Progress in Developing Transfer Functions for Surface Scanning Eddy Current Inspections

NASA Astrophysics Data System (ADS)

Shearer, J.; Heebl, J.; Brausch, J.; Lindgren, E.

2009-03-01

As US Air Force (USAF) aircraft continue to age, additional inspections are required for structural components. The validation of new inspections typically requires a capability demonstration of the method using representative structure with representative damage. To minimize the time and cost required to prepare such samples, Electric Discharge machined (EDM) notches are commonly used to represent fatigue cracks in validation studies. However, the sensitivity to damage typically changes as a function of damage type. This requires a mathematical relationship to be developed between the responses from the two different flaw types to enable the use of EDM notched samples to validate new inspections. This paper reviews progress to develop transfer functions for surface scanning eddy current inspections of aluminum and titanium alloys found in structural aircraft components. Multiple samples with well characterized grown fatigue cracks and master gages with EDM notches, both with a range of flaw sizes, were used to collect flaw signals with USAF field inspection equipment. Analysis of this empirical data was used to develop a transfer function between the response from the EDM notches and grown fatigue cracks.

Interference effects of vocalization on dual task performance

NASA Astrophysics Data System (ADS)

Owens, J. M.; Goodman, L. S.; Pianka, M. J.

1984-09-01

Voice command and control systems have been proposed as a potential means of off-loading the typically overburdened visual information processing system. However, prior to introducing novel human-machine interfacing technologies in high workload environments, consideration must be given to the integration of the new technologists within existing task structures to ensure that no new sources of workload or interference are systematically introduced. This study examined the use of voice interactive systems technology in the joint performance of two cognitive information processing tasks requiring continuous memory and choice reaction wherein a basis for intertask interference might be expected. Stimuli for the continuous memory task were presented aurally and either voice or keyboard responding was required in the choice reaction task. Performance was significantly degraded in each task when voice responding was required in the choice reaction time task. Performance degradation was evident in higher error scores for both the choice reaction and continuous memory tasks. Performance decrements observed under conditions of high intertask stimulus similarity were not statistically significant. The results signal the need to consider further the task requirements for verbal short-term memory when applying speech technology in multitask environments.

A method to improve the range resolution in stepped frequency continuous wave radar

NASA Astrophysics Data System (ADS)

Kaczmarek, Paweł

2018-04-01

In the paper one of high range resolution methods - Aperture Sampling - was analysed. Unlike MUSIC based techniques it proved to be very efficient in terms of achieving unambiguous synthetic range profile for ultra-wideband stepped frequency continuous wave radar. Assuming that minimal distance required to separate two targets in depth (distance) corresponds to -3 dB width of received echo, AS provided a 30,8 % improvement in range resolution in analysed scenario, when compared to results of applying IFFT. Output data is far superior in terms of both improved range resolution and reduced side lobe level than used typically in this area Inverse Fourier Transform. Furthermore it does not require prior knowledge or an estimate of number of targets to be detected in a given scan.

Towards a rigorous framework for studying 2-player continuous games.

PubMed

Shutters, Shade T

2013-03-21

The use of 2-player strategic games is one of the most common frameworks for studying the evolution of economic and social behavior. Games are typically played between two players, each given two choices that lie at the extremes of possible behavior (e.g. completely cooperate or completely defect). Recently there has been much interest in studying the outcome of games in which players may choose a strategy from the continuous interval between extremes, requiring the set of two possible choices be replaced by a single continuous equation. This has led to confusion and even errors in the classification of the game being played. The issue is described here specifically in relation to the continuous prisoners dilemma and the continuous snowdrift game. A case study is then presented demonstrating the misclassification that can result from the extension of discrete games into continuous space. The paper ends with a call for a more rigorous and clear framework for working with continuous games. Copyright © 2013 Elsevier Ltd. All rights reserved.

Steerable vertical to horizontal energy transducer for mobile robots

DOEpatents

Spletzer, Barry L.; Fischer, Gary J.; Feddema, John T.

2001-01-01

The present invention provides a steerable vertical to horizontal energy transducer for mobile robots that less complex and requires less power than two degree of freedom tilt mechanisms. The present invention comprises an end effector that, when mounted with a hopping actuator, translates along axis (typically vertical) actuation into combined vertical and horizontal motion. The end effector, or foot, mounts with an end of the actuator that moves toward the support surface (typically a floor or the earth). The foot is shaped so that the first contact with the support surface is off the axis of the actuator. Off-axis contact with the support surface generates an on-axis force (typically resulting in vertical motion) and a moment orthogonal to the axis. The moment initiates a horizontal tumbling motion, and tilts the actuator so that its axis is oriented with a horizontal component and continued actuation generates both vertical and horizontal force.

SmallSat Precision Navigation with Low-Cost MEMS IMU Swarms

NASA Technical Reports Server (NTRS)

Christian, John; Bishop, Robert; Martinez, Andres; Petro, Andrew

2015-01-01

The continued advancement of small satellite-based science missions requires the solution to a number of important technical challenges. Of particular note is that small satellite missions are characterized by tight constraints on cost, mass, power, and volume that make them unable to fly the high-quality Inertial Measurement Units (IMUs) required for orbital missions demanding precise orientation and positioning. Instead, small satellite missions typically fly low-cost Micro-Electro-Mechanical System (MEMS) IMUs. Unfortunately, the performance characteristics of these MEMS IMUs make them ineffectual in many spaceflight applications when employed in a single IMU system configuration.

Spectral Processing Analysis System (SPANS).

DTIC Science & Technology

1980-11-01

Approximately 750 pounds Temperature Range: 60 - 80 degrees Farenheit Humidity: 40 - 70 percent (relative) Duty Cycle: Continuous Power Requirements: 5 wire, 3...displayed per display frame, local or absolute scaling, number of display points per line and waveform av- A eraging. A typical display is shown in Figure 3...the waveform. In the case of white noise, a high degree of correlation is found at zero lag only with the remaining lags showing little correlation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schreiber, J.; Max-Planck-Institut für Quantenoptik Garching, Hans-Kopfermann-Str. 1, 85748 Garching bei München; Bolton, P. R.

An overview of progress and typical yields from intense laser-plasma acceleration of ions is presented. The evolution of laser-driven ion acceleration at relativistic intensities ushers prospects for improved functionality and diverse applications which can represent a varied assortment of ion beam requirements. This mandates the development of the integrated laser-driven ion accelerator system, the multiple components of which are described. Relevant high field laser-plasma science and design of controlled optimum pulsed laser irradiation on target are dominant single shot (pulse) considerations with aspects that are appropriate to the emerging petawatt era. The pulse energy scaling of maximum ion energies andmore » typical differential spectra obtained over the past two decades provide guidance for continued advancement of laser-driven energetic ion sources and their meaningful applications.« less

Children's need for favorable acoustics in schools

NASA Astrophysics Data System (ADS)

Nelson, Peggy B.

2003-10-01

Children continue to improve their understanding of speech in noise and reverberation throughout childhood and adolescence. They do not typically achieve adult performance levels until their late teenage years. As a result, schools that are designed to be acoustically adequate for adult understanding may be insufficient for full understanding by young children. In addition, children with hearing loss, those with attention problems, and those learning in a non-native language require even more favorable signal-to-noise ratios. This tutorial will review the literature gathered by the ANSl/ASA working group on classroom acoustics that shaped the recommendations of the working group. Special topics will include speech perception data from typically developing infants and children, from children with hearing loss, and from adults and children listening in a non-native language. In addition, the tutorial will overview recommendations contained within ANSI standard 12.60-2002: Acoustical Performance Criteria, Design Requirements, and Guidelines for Schools. The discussion will also include issues related to designing quiet classrooms and working with local schools and professionals.

Continuous Codes and Standards Improvement (CCSI)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rivkin, Carl H; Burgess, Robert M; Buttner, William J

2015-10-21

As of 2014, the majority of the codes and standards required to initially deploy hydrogen technologies infrastructure in the United States have been promulgated. These codes and standards will be field tested through their application to actual hydrogen technologies projects. Continuous codes and standards improvement (CCSI) is a process of identifying code issues that arise during project deployment and then developing codes solutions to these issues. These solutions would typically be proposed amendments to codes and standards. The process is continuous because as technology and the state of safety knowledge develops there will be a need to monitor the applicationmore » of codes and standards and improve them based on information gathered during their application. This paper will discuss code issues that have surfaced through hydrogen technologies infrastructure project deployment and potential code changes that would address these issues. The issues that this paper will address include (1) setback distances for bulk hydrogen storage, (2) code mandated hazard analyses, (3) sensor placement and communication, (4) the use of approved equipment, and (5) system monitoring and maintenance requirements.« less

Robustness of quantum key distribution with discrete and continuous variables to channel noise

NASA Astrophysics Data System (ADS)

Lasota, Mikołaj; Filip, Radim; Usenko, Vladyslav C.

2017-06-01

We study the robustness of quantum key distribution protocols using discrete or continuous variables to the channel noise. We introduce the model of such noise based on coupling of the signal to a thermal reservoir, typical for continuous-variable quantum key distribution, to the discrete-variable case. Then we perform a comparison of the bounds on the tolerable channel noise between these two kinds of protocols using the same noise parametrization, in the case of implementation which is perfect otherwise. Obtained results show that continuous-variable protocols can exhibit similar robustness to the channel noise when the transmittance of the channel is relatively high. However, for strong loss discrete-variable protocols are superior and can overcome even the infinite-squeezing continuous-variable protocol while using limited nonclassical resources. The requirement on the probability of a single-photon production which would have to be fulfilled by a practical source of photons in order to demonstrate such superiority is feasible thanks to the recent rapid development in this field.

Multiplexed chemostat system for quantification of biodiversity and ecosystem functioning in anaerobic digestion

PubMed Central

Plouchart, Diane; Guizard, Guillaume; Latrille, Eric

2018-01-01

Continuous cultures in chemostats have proven their value in microbiology, microbial ecology, systems biology and bioprocess engineering, among others. In these systems, microbial growth and ecosystem performance can be quantified under stable and defined environmental conditions. This is essential when linking microbial diversity to ecosystem function. Here, a new system to test this link in anaerobic, methanogenic microbial communities is introduced. Rigorously replicated experiments or a suitable experimental design typically require operating several chemostats in parallel. However, this is labor intensive, especially when measuring biogas production. Commercial solutions for multiplying reactors performing continuous anaerobic digestion exist but are expensive and use comparably large reactor volumes, requiring the preparation of substantial amounts of media. Here, a flexible system of Lab-scale Automated and Multiplexed Anaerobic Chemostat system (LAMACs) with a working volume of 200 mL is introduced. Sterile feeding, biomass wasting and pressure monitoring are automated. One module containing six reactors fits the typical dimensions of a lab bench. Thanks to automation, time required for reactor operation and maintenance are reduced compared to traditional lab-scale systems. Several modules can be used together, and so far the parallel operation of 30 reactors was demonstrated. The chemostats are autoclavable. Parameters like reactor volume, flow rates and operating temperature can be freely set. The robustness of the system was tested in a two-month long experiment in which three inocula in four replicates, i.e., twelve continuous digesters were monitored. Statistically significant differences in the biogas production between inocula were observed. In anaerobic digestion, biogas production and consequently pressure development in a closed environment is a proxy for ecosystem performance. The precision of the pressure measurement is thus crucial. The measured maximum and minimum rates of gas production could be determined at the same precision. The LAMACs is a tool that enables us to put in practice the often-demanded need for replication and rigorous testing in microbial ecology as well as bioprocess engineering. PMID:29518106

BLOND, a building-level office environment dataset of typical electrical appliances.

PubMed

Kriechbaumer, Thomas; Jacobsen, Hans-Arno

2018-03-27

Energy metering has gained popularity as conventional meters are replaced by electronic smart meters that promise energy savings and higher comfort levels for occupants. Achieving these goals requires a deeper understanding of consumption patterns to reduce the energy footprint: load profile forecasting, power disaggregation, appliance identification, startup event detection, etc. Publicly available datasets are used to test, verify, and benchmark possible solutions to these problems. For this purpose, we present the BLOND dataset: continuous energy measurements of a typical office environment at high sampling rates with common appliances and load profiles. We provide voltage and current readings for aggregated circuits and matching fully-labeled ground truth data (individual appliance measurements). The dataset contains 53 appliances (16 classes) in a 3-phase power grid. BLOND-50 contains 213 days of measurements sampled at 50kSps (aggregate) and 6.4kSps (individual appliances). BLOND-250 consists of the same setup: 50 days, 250kSps (aggregate), 50kSps (individual appliances). These are the longest continuous measurements at such high sampling rates and fully-labeled ground truth we are aware of.

BLOND, a building-level office environment dataset of typical electrical appliances

NASA Astrophysics Data System (ADS)

Kriechbaumer, Thomas; Jacobsen, Hans-Arno

2018-03-01

Energy metering has gained popularity as conventional meters are replaced by electronic smart meters that promise energy savings and higher comfort levels for occupants. Achieving these goals requires a deeper understanding of consumption patterns to reduce the energy footprint: load profile forecasting, power disaggregation, appliance identification, startup event detection, etc. Publicly available datasets are used to test, verify, and benchmark possible solutions to these problems. For this purpose, we present the BLOND dataset: continuous energy measurements of a typical office environment at high sampling rates with common appliances and load profiles. We provide voltage and current readings for aggregated circuits and matching fully-labeled ground truth data (individual appliance measurements). The dataset contains 53 appliances (16 classes) in a 3-phase power grid. BLOND-50 contains 213 days of measurements sampled at 50kSps (aggregate) and 6.4kSps (individual appliances). BLOND-250 consists of the same setup: 50 days, 250kSps (aggregate), 50kSps (individual appliances). These are the longest continuous measurements at such high sampling rates and fully-labeled ground truth we are aware of.

BLOND, a building-level office environment dataset of typical electrical appliances

PubMed Central

Kriechbaumer, Thomas; Jacobsen, Hans-Arno

2018-01-01

Energy metering has gained popularity as conventional meters are replaced by electronic smart meters that promise energy savings and higher comfort levels for occupants. Achieving these goals requires a deeper understanding of consumption patterns to reduce the energy footprint: load profile forecasting, power disaggregation, appliance identification, startup event detection, etc. Publicly available datasets are used to test, verify, and benchmark possible solutions to these problems. For this purpose, we present the BLOND dataset: continuous energy measurements of a typical office environment at high sampling rates with common appliances and load profiles. We provide voltage and current readings for aggregated circuits and matching fully-labeled ground truth data (individual appliance measurements). The dataset contains 53 appliances (16 classes) in a 3-phase power grid. BLOND-50 contains 213 days of measurements sampled at 50kSps (aggregate) and 6.4kSps (individual appliances). BLOND-250 consists of the same setup: 50 days, 250kSps (aggregate), 50kSps (individual appliances). These are the longest continuous measurements at such high sampling rates and fully-labeled ground truth we are aware of. PMID:29583141

Architecture Study on Telemetry Coverage for Immediate Post-Separation Phase

NASA Technical Reports Server (NTRS)

Cheung, Kar-Ming; Lee, Charles H.; Kellogg, Kent H.; Stocklin, Frank J.; Zillig, David J.; Fielhauer, Karl B.

2008-01-01

This paper presents the preliminary results of an architecture study that provides continuous telemetry coverage for NASA missions for immediate post-separation phase. This study is a collaboration effort between Jet Propulsion Laboratory (JPL), Goddard Space Flight Center (GSFC), and Applied Physics Laboratory (APL). After launch when the spacecraft separated from the upper stage, the spacecraft typically executes a number of mission-critical operations prior to the deployment of solar panels and the activation of the primary communication subsystem. JPL, GSFC, and APL have similar design principle statements that require continuous coverage of mission-critical telemetry during the immediate post-separation phase. To conform to these design principles, an architecture that consists of a separate spacecraft transmitter and a robust communication network capable of tracking the spacecraft signals is needed.This paper presents the preliminary results of an architecture study that provides continuous telemetry coverage for NASA missions for immediate post-separation phase. This study is a collaboration effort between Jet Propulsion Laboratory (JPL), Goddard Space Flight Center (GSFC), and Applied Physics Laboratory (APL). After launch when the spacecraft separated from the upper stage, the spacecraft typically executes a number of mission-critical operations prior to the deployment of solar panels and the activation of the primary communication subsystem. JPL, GSFC, and APL have similar design principle statements that require continuous coverage of mission-critical telemetry during the immediate post-separation phase. To conform to these design principles, an architecture that consists of a separate spacecraft transmitter and a robust communication network capable of tracking the spacecraft signals is needed. The main results of this study are as follows: 1) At low altitude (< 10000 km) when most post-separation critical operations are executed, Earth-based network (e.g. Deep Space Network (DSN)) can only provide limited coverage, whereas space-based network (e.g. Space Network (SN)) can provide continuous coverage. 2) Commercial-off-the-shelf SN compatible transmitters are available for small satellite applications. In this paper we present the detailed coverage analysis of Earth-based and Space-based networks. We identify the key functional and performance requirements of the architecture, and describe the proposed selection criteria of the spacecraft transmitter. We conclude the paper with a proposed forward plan.

Age-Related Brain Activation Changes during Rule Repetition in Word-Matching.

PubMed

Methqal, Ikram; Pinsard, Basile; Amiri, Mahnoush; Wilson, Maximiliano A; Monchi, Oury; Provost, Jean-Sebastien; Joanette, Yves

2017-01-01

Objective: The purpose of this study was to explore the age-related brain activation changes during a word-matching semantic-category-based task, which required either repeating or changing a semantic rule to be applied. In order to do so, a word-semantic rule-based task was adapted from the Wisconsin Sorting Card Test, involving the repeated feedback-driven selection of given pairs of words based on semantic category-based criteria. Method: Forty healthy adults (20 younger and 20 older) performed a word-matching task while undergoing a fMRI scan in which they were required to pair a target word with another word from a group of three words. The required pairing is based on three word-pair semantic rules which correspond to different levels of semantic control demands: functional relatedness, moderately typical-relatedness (which were considered as low control demands), and atypical-relatedness (high control demands). The sorting period consisted of a continuous execution of the same sorting rule and an inferred trial-by-trial feedback was given. Results: Behavioral performance revealed increases in response times and decreases of correct responses according to the level of semantic control demands (functional vs. typical vs. atypical) for both age groups (younger and older) reflecting graded differences in the repetition of the application of a given semantic rule. Neuroimaging findings of significant brain activation showed two main results: (1) Greater task-related activation changes for the repetition of the application of atypical rules relative to typical and functional rules, and (2) Changes (older > younger) in the inferior prefrontal regions for functional rules and more extensive and bilateral activations for typical and atypical rules. Regarding the inter-semantic rules comparison, only task-related activation differences were observed for functional > typical (e.g., inferior parietal and temporal regions bilaterally) and atypical > typical (e.g., prefrontal, inferior parietal, posterior temporal, and subcortical regions). Conclusion: These results suggest that healthy cognitive aging relies on the adaptive changes of inferior prefrontal resources involved in the repetitive execution of semantic rules, thus reflecting graded differences in support of task demands.

Planning continuing training.

PubMed

Nacef, T; Argellies, J L

1982-01-01

Suggests new direction in the approach to planning continued training of medical personnel. Under this new scheme, health problems themselves will be the sole basis for the planning of the continuing training program. This approach assures the involvement of health professionals at various levels and fosters a multiprofessional involvement in continuing training. It is also recommended that the preventive aspects of medicine be stressed far more than is typical of traditional hospital services. The method for decision making in program planning includes 6 steps: 1) choice of health problem to be solved (includes considerations of severity of the problems and the degree to which continuing training will be of value); 2) analysis of the number and type of health personnel needed; 3) determination of desired skill acquisition; 4) analysis of teaching/educational requirements; 5) inventory of resources (time, facilities, staff, instructional materials) available; 6) evaluation. Coordination at different levels, both national and regional, ensures the cohesion of the multiprofessional continuing training system. Regional cell groups, composed of 2 paramedicals and a doctor administer continuing training sessions under policy established at a national level by a national advisory committee. This approach makes continuing training an important and immediate component of health policy aimed at delivering basic health services to the entire population.

Research on Soft Reduction Amount Distribution to Eliminate Typical Inter-dendritic Crack in Continuous Casting Slab of X70 Pipeline Steel by Numerical Model

NASA Astrophysics Data System (ADS)

Liu, Ke; Wang, Chang; Liu, Guo-liang; Ding, Ning; Sun, Qi-song; Tian, Zhi-hong

2017-04-01

To investigate the formation of one kind of typical inter-dendritic crack around triple point region in continuous casting(CC) slab during the operation of soft reduction, fully coupled 3D thermo-mechanical finite element models was developed, also plant trials were carried out in a domestic continuous casting machine. Three possible types of soft reduction amount distribution (SRAD) in the soft reduction region were analyzed. The relationship between the typical inter-dendritic cracks and soft reduction conditions is presented and demonstrated in production practice. Considering the critical strain of internal crack formation, a critical tolerance for the soft reduction amount distribution and related casing parameters have been proposed for better contribution of soft reduction to the internal quality of slabs. The typical inter-dendritic crack around the triple point region had been eliminated effectively through the application of proposed suggestions for continuous casting of X70 pipeline steel in industrial practice.

Coverage and control of constellations of elliptical inclined frozen lunar orbits

NASA Technical Reports Server (NTRS)

Ely, Todd A.

2005-01-01

A great deal of scientific interest exists regarding the permanently shadowed craters near the poles of the Moon where there may be frozen volatiles. These regions, particularly the Moon's South Pole, have been proposed for extensive robotic and human exploration. Unfortunately, they are typically not in view of Earth, and would require some form of communication relay to facilitate exploration via robotic and/or human missions. One solution for such a relay is a long-lived constellation of lunar telecommunication orbiters providing focused coverage at the pole of interest. Robust support requires this coverage to be continuous, redundant, and, in order to minimize costs, this constellation should consist of 3 satellites or fewer.

Volcanic eruptions on Io - Implications for surface evolution and mass loss

NASA Technical Reports Server (NTRS)

Johnson, T. V.; Soderblom, L. A.

1982-01-01

Active volcanism on Io results in a continual resurfacing of the satellite. Analysis of required burial rates to erase impact craters, the mass production in the observed plumes, and the energy requirements for the volcanic activity suggest resurfacing rates of 0.001 to 10 cm/yr in recent geologic time. If this rate is typical of the last 4.5 Gyr, then extensive recycling of the upper crust and mantle must have occurred. The currently estimated loss rate of S, O, and Na from Io into the magnetosphere corresponds to only a small fraction of the resurfacing rate and should not have resulted in either extensive erosion or total depletion of any of the escaping species.

Contamination control requirements implementation for the James Webb Space Telescope (JWST), part 2: spacecraft, sunshield, observatory, and launch

NASA Astrophysics Data System (ADS)

Wooldridge, Eve M.; Schweiss, Andrea; Henderson-Nelson, Kelly; Woronowicz, Michael; Patel, Jignasha; Macias, Matthew; McGregor, R. Daniel; Farmer, Greg; Schmeitzky, Olivier; Jensen, Peter; Rumler, Peter; Romero, Beatriz; Breton, Jacques

2014-09-01

This paper will continue from Part 1 of JWST contamination control implementation. In addition to optics, instruments, and thermal vacuum testing, JWST also requires contamination control for a spacecraft that must be vented carefully in order to maintain solar array and thermal radiator thermal properties; a tennis court-sized sunshield made with 1-2 mil Kapton™ layers that must be manufactured and maintained clean; an observatory that must be integrated, stowed and transported to South America; and a rocket that typically launches commercial payloads without contamination sensitivity. An overview of plans developed to implement contamination control for the JWST spacecraft, sunshield, observatory and launch vehicle will be presented.

Fault-tolerant feature-based estimation of space debris rotational motion during active removal missions

NASA Astrophysics Data System (ADS)

Biondi, Gabriele; Mauro, Stefano; Pastorelli, Stefano; Sorli, Massimo

2018-05-01

One of the key functionalities required by an Active Debris Removal mission is the assessment of the target kinematics and inertial properties. Passive sensors, such as stereo cameras, are often included in the onboard instrumentation of a chaser spacecraft for capturing sequential photographs and for tracking features of the target surface. A plenty of methods, based on Kalman filtering, are available for the estimation of the target's state from feature positions; however, to guarantee the filter convergence, they typically require continuity of measurements and the capability of tracking a fixed set of pre-defined features of the object. These requirements clash with the actual tracking conditions: failures in feature detection often occur and the assumption of having some a-priori knowledge about the shape of the target could be restrictive in certain cases. The aim of the presented work is to propose a fault-tolerant alternative method for estimating the angular velocity and the relative magnitudes of the principal moments of inertia of the target. Raw data regarding the positions of the tracked features are processed to evaluate corrupted values of a 3-dimentional parameter which entirely describes the finite screw motion of the debris and which primarily is invariant on the particular set of considered features of the object. Missing values of the parameter are completely restored exploiting the typical periodicity of the rotational motion of an uncontrolled satellite: compressed sensing techniques, typically adopted for recovering images or for prognostic applications, are herein used in a completely original fashion for retrieving a kinematic signal that appears sparse in the frequency domain. Due to its invariance about the features, no assumptions are needed about the target's shape and continuity of the tracking. The obtained signal is useful for the indirect evaluation of an attitude signal that feeds an unscented Kalman filter for the estimation of the global rotational state of the target. The results of the computer simulations showed a good robustness of the method and its potential applicability for general motion conditions of the target.

Smashing the Stovepipe: Leveraging the GMSEC Open Architecture and Advanced IT Automation to Rapidly Prototype, Develop and Deploy Next-Generation Multi-Mission Ground Systems

NASA Technical Reports Server (NTRS)

Swenson, Paul

2017-01-01

Satellite/Payload Ground Systems - Typically highly-customized to a specific mission's use cases - Utilize hundreds (or thousands!) of specialized point-to-point interfaces for data flows / file transfers Documentation and tracking of these complex interfaces requires extensive time to develop and extremely high staffing costs Implementation and testing of these interfaces are even more cost-prohibitive, and documentation often lags behind implementation resulting in inconsistencies down the road With expanding threat vectors, IT Security, Information Assurance and Operational Security have become key Ground System architecture drivers New Federal security-related directives are generated on a daily basis, imposing new requirements on current / existing ground systems - These mandated activities and data calls typically carry little or no additional funding for implementation As a result, Ground System Sustaining Engineering groups and Information Technology staff continually struggle to keep up with the rolling tide of security Advancing security concerns and shrinking budgets are pushing these large stove-piped ground systems to begin sharing resources - I.e. Operational / SysAdmin staff, IT security baselines, architecture decisions or even networks / hosting infrastructure Refactoring these existing ground systems into multi-mission assets proves extremely challenging due to what is typically very tight coupling between legacy components As a result, many "Multi-Mission" ops. environments end up simply sharing compute resources and networks due to the difficulty of refactoring into true multi-mission systems Utilizing continuous integration / rapid system deployment technologies in conjunction with an open architecture messaging approach allows System Engineers and Architects to worry less about the low-level details of interfaces between components and configuration of systems GMSEC messaging is inherently designed to support multi-mission requirements, and allows components to aggregate data across multiple homogeneous or heterogeneous satellites or payloads - The highly-successful Goddard Science and Planetary Operations Control Center (SPOCC) utilizes GMSEC as the hub for it's automation and situational awareness capability Shifts focus towards getting GS to a final configuration-managed baseline, as well as multi-mission / big-picture capabilities that help increase situational awareness, promote cross-mission sharing and establish enhanced fleet management capabilities across all levels of the enterprise.

Financing maneuvers. Two opportunities to boost a hospital's working capital.

PubMed

Ferconio, S; Lane, M R

1991-10-01

Two receivables financing approaches, factoring and asset-backed securitization, offer an initial cash flow boost and a predictable source for continual cash flow. In a typical receivables factoring program, a healthcare organization receives advance funding from its receivables and reduces collection and follow-up efforts required of its staff. In exchange, the organization: Sells receivables at a discount between 5 percent and 10 percent off face value; and Pays a factoring fee of up to 20 percent of sold receivables. In a typical asset-backed securitization: Proceeds generated from the sale of A1-rated commercial paper are used to purchase receivables from a hospital; Accounts receivable eligible for sale are advance-funded at a level between 80 and 90 percent, with the unfunded portion remaining an asset of the hospital; The hospital is responsible for collection and follow-up activities; and An asset manager maintains cash collections to retire commercial paper notes and pay administrative costs. A healthcare organization interested in receivables financing should review each option's structure and benefits to assess advance funding provided, costs, a seller's level of control, and program eligibility requirements.

Pathwise upper semi-continuity of random pullback attractors along the time axis

NASA Astrophysics Data System (ADS)

Cui, Hongyong; Kloeden, Peter E.; Wu, Fuke

2018-07-01

The pullback attractor of a non-autonomous random dynamical system is a time-indexed family of random sets, typically having the form {At(ṡ) } t ∈ R with each At(ṡ) a random set. This paper is concerned with the nature of such time-dependence. It is shown that the upper semi-continuity of the mapping t ↦At(ω) for each ω fixed has an equivalence relationship with the uniform compactness of the local union ∪s∈IAs(ω) , where I ⊂ R is compact. Applied to a semi-linear degenerate parabolic equation with additive noise and a wave equation with multiplicative noise we show that, in order to prove the above locally uniform compactness and upper semi-continuity, no additional conditions are required, in which sense the two properties appear to be general properties satisfied by a large number of real models.

Product differentiation during continuous-flow thermal gradient PCR.

PubMed

Crews, Niel; Wittwer, Carl; Palais, Robert; Gale, Bruce

2008-06-01

A continuous-flow PCR microfluidic device was developed in which the target DNA product can be detected and identified during its amplification. This in situ characterization potentially eliminates the requirement for further post-PCR analysis. Multiple small targets have been amplified from human genomic DNA, having sizes of 108, 122, and 134 bp. With a DNA dye in the PCR mixture, the amplification and unique melting behavior of each sample is observed from a single fluorescent image. The melting behavior of the amplifying DNA, which depends on its molecular composition, occurs spatially in the thermal gradient PCR device, and can be observed with an optical resolution of 0.1 degrees C pixel(-1). Since many PCR cycles are within the field of view of the CCD camera, melting analysis can be performed at any cycle that contains a significant quantity of amplicon, thereby eliminating the cycle-selection challenges typically associated with continuous-flow PCR microfluidics.

Frequency-duration analysis of dissolved-oxygen concentrations in two southwestern Wisconsin streams

USGS Publications Warehouse

Greb, Steven R.; Graczyk, David J.

2007-01-01

Historically, dissolved-oxygen (DO) data have been collected in the same manner as other water-quality constituents, typically at infrequent intervals as a grab sample or an instantaneous meter reading. Recent years have seen an increase in continuous water-quality monitoring with electronic dataloggers. This new technique requires new approaches in the statistical analysis of the continuous record. This paper presents an application of frequency-duration analysis to the continuous DO records of a cold and a warm water stream in rural southwestern Wisconsin. This method offers a quick, concise way to summarize large time-series data bases in an easily interpretable manner. Even though the two streams had similar mean DO concentrations, frequency-duration analyses showed distinct differences in their DO-concentration regime. This type of analysis also may be useful in relating DO concentrations to biological effects and in predicting low DO occurrences.

Fanconi's anemia. A family study with 20-year follow-up including associated breast pathology.

PubMed

Jacobs, P; Karabus, C

1984-11-01

A brother and sister with Fanconi's anemia, having typical skeletal deformity and characteristic chromosomal breaks in their lymphocytes and who followed the typical clinical course, with progressive bone marrow insufficiency beginning late in the first decade, are described. The natural history of the disease before chemotherapy was available is contrasted with the response to intermittent courses of anabolic steroids during a continuous 20-year follow-up. The female patient developed a carcinoma of the breast at the age of 26, from which she died 5 years later. This neoplasm may reflect increased susceptibility of cells with proven chromosomal abnormality to the influence of carcinogens. Her brother required repeated surgery for painful, but benign, breast masses. The explanation for the latter lesion is unknown but may be related to endocrine disturbances occurring in patients with Fanconi's anemia.

Continuous Particulate Filter State of Health Monitoring Using Radio Frequency Sensing

DOE PAGES

Sappok, Alexander; Ragaller, Paul; Herman, Andrew; ...

2018-04-03

Reliable means for on-board detection of particulate filter failures or malfunctions are needed to meet diagnostics (OBD) requirements. Detecting these failures, which result in tailpipe particulate matter (PM) emissions exceeding the OBD limit, over all operating conditions is challenging. Current approaches employ differential pressure sensors and downstream PM sensors, in combination with particulate filter and engine-out soot models. These conventional monitors typically operate over narrowly-defined time windows and do not provide a direct measure of the filter’s state of health. In contrast, radio frequency (RF) sensors, which transmit a wireless signal through the filter substrate provide a direct means formore » interrogating the condition of the filter itself. Here, this study investigated the use of RF sensors for the continuous measurement of filter trapping efficiency, which was compared to downstream measurements with an AVL Microsoot Sensor, and a PM sampling probe simulating the geometry and installation configuration of a conventional PM sensor. The study included several particulate filter failure modes, both above and below the OBD threshold. Finally, the results confirmed the use of RF sensors to provide a direct and continuous measure of the particulate filter’s state of health over a range of typical in-use operating conditions, thereby significantly increasing the time window over which filter failures may be detected.« less

Continuous Particulate Filter State of Health Monitoring Using Radio Frequency Sensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sappok, Alexander; Ragaller, Paul; Herman, Andrew

Reliable means for on-board detection of particulate filter failures or malfunctions are needed to meet diagnostics (OBD) requirements. Detecting these failures, which result in tailpipe particulate matter (PM) emissions exceeding the OBD limit, over all operating conditions is challenging. Current approaches employ differential pressure sensors and downstream PM sensors, in combination with particulate filter and engine-out soot models. These conventional monitors typically operate over narrowly-defined time windows and do not provide a direct measure of the filter’s state of health. In contrast, radio frequency (RF) sensors, which transmit a wireless signal through the filter substrate provide a direct means formore » interrogating the condition of the filter itself. Here, this study investigated the use of RF sensors for the continuous measurement of filter trapping efficiency, which was compared to downstream measurements with an AVL Microsoot Sensor, and a PM sampling probe simulating the geometry and installation configuration of a conventional PM sensor. The study included several particulate filter failure modes, both above and below the OBD threshold. Finally, the results confirmed the use of RF sensors to provide a direct and continuous measure of the particulate filter’s state of health over a range of typical in-use operating conditions, thereby significantly increasing the time window over which filter failures may be detected.« less

Multivariate statistical monitoring as applied to clean-in-place (CIP) and steam-in-place (SIP) operations in biopharmaceutical manufacturing.

PubMed

Roy, Kevin; Undey, Cenk; Mistretta, Thomas; Naugle, Gregory; Sodhi, Manbir

2014-01-01

Multivariate statistical process monitoring (MSPM) is becoming increasingly utilized to further enhance process monitoring in the biopharmaceutical industry. MSPM can play a critical role when there are many measurements and these measurements are highly correlated, as is typical for many biopharmaceutical operations. Specifically, for processes such as cleaning-in-place (CIP) and steaming-in-place (SIP, also known as sterilization-in-place), control systems typically oversee the execution of the cycles, and verification of the outcome is based on offline assays. These offline assays add to delays and corrective actions may require additional setup times. Moreover, this conventional approach does not take interactive effects of process variables into account and cycle optimization opportunities as well as salient trends in the process may be missed. Therefore, more proactive and holistic online continued verification approaches are desirable. This article demonstrates the application of real-time MSPM to processes such as CIP and SIP with industrial examples. The proposed approach has significant potential for facilitating enhanced continuous verification, improved process understanding, abnormal situation detection, and predictive monitoring, as applied to CIP and SIP operations. © 2014 American Institute of Chemical Engineers.

Power Sources for Micro-Autonomous Vehicles- Challenges and Prospects

NASA Technical Reports Server (NTRS)

Narayan, S. R.; Kisor, A.; Valdez, T. I.; Manohara, H.

2009-01-01

Micro-autonomous vehicle systems are expected to have expanded role in military missions by providing full spectrum intelligence, surveillance and reconnaissance support on the battlefield, suppression of enemy defenses, and enabling co-operative (swarm-like) configurations. Of the numerous demanding requirements of autonomy, sensing, navigation, mobility, etc., meeting the requirement of mission duration or endurance is a very challenging one. This requirement is demanding because of the constraints of mass and volume that limit the quantity of energy that can be stored on-board. Energy is required for mobility, payload operation, information processing, and communication. Mobility requirements typically place an extraordinary demand on the specific energy (Wh/kg) and specific power (W/kg) of the power source; the actual distribution of the energy between mobility and other system functions could vary substantially with the mission type. The power requirements for continuous mobility can vary from 100-1000 W/kg depending on the terrain, ground speed and flight speed. Even with the power source accounting for 30% of the mass of the vehicle, the best of rechargeable batteries can provide only up to 1-2 hours of run-time for a continuous power demand at 100W/kg. In the case of micro-aerial vehicles with flight speed requirements in the range of 5-15 m s-1, the mission times rarely exceed 20 minutes [2]. Further, the power required during take-off and hover can be twice or thrice that needed for steady level flight, and thus the number and sequence of such events is also limited by the mass and size of the power source. For operations such as "perch and stare" or "silent watch" the power demand is often only a tenth of that required during continuous flight. Thus, variation in power demand during various phases of the mission importantly affects the power source selection.

Exercise Induced Rhabdomyolysis with Compartment Syndrome and Renal Failure

PubMed Central

Bhalla, Mary Colleen; Dick-Perez, Ryan

2014-01-01

Exertional rhabdomyolysis is sequela that is occasionally seen after strenuous exercise. The progression to compartment syndrome or renal failure is a rare complication that requires prompt recognition and treatment to prevent morbidity (Giannoglou et al. 2007). We present a case of a 22-year-old college football player who presented to the emergency department (ED) after a typical leg workout as part of his weight conditioning. He was found to have rhabdomyolysis with evidence of renal insufficiency. His condition progressed to bilateral compartment syndrome and renal failure requiring dialysis. After bilateral fasciotomies were performed he had resolution of his compartment syndrome. He continued to be dialysis dependent and had no return of his renal function at discharge 12 days after admission. PMID:25105034

Exercise induced rhabdomyolysis with compartment syndrome and renal failure.

PubMed

Bhalla, Mary Colleen; Dick-Perez, Ryan

2014-01-01

Exertional rhabdomyolysis is sequela that is occasionally seen after strenuous exercise. The progression to compartment syndrome or renal failure is a rare complication that requires prompt recognition and treatment to prevent morbidity (Giannoglou et al. 2007). We present a case of a 22-year-old college football player who presented to the emergency department (ED) after a typical leg workout as part of his weight conditioning. He was found to have rhabdomyolysis with evidence of renal insufficiency. His condition progressed to bilateral compartment syndrome and renal failure requiring dialysis. After bilateral fasciotomies were performed he had resolution of his compartment syndrome. He continued to be dialysis dependent and had no return of his renal function at discharge 12 days after admission.

A toolbox for safety instrumented system evaluation based on improved continuous-time Markov chain

NASA Astrophysics Data System (ADS)

Wardana, Awang N. I.; Kurniady, Rahman; Pambudi, Galih; Purnama, Jaka; Suryopratomo, Kutut

2017-08-01

Safety instrumented system (SIS) is designed to restore a plant into a safe condition when pre-hazardous event is occur. It has a vital role especially in process industries. A SIS shall be meet with safety requirement specifications. To confirm it, SIS shall be evaluated. Typically, the evaluation is calculated by hand. This paper presents a toolbox for SIS evaluation. It is developed based on improved continuous-time Markov chain. The toolbox supports to detailed approach of evaluation. This paper also illustrates an industrial application of the toolbox to evaluate arch burner safety system of primary reformer. The results of the case study demonstrates that the toolbox can be used to evaluate industrial SIS in detail and to plan the maintenance strategy.

Defect printability for high-exposure dose advanced packaging applications

NASA Astrophysics Data System (ADS)

Mikles, Max; Flack, Warren; Nguyen, Ha-Ai; Schurz, Dan

2003-12-01

Pellicles are used in semiconductor lithography to minimize printable defects and reduce reticle cleaning frequency. However, there are a growing number of microlithography applications, such as advanced packaging and nanotechnology, where it is not clear that pellicles always offer a significant benefit. These applications have relatively large critical dimensions and require ultra thick photoresists with extremely high exposure doses. Given that the lithography is performed in Class 100 cleanroom conditions, it is possible that the risk of defects from contamination is sufficiently low that pellicles would not be required on certain process layer reticles. The elimination of the pellicle requirement would provide a cost reduction by saving the original pellicle cost and eliminating future pellicle replacement and repair costs. This study examines the imaging potential of defects with reticle patterns and processes typical for gold-bump and solder-bump advanced packaging lithography. The test reticle consists of 30 to 90 μm octagonal contact patterns representative of advanced packaging reticles. Programmed defects are added that represent the range of particle sizes (3 to 30 μm) normally protected by the pellicle and that are typical of advanced packaging lithography cleanrooms. The reticle is exposed using an Ultratech Saturn Spectrum 300e2 1X stepper on wafers coated with a variety of ultra thick (30 to 100 μm) positive and negative-acting photoresists commonly used in advanced packaging. The experimental results show that in many cases smaller particles continue to be yield issues for the feature size and density typical of advanced packaging processes. For the two negative photoresists studied it appears that a pellicle is not required for protection from defects smaller than 10 to 15 μm depending on the photoresist thickness. Thus the decision on pellicle usage for these materials would need to be made based on the device fabrication process and the cleanliness of a fabrication facility. For the two positive photoresists studied it appears that a pellicle is required to protect from defects down to 3 μm defects depending on the photoresist thickness. This suggests that a pellicle should always be used for these materials. Since a typical fabrication facility would use both positive and negative photoresists it may be advantageous to use pellicles on all reticles simply to avoid confusion. The cost savings of not using a pellicle could easily be outweighed by the yield benefits of using one.

40 CFR Table 32 to Subpart G of... - Typical Number of Roof Legs, a NF8

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Typical Number of Roof Legs, a NF8 32 Table 32 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Organic...

Characterization of extended channel bioreactors for continuous-flow protein production

DOE PAGES

Timm, Andrea C.; Shankles, Peter G.; Foster, Carmen M.; ...

2015-10-02

In this paper, protein based therapeutics are an important class of drugs, used to treat a variety of medical conditions including cancer and autoimmune diseases. Requiring continuous cold storage, and having a limited shelf life, the ability to produce such therapeutics at the point-of-care would open up new opportunities in distributing medicines and treating patients in more remote locations. Here, the authors describe the first steps in the development of a microfluidic platform that can be used for point-of-care protein synthesis. While biologic medicines, including therapeutic proteins, are commonly produced using recombinant deoxyribonucleic acid (DNA) technology in large batch cellmore » cultures, the system developed here utilizes cell-free protein synthesis (CFPS) technology. CFPS is a scalable technology that uses cell extracts containing the biological machinery required for transcription and translation and combines those extracts with DNA, encoding a specific gene, and the additional metabolites required to produce proteins in vitro. While CFPS reactions are typically performed in batch or fed-batch reactions, a well-engineered reaction scheme may improve both the rate of protein production and the economic efficiency of protein synthesis reactions, as well as enable a more streamlined method for subsequent purification of the protein product—all necessary requirements for point-of-care protein synthesis. In this work, the authors describe a new bioreactor design capable of continuous production of protein using cell-free protein synthesis. The bioreactors were designed with three inlets to separate reactive components prior to on-chip mixing, which lead into a long, narrow, serpentine channel. These multiscale, serpentine channel bioreactors were designed to take advantage of microscale diffusion distances across narrow channels in reactors containing enough volume to produce a therapeutic dose of protein, and open the possibility of performing these reactions continuously and in line with downstream purification modules. Here, the authors demonstrate the capability to produce protein over time with continuous-flow reactions and examine basic design features and operation specifications fundamental to continuous microfluidic protein synthesis.« less

An automated laboratory-scale methodology for the generation of sheared mammalian cell culture samples.

PubMed

Joseph, Adrian; Goldrick, Stephen; Mollet, Michael; Turner, Richard; Bender, Jean; Gruber, David; Farid, Suzanne S; Titchener-Hooker, Nigel

2017-05-01

Continuous disk-stack centrifugation is typically used for the removal of cells and cellular debris from mammalian cell culture broths at manufacturing-scale. The use of scale-down methods to characterise disk-stack centrifugation performance enables substantial reductions in material requirements and allows a much wider design space to be tested than is currently possible at pilot-scale. The process of scaling down centrifugation has historically been challenging due to the difficulties in mimicking the Energy Dissipation Rates (EDRs) in typical machines. This paper describes an alternative and easy-to-assemble automated capillary-based methodology to generate levels of EDRs consistent with those found in a continuous disk-stack centrifuge. Variations in EDR were achieved through changes in capillary internal diameter and the flow rate of operation through the capillary. The EDRs found to match the levels of shear in the feed zone of a pilot-scale centrifuge using the experimental method developed in this paper (2.4×10 5 W/Kg) are consistent with those obtained through previously published computational fluid dynamic (CFD) studies (2.0×10 5 W/Kg). Furthermore, this methodology can be incorporated into existing scale-down methods to model the process performance of continuous disk-stack centrifuges. This was demonstrated through the characterisation of culture hold time, culture temperature and EDRs on centrate quality. © 2017 The Authors. Biotechnology Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fully integrated biochip platforms for advanced healthcare.

PubMed

Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

2012-01-01

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Fully Integrated Biochip Platforms for Advanced Healthcare

PubMed Central

Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

2012-01-01

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications. PMID:23112644

Safety evaluation of continuous green T intersections.

DOT National Transportation Integrated Search

2016-04-01

The continuous green T (CGT) intersection is characterized by a channelized left-turn movement from the minor street approach onto the major street, along with a continuous through movement on the major street. The continuous through movement typical...

Convergence and Extrusion Are Required for Normal Fusion of the Mammalian Secondary Palate

PubMed Central

Kim, Seungil; Lewis, Ace E.; Singh, Vivek; Ma, Xuefei; Adelstein, Robert; Bush, Jeffrey O.

2015-01-01

The fusion of two distinct prominences into one continuous structure is common during development and typically requires integration of two epithelia and subsequent removal of that intervening epithelium. Using confocal live imaging, we directly observed the cellular processes underlying tissue fusion, using the secondary palatal shelves as a model. We find that convergence of a multi-layered epithelium into a single-layer epithelium is an essential early step, driven by cell intercalation, and is concurrent to orthogonal cell displacement and epithelial cell extrusion. Functional studies in mice indicate that this process requires an actomyosin contractility pathway involving Rho kinase (ROCK) and myosin light chain kinase (MLCK), culminating in the activation of non-muscle myosin IIA (NMIIA). Together, these data indicate that actomyosin contractility drives cell intercalation and cell extrusion during palate fusion and suggest a general mechanism for tissue fusion in development. PMID:25848986

Hyperglycemic crisis.

PubMed

Van Ness-Otunnu, Ronald; Hack, Jason B

2013-11-01

Hyperglycemic crisis is a metabolic emergency associated with uncontrolled diabetes mellitus that may result in significant morbidity or death. Acute interventions are required to manage hypovolemia, acidemia, hyperglycemia, electrolyte abnormalities, and precipitating causes. Despite advances in the prevention and management of diabetes, its prevalence and associated health care costs continue to increase worldwide. Hyperglycemic crisis typically requires critical care management and hospitalization and contributes to global health expenditures. Diagnostic and resolution criteria and management strategies for diabetic ketoacidosis and hyperosmolar hyperglycemic crisis are provided. A discussion of prevalence, mortality, pathophysiology, risk factors, clinical presentation, differential diagnosis, evaluation, and management considerations for hyperglycemic crisis are included. Emergency physicians confront the most severe sequelae of uncontrolled diabetes and provide crucial, life-saving management. With ongoing efforts from diabetes societies to incorporate the latest clinical research to refine treatment guidelines, management and outcomes of hyperglycemic crisis in the emergency department continue to improve. We provide an overview of the evaluation and treatment of hyperglycemic crisis and offer a concise, targeted management algorithm to aid the practicing emergency physician. Copyright © 2013 Elsevier Inc. All rights reserved.

Contemporary Clinical Management of Endometrial Cancer

PubMed Central

Dinkelspiel, Helen E.; Wright, Jason D.; Lewin, Sharyn N.; Herzog, Thomas J.

2013-01-01

Although the contemporary management of endometrial cancer is straightforward in many ways, novel data has emerged over the past decade that has altered the clinical standards of care while generating new controversies that will require further investigation. Fortunately most cases are diagnosed at early stages, but high-risk histologies and poorly differentiated tumors have high metastatic potential with a significantly worse prognosis. Initial management typically requires surgery, but the role and extent of lymphadenectomy are debated especially with well-differentiated tumors. With the changes in surgical staging, prognosis correlates more closely with stage, and the importance of cytology has been questioned and is under evaluation. The roles of radiation in intermediate-risk patients and chemotherapy in high-risk patients are emerging. The therapeutic index of brachytherapy needs to be considered, and the best sequencing of combined modalities needs to balance efficacy and toxicities. Additionally novel targeted therapies show promise, and further studies are needed to determine the appropriate use of these new agents. Management of endometrial cancer will continue to evolve as clinical trials continue to answer unsolved clinical questions. PMID:23864861

Fast mix table construction for material discretization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, S. R.

2013-07-01

An effective hybrid Monte Carlo-deterministic implementation typically requires the approximation of a continuous geometry description with a discretized piecewise-constant material field. The inherent geometry discretization error can be reduced somewhat by using material mixing, where multiple materials inside a discrete mesh voxel are homogenized. Material mixing requires the construction of a 'mix table,' which stores the volume fractions in every mixture so that multiple voxels with similar compositions can reference the same mixture. Mix table construction is a potentially expensive serial operation for large problems with many materials and voxels. We formulate an efficient algorithm to construct a sparse mixmore » table in O(number of voxels x log number of mixtures) time. The new algorithm is implemented in ADVANTG and used to discretize continuous geometries onto a structured Cartesian grid. When applied to an end-of-life MCNP model of the High Flux Isotope Reactor with 270 distinct materials, the new method improves the material mixing time by a factor of 100 compared to a naive mix table implementation. (authors)« less

Fast Mix Table Construction for Material Discretization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Seth R

2013-01-01

An effective hybrid Monte Carlo--deterministic implementation typically requires the approximation of a continuous geometry description with a discretized piecewise-constant material field. The inherent geometry discretization error can be reduced somewhat by using material mixing, where multiple materials inside a discrete mesh voxel are homogenized. Material mixing requires the construction of a ``mix table,'' which stores the volume fractions in every mixture so that multiple voxels with similar compositions can reference the same mixture. Mix table construction is a potentially expensive serial operation for large problems with many materials and voxels. We formulate an efficient algorithm to construct a sparse mix table inmore » $$O(\\text{number of voxels}\\times \\log \\text{number of mixtures})$$ time. The new algorithm is implemented in ADVANTG and used to discretize continuous geometries onto a structured Cartesian grid. When applied to an end-of-life MCNP model of the High Flux Isotope Reactor with 270 distinct materials, the new method improves the material mixing time by a factor of 100 compared to a naive mix table implementation.« less

49 CFR 178.356-5 - Typical assembly detail.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Typical assembly detail. 178.356-5 Section 178.356-5 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... Specifications for Packagings for Class 7 (Radioactive) Materials § 178.356-5 Typical assembly detail. (a...

49 CFR 178.358-6 - Typical assembly detail.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Typical assembly detail. 178.358-6 Section 178.358-6 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... Specifications for Packagings for Class 7 (Radioactive) Materials § 178.358-6 Typical assembly detail. (a...

49 CFR 178.356-5 - Typical assembly detail.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Typical assembly detail. 178.356-5 Section 178.356-5 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... Specifications for Packagings for Class 7 (Radioactive) Materials § 178.356-5 Typical assembly detail. (a...

49 CFR 178.356-5 - Typical assembly detail.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Typical assembly detail. 178.356-5 Section 178.356-5 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... Specifications for Packagings for Class 7 (Radioactive) Materials § 178.356-5 Typical assembly detail. (a...

49 CFR 178.358-6 - Typical assembly detail.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Typical assembly detail. 178.358-6 Section 178.358-6 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... Specifications for Packagings for Class 7 (Radioactive) Materials § 178.358-6 Typical assembly detail. (a...

49 CFR 178.358-6 - Typical assembly detail.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Typical assembly detail. 178.358-6 Section 178.358-6 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... Specifications for Packagings for Class 7 (Radioactive) Materials § 178.358-6 Typical assembly detail. (a...

Lifestyle modifications and the resolution of obstructive sleep apnea syndrome: a case report

PubMed Central

Gala, Thaddeus R.; Seaman, David R.

2011-01-01

Objective This purpose of this case study is to describe a natural method to help in management of obstructive sleep apnea syndrome (OSAS), which is known to be a common and debilitating condition. Clinical Features Obstructive sleep apnea syndrome is typically managed with a continuous positive airway pressure (CPAP) device, which the patient wears during sleep to help maintain respiration. This report describes the chiropractic management and resolution of OSAS with dietary modifications in a 55-year-old man who wore a CPAP for 10 years. Intervention and Outcome After adhering to dietary modifications for 3 months, the patient no longer required the use of the CPAP device and continues to have a normal active lifestyle almost 7 years later. Conclusion Dietary modifications may be an effective tool to improve the management of OSAS. PMID:22014867

Evaluating and Evolving Metadata in Multiple Dialects

NASA Technical Reports Server (NTRS)

Kozimore, John; Habermann, Ted; Gordon, Sean; Powers, Lindsay

2016-01-01

Despite many long-term homogenization efforts, communities continue to develop focused metadata standards along with related recommendations and (typically) XML representations (aka dialects) for sharing metadata content. Different representations easily become obstacles to sharing information because each representation generally requires a set of tools and skills that are designed, built, and maintained specifically for that representation. In contrast, community recommendations are generally described, at least initially, at a more conceptual level and are more easily shared. For example, most communities agree that dataset titles should be included in metadata records although they write the titles in different ways.

Coherent diffractive imaging of time-evolving samples with improved temporal resolution

DOE PAGES

Ulvestad, A.; Tripathi, A.; Hruszkewycz, S. O.; ...

2016-05-19

Bragg coherent x-ray diffractive imaging is a powerful technique for investigating dynamic nanoscale processes in nanoparticles immersed in reactive, realistic environments. Its temporal resolution is limited, however, by the oversampling requirements of three-dimensional phase retrieval. Here, we show that incorporating the entire measurement time series, which is typically a continuous physical process, into phase retrieval allows the oversampling requirement at each time step to be reduced, leading to a subsequent improvement in the temporal resolution by a factor of 2-20 times. The increased time resolution will allow imaging of faster dynamics and of radiation-dose-sensitive samples. Furthermore, this approach, which wemore » call "chrono CDI," may find use in improving the time resolution in other imaging techniques.« less

A sustainable genetic algorithm for satellite resource allocation

NASA Technical Reports Server (NTRS)

Abbott, R. J.; Campbell, M. L.; Krenz, W. C.

1995-01-01

A hybrid genetic algorithm is used to schedule tasks for 8 satellites, which can be modelled as a robot whose task is to retrieve objects from a two dimensional field. The objective is to find a schedule that maximizes the value of objects retrieved. Typical of the real-world tasks to which this corresponds is the scheduling of ground contacts for a communications satellite. An important feature of our application is that the amount of time available for running the scheduler is not necessarily known in advance. This requires that the scheduler produce reasonably good results after a short period but that it also continue to improve its results if allowed to run for a longer period. We satisfy this requirement by developing what we call a sustainable genetic algorithm.

