Competing collinear and noncollinear interactions in chirped quasi-phase-matched optical parametric amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charbonneau-Lefort, Mathieu; Afeyan, Bedros; Fejer, M. M.

Chirped quasi-phase-matched optical parametric amplifiers (chirped QPM OPAs) are investigated experimentally. The measured collinear gain is constant over a broad bandwidth, which makes these devices attractive candidates for use in femtosecond amplifier systems. The experiment also shows that chirped QPM OPAs support noncollinear gain-guided modes. These modes can dominate the desired collinear gain and generate intense parametric fluorescence. Finally, design guidelines to mitigate these parasitic processes are discussed.

Dana-Farber Cancer Institute: Discovery of Novel Oncogenes | Office of Cancer Genomics

Cancer.gov

Widespread recurrent copy number alterations are observed across the majority of human cancers, yet the specific targets of such amplified or deleted regions remain undefined. Here, the CTD2 Center at the Dana Farber Cancer Institute took a systematic approach using cDNA overexpression screening to identify and validate oncogenes residing in such amplified regions. In representative examples, these experiments have identified the adaptor proteins CRKL, GAB2, FRS2 and the TLOC and SKIL proteins as novel amplified oncogenes.

Proceedings of the International Conference on Lasers 󈨝 (12th), Held in New Orleans, Louisiana on December 3-8, 1989.

DTIC Science & Technology

1990-01-01

schedule soon, while in the percutaneous one auto-fluorescence spectroscopy could be the closest technique to be effectively included in the angioplasty...experiments Dashed line: Amplifier mode experiments ( scheduled ) Fig. 3 Schematic of laser, pulsed power, and X-ray preionizer 3. Pulsed Power 4. X-Ray...of KrF Amplifier * scheduled ** estimated value 120 CONDENSED PHASE RARE GAS HALIDE EXCIPLEX LASERS V. Ara Apkarian Professor of Chemistry Department

Theory, Design and Operation of a High-Power Second - Gyro-Twt Amplifier.

NASA Astrophysics Data System (ADS)

Wang, Qinsong

1995-01-01

Based on the cyclotron resonance maser (CRM) instability, the gyrotron traveling wave tube (gyro-TWT) amplifier is an efficient high power microwave and millimeter wave coherent radiation source. As evidenced in previous experiments, gyro-TWTs, however, can be very susceptible to spontaneous oscillations, and their output powers have thus been limited to relatively low levels. In this dissertation work, thorough theoretical and experimental studies have been conducted to demonstrate and confirm a novel "marginal stability design" (MSD) concept that a harmonic gyro-TWT amplifier is more stable to spontaneous oscillation than a fundamental harmonic gyro-TWT amplifier. Since their interactions are, in general, weaker and allow higher levels of electron beam current, harmonic gyro-TWTs can yield, in principle, a significantly higher RF output power than a fundamental gyro-TWT. The study results also show that a magnetron injection gun (MIG) type electron beam is applicable to harmonic gyro-TWTs. A complete analytic linear theory employing Laplace transforms and a three dimensional nonlinear theory using a slow time-scale formalism are developed in Chapt. 2 for the general CRM interaction to address the issue of stability. Two designs were developed to demonstrate the MSD procedure. The design and development of the proof -of-principle experiment are discussed in Chapt. 3. The accompanying cold test results indicate that all the components have met their respective design goals. The RF diagnostic circuit employed to characterize the gyro-TWT amplifier is also described. Chapter 4 presents the hot-test results of the second-harmonic TE_{21} gyro-TWT amplifier experiment in which an 80 kV, 20 A MIG beam with alpha(equivupsilon _|/upsilon_|) = 1 was used to generate a peak RF output power of 207 kW in Ku-band with an efficiency of 12.9%. In addition, the saturated gain is 16 dB, the small signal gain is 22 dB, the measured bandwidth is 2.1%, and the amplifier was zero-drive stable. As pointed out in Chapt. 5, the theoretical and experimental studies conducted in this work have successfully realized their objectives. Further improvements to the current proof-of-principle experiment and an increase in the operating frequency by operating at an even higher cyclotron harmonic are promising and worthy of future efforts.

ILLUMA-T (Integrated LCRD LEO User Modem and Amplifier Terminal) Payload

NASA Technical Reports Server (NTRS)

Seas, Antonios; Gonnsen, Zachary; Yarnall, Timothy

2018-01-01

Presentation on ILLUMA-T (Integrated LCRD LEO User Modem and Amplifier Terminal) Payload at the Japanese Experiment Module (JEM) External Payload Interface Coordination Meeting on May 9, 2018 at the Japan Aerospace Exploration Agency (JAXA) in Tsukuba, Japan. Meeting to discuss details of installing payload on JEM.

