment of alcohol use disorders and problems, and to examine the impact of therapists on treatment outcome, the evidence on best practices for comorbid conditions, and the evidence on treatment matching. We based our review on published systematic reviews of this topic after 2000. There is strong evidence that some, but not all, psychosocial treatments are effective in treating alcohol problems. Those with the strongest empirical support are motivational enhancement therapy, various cognitive-behavioural interventions, and brief interventions. Meta-analyses for several of these modalities suggest typical effect sizes in the low-to-moderate range. When these modalities have been compared with one another in well-designed clinical trials, they have been shown to be of comparable effectiveness. There is little basis on which to recommend one of these modalities over another but good reason to select from among them.

Automated alignment of a reconfigurable optical system using focal-plane sensing and Kalman filtering.

PubMed

Fang, Joyce; Savransky, Dmitry

2016-08-01

Automation of alignment tasks can provide improved efficiency and greatly increase the flexibility of an optical system. Current optical systems with automated alignment capabilities are typically designed to include a dedicated wavefront sensor. Here, we demonstrate a self-aligning method for a reconfigurable system using only focal plane images. We define a two lens optical system with 8 degrees of freedom. Images are simulated given misalignment parameters using ZEMAX software. We perform a principal component analysis on the simulated data set to obtain Karhunen-Loève modes, which form the basis set whose weights are the system measurements. A model function, which maps the state to the measurement, is learned using nonlinear least-squares fitting and serves as the measurement function for the nonlinear estimator (extended and unscented Kalman filters) used to calculate control inputs to align the system. We present and discuss simulated and experimental results of the full system in operation.

What's growing on General Practitioner's stethoscope?

PubMed

Carducci, A; Cargnelutti, M; Tassinari, F; Bizzarro, A; Cordio, G; Carletti, S; Maccarini, L; Pelissero, G

2016-01-01

Non-critical medical devices, as stethoscopes, have long been considered as vectors in microorganisms' transmission. Cleaning standards for non-critical medical equipment are often unclear. This study was designed to assess the attitude of General Practitioners (GPs) towards cleaning their stethoscope and the degree of microbiological contamination of doctor's instrument in outpatient setting. Observational, crossover study. A structured questionnaire was administered to GPs to test their knowledge about medical instrument's cleanliness recommendations and the surface of the diaphragm of their stethoscopes was analyzed for bacteriological isolates using mass spectrometry technique. Most of GPs declared they don't know cleaning recommendations for non-critical medical devices and a relevant bacterial growth was identified on the majority of the stethoscopes' membranes. Almost all microbiological isolates resulted typically found in cutaneous flora. We can't state that the GP's stethoscopes feature a risk of transmission for microbiological pathogens; anyway, because of the level of contamination we observed, cleaning recommendations to disinfect instruments on a regular basis should be better indicated.

Classification of adaptive memetic algorithms: a comparative study.

PubMed

Ong, Yew-Soon; Lim, Meng-Hiot; Zhu, Ning; Wong, Kok-Wai

2006-02-01

Adaptation of parameters and operators represents one of the recent most important and promising areas of research in evolutionary computations; it is a form of designing self-configuring algorithms that acclimatize to suit the problem in hand. Here, our interests are on a recent breed of hybrid evolutionary algorithms typically known as adaptive memetic algorithms (MAs). One unique feature of adaptive MAs is the choice of local search methods or memes and recent studies have shown that this choice significantly affects the performances of problem searches. In this paper, we present a classification of memes adaptation in adaptive MAs on the basis of the mechanism used and the level of historical knowledge on the memes employed. Then the asymptotic convergence properties of the adaptive MAs considered are analyzed according to the classification. Subsequently, empirical studies on representatives of adaptive MAs for different type-level meme adaptations using continuous benchmark problems indicate that global-level adaptive MAs exhibit better search performances. Finally we conclude with some promising research directions in the area.

Advocating for a Population-Specific Health Literacy for People With Visual Impairments.

PubMed

Harrison, Tracie; Lazard, Allison

2015-01-01

Health literacy, the ability to access, process, and understand health information, is enhanced by the visual senses among people who are typically sighted. Emotions, meaning, speed of knowledge transfer, level of attention, and degree of relevance are all manipulated by the visual design of health information when people can see. When consumers of health information are blind or visually impaired, they access, process, and understand their health information in a multitude of methods using a variety of accommodations depending upon their severity and type of impairment. They are taught, or they learn how, to accommodate their differences by using alternative sensory experiences and interpretations. In this article, we argue that due to the unique and powerful aspects of visual learning and due to the differences in knowledge creation when people are not visually oriented, health literacy must be considered a unique construct for people with visual impairment, which requires a distinctive theoretical basis for determining the impact of their mind-constructed representations of health.

Ferromagnetism induced by entangled charge and orbital orderings in ferroelectric titanate perovskites

PubMed Central

Bristowe, N. C.; Varignon, J.; Fontaine, D.; Bousquet, E.; Ghosez, Ph.

2015-01-01

In magnetic materials, the Pauli exclusion principle typically drives anti-alignment between electron spins on neighbouring species resulting in antiferromagnetic behaviour. Ferromagnetism exhibiting spontaneous spin alignment is a fairly rare behaviour, but once materialized is often associated with itinerant electrons in metals. Here we predict and rationalize robust ferromagnetism in an insulating oxide perovskite structure based on the popular titanate series. In half-doped layered titanates, the combination of Jahn–Teller and oxygen breathing motions opens a band gap and creates an unusual charge and orbital ordering of the Ti d electrons. It is argued that this intriguingly intricate electronic network favours the elusive inter-site ferromagnetic (FM) ordering, on the basis of intra-site Hund's rules. Finally, we find that the layered oxides are also ferroelectric with a spontaneous polarization approaching that of BaTiO3. The concepts are general and design principles of the technologically desirable FM ferroelectric multiferroics are presented. PMID:25807180

Research on breakdown characteristics of converter transformer oil-paper insulation under compound electric field in alpine region

NASA Astrophysics Data System (ADS)

Xu, C.; Gao, Z. W.; Lan, S.; Guo, H. X.; Gong, M. C.

2018-01-01

In the paper, existing research and operating experience was summarized. On the basis, the particularity of oil-paper insulation operation condition for converter transformer was combined for studying the influence of temperature on oil-paper insulation field intensity distribution of converter transformers under different AC contents within wide temperature scope (-40°C∼105°C). The law of temperature gradients on space charge accumulation was analyzed. The breakdown or flashover characteristics of typical oil-paper compound insulation structure under the action of DC, AC and AC-DC superposition voltage at different temperatures were explored. The design principles of converter transformer oil-paper insulation structures in alpine region was proposed. The principle was adjusted and optimized properly according to the operation temperature scope and withstood AC-DC proportion. The reliability of transformer operation was improved on the one hand, and the insulating medium can be rationally utilized for reducing the manufacturing cost of the transformer on the other hand.

A Process Algebraic Approach to Software Architecture Design

NASA Astrophysics Data System (ADS)

Aldini, Alessandro; Bernardo, Marco; Corradini, Flavio

Process algebra is a formal tool for the specification and the verification of concurrent and distributed systems. It supports compositional modeling through a set of operators able to express concepts like sequential composition, alternative composition, and parallel composition of action-based descriptions. It also supports mathematical reasoning via a two-level semantics, which formalizes the behavior of a description by means of an abstract machine obtained from the application of structural operational rules and then introduces behavioral equivalences able to relate descriptions that are syntactically different. In this chapter, we present the typical behavioral operators and operational semantic rules for a process calculus in which no notion of time, probability, or priority is associated with actions. Then, we discuss the three most studied approaches to the definition of behavioral equivalences - bisimulation, testing, and trace - and we illustrate their congruence properties, sound and complete axiomatizations, modal logic characterizations, and verification algorithms. Finally, we show how these behavioral equivalences and some of their variants are related to each other on the basis of their discriminating power.

CADMIO: computer aided design for medical information objects.

PubMed

Minarelli, D V; Ferri, F; Pisanelli, D M; Ricci, F L; Tittarelli, F

1995-01-01

The growth of the computational capability and the tools of graphic software is nowadays available in an integrated manner into the development environments, thus permitting the realization of tool kits capable of handling information that is complex and of different kinds such as the typical medical information. This has given a great impulse to the creation of electronic medical folders joining together with new and stimulating functionality with respect to the usual paper document [1]. In the present work, we propose a tool capable of defining a multimedia electronic medical folder and representing its architecture through a layout that is formed on the basis of the particular data types to be handled. This tool is capable of providing an integrated view of data that, even though they are close in cognitive sense, are often stored and represented apart in the practice. Different approaches to the browsing feature are giving within the system, thus the user can personalize the way of viewing the information stored into the folder or can let the system guide the browsing.

[Italian Society of Hygiene (SItI) recommendations for a healthy, safe and sustainable housing].

PubMed

Signorelli, Carlo; Capolongo, Stefano; Buffoli, Maddalena; Capasso, Lorenzo; Faggioli, Antonio; Moscato, Umberto; Oberti, Ilaria; Petronio, Maria Grazia; D'Alessandro, Daniela

2016-01-01

As part of the strategies to promote health in urban areas, the Italian Society of Hygiene (SItI) has updated its recommendations for healthy, safe and sustainable housing. They were issued by an ad hoc SitI working group on the basis of the best available evidence retrieved from a review of the scientific and legal literature on the topic and in line with World Health Organisation, European Union, and other international bodies statements. SItI document includes recommendations for environmental comfort, mental and social wellbeing, environmental protection as well as the safety of people who dwell houses. In addition to typical issues (such as relative humidity parameters, ventilation, and safety rules), SItI recommendations address innovative aspects such as building compatibility between different functions, building safety management and green area design. In this context, SItI recommendations emphasise the need of a strengthened interaction between architects and public health experts to ensure the complete wellbeing in houses where people spend more than 50% of their lives.

Dark Photocatalysis: Storage of Solar Energy in Carbon Nitride for Time-Delayed Hydrogen Generation.

PubMed

Lau, Vincent Wing-Hei; Klose, Daniel; Kasap, Hatice; Podjaski, Filip; Pignié, Marie-Claire; Reisner, Erwin; Jeschke, Gunnar; Lotsch, Bettina V

2017-01-09

While natural photosynthesis serves as the model system for efficient charge separation and decoupling of redox reactions, bio-inspired artificial systems typically lack applicability owing to synthetic challenges and structural complexity. We present herein a simple and inexpensive system that, under solar irradiation, forms highly reductive radicals in the presence of an electron donor, with lifetimes exceeding the diurnal cycle. This radical species is formed within a cyanamide-functionalized polymeric network of heptazine units and can give off its trapped electrons in the dark to yield H 2 , triggered by a co-catalyst, thus enabling the temporal decoupling of the light and dark reactions of photocatalytic hydrogen production through the radical's longevity. The system introduced here thus demonstrates a new approach for storing sunlight as long-lived radicals, and provides the structural basis for designing photocatalysts with long-lived photo-induced states. © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Research as a guide for teaching introductory mechanics: An illustration in the context of the Atwood's machine

NASA Astrophysics Data System (ADS)

McDermott, Lillian C.; Shaffer, Peter S.; Somers, Mark D.

1994-01-01

A problem on the Atwood's machine is often introduced early in the teaching of dynamics to demonstrate the application of Newton's laws to the motion of a compound system. In a series of preliminary studies, student understanding of the Atwood's machine was examined after this topic had been covered in a typical calculus-based course. Analysis of the data revealed that many students had serious difficulties with the acceleration, the internal and external forces, and the role of the string. The present study was undertaken to obtain more detailed information about the nature and prevalence of these difficulties and thus provide a sound basis for the design of more effective instruction. The context for the investigation is a group of related problems involving less complicated compound systems. Specific examples illustrate how this research, which was conducted primarily in a classroom setting, has served as a guide in the development of tutorial materials to supplement the lectures and textbook in a standard introductory course.

Derivation of Rigid Body Analysis Models from Vehicle Architecture Abstractions

DTIC Science & Technology

2011-06-17

models of every type have their basis in some type of physical representation of the design domain. Rather than describing three-dimensional continua of...arrangement, while capturing just enough physical detail to be used as the basis for a meaningful representation of the design , and eventually, analyses that...permit architecture assessment. The design information captured by the abstractions is available at the very earliest stages of the vehicle

Spent nuclear fuel canister storage building conceptual design report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swenson, C.E.

This Conceptual Design Report provides the technical basis for the Spent Nuclear Fuels Project, Canister Storage Building, and as amended by letter (correspondence number 9555700, M.E. Witherspoon to E.B. Sellers, ``Technical Baseline and Updated Cost Estimate for the Canister Storage Building``, dated October 24, 1995), includes the project cost baseline and Criteria to be used as the basis for starting detailed design in fiscal year 1995.

Mapping attractor fields in face space: the atypicality bias in face recognition.

PubMed

Tanaka, J; Giles, M; Kremen, S; Simon, V

1998-09-01

A familiar face can be recognized across many changes in the stimulus input. In this research, the many-to-one mapping of face stimuli to a single face memory is referred to as a face memory's 'attractor field'. According to the attractor field approach, a face memory will be activated by any stimuli falling within the boundaries of its attractor field. It was predicted that by virtue of its location in a multi-dimensional face space, the attractor field of an atypical face will be larger than the attractor field of a typical face. To test this prediction, subjects make likeness judgments to morphed faces that contained a 50/50 contribution from an atypical and a typical parent face. The main result of four experiments was that the morph face was judged to bear a stronger resemblance to the atypical face parent than the typical face parent. The computational basis of the atypicality bias was demonstrated in a neural network simulation where morph inputs of atypical and typical representations elicited stronger activation of atypical output units than of typical output units. Together, the behavioral and simulation evidence supports the view that the attractor fields of atypical faces span over a broader region of face space that the attractor fields of typical faces.

Technological and safety properties display biodiversity among enterococci isolated from two Egyptian cheeses, "Ras" and "Domiati".

PubMed

Malek, Reine; El-Attar, Aisha; Mohamed, Mariam; Anwar, Shimaa; El-Soda, Morsi; Béal, Catherine

2012-02-15

The technological and safety properties of 35 indigenous strains of Enterococcus faecium isolated from two Egyptian cheeses were characterised in order to determine their ability for rational manufacture of diversified and typical dairy products in the Middle East. A great diversity was observed within the 35 strains on the basis of their technological properties. A statistical analysis made it possible to distribute the 35 strains of E. faecium into different groups. Three groups were identified in terms of their acidification activity, measured by the Cinac system: a group of strains that quickly acidified milk, a second that moderately acidified milk, and a last cluster that revealed weak acidification activity. On the basis of texturing properties that were evaluated using a texturometer and a viscometer, a cluster of strains produced viscous and firm gels, a second cluster included fairly viscous, firm and cohesive gels, and a last group generated slightly viscous, but firm and very cohesive gels. By considering the aroma profiles that were determined by gas chromatography coupled with mass spectrometry, four clusters were identified. One cluster displayed a high dimethyl disulfide level, a second group of strains was highly aromatic, a third cluster led to typical "lactic" products, and the last cluster made it possible to obtain low aromatic products. None of the 35 strains proved to be β-haemolytic on the basis of the characterisation of their safety properties. The resistance to 20 antibiotics was assessed by the disc diffusion method. The 35 isolates were sensitive to 12 antibiotics, and among them, one isolate was resistant to only two antibiotics (nalixidic acid and streptomycin). The resistance to eight antibiotics was strain-dependant. Finally, this study demonstrates that some indigenous strains of E. faecium displayed interesting technological properties for cheese manufacture, together with good safety characteristics. They could be useful for the manufacture of typical products in Egypt. Copyright © 2011 Elsevier B.V. All rights reserved.

Construction of Fine Particles Source Spectrum Bank in Typical Region and Empirical Research of Matching Diagnosis

NASA Astrophysics Data System (ADS)

Wang, Xing; Sun, Wenliang; Guo, Min; Li, Minjiao; Li, Wan

2018-01-01

The research object of this paper is fine particles in typical region. The construction of component spectrum bank is based on the technology of online source apportionment, then the result of the apportionment is utilized to verify the effectiveness of fine particles component spectrum bank and which also act as the matching basis of online source apportionment receptor sample. On the next, the particle source of air pollution is carried through the matching diagnosis empirical research by utilizing online source apportionment technology, to provide technical support for the cause analysis and treatment of heavy pollution weather.

Morphological features of an endangered Japanese strain of Cyprinus carpio: reconstruction based on seven SNP markers.

PubMed

Atsumi, K; Song, H Y; Senou, H; Inoue, K; Mabuchi, K

2017-03-01

Morphological analyses of 183 specimens of Japanese common carp Cyprinus carpio (171 from Lake Biwa and 12 from nursery ponds) using genetic hybrid indices demonstrated that the typical native Japanese strain of C. carpio has a more elongate body, more branched dorsal-fin rays, fewer and shorter gill rakers, more developed pneumatic bulb, more coiled pneumatic duct, longer posterior swimbladder and shorter intestine than the typical introduced C. carpio. These results provide a basis for a better understanding of the ecological characteristics and taxonomic status of the endangered Japanese strain of C. carpio. © 2016 The Fisheries Society of the British Isles.

Preliminary Design Phases, Part of Indoor Air Quality Design Tools for Schools

EPA Pesticide Factsheets

The typical design process for schools begins with programming and selection of the architectural-engineering team. It then proceeds through schematic design, design development, contract documents, construction, commissioning and occupancy.

Quantitative analysis and comparative study of four cities green pattern in API system on the background of big data

NASA Astrophysics Data System (ADS)

Xin, YANG; Si-qi, WU; Qi, ZHANG

2018-05-01

Beijing, London, Paris, New York are typical cities in the world, so comparative study of four cities green pattern is very important to find out gap and advantage and to learn from each other. The paper will provide basis and new ideas for development of metropolises in China. On the background of big data, API (Application Programming Interface) system can provide extensive and accurate basic data to study urban green pattern in different geographical environment in domestic and foreign. On the basis of this, Average nearest neighbor tool, Kernel density tool and Standard Ellipse tool in ArcGIS platform can process and summarize data and realize quantitative analysis of green pattern. The paper summarized uniqueness of four cities green pattern and reasons of formation on basis of numerical comparison.

Resonant Spin-Transfer-Torque Nano-Oscillators

NASA Astrophysics Data System (ADS)

Sharma, Abhishek; Tulapurkar, Ashwin A.; Muralidharan, Bhaskaran

2017-12-01

Spin-transfer-torque nano-oscillators are potential candidates for replacing the traditional inductor-based voltage-controlled oscillators in modern communication devices. Typical oscillator designs are based on trilayer magnetic tunnel junctions, which have the disadvantages of low power outputs and poor conversion efficiencies. We theoretically propose using resonant spin filtering in pentalayer magnetic tunnel junctions as a possible route to alleviate these issues and present viable device designs geared toward a high microwave output power and an efficient conversion of the dc input power. We attribute these robust qualities to the resulting nontrivial spin-current profiles and the ultrahigh tunnel magnetoresistance, both of which arise from resonant spin filtering. The device designs are based on the nonequilibrium Green's-function spin-transport formalism self-consistently coupled with the stochastic Landau-Lifshitz-Gilbert-Slonczewski equation and Poisson's equation. We demonstrate that the proposed structures facilitate oscillator designs featuring a large enhancement in microwave power of around 1150% and an efficiency enhancement of over 1100% compared to typical trilayer designs. We rationalize the optimum operating regions via an analysis of the dynamic and static device resistances. We also demonstrate the robustness of our structures against device design fluctuations and elastic dephasing. This work sets the stage for pentalyer spin-transfer-torque nano-oscillator device designs that ameliorate major issues associated with typical trilayer designs.