African Primary Care Research: writing a research report.

PubMed

Couper, Ian; Mash, Bob

2014-06-06

Presenting a research report is an important way of demonstrating one's ability to conduct research and is a requirement of most research-based degrees. Although known by various names across academic institutions, the structure required is mostly very similar, being based on the Introduction, Methods, Results, Discussion format of scientific articles.This article offers some guidance on the process of writing, aimed at helping readers to start and to continue their writing; and to assist them in presenting a report that is received positively by their readers, including examiners. It also details the typical components of the research report, providing some guidelines for each, as well as the pitfalls to avoid.This article is part of a series on African Primary Care Research that aims to build capacity for research particularly at a Master's level.

Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics

PubMed Central

Battelino, Tadej; Danne, Thomas; Hovorka, Roman; Jarosz‐Chobot, Przemyslawa; Renard, Eric

2015-01-01

Summary The level of glycaemic control necessary to achieve optimal short‐term and long‐term outcomes in subjects with type 1 diabetes mellitus (T1DM) typically requires intensified insulin therapy using multiple daily injections or continuous subcutaneous insulin infusion. For continuous subcutaneous insulin infusion, the insulins of choice are the rapid‐acting insulin analogues, insulin aspart, insulin lispro and insulin glulisine. The advantages of continuous subcutaneous insulin infusion over multiple daily injections in adult and paediatric populations with T1DM include superior glycaemic control, lower insulin requirements and better health‐related quality of life/patient satisfaction. An association between continuous subcutaneous insulin infusion and reduced hypoglycaemic risk is more consistent in children/adolescents than in adults. The use of continuous subcutaneous insulin infusion is widely recommended in both adult and paediatric T1DM populations but is limited in pregnant patients and those with type 2 diabetes mellitus. All available rapid‐acting insulin analogues are approved for use in adult, paediatric and pregnant populations. However, minimum patient age varies (insulin lispro: no minimum; insulin aspart: ≥2 years; insulin glulisine: ≥6 years) and experience in pregnancy ranges from extensive (insulin aspart, insulin lispro) to limited (insulin glulisine). Although more expensive than multiple daily injections, continuous subcutaneous insulin infusion is cost‐effective in selected patient groups. This comprehensive review focuses on the European situation and summarises evidence for the efficacy and safety of continuous subcutaneous insulin infusion, particularly when used with rapid‐acting insulin analogues, in adult, paediatric and pregnant populations. The review also discusses relevant European guidelines; reviews issues that surround use of this technology; summarises the effects of continuous subcutaneous insulin infusion on patients' health‐related quality of life; reviews relevant pharmacoeconomic data; and discusses recent advances in pump technology, including the development of closed‐loop ‘artificial pancreas’ systems. © 2015 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons Ltd. PMID:25865292

Cisplatin-Induced Renal Salt Wasting Requiring over 12 Liters of 3% Saline Replacement

PubMed Central

Reddy, Pavani; Qaqish, Shaker; Kamath, Ashvin; Rodriguez, Johana; Bolos, David; Zalom, Martina; Pham, Phuong-Thu

2017-01-01

Cisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m2) and etoposide (100 mg/m2) therapy. Patient's serum sodium (SNa) decreased from 138 to 133 and 125 mEq/L within 24 and 48 hours of cisplatin therapy, respectively. A diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) was initially made. Despite free water restriction, patient's SNa continued to decrease in association with acute onset of headaches, nausea, and dizziness. Three percent saline (3%S) infusion with rates up to 1400 mL/day was required to correct and maintain SNa at 135 mEq/L. Studies to evaluate Fanconi syndrome revealed hypophosphatemia and glucosuria in the absence of serum hyperglycemia. The natriuresis slowed down by 2.5 weeks, but 3%S support was continued for a total volume of 12 liters over 3.5 weeks. Attempts of questionable benefits to slow down glomerular filtration included the administration of ibuprofen and benazepril. To our knowledge, this is the most severe case of RSW ever reported with cisplatin. PMID:28573057

40 CFR Table 30 to Subpart G of... - Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT 30 Table 30 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 30 to Subpart G of... - Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 10 2012-07-01 2012-07-01 false Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT 30 Table 30 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 30 to Subpart G of... - Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 10 2014-07-01 2014-07-01 false Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT 30 Table 30 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 30 to Subpart G of... - Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT 30 Table 30 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 30 to Subpart G of... - Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Roof Fitting Loss Factors, KFa, KFb, and m, a and Typical Number of Fittings, NT 30 Table 30 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

Supramolecular gel electrophoresis of large DNA fragments.

PubMed

Tazawa, Shohei; Kobayashi, Kazuhiro; Oyoshi, Takanori; Yamanaka, Masamichi

2017-10-01

Pulsed-field gel electrophoresis is a frequent technique used to separate exceptionally large DNA fragments. In a typical continuous field electrophoresis, it is challenging to separate DNA fragments larger than 20 kbp because they migrate at a comparable rate. To overcome this challenge, it is necessary to develop a novel matrix for the electrophoresis. Here, we describe the electrophoresis of large DNA fragments up to 166 kbp using a supramolecular gel matrix and a typical continuous field electrophoresis system. C 3 -symmetric tris-urea self-assembled into a supramolecular hydrogel in tris-boric acid-EDTA buffer, a typical buffer for DNA electrophoresis, and the supramolecular hydrogel was used as a matrix for electrophoresis to separate large DNA fragments. Three types of DNA marker, the λ-Hind III digest (2 to 23 kbp), Lambda DNA-Mono Cut Mix (10 to 49 kbp), and Marker 7 GT (10 to 165 kbp), were analyzed in this study. Large DNA fragments of greater than 100 kbp showed distinct mobility using a typical continuous field electrophoresis system. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Remote sensing requirements as suggested by watershed model sensitivity analyses

NASA Technical Reports Server (NTRS)

Salomonson, V. V.; Rango, A.; Ormsby, J. P.; Ambaruch, R.

1975-01-01

A continuous simulation watershed model has been used to perform sensitivity analyses that provide guidance in defining remote sensing requirements for the monitoring of watershed features and processes. The results show that out of 26 input parameters having meaningful effects on simulated runoff, 6 appear to be obtainable with existing remote sensing techniques. Of these six parameters, 3 require the measurement of the areal extent of surface features (impervious areas, water bodies, and the extent of forested area), two require the descrimination of land use that can be related to overland flow roughness coefficient or the density of vegetation so as to estimate the magnitude of precipitation interception, and one parameter requires the measurement of distance to get the length over which overland flow typically occurs. Observational goals are also suggested for monitoring such fundamental watershed processes as precipitation, soil moisture, and evapotranspiration. A case study on the Patuxent River in Maryland shows that runoff simulation is improved if recent satellite land use observations are used as model inputs as opposed to less timely topographic map information.

Saving Material with Systematic Process Designs

NASA Astrophysics Data System (ADS)

Kerausch, M.

2011-08-01

Global competition is forcing the stamping industry to further increase quality, to shorten time-to-market and to reduce total cost. Continuous balancing between these classical time-cost-quality targets throughout the product development cycle is required to ensure future economical success. In today's industrial practice, die layout standards are typically assumed to implicitly ensure the balancing of company specific time-cost-quality targets. Although die layout standards are a very successful approach, there are two methodical disadvantages. First, the capabilities for tool design have to be continuously adapted to technological innovations; e.g. to take advantage of the full forming capability of new materials. Secondly, the great variety of die design aspects have to be reduced to a generic rule or guideline; e.g. binder shape, draw-in conditions or the use of drawbeads. Therefore, it is important to not overlook cost or quality opportunities when applying die design standards. This paper describes a systematic workflow with focus on minimizing material consumption. The starting point of the investigation is a full process plan for a typical structural part. All requirements are definedaccording to a predefined set of die design standards with industrial relevance are fulfilled. In a first step binder and addendum geometry is systematically checked for material saving potentials. In a second step, blank shape and draw-in are adjusted to meet thinning, wrinkling and springback targets for a minimum blank solution. Finally the identified die layout is validated with respect to production robustness versus splits, wrinkles and springback. For all three steps the applied methodology is based on finite element simulation combined with a stochastical variation of input variables. With the proposed workflow a well-balanced (time-cost-quality) production process assuring minimal material consumption can be achieved.

Immobilized lysozyme for the continuous lysis of lactic bacteria in wine: Bench-scale fluidized-bed reactor study.

PubMed

Cappannella, Elena; Benucci, Ilaria; Lombardelli, Claudio; Liburdi, Katia; Bavaro, Teodora; Esti, Marco

2016-11-01

Lysozyme from hen egg white (HEWL) was covalently immobilized on spherical supports based on microbial chitosan in order to develop a system for the continuous, efficient and food-grade enzymatic lysis of lactic bacteria (Oenococcus oeni) in white and red wine. The objective is to limit the sulfur dioxide dosage required to control malolactic fermentation, via a cell concentration typical during this process. The immobilization procedure was optimized in batch mode, evaluating the enzyme loading, the specific activity, and the kinetic parameters in model wine. Subsequently, a bench-scale fluidized-bed reactor was developed, applying the optimized process conditions. HEWL appeared more effective in the immobilized form than in the free one, when the reactor was applied in real white and red wine. This preliminary study suggests that covalent immobilization renders the enzyme less sensitive to the inhibitory effect of wine flavans. Copyright © 2016 Elsevier Ltd. All rights reserved.

Actinomyces naeslundii and Eikenella corrodens as rare causes of liver abscesses.

PubMed

Jaqua, Nathan Thomas; Smith, Adam J; Shin, Terry T; Jahanmir, Jay

2013-07-17

A 48-year-old man with an unremarkable medical history was admitted with vague conditions of fever, chills, myalgias and malaise. Physical examination was remarkable for only scleral icterus. Laboratory evaluation revealed elevated aminotransferases, alkaline phosphatase and bilirubin. Imaging demonstrated two masses in the right lobe of his liver, which were ultimately drained and cultures demonstrated Actinomyces and Eikenella. He continued to have fever on broad-spectrum antibiotics until catheter drainage of the abscesses was performed. He was eventually discharged in improved condition on amoxicillin-clavulanate. His aminotransferases, alkaline phosphatase and bilirubin continued to improve and he remained afebrile and asymptomatic. A repeat CT 2 months after discharge demonstrated resolution of the abscesses. Actinomyces and Eikenella are rare causes of liver abscesses and treatment requires drainage and an extended course of antibiotics. The polymicrobial character typical of liver abscesses makes antibiotic therapy challenging when cultures reveal rare organisms such as Actinomyces and Eikenella.

Forgettable contraception.

PubMed

Grimes, David A

2009-12-01

The term "forgettable contraception" has received less attention in family planning than has "long-acting reversible contraception." Defined here as a method requiring attention no more often than every 3 years, forgettable contraception includes sterilization (female or male), intrauterine devices, and implants. Five principal factors determine contraceptive effectiveness: efficacy, compliance, continuation, fecundity, and the timing of coitus. Of these, compliance and continuation dominate; the key determinants of contraceptive effectiveness are human, not pharmacological. Human nature undermines methods with high theoretical efficacy, such as oral contraceptives and injectable contraceptives. By obviating the need to think about contraception for long intervals, forgettable contraception can help overcome our human fallibility. As a result, all forgettable contraception methods provide first-tier effectiveness (

Electrochemical detection for microscale analytical systems: a review.

PubMed

Wang, Joseph

2002-02-11

As the field of chip-based microscale systems continues its rapid growth, there are urgent needs for developing compatible detection modes. Electrochemistry detection offers considerable promise for such microfluidic systems, with features that include remarkable sensitivity, inherent miniaturization and portability, independence of optical path length or sample turbidity, low cost, low-power requirements and high compatibility with advanced micromachining and microfabrication technologies. This paper highlights recent advances, directions and key strategies in controlled-potential electrochemical detectors for miniaturized analytical systems. Subjects covered include the design and integration of the electrochemical detection system, its requirements and operational principles, common electrode materials, derivatization reactions, electrical-field decouplers, typical applications and future prospects. It is expected that electrochemical detection will become a powerful tool for microscale analytical systems and will facilitate the creation of truly portable (and possibly disposable) devices.

African Primary Care Research: Writing a research report

PubMed Central

Mash, Bob

2014-01-01

Abstract Presenting a research report is an important way of demonstrating one's ability to conduct research and is a requirement of most research-based degrees. Although known by various names across academic institutions, the structure required is mostly very similar, being based on the Introduction, Methods, Results, Discussion format of scientific articles. This article offers some guidance on the process of writing, aimed at helping readers to start and to continue their writing; and to assist them in presenting a report that is received positively by their readers, including examiners. It also details the typical components of the research report, providing some guidelines for each, as well as the pitfalls to avoid. This article is part of a series on African Primary Care Research that aims to build capacity for research particularly at a Master's level. PMID:26245441

UV protection for sunglasses: revisiting the standards

NASA Astrophysics Data System (ADS)

Masili, Mauro; Schiabel, Homero; Ventura, Liliane

2014-02-01

In a continuing work of establishing safe limits for UV protection on sunglasses, we have estimated the incident UV radiation for the 280 nm - 400 nm range for 5500 locations in Brazil. Current literature establishes safe limits regarding ultraviolet radiation exposure in the spectral region 180nm-400nm for weighted and unweighted UV radiant exposure. British Standard BSEN1836(2005) and American Standard ANZI Z80.3(2009) require the UV protection in the spectral range 280nm-380nm, and The Brazilian Standard for sunglasses protection, NBR15111(20013), currently requires protection for the 280nm - 400nm range as established by literature. However, none of them take into account the total (unweighted) UVA radiant exposure.Calculations of these limits have been made for 5500 Brazilian locations which included the geographic position of the city; altitude, inclination angle of the Earth; typical atmospheric data (ozone column; water vapor and others) as well as scattering from concrete, grass, sand, water, etc.. Furthermore, regarding UV safety for the ocular media, the resistance to irradiance test required on this standard of irradiating the lenses for 25 continuous hours with a 450W sunlight simulator leads to a correspondence of 26 hours and 10 minutes of continuous exposure to the Sun. Moreover, since the sun irradiance in Brazil is quite large, integrations made for the 280-400 nm range shows an average of 45% of greater ultraviolet radiant exposure than for the 280-380 nm range. Suggestions on the parameters of these tests are made in order to establish safe limits according to the UV irradiance in Brazil.

Near-Earth-Object identification over apparitions using n-body ranging

NASA Astrophysics Data System (ADS)

Granvik, Mikael; Muinonen, Karri

2007-05-01

Earth-based telescopes can observe Near-Earth objects (NEOs) continuously for a few weeks or months during each apparition. Due to the usually complicated dynamics of the Sun-Earth-NEO triplet, the time interval between consecutive apparitions typically ranges from months to several years. On these timescales single-apparition sets of observations (SASs) having reasonably small observational time-intervals lead to substantial orbital uncertainties. The linking of SASs over apparitions thus becomes a nontrivial task. Of a total of roughly 4,100 NEO observation sets, or orbits, currently known, some 500 are SASs for which the observational time interval is less than 7 days. Either these SASs have not been observed at an apparition following the discovery apparition (some 40% of the above NEO SASs have been obtained in 2005 or later), or the linkage of SASs has failed, an option which should preferably be eliminated. As a continuation to our work on the short-arc linking problem at the discovery moment (Granvik and Muinonen, 2005, Icarus 179, p. 109), we have investigated the possibility of using a similar method for the linking of SASs over apparitions. Assuming that the observational time-interval for SASs of NEOs is typically at least one day (minimum requirement set by the Minor Planet Center), the orbital-element probability density function is constrained as compared to the typical short-arc case with an observational time interval of only a few tens of minutes. Because of the smaller orbital-element uncertainty, we can use the short-arc method (comparison in ephemeris space) for longer time spans, or even do the comparison directly in orbital-element space (Keplerian, equinoctial, etc.), thus allowing us to assess the problem of linking SASs of NEOs. We will present linking results by using both simulated and real NEO SASs.

The Dependence of CNT Aerogel Synthesis on Sulfur-driven Catalyst Nucleation Processes and a Critical Catalyst Particle Mass Concentration.

PubMed

Hoecker, Christian; Smail, Fiona; Pick, Martin; Weller, Lee; Boies, Adam M

2017-11-06

The floating catalyst chemical vapor deposition (FC-CVD) process permits macro-scale assembly of nanoscale materials, enabling continuous production of carbon nanotube (CNT) aerogels. Despite the intensive research in the field, fundamental uncertainties remain regarding how catalyst particle dynamics within the system influence the CNT aerogel formation, thus limiting effective scale-up. While aerogel formation in FC-CVD reactors requires a catalyst (typically iron, Fe) and a promotor (typically sulfur, S), their synergistic roles are not fully understood. This paper presents a paradigm shift in the understanding of the role of S in the process with new experimental studies identifying that S lowers the nucleation barrier of the catalyst nanoparticles. Furthermore, CNT aerogel formation requires a critical threshold of Fe x C y  > 160 mg/m 3 , but is surprisingly independent of the initial catalyst diameter or number concentration. The robustness of the critical catalyst mass concentration principle is proved further by producing CNTs using alternative catalyst systems; Fe nanoparticles from a plasma spark generator and cobaltocene and nickelocene precursors. This finding provides evidence that low-cost and high throughput CNT aerogel routes may be achieved by decoupled and enhanced catalyst production and control, opening up new possibilities for large-scale CNT synthesis.

Architecture Study on Telemetry Coverage for Immediate Post-Separation Phase

NASA Technical Reports Server (NTRS)

Cheung, Kar-Ming; Lee, Charles; Kellogg, Kent; Stocklin, Frank; Zillig, David; Fielhauer, Karl

2008-01-01

This document is the viewgraphs that accompanies a paper that presents the preliminary results of an architecture study that provides continuous telemetry coverage for NASA missions for immediate post-separation phase. After launch when the spacecraft separated from the upper stage, the spacecraft typically executes a number of mission-critical operations prior to the deployment of solar panels and the activation of the primary communication subsystem. JPL, GSFC, and APL have similar design principle statements that require continuous coverage of mission-critical telemetry during the immediate post-separation phase. To conform to these design principles, an architecture that consists of a separate spacecraft transmitter and a robust communication network capable of tracking the spacecraft signals is needed. The main results of this study are as follows: 1) At low altitude (< 10000 km) when most post-separation critical operations are executed, Earth-based network (e.g. Deep Space Network (DSN)) can only provide limited coverage, whereas space-based network (e.g. Space Network (SN)) can provide continuous coverage. 2) Commercial-off-the-shelf SN compatible transmitters are available for small satellite applications. In this paper we present the detailed coverage analysis of Earth-based and Space-based networks. We identify the key functional and performance requirements of the architecture, and describe the proposed selection criteria of the spacecraft transmitter. We conclude the paper with a proposed forward plan.

Mastering multi-depth bio-chip patterns with DVD LBRs

NASA Astrophysics Data System (ADS)

Carson, Doug

2017-08-01

Bio chip and bio disc are rapidly growing technologies used in medical, health and other industries. While there are numerous unique designs and features, these products all rely on precise three-dimensional micro-fluidic channels or arrays to move, separate and combine samples under test. These bio chip and bio disc consumables are typically manufactured by molding these parts to a precise three-dimensional pattern on a negative metal stamper, or they can be made in smaller quantities using an appropriate curable resin and a negative mold/stamper. Stampers required for bio chips have been traditionally made using either micro machining or XY stepping lithography. Both of these technologies have their advantages as well as limitations when it comes to creating micro-fluidic patterns. Significant breakthroughs in continuous maskless lithography have enabled accurate and efficient manufacturing of micro-fluidic masters using LBRs (Laser Beam Recorders) and DRIE (Deep Reactive Ion Etching). The important advantages of LBR continuous lithography vs. XY stepping lithography and micro machining are speed and cost. LBR based continuous lithography is >100x faster than XY stepping lithography and more accurate than micro machining. Several innovations were required in order to create multi-depth patterns with sub micron accuracy. By combining proven industrial LBRs with DCA's G3-VIA pattern generator and DRIE, three-dimensional bio chip masters and stampers are being manufactured efficiently and accurately.

A micro-reactor for preparing uniform molecularly imprinted polymer beads.

PubMed

Zourob, Mohammed; Mohr, Stephan; Mayes, Andrew G; Macaskill, Alexandra; Pérez-Moral, Natalia; Fielden, Peter R; Goddard, Nicholas J

2006-02-01

In this study, uniform spherical molecularly imprinted polymer beads were prepared via controlled suspension polymerization in a spiral-shaped microchannel using mineral oil and perfluorocarbon liquid as continuous phases. Monodisperse droplets containing the monomers, template, initiator, and porogenic solvent were introduced into the microchannel, and particles of uniform size were produced by subsequent UV polymerization, quickly and without wasting polymer materials. The droplet/particle size was varied by changing the flow conditions in the microfluidic device. The diameter of the resulting products typically had a coefficient of variation (CV) below 2%. The specific binding sites that were created during the imprinting process were analysed via radioligand binding analysis. The molecularly imprinted microspheres produced in the liquid perfluorocarbon continuous phase had a higher binding capacity compared with the particles produced in the mineral oil continuous phase, though it should be noted that the aim of this study was not to optimize or maximize imprinting performance, but rather to demonstrate broad applicability and compatibility with known MIP production methods. The successful imprinting against a model compound using two very different continuous phases (one requiring a surfactant to stabilize the droplets the other not) demonstrates the generality of this current simple approach.

Considerations of technology transfer barriers in the modification of strategic superalloys for aircraft turbine engines

NASA Technical Reports Server (NTRS)

Stephens, J. R.; Tien, J. K.

1983-01-01

A typical innovation-to-commercialization process for the development of a new hot section gas turbine material requires one to two decades with attendant costs in the tens of millions of dollars. This transfer process is examined to determine the potential rate-controlling steps for introduction of future low strategic metal content alloys or processes. Case studies are used to highlight the barriers to commercialization as well as to identify the means by which these barriers can be surmounted. The opportunities for continuing joint government-university-industry partnerships in planning and conducting strategic materials R&D programs are also discussed.

Diabetic retinopathy: retina-specific methods for maintenance of diabetic rodents and evaluation of vascular histopathology and molecular abnormalities

PubMed Central

Veenstra, Alexander; Liu, Haitao; Lee, Chieh Allen; Du, Yunpeng; Tang, Jie; Kern, Timothy S.

2015-01-01

Diabetic retinopathy is a major cause of visual impairment, which continues to increase in prevalence as more and more people develop diabetes. Despite the importance of vision, the retina is one of the smallest tissues in the body, and specialized techniques to study the retinopathy have been developed. This chapter will summarize several methods used to (i) induce diabetes, (ii) maintain the diabetic animals throughout the months required for the development of typical vascular histopathology, (iii) evaluate vascular histopathology of diabetic retinopathy, and (iv) quantitate abnormalities implicated in the development of the retinopathy. PMID:26331759

GEH-4-42, 47; Hot pressed, I and E cooled fuel element irradiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neidner, R.

1959-11-02

In our continual effort to improve the present fuel elements which are irradiated in the numerous Hanford reactors, we have made what we believe to be a significant improvement in the hot pressing process for jacketing uranium fuel slugs. We are proposing a large scale evaluation testing program in the Hanford reactors but need the vital and basic information on the operating characteristics of this type slug under known and controlled operating conditions. We, therefore, have prepared two typical fuel slugs and will want them irradiated to about 1000 MWD/T exposure (this will require about four to five total cycles).

Protein Folding Using a Vortex Fluidic Device.

PubMed

Britton, Joshua; Smith, Joshua N; Raston, Colin L; Weiss, Gregory A

2017-01-01

Essentially all biochemistry and most molecular biology experiments require recombinant proteins. However, large, hydrophobic proteins typically aggregate into insoluble and misfolded species, and are directed into inclusion bodies. Current techniques to fold proteins recovered from inclusion bodies rely on denaturation followed by dialysis or rapid dilution. Such approaches can be time consuming, wasteful, and inefficient. Here, we describe rapid protein folding using a vortex fluidic device (VFD). This process uses mechanical energy introduced into thin films to rapidly and efficiently fold proteins. With the VFD in continuous flow mode, large volumes of protein solution can be processed per day with 100-fold reductions in both folding times and buffer volumes.

Automatic Differentiation as a tool in engineering design

NASA Technical Reports Server (NTRS)

Barthelemy, Jean-Francois M.; Hall, Laura E.

1992-01-01

Automatic Differentiation (AD) is a tool that systematically implements the chain rule of differentiation to obtain the derivatives of functions calculated by computer programs. In this paper, it is assessed as a tool for engineering design. The paper discusses the forward and reverse modes of AD, their computing requirements, and approaches to implementing AD. It continues with application to two different tools to two medium-size structural analysis problems to generate sensitivity information typically necessary in an optimization or design situation. The paper concludes with the observation that AD is to be preferred to finite differencing in most cases, as long as sufficient computer storage is available.

Parallel plate radiofrequency ion thruster

NASA Technical Reports Server (NTRS)

Nakanishi, S.

1982-01-01

An 8-cm-diam. argon ion thruster is described. It is operated by applying 100 to 160 Mhz rf power across a thin plasma volume in a strongly divergent static magnetic field. No cathode or electron emitter is required to sustain a continuous wave plasma discharge over a broad range of propellant gas flow. Preliminary results indicate that a large fraction of the incident power is being reflected by impedance mismatching in the coupling structure. Resonance effects due to plasma thickness, magnetic field strength, and distribution are presented. Typical discharge losses obtained to date are 500 to 600 W per beam ampere at extracted beam currents up to 60 mA.

Innovative microwave design leads to smart, small EW systems

NASA Astrophysics Data System (ADS)

Niehenke, Edward C.

1988-02-01

An account is given of the state-of-the-art in microwave component and system design for EW systems, whose size and weight has been progressively reduced in recent years as a result of continuing design innovation in microwave circuitry. Typically, AI-function computers are employed to control microwave functions in a way that allows rapid RAM or ROM software modification to meet new performance requirements, thereby obviating hardware modifications. Attention is given to high-isolation GaAs MMIC filters, switches and amplifiers, frequency converters, instantaneous frequency measurement systems, frequency translators, digital RF memories, and high effective radiated power solid-state active antenna arrays.

Signal Conditioning for Satellite Borne Energetic-Charged-Particle Experiments

NASA Technical Reports Server (NTRS)

Ludwig, George H.

1961-01-01

Many of the spacecraft launched thus far have carried detectors for investigating cosmic rays, solar protons, solar plasmas, and the geomagnetically trapped radiation. These detectors, which will find continued application in the future, include ion chambers; proportional, Geiger-Muller, scintillation, Cerenkov, and solid state detectors; ion collectors; and nuclear emulsions. The instrumentation required to condition the signals from these detectors prior to telemetering is steadily growing more complex in order to permit more meaningful measurements. This report describes a number of instrumentation elements typical of the present state of the art, and a present-generation three-detector system which illustrates the integration of such basic elements into a complex system.

Methods to estimate the between‐study variance and its uncertainty in meta‐analysis†

PubMed Central

Jackson, Dan; Viechtbauer, Wolfgang; Bender, Ralf; Bowden, Jack; Knapp, Guido; Kuss, Oliver; Higgins, Julian PT; Langan, Dean; Salanti, Georgia

2015-01-01

Meta‐analyses are typically used to estimate the overall/mean of an outcome of interest. However, inference about between‐study variability, which is typically modelled using a between‐study variance parameter, is usually an additional aim. The DerSimonian and Laird method, currently widely used by default to estimate the between‐study variance, has been long challenged. Our aim is to identify known methods for estimation of the between‐study variance and its corresponding uncertainty, and to summarise the simulation and empirical evidence that compares them. We identified 16 estimators for the between‐study variance, seven methods to calculate confidence intervals, and several comparative studies. Simulation studies suggest that for both dichotomous and continuous data the estimator proposed by Paule and Mandel and for continuous data the restricted maximum likelihood estimator are better alternatives to estimate the between‐study variance. Based on the scenarios and results presented in the published studies, we recommend the Q‐profile method and the alternative approach based on a ‘generalised Cochran between‐study variance statistic’ to compute corresponding confidence intervals around the resulting estimates. Our recommendations are based on a qualitative evaluation of the existing literature and expert consensus. Evidence‐based recommendations require an extensive simulation study where all methods would be compared under the same scenarios. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons Ltd. PMID:26332144

Image barcodes

NASA Astrophysics Data System (ADS)

Damera-Venkata, Niranjan; Yen, Jonathan

2003-01-01

A Visually significant two-dimensional barcode (VSB) developed by Shaked et. al. is a method used to design an information carrying two-dimensional barcode, which has the appearance of a given graphical entity such as a company logo. The encoding and decoding of information using the VSB, uses a base image with very few graylevels (typically only two). This typically requires the image histogram to be bi-modal. For continuous-tone images such as digital photographs of individuals, the representation of tone or "shades of gray" is not only important to obtain a pleasing rendition of the face, but in most cases, the VSB renders these images unrecognizable due to its inability to represent true gray-tone variations. This paper extends the concept of a VSB to an image bar code (IBC). We enable the encoding and subsequent decoding of information embedded in the hardcopy version of continuous-tone base-images such as those acquired with a digital camera. The encoding-decoding process is modeled by robust data transmission through a noisy print-scan channel that is explicitly modeled. The IBC supports a high information capacity that differentiates it from common hardcopy watermarks. The reason for the improved image quality over the VSB is a joint encoding/halftoning strategy based on a modified version of block error diffusion. Encoder stability, image quality vs. information capacity tradeoffs and decoding issues with and without explicit knowledge of the base-image are discussed.

Theoretical and Empirical Comparisons between Two Models for Continuous Item Responses.

ERIC Educational Resources Information Center

Ferrando, Pere J.

2002-01-01

Analyzed the relations between two continuous response models intended for typical response items: the linear congeneric model and Samejima's continuous response model (CRM). Illustrated the relations described using an empirical example and assessed the relations through a simulation study. (SLD)

Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics.

PubMed

Pozzilli, Paolo; Battelino, Tadej; Danne, Thomas; Hovorka, Roman; Jarosz-Chobot, Przemyslawa; Renard, Eric

2016-01-01

The level of glycaemic control necessary to achieve optimal short-term and long-term outcomes in subjects with type 1 diabetes mellitus (T1DM) typically requires intensified insulin therapy using multiple daily injections or continuous subcutaneous insulin infusion. For continuous subcutaneous insulin infusion, the insulins of choice are the rapid-acting insulin analogues, insulin aspart, insulin lispro and insulin glulisine. The advantages of continuous subcutaneous insulin infusion over multiple daily injections in adult and paediatric populations with T1DM include superior glycaemic control, lower insulin requirements and better health-related quality of life/patient satisfaction. An association between continuous subcutaneous insulin infusion and reduced hypoglycaemic risk is more consistent in children/adolescents than in adults. The use of continuous subcutaneous insulin infusion is widely recommended in both adult and paediatric T1DM populations but is limited in pregnant patients and those with type 2 diabetes mellitus. All available rapid-acting insulin analogues are approved for use in adult, paediatric and pregnant populations. However, minimum patient age varies (insulin lispro: no minimum; insulin aspart: ≥2 years; insulin glulisine: ≥6 years) and experience in pregnancy ranges from extensive (insulin aspart, insulin lispro) to limited (insulin glulisine). Although more expensive than multiple daily injections, continuous subcutaneous insulin infusion is cost-effective in selected patient groups. This comprehensive review focuses on the European situation and summarises evidence for the efficacy and safety of continuous subcutaneous insulin infusion, particularly when used with rapid-acting insulin analogues, in adult, paediatric and pregnant populations. The review also discusses relevant European guidelines; reviews issues that surround use of this technology; summarises the effects of continuous subcutaneous insulin infusion on patients' health-related quality of life; reviews relevant pharmacoeconomic data; and discusses recent advances in pump technology, including the development of closed-loop 'artificial pancreas' systems. © 2015 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons Ltd. © 2015 The Authors. Diabetes/Metabolism Research and Reviews Published by John Wiley & Sons Ltd.

Dynamic Radioactive Source for Evaluating and Demonstrating Time-dependent Performance of Continuous Air Monitors.

PubMed

McLean, Thomas D; Moore, Murray E; Justus, Alan L; Hudston, Jonathan A; Barbé, Benoît

2016-11-01

Evaluation of continuous air monitors in the presence of a plutonium aerosol is time intensive, expensive, and requires a specialized facility. The Radiation Protection Services Group at Los Alamos National Laboratory has designed a Dynamic Radioactive Source, intended to replace plutonium aerosol challenge testing. The Dynamic Radioactive Source is small enough to be inserted into the sampler filter chamber of a typical continuous air monitor. Time-dependent radioactivity is introduced from electroplated sources for real-time testing of a continuous air monitor where a mechanical wristwatch motor rotates a mask above an alpha-emitting electroplated disk source. The mask is attached to the watch's minute hand, and as it rotates, more of the underlying source is revealed. The measured alpha activity increases with time, simulating the arrival of airborne radioactive particulates at the air sampler inlet. The Dynamic Radioactive Source allows the temporal behavior of puff and chronic release conditions to be mimicked without the need for radioactive aerosols. The new system is configurable to different continuous air monitor designs and provides an in-house testing capability (benchtop compatible). It is a repeatable and reusable system and does not contaminate the tested air monitor. Test benefits include direct user control, realistic (plutonium) aerosol spectra, and iterative development of continuous air monitor alarm algorithms. Data obtained using the Dynamic Radioactive Source has been used to elucidate alarm algorithms and to compare the response time of two commercial continuous air monitors.

Dynamic Radioactive Source for Evaluating and Demonstrating Time-dependent Performance of Continuous Air Monitors

DOE PAGES

McLean, Thomas D.; Moore, Murray E.; Justus, Alan L.; ...

2016-01-01

Evaluation of continuous air monitors in the presence of a plutonium aerosol is time intensive, expensive, and requires a specialized facility. The Radiation Protection Services Group at Los Alamos National Laboratory has designed a Dynamic Radioactive Source, intended to replace plutonium aerosol challenge testing. Furthermore, the Dynamic Radioactive Source is small enough to be inserted into the sampler filter chamber of a typical continuous air monitor. Time-dependent radioactivity is introduced from electroplated sources for real-time testing of a continuous air monitor where a mechanical wristwatch motor rotates a mask above an alpha-emitting electroplated disk source. The mask is attached tomore » the watch’s minute hand, and as it rotates, more of the underlying source is revealed. The alpha activity we measured increases with time, simulating the arrival of airborne radioactive particulates at the air sampler inlet. The Dynamic Radioactive Source allows the temporal behavior of puff and chronic release conditions to be mimicked without the need for radioactive aerosols. The new system is configurable to different continuous air monitor designs and provides an in-house testing capability (benchtop compatible). It is a repeatable and reusable system and does not contaminate the tested air monitor. Test benefits include direct user control, realistic (plutonium) aerosol spectra, and iterative development of continuous air monitor alarm algorithms. We also used data obtained using the Dynamic Radioactive Source to elucidate alarm algorithms and to compare the response time of two commercial continuous air monitors.« less

Will a category cue attract you? Motor output reveals dynamic competition across person construal.

PubMed

Freeman, Jonathan B; Ambady, Nalini; Rule, Nicholas O; Johnson, Kerri L

2008-11-01

People use social categories to perceive others, extracting category cues to glean membership. Growing evidence for continuous dynamics in real-time cognition suggests, contrary to prevailing social psychological accounts, that person construal may involve dynamic competition between simultaneously active representations. To test this, the authors examined social categorization in real-time by streaming the x, y coordinates of hand movements as participants categorized typical and atypical faces by sex. Though judgments of atypical targets were largely accurate, online motor output exhibited a continuous spatial attraction toward the opposite sex category, indicating dynamic competition between multiple social category alternatives. The authors offer a dynamic continuity account of social categorization and provide converging evidence across categorizations of real male and female faces (containing a typical or an atypical sex-specifying cue) and categorizations of computer-generated male and female faces (with subtly morphed sex-typical or sex-atypical features). In 3 studies, online motor output revealed continuous dynamics underlying person construal, in which multiple simultaneously and partially active category representations gradually cascade into social categorical judgments. Such evidence is challenging for discrete stage-based accounts. (c) 2008 APA, all rights reserved

Considerations in development of expert systems for real-time space applications

NASA Technical Reports Server (NTRS)

Murugesan, S.

1988-01-01

Over the years, demand on space systems has increased tremendously and this trend will continue for the near future. Enhanced capabilities of space systems, however, can only be met with increased complexity and sophistication of onboard and ground systems. Artificial Intelligence and expert system techniques have great potential in space applications. Expert systems could facilitate autonomous decision making, improve in-orbit fault diagnosis and repair, enhance performance and reduce reliance on ground support. However, real-time expert systems, unlike conventional off-line consultative systems, have to satisfy certain special stringent requirements before they could be used for onboard space applications. Challenging and interesting new environments are faced while developing expert system space applications. This paper discusses the special characteristics, requirements and typical life cycle issues for onboard expert systems. Further, it also describes considerations in design, development, and implementation which are particularly important to real-time expert systems for space applications.

Optimization of Operations Resources via Discrete Event Simulation Modeling

NASA Technical Reports Server (NTRS)

Joshi, B.; Morris, D.; White, N.; Unal, R.

1996-01-01

The resource levels required for operation and support of reusable launch vehicles are typically defined through discrete event simulation modeling. Minimizing these resources constitutes an optimization problem involving discrete variables and simulation. Conventional approaches to solve such optimization problems involving integer valued decision variables are the pattern search and statistical methods. However, in a simulation environment that is characterized by search spaces of unknown topology and stochastic measures, these optimization approaches often prove inadequate. In this paper, we have explored the applicability of genetic algorithms to the simulation domain. Genetic algorithms provide a robust search strategy that does not require continuity and differentiability of the problem domain. The genetic algorithm successfully minimized the operation and support activities for a space vehicle, through a discrete event simulation model. The practical issues associated with simulation optimization, such as stochastic variables and constraints, were also taken into consideration.

A review of iron and cobalt porphyrins, phthalocyanines, and related complexes for electrochemical and photochemical reduction of carbon dioxide

DOE PAGES

Manbeck, Gerald F.; Fujita, Etsuko

2015-03-30

This review summarizes research on the electrochemical and photochemical reduction of CO₂ using a variety of iron and cobalt porphyrins, phthalocyanines, and related complexes. Metalloporphyrins and metallophthalocyanines are visible light absorbers with extremely large extinction coefficients. However, yields of photochemically-generated active catalysts for CO₂ reduction are typically low owing to the requirement of a second photoinduced electron. This requirement is not relevant to the case of electrochemical CO₂ reduction. Recent progress on efficient and stable electrochemical systems includes the use of FeTPP catalysts that have prepositioned phenyl OH groups in their second coordination spheres. This has led to remarkable progressmore » in carrying out coupled proton-electron transfer reactions for CO₂ reduction. Such ground-breaking research has to be continued in order to produce renewable fuels in an economically feasible manner.« less

Development of New Sensing Materials Using Combinatorial and High-Throughput Experimentation

NASA Astrophysics Data System (ADS)

Potyrailo, Radislav A.; Mirsky, Vladimir M.

New sensors with improved performance characteristics are needed for applications as diverse as bedside continuous monitoring, tracking of environmental pollutants, monitoring of food and water quality, monitoring of chemical processes, and safety in industrial, consumer, and automotive settings. Typical requirements in sensor improvement are selectivity, long-term stability, sensitivity, response time, reversibility, and reproducibility. Design of new sensing materials is the important cornerstone in the effort to develop new sensors. Often, sensing materials are too complex to predict their performance quantitatively in the design stage. Thus, combinatorial and high-throughput experimentation methodologies provide an opportunity to generate new required data to discover new sensing materials and/or to optimize existing material compositions. The goal of this chapter is to provide an overview of the key concepts of experimental development of sensing materials using combinatorial and high-throughput experimentation tools, and to promote additional fruitful interactions between computational scientists and experimentalists.

Studies in Software Cost Model Behavior: Do We Really Understand Cost Model Performance?

NASA Technical Reports Server (NTRS)

Lum, Karen; Hihn, Jairus; Menzies, Tim

2006-01-01

While there exists extensive literature on software cost estimation techniques, industry practice continues to rely upon standard regression-based algorithms. These software effort models are typically calibrated or tuned to local conditions using local data. This paper cautions that current approaches to model calibration often produce sub-optimal models because of the large variance problem inherent in cost data and by including far more effort multipliers than the data supports. Building optimal models requires that a wider range of models be considered while correctly calibrating these models requires rejection rules that prune variables and records and use multiple criteria for evaluating model performance. The main contribution of this paper is to document a standard method that integrates formal model identification, estimation, and validation. It also documents what we call the large variance problem that is a leading cause of cost model brittleness or instability.

Dose Control System in the Optima XE Single Wafer High Energy Ion Implanter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Satoh, Shu; Yoon, Jongyoon; David, Jonathan

2011-01-07

Photoresist outgassing can significantly compromise accurate dosimetry of high energy implants. High energy implant even at a modest beam current produces high beam powers which create significantly worse outgassing than low and medium energy implants and the outgassing continues throughout the implant due to the low dose in typical high energy implant recipes. In the previous generation of high energy implanters, dose correction by monitoring of process chamber pressure during photoresist outgassing has been used. However, as applications diversify and requirements change, the need arises for a more versatile photoresist correction system to match the versatility of a single wafermore » high energy ion implanter. We have successfully developed a new dosimetry system for the Optima XE single wafer high energy ion implanter which does not require any form of compensation due to the implant conditions. This paper describes the principles and performance of this new dose system.« less

Body worn camera

NASA Astrophysics Data System (ADS)

Aishwariya, A.; Pallavi Sudhir, Gulavani; Garg, Nemesa; Karthikeyan, B.

2017-11-01

A body worn camera is small video camera worn on the body, typically used by police officers to record arrests, evidence from crime scenes. It helps preventing and resolving complaints brought by members of the public; and strengthening police transparency, performance, and accountability. The main constants of this type of the system are video format, resolution, frames rate, and audio quality. This system records the video in .mp4 format with 1080p resolution and 30 frames per second. One more important aspect to while designing this system is amount of power the system requires as battery management becomes very critical. The main design challenges are Size of the Video, Audio for the video. Combining both audio and video and saving it in .mp4 format, Battery, size that is required for 8 hours of continuous recording, Security. For prototyping this system is implemented using Raspberry Pi model B.

Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production.

PubMed

Steinebach, Fabian; Müller-Späth, Thomas; Morbidelli, Massimo

2016-09-01

The economic advantages of continuous processing of biopharmaceuticals, which include smaller equipment and faster, efficient processes, have increased interest in this technology over the past decade. Continuous processes can also improve quality assurance and enable greater controllability, consistent with the quality initiatives of the FDA. Here, we discuss different continuous multi-column chromatography processes. Differences in the capture and polishing steps result in two different types of continuous processes that employ counter-current column movement. Continuous-capture processes are associated with increased productivity per cycle and decreased buffer consumption, whereas the typical purity-yield trade-off of classical batch chromatography can be surmounted by continuous processes for polishing applications. In the context of continuous manufacturing, different but complementary chromatographic columns or devices are typically combined to improve overall process performance and avoid unnecessary product storage. In the following, these various processes, their performances compared with batch processing and resulting product quality are discussed based on a review of the literature. Based on various examples of applications, primarily monoclonal antibody production processes, conclusions are drawn about the future of these continuous-manufacturing technologies. Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

When Disaster Strikes

ERIC Educational Resources Information Center

Henderson, Douglas M.

2005-01-01

In a typical Continuity of Operation Plan (COOP) for a school or university, the primary objectives are the maintenance of life support and environmental health services. Often, schools and universities focus on responding to emergency events and place less emphasis on continuity planning. As a result, continuity-planning issues sometimes are not…

Rights of Conscience Protections for Armed Forces Service Members and Their Chaplains

DTIC Science & Technology

2015-07-22

established five categories of religious accommodation requests: dietary, grooming, medical , uniform, and worship practices.2 • Dietary: typically, these... Medical : typically, these are requests for a waiver of mandatory immunizations. • Uniform: typically, these are requests to wear religious jewelry or...service members in their units. Requirements A chaplain applicant is required to meet DoD medical and physical standards for commissioning as an

Domestic Cats (Felis silvestris catus) Do Not Show Signs of Secure Attachment to Their Owners

PubMed Central

Potter, Alice; Mills, Daniel Simon

2015-01-01

The Ainsworth Strange Situation Test (SST) has been widely used to demonstrate that the bond between both children and dogs to their primary carer typically meets the requirements of a secure attachment (i.e. the carer being perceived as a focus of safety and security in otherwise threatening environments), and has been adapted for cats with a similar claim made. However methodological problems in this latter research make the claim that the cat-owner bond is typically a secure attachment, operationally definable by its behaviour in the SST, questionable. We therefore developed an adapted version of the SST with the necessary methodological controls which include a full counterbalance of the procedure. A cross-over design experiment with 20 cat-owner pairs (10 each undertaking one of the two versions of the SST first) and continuous focal sampling was used to record the duration of a range of behavioural states expressed by the cats that might be useful for assessing secure attachment. Since data were not normally distributed, non-parametric analyses were used on those behaviours shown to be reliable across the two versions of the test (which excluded much cat behaviour). Although cats vocalised more when the owner rather the stranger left the cat with the other individual, there was no other evidence consistent with the interpretation of the bond between a cat and its owner meeting the requirements of a secure attachment. These results are consistent with the view that adult cats are typically quite autonomous, even in their social relationships, and not necessarily dependent on others to provide a sense of security and safety. It is concluded that alternative methods need to be developed to characterise the normal psychological features of the cat-owner bond. PMID:26332470

Kangaroo mother care to reduce morbidity and mortality in low birthweight infants.

PubMed

Conde-Agudelo, Agustin; Belizán, José M; Diaz-Rossello, Jose

2011-03-16

Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants. To determine whether there is evidence to support the use of KMC in LBW infants as an alternative to conventional neonatal care. The standard search strategy of the Cochrane Neonatal Group was used. This included searches of MEDLINE, EMBASE, LILACS, POPLINE, CINAHL databases (from inception to January 31, 2011), and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2011). In addition, we searched the web page of the Kangaroo Foundation, conference and symposia proceedings on KMC, and Google scholar. Randomized controlled trials comparing KMC versus conventional neonatal care, or early onset KMC (starting within 24 hours after birth) versus late onset KMC (starting after 24 hours after birth) in LBW infants. Data collection and analysis were performed according to the methods of the Cochrane Neonatal Review Group. Sixteen studies, including 2518 infants, fulfilled inclusion criteria. Fourteen studies evaluated KMC in LBW infants after stabilization, one evaluated KMC in LBW infants before stabilization, and one compared early onset KMC with late onset KMC in relatively stable LBW infants. Eleven studies evaluated intermittent KMC and five evaluated continuous KMC. At discharge or 40 - 41 weeks' postmenstrual age, KMC was associated with a reduction in the risk of mortality (typical risk ratio (RR) 0.60, 95% confidence interval (CI) 0.39 to 0.93; seven trials, 1614 infants), nosocomial infection/sepsis (typical RR 0.42, 95% CI 0.24 to 0.73), hypothermia (typical RR 0.23, 95% CI 0.10 to 0.55), and length of hospital stay (typical mean difference 2.4 days, 95% CI 0.7 to 4.1). At latest follow up, KMC was associated with a decreased risk of mortality (typical RR 0.68, 95% CI 0.48 to 0.96; nine trials, 1952 infants) and severe infection/sepsis (typical RR 0.57, 95% CI 0.40 to 0.80). Moreover, KMC was found to increase some measures of infant growth, breastfeeding, and mother-infant attachment. The evidence from this updated review supports the use of KMC in LBW infants as an alternative to conventional neonatal care mainly in resource-limited settings. Further information is required concerning effectiveness and safety of early onset continuous KMC in unstabilized LBW infants, long term neurodevelopmental outcomes, and costs of care.

Cross-beam coherence of infrasonic signals at local and regional ranges.

PubMed

Alberts, W C Kirkpatrick; Tenney, Stephen M

2017-11-01

Signals collected by infrasound arrays require continuous analysis by skilled personnel or by automatic algorithms in order to extract useable information. Typical pieces of information gained by analysis of infrasonic signals collected by multiple sensor arrays are arrival time, line of bearing, amplitude, and duration. These can all be used, often with significant accuracy, to locate sources. A very important part of this chain is associating collected signals across multiple arrays. Here, a pairwise, cross-beam coherence method of signal association is described that allows rapid signal association for high signal-to-noise ratio events captured by multiple infrasound arrays at ranges exceeding 150 km. Methods, test cases, and results are described.

Development of a novel ice-resistant semisubmersible drilling unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corona, E.N.; Schloerb, D.W.; Yashima, N.

1983-05-01

A multiyear program was initiated by ARCO Alaska, Inc. to assess the operational feasibility of drilling operations year-round in the ice-covered waters of the Bering, Chukchi, and Beaufort Seas. ARCO Alaska, Inc. is considering several alternative concepts for year-round drilling in the Bering Sea. One such concept, the Ice-Resistant Semisubmersible Drilling Unit, is a design concept of Mitsui Engineering and Shipbuilding Company. The design is intended to operate in broken, continuous, and ridged sea ice, and withstand severe open water sea conditions. The requirement to operate in two dissimilar environments results in a unit that is somewhat unusual when comparedmore » to typical semisubmersible drilling units.« less

Dot-gov: market failure and the creation of a national health information technology system.

PubMed

Kleinke, J D

2005-01-01

The U.S. health care marketplace's continuing failure to adopt information technology (IT) is the result of economic problems unique to health care, business strategy problems typical of fragmented industries, and technology standardization problems common to infrastructure development in free-market economies. Given the information intensity of medicine, the quality problems associated with inadequate IT, the magnitude of U.S. health spending, and the large federal share of that spending, this market failure requires aggressive governmental intervention. Federal policies to compel the creation of a national health IT system would reduce aggregate health care costs and improve quality, goals that cannot be attained in the health care marketplace.

Spacelab mission dependent training parametric resource requirements study

NASA Technical Reports Server (NTRS)

Ogden, D. H.; Watters, H.; Steadman, J.; Conrad, L.

1976-01-01

Training flows were developed for typical missions, resource relationships analyzed, and scheduling optimization algorithms defined. Parametric analyses were performed to study the effect of potential changes in mission model, mission complexity and training time required on the resource quantities required to support training of payload or mission specialists. Typical results of these analyses are presented both in graphic and tabular form.

Solar oxidation and removal of arsenic--Key parameters for continuous flow applications.

PubMed

Gill, L W; O'Farrell, C

2015-12-01

Solar oxidation to remove arsenic from water has previously been investigated as a batch process. This research has investigated the kinetic parameters for the design of a continuous flow solar reactor to remove arsenic from contaminated groundwater supplies. Continuous flow recirculated batch experiments were carried out under artificial UV light to investigate the effect of different parameters on arsenic removal efficiency. Inlet water arsenic concentrations of up to 1000 μg/L were reduced to below 10 μg/L requiring 12 mg/L iron after receiving 12 kJUV/L radiation. Citrate however was somewhat surprisingly found to promote a detrimental effect on the removal process in the continuous flow reactor studies which is contrary to results found in batch scale tests. The impact of other typical water groundwater quality parameters (phosphate and silica) on the process due to their competition with arsenic for photooxidation products revealed a much higher sensitivity to phosphate ions compared to silicate. Other results showed no benefit from the addition of TiO2 photocatalyst but enhanced arsenic removal at higher temperatures up to 40 °C. Overall, these results have indicated the kinetic envelope from which a continuous flow SORAS single pass system could be more confidently designed for a full-scale community groundwater application at a village level. Copyright © 2015 Elsevier Ltd. All rights reserved.

How much medicine do spine surgeons need to know to better select and care for patients?

PubMed Central

Epstein, Nancy E.

2012-01-01

Background: Although we routinely utilize medical consultants for preoperative clearance and postoperative patient follow-up, we as spine surgeons need to know more medicine to better select and care for our patients. Methods: This study provides additional medical knowledge to facilitate surgeons’ “cross-talk” with medical colleagues who are concerned about how multiple comorbid risk factors affect their preoperative clearance, and impact patients’ postoperative outcomes. Results: Within 6 months of an acute myocardial infarction (MI), patients undergoing urological surgery encountered a 40% mortality rate: similar rates may likely apply to patients undergoing spinal surgery. Within 6 weeks to 2 months of placing uncoated cardiac, carotid, or other stents, endothelialization is typically complete; as anti-platelet therapy may often be discontinued, spinal surgery can then be more safely performed. Coated stents, however, usually require 6 months to 1 year for endothelialization to occur; thus spinal surgery is often delayed as anti-platelet therapy must typically be continued to avoid thrombotic complications (e.g., stroke/MI). Diabetes and morbid obesity both increase the risk of postoperative infection, and poor wound healing, while the latter increases the risk of phlebitis/pulmonary embolism. Both hypercoagluation and hypocoagulation syndromes may require special preoperative testing/medications and/or transfusions of specific hematological factors. Pulmonary disease, neurological disorders, and major psychiatric pathology may also require further evaluations/therapy, and may even preclude successful surgical intervention. Conclusions: Although we as spinal surgeons utilize medical consultants for preoperative clearance and postoperative care, we need to know more medicine to better select and care for our patients. PMID:23248752

Embracing Safe Ground Test Facility Operations and Maintenance

NASA Technical Reports Server (NTRS)

Dunn, Steven C.; Green, Donald R.

2010-01-01

Conducting integrated operations and maintenance in wind tunnel ground test facilities requires a balance of meeting due dates, efficient operation, responsiveness to the test customer, data quality, effective maintenance (relating to readiness and reliability), and personnel and facility safety. Safety is non-negotiable, so the balance must be an "and" with other requirements and needs. Pressure to deliver services faster at increasing levels of quality in under-maintained facilities is typical. A challenge for management is to balance the "need for speed" with safety and quality. It s especially important to communicate this balance across the organization - workers, with a desire to perform, can be tempted to cut corners on defined processes to increase speed. Having a lean staff can extend the time required for pre-test preparations, so providing a safe work environment for facility personnel and providing good stewardship for expensive National capabilities can be put at risk by one well-intending person using at-risk behavior. This paper documents a specific, though typical, operational environment and cites management and worker safety initiatives and tools used to provide a safe work environment. Results are presented and clearly show that the work environment is a relatively safe one, though still not good enough to keep from preventing injury. So, the journey to a zero injury work environment - both in measured reality and in the minds of each employee - continues. The intent of this paper is to provide a benchmark for others with operational environments and stimulate additional sharing and discussion on having and keeping a safe work environment.

LEVERAGING AGING MATERIALS DATA TO SUPPORT EXTENSION OF TRANSPORTATION SHIPPING PACKAGES SERVICE LIFE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunn, K.; Bellamy, S.; Daugherty, W.