A Low-Voltage Chopper-Stabilized Amplifier for Fetal ECG Monitoring With a 1.41 Power Efficiency Factor.

PubMed

Song, Shuang; Rooijakkers, Michael; Harpe, Pieter; Rabotti, Chiara; Mischi, Massimo; van Roermund, Arthur H M; Cantatore, Eugenio

2015-04-01

This paper presents a low-voltage current-reuse chopper-stabilized frontend amplifier for fetal ECG monitoring. The proposed amplifier allows for individual tuning of the noise in each measurement channel, minimizing the total power consumption while satisfying all application requirements. The low-voltage current reuse topology exploits power optimization in both the current and the voltage domain, exploiting multiple supply voltages (0.3, 0.6 and 1.2 V). The power management circuitry providing the different supplies is optimized for high efficiency (peak charge-pump efficiency = 90%).The low-voltage amplifier together with its power management circuitry is implemented in a standard 0.18 μm CMOS process and characterized experimentally. The amplifier core achieves both good noise efficiency factor (NEF=1.74) and power efficiency factor (PEF=1.05). Experiments show that the amplifier core can provide a noise level of 0.34 μVrms in a 0.7 to 182 Hz band, consuming 1.17 μW power. The amplifier together with its power management circuitry consumes 1.56 μW, achieving a PEF of 1.41. The amplifier is also validated with adult ECG and pre-recorded fetal ECG measurements.

A Novel Terminator Primer and Enhancer Reagents for Direct Expression of PCR-Amplified Genes in Mammalian Cells.

PubMed

Nakamura, Mikiko; Suzuki, Ayako; Akada, Junko; Yarimizu, Tohru; Iwakiri, Ryo; Hoshida, Hisashi; Akada, Rinji

2015-08-01

Escherichia coli plasmids are commonly used for gene expression experiments in mammalian cells, while PCR-amplified DNAs are rarely used even though PCR is a much faster and easier method to construct recombinant DNAs. One difficulty may be the limited amount of DNA produced by PCR. For direct utilization of PCR-amplified DNA in transfection experiments, efficient transfection with a smaller amount of DNA should be attained. For this purpose, we investigated two enhancer reagents, polyethylene glycol and tRNA, for a chemical transfection method. The addition of the enhancers to a commercial transfection reagent individually and synergistically exhibited higher transfection efficiency applicable for several mammalian cell culture lines in a 96-well plate. By taking advantage of a simple transfection procedure using PCR-amplified DNA, SV40 and rabbit β-globin terminator lengths were minimized. The terminator length is short enough to design in oligonucleotides; thus, terminator primers can be used for the construction and analysis of numerous mutations, deletions, insertions, and tag-fusions at the 3'-terminus of any gene. The PCR-mediated gene manipulation with the terminator primers will transform gene expression by allowing for extremely simple and high-throughput experiments with small-scale, multi-well, and mammalian cell cultures.

Simulation of double-pass stimulated Raman backscattering

NASA Astrophysics Data System (ADS)

Wu, Z.; Chen, Q.; Morozov, A.; Suckewer, S.

2018-04-01

Experiments on Stimulated Raman Backscattering (SRBS) in plasma have demonstrated significantly higher energy conversion in a double-pass amplifier where the laser pulses go through the plasma twice compared with a single-pass amplifier with double the plasma length of a single pass. In this paper, the improvement in understanding recent experimental results is presented by considering quite in detail the effects of plasma heating on the modeling of SRBS. Our simulation results show that the low efficiency of single-pass amplifiers can be attributed to Landau damping and the frequency shift of Langmuir waves. In double-pass amplifiers, these issues can be avoided, to some degree, because pump-induced heating could be reduced, while the plasma cools down between the passes. Therefore, double-pass amplifiers yield considerably enhanced energy transfer from the pump to the seed, hence the output pulse intensity.

250W continuous-tunable all-fiberized single-frequency polarization-maintained amplifiers with wavelength spanning from 1065 nm to 1090 nm

NASA Astrophysics Data System (ADS)

Liu, Yakun; Su, Rongtao; Wang, Xiaolin; Ma, Pengfei; Zhang, Hanwei; Si, Lei

2017-10-01

In this manuscript, we demonstrate an all-fiberized, single-frequency and polarization-maintained (PM) amplifiers with wavelength tuned from 1065 nm to 1090 nm. The ASE is suppressed by a signal to noise ratio of higher than 27 dB, and each wavelengths can be amplified to be 250 W output power. The stimulated Brillouin scattering (SBS) effect in such high power amplifiers is suppressed by employing a high dopant fiber (10 dB/m). The polarization extinction ratio (PER) of the amplifier is over 20 dB at the maximum output power. It should be noted that although the experiments are conducted at the wavelength from 1065 nm to 1090 nm with a step of 5 nm, the wavelength can also be continuously tuned.