10 CFR Appendix C to Part 73 - Nuclear Power Plant Safeguards Contingency Plans

Code of Federal Regulations, 2011 CFR

2011-01-01

... command and delegation of authority as these apply to safeguards contingencies. b. Physical Layout—(i..., up to and including the design basis threat of radiological sabotage. The goals of licensee.... Perceived Danger—Consistent with the design basis threat specified in § 73.1(a)(1), licensees shall identify...

78 FR 50454 - Entergy Operations, Inc., River Bend Station, Unit 1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

... containment internal pressure related to the design basis accident specified either in the technical... RBS to continue to use the pre-extended power uprate value of 7.6 psig rather than use the newly... period following a design basis accident. The Need for the Proposed Action The proposed exemption is...

Reconfigurable Flight Control Design using a Robust Servo LQR and Radial Basis Function Neural Networks

NASA Technical Reports Server (NTRS)

Burken, John J.

2005-01-01

This viewgraph presentation reviews the use of a Robust Servo Linear Quadratic Regulator (LQR) and a Radial Basis Function (RBF) Neural Network in reconfigurable flight control designs in adaptation to a aircraft part failure. The method uses a robust LQR servomechanism design with model Reference adaptive control, and RBF neural networks. During the failure the LQR servomechanism behaved well, and using the neural networks improved the tracking.

Turbofan Engine Core Compartment Vent Aerodynamic Configuration Development Methodology

NASA Technical Reports Server (NTRS)

Hebert, Leonard J.

2006-01-01

This paper presents an overview of the design methodology used in the development of the aerodynamic configuration of the nacelle core compartment vent for a typical Boeing commercial airplane together with design challenges for future design efforts. Core compartment vents exhaust engine subsystem flows from the space contained between the engine case and the nacelle of an airplane propulsion system. These subsystem flows typically consist of precooler, oil cooler, turbine case cooling, compartment cooling and nacelle leakage air. The design of core compartment vents is challenging due to stringent design requirements, mass flow sensitivity of the system to small changes in vent exit pressure ratio, and the need to maximize overall exhaust system performance at cruise conditions.

The Effects of Social and Experiential Factors on the Interactions between the Phonetic Systems of Diglossic Bilinguals

ERIC Educational Resources Information Center

Law, Wai Ling

2017-01-01

In diglossic contexts, when speakers typically use two different languages on a regular basis, bilingual speakers display a wide array of attitudes towards each of their languages and associated cultures (Galindo, 1995) and such variability in attitudes can affect their linguistic behaviors (Lambert, Hodgson, Gardner & Fillenbaum, 1960).…

A polygon-based modeling approach to assess exposure of resources and assets to wildfire

Treesearch

Matthew P. Thompson; Joe Scott; Jeffrey D. Kaiden; Julie W. Gilbertson-Day

2013-01-01

Spatially explicit burn probability modeling is increasingly applied to assess wildfire risk and inform mitigation strategy development. Burn probabilities are typically expressed on a per-pixel basis, calculated as the number of times a pixel burns divided by the number of simulation iterations. Spatial intersection of highly valued resources and assets (HVRAs) with...

Communicate with Parents in 7 Simple Steps

ERIC Educational Resources Information Center

Balsley, Jessica

2011-01-01

The relationship between art teachers and students' families is a complex one. Because they typically see a large volume of students in a short amount of time, art teachers are rarely the first line of communication when it comes to connecting with families on a regular basis. Most often, communication only occurs when the teacher has great news…

Returning to School for Higher Returns

ERIC Educational Resources Information Center

Park, Seonyoung

2011-01-01

On the basis of those respondents in the National Longitudinal Survey of Youth (NLSY) who change jobs with an intervening period of education reinvestment, the conventional assumption of linearity of log wages in years of schooling is strongly rejected: a typical reinvestment for the 1980 through 1993 period is associated with a rise of about 3.5…

Imaging in the assessment and management of athletic pubalgia.

PubMed

Robinson, Philip; Bhat, Vineet; English, Bryan

2011-02-01

This article reviews the clinical, anatomical, and biomechanical basis of pubalgia and relates it to the potential imaging findings and subsequent management. Although the magnetic resonance imaging features typically seen in symptomatic athletes are emphasized, this condition remains a complex clinical problem, and treatment addressing the functional rehabilitation of the entire region is highlighted. © Thieme Medical Publishers.

Use of Event-Related Potentials in the Study of Typical and Atypical Development

ERIC Educational Resources Information Center

Nelson, Charles A., III; McCleery, Joseph P.

2008-01-01

Event-related potential is a kind of neuroimaging tool which can be used in the study of neurodevelopment. Two areas of atypical development, children diagnosed with autism and children experiencing early psychosocial neglect, have benefited from ERPs. The physiological basis of ERPs and the constraints on their applications are also discussed.

Data Collaborative: A Practical Exploration of Big Data in Course Wikis

ERIC Educational Resources Information Center

Percell, Jay C.

2016-01-01

Wikis continue to be used within technology environments of K-12 and higher education because they offer a collaborative environment for students to produce and receive content in concert with each other or on an individual basis (Kirkham, 2014). These online spaces are typically used as a course management system where students can both receive…

Non-Association between Neo-5 Personality Tests and Multiple Mini-Interview

ERIC Educational Resources Information Center

Kulasegaram, Kulamakan; Reiter, Harold I.; Wiesner, Willi; Hackett, Richard D.; Norman, Geoffrey R.

2010-01-01

Most medical schools attempt to select applicants on the basis of cognitive and non-cognitive skills. Typically, interpersonal skills are assessed by interview, though relatively few applicants make it to interview. Thus, an efficient paper and pencil test of non-cognitive skills is needed. One possibility is personality tests. Tests of the five…

Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD)

ERIC Educational Resources Information Center

Groom, Madeleine J.; Kochhar, Puja; Hamilton, Antonia; Liddle, Elizabeth B.; Simeou, Marina; Hollis, Chris

2017-01-01

This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects…

Where Am I? A Change of Basis Project

ERIC Educational Resources Information Center

Selby, Christina

2016-01-01

Linear algebra students are typically introduced to the problem of how to convert from one coordinate system to another in a very abstract way. Often, two bases for a given vector space are provided, and students are taught how to determine a transition matrix to be used for changing coordinates. If students are successful in memorizing this…

Sex, Money and the Equal Pay Act

ERIC Educational Resources Information Center

Feldman, Edwin B.

1973-01-01

Institutions who justify a wage differential between male and female custodians on the basis that women typically do the lighter work, and men the heavier, can find themselves in trouble. The Equal Pay Act of 1963 requires that men and women get the same pay for equal work -- and all custodial work is substantially equal to the Labor Department.…

Hydrogen peroxide and caustic soda: Dancing with a dragon while bleaching

Treesearch

Peter W. Hart; Carl Houtman; Kolby Hirth

2013-01-01

When hydrogen peroxide is mixed with caustic soda, an auto-accelerating reaction can lead to generation of significant amounts of heat and oxygen. On the basis of experiments using typical pulp mill process concentration and temperatures, a relatively simple kinetic model has been developed. Evaluation of these model results reveals that hydrogen peroxide-caustic soda...

On the formation of dense understory layers in forests worldwide: consequences and implications for forest dynamics, biodiversity, and succession

Treesearch

Alejandro A. Royo; Walter P. Carson

2006-01-01

The mechanistic basis underpinning forest succession is the gap-phase paradigm in which overstory disturbance interacts with seedling and sapling shade tolerance to determine successional trajectories. The theory, and ensuing simulation models, typically assume that understory plants have little impact on the advance regeneration layer's composition. We challenge...

Outdoor Adventure in Australian Outdoor Education: Is It a Case of Roast for Christmas Dinner?

ERIC Educational Resources Information Center

Lugg, Alison

2004-01-01

Outdoor adventure activities, typically originating from other countries, form the basis of most Australian outdoor education programs. Research on adventure-based outdoor education in Australia and elsewhere has tended to focus on determining the benefits of participating in such programs. Less attention has been paid to a critical examination of…

Social Network Changes and Life Events across the Life Span: A Meta-Analysis

ERIC Educational Resources Information Center

Wrzus, Cornelia; Hanel, Martha; Wagner, Jenny; Neyer, Franz J.

2013-01-01

For researchers and practitioners interested in social relationships, the question remains as to how large social networks typically are, and how their size and composition change across adulthood. On the basis of predictions of socioemotional selectivity theory and social convoy theory, we conducted a meta-analysis on age-related social network…

Neural Basis of Irony Comprehension in Children with Autism: The Role of Prosody and Context

ERIC Educational Resources Information Center

Wang, A. Ting; Lee, Susan S.; Sigman, Marian; Dapretto, Mirella

2006-01-01

While individuals with autism spectrum disorders (ASD) are typically impaired in interpreting the communicative intent of others, little is known about the neural bases of higher-level pragmatic impairments. Here, we used functional MRI (fMRI) to examine the neural circuitry underlying deficits in understanding irony in high-functioning children…

29 CFR 4.131 - Furnishing services involving more than use of labor.

Code of Federal Regulations, 2013 CFR

2013-07-01

... laundered items on a rental basis. It is plain from the legislative history that such a contract is typical..., computer services, and the like are within the general coverage of the Act even though the contractor may be required to furnish such tangible items as written reports or computer printouts, since items of...

29 CFR 4.131 - Furnishing services involving more than use of labor.

Code of Federal Regulations, 2014 CFR

2014-07-01

... laundered items on a rental basis. It is plain from the legislative history that such a contract is typical..., computer services, and the like are within the general coverage of the Act even though the contractor may be required to furnish such tangible items as written reports or computer printouts, since items of...

29 CFR 4.131 - Furnishing services involving more than use of labor.

Code of Federal Regulations, 2012 CFR

2012-07-01

... laundered items on a rental basis. It is plain from the legislative history that such a contract is typical..., computer services, and the like are within the general coverage of the Act even though the contractor may be required to furnish such tangible items as written reports or computer printouts, since items of...

Hadron-quark crossover and hot neutron stars at birth

NASA Astrophysics Data System (ADS)

Masuda, Kota; Hatsuda, Tetsuo; Takatsuka, Tatsuyuki

2016-02-01

We construct a new isentropic equation of state (EOS) at finite temperature, "CRover," on the basis of the hadron-quark crossover at high density. By using the new EOS, we study the structure of hot neutron stars at birth with typical lepton fraction (Y_l=0.3-0.4) and typical entropy per baryon (hat {S}=1{-}2). Due to the gradual appearance of quark degrees of freedom at high density, the temperature T and the baryon density ρ at the center of hot neutron stars with hadron-quark crossover are found to be smaller than those without the crossover by a factor of two or more. Typical energy release due to the contraction of a hot neutron star to a cold neutron star with mass M=1.4 M_{⊙} is shown to be about 0.04 M_{⊙}, with a spin-up rate of about 14%.

Mariner 9 mapping science sequence design.

NASA Technical Reports Server (NTRS)

Goldman, A. M., Jr.

1973-01-01

The primary mission of Mariner 9 was to map the Martian surface. This paper discusses in detail the design of the mapping science sequences which were executed by the spacecraft in sixty days and during which over eighty percent of the surface was photographed. The sequence design was influenced by many factors: experimenter scientific objectives, instrument capabilities, spacecraft capabilities, orbit characteristics, and data return rates, which are illustrated graphically. Typical orbits are depicted for each of the three different mapping phases lasting twenty days. Examples of typical orbital sequence plans prepared daily during mission operations are given.

Design, fabrication and characterization of a micro-fluxgate intended for parallel robot application

NASA Astrophysics Data System (ADS)

Kirchhoff, M. R.; Bogdanski, G.; Büttgenbach, S.

2009-05-01

This paper presents a micro-magnetometer based on the fluxgate principle. Fluxgates detect the magnitude and direction of DC and low-frequency AC magnetic fields. The detectable flux density typically ranges from several 10 nT to about 1 mT. The introduced fluxgate sensor is fabricated using MEMS-technologies, basically UV depth lithography and electroplating for manufacturing high aspect ratio structures. It consists of helical copper coils around a soft magnetic nickel-iron (NiFe) core. The core is designed in so-called racetrack geometry, whereby the directional sensitivity of the sensor is considerably higher compared to common ring-core fluxgates. The electrical operation is based on analyzing the 2nd harmonic of the AC output signal. Configuration, manufacturing and selected characteristics of the fluxgate magnetometer are discussed in this work. The fluxgate builds the basis of an innovative angular sensor system for a parallel robot with HEXA-structure. Integrated into the passive joints of the parallel robot, the fluxgates are combined with permanent magnets rotating on the joint shafts. The magnet transmits the angular information via its magnetic orientation. In this way, the angles between the kinematic elements are measured, which allows self-calibration of the robot and the fast analytical solution of direct kinematics for an advanced workspace monitoring.

Experimental design of an interlaboratory study for trace metal analysis of liquid fluids. [for aerospace vehicles

NASA Technical Reports Server (NTRS)

Greenbauer-Seng, L. A.

1983-01-01

The accurate determination of trace metals and fuels is an important requirement in much of the research into and development of alternative fuels for aerospace applications. Recognizing the detrimental effects of certain metals on fuel performance and fuel systems at the part per million and in some cases part per billion levels requires improved accuracy in determining these low concentration elements. Accurate analyses are also required to ensure interchangeability of analysis results between vendor, researcher, and end use for purposes of quality control. Previous interlaboratory studies have demonstrated the inability of different laboratories to agree on the results of metal analysis, particularly at low concentration levels, yet typically good precisions are reported within a laboratory. An interlaboratory study was designed to gain statistical information about the sources of variation in the reported concentrations. Five participant laboratories were used on a fee basis and were not informed of the purpose of the analyses. The effects of laboratory, analytical technique, concentration level, and ashing additive were studied in four fuel types for 20 elements of interest. The prescribed sample preparation schemes (variations of dry ashing) were used by all of the laboratories. The analytical data were statistically evaluated using a computer program for the analysis of variance technique.

Shape-optimization of round-to-slot holes for improving film cooling effectiveness on a flat surface

NASA Astrophysics Data System (ADS)

Huang, Ying; Zhang, Jing-zhou; Wang, Chun-hua

2018-01-01

Single-objective optimization for improving adiabatic film cooling effectiveness is performed for single row of round-to-slot film cooling holes on a flat surface by using CFD analysis and surrogate approximation methods. Among the main geometric parameters, dimensionless hole-to-hole pitch (P/d) and slot length-to-diameter (l/d) are fixed as 2.4 and 2 respectively, and the other parameters (hole height-to-diameter ratio, slot width-to-diameter and inclination angle) are chosen as the design variables. Given a wide range of possible geometric variables, the geometric optimization of round-to-slot holes is carried out under two typical blowing ratios of M = 0.5 and M = 1.5 by selecting a spatially-averaged adiabatic film cooling effectiveness between x/d = 2 and x/d = 12 as the objective function to be maximized. Radial basis function neural network is applied for constructing the surrogate model and then the optimal design point is searched by a genetic algorithm. It is revealed that the optimal round-to-slot hole is of converging feature under a low blowing ratio but of diffusing feature under a high blowing ratio. Further, the influence principle of optimal round-to-slot geometry on film cooling performance is illustrated according to the detailed flow and thermal behaviors.

What could they have been thinking? How sociotechnical system design influences cognition: a case study of the Stockwell shooting.

PubMed

Jenkins, Daniel P; Salmon, Paul M; Stanton, Neville A; Walker, Guy H; Rafferty, Laura

2011-02-01

Understanding why an individual acted in a certain way is of fundamental importance to the human factors community, especially when the choice of action results in an undesirable outcome. This challenge is typically tackled by applying retrospective interview techniques to generate models of what happened, recording deviations from a 'correct procedure'. While such approaches may have great utility in tightly constrained procedural environments, they are less applicable in complex sociotechnical systems that require individuals to modify procedures in real time to respond to a changing environment. For complex sociotechnical systems, a formative approach is required that maps the information available to the individual and considers its impact on performance and action. A context-specific, activity-independent, constraint-based model forms the basis of this approach. To illustrate, an example of the Stockwell shooting is used, where an innocent man, mistaken for a suicide bomber, was shot dead. Transferable findings are then presented. STATEMENT OF RELEVANCE: This paper presents a new approach that can be applied proactively to consider how sociotechnical system design, and the information available to an individual, can affect their performance. The approach is proposed to be complementary to the existing tools in the mental models phase of the cognitive work analysis framework.

Investigation of a less rare-earth permanent-magnet machine with the consequent pole rotor

NASA Astrophysics Data System (ADS)

Bai, Jingang; Liu, Jiaqi; Wang, Mingqiao; Zheng, Ping; Liu, Yong; Gao, Haibo; Xiao, Lijun

2018-05-01

Due to the rising price of rare-earth materials, permanent-magnet (PM) machines in different applications have a trend of reducing the use of rare-earth materials. Since iron-core poles replace half of PM poles in the consequent pole (CP) rotor, the PM machine with CP rotor can be a promising candidate for less rare-earth PM machine. Additionally, the investigation of CP rotor in special electrical machines, like hybrid excitation permanent-magnet PM machine, bearingless motor, etc., has verified the application feasibility of CP rotor. Therefore, this paper focuses on design and performance of PM machines when traditional PM machine uses the CP rotor. In the CP rotor, all the PMs are of the same polarity and they are inserted into the rotor core. Since the fundamental PM flux density depends on the ratio of PM pole to iron-core pole, the combination rule between them is investigated by analytical and finite-element methods. On this basis, to comprehensively analyze and evaluate PM machine with CP rotor, four typical schemes, i.e., integer-slot machines with CP rotor and surface-mounted PM (SPM) rotor, fractional-slot machines with CP rotor and SPM rotor, are designed to investigate the performance of PM machine with CP rotor, including electromagnetic performance, anti-demagnetization capacity and cost.

Life Test Approach for Refractory Metal/Sodium Heat Pipes

NASA Technical Reports Server (NTRS)

Martin, James J.; Reid, Robert S.

2006-01-01

Heat pipe life tests described in the literature have seldom been conducted on a systematic basis. Typically one or more heat pipes are built and tested for an extended period at a single temperature with simple condenser loading. This paper describes an approach to generate carefully controlled data that can conclusively establish heat pipe operating life with material-fluid combinations capable of extended operation. Approximately 10 years of operational life might be compressed into 3 years of laboratory testing through a combination of increased temperature and mass fluence. Two specific test series have been identified and include: investigation of long term corrosion rates based on the guidelines contained in ASTM G-68-80 (using 7 heat pipes); and investigation of corrosion trends in a cross correlation sequence at various temperatures and mass fluences based on a central composite test design (using 9 heat pipes). The heat pipes selected for demonstration purposes are fabricated from a Mo-44.5%Re alloy with a length of 0.3 meters and a diameter of 1.59 cm(to conserve material) with a condenser to evaporator length ratio of approximately 3. The wick is a crescent annular design formed from 400-mesh Mo-Re alloy material hot isostatically pressed to produce a final wick core of 20 microns or less.