Nuclear material inventories are increasingly being transferred to interim storage locations where they may reside for extended periods of time. Use of a shipping package to store nuclear materials after the transfer has become more common for a variety of reasons. Shipping packages are robust and have a qualified pedigree for performance in normal operation and accident conditions but are only certified over an approved transportation window. The continued use of shipping packages to contain nuclear material during interim storage will result in reduced overall costs and reduced exposure to workers. However, the shipping package materials of construction must maintainmore » integrity as specified by the safety basis of the storage facility throughout the storage period, which is typically well beyond the certified transportation window. In many ways, the certification processes required for interim storage of nuclear materials in shipping packages is similar to life extension programs required for dry cask storage systems for commercial nuclear fuels. The storage of spent nuclear fuel in dry cask storage systems is federally-regulated, and over 1500 individual dry casks have been in successful service up to 20 years in the US. The uncertainty in final disposition will likely require extended storage of this fuel well beyond initial license periods and perhaps multiple re-licenses may be needed. Thus, both the shipping packages and the dry cask storage systems require materials integrity assessments and assurance of continued satisfactory materials performance over times not considered in the original evaluation processes. Test programs for the shipping packages have been established to obtain aging data on materials of construction to demonstrate continued system integrity. The collective data may be coupled with similar data for the dry cask storage systems and used to support extending the service life of shipping packages in both transportation and storage.« less

SAR (Synthetic Aperture Radar). Earth observing system. Volume 2F: Instrument panel report

NASA Technical Reports Server (NTRS)

1987-01-01

The scientific and engineering requirements for the Earth Observing System (EOS) imaging radar are provided. The radar is based on Shuttle Imaging Radar-C (SIR-C), and would include three frequencies: 1.25 GHz, 5.3 GHz, and 9.6 GHz; selectable polarizations for both transmit and receive channels; and selectable incidence angles from 15 to 55 deg. There would be three main viewing modes: a local high-resolution mode with typically 25 m resolution and 50 km swath width; a regional mapping mode with 100 m resolution and up to 200 km swath width; and a global mapping mode with typically 500 m resolution and up to 700 km swath width. The last mode allows global coverage in three days. The EOS SAR will be the first orbital imaging radar to provide multifrequency, multipolarization, multiple incidence angle observations of the entire Earth. Combined with Canadian and Japanese satellites, continuous radar observation capability will be possible. Major applications in the areas of glaciology, hydrology, vegetation science, oceanography, geology, and data and information systems are described.

Reducing the Environmental Impact of Clinical Laboratories.

PubMed

Lopez, Joseph B; Jackson, David; Gammie, Alistair; Badrick, Tony

2017-02-01

Healthcare is a significant contributor to environmental impact but this has received little attention. The typical laboratory uses far more energy and water per unit area than the typical office building. There is a need to sensitise laboratories to the importance of adopting good environmental practices. Since this comes at an initial cost, it is vital to obtain senior management support. Convincing management of the various tangible and intangible benefits that can accrue in the long run should help achieve this support. Many good environmental practices do not have a cost but will require a change in the culture and mind-set of the organisation. Continuing education and training are important keys to successful implementation of good practices. There is a need to undertake a rigorous cost-benefit analysis of every change that is introduced in going green. The adoption of good practices can eventually lead to ISO certification if this is desired. This paper provides suggestions that will allow a laboratory to start going green. It will allow the industry to enhance its corporate citizenship whilst improving its competitive advantage for long-term.

Target discrimination strategies in optics detection

NASA Astrophysics Data System (ADS)

Sjöqvist, Lars; Allard, Lars; Henriksson, Markus; Jonsson, Per; Pettersson, Magnus

2013-10-01

Detection and localisation of optical assemblies used for weapon guidance or sniper rifle scopes has attracted interest for security and military applications. Typically a laser system is used to interrogate a scene of interest and the retro-reflected radiation is detected. Different system approaches for area coverage can be realised ranging from flood illumination to step-and-stare or continuous scanning schemes. Independently of the chosen approach target discrimination is a crucial issue, particularly if a complex scene such as in an urban environment and autonomous operation is considered. In this work target discrimination strategies in optics detection are discussed. Typical parameters affecting the reflected laser radiation from the target are the wavelength, polarisation properties, temporal effects and the range resolution. Knowledge about the target characteristics is important to predict the target discrimination capability. Two different systems were used to investigate polarisation properties and range resolution information from targets including e.g. road signs, optical reflexes, rifle sights and optical references. The experimental results and implications on target discrimination will be discussed. If autonomous operation is required target discrimination becomes critical in order to reduce the number of false alarms.

Effective behavioral modeling and prediction even when few exemplars are available

NASA Astrophysics Data System (ADS)

Goan, Terrance; Kartha, Neelakantan; Kaneshiro, Ryan

2006-05-01

While great progress has been made in the lowest levels of data fusion, practical advances in behavior modeling and prediction remain elusive. The most critical limitation of existing approaches is their inability to support the required knowledge modeling and continuing refinement under realistic constraints (e.g., few historic exemplars, the lack of knowledge engineering support, and the need for rapid system deployment). This paper reports on our ongoing efforts to develop Propheteer, a system which will address these shortcomings through two primary techniques. First, with Propheteer we abandon the typical consensus-driven modeling approaches that involve infrequent group decision making sessions in favor of an approach that solicits asynchronous knowledge contributions (in the form of alternative future scenarios and indicators) without burdening the user with endless certainty or probability estimates. Second, we enable knowledge contributions by personnel beyond the typical core decision making group, thereby casting light on blind spots, mitigating human biases, and helping maintain the currency of the developed behavior models. We conclude with a discussion of the many lessons learned in the development of our prototype Propheteer system.

Parameter Invariance and Skill Attribute Continuity in the DINA Model

ERIC Educational Resources Information Center

Bolt, Daniel M.; Kim, Jee-Seon

2018-01-01

Cognitive diagnosis models (CDMs) typically assume skill attributes with discrete (often binary) levels of skill mastery, making the existence of skill continuity an anticipated form of model misspecification. In this article, misspecification due to skill continuity is argued to be of particular concern for several CDM applications due to the…

Out-of-autoclave manufacturing of a stiffened thermoplastic carbon fibre PEEK panel

NASA Astrophysics Data System (ADS)

Flanagan, M.; Goggins, J.; Doyle, A.; Weafer, B.; Ward, M.; Bizeul, M.; Canavan, R.; O'Bradaigh, C.; Doyle, K.; Harrison, N.

2017-10-01

Out-of-Autoclave manufacturing methods, specifically Automated Tape Placement (ATP) and induction welding, used in the fabrication of a stiffened thermoplastic demonstrator panel, are presented in this study. The demonstrator panel consists of two stiffeners induction welded to a flat skin, to form a typical load bearing aerospace sub-component. The skin of the panel is manufactured from uni-directional Carbon Fibre (CF) Polyetheretherkeytone (PEEK) using laser assisted Automated Tape Placement (ATP) and the stiffeners are press formed from woven CF-PEEK. The stiffeners are fusion bonded to the skin using a continuous induction welding process. A susceptor material is used at the interface to ensure the required heating is concentrated at the weldline. Microscopy was used to examine the manufactured coupons for defects. Destructive testing was carried out to evaluate the strength of the overall assembly. The work shows that assemblies manufactured using continuous induction welding and ATP are suitable for load bearing aerospace applications.

Continuous welding of unidirectional fiber reinforced thermoplastic tape material

NASA Astrophysics Data System (ADS)

Schledjewski, Ralf

2017-10-01

Continuous welding techniques like thermoplastic tape placement with in situ consolidation offer several advantages over traditional manufacturing processes like autoclave consolidation, thermoforming, etc. However, still there is a need to solve several important processing issues before it becomes a viable economic process. Intensive process analysis and optimization has been carried out in the past through experimental investigation, model definition and simulation development. Today process simulation is capable to predict resulting consolidation quality. Effects of material imperfections or process parameter variations are well known. But using this knowledge to control the process based on online process monitoring and according adaption of the process parameters is still challenging. Solving inverse problems and using methods for automated code generation allowing fast implementation of algorithms on targets are required. The paper explains the placement technique in general. Process-material-property-relationships and typical material imperfections are described. Furthermore, online monitoring techniques and how to use them for a model based process control system are presented.

Interprofessional education about patient decision support in specialty care.

PubMed

Politi, Mary C; Pieterse, Arwen H; Truant, Tracy; Borkhoff, Cornelia; Jha, Vikram; Kuhl, Laura; Nicolai, Jennifer; Goss, Claudia

2011-11-01

Specialty care involves services provided by health professionals who focus on treating diseases affecting one body system. In contrast to primary care - aimed at providing continuous, comprehensive care - specialty care often involves intermittent episodes of care focused around specific medical conditions. In addition, it typically includes multiple providers who have unique areas of expertise that are important in supporting patients' care. Interprofessional care involves multiple professionals from different disciplines collaborating to provide an integrated approach to patient care. For patients to experience continuity of care across interprofessional providers, providers need to communicate and maintain a shared sense of responsibility to their patients. In this article, we describe challenges inherent in providing interprofessional patient decision support in specialty care. We propose ways for providers to engage in interprofessional decision support and discuss promising approaches to teaching an interprofessional decision support to specialty care providers. Additional evaluation and empirical research are required before further recommendations can be made about education for interprofessional decision support in specialty care.

Lessons Learned from a Student-Led Breastfeeding Support Initiative at a US Urban Public University.

PubMed

Dinour, Lauren M; Beharie, Nisha

2015-08-01

Despite US laws requiring most workplaces to provide "reasonable" unpaid break time and a private space for female employees to express breast milk, much of the statutory language is vague and open to interpretation, potentially leading to suboptimal implementation. College and university campuses in the US represent a particular concern, as students are typically not employed by their school and thus not protected by state and federal labor laws. This article describes the work of 2 graduate students to successfully establish a dedicated space at their US urban public university for the purpose of expressing breast milk. A 3-pronged strategy was implemented to create a dedicated lactation space: (1) collecting data to support the establishment of the room, (2) raising awareness of legislation related to protection of breastfeeding, and (3) community organizing and advocacy. After nearly 18 months of advocacy and planning, the campus' dedicated lactation room was opened for use in March 2012. Two years later, the room remains a valuable resource and is used, on average, 8.4 times per weekday during a typical school week. Several lessons learned are described, and the strategies employed can be tested and applied in other US academic settings to assist in advocating for more supports for breastfeeding mothers. However, it is also imperative that US legislation be amended to include language that explicitly protects students so that women do not need to make the choice between continuing their education and continuing to breastfeed. © The Author(s) 2015.

Mitigating Structural Defects in Droop-Minimizing InGaN/GaN Quantum Well Heterostructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Zhibo; Chesin, Jordan; Singh, Akshay

2016-12-01

Modern commercial InGaN/GaN blue LEDs continue to suffer from efficiency droop, a reduction in efficiency with increasing drive current. External quantum efficiency (EQE) typically peaks at low drive currents (< 10 A cm 2) and drops monotonically at higher current densities, falling to <85% of the peak EQE at a drive current of 100 A cm 2. Mitigating droop-related losses will yield tremendous gains in both luminous efficacy (lumens/W) and cost (lumens/$). Such improvements are critical for continued large-scale market penetration of LED technologies, particularly in high-power and high flux per unit area applications. However, device structures that reduce droopmore » typically require higher indium content and are accompanied by a corresponding degradation in material quality which negates the droop improvement via enhanced Shockley-Read-Hall (SRH) recombination. In this work, we use advanced characterization techniques to identify and classify structural defects in InGaN/GaN quantum well (QW) heterostructures that share features with low-droop designs. Using aberration-corrected scanning transmission electron microscopy (C s-STEM), we find the presence of severe well width fluctuations (WWFs) in a number of low droop device architectures. However, the presence of WWFs does not correlate strongly with external quantum efficiency nor defect densities measured via deep level optical spectroscopy (DLOS). Hence, performance losses in the heterostructures of interest are likely dominated by nanoscale point or interfacial defects rather than large-scale extended defects.« less

Guidance on the Stand Down, Mothball, and Reactivation of Ground Test Facilities

NASA Technical Reports Server (NTRS)

Volkman, Gregrey T.; Dunn, Steven C.

2013-01-01

The development of aerospace and aeronautics products typically requires three distinct types of testing resources across research, development, test, and evaluation: experimental ground testing, computational "testing" and development, and flight testing. Over the last twenty plus years, computational methods have replaced some physical experiments and this trend is continuing. The result is decreased utilization of ground test capabilities and, along with market forces, industry consolidation, and other factors, has resulted in the stand down and oftentimes closure of many ground test facilities. Ground test capabilities are (and very likely will continue to be for many years) required to verify computational results and to provide information for regimes where computational methods remain immature. Ground test capabilities are very costly to build and to maintain, so once constructed and operational it may be desirable to retain access to those capabilities even if not currently needed. One means of doing this while reducing ongoing sustainment costs is to stand down the facility into a "mothball" status - keeping it alive to bring it back when needed. Both NASA and the US Department of Defense have policies to accomplish the mothball of a facility, but with little detail. This paper offers a generic process to follow that can be tailored based on the needs of the owner and the applicable facility.

Real-time imaging through strongly scattering media: seeing through turbid media, instantly

PubMed Central

Sudarsanam, Sriram; Mathew, James; Panigrahi, Swapnesh; Fade, Julien; Alouini, Mehdi; Ramachandran, Hema

2016-01-01

Numerous everyday situations like navigation, medical imaging and rescue operations require viewing through optically inhomogeneous media. This is a challenging task as photons propagate predominantly diffusively (rather than ballistically) due to random multiple scattering off the inhomogenieties. Real-time imaging with ballistic light under continuous-wave illumination is even more challenging due to the extremely weak signal, necessitating voluminous data-processing. Here we report imaging through strongly scattering media in real-time and at rates several times the critical flicker frequency of the eye, so that motion is perceived as continuous. Two factors contributed to the speedup of more than three orders of magnitude over conventional techniques - the use of a simplified algorithm enabling processing of data on the fly, and the utilisation of task and data parallelization capabilities of typical desktop computers. The extreme simplicity of the technique, and its implementation with present day low-cost technology promises its utility in a variety of devices in maritime, aerospace, rail and road transport, in medical imaging and defence. It is of equal interest to the common man and adventure sportsperson like hikers, divers, mountaineers, who frequently encounter situations requiring realtime imaging through obscuring media. As a specific example, navigation under poor visibility is examined. PMID:27114106

Screening and Spectral Summing of LANL Empty Waste Drums - 13226

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gruetzmacher, Kathleen M.; Bustos, Roland M.; Ferran, Scott G.

2013-07-01

Empty 55-gallon drums that formerly held transuranic (TRU) waste (often over-packed in 85- gallon drums) are generated at LANL and require radiological characterization for disposition. These drums are typically measured and analyzed individually using high purity germanium (HPGe) gamma detectors. This approach can be resource and time intensive. For a project requiring several hundred drums to be characterized in a short time frame, an alternative approach was developed. The approach utilizes a combination of field screening and spectral summing that was required to be technically defensible and meet the Nevada Nuclear Security Site (NNSS) Waste Acceptance Criteria (WAC). In themore » screening phase of the operation, the drums were counted for 300 seconds (compared to 600 seconds for the typical approach) and checked against Low Level (LL)/TRU thresholds established for each drum configuration and detector. Multiple TRU nuclides and multiple gamma rays for each nuclide were evaluated using an automated spreadsheet utility that can process data from up to 42 drums at a time. Screening results were reviewed by an expert analyst to confirm the field LL/TRU determination. The spectral summing analysis technique combines spectral data (channel-by-channel) associated with a group of individual waste containers producing a composite spectrum. The grouped drums must meet specific similarity criteria. Another automated spreadsheet utility was used to spectral sum data from an unlimited number of similar drums grouped together. The composite spectrum represents a virtual combined drum for the group of drums and was analyzed using the SNAP{sup TM}/Radioassay Data Sheet (RDS)/Batch Data Report (BDR) method. The activity results for a composite virtual drum were divided equally amongst the individual drums to generate characterization results for each individual drum in the group. An initial batch of approximately 500 drums were measured and analyzed in less than 2 months in 2011. A second batch of approximately 500 more drums were measured and analyzed during the following 2 1/2 months. Four different HPGe detectors were employed for the operation. The screening and spectral summing approach can reduce the overall measurement and analysis time required. However, developing the technical details and automation spreadsheets requires a significant amount of expert time prior to beginning field operations and must be considered in the overall project schedule. This approach has continued to be used for characterizing several hundred more empty drums in 2012 and is planned to continue in 2013. (authors)« less

A Novel Estimator for the Rate of Information Transfer by Continuous Signals

PubMed Central

Takalo, Jouni; Ignatova, Irina; Weckström, Matti; Vähäsöyrinki, Mikko

2011-01-01

The information transfer rate provides an objective and rigorous way to quantify how much information is being transmitted through a communications channel whose input and output consist of time-varying signals. However, current estimators of information content in continuous signals are typically based on assumptions about the system's linearity and signal statistics, or they require prohibitive amounts of data. Here we present a novel information rate estimator without these limitations that is also optimized for computational efficiency. We validate the method with a simulated Gaussian information channel and demonstrate its performance with two example applications. Information transfer between the input and output signals of a nonlinear system is analyzed using a sensory receptor neuron as the model system. Then, a climate data set is analyzed to demonstrate that the method can be applied to a system based on two outputs generated by interrelated random processes. These analyses also demonstrate that the new method offers consistent performance in situations where classical methods fail. In addition to these examples, the method is applicable to a wide range of continuous time series commonly observed in the natural sciences, economics and engineering. PMID:21494562

Understanding the use of continuous oscillating positive airway pressure (bubble CPAP) to treat neonatal respiratory disease: an engineering approach.

PubMed

Manilal-Reddy, P I; Al-Jumaily, A M

2009-01-01

A continuous oscillatory positive airway pressure with pressure oscillations incidental to the mean airway pressure (bubble CPAP) is defined as a modified form of traditional continuous positive airway pressure (CPAP) delivery where pressure oscillations in addition to CPAP are administered to neonates with lung diseases. The mechanical effect of the pressure oscillations on lung performance is investigated by formulating mathematical models of a typical bubble CPAP device and a simple representation of a neonatal respiratory system. Preliminary results of the respiratory system's mechanical response suggest that bubble CPAP may improve lung performance by minimizing the respiratory system impedance and that the resonant frequency of the respiratory system may be a controlling factor. Additional steps in terms of clinical trials and a more complex respiratory system model are required to gain a deeper insight into the mechanical receptiveness of the respiratory system to pressure oscillations. However, the current results are promising in that they offer a deeper insight into the trends of variations that can be expected in future extended models as well as the model philosophies that need to be adopted to produce results that are compatible with experimental verification.

Minimizing Noise in Pediatric Task-Based functional MRI; Adolescents with Developmental Disabilities and Typical Development

PubMed Central

Fassbender, Catherine; Muhkerjee, Prerona; Schweitzer, Julie B.

2017-01-01

Functional Magnetic Resonance Imaging (fMRI) represents a powerful tool with which to examine brain functioning and development in typically developing pediatric groups as well as children and adolescents with clinical disorders. However, fMRI data can be highly susceptible to misinterpretation due to the effects of excessive levels of noise, often related to head motion. Imaging children, especially with developmental disorders, requires extra considerations related to hyperactivity, anxiety and the ability to perform and maintain attention to the fMRI paradigm. We discuss a number of methods that can be employed to minimize noise, in particular movement-related noise. To this end we focus on strategies prior to, during and following the data acquisition phase employed primarily within our own laboratory. We discuss the impact of factors such as experimental design, screening of potential participants and pre-scan training on head motion in our adolescents with developmental disorders and typical development. We make some suggestions that may minimize noise during data acquisition itself and finally we briefly discuss some current processing techniques that may help to identify and remove noise in the data. Many advances have been made in the field of pediatric imaging, particularly with regard to research involving children with developmental disorders. Mindfulness of issues such as those discussed here will ensure continued progress and greater consistency across studies. PMID:28130195

Measuring Several Aspects of Attention in One Test: The Factor Structure of Conners's Continuous Performance Test

ERIC Educational Resources Information Center

Egeland, Jens; Kovalik-Gran, Iwona

2010-01-01

Objective: Continuous performance tests are known to typically measure sustained attention but usually also yield parameters that potentially measure other subprocesses of attention. The aim of the present study was to test the factor structure of the Conners's Continuous Performance Test (CCPT) in a heterogeneous clinical sample consisting of…

7 CFR 1944.407 - Limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.407 Limitations. The amount of... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... typical needed repairs, and the cost savings between self-help and contractor rehabilitation and repair...

Computation Error Analysis: Students with Mathematics Difficulty Compared to Typically Achieving Students

ERIC Educational Resources Information Center

Nelson, Gena; Powell, Sarah R.

2018-01-01

Though proficiency with computation is highly emphasized in national mathematics standards, students with mathematics difficulty (MD) continue to struggle with computation. To learn more about the differences in computation error patterns between typically achieving students and students with MD, we assessed 478 third-grade students on a measure…

Anti-backlash drive systems for multi-degree freedom devices

DOEpatents

Tsai, Lung-Wen; Chang, Sun-Lai

1993-01-01

A new and innovative concept for the control of backlash in gear-coupled transmission mechanisms. The concept utilizes redundant unidirectional drives to assure positive coupling of gear meshes at all times. Based on this concept, a methodology for the enumeration of admissible redundant-drive backlash-free robotic mechanisms has been established. Some typical two- and three-DOF mechanisms are disclosed. Furthermore, actuator torques have been derived as functions of either joint torques or end-effector dynamic performance requirements. A redundantly driven gear coupled transmission mechanism manipulator has a fail-safe advantage in that, except of the loss of backlash control, it can continue to function when one of its actuators fails. A two-DOF backlash-free arm has been reduced to practice to demonstrate the principle.

NASA and ESA Collaboration on Hexavalent Chrome Alternatives Pretreatments Only Interim Test Report

NASA Technical Reports Server (NTRS)

Kessel, Kurt R.

2015-01-01

NASA and ESA continue to search for an alternative to hexavalent chromium in coatings applications that meet their performance requirements in corrosion protection, cost, operability, and health and safety, while typically specifying that performance must be equal to or greater than existing systems. The overall objective of the collaborative effort between NASA TEERM and ESA is to test and evaluate coating systems (pretreatments, pretreatments with primer, and pretreatments with primer and topcoat) as replacements for hexavalent chrome coatings in aerospace applications. This objective will be accomplished by testing promising coatings identified from previous NASA, ESA, Department of Defense (DOD), and other project experience. Additionally, several new materials will be analyzed according to ESA-identified specifications.

A study of swing-curve physics in diffraction-based overlay

NASA Astrophysics Data System (ADS)

Bhattacharyya, Kaustuve; den Boef, Arie; Storms, Greet; van Heijst, Joost; Noot, Marc; An, Kevin; Park, Noh-Kyoung; Jeon, Se-Ra; Oh, Nang-Lyeom; McNamara, Elliott; van de Mast, Frank; Oh, SeungHwa; Lee, Seung Yoon; Hwang, Chan; Lee, Kuntack

2016-03-01

With the increase of process complexity in advanced nodes, the requirements of process robustness in overlay metrology continues to tighten. Especially with the introduction of newer materials in the film-stack along with typical stack variations (thickness, optical properties, profile asymmetry etc.), the signal formation physics in diffraction-based overlay (DBO) becomes an important aspect to apply in overlay metrology target and recipe selection. In order to address the signal formation physics, an effort is made towards studying the swing-curve phenomena through wavelength and polarizations on production stacks using simulations as well as experimental technique using DBO. The results provide a wealth of information on target and recipe selection for robustness. Details from simulation and measurements will be reported in this technical publication.

The Corporate University Model for Continuous Learning, Training and Development.

ERIC Educational Resources Information Center

El-Tannir, Akram A.

2002-01-01

Corporate universities typically convey corporate culture and provide systematic curriculum aimed at achieving strategic objectives. Virtual access and company-specific content combine to provide opportunities for continuous and active learning, a model that is becoming pervasive. (Contains 17 references.) (SK)

Dynamic, continuous multitasking training leads to task-specific improvements but does not transfer across action selection tasks

NASA Astrophysics Data System (ADS)

Bender, Angela D.; Filmer, Hannah L.; Naughtin, Claire K.; Dux, Paul E.

2017-12-01

The ability to perform multiple tasks concurrently is an ever-increasing requirement in our information-rich world. Despite this, multitasking typically compromises performance due to the processing limitations associated with cognitive control and decision-making. While intensive dual-task training is known to improve multitasking performance, only limited evidence suggests that training-related performance benefits can transfer to untrained tasks that share overlapping processes. In the real world, however, coordinating and selecting several responses within close temporal proximity will often occur in high-interference environments. Over the last decade, there have been notable reports that training on video action games that require dynamic multitasking in a demanding environment can lead to transfer effects on aspects of cognition such as attention and working memory. Here, we asked whether continuous and dynamic multitasking training extends benefits to tasks that are theoretically related to the trained tasks. To examine this issue, we asked a group of participants to train on a combined continuous visuomotor tracking task and a perceptual discrimination task for six sessions, while an active control group practiced the component tasks in isolation. A battery of tests measuring response selection, response inhibition, and spatial attention was administered before and immediately after training to investigate transfer. Multitasking training resulted in substantial, task-specific gains in dual-task ability, but there was no evidence that these benefits generalized to other action control tasks. The findings suggest that training on a combined visuomotor tracking and discrimination task results in task-specific benefits but provides no additional value for untrained action selection tasks.

Clean focus, dose and CD metrology for CD uniformity improvement

NASA Astrophysics Data System (ADS)

Lee, Honggoo; Han, Sangjun; Hong, Minhyung; Kim, Seungyoung; Lee, Jieun; Lee, DongYoung; Oh, Eungryong; Choi, Ahlin; Kim, Nakyoon; Robinson, John C.; Mengel, Markus; Pablo, Rovira; Yoo, Sungchul; Getin, Raphael; Choi, Dongsub; Jeon, Sanghuck

2018-03-01

Lithography process control solutions require more exacting capabilities as the semiconductor industry goes forward to the 1x nm node DRAM device manufacturing. In order to continue scaling down the device feature sizes, critical dimension (CD) uniformity requires continuous improvement to meet the required CD error budget. In this study we investigate using optical measurement technology to improve over CD-SEM methods in focus, dose, and CD. One of the key challenges is measuring scanner focus of device patterns. There are focus measurement methods based on specially designed marks on scribe-line, however, one issue of this approach is that it will report focus of scribe line which is potentially different from that of the real device pattern. In addition, scribe-line marks require additional design and troubleshooting steps that add complexity. In this study, we investigated focus measurement directly on the device pattern. Dose control is typically based on using the linear correlation behavior between dose and CD. The noise of CD measurement, based on CD-SEM for example, will not only impact the accuracy, but also will make it difficult to monitor dose signature on product wafers. In this study we will report the direct dose metrology result using an optical metrology system which especially enhances the DUV spectral coverage to improve the signal to noise ratio. CD-SEM is often used to measure CD after the lithography step. This measurement approach has the advantage of easy recipe setup as well as the flexibility to measure critical feature dimensions, however, we observe that CD-SEM metrology has limitations. In this study, we demonstrate within-field CD uniformity improvement through the extraction of clean scanner slit and scan CD behavior by using optical metrology.

Cognitive Improvement of Attention and Inhibition in the Late Afternoon in Children With Attention-Deficit Hyperactivity Disorder (ADHD) Treated With Osmotic-Release Oral System Methylphenidate.

PubMed

Slama, Hichem; Fery, Patrick; Verheulpen, Denis; Vanzeveren, Nathalie; Van Bogaert, Patrick

2015-07-01

Long-acting medications have been developed and approved for use in the treatment of attention-deficit hyperactivity disorder (ADHD). These compounds are intended to optimize and maintain symptoms control throughout the day. We tested prolonged effects of osmotic-release oral system methylphenidate on both attention and inhibition, in the late afternoon. A double-blind, randomized, placebo-controlled study was conducted in 36 boys (7-12 years) with ADHD and 40 typically developing children. The ADHD children received an individualized dose of placebo or osmotic-release oral system methylphenidate. They were tested about 8 hours after taking with 2 continuous performance tests (continuous performance test-X [CPT-X] and continuous performance test-AX [CPT-AX]) and a counting Stroop. A positive effect of osmotic-release oral system methylphenidate was present in CPT-AX with faster and less variable reaction times under osmotic-release oral system methylphenidate than under placebo, and no difference with typically developing children. In the counting Stroop, we found a decreased interference with osmotic-release oral system methylphenidate but no difference between children with ADHD under placebo and typically developing children. © The Author(s) 2014.

Optimal post-experiment estimation of poorly modeled dynamic systems

NASA Technical Reports Server (NTRS)

Mook, D. Joseph

1988-01-01

Recently, a novel strategy for post-experiment state estimation of discretely-measured dynamic systems has been developed. The method accounts for errors in the system dynamic model equations in a more general and rigorous manner than do filter-smoother algorithms. The dynamic model error terms do not require the usual process noise assumptions of zero-mean, symmetrically distributed random disturbances. Instead, the model error terms require no prior assumptions other than piecewise continuity. The resulting state estimates are more accurate than filters for applications in which the dynamic model error clearly violates the typical process noise assumptions, and the available measurements are sparse and/or noisy. Estimates of the dynamic model error, in addition to the states, are obtained as part of the solution of a two-point boundary value problem, and may be exploited for numerous reasons. In this paper, the basic technique is explained, and several example applications are given. Included among the examples are both state estimation and exploitation of the model error estimates.

1393 Ring Bus at JPL: Description and Status

NASA Technical Reports Server (NTRS)

Wysocky, Terry R.

2007-01-01

Completed Ring Bus IC V&V Phase - Ring Bus Test Plan Completed for SIM Project - Applicable to Other Projects Implemented a Avionics Bus Based upon the IEEE 1393 Standard - Excellent Starting Point for a General Purpose High-Speed Spacecraft Bus - Designed to Meet SIM Requirements for - Real-time deterministic, distributed systems. - Control system requirements - Fault detection and recovery Other JPL Projects Considering Implementation F'light Software Ring Bus Driver Module Began in 2006, Continues Participating in Standard Revision. Search for Earth-like planets orbiting nearby stars and measure the masses and orbits of the planets it finds. Survey 2000 nearby stars for planetary systems to learn whether our Solar System is unusual, or typical. Make a new catalog of star position 100 times more accurate than current measurements. Learn how our galaxy formed and will evolve by studying the dynamics of its stars. Critically test models of exactly how stars shine, including exotic objects like black holes, neutron stars and white dwarfs.

Continued Data Acquisition Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwellenbach, David

This task focused on improving techniques for integrating data acquisition of secondary particles correlated in time with detected cosmic-ray muons. Scintillation detectors with Pulse Shape Discrimination (PSD) capability show the most promise as a detector technology based on work in FY13. Typically PSD parameters are determined prior to an experiment and the results are based on these parameters. By saving data in list mode, including the fully digitized waveform, any experiment can effectively be replayed to adjust PSD and other parameters for the best data capture. List mode requires time synchronization of two independent data acquisitions (DAQ) systems: the muonmore » tracker and the particle detector system. Techniques to synchronize these systems were studied. Two basic techniques were identified: real time mode and sequential mode. Real time mode is the preferred system but has proven to be a significant challenge since two FPGA systems with different clocking parameters must be synchronized. Sequential processing is expected to work with virtually any DAQ but requires more post processing to extract the data.« less

Subsurface Monitoring of CO2 Sequestration - A Review and Look Forward

NASA Astrophysics Data System (ADS)

Daley, T. M.

2012-12-01

The injection of CO2 into subsurface formations is at least 50 years old with large-scale utilization of CO2 for enhanced oil recovery (CO2-EOR) beginning in the 1970s. Early monitoring efforts had limited measurements in available boreholes. With growing interest in CO2 sequestration beginning in the 1990's, along with growth in geophysical reservoir monitoring, small to mid-size sequestration monitoring projects began to appear. The overall goals of a subsurface monitoring plan are to provide measurement of CO2 induced changes in subsurface properties at a range of spatial and temporal scales. The range of spatial scales allows tracking of the location and saturation of the plume with varying detail, while finer temporal sampling (up to continuous) allows better understanding of dynamic processes (e.g. multi-phase flow) and constraining of reservoir models. Early monitoring of small scale pilots associated with CO2-EOR (e.g., the McElroy field and the Lost Hills field), developed many of the methodologies including tomographic imaging and multi-physics measurements. Large (reservoir) scale sequestration monitoring began with the Sleipner and Weyburn projects. Typically, large scale monitoring, such as 4D surface seismic, has limited temporal sampling due to costs. Smaller scale pilots can allow more frequent measurements as either individual time-lapse 'snapshots' or as continuous monitoring. Pilot monitoring examples include the Frio, Nagaoka and Otway pilots using repeated well logging, crosswell imaging, vertical seismic profiles and CASSM (continuous active-source seismic monitoring). For saline reservoir sequestration projects, there is typically integration of characterization and monitoring, since the sites are not pre-characterized resource developments (oil or gas), which reinforces the need for multi-scale measurements. As we move beyond pilot sites, we need to quantify CO2 plume and reservoir properties (e.g. pressure) over large scales, while still obtaining high resolution. Typically the high-resolution (spatial and temporal) tools are deployed in permanent or semi-permanent borehole installations, where special well design may be necessary, such as non-conductive casing for electrical surveys. Effective utilization of monitoring wells requires an approach of modular borehole monitoring (MBM) were multiple measurements can be made. An example is recent work at the Citronelle pilot injection site where an MBM package with seismic, fluid sampling and distributed fiber sensing was deployed. For future large scale sequestration monitoring, an adaptive borehole-monitoring program is proposed.

'For me it's about not feeling like I'm on a diet': a thematic analysis of women's experiences of an intermittent energy restricted diet to reduce breast cancer risk.

PubMed

Donnelly, L S; Shaw, R L; Pegington, M; Armitage, C J; Evans, D G; Howell, A; Harvie, M N

2018-06-21

Weight-loss programmes requiring intermittent energy restriction offer an alternative to continuous energy restriction programmes that typically have low adherence. We reported greater weight loss, better adherence and spontaneous reduced energy intake on healthy eating days with intermittent as opposed to continuous energy restriction. The present study aims to explore why intermittent energy restriction diets exert these positive effects. Semi-structured interviews were carried out with 13 women aged 39-62 years, who followed a 4-month intermittent energy restriction (2 days of low energy/low carbohydrate, 5 days of healthy eating). Nine of the 13 women successfully lost >5% of their total body weight. Data were analysed using thematic analysis. The intermittent regimen redefined the meaning of dieting and normal eating. Women reconceptualised dieting as only two low energy days per week, even though this often differed from their pre-diet eating patterns. Women reported that they could adhere more closely to the rules of the intermittent diet compared to previously attempted continuous diets. They found that the intermittent diet was less cognitively demanding because the restrictive and clear rules of the intermittent diet were easier to understand and easier to follow than with continuous dieting. Many participants found intermittent dieting preferable to previous experiences of continuous dieting. The findings provide some insight into the ways in which intermittent dieting is successful, and why it could be considered a viable alternative to continuous energy restriction for weight loss. © 2018 The British Dietetic Association Ltd.

A mathematical approach for evaluating Markov models in continuous time without discrete-event simulation.

PubMed

van Rosmalen, Joost; Toy, Mehlika; O'Mahony, James F

2013-08-01

Markov models are a simple and powerful tool for analyzing the health and economic effects of health care interventions. These models are usually evaluated in discrete time using cohort analysis. The use of discrete time assumes that changes in health states occur only at the end of a cycle period. Discrete-time Markov models only approximate the process of disease progression, as clinical events typically occur in continuous time. The approximation can yield biased cost-effectiveness estimates for Markov models with long cycle periods and if no half-cycle correction is made. The purpose of this article is to present an overview of methods for evaluating Markov models in continuous time. These methods use mathematical results from stochastic process theory and control theory. The methods are illustrated using an applied example on the cost-effectiveness of antiviral therapy for chronic hepatitis B. The main result is a mathematical solution for the expected time spent in each state in a continuous-time Markov model. It is shown how this solution can account for age-dependent transition rates and discounting of costs and health effects, and how the concept of tunnel states can be used to account for transition rates that depend on the time spent in a state. The applied example shows that the continuous-time model yields more accurate results than the discrete-time model but does not require much computation time and is easily implemented. In conclusion, continuous-time Markov models are a feasible alternative to cohort analysis and can offer several theoretical and practical advantages.

Strategies for the startup of methanogenic inverse fluidized-bed reactors using colonized particles.

PubMed

Alvarado-Lassman, A; Sandoval-Ramos, A; Flores-Altamirano, M G; Vallejo-Cantú, N A; Méndez-Contreras, J M

2010-05-01

One of the inconveniences in the startup of methanogenic inverse fluidized-bed reactors (IFBRs) is the long period required for biofilm formation and stabilization of the system. Previous researchers have preferred to start up in batch mode to shorten stabilization times. Much less work has been done with continuous-mode startup for the IFBR configuration of reactors. In this study, we prepared two IFBRs with similar characteristics to compare startup times for batch- and continuous-operation modes. The reactors were inoculated with a small quantity of colonized particles and run for a period of 3 months, to establish the optimal startup strategy using synthetic media as a substrate (glucose as a source of carbon). After the startup stage, the continuous- and batch-mode reactors removed more than 80% of the chemical oxygen demand (COD) in 51 and 60 days of operation, respectively; however, at the end of the experiments, the continuous-mode reactor had more biomass attached to the support media than the batch-mode reactor. Both reactors developed fully covered support media, but only the continuous-mode reactor had methane yields close to the theoretical value that is typical of stable reactors. Then, a combined startup strategy was proposed, with industrial wastewater as the substrate, using a sequence of batch cycles followed by continuous operation, which allows stable operation at an organic loading rate of 20 g COD/L x d in 15 days. Using a fraction of colonized support as an inoculum presents advantages, with respect to previously reported strategies.

Continuous-flow water sampler for real-time isotopic water measurements

NASA Astrophysics Data System (ADS)

Carter, J.; Dennis, K.

2013-12-01

Measuring the stable isotopes of liquid water (δ18O and δD) is a tool familiar to many Earth scientists, but most current techniques require discrete sampling. For example, isotope ratio mass spectrometry requires the collection of aliquots of water that are then converted to CO2, CO or H2 for analysis. Similarly, laser-based techniques, such as Cavity Ring-Down Spectroscopy (CRDS) convert discrete samples (typically < 2μL) of liquid water to water vapor using a flash vaporization process. By requiring the use of discrete samples fine-scale spatial and temporal studies of changes in δ18O and δD are limited. Here we present a continuous-flow water sampler that will enable scientists to probe isotopic changes in real-time, with applications including, but not limited to, quantification of the 'amount effect' (Dansgaard, 1964) during an individual precipitation event or storm track, real-time mixing of water in river systems, and shipboard continuous water measurements (Munksgaard et al., 2012). Due to the inherent ability of CRDS to measure a continuous flow of water vapor it is an ideal candidate for interfacing with a continuous water sampling system. Here we present results from the first commercially available continuous-flow water sampler, developed by engineers at Picarro. This peripheral device is compatible with Picarro CRDS isotopic water analyzers, allowing real-time, continuous isotopic measurements of liquid water. The new device, which expands upon the design of Munskgaard et al. (2011), utilizes expanded polytetrafluoroethylene (ePTFE) membrane technology to continuously generate gas-phase water, while liquid water is pumped through the system. The water vapor subsequently travels to the CRDS analyzer where the isotopic ratios are measured and recorded. The generation of water vapor using membrane technology is sensitive to environmental conditions, which if not actively control, lead to sustainable experimental noise and drift. Consequently, our continuous-flow water sample employs active control for all pertinent parameters, significantly increasing its stability and usability. We will present data from controlled laboratory experiments demonstrating sample-to-sample precision and long-term stability. We will also show experimental data that highlights the instrumental sample-to-sample memory, which we have decreased significantly from previous implementations of this technology. Additionally, we will present field results from the Sacramento River, CA. Dansgaard, W. (1964) 'Stable isotopes in precipitation', Tellus, 16(4), p. 436-468. Munksgaard, N.C., Wurster, C.M., Bass, A., Zagorskis, I., and Bird, M.I. (2012) 'First continuous shipboard d18O and dD measurements in seawater by diffusion sampling--cavity ring-down spectrometry', Environmental Chemistry Letters, 10, p.301-307. Munksgaard, N.C., Wurster, C.M., and Bird, M.I., (2011), 'Continuous analysis of δ18O and δD values of water by diffusion sampling cavity ring-down spectrometry: a novel sampling device for unattended field monitoring of precipitation, ground and surface waters', Rapid Communications in Mass Spectrometry, 25, p. 3706-3712.

Evaluation of ultra-low background materials for uranium and thorium using ICP-MS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoppe, E. W.; Overman, N. R.; LaFerriere, B. D.

2013-08-08

An increasing number of physics experiments require low background materials for their construction. The presence of Uranium and Thorium and their progeny in these materials present a variety of unwanted background sources for these experiments. The sensitivity of the experiments continues to drive the necessary levels of detection ever lower as well. This requirement for greater sensitivity has rendered direct radioassay impractical in many cases requiring large quantities of material, frequently many kilograms, and prolonged counting times, often months. Other assay techniques have been employed such as Neutron Activation Analysis but this requires access to expensive facilities and instrumentation andmore » can be further complicated and delayed by the formation of unwanted radionuclides. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is a useful tool and recent advancements have increased the sensitivity particularly in the elemental high mass range of U and Th. Unlike direct radioassay, ICP-MS is a destructive technique since it requires the sample to be in liquid form which is aspirated into a high temperature plasma. But it benefits in that it usually requires a very small sample, typically about a gram. This paper discusses how a variety of low background materials such as copper, polymers, and fused silica are made amenable to ICP-MS assay and how the arduous task of maintaining low backgrounds of U and Th is achieved.« less

Evaluation of Ultra-Low Background Materials for Uranium and Thorium Using ICP-MS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoppe, Eric W.; Overman, Nicole R.; LaFerriere, Brian D.

2013-08-08

An increasing number of physics experiments require low background materials for their construction. The presence of Uranium and Thorium and their progeny in these materials present a variety of unwanted background sources for these experiments. The sensitivity of the experiments continues to drive the necessary levels of detection ever lower as well. This requirement for greater sensitivity has rendered direct radioassay impractical in many cases requiring large quantities of material, frequently many kilograms, and prolonged counting times, often months. Other assay techniques have been employed such as Neutron Activation Analysis but this requires access to expensive facilities and instrumentation andmore » can be further complicated and delayed by the formation of unwanted radionuclides. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is a useful tool and recent advancements have increased the sensitivity particularly in the elemental high mass range of U and Th. Unlike direct radioassay, ICP-MS is a destructive technique since it requires the sample to be in liquid form which is aspirated into a high temperature plasma. But it benefits in that it usually requires a very small sample, typically about a gram. Here we will discuss how a variety of low background materials such as copper, polymers, and fused silica are made amenable to ICP-MS assay and how the arduous task of maintaining low backgrounds of U and Th is achieved.« less

Connecting the Dots: Rediscovering Continuity

ERIC Educational Resources Information Center

Camenga, Kristin A.; Yates, Rebekah B. Johnson

2014-01-01

The topic of continuity is typically not introduced until calculus and then reexamined in real analysis. Recognizing the connections between secondary school mathematics and the advanced mathematics studied at the college level allows teachers to better identify mathematical concepts in student ideas, motivate students by piquing their curiosity,…

Evaluation of glucose response to 3 types of insulin using a continuous glucose monitoring system in healthy alpacas.

PubMed

Byers, S R; Beemer, O M; Lear, A S; Callan, R J

2014-01-01

Persistent hyperglycemia is common in alpacas and typically requires insulin administration for resolution; however, little is known about alpacas' response to different insulin formulations. To evaluate the effects of 3 insulin formulations on blood glucose concentrations and the use of a continuous glucose monitoring (CGM) system in alpacas. Six healthy alpacas. The CGM was installed in the left paralumbar fossa at the start of this crossover study and recorded data every 5 minutes. Regular insulin, NPH insulin, insulin glargine, and dextrose were administered to each alpaca over a 2-week period. Blood samples were collected for glucose testing at 0, 1, 2, 4, 6, 8, and 12 hours, and then every 6 hours after each administration of insulin or dextrose. Data were compared by using method comparison techniques, error grid plots, and ANOVA. Blood glucose concentrations decreased most rapidly after regular insulin administration when administered IV or SC as compared to the other formulations. The NPH insulin produced the longest suppression of blood glucose. The mean CGM interstitial compartment glucose concentrations were typically lower than the intravascular compartment glucose concentrations. The alpacas had no adverse reactions to the different insulin formulations. The NPH insulin might be more appropriate for long-term use in hyperglycemic alpacas because of its extended duration of action. A CGM is useful in monitoring glucose trends and reducing blood collection events, but it should not be the sole method for determining treatment protocols. Copyright © 2014 by the American College of Veterinary Internal Medicine.

Neural dysfunction in ADHD with Reading Disability during a word rhyming Continuous Performance Task.

PubMed

Mohl, B; Ofen, N; Jones, L L; Robin, A L; Rosenberg, D R; Diwadkar, V A; Casey, J E; Stanley, J A

2015-10-01

Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous, neurodevelopmental disorder which co-occurs often with Reading Disability (RD). ADHD with and without RD consistently have higher inattentive ratings compared with typically developing controls, with co-occurring ADHD and RD also demonstrating impaired phonological processing. Accordingly, inattention has been associated with greater phonological impairment, though the neural correlates of the association are poorly understood from a functional neuroimaging perspective. It was postulated that only the co-occurring subgroup would demonstrate hypoactivation of posterior, left hemispheric, reading-related areas and, to a lesser extent, alterations in right hemispheric, attention areas compared with controls. A novel word rhyming Continuous Performance Task assesses functional activation differences in phonology- and attention-related areas between three groups: ten boys with ADHD and RD, fourteen boys with ADHD without RD, and fourteen typically developing controls. Subjects respond to words that rhyme with a target word as mono- and disyllabic, English words are visually presented over 90s blocks. Behavioral performance was not different between groups. Some hypoactivation of left hemispheric, reading-related areas was apparent in ADHD and RD, but not ADHD without RD, compared with controls. Right hemispheric, attention areas showed alterations in both ADHD subgroups relative to controls; however, the differences for each subgroup were dissimilar. The dorsal decoding subnetwork may not be grossly compromised in ADHD with Reading Disability. The role of cognitive impairments, including the level of inattention, on phonology requires clarification from a neuroimaging perspective. Copyright © 2015 Elsevier Inc. All rights reserved.

Late Noachian Climate Of Mars: Constraints From Valley Network System Formation Times And The Intermittencies (Episodic/Periodic And Punctuated).

NASA Astrophysics Data System (ADS)

Head, James

2017-04-01

Formation of Late Noachian-Early Hesperian (LN-EH) valley network systems (VNS) signaled the presence of warm/wet conditions generating several hypotheses for climates permissive of these conditions. To constrain options for the ambient Noachian climate, we examine estimates for time required to carve channels/deltas and total duration implied by plausible intermittencies. Formation Times for VN, OBL, Deltas, Fans: A synthesis of required timescales show that even with the longest estimated continuous duration of VN formation/intermittencies, total time to carve the VN does not exceed 106 years, <˜0.25% of the total Noachian. Intermittency/episodicity assumptions are climate-model dependent (e.g., most workers use Earth-like fluvial activity and intermittency). Noachian-Early Hesperian Climate Models: 1) Warm and wet/semiarid/arid climate: Sustained background MAT >273 K, hydrological system vertically integrated, and rainfall occurs to recharge the aquifer. Two subtypes: a) "Rainfall/Fluvial Erosion-Dominated Warm and Wet Model": "Rainfall and surface runoff" persist throughout Noachian to explain crater degradation, and a LN-EH short rapidly ending terminal epoch. b) "Recharge Evaporation/Evaporite Dominated Warm and Wet Model": Sustained period of equatorial/mid-latitude precipitation and a vertically integrated hydrological system driven by evaporative upwelling and fluctuating shallow water table playa environments account for sulfate evaporate environments at Meridiani Planum. Sustained temperatures >273 K are required for extended periods (107-108 years). 2) Cold and icy climate: Sustained background temperatures extremely low (MAT ˜225 K), cryosphere is globally continuous, hydrological system is horizontally stratified, separating groundwater system from surface; no combination of spin-axis/orbital perturbations can raise MAT to 273 K. Adiabatic cooling effects transfer water to high altitudes, leading to "Late Noachian Icy Highlands Model". VNS cannot form in this nominal climate environment without special circumstances (e.g., impacts or volcanic eruptions elevate of temperatures by >˜50 K to induce melting and fluvial/lacustrine activity). 3) Cold and Icy climate warmed by greenhouse gases: The climate is sustained cold/icy model, but greenhouse gases of unspecified nature/amount/duration elevate MAT by several tens of Kelvins (say 25 K, to MAT 250 K), bringing annual temperature range into the realm where peak seasonal temperatures (PST) exceed 273 K. In this climate environment, analogous to the Antarctic Dry Valleys, seasonal summer temperatures above 273 K are sufficient to melt snow/ice and form fluvial and lacustrine features, but MAT is well below 273 K (253 K). Fluvial systems driven by episodic/periodic intermittency typically involve short intermittency time-scales (10-106 years) but require a warm climate (MAT >273 K) to be sustained for >0.4 x 109 years. Fluvial systems driven by punctuated intermittency typically involve short duration time-scales (10-105 years) but only require a warm climate (MAT >273 K) for the very short duration of the climatic impact of the punctuated event (102-105 years). We conclude that a cold and icy background climate with punctuated intermittency of warming and melting events is consistent with: 1) the estimated durations of continuous VN formation (<105 years) and 2) VN system estimated recurrence rates (106-107 years).

Space station needs, attributes and architectural options study. Volume 3: Requirements

NASA Technical Reports Server (NTRS)

1983-01-01

A typical system specification format is presented and requirements are compiled. A Program Specification Tree is shown showing a high inclination space station and a low inclination space station with their typical element breakdown, also represented along the top blocks are the interfaces with other systems. The specification format is directed at the Low Inclination space station.

Acute pavement burns: a unique subset of burn injuries: a five-year review of resource use and cost impact.

PubMed

Silver, Andrew G; Dunford, Gerrit M; Zamboni, William A; Baynosa, Richard C

2015-01-01

This study focuses on the hospital care of a rare subset of burn injuries caused by contact with environmentally heated pavement, to further understand the required use of resources. This article aims to show that pavement burns are typically more severe than their flame/scald counterparts. A retrospective review of patients admitted to the burn center with injuries suffered from contact with hot pavement was performed. Patients were stratified on the presence or absence of altered mental status (AMS) and additional inciting factors. A representative sample of similarly sized flame and scald wounds treated in the same time period was compiled for comparison. Those with pavement burns had a significantly greater requirement for operative intervention, repetitive debridements, overall cost/percent burned, and lengthier hospital stays than those with flame/scald burns. Pavement burn victims with AMS were significantly more likely to require an operation, a greater cost/percent burned, and longer hospital stays than those without AMS. Pavement burns are significantly worse than similarly sized scald/flame burns with regards to length of stay and total hospital costs, and the necessity of initial and repetitive operative intervention. These discrepancies are even greater in patients with AMS as a concomitant inciting factor. It is apparent that these wounds often continue to deepen during a patient's stay, likely because of continued pressure on the wounds while recumbent. As such, this article highly recommends pressure off-loading beds and more aggressive debridement in the treatment of these unique injuries.

Decision curve analysis: a novel method for evaluating prediction models.

PubMed

Vickers, Andrew J; Elkin, Elena B

2006-01-01

Diagnostic and prognostic models are typically evaluated with measures of accuracy that do not address clinical consequences. Decision-analytic techniques allow assessment of clinical outcomes but often require collection of additional information and may be cumbersome to apply to models that yield a continuous result. The authors sought a method for evaluating and comparing prediction models that incorporates clinical consequences,requires only the data set on which the models are tested,and can be applied to models that have either continuous or dichotomous results. The authors describe decision curve analysis, a simple, novel method of evaluating predictive models. They start by assuming that the threshold probability of a disease or event at which a patient would opt for treatment is informative of how the patient weighs the relative harms of a false-positive and a false-negative prediction. This theoretical relationship is then used to derive the net benefit of the model across different threshold probabilities. Plotting net benefit against threshold probability yields the "decision curve." The authors apply the method to models for the prediction of seminal vesicle invasion in prostate cancer patients. Decision curve analysis identified the range of threshold probabilities in which a model was of value, the magnitude of benefit, and which of several models was optimal. Decision curve analysis is a suitable method for evaluating alternative diagnostic and prognostic strategies that has advantages over other commonly used measures and techniques.

Impact of College-Administered Quality Practice Assessments: A Longitudinal Evaluation of Repeat Peer Assessments of Continuing Competence in Physiotherapists

PubMed Central

O'Donovan, Mary Jane; Campbell, Fiona

2015-01-01

ABSTRACT Purpose: The College of Physiotherapists of Ontario (CPO) developed its peer practice assessment (PA) process under statutory requirements for quality assurance. Each year, a small percentage of physiotherapists, most selected at random, undergo PA. To shed light on continuing competence, we report outcomes from physiotherapists who have had two PAs. Methods: Records were extracted for physiotherapists with two unrelated PAs. Demographic features, peer assessors' scores, and consequent outcome decisions were examined. Outcomes were examined cross-sectionally (vs. other PAs in the same time period) and longitudinally (within cohort). Results: Between 2004 and 2012, 117 Ontario physiotherapists underwent two unrelated PAs, typically 5–7 years apart. This cohort was representative of Ontario physiotherapists in terms of sex ratios, education, and years in practice. At the first PA (PA1), this cohort's outcomes were similar to those of other physiotherapists; at the second PA (PA2), they were better than others undergoing PA1 in the same period (p=0.02). The cohort's outcomes were better at PA2 than at PA1 (p<0.001). Conclusions: Physiotherapists are likely to meet professional standards in a repeat PA 5–7 years after an initial one. Additional research is required to identify risk factors for not meeting standards. The findings provide empirical evidence to guide ongoing development of the CPO's quality management program. PMID:25931670

Fast attainment of computer cursor control with noninvasively acquired brain signals

NASA Astrophysics Data System (ADS)

Bradberry, Trent J.; Gentili, Rodolphe J.; Contreras-Vidal, José L.

2011-06-01

Brain-computer interface (BCI) systems are allowing humans and non-human primates to drive prosthetic devices such as computer cursors and artificial arms with just their thoughts. Invasive BCI systems acquire neural signals with intracranial or subdural electrodes, while noninvasive BCI systems typically acquire neural signals with scalp electroencephalography (EEG). Some drawbacks of invasive BCI systems are the inherent risks of surgery and gradual degradation of signal integrity. A limitation of noninvasive BCI systems for two-dimensional control of a cursor, in particular those based on sensorimotor rhythms, is the lengthy training time required by users to achieve satisfactory performance. Here we describe a novel approach to continuously decoding imagined movements from EEG signals in a BCI experiment with reduced training time. We demonstrate that, using our noninvasive BCI system and observational learning, subjects were able to accomplish two-dimensional control of a cursor with performance levels comparable to those of invasive BCI systems. Compared to other studies of noninvasive BCI systems, training time was substantially reduced, requiring only a single session of decoder calibration (~20 min) and subject practice (~20 min). In addition, we used standardized low-resolution brain electromagnetic tomography to reveal that the neural sources that encoded observed cursor movement may implicate a human mirror neuron system. These findings offer the potential to continuously control complex devices such as robotic arms with one's mind without lengthy training or surgery.