Reflex ring laser amplifier system

DOEpatents

Summers, M.A.

1983-08-31

The invention is a method and apparatus for providing a reflex ring laser system for amplifying an input laser pulse. The invention is particularly useful in laser fusion experiments where efficient production of high-energy and high power laser pulses is required. The invention comprises a large aperture laser amplifier in an unstable ring resonator which includes a combination spatial filter and beam expander having a magnification greater than unity. An input pulse is injected into the resonator, e.g., through an aperture in an input mirror. The injected pulse passes through the amplifier and spatial filter/expander components on each pass around the ring. The unstable resonator is designed to permit only a predetermined number of passes before the amplified pulse exits the resonator. On the first pass through the amplifier, the beam fills only a small central region of the gain medium. On each successive pass, the beam has been expanded to fill the next concentric non-overlapping region of the gain medium.

On-Ramp: Improving students' understanding of lock-in amplifiers

NASA Astrophysics Data System (ADS)

DeVore, Seth; Singh, Chandralekha; Levy, Jeremy

2013-03-01

A lock-in amplifier is a powerful and versatile instrument which is used frequently in condensed matter physics research. However, many students struggle with the basics of a lock-in amplifier and they have difficulty in interpreting the data obtained with this device in diverse applications. To improve students' understanding, we are developing an ``On-Ramp'' tutorial based on physics education research which makes use of a computer simulation of a lock-in amplifier. During the development of the tutorial we interviewed several faculty members and graduate students. The tutorial is based on a field-tested approach in which students realize their difficulties after predicting the outcome of experiments that use a lock-in amplifier; students can check their predictions using simulations. The tutorial then guides students toward a coherent understanding of the basics of a lock-in amplifier. This poster will discuss the development and assessment process. This work is supported by NSF NEB (DMR-1124131) and NSF (PHY-1202909).

Optical rogue-wave-like extreme value fluctuations in fiber Raman amplifiers.

PubMed

Hammani, Kamal; Finot, Christophe; Dudley, John M; Millot, Guy

2008-10-13

We report experimental observation and characterization of rogue wave-like extreme value statistics arising from pump-signal noise transfer in a fiber Raman amplifier. Specifically, by exploiting Raman amplification with an incoherent pump, the amplified signal is shown to develop a series of temporal intensity spikes whose peak power follows a power-law probability distribution. The results are interpreted using a numerical model of the Raman gain process using coupled nonlinear Schrödinger equations, and the numerical model predicts results in good agreement with experiment.

SQUID-based microwave cavity search for dark-matter axions.

PubMed

Asztalos, S J; Carosi, G; Hagmann, C; Kinion, D; van Bibber, K; Hotz, M; Rosenberg, L J; Rybka, G; Hoskins, J; Hwang, J; Sikivie, P; Tanner, D B; Bradley, R; Clarke, J

2010-01-29

Axions in the microeV mass range are a plausible cold dark-matter candidate and may be detected by their conversion into microwave photons in a resonant cavity immersed in a static magnetic field. We report the first result from such an axion search using a superconducting first-stage amplifier (SQUID) replacing a conventional GaAs field-effect transistor amplifier. This experiment excludes KSVZ dark-matter axions with masses between 3.3 microeV and 3.53 microeV and sets the stage for a definitive axion search utilizing near quantum-limited SQUID amplifiers.

Injection seeded, diode pumped regenerative ring Nd:YAG amplifier for spaceborne laser ranging technology development

NASA Technical Reports Server (NTRS)

Coyle, D. Barry; Kay, Richard B.; Degnan, John J.; Krebs, Danny J.; Seery, Bernard D.

1992-01-01

A small, all solid state, regenerative ring amplifier designed as a prototype for space application is discussed. Novel features include dual side pumping of the Nd:YAG crystal and a triangular ring cavity design which minimizes the number of optical components and losses. The amplifier is relatively small (3 ns round trip time) even though standard optical elements are employed. The ring regeneratively amplifies a 100 ps single pulse by approximately 10(exp 5) at a repetition rate of 10 to 100 Hz. The amplifier is designed to be injection seeded with a pulsed, 100 ps laser diode at 1.06 microns, but another Nd:YAG laser system supplying higher pulse energies was employed for laboratory experiment. This system is a prototype laser oscillator for the Geoscience Laser Ranging System (GLRS) platform. Results on measurements of beam quality, astigmatism, and gain are given.