PATRIC: the Comprehensive Bacterial Bioinformatics Resource with a Focus on Human Pathogenic Species ▿ ‡ #

PubMed Central

Gillespie, Joseph J.; Wattam, Alice R.; Cammer, Stephen A.; Gabbard, Joseph L.; Shukla, Maulik P.; Dalay, Oral; Driscoll, Timothy; Hix, Deborah; Mane, Shrinivasrao P.; Mao, Chunhong; Nordberg, Eric K.; Scott, Mark; Schulman, Julie R.; Snyder, Eric E.; Sullivan, Daniel E.; Wang, Chunxia; Warren, Andrew; Williams, Kelly P.; Xue, Tian; Seung Yoo, Hyun; Zhang, Chengdong; Zhang, Yan; Will, Rebecca; Kenyon, Ronald W.; Sobral, Bruno W.

2011-01-01

Funded by the National Institute of Allergy and Infectious Diseases, the Pathosystems Resource Integration Center (PATRIC) is a genomics-centric relational database and bioinformatics resource designed to assist scientists in infectious-disease research. Specifically, PATRIC provides scientists with (i) a comprehensive bacterial genomics database, (ii) a plethora of associated data relevant to genomic analysis, and (iii) an extensive suite of computational tools and platforms for bioinformatics analysis. While the primary aim of PATRIC is to advance the knowledge underlying the biology of human pathogens, all publicly available genome-scale data for bacteria are compiled and continually updated, thereby enabling comparative analyses to reveal the basis for differences between infectious free-living and commensal species. Herein we summarize the major features available at PATRIC, dividing the resources into two major categories: (i) organisms, genomes, and comparative genomics and (ii) recurrent integration of community-derived associated data. Additionally, we present two experimental designs typical of bacterial genomics research and report on the execution of both projects using only PATRIC data and tools. These applications encompass a broad range of the data and analysis tools available, illustrating practical uses of PATRIC for the biologist. Finally, a summary of PATRIC's outreach activities, collaborative endeavors, and future research directions is provided. PMID:21896772

Shape-optimization of round-to-slot holes for improving film cooling effectiveness on a flat surface

NASA Astrophysics Data System (ADS)

Huang, Ying; Zhang, Jing-zhou; Wang, Chun-hua

2018-06-01

Single-objective optimization for improving adiabatic film cooling effectiveness is performed for single row of round-to-slot film cooling holes on a flat surface by using CFD analysis and surrogate approximation methods. Among the main geometric parameters, dimensionless hole-to-hole pitch ( P/ d) and slot length-to-diameter ( l/ d) are fixed as 2.4 and 2 respectively, and the other parameters (hole height-to-diameter ratio, slot width-to-diameter and inclination angle) are chosen as the design variables. Given a wide range of possible geometric variables, the geometric optimization of round-to-slot holes is carried out under two typical blowing ratios of M = 0.5 and M = 1.5 by selecting a spatially-averaged adiabatic film cooling effectiveness between x/ d = 2 and x/ d = 12 as the objective function to be maximized. Radial basis function neural network is applied for constructing the surrogate model and then the optimal design point is searched by a genetic algorithm. It is revealed that the optimal round-to-slot hole is of converging feature under a low blowing ratio but of diffusing feature under a high blowing ratio. Further, the influence principle of optimal round-to-slot geometry on film cooling performance is illustrated according to the detailed flow and thermal behaviors.

Synthesis of a fully-integrated digital signal source for communications from chaotic dynamics-based oscillations

NASA Astrophysics Data System (ADS)

Glenn, Chance Michael, Sr.

This work is the conceptualization, derivation, analysis, and fabrication of a fully practical digital signal source designed from a chaotic oscillator. In it we show how a simple electronic circuit based upon the Colpitts oscillator, can be made to produce highly complex signals capable of carrying digital information. We show a direct relationship between the continuous-time chaotic oscillations produced by the circuit and the logistic map, which is discrete-time, one-dimensional map that is a fundamental paradigm for the study of chaotic systems. We demonstrate the direct encoding of binary information into the oscillations of the chaotic circuit. We demonstrate a new concept in power amplification, called syncrodyne amplification , which uses fundamental properties of chaotic oscillators to provide high-efficiency, high gain amplification of standard communication waveforms as well as typical chaotic oscillations. We show modeling results of this system providing nearly 60-dB power gain and 80% PAE for communications waveforms conforming to GMSK modulation. Finally we show results from a fabricated syncrodyne amplifier circuit operating at 2 MHz, providing over 40-dB power gain and 72% PAE, and propose design criteria for an 824--850 MHz circuit utilizing heterojunction bipolar transistors (HBTs), providing the basis for microwave frequency realization.

Concept, design and analysis of a large format autostereoscopic display system

NASA Astrophysics Data System (ADS)

Knocke, F.; de Jongh, R.; Frömel, M.

2005-09-01

Autostereoscopic display devices with large visual field are of importance in a number of applications such as computer aided design projects, technical education, and military command systems. Typical requirements for such systems are, aside from the large visual field, a large viewing zone, a high level of image brightness, and an extended depth of field. Additional appliances such as specialized eyeglasses or head-trackers are disadvantageous for the aforementioned applications. We report on the design and prototyping of an autostereoscopic display system on the basis of projection-type one-step unidirectional holography. The prototype consists of a hologram holder, an illumination unit, and a special direction-selective screen. Reconstruction light is provided by a 2W frequency-doubled Nd:YVO4 laser. The production of stereoscopic hologram stripes on photopolymer is carried out on a special origination setup. The prototype has a screen size of 180cm × 90cm and provides a visual field of 29° when viewed from 3.6 meters. Due to the coherent reconstruction, a depth of field of several meters is achievable. Up to 18 hologram stripes can be arranged on the holder to permit a rapid switch between a series of motifs or views. Both computer generated image sequences and digital camera photos may serve as input frames. However, a comprehensive pre-distortion must be performed in order to account for optical distortion and several other geometrical factors. The corresponding computations are briefly summarized below. The performance of the system is analyzed, aspects of beam-shaping and mechanical design are discussed and photographs of early reconstructions are presented.

Optimizing defect inspection strategy through the use of design-aware database control layers

NASA Astrophysics Data System (ADS)

Stoler, Dvori; Ruch, Wayne; Ma, Weimin; Chakravarty, Swapnajit; Liu, Steven; Morgan, Ray; Valadez, John; Moore, Bill; Burns, John

2007-10-01

Resolution limitations in the mask making process can cause differences between the features that appear in a database and those printed to a reticle. These differences may result from intentional or unintentional features in the database exceeding the resolution limit of the mask making process such as small gaps or lines in the data, line end shortening on small sub-resolution assist features etc creating challenges to both mask writing and mask inspection. Areas with high variance from design to mask, often referred to as high MEEF areas (mask error enhancement factor), become highly problematic and can directly impact mask and device yield, mask manufacturing cycle time and ultimately mask costs. Specific to mask inspection it may be desirable to inspect certain non-critical or non-relevant features at reduced sensitivity so as not to detect real, but less significant process defects. In contrast there may also be times where increased sensitivity is required for critical mask features or areas. Until recently, this process was extremely manual, creating added time and cost to the mask inspection cycle. Shifting to more intelligent and automated inspection flows is the key focus of this paper. A novel approach to importing design data directly into the mask inspection to include both MDP generated MRC errors files and LRC generated MEEF files. The results of recently developed inspection and review capability based upon controlling defect inspection using design aware data base control layers on a pixel basis are discussed. Typical mask shop applications and implementations will be shown.

Substantial Integration of Typical Educational Games into Extended Curricula

ERIC Educational Resources Information Center

Clark, Douglas B.; Tanner-Smith, Emily; Hostetler, Andrew; Fradkin, Aryah; Polikov, Vadim

2018-01-01

Much research focuses on what might be possible with digital games in the classroom. This study focuses on what is currently probable and typical. It uses a controlled quasi-experimental design to compare outcomes for students of 13 teachers in 10 diverse urban, suburban, and rural schools. The teachers integrated a set of 55 typical educational…

Aerospace Systems Design in NASA's Collaborative Engineering Environment

NASA Technical Reports Server (NTRS)

Monell, Donald W.; Piland, William M.

1999-01-01

Past designs of complex aerospace systems involved an environment consisting of collocated design teams with project managers, technical discipline experts, and other experts (e.g. manufacturing and systems operations). These experts were generally qualified only on the basis of past design experience and typically had access to a limited set of integrated analysis tools. These environments provided less than desirable design fidelity, often lead to the inability of assessing critical programmatic and technical issues (e.g., cost risk, technical impacts), and generally derived a design that was not necessarily optimized across the entire system. The continually changing, modern aerospace industry demands systems design processes that involve the best talent available (no matter where it resides) and access to the best design and analysis tools. A solution to these demands involves a design environment referred to as collaborative engineering. The collaborative engineering environment evolving within the National Aeronautics and Space Administration (NASA) is a capability that enables the Agency's engineering infrastructure to interact and use the best state-of-the-art tools and data across organizational boundaries. Using collaborative engineering, the collocated team is replaced with an interactive team structure where the team members are geographically distributed and the best engineering talent can be applied to the design effort regardless of physical location. In addition, a more efficient, higher quality design product is delivered by bringing together the best engineering talent with more up-to-date design and analysis tools. These tools are focused on interactive, multidisciplinary design and analysis with emphasis on the complete life cycle of the system, and they include nontraditional, integrated tools for life cycle cost estimation and risk assessment. NASA has made substantial progress during the last two years in developing a collaborative engineering environment. NASA is planning to use this collaborative engineering infrastructure to provide better aerospace systems life cycle design and analysis, which includes analytical assessment of the technical and programmatic aspects of a system from "cradle to grave." This paper describes the recent NASA developments in the area of collaborative engineering, the benefits (realized and anticipated) of using the developed capability, and the long-term plans for implementing this capability across the Agency.

Aerospace Systems Design in NASA's Collaborative Engineering Environment

NASA Technical Reports Server (NTRS)

Monell, Donald W.; Piland, William M.

2000-01-01

Past designs of complex aerospace systems involved an environment consisting of collocated design teams with project managers, technical discipline experts, and other experts (e.g., manufacturing and systems operation). These experts were generally qualified only on the basis of past design experience and typically had access to a limited set of integrated analysis tools. These environments provided less than desirable design fidelity, often lead to the inability of assessing critical programmatic and technical issues (e.g., cost, risk, technical impacts), and generally derived a design that was not necessarily optimized across the entire system. The continually changing, modern aerospace industry demands systems design processes that involve the best talent available (no matter where it resides) and access to the the best design and analysis tools. A solution to these demands involves a design environment referred to as collaborative engineering. The collaborative engineering environment evolving within the National Aeronautics and Space Administration (NASA) is a capability that enables the Agency's engineering infrastructure to interact and use the best state-of-the-art tools and data across organizational boundaries. Using collaborative engineering, the collocated team is replaced with an interactive team structure where the team members are geographical distributed and the best engineering talent can be applied to the design effort regardless of physical location. In addition, a more efficient, higher quality design product is delivered by bringing together the best engineering talent with more up-to-date design and analysis tools. These tools are focused on interactive, multidisciplinary design and analysis with emphasis on the complete life cycle of the system, and they include nontraditional, integrated tools for life cycle cost estimation and risk assessment. NASA has made substantial progress during the last two years in developing a collaborative engineering environment. NASA is planning to use this collaborative engineering engineering infrastructure to provide better aerospace systems life cycle design and analysis, which includes analytical assessment of the technical and programmatic aspects of a system from "cradle to grave." This paper describes the recent NASA developments in the area of collaborative engineering, the benefits (realized and anticipated) of using the developed capability, and the long-term plans for implementing this capability across Agency.

Aerospace Systems Design in NASA's Collaborative Engineering Environment

NASA Astrophysics Data System (ADS)

Monell, Donald W.; Piland, William M.

2000-07-01

Past designs of complex aerospace systems involved an environment consisting of collocated design teams with project managers, technical discipline experts, and other experts (e.g., manufacturing and systems operations). These experts were generally qualified only on the basis of past design experience and typically had access to a limited set of integrated analysis tools. These environments provided less than desirable design fidelity, often led to the inability of assessing critical programmatic and technical issues (e.g., cost, risk, technical impacts), and generally derived a design that was not necessarily optimized across the entire system. The continually changing, modern aerospace industry demands systems design processes that involve the best talent available (no matter where it resides) and access to the best design and analysis tools. A solution to these demands involves a design environment referred to as collaborative engineering. The collaborative engineering environment evolving within the National Aeronautics and Space Administration (NASA) is a capability that enables the Agency's engineering infrastructure to interact and use the best state-of-the-art tools and data across organizational boundaries. Using collaborative engineering, the collocated team is replaced with an interactive team structure where the team members are geographically distributed and the best engineering talent can be applied to the design effort regardless of physical location. In addition, a more efficient, higher quality design product is delivered by bringing together the best engineering talent with more up-to-date design and analysis tools. These tools are focused on interactive, multidisciplinary design and analysis with emphasis on the complete life cycle of the system, and they include nontraditional, integrated tools for life cycle cost estimation and risk assessment. NASA has made substantial progress during the last two years in developing a collaborative engineering environment. NASA is planning to use this collaborative engineering infrastructure to provide better aerospace systems life cycle design and analysis, which includes analytical assessment of the technical and programmatic aspects of a system from "cradle to grave." This paper describes the recent NASA developments in the area of collaborative engineering, the benefits (realized and anticipated) of using the developed capability, and the long-term plans for implementing this capability across the Agency.

Guiding Design of University STEM Courses Based on Gifted Status and Strategies for Success

NASA Astrophysics Data System (ADS)

Hawthorne Allen, A. M.

2016-12-01

Starting from general population statistics and the self-selection of STEM majors by students, it can be concluded that science classes have a population of students trending towards the gifted, regardless of academic institution and admissions selectivity. On average, upper level and graduate STEM courses have an increasingly larger fraction of gifted students. I propose that the average level of giftedness of the students within a course serves as an overriding characteristic that is more significant than other demographic variables. Using this model when designing a STEM course can lead to more successful learning outcomes. In 1991, the Columbus Group defined giftedness as "asynchronous development in which advanced cognitive abilities and heightened intensity combine to create inner experiences and awareness than are qualitatively different from the norm." These gifted characteristics are fundamentally innate lifelong traits that persist beyond K-12 designations and into our college classrooms. As this broader understanding of giftedness has emerged, myths and stereotypes in prior literature have also become clearer. Understanding and naming these myths can better impact our teaching effectiveness. While the diversity of gifted populations makes generalization difficult, gifted individuals can be described as having the following: asynchronous development, increased perceptivity, high sensitivity, perfectionism, and intensity. Several levels of giftedness have been identified on the basis of IQ scores or innate characteristics from birth. In addition, students who are twice-exceptional are yet another subpopulation present in our classes. If the average gifted level of STEM majors is higher than the norm population for a typical level of education, then understanding the characteristics of the subpopulations and the impact on classroom dynamics is essential. This directly impacts our STEM teaching pedagogy and style if productive learning outcomes are to be attained. For example, modern STEM teaching utilizes pedagogical interventions that typically involve active learning. The success of such interventions will interact with the gifted profile of students in a given class. In this presentation, I describe strategies, frameworks, and concrete examples that work for such students.

Laser System for Precise, Unambiguous Range Measurements

NASA Technical Reports Server (NTRS)

Dubovitsky, Serge; Lay, Oliver

2005-01-01

The Modulation Sideband Technology for Absolute Range (MSTAR) architecture is the basis of design of a proposed laser-based heterodyne interferometer that could measure a range (distance) as great as 100 km with a precision and resolution of the order of 1 nm. Simple optical interferometers can measure changes in range with nanometer resolution, but cannot measure range itself because interference is subject to the well-known integer-multiple-of-2 -radians phase ambiguity, which amounts to a range ambiguity of the order of 1 m at typical laser wavelengths. Existing rangefinders have a resolution of the order of 10 m and are therefore unable to resolve the ambiguity. The proposed MSTAR architecture bridges the gap, enabling nanometer resolution with an ambiguity range that can be extended to arbitrarily large distances. The MSTAR architecture combines the principle of the heterodyne interferometer with the principle of extending the ambiguity range of an interferometer by using light of two wavelengths. The use of two wavelengths for this purpose is well established in optical metrology, radar, and sonar. However, unlike in traditional two-color laser interferometry, light of two wavelengths would not be generated by two lasers. Instead, multiple wavelengths would be generated as sidebands of phase modulation of the light from a single frequency- stabilized laser. The phase modulation would be effected by applying sinusoidal signals of suitable frequencies (typically tens of gigahertz) to high-speed electro-optical phase modulators. Intensity modulation can also be used

Single-step direct fabrication of pillar-on-pore hybrid nanostructures in anodizing aluminum for superior superhydrophobic efficiency.

PubMed

Jeong, Chanyoung; Choi, Chang-Hwan

2012-02-01

Conventional electrochemical anodizing processes of metals such as aluminum typically produce planar and homogeneous nanopore structures. If hydrophobically treated, such 2D planar and interconnected pore structures typically result in lower contact angle and larger contact angle hysteresis than 3D disconnected pillar structures and, hence, exhibit inferior superhydrophobic efficiency. In this study, we demonstrate for the first time that the anodizing parameters can be engineered to design novel pillar-on-pore (POP) hybrid nanostructures directly in a simple one-step fabrication process so that superior surface superhydrophobicity can also be realized effectively from the electrochemical anodization process. On the basis of the characteristic of forming a self-ordered porous morphology in a hexagonal array, the modulation of anodizing voltage and duration enabled the formulation of the hybrid-type nanostructures having controlled pillar morphology on top of a porous layer in both mild and hard anodization modes. The hybrid nanostructures of the anodized metal oxide layer initially enhanced the surface hydrophilicity significantly (i.e., superhydrophilic). However, after a hydrophobic monolayer coating, such hybrid nanostructures then showed superior superhydrophobic nonwetting properties not attainable by the plain nanoporous surfaces produced by conventional anodization conditions. The well-regulated anodization process suggests that electrochemical anodizing can expand its usefulness and efficacy to render various metallic substrates with great superhydrophilicity or -hydrophobicity by directly realizing pillar-like structures on top of a self-ordered nanoporous array through a simple one-step fabrication procedure.

Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls.

PubMed

Wang, Yingying; Mauer, Meaghan V; Raney, Talia; Peysakhovich, Barbara; Becker, Bryce L C; Sliva, Danielle D; Gaab, Nadine

2017-04-01

Developmental dyslexia is a neurodevelopmental disorder with a strong genetic basis. Previous studies observed white matter alterations in the left posterior brain regions in adults and school-age children with dyslexia. However, no study yet has examined the development of tract-specific white matter pathways from the pre-reading to the fluent reading stage in children at familial risk for dyslexia (FHD+) versus controls (FHD-). This study examined white matter integrity at pre-reading, beginning, and fluent reading stages cross-sectionally ( n = 78) and longitudinally (n = 45) using an automated fiber-tract quantification method. Our findings depict white matter alterations and atypical lateralization of the arcuate fasciculus at the pre-reading stage in FHD+ versus FHD- children. Moreover, we demonstrate faster white matter development in subsequent good versus poor readers and a positive association between white matter maturation and reading development using a longitudinal design. Additionally, the combination of white matter maturation, familial risk, and psychometric measures best predicted later reading abilities. Furthermore, within FHD+ children, subsequent good readers exhibited faster white matter development in the right superior longitudinal fasciculus compared with subsequent poor readers, suggesting a compensatory mechanism. Overall, our findings highlight the importance of white matter pathway maturation in the development of typical and atypical reading skills. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Canister Storage Building (CSB) Design Basis Accident Analysis Documentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

CROWE, R.D.; PIEPHO, M.G.