Photo-conductive detection of continuous THz waves via manipulated ultrafast process in nanostructures

NASA Astrophysics Data System (ADS)

Moon, Kiwon; Lee, Eui Su; Lee, Il-Min; Park, Dong Woo; Park, Kyung Hyun

2018-01-01

Time-domain and frequency-domain terahertz (THz) spectroscopy systems often use materials fabricated with exotic and expensive methods that intentionally introduce defects to meet short carrier lifetime requirements. In this study, we demonstrate the development of a nano-photomixer that meets response speed requirements without using defect-incorporated, low-temperature-grown (LTG) semiconductors. Instead, we utilized a thin InGaAs layer grown on a semi-insulating InP substrate by metal-organic chemical vapor deposition (MOCVD) combined with nano-electrodes to manipulate local ultrafast photo-carrier dynamics via a carefully designed field-enhancement and plasmon effect. The developed nano-structured photomixer can detect continuous-wave THz radiation up to a frequency of 2 THz with a peak carrier collection efficiency of 5%, which is approximately 10 times better than the reference efficiency of 0.4%. The better efficiency results from the high carrier mobility of the MOCVD-grown InGaAs thin layer with the coincidence of near-field and plasmon-field distributions in the nano-structure. Our result not only provides a generally applicable methodology for manipulating ultrafast carrier dynamics by means of nano-photonic techniques to break the trade-off relation between the carrier lifetime and mobility in typical LTG semiconductors but also contributes to mass-producible photo-conductive THz detectors to facilitate the widespread application of THz technology.

Low power multi-camera system and algorithms for automated threat detection

NASA Astrophysics Data System (ADS)

Huber, David J.; Khosla, Deepak; Chen, Yang; Van Buer, Darrel J.; Martin, Kevin

2013-05-01

A key to any robust automated surveillance system is continuous, wide field-of-view sensor coverage and high accuracy target detection algorithms. Newer systems typically employ an array of multiple fixed cameras that provide individual data streams, each of which is managed by its own processor. This array can continuously capture the entire field of view, but collecting all the data and back-end detection algorithm consumes additional power and increases the size, weight, and power (SWaP) of the package. This is often unacceptable, as many potential surveillance applications have strict system SWaP requirements. This paper describes a wide field-of-view video system that employs multiple fixed cameras and exhibits low SWaP without compromising the target detection rate. We cycle through the sensors, fetch a fixed number of frames, and process them through a modified target detection algorithm. During this time, the other sensors remain powered-down, which reduces the required hardware and power consumption of the system. We show that the resulting gaps in coverage and irregular frame rate do not affect the detection accuracy of the underlying algorithms. This reduces the power of an N-camera system by up to approximately N-fold compared to the baseline normal operation. This work was applied to Phase 2 of DARPA Cognitive Technology Threat Warning System (CT2WS) program and used during field testing.

Hybrid estimation of complex systems.

PubMed

Hofbaur, Michael W; Williams, Brian C

2004-10-01

Modern automated systems evolve both continuously and discretely, and hence require estimation techniques that go well beyond the capability of a typical Kalman Filter. Multiple model (MM) estimation schemes track these system evolutions by applying a bank of filters, one for each discrete system mode. Modern systems, however, are often composed of many interconnected components that exhibit rich behaviors, due to complex, system-wide interactions. Modeling these systems leads to complex stochastic hybrid models that capture the large number of operational and failure modes. This large number of modes makes a typical MM estimation approach infeasible for online estimation. This paper analyzes the shortcomings of MM estimation, and then introduces an alternative hybrid estimation scheme that can efficiently estimate complex systems with large number of modes. It utilizes search techniques from the toolkit of model-based reasoning in order to focus the estimation on the set of most likely modes, without missing symptoms that might be hidden amongst the system noise. In addition, we present a novel approach to hybrid estimation in the presence of unknown behavioral modes. This leads to an overall hybrid estimation scheme for complex systems that robustly copes with unforeseen situations in a degraded, but fail-safe manner.

Discounting the future: influence of the economic model.

PubMed Central

West, R R

1996-01-01

OBJECTIVE: To consider the effect of the economic discount rate on health care policy and the rationale for discounting the collective future of society generally. DESIGN: A review of the concept of discounting the future vis à vis the present from the points of view of individuals (who pass on) and of societies (that continue) and reconsideration of the application of discounting to typical public health scenarios. SETTING: A public health service, within a basically stable society, which can reasonably anticipate a nearly certain future. RESULTS: Discounting necessarily overvalues the "here and now" compared with the future. While applications of discount rates, typical of those employed in health economic studies in recent years, may seem rational in health care programmes directed at middle aged employed people, they do not for the young and the elderly, important recipients of health care. The consequences of discounting do not accord with the aims and objectives of public health. CONCLUSIONS: The "time preferences" of transient individuals within a stable society do not provide a rational basis for time preference of a stable society collectively. Discounting inevitably encourages "short termism" and hence biases public policy decision making. The neoclassical theory that gave rise to the concept of discounting requires revision. PMID:8935452

Discounting the future: influence of the economic model.

PubMed

West, R R

1996-06-01

To consider the effect of the economic discount rate on health care policy and the rationale for discounting the collective future of society generally. A review of the concept of discounting the future vis à vis the present from the points of view of individuals (who pass on) and of societies (that continue) and reconsideration of the application of discounting to typical public health scenarios. A public health service, within a basically stable society, which can reasonably anticipate a nearly certain future. Discounting necessarily overvalues the "here and now" compared with the future. While applications of discount rates, typical of those employed in health economic studies in recent years, may seem rational in health care programmes directed at middle aged employed people, they do not for the young and the elderly, important recipients of health care. The consequences of discounting do not accord with the aims and objectives of public health. The "time preferences" of transient individuals within a stable society do not provide a rational basis for time preference of a stable society collectively. Discounting inevitably encourages "short termism" and hence biases public policy decision making. The neoclassical theory that gave rise to the concept of discounting requires revision.

A BALANCED TEAM WINS CHAMPIONSHIPS: 66 YEARS OF DATA FROM THE NATIONAL BASKETBALL ASSOCIATION AND THE NATIONAL FOOTBALL LEAGUE.

PubMed

Otten, Mark P; Miller, Travis J

2015-12-01

Explicitly monitoring one's own actions has been noted as detrimental to the performance of fine motor skills under duress. Offensive skills rather than defensive skills are typically studied in this context. Defensive techniques typically require skills such as footwork and continuous movement, as opposed to more precise, hand-eye coordinated action. Explicit monitoring theory may be less relevant for defensive skills than offensive skills when playing under pressure. Archival data (66 years) for teams and for individual players was compiled from the National Basketball Association (NBA) and the National Football League (NFL). For basketball (n=778) and football (n=515) teams, regular season offensive and defensive statistics similarly predicted success in the postseason, which was assumed to create more pressure. For individual basketball players (n=5,132), nine indices of offensive (FG, free throw and three-point shooting, offensive win shares, points, and assists) and defensive (defensive win shares, steals, and blocks) production were compared; among these, three-point shooting percentage was least correlated from season to postseason, suggesting it is especially variable under pressure. A balanced basketball or football team that focuses on both offense and defense may be most successful.

Fundamentals of Research Data and Variables: The Devil Is in the Details.

PubMed

Vetter, Thomas R

2017-10-01

Designing, conducting, analyzing, reporting, and interpreting the findings of a research study require an understanding of the types and characteristics of data and variables. Descriptive statistics are typically used simply to calculate, describe, and summarize the collected research data in a logical, meaningful, and efficient way. Inferential statistics allow researchers to make a valid estimate of the association between an intervention and the treatment effect in a specific population, based upon their randomly collected, representative sample data. Categorical data can be either dichotomous or polytomous. Dichotomous data have only 2 categories, and thus are considered binary. Polytomous data have more than 2 categories. Unlike dichotomous and polytomous data, ordinal data are rank ordered, typically based on a numerical scale that is comprised of a small set of discrete classes or integers. Continuous data are measured on a continuum and can have any numeric value over this continuous range. Continuous data can be meaningfully divided into smaller and smaller or finer and finer increments, depending upon the precision of the measurement instrument. Interval data are a form of continuous data in which equal intervals represent equal differences in the property being measured. Ratio data are another form of continuous data, which have the same properties as interval data, plus a true definition of an absolute zero point, and the ratios of the values on the measurement scale make sense. The normal (Gaussian) distribution ("bell-shaped curve") is of the most common statistical distributions. Many applied inferential statistical tests are predicated on the assumption that the analyzed data follow a normal distribution. The histogram and the Q-Q plot are 2 graphical methods to assess if a set of data have a normal distribution (display "normality"). The Shapiro-Wilk test and the Kolmogorov-Smirnov test are 2 well-known and historically widely applied quantitative methods to assess for data normality. Parametric statistical tests make certain assumptions about the characteristics and/or parameters of the underlying population distribution upon which the test is based, whereas nonparametric tests make fewer or less rigorous assumptions. If the normality test concludes that the study data deviate significantly from a Gaussian distribution, rather than applying a less robust nonparametric test, the problem can potentially be remedied by judiciously and openly: (1) performing a data transformation of all the data values; or (2) eliminating any obvious data outlier(s).

Continuous Performance Tasks: Not Just about Sustaining Attention

ERIC Educational Resources Information Center

Roebuck, Hettie; Freigang, Claudia; Barry, Johanna G.

2016-01-01

Purpose: Continuous performance tasks (CPTs) are used to measure individual differences in sustained attention. Many different stimuli have been used as response targets without consideration of their impact on task performance. Here, we compared CPT performance in typically developing adults and children to assess the role of stimulus processing…

Prostate Cancer Biorepository Network (PCBN)

DTIC Science & Technology

2017-10-01

historic data we typically expect 8 autopsies a year and we have performed 15 in the last year. All specimens have been processed and read by a...3 times as xenografts in animals with continuous growth. We are currently maintaining 42 lines and continue to passage tumors in animals to develop

Virtual Reference Service in Academic Libraries in West Africa

ERIC Educational Resources Information Center

Sekyere, Kwabena

2011-01-01

As technology continues to advance, libraries in Europe and America continue to improve upon their virtual reference services by employing new Web technologies and applying them to existing services. West African academic libraries have begun providing resources electronically to their users but still typically lag behind in the services they…

40 CFR 92.104 - Locomotive and engine testing; overview.

Code of Federal Regulations, 2011 CFR

2011-07-01

... restriction within 1 inch of water of the upper limit of a typical engine as installed with clean air filters...; overview. 92.104 Section 92.104 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92...

40 CFR 92.104 - Locomotive and engine testing; overview.

Code of Federal Regulations, 2010 CFR

2010-07-01

... restriction within 1 inch of water of the upper limit of a typical engine as installed with clean air filters...; overview. 92.104 Section 92.104 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92...

How Mathematics Propels the Development of Physical Knowledge

ERIC Educational Resources Information Center

Schwartz, Daniel L.; Martin, Taylor; Pfaffman, Jay

2005-01-01

Three studies examined whether mathematics can propel the development of physical understanding. In Experiment 1, 10-year-olds solved balance scale problems that used easy-to-count discrete quantities or hard-to-count continuous quantities. Discrete quantities led to age typical performances. Continuous quantities caused performances like those of…

Interactions of Task and Subject Variables among Continuous Performance Tests

ERIC Educational Resources Information Center

Denney, Colin B.; Rapport, Mark D.; Chung, Kyong-Mee

2005-01-01

Background: Contemporary models of working memory suggest that target paradigm (TP) and target density (TD) should interact as influences on error rates derived from continuous performance tests (CPTs). The present study evaluated this hypothesis empirically in a typically developing, ethnically diverse sample of children. The extent to which…

40 CFR Table 6 to Subpart Vvvv of... - Default Organic HAP Contents of Petroleum Solvent Groups

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants for Boat... content, percent by mass Typical organic HAP, percent by mass Aliphatic (Mineral Spirits 135, Mineral...

Beach Books: 2014-2016. What Do Colleges and Universities Want Students to Read outside Class?

ERIC Educational Resources Information Center

Randall, David

2016-01-01

Hundreds of American colleges and universities continue to assign a summer reading to entering freshmen--typically one book, which the students are asked to read outside their courses. Many institutions embed the common reading in a larger program of campus activities: typically, they invite the common reading author to help open the academic year…

From empirical data to time-inhomogeneous continuous Markov processes.

PubMed

Lencastre, Pedro; Raischel, Frank; Rogers, Tim; Lind, Pedro G

2016-03-01

We present an approach for testing for the existence of continuous generators of discrete stochastic transition matrices. Typically, existing methods to ascertain the existence of continuous Markov processes are based on the assumption that only time-homogeneous generators exist. Here a systematic extension to time inhomogeneity is presented, based on new mathematical propositions incorporating necessary and sufficient conditions, which are then implemented computationally and applied to numerical data. A discussion concerning the bridging between rigorous mathematical results on the existence of generators to its computational implementation is presented. Our detection algorithm shows to be effective in more than 60% of tested matrices, typically 80% to 90%, and for those an estimate of the (nonhomogeneous) generator matrix follows. We also solve the embedding problem analytically for the particular case of three-dimensional circulant matrices. Finally, a discussion of possible applications of our framework to problems in different fields is briefly addressed.

Risk determinants of small and medium-sized manufacturing enterprises (SMEs) - an exploratory study in New Zealand

NASA Astrophysics Data System (ADS)

Islam, Ariful; Tedford, Des

2012-08-01

The smooth running of small and medium-sized manufacturing enterprises (SMEs) presents a significant challenge irrespective of the technological and human resources they may have at their disposal. SMEs continuously encounter daily internal and external undesirable events and unwanted setbacks to their operations that detract from their business performance. These are referred to as `disturbances' in our research study. Among the disturbances, some are likely to create risks to the enterprises in terms of loss of production, manufacturing capability, human resource, market share, and, of course, economic losses. These are finally referred to as `risk determinant' on the basis of their correlation with some risk indicators, which are linked to operational, occupational, and economic risks. To deal with these risk determinants effectively, SMEs need a systematic method of approach to identify and treat their potential effects along with an appropriate set of tools. However, initially, a strategic approach is required to identify typical risk determinants and their linkage with potential business risks. In this connection, we conducted this study to explore the answer to the research question: what are the typical risk determinants encountered by SMEs? We carried out an empirical investigation with a multi-method research approach (a combination of a questionnaire-based mail survey involving 212 SMEs and five in-depth case studies) in New Zealand. This paper presents a set of typical internal and external risk determinants, which need special attention to be dealt with to minimize operational risks of an SME.

Subcutaneous insulin therapy - end of the road after 80 years?

PubMed

Leifke, E; Strack, T R

2014-02-01

Subcutaneous (SC) insulin therapy has been a mainstay of pharmacological diabetes management from the moment insulin was successfully developed as treatment. Insulin formulations have become more refined and less allergenic over time, and ancillary technologies such as injection devices and glucose measurement tools have evolved to the extent of permitting closed-loop therapy. However, investigations have continued exploring alternative routes of administration with the ultimate goal of implantable islet replacements, whether cell- or "silicon"-based. Progress on these lines of research, however, has been slow to present patients with viable options: alternative delivery routes have failed to deliver insulin reliably and with commercially viable efficiency, while beta cell transplantation continues to struggle with tissue availability and in vivo viability. In the meantime, SC insulin formulations have advanced for rapid- and long-acting formulations, to better meet typical insulin requirements across the day. Thus, SC insulin will likely remain a key technology for the foreseeable future in order to address the needs of an ever larger number of insulin-dependent patients with diabetes. Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.

Long-term reproducibility of relative sensitivity factors obtained with CAMECA Wf

NASA Astrophysics Data System (ADS)

Gui, D.; Xing, Z. X.; Huang, Y. H.; Mo, Z. Q.; Hua, Y. N.; Zhao, S. P.; Cha, L. Z.

2008-12-01

As the wafer size continues to increase and the feature size of the integrated circuits (IC) continues to shrink, process control of IC manufacturing becomes ever more important to reduce the cost of failures caused by the drift of processes or equipments. Characterization tools with high precision and reproducibility are required to capture any abnormality of the process. Although Secondary ion mass spectrometry (SIMS) has been widely used in dopant profile control, it was reported that magnetic sector SIMS, compared to quadrupole SIMS, has lower short-term repeatability and long-term reproducibility due to the high extraction field applied between sample and extraction lens. In this paper, we demonstrate that CAMECA Wf can deliver high long-term reproducibility because of its high-level automation and improved design of immersion lens. The relative standard deviation (R.S.D.) of the relative sensitivity factors (RSF) of three typical elements, i.e., boron (B), phosphorous (P) and nitrogen (N), over 3 years are 3.7%, 5.5% and 4.1%, respectively. The high reproducibility results have a practical implication that deviation can be estimated without testing the standards.

End-point detection in potentiometric titration by continuous wavelet transform.

PubMed

Jakubowska, Małgorzata; Baś, Bogusław; Kubiak, Władysław W

2009-10-15

The aim of this work was construction of the new wavelet function and verification that a continuous wavelet transform with a specially defined dedicated mother wavelet is a useful tool for precise detection of end-point in a potentiometric titration. The proposed algorithm does not require any initial information about the nature or the type of analyte and/or the shape of the titration curve. The signal imperfection, as well as random noise or spikes has no influence on the operation of the procedure. The optimization of the new algorithm was done using simulated curves and next experimental data were considered. In the case of well-shaped and noise-free titration data, the proposed method gives the same accuracy and precision as commonly used algorithms. But, in the case of noisy or badly shaped curves, the presented approach works good (relative error mainly below 2% and coefficients of variability below 5%) while traditional procedures fail. Therefore, the proposed algorithm may be useful in interpretation of the experimental data and also in automation of the typical titration analysis, specially in the case when random noise interfere with analytical signal.

Planning for and surviving a BCM audit.

PubMed

Freestone, Mandy; Lee, Michael

2008-01-01

Business continuity management (BCM) is moving progressively higher up the agendas of boardroom executives due to growing regulator, insurer and investor interest in risk management and BCM activity. With increasing pressure across all sectors, BCM has become an integral part of any effective corporate governance framework. Boardroom executives and senior management are thus now expected to provide an appropriate level of business continuity preparedness to better protect shareholder, investor and other stakeholder interests. The purpose of this paper is to build a link across the 'chasm' that separates the auditee from the auditor. The paper attempts to illuminate understanding about the process undertaken by an auditor when reviewing the BCM process. It details the steps the BCM auditor typically undertakes, and provides practical guidance as to the types of documentation and other supporting evidence required during the process. Additionally, the paper attempts to dispel commonly-held misconceptions about the BCM audit process. Executives, senior management and BCM practitioners will all benefit from the practical guidance offered in this paper, to assist in planning for and surviving a BCM audit.

Continuous profiles of microstructure, stable water isotopes and impurity content of the 2m snow pack from three polar drill sites

NASA Astrophysics Data System (ADS)

Freitag, Johannes; Schaller, Christoph; Kipfstuhl, Sepp; Hörhold, Maria; Schaidt, Maximilian; Sander, Merle; Moser, Dorothea

2017-04-01

Interpreting polar ice as climate archive requires profound knowledge about the formation of climate-proxies within the upper snow column. In order to investigate different impact factors on signal formation we performed a multiproxy- approach for 2m deep snow profiles by continuously measuring the 3D-microstructure using core-scale X-CT and the isotopic composition and impurity load in discrete samples of 1.1cm spatial resolution. The study includes profiles from a low-accumulation site on the East Antarctic plateau (Kohnen Station, DML), a typical medium-accumulation site on the North-East-Greenland ice sheet (EGRIP drilling camp) and a high-accumulation site on the Renland ice cap (East-coast of Greenland, RECAP drilling camp). Major observations are the tooth-shaped imprint of structural anisotropy and sulfate concentrations at the low accumulation site, the clear isotopic inter-annual variations that are in line with distinct impurity peaks at the high-accumulation site and the unexpected missing footprint of ice crusts and refrozen melt layers within the impurity- and isotope records for all sites.

Continental-scale water fluxes from continuous GPS observations of Earth surface loading

NASA Astrophysics Data System (ADS)

Borsa, A. A.; Agnew, D. C.; Cayan, D. R.

2015-12-01

After more than a decade of observing annual oscillations of Earth's surface from seasonal snow and water loading, continuous GPS is now being used to model time-varying terrestrial water fluxes on the local and regional scale. Although the largest signal is typically due to the seasonal hydrological cycle, GPS can also measure subtle surface deformation caused by sustained wet and dry periods, and to estimate the spatial distribution of the underlying terrestrial water storage changes. The next frontier is expanding this analysis to the continental scale and paving the way for incorporating GPS models into the National Climate Assessment and into the observational infrastructure for national water resource management. This will require reconciling GPS observations with predictions from hydrological models and with remote sensing observations from a suite of satellite instruments (e.g. GRACE, SMAP, SWOT). The elastic Earth response which transforms surface loads into vertical and horizontal displacements is also responsible for the contamination of loading observations by tectonic and anthropogenic transients, and we discuss these and other challenges to this new application of GPS.

Isothermal Time-Temperature-Precipitation Diagram for an Aluminum Alloy 6005A by In Situ DSC Experiments

PubMed Central

Milkereit, Benjamin; Giersberg, Lydia; Kessler, Olaf; Schick, Christoph

2014-01-01

Time-temperature-precipitation (TTP) diagrams deliver important material data, such as temperature and time ranges critical for precipitation during the quenching step of the age hardening procedure. Although the quenching step is continuous, isothermal TTP diagrams are often applied. Together with a so-called Quench Factor Analysis, they can be used to describe very different cooling paths. Typically, these diagrams are constructed based on mechanical properties or microstructures after an interrupted quenching, i.e., ex situ analyses. In recent years, an in situ calorimetric method to record continuous cooling precipitation diagrams of aluminum alloys has been developed to the application level by our group. This method has now been transferred to isothermal experiments, in which the whole heat treatment cycle was performed in a differential scanning calorimeter. The Al-Mg-Si-wrought alloy 6005A was investigated. Solution annealing at 540 °C and overcritical quenching to several temperatures between 450 °C and 250 °C were followed by isothermal soaking. Based on the heat flow curves during isothermal soaking, TTP diagrams were determined. An appropriate evaluation method has been developed. It was found that three different precipitation reactions in characteristic temperature intervals exist. Some of the low temperature reactions are not accessible in continuous cooling experiments and require isothermal studies. PMID:28788587

Precision ephemerides for gravitational-wave searches - III. Revised system parameters of Sco X-1

NASA Astrophysics Data System (ADS)

Wang, L.; Steeghs, D.; Galloway, D. K.; Marsh, T.; Casares, J.

2018-06-01

Neutron stars in low-mass X-ray binaries are considered promising candidate sources of continuous gravitational-waves. These neutron stars are typically rotating many hundreds of times a second. The process of accretion can potentially generate and support non-axisymmetric distortions to the compact object, resulting in persistent emission of gravitational-waves. We present a study of existing optical spectroscopic data for Sco X-1, a prime target for continuous gravitational-wave searches, with the aim of providing revised constraints on key orbital parameters required for a directed search with advanced-LIGO data. From a circular orbit fit to an improved radial velocity curve of the Bowen emission components, we derived an updated orbital period and ephemeris. Centre of symmetry measurements from the Bowen Doppler tomogram yield a centre of the disc component of 90 km s-1, which we interpret as a revised upper limit to the projected orbital velocity of the NS K1. By implementing Monte Carlo binary parameter calculations, and imposing new limits on K1 and the rotational broadening, we obtained a complete set of dynamical system parameter constraints including a new range for K1 of 40-90 km s-1. Finally, we discussed the implications of the updated orbital parameters for future continuous-waves searches.

Stabilization of Softwood-Derived Pyrolysis Oils for Continuous Bio-oil Hydroprocessing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olarte, Mariefel V.; Zacher, Alan H.; Padmaperuma, Asanga B.

The use of fast pyrolysis as a potential renewable liquid transportation fuel alternative to crude oil depends on successful catalytic upgrading to produce a refinery-ready product with oxygen content and qualities (i.e. specific functional group or compound content) that is compatible with the product’s proposed insertion point. Catalytic upgrading of bio-oil requires high temperature and pressure, while similar to crude oil hydrotreating, is not as straightforward for the thermally unstable pyrolysis oil. For years, a two-temperature zone, downflow trickle bed reactor was the state-of-the art for continuous operation. However, pressure excursion due to plug formation still occurred, typically at themore » high temperature transition zone, leading to a process shutdown within 140 h. Recently, a bio-oil pre-treatment process, together with a robust commercial catalyst, was found to be enabling the continuous operation of the two-zone hydroprocessing system. Here, we report the results on pre-treating bio-oil at 413 K and 8.4 MPa of flowing H2 (500 L H2/L bio-oil, 0.5 L bio-oil/L catalyst bed) and the attempts to characterize this oil product to understand the chemistry which enabled the long-term processing of bio-oil.« less

Isothermal Time-Temperature-Precipitation Diagram for an Aluminum Alloy 6005A by In Situ DSC Experiments.

PubMed

Milkereit, Benjamin; Giersberg, Lydia; Kessler, Olaf; Schick, Christoph

2014-03-28

Time-temperature-precipitation (TTP) diagrams deliver important material data, such as temperature and time ranges critical for precipitation during the quenching step of the age hardening procedure. Although the quenching step is continuous, isothermal TTP diagrams are often applied. Together with a so-called Quench Factor Analysis, they can be used to describe very different cooling paths. Typically, these diagrams are constructed based on mechanical properties or microstructures after an interrupted quenching, i.e ., ex situ analyses. In recent years, an in situ calorimetric method to record continuous cooling precipitation diagrams of aluminum alloys has been developed to the application level by our group. This method has now been transferred to isothermal experiments, in which the whole heat treatment cycle was performed in a differential scanning calorimeter. The Al-Mg-Si-wrought alloy 6005A was investigated. Solution annealing at 540 °C and overcritical quenching to several temperatures between 450 °C and 250 °C were followed by isothermal soaking. Based on the heat flow curves during isothermal soaking, TTP diagrams were determined. An appropriate evaluation method has been developed. It was found that three different precipitation reactions in characteristic temperature intervals exist. Some of the low temperature reactions are not accessible in continuous cooling experiments and require isothermal studies.

Shuttle propellant loading instrumenation development

NASA Technical Reports Server (NTRS)

Hamlet, J.

1975-01-01

A continuous capacitance sensor was developed and an analog signal conditioner was evaluated to demonstrate the acceptability of these items for use in the space shuttle propellant loading system. An existing basic sensor concept was redesigned to provide capability for cryogenic operation, to improve performance, and to minimize production costs. Sensor development verification consisted of evaluation of sensor linearity, cryogenic performance, and stability during vibration. The signal conditioner evaluation consisted mainly of establishing the effects of the variations in temperature and cable parameters and evaluating the stability. A sensor linearity of 0.04 in. was achieved over most of the sensor length. The sensor instability caused by vibration was 0.04 percent. The cryogenic performance data show a maximum instability of 0.19 percent at liquid hydrogen temperature; a theoretical calibration can be computed a within 1 percent. The signal conditioner evaluation showed that, with temperature compensation, all error sources typically contribute much less than 1 percent. An estimate of the accuracy achievable with the sensor and signal conditioner shows an rss estimate of 0.75 in. for liquid oxygen and 1.02 in. for liquid hydrogen. These are approximately four times better than the shuttle requirements. Comparison of continuous sensor and discrete sensor performance show the continuous sensor to be significantly better when there is surface activity due to sloshing, boiling, or other disturbances.

Anti-backlash drive systems for multi-degree freedom devices

DOEpatents

Lungwen Tsai; Sunlai Chang.

1993-09-14

A new and innovative concept is described for the control of backlash in gear-coupled transmission mechanisms. The concept utilizes redundant unidirectional drives to assure positive coupling of gear meshes at all times. Based on this concept, a methodology for the enumeration of admissible redundant-drive backlash-free robotic mechanisms has been established. Some typical two- and three-DOF mechanisms are disclosed. Furthermore, actuator torques have been derived as functions of either joint torques or end-effector dynamic performance requirements. A redundantly driven gear coupled transmission mechanism manipulator has a fail-safe advantage in that, except of the loss of backlash control, it can continue to function when one of its actuators fails. A two-DOF backlash-free arm has been reduced to practice to demonstrate the principle. 20 figures.

Using phase locking for improving frequency stability and tunability of THz-band gyrotrons

NASA Astrophysics Data System (ADS)

Adilova, Asel B.; Gerasimova, Svetlana A.; Melnikova, Maria M.; Tyshkun, Alexandra V.; Rozhnev, Andrey G.; Ryskin, Nikita M.

2018-04-01

Medium-power (10-100 W) THz-band gyrotrons operating in a continuous-wave (CW) mode are of great importance for many applications such as NMR spectroscopy with dynamic nuclear polarization (DNP/NMR), plasma diagnostics, nondestructive inspection, stand-off detection of radioactive materials, biomedical applications, etc. For all these applications, high frequency stability and tunability within 1-2 GHz frequency range is typically required. Apart from different existing techniques for frequency stabilization, phase locking has recently attracted strong interest. In this paper, we present the results of theoretical analysis and numerical simulation for several phase locking techniques: (a) phase locking by injection of the external driving signal; (b) mutual phase locking of two coupled gyrotrons; and (c) selfinjection locking by a wave reflected from the remote load.

Gene delivery by microfluidic flow-through electroporation based on constant DC and AC field.

PubMed

Geng, Tao; Zhan, Yihong; Lu, Chang

2012-01-01

Electroporation is one of the most widely used physical methods to deliver exogenous nucleic acids into cells with high efficiency and low toxicity. Conventional electroporation systems typically require expensive pulse generators to provide short electrical pulses at high voltage. In this work, we demonstrate a flow-through electroporation method for continuous transfection of cells based on disposable chips, a syringe pump, and a low-cost power supply that provides a constant voltage. We successfully transfect cells using either DC or AC voltage with high flow rates (ranging from 40 µl/min to 20 ml/min) and high efficiency (up to 75%). We also enable the entire cell membrane to be uniformly permeabilized and dramatically improve gene delivery by inducing complex migrations of cells during the flow.

Sickle Cell Crisis Complicated by Synthetic Cannabinoid Abuse: A Case Report.

PubMed

Zheng, Crystal Y; Minniti, Caterina P; Chaitowitz, Mark H

2016-06-01

We describe a case of delirium occurring in a hospitalized sickle cell patient. Following admission for a typical pain crisis, the patient continued to report unrelieved pain with marked agitation for several days, despite escalating doses of opioid analgesia, and ultimately required intubation following development of acute chest syndrome (ACS). After some delay, it was discovered that he had been using a synthetic cannabinoid (K2) which may have precipitated his pain crisis and, with hindsight, explained his prolonged period of delirium. Delayed recognition was due to multiple factors, notably the absence of an index of suspicion for this novel drug, the presence of alternate explanations for the patient's altered mental status, and the fact that reliable laboratory screening for synthetic cannabinoids is currently not widely available.

Mars north polar deposits: stratigraphy, age, and geodynamical response

USGS Publications Warehouse

Phillips, R.J.; Zuber, M.T.; Smrekar, S.E.; Mellon, M.T.; Head, J.W.; Tanaka, K.L.; Putzig, N.E.; Milkovich, S.M.; Campbell, B.A.; Plaut, J.J.; Safaeinili, A.; Seu, R.; Biccari, D.; Carter, L.M.; Picardi, G.; Orosei, R.; Surdas, Mohit P.; Heggy, E.; Zurek, R.W.; Egan, A.F.; Giacomoni, E.; Russo, F.; Cutigni, M.; Pettinelli, E.; Holt, J.W.; Leuschen, C.J.; Marinangeli, L.

2008-01-01

The Shallow Radar (SHARAD) on the Mars Reconnaissance Orbiter has imaged the internal stratigraphy of the north polar layered deposits of Mars. Radar reflections within the deposits reveal a laterally continuous deposition of layers, which typically consist of four packets of finely spaced reflectors separated by homogeneous interpacket regions of nearly pure ice. The packet/interpacket structure can be explained by approximately million-year periodicities in Mars' obliquity or orbital eccentricity. The observed ???100-meter maximum deflection of the underlying substrate in response to the ice load implies that the present-day thickness of an equilibrium elastic lithosphere is greater than 300 kilometers. Alternatively, the response to the load may be in a transient state controlled by mantle viscosity. Both scenarios probably require that Mars has a subchondritic abundance of heat-producing elements.

FEM analysis of an single stator dual PM rotors axial synchronous machine

NASA Astrophysics Data System (ADS)

Tutelea, L. N.; Deaconu, S. I.; Popa, G. N.

2017-01-01

The actual e - continuously variable transmission (e-CVT) solution for the parallel Hybrid Electric Vehicle (HEV) requires two electric machines, two inverters, and a planetary gear. A distinct electric generator and a propulsion electric motor, both with full power converters, are typical for a series HEV. In an effort to simplify the planetary-geared e-CVT for the parallel HEV or the series HEV we hereby propose to replace the basically two electric machines and their two power converters by a single, axial-air-gap, electric machine central stator, fed from a single PWM converter with dual frequency voltage output and two independent PM rotors. The proposed topologies, the magneto-motive force analysis and quasi 3D-FEM analysis are the core of the paper.

Collegial Activity Learning between Heterogeneous Sensors.

PubMed

Feuz, Kyle D; Cook, Diane J

2017-11-01

Activity recognition algorithms have matured and become more ubiquitous in recent years. However, these algorithms are typically customized for a particular sensor platform. In this paper we introduce PECO, a Personalized activity ECOsystem, that transfers learned activity information seamlessly between sensor platforms in real time so that any available sensor can continue to track activities without requiring its own extensive labeled training data. We introduce a multi-view transfer learning algorithm that facilitates this information handoff between sensor platforms and provide theoretical performance bounds for the algorithm. In addition, we empirically evaluate PECO using datasets that utilize heterogeneous sensor platforms to perform activity recognition. These results indicate that not only can activity recognition algorithms transfer important information to new sensor platforms, but any number of platforms can work together as colleagues to boost performance.

Effect of growth solution, membrane size and array connection on microbial fuel cell power supply for medical devices.

PubMed

Roxby, Daniel N; Nham Tran; Pak-Lam Yu; Nguyen, Hung T

2016-08-01

Implanted biomedical devices typically last a number of years before their batteries are depleted and a surgery is required to replace them. A Microbial Fuel Cell (MFC) is a device which by using bacteria, directly breaks down sugars to generate electricity. Conceptually there is potential to continually power implanted medical devices for the lifetime of a patient. To investigate the practical potential of this technology, H-Cell Dual Chamber MFCs were evaluated with two different growth solutions and measurements recorded for maximum power output both of individual MFCs and connected MFCs. Using Luria-Bertani media and connecting MFCs in a hybrid series and parallel arrangement with larger membrane sizes showed the highest power output and the greatest potential for replacing implanted batteries.

Mars north polar deposits: stratigraphy, age, and geodynamical response.

PubMed

Phillips, Roger J; Zuber, Maria T; Smrekar, Suzanne E; Mellon, Michael T; Head, James W; Tanaka, Kenneth L; Putzig, Nathaniel E; Milkovich, Sarah M; Campbell, Bruce A; Plaut, Jeffrey J; Safaeinili, Ali; Seu, Roberto; Biccari, Daniela; Carter, Lynn M; Picardi, Giovanni; Orosei, Roberto; Mohit, P Surdas; Heggy, Essam; Zurek, Richard W; Egan, Anthony F; Giacomoni, Emanuele; Russo, Federica; Cutigni, Marco; Pettinelli, Elena; Holt, John W; Leuschen, Carl J; Marinangeli, Lucia

2008-05-30

The Shallow Radar (SHARAD) on the Mars Reconnaissance Orbiter has imaged the internal stratigraphy of the north polar layered deposits of Mars. Radar reflections within the deposits reveal a laterally continuous deposition of layers, which typically consist of four packets of finely spaced reflectors separated by homogeneous interpacket regions of nearly pure ice. The packet/interpacket structure can be explained by approximately million-year periodicities in Mars' obliquity or orbital eccentricity. The observed approximately 100-meter maximum deflection of the underlying substrate in response to the ice load implies that the present-day thickness of an equilibrium elastic lithosphere is greater than 300 kilometers. Alternatively, the response to the load may be in a transient state controlled by mantle viscosity. Both scenarios probably require that Mars has a subchondritic abundance of heat-producing elements.

Continuing life test of a xenon hollow cathode for a space plasma contactor

NASA Technical Reports Server (NTRS)

Sarver-Verhey, Timothy R.

1994-01-01

Implementation of a hollow cathode plasma contactor for charge control on the Space Station has required validation of long-life hollow cathodes. A test series of hollow cathodes and hollow cathode plasma contactors was initiated as part of the plasma contactor development program. An on-going wear-test of a hollow cathode has demonstrated cathode operation in excess of 10,000 hours with small changes in operating parameters. The discharge has experienced 10 shutdowns during the test, all of which were due to test facility failures or expellant replenishment. In all cases, the cathode was re-ignited at approximately 42 volts and resumed typical operation. This test represents the longest demonstrated stable operation of a high current (greater than 1 A) xenon hollow cathode reported to date.

[Comparison of railway employees and college students as evaluator of vibration discomfort].

PubMed

Suzuki, Hiroaki

2002-06-01

Typically, vibration discomfort of railway cars was studied with railway employees as evaluator, because of their availability and interest, as well as various study requirements. However, it has not been shown that employees are appropriate for the task. In this study, railway employees were compared with college students in order to find how their ratings compared with those by ordinary passengers. An experiment was conducted in a running train, and 41 persons participated; about a half were railway employees and the other college students who were invited as non-specialists. Their task was to rate vibration discomfort on a scale of 1 to 4, continuously at an interval of 5 seconds. Results indicated that employee ratings showed smaller individual differences and in general were more cautious than the student ratings.

Final Report: Laser-Based Optical Trap for Remote Sampling of Interplanetary and Atmospheric Particulate Matter

NASA Technical Reports Server (NTRS)

Stysley, Paul

2016-01-01

Applicability to Early Stage Innovation NIAC Cutting edge and innovative technologies are needed to achieve the demanding requirements for NASA origin missions that require sample collection as laid out in the NRC Decadal Survey. This proposal focused on fully understanding the state of remote laser optical trapping techniques for capturing particles and returning them to a target site. In future missions, a laser-based optical trapping system could be deployed on a lander that would then target particles in the lower atmosphere and deliver them to the main instrument for analysis, providing remote access to otherwise inaccessible samples. Alternatively, for a planetary mission the laser could combine ablation and trapping capabilities on targets typically too far away or too hard for traditional drilling sampling systems. For an interstellar mission, a remote laser system could gather particles continuously at a safe distance; this would avoid the necessity of having a spacecraft fly through a target cloud such as a comet tail. If properly designed and implemented, a laser-based optical trapping system could fundamentally change the way scientists designand implement NASA missions that require mass spectroscopy and particle collection.

Composite Overwrapped Pressure Vessels, A Primer

NASA Technical Reports Server (NTRS)

McLaughlan, Pat B.; Forth, Scott C.; Grimes-Ledesma, Lorie R.

2011-01-01

Due to the extensive amount of detailed information that has been published on composite overwrapped pressure vessels (COPVs), this document has been written to serve as a primer for those who desire an elementary knowledge of COPVs and the factors affecting composite safety. In this application, the word "composite" simply refers to a matrix of continuous fibers contained within a resin and wrapped over a pressure barrier to form a vessel for gas or liquid containment. COPVs are currently used at NASA to contain high pressure fluids in propulsion, science experiments, and life support applications. They have a significant weight advantage over all metal vessels but require unique design, manufacturing, and test requirements. COPVs also involve a much more complex mechanical understanding due to the interplay between the composite overwrap and the inner liner. A metallic liner is typically used in a COPV as a fluid permeation barrier. The liner design concepts and requirements have been borrowed from all-metal vessels. However, application of metallic vessel design standards to a very thin liner is not straightforward. Different failure modes exist for COPVs than for all-metal vessels, and understanding of these failure modes is at a much more rudimentary level than for metal vessels.

Converging the capabilities of EAP artificial muscles and the requirements of bio-inspired robotics

NASA Astrophysics Data System (ADS)

Hanson, David F.; White, Victor

2004-07-01

The characteristics of Electro-actuated polymers (EAP) are typically considered inadequate for applications in robotics. But in recent years, there has been both dramatic increases in EAP technological capbilities and reductions in power requirements for actuating bio-inspired robotics. As the two trends continue to converge, one may anticipate that dramatic breakthroughs in biologically inspired robotic actuation will result due to the marraige of these technologies. This talk will provide a snapshot of how EAP actuator scientists and roboticists may work together on a common platform to accelerate the growth of both technologies. To demonstrate this concept of a platform to accelerate this convergence, the authors will discuss their work in the niche application of robotic facial expression. In particular, expressive robots appear to be within the range of EAP actuation, thanks to their low force requirements. Several robots will be shown that demonstrate realistic expressions with dramatically decreased force requirements. Also, detailed descriptions will be given of the engineering innovations that have enabled these robotics advancements-most notably, Structured-Porosity Elastomer Materials (SPEMs). SPEM manufacturing techniques create delicate cell-structures in a variety of elastomers that maintain the high elongation characteristics of the mother material, but because of the porisity, behave as sponge-materials, thus lower the force required to emulate facial expressions to levels output by several extant EAP actuators.

Continuing education requirements among State Occupational Therapy Regulatory Boards in the United States of America.

PubMed

Hall, Savannah R; Crifasi, Kristen A; Marinelli, Christina M; Yuen, Hon K

2016-01-01

The purpose of this study is to compare and contrast the contents of each state's occupational therapy (OT) regulatory board requirements regarding licensees' acquisition of continuing education units in the United States of America. Data related to continuing education requirements from each OT regulatory board of all 50 states and the District of Columbia in the United States were reviewed and categorized by two reviewers. Analysis was conducted based on the categorization of the continuing education requirements and activities required, allowed, and not allowed/not mentioned for continuing education units. Findings revealed non-uniformity and inconsistency of continuing education requirements for licensure renewal between OT regulatory boards and was coupled with lack of specific criteria for various continuing education activities. Continuing education requirements were not tailored to meet the needs of individual licensee's current and anticipated professional role and job responsibilities, with a negative bias towards presentation and publication allowed for continuing education units. Few boards mandated continuing education topics on ethics related to OT practice within each renewal cycle. OT regulatory boards should move towards unifying the reporting format of continuing education requirements across all states to reduce ambiguity and to ensure licensees are equipped to provide ethical and competent practice. Efforts could be made to enact continuing education requirements specific to the primary role of a particular licensee. Finally, assigning the amount of continuing education credits to be awarded for different activities should be based on research evidence rather than arbitrary determination.

Bilateral blindness secondary to optic nerve ischemia from severe amlodipine overdose: a case report.

PubMed

Kao, Raymond; Landry, Yves; Chick, Genevieve; Leung, Andrew

2017-08-03

Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of consciousness. We describe a case of a calcium channel blocker overdose that led to bilateral cortical blindness, a presentation that has not previously been reported. A 49-year-old white woman with known bilateral early optic atrophy presented to our hospital with hypotension and obtundation following a known ingestion of 150 mg of amlodipine. She was transferred to our intensive care unit where she was intubated, mechanically ventilated, and required maximal vasopressor support (norepinephrine 40 mcg/minute, epinephrine 40 mcg/minute, and vasopressin 2.4 units/hour) along with intravenously administered crystalloid boluses. Despite these measures, she continued to deteriorate with persistent hypotension and tachycardia, as well as anuria. Intralipid emulsion therapy was subsequently administered to which no initial response was observed. A chest X-ray revealed diffuse pulmonary edema; intravenous diuresis as well as continuous renal replacement therapy was initiated. Following the initiation of continuous renal replacement therapy, her oxygen requirements as well as urine output began to improve, and 3 days later she was liberated from mechanical ventilation. Following extubation, she complained of new onset visual impairment, specifically seeing only red-green colors, but no objects. An ophthalmologic examination revealed that this was due to bilateral optic atrophy from prolonged hypotension during the first 24 hours after the overdose. Persistent hypotension in the setting of a calcium channel blocker overdose can lead to worsening optic atrophy resulting in bilateral cortical blindness.

A Reconfigurable Real-Time Compressive-Sampling Camera for Biological Applications

PubMed Central

Fu, Bo; Pitter, Mark C.; Russell, Noah A.

2011-01-01

Many applications in biology, such as long-term functional imaging of neural and cardiac systems, require continuous high-speed imaging. This is typically not possible, however, using commercially available systems. The frame rate and the recording time of high-speed cameras are limited by the digitization rate and the capacity of on-camera memory. Further restrictions are often imposed by the limited bandwidth of the data link to the host computer. Even if the system bandwidth is not a limiting factor, continuous high-speed acquisition results in very large volumes of data that are difficult to handle, particularly when real-time analysis is required. In response to this issue many cameras allow a predetermined, rectangular region of interest (ROI) to be sampled, however this approach lacks flexibility and is blind to the image region outside of the ROI. We have addressed this problem by building a camera system using a randomly-addressable CMOS sensor. The camera has a low bandwidth, but is able to capture continuous high-speed images of an arbitrarily defined ROI, using most of the available bandwidth, while simultaneously acquiring low-speed, full frame images using the remaining bandwidth. In addition, the camera is able to use the full-frame information to recalculate the positions of targets and update the high-speed ROIs without interrupting acquisition. In this way the camera is capable of imaging moving targets at high-speed while simultaneously imaging the whole frame at a lower speed. We have used this camera system to monitor the heartbeat and blood cell flow of a water flea (Daphnia) at frame rates in excess of 1500 fps. PMID:22028852

Interactions of task and subject variables among continuous performance tests.

PubMed

Denney, Colin B; Rapport, Mark D; Chung, Kyong-Mee

2005-04-01

Contemporary models of working memory suggest that target paradigm (TP) and target density (TD) should interact as influences on error rates derived from continuous performance tests (CPTs). The present study evaluated this hypothesis empirically in a typically developing, ethnically diverse sample of children. The extent to which scores based on different combinations of these task parameters showed different patterns of relationship to age, intelligence, and gender was also assessed. Four continuous performance tests were derived by combining two target paradigms (AX and repeated letter target stimuli) with two levels of target density (8.3% and 33%). Variations in mean omission (OE) and commission (CE) error rates were examined within and across combinations of TP and TD. In addition, a nested series of structural equation models was utilized to examine patterns of relationship among error rates, age, intelligence, and gender. Target paradigm and target density interacted as influences on error rates. Increasing density resulted in higher OE and CE rates for the AX paradigm. In contrast, the high density condition yielded a decline in OE rates accompanied by a small increase in CEs using the repeated letter CPT. Target paradigms were also distinguishable on the basis of age when using OEs as the performance measure, whereas combinations of age and intelligence distinguished between density levels but not target paradigms using CEs as the dependent measure. Different combinations of target paradigm and target density appear to yield scores that are conceptually and psychometrically distinguishable. Consequently, developmentally appropriate interpretation of error rates across tasks may require (a) careful analysis of working memory and attentional resources required for successful performance, and (b) normative data bases that are differently stratified with respect to combinations of age and intelligence.

On the calibration of continuous, high-precision delta18O and delta2H measurements using an off-axis integrated cavity output spectrometer.

PubMed

Wang, Lixin; Caylor, Kelly K; Dragoni, Danilo

2009-02-01

The (18)O and (2)H of water vapor serve as powerful tracers of hydrological processes. The typical method for determining water vapor delta(18)O and delta(2)H involves cryogenic trapping and isotope ratio mass spectrometry. Even with recent technical advances, these methods cannot resolve vapor composition at high temporal resolutions. In recent years, a few groups have developed continuous laser absorption spectroscopy (LAS) approaches for measuring delta(18)O and delta(2)H which achieve accuracy levels similar to those of lab-based mass spectrometry methods. Unfortunately, most LAS systems need cryogenic cooling and constant calibration to a reference gas, and have substantial power requirements, making them unsuitable for long-term field deployment at remote field sites. A new method called Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS) has been developed which requires extremely low-energy consumption and neither reference gas nor cryogenic cooling. In this report, we develop a relatively simple pumping system coupled to a dew point generator to calibrate an ICOS-based instrument (Los Gatos Research Water Vapor Isotope Analyzer (WVIA) DLT-100) under various pressures using liquid water with known isotopic signatures. Results show that the WVIA can be successfully calibrated using this customized system for different pressure settings, which ensure that this instrument can be combined with other gas-sampling systems. The precisions of this instrument and the associated calibration method can reach approximately 0.08 per thousand for delta(18)O and approximately 0.4 per thousand for delta(2)H. Compared with conventional mass spectrometry and other LAS-based methods, the OA-ICOS technique provides a promising alternative tool for continuous water vapor isotopic measurements in field deployments. Copyright 2009 John Wiley & Sons, Ltd.

Crowding out Latinos: Mexican Americans in the Public Consciousness.

ERIC Educational Resources Information Center

Portales, Marco

Despite efforts to improve perceptions about Mexican Americans and other Spanish-speaking people in the United States, Chicanos and other Latinos are not yet seen as typical American citizens. Latinos continue to receive poor educations, and the media continue to represent them in ways unaffected by the emergence of Chicano literature. This book…

USE OF A CONTINUOUS NEPHELOMETER TO MEASURE PERSONAL EXPOSURE TO PARTICLES DURING THE U.S. EPA BALTIMORE AND FRESNO PANEL STUDIES

EPA Science Inventory

In population exposure studies, personal exposure to particulate matter (PM) is typically measured as a 12- to 24-hour integrated mass concentration. To better understand short-term variation in personal PM exposure, continuous (one-minute averaging time) nephelometers were wo...

The Continuation of Prejudice: Addressing Negative Attitudes in Nurse Training and Continuing Professional Education

ERIC Educational Resources Information Center

Nash, Paul; Stuart-Hamilton, Ian; Mayer, Peter

2014-01-01

Measures of attitudes to ageing typically examine only explicit attitudes, treating attitude holders as a homogeneous group with regards to education levels. Implicit attitudes (i.e., the immediate attitudinal response before conscious processes amend that attitude to an explicit attitude) have been less commonly examined. The current study…

Properties of M components from currents measured at triggered lightning channel base

NASA Astrophysics Data System (ADS)

Thottappillil, Rajeev; Goldberg, Jon D.; Rakov, Vladimir A.; Uman, Martin A.; Fisher, Richard J.; Schnetzer, George H.

1995-12-01

Channel base currents from triggered lightning were measured at the NASA Kennedy Space Center, Florida, during summer 1990 and at Fort McClellan, Alabama, during summer 1991. An analysis of the return stroke data and overall continuing current data has been published by Fisher et al. [1993]. Here an analysis is given of the impulsive processes, called M components, that occur during the continuing current following return strokes. The 14 flashes analyzed contain 37 leader-return stroke sequences and 158 M components, both processes lowering negative charge from cloud to ground. Statistics are presented for the following M current pulse parameters: magnitude, rise time, duration, half-peak width, preceding continuing current level, M interval, elapsed time since the return stroke, and charge transferred by the M current pulse. A typical M component in triggered lightning is characterized by a more or less symmetrical current pulse having an amplitude of 100-200 A (2 orders of magnitude lower than that for a typical return stroke [Fisher et al., 1993]), a 10-90% rise time of 300-500 μs (3 orders of magnitude larger than that for a typical return stroke [Fisher et al., 1993]), and a charge transfer to ground of the order of 0.1 to 0.2 C (1 order of magnitude smaller than that for a typical subsequent return stroke pulse [Berger et al., 1975]). About one third of M components transferred charge greater than the minimum charge reported by Berger et al. [1975] for subsequent leader-return stroke sequences. No correlation was found between either the M charge or the magnitude of the M component current (the two are moderately correlated) and any other parameter considered. M current pulses occurring soon after the return stroke tend to have shorter rise times, shorter durations, and shorter M intervals than those which occur later. M current pulses were observed to be superimposed on continuing currents greater than 30 A or so, with one exception out of 140 cases, wherein the continuing current level was measured to be about 20 A. The first M component virtually always (one exception out of 34 cases) occurred within 4 ms of the return stroke. This relatively short separation time between return stroke and the first M component, coupled with the observation of Fisher et al. [1993] that continuing currents lasting longer than 10 ms never occur without M current pulses, implies that the M component is a necessary feature of the continuing current mode of charge transfer to ground.

77 FR 18709 - Quality Assurance Requirements for Continuous Opacity Monitoring Systems at Stationary Sources

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... Quality Assurance Requirements for Continuous Opacity Monitoring Systems at Stationary Sources AGENCY... direct final rule titled ``Quality Assurance Requirements for Continuous Opacity Monitoring Systems at...--Quality Assurance Requirements for Continuous Opacity Monitoring Systems at Stationary Sources Docket, EPA...

16 CFR Figure 5 to Part 1512 - Typical Handbrake Actuator Showing Grip Dimension

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Typical Handbrake Actuator Showing Grip Dimension 5 Figure 5 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 5 Figure 5 to Part 1512—Typical Handbrake Actuator Showing Grip Dimension...

16 CFR Figure 5 to Part 1512 - Typical Handbrake Actuator Showing Grip Dimension

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Typical Handbrake Actuator Showing Grip Dimension 5 Figure 5 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 5 Figure 5 to Part 1512—Typical Handbrake Actuator Showing Grip Dimension...

Collaborative Problem Solving in Young Typical Development and HFASD

ERIC Educational Resources Information Center

Kimhi, Yael; Bauminger-Zviely, Nirit

2012-01-01

Collaborative problem solving (CPS) requires sharing goals/attention and coordinating actions--all deficient in HFASD. Group differences were examined in CPS (HFASD/typical), with a friend versus with a non-friend. Participants included 28 HFASD and 30 typical children aged 3-6 years and their 58 friends and 58 non-friends. Groups were matched on…

16 CFR Figure 5 to Part 1512 - Typical Handbrake Actuator Showing Grip Dimension

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Typical Handbrake Actuator Showing Grip Dimension 5 Figure 5 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 5 Figure 5 to Part 1512—Typical Handbrake Actuator Showing Grip Dimension...

16 CFR Figure 5 to Part 1512 - Typical Handbrake Actuator Showing Grip Dimension

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Typical Handbrake Actuator Showing Grip Dimension 5 Figure 5 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 5 Figure 5 to Part 1512—Typical Handbrake Actuator Showing Grip Dimension...

16 CFR Figure 5 to Part 1512 - Typical Handbrake Actuator Showing Grip Dimension

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Typical Handbrake Actuator Showing Grip Dimension 5 Figure 5 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR BICYCLES Pt. 1512, Fig. 5 Figure 5 to Part 1512—Typical Handbrake Actuator Showing Grip Dimension...

14 CFR Appendix C to Part 1215 - Typical User Activity Timeline

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Typical User Activity Timeline C Appendix C... RELAY SATELLITE SYSTEM (TDRSS) Pt. 1215, App. C Appendix C to Part 1215—Typical User Activity Timeline... mission model. 3 years before launch (Ref. § 1215.109(c). Submit general user requirements to permit...

Lithological and Surface Geometry Joint Inversions Using Multi-Objective Global Optimization Methods

NASA Astrophysics Data System (ADS)

Lelièvre, Peter; Bijani, Rodrigo; Farquharson, Colin

2016-04-01

Geologists' interpretations about the Earth typically involve distinct rock units with contacts (interfaces) between them. In contrast, standard minimum-structure geophysical inversions are performed on meshes of space-filling cells (typically prisms or tetrahedra) and recover smoothly varying physical property distributions that are inconsistent with typical geological interpretations. There are several approaches through which mesh-based minimum-structure geophysical inversion can help recover models with some of the desired characteristics. However, a more effective strategy may be to consider two fundamentally different types of inversions: lithological and surface geometry inversions. A major advantage of these two inversion approaches is that joint inversion of multiple types of geophysical data is greatly simplified. In a lithological inversion, the subsurface is discretized into a mesh and each cell contains a particular rock type. A lithological model must be translated to a physical property model before geophysical data simulation. Each lithology may map to discrete property values or there may be some a priori probability density function associated with the mapping. Through this mapping, lithological inverse problems limit the parameter domain and consequently reduce the non-uniqueness from that presented by standard mesh-based inversions that allow physical property values on continuous ranges. Furthermore, joint inversion is greatly simplified because no additional mathematical coupling measure is required in the objective function to link multiple physical property models. In a surface geometry inversion, the model comprises wireframe surfaces representing contacts between rock units. This parameterization is then fully consistent with Earth models built by geologists, which in 3D typically comprise wireframe contact surfaces of tessellated triangles. As for the lithological case, the physical properties of the units lying between the contact surfaces are set to a priori values. The inversion is tasked with calculating the geometry of the contact surfaces instead of some piecewise distribution of properties in a mesh. Again, no coupling measure is required and joint inversion is simplified. Both of these inverse problems involve high nonlinearity and discontinuous or non-obtainable derivatives. They can also involve the existence of multiple minima. Hence, one can not apply the standard descent-based local minimization methods used to solve typical minimum-structure inversions. Instead, we are applying Pareto multi-objective global optimization (PMOGO) methods, which generate a suite of solutions that minimize multiple objectives (e.g. data misfits and regularization terms) in a Pareto-optimal sense. Providing a suite of models, as opposed to a single model that minimizes a weighted sum of objectives, allows a more complete assessment of the possibilities and avoids the often difficult choice of how to weight each objective. While there are definite advantages to PMOGO joint inversion approaches, the methods come with significantly increased computational requirements. We are researching various strategies to ameliorate these computational issues including parallelization and problem dimension reduction.