X-band inverse class-F GaN internally-matched power amplifier

NASA Astrophysics Data System (ADS)

Zhao, Bo-Chao; Lu, Yang; Han, Wen-Zhe; Zheng, Jia-Xin; Zhang, Heng-Shuang; Ma, Pei-jun; Ma, Xiao-Hua; Hao, Yue

2016-09-01

An X-band inverse class-F power amplifier is realized by a 1-mm AlGaN/GaN high electron mobility transistor (HEMT). The intrinsic and parasitic components inside the transistor, especially output capacitor Cds, influence the harmonic impedance heavily at the X-band, so compensation design is used for meeting the harmonic condition of inverse class-F on the current source plane. Experiment results show that, in the continuous-wave mode, the power amplifier achieves 61.7% power added efficiency (PAE), which is 16.3% higher than the class-AB power amplifier realized by the same kind of HEMT. To the best of our knowledge, this is the first inverse class-F GaN internally-matched power amplifier, and the PAE is quite high at the X-band. Project supported by the National High Technology Research and Development Program of China (Grant No. 2015AA016801).

Sub-MW peak power diffraction-limited chirped-pulse monolithic Yb-doped tapered fiber amplifier.

PubMed

Bobkov, Konstantin; Andrianov, Alexey; Koptev, Maxim; Muravyev, Sergey; Levchenko, Andrei; Velmiskin, Vladimir; Aleshkina, Svetlana; Semjonov, Sergey; Lipatov, Denis; Guryanov, Alexey; Kim, Arkady; Likhachev, Mikhail

2017-10-30

We demonstrate a novel amplification regime in a counter-pumped, relatively long (2 meters), large mode area, highly Yb-doped and polarization-maintaining tapered fiber, which offers a high peak power directly from the amplifier. The main feature of this regime is that the amplifying signal propagates through a thin part of the tapered fiber without amplification and experiences an extremely high gain in the thick part of the tapered fiber, where most of the pump power is absorbed. In this regime, we have demonstrated 8 ps pulse amplification to a peak power of up to 0.76 MW, which is limited by appearance of stimulated Raman scattering. In the same regime, 28 ps chirped pulses are amplified to a peak power of 0.35 MW directly from the amplifier and then compressed with 70% efficiency to 315 ± 10 fs, corresponding to an estimated peak power of 22 MW.

Implantable neurotechnologies: a review of integrated circuit neural amplifiers.

PubMed

Ng, Kian Ann; Greenwald, Elliot; Xu, Yong Ping; Thakor, Nitish V

2016-01-01

Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification.

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

PubMed Central

Greenwald, Elliot; Xu, Yong Ping; Thakor, Nitish V.

2016-01-01

Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification. PMID:26798055

Amplifying Student Learning through Volunteering

ERIC Educational Resources Information Center

McFadden, Amanda; Smeaton, Kathleen

2017-01-01

Student volunteer experiences are ubiquitous within higher education contexts. Despite this, there is further scope for understanding the qualitatively different ways students experience volunteering. To achieve this an explicit focus on understanding volunteer experiences from the students' perspective and the relationship these experiences have…

Quantum nondemolition readout using a Josephson bifurcation amplifier

NASA Astrophysics Data System (ADS)

Boulant, N.; Ithier, G.; Meeson, P.; Nguyen, F.; Vion, D.; Esteve, D.; Siddiqi, I.; Vijay, R.; Rigetti, C.; Pierre, F.; Devoret, M.

2007-07-01

We report an experiment on the determination of the quantum nondemolition (QND) nature of a readout scheme of a quantum electrical circuit. The circuit is a superconducting quantum bit measured by microwave reflectometry using a Josephson bifurcation amplifier. We perform a series of two subsequent measurements, record their values and correlation, and quantify the QND character of this readout.

Erbium/ytterbium co-doped double clad fiber amplifier, its applications and effects in fiber optic communication systems

NASA Astrophysics Data System (ADS)