2000-03-23

This document provided the detailed accident analysis to support HNF-3553, Spent Nuclear Fuel Project Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report''. All assumptions, parameters, and models used to provide the analysis of the design basis accidents are documented to support the conclusions in the Canister Storage Building Final Safety Analysis Report.

7 CFR 54.1005 - Basis of service.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false Basis of service. 54.1005 Section 54.1005 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... and Poultry Products § 54.1005 Basis of service. (a) Certification of Sanitary Design and Fabrication...

7 CFR 54.1005 - Basis of service.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false Basis of service. 54.1005 Section 54.1005 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... and Poultry Products § 54.1005 Basis of service. (a) Certification of Sanitary Design and Fabrication...

Technical Basis for Water Chemistry Control of IGSCC in Boiling Water Reactors

NASA Astrophysics Data System (ADS)

Gordon, Barry; Garcia, Susan

Boiling water reactors (BWRs) operate with very high purity water. However, even the utilization of near theoretical conductivity water cannot prevent intergranular stress corrosion cracking (IGSCC) of sensitized stainless steel, wrought nickel alloys and nickel weld metals under oxygenated conditions. IGSCC can be further accelerated by the presence of certain impurities dissolved in the coolant. The goal of this paper is to present the technical basis for controlling various impurities under both oxygenated, i.e., normal water chemistry (NWC) and deoxygenated, i.e., hydrogen water chemistry (HWC) conditions for mitigation of IGSCC. More specifically, the effects of typical BWR ionic impurities (e.g., sulfate, chloride, nitrate, borate, phosphate, etc.) on IGSCC propensities in both NWC and HWC environments will be discussed. The technical basis for zinc addition to the BWR coolant will also provided along with an in-plant example of the most severe water chemistry transient to date.

Design considerations for near-infrared filter photometry: effects of noise sources and selectivity.

PubMed

Tarumi, Toshiyasu; Amerov, Airat K; Arnold, Mark A; Small, Gary W

2009-06-01

Optimal filter design of two-channel near-infrared filter photometers is investigated for simulated two-component systems consisting of an analyte and a spectrally overlapping interferent. The degree of overlap between the analyte and interferent bands is varied over three levels. The optimal design is obtained for three cases: a source or background flicker noise limited case, a shot noise limited case, and a detector noise limited case. Conventional photometers consist of narrow-band optical filters with their bands located at discrete wavelengths. However, the use of broadband optical filters with overlapping responses has been proposed to obtain as much signal as possible from a weak and broad analyte band typical of near-infrared absorptions. One question regarding the use of broadband optical filters with overlapping responses is the selectivity achieved by such filters. The selectivity of two-channel photometers is evaluated on the basis of the angle between the analyte and interferent vectors in the space spanned by the relative change recorded for each of the two detector channels. This study shows that for the shot noise limited or detector noise limited cases, the slight decrease in selectivity with the use of broadband optical filters can be compensated by the higher signal-to-noise ratio afforded by the use of such filters. For the source noise limited case, the best quantitative results are obtained with the use of narrow-band non-overlapping optical filters.

Concept Test of a Smoking Cessation Smart Case.

PubMed

Comello, Maria Leonora G; Porter, Jeannette H

2018-04-05

Wearable/portable devices that unobtrusively detect smoking and contextual data offer the potential to provide Just-In-Time Adaptive Intervention (JITAI) support for mobile cessation programs. Little has been reported on the development of these technologies. To address this gap, we offer a case report of users' experiences with a prototype "smart" cigarette case that automatically tracks time and location of smoking. Small-scale user-experience studies are typical of iterative product design and are especially helpful when proposing novel ideas. The purpose of the study was to assess concept acceptability and potential for further development. We tested the prototype case with a small sample of potential users (n = 7). Participants used the hardware/software for 2 weeks and reconvened for a 90-min focus group to discuss experiences and provide feedback. Participants liked the smart case in principle but found the prototype too bulky for easy portability. The potential for the case to convey positive messages about self also emerged as a finding. Participants indicated willingness to pay for improved technology (USD $15-$60 on a one-time basis). The smart case is a viable concept, but design detail is critical to user acceptance. Future research should examine designs that maximize convenience and that explore the device's ability to cue intentions and other cognitions that would support cessation. This study is the first to our knowledge to report formative research on the smart case concept. This initial exploration provides insights that may be helpful to other developers of JITAI-support technology.

Testing the bi-dimensional effects of attitudes on behavioural intentions and subsequent behaviour.

PubMed

Elliott, Mark A; Brewster, Sarah E; Thomson, James A; Malcolm, Carly; Rasmussen, Susan

2015-11-01

Attitudes are typically treated as unidimensional predictors of both behavioural intentions and subsequent behaviour. On the basis of previous research showing that attitudes comprise two independent, positive and negative dimensions, we hypothesized that attitudes would be bi-dimensional predictors of both behavioural intentions and subsequent behaviour. We focused on health-risk behaviours. We therefore also hypothesized that the positive dimension of attitude (evaluations of positive behavioural outcomes) would better predict both behavioural intentions and subsequent behaviour than would the negative dimension, consistent with the positivity bias/offset principle. In Study 1 (cross sectional design), N = 109 university students completed questionnaire measures of their intentions to binge-drink and the positive and negative dimensions of attitude. Consistent with the hypotheses, both attitude dimensions independently predicted behavioural intentions and the positive dimension was a significantly better predictor than was the negative dimension. The same pattern of findings emerged in Study 2 (cross sectional design; N = 186 university students) when we predicted intentions to binge-drink, smoke and consume a high-fat diet. Similarly, in Study 3 (prospective design; N = 1,232 speed limit offenders), both the positive and negative dimensions of attitude predicted subsequent (6-month post-baseline) speeding behaviour on two different road types and the positive dimension was the better predictor. The implications for understanding the motivation of behaviour and the development of behaviour-change interventions are discussed. © 2014 The British Psychological Society.

Lyme disease: review.

PubMed

Biesiada, Grażyna; Czepiel, Jacek; Leśniak, Maciej R; Garlicki, Aleksander; Mach, Tomasz

2012-12-20

Lyme disease is a multi-organ animal-borne disease, caused by spirochetes of Borrelia burgdorferi (Bb), which typically affect the skin, nervous system, musculoskeletal system and heart. A history of confirmed exposure to tick bites, typical signs and symptoms of Lyme borreliosis and positive tests for anti-Bb antibodies, are the basis of a diagnosis. A two-step diagnosis is necessary: the first step is based on a high sensitivity ELISA test with positive results confirmed by a more specific Western blot assay. Antibiotic therapy is curative in most cases, but some patients develop chronic symptoms, which do not respond to antibiotics. The aim of this review is to summarize our current knowledge of the symptoms, clinical diagnosis and treatment of Lyme borreliosis.

Gait functional assessment: Spatio-temporal analysis and classification of barefoot plantar pressure in a group of 11-12-year-old children.

PubMed

Latour, Ewa; Latour, Marek; Arlet, Jarosław; Adach, Zdzisław; Bohatyrewicz, Andrzej

2011-07-01

Analysis of pedobarographical data requires geometric identification of specific anatomical areas extracted from recorded plantar pressures. This approach has led to ambiguity in measurements that may underlie the inconsistency of conclusions reported in pedobarographical studies. The goal of this study was to design a new analysis method less susceptible to the projection accuracy of anthropometric points and distance estimation, based on rarely used spatio-temporal indices. Six pedobarographic records per person (three per foot) from a group of 60 children aged 11-12 years were obtained and analyzed. The basis of the analysis was a mutual relationship between two spatio-temporal indices created by excursion of the peak pressure point and the center-of-pressure point on the dynamic pedobarogram. Classification of weight-shift patterns was elaborated and performed, and their frequencies of occurrence were assessed. This new method allows an assessment of body weight shift through the plantar pressure surface based on distribution analysis of spatio-temporal indices not affected by the shape of this surface. Analysis of the distribution of the created index confirmed the existence of typical ways of weight shifting through the plantar surface of the foot during gait, as well as large variability of the intrasubject occurrence. This method may serve as the basis for interpretation of foot functional features and may extend the clinical usefulness of pedobarography. Copyright © 2011 Elsevier B.V. All rights reserved.

Some Implications of the Three Mile Island Accident for LMFBR Safety and Licensing: The Design Basis Issue

DTIC Science & Technology

1980-08-01

metal fast breeder reactor (LMFBR) design. It also re-examines the impact of the accident at Three Mile Island on the design basis concept, and how...Water Reactors : ImpZications for Liquid MetaZ Fast Breeder Reactors , by W. E. Kastenberg and K. A. Solomon, July 1979. v SUNMARY The 1979 accident...the liquid metal fast breeder reactor (LMFBR). This Note assesses the impact of the TMI-2 accident on the LMFBR. Specifically, it: o Reviews the

Application of GA package in functional packaging

NASA Astrophysics Data System (ADS)

Belousova, D. A.; Noskova, E. E.; Kapulin, D. V.

2018-05-01

The approach to application program for the task of configuration of the elements of the commutation circuit for design of the radio-electronic equipment on the basis of the genetic algorithm is offered. The efficiency of the used approach for commutation circuits with different characteristics for computer-aided design on radio-electronic manufacturing is shown. The prototype of the computer-aided design subsystem on the basis of a package GA for R with a set of the general functions for optimization of multivariate models is programmed.

Universal Design: Process, Principles, and Applications

ERIC Educational Resources Information Center

Burgstahler, Sheryl

2009-01-01

Designing any product or environment involves the consideration of many factors, including aesthetics, engineering options, environmental issues, safety concerns, industry standards, and cost. Typically, designers focus their attention on the average user. In contrast, universal design (UD), according to the Center for Universal Design," is…

Relaxed Manufacturing Design Tolerance Concepts. Volume 2. Appendices

DTIC Science & Technology

1977-07-01

are typical for such a part. A rough and finish pass is made to web thickness, a rough cut is made in the corners and then the stlf- fener walls...the programmed teed rate a little more on the second side due to having less material behind the web ; however, a designer usually provides for...Typical Survov Data Rocord Recommended Relaxation on Drawing Tolerances for Webs and Stiffcners Web Dimensional Deviation Occurrences vs. Stiffener

A Controlled Study of Mercury Levels in Hair Samples of Children with Autism as Compared to Their Typically Developing Siblings

ERIC Educational Resources Information Center

Williams, P. Gail; Hersh, Joseph H.; Allard, AnnaMary; Sears, Lonnie L.

2008-01-01

Autism is a developmental disability characterized by severe, pervasive deficits in social interaction, communication and range of interests and activities. The neurobiologic basis of autism is well accepted, although the specific etiology is unknown. It has been theorized that autism may result from a combination of predisposing genes and…

The Use of Motion Tracking Technologies in Serious Games to Enhance Rehabilitation in Stroke Patients

ERIC Educational Resources Information Center

Burton, Andrew M.; Liu, Hao; Battersby, Steven; Brown, David; Sherkat, Nasser; Standen, Penny; Walker, Marion

2011-01-01

Stroke is the main cause of long term disability worldwide. Of those surviving, more than half will fail to regain functional usage of their impaired upper limb. Typically stroke upper limb rehabilitation exercises consist of repeated movements, which when tracked can form the basis of inputs to games. This paper discusses two systems utilizing…

Virus-induced gene silencing and transient gene expression in soybean using Bean pod mottle virus infectious clones

USDA-ARS?s Scientific Manuscript database

Virus-induced gene silencing (VIGS) is a powerful and rapid approach for determining the functions of plant genes. The basis of VIGS is that a viral genome is engineered so that it can carry fragments of plant genes, typically in the 200-300 base pair size range. The recombinant viruses are used to ...

Time to Reclassification: How Long Does It Take English Language Learners in Seven Washington Districts to Develop English Proficiency?

ERIC Educational Resources Information Center

Motamedi, Jason Greenberg

2016-01-01

This study provides a basis for understanding how long it typically takes English language learners (ELLs) in seven Washington school districts to achieve reclassification as former ELLs. Researchers looked at ELLs' grade level and English proficiency at school entry, as well as their gender, home language, race/ethnicity, special education…

The Bridge: A Journal of Cross-Cultural Affairs; Summer 1976, Volume 1, Number 2.

ERIC Educational Resources Information Center

Reynolds, Collins, Ed.

This quarterly newsletter, announced in RIE on a one-time basis, investigates a different area of the world in each issue. It is intended for use by businessmen, government officials, and educators. Typical issues include feature articles highlighting problems of crossing cultural boundaries to teach, do business, or cope overseas and at home;…

Understanding the Molecular Basis of Psoriasis | Center for Cancer Research

Cancer.gov

Unsightly red patches, itchy, flaky skin, and disfigured nails are typical symptoms of psoriasis, one of the most common chronic inflammatory diseases of the skin. An estimated 7.5 million people in the United States are affected. The disease is characterized by increased production of skin cells and inflammation in the skin, but it is unclear if the primary trigger is

Maintaining the Access Mission: Open Access Universities and the Challenges of Performance-Based Funding

ERIC Educational Resources Information Center

Mathuews, Katy; Pulcini, Brad

2017-01-01

For the purposes of this article, open access universities are defined as bachelor's degree-granting institutions that do not restrict admission on the basis of ACT/SAT scores, high school grade point average, and the like. Typically, the mission of an open access university is to provide all students with the opportunity to pursue a degree. The…

An evaluation of the basis and consequences of a stay-green mutation in the navel negra (nan) citrus mutant using transcriptomic and proteomic profiling and metabolite analysis

USDA-ARS?s Scientific Manuscript database

A Citrus sinensis spontaneous mutant, navel negra (nan), produces fruit with an abnormal brown colored flavedo during ripening. Analysis of pigment composition in the wild type (WT) and nan flavedo suggested that typical ripening-related chlorophyll (Chl) degradation, but not carotenoid biosynthesis...

Neuroimaging of the Functional and Structural Networks Underlying Visuospatial vs. Linguistic Reasoning in High-Functioning Autism

ERIC Educational Resources Information Center

Sahyoun, Cherif P.; Belliveau, John W.; Soulieres, Isabelle; Schwartz, Shira; Mody, Maria

2010-01-01

High-functioning individuals with autism have been found to favor visuospatial processing in the face of typically poor language abilities. We aimed to examine the neurobiological basis of this difference using functional magnetic resonance imaging and diffusion tensor imaging. We compared 12 children with high functioning autism (HFA) to 12 age-…

Job Realities of Primary School Principals in Greece: Similarities and Variations in a Highly Centralized System

ERIC Educational Resources Information Center

Dimopoulos, Kostas; Dalkavouki, Katerina; Koulaidis, Vasilis

2015-01-01

This study aims at investigating primary school principals' work on a daily basis in order to understand the ways in which the centralized educational system affects their practices. Four typical cases of principals were selected and asked to keep daily records for a period of four months. Data from logs were complemented with data collected…

Students' Conceptions about "Radiation": Results from an Explorative Interview Study of 9th Grade Students

ERIC Educational Resources Information Center

Neumann, Susanne; Hopf, Martin

2012-01-01

One basis of good teaching is to know about your students' preconceptions. Studies about typical ideas that students bring to the science classroom have been and continue to be a major field in science education research. This study aims to explore associations and ideas that students have regarding "radiation", a term widely used in…

Vibrations in a moving flexible robot arm

NASA Technical Reports Server (NTRS)

Wang, P. K. C.; Wei, Jin-Duo

1987-01-01

The vibration in a flexible robot arm modeled by a moving slender prismatic beam is considered. It is found that the extending and contracting motions have destabilizing and stabilizing effects on the vibratory motions, respectively. The vibration analysis is based on a Galerkin approximation with time-dependent basis functions. Typical numerical results are presented to illustrate the qualitative features of vibrations.

Young Children's Use of Video as a Source of Socially Relevant Information

ERIC Educational Resources Information Center

Troseth, Georgene L.; Saylor, Megan M.; Archer, Allison H.

2006-01-01

Although prior research clearly shows that toddlers have difficulty learning from video, the basis for their difficulty is unknown. In the 2 current experiments, the effect of social feedback on 2-year-olds' use of information from video was assessed. Children who were told "face to face" where to find a hidden toy typically found it, but children…

A Slag Management Toolset for Determining Optimal Coal Gasification Temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwong, Kyei-Sing; Bennett, James P.

Abstract Gasifier operation is an intricate process because of the complex relationship between slag chemistry and temperature, limitations of feedstock materials, and operational preference. High gasification temperatures increase refractory degradation, while low gasification temperatures can lead to slag buildup on the gasifier sidewall or exit, either of which are problematic during operation. Maximizing refractory service life and gasifier performance require finding an optimized operating temperature range which is a function of the coal slag chemistry and viscosity. Gasifier operators typically use a slag’s viscosity-temperature relationship and/or ash-fusion fluid temperature to determine the gasification temperature range. NETL has built a slagmore » management toolset to determine the optimal temperature range for gasification of a carbon feedstock. This toolset is based on a viscosity database containing experimental data, and a number of models used to predict slag viscosity as a function of composition and temperature. Gasifier users typically have no scientific basis for selecting an operational temperature range for gasification, instead using experience to select operational conditions. The use of the toolset presented in this paper provides a basis for estimating or modifying carbon feedstock slags generated from ash impurities in carbon feedstock.« less

Vestibular responses to loud dance music: a physiological basis of the "rock and roll threshold"?

PubMed

Todd, N P; Cody, F W

2000-01-01

In this paper new evidence is provided to indicate that vestibular responses may be obtained from loud dance music for intensities above 90 dB(A) SPL (Impulse-weighted). In a sample of ten subjects acoustically evoked EMG were obtained from the sternocleidomastoid muscle in response to a sample of techno music typical of that which may be experienced in a dance club. Previous research has shown that this response is vestibularly mediated since it can be obtained in subjects with loss of cochlear function, but is absent in subjects with loss of vestibular function (Colebatch et al. [J. Neurol. Neurosurg. Psychiatr. 57, 190-197 (1994)]. Given that pleasurable sensations of self-motion are widely sought after by more normal means of vestibular stimulation, it is suggested that acoustically evoked sensations of self-motion may account for the compulsion to exposure to loud music. Given further the similarity between the thresholds found, and the intensities and frequency distributions that are typical in rock concerts and dance clubs, it is also suggested that this response may be a physiological basis for the minimum loudness necessary for rock and dance music to work-the "rock and roll threshold".

A Slag Management Toolset for Determining Optimal Coal Gasification Temperatures

DOE PAGES

Kwong, Kyei-Sing; Bennett, James P.

2016-11-25

Abstract Gasifier operation is an intricate process because of the complex relationship between slag chemistry and temperature, limitations of feedstock materials, and operational preference. High gasification temperatures increase refractory degradation, while low gasification temperatures can lead to slag buildup on the gasifier sidewall or exit, either of which are problematic during operation. Maximizing refractory service life and gasifier performance require finding an optimized operating temperature range which is a function of the coal slag chemistry and viscosity. Gasifier operators typically use a slag’s viscosity-temperature relationship and/or ash-fusion fluid temperature to determine the gasification temperature range. NETL has built a slagmore » management toolset to determine the optimal temperature range for gasification of a carbon feedstock. This toolset is based on a viscosity database containing experimental data, and a number of models used to predict slag viscosity as a function of composition and temperature. Gasifier users typically have no scientific basis for selecting an operational temperature range for gasification, instead using experience to select operational conditions. The use of the toolset presented in this paper provides a basis for estimating or modifying carbon feedstock slags generated from ash impurities in carbon feedstock.« less

Effect of Aerodynamic Design on Glider Performance

NASA Technical Reports Server (NTRS)

Lippisch, A

1935-01-01

The performance of a glider is determined by means of the velocity polar, which represents the connection between horizontal and sinking speed. The mean sinking speed for a given speed range can be determined on the basis of the velocity polar. These data form the basis for the most propitious design of a performance-type glider with a view to long-distance flight.