Kangaroo mother care to reduce morbidity and mortality in low birthweight infants.

PubMed

Conde-Agudelo, Agustin; Díaz-Rossello, José L

2014-04-22

Kangaroo mother care (KMC), originally defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from hospital, has been proposed as an alternative to conventional neonatal care for low birthweight (LBW) infants. To determine whether there is evidence to support the use of KMC in LBW infants as an alternative to conventional neonatal care. The standard search strategy of the Cochrane Neonatal Group was used. This included searches in MEDLINE, EMBASE, LILACS, POPLINE, CINAHL databases (all from inception to March 31, 2014) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2014) In addition, we searched the web page of the Kangaroo Foundation, conference and symposia proceedings on KMC, and Google scholar. Randomized controlled trials comparing KMC versus conventional neonatal care, or early onset KMC (starting within 24 hours after birth) versus late onset KMC (starting after 24 hours after birth) in LBW infants. Data collection and analysis were performed according to the methods of the Cochrane Neonatal Review Group. Eighteen studies, including 2751 infants, fulfilled inclusion criteria. Sixteen studies evaluated KMC in LBW infants after stabilization, one evaluated KMC in LBW infants before stabilization, and one compared early onset KMC with late onset KMC in relatively stable LBW infants. Thirteen studies evaluated intermittent KMC and five evaluated continuous KMC. At discharge or 40-41 weeks' postmenstrual age, KMC was associated with a reduction in the risk of mortality (typical risk ratio (RR) 0.60, 95% confidence interval (CI) 0.39 to 0.92; eight trials, 1736 infants), nosocomial infection/sepsis (typical RR 0.45, 95% CI 0.27 to 0.76), hypothermia (typical RR 0.34, 95% CI 0.17 to 0.67), and length of hospital stay (typical mean difference 2.2 days, 95% CI 0.6 to 3.7). At latest follow up, KMC was associated with a decreased risk of mortality (typical RR 0.67, 95% CI 0.48 to 0.95; 11 trials, 2167 infants) and severe infection/sepsis (typical RR 0.56, 95% CI 0.40 to 0.78). Moreover, KMC was found to increase some measures of infant growth, breastfeeding, and mother-infant attachment. There were no significant differences between KMC infants and controls in neurodevelopmental and neurosensory impairment at one year of corrected age. Sensitivity analysis suggested that the inclusion of studies with high risk of bias did not affect the general direction of findings or the size of the treatment effect for the main outcomes. The evidence from this updated review supports the use of KMC in LBW infants as an alternative to conventional neonatal care mainly in resource-limited settings. Further information is required concerning effectiveness and safety of early onset continuous KMC in unstabilized or relatively stabilized LBW infants, long term neurodevelopmental outcomes, and costs of care.

Evaluating public health resources: what happens when funding disappears?

PubMed

Freedman, Ariela M; Kuester, Sarah A; Jernigan, Jan

2013-11-14

Although various factors affect the sustainability of public health programs, funding levels can influence many aspects of program continuity. Program evaluation in public health typically does not assess the progress of initiatives after discontinuation of funding. The objective of this study was to describe the effect of funding loss following expiration of a 5-year federal grant awarded to state health departments for development of statewide obesity prevention partnerships. The study used qualitative methods involving semistructured key informant interviews with state health departments. Data were analyzed using thematic analysis for effect of funding loss on staffing, programs, partnerships, and implementation of state plans. Many of the programs that continued to run after the grant expired operated at reduced capacity, either reaching fewer people or conducting fewer program activities for the same population. Although many states were able to leverage funding from other sources, this shift in funding source often resulted in priorities changing to meet new funding requirements. Evaluation capacity suffered in all states. Nearly all states reported losing infrastructure and capacity to communicate widely with partners. All states reported a severe or complete loss of their ability to provide training and technical assistance to partners. Despite these reduced capacities, states reported several key resources that facilitated continued work on the state plan. Decisions regarding continuation of funding are often dependent on budget constraints, evidence of success, and perceived ability to succeed in the future. Evaluating public health funding decisions may help guide development of best practice strategies for supporting long-term program success.

An Evaluation of the Consumer Costs and Benefits of Energy Efficiency Resource Standards

NASA Astrophysics Data System (ADS)

Lessans, Mark D.

Of the modern-day policies designed to encourage energy efficiency, one with a significant potential for impact is that of Energy Efficiency Resource Standards (EERS). EERS policies place the responsibility for meeting an efficiency target on the electric and gas utilities, typically setting requirements for annual reductions in electricity generation or gas distribution to customers as a percentage of sales. To meet these requirements, utilities typically implement demand-side management (DSM) programs, which encourage energy efficiency at the customer level through incentives and educational initiatives. In Maryland, a statewide EERS has provided for programs which save a significant amount of energy, but is ultimately falling short in meeting the targets established by the policy. This study evaluates residential DSM programs offered by Pepco, a utility in Maryland, for cost-effectiveness. However, unlike most literature on the topic, analysis focuses on the costs-benefit from the perspective of the consumer, and not the utility. The results of this study are encouraging: the majority of programs analyzed show that the cost of electricity saved, or levelized cost of saved energy (LCSE), is less expensive than the current retail cost of electricity cost in Maryland. A key goal of this study is to establish a metric for evaluating the consumer cost-effectiveness of participation in energy efficiency programs made available by EERS. In doing so, the benefits of these programs can be effectively marketed to customers, with the hope that participation will increase. By increasing consumer awareness and buy-in, the original goals set out through EERS can be realized and the policies can continue to receive support.

Study for identification of Beneficial uses of Space (BUS). Volume 3: Appendices

NASA Technical Reports Server (NTRS)

1975-01-01

The quantification of required specimen(s) from space processing experiments, the typical EMI measurements and estimates of a typical RF source, and the integration of commercial payloads into spacelab were considered.

Nondestructive measurement of esophageal biaxial mechanical properties utilizing sonometry

NASA Astrophysics Data System (ADS)

Aho, Johnathon M.; Qiang, Bo; Wigle, Dennis A.; Tschumperlin, Daniel J.; Urban, Matthew W.

2016-07-01

Malignant esophageal pathology typically requires resection of the esophagus and reconstruction to restore foregut continuity. Reconstruction options are limited and morbid. The esophagus represents a useful target for tissue engineering strategies based on relative simplicity in comparison to other organs. The ideal tissue engineered conduit would have sufficient and ideally matched mechanical tolerances to native esophageal tissue. Current methods for mechanical testing of esophageal tissues both in vivo and ex vivo are typically destructive, alter tissue conformation, ignore anisotropy, or are not able to be performed in fluid media. The aim of this study was to investigate biomechanical properties of swine esophageal tissues through nondestructive testing utilizing sonometry ex vivo. This method allows for biomechanical determination of tissue properties, particularly longitudinal and circumferential moduli and strain energy functions. The relative contribution of mucosal-submucosal layers and muscular layers are compared to composite esophagi. Swine thoracic esophageal tissues (n  =  15) were tested by pressure loading using a continuous pressure pump system to generate stress. Preconditioning of tissue was performed by pressure loading with the pump system and pre-straining the tissue to in vivo length before data was recorded. Sonometry using piezocrystals was utilized to determine longitudinal and circumferential strain on five composite esophagi. Similarly, five mucosa-submucosal and five muscular layers from thoracic esophagi were tested independently. This work on esophageal tissues is consistent with reported uniaxial and biaxial mechanical testing and reported results using strain energy theory and also provides high resolution displacements, preserves native architectural structure and allows assessment of biomechanical properties in fluid media. This method may be of use to characterize mechanical properties of tissue engineered esophageal constructs.

Control Algorithms Charge Batteries Faster

NASA Technical Reports Server (NTRS)

2012-01-01

On March 29, 2011, NASA s Mercury Surface, Space Environment, Geochemistry and Ranging (MESSENGER) spacecraft beamed a milestone image to Earth: the first photo of Mercury taken from orbit around the solar system s innermost planet. (MESSENGER is also the first spacecraft to orbit Mercury.) Like most of NASA s deep space probes, MESSENGER is enabled by a complex power system that allows its science instruments and communications to function continuously as it travels millions of miles from Earth. "Typically, there isn't one particular power source that can support the entire mission," says Linda Taylor, electrical engineer in Glenn Research Center s Power Systems Analysis Branch. "If you have solar arrays and you are in orbit, at some point you re going to be in eclipse." Because of this, Taylor explains, spacecraft like MESSENGER feature hybrid power systems. MESSENGER is powered by a two-panel solar array coupled with a nickel hydrogen battery. The solar arrays provide energy to the probe and charge the battery; when the spacecraft s orbit carries it behind Mercury and out of the Sun s light, the spacecraft switches to battery power to continue operations. Typically, hybrid systems with multiple power inputs and a battery acting alternately as storage and a power source require multiple converters to handle the power flow between the devices, Taylor says. (Power converters change the qualities of electrical energy, such as from alternating current to direct current, or between different levels of voltage or frequency.) This contributes to a pair of major concerns for spacecraft design. "Weight and size are big drivers for any space application," Taylor says, noting that every pound added to a space vehicle incurs significant costs. For an innovative solution to managing power flows in a lightweight, cost-effective manner, NASA turned to a private industry partner.

A unifying model for planform straightness of ripples and dunes in air and water

USGS Publications Warehouse

Rubin, David M.

2012-01-01

Geologists, physicists, and mathematicians have studied ripples and dunes for more than a century, but despite considerable effort, no general model has been proposed to explain perhaps the most fundamental property of their morphology: why are some bedforms straight, continuous, parallel, and uniform in planform geometry (i.e. two-dimensional) whereas others are irregular (three-dimensional)? Here we argue that physical coupling along the crest of a bedform is required to produce straight crests and that along-crest flow and sand transport provide effective physical mechanisms for that coupling. Ripples and dunes with the straightest and most continuous crests include longitudinal and oblique dunes in unidirectional flows, wave ripples, dunes in reversing flows, wind ripples, and ripples migrating along a slope. At first glance, these bedforms appear quite different (ripples and dunes; air and water; transverse, oblique, and longitudinal orientations relative to the net sand-transport direction), but they all have one property in common: a process that increases the amount of along-crest sand transport (that lengthens and straightens their crests) relative to the across-crest transport (that makes them migrate and take the more typical and more three-dimensional planform geometry). In unidirectional flows that produce straight bedforms, along-crest transport of sand is caused by along-crest flow (non-transverse bedform orientation), gravitational transport along an inclined crest, or ballistic splash in air. Bedforms in reversing flows tend to be straighter than their unidirectional counterparts, because reverse transport across the bedform crest reduces the net across-crest transport (that causes the more typical irregular geometry) relative to the along-crest transport (that smoothes and straightens planform geometry).

Reading Development in Typically Developing Children and Children with Prenatal or Perinatal Brain Lesions: Differential School Year and Summer Growth

ERIC Educational Resources Information Center

Demir-Lira, Özlem Ece; Levine, Susan C.

2016-01-01

Summer slide, uneven growth of academic skills during the calendar year, captures the fact that the learning gains children make during the school year do not continue at the same pace over the summer, when children are typically not in school. We compared growth of reading skills during the school year and during the summer months in children…

Experiments with a Supersonic Multi-Channel Radial Diffuser.

DTIC Science & Technology

1980-09-01

unlimited. 17 . DISTRIBUTION STATEMENT (o the *bsta~c entered nRItok 20, it dffttt Iton, Report) IS. SUPPLEMENTARY NOTES 19. KEY WORDS (Continue o...Improvements 17 VI SIGNIFICANT TEST RESULTS 20 1. General Considerations 20 2. Typical Radial Diffuser Performance 20 3. Flow Stability Experiments 22 VIII...Adjustments Indicated 39 16 Comparison of the Single Channel Performances for Two Extreme Channel Geometries 40 17 Typical Radial Diffuser Performance

40 CFR 60.1245 - Am I exempt from any appendix B or appendix F requirements to evaluate continuous emission...

Code of Federal Regulations, 2011 CFR

2011-07-01

... appendix F requirements to evaluate continuous emission monitoring systems? 60.1245 Section 60.1245... appendix F requirements to evaluate continuous emission monitoring systems? Yes, the accuracy tests for your sulfur dioxide continuous emission monitoring system require you to also evaluate your oxygen (or...

40 CFR 60.1245 - Am I exempt from any appendix B or appendix F requirements to evaluate continuous emission...

Code of Federal Regulations, 2010 CFR

2010-07-01

... appendix F requirements to evaluate continuous emission monitoring systems? 60.1245 Section 60.1245... appendix F requirements to evaluate continuous emission monitoring systems? Yes, the accuracy tests for your sulfur dioxide continuous emission monitoring system require you to also evaluate your oxygen (or...

Optical techniques for biological triggers and identifiers

NASA Astrophysics Data System (ADS)

Grant, Bruce A. C.

2004-12-01

Optical techniques for the classification and identification of biological particles provide a number of advantages over traditional 'Wet Chemistry" methods, amongst which are speed of response and the reduction/elimination of consumables. These techniques can be employed in both 'Trigger" and 'Identifier" systems. Trigger systems monitor environmental particulates with the aim of detecting 'unusual" changes in the overall environmental composition and providing an indication of threat. At the present time there is no single optical measurement that can distinguish between benign and hostile events. Therefore, in order to distinguish between these 2 classifications, a number of different measurements must be effected and a decision made on the basis of the 'integrated" data. Smiths Detection have developed a data gathering platform capable of measuring multiple optical, physical and electrical parameters of individual airborne biological particles. The data from all these measurements are combined in a hazard classification algorithm based on Bayesian Inference techniques. Identifier systems give a greater level of information and confidence than triggers, -- although they require reagents and are therefore much more expensive to operate -- and typically take upwards of 20 minutes to respond. Ideally, in a continuous flow mode, identifier systems would respond in real-time, and identify a range of pathogens specifically and simultaneously. The results of recent development work -- carried out by Smiths Detection and its collaborators -- to develop an optical device that meets most of these requirements, and has the stretch potential to meet all of the requirements in a 3-5 year time frame will be presented. This technology enables continuous stand-alone operation for both civil and military defense applications and significant miniaturisation can be achieved with further development.

Interior Western U. S. Deformation Coming into Focus with Maturing Survey and Continuous GPS Networks

NASA Astrophysics Data System (ADS)

Thatcher, W. R.; Svarc, J. L.

2010-12-01

Active Basin and Range (BR) extension produces spectacular fault-generated topography spread over ~800 km in the interior western US. However, present-day deformation rates are relatively low east of the San Andreas fault system and Cascadia subduction zone and ± 1 mm/yr precision in GPS velocity is needed to pinpoint the major faults that accommodate extension. Typically, 3 years of continuous (CGPS) operation and 8 years of sparsely repeated survey (SGPS) network occupations are required to attain this precision. U. S. Geological Survey (USGS) survey networks and Plate Boundary Observatory (PBO) continuous station records are now long enough to meet these requirements. USGS and PBO station coverage is generally complementary. PBO coverage established since 2005 within the ~1000 km x 1500 km deforming zone is relatively complete at ~100 km station spacing; USGS survey-mode profiles established during 1999-2003 are dense; typical station spacing is ~25 km and results are sufficiently precise to determine localized velocity gradients of 1 mm/yr or greater (over ~25-50 km distances) across mapped active strike-slip and normal faults traversed by the SGPS profiles. The great majority of geologically young faults appear to slip at rates less than 1 mm/yr but rates are measurably higher near the western and eastern edges of the BR. There is a marked transition in NE California from strike-slip faulting at rates of ~ 4 mm/yr across the northern Walker Lane zone to pure extension north of about Mt. Lassen. This distinct boundary is apparently related to the prevalence of strike-slip tractions on the San Andreas plate boundary south of the Mendocino triple junction (MTJ) to tensile stresses caused by Cascadia slab retreat north of the MTJ. A horizontal extension rate of 3 mm/yr is observed across the north-striking Hat Creek and related normal faults immediately north of Lassen, but this extension decreases to no more than 1 mm/yr in the Klamath Basin, about 150 km to the north. Extension rates could be as high as ~1 mm/yr across the Surprise Valley fault (near the California-Nevada border) and the Steens Mountain-Pueblo Mountains fault (SE Oregon). But elsewhere in Oregon, Idaho and Montana, extension rates are < 1 mm/yr and only on the eastern edge of the BR, across the Wasatch and related faults in central Utah, do rates reach 3 mm/yr.

Cost Efficiency of Sea Freight and Lowering Cost of Consumption Goods

NASA Astrophysics Data System (ADS)

Rum, Muh

2018-05-01

The subject of this research are administrative processes related to loading and unloading costin term of a ship’s arrival and departure to seaports,typically attributed to elevated levels of cost of labor, handling cost, dwelling time, and port fee which required to complete the related administrative tasks. Research design by comparative method in administrative way, which compare with many way implemented of previous practitioner export and import. In the previous phases of the research, an average expected cost of the administrative labor cost in traditional seaport clusters in eastern Indonesia was identified and quantified on an hourly basis. This research continues in its aim by using the results of the previous research as a starting point, and Find that enterprise resource planning and improvement, transactional due diligence and merger integration, positively affect and not associated with cost reduction. Moreover variable of reducing inventory cost affect and associated with reducing cost. The main hypothesis is that the usage of such a new model will result in a measurable decrease of the required freight cost in sea port, which indirectly reduce the consumption goods.

Foil Bearing Starting Considerations and Requirements for Rotorcraft Engine Applications

NASA Technical Reports Server (NTRS)

Radil, Kevin C.; DellaCorte, Christopher

2009-01-01

Foil gas bearings under development for rotorcraft-sized, hot core engine applications have been susceptible to damage from the slow acceleration and rates typically encountered during the pre-ignition stage in conventional engines. Recent laboratory failures have been assumed to be directly linked to operating foil bearings below their lift-off speed while following conventional startup procedures for the engines. In each instance, the continuous sliding contact between the foils and shaft was believed to thermally overload the bearing and cause the engines to fail. These failures highlight the need to characterize required acceleration rates and minimum operating speeds for these applications. In this report, startup experiments were conducted with a large, rotorcraft engine sized foil bearing under moderate load and acceleration rates to identify the proper start procedures needed to avoid bearing failure. The results showed that a bearing under a 39.4 kPa static load can withstand a modest acceleration rate of 500 rpm/s and excessive loitering below the bearing lift-off speed provided an adequate solid lubricant is present.

Decongestion: Diuretics and other therapies for hospitalized heart failure

PubMed Central

Vazir, Ali; Cowie, Martin R.

2016-01-01

Acute heart failure (AHF) is a potentially life-threatening clinical syndrome, usually requiring hospital admission. Often the syndrome is characterized by congestion, and is associated with long hospital admissions and high risk of readmission and further healthcare expenditure. Despite a limited evidence-base, diuretics remain the first-line treatment for congestion. Loop diuretics are typically the first-line diuretic strategy with some evidence that initial treatment with continuous infusion or boluses of high-dose loop diuretic is superior to an initial lower dose strategy. In patients who have impaired responsiveness to diuretics, the addition of an oral thiazide or thiazide-like diuretic to induce sequential nephron blockade can be beneficial. The use of intravenous low-dose dopamine is no longer supported in heart failure patients with preserved systolic blood pressure and its use to assist diuresis in patients with low systolic blood pressures requires further study. Mechanical ultrafiltration has been used to treat patients with heart failure and fluid retention, but the evidence-base is not robust, and its place in clinical practice is yet to be established. Several novel pharmacological agents remain under investigation. PMID:27056656

Nanotechnology, resources, and pollution control

NASA Astrophysics Data System (ADS)

Gillett, Stephen L.

1996-09-01

The separation of different kinds of atoms or molecules from each other is a fundamental technological problem. Current techniques of resource extraction, which use the ancient paradigm of the differential partitioning of elements into coexisting phases, are simple but extremely wasteful and require feedstocks (`ores') that are already anomalously enriched. This is impractical for pollution control and desalination, which require extraction of low concentrations; instead, atomistic separation, typically by differential motion through semipermeable membranes, is used. The present application of such membranes is seriously limited, however, mostly because of limitations in their fabrication by conventional bulk techniques. The capabilities of biological systems, such as vertebrate kidneys, are vastly better, largely because they are intrinsically structured at a molecular scale. Nanofabrication of semipermeable membranes promises capabilities on the order of those of biological systems, and this in turn could provide much financial incentive for the development of molecular assemblers, as well established markets exist already. Continued incentives would exist, moreover, as markets expanded with decreasing costs, leading to such further applications as remediation of polluted sites, cheap desalination, and resource extraction from very low-grade sources.

Assimilating concentration observations for transport and dispersion modeling in a meandering wind field

NASA Astrophysics Data System (ADS)

Haupt, Sue Ellen; Beyer-Lout, Anke; Long, Kerrie J.; Young, George S.

Assimilating concentration data into an atmospheric transport and dispersion model can provide information to improve downwind concentration forecasts. The forecast model is typically a one-way coupled set of equations: the meteorological equations impact the concentration, but the concentration does not generally affect the meteorological field. Thus, indirect methods of using concentration data to influence the meteorological variables are required. The problem studied here involves a simple wind field forcing Gaussian dispersion. Two methods of assimilating concentration data to infer the wind direction are demonstrated. The first method is Lagrangian in nature and treats the puff as an entity using feature extraction coupled with nudging. The second method is an Eulerian field approach akin to traditional variational approaches, but minimizes the error by using a genetic algorithm (GA) to directly optimize the match between observations and predictions. Both methods show success at inferring the wind field. The GA-variational method, however, is more accurate but requires more computational time. Dynamic assimilation of a continuous release modeled by a Gaussian plume is also demonstrated using the genetic algorithm approach.

Superconducting radio-frequency cavities made from medium and low-purity niobium ingots

DOE PAGES

Ciovati, Gianluigi; Dhakal, Pashupati; Myneni, Ganapati R.

2016-04-07

Superconducting radio-frequency cavities made of ingot niobium with residual resistivity ratio (RRR) greater than 250 have proven to have similar or better performance than fine-grain Nb cavities of the same purity, after standard processing. The high purity requirement contributes to the high cost of the material. As superconducting accelerators operating in continuous-wave typically require cavities to operate at moderate accelerating gradients, using lower purity material could be advantageous not only to reduce cost but also to achieve higher Q 0-values. In this contribution we present the results from cryogenic RF tests of 1.3–1.5 GHz single-cell cavities made of ingot Nbmore » of medium (RRR = 100–150) and low (RRR = 60) purity from different suppliers. Cavities made of medium-purity ingots routinely achieved peak surface magnetic field values greater than 70 mT with an average Q 0-value of 2 × 10 10 at 2 K after standard processing treatments. As a result, the performances of cavities made of low-purity ingots were affected by significant pitting of the surface after chemical etching.« less

A Wirelessly Powered Micro-Spectrometer for Neural Probe-Pin Device

NASA Technical Reports Server (NTRS)

Choi, Sang H.; Kim, Min Hyuck; Song, Kyo D.; Yoon, Hargsoon; Lee, Uhn

2015-01-01

Treatment of neurological anomalies, places stringent demands on device functionality and size. A micro-spectrometer has been developed for use as an implantable neural probe to monitor neuro-chemistry in synapses. The microspectrometer, based on a NASA-invented miniature Fresnel grating, is capable of differentiating the emission spectra from various brain tissues. The micro-spectrometer meets the size requirements, and is able to probe the neuro-chemistry and suppression voltage typically associated with a neural anomaly. This neural probe-pin device (PPD) is equipped with wireless power technology (WPT) enabling operation in a continuous manner without requiring an implanted battery. The implanted neural PPD, together with a neural electronics interface and WPT, allow real-time measurement and control/feedback for remediation of neural anomalies. The design and performance of the combined PPD/WPT device for monitoring dopamine in a rat brain will be presented to demonstrate the current level of development. Future work on this device will involve the addition of an embedded expert system capable of performing semi-autonomous management of neural functions through a routine of sensing, processing, and control.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duchaineau, M.; Wolinsky, M.; Sigeti, D.E.

Terrain visualization is a difficult problem for applications requiring accurate images of large datasets at high frame rates, such as flight simulation and ground-based aircraft testing using synthetic sensor stimulation. On current graphics hardware, the problem is to maintain dynamic, view-dependent triangle meshes and texture maps that produce good images at the required frame rate. We present an algorithm for constructing triangle meshes that optimizes flexible view-dependent error metrics, produces guaranteed error bounds, achieves specified triangle counts directly, and uses frame-to-frame coherence to operate at high frame rates for thousands of triangles per frame. Our method, dubbed Real-time Optimally Adaptingmore » Meshes (ROAM), uses two priority queues to drive split and merge operations that maintain continuous triangulations built from pre-processed bintree triangles. We introduce two additional performance optimizations: incremental triangle stripping and priority-computation deferral lists. ROAM execution time is proportionate to the number of triangle changes per frame, which is typically a few percent of the output mesh size, hence ROAM performance is insensitive to the resolution and extent of the input terrain. Dynamic terrain and simple vertex morphing are supported.« less

A Matrix Metalloproteinase Mediates Airway Remodeling in Drosophila

PubMed Central

Glasheen, Bernadette M.; Robbins, Renée M.; Piette, Caitlin; Beitel, Greg J.; Page-McCaw, Andrea

2010-01-01

Organ size typically increases dramatically during juvenile growth. This growth presents a fundamental tension, as organs need resiliency to resist stresses while still maintaining plasticity to accommodate growth. Extracellular matrix (ECM) is central to providing resiliency, but how ECM is remodeled to accommodate growth is poorly understood. We investigated remodeling of Drosophila respiratory tubes (tracheae) that elongate continually during larval growth, despite being lined with a rigid cuticular ECM. Cuticle is initially deposited with a characteristic pattern of repeating ridges and valleys known as taenidia. We find that for tubes to elongate, the extracellular protease Mmp1 is required for expansion of ECM between the taenidial ridges during each inter-molt period. Mmp1 protein localizes in periodically-spaced puncta that are in register with the taenidial spacing. Mmp1 also degrades old cuticle at molts, promotes apical membrane expansion in larval tracheae, and promotes tube elongation in embryonic tracheae. Whereas work in other developmental systems has demonstrated that MMPs are required for axial elongation occurring in localized growth zones, this study demonstrates that MMPs can also mediate interstitial matrix remodeling during growth of an organ system. PMID:20513443

A wirelessly powered microspectrometer for neural probe-pin device

NASA Astrophysics Data System (ADS)

Choi, Sang H.; Kim, Min H.; Song, Kyo D.; Yoon, Hargsoon; Lee, Uhn

2015-12-01

Treatment of neurological anomalies, whether done invasively or not, places stringent demands on device functionality and size. We have developed a micro-spectrometer for use as an implantable neural probe to monitor neuro-chemistry in synapses. The micro-spectrometer, based on a NASA-invented miniature Fresnel grating, is capable of differentiating the emission spectra from various brain tissues. The micro-spectrometer meets the size requirements, and is able to probe the neuro-chemistry and suppression voltage typically associated with a neural anomaly. This neural probe-pin device (PPD) is equipped with wireless power technology (WPT) to enable operation in a continuous manner without requiring an implanted battery. The implanted neural PPD, together with a neural electronics interface and WPT, enable real-time measurement and control/feedback for remediation of neural anomalies. The design and performance of the combined PPD/WPT device for monitoring dopamine in a rat brain will be presented to demonstrate the current level of development. Future work on this device will involve the addition of an embedded expert system capable of performing semi-autonomous management of neural functions through a routine of sensing, processing, and control.

Acceleration of high-pressure-ratio single-spool turbojet engine as determined from component performance characteristics I : effect of air bleed at compressor outlet

NASA Technical Reports Server (NTRS)

Rebeske, John J , Jr; Rohlik, Harold E

1953-01-01

An analytical investigation was made to determine from component performance characteristics the effect of air bleed at the compressor outlet on the acceleration characteristics of a typical high-pressure-ratio single-spool turbojet engine. Consideration of several operating lines on the compressor performance map with two turbine-inlet temperatures showed that for a minimum acceleration time the turbine-inlet temperature should be the maximum allowable, and the operating line on the compressor map should be as close to the surge region as possible throughout the speed range. Operation along such a line would require a continuously varying bleed area. A relatively simple two-step area bleed gives only a small increase in acceleration time over a corresponding variable-area bleed. For the modes of operation considered, over 84 percent of the total acceleration time was required to accelerate through the low-speed range ; therefore, better low-speed compressor performance (higher pressure ratios and efficiencies) would give a significant reduction in acceleration time.

European Mobile Satellite Services (EMSS): A regional system for Europe

NASA Technical Reports Server (NTRS)

Loisy, C.; Edin, P.; Benedicto, F. J.

1995-01-01

The European Space Agency is presently procuring two L-band payloads in order to promote a regional system for the provision of European Mobile Satellite Services (EMSS). These are the EMS payload on the Italsat I-F2 satellite and the LLM payload on the ARTEMIS satellite. Telecommunication system studies have been concentrating on mobile applications where full European geographical coverage is required. Potential applications include high priority Private Mobile Radio networks requiring national or European coverage, such as civil security, fire brigades, police and health services, as well as a dedicated system for provision of Air Traffic Services to the civil aviation community. A typical application is an intelligent road traffic management system combining a geographically selective traffic data collection service based on probe vehicles with a geographically selective traffic information broadcast service. Network architectures and bearer services have been developed both for data only and voice/data services. Vehicle mounted mobile transceivers using CDMA access techniques have been developed. The EMSS operational phase will start with the EMS payload in orbit in 1996 and continue with the LLM payload in 1997.

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

23 CFR 777.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... substances into organic matter and recycled on a continuing basis. Compensatory mitigation means restoration... normal circumstances do support, a prevalence of vegetation typically adapted for life in saturated soil...

40 CFR 60.1275 - What additional requirements must I meet for the operation of my continuous emission monitoring...

Code of Federal Regulations, 2010 CFR

2010-07-01

... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring... additional requirements must I meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values and applicable performance specifications...

40 CFR 60.1275 - What additional requirements must I meet for the operation of my continuous emission monitoring...

Code of Federal Regulations, 2011 CFR

2011-07-01

... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring... additional requirements must I meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values and applicable performance specifications...

Redo pullthrough for Hirschsprung disease.

PubMed

Ralls, Matthew W; Coran, Arnold G; Teitelbaum, Daniel H

2017-04-01

Pullthrough procedures for Hirschsprung diseases typically have favorable results. However, some children experience long-term postoperative complications comprising stooling disorders, such as intermittent enterocolitis, severe stool retention, intestinal obstruction, as well as incontinence. Reoperative Hirschsprung Disease surgery is complex. This begins with the workup after the initial presentation following primary pullthrough, continues with the definitive surgical correction with redo pullthrough, and ends with long-term follow-up of individuals. The decision tree can be varied with each patient. The operating pediatric surgeon must be able to utilize different operations and treatment options available. While lesser procedures may provide relief in a select population, those with residual aganglionosis or transition zone pathology or mechanical problems will likely require a redo pullthrough. Thus, the diagnostic workup, treatment plan, and definitive surgical care should be coordinated, and executed by an experienced, specialized team at a pediatric referral center.

Failure Control Techniques for the SSME

NASA Technical Reports Server (NTRS)

Taniguchi, M. H.

1987-01-01

Since ground testing of the Space Shuttle Main Engine (SSME) began in 1975, the detection of engine anomalies and the prevention of major damage have been achieved by a multi-faceted detection/shutdown system. The system continues the monitoring task today and consists of the following: sensors, automatic redline and other limit logic, redundant sensors and controller voting logic, conditional decision logic, and human monitoring. Typically, on the order of 300 to 500 measurements are sensed and recorded for each test, while on the order of 100 are used for control and monitoring. Despite extensive monitoring by the current detection system, twenty-seven (27) major incidents have occurred. This number would appear insignificant compared with over 1200 hot-fire tests which have taken place since 1976. However, the number suggests the requirement for and future benefits of a more advanced failure detection system.

Creating a culture of innovation in nursing education through shared vision, leadership, interdisciplinary partnerships, and positive deviance.

PubMed

Melnyk, Bernadette Mazurek; Davidson, Sandra

2009-01-01

Although innovation is typically viewed by healthcare and academic institutions, business leaders, entrepreneurs, and private corporations as necessary for continuous improvement, high-quality care, and scientific advancement, barriers in creating and sustaining innovative academic environments abound and require effective leadership to overcome them. Therefore, the purpose of this article is to describe the major barriers and facilitators to innovation in colleges of nursing and healthcare professions along with recommendations for creating a culture of innovation in these academic environments. In addition, key strategies for educational innovation are discussed. Innovations launched by the Arizona State University College of Nursing & Healthcare Innovation are highlighted to provide examples of how a college that established innovation as a top priority in 2005 in its strategic plan created an innovative culture that has led to several successful outcomes.

Enhanced Characterization of Niobium Surface Topography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen Xu, Hui Tian, Charles Reece, Michael Kelley

2011-12-01

Surface topography characterization is a continuing issue for the Superconducting Radio Frequency (SRF) particle accelerator community. Efforts are underway to both to improve surface topography, and its characterization and analysis using various techniques. In measurement of topography, Power Spectral Density (PSD) is a promising method to quantify typical surface parameters and develop scale-specific interpretations. PSD can also be used to indicate how chemical processes modifiesy the roughnesstopography at different scales. However, generating an accurate and meaningful topographic PSD of an SRF surface requires careful analysis and optimization. In this report, polycrystalline surfaces with different process histories are sampled with AFMmore » and stylus/white light interferometer profilometryers and analyzed to indicate trace topography evolution at different scales. evolving during etching or polishing. Moreover, Aan optimized PSD analysis protocol will be offered to serve the SRF surface characterization needs is presented.« less

Orbiter Kapton wire operational requirements and experience

NASA Technical Reports Server (NTRS)

Peterson, R. V.

1994-01-01

The agenda of this presentation includes the Orbiter wire selection requirements, the Orbiter wire usage, fabrication and test requirements, typical wiring installations, Kapton wire experience, NASA Kapton wire testing, summary, and backup data.

Fulminant type 1 diabetes mellitus: a study of nine cases.

PubMed

Su, Xiao-Fei; Fu, Li-Yuan; Wu, Jin-Dan; Xu, Xiao-Hua; Li, Hui-Qin; Sun, Rui; Ye, Lei; Lee, Kok-Onn; Ma, Jian-Hua

2012-04-01

The study aims to explore the prevalence and clinical features of fulminant type 1 diabetes mellitus (F1DM). We analyzed 11,202 patients who were diagnosed having diabetes and admitted to the Department of Endocrinology, Nanjin First Hospital, Nanjin, China, from September 2005 to April 2011. Among 198 patients classified having type 1 diabetes mellitus (T1DM), nine patients were diagnosed having F1DM. Clinical features of F1DM were analyzed and compared with typical T1DM. The prevalence of F1DM was 4.5% (nine of 198 T1DM patients) in this study. F1DM patients had significantly high levels of random blood glucose (40±9 mmol/L). However, glycated hemoglobin (7.1±1.0%) and C-reactive peptide (0.21±0.15 μg/L) at 2 h postprandial were significantly lower in F1DM patients compared with typical T1DM patients. Six of them had flu-like symptoms. Five of them showed gastrointestinal symptoms. Three patients experienced disturbance of consciousness. However, none of these symptoms was found in patients with typical T1DM. A continuous intravenous insulin infusion therapy using a portable pump was given during the acute phase to control hyperglycemia and ketoacidosis. All F1DM patients survived after treatment. In this single hospital-based study, nine Chinese patients met the criteria for diagnosis of F1DM. Although F1DM may be fatal, prompt treatment is required and useful to rescue these patients.

Pelvic Inlet Shape Is Not as Dimorphic as Previously Suggested.

PubMed

Delprete, Hillary

2017-04-01

It is well known that there are significant differences in the pelves of males and females due, in part, to differing constraints. The male and female pelves must be suitable for upright posture and locomotion, but the female pelvis must also be suitable for reproduction. These differing requirements lead to differences in the shape and size of various pelvic dimensions. These differences are reflected in the pelvic inlet, midplane, and outlet. Current research has documented dimorphisms in the posterior and anterior spaces in all three of these planes. One measure however, that is calculated from the relationship between the length of the anterior-posterior diameter (APD) and the transverse diameter (TD) of the inlet, is not as dimorphic as previously suggested. This computed value is used to describe four main categories of inlet shape: android, gynecoid, anthropoid, and platypelloid. Current textbooks in anatomy and midwifery describe these forms and identify the typical male inlet shape as android and the typical female inlet shape as gynecoid. In this study, however, using skeletonized pelves of 378 adult individuals from three identified skeletal collections, the most common inlet shape for both males and females was android. In addition, when examining shape as a continuous variable, inlet shape is not sexually dimorphic in two of the three populations examined in this study. Based on the results of this study, the inlet shape for males and females is less dimorphic than previously thought, and we need to discontinue using pelvic categories to describe typical inlet shape. Anat Rec, 300:706-715, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

7 CFR 1944.407 - Limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.407 Limitations. The amount of... typical needed repairs, and the cost savings between self-help and contractor rehabilitation and repair...

40 CFR 62.15190 - Am I exempt from any 40 CFR part 60 appendix B or appendix F requirements to evaluate continuous...

Code of Federal Regulations, 2010 CFR

2010-07-01

... appendix B or appendix F requirements to evaluate continuous emission monitoring systems? 62.15190 Section... evaluate continuous emission monitoring systems? Yes, the accuracy tests for your sulfur dioxide continuous emission monitoring system require you to also evaluate your oxygen (or carbon dioxide) continuous emission...

40 CFR 62.15190 - Am I exempt from any 40 CFR part 60 appendix B or appendix F requirements to evaluate continuous...

Code of Federal Regulations, 2011 CFR

2011-07-01

... appendix B or appendix F requirements to evaluate continuous emission monitoring systems? 62.15190 Section... evaluate continuous emission monitoring systems? Yes, the accuracy tests for your sulfur dioxide continuous emission monitoring system require you to also evaluate your oxygen (or carbon dioxide) continuous emission...

Past, present, and future roles of child protective services.

PubMed

Schene, P A

1998-01-01

Contemporary social issues typically spring from historical roots, and, as this article points out, that is particularly true of the effort to find a balanced, fair, and helpful way of responding to child abuse and neglect. This article examines how today's child protective services system evolved from a past of almshouses, orphan trains, anticruelty societies, and legislation establishing the protection of children as a government function. The author finds that the history of child protection in the United States is marked by a continuing, unresolved tension between the aim of rescuing children from abusive homes and that of strengthening the care their families can provide. Against that backdrop, this article explains the structure of the typical child protective services (CPS) agency (the unit within a broader public child welfare department that focuses on abuse and neglect) and outlines the roles in child protection that are played by the police, the courts, private and public social service agencies, and the community at large. According to the author's analysis, the fundamental challenges facing CPS can be captured in two questions regarding appropriate boundaries for the agency: Which situations require the agency's intervention? And how can the broader resources of the community be mobilized in the effort to protect children?

Design, fabrication and performance of small, graphite electrode, multistage depressed collectors with 200-W, CW, 8- to 18-GHz traveling-wave tubes

NASA Technical Reports Server (NTRS)

Ebihara, Ben T.; Ramins, Peter

1987-01-01

Small multistage depressed collectors (MDC's) which used pyrolytic graphite, ion-beam-textured pyrolytic graphite, and isotropic graphite electrodes were designed, fabricated, and evaluated in conjuntion with 200-W, continuous wave (CW), 8- to 18-GHz traveling-wave tubes (TWT's). The design, construction, and performance of the MDC's are described. The bakeout performance of the collectors, in terms of gas evolution, was indistinguishable from that of typical production tubes with copper collectors. However, preliminary results indicate that some additional radiofrequency (RF) and dc beam processing time (and/or longer or higher temperature bakeouts) may be needed beyond that of typical copper electrode collectors. This is particularly true for pyrolytic graphite electrodes and for TWT's without appendage ion pumps. Extended testing indicated good long-term stability of the textured pyrolytic graphite and isotropic graphite electrode surfaces. The isotropic graphite in particular showed considerable promise as an MDC electrode material because of its high purity, low cost, simple construction, potential for very compact overall size, and relatively low secondary electron emission yield characteristics in the as-machined state. However, considerably more testing experience is required before definitive conclusions on its suitability for electronic countermeasure systems and space TWT's can be made.

Acoustic holography as a metrological tool for characterizing medical ultrasound sources and fields

PubMed Central

Sapozhnikov, Oleg A.; Tsysar, Sergey A.; Khokhlova, Vera A.; Kreider, Wayne

2015-01-01

Acoustic holography is a powerful technique for characterizing ultrasound sources and the fields they radiate, with the ability to quantify source vibrations and reduce the number of required measurements. These capabilities are increasingly appealing for meeting measurement standards in medical ultrasound; however, associated uncertainties have not been investigated systematically. Here errors associated with holographic representations of a linear, continuous-wave ultrasound field are studied. To facilitate the analysis, error metrics are defined explicitly, and a detailed description of a holography formulation based on the Rayleigh integral is provided. Errors are evaluated both for simulations of a typical therapeutic ultrasound source and for physical experiments with three different ultrasound sources. Simulated experiments explore sampling errors introduced by the use of a finite number of measurements, geometric uncertainties in the actual positions of acquired measurements, and uncertainties in the properties of the propagation medium. Results demonstrate the theoretical feasibility of keeping errors less than about 1%. Typical errors in physical experiments were somewhat larger, on the order of a few percent; comparison with simulations provides specific guidelines for improving the experimental implementation to reduce these errors. Overall, results suggest that holography can be implemented successfully as a metrological tool with small, quantifiable errors. PMID:26428789

Relevant factors to consider prior to an investor-owned acquisition of a nonprofit healthcare entity.

PubMed

Ault, Kelvin; Childs, Brad; Wainright, Charles F; Young, Marilyn

2011-01-01

The purpose of this article is to explore the factors that affect the negotiations for an acquisition of a nonprofit system by an investor-owned entity. The recent economic downturn, accompanying credit crisis, and healthcare reform legislation will likely encourage and accelerate the pace of merger and acquisition (M&A) transactions between investor-owned entities and nonprofit hospitals. As many nonprofits are smaller, more financially vulnerable, and more limited in their access to capital than their investor-owned counterparts, nonprofits could be prime targets for investor-owned acquirers during the healthcare reform implementation period. In M&A transactions of this type, the investor-owned acquirer typically is motivated to pursue an acquisition when the deal promises an acceptable return on investment and decreased operating costs from economies of scale. Alternatively, the nonprofit target is typically seeking funding for upgrades to facilities and information technology systems as well as a continued commitment to charity care and managed-care contracting leverage. A successful acquisition of a nonprofit hospital by an investor-owned company requires a careful analysis of relevant tax, economic, and strategic factors prior to closing the deal. This article lists the most significant factors to consider in these deals and explains how these factors should influence the purchase price and postacquisition cash flow.

Reliable high-power diode lasers: thermo-mechanical fatigue aspects

NASA Astrophysics Data System (ADS)

Klumel, Genady; Gridish, Yaakov; Szafranek, Igor; Karni, Yoram

2006-02-01

High power water-cooled diode lasers are finding increasing demand in biomedical, cosmetic and industrial applications, where repetitive cw (continuous wave) and pulsed cw operation modes are required. When operating in such modes, the lasers experience numerous complete thermal cycles between "cold" heat sink temperature and the "hot" temperature typical of thermally equilibrated cw operation. It is clearly demonstrated that the main failure mechanism directly linked to repetitive cw operation is thermo-mechanical fatigue of the solder joints adjacent to the laser bars, especially when "soft" solders are used. Analyses of the bonding interfaces were carried out using scanning electron microscopy. It was observed that intermetallic compounds, formed already during the bonding process, lead to the solders fatigue both on the p- and n-side of the laser bar. Fatigue failure of solder joints in repetitive cw operation reduces useful lifetime of the stacks to hundreds hours, in comparison with more than 10,000 hours lifetime typically demonstrated in commonly adopted non-stop cw reliability testing programs. It is shown, that proper selection of package materials and solders, careful design of fatigue sensitive parts and burn-in screening in the hard pulse operation mode allow considerable increase of lifetime and reliability, without compromising the device efficiency, optical power density and compactness.

Psychotic and Bipolar Disorders: Bipolar Disorder.

PubMed

Holder, Sarah D

2017-04-01

Bipolar disorder is a severe chronic mental illness that affects a large number of individuals. This disorder is separated into two major types, bipolar I disorder, with mania and typically recurrent depression, and bipolar II disorder, with recurrent major depression and hypomania. Patients with bipolar disorder spend the majority of time experiencing depression, and this typically is the presenting symptom. Because outcomes are improved with earlier diagnosis and treatment, physicians should maintain a high index of suspicion for bipolar disorder. The most effective long-term treatments are lithium and valproic acid, although other drugs also are used. In addition to referral to a mental health subspecialist for initiation and management of drug treatment, patients with bipolar disorder should be provided with resources for psychotherapy. Several comorbidities commonly associated with bipolar disorder include other mental disorders, substance use disorders, migraine headaches, chronic pain, stroke, metabolic syndrome, and cardiovascular disease. Family physicians who care for patients with bipolar disorder should focus their efforts on prevention and management of comorbidities. These patients should be assessed continually for risk of suicide because they are at high risk and their suicide attempts tend to be successful. Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium.

V/STOL propulsion control analysis: Phase 2, task 5-9

NASA Technical Reports Server (NTRS)

1981-01-01

Typical V/STOL propulsion control requirements were derived for transition between vertical and horizontal flight using the General Electric RALS (Remote Augmented Lift System) concept. Steady-state operating requirements were defined for a typical Vertical-to-Horizontal transition and for a typical Horizontal-to-Vertical transition. Control mode requirements were established and multi-variable regulators developed for individual operating conditions. Proportional/Integral gain schedules were developed and were incorporated into a transition controller with capabilities for mode switching and manipulated variable reassignment. A non-linear component-level transient model of the engine was developed and utilized to provide a preliminary check-out of the controller logic. An inlet and nozzle effects model was developed for subsequent incorporation into the engine model and an aircraft model was developed for preliminary flight transition simulations. A condition monitoring development plan was developed and preliminary design requirements established. The Phase 1 long-range technology plan was refined and restructured toward the development of a real-time high fidelity transient model of a supersonic V/STOL propulsion system and controller for use in a piloted simulation program at NASA-Ames.

New metric for optimizing Continuous Loop Averaging Deconvolution (CLAD) sequences under the 1/f noise model

PubMed Central

Peng, Xian; Yuan, Han; Chen, Wufan; Ding, Lei

2017-01-01

Continuous loop averaging deconvolution (CLAD) is one of the proven methods for recovering transient auditory evoked potentials (AEPs) in rapid stimulation paradigms, which requires an elaborated stimulus sequence design to attenuate impacts from noise in data. The present study aimed to develop a new metric in gauging a CLAD sequence in terms of noise gain factor (NGF), which has been proposed previously but with less effectiveness in the presence of pink (1/f) noise. We derived the new metric by explicitly introducing the 1/f model into the proposed time-continuous sequence. We selected several representative CLAD sequences to test their noise property on typical EEG recordings, as well as on five real CLAD electroencephalogram (EEG) recordings to retrieve the middle latency responses. We also demonstrated the merit of the new metric in generating and quantifying optimized sequences using a classic genetic algorithm. The new metric shows evident improvements in measuring actual noise gains at different frequencies, and better performance than the original NGF in various aspects. The new metric is a generalized NGF measurement that can better quantify the performance of a CLAD sequence, and provide a more efficient mean of generating CLAD sequences via the incorporation with optimization algorithms. The present study can facilitate the specific application of CLAD paradigm with desired sequences in the clinic. PMID:28414803

A new continuous sliding mode control approach with actuator saturation for control of 2-DOF helicopter system.

PubMed

Sadala, S P; Patre, B M

2018-03-01

The 2-degree of freedom (DOF) helicopter system is a typical higher-order, multi-variable, nonlinear and strong coupled control system. The helicopter dynamics also includes parametric uncertainties and is subject to unknown external disturbances. Such complicated system requires designing a sophisticated control algorithm that can handle these difficulties. This paper presents a new robust control algorithm which is a combination of two continuous control techniques, composite nonlinear feedback (CNF) and super-twisting control (STC) methods. In the existing integral sliding mode (ISM) based CNF control law, the discontinuous term exhibits chattering which is not desirable for many practical applications. As the continuity of well known STC reduces chattering in the system, the proposed strategy is beneficial over the current ISM based CNF control law which has a discontinuous term. Two controllers with integral sliding surface are designed to control the position of the pitch and the yaw angles of the 2- DOF helicopter. The adequacy of this specific combination has been exhibited through general analysis, simulation and experimental results of 2-DOF helicopter setup. The acquired results demonstrate the good execution of the proposed controller regarding stabilization, following reference input without overshoot against actuator saturation and robustness concerning to the limited matched disturbances. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

Reconsidering Change and Continuity in Later Life: Toward an Innovation Theory of Successful Aging

ERIC Educational Resources Information Center

Nimrod, Galit; Kleiber, Douglas A.

2007-01-01

This article examines the patterns and meanings of innovation in the activities of a group of retirees with an eye toward understanding the place and value of innovation in the aging process. Starting with a consideration of continuity theory, as a perspective that simply describes typical patterns of activity, and activity theory that prescribes…

Recent developments in radiation field control technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, C.J.

1995-03-01

The U.S. nuclear power industry has been remarkably successful in reducing worker radiation exposures over the past ten years. There has been over a fourfold reduction in the person-rem incurred for each MW.year of electric power generated: from 1.8 in 1980, to only 0.39 person-rems in 1991 and 1992. Preliminary data for 1993 are even lower: approximately 0.37 person-rem.MW.year. Despite this substantial improvement, challenges for the industry remain. Individual exposure limits have been tightened in ICRP 60 and there will be increased requirements for special maintenance work as plants age, suggesting that vigorous efforts with be increased requirements for specialmore » maintenance work as plants age, suggesting that vigorous efforts will be required to meet the industry goals for 1995. Reducing out-of-core radiation fields offer the best chance of continuing the downward trend in exposures. To assist utilities select the most economic technology for their specific plants, EPRI has published a manual capturing worldwide operating experience with radiation-field control techniques (TR-100265). No one method will suffice, but implementing suitable combinations from this collection will enable utilities to achieve their exposure goals. Radiation reduction is generally cost-effective: outages are shorter, manpower requirements are reduced and work quality is improved. Despite the up front costs, the benefits over the following 1-3 years typically outweigh the expenses.« less

Insight into the Effects of Reinforcement Shape on Achieving Continuous Martensite Transformation in Phase Transforming Matrix Composites

NASA Astrophysics Data System (ADS)

Zhang, Xudong; Ren, Junqiang; Wang, Xiaofei; Zong, Hongxiang; Cui, Lishan; Ding, Xiangdong

2017-12-01

A continuous martensite transformation is indispensable for achieving large linear superelasticity and low modulus in phase transforming metal-based composites. However, determining how to accurately condition the residual martensite in a shape memory alloy matrix though the reinforcement shape to achieve continuous martensite transformation has been a challenge. Here, we take the finite element method to perform a comparative study of the effects of nanoinclusion shape on the interaction and martensite phase transformation in this new composite. Two typical samples are compared: one reinforced by metallic nanowires and the other by nanoparticles. We find that the residual martensite within the shape memory alloy matrix after a pretreatment can be tailored by the reinforcement shape. In particular, our results show that the shape memory alloy matrix can retain enough residual martensite phases to achieve continuous martensite transformation in the subsequent loading when the aspect ratio of nanoreinforcement is larger than 20. In contrast, the composites reinforced with spherical or low aspect ratio reinforcement show a typical nonlinear superelasticity as a result of a low stress transfer-induced discontinuous martensite transformation within the shape memory alloy matrix.

VISTA - A Constellation for Real Time Regional Imaging

NASA Astrophysics Data System (ADS)

Meerman, Max; Boland, Lee; da Silva Curiel, Alex; Sweeting, Martin, , Sir

2002-01-01

The role of satellites in medium and high-resolution reconnaissance of the Earth's surface has been well demonstrated in recent years through missions such as Landsat, SPOT, IKONOS, ImageSat and Quickbird. The market for such data products is well served and likely to become more competitive with further very-high-resolution missions. Whereas commercial markets have concentrated on enhancing resolution, the small satellite sector has concentrated on reducing the cost of data products, and the development of systems providing niche services. One such EO requirement that can be well met by smaller satellites is the need for higher temporal resolution, as this typically requires a large number of satellites to operate as a constellation - thus far financially impractical using conventional EO satellites. Surrey is currently engaged in building its first constellation that will provide daily global coverage at moderate resolution (32-metre GSD and 600km swath) in three spectral bands. Targeted at providing timely quick-look data products for disaster mitigation and monitoring, the constellation comprises 7 satellites in a single orbital plane. Each satellite has a wide swath so that successive satellites progressively cover the entire globe in a single day. The Vista constellation takes this concept a step further, and is proposed for applications requiring near-continuous surveillance of regional activity. By introducing a multiple plane constellation of small Earth observation satellites, it is possible to monitor continuously selected regions anywhere on the globe. The paper describes the system trades and outlines the scope of the performance that could be obtained from such a system. A cost model illustrates that the balance between launch and space segment costs must be reached by considering suitable replacement strategies, and that the system is highly sensitive to requirement creep. Finally, it is shown that the use of cost effective, small satellites leads to solutions previously thought to be financially beyond sensible reach.

28 CFR 61.5 - Typical classes of action.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... These classes are: actions normally requiring environmental impact statements (EIS), actions normally not requiring assessments or EIS, and actions normally requiring assessments but not necessarily EIS...) Actions normally requiring EIS. None, except as noted in the appendices to this part. (2) Actions normally...

Commercial mode-locked vertical external cavity surface emitting lasers

NASA Astrophysics Data System (ADS)

Head, C. Robin; Paboeuf, David; Ortega, Tiago; Lubeigt, Walter; Bialkowski, Bartlomiej; Lin, Jipeng; Hempler, Nils; Maker, Gareth T.; Malcolm, Graeme P. A.