Dua, Puneit

Increased demand for larger bandwidth and longer inter-amplifiers distances translates to higher power budgets for fiber optic communication systems in order to overcome large splitting losses and achieve acceptable signal-to-noise ratios. Due to their unique design ytterbium sensitized erbium doped, double clad fiber amplifiers; offer significant increase in the output powers that can be obtained. In this thesis we investigate, a one-stage, high power erbium and ytterbium co-doped double clad fiber amplifier (DCFA) with output power of 1.4W, designed and built in our lab. Experimental demonstration and numerical simulation techniques have been used to systematically study the applications of such an amplifier and the effects of incorporating it in various fiber optic communication systems. Amplitude modulated subcarrier multiplexed (AM-SCM) CATV distribution experiment has been performed to verify the feasibility of using this amplifier in an analog/digital communication system. The applications of the amplifier as a Fabry-Perot and ring fiber laser with an all-fiber cavity, a broadband supercontinuum source and for generation of high power, short pulses at 5GHz have been experimentally demonstrated. A variety of observable nonlinear effects occur due to the high intensity of the optical powers confined in micron-sized cores of the fibers, this thesis explores in detail some of these effects caused by using the high power Er/Yb double clad fiber amplifier. A fiber optic based analog/digital CATV system experiences composite second order (CSO) distortion due to the interaction between the gain tilt---the variation of gain with wavelength, of the doped fiber amplifier and the wavelength chirp of the directly modulated semiconductor laser. Gain tilt of the Er/Yb co-doped fiber amplifier has been experimentally measured and its contribution to the CSO of the system calculated. Theoretical analysis of a wavelength division multiplexed system with closely spaced channels has been carried out to show that crosstalk can occur due to the four-wave mixing products generated inside the high power Er/Yb DCFA. A model for parametric amplification due to four-wave mixing has been developed and used to analyze its application for short pulse generation and high speed optical time division multiplexing.

A novel piezostack-driven jetting dispenser with corner-filleted flexure hinge and high-frequency performance

NASA Astrophysics Data System (ADS)

Bu, Zhenxiang; Lin, Siying; Huang, Xiang; Li, Anlin; Wu, Dezhi; Zhao, Yang; Luo, Zhiwei; Wang, Lingyun

2018-07-01

This paper presents a new jetting dispenser which is applicable to high-frequency microelectronic packaging. In order to achieve high frequency glue jetting and improve the stability of jetting dispensers, we redesign a novel displacement amplifying mechanism, and a new on–off valve jetting dispenser driven by piezoelectric actuators is developed. Firstly, the core part of this jetting dispenser—the displacement amplifying mechanism with a corner-filleted flexure hinge—is proposed and a comparison with the previous structure is carried out; then the characteristic dimensional parameters of the amplifying mechanism are determined by theoretical calculation and finite element analysis. Secondly, a prototype of the dispenser with the displacement amplifying mechanism is fabricated based on the determined parameters. We use a laser displacement sensor to test the displacement of the needle, and a maximum amplifying displacement output of 367 µm is obtained under an applied 200 V to the piezoelectric actuator, which is consistent with the simulation result and meets the requirement of high displacement output. Thirdly, we build an integrated testing system. Mixed glycerol/ethanol is chosen as the experimental dispensing glue, and the experiment and analysis of a droplet diameter are conducted. A higher jetting frequency of 400 Hz and a smaller droplet diameter of 525 µm are achieved with the glycerol/ethanol mixture, and the characteristics of consistency and temperature influencing the droplet diameter are verified by experiments.

Large area single-mode parity-time-symmetric laser amplifiers.

PubMed

Miri, Mohammad-Ali; LiKamWa, Patrik; Christodoulides, Demetrios N

2012-03-01

By exploiting recent developments associated with parity-time (PT) symmetry in optics, we here propose a new avenue in realizing single-mode large area laser amplifiers. This can be accomplished by utilizing the abrupt symmetry breaking transition that allows the fundamental mode to experience gain while keeping all the higher order modes neutral. Such PT-symmetric structures can be realized by judiciously coupling two multimode waveguides, one exhibiting gain while the other exhibits an equal amount of loss. Pertinent examples are provided for both semiconductor and fiber laser amplifiers. © 2012 Optical Society of America

Differential Amplifier with Current-Mirror Load: Influence of Current Gain, Early Voltage, and Supply Voltage on the DC Output Voltage

ERIC Educational Resources Information Center

Paulik, G. F.; Mayer, R. P.

2012-01-01

A differential amplifier composed of an emitter-coupled pair is useful as an example in lecture presentations and laboratory experiments in electronic circuit analysis courses. However, in an active circuit with zero input load V[subscript id], both laboratory measurements and PSPICE and LTspice simulation results for the output voltage…

Low-noise front-end electronics for detection of intermediate-frequency weak light signals

NASA Astrophysics Data System (ADS)

Lin, Cunbao; Yan, Shuhua; Du, Zhiguang; Wei, Chunhua; Wang, Guochao

2015-02-01

A novel low-noise front-end electronics was proposed for detection of light signals with intensity about 10 μW and frequency above 2.7 MHz. The direct current (DC) power supply, pre-amplifier and main-amplifier were first designed, simulated and then realized. Small-size components were used to make the power supply small, and the pre-amplifier and main-amplifier were the least capacitors to avoid the phase shift of the signals. The performance of the developed front-end electronics was verified in cross-grating diffraction experiments. The results indicated that the output peak-topeak noise of the +/-5 V DC power supply was about 2 mV, and the total output current was 1.25 A. The signal-to-noise ratio (SNR) of the output signal of the pre-amplifier was about 50 dB, and it increased to nearly 60 dB after the mainamplifier, which means this front-end electronics was especially suitable for using in the phase-sensitive and integrated precision measurement systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wong, Melissa; Bolovan-Fritts, Cynthia; Dar, Roy D.