Effect of moisture on typical Virginia surface treatment materials.

DOT National Transportation Integrated Search

1970-01-01

Several aspects of the stripping and whip off characteristics of typical Virginia surface treatment materials were investigated. Sixty different binder-aggregate combinations were tested with the AASHO Designation T182-57 stripping test, a plate imme...

Development and use of computational techniques in Army Aviation research and development programs for crash resistant helicopter technology

NASA Technical Reports Server (NTRS)

Burrows, Leroy T.

1993-01-01

During the 1960's over 30 full-scale aircraft crash tests were conducted by the Flight Safety Foundation under contract to the Aviation Applied Technology Directorate (AATD) of the U.S. Army Aviation Systems Command (AVSCOM). The purpose of these tests were to conduct crash injury investigations that would provide a basis for the formulation of sound crash resistance design criteria for light fixed-wing and rotary wing aircraft. This resulted in the Crash Survival Design Criteria Designer's Guide which was first published in 1967 and has been revised numerous times, the last being in 1989. Full-scale aircraft crash testing is an expensive way to investigate structural deformations of occupied spaces and to determine the decelerative loadings experienced by occupants in a crash. This gave initial impetus to the U.S. Army to develop analytical methods to predict the dynamic response of aircraft structures in a crash. It was believed that such analytical tools could be very useful in the preliminary design stage of a new helicopter system which is required to demonstrate a level of crash resistance and had to be more cost effective than full-scale crash tests or numerous component design support tests. From an economic point of view, it is more efficient to optimize for the incorporation of crash resistance features early in the design stage. However, during preliminary design it is doubtful if sufficient design details, which influence the exact plastic deformation shape of structural elements, will be available. The availability of simple procedures to predict energy absorption and load-deformation characteristics will allow the designer to initiate valuable cost, weight, and geometry tradeoff studies. The development of these procedures will require some testing of typical specimens. This testing should, as a minimum, verify the validity of proposed procedures for providing pertinent nonlinear load-deformation data. It was hoped that through the use of these analytical models, the designer could optimize aircraft design for crash resistance from both a weight and cost increment standpoint, thus enhancing the acceptance of the design criteria for crash resistance.

Recent developments in the structural design and optimization of ITER neutral beam manifold

NASA Astrophysics Data System (ADS)

Chengzhi, CAO; Yudong, PAN; Zhiwei, XIA; Bo, LI; Tao, JIANG; Wei, LI

2018-02-01

This paper describes a new design of the neutral beam manifold based on a more optimized support system. A proposed alternative scheme has presented to replace the former complex manifold supports and internal pipe supports in the final design phase. Both the structural reliability and feasibility were confirmed with detailed analyses. Comparative analyses between two typical types of manifold support scheme were performed. All relevant results of mechanical analyses for typical operation scenarios and fault conditions are presented. Future optimization activities are described, which will give useful information for a refined setting of components in the next phase.

Radial Basis Function Neural Network Application to Power System Restoration Studies

PubMed Central

Sadeghkhani, Iman; Ketabi, Abbas; Feuillet, Rene

2012-01-01

One of the most important issues in power system restoration is overvoltages caused by transformer switching. These overvoltages might damage some equipment and delay power system restoration. This paper presents a radial basis function neural network (RBFNN) to study transformer switching overvoltages. To achieve good generalization capability for developed RBFNN, equivalent parameters of the network are added to RBFNN inputs. The developed RBFNN is trained with the worst-case scenario of switching angle and remanent flux and tested for typical cases. The simulated results for a partial of 39-bus New England test system show that the proposed technique can estimate the peak values and duration of switching overvoltages with good accuracy. PMID:22792093

Coronavirus 229E-related pneumonia in immunocompromised patients.

PubMed

Pene, Frédéric; Merlat, Annabelle; Vabret, Astrid; Rozenberg, Flore; Buzyn, Agnès; Dreyfus, François; Cariou, Alain; Freymuth, François; Lebon, Pierre

2003-10-01

Coronaviruses strains 229E and OC43 have been associated with various respiratory illnesses ranging from the self-resolving common cold to severe pneumonia. Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocompromised patients are available. Here we report 2 well-documented cases of pneumonia related to coronavirus 229E, each with a different clinical presentation. Diagnosis was made on the basis of viral culture and electron microscopy findings that exhibited typical crown-like particles and through amplification of the viral genome by reverse transcriptase-polymerase chain reaction. On the basis of this report, coronaviruses should be considered as potential causative microorganisms of pneumonia in immunocompromised patients.

Dictionary Approaches to Image Compression and Reconstruction

NASA Technical Reports Server (NTRS)

Ziyad, Nigel A.; Gilmore, Erwin T.; Chouikha, Mohamed F.

1998-01-01

This paper proposes using a collection of parameterized waveforms, known as a dictionary, for the purpose of medical image compression. These waveforms, denoted as phi(sub gamma), are discrete time signals, where gamma represents the dictionary index. A dictionary with a collection of these waveforms is typically complete or overcomplete. Given such a dictionary, the goal is to obtain a representation image based on the dictionary. We examine the effectiveness of applying Basis Pursuit (BP), Best Orthogonal Basis (BOB), Matching Pursuits (MP), and the Method of Frames (MOF) methods for the compression of digitized radiological images with a wavelet-packet dictionary. The performance of these algorithms is studied for medical images with and without additive noise.

Dictionary Approaches to Image Compression and Reconstruction

NASA Technical Reports Server (NTRS)

Ziyad, Nigel A.; Gilmore, Erwin T.; Chouikha, Mohamed F.

1998-01-01

This paper proposes using a collection of parameterized waveforms, known as a dictionary, for the purpose of medical image compression. These waveforms, denoted as lambda, are discrete time signals, where y represents the dictionary index. A dictionary with a collection of these waveforms Is typically complete or over complete. Given such a dictionary, the goal is to obtain a representation Image based on the dictionary. We examine the effectiveness of applying Basis Pursuit (BP), Best Orthogonal Basis (BOB), Matching Pursuits (MP), and the Method of Frames (MOF) methods for the compression of digitized radiological images with a wavelet-packet dictionary. The performance of these algorithms is studied for medical images with and without additive noise.

Hierarchical representation and machine learning from faulty jet engine behavioral examples to detect real time abnormal conditions

NASA Technical Reports Server (NTRS)

Gupta, U. K.; Ali, M.

1988-01-01

The theoretical basis and operation of LEBEX, a machine-learning system for jet-engine performance monitoring, are described. The behavior of the engine is modeled in terms of four parameters (the rotational speeds of the high- and low-speed sections and the exhaust and combustion temperatures), and parameter variations indicating malfunction are transformed into structural representations involving instances and events. LEBEX extracts descriptors from a set of training data on normal and faulty engines, represents them hierarchically in a knowledge base, and uses them to diagnose and predict faults on a real-time basis. Diagrams of the system architecture and printouts of typical results are shown.

Confined One Dimensional Harmonic Oscillator as a Two-Mode System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gueorguiev, V G; Rau, A P; Draayer, J P

2005-07-11

The one-dimensional harmonic oscillator in a box problem is possibly the simplest example of a two-mode system. This system has two exactly solvable limits, the harmonic oscillator and a particle in a (one-dimensional) box. Each of the two limits has a characteristic spectral structure describing the two different excitation modes of the system. Near each of these limits, one can use perturbation theory to achieve an accurate description of the eigenstates. Away from the exact limits, however, one has to carry out a matrix diagonalization because the basis-state mixing that occurs is typically too large to be reproduced in anymore » other way. An alternative to casting the problem in terms of one or the other basis set consists of using an ''oblique'' basis that uses both sets. Through a study of this alternative in this one-dimensional problem, we are able to illustrate practical solutions and infer the applicability of the concept for more complex systems, such as in the study of complex nuclei where oblique-basis calculations have been successful.« less

Risk Evaluation in the Pre-Phase A Conceptual Design of Spacecraft

NASA Technical Reports Server (NTRS)

Fabisinski, Leo L., III; Maples, Charlotte Dauphne

2010-01-01

Typically, the most important decisions in the design of a spacecraft are made in the earliest stages of its conceptual design the Pre-Phase A stages. It is in these stages that the greatest number of design alternatives is considered, and the greatest number of alternatives is rejected. The focus of Pre-Phase A conceptual development is on the evaluation and comparison of whole concepts and the larger-scale systems comprising those concepts. This comparison typically uses general Figures of Merit (FOMs) to quantify the comparative benefits of designs and alternative design features. Along with mass, performance, and cost, risk should be one of the major FOMs in evaluating design decisions during the conceptual design phases. However, risk is often given inadequate consideration in conceptual design practice. The reasons frequently given for this lack of attention to risk include: inadequate mission definition, lack of rigorous design requirements in early concept phases, lack of fidelity in risk assessment methods, and under-evaluation of risk as a viable FOM for design evaluation. In this paper, the role of risk evaluation in early conceptual design is discussed. The various requirements of a viable risk evaluation tool at the Pre-Phase A level are considered in light of the needs of a typical spacecraft design study. A technique for risk identification and evaluation is presented. The application of the risk identification and evaluation approach to the conceptual design process is discussed. Finally, a computational tool for risk profiling is presented and applied to assess the risk for an existing Pre-Phase A proposal. The resulting profile is compared to the risks identified for the proposal by other means.

Analysis and comparison of wrist splint designs using the finite element method: Multi-material three-dimensional printing compared to typical existing practice with thermoplastics.

PubMed

Cazon, Aitor; Kelly, Sarah; Paterson, Abby M; Bibb, Richard J; Campbell, R Ian

2017-09-01

Rheumatoid arthritis is a chronic disease affecting the joints. Treatment can include immobilisation of the affected joint with a custom-fitting splint, which is typically fabricated by hand from low temperature thermoplastic, but the approach poses several limitations. This study focused on the evaluation, by finite element analysis, of additive manufacturing techniques for wrist splints in order to improve upon the typical splinting approach. An additive manufactured/3D printed splint, specifically designed to be built using Objet Connex multi-material technology and a virtual model of a typical splint, digitised from a real patient-specific splint using three-dimensional scanning, were modelled in computer-aided design software. Forty finite element analysis simulations were performed in flexion-extension and radial-ulnar wrist movements to compare the displacements and the stresses. Simulations have shown that for low severity loads, the additive manufacturing splint has 25%, 76% and 27% less displacement in the main loading direction than the typical splint in flexion, extension and radial, respectively, while ulnar values were 75% lower in the traditional splint. For higher severity loads, the flexion and extension movements resulted in deflections that were 24% and 60%, respectively, lower in the additive manufacturing splint. However, for higher severity loading, the radial defection values were very similar in both splints and ulnar movement deflection was higher in the additive manufacturing splint. A physical prototype of the additive manufacturing splint was also manufactured and was tested under normal conditions to validate the finite element analysis data. Results from static tests showed maximum displacements of 3.46, 0.97, 3.53 and 2.51 mm flexion, extension, radial and ulnar directions, respectively. According to these results, the present research argues that from a technical point of view, the additive manufacturing splint design stands at the same or even better level of performance in displacements and stress values in comparison to the typical low temperature thermoplastic approach and is therefore a feasible approach to splint design and manufacture.

Architecture, Design, Implementatio

DTIC Science & Technology

2003-05-01

The terms architecture , design , and implementation are typically used informally in partitioning software specifications into three coarse strata of...we formalize the Intension and the Locality criteria, which imply that the distinction between architecture , design , and implementation is

Optimization of Turbine Blade Design for Reusable Launch Vehicles

NASA Technical Reports Server (NTRS)

Shyy, Wei

1998-01-01

To facilitate design optimization of turbine blade shape for reusable launching vehicles, appropriate techniques need to be developed to process and estimate the characteristics of the design variables and the response of the output with respect to the variations of the design variables. The purpose of this report is to offer insight into developing appropriate techniques for supporting such design and optimization needs. Neural network and polynomial-based techniques are applied to process aerodynamic data obtained from computational simulations for flows around a two-dimensional airfoil and a generic three- dimensional wing/blade. For the two-dimensional airfoil, a two-layered radial-basis network is designed and trained. The performances of two different design functions for radial-basis networks, one based on the accuracy requirement, whereas the other one based on the limit on the network size. While the number of neurons needed to satisfactorily reproduce the information depends on the size of the data, the neural network technique is shown to be more accurate for large data set (up to 765 simulations have been used) than the polynomial-based response surface method. For the three-dimensional wing/blade case, smaller aerodynamic data sets (between 9 to 25 simulations) are considered, and both the neural network and the polynomial-based response surface techniques improve their performance as the data size increases. It is found while the relative performance of two different network types, a radial-basis network and a back-propagation network, depends on the number of input data, the number of iterations required for radial-basis network is less than that for the back-propagation network.

Parametric Studies Of Lightweight Reflectors Supported On Linear Actuator Arrays

NASA Astrophysics Data System (ADS)

Seibert, George E.

1987-10-01

This paper presents the results of numerous design studies carried out at Perkin-Elmer in support of the design of large diameter controllable mirrors for use in laser beam control, surveillance, and astronomy programs. The results include relationships between actuator location and spacing and the associated degree of correctability attainable for a variety of faceplate configurations subjected to typical disturbance environments. Normalizations and design curves obtained from closed-form equations based on thin shallow shell theory and computer based finite-element analyses are presented for use in preliminary design estimates of actuator count, faceplate structural properties, system performance prediction and weight assessments. The results of the analyses were obtained from a very wide range of mirror configurations, including both continuous and segmented mirror geometries. Typically, the designs consisted of a thin facesheet controlled by point force actuators which in turn were mounted on a structurally efficient base panel, or "reaction structure". The faceplate materials considered were fused silica, ULE fused silica, Zerodur, aluminum and beryllium. Thin solid faceplates as well as rib-reinforced cross-sections were treated, with a wide variation in thickness and/or rib patterns. The magnitude and spatial frequency distribution of the residual or uncorrected errors were related to the input error functions for mirrors of many different diameters and focal ratios. The error functions include simple sphere-to-sphere corrections, "parabolization" of spheres, and higher spatial frequency input error maps ranging from 0.5 to 7.5 cycles per diameter. The parameter which dominates all of the results obtained to date, is a structural descriptor of thin shell behavior called the characteristic length. This parameter is a function of the shell's radius of curvature, thickness, and Poisson's ratio of the material used. The value of this constant, in itself, describes the extent to which the deflection under a point force is localized by the shell's curvature. The deflection shape is typically a near-gaussian "bump" with a zero-crossing at a local radius of approximately 3.5 characteristic lengths. The amplitude is a function of the shells elastic modulus, radius, and thickness, and is linearly proportional to the applied force. This basic shell behavior is well-treated in an excellent set of papers by Eric Reissner entitled "Stresses and Small Displacements of Shallow Spherical Shells".1'2 Building on the insight offered by these papers, we developed our design tools around two derived parameters, the ratio of the mirror's diameter to its characteristic length (D/l), and the ratio of the actuator spacing to the characteristic length (b/l). The D/1 ratio determines the "finiteness" of the shell, or its dependence on edge boundary conditions. For D/1 values greater than 10, the influence of edges is almost totally absent on interior behavior. The b/1 ratio, the basis of all our normalizations is the most universal term in the description of correctability or ratio of residual/input errors. The data presented in the paper, shows that the rms residual error divided by the peak amplitude of the input error function is related to the actuator spacing to characteristic length ratio by the following expression RMS Residual Error b 3.5 k (I) (1) Initial Error Ampl. The value of k ranges from approximately 0.001 for low spatial frequency initial errors up to 0.05 for higher error frequencies (e.g. 5 cycles/diameter). The studies also yielded insight to the forces required to produce typical corrections at both the center and edges of the mirror panels. Additionally, the data lends itself to rapid evaluation of the effects of trading faceplate weight for increased actuator count,

Investigating late-onset ADHD: a population cohort investigation.

PubMed

Cooper, Miriam; Hammerton, Gemma; Collishaw, Stephan; Langley, Kate; Thapar, Ajay; Dalsgaard, Søren; Stergiakouli, Evie; Tilling, Kate; Davey Smith, George; Maughan, Barbara; O'Donovan, Michael; Thapar, Anita; Riglin, Lucy

2018-04-23

Adult ADHD has been assumed to be a continuation of childhood-onset ADHD. However, recent studies have identified individuals with ADHD in adulthood who have not had ADHD in childhood. Whether or not these individuals have a 'typical' neurodevelopmental profile is not clear. We tested two explanations for the emergence of apparent late-onset ADHD symptomatology using the ALSPAC epidemiological cohort, by grouping individuals according to their scores on the Strengths and Difficulties Questionnaire (SDQ) hyperactivity subscale at ages 12 and 17 years. First, we tested whether some of those with apparent late-onset ADHD symptoms had been potentially misclassified on the basis of earlier SDQ hyperactivity scores (ages 7, 8 and 9 years) or of subthreshold symptoms at age 12 years. Second, we investigated the possibility that those with 'genuine' late-onset ADHD symptoms had a delayed manifestation of the same liability that underlies childhood-onset symptoms, by investigating whether they had a similar profile of neurodevelopmental impairments (in the domains of autistic symptomatology, language, reading, spelling, executive functioning and IQ) as those with typical childhood-onset ADHD. N = 56/75 (75%) of those with apparent late-onset ADHD had had high ADHD scores at least one point in childhood, suggesting that they may have been misclassified on the basis of their score at age 12 years. The remaining 19 individuals (25%) with genuine late-onset ADHD symptoms did not show a profile of neurodevelopmental impairment typically seen in ADHD, instead showing similar levels of autistic symptoms, language skills, executive functioning ability and IQ to those without ADHD symptoms. The only exceptions were that this group showed reading and spelling problems at age 9 years. Our work suggests that this small number of individuals with genuine late-onset symptoms may not be most appropriately considered as having a typical neurodevelopmental disorder. © 2018 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

Flood hazard assessment for french NPPs

NASA Astrophysics Data System (ADS)

Rebour, Vincent; Duluc, Claire-Marie; Guimier, Laurent

2015-04-01

This paper presents the approach for flood hazard assessment for NPP which is on-going in France in the framework of post-Fukushima activities. These activities were initially defined considering both European "stress tests" of NPPs pursuant to the request of the European Council, and the French safety audit of civilian nuclear facilities in the light of the Fukushima Daiichi accident. The main actors in that process are the utility (EDF is, up to date, the unique NPP's operator in France), the regulatory authority (ASN) and its technical support organization (IRSN). This paper was prepared by IRSN, considering official positions of the other main actors in the current review process, it was not officially endorsed by them. In France, flood hazard to be considered for design basis definition (for new NPPs and for existing NPPs in periodic safety reviews conducted every 10 years) was revised before Fukushima-Daichi accident, due to le Blayais NPP December 1999 experience (partial site flooding and loss of some safety classified systems). The paper presents in the first part an overview of the revised guidance for design basis flood. In order to address design extension conditions (conditions that could result from natural events exceeding the design basis events), a set of flooding scenarios have been defined by adding margins on the scenarios that are considered for the design. Due to the diversity of phenomena to be considered for flooding hazard, the margin assessment is specific to each flooding scenario in terms of parameter to be penalized and of degree of variation of this parameter. The general approach to address design extension conditions is presented in the second part of the paper. The next parts present the approach for five flooding scenarios including design basis scenario and additional margin to define design extension scenarios.