2018-02-01

This paper presents the latest efforts in the development of commercial optically-pumped semiconductor disk lasers (SDLs) at M Squared Lasers. Two types of SDLs are currently being developed: an ultrafast system and a continuous wave single frequency system under the names of Dragonfly and Infinite, respectively. Both offer a compact, low-cost, easy-to-use and maintenance-free tool for a range of growing markets including nonlinear microscopy and quantum technology. To facilitate consumer uptake of the SDL technology, the performance specifications aim to closely match the currently employed systems. An extended Dragonfly system is being developed targeting the nonlinear microscopy market, which typically requires 1-W average power pulse trains with pulse durations below 200 fs. The pulse repetition frequency (PRF) of the commonly used laser systems, typically Titanium-sapphire lasers, is 80 MHz. This property is particularly challenging for mode-locked SDLs which tend to operate at GHz repetition rates, due to their short upper state carrier lifetime. Dragonfly has found a compromise at 200 MHz to balance mode-locking instabilities with a low PRF. In the ongoing development of Dragonfly, additional pulse compression and nonlinear spectral broadening stages are used to obtain pulse durations as short as 130 fs with an average power of 0.85 W, approaching the required performance. A variant of the Infinite system was adapted to provide a laser source suitable for the first stage of Sr atom cooling at 461 nm. Such a source requires average powers of approximately 1 W with a sub-MHz linewidth. As direct emission in the blue is not a viable approach at this stage, an SDL emitting at 922 nm followed by an M Squared Lasers SolTiS ECD-X doubler is currently under development. The SDL oscillator delivered >1 W of single frequency (RMS frequency noise <150kHz) light at 922 nm.

[Guideline implementation study on asthma: Results of a pragmatic implementation approach].

PubMed

Redaèlli, Marcus; Vollmar, Horst Christian; Simic, Dusan; Maly-Schürer, Cornelia; Löscher, Susanne; Koneczny, Nikolaus

2015-01-01

Knowledge transfer from theory to practice in healthcare systems poses a challenge worldwide. Typical examples include national disease management guidelines. The present study contributes towards improving implementation strategies for an asthma guideline. A guideline implementation strategy was examined in a four-armed, non-randomised, controlled intervention study with an additional control group. The study participants were general practitioners and paediatricians recruited from primary care quality circles. All study participants attended an interactive seminar on the evidence-based recommendations for patients with asthma. In addition, the participants were asked to choose among the following options: no further intervention, additional e-learning, training of their practice nurses, or e-learning and training of their practice nurses. The success of the intervention was measured by questionnaire (and the success rate expressed as a percentage). About one third of all participants (n=313) opted for the combination of an interactive seminar and a training of practice nurses; two third preferred the classic way of continuing medical education with an interactive seminar without a further intervention. Just 10 % of the physicians participated in e-learning. Independently of their choice for continuing medical education, all participants demonstrated an increase in knowledge about asthma and an improvement in the management of asthma. The physicians exhibited an average increase in both categories of about 10 % of the percentage values, compared to an increase of about 28 % among the practice nurses without continuing medical education. The physicians' free choice of the educative modules might be an integral part of successful implementation strategies. However, this will require a change of focus from general continuing medical education packages to a more individualised culture of continuing professional development in Germany. Copyright © 2015. Published by Elsevier GmbH.

Concept, Design, and Prototyping of XSAS: A High Power Extendable Solar Array for CubeSat Applications

NASA Technical Reports Server (NTRS)

Senatore, Patrick; Klesh, Andrew; Zurbuchen, Thomas H.; McKague, Darren; Cutler, James

2010-01-01

CubeSats have proven themselves as a reliable and cost-effective method to perform experiments in space, but they are highly constrained by their specifications and size. One such constraint is the average continuous power, about 5 W, which is available to the typical CubeSat. To improve this constraint, we have developed the eXtendable Solar Array System (XSAS), a deployable solar array prototype in a CubeSat package, which can provide an average 23 W of continuous power. The prototype served as a technology demonstrator for the high risk mechanisms needed to release, deploy, and control the solar array. Aside from this drastic power increase, it is in the integration of each mechanism, their application within the small CubeSat form-factor, and the inherent passive control benefit of the deployed geometry that make XSAS a novel design. In this paper, we discuss the requirements and design process for the XSAS system and mechanical prototype, and provide qualitative and quantitative results from numerical simulations and prototype tests. We also discuss future work, including an upcoming NASA zero-gravity flight campaign, to further improve on XSAS and prepare it for future launch opportunities.

Velocity locking and pulsed invasions of fragmented habitats with seasonal growth

NASA Astrophysics Data System (ADS)

Korolev, Kirill; Wang, Ching-Hao

From crystal growth to epidemics, spatial spreading is a common mechanism of change in nature. Typically, spreading results from two processes: growth and dispersal in ecology or chemical reactions and diffusion in physics. These two processes combine to produce a reaction-diffusion wave, an invasion front advancing at a constant velocity. We show that the properties of these waves are remarkably different depending whether space and time are continuous, as they are for a chemical reaction, or discrete, as they are for a pest invading a patchy habitat in seasonal climates. For discrete space and time, we report a new type of expansions with velocities that can lock into specific values and become insensitive to changes in dispersal and growth, i.e. the dependence of the velocity on model parameters exhibits plateaus or pauses. As a result, the evolution and response to perturbations in locked expansions can be markedly different compared to the expectations based on continuous models. The phenomenon of velocity locking requires cooperative growth and does not occur when per capita growth rate decline monotonically with population density. We obtain both numerical and analytical results describing highly non-analytic properties of locked expansions.

On discrete control of nonlinear systems with applications to robotics

NASA Technical Reports Server (NTRS)

Eslami, Mansour

1989-01-01

Much progress has been reported in the areas of modeling and control of nonlinear dynamic systems in a continuous-time framework. From implementation point of view, however, it is essential to study these nonlinear systems directly in a discrete setting that is amenable for interfacing with digital computers. But to develop discrete models and discrete controllers for a nonlinear system such as robot is a nontrivial task. Robot is also inherently a variable-inertia dynamic system involving additional complications. Not only the computer-oriented models of these systems must satisfy the usual requirements for such models, but these must also be compatible with the inherent capabilities of computers and must preserve the fundamental physical characteristics of continuous-time systems such as the conservation of energy and/or momentum. Preliminary issues regarding discrete systems in general and discrete models of a typical industrial robot that is developed with full consideration of the principle of conservation of energy are presented. Some research on the pertinent tactile information processing is reviewed. Finally, system control methods and how to integrate these issues in order to complete the task of discrete control of a robot manipulator are also reviewed.

Preventing Heart Attacks and Strokes: Increasing Awareness ...

EPA Pesticide Factsheets

Summary: Chronic cardiovascular disease imposes a significant health and economic burden on individuals and communities. Despite decades of improvement in cardiovascular mortality, cardiovascular disease and stroke remain the leading cause of death in the U.S. and disparities in health outcomes persist. Moreover, the continuous improvement in cardiovascular mortality typical of the last four decades has ended motivating new and innovative approaches to improve population health and wellbeing. Apart from continued focus on traditional risk factor modification such as identification and treatment of high blood pressure and cholesterol, cessation of smoking, and appropriate use of evidence-based pharmacological prevention measures and disease management, other factors should be considered such as increasing physical activity, dietary sodium reduction and modification of social and environmental determinants known to cause heart attacks and stroke and exacerbate vascular disease. Such an approach will require greater cooperation among public health, environmental health, the broader public and private healthcare delivery and payment systems, and federal agencies. To introduce this concept the U.S. EPA held a workshop in September 2016 bringing together representatives of local and state public health officials, the healthcare system, educators, data analytics, and federal partners (CMS, CDC, Dept. of State and EPA) for the purpose of exploring the idea of prom

New developments in psychosocial interventions for adults with unipolar depression.

PubMed

Lau, Mark A

2008-01-01

Depression treatment guidelines typically recommend cognitive behavioral therapy and/or interpersonal therapy for the acute treatment of mild-moderate depression. However, several new developments support an expanded role for psychotherapy in depression treatment. This article summarizes recent psychotherapy efficacy studies across the depression treatment continuum and the effectiveness of psychosocial interventions in community settings. New psychotherapies in the acute treatment of mild-moderate depression include emotion-focused therapy, self-system therapy, cognitive control training and positive psychotherapy. Furthermore, emerging evidence supports the use of psychotherapy for moderate-severe and treatment-resistant depression and for recurrent depression with a seasonal pattern. An important area of growth is the development and evaluation of continuation/maintenance treatments based on cognitive behavioral therapy and interpersonal therapy to reduce depressive relapse risk in recurrent and chronic depression. Finally, there is evidence supporting the effectiveness of stepped care, chronic disease management and collaborative care models in community settings. Emerging evidence supports an expanded role for the use of psychosocial interventions as acute and continuation/maintenance treatments for unipolar depression. Although further research is required to replicate these findings, a remaining challenge is to increase the availability of these treatments to the mental health consumer.

Efficient field testing for load rating railroad bridges

NASA Astrophysics Data System (ADS)

Schulz, Jeffrey L.; Brett C., Commander

1995-06-01

As the condition of our infrastructure continues to deteriorate, and the loads carried by our bridges continue to increase, an ever growing number of railroad and highway bridges require load limits. With safety and transportation costs at both ends of the spectrum. the need for accurate load rating is paramount. This paper describes a method that has been developed for efficient load testing and evaluation of short- and medium-span bridges. Through the use of a specially-designed structural testing system and efficient load test procedures, a typical bridge can be instrumented and tested at 64 points in less than one working day and with minimum impact on rail traffic. Various techniques are available to evaluate structural properties and obtain a realistic model. With field data, a simple finite element model is 'calibrated' and its accuracy is verified. Appropriate design and rating loads are applied to the resulting model and stress predictions are made. This technique has been performed on numerous structures to address specific problems and to provide accurate load ratings. The merits and limitations of this approach are discussed in the context of actual examples of both rail and highway bridges that were tested and evaluated.

A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma

NASA Astrophysics Data System (ADS)

Xia, Hui; Strachan, Briony C.; Gifford, Sean C.; Shevkoplyas, Sergey S.

2016-10-01

Leukocyte reduction of donated blood products substantially reduces the risk of a number of transfusion-related complications. Current ‘leukoreduction’ filters operate by trapping leukocytes within specialized filtration material, while allowing desired blood components to pass through. However, the continuous release of inflammatory cytokines from the retained leukocytes, as well as the potential for platelet activation and clogging, are significant drawbacks of conventional ‘dead end’ filtration. To address these limitations, here we demonstrate our newly-developed ‘controlled incremental filtration’ (CIF) approach to perform high-throughput microfluidic removal of leukocytes from platelet-rich plasma (PRP) in a continuous flow regime. Leukocytes are separated from platelets within the PRP by progressively syphoning clarified PRP away from the concentrated leukocyte flowstream. Filtrate PRP collected from an optimally-designed CIF device typically showed a ~1000-fold (i.e. 99.9%) reduction in leukocyte concentration, while recovering >80% of the original platelets, at volumetric throughputs of ~1 mL/min. These results suggest that the CIF approach will enable users in many fields to now apply the advantages of microfluidic devices to particle separation, even for applications requiring macroscale flowrates.

Reinforcement-Learning-Based Robust Controller Design for Continuous-Time Uncertain Nonlinear Systems Subject to Input Constraints.

PubMed

Liu, Derong; Yang, Xiong; Wang, Ding; Wei, Qinglai

2015-07-01

The design of stabilizing controller for uncertain nonlinear systems with control constraints is a challenging problem. The constrained-input coupled with the inability to identify accurately the uncertainties motivates the design of stabilizing controller based on reinforcement-learning (RL) methods. In this paper, a novel RL-based robust adaptive control algorithm is developed for a class of continuous-time uncertain nonlinear systems subject to input constraints. The robust control problem is converted to the constrained optimal control problem with appropriately selecting value functions for the nominal system. Distinct from typical action-critic dual networks employed in RL, only one critic neural network (NN) is constructed to derive the approximate optimal control. Meanwhile, unlike initial stabilizing control often indispensable in RL, there is no special requirement imposed on the initial control. By utilizing Lyapunov's direct method, the closed-loop optimal control system and the estimated weights of the critic NN are proved to be uniformly ultimately bounded. In addition, the derived approximate optimal control is verified to guarantee the uncertain nonlinear system to be stable in the sense of uniform ultimate boundedness. Two simulation examples are provided to illustrate the effectiveness and applicability of the present approach.

Steroids

MedlinePlus

... or sometimes with chemotherapy. Steroids are used for short-term symptom control although they may occasionally be continued ... even in lymphoma steroids are not typically a long-term cure for this tumor. HOW ARE STEROIDS TAKEN? ...

Lipid Panel

MedlinePlus

... Time and International Normalized Ratio (PT/INR) PSEN1 Quantitative Immunoglobulins Red Blood Cell (RBC) Antibody Identification Red ... typically includes a fasting lipid panel. Beyond that, research continues into the usefulness of other non-traditional ...

Continuing Professional Education for Licensed Accountants in Tennessee

ERIC Educational Resources Information Center

Lucas, Brian J.

2017-01-01

Accounting is a professional occupation that is continually evolving and requires a dedication to continuing education to meet the legal demands of new regulations and to maintain professional competency. Continuing Professional Education (CPE) is required by state boards for certified public accountants (CPA) to meet these requirements and to…

Discrimination Report: ESTCP UXO Discrimination Study, ESTCPProject #MM-0437

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gasperikova, Erika; Smith, J. Torquil; Morrison, H. Frank

2007-12-21

The FY06 Defense Appropriation contains funding for the 'Development of Advanced, Sophisticated, Discrimination Technologies for UXO Cleanup' in the Environmental Security Technology Certification Program. In 2003, the Defense Science Board observed: 'The problem is that instruments that can detect the buried UXOs also detect numerous scrap metal objects and other artifacts, which leads to an enormous amount of expensive digging. Typically 100 holes may be dug before a real UXO is unearthed! The Task Force assessment is that much of this wasteful digging can be eliminated by the use of more advanced technology instruments that exploit modern digital processing andmore » advanced multi-mode sensors to achieve an improved level of discrimination of scrap from UXOs.' Significant progress has been made in discrimination technology. To date, testing of these approaches has been primarily limited to test sites with only limited application at live sites. Acceptance of discrimination technologies requires demonstration of system capabilities at real UXO sites under real world conditions. Any attempt to declare detected anomalies to be harmless and requiring no further investigation require demonstration to regulators of not only individual technologies, but of an entire decision making process. This discrimination study was be the first phase in what is expected to be a continuing effort that will span several years.« less

Exploring model based engineering for large telescopes: getting started with descriptive models

NASA Astrophysics Data System (ADS)

Karban, R.; Zamparelli, M.; Bauvir, B.; Koehler, B.; Noethe, L.; Balestra, A.

2008-07-01

Large telescopes pose a continuous challenge to systems engineering due to their complexity in terms of requirements, operational modes, long duty lifetime, interfaces and number of components. A multitude of decisions must be taken throughout the life cycle of a new system, and a prime means of coping with complexity and uncertainty is using models as one decision aid. The potential of descriptive models based on the OMG Systems Modeling Language (OMG SysMLTM) is examined in different areas: building a comprehensive model serves as the basis for subsequent activities of soliciting and review for requirements, analysis and design alike. Furthermore a model is an effective communication instrument against misinterpretation pitfalls which are typical of cross disciplinary activities when using natural language only or free-format diagrams. Modeling the essential characteristics of the system, like interfaces, system structure and its behavior, are important system level issues which are addressed. Also shown is how to use a model as an analysis tool to describe the relationships among disturbances, opto-mechanical effects and control decisions and to refine the control use cases. Considerations on the scalability of the model structure and organization, its impact on the development process, the relation to document-centric structures, style and usage guidelines and the required tool chain are presented.

Requirement for serum in medium supplemented with insulin-transferrin-selenium for hydrodynamic cultivation of engineered cartilage.

PubMed

Yang, Yueh-Hsun; Barabino, Gilda A

2011-08-01

Achievement of viable engineered tissues through in vitro cultivation in bioreactor systems requires a thorough understanding of the complex interplay between hydrodynamic forces and biochemical cues such as serum. To this end, chondrocyte-seeded constructs were cultured under continuous fluid-induced shear forces with reduced serum content (0%-2%, v/v), which was partially or completely replaced by a potential substitute, insulin-transferrin-selenium, to minimize deleterious effects associated with the use of culture media containing high levels of serum (10%-20%). Low-serum cultures yielded constructs with similar biochemical properties to those cultivated with high-serum supplements, whereas the serum-free constructs exhibited poor cell proliferation, insufficient extracellular matrix production, and rapid degradation of and/or shear-induced damage to polyglycolic acid scaffolds. A fibrous outer capsule typically observed in hydrodynamic cultures and characterized by increased cell density and decreased (virtually none) glycosaminoglycan deposition was eliminated when serum concentration was equal to or <0.2% in the presence of hydrodynamic stimuli. Our findings suggest that serum is a requirement in insulin-transferrin-selenium-supplemented cultures in order for constructs to exhibit improved properties in response to hydrodynamic forces, and that mechanical and biochemical stimuli may synergistically modulate tissue properties and morphology through shear-responsive signals.

Comparing the use of open and closed questions for Web-based measures of the continued-influence effect.

PubMed

Connor Desai, Saoirse; Reimers, Stian

2018-06-25

Open-ended questions, in which participants write or type their responses, are used in many areas of the behavioral sciences. Although effective in the lab, they are relatively untested in online experiments, and the quality of responses is largely unexplored. Closed-ended questions are easier to use online because they generally require only single key- or mouse-press responses and are less cognitively demanding, but they can bias the responses. We compared the data quality obtained using open and closed response formats using the continued-influence effect (CIE), in which participants read a series of statements about an unfolding event, one of which is unambiguously corrected later. Participants typically continue to refer to the corrected misinformation when making inferential statements about the event. We implemented this basic procedure online (Exp. 1A, n = 78), comparing standard open-ended responses to an alternative procedure using closed-ended responses (Exp. 1B, n = 75). Finally, we replicated these findings in a larger preregistered study (Exps. 2A and 2B, n = 323). We observed the CIE in all conditions: Participants continued to refer to the misinformation following a correction, and their references to the target misinformation were broadly similar in number across open- and closed-ended questions. We found that participants' open-ended responses were relatively detailed (including an average of 75 characters for inference questions), and almost all responses attempted to address the question. The responses were faster, however, for closed-ended questions. Overall, we suggest that with caution it may be possible to use either method for gathering CIE data.

Face-to-face interference in typical and atypical development

PubMed Central

Riby, Deborah M; Doherty-Sneddon, Gwyneth; Whittle, Lisa

2012-01-01

Visual communication cues facilitate interpersonal communication. It is important that we look at faces to retrieve and subsequently process such cues. It is also important that we sometimes look away from faces as they increase cognitive load that may interfere with online processing. Indeed, when typically developing individuals hold face gaze it interferes with task completion. In this novel study we quantify face interference for the first time in Williams syndrome (WS) and Autism Spectrum Disorder (ASD). These disorders of development impact on cognition and social attention, but how do faces interfere with cognitive processing? Individuals developing typically as well as those with ASD (n = 19) and WS (n = 16) were recorded during a question and answer session that involved mathematics questions. In phase 1 gaze behaviour was not manipulated, but in phase 2 participants were required to maintain eye contact with the experimenter at all times. Looking at faces decreased task accuracy for individuals who were developing typically. Critically, the same pattern was seen in WS and ASD, whereby task performance decreased when participants were required to hold face gaze. The results show that looking at faces interferes with task performance in all groups. This finding requires the caveat that individuals with WS and ASD found it harder than individuals who were developing typically to maintain eye contact throughout the interaction. Individuals with ASD struggled to hold eye contact at all points of the interaction while those with WS found it especially difficult when thinking. PMID:22356183

13 CFR 124.603 - What reports regarding the continued business operations of former Participants does SBA require?

Code of Federal Regulations, 2010 CFR

2010-01-01

... continued business operations of former Participants does SBA require? 124.603 Section 124.603 Business... What reports regarding the continued business operations of former Participants does SBA require... continued business operations, contracts, and financial condition for a period of three years following the...

40 CFR 62.15205 - What minimum amount of monitoring data must I collect with my continuous emission monitoring...

Code of Federal Regulations, 2010 CFR

2010-07-01

... must I collect with my continuous emission monitoring systems and is this requirement enforceable? 62... with my continuous emission monitoring systems and is this requirement enforceable? (a) Where continuous emission monitoring systems are required, obtain 1-hour arithmetic averages. Make sure the...

40 CFR 62.15205 - What minimum amount of monitoring data must I collect with my continuous emission monitoring...

Code of Federal Regulations, 2011 CFR

2011-07-01

... must I collect with my continuous emission monitoring systems and is this requirement enforceable? 62... with my continuous emission monitoring systems and is this requirement enforceable? (a) Where continuous emission monitoring systems are required, obtain 1-hour arithmetic averages. Make sure the...

40 CFR 60.1735 - Am I exempt from any appendix B or appendix F requirements to evaluate continuous emission...

Code of Federal Regulations, 2011 CFR

2011-07-01

... appendix F requirements to evaluate continuous emission monitoring systems? 60.1735 Section 60.1735... systems? Yes, the accuracy tests for your sulfur dioxide continuous emission monitoring system require you to also evaluate your oxygen (or carbon dioxide) continuous emission monitoring system. Therefore...

40 CFR 63.7747 - How do I apply for alternative monitoring requirements for a continuous emissions monitoring system?

Code of Federal Regulations, 2011 CFR

2011-07-01

... monitoring requirements for a continuous emissions monitoring system? 63.7747 Section 63.7747 Protection of... apply for alternative monitoring requirements for a continuous emissions monitoring system? (a) You may... prevention technique, a description of the continuous monitoring system or method including appropriate...

40 CFR 60.1735 - Am I exempt from any appendix B or appendix F requirements to evaluate continuous emission...

Code of Federal Regulations, 2010 CFR

2010-07-01

... appendix F requirements to evaluate continuous emission monitoring systems? 60.1735 Section 60.1735... systems? Yes, the accuracy tests for your sulfur dioxide continuous emission monitoring system require you to also evaluate your oxygen (or carbon dioxide) continuous emission monitoring system. Therefore...

40 CFR 63.7747 - How do I apply for alternative monitoring requirements for a continuous emissions monitoring system?

Code of Federal Regulations, 2010 CFR

2010-07-01

... monitoring requirements for a continuous emissions monitoring system? 63.7747 Section 63.7747 Protection of... apply for alternative monitoring requirements for a continuous emissions monitoring system? (a) You may... prevention technique, a description of the continuous monitoring system or method including appropriate...

Charge efficiency of Ni/H2 cells during transfer orbit of Telstar 4 satellites

NASA Technical Reports Server (NTRS)

Fang, W. C.; Maurer, Dean W.; Vyas, B.; Thomas, M. N.

1994-01-01

The TELSTAR 4 communication satellites being manufactured by Martin Marietta Astro Space (Astro Space) for AT&T are three axis stabilized spacecraft scheduled to be launched on expendable vehicles such as the Atlas or Ariane rockets. Typically, these spacecraft consist of a box that holds the electronics and supports the antenna reflectors and the solar array wings. The wings and reflectors are folded against the sides of the box during launch and the spacecraft is spun for attitude control in that phase; they are then deployed after achieving the final orbit. The launch phase and transfer orbits required to achieve the final geosynchronous orbit typically take 4 to 5 days during which time the power required for command, telemetry, attitude control, heaters, etc., is provided by two 50 AH nickel hydrogen batteries augmented by the exposed outboard solar panels. In the past, this situation has presented no problem since there was a considerable excess of power available from the array. In the case of large high powered spacecraft such as TELSTAR 4, however, the design power levels in transfer orbit approach the time-averaged power available from the exposed surface area of the solar arrays, resulting in a very tight power margin. To compound the difficulty, the array output of the spinning spacecraft in transfer orbit is shaped like a full wave rectified sine function and provides very low charging rates to the batteries during portions of the rotation. In view of the typically low charging efficiency of alkaline nickel batteries at low rates, it was decided to measure the efficiency during a simulation of the TELSTAR 4 conditions at the expected power levels and temperatures on three nickel hydrogen cells of similar design. The unique feature of nickel hydrogen cells that makes the continuous measurement of efficiency possible is that hydrogen is one of the active materials and thus, cell pressure is a direct measure of the state of charge or available capacity. The pressure is measured with a calibrated strain gage mounted on the outside of the pressurized cell.

Feline leprosy due to Mycobacterium lepraemurium.

PubMed

O'Brien, Carolyn R; Malik, Richard; Globan, Maria; Reppas, George; McCowan, Christina; Fyfe, Janet A

2017-07-01

This paper, the second in a series of three on 'feline leprosy', provides a detailed description of disease referable to Mycobacterium lepraemurium, the most common cause of feline leprosy worldwide. Cases were sourced retrospectively and prospectively for this observational study, describing clinical, geographical and molecular microbiological data for cats definitively diagnosed with M lepraemurium infection. A total of 145 cases of feline leprosy were scrutinised; 114 'new' cases were sourced from the Victorian Infectious Diseases Reference Laboratory records, veterinary pathology laboratories or veterinarians, and 31 cases were derived from six published studies. Sixty-five cats were definitively diagnosed with M lepraemurium infection. Typically, cats were 1-3 years of age when first infected, with a male gender predilection. Affected cats were generally systemically well. All had outdoor access. Lesions tended to consist of one or more cutaneous/subcutaneous nodules, typically located on the head and/or forelimbs, possibly reflecting the most likely locations for a rodent bite as the site of inoculation for organisms. Nodules had the propensity to ulcerate at some stage in the clinical course. The cytological and histological picture varied from tuberculoid, with relatively low bacterial numbers, to lepromatous with moderate to high bacterial numbers. Treatment was varied, although most cats underwent surgical resection of lesions with adjunctive medical therapy, most often using a combination of oral clarithromycin and rifampicin. Prognosis for recovery was generally good, and in two cases there was spontaneous remission without the requirement for medical intervention. Untreated cats continued to enjoy an acceptable quality of life despite persistence of the disease, which extended locally but had no apparent tendency to disseminate to internal organs. M lepraemurium causes high bacterial index (lepromatous) or low bacterial index (tuberculoid) feline leprosy. The infection typically causes nodules of the skin and/or subcutis (which tend towards ulceration) on the head and/or forelimbs. The disease usually has an indolent clinical course and infected cats have a generally favourable response to therapeutic interventions, with rare cases undergoing spontaneous resolution. Genomic analysis may yield clues as to the environmental niche and culture requirements of this elusive organism. Prospective treatment trials and/or additional drug susceptibility testing in specialised systems would further inform treatment recommendations.

Optimal Cluster Mill Pass Scheduling With an Accurate and Rapid New Strip Crown Model

NASA Astrophysics Data System (ADS)

Malik, Arif S.; Grandhi, Ramana V.; Zipf, Mark E.

2007-05-01

Besides the requirement to roll coiled sheet at high levels of productivity, the optimal pass scheduling of cluster-type reversing cold mills presents the added challenge of assigning mill parameters that facilitate the best possible strip flatness. The pressures of intense global competition, and the requirements for increasingly thinner, higher quality specialty sheet products that are more difficult to roll, continue to force metal producers to commission innovative flatness-control technologies. This means that during the on-line computerized set-up of rolling mills, the mathematical model should not only determine the minimum total number of passes and maximum rolling speed, it should simultaneously optimize the pass-schedule so that desired flatness is assured, either by manual or automated means. In many cases today, however, on-line prediction of strip crown and corresponding flatness for the complex cluster-type rolling mills is typically addressed either by trial and error, by approximate deflection models for equivalent vertical roll-stacks, or by non-physical pattern recognition style models. The abundance of the aforementioned methods is largely due to the complexity of cluster-type mill configurations and the lack of deflection models with sufficient accuracy and speed for on-line use. Without adequate assignment of the pass-schedule set-up parameters, it may be difficult or impossible to achieve the required strip flatness. In this paper, we demonstrate optimization of cluster mill pass-schedules using a new accurate and rapid strip crown model. This pass-schedule optimization includes computations of the predicted strip thickness profile to validate mathematical constraints. In contrast to many of the existing methods for on-line prediction of strip crown and flatness on cluster mills, the demonstrated method requires minimal prior tuning and no extensive training with collected mill data. To rapidly and accurately solve the multi-contact problem and predict the strip crown, a new customized semi-analytical modeling technique that couples the Finite Element Method (FEM) with classical solid mechanics was developed to model the deflection of the rolls and strip while under load. The technique employed offers several important advantages over traditional methods to calculate strip crown, including continuity of elastic foundations, non-iterative solution when using predetermined foundation moduli, continuous third-order displacement fields, simple stress-field determination, and a comparatively faster solution time.

ERP correlates of object recognition memory in Down syndrome: Do active and passive tasks measure the same thing?

PubMed

Van Hoogmoed, A H; Nadel, L; Spanò, G; Edgin, J O

2016-02-01

Event related potentials (ERPs) can help to determine the cognitive and neural processes underlying memory functions and are often used to study populations with severe memory impairment. In healthy adults, memory is typically assessed with active tasks, while in patient studies passive memory paradigms are generally used. In this study we examined whether active and passive continuous object recognition tasks measure the same underlying memory process in typically developing (TD) adults and in individuals with Down syndrome (DS), a population with known hippocampal impairment. We further explored how ERPs in these tasks relate to behavioral measures of memory. Data-driven analysis techniques revealed large differences in old-new effects in the active versus passive task in TD adults, but no difference between these tasks in DS. The group with DS required additional processing in the active task in comparison to the TD group in two ways. First, the old-new effect started 150 ms later. Second, more repetitions were required to show the old-new effect. In the group with DS, performance on a behavioral measure of object-location memory was related to ERP measures across both tasks. In total, our results suggest that active and passive ERP memory measures do not differ in DS and likely reflect the use of implicit memory, but not explicit processing, on both tasks. Our findings highlight the need for a greater understanding of the comparison between active and passive ERP paradigms before they are inferred to measure similar functions across populations (e.g., infants or intellectual disability). Copyright © 2016 Elsevier Ltd. All rights reserved.

Electronic Flash In Data Acquisition

NASA Astrophysics Data System (ADS)

Miller, C. E.

1982-02-01

Photographic acquisition of data often may be simplified, or the data quality improved upon by employing electronic flash sources with traditional equipment or techniques. The relatively short flash duration compared to movie camera shutters, or to the long integration time of video camera provides improved spatial resolution through blur reduction, particularly important as image movement becomes a significant fraction of film format dimension. Greater accuracy typically is achieved in velocity and acceleration determinations by using a stroboscopic light source rather than a movie camera frame-rate control as a time standard. Electrical efficiency often is an important advantage of electronic flash sources since almost any necessary light level for exposure may be produced, yet the source typically is "off" most of the time. Various synchronization techniques greatly expand the precise control of exposure. Biomechanical and sports equipment studies may involve velocities up to 200 feet-per-second, and often will have associated very rapid actions of interest. The need for brief exposures increases H.s one "ZOOMS in on the action." In golf, for example, the swing may be examined using 100 microsecond (Us) flashes at rates of 60 or 120 flashes-per-second (FPS). Accurate determination of linear and rotational velocity of the ball requires 10 Us flashes at 500-1,000 FPS, while sub-Us flashes at 20,000-50,000 FPS are required to resolve the interaction of the ball and the club, head. Some seldom. used techniques involving streak photography are described, with enhanced results obtained by combining strobe with the usual continuous light source. The combination of strobe and a fast electro-mechanical shutter is considered for Us photography under daylight conditions.

Cell culture chamber with gas supply for prolonged recording of human neuronal cells on microelectrode array.

PubMed

Kreutzer, Joose; Ylä-Outinen, Laura; Mäki, Antti-Juhana; Ristola, Mervi; Narkilahti, Susanna; Kallio, Pasi

2017-03-15

Typically, live cell analyses are performed outside an incubator in an ambient air, where the lack of sufficient CO 2 supply results in a fast change of pH and the high evaporation causes concentration drifts in the culture medium. That limits the experiment time for tens of minutes. In many applications, e.g. in neurotoxicity studies, a prolonged measurement of extracellular activity is, however, essential. We demonstrate a simple cell culture chamber that enables stable culture conditions during prolonged extracellular recordings on a microelectrode array (MEA) outside an incubator. The proposed chamber consists of a gas permeable silicone structure that enables gas transfer into the chamber. We show that the culture chamber supports the growth of the human embryonic stem cell (hESC)-derived neurons both inside and outside an incubator. The structure provides very low evaporation, stable pH and osmolarity, and maintains strong signaling of hESC-derived neuronal networks over three-day MEA experiments. Existing systems are typically complex including continuous perfusion of medium or relatively large amount of gas to supply. The proposed chamber requires only a supply of very low flow rate (1.5ml/min) of non-humidified 5% CO 2 gas. Utilizing dry gas supply makes the proposed chamber simple to use. Using the proposed culture structure on top of MEA, we can maintain hESC-derived neural networks over three days outside an incubator. Technically, the structure requires very low flow rate of dry gas supporting, however, low evaporation and maintaining the pH of the culture. Copyright © 2017 Elsevier B.V. All rights reserved.

Fluid-Structure Interaction and Structural Analyses using a Comprehensive Mitral Valve Model with 3D Chordal Structure

PubMed Central

Toma, Milan; Einstein, Daniel R.; Bloodworth, Charles H.; Cochran, Richard P.; Yoganathan, Ajit P.; Kunzelman, Karyn S.

2016-01-01

Over the years, three-dimensional models of the mitral valve have generally been organized around a simplified anatomy. Leaflets have been typically modeled as membranes, tethered to discrete chordae typically modeled as one-dimensional, non-linear cables. Yet, recent, high-resolution medical images have revealed that there is no clear boundary between the chordae and the leaflets. In fact, the mitral valve has been revealed to be more of a webbed structure whose architecture is continuous with the chordae and their extensions into the leaflets. Such detailed images can serve as the basis of anatomically accurate, subject-specific models, wherein the entire valve is modeled with solid elements that more faithfully represent the chordae, the leaflets, and the transition between the two. These models have the potential to enhance our understanding of mitral valve mechanics, and to re-examine the role of the mitral valve chordae, which heretofore have been considered to be “invisible” to the fluid and to be of secondary importance to the leaflets. However, these new models also require a rethinking of modeling assumptions. In this study, we examine the conventional practice of loading the leaflets only and not the chordae in order to study the structural response of the mitral valve apparatus. Specifically, we demonstrate that fully resolved 3D models of the mitral valve require a fluid-structure interaction analysis to correctly load the valve even in the case of quasi-static mechanics. While a fluid-structure interaction mode is still more computationally expensive than a structural-only model, we also show that advances in GPU computing have made such models tractable. PMID:27342229

Fluid-structure interaction and structural analyses using a comprehensive mitral valve model with 3D chordal structure.

PubMed

Toma, Milan; Einstein, Daniel R; Bloodworth, Charles H; Cochran, Richard P; Yoganathan, Ajit P; Kunzelman, Karyn S

2017-04-01

Over the years, three-dimensional models of the mitral valve have generally been organized around a simplified anatomy. Leaflets have been typically modeled as membranes, tethered to discrete chordae typically modeled as one-dimensional, non-linear cables. Yet, recent, high-resolution medical images have revealed that there is no clear boundary between the chordae and the leaflets. In fact, the mitral valve has been revealed to be more of a webbed structure whose architecture is continuous with the chordae and their extensions into the leaflets. Such detailed images can serve as the basis of anatomically accurate, subject-specific models, wherein the entire valve is modeled with solid elements that more faithfully represent the chordae, the leaflets, and the transition between the two. These models have the potential to enhance our understanding of mitral valve mechanics and to re-examine the role of the mitral valve chordae, which heretofore have been considered to be 'invisible' to the fluid and to be of secondary importance to the leaflets. However, these new models also require a rethinking of modeling assumptions. In this study, we examine the conventional practice of loading the leaflets only and not the chordae in order to study the structural response of the mitral valve apparatus. Specifically, we demonstrate that fully resolved 3D models of the mitral valve require a fluid-structure interaction analysis to correctly load the valve even in the case of quasi-static mechanics. While a fluid-structure interaction mode is still more computationally expensive than a structural-only model, we also show that advances in GPU computing have made such models tractable. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

R2R--software to speed the depiction of aesthetic consensus RNA secondary structures.

PubMed

Weinberg, Zasha; Breaker, Ronald R

2011-01-04

With continuing identification of novel structured noncoding RNAs, there is an increasing need to create schematic diagrams showing the consensus features of these molecules. RNA structural diagrams are typically made either with general-purpose drawing programs like Adobe Illustrator, or with automated or interactive programs specific to RNA. Unfortunately, the use of applications like Illustrator is extremely time consuming, while existing RNA-specific programs produce figures that are useful, but usually not of the same aesthetic quality as those produced at great cost in Illustrator. Additionally, most existing RNA-specific applications are designed for drawing single RNA molecules, not consensus diagrams. We created R2R, a computer program that facilitates the generation of aesthetic and readable drawings of RNA consensus diagrams in a fraction of the time required with general-purpose drawing programs. Since the inference of a consensus RNA structure typically requires a multiple-sequence alignment, the R2R user annotates the alignment with commands directing the layout and annotation of the RNA. R2R creates SVG or PDF output that can be imported into Adobe Illustrator, Inkscape or CorelDRAW. R2R can be used to create consensus sequence and secondary structure models for novel RNA structures or to revise models when new representatives for known RNA classes become available. Although R2R does not currently have a graphical user interface, it has proven useful in our efforts to create 100 schematic models of distinct noncoding RNA classes. R2R makes it possible to obtain high-quality drawings of the consensus sequence and structural models of many diverse RNA structures with a more practical amount of effort. R2R software is available at http://breaker.research.yale.edu/R2R and as an Additional file.

Rapid determination of 226Ra in environmental samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maxwell, Sherrod L.; Culligan, Brian K.

A new rapid method for the determination of {sup 228}Ra in natural water samples has been developed at the SRNL/EBL (Savannah River National Lab/ Environmental Bioassay Laboratory) that can be used for emergency response or routine samples. While gamma spectrometry can be employed with sufficient detection limits to determine {sup 228}Ra in solid samples (via {sup 228}Ac) , radiochemical methods that employ gas flow proportional counting techniques typically provide lower MDA (Minimal Detectable Activity) levels for the determination of {sup 228}Ra in water samples. Most radiochemical methods for {sup 228}Ra collect and purify {sup 228}Ra and allow for {sup 228}Acmore » daughter ingrowth for ~36 hours. In this new SRNL/EBL approach, {sup 228}Ac is collected and purified from the water sample without waiting to eliminate this delay. The sample preparation requires only about 4 hours so that {sup 228}Ra assay results on water samples can be achieved in < 6 hours. The method uses a rapid calcium carbonate precipitation enhanced with a small amount of phosphate added to enhance chemical yields (typically >90%), followed by rapid cation exchange removal of calcium. Lead, bismuth, uranium, thorium and protactinium isotopes are also removed by the cation exchange separation. {sup 228}Ac is eluted from the cation resin directly onto a DGA Resin cartridge attached to the bottom of the cation column to purify {sup 228}Ac. DGA Resin also removes lead and bismuth isotopes, along with Sr isotopes and {sup 90}Y. La is used to determine {sup 228}Ac chemical yield via ICP-MS, but {sup 133}Ba can also be used instead if ICP-MS assay is not available. Unlike some older methods, no lead or strontium holdback carriers or continual readjustment of sample pH is required.« less

Detailed Microstructural Characterization and Restoration Mechanisms of Duplex and Superduplex Stainless Steel Friction-Stir-Welded Joints

NASA Astrophysics Data System (ADS)

Santos, T. F. A.; Torres, E. A.; Lippold, J. C.; Ramirez, A. J.

2016-12-01

Duplex stainless steels are successfully used in a wide variety of applications in areas such as the food industry, petrochemical installations, and sea water desalination plants, where high corrosion resistance and high mechanical strength are required. However, during fusion welding operations, there can be changes to the favorable microstructure of these materials that compromise their performance. Friction stir welding with a non-consumable pin enables welded joints to be obtained in the solid state, which avoids typical problems associated with solidification of the molten pool, such as segregation of alloying elements and the formation of solidification and liquefaction cracks. In the case of superduplex stainless steels, use of the technique can avoid unbalanced proportions of ferrite and austenite, formation of deleterious second phases, or growth of ferritic grains in the heat-affected zone. Consolidated joints with full penetration were obtained for 6-mm-thick plates of UNS S32101 and S32205 duplex stainless steels, and S32750 and S32760 superduplex steels. The welding heat cycles employed avoided the conditions required for formation of deleterious phases, except in the case of the welded joint of the S32760 steel, where SEM images indicated the formation of secondary phases, as corroborated by decreased mechanical performance. Analysis using EBSD and transmission electron microscopy revealed continuous dynamic recrystallization by the formation of cellular arrays of dislocations in the ferrite and discontinuous dynamic recrystallization in the austenite. Microtexture evaluation indicated the presence of fibers typical of shear in the thermomechanically affected zone. These fibers were not obviously present in the stir zone, probably due to the intensity of microstructural reformulation to which this region was subjected.

Superoleophobic yet Superhydrophilic surfaces for Continuous Liquid-Liquid Separation

DTIC Science & Technology

2011-12-08

cases, such membranes are oleophilic, i.e., Young’s contact angle (12) with oil !oil < 90º. Hydrophobic (or superhydrophobic (10, 11, 13)) and...continuous liquid-liquid separation. Final Report, Anish Tuteja, University of Michigan 3 hydrophobic (or superhydrophobic ) membranes are easily...in air typically loses its oleophobicity under water and vice-versa (17, 18). Despite numerous natural superhydrophobic surfaces (19, 20), due to

40 CFR 63.9920 - What are my continuous monitoring requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Continuous Compliance Requirements § 63.9920 What are my continuous monitoring requirements? For each wet scrubber subject to the operating limits for pressure drop and scrubber water flow rates in § 63.9890(b...

40 CFR 63.9920 - What are my continuous monitoring requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Continuous Compliance Requirements § 63.9920 What are my continuous monitoring requirements? For each wet scrubber subject to the operating limits for pressure drop and scrubber water flow rates in § 63.9890(b...

Internal Cargo Integration

NASA Technical Reports Server (NTRS)

Hart, Angela

2006-01-01

A description of internal cargo integration is presented. The topics include: 1) Typical Cargo for Launch/Disposal; 2) Cargo Delivery Requirements; 3) Cargo Return Requirements; and 4) Vehicle On-Orbit Stay Time.

40 CFR Table 12 to Subpart Wwww of... - Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Continuous Lamination Lines and Continuous Casting Lines Complying With a Lbs/Ton Organic HAP Emissions Limit... Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Lbs... with a lbs/ton organic HAP emissions limit for continuous lamination lines and continuous casting lines...

40 CFR 63.9636 - How do I demonstrate continuous compliance with the operation and maintenance requirements that...

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with the operation and maintenance requirements that apply to me? 63.9636 Section 63.9636....9636 How do I demonstrate continuous compliance with the operation and maintenance requirements that... demonstrate continuous compliance with the operation and maintenance requirements in § 63.9600(b) by...

Instabilities of geared couplings: Theory and practice

NASA Technical Reports Server (NTRS)

Kirk, R. G.; Mondy, R. E.; Murphy, R. C.

1982-01-01

The use of couplings for high speed turbocompressors or pumps is essential to transmit power from the driver. Typical couplings are either of the lubricated gear or dry diaphragm type design. Gear couplings have been the standard design for many years and recent advances in power and speed requirements have pushed the standard design criteria to the limit. Recent test stand and field data on continuous lube gear type couplings have forced a closer examination of design tolerances and concepts to avoid operational instabilities. Two types of mechanical instabilities are reviewed in this paper: (1) entrapped fluid, and (2) gear mesh instability resulting in spacer throw-out onset. Test stand results of these types of instabilities and other directly related problems are presented together with criteria for proper coupling design to avoid these conditions. An additional test case discussed shows the importance of proper material selection and processing and what can happen to an otherwise good design.

Thermomechanical Property Data Base Developed for Ceramic Fibers

NASA Technical Reports Server (NTRS)

1996-01-01

A key to the successful application of metal and ceramic composite materials in advanced propulsion and power systems is the judicious selection of continuous-length fiber reinforcement. Appropriate fibers can provide these composites with the required thermomechanical performance. To aid in this selection, researchers at the NASA Lewis Research Center, using in-house state-of-the-art test facilities, developed an extensive data base of the deformation and fracture properties of commercial and developmental ceramic fibers at elevated temperatures. Lewis' experimental focus was primarily on fiber compositions based on silicon carbide or alumina because of their oxidation resistance, low density, and high modulus. Test approaches typically included tensile and flexural measurements on single fibers or on multifilament tow fibers in controlled environments of air or argon at temperatures from 800 to 1400 C. Some fiber specimens were pretreated at composite fabrication temperatures to simulate in situ composite conditions, whereas others were precoated with potential interphase and matrix materials.

An Ontology-based Architecture for Integration of Clinical Trials Management Applications

PubMed Central

Shankar, Ravi D.; Martins, Susana B.; O’Connor, Martin; Parrish, David B.; Das, Amar K.

2007-01-01

Management of complex clinical trials involves coordinated-use of a myriad of software applications by trial personnel. The applications typically use distinct knowledge representations and generate enormous amount of information during the course of a trial. It becomes vital that the applications exchange trial semantics in order for efficient management of the trials and subsequent analysis of clinical trial data. Existing model-based frameworks do not address the requirements of semantic integration of heterogeneous applications. We have built an ontology-based architecture to support interoperation of clinical trial software applications. Central to our approach is a suite of clinical trial ontologies, which we call Epoch, that define the vocabulary and semantics necessary to represent information on clinical trials. We are continuing to demonstrate and validate our approach with different clinical trials management applications and with growing number of clinical trials. PMID:18693919

Variable-temperature cryogenic trap for the separation of gas mixtures

NASA Technical Reports Server (NTRS)

Des Marais, D. J.

1978-01-01

The paper describes a continuous variable-temperature U-shaped cold trap which can both purify vacuum-line combustion products for subsequent stable isotopic analysis and isolate the methane and ethane constituents of natural gases. The canister containing the trap is submerged in liquid nitrogen, and, as the gas cools, the gas mixture components condense sequentially according to their relative vapor pressures. After the about 12 min required for the bottom of the trap to reach the liquid-nitrogen temperature, passage of electric current through the resistance wire wrapped around the tubing covering the U-trap permits distillation of successive gas components at optimal temperatures. Data on the separation achieved for two mixtures, the first being typical vacuum-line combustion products of geochemical samples such as rocks and the second being natural gas, are presented, and the thermal behavior and power consumption are reported.

The manipulator tool state classification based on inertia forces analysis

NASA Astrophysics Data System (ADS)

Gierlak, Piotr

2018-07-01

In this article, we discuss the detection of damage to the cutting tool used in robotised light mechanical processing. Continuous monitoring of the state of the tool mounted in the tool holder of the robot is required due to the necessity to save time. The tool is a brush with ceramic fibres used for surface grinding. A typical example of damage to the brush is the breaking of fibres, resulting in a tool imbalance and vibrations at a high rotational speed, e.g. during grinding. This also results in a limited operating surface of the tool and a decrease in the efficiency of processing. While an imbalanced tool is spinning, fictitious forces occur that carry the information regarding the balance of the tool. The forces can be measured using a force sensor located in the end-effector of the robot allowing the assessment of the damage to the brush in an automatized way, devoid of any operator.

Fractional watt Vuillemier cryogenic refrigerator program engineering notebook. Volume 1: Thermal analysis

NASA Technical Reports Server (NTRS)

Miller, W. S.

1974-01-01

The cryogenic refrigerator thermal design calculations establish design approach and basic sizing of the machine's elements. After the basic design is defined, effort concentrates on matching the thermodynamic design with that of the heat transfer devices (heat exchangers and regenerators). Typically, the heat transfer device configurations and volumes are adjusted to improve their heat transfer and pressure drop characteristics. These adjustments imply that changes be made to the active displaced volumes, compensating for the influence of the heat transfer devices on the thermodynamic processes of the working fluid. Then, once the active volumes are changed, the heat transfer devices require adjustment to account for the variations in flows, pressure levels, and heat loads. This iterative process is continued until the thermodynamic cycle parameters match the design of the heat transfer devices. By examing several matched designs, a near-optimum refrigerator is selected.

Application of a scattered-light radiometric power meter.

PubMed

Caron, James N; DiComo, Gregory P; Ting, Antonio C; Fischer, Richard P

2011-04-01

The power measurement of high-power continuous-wave laser beams typically calls for the use of water-cooled thermopile power meters. Large thermopile meters have slow response times that can prove insufficient to conduct certain tests, such as determining the influence of atmospheric turbulence on transmitted beam power. To achieve faster response times, we calibrated a digital camera to measure the power level as the optical beam is projected onto a white surface. This scattered-light radiometric power meter saves the expense of purchasing a large area power meter and the required water cooling. In addition, the system can report the power distribution, changes in the position, and the spot size of the beam. This paper presents the theory of the scattered-light radiometric power meter and demonstrates its use during a field test at a 2.2 km optical range. © 2011 American Institute of Physics

Resonances and bound states in the continuum on periodic arrays of slightly noncircular cylinders

NASA Astrophysics Data System (ADS)

Hu, Zhen; Lu, Ya Yan

2018-02-01

Optical bound states in the continuum (BICs), especially those on periodic structures, have interesting properties and potentially important applications. Existing theoretical and numerical studies for optical BICs are mostly for idealized structures with simple and perfect geometric features, such as circular holes, rectangular cylinders and spheres. Since small distortions are always present in actual fabricated structures, we perform a high accuracy numerical study for BICs and resonances on a simple periodic structure with small distortions, i.e., periodic arrays of slightly noncircular cylinders. Our numerical results confirm that symmetries are important not only for the so-called symmetry-protected BICs, but also for the majority of propagating BICs which do not have a symmetry mismatch with the outgoing radiation waves. Typically, the BICs continue to exist if the small distortions keep the relevant symmetries, and they become resonant modes with finite quality factors if the small distortions break a required symmetry.

Evaluation of the Long-Term Stability and Temperature Coefficient of Dew-Point Hygrometers

NASA Astrophysics Data System (ADS)

Benyon, R.; Vicente, T.; Hernández, P.; De Rivas, L.; Conde, F.

2012-09-01

The continuous quest for improved specifications of optical dew-point hygrometers has raised customer expectations on the performance of these devices. In the absence of a long calibration history, users with a limited prior experience in the measurement of humidity, place reliance on manufacturer specifications to estimate long-term stability. While this might be reasonable in the case of measurement of electrical quantities, in humidity it can lead to optimistic estimations of uncertainty. This article reports a study of the long-term stability of some hygrometers and the analysis of their performance as monitored through regular calibration. The results of the investigations provide some typical, realistic uncertainties associated with the long-term stability of instruments used in calibration and testing laboratories. Together, these uncertainties can help in establishing initial contributions in uncertainty budgets, as well as in setting the minimum calibration requirements, based on the evaluation of dominant influence quantities.

Unconventional energy resources: 2015 review. Shale gas and liquids

USGS Publications Warehouse

Fishman, Neil S.; Bowker, Kent; Cander, Harris; Cardott, Brian; Charette, Marc; Chew, Kenneth; Chidsey, Thomas; Dubiel, Russell F.; Egenhoff, Sven O.; Enomoto, Catherine B.; Hammes, Ursula; Harrison, William; Jiang, Shu; LeFever, Julie A.; McCracken, Jock; Nordeng, Stephen; Nyahay, Richard; Sonnenberg, Stephen; Vanden Berg, Michael; ,

2015-01-01

Introduction As the source rocks from which petroleum is generated, organic-rich shales have always been considered an important component of petroleum systems. Over the last few years, it has been realized that in some mudrocks, sufficient hydrocarbons remain in place to allow for commercial development, although advanced drilling and completion technology is typically required to access hydrocarbons from these reservoirs. Tight oil reservoirs (also referred to as continuous oil accumulations) contain hydrocarbons migrated from source rocks that are geologically/stratigraphically interbedded with or occur immediately overlying/underlying them. Migration is minimal in charging these tight oil accumulations (Gaswirth and Marra 2014). Companies around the world are now successfully exploiting organic-rich shales and tight rocks for contained hydrocarbons, and the search for these types of unconventional petroleum reservoirs is growing. Unconventional reservoirs range in geologic age from Ordovician to Tertiary (Silverman et al. 2005; EIA 2013a). 

Development of processes for the production of low cost silicon dendritic web for solar cells

NASA Technical Reports Server (NTRS)

Duncan, C. S.; Seidensticker, R. G.; Mchugh, J. P.; Hopkins, R. H.; Skutch, M. E.; Driggers, J. M.; Hill, F. E.

1980-01-01

High area output rates and continuous, automated growth are two key technical requirements for the growth of low-cost silicon ribbons for solar cells. By means of computer-aided furnace design, silicon dendritic web output rates as high as 27 sq cm/min have been achieved, a value in excess of that projected to meet a $0.50 per peak watt solar array manufacturing cost. The feasibility of simultaneous web growth while the melt is replenished with pelletized silicon has also been demonstrated. This step is an important precursor to the development of an automated growth system. Solar cells made on the replenished material were just as efficient as devices fabricated on typical webs grown without replenishment. Moreover, web cells made on a less-refined, pelletized polycrystalline silicon synthesized by the Battelle process yielded efficiencies up to 13% (AM1).

Microfluidic Controlled Conformal Coating of Particles

NASA Astrophysics Data System (ADS)

Tsai, Scott; Wexler, Jason; Wan, Jiandi; Stone, Howard

2011-11-01

Coating flows are an important class of fluid mechanics problems. Typically a substrate is coated with a moving continuous film, but it is also possible to consider coating of discrete objects. In particular, in applications involving coating of particles that are useful in drug delivery, the coatings act as drug-carrying vehicles, while in cell therapy a thin polymeric coating is required to protect the cells from the host's immune system. Although many functional capabilities have been developed for lab-on-a-chip devices, a technique for coating has not been demonstrated. We present a microfluidic platform developed to coat micron-size spheres with a thin aqueous layer by magnetically pulling the particles from the aqueous phase to the non-aqueous phase in a co-flow. Coating thickness can be adjusted by the average fluid speed and the number of beads encapsulated inside a single coat is tuned by the ratio of magnetic to interfacial forces acting on the beads.

A convenient and accurate parallel Input/Output USB device for E-Prime.

PubMed

Canto, Rosario; Bufalari, Ilaria; D'Ausilio, Alessandro

2011-03-01

Psychological and neurophysiological experiments require the accurate control of timing and synchrony for Input/Output signals. For instance, a typical Event-Related Potential (ERP) study requires an extremely accurate synchronization of stimulus delivery with recordings. This is typically done via computer software such as E-Prime, and fast communications are typically assured by the Parallel Port (PP). However, the PP is an old and disappearing technology that, for example, is no longer available on portable computers. Here we propose a convenient USB device enabling parallel I/O capabilities. We tested this device against the PP on both a desktop and a laptop machine in different stress tests. Our data demonstrate the accuracy of our system, which suggests that it may be a good substitute for the PP with E-Prime.

Safety Evaluation of Discontinuing Late-Night Flash Operations at Signalized Intersections : Summary Report

DOT National Transportation Integrated Search

2013-08-01

During late-night flash (LNF) mode (from late night to early morning hours), traffic signals flash yellow for one road (typically, the major road), requiring caution but no stopping, and flash red for the other road (typically, the minor road), requi...

A public health training center experience: professional continuing education at schools of public health.