Signal transduction circuits have long been known to differentiate between signals by amplifying inputs to different levels. Here, we describe a novel transcriptional circuitry that dynamically converts greater input levels into faster rates, without increasing the final equilibrium level (i.e. a rate amplifier). We utilize time-lapse microscopy to study human herpesvirus (cytomegalovirus) infection of live cells in real time. Strikingly, our results show that transcriptional activators accelerate viral gene expression in single cells without amplifying the steady-state levels of gene products in these cells. Experiment and modeling show that rate amplification operates by dynamically manipulating the traditional gain-bandwidth feedback relationshipmore » from electrical circuit theory to convert greater input levels into faster rates, and is driven by highly self-cooperative transcriptional feedback encoded by the virus s essential transactivator, IE2. This transcriptional rate-amplifier provides a significant fitness advantage for the virus and for minimal synthetic circuits. In general, rate-amplifiers may provide a mechanism for signal-transduction circuits to respond quickly to external signals without increasing steady-state levels of potentially cytotoxic molecules.« less

Microsecond gain-switched master oscillator power amplifier (1958 nm) with high pulse energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ke Yin; Weiqiang Yang; Bin Zhang

2014-02-28

An all-fibre master oscillator power amplifier (MOPA) emitting high-energy pulses at 1958 nm is presented. The seed laser is a microsecond gain-switched thulium-doped fibre laser (TDFL) pumped with a commercial 1550-nm pulsed fibre laser. The TDFL operates at a repetition rate f in the range of 10 to 100 kHz. The two-stage thulium-doped fibre amplifier is built to scale the energy of the pulses generated by the seed laser. The maximum output pulse energy higher than 0.5 mJ at 10 kHz is achieved which is comparable with the theoretical maximum extractable pulse energy. The slope efficiency of the second stagemore » amplifier with respect to the pump power is 30.4% at f = 10 kHz. The wavelength of the output pulse laser is centred near 1958 nm at a spectral width of 0.25 nm after amplification. Neither nonlinear effects nor significant amplified spontaneous emission (ASE) is observed in the amplification experiments. (lasers)« less

Modeling and Optimization of Class-E Amplifier at Subnominal Condition in a Wireless Power Transfer System for Biomedical Implants.

PubMed

Liu, Hao; Shao, Qi; Fang, Xuelin

2017-02-01

For the class-E amplifier in a wireless power transfer (WPT) system, the design parameters are always determined by the nominal model. However, this model neglects the conduction loss and voltage stress of MOSFET and cannot guarantee the highest efficiency in the WPT system for biomedical implants. To solve this problem, this paper proposes a novel circuit model of the subnominal class-E amplifier. On a WPT platform for capsule endoscope, the proposed model was validated to be effective and the relationship between the amplifier's design parameters and its characteristics was analyzed. At a given duty ratio, the design parameters with the highest efficiency and safe voltage stress are derived and the condition is called 'optimal subnominal condition.' The amplifier's efficiency can reach the highest of 99.3% at the 0.097 duty ratio. Furthermore, at the 0.5 duty ratio, the measured efficiency of the optimal subnominal condition can reach 90.8%, which is 15.2% higher than that of the nominal condition. Then, a WPT experiment with a receiving unit was carried out to validate the feasibility of the optimized amplifier. In general, the design parameters of class-E amplifier in a WPT system for biomedical implants can be determined with the proposed optimization method in this paper.

Analysis of multiple time scales in a transistor amplifier.

PubMed

Armstead, Douglas N; Carroll, Thomas L

2005-03-01

It was shown previously in an experiment that when high frequency signals (on the order of 1 MHz) were injected into this low frequency amplifier, the nonlinearities of the pn junctions caused period doubling, chaos, and very low frequency oscillations (on the order of 1 Hz). In this paper we present theory and simulations to explain the existence of the low frequency oscillations.

Low-frequency switching in a transistor amplifier.