Assessment of CFD-based Response Surface Model for Ares I Supersonic Ascent Aerodynamics

NASA Technical Reports Server (NTRS)

Hanke, Jeremy L.

2011-01-01

The Ascent Force and Moment Aerodynamic (AFMA) Databases (DBs) for the Ares I Crew Launch Vehicle (CLV) were typically based on wind tunnel (WT) data, with increments provided by computational fluid dynamics (CFD) simulations for aspects of the vehicle that could not be tested in the WT tests. During the Design Analysis Cycle 3 analysis for the outer mold line (OML) geometry designated A106, a major tunnel mishap delayed the WT test for supersonic Mach numbers (M) greater than 1.6 in the Unitary Plan Wind Tunnel at NASA Langley Research Center, and the test delay pushed the final delivery of the A106 AFMA DB back by several months. The aero team developed an interim database based entirely on the already completed CFD simulations to mitigate the impact of the delay. This CFD-based database used a response surface methodology based on radial basis functions to predict the aerodynamic coefficients for M > 1.6 based on only the CFD data from both WT and flight Reynolds number conditions. The aero team used extensive knowledge of the previous AFMA DB for the A103 OML to guide the development of the CFD-based A106 AFMA DB. This report details the development of the CFD-based A106 Supersonic AFMA DB, constructs a prediction of the database uncertainty using data available at the time of development, and assesses the overall quality of the CFD-based DB both qualitatively and quantitatively. This assessment confirms that a reasonable aerodynamic database can be constructed for launch vehicles at supersonic conditions using only CFD data if sufficient knowledge of the physics and expected behavior is available. This report also demonstrates the applicability of non-parametric response surface modeling using radial basis functions for development of aerodynamic databases that exhibit both linear and non-linear behavior throughout a large data space.

Easy-going, rational, susceptible and struggling eaters: A segmentation study based on eating behaviour tendencies.

PubMed

Pentikäinen, Saara; Arvola, Anne; Karhunen, Leila; Pennanen, Kyösti

2018-01-01

Eating behaviour tendencies, emotional eating (EE), uncontrolled eating (UE) and cognitive restraint (CR), are associated with various indicators of physical and mental health. Therefore, it is important to understand these tendencies in order to design interventions to improve health. Previous research has mostly examined eating behaviour tendencies individually, without considering typical combinations of these tendencies or their manifestation in well-being and food choices. This study aimed to understand the interactive occurrence of EE, UE and CR in two independent populations. Finnish (n = 1060) and German (n = 1070) samples were segmented on the basis of their responses to a modified Three-Factor Eating Questionnaire (TFEQ-R15). Well-being, coping strategies and food consumption habits of the segments were studied. Segmentation revealed four segments: "Susceptible", "Easy-going", "Rational" and "Struggling". These segments were similar in both countries with regard to well-being, coping strategies and food choices. EE and UE co-occurred, and these tendencies were mainly responsible for differentiating the segments. Members of the "Rational" and "Easy-going" segments, who had low scores for EE and UE, tended to experience vitality and positive emotions in life, and contentment with their eating. By contrast, the "Susceptible" and "Struggling" segments, with more pronounced tendencies towards EE and UE, experienced lower levels of vitality and less frequently positive emotions, applied less adaptive coping strategies and experienced more discontent with eating. The results of the current study suggest that it is possible to identify segments, with differing eating habits, coping strategies and well-being on the basis of the eating behaviour tendencies EE, UE and CR. We discuss possible viewpoints for the design of interventions and food products to help people towards psychologically and physiologically healthier eating styles. Copyright © 2017 Elsevier Ltd. All rights reserved.

Universal Design in Postsecondary Education: Process, Principles, and Applications

ERIC Educational Resources Information Center

Burgstahler, Sheryl

2009-01-01

Designing any product or environment involves the consideration of many factors, including aesthetics, engineering options, environmental issues, safety concerns, industry standards, and cost. Typically, designers focus their attention on the average user. In contrast, universal design (UD), according to the Center for Universal Design, "is…

Task 4 : testing Iowa Portland cement concrete mixtures for the AASHTO mechanistic-empirical pavement design procedure.

DOT National Transportation Integrated Search

2008-05-01

The present research project was designed to identify the typical Iowa material input values that are required by the Mechanistic- : Empirical Pavement Design Guide (MEPDG) for the Level 3 concrete pavement design. It was also designed to investigate...

Authorization basis supporting documentation for plutonium finishing plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, J.P., Fluor Daniel Hanford

1997-03-05

The identification and definition of the authorization basis for the Plutonium Finishing Plant (PFP) facility and operations are essential for compliance to DOE Order 5480.21, Unreviewed Safety Questions. The authorization basis, as defined in the Order, consists of those aspects of the facility design basis, i.e., the structures, systems and components (SSCS) and the operational requirements that are considered to be important to the safety of operations and are relied upon by DOE to authorize operation of the facility. These facility design features and their function in various accident scenarios are described in WHC-SD-CP-SAR-021, Plutonium Finishing Plant Final Safety Analysismore » Report (FSAR), Chapter 9, `Accident Analysis.` Figure 1 depicts the relationship of the Authorization Basis to its components and other information contained in safety documentation supporting the Authorization Basis. The PFP SSCs that are important to safety, collectively referred to as the `Safety Envelope` are discussed in various chapters of the FSAR and in WHC-SD-CP-OSR-010, Plutonium Finishing Plant Operational Safety Requirements. Other documents such as Criticality Safety Evaluation Reports (CSERS) address and support some portions of the Authorization Basis and Safety Envelope.« less

Mathematical and numerical challenges in living biological materials

NASA Astrophysics Data System (ADS)

Forest, M. Gregory; Vasquez, Paula A.

2013-10-01

The proclaimed Century of Biology is rapidly leading to the realization of how starkly different and more complex biological materials are than the materials that underpinned the industrial and technological revolution. These differences arise, in part, because biological matter exhibits both viscous and elastic behavior. Moreover, this behavior varies across the frequency, wavelength and amplitude spectrum of forcing. This broadclass of responsesin biological matter requires multiple frequency-dependent functions to specify material behavior, instead of a discrete set of parameters that relate to either viscosity or elasticity. This complexity prevails even if the biological matter is assumed to be spatially homogeneous, which is rarely true. However, very little progress has been made on the characterization of heterogeneity and how to build that information into constitutive laws and predictive models. In addition, most biological matter is non-stationary, which motivates the term "living". Biomaterials typically are in an active state in order to perform certain functions, and they often are modified or replenished on the basis of external stimuli. It has become popular in materials engineering to try to duplicate some of the functionality of biomaterials, e.g., a lot of effort has gone into the design of self-assembling, self-healing and shape shifting materials. These distinguishing features of biomaterials require significantly more degrees of freedom than traditional composites and many of the molecular species and their roles in functionality have yet to be determined. A typical biological material includes small molecule biochemical species that react and diffuse within larger species. These large molecular weightspecies provide the primary structural and biophysical properties of the material. The small molecule binding and unbinding kinetics serves to modulate material properties, and typical small molecule production and release are governed by external stimuli (e.g., stress). The bottom line is that the mathematical and numerical tools of 20th Century materials science are often insufficient for describing biological materials and for predicting their behavior both in vitro and in vivo.

Reviewed approach to defining the Active Interlock Envelope for Front End ray tracing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seletskiy, S.; Shaftan, T.

To protect the NSLS-II Storage Ring (SR) components from damage from synchrotron radiation produced by insertion devices (IDs) the Active Interlock (AI) keeps electron beam within some safe envelope (a.k.a Active Interlock Envelope or AIE) in the transverse phase space. The beamline Front Ends (FEs) are designed under assumption that above certain beam current (typically 2 mA) the ID synchrotron radiation (IDSR) fan is produced by the interlocked e-beam. These assumptions also define how the ray tracing for FE is done. To simplify the FE ray tracing for typical uncanted ID it was decided to provide the Mechanical Engineering groupmore » with a single set of numbers (x,x’,y,y’) for the AIE at the center of the long (or short) ID straight section. Such unified approach to the design of the beamline Front Ends will accelerate the design process and save valuable human resources. In this paper we describe our new approach to defining the AI envelope and provide the resulting numbers required for design of the typical Front End.« less

Surrogate models for sheet metal stamping problem based on the combination of proper orthogonal decomposition and radial basis function

NASA Astrophysics Data System (ADS)

Dang, Van Tuan; Lafon, Pascal; Labergere, Carl

2017-10-01

In this work, a combination of Proper Orthogonal Decomposition (POD) and Radial Basis Function (RBF) is proposed to build a surrogate model based on the Benchmark Springback 3D bending from the Numisheet2011 congress. The influence of the two design parameters, the geometrical parameter of the die radius and the process parameter of the blank holder force, on the springback of the sheet after a stamping operation is analyzed. The classical Design of Experience (DoE) uses Full Factorial to design the parameter space with sample points as input data for finite element method (FEM) numerical simulation of the sheet metal stamping process. The basic idea is to consider the design parameters as additional dimensions for the solution of the displacement fields. The order of the resultant high-fidelity model is reduced through the use of POD method which performs model space reduction and results in the basis functions of the low order model. Specifically, the snapshot method is used in our work, in which the basis functions is derived from snapshot deviation of the matrix of the final displacements fields of the FEM numerical simulation. The obtained basis functions are then used to determine the POD coefficients and RBF is used for the interpolation of these POD coefficients over the parameter space. Finally, the presented POD-RBF approach which is used for shape optimization can be performed with high accuracy.

Correlation consistent basis sets for the atoms In–Xe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahler, Andrew; Wilson, Angela K., E-mail: akwilson@unt.edu

In this work, the correlation consistent family of Gaussian basis sets has been expanded to include all-electron basis sets for In–Xe. The methodology for developing these basis sets is described, and several examples of the performance and utility of the new sets have been provided. Dissociation energies and bond lengths for both homonuclear and heteronuclear diatomics demonstrate the systematic convergence behavior with respect to increasing basis set quality expected by the family of correlation consistent basis sets in describing molecular properties. Comparison with recently developed correlation consistent sets designed for use with the Douglas-Kroll Hamiltonian is provided.

Towards a building typology and terminology for Irish hospitals.

PubMed

Grey, T; Kennelly, S; de Freine, P; Mahon, S; Mannion, V; O'Neill, D

2017-02-01

The physical form of the hospital environment shapes the care setting and influences the relationship of the hospital to the community. Due to ongoing demographic change, evolving public health needs, and advancing medical practice, typical hospitals are frequently redeveloped, retrofitted, or expanded. It is argued that multi-disciplinary and multi-stakeholder approaches are required to ensure that hospital design matches these increasingly complex needs. To facilitate such a conversation across different disciplines, experts, and community stakeholders, it is helpful to establish a hospital typology and associated terminology as part of any collaborative process. Examine the literature around hospital design, and review the layout and overall form of a range of typical Irish acute public hospitals, to outline an associated building typology, and to establish the terminology associated with the planning and design of these hospitals in Ireland. Searches in 'Academic Search Complete', 'Compendex', 'Google', 'Google Scholar', 'JSTOR', 'PADDI', 'Science Direct', 'Scopus', 'Web of Science', and Trinity College Dublin Library. The search terms included: 'hospital design history'; 'hospital typology'; 'hospital design terminology'; and 'hospital design Ireland'. Typical hospitals are composed of different layouts due to development over time; however, various discrete building typologies can still be determined within many hospitals. This paper presents a typology illustrating distinct layout, circulation, and physical form characteristics, along with a hospital planning and design terminology of key terms and definitions. This typology and terminology define the main components of Irish hospital building design to create a shared understanding around design, and support stakeholder engagement, as part of any collaborative design process.

INVESTIGATION OF SEISMIC PERFORMANCE AND DESIGN OF TYPICAL CURVED AND SKEWED BRIDGES IN COLORADO

DOT National Transportation Integrated Search

2018-01-15

This report summarizes the analytical studies on the seismic performance of typical Colorado concrete bridges, particularly those with curved and skewed configurations. A set of bridge models with different geometric configurations derived from a pro...

It Takes a Village to Design a Course: Embedding a Librarian in Course Design

ERIC Educational Resources Information Center

Mudd, Alex; Summey, Terri; Upson, Matt

2015-01-01

Often associated with online learning, instructional design is a process utilized in efficiently designing training and instruction to help ensure effectiveness. Typically, the instructional systems design (ISD) process uses a team-based approach, consisting of an instructor, a facilitator, a designer and a subject matter expert. Although library…

Research Needs for Human Factors

DTIC Science & Technology

1983-01-01

their relative merits. Until such comparisons are made, practitioners will continue to advocate their own products without a basis for choice among ...judgments among a group of experts; (2) formulating questions for "experts in a way that is compatible with their mental structures or "cognitive...system* Typically the operators work in teams and control compute3, which in turn mediate information flow among various automatic components. Other

27. Photocopy of scale drawing (from Station 'L' office files, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. Photocopy of scale drawing (from Station 'L' office files, Portland, Oregon) Portland General Electric proposal to city/state, 10/15/1929 FOUNDATION AND LOCATION OF THE STATION SCREEN HOUSE AND A LOOK AT THE TYPICAL DREDGING OF THE RIVER BED WHICH TOOK PLACE ON A PERIODIC BASIS AT STATION 'L' - Portland General Electric Company, Station "L", 1841 Southeast Water Street, Portland, Multnomah County, OR

[Genetic basis for skeletal disease. Dental management of patients with bone diseases].

PubMed

Shintani, Seikou; Ooshima, Takashi

2010-08-01

Malformation of teeth can be found in patients with bone diseases, which was induced when the disease occurred during the tooth formation. The tooth malformation shows typical manifestations of the disease, which may demonstrate the occurrence of the bone disease. In this article, dental management of the patients with bone diseases such as X-linked hypophosphatemic rickets, osteogenesis imperfecta, and hypophosphatasia was presented.

Physiography, geology, and land cover of four watersheds in Eastern Puerto Rico

Treesearch

S.F. Murphy; R.F. Stallard; M.C. Larsen; W.A. Gould

2012-01-01

Four watersheds with differing geology and land cover in eastern Puerto Rico have been studied on a long-term basis by the U.S. Geological Survey to evaluate water, energy, and biogeochemical budgets. These watersheds are typical of tropical, island-arc settings found in many parts of the world. Two watersheds are located on coarse-grained granitic rocks that weather...

Labor Market Earnings of American Artists in 1980. A Report to the National Endowment for the Arts.

ERIC Educational Resources Information Center

Filer, Randall K.

While some studies of the earnings of artists have typically claimed that artists earn significantly less than other workers, others suggest that there is no basis for concluding that artists earn any less on average than they would in other jobs. This study presents information regarding the earning and labor market success of artists in the…

How rolling forecasting facilitates dynamic, agile planning.

PubMed

Miller, Debra; Allen, Michael; Schnittger, Stephanie; Hackman, Theresa

2013-11-01

Rolling forecasting may be used to replace or supplement the annual budget process. The rolling forecast typically builds on the organization's strategic financial plan, focusing on the first three years of plan projections and comparing the strategic financial plan assumptions with the organization's expected trajectory. Leaders can then identify and respond to gaps between the rolling forecast and the strategic financial plan on an ongoing basis.

Continuous prestressed concrete girder bridges volume 1 : literature review and preliminary designs.

DOT National Transportation Integrated Search

2012-06-01

The Texas Department of Transportation (TxDOT) is currently designing typical highway bridge structures as simply supported using standard precast, pretensioned girders. TxDOT is interested in developing additional economical design alternatives for ...

Intelligence, personality, and interests: evidence for overlapping traits.

PubMed

Ackerman, P L; Heggestad, E D

1997-03-01

The authors review the development of the modern paradigm for intelligence assessment and application and consider the differentiation between intelligence-as-maximal performance and intelligence-as-typical performance. They review theories of intelligence, personality, and interest as a means to establish potential overlap. Consideration of intelligence-as-typical performance provides a basis for evaluation of intelligence-personality and intelligence-interest relations. Evaluation of relations among personality constructs, vocational interests, and intellectual abilities provides evidence for communality across the domains of personality of J. L. Holland's (1959) model of vocational interests. The authors provide an extensive meta-analysis of personality-intellectual ability correlations, and a review of interest-intellectual ability associations. They identify 4 trait complexes: social, clerical/conventional, science/math, and intellectual/cultural.

Multimodal interactions in typically and atypically developing children: natural versus artificial environments.

PubMed

Giannopulu, Irini

2013-11-01

This review addresses the central role played by multimodal interactions in neurocognitive development. We first analyzed our studies of multimodal verbal and nonverbal cognition and emotional interactions within neuronal, that is, natural environments in typically developing children. We then tried to relate them to the topic of creating artificial environments using mobile toy robots to neurorehabilitate severely autistic children. By doing so, both neural/natural and artificial environments are considered as the basis of neuronal organization and reorganization. The common thread underlying the thinking behind this approach revolves around the brain's intrinsic properties: neuroplasticity and the fact that the brain is neurodynamic. In our approach, neural organization and reorganization using natural or artificial environments aspires to bring computational perspectives into cognitive developmental neuroscience.

Global Water Cycle Agreement in the Climate Models Assessed in the IPCC AR4

NASA Technical Reports Server (NTRS)

Waliser, D.; Seo, K. -W.; Schubert, S.; Njoku, E.

2007-01-01

This study examines the fidelity of the global water cycle in the climate model simulations assessed in the IPCC Fourth Assessment Report. The results demonstrate good model agreement in quantities that have had a robust global observational basis and that are physically unambiguous. The worst agreement occurs for quantities that have both poor observational constraints and whose model representations can be physically ambiguous. In addition, components involving water vapor (frozen water) typically exhibit the best (worst) agreement, and fluxes typically exhibit better agreement than reservoirs. These results are discussed in relation to the importance of obtaining accurate model representation of the water cycle and its role in climate change. Recommendations are also given for facilitating the needed model improvements.

Lyme disease: review

PubMed Central

Czepiel, Jacek; Leśniak, Maciej R.; Garlicki, Aleksander; Mach, Tomasz

2012-01-01

Lyme disease is a multi-organ animal-borne disease, caused by spirochetes of Borrelia burgdorferi (Bb), which typically affect the skin, nervous system, musculoskeletal system and heart. A history of confirmed exposure to tick bites, typical signs and symptoms of Lyme borreliosis and positive tests for anti-Bb antibodies, are the basis of a diagnosis. A two-step diagnosis is necessary: the first step is based on a high sensitivity ELISA test with positive results confirmed by a more specific Western blot assay. Antibiotic therapy is curative in most cases, but some patients develop chronic symptoms, which do not respond to antibiotics. The aim of this review is to summarize our current knowledge of the symptoms, clinical diagnosis and treatment of Lyme borreliosis. PMID:23319969

Options for rural electrification in Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vera, J.G.

1992-09-01

This paper summarizes a study which examined 19 commercially available options for electrifying remote communities in Mexico. Characteristics of a typical community are defined and, using 7 of the technologies, power systems are designed capable of supporting this community. The performance of these systems is evaluated with respect to their ability to satisfy 11 technical design objectives, 5 socioeconomic objectives, and their impact on the environment. A photovoltaic- diesel generator hybrid system with wind generator option is recommended for the typical community.