PubMed

Potter, Margaret A; Fertman, Carl I; Eggleston, Molly M; Holtzhauer, Frank; Pearsol, Joanne

2008-01-01

The Public Health Training Center (PHTC) national program was first established at accredited schools of public health in 2000. The PHTC program used the US Health Resources and Services Administration's grants to build workforce development programs, attracting schools as training providers and the workforce as training clients. This article is a reflection on the experience of two schools, whose partnership supported one of the PHTCs, for the purpose of opening a conversation about the future of continuing education throughout schools and degree programs of public health. This partnership, the Pennsylvania & Ohio Public Health Training Center (POPHTC), concentrated its funding on more intensive training of public healthcare workers through a relatively narrow inventory of courses that were delivered typically in-person rather than by distance-learning technologies. This approach responded to the assessed needs and preferences of the POPHTC's workforce population. POPHTC's experience may not be typical among the PHTCs nationally, but the collective experience of all PHTCs is instructive to schools of public health as they work to meet an increasing demand for continuing education from the public health workforce.

Lifetime evaluation of large format CMOS mixed signal infrared devices

NASA Astrophysics Data System (ADS)

Linder, A.; Glines, Eddie

2015-09-01

New large scale foundry processes continue to produce reliable products. These new large scale devices continue to use industry best practice to screen for failure mechanisms and validate their long lifetime. The Failure-in-Time analysis in conjunction with foundry qualification information can be used to evaluate large format device lifetimes. This analysis is a helpful tool when zero failure life tests are typical. The reliability of the device is estimated by applying the failure rate to the use conditions. JEDEC publications continue to be the industry accepted methods.

40 CFR 52.2573 - General requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false General requirements. 52.2573 Section 52.2573 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2573 General requirements. (a...

40 CFR 52.2573 - General requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 5 2013-07-01 2013-07-01 false General requirements. 52.2573 Section 52.2573 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2573 General requirements. (a...

40 CFR 52.2573 - General requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false General requirements. 52.2573 Section 52.2573 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2573 General requirements. (a...

40 CFR 52.2573 - General requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 4 2010-07-01 2010-07-01 false General requirements. 52.2573 Section 52.2573 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2573 General requirements. (a...

40 CFR 52.2573 - General requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 5 2012-07-01 2012-07-01 false General requirements. 52.2573 Section 52.2573 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Wisconsin § 52.2573 General requirements. (a...

Station-Keeping Requirements for Astronomical Imaging with Constellations of Free-Flying Collectors

NASA Technical Reports Server (NTRS)

Allen, Ronald J.

2004-01-01

The requirements on station-keeping for constellations of free-flying collectors coupled as (future) imaging arrays in space for astrophysics applications are discussed. The typical knowledge precision required in the plane of the array depends on the angular size of the targets of interest; it is generally at a level of tens of centimeters for typical stellar targets, becoming of order centimeters only for the widest attainable fields of view. In the "piston" direction, perpendicular to the array, the typical knowledge precision required depends on the bandwidth of the signal, and is at a level of tens of wavelengths for narrow approx. 1% signal bands, becoming of order one wavelength only for the broadest bandwidths expected to be useful. The significance of this result is that, at this level of precision, it may be possible to provide the necessary knowledge of array geometry without the use of signal photons, thereby allowing observations of faint targets. "Closure-phase" imaging is a technique which has been very successfully applied to surmount instabilities owing to equipment and to the atmosphere, and which appears to be directly applicable to space imaging arrays where station-keeping drifts play the same role as (slow) atmospheric and equipment instabilities.

40 CFR 60.1765 - What additional requirements must I meet for the operation of my continuous emission monitoring...

Code of Federal Regulations, 2011 CFR

2011-07-01

... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? 60.1765 Section 60.1765 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values...

40 CFR 60.1765 - What additional requirements must I meet for the operation of my continuous emission monitoring...

Code of Federal Regulations, 2010 CFR

2010-07-01

... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? 60.1765 Section 60.1765 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values...

NASA Schedule Management Handbook

NASA Technical Reports Server (NTRS)

2011-01-01

The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.

Information System Requirements Determination: Factors Impeding Stakeholders from Reaching Common Understandings and Agreements on Requirements

ERIC Educational Resources Information Center

Gissel, Richard L.

2010-01-01

Information system implementations require developers to first know what they must create and then determine how best to create it. The requirements determination phase of the system development life cycle typically determines what functions a system must perform and how well it must accomplish required functions. Implementation success depends on…

Correlation of simulation/finite element analysis to the separation of intrinsically magnetic spores and red blood cells using a microfluidic magnetic deposition system.

PubMed

Sun, Jianxin; Moore, Lee; Xue, Wei; Kim, James; Zborowski, Maciej; Chalmers, Jeffrey J

2018-05-01

Magnetic separation of cells has been, and continues to be, widely used in a variety of applications, ranging from healthcare diagnostics to detection of food contamination. Typically, these technologies require cells labeled with antibody magnetic particle conjugate and a high magnetic energy gradient created in the flow containing the labeled cells (i.e., a column packed with magnetically inducible material), or dense packing of magnetic particles next to the flow cell. Such designs, while creating high magnetic energy gradients, are not amenable to easy, highly detailed, mathematic characterization. Our laboratories have been characterizing and developing analysis and separation technology that can be used on intrinsically magnetic cells or spores which are typically orders of magnitude weaker than typically immunomagnetically labeled cells. One such separation system is magnetic deposition microscopy (MDM) which not only separates cells, but deposits them in specific locations on slides for further microscopic analysis. In this study, the MDM system has been further characterized, using finite element and computational fluid mechanics software, and separation performance predicted, using a model which combines: 1) the distribution of the intrinsic magnetophoretic mobility of the cells (spores); 2) the fluid flow within the separation device; and 3) accurate maps of the values of the magnetic field (max 2.27 T), and magnetic energy gradient (max of 4.41 T 2 /mm) within the system. Guided by this model, experimental studies indicated that greater than 95% of the intrinsically magnetic Bacillus spores can be separated with the MDM system. Further, this model allows analysis of cell trajectories which can assist in the design of higher throughput systems. © 2018 Wiley Periodicals, Inc.

Medical physics aspects of cancer care in the Asia Pacific region

PubMed Central

Kron, T; Cheung, KY; Dai, J; Ravindran, P; Soejoko, D; Inamura, K; Song, JY; Bold, L; Srivastava, R; Rodriguez, L; Wong, TJ; Kumara, A; Lee, CC; Krisanachinda, A; Nguyen, XC; Ng, KH

2008-01-01

Medical physics plays an essential role in modern medicine. This is particularly evident in cancer care where medical physicists are involved in radiotherapy treatment planning and quality assurance as well as in imaging and radiation protection. Due to the large variety of tasks and interests, medical physics is often subdivided into specialties such as radiology, nuclear medicine and radiation oncology medical physics. However, even within their specialty, the role of radiation oncology medical physicists (ROMPs) is diverse and varies between different societies. Therefore, a questionnaire was sent to leading medical physicists in most countries/areas in the Asia/Pacific region to determine the education, role and status of medical physicists. Answers were received from 17 countries/areas representing nearly 2800 radiation oncology medical physicists. There was general agreement that medical physicists should have both academic (typically at MSc level) and clinical (typically at least 2 years) training. ROMPs spent most of their time working in radiotherapy treatment planning (average 17 hours per week); however radiation protection and engineering tasks were also common. Typically, only physicists in large centres are involved in research and teaching. Most respondents thought that the workload of physicists was high, with more than 500 patients per year per physicist, less than one ROMP per two oncologists being the norm, and on average, one megavoltage treatment unit per medical physicist. There was also a clear indication of increased complexity of technology in the region with many countries/areas reporting to have installed helical tomotherapy, IMRT (Intensity Modulated Radiation Therapy), IGRT (Image Guided Radiation Therapy), Gamma-knife and Cyber-knife units. This and the continued workload from brachytherapy will require growing expertise and numbers in the medical physics workforce. Addressing these needs will be an important challenge for the future. PMID:21611001

Detecting peroxiredoxin hyperoxidation by one-dimensional isoelectric focusing.

PubMed

Cao, Zhenbo; Bulleid, Neil J

The activity of typical 2-cys peroxiredoxin (Prxs) can be regulated by hyperoxidation with a consequent loss of redox activity. Here we developed a simple assay to monitor the level of hyperoxidation of different typical 2-cys prxs simultaneously. This assay only requires standard equipment and can compare different samples on the same gel. It requires much less time than conventional 2D gels and gives more information than Western blotting with an antibody specific for hyperoxidized peroxiredoxin. This method could also be used to monitor protein modification with a charge difference such as phosphorylation.

Frequency-Modulated Continuous-Wave Fm-Cw Radar for Evaluation of Refractory Structures Used in Glass Manufacturing Furnaces

NASA Astrophysics Data System (ADS)

Carroll, B.; Kharkovsky, S.; Zoughi, R.; Limmer, R.

2009-03-01

A frequency-modulated continuous-wave (FM-CW) handheld radar operating in the frequency range of 8-18 GHz, resulting in a relatively fine range resolution was designed and constructed for on-site inspection of refractory structure thickness. This paper presents the design of the radar and the results of measurements conducted on typical refractory furnace structures assembled in the laboratory.

Experiences and recommendations in deploying a real-time, water quality monitoring system

NASA Astrophysics Data System (ADS)

O'Flynn, B.; Regan, F.; Lawlor, A.; Wallace, J.; Torres, J.; O'Mathuna, C.

2010-12-01

Monitoring of water quality at a river basin level to meet the requirements of the Water Framework Directive (WFD) using conventional sampling and laboratory-based techniques poses a significant financial burden. Wireless sensing systems offer the potential to reduce these costs considerably, as well as provide more useful, continuous monitoring capabilities by giving an accurate idea of the changing environmental and water quality in real time. It is unlikely that the traditional spot/grab sampling will provide a reasonable estimate of the true maximum and/or mean concentration for a particular physicochemical variable in a water body with marked temporal variability. When persistent fluctuations occur, it is likely only to be detected through continuous measurements, which have the capability of detecting sporadic peaks of concentration. Thus, in situ sensors capable of continuous sampling of parameters required under the WFD would therefore provide more up-to-date information, cut monitoring costs and provide better coverage representing long-term trends in fluctuations of pollutant concentrations. DEPLOY is a technology demonstration project, which began planning and station selection and design in August 2008 aiming to show how state-of-the-art technology could be implemented for cost-effective, continuous and real-time monitoring of a river catchment. The DEPLOY project is seen as an important building block in the realization of a wide area autonomous network of sensors capable of monitoring the spatial and temporal distribution of important water quality and environmental target parameters. The demonstration sites chosen are based in the River Lee, which flows through Ireland's second largest city, Cork, and were designed to include monitoring stations in five zones considered typical of significant river systems--these monitor water quality parameters such as pH, temperature, depth, conductivity, turbidity and dissolved oxygen. Over one million data points have been collected since the multi-sensor system was deployed in May 2009. Extreme meteorological events have occurred during the period of deployment and the collection of real-time water quality data as well as the knowledge, experience and recommendations for future deployments are discussed.

Water and Proppant Requirements and Water Production Associated with Undiscovered Petroleum in the Bakken and Three Forks Formations, North Dakota and Montana, USA

NASA Astrophysics Data System (ADS)

Haines, S. S.; Varela, B. A.; Thamke, J.; Hawkins, S. J.; Gianoutsos, N. J.; Tennyson, M. E.

2017-12-01

Water is used for several stages of oil and gas production, in particular for hydraulic fracturing that is typically used during production of petroleum from low-permeability shales and other rock types (referred to as "continuous" petroleum accumulations). Proppant, often sand, is also consumed during hydraulic fracturing. Water is then produced from the reservoir along with the oil and gas, representing either a disposal consideration or a possible source of water for further petroleum development or other purposes. The U.S. Geological Survey (USGS) has developed an approach for regional-scale estimation of these water and proppant quantities in order to provide an improved understanding of possible impacts and to help with planning and decision-making. Using the new methodology, the USGS has conducted a quantitative assessment of water and proppant requirements, and water production volumes, associated with associated with possible future production of undiscovered petroleum resources in the Bakken and Three Forks Formations, Williston Basin, USA. This water and proppant assessment builds directly from the 2013 USGS petroleum assessment for the Bakken and Three Forks Formations. USGS petroleum assessments incorporate all available geologic and petroleum production information, and include the definition of assessment units (AUs) that specify the geographic regions and geologic formations for the assessment. The 2013 petroleum assessment included 5 continuous AUs for the Bakken Formation and one continuous AU for the Three Forks Formation. The assessment inputs are defined probabilistically, and a Monte Carlo approach provides outputs that include uncertainty bounds. We can summarize the assessment outputs with the mean values of the associated distributions. The mean estimated total volume of water for well drilling and cement for all six continuous AUs is 5.9 billion gallons, and the mean estimated volume of water for hydraulic fracturing for all AUs is 164.3 billion gallons. The mean estimated quantity of proppant for hydraulic fracturing is 101.3 million tons. Summing over all of the AUs, the mean estimated total flowback water volume is 9.9 billion gallons and the mean estimated total produced water is 414.5 billion gallons.

Propulsion issues, options and trades

NASA Technical Reports Server (NTRS)

Forsythe, Doug J.

1986-01-01

Several different types of propulsion concepts are discussed: pulsed fission; continuous nuclear fission; chemical; and chemical boost with advanced nuclear fission. Some of the key characteristics of each type are provided, and typical concepts of each are shown.

75 FR 32099 - Enterprise Duty To Serve Underserved Markets

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

.... Delinquencies and defaults on chattel loans typically exceed rates on mortgage loans.\\31\\ \\29\\ See Ronald A... incentive to continue to repay their loans, which may lead to increased delinquencies and defaults.'' Origen...

Developmental milestones record - 9 months

MedlinePlus

... Feeds self with fingers Throws or shakes objects SENSORY AND COGNITIVE SKILLS The 9-month-old typically: Babbles Has separation anxiety and may cling to parents Is developing depth perception Understands that objects continue to exist, even when ...

Using Concentration Curves to Assess Organization-Specific Relationships between Surgeon Volumes and Outcomes.

PubMed

Kanter, Michael H; Huang, Yii-Chieh; Kally, Zina; Gordon, Margo A; Meltzer, Charles

2018-06-01

A well-documented association exists between higher surgeon volumes and better outcomes for many procedures, but surgeons may be reluctant to change practice patterns without objective, credible, and near real-time data on their performance. In addition, published thresholds for procedure volumes may be biased or perceived as arbitrary; typical reports compare surgeons grouped into discrete procedure volume categories, even though the volume-outcomes relationship is likely continuous. The concentration curves methodology, which has been used to analyze whether health outcomes vary with socioeconomic status, was adapted to explore the association between procedure volume and outcomes as a continuous relationship so that data for all surgeons within a health care organization could be included. Using widely available software and requiring minimal analytic expertise, this approach plots cumulative percentages of two variables of interest against each other and assesses the characteristics of the resulting curve. Organization-specific relationships between surgeon volumes and outcomes were examined for three example types of procedures: uncomplicated hysterectomies, infant circumcisions, and total thyroidectomies. The concentration index was used to assess whether outcomes were equally distributed unrelated to volumes. For all three procedures, the concentration curve methodology identified associations between surgeon procedure volumes and selected outcomes that were specific to the organization. The concentration indices confirmed the higher prevalence of examined outcomes among low-volume surgeons. The curves supported organizational discussions about surgical quality. Concentration curves require minimal resources to identify organization- and procedure-specific relationships between surgeon procedure volumes and outcomes and can support quality improvement. Copyright © 2018 The Joint Commission. Published by Elsevier Inc. All rights reserved.

Attention, Working Memory, and Grammaticality Judgment in Typical Young Adults

ERIC Educational Resources Information Center

Smith, Pamela A.

2011-01-01

Purpose: To examine resource allocation and sentence processing, this study examined the effects of auditory distraction on grammaticality judgment (GJ) of sentences varied by semantics (reversibility) and short-term memory requirements. Method: Experiment 1: Typical young adult females (N = 60) completed a whole-sentence GJ task in distraction…

18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or elements...

18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or elements...

18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or elements...

18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or elements...

18 CFR 707.8 - Typical classes of action requiring similar treatment under NEPA.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Typical classes of... Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) Water... submittal of regional water resources management plans (comprehensive, coordinated, joint plans or elements...

This image, looking south, shows a typical corridor in the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

This image, looking south, shows a typical corridor in the laboratory area of the building, where numerous pipes were required to carry the various utilities needed for procedure and safety equipment - Department of Energy, Mound Facility, Electronics Laboratory Building (E Building), One Mound Road, Miamisburg, Montgomery County, OH

40 CFR 75.21 - Quality assurance and quality control requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Quality assurance and quality control... PROGRAMS (CONTINUED) CONTINUOUS EMISSION MONITORING Operation and Maintenance Requirements § 75.21 Quality assurance and quality control requirements. (a) Continuous emission monitoring systems. The owner or...

48 CFR 301.606-73 - Requirements for continuous learning maintenance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Requirements for continuous learning maintenance. 301.606-73 Section 301.606-73 Federal Acquisition Regulations System HEALTH..., and Responsibilities 301.606-73 Requirements for continuous learning maintenance. Designated Project...

48 CFR 301.606-73 - Requirements for continuous learning maintenance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Requirements for continuous learning maintenance. 301.606-73 Section 301.606-73 Federal Acquisition Regulations System HEALTH..., and Responsibilities 301.606-73 Requirements for continuous learning maintenance. Designated Project...

Phase plate technology for laser marking of magnetic discs

DOEpatents

Neuman, Bill; Honig, John; Hackel, Lloyd; Dane, C. Brent; Dixit, Shamasundar

1998-01-01

An advanced design for a phase plate enables the distribution of spots in arbitrarily shaped patterns with very high uniformity and with a continuously or near-continuously varying phase pattern. A continuous phase pattern eliminates large phase jumps typically expected in a grating that provides arbitrary shapes. Large phase jumps increase scattered light outside of the desired pattern, reduce efficiency and can make the grating difficult to manufacture. When manufacturing capabilities preclude producing a fully continuous grating, the present design can be easily adapted to minimize manufacturing errors and maintain high efficiencies. This continuous grating is significantly more efficient than previously described Dammann gratings, offers much more flexibility in generating spot patterns and is easier to manufacture and replicate than a multi-level phase grating.

Decongestion: Diuretics and other therapies for hospitalized heart failure.

PubMed

Vazir, Ali; Cowie, Martin R

2016-04-01

Acute heart failure (AHF) is a potentially life-threatening clinical syndrome, usually requiring hospital admission. Often the syndrome is characterized by congestion, and is associated with long hospital admissions and high risk of readmission and further healthcare expenditure. Despite a limited evidence-base, diuretics remain the first-line treatment for congestion. Loop diuretics are typically the first-line diuretic strategy with some evidence that initial treatment with continuous infusion or boluses of high-dose loop diuretic is superior to an initial lower dose strategy. In patients who have impaired responsiveness to diuretics, the addition of an oral thiazide or thiazide-like diuretic to induce sequential nephron blockade can be beneficial. The use of intravenous low-dose dopamine is no longer supported in heart failure patients with preserved systolic blood pressure and its use to assist diuresis in patients with low systolic blood pressures requires further study. Mechanical ultrafiltration has been used to treat patients with heart failure and fluid retention, but the evidence-base is not robust, and its place in clinical practice is yet to be established. Several novel pharmacological agents remain under investigation. Copyright © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

A physical and economic model of the nuclear fuel cycle

NASA Astrophysics Data System (ADS)

Schneider, Erich Alfred

A model of the nuclear fuel cycle that is suitable for use in strategic planning and economic forecasting is presented. The model, to be made available as a stand-alone software package, requires only a small set of fuel cycle and reactor specific input parameters. Critical design criteria include ease of use by nonspecialists, suppression of errors to within a range dictated by unit cost uncertainties, and limitation of runtime to under one minute on a typical desktop computer. Collision probability approximations to the neutron transport equation that lead to a computationally efficient decoupling of the spatial and energy variables are presented and implemented. The energy dependent flux, governed by coupled integral equations, is treated by multigroup or continuous thermalization methods. The model's output includes a comprehensive nuclear materials flowchart that begins with ore requirements, calculates the buildup of 24 actinides as well as fission products, and concludes with spent fuel or reprocessed material composition. The costs, direct and hidden, of the fuel cycle under study are also computed. In addition to direct disposal and plutonium recycling strategies in current use, the model addresses hypothetical cycles. These include cycles chosen for minor actinide burning and for their low weapons-usable content.

Shape Biased Low Power Spin Dependent Tunneling Magnetic Field Sensors

NASA Astrophysics Data System (ADS)

Tondra, Mark; Qian, Zhenghong; Wang, Dexin; Nordman, Cathy; Anderson, John

2001-10-01

Spin Dependent Tunneling (SDT) devices are leading candidates for inclusion in a number of Unattended Ground Sensor applications. Continued progress at NVE has pushed their performance to 1OOs of pT I rt. Hz 1 Hz. However, these sensors were designed to use an applied field from an on-chip coil to create an appropriate magnetic sensing configuration. The power required to generate this field (^100mW) is significantly greater than the power budget (^lmW) for a magnetic sensor in an Unattended Ground Sensor (UGS) application. Consequently, a new approach to creating an ideal sensing environment is required. One approach being used at NVE is "shape biasing." This means that the physical layout of the SDT sensing elements is such that the magnetization of the sensing film is correct even when no biasing field is applied. Sensors have been fabricated using this technique and show reasonable promise for UGS applications. Some performance trade-offs exist. The power is easily tinder 1 MW, but the sensitivity is typically lower by a factor of 10. This talk will discuss some of the design details of these sensors as well as their expected ultimate performance.

Burning Mouth Syndrome: A Review of the Etiopathologic Factors and Management.

PubMed

Vellappally, Sajith

2016-02-01

Burning mouth syndrome (BMS) is characterized by pain in the mouth with or with no inflammatory signs and no specific lesions. Synonyms found in literature include glossodynia, oral dysesthesia, glossopyrosis, glossalgia, stomatopyrosis, and stomatodynia. Burning mouth syndrome generally presents as a triad: Mouth pain, alteration in taste, and altered salivation, in the absence of visible mucosal lesions in the mouth. The syndrome generally manifests spontaneously, and the discomfort is typically of a continuous nature but increases in intensity during evening and at night. The etiopathogenesis seems to be complex and in a large number of patients probably involves interactions among local, systemic, and/or psychogenic factors. The differential diagnosis requires the exclusion of oral mucosal lesions or blood test alterations that can produce burning mouth sensation. Management is always based on the etiological agents involved. If burning persists after local or systemic conditions are treated, then treatment is aimed at controlling neuropathic symptoms. Treatment of BMS is still unsatisfactory, and there is no definitive cure. As a result, a multidisciplinary approach is required to bring the condition under better control. The aim of this review was to discuss several aspects of BMS, update current knowledge, and provide guidelines for patient management.

Nanofibre production in spiders without electric charge.

PubMed

Joel, Anna-Christin; Baumgartner, Werner

2017-06-15

Technical nanofibre production is linked to high voltage, because nanofibres are typically produced by electrospinning. In contrast, spiders have evolved a way to produce nanofibres without high voltage. These spiders are called cribellate spiders and produce nanofibres within their capture thread production. It is suggested that their nanofibres become frictionally charged when brushed over a continuous area on the calamistrum, a comb-like structure at the metatarsus of the fourth leg. Although there are indications that electrostatic charges are involved in the formation of the thread structure, final proof is missing. We proposed three requirements to validate this hypothesis: (1) the removal of any charge during or after thread production has an influence on the structure of the thread; (2) the characteristic structure of the thread can be regenerated by charging; and (3) the thread is attracted to or repelled from differently charged objects. None of these three requirements were proven true. Furthermore, mathematical calculations reveal that even at low charges, the calculated structural assembly of the thread does not match the observed reality. Electrostatic forces are therefore not involved in the production of cribellate capture threads. © 2017. Published by The Company of Biologists Ltd.

Precision reconstruction of manufactured free-form components

NASA Astrophysics Data System (ADS)

Ristic, Mihailo; Brujic, Djordje; Ainsworth, Iain

2000-03-01

Manufacturing needs in many industries, especially the aerospace and the automotive, involve CAD remodeling of manufactured free-form parts using NURBS. This is typically performed as part of 'first article inspection' or 'closing the design loop.' The reconstructed model must satisfy requirements such as accuracy, compatibility with the original CAD model and adherence to various constraints. The paper outlines a methodology for realizing this task. Efficiency and quality of the results are achieved by utilizing the nominal CAD model. It is argued that measurement and remodeling steps are equally important. We explain how the measurement was optimized in terms of accuracy, point distribution and measuring speed using a CMM. Remodeling steps include registration, data segmentation, parameterization and surface fitting. Enforcement of constraints such as continuity was performed as part of the surface fitting process. It was found necessary that the relevant algorithms are able to perform in the presence of measurement noise, while making no special assumptions about regularity of data distribution. In order to deal with real life situations, a number of supporting functions for geometric modeling were required and these are described. The presented methodology was applied using real aeroengine parts and the experimental results are presented.

A Fast Evaluation Method for Energy Building Consumption Based on the Design of Experiments

NASA Astrophysics Data System (ADS)

Belahya, Hocine; Boubekri, Abdelghani; Kriker, Abdelouahed

2017-08-01

Building sector is one of the effective consumer energy by 42% in Algeria. The need for energy has continued to grow, in inordinate way, due to lack of legislation on energy performance in this large consumer sector. Another reason is the simultaneous change of users’ requirements to maintain their comfort, especially summer in dry lands and parts of southern Algeria, where the town of Ouargla presents a typical example which leads to a large amount of electricity consumption through the use of air conditioning. In order to achieve a high performance envelope of the building, an optimization of major parameters building envelope is required, using design of experiments (DOE), can determine the most effective parameters and eliminate the less importance. The study building is often complex and time consuming due to the large number of parameters to consider. This study focuses on reducing the computing time and determines the major parameters of building energy consumption, such as area of building, factor shape, orientation, ration walls to windows …etc to make some proposal models in order to minimize the seasonal energy consumption due to air conditioning needs.

Operational risk assessment.

PubMed

McKim, Vicky L

2017-06-01

In the world of risk management, which encompasses the business continuity disciplines, many types of risk require evaluation. Financial risk is most often the primary focus, followed by product and market risks. Another critical area, which typically lacks a thorough review or may be overlooked, is operational risk. This category encompasses many risk exposure types including those around building structures and systems, environmental issues, nature, neighbours, clients, regulatory compliance, network, data security and so on. At times, insurance carriers will assess internal hazards, but seldom do these assessments include more than a cursory look at other types of operational risk. In heavily regulated environments, risk assessments are required but may not always include thorough assessments of operational exposures. Vulnerabilities may linger or go unnoticed, only to become the catalyst for a business disruption at a later time, some of which are so severe that business recovery becomes nearly impossible. Businesses may suffer loss of clients as the result of a prolonged disruption of services. Comprehensive operational risk assessments can assist in identifying such vulnerabilities, exposures and threats so that the risk can be minimised or removed. This paper lays out how an assessment of this type can be successfully conducted.

Developmental Dyscalculia and Automatic Magnitudes Processing: Investigating Interference Effects between Area and Perimeter.

PubMed

Eidlin-Levy, Hili; Rubinsten, Orly

2017-01-01

The relationship between numbers and other magnitudes has been extensively investigated in the scientific literature. Here, the objectives were to examine whether two continuous magnitudes, area and perimeter, are automatically processed and whether adults with developmental dyscalculia (DD) are deficient in their ability to automatically process one or both of these magnitudes. Fifty-seven students (30 with DD and 27 with typical development) performed a novel Stroop-like task requiring estimation of one aspect (area or perimeter) while ignoring the other. In order to track possible changes in automaticity due to practice, we measured performance after initial and continuous exposure to stimuli. Similar to previous findings, current results show a significant group × congruency interaction, evident beyond exposure level or magnitude type. That is, the DD group systematically showed larger Stroop effects. However, analysis of each exposure period showed that during initial exposure to stimuli the DD group showed larger Stroop effects in the perimeter and not in the area task. In contrast, during continuous exposure to stimuli no triple interaction was evident. It is concluded that both magnitudes are automatically processed. Nevertheless, individuals with DD are deficient in inhibiting irrelevant magnitude information in general and, specifically, struggle to inhibit salient area information after initial exposure to a perimeter comparison task. Accordingly, the findings support the assumption that DD involves a deficiency in multiple cognitive components, which include domain-specific and domain-general cognitive functions.

Developmental Dyscalculia and Automatic Magnitudes Processing: Investigating Interference Effects between Area and Perimeter

PubMed Central

Eidlin-Levy, Hili; Rubinsten, Orly

2017-01-01

The relationship between numbers and other magnitudes has been extensively investigated in the scientific literature. Here, the objectives were to examine whether two continuous magnitudes, area and perimeter, are automatically processed and whether adults with developmental dyscalculia (DD) are deficient in their ability to automatically process one or both of these magnitudes. Fifty-seven students (30 with DD and 27 with typical development) performed a novel Stroop-like task requiring estimation of one aspect (area or perimeter) while ignoring the other. In order to track possible changes in automaticity due to practice, we measured performance after initial and continuous exposure to stimuli. Similar to previous findings, current results show a significant group × congruency interaction, evident beyond exposure level or magnitude type. That is, the DD group systematically showed larger Stroop effects. However, analysis of each exposure period showed that during initial exposure to stimuli the DD group showed larger Stroop effects in the perimeter and not in the area task. In contrast, during continuous exposure to stimuli no triple interaction was evident. It is concluded that both magnitudes are automatically processed. Nevertheless, individuals with DD are deficient in inhibiting irrelevant magnitude information in general and, specifically, struggle to inhibit salient area information after initial exposure to a perimeter comparison task. Accordingly, the findings support the assumption that DD involves a deficiency in multiple cognitive components, which include domain-specific and domain-general cognitive functions. PMID:29312066

A View on Future Building System Modeling and Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wetter, Michael

This chapter presents what a future environment for building system modeling and simulation may look like. As buildings continue to require increased performance and better comfort, their energy and control systems are becoming more integrated and complex. We therefore focus in this chapter on the modeling, simulation and analysis of building energy and control systems. Such systems can be classified as heterogeneous systems because they involve multiple domains, such as thermodynamics, fluid dynamics, heat and mass transfer, electrical systems, control systems and communication systems. Also, they typically involve multiple temporal and spatial scales, and their evolution can be described bymore » coupled differential equations, discrete equations and events. Modeling and simulating such systems requires a higher level of abstraction and modularisation to manage the increased complexity compared to what is used in today's building simulation programs. Therefore, the trend towards more integrated building systems is likely to be a driving force for changing the status quo of today's building simulation programs. Thischapter discusses evolving modeling requirements and outlines a path toward a future environment for modeling and simulation of heterogeneous building systems.A range of topics that would require many additional pages of discussion has been omitted. Examples include computational fluid dynamics for air and particle flow in and around buildings, people movement, daylight simulation, uncertainty propagation and optimisation methods for building design and controls. For different discussions and perspectives on the future of building modeling and simulation, we refer to Sahlin (2000), Augenbroe (2001) and Malkawi and Augenbroe (2004).« less

The minicell TMirradiator: A new system for a new market

NASA Astrophysics Data System (ADS)

Clouser, James F.; Beers, Eric W.

1998-06-01

Since the commissioning of the first industrial Gamma Irradiator design, designers and operators of irradiation systems have been attempting to meet the specific production requirements and challenges presented to them. This objective has resulted in many different versions of irradiators currently in service today, all of which had original charters and many of which still perform very well within even the new requirements of this industry. Continuing changes in the marketplace have, however, placed pressures on existing designs due to a combination of changing dose requirements for sterlization, increased economic pressures from the specific industry served for both time and location and the increasing variety of product types requiring processing. Additionally, certain market areas which could never economically support a typical gamma processing facility have either not been serviced, or have forced potential gamma users to transport product long distances to one of these existing facilities. The MiniCell TM removes many of the traditional barriers previously accepted in the radiation processing industry for building a processing facility in a location. Its reduced size and cost have allowed many potential users to consider in-house processing and its ability to be quickly assembled allow it to meet market needs in a much more timely fashion than the previous designs. The MiniCell system can cost effectively meet many of the current market needs of reducing total cost of processing and also be flexible enough to process product in a wide range of industries effectively.

Lunar Navigation with Libration Point Orbiters and GPS

NASA Technical Reports Server (NTRS)

Carpenter, J. Russell

2004-01-01

NASA is currently studying a Vision for Space Exploration based on spiral development of robotic and piloted missions to the moon and Mars, but research into how to perform such missions has continued ever since the first era of lunar exploration. One area of study that a number of researchers have pursued is libration point navigation and communication relay concepts. These concepts would appear to support many of NASA's current requirements for navigation and communications coverage for human and robotic spacecraft operating in lunar space and beyond. In trading libration point concepts against other options, designers must consider issues such as the number of spacecraft, required to provide coverage, insertion and stationkeeping costs, power and data rate requirements, frequency allocations, and many others. The libration points, along with a typical cis-lunar trajectory, are equilibrium locations for an infinitesimal mass in the rotating coordinate system that follows the motion of two massive bodies in circular orbits with respect to their common barycenter. There are three co-linear points along the line connecting the massive bodies: between the bodies, beyond the secondary body, and beyond the primary body. The relative distances of these points along the line connecting the bodies depend on the mass ratios. There are also two points that form equilateral triangles with the massive bodies. Ideally, motion in the neighborhood of the co-linear points is unstable, while motion near the equilibrium points is stable. However, in the real world, the motions are highly perturbed so that a satellite will require stationkeeping maneuvers.

The Typicality Ranking Task: A New Method to Derive Typicality Judgments from Children.

PubMed

Djalal, Farah Mutiasari; Ameel, Eef; Storms, Gert

2016-01-01

An alternative method for deriving typicality judgments, applicable in young children that are not familiar with numerical values yet, is introduced, allowing researchers to study gradedness at younger ages in concept development. Contrary to the long tradition of using rating-based procedures to derive typicality judgments, we propose a method that is based on typicality ranking rather than rating, in which items are gradually sorted according to their typicality, and that requires a minimum of linguistic knowledge. The validity of the method is investigated and the method is compared to the traditional typicality rating measurement in a large empirical study with eight different semantic concepts. The results show that the typicality ranking task can be used to assess children's category knowledge and to evaluate how this knowledge evolves over time. Contrary to earlier held assumptions in studies on typicality in young children, our results also show that preference is not so much a confounding variable to be avoided, but that both variables are often significantly correlated in older children and even in adults.

The Typicality Ranking Task: A New Method to Derive Typicality Judgments from Children

PubMed Central

Ameel, Eef; Storms, Gert

2016-01-01

An alternative method for deriving typicality judgments, applicable in young children that are not familiar with numerical values yet, is introduced, allowing researchers to study gradedness at younger ages in concept development. Contrary to the long tradition of using rating-based procedures to derive typicality judgments, we propose a method that is based on typicality ranking rather than rating, in which items are gradually sorted according to their typicality, and that requires a minimum of linguistic knowledge. The validity of the method is investigated and the method is compared to the traditional typicality rating measurement in a large empirical study with eight different semantic concepts. The results show that the typicality ranking task can be used to assess children’s category knowledge and to evaluate how this knowledge evolves over time. Contrary to earlier held assumptions in studies on typicality in young children, our results also show that preference is not so much a confounding variable to be avoided, but that both variables are often significantly correlated in older children and even in adults. PMID:27322371

Integrated Vehicle Thermal Management for Advanced Vehicle Propulsion Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennion, K.; Thornton, M.

A critical element to the success of new propulsion technologies that enable reductions in fuel use is the integration of component thermal management technologies within a viable vehicle package. Vehicle operation requires vehicle thermal management systems capable of balancing the needs of multiple vehicle systems that may require heat for operation, require cooling to reject heat, or require operation within specified temperature ranges. As vehicle propulsion transitions away from a single form of vehicle propulsion based solely on conventional internal combustion engines (ICEs) toward a wider array of choices including more electrically dominant systems such as plug-in hybrid electric vehiclesmore » (PHEVs), new challenges arise associated with vehicle thermal management. As the number of components that require active thermal management increase, so do the costs in terms of dollars, weight, and size. Integrated vehicle thermal management is one pathway to address the cost, weight, and size challenges. The integration of the power electronics and electric machine (PEEM) thermal management with other existing vehicle systems is one path for reducing the cost of electric drive systems. This work demonstrates techniques for evaluating and quantifying the integrated transient and continuous heat loads of combined systems incorporating electric drive systems that operate primarily under transient duty cycles, but the approach can be extended to include additional steady-state duty cycles typical for designing vehicle thermal management systems of conventional vehicles. The work compares opportunities to create an integrated low temperature coolant loop combining the power electronics and electric machine with the air conditioning system in contrast to a high temperature system integrated with the ICE cooling system.« less

Continuity of operations/continuity of government for state-level transportation organizations : brief.

DOT National Transportation Integrated Search

2011-09-01

As a result of a federal requirement, all non-federal entities that own or operate critical : infrastructure are required to develop Continuity of Operations/Continuity of Government : (COOP/COG) Plans. Transportation is a critical infrastructure com...

Phase and widening construction of steel bridges.

DOT National Transportation Integrated Search

2014-03-01

Phase construction is used to maintain traffic without interruption and generally refers to sequenced construction where a portion of the bridge is under construction while the remainder continues to carry traffic. The method typically results in two...

Continuous prestressed concrete girder bridges volume 1 : literature review and preliminary designs.

DOT National Transportation Integrated Search

2012-06-01

The Texas Department of Transportation (TxDOT) is currently designing typical highway bridge structures as simply supported using standard precast, pretensioned girders. TxDOT is interested in developing additional economical design alternatives for ...

Simple Heat Treatment for Production of Hot-Dip Galvanized Dual Phase Steel Using Si-Al Steels

NASA Astrophysics Data System (ADS)

Equihua-Guillén, F.; García-Lara, A. M.; Muñíz-Valdes, C. R.; Ortíz-Cuellar, J. C.; Camporredondo-Saucedo, J. E.

2014-01-01

This work presents relevant metallurgical considerations to produce galvanized dual phase steels from low cost aluminum-silicon steels which are produced by continuous strip processing. Two steels with different contents of Si and Al were austenized in the two-phase field ferrite + austenite (α + γ) in a fast manner to obtain dual phase steels, suitable for hot-dip galvanizing process, under typical parameters of continuous annealing processing line. Tensile dual phase properties were obtained from specimens cooled from temperature below Ar3, held during 3 min, intermediate cooling at temperature above Ar1 and quenching in Zn bath at 465 °C. The results have shown typical microstructure and tensile properties of galvanized dual phase steels. Finally, the synergistic effect of aluminum, silicon, and residual chromium on martensite start temperature ( M s), critical cooling rate ( C R), volume fraction of martensite, and tensile properties has been studied.

Magnesium-Assisted Continuous Growth of Strongly Iron-Enriched Incisors.

PubMed

Srot, Vesna; Bussmann, Birgit; Salzberger, Ute; Deuschle, Julia; Watanabe, Masashi; Pokorny, Boštjan; Jelenko Turinek, Ida; Mark, Alison F; van Aken, Peter A

2017-01-24

Teeth are an excellent example where optimally designed nanoarchitectures with precisely constructed components consist of simple compounds. Typically, these simple constituent phases with insignificant properties show mechanical property amplifications when formed into composite architectures. Material properties of functional composites are generally regulated on the nanoscale, which makes their characterization particularly demanding. Using advanced analytical and imaging transmission electron microscopy techniques, we identified innovative microstructural adjustments combined with astonishing compositional adaptations in incisors of coypu. Unique constituents, recognized as an additional amorphous Fe-rich surface layer followed by a transition zone covering pigmented enamel, provide the required structural stability to withstand repeated mechanical load. The chemically diverse Fe-rich surface layer, including ferrihydrite and iron-calcium phosphates, gives the typical orange-brown coloration to the incisors. Within the spaces between elongated hydroxyapatite crystals in the pigmented enamel, only ferrihydrite was found, implying that enamel pigmentation is a very strictly controlled process. Most significantly, an unprecedentedly high amount of Mg was measured in the amorphous flake-like material within the dentinal tubules of the incisors, suggesting the presence of a (Mg,Ca) phosphate phase. This unusually high influx of Mg into the dentin of incisors, but not molars, suggests a substantial functionality of Mg in the initial formation stages and constant growth of incisors. The present results emphasize the strong mutual correlation among the microstructure, chemical composition, and mechanical properties of mineralized dental tissues.

Developmental frontal lobe imaging in moral judgment: Arthur Benton's enduring influence 60 years later.

PubMed

Eslinger, Paul J; Robinson-Long, Melissa; Realmuto, Jennifer; Moll, Jorge; deOliveira-Souza, Ricardo; Tovar-Moll, Fernanda; Wang, Jianli; Yang, Qing X

2009-02-01

Early prefrontal cortex damage has been associated with developmental deficits in social adaptation, moral behavior, and empathy that alter the maturation of social cognition and social emotions. The seminal case of Ackerly and Benton (1948) continues to provide the most striking clinical example of prefrontal-related neurodevelopmental impairments, with more recent case reports confirming and elaborating these influential observations. This study investigated the prefrontal hypothesis of moral decision making in healthy, typically developing children and adolescents (10-17 years of age) using functional magnetic resonance imaging (fMRI). Participants judged the actions in age-appropriate moral vignettes as right or wrong, and results were contrasted to a nonsocial/nonmoral baseline condition requiring similar right versus wrong judgments. Results confirmed a predominant cluster of activity in the most rostral-medial (frontal polar) prefrontal region across moral judgment conditions, along with left lateroposterior orbitofrontal/ventrolateral prefrontal, left temporoparietal junction, midline thalamus and globus pallidus, and bilateral inferior occipital clusters. Trials entailing ambiguous moral situations activated considerably more prefrontal and parietal regions than did routine moral situations, suggesting the need for more neurocognitive resources. While age regression analysis identified a few regions of greater or lesser activity with age, the frontal polar activations did not change with age. Findings confirm a significant role for anterior-medial prefrontal cortex in the typical development and maturation of moral decision making, consistent with clinical lesion case descriptions.

Geoethics As a Key Component to an Undergraduate Capstone Experience

NASA Astrophysics Data System (ADS)

Geissman, J. W.; McFadden, L. D.

2014-12-01

We have taught a required, senior, capstone course, with a focus on geoscience communication, for almost 35 years. While both of us were at the University of New Mexico, we alternated responsibility for teaching this course. The first author continues to teach a similar course at the University of Texas at Dallas. As the course has evolved and new approaches taken, we have incorporated more and more subject matter related to ethics in science and in particular the geological sciences. Our experiences indicate that (1) students are typically enthralled by and curious about the subject, (2) students have received little if any exposure to the subject in any form of formal classroom environment, and (3) students have personally experienced situations or have learned of situations from their peers that have left them in an uncomfortable position and left them questioning the appropriateness of the actions witnessed. We typically introduce the subject of GeoEthics by drawing students' attention to the many Codes of Ethics or Professional Conduct assembled by Geoscience societies. Many students are quick to volunteer their experiences related to specific topics. For example, the statement in the Geological Society of America Code of Conduct, "Geoscientists should treat associates with respect, regardless of the level of their formal education, encourage them, learn with them, share ideas honestly, and give credit for their contributions" often incites lively discussion and reveals repeated behavior by some individuals.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Labby, Z.

Physicists are often expected to have a solid grounding in experimental design and statistical analysis, sometimes filling in when biostatisticians or other experts are not available for consultation. Unfortunately, graduate education on these topics is seldom emphasized and few opportunities for continuing education exist. Clinical physicists incorporate new technology and methods into their practice based on published literature. A poor understanding of experimental design and analysis could Result in inappropriate use of new techniques. Clinical physicists also improve current practice through quality initiatives that require sound experimental design and analysis. Academic physicists with a poor understanding of design and analysismore » may produce ambiguous (or misleading) results. This can Result in unnecessary rewrites, publication rejection, and experimental redesign (wasting time, money, and effort). This symposium will provide a practical review of error and uncertainty, common study designs, and statistical tests. Instruction will primarily focus on practical implementation through examples and answer questions such as: where would you typically apply the test/design and where is the test/design typically misapplied (i.e., common pitfalls)? An analysis of error and uncertainty will also be explored using biological studies and associated modeling as a specific use case. Learning Objectives: Understand common experimental testing and clinical trial designs, what questions they can answer, and how to interpret the results Determine where specific statistical tests are appropriate and identify common pitfalls Understand the how uncertainty and error are addressed in biological testing and associated biological modeling.« less

Vacuum-ultraviolet lasers and spectroscopy

NASA Astrophysics Data System (ADS)

Hollenstein, U.

2012-01-01

Single-photon ionisation of most atoms and molecules requires short-wavelength radiation, typically in the vacuum-ultraviolet (VUV, λ < 200 nm) or extreme ultraviolet (XUV, λ < 105 nm) region of the electromagnetic spectrum. The first VUV and XUV radiation sources used to study molecular photoabsorption and photoionisation spectra were light sources emitting a broad continuous spectrum, such as high pressure lamps or synchrotrons. Monochromatic VUV and XUV radiation was obtained using diffraction gratings in evacuated monochromators, which resulted in a resolving power ν/Δv of at best 106 (i. e. 0.1 cm-1 at 100 000 cm-1), but more typically in the range 104-105 . The invention of the laser and the development of nonlinear optical frequency-upconversion techniques enabled the development of table-top narrow-bandwidth, coherent VUV and XUV laser sources with which VUV photoabsorption, photoionisation and photoelectron spectra of molecules can be recorded at much higher resolution, the best sources having bandwidths better than 50 MHz. Such laser sources are ideally suited to study the structure and dynamics of electronically excited states of atoms and molecules and molecular photoionisation using photoabsorption, photoionisation and photoelectron spectroscopy. This chapter presents the general principles that are exploited to generate tunable narrow-band laser radiation below 200 nm and describes spectroscopic methods such as photoabsorption spectroscopy, photoionisation spectroscopy and threshold photoelectron spectroscopy that relay on the broad tunability and narrow-bandwidth of VUV radiation sources.

Inline UV/Vis spectroscopy as PAT tool for hot-melt extrusion.

PubMed

Wesholowski, Jens; Prill, Sebastian; Berghaus, Andreas; Thommes, Markus

2018-01-11

Hot-melt extrusion on co-rotating twin screw extruders is a focused technology for the production of pharmaceuticals in the context of Quality by Design. Since it is a continuous process, the potential for minimizing product quality fluctuation is enhanced. A typical application of hot-melt extrusion is the production of solid dispersions, where an active pharmaceutical ingredient (API) is distributed within a polymer matrix carrier. For this dosage form, the product quality is related amongst others to the drug content. This can be monitored on- or inline as critical quality attribute by a process analytical technology (PAT) in order to meet the specific requirements of Quality by Design. In this study, an inline UV/Vis spectrometer from ColVisTec was implemented in an early development twin screw extruder and the performance tested in accordance to the ICH Q2 guideline. Therefore, two API (carbamazepine and theophylline) and one polymer matrix (copovidone) were considered with the main focus on the quantification of the drug load. The obtained results revealed the suitability of the implemented PAT tool to quantify the drug load in a typical range for pharmaceutical applications. The effort for data evaluation was minimal due to univariate data analysis, and in combination with a measurement frequency of 1 Hz, the system is sufficient for real-time data acquisition.

40 CFR 63.10420 - How do I demonstrate continuous compliance with the management practice requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... compliance with the management practice requirements? 63.10420 Section 63.10420 Protection of Environment... continuous compliance with the management practice requirements? For each sterilization unit not equipped with an air pollution control device, you must demonstrate continuous compliance with the management...

26 CFR 1.613A-6 - Recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Recordkeeping requirements. 1.613A-6 Section 1.613A-6 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1.613A-6 Recordkeeping requirements. (a) Principal...

40 CFR 60.1805 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2010 CFR

2010-07-01

... continuous monitoring? 60.1805 Section 60.1805 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Model Rule-Other Monitoring Requirements § 60.1805 Must I meet other requirements for continuous... device. (c) Carbon feed rate if activated carbon is used to control dioxins/furans or mercury emissions. ...

40 CFR 60.1315 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2012 CFR

2012-07-01

... continuous monitoring? 60.1315 Section 60.1315 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1315 Must I meet other requirements for continuous monitoring? You must also monitor three... at the inlet of your particulate matter air pollution control device. (c) Carbon feed rate if...

40 CFR 60.1315 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2010 CFR

2010-07-01

... continuous monitoring? 60.1315 Section 60.1315 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1315 Must I meet other requirements for continuous monitoring? You must also monitor three... at the inlet of your particulate matter air pollution control device. (c) Carbon feed rate if...

40 CFR 60.1315 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2014 CFR

2014-07-01

... continuous monitoring? 60.1315 Section 60.1315 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1315 Must I meet other requirements for continuous monitoring? You must also monitor three... at the inlet of your particulate matter air pollution control device. (c) Carbon feed rate if...

40 CFR 60.1315 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2013 CFR

2013-07-01

... continuous monitoring? 60.1315 Section 60.1315 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1315 Must I meet other requirements for continuous monitoring? You must also monitor three... at the inlet of your particulate matter air pollution control device. (c) Carbon feed rate if...

40 CFR 60.1805 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2014 CFR

2014-07-01

... continuous monitoring? 60.1805 Section 60.1805 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Model Rule-Other Monitoring Requirements § 60.1805 Must I meet other requirements for continuous... device. (c) Carbon feed rate if activated carbon is used to control dioxins/furans or mercury emissions. ...

40 CFR 60.1315 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2011 CFR

2011-07-01

... continuous monitoring? 60.1315 Section 60.1315 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1315 Must I meet other requirements for continuous monitoring? You must also monitor three... at the inlet of your particulate matter air pollution control device. (c) Carbon feed rate if...

40 CFR 60.1805 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2012 CFR

2012-07-01

... continuous monitoring? 60.1805 Section 60.1805 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Model Rule-Other Monitoring Requirements § 60.1805 Must I meet other requirements for continuous... device. (c) Carbon feed rate if activated carbon is used to control dioxins/furans or mercury emissions. ...

40 CFR 60.1805 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2013 CFR

2013-07-01

... continuous monitoring? 60.1805 Section 60.1805 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Model Rule-Other Monitoring Requirements § 60.1805 Must I meet other requirements for continuous... device. (c) Carbon feed rate if activated carbon is used to control dioxins/furans or mercury emissions. ...

40 CFR 60.1805 - Must I meet other requirements for continuous monitoring?

Code of Federal Regulations, 2011 CFR

2011-07-01

... continuous monitoring? 60.1805 Section 60.1805 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Model Rule-Other Monitoring Requirements § 60.1805 Must I meet other requirements for continuous... device. (c) Carbon feed rate if activated carbon is used to control dioxins/furans or mercury emissions. ...

Boiler and Pressure Balls Monopropellant Thermal Rocket Engine

NASA Technical Reports Server (NTRS)

Greene, William D. (Inventor)

2009-01-01

The proposed technology is a rocket engine cycle utilizing as the propulsive fluid a low molecular weight, cryogenic fluid, typically liquid hydrogen, pressure driven, heated, and expelled through a nozzle to generate high velocity and high specific impulse discharge gas. The proposed technology feeds the propellant through the engine cycle without the use of a separate pressurization fluid and without the use of turbomachinery. Advantages of the proposed technology are found in those elements of state-of-the-art systems that it avoids. It does not require a separate pressurization fluid or a thick-walled primary propellant tank as is typically required for a classical pressure-fed system. Further, it does not require the acceptance of intrinsic reliability risks associated with the use of turbomachinery

Interaction Support for Information Finding and Comparative Analysis in Online Video

ERIC Educational Resources Information Center

Xia, Jinyue

2017-01-01

Current online video interaction is typically designed with a focus on straightforward distribution and passive consumption of individual videos. This "click play, sit back and watch" context is typical of videos for entertainment. However, there are many task scenarios that require active engagement and analysis of video content as a…

An overview of smart grid routing algorithms

NASA Astrophysics Data System (ADS)

Wang, Junsheng; OU, Qinghai; Shen, Haijuan

2017-08-01

This paper summarizes the typical routing algorithm in smart grid by analyzing the communication business and communication requirements of intelligent grid. Mainly from the two kinds of routing algorithm is analyzed, namely clustering routing algorithm and routing algorithm, analyzed the advantages and disadvantages of two kinds of typical routing algorithm in routing algorithm and applicability.

The Representational Status of Pretence: Evidence from Typical Development and Autism

ERIC Educational Resources Information Center

Jarrold, Christopher; Mansergh, Ruth; Whiting, Claire

2010-01-01

The question of whether understanding pretend play requires meta-representational skill was examined among typically developing children and individuals with autism. Participants were presented with closely equated true and false pretence trials in which they had to judge a protagonist's pretend reading of a situation, which either matched or…

Association between participation and compliance with Continuing Medical Education and care production by physicians: a cross-sectional study

PubMed Central

Carrera, Renato Melli; Cendoroglo, Miguel; Gonçales, Paulo David Scatena; Marques, Flavio Rocha Brito; Sardenberg, Camila; Glezer, Milton; dos Santos, Oscar Fernando Pavão; Rizzo, Luiz Vicente; Lottenberg, Claudio Luiz; Schvartsman, Cláudio

2015-01-01

Objective Physician participation in Continuing Medical Education programs may be influenced by a number of factors. To evaluate the factors associated with compliance with the Continuing Medical Education requirements at a private hospital, we investigated whether physicians’ activity, measured by volumes of admissions and procedures, was associated with obtaining 40 Continuing Medical Education credits (40 hours of activities) in a 12-month cycle. Methods In an exclusive and non-mandatory Continuing Medical Education program, we collected physicians’ numbers of hospital admissions and numbers of surgical procedures performed. We also analyzed data on physicians’ time since graduation, age, and gender. Results A total of 3,809 credentialed, free-standing, private practice physicians were evaluated. Univariate analysis showed that the Continuing Medical Education requirements were more likely to be achieved by male physicians (odds ratio 1.251; p=0.009) and who had a higher number of hospital admissions (odds ratio 1.022; p<0.001). Multivariate analysis showed that age and number of hospital admissions were associated with achievement of the Continuing Medical Education requirements. Each hospital admission increased the chance of achieving the requirements by 0.4%. Among physicians who performed surgical procedures, multivariate analysis showed that male physicians were 1.3 time more likely to achieve the Continuing Medical Education requirements than female physicians. Each surgical procedure performed increased the chance of achieving the requirements by 1.4%. Conclusion The numbers of admissions and number of surgical procedures performed by physicians at our hospital were associated with the likelihood of meeting the Continuing Medical Education requirements. These findings help to shed new light on our Continuing Medical Education program. PMID:25807247

Geostationary Platforms Mission and Payload Requirements study. Volume 2: Technical

NASA Technical Reports Server (NTRS)

1979-01-01

The possibility of using geostationary platforms to provide communications and other services was examined. Detailed data on the payload and housekeeping requirements of selected communications missions and one typical noncommunications mission are presented.

Continuous-flow multi-pulse electroporation at low DC voltages by microfluidic flipping of the voltage space topology

NASA Astrophysics Data System (ADS)

Bhattacharjee, N.; Horowitz, L. F.; Folch, A.