PubMed

Carroll, T L

2003-04-01

It is known from extensive work with the diode resonator that the nonlinear properties of a P-N junction can lead to period doubling, chaos, and other complicated behaviors in a driven circuit. There has been very little work on what happens when more than one P-N junction is present. In this work, the first step towards multiple P-N junction circuits is taken by doing both experiments and simulations with a single-transistor amplifier using a bipolar transistor. Period doubling and chaos are seen when the amplifier is driven with signals between 100 kHz and 1 MHz, and they coincide with a very low frequency switching between different period doubled (or chaotic) wave forms. The switching frequencies are between 5 and 10 Hz. The switching behavior was confirmed in a simplified model of the transistor amplifier.

Design and Experiment of Electrooculogram (EOG) System and Its Application to Control Mobile Robot

NASA Astrophysics Data System (ADS)

Sanjaya, W. S. M.; Anggraeni, D.; Multajam, R.; Subkhi, M. N.; Muttaqien, I.

2017-03-01

In this paper, we design and investigate a biological signal detection of eye movements (Electrooculogram). To detect a signal of Electrooculogram (EOG) used 4 instrument amplifier process; differential instrumentation amplifier, High Pass Filter (HPF) with 3 stage filters, Low Pass Filter (LPF) with 3 stage filters and Level Shifter circuit. The total of amplifying is 1000 times of gain, with frequency range 0.5-30 Hz. IC OP-Amp OP07 was used for all amplifying process. EOG signal will be read as analog input for Arduino microprocessor, and will interfaced with serial communication to PC Monitor using Processing® software. The result of this research show a differences value of eye movements. Differences signal of EOG have been applied to navigation control of the mobile robot. In this research, all communication process using Bluetooth HC-05.

Broadband spectral shaping in regenerative amplifier based on modified polarization-encoded chirped pulse amplification

NASA Astrophysics Data System (ADS)

Wang, Xinliang; Lu, Xiaoming; Liu, Yanqi; Xu, Yi; Wang, Cheng; Li, Shuai; Yu, Linpeng; Liu, Xingyan; Liu, Keyang; Xu, Rongjie; Leng, Yuxin

2018-06-01

We present an intra-cavity spectral shaping method to suppress the spectral narrowing in a Ti:sapphire (Ti:Sa) regenerative amplifier. The spectral shaping is realized by manipulating the stored energies of two Ti:Sa crystals with orthogonal c-axes, changing the length of a quartz plate, and rotating a broadband achromatic half-wave plate. Using this method, in our proof-of-concept experiment, an 84-nm-(FWHM)-broadband amplified pulse with an energy gain larger than 106 is obtained, which supports a 17.8 fs Fourier-transform-limited pulse duration. The pulse is compressed to 18.9 fs.

Theory and Simulation of Gain-Guided Noncollinear Modes in Chirped Quasi-Phase-Matched Optical Parametric Amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charbonneau-Lefort, Mathieu; Afeyan, Bedros; Fejer, Martin

Chirped quasi-phase-matched (QPM) gratings offer essentially constant gain over wide bandwidths, making them promising candidates for short-pulse optical parametric amplifiers. However, experiments have shown that high-gain non-collinear processes exist in spite of the dephasing caused by the non-uniformity of the QPM grating and compete with the desired collinear broadband gain of the amplifier. In this paper, these non-collinear gain-guided modes are investigated numerically and analytically in a model that includes longitudinal non-uniformity of the phase-matching profile, lateral localization of the pump beam and non-collinear propagation of the interacting waves.

Noise in Charge Amplifiers— A gm/ID Approach

NASA Astrophysics Data System (ADS)

Alvarez, Enrique; Avila, Diego; Campillo, Hernan; Dragone, Angelo; Abusleme, Angel

2012-10-01

Charge amplifiers represent the standard solution to amplify signals from capacitive detectors in high energy physics experiments. In a typical front-end, the noise due to the charge amplifier, and particularly from its input transistor, limits the achievable resolution. The classic approach to attenuate noise effects in MOSFET charge amplifiers is to use the maximum power available, to use a minimum-length input device, and to establish the input transistor width in order to achieve the optimal capacitive matching at the input node. These conclusions, reached by analysis based on simple noise models, lead to sub-optimal results. In this work, a new approach on noise analysis for charge amplifiers based on an extension of the gm/ID methodology is presented. This method combines circuit equations and results from SPICE simulations, both valid for all operation regions and including all noise sources. The method, which allows to find the optimal operation point of the charge amplifier input device for maximum resolution, shows that the minimum device length is not necessarily the optimal, that flicker noise is responsible for the non-monotonic noise versus current function, and provides a deeper insight on the noise limits mechanism from an alternative and more design-oriented point of view.

Teaching the Common Emitter Amplifier.

ERIC Educational Resources Information Center

Ellse, Mark D.