A Method for Generating Reduced Order Linear Models of Supersonic Inlets

NASA Technical Reports Server (NTRS)

Chicatelli, Amy; Hartley, Tom T.

1997-01-01

For the modeling of high speed propulsion systems, there are at least two major categories of models. One is based on computational fluid dynamics (CFD), and the other is based on design and analysis of control systems. CFD is accurate and gives a complete view of the internal flow field, but it typically has many states and runs much slower dm real-time. Models based on control design typically run near real-time but do not always capture the fundamental dynamics. To provide improved control models, methods are needed that are based on CFD techniques but yield models that are small enough for control analysis and design.

Design of a digital ride quality augmentation system for commuter aircraft

NASA Technical Reports Server (NTRS)

Hammond, T. A.; Amin, S. P.; Paduano, J. D.; Downing, D. R.

1984-01-01

Commuter aircraft typically have low wing loadings, and fly at low altitudes, and so they are susceptible to undesirable accelerations caused by random atmospheric turbulence. Larger commercial aircraft typically have higher wing loadings and fly at altitudes where the turbulence level is lower, and so they provide smoother rides. This project was initiated based on the goal of making the ride of the commuter aircraft as smooth as the ride experienced on the major commercial airliners. The objectives of this project were to design a digital, longitudinal mode ride quality augmentation system (RQAS) for a commuter aircraft, and to investigate the effect of selected parameters on those designs.

Investigating Instructional Design Management and Leadership Competencies--A Delphi Study

ERIC Educational Resources Information Center

Gardner, Joel; Chongwony, Lewis; Washington, Tawana

2018-01-01

Research in instructional design and educational technology journals typically focuses on the theories, technologies, and processes related to practice of instructional design. There is little research emphasis, however, on leadership and management of instructional design in higher education. Investigating the competencies associated with…

Application of the dual-kinetic-balance sets in the relativistic many-body problem of atomic structure

NASA Astrophysics Data System (ADS)

Beloy, Kyle; Derevianko, Andrei

2008-09-01

The dual-kinetic-balance (DKB) finite basis set method for solving the Dirac equation for hydrogen-like ions [V.M. Shabaev et al., Phys. Rev. Lett. 93 (2004) 130405] is extended to problems with a non-local spherically-symmetric Dirac-Hartree-Fock potential. We implement the DKB method using B-spline basis sets and compare its performance with the widely-employed approach of Notre Dame (ND) group [W.R. Johnson, S.A. Blundell, J. Sapirstein, Phys. Rev. A 37 (1988) 307-315]. We compare the performance of the ND and DKB methods by computing various properties of Cs atom: energies, hyperfine integrals, the parity-non-conserving amplitude of the 6s-7s transition, and the second-order many-body correction to the removal energy of the valence electrons. We find that for a comparable size of the basis set the accuracy of both methods is similar for matrix elements accumulated far from the nuclear region. However, for atomic properties determined by small distances, the DKB method outperforms the ND approach. In addition, we present a strategy for optimizing the size of the basis sets by choosing progressively smaller number of basis functions for increasingly higher partial waves. This strategy exploits suppression of contributions of high partial waves to typical many-body correlation corrections.

Efficient Computation of Sparse Matrix Functions for Large-Scale Electronic Structure Calculations: The CheSS Library.

PubMed

Mohr, Stephan; Dawson, William; Wagner, Michael; Caliste, Damien; Nakajima, Takahito; Genovese, Luigi

2017-10-10

We present CheSS, the "Chebyshev Sparse Solvers" library, which has been designed to solve typical problems arising in large-scale electronic structure calculations using localized basis sets. The library is based on a flexible and efficient expansion in terms of Chebyshev polynomials and presently features the calculation of the density matrix, the calculation of matrix powers for arbitrary powers, and the extraction of eigenvalues in a selected interval. CheSS is able to exploit the sparsity of the matrices and scales linearly with respect to the number of nonzero entries, making it well-suited for large-scale calculations. The approach is particularly adapted for setups leading to small spectral widths of the involved matrices and outperforms alternative methods in this regime. By coupling CheSS to the DFT code BigDFT, we show that such a favorable setup is indeed possible in practice. In addition, the approach based on Chebyshev polynomials can be massively parallelized, and CheSS exhibits excellent scaling up to thousands of cores even for relatively small matrix sizes.

Study on real-time force feedback for a master-slave interventional surgical robotic system.

PubMed

Guo, Shuxiang; Wang, Yuan; Xiao, Nan; Li, Youxiang; Jiang, Yuhua

2018-04-13

In robot-assisted catheterization, haptic feedback is important, but is currently lacking. In addition, conventional interventional surgical robotic systems typically employ a master-slave architecture with an open-loop force feedback, which results in inaccurate control. We develop herein a novel real-time master-slave (RTMS) interventional surgical robotic system with a closed-loop force feedback that allows a surgeon to sense the true force during remote operation, provide adequate haptic feedback, and improve control accuracy in robot-assisted catheterization. As part of this system, we also design a unique master control handle that measures the true force felt by a surgeon, providing the basis for the closed-loop control of the entire system. We use theoretical and empirical methods to demonstrate that the proposed RTMS system provides a surgeon (using the master control handle) with a more accurate and realistic force sensation, which subsequently improves the precision of the master-slave manipulation. The experimental results show a substantial increase in the control accuracy of the force feedback and an increase in operational efficiency during surgery.

Glycomyces scopariae sp. nov. and Glycomyces mayteni sp. nov., isolated from medicinal plants in China.

PubMed

Qin, Sheng; Chen, Hua-Hong; Klenk, Hans-Peter; Zhao, Guo-Zhen; Li, Jie; Xu, Li-Hua; Li, Wen-Jun

2009-05-01

Two actinomycete strains, designated YIM 56256(T) and YIM 61331(T), were isolated from the roots of Scoparia dulcis and Maytenus austroyunnanensis, two Chinese medicinal plants, and their taxonomic status was established based on a polyphasic investigation. The organisms were found to have chemical and morphological markers typical of members of the genus Glycomyces. 16S rRNA gene sequence analysis showed that they were closely related to each other and to Glycomyces sambucus E71(T). A battery of physiological characteristics and levels of DNA-DNA relatedness indicated that strains YIM 56256(T) and YIM 61331(T) represent two novel species, clearly different from the related known Glycomyces species. On the basis of the data presented, it is evident that each of these strains represents a novel species of the genus Glycomyces, for which the names Glycomyces scopariae sp. nov. (type strain YIM 56256(T) =KCTC 19158(T) =DSM 44968(T)) and Glycomyces mayteni sp. nov. (type strain YIM 61331(T) =KCTC 19527(T) =CCTCC AA 208004(T)) are proposed.

A new temperature threshold detector - Application to missile monitoring

NASA Astrophysics Data System (ADS)

Coston, C. J.; Higgins, E. V.

Comprehensive thermal surveys within the case of solid propellant ballistic missile flight motors are highly desirable. For example, a problem involving motor failures due to insulator cracking at motor ignition, which took several years to solve, could have been identified immediately on the basis of a suitable thermal survey. Using conventional point measurements, such as those utilizing typical thermocouples, for such a survey on a full scale motor is not feasible because of the great number of sensors and measurements required. An alternate approach recognizes that temperatures below a threshold (which depends on the material being monitored) are acceptable, but higher temperatures exceed design margins. In this case hot spots can be located by a grid of wire-like sensors which are sensitive to temperature above the threshold anywhere along the sensor. A new type of temperature threshold detector is being developed for flight missile use. The considered device consists of KNO3 separating copper and Constantan metals. Above the KNO3 MP, galvanic action provides a voltage output of a few tenths of a volt.

Cost Efficiency of Sea Freight and Lowering Cost of Consumption Goods

NASA Astrophysics Data System (ADS)

Rum, Muh

2018-05-01

The subject of this research are administrative processes related to loading and unloading costin term of a ship’s arrival and departure to seaports,typically attributed to elevated levels of cost of labor, handling cost, dwelling time, and port fee which required to complete the related administrative tasks. Research design by comparative method in administrative way, which compare with many way implemented of previous practitioner export and import. In the previous phases of the research, an average expected cost of the administrative labor cost in traditional seaport clusters in eastern Indonesia was identified and quantified on an hourly basis. This research continues in its aim by using the results of the previous research as a starting point, and Find that enterprise resource planning and improvement, transactional due diligence and merger integration, positively affect and not associated with cost reduction. Moreover variable of reducing inventory cost affect and associated with reducing cost. The main hypothesis is that the usage of such a new model will result in a measurable decrease of the required freight cost in sea port, which indirectly reduce the consumption goods.

Screening technologies for detection of swallowed packages of narcotics

NASA Astrophysics Data System (ADS)

Burnett, Lowell J.; Magnuson, Erik E.; Sheldon, Alan G.; Kumar, Sankaran

1997-01-01

An increasingly popular method of transporting modest quantities of narcotics across international borders is to employ 'swallowers'. These are people who typically enter the country as international airline passengers after swallowing small, water-tight packages of heroin and/or cocaine. Rapid and accurate identification of swallowers in the airport environment poses difficult technical changes. Commonly used medical inspection technologies fall into one of two categories. Either they are unsuitable for widespread use, or they do not provide adequate information. An example of the former is x-ray scanning, while an example of the latter is ultrasonic imaging. Quantum Magnetics has developed a system to screen selected airline passengers for the presence of swallowed narcotics. The system utilizes magnetic resonance, which provides the physical basis for the magnetic resonance imaging systems widely used in the medical community as an alternative to x-rays. The system is currently operational, and laboratory performance testing is complete. Both the design of the system and its performance will be discussed. This work was sponsored in part by the Office of National Drug Control Policy and the US Customs Service.

How Pleasant Sounds Promote and Annoying Sounds Impede Health: A Cognitive Approach

PubMed Central

Andringa, Tjeerd C.; Lanser, J. Jolie L.

2013-01-01

This theoretical paper addresses the cognitive functions via which quiet and in general pleasurable sounds promote and annoying sounds impede health. The article comprises a literature analysis and an interpretation of how the bidirectional influence of appraising the environment and the feelings of the perceiver can be understood in terms of core affect and motivation. This conceptual basis allows the formulation of a detailed cognitive model describing how sonic content, related to indicators of safety and danger, either allows full freedom over mind-states or forces the activation of a vigilance function with associated arousal. The model leads to a number of detailed predictions that can be used to provide existing soundscape approaches with a solid cognitive science foundation that may lead to novel approaches to soundscape design. These will take into account that louder sounds typically contribute to distal situational awareness while subtle environmental sounds provide proximal situational awareness. The role of safety indicators, mediated by proximal situational awareness and subtle sounds, should become more important in future soundscape research. PMID:23567255

Spontaneous giving and calculated greed.

PubMed

Rand, David G; Greene, Joshua D; Nowak, Martin A

2012-09-20

Cooperation is central to human social behaviour. However, choosing to cooperate requires individuals to incur a personal cost to benefit others. Here we explore the cognitive basis of cooperative decision-making in humans using a dual-process framework. We ask whether people are predisposed towards selfishness, behaving cooperatively only through active self-control; or whether they are intuitively cooperative, with reflection and prospective reasoning favouring 'rational' self-interest. To investigate this issue, we perform ten studies using economic games. We find that across a range of experimental designs, subjects who reach their decisions more quickly are more cooperative. Furthermore, forcing subjects to decide quickly increases contributions, whereas instructing them to reflect and forcing them to decide slowly decreases contributions. Finally, an induction that primes subjects to trust their intuitions increases contributions compared with an induction that promotes greater reflection. To explain these results, we propose that cooperation is intuitive because cooperative heuristics are developed in daily life where cooperation is typically advantageous. We then validate predictions generated by this proposed mechanism. Our results provide convergent evidence that intuition supports cooperation in social dilemmas, and that reflection can undermine these cooperative impulses.

A comparison of naïve and sophisticated subject behavior with game theoretic predictions

PubMed Central

McCabe, Kevin A.; Smith, Vernon L.

2000-01-01

We use an extensive form two-person game as the basis for two experiments designed to compare the behavior of two groups of subjects with each other and with the subgame perfect theoretical prediction in an anonymous interaction protocol. The two subject groups are undergraduates and advanced graduate students, the latter having studied economics and game theory. There is no difference in their choice behavior, and both groups depart substantially from game theoretic predictions. We also compare a subsample of the same graduate students with a typical undergraduate sample in an asset trading environment in which inexperienced undergraduates invariably produce substantial departures from the rational expectations prediction. In this way, we examine how robust are the results across two distinct anonymous interactive environments. In the constant sum trading game, the graduate students closely track the predictions of rational theory. Our interpretation is that the graduate student subjects' departure from subgame perfection to achieve cooperative outcomes in the two-person bargaining game is a consequence of a deliberate strategy and is not the result of error or inadequate learning. PMID:10725349

Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity

PubMed Central

Sakamoto, Yasumitsu; Suzuki, Yoshiyuki; Iizuka, Ippei; Tateoka, Chika; Roppongi, Saori; Fujimoto, Mayu; Inaka, Koji; Tanaka, Hiroaki; Yamada, Mitsugu; Ohta, Kazunori; Gouda, Hiroaki; Nonaka, Takamasa; Ogasawara, Wataru; Tanaka, Nobutada

2015-01-01

The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to the S46 family of serine peptidases and preferentially cleaves substrates with Asp/Glu at the P1 position. The molecular mechanism underlying the substrate specificity of PgDPP11, however, is unknown. Here, we report the crystal structure of PgDPP11. The enzyme contains a catalytic domain with a typical double β-barrel fold and a recently identified regulatory α-helical domain. Crystal structure analyses, docking studies, and biochemical studies revealed that the side chain of Arg673 in the S1 subsite is essential for recognition of the Asp/Glu side chain at the P1 position of the bound substrate. Because S46 peptidases are not found in mammals and the Arg673 is conserved among DPP11s, we anticipate that DPP11s could be utilised as targets for antibiotics. In addition, the present structure analyses could be useful templates for the design of specific inhibitors of DPP11s from pathogenic organisms. PMID:26057589

Contextual Factors Explain Risk-Seeking Preferences in Rhesus Monkeys

PubMed Central

Heilbronner, Sarah R.; Hayden, Benjamin Y.

2012-01-01

In contrast to humans and most other animals, rhesus macaques strongly prefer risky rewards to safe ones with similar expected value. Why macaques prefer risk while other animals typically avoid it remains puzzling and challenges the idea that monkeys provide a model for human economic behavior. Here we argue that monkeys’ risk-seeking preferences are neither mysterious nor unique. Risk-seeking in macaques is possibly induced by specific elements of the tasks that have been used to measure their risk preferences. The most important of these elements are (1) very small stakes, (2) serially repeated gambles with short delays between trials, and (3) task parameters that are learned through experience, not described verbally. Together, we hypothesize that these features will readily induce risk-seeking in monkeys, humans, and rats. Thus, elements of task design that are often ignored when comparing studies of risk attitudes can easily overwhelm basal risk preferences. More broadly, these results highlight the fundamental importance of understanding the psychological basis of economic decisions in interpreting preference data and corresponding neural measures. PMID:23378827

Development of noSQL data storage for the ATLAS PanDA Monitoring System

NASA Astrophysics Data System (ADS)

Ito, H.; Potekhin, M.; Wenaus, T.

2012-12-01

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with an R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic rate of queries. In conclusion, we present our experience with operating a Cassandra cluster over an extended period of time and with data load adequate for planned application.

A Discussion of Issues in Integrity Constraint Monitoring

NASA Technical Reports Server (NTRS)

Fernandez, Francisco G.; Gates, Ann Q.; Cooke, Daniel E.

1998-01-01

In the development of large-scale software systems, analysts, designers, and programmers identify properties of data objects in the system. The ability to check those assertions during runtime is desirable as a means of verifying the integrity of the program. Typically, programmers ensure the satisfaction of such properties through the use of some form of manually embedded assertion check. The disadvantage to this approach is that these assertions become entangled within the program code. The goal of the research is to develop an integrity constraint monitoring mechanism whereby a repository of software system properties (called integrity constraints) are automatically inserted into the program by the mechanism to check for incorrect program behaviors. Such a mechanism would overcome many of the deficiencies of manually embedded assertion checks. This paper gives an overview of the preliminary work performed toward this goal. The manual instrumentation of constraint checking on a series of test programs is discussed, This review then is used as the basis for a discussion of issues to be considered in developing an automated integrity constraint monitor.

Is running away right? The behavioral activation-behavioral inhibition model of anterior asymmetry.

PubMed

Wacker, Jan; Chavanon, Mira-Lynn; Leue, Anja; Stemmler, Gerhard

2008-04-01

The measurement of anterior electroencephalograph (EEG) asymmetries has become an important standard paradigm for the investigation of affective states and traits. Findings in this area are typically interpreted within the motivational direction model, which suggests a lateralization of approach and withdrawal motivational systems to the left and right anterior region, respectively. However, efforts to compare this widely adopted model with an alternative account-which relates the left anterior region to behavioral activation independent of the direction of behavior (approach or withdrawal) and the right anterior region to goal conflict-induced behavioral inhibition-are rare and inconclusive. Therefore, the authors measured the EEG in a sample of 93 young men during emotional imagery designed to provide a critical test between the 2 models. The results (e.g., a correlation between left anterior activation and withdrawal motivation) favor the alternative model on the basis of the concepts of behavioral activation and behavioral inhibition. In addition, the present study also supports an association of right parietal activation with physiological arousal and the conceptualization of parietal EEG asymmetry as a mediator of emotion-related physiological arousal. (Copyright) 2008 APA.

NASA's Zero-g aircraft operations

NASA Technical Reports Server (NTRS)

Williams, R. K.

1988-01-01

NASA's Zero-g aircraft, operated by the Johnson Space Center, provides the unique weightless or zero-g environment of space flight for hardware development and test and astronaut training purposes. The program, which began in 1959, uses a slightly modified Boeing KC-135A aircraft, flying a parabolic trajectory, to produce weightless periods of 20 to 25 seconds. The program has supported the Mercury, Gemini, Apollo, Skylab, Apollo-Soyuz and Shuttle programs as well as a number of unmanned space operations. Typical experiments for flight in the aircraft have included materials processing experiments, welding, fluid manipulation, cryogenics, propellant tankage, satellite deployment dynamics, planetary sciences research, crew training with weightless indoctrination, space suits, tethers, etc., and medical studies including vestibular research. The facility is available to microgravity research organizations on a cost-reimbursable basis, providing a large, hands-on test area for diagnostic and support equipment for the Principal Investigators and providing an iterative-type design approach to microgravity experiment development. The facility allows concepts to be proven and baseline experimentation to be accomplished relatively inexpensively prior to committing to the large expense of a space flight.

Monitoring for the management of disease risk in animal translocation programmes

USGS Publications Warehouse

Nichols, James D.; Hollmen, Tuula E.; Grand, James B.

2017-01-01

Monitoring is best viewed as a component of some larger programme focused on science or conservation. The value of monitoring is determined by the extent to which it informs the parent process. Animal translocation programmes are typically designed to augment or establish viable animal populations without changing the local community in any detrimental way. Such programmes seek to minimize disease risk to local wild animals, to translocated animals, and in some cases to humans. Disease monitoring can inform translocation decisions by (1) providing information for state-dependent decisions, (2) assessing progress towards programme objectives, and (3) permitting learning in order to make better decisions in the future. Here we discuss specific decisions that can be informed by both pre-release and post-release disease monitoring programmes. We specify state variables and vital rates needed to inform these decisions. We then discuss monitoring data and analytic methods that can be used to estimate these state variables and vital rates. Our discussion is necessarily general, but hopefully provides a basis for tailoring disease monitoring approaches to specific translocation programmes.