2016-10-01

Concerns over biosafety, cost, and carrying capacity of viral vectors have accelerated research into physical techniques for gene delivery such as electroporation and mechanoporation. Advances in microfabrication have made it possible to create high electric fields over microscales, resulting in more efficient DNA delivery and higher cell viability. Continuous-flow microfluidic methods are typically more suitable for cellular therapies where a large number of cells need to be transfected under sterile conditions. However, the existing continuous-flow designs used to generate multiple pulses either require expensive peripherals such as high-voltage (>400 V) sources or function generators, or result in reduced cell viability due to the proximity of the cells to the electrodes. In this paper, we report a continuous-flow microfluidic device whose channel geometry reduces instrumentation demands and minimizes cellular toxicity. Our design can generate multiple pulses of high DC electric field strength using significantly lower voltages (15-60 V) than previous designs. The cells flow along a serpentine channel that repeatedly flips the cells between a cathode and an anode at high throughput. The cells must flow through a constriction each time they pass from an anode to a cathode, exposing them to high electric field strength for short durations of time (the "pulse-width"). A conductive biocompatible poly-aniline hydrogel network formed in situ is used to apply the DC voltage without bringing the metal electrodes close to the cells, further sheltering cells from the already low voltage electrodes. The device was used to electroporate multiple cell lines using electric field strengths between 700 and 800 V/cm with transfection efficiencies superior than previous flow-through designs.

Continuous-flow multi-pulse electroporation at low DC voltages by microfluidic flipping of the voltage space topology.

PubMed

Bhattacharjee, N; Horowitz, L F; Folch, A

2016-10-17

Concerns over biosafety, cost, and carrying capacity of viral vectors have accelerated research into physical techniques for gene delivery such as electroporation and mechanoporation. Advances in microfabrication have made it possible to create high electric fields over microscales, resulting in more efficient DNA delivery and higher cell viability. Continuous-flow microfluidic methods are typically more suitable for cellular therapies where a large number of cells need to be transfected under sterile conditions. However, the existing continuous-flow designs used to generate multiple pulses either require expensive peripherals such as high-voltage (>400 V) sources or function generators, or result in reduced cell viability due to the proximity of the cells to the electrodes. In this paper, we report a continuous-flow microfluidic device whose channel geometry reduces instrumentation demands and minimizes cellular toxicity. Our design can generate multiple pulses of high DC electric field strength using significantly lower voltages (15-60 V) than previous designs. The cells flow along a serpentine channel that repeatedly flips the cells between a cathode and an anode at high throughput. The cells must flow through a constriction each time they pass from an anode to a cathode, exposing them to high electric field strength for short durations of time (the "pulse-width"). A conductive biocompatible poly-aniline hydrogel network formed in situ is used to apply the DC voltage without bringing the metal electrodes close to the cells, further sheltering cells from the already low voltage electrodes. The device was used to electroporate multiple cell lines using electric field strengths between 700 and 800 V/cm with transfection efficiencies superior than previous flow-through designs.

Design, construction, and optimization of a novel, modular, and scalable incubation chamber for continuous viral inactivation.

PubMed

Orozco, Raquel; Godfrey, Scott; Coffman, Jon; Amarikwa, Linus; Parker, Stephanie; Hernandez, Lindsay; Wachuku, Chinenye; Mai, Ben; Song, Brian; Hoskatti, Shashidhar; Asong, Jinkeng; Shamlou, Parviz; Bardliving, Cameron; Fiadeiro, Marcus

2017-07-01

We designed, built or 3D printed, and screened tubular reactors that minimize axial dispersion to serve as incubation chambers for continuous virus inactivation of biological products. Empirical residence time distribution data were used to derive each tubular design's volume equivalent to a theoretical plate (VETP) values at a various process flow rates. One design, the Jig in a Box (JIB), yielded the lowest VETP, indicating optimal radial mixing and minimal axial dispersion. A minimum residence time (MRT) approach was employed, where the MRT is the minimum time the product spends in the tubular reactor. This incubation time is typically 60 minutes in a batch process. We provide recommendations for combinations of flow rates and device dimensions for operation of the JIB connected in series that will meet a 60-min MRT. The results show that under a wide range of flow rates and corresponding volumes, it takes 75 ± 3 min for 99% of the product to exit the reactor while meeting the 60-min MRT criterion and fulfilling the constraint of keeping a differential pressure drop under 5 psi. Under these conditions, the VETP increases slightly from 3 to 5 mL though the number of theoretical plates stays constant at about 1326 ± 88. We also demonstrated that the final design volume was only 6% ± 1% larger than the ideal plug flow volume. Using such a device would enable continuous viral inactivation in a truly continuous process or in the effluent of a batch chromatography column. Viral inactivation studies would be required to validate such a design. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:954-965, 2017. © 2017 American Institute of Chemical Engineers.

Reinforcement Learning Using a Continuous Time Actor-Critic Framework with Spiking Neurons

PubMed Central

Frémaux, Nicolas; Sprekeler, Henning; Gerstner, Wulfram

2013-01-01

Animals repeat rewarded behaviors, but the physiological basis of reward-based learning has only been partially elucidated. On one hand, experimental evidence shows that the neuromodulator dopamine carries information about rewards and affects synaptic plasticity. On the other hand, the theory of reinforcement learning provides a framework for reward-based learning. Recent models of reward-modulated spike-timing-dependent plasticity have made first steps towards bridging the gap between the two approaches, but faced two problems. First, reinforcement learning is typically formulated in a discrete framework, ill-adapted to the description of natural situations. Second, biologically plausible models of reward-modulated spike-timing-dependent plasticity require precise calculation of the reward prediction error, yet it remains to be shown how this can be computed by neurons. Here we propose a solution to these problems by extending the continuous temporal difference (TD) learning of Doya (2000) to the case of spiking neurons in an actor-critic network operating in continuous time, and with continuous state and action representations. In our model, the critic learns to predict expected future rewards in real time. Its activity, together with actual rewards, conditions the delivery of a neuromodulatory TD signal to itself and to the actor, which is responsible for action choice. In simulations, we show that such an architecture can solve a Morris water-maze-like navigation task, in a number of trials consistent with reported animal performance. We also use our model to solve the acrobot and the cartpole problems, two complex motor control tasks. Our model provides a plausible way of computing reward prediction error in the brain. Moreover, the analytically derived learning rule is consistent with experimental evidence for dopamine-modulated spike-timing-dependent plasticity. PMID:23592970

Reinforcement learning using a continuous time actor-critic framework with spiking neurons.

PubMed

Frémaux, Nicolas; Sprekeler, Henning; Gerstner, Wulfram

2013-04-01

Animals repeat rewarded behaviors, but the physiological basis of reward-based learning has only been partially elucidated. On one hand, experimental evidence shows that the neuromodulator dopamine carries information about rewards and affects synaptic plasticity. On the other hand, the theory of reinforcement learning provides a framework for reward-based learning. Recent models of reward-modulated spike-timing-dependent plasticity have made first steps towards bridging the gap between the two approaches, but faced two problems. First, reinforcement learning is typically formulated in a discrete framework, ill-adapted to the description of natural situations. Second, biologically plausible models of reward-modulated spike-timing-dependent plasticity require precise calculation of the reward prediction error, yet it remains to be shown how this can be computed by neurons. Here we propose a solution to these problems by extending the continuous temporal difference (TD) learning of Doya (2000) to the case of spiking neurons in an actor-critic network operating in continuous time, and with continuous state and action representations. In our model, the critic learns to predict expected future rewards in real time. Its activity, together with actual rewards, conditions the delivery of a neuromodulatory TD signal to itself and to the actor, which is responsible for action choice. In simulations, we show that such an architecture can solve a Morris water-maze-like navigation task, in a number of trials consistent with reported animal performance. We also use our model to solve the acrobot and the cartpole problems, two complex motor control tasks. Our model provides a plausible way of computing reward prediction error in the brain. Moreover, the analytically derived learning rule is consistent with experimental evidence for dopamine-modulated spike-timing-dependent plasticity.

A Continuous Long-Term Record of Magnetic-Storm Occurrence and Intensity

NASA Astrophysics Data System (ADS)

Love, J. J.

2007-05-01

Hourly magnetometer data have been produced by ground-based magnetic observatories for over a century. These data are used for a wide variety of applications, including many for space physics. In particular, hourly data from a longitudinal necklace of mid-latitude observatories can be used to construct a time series recording the storm-time disturbance index Dst, one of the most useful scalar summaries of magnetic storm intensity which is generally interpreted in terms of an equivalent equatorial magnetospheric ring current. Dst has been routinely calculated in a temporally piece-wise fashion since the IGY using a subset of the available observatories: four or five stations, typically including Honolulu (HON), San Juan (SJG), Kakioka Japan (KAK), Hermanus South Africa (HER), and Alibag India (ABG). In this presentation we discuss a single continuous Dst time series made using a denser and more uniform distribution of observatories than that which is standard: including, additionally, Watheroo Australia (WAT), Apia Samoa (API), and Vassouras Brazil (VSS). Starting first with the data from each individual observatory, we subtract the geomagnetic secular variation, caused primarily by the core dynamo, and the solar-quiet (Sq) variation, caused primarily by the ionospheric dynamo. The latter requires careful spectral analysis, and those intermediate results are, themselves, of scientific interest. Following this, we combine the disturbance residuals from each station to form the continuous Dst time series. Statistics deduced from this model allow us to quantify the likelihood of storm occurrence and intensity, both of which are modulated in time by the solar cycle. This analysis is accomplished using a 50 year Dst time series. The prospects for constructing a longer continuous Dst time series are discussed.

An order (n) algorithm for the dynamics simulation of robotic systems

NASA Technical Reports Server (NTRS)

Chun, H. M.; Turner, J. D.; Frisch, Harold P.

1989-01-01

The formulation of an Order (n) algorithm for DISCOS (Dynamics Interaction Simulation of Controls and Structures), which is an industry-standard software package for simulation and analysis of flexible multibody systems is presented. For systems involving many bodies, the new Order (n) version of DISCOS is much faster than the current version. Results of the experimental validation of the dynamics software are also presented. The experiment is carried out on a seven-joint robot arm at NASA's Goddard Space Flight Center. The algorithm used in the current version of DISCOS requires the inverse of a matrix whose dimension is equal to the number of constraints in the system. Generally, the number of constraints in a system is roughly proportional to the number of bodies in the system, and matrix inversion requires O(p exp 3) operations, where p is the dimension of the matrix. The current version of DISCOS is therefore considered an Order (n exp 3) algorithm. In contrast, the Order (n) algorithm requires inversion of matrices which are small, and the number of matrices to be inverted increases only linearly with the number of bodies. The newly-developed Order (n) DISCOS is currently capable of handling chain and tree topologies as well as multiple closed loops. Continuing development will extend the capability of the software to deal with typical robotics applications such as put-and-place, multi-arm hand-off and surface sliding.

Resonant UPS topologies for the emerging hybrid fiber-coaxial networks

NASA Astrophysics Data System (ADS)

Pinheiro, Humberto

Uninterruptible power supply (UPS) systems have been extensively applied to feed critical loads in many areas. Typical examples of critical loads include life-support equipment, computers and telecommunication systems. Although all UPS systems have a common purpose to provide continuous power-to critical loads, the emerging hybrid fiber-coaxial networks have created the need for specific types of UPS topologies. For example, galvanic isolation for the load and the battery, small size, high input power factor, and trapezoidal output voltage waveforms are among the required features of UPS topologies for hybrid fiber-coaxial networks. None of the conventional UPS topologies meet all these requirements. Consequently. this thesis is directed towards the design and analysis of UPS topologies for this new application. Novel UPS topologies are proposed and control techniques are developed to allow operation at high switching frequencies without penalizing the converter efficiency. By the use of resonant converters in the proposed UPS topologies. a high input power factor is achieved without requiring a dedicated power factor correction stage. In addition, a self-sustained oscillation control method is proposed to ensure soft switching under all operating conditions. A detailed analytical treatment of the resonant converters in the proposed UPS topologies is presented and design procedures illustrated. Simulation and experimental results are presented to validate the analyses and to demonstrate the feasibility of the proposed schemes.

26 CFR 1.410(b)-1 - Minimum coverage requirements (before 1994).

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc... the minimum age and service requirements (if any) prescribed by the plan, as of the date coverage is... employees (including employees who do not satisfy the minimum age or service requirements of the plan) are...

24 CFR 206.308 - Continuing education requirements of counselors listed on the HECM Counselor Roster.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Continuing education requirements of counselors listed on the HECM Counselor Roster. 206.308 Section 206.308 Housing and Urban... MORTGAGE INSURANCE HECM Counselor Roster § 206.308 Continuing education requirements of counselors listed...

40 CFR Table 7 to Subpart Jjj of... - Requirements for Continuous Emission Monitoring Systems (CEMS) a

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Requirements for Continuous Emission Monitoring Systems (CEMS) a 7 Table 7 to Subpart JJJ of Part 62 Protection of Environment ENVIRONMENTAL...—Requirements for Continuous Emission Monitoring Systems (CEMS) a ER31JA03.013 ...

40 CFR Table 7 to Subpart Jjj of... - Requirements for Continuous Emission Monitoring Systems (CEMS) a

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Requirements for Continuous Emission Monitoring Systems (CEMS) a 7 Table 7 to Subpart JJJ of Part 62 Protection of Environment ENVIRONMENTAL...—Requirements for Continuous Emission Monitoring Systems (CEMS) a ER31JA03.013 ...

14 CFR 1216.306 - Actions normally requiring an EIS.

Code of Federal Regulations, 2013 CFR

2013-01-01

... normally requiring an EIS. (a) NASA will prepare an EIS for actions with the potential to significantly... action or mitigation of its potentially significant impacts. (b) Typical NASA actions normally requiring... material greater than the quantity for which the NASA Nuclear Flight Safety Assurance Manager may grant...

ENVIRONMENTAL STEWARDSHIP OF PHARMACEUTICALS - THE GREEN PHARMACY

EPA Science Inventory

The occurrence of pharmaceuticals and personal care products (PPCPS) as environmental pollutants is a multifaceted issue whose scope continues to become better delineated since the escalation of conceited attention beginning in the 1980s. PPCPs typically occur as trace environme...

Using microsimulation to evaluate the effects of advanced vehicle technologies on congestion.

DOT National Transportation Integrated Search

2011-06-30

Advanced driver assistance technologies are continuously being developed to enhance traffic : safety. Evaluations of such technologies typically focus on safety and there has been limited : research on the impacts of such technologies on traffic oper...

Using Microsimulation to Evaluate the Effects of Advanced Vehicle Technologies on Congestion

DOT National Transportation Integrated Search

2011-06-30

Advanced driver assistance technologies are continuously being developed to enhance traffic safety. Evaluations of such technologies typically focus on safety and there has been limited research on the impacts of such technologies on traffic operatio...

21 CFR 807.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES...) Representative sampling of advertisements means typical advertising material that gives the promotional claims... change includes any change or modification in the labeling or advertisements that affects the identity or...

21 CFR 807.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES...) Representative sampling of advertisements means typical advertising material that gives the promotional claims... change includes any change or modification in the labeling or advertisements that affects the identity or...

Growth Dynamics of Information Search Services

ERIC Educational Resources Information Center

Lindquist, Mats G.

1978-01-01

An analysis of computer-based search services (ISSs) from a system's viewpoint, using a continuous simulation model to reveal growth and stagnation of a typical system is presented, as well as an analysis of decision making for an ISS. (Author/MBR)

Field evaluations of "ShapeAccelArray" in-place MEMS inclinometer strings for subsurface deformation monitoring.

DOT National Transportation Integrated Search

2012-03-01

Continuous monitoring of subsurface ground movements is accomplished with in-place instruments utilizing automated data acquisition methods. These typically include TDR (Time Domain Reflectometry) or assemblies of several servo-accelerometer-based, e...

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS (PPCPS) AS ENVIRONMENTAL POLLUTANTS

EPA Science Inventory

The occurrence of pharmaceuticals and personal care products (PPCPs) as trace environmental pollutants is a multifaceted issue whose scope of concerns continues to expand. PPCPs comprise thousands of distinct chemicals from numerous therapeutic and consumer classes. They typical...

Continuous prestressed concrete girder bridges, volume 2 : analysis, testing, and recommendations.

DOT National Transportation Integrated Search

2016-12-01

The Texas Department of Transportation designs typical highway bridge structures as simple span systems using : standard precast, pretensioned girders. Spans are limited to about 150 ft due to weight and length restrictions on : transporting the prec...

Evaluation of Data-Logging Transducer to Passively Collect Pressure Vessel p/T History

NASA Technical Reports Server (NTRS)

Wnuk, Stephen P.; Le, Son; Loew, Raymond A.

2013-01-01

Pressure vessels owned and operated by NASA are required to be regularly certified per agency policy. Certification requires an assessment of damage mechanisms and an estimation of vessel remaining life. Since detail service histories are not typically available for most pressure vessels, a conservative estimate of vessel pressure/temperature excursions is typically used in assessing fatigue life. This paper details trial use of a data-logging transducer to passively obtain actual pressure and temperature service histories of pressure vessels. The approach was found to have some potential for cost savings and other benefits in certain cases.

Atmospheric, Magnetospheric and Plasmas in Space (AMPS) spacelab payload definition study - program analysis and planning for phase C/D document - Volume 7

NASA Technical Reports Server (NTRS)

Keeley, J. T.

1976-01-01

Typical missions identified for AMPS flights in the arly 1980's are described. Experiment objectives and typical scientific instruments selected to accomplish these objectives are discussed along with mission requirements and shuttle and Spacelab capabilities assessed to determine any AMPS unique requirements. Preliminary design concepts for the first two AMPS flights form the basis for the Phase C/D program plan. This plan implements flights 1 and 2 and indicates how both the scientific and flight support hardware can be systematically evolved for future AMPS flights.

Alcohol vapour detection at the three phase interface using enzyme-conducting polymer composites.

PubMed

Winther-Jensen, Orawan; Kerr, Robert; Winther-Jensen, Bjorn

2014-02-15

Immobilisation of enzymes on a breathable electrode can be useful for various applications where the three-phase interface between gas or chemical vapour, electrolyte and electrode is crucial for the reaction. In this paper, we report the further development of the breathable electrode concept by immobilisation of alcohol dehydrogenase into vapour-phase polymerised poly(3,4-ethylene dioxythiophene) that has been coated onto a breathable membrane. Typical alcohol sensing, whereby the coenzyme β-Nicotinamide adenine dinucleotide (NADH) is employed as a redox-mediator, was successfully used as a model reaction for the oxidation of ethanol. This indicates that the ethanol vapour from the backside of the membrane has access to the active enzyme embedded in the electrode. The detecting range of the sensor is suitable for the detection of ethanol in fruit juices and for the baseline breath ethanol concentration of drunken driving. After continuous operation for 4.5h the system only showed a 20% decrease in the current output. The electrodes maintained 62% in current output after being refrigerated for 76 days. This work is continuing the progress of the immobilisation of specific enzymes for certain electrochemical reactions whereby the three-phase interface has to be maintained and/or the simultaneous separation of gas from liquid is required. © 2013 Elsevier B.V. All rights reserved.

Electrocorticographic representations of segmental features in continuous speech

PubMed Central

Lotte, Fabien; Brumberg, Jonathan S.; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L.; Guan, Cuntai; Schalk, Gerwin

2015-01-01

Acoustic speech output results from coordinated articulation of dozens of muscles, bones and cartilages of the vocal mechanism. While we commonly take the fluency and speed of our speech productions for granted, the neural mechanisms facilitating the requisite muscular control are not completely understood. Previous neuroimaging and electrophysiology studies of speech sensorimotor control has typically concentrated on speech sounds (i.e., phonemes, syllables and words) in isolation; sentence-length investigations have largely been used to inform coincident linguistic processing. In this study, we examined the neural representations of segmental features (place and manner of articulation, and voicing status) in the context of fluent, continuous speech production. We used recordings from the cortical surface [electrocorticography (ECoG)] to simultaneously evaluate the spatial topography and temporal dynamics of the neural correlates of speech articulation that may mediate the generation of hypothesized gestural or articulatory scores. We found that the representation of place of articulation involved broad networks of brain regions during all phases of speech production: preparation, execution and monitoring. In contrast, manner of articulation and voicing status were dominated by auditory cortical responses after speech had been initiated. These results provide a new insight into the articulatory and auditory processes underlying speech production in terms of their motor requirements and acoustic correlates. PMID:25759647

Fitting models of continuous trait evolution to incompletely sampled comparative data using approximate Bayesian computation.

PubMed

Slater, Graham J; Harmon, Luke J; Wegmann, Daniel; Joyce, Paul; Revell, Liam J; Alfaro, Michael E

2012-03-01

In recent years, a suite of methods has been developed to fit multiple rate models to phylogenetic comparative data. However, most methods have limited utility at broad phylogenetic scales because they typically require complete sampling of both the tree and the associated phenotypic data. Here, we develop and implement a new, tree-based method called MECCA (Modeling Evolution of Continuous Characters using ABC) that uses a hybrid likelihood/approximate Bayesian computation (ABC)-Markov-Chain Monte Carlo approach to simultaneously infer rates of diversification and trait evolution from incompletely sampled phylogenies and trait data. We demonstrate via simulation that MECCA has considerable power to choose among single versus multiple evolutionary rate models, and thus can be used to test hypotheses about changes in the rate of trait evolution across an incomplete tree of life. We finally apply MECCA to an empirical example of body size evolution in carnivores, and show that there is no evidence for an elevated rate of body size evolution in the pinnipeds relative to terrestrial carnivores. ABC approaches can provide a useful alternative set of tools for future macroevolutionary studies where likelihood-dependent approaches are lacking. © 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.

Formulation of a correlated variables methodology for assessment of continuous gas resources with an application to the Woodford play, Arkoma Basin, eastern Oklahoma

USGS Publications Warehouse

Olea, R.A.; Houseknecht, D.W.; Garrity, C.P.; Cook, T.A.

2011-01-01

Shale gas is a form of continuous unconventional hydrocarbon accumulation whose resource estimation is unfeasible through the inference of pore volume. Under these circumstances, the usual approach is to base the assessment on well productivity through estimated ultimate recovery (EUR). Unconventional resource assessments that consider uncertainty are typically done by applying analytical procedures based on classical statistics theory that ignores geographical location, does not take into account spatial correlation, and assumes independence of EUR from other variables that may enter into the modeling. We formulate a new, more comprehensive approach based on sequential simulation to test methodologies known to be capable of more fully utilizing the data and overcoming unrealistic simplifications. Theoretical requirements demand modeling of EUR as areal density instead of well EUR. The new experimental methodology is illustrated by evaluating a gas play in the Woodford Shale in the Arkoma Basin of Oklahoma. Differently from previous assessments, we used net thickness and vitrinite reflectance as secondary variables correlated to cell EUR. In addition to the traditional probability distribution for undiscovered resources, the new methodology provides maps of EUR density and maps with probabilities to reach any given cell EUR, which are useful to visualize geographical variations in prospectivity.

SURMODERR: A MATLAB toolbox for estimation of velocity uncertainties of a non-permanent GPS station

NASA Astrophysics Data System (ADS)

Teza, Giordano; Pesci, Arianna; Casula, Giuseppe

2010-08-01

SURMODERR is a MATLAB toolbox intended for the estimation of reliable velocity uncertainties of a non-permanent GPS station (NPS), i.e. a GPS receiver used in campaign-style measurements. The implemented method is based on the subsampling of daily coordinate time series of one or more continuous GPS stations located inside or close to the area where the NPSs are installed. The continuous time series are subsampled according to real or planned occupation tables and random errors occurring in antenna replacement on different surveys are taken into account. In order to overcome the uncertainty underestimation that typically characterizes short duration GPS time series, statistical analysis of the simulated data is performed to estimate the velocity uncertainties of this real NPS. The basic hypotheses required are: (i) the signal must be a long-term linear trend plus seasonal and colored noise for each coordinate; (ii) the standard data processing should have already been performed to provide daily data series; and (iii) if the method is applied to survey planning, the future behavior should not be significantly different from the past behavior. In order to show the strength of the approach, two case studies with real data are presented and discussed (Central Apennine and Panarea Island, Italy).

Environmental assessment of the Carlsbad Environmental Monitoring and Research Center Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-10-01

This Environmental Assessment has been prepared to determine if the Carlsbad Environmental Monitoring and Research Center (the Center), or its alternatives would have significant environmental impacts that must be analyzed in an Environmental Impact Statement. DOE`s proposed action is to continue funding the Center. While DOE is not funding construction of the planned Center facility, operation of that facility is dependent upon continued funding. To implement the proposed action, the Center would initially construct a facility of approximately 2,300 square meters (25,000 square feet). The Phase 1 laboratory facilities and parking lot will occupy approximately 1.2 hectares (3 acres) ofmore » approximately 8.9 hectares (22 acres) of land which were donated to New Mexico State University (NMSU) for this purpose. The facility would contain laboratories to analyze chemical and radioactive materials typical of potential contaminants that could occur in the environment in the vicinity of the DOE Waste Isolation Pilot Plant (WIPP) site or other locations. The facility also would have bioassay facilities to measure radionuclide levels in the general population and in employees of the WIPP. Operation of the Center would meet the DOE requirement for independent monitoring and assessment of environmental impacts associated with the planned disposal of transuranic waste at the WIPP.« less

Non-mechanical beam steering in the mid-wave infrared

NASA Astrophysics Data System (ADS)

Frantz, Jesse A.; Myers, Jason D.; Bekele, Robel Y.; Spillmann, Christopher M.; Naciri, Jawad; Kolacz, Jakub S.; Gotjen, Henry; Shaw, Leslie B.; Sanghera, Jasbinder S.; Sodergren, Bennett; Wang, Ying-Ju; Rommel, Scott D.; Anderson, Mike; Davis, Scott R.; Ziemkiewicz, Michael

2017-05-01

The mid-wave infrared (MWIR) portion of the electromagnetic spectrum is critically important for a variety of applications such as LIDAR and chemical sensing. Concerning the latter, the MWIR is often referred to as the "molecular fingerprint" region owing to the fact that many molecules display distinctive vibrational absorptions in this region, making it useful for gas detection. To date, steering MWIR radiation typically required the use of mechanical devices such as gimbals, which are bulky, slow, power-hungry, and subject to mechanical failure. We present the first non-mechanical beam steerer capable of continuous angular tuning in the MWIR. These devices, based on refractive, electro-optic waveguides, provide angular steering in two dimensions without relying on moving parts. Previous work has demonstrated non-mechanical beam steering (NMBS) in the short-wave infrared (SWIR) and near infrared (NIR) using a waveguide in which a portion of the propagating light is evanescently coupled to a liquid crystal (LC) layer in which the refractive index is voltage-tuned. We have extended this NMBS technology into the MWIR by employing chalcogenide glass waveguides and LC materials that exhibit high MWIR transparency. As a result, we have observed continuous, 2D MWIR steering for the first time with a magnitude of 2.74° in-plane and 0.3° out-of-plane.

A Microstrip Patch-Fed Short Backfire Antenna for the Tracking and Data Relay Satellite System-Continuation (TDRSS-C) Multiple Access (MA) Array

NASA Technical Reports Server (NTRS)

Nessel, James A.; Kory, Carol L.; Lambert, Kevin M.; Acosta, Roberto J.

2006-01-01

Short Backfire Antennas (SBAs) are widely utilized for mobile satellite communications, tracking, telemetry, and wireless local area network (WLAN) applications due to their compact structure and excellent radiation characteristics [1-3]. Typically, these SBA s consist of an excitation element (i.e., a half-wavelength dipole), a reflective bottom plane, a planar sub-reflector located above the "exciter", and an outer circular rim. This configuration is capable of achieving gains on the order of 13-15 dBi, but with relatively narrow bandwidths (approx.3%-5%), making it incompatible with the requirements of the next generation enhanced Tracking and Data Relay Satellite System-Continuation (TDRSS-C) Multiple Access (MA) array [1]. Several attempts have been made to enhance the bandwidth performance of the common dipole-fed SBA by employing various other feeding mechanisms (e.g., waveguide, slot) with moderate success [4-5]. In this paper, a novel method of using a microstrip patch is employed for the first time to excite an SBA. The patch element is fed via two H-shaped slots electromagnetically coupled to a broadband hybrid coupler to maintain a wide bandwidth, as well as provide for dual circular polarization capabilities.

Drift-Free Indoor Navigation Using Simultaneous Localization and Mapping of the Ambient Heterogeneous Magnetic Field

NASA Astrophysics Data System (ADS)

Chow, J. C. K.

2017-09-01

In the absence of external reference position information (e.g. surveyed targets or Global Navigation Satellite Systems) Simultaneous Localization and Mapping (SLAM) has proven to be an effective method for indoor navigation. The positioning drift can be reduced with regular loop-closures and global relaxation as the backend, thus achieving a good balance between exploration and exploitation. Although vision-based systems like laser scanners are typically deployed for SLAM, these sensors are heavy, energy inefficient, and expensive, making them unattractive for wearables or smartphone applications. However, the concept of SLAM can be extended to non-optical systems such as magnetometers. Instead of matching features such as walls and furniture using some variation of the Iterative Closest Point algorithm, the local magnetic field can be matched to provide loop-closure and global trajectory updates in a Gaussian Process (GP) SLAM framework. With a MEMS-based inertial measurement unit providing a continuous trajectory, and the matching of locally distinct magnetic field maps, experimental results in this paper show that a drift-free navigation solution in an indoor environment with millimetre-level accuracy can be achieved. The GP-SLAM approach presented can be formulated as a maximum a posteriori estimation problem and it can naturally perform loop-detection, feature-to-feature distance minimization, global trajectory optimization, and magnetic field map estimation simultaneously. Spatially continuous features (i.e. smooth magnetic field signatures) are used instead of discrete feature correspondences (e.g. point-to-point) as in conventional vision-based SLAM. These position updates from the ambient magnetic field also provide enough information for calibrating the accelerometer bias and gyroscope bias in-use. The only restriction for this method is the need for magnetic disturbances (which is typically not an issue for indoor environments); however, no assumptions are required for the general motion of the sensor (e.g. static periods).

Imaging the internal structure of fluid upflow zones with detailed digital Parasound echosounder surveys

NASA Astrophysics Data System (ADS)

Spiess, V.; Zuehlsdorff, L.; von Lom-Keil, H.; Schwenk, T.

2001-12-01

Sites of venting fluids both with continuous and episodic supply often reveal complex surface and internal structures, which are difficult to image and cause problems to transfer results from local sampling towards a structural reconstruction and a quantification of (average) flux rates. Detailed acoustic and seismic surveys would be required to retrieve this information, but also an appropriate environment, where fluid migration can be properly imaged from contrasts to unaffected areas. Hemipelagic sediments are most suitable, since typically reflectors are coherent and of low lateral amplitude variation and structures are continuous over distances much longer than the scale of fluid migration features. During RV Meteor Cruise M473 and RV Sonne Cruise SO 149 detailed studies were carried out in the vicinity of potential fluid upflow zones in the Lower Congo Basin at 5oS in 3000 m water depth and at the Northern Cascadia Margin in 1000 m water depth. Unexpected sampling of massive gas hydrates from the sea floor as well as of carbonate concretions, shell fragments and different liveforms indicated active fluid venting in a typically hemipelagic realm. The acoustic signature of such zones includes columnar blanking, pockmark depressions at the sea floor, association with small offset faults (< 1m). A dedicated survey with closely spaced grid lines was carried out with the Parasound sediment echosounder (4 kHz), which data were digitally acquired with the ParaDigMA System for further processing and display, to image the spatial structure of the upflow zones. Due to the high data density amplitudes and other acoustic properties could be investigated in a 3D volume and time slices as well as reflector surfaces were analyzed. Pronounced lateral variations of reflection amplitudes within a complex pattern indicate potential pathways for fluid/gas migration and occurrences of near-surface gas hydrate deposits, which may be used to trace detailed surface evidence from side scan sonar imaging down to depth and support dedicated sampling.

Algorithms for optimization of branching gravity-driven water networks

NASA Astrophysics Data System (ADS)

Dardani, Ian; Jones, Gerard F.

2018-05-01

The design of a water network involves the selection of pipe diameters that satisfy pressure and flow requirements while considering cost. A variety of design approaches can be used to optimize for hydraulic performance or reduce costs. To help designers select an appropriate approach in the context of gravity-driven water networks (GDWNs), this work assesses three cost-minimization algorithms on six moderate-scale GDWN test cases. Two algorithms, a backtracking algorithm and a genetic algorithm, use a set of discrete pipe diameters, while a new calculus-based algorithm produces a continuous-diameter solution which is mapped onto a discrete-diameter set. The backtracking algorithm finds the global optimum for all but the largest of cases tested, for which its long runtime makes it an infeasible option. The calculus-based algorithm's discrete-diameter solution produced slightly higher-cost results but was more scalable to larger network cases. Furthermore, the new calculus-based algorithm's continuous-diameter and mapped solutions provided lower and upper bounds, respectively, on the discrete-diameter global optimum cost, where the mapped solutions were typically within one diameter size of the global optimum. The genetic algorithm produced solutions even closer to the global optimum with consistently short run times, although slightly higher solution costs were seen for the larger network cases tested. The results of this study highlight the advantages and weaknesses of each GDWN design method including closeness to the global optimum, the ability to prune the solution space of infeasible and suboptimal candidates without missing the global optimum, and algorithm run time. We also extend an existing closed-form model of Jones (2011) to include minor losses and a more comprehensive two-part cost model, which realistically applies to pipe sizes that span a broad range typical of GDWNs of interest in this work, and for smooth and commercial steel roughness values.

Performance monitoring in nicotine dependence: Considering integration of recent reinforcement history.

PubMed

Butler, Kevin; Rusted, Jennifer; Gard, Paul; Jackson, Anne

2017-05-01

Impaired monitoring of errors and conflict (performance monitoring; PM) is well documented in substance dependence (SD) including nicotine dependence and may contribute to continued drug use. Contemporary models of PM and complementary behavioural evidence suggest that PM works by integrating recent reinforcement history rather than evaluating individual behaviours. Despite this, studies of PM in SD have typically used indices derived from reaction to task error or conflict on individual trials. Consequently impaired integration of reinforcement history during action selection tasks requiring behavioural control in SD populations has been underexplored. A reinforcement learning task assessed the ability of abstinent, satiated, former and never smokers (N=60) to integrate recent reinforcement history alongside a more typical behavioural index of PM reflecting the degree of reaction time slowing following an error (post-punishment slowing; PPS). On both indices there was a consistent pattern in PM data: Former smokers had the greatest and satiated smokers the poorest PM. Specifically satiated smokers had poorer reinforcement integration than former (p=0.005) and never smokers (p=0.041) and had less post-punishment slowing than former (p<0.001), never (p=0.003) and abstinent smokers (p=0.026). These are the first data examining the effects of smoking status on PM that use an integration of reinforcement history metric. The concordance of the reinforcement integration and PPS data suggest that this could be a promising method to interrogate PM in future studies. PM is influenced by smoking status. As PM is associated with adapting behaviour, poor PM in satiated smokers may contribute towards continued smoking despite negative consequences. Former smokers show elevated PM suggesting this may be a good relapse prevention target for individuals struggling to remain abstinent however prospective and intervention studies are needed. A better understanding of PM deficits in terms of reinforcement integration failure may stimulate development of novel treatment approaches. Copyright © 2017 Elsevier Inc. All rights reserved.

Robot-aided developmental assessment of wrist proprioception in children.

PubMed

Marini, Francesca; Squeri, Valentina; Morasso, Pietro; Campus, Claudio; Konczak, Jürgen; Masia, Lorenzo

2017-01-09

Several neurodevelopmental disorders and brain injuries in children have been associated with proprioceptive dysfunction that will negatively affect their movement. Unfortunately, there is lack of reliable and objective clinical examination protocols and our current knowledge of how proprioception evolves in typically developing children is still sparse. Using a robotic exoskeleton, we investigated proprioceptive acuity of the wrist in a group of 49 typically developing healthy children (8-15 years), and a group of 40 young adults. Without vision participants performed an ipsilateral wrist joint position matching task that required them to reproduce (match) a previously experienced target position. All three joint degrees-of-freedom of the wrist/hand complex were assessed. Accuracy and precision were evaluated as a measure of proprioceptive acuity. The cross-sectional data indicating the time course of development of acuity were then fitted by four models in order to determine which function best describes developmental changes in proprioception across age. First, the robot-aided assessment proved to be an easy to administer method for objectively measuring proprioceptive acuity in both children and adult populations. Second, proprioceptive acuity continued to develop throughout middle childhood and early adolescence, improving by more than 50% with respect to the youngest group. Adult levels of performance were reached approximately by the age of 12 years. An inverse-root function best described the development of proprioceptive acuity across the age groups. Third, wrist/forearm proprioception is anisotropic across the three DoFs with the Abduction/Adduction exhibiting a higher level of acuity than those of Flexion/extension and Pronation/Supination. This anisotropy did not change across development. Proprioceptive development for the wrist continues well into early adolescence. Our normative data obtained trough this novel robot-aided assessment method provide a basis against which proprioceptive function of pediatric population can be compared. This may aid the design of more effective sensorimotor intervention programs.

Pulsed Dose Radiofrequency Before Ablation of Medial Branch of the Lumbar Dorsal Ramus for Zygapophyseal Joint Pain Reduces Post-procedural Pain.

PubMed

Arsanious, David; Gage, Emmanuel; Koning, Jonathon; Sarhan, Mazin; Chaiban, Gassan; Almualim, Mohammed; Atallah, Joseph

2016-01-01

One of the potential side effects with radiofrequency ablation (RFA) includes painful cutaneous dysesthesias and increased pain due to neuritis or neurogenic inflammation. This pain may require the prescription of opioids or non-opioid analgesics to control post-procedural pain and discomfort. The goal of this study is to compare post-procedural pain scores and post-procedural oral analgesic use in patients receiving continuous thermal radiofrequency ablation versus patients receiving pulsed dose radiofrequency immediately followed by continuous thermal radiofrequency ablation for zygopophaseal joint disease. This is a prospective, double-blinded, randomized, controlled trial. Patients who met all the inclusion criteria and were not subject to any of the exclusion criteria were required to have two positive diagnostic medial branch blocks prior to undergoing randomization, intervention, and analysis. University hospital. Eligible patients were randomized in a 1:1 ratio to either receive thermal radiofrequency ablation alone (standard group) or pulsed dose radiofrequency (PDRF) immediately followed by thermal radiofrequency ablation (investigational group), all of which were performed by a single Board Certified Pain Medicine physician. Post-procedural pain levels between the two groups were assessed using the numerical pain Scale (NPS), and patients were contacted by phone on post-procedural days 1 and 2 in the morning and afternoon regarding the amount of oral analgesic medications used in the first 48 hours following the procedure. Patients who received pulsed dose radiofrequency followed by continuous radiofrequency neurotomy reported statistically significantly lower post-procedural pain scores in the first 24 hours compared to patients who received thermal radiofrequency neurotomy alone. These patients also used less oral analgesic medication in the post-procedural period. These interventions were carried out by one board accredited pain physician at one center. The procedures were exclusively performed using one model of radiofrequency generator, at one setting for the PDRF and RFA. The difference in the number of levels of ablation was not considered in the analysis of the results. Treating patients with pulsed dose radiofrequency prior to continuous thermal radiofrequency ablation can provide patients with less post-procedural pain during the first 24 hours and also reduce analgesic requirements. Furthermore, the addition of PDRF to standard thermal RFA did not prolong the time of standard thermal radiofrequency ablation procedures, as it was performed during the typically allotted time for local anesthetic action. Low back pain, facet joint disease, medial branch block, Radiofrequency ablation, thermal radiofrequency, pulsed dose radiofrequency, PDRF, zygapophyseal joint.

40 CFR 63.9632 - What are the installation, operation, and maintenance requirements for my monitoring equipment?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Taconite Iron Ore Processing Continuous Compliance Requirements § 63.9632 What are...

40 CFR 63.9632 - What are the installation, operation, and maintenance requirements for my monitoring equipment?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants: Taconite Iron Ore Processing Continuous Compliance Requirements § 63.9632 What are...

Training Pathology Residents to Practice 21st Century Medicine

PubMed Central

Black-Schaffer, W. Stephen; Morrow, Jon S.; Steinberg, Jacob J.

2016-01-01

Scientific advances, open information access, and evolving health-care economics are disrupting extant models of health-care delivery. Physicians increasingly practice as team members, accountable to payers and patients, with improved efficiency, value, and quality. This change along with a greater focus on population health affects how systems of care are structured and delivered. Pathologists are not immune to these disruptors and, in fact, may be one of the most affected medical specialties. In the coming decades, it is likely that the number of practicing pathologists will decline, requiring each pathologist to serve more and often sicker patients. The demand for increasingly sophisticated yet broader diagnostic skills will continue to grow. This will require pathologists to acquire appropriate professional training and interpersonal skills. Today’s pathology training programs are ill designed to prepare such practitioners. The time to practice for most pathology trainees is typically 5 to 6 years. Yet, trainees often lack sufficient experience to practice independently and effectively. Many studies have recognized these challenges suggesting that more effective training for this new century can be implemented. Building on the strengths of existing programs, we propose a redesign of pathology residency training that will meet (and encourage) a continuing evolution of American Board of Pathology and Accreditation Council for Graduate Medical Education requirements, reduce the time to readiness for practice, and produce more effective, interactive, and adaptable pathologists. The essence of this new model is clear definition and acquisition of core knowledge and practice skills that span the anatomic and clinical pathology continuum during the first 2 years, assessed by competency-based metrics with emphasis on critical thinking and skill acquisition, followed by individualized modular training with intensively progressive responsibility during the final years of training. We anticipate that implementing some or all aspects of this model will enable residents to attain a higher level of competency within the current time-based constraints of residency training. PMID:28725776

Training Pathology Residents to Practice 21st Century Medicine: A Proposal.

PubMed

Black-Schaffer, W Stephen; Morrow, Jon S; Prystowsky, Michael B; Steinberg, Jacob J

2016-01-01

Scientific advances, open information access, and evolving health-care economics are disrupting extant models of health-care delivery. Physicians increasingly practice as team members, accountable to payers and patients, with improved efficiency, value, and quality. This change along with a greater focus on population health affects how systems of care are structured and delivered. Pathologists are not immune to these disruptors and, in fact, may be one of the most affected medical specialties. In the coming decades, it is likely that the number of practicing pathologists will decline, requiring each pathologist to serve more and often sicker patients. The demand for increasingly sophisticated yet broader diagnostic skills will continue to grow. This will require pathologists to acquire appropriate professional training and interpersonal skills. Today's pathology training programs are ill designed to prepare such practitioners. The time to practice for most pathology trainees is typically 5 to 6 years. Yet, trainees often lack sufficient experience to practice independently and effectively. Many studies have recognized these challenges suggesting that more effective training for this new century can be implemented. Building on the strengths of existing programs, we propose a redesign of pathology residency training that will meet (and encourage) a continuing evolution of American Board of Pathology and Accreditation Council for Graduate Medical Education requirements, reduce the time to readiness for practice, and produce more effective, interactive, and adaptable pathologists. The essence of this new model is clear definition and acquisition of core knowledge and practice skills that span the anatomic and clinical pathology continuum during the first 2 years, assessed by competency-based metrics with emphasis on critical thinking and skill acquisition, followed by individualized modular training with intensively progressive responsibility during the final years of training. We anticipate that implementing some or all aspects of this model will enable residents to attain a higher level of competency within the current time-based constraints of residency training.

Use of electroluminescence technology for highway signage.

DOT National Transportation Integrated Search

2001-09-30

Laboratory work will be combined with reviews of highway signage protocols, requirements and : potential applications that will lead to prototype design requirements for a typical highway sign that : should have the potential to improve safety for th...

Mapping of multiple parameter m-health scenarios to mobile WiMAX QoS variables.

PubMed

Alinejad, Ali; Philip, N; Istepanian, R S H

2011-01-01

Multiparameter m-health scenarios with bandwidth demanding requirements will be one of key applications in future 4 G mobile communication systems. These applications will potentially require specific spectrum allocations with higher quality of service requirements. Furthermore, one of the key 4 G technologies targeting m-health will be medical applications based on WiMAX systems. Hence, it is timely to evaluate such multiple parametric m-health scenarios over mobile WiMAX networks. In this paper, we address the preliminary performance analysis of mobile WiMAX network for multiparametric telemedical scenarios. In particular, we map the medical QoS to typical WiMAX QoS parameters to optimise the performance of these parameters in typical m-health scenario. Preliminary performance analyses of the proposed multiparametric scenarios are evaluated to provide essential information for future medical QoS requirements and constraints in these telemedical network environments.

An integrated power/attitude control system /IPACS/ for space vehicle application

NASA Technical Reports Server (NTRS)

Anderson, W. W.; Keckler, C. R.

1973-01-01

An integrated power and attitude control system (IPACS) concept with potential application to a broad class of space missions is discussed. The concept involves the storage and supply on demand of electrical energy in rotating flywheels while simultaneously providing control torques by controlled precession of the flywheels. The system is thus an alternative to the storage batteries used on present spacecraft while providing similar capability for attitude control as that represented by a control moment gyroscope (CMG) system. Potential IPACS configurations discussed include single- and double-rotor double-gimbal IPACS units. Typical sets of control laws which would manage the momentum and energy exchange between the IPACS and a typical space vehicle are discussed. Discussion of a simulation of a typical potential IPACS configuration and candidate mission concerned with pointing capability, power supply and demand flow, and discussion of the interactions between stabilization and control requirements and power flow requirements are presented.

40 CFR Table 10 to Subpart Wwww of... - Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUE...

40 CFR Table 10 to Subpart Wwww of... - Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUE...

40 CFR Table 10 to Subpart Wwww of... - Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Data Requirements for New and Existing Continuous Lamination Lines and Continuous Casting Lines Complying With a Percent Reduction Limit on a Per Line Basis 10 Table 10 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUE...

Phase plate technology for laser marking of magnetic discs

DOEpatents

Neuman, B.; Honig, J.; Hackel, L.; Dane, C.B.; Dixit, S.

1998-10-27

An advanced design for a phase plate enables the distribution of spots in arbitrarily shaped patterns with very high uniformity and with a continuously or near-continuously varying phase pattern. A continuous phase pattern eliminates large phase jumps typically expected in a grating that provides arbitrary shapes. Large phase jumps increase scattered light outside of the desired pattern, reduce efficiency and can make the grating difficult to manufacture. When manufacturing capabilities preclude producing a fully continuous grating, the present design can be easily adapted to minimize manufacturing errors and maintain high efficiencies. This continuous grating is significantly more efficient than previously described Dammann gratings, offers much more flexibility in generating spot patterns and is easier to manufacture and replicate than a multi-level phase grating. 3 figs.

40 CFR 60.2710 - How do I demonstrate continuous compliance with the amended emission limitations and the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF... Solid Waste Incineration Units Model Rule-Continuous Compliance Requirements § 60.2710 How do I...) Compliance with standards. (1) The emission standards and operating requirements set forth in this subpart...

40 CFR 60.2710 - How do I demonstrate continuous compliance with the amended emission limitations and the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF... Solid Waste Incineration Units Model Rule-Continuous Compliance Requirements § 60.2710 How do I...) Compliance with standards. (1) The emission standards and operating requirements set forth in this subpart...

75 FR 2562 - Publication of Model Notices for Health Care Continuation Coverage Provided Pursuant to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... Health Care Continuation Coverage Provided Pursuant to the Consolidated Omnibus Budget Reconciliation Act (COBRA) and Other Health Care Continuation Coverage, as Required by the American Recovery and... Availability of the Model Health Care Continuation Coverage Notices Required by ARRA, as amended. SUMMARY: On...

40 CFR Table 6 to Subpart Jjj of... - Requirements for Validating Continuous Emission Monitoring Systems (CEMS)

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Requirements for Validating Continuous Emission Monitoring Systems (CEMS) 6 Table 6 to Subpart JJJ of Part 62 Protection of Environment... of Part 62—Requirements for Validating Continuous Emission Monitoring Systems (CEMS) ER31JA03.012 ...

40 CFR Table 4 to Subpart Ffff of... - Model Rule-Requirements for Continuous Emission Monitoring Systems (CEMS)

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Model Rule-Requirements for Continuous Emission Monitoring Systems (CEMS) 4 Table 4 to Subpart FFFF of Part 60 Protection of Environment...—Model Rule—Requirements for Continuous Emission Monitoring Systems (CEMS) As stated in § 60.3039, you...

40 CFR Table 4 to Subpart Ffff of... - Model Rule-Requirements for Continuous Emission Monitoring Systems (CEMS)

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Model Rule-Requirements for Continuous Emission Monitoring Systems (CEMS) 4 Table 4 to Subpart FFFF of Part 60 Protection of Environment...—Model Rule—Requirements for Continuous Emission Monitoring Systems (CEMS) As stated in § 60.3039, you...

40 CFR Table 6 to Subpart Jjj of... - Requirements for Validating Continuous Emission Monitoring Systems (CEMS)

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Requirements for Validating Continuous Emission Monitoring Systems (CEMS) 6 Table 6 to Subpart JJJ of Part 62 Protection of Environment... of Part 62—Requirements for Validating Continuous Emission Monitoring Systems (CEMS) ER31JA03.012 ...

Neural source dynamics of brain responses to continuous stimuli: Speech processing from acoustics to comprehension.

PubMed

Brodbeck, Christian; Presacco, Alessandro; Simon, Jonathan Z

2018-05-15

Human experience often involves continuous sensory information that unfolds over time. This is true in particular for speech comprehension, where continuous acoustic signals are processed over seconds or even minutes. We show that brain responses to such continuous stimuli can be investigated in detail, for magnetoencephalography (MEG) data, by combining linear kernel estimation with minimum norm source localization. Previous research has shown that the requirement to average data over many trials can be overcome by modeling the brain response as a linear convolution of the stimulus and a kernel, or response function, and estimating a kernel that predicts the response from the stimulus. However, such analysis has been typically restricted to sensor space. Here we demonstrate that this analysis can also be performed in neural source space. We first computed distributed minimum norm current source estimates for continuous MEG recordings, and then computed response functions for the current estimate at each source element, using the boosting algorithm with cross-validation. Permutation tests can then assess the significance of individual predictor variables, as well as features of the corresponding spatio-temporal response functions. We demonstrate the viability of this technique by computing spatio-temporal response functions for speech stimuli, using predictor variables reflecting acoustic, lexical and semantic processing. Results indicate that processes related to comprehension of continuous speech can be differentiated anatomically as well as temporally: acoustic information engaged auditory cortex at short latencies, followed by responses over the central sulcus and inferior frontal gyrus, possibly related to somatosensory/motor cortex involvement in speech perception; lexical frequency was associated with a left-lateralized response in auditory cortex and subsequent bilateral frontal activity; and semantic composition was associated with bilateral temporal and frontal brain activity. We conclude that this technique can be used to study the neural processing of continuous stimuli in time and anatomical space with the millisecond temporal resolution of MEG. This suggests new avenues for analyzing neural processing of naturalistic stimuli, without the necessity of averaging over artificially short or truncated stimuli. Copyright © 2018 Elsevier Inc. All rights reserved.

Advanced High-Power Generator Research Program

DTIC Science & Technology

1986-05-01

lOOx ............. ... 3A-6 3A-3 Carbides in the Inconel are Well Broken Up. No Continuous Networks as in Previous Bonds. Unetched. Magnified 225X.. 3A...7 3A-4 Carbides in the Inconel are Well Broken Uo. No Continuous Networks as in Previous Bonds. Unetched. Magnified 225X.. 3A-7 3A-5 Carbides are Well...3A-9 3A-8 Typical Tensile Rupture. Failure Occurred with Inconel 718 Carbide Precipitation Zone. Magnified 225X

Continuous-flow retro-Diels-Alder reaction: an efficient method for the preparation of pyrimidinone derivatives.

PubMed

Nekkaa, Imane; Palkó, Márta; Mándity, István M; Fülöp, Ferenc

2018-01-01

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.

41 CFR 102-36.35 - What is the typical process for disposing of excess personal property?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is the typical... agency property or by obtaining excess property from other federal agencies in lieu of new procurements... eligible non-federal activities. Title 40 of the United States Code requires that surplus personal property...

PERSONAL-PRACTICES POLLUTANTS: UBIETY, UBIQUITY, SIGNIFICANCE, SOLUTIONS, STEWARDSHIP

EPA Science Inventory

The occurrence of pharmaceuticals and personal care products (PPCPS) as environmental pollutants is a multifaceted issue whose scope continues to become better delineated with the escalation of attention that began in the 1980s. PPCPs typically occur as trace environmental pollut...

Arctic Haze: Natural or Pollution?

DTIC Science & Technology

1986-11-01

Northeastern China . ..........................................24 APPLICATIONS OF THE TRACER SYSTEM 15. Sources of Arctic haze during a typical winter...Soviet Union ........................ 62 - 10. Continued cooperation with China .................................. 62 11. Eastern European signatures via...the Western Soviet Union, Northeastern China , Southwestern China , and Manchuria. 2- . 1. _40

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS: DIVERSE GALAXY OF ENVIRONMENTAL POLLUTANTS

EPA Science Inventory

The occurrence of pharmaceuticals and personal care products (PPCPs) as trace environmental pollutants is a multifaceted issue whose scope of concerns continues to expand. PPCPs comprise thousands of distinct chemicals from numerous therapeutic and consumer classes. They typical...

[Christmas from an allergist's perspective].

PubMed

Wedi, Bettina

2016-12-01

The customs and traditions associated with Christmas may result in allergic reactions to allergens that are typical for this period. On the one hand the rise in prevalence of allergic diseases has continued in the industrialized world for the last decades and allergies are regarded as widespread diseases. On the other hand the 21th century is a time of "allergy delusion". This review summarizes the facts about allergic reactions to Christmas typical decoration, food and behavior. Taken together, allergic reactions to Christmas tree, poinsettia, Christmas cactus, perfumed candles, Christmas typical food, common gifts like mobile phones and laptops, frankincense, myrrh and pollens have been described but in very rare instances. The chance to survive Christmas without allergic symptoms is high, particularly for non-atopics. © Georg Thieme Verlag KG Stuttgart · New York.

40 CFR 271.10 - Requirements for generators of hazardous wastes.

Code of Federal Regulations, 2012 CFR

2012-07-01

... hazardous wastes. 271.10 Section 271.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) REQUIREMENTS FOR AUTHORIZATION OF STATE HAZARDOUS WASTE PROGRAMS Requirements for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State...

40 CFR 271.11 - Requirements for transporters of hazardous wastes.

Code of Federal Regulations, 2012 CFR

2012-07-01

... hazardous wastes. 271.11 Section 271.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) REQUIREMENTS FOR AUTHORIZATION OF STATE HAZARDOUS WASTE PROGRAMS Requirements for Final Authorization § 271.11 Requirements for transporters of hazardous wastes. (a) The State...

40 CFR 271.11 - Requirements for transporters of hazardous wastes.

Code of Federal Regulations, 2013 CFR

2013-07-01

... hazardous wastes. 271.11 Section 271.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) REQUIREMENTS FOR AUTHORIZATION OF STATE HAZARDOUS WASTE PROGRAMS Requirements for Final Authorization § 271.11 Requirements for transporters of hazardous wastes. (a) The State...

40 CFR 271.10 - Requirements for generators of hazardous wastes.

Code of Federal Regulations, 2013 CFR

2013-07-01

... hazardous wastes. 271.10 Section 271.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) REQUIREMENTS FOR AUTHORIZATION OF STATE HAZARDOUS WASTE PROGRAMS Requirements for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State...

40 CFR 271.10 - Requirements for generators of hazardous wastes.

Code of Federal Regulations, 2011 CFR

2011-07-01

... hazardous wastes. 271.10 Section 271.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) REQUIREMENTS FOR AUTHORIZATION OF STATE HAZARDOUS WASTE PROGRAMS Requirements for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State...

14 CFR § 1216.306 - Actions normally requiring an EIS.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) § 1216.306 Actions normally requiring an EIS. (a) NASA will prepare an EIS for actions with the potential...) Typical NASA actions normally requiring an EIS include: (1) Development and operation of new launch... using a total quantity of radioactive material greater than the quantity for which the NASA Nuclear...