Design of Refractory Metal Life Test Heat Pipe and Calorimeter

NASA Technical Reports Server (NTRS)

Martin, J. J.; Reid, R. S.; Bragg-Sitton, S. M.

2010-01-01

Heat pipe life tests have seldom been conducted on a systematic basis. Typically, one or more heat pipes are built and tested for an extended period at a single temperature with simple condenser loading. Results are often reported describing the wall material, working fluid, test temperature, test duration, and occasionally the nature of any failure. Important information such as design details, processing procedures, material assay, power throughput, and radial power density are usually not mentioned. We propose to develop methods to generate carefully controlled data that conclusively establish heat pipe operating life with material-fluid combinations capable of extended operation. The test approach detailed in this Technical Publication will use 16 Mo-44.5%Re alloy/sodium heat pipe units that have an approximate12-in length and 5/8-in diameter. Two specific test series have been identified: (1) Long-term corrosion rates based on ASTM-G-68-80 (G-series) and (2) corrosion trends in a cross-correlation sequence at various temperatures and mass fluences based on a Fisher multifactor design (F-series). Evaluation of the heat pipe hardware will be performed in test chambers purged with an inert purified gas (helium or helium/argon mixture) at low pressure (10-100 torr) to provide thermal coupling between the heat pipe condenser and calorimeter. The final pressure will be selected to minimize the potential for voltage breakdown between the heat pipe and radio frequency (RF) induction coil (RF heating is currently the planned method of powering the heat pipes). The proposed calorimeter is constructed from a copper alloy and relies on a laminar flow water-coolant channel design to absorb and transport energy

Numerical assessment of fore-and-aft suspension performance to reduce whole-body vibration of wheel loader drivers

NASA Astrophysics Data System (ADS)

Fleury, Gérard; Mistrot, Pierre

2006-12-01

While driving off-road vehicles, operators are exposed to whole-body vibration acting in the fore-and-aft direction. Seat manufacturers supply products equipped with fore-and-aft suspension but only a few studies report on their performance. This work proposes a computational approach to design fore-and-aft suspensions for wheel loader seats. Field tests were conducted in a quarry to analyse the nature of vibration to which the driver was exposed. Typical input signals were recorded to be reproduced in the laboratory. Technical specifications are defined for the suspension. In order to evaluate the suspension vibration attenuation performance, a model of a sitting human body was developed and coupled to a seat model. The seat model combines the models of each suspension component. A linear two-degree-of-freedom model is used to describe the dynamic behaviour of the sitting driver. Model parameters are identified by fitting the computed apparent mass frequency response functions to the measured values. Model extensions are proposed to investigate postural effects involving variations in hands and feet positions and interaction of the driver's back with the backrest. Suspension design parameters are firstly optimized by computing the seat/man model response to sinusoidal acceleration. Four criteria including transmissibility, interaction force between the driver's back and the backrest and relative maximal displacement of the suspension are computed. A new suspension design with optimized features is proposed. Its performance is checked from calculations of the response of the seat/man model subjected to acceleration measured on the wheel loader during real work conditions. On the basis of the computed values of the SEAT factors, it is found possible to design a suspension that would increase the attenuation provided by the seat by a factor of two.

Using the living laboratory framework as a basis for understanding next-generation analyst work

NASA Astrophysics Data System (ADS)

McNeese, Michael D.; Mancuso, Vincent; McNeese, Nathan; Endsley, Tristan; Forster, Pete

2013-05-01

The preparation of next generation analyst work requires alternative levels of understanding and new methodological departures from the way current work transpires. Current work practices typically do not provide a comprehensive approach that emphasizes the role of and interplay between (a) cognition, (b) emergent activities in a shared situated context, and (c) collaborative teamwork. In turn, effective and efficient problem solving fails to take place, and practice is often composed of piecemeal, techno-centric tools that isolate analysts by providing rigid, limited levels of understanding of situation awareness. This coupled with the fact that many analyst activities are classified produces a challenging situation for researching such phenomena and designing and evaluating systems to support analyst cognition and teamwork. Through our work with cyber, image, and intelligence analysts we have realized that there is more required of researchers to study human-centered designs to provide for analyst's needs in a timely fashion. This paper identifies and describes how The Living Laboratory Framework can be utilized as a means to develop a comprehensive, human-centric, and problem-focused approach to next generation analyst work, design, and training. We explain how the framework is utilized for specific cases in various applied settings (e.g., crisis management analysis, image analysis, and cyber analysis) to demonstrate its value and power in addressing an area of utmost importance to our national security. Attributes of analyst work settings are delineated to suggest potential design affordances that could help improve cognitive activities and awareness. Finally, the paper puts forth a research agenda for the use of the framework for future work that will move the analyst profession in a viable manner to address the concerns identified.

Accounting for Uncertainties in Strengths of SiC MEMS Parts

NASA Technical Reports Server (NTRS)

Nemeth, Noel; Evans, Laura; Beheim, Glen; Trapp, Mark; Jadaan, Osama; Sharpe, William N., Jr.

2007-01-01

A methodology has been devised for accounting for uncertainties in the strengths of silicon carbide structural components of microelectromechanical systems (MEMS). The methodology enables prediction of the probabilistic strengths of complexly shaped MEMS parts using data from tests of simple specimens. This methodology is intended to serve as a part of a rational basis for designing SiC MEMS, supplementing methodologies that have been borrowed from the art of designing macroscopic brittle material structures. The need for this or a similar methodology arises as a consequence of the fundamental nature of MEMS and the brittle silicon-based materials of which they are typically fabricated. When tested to fracture, MEMS and structural components thereof show wide part-to-part scatter in strength. The methodology involves the use of the Ceramics Analysis and Reliability Evaluation of Structures Life (CARES/Life) software in conjunction with the ANSYS Probabilistic Design System (PDS) software to simulate or predict the strength responses of brittle material components while simultaneously accounting for the effects of variability of geometrical features on the strength responses. As such, the methodology involves the use of an extended version of the ANSYS/CARES/PDS software system described in Probabilistic Prediction of Lifetimes of Ceramic Parts (LEW-17682-1/4-1), Software Tech Briefs supplement to NASA Tech Briefs, Vol. 30, No. 9 (September 2006), page 10. The ANSYS PDS software enables the ANSYS finite-element-analysis program to account for uncertainty in the design-and analysis process. The ANSYS PDS software accounts for uncertainty in material properties, dimensions, and loading by assigning probabilistic distributions to user-specified model parameters and performing simulations using various sampling techniques.

Low melting high lithia glass compositions and methods

DOEpatents

Jantzen, Carol M.; Pickett, John B.; Cicero-Herman, Connie A.; Marra, James C.

2003-09-23

The invention relates to methods of vitrifying waste and for lowering the melting point of glass forming systems by including lithia formers in the glass forming composition in significant amounts, typically from about 0.16 wt % to about 11 wt %, based on the total glass forming oxides. The lithia is typically included as a replacement for alkali oxide glass formers that would normally be present in a particular glass forming system. Replacement can occur on a mole percent or weight percent basis, and typically results in a composition wherein lithia forms about 10 wt % to about 100 wt % of the alkali oxide glass formers present in the composition. The present invention also relates to the high lithia glass compositions formed by these methods. The invention is useful for stabilization of numerous types of waste materials, including aqueous waste uranium oxides The decrease in melting point achieved by the present invention desirably prevents volatilization of hazardous or radioactive species during vitrification.

Aberrations for Grazing Incidence Optics

NASA Technical Reports Server (NTRS)

Saha, Timo T.

2008-01-01

Large number of grazing incidence telescope configurations have been designed and studied. Wolte1 telescopes are commonly used in astronomical applications. Wolter telescopes consist of a paraboloidal primary mirror and a hyperboloidal or an ellipsoidal secondary mirror. There are 8 possible combinations of Wolter telescopes. Out of these possible designs only type 1 and type 2 telescopes are widely used. Type 1 telescope is typically used for x-ray applications and type 2 telescopes are used for EUV applications. Wolter-Schwarzshild (WS) telescopes offer improved image quality over a small field of view. The WS designs are stigmatic and free of third order coma and, therefore, the PSF is significantly better over a small field of view. Typically the image is more symmetric about its centroid. As for the Wolter telescopes there are 8 possible combinations of WS telescopes. These designs have not been widely used because the surface equations are complex parametric equations complicating the analysis and typically the resolution requirements are too low to take full advantage of the WS designs. There are several other design options. Most notable are wide field x-ray telescope designs. Polynomial designs were originally suggested by Burrows4 and hyperboloid-hyperboloid designs for solar physics applications were designed by Harvey5. No general aberration theory exists for grazing incidence telescopes that would cover all the design options. Several authors have studied the aberrations of grazing incidence telescopes. A comprehensive theory of Wolter type 1 and 2 telescopes has been developed. Later this theory was expanded to include all possible combinations of grazing incidence and also normal incidence paraboloid-hyperboloid and paraboloid-ellipsoid telescopes. In this article the aberration theory of Wolter type telescopes is briefly reviewed.

Design Support System for Coloring Illustrations by Using the Colors Preferred by a User as Determined from the Hue Patterns of Illustrations Prepared by that User

NASA Astrophysics Data System (ADS)

Fukai, Hironobu; Mitsukura, Yasue

We propose a new design support system that can color illustrations according to a person's color preferences that are determined on the basis of the color patterns of illustrations prepared by that person. Recently, many design tools for promoting free design have been developed. However, preferences for various colors differ depending on individual personality. Therefore, a system that can automatically color various designs on the basis of human preference is required. In this study, we propose an automatic modeling system that can be used to model illustrations. To verify the effectiveness of the proposed system, we simulate a coloring design experiment to determine the color patterns preferred by some subjects by using various design data. By using the design data, we determine each subjects preferred color pattern, and send feedback on these individual color patterns to the proposed system.

Study on reservoir time-varying design flood of inflow based on Poisson process with time-dependent parameters

NASA Astrophysics Data System (ADS)

Li, Jiqing; Huang, Jing; Li, Jianchang

2018-06-01

The time-varying design flood can make full use of the measured data, which can provide the reservoir with the basis of both flood control and operation scheduling. This paper adopts peak over threshold method for flood sampling in unit periods and Poisson process with time-dependent parameters model for simulation of reservoirs time-varying design flood. Considering the relationship between the model parameters and hypothesis, this paper presents the over-threshold intensity, the fitting degree of Poisson distribution and the design flood parameters are the time-varying design flood unit period and threshold discriminant basis, deduced Longyangxia reservoir time-varying design flood process at 9 kinds of design frequencies. The time-varying design flood of inflow is closer to the reservoir actual inflow conditions, which can be used to adjust the operating water level in flood season and make plans for resource utilization of flood in the basin.

46 CFR 12.13-3 - Basis of documentary evidence.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Basis of documentary evidence. 12.13-3 Section 12.13-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR RATING ENDORSEMENTS Persons Designated To Provide Medical Care on Board Ship § 12.13-3 Basis of documentary evidence. The Officer in Charge,...

46 CFR 12.13-3 - Basis of documentary evidence.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Basis of documentary evidence. 12.13-3 Section 12.13-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR RATING ENDORSEMENTS Persons Designated To Provide Medical Care on Board Ship § 12.13-3 Basis of documentary evidence. The Officer in Charge,...

46 CFR 12.13-3 - Basis of documentary evidence.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Basis of documentary evidence. 12.13-3 Section 12.13-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR RATING ENDORSEMENTS Persons Designated To Provide Medical Care on Board Ship § 12.13-3 Basis of documentary evidence. The Officer in Charge,...

46 CFR 12.13-3 - Basis of documentary evidence.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Basis of documentary evidence. 12.13-3 Section 12.13-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR RATING ENDORSEMENTS Persons Designated To Provide Medical Care on Board Ship § 12.13-3 Basis of documentary evidence. The Officer in Charge,...

Evidence of the preferential use of disease prototypes over case exemplars among early year one medical students prior to and following diagnostic training.

PubMed

Papa, Frank J; Li, Feiming

2015-12-01

Two core dual processing theory (DPT) System I constructs (Exemplars and Prototypes) were used to: 1) formulate a training exercise designed to improve diagnostic performance in year one medical students, and 2) explore whether any observed performance improvements were associated with preferential use of exemplars or prototypes. With IRB approval, 117 year one medical students participated in an acute chest pain diagnostic training exercise. A pre- and post-training test containing the same 27 case vignettes was used to determine if the subjects' diagnostic performance improved via training in both exemplars and prototypes. Exemplar and Prototype theory was also used to generate a unique typicality estimate for each case vignette. Because these estimates produce different performance predictions, differences in the subjects' observed performance would make it possible to infer whether subjects were preferentially using Exemplars or Prototypes. Pre- vs. post-training comparison revealed a significant performance improvement; t=14.04, p<0.001, Cohen's d=1.32. Pre-training, paired t-testing demonstrated that performance against the most typical vignettes>mid typical vignettes: t=4.94, p<0.001; and mid typical>least typical: t=5.16, p<0.001. Post-training, paired t-testing again demonstrated that performance against the most typical vignettes>mid typical: t=2.94, p<0.01; and mid typical>least typical: t=6.64, p<0.001. These findings are more consistent with the performance predictions generated via Prototype theory than Exemplar theory. DPT is useful in designing and evaluating the utility of new approaches to diagnostic training, and, investigating the cognitive factors driving diagnostic capabilities among early medical students.

The Impact of Information Technology on the Design, Development, and Implementation of a Lunar Exploration Mission

NASA Technical Reports Server (NTRS)

Gross, Anthony R.; Sims, Michael H.; Briggs, Geoffrey A.

1996-01-01

From the beginning to the present expeditions to the Moon have involved a large investment of human labor. This has been true for all aspects of the process, from the initial design of the mission, whether scientific or technological, through the development of the instruments and the spacecraft, to the flight and operational phases. In addition to the time constraints that this situation imposes, there is also a significant cost associated with the large labor costs. As a result lunar expeditions have been limited to a few robotic missions and the manned Apollo program missions of the 1970s. With the rapid rise of the new information technologies, new paradigms are emerging that promise to greatly reduce both the time and cost of such missions. With the rapidly increasing capabilities of computer hardware and software systems, as well as networks and communication systems, a new balance of work is being developed between the human and the machine system. This new balance holds the promise of greatly increased exploration capability, along with dramatically reduced design, development, and operating costs. These new information technologies, utilizing knowledge-based software and very highspeed computer systems, will provide new design and development tools, scheduling mechanisms, and vehicle and system health monitoring capabilities that have hitherto been unavailable to the mission and spacecraft designer and the system operator. This paper will utilize typical lunar missions, both robotic and crewed, as a basis to describe and illustrate how these new information system technologies could be applied to all aspects such missions. In particular, new system design tradeoff tools will be described along with technologies that will allow a very much greater degree of autonomy of exploration vehicles than has heretofore been possible. In addition, new information technologies that will significantly reduce the human operational requirements will be discussed.

A Methodology for Quantifying Certain Design Requirements During the Design Phase

NASA Technical Reports Server (NTRS)

Adams, Timothy; Rhodes, Russel

2005-01-01

A methodology for developing and balancing quantitative design requirements for safety, reliability, and maintainability has been proposed. Conceived as the basis of a more rational approach to the design of spacecraft, the methodology would also be applicable to the design of automobiles, washing machines, television receivers, or almost any other commercial product. Heretofore, it has been common practice to start by determining the requirements for reliability of elements of a spacecraft or other system to ensure a given design life for the system. Next, safety requirements are determined by assessing the total reliability of the system and adding redundant components and subsystems necessary to attain safety goals. As thus described, common practice leaves the maintainability burden to fall to chance; therefore, there is no control of recurring costs or of the responsiveness of the system. The means that have been used in assessing maintainability have been oriented toward determining the logistical sparing of components so that the components are available when needed. The process established for developing and balancing quantitative requirements for safety (S), reliability (R), and maintainability (M) derives and integrates NASA s top-level safety requirements and the controls needed to obtain program key objectives for safety and recurring cost (see figure). Being quantitative, the process conveniently uses common mathematical models. Even though the process is shown as being worked from the top down, it can also be worked from the bottom up. This process uses three math models: (1) the binomial distribution (greaterthan- or-equal-to case), (2) reliability for a series system, and (3) the Poisson distribution (less-than-or-equal-to case). The zero-fail case for the binomial distribution approximates the commonly known exponential distribution or "constant failure rate" distribution. Either model can be used. The binomial distribution was selected for modeling flexibility because it conveniently addresses both the zero-fail and failure cases. The failure case is typically used for unmanned spacecraft as with missiles.

Assessing Design Activity in Complex CMOS Circuit Design.

ERIC Educational Resources Information Center

Biswas, Gautam; And Others

This report characterizes human problem solving in digital circuit design. Protocols of 11 different designers with varying degrees of training were analyzed by identifying the designers' problem solving strategies and discussing activity patterns that differentiate the designers. These methods are proposed as a tentative basis for assessing…

“The Mind Is Its Own Place”: Amelioration of Claustrophobia in Semantic Dementia

PubMed Central

Clark, Camilla N.; Downey, Laura E.; Golden, Hannah L.; Fletcher, Phillip D.; Cifelli, Alberto; Warren, Jason D.

2014-01-01

Phobias are among the few intensely fearful experiences we regularly have in our everyday lives, yet the brain basis of phobic responses remains incompletely understood. Here we describe the case of a 71-year-old patient with a typical clinicoanatomical syndrome of semantic dementia led by selective (predominantly right-sided) temporal lobe atrophy, who showed striking amelioration of previously disabling claustrophobia following onset of her cognitive syndrome. We interpret our patient's newfound fearlessness as an interaction of damaged limbic and autonomic responsivity with loss of the cognitive meaning of previously threatening situations. This case has implications for our understanding of brain network disintegration in semantic dementia and the neurocognitive basis of phobias more generally. PMID:24825962

Fluidized-bed copper oxide process. Phase IV. Conceptual design and economic evaluation, Volume I. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-11-30

Universal Oil Products, Inc. (UOP) of Des Plaines, Illinois has contracted A.E. Roberts & Associates, Inc. (AERA) of Atlanta, Georgia to prepare a sensitivity analysis for the development of the Fluidized-bed Copper Oxide (FBCO) process. As proposed by AERA in September 1991, development of the FBCO process design for a 500 mega-watt (MW) unit was divided into three tasks: (1) Establishment of a Conceptual Design, (2) Conceptual Design, (3) Cost Analysis Task 1 determined the basis for a conceptual design for the 500 megawatt (MW) FBCO process. It was completed by AERA in September of 1992, and a report wasmore » submitted at that time {open_quotes}Establishment of the Design Basis for Application to a 500 MW Coal-fired Facility.{close_quotes} Task 2 gathered all pertinent data available to date and reviewed its applicability to the 500 MW FBCO process. Work on this task was carried out on a joint basis by the AERA team members: Roberts & Schaefers worked on the dense phase transport aspect of the design; Cornell and Carnegie Mellon Universities worked on the design kinetics and modeling; and AERA contributed commercial power and combustion experience. Task 3 provides budgetary cost estimates for the FBCO process and competing alternative technologies for sulfur dioxide and nitrogen oxide removal.« less