1984-01-01

Describes experiments in which a bipolar transistor is used to examine the behavior of a simple circuit. Also addresses problems in teaching the related concepts. (The experiments can be modified to incorporate devices other than bipolar transistors.) (JN)

Laser transmitter for Lidar In-Space Technology Experiment

NASA Technical Reports Server (NTRS)

Chang, John; Cimolino, Marc; Petros, Mulugeta

1991-01-01

The Lidar In-Space Technology Experiment (LITE) Laser Transmitter Module (LTM) flight laser optical architecture has been space qualified by extensive testing at the system, subsystem and component level. The projected system output performance has been verified using an optically and electrically similar breadboard version of the laser. Parasitic lasing was closely examined and completely suppressed after design changes were implemented and tested. Oscillator and amplifier type heads were separately tested to 150 million shots. Critical subassemblies have undergone environmental testing to Shuttle qualification levels. A superior three color anti-reflection coating was developed and tested for use on 14 surfaces after the final amplifier.

Phase noise in RF and microwave amplifiers.

PubMed

Boudot, Rodolphe; Rubiola, Enrico

2012-12-01

Understanding amplifier phase noise is a critical issue in many fields of engineering and physics, such as oscillators, frequency synthesis, telecommunication, radar, and spectroscopy; in the emerging domain of microwave photonics; and in exotic fields, such as radio astronomy, particle accelerators, etc. Focusing on the two main types of base noise in amplifiers, white and flicker, the power spectral density of the random phase φ(t) is Sφ(f) = b(0) + b(-1)/f. White phase noise results from adding white noise to the RF spectrum in the carrier region. For a given RF noise level, b(0) is proportional to the reciprocal of the carrier power P(0). By contrast, flicker results from a near-dc 1/f noise-present in all electronic devices-which modulates the carrier through some parametric effect in the semiconductor. Thus, b(-1) is a parameter of the amplifier, constant in a wide range of P(0). The consequences are the following: Connecting m equal amplifiers in parallel, b(-1) is 1/m times that of one device. Cascading m equal amplifiers, b(-1) is m times that of one amplifier. Recirculating the signal in an amplifier so that the gain increases by a power of m (a factor of m in decibels) as a result of positive feedback (regeneration), we find that b(-1) is m(2) times that of the amplifier alone. The feedforward amplifier exhibits extremely low b(-1) because the carrier is ideally nulled at the input of its internal error amplifier. Starting with an extensive review of the literature, this article introduces a system-oriented model which describes the phase flickering. Several amplifier architectures (cascaded, parallel, etc.) are analyzed systematically, deriving the phase noise from the general model. There follow numerous measurements of amplifiers using different technologies, including some old samples, and in a wide frequency range (HF to microwaves), which validate the theory. In turn, theory and results provide design guidelines and give suggestions for CAD and simulation. To conclude, this article is intended as a tutorial, a review, and a systematic treatise on the subject, supported by extensive experiments.

Imaging non-Gaussian output fields produced by Josephson parametric amplifiers: experiments

NASA Astrophysics Data System (ADS)

Toyli, D. M.; Venkatramani, A. V.; Boutin, S.; Eddins, A.; Didier, N.; Clerk, A. A.; Blais, A.; Siddiqi, I.

2015-03-01

In recent years, squeezed microwave states have become the focus of intense research motivated by applications in continuous-variables quantum computation and precision qubit measurement. Despite numerous demonstrations of vacuum squeezing with superconducting parametric amplifiers such as the Josephson parametric amplifier (JPA), most experiments have also suggested that the squeezed output field becomes non-ideal at the large (> 10dB) signal gains required for low-noise qubit measurement. Here we describe a systematic experimental study of JPA squeezing performance in this regime for varying lumped-element device designs and pumping methods. We reconstruct the JPA output fields through homodyne detection of the field moments and quantify the deviations from an ideal squeezed state using maximal entropy techniques. These methods provide a powerful diagnostic tool to understand how effects such as gain compression impact JPA squeezing. Our results highlight the importance of weak device nonlinearity for generating highly squeezed states. This work is supported by ARO and ONR.

Experimental millimeter-wave personal satellite communications system

NASA Technical Reports Server (NTRS)

Suzuki, Yoshiaki; Kimura, Shigeru; Shimada, Masaaki; Tanaka, Masato; Takahashi, Yasuhiro

1991-01-01

Communications Research Laboratory (CRL) has investigated an advanced millimeter (mm)-wave satellite communications system for personal use. Experiments in mm-wave personal satellite communication are to be conducted for 3 years using Japan's Engineering Test Satellite VI (ETS-VI). This paper describes an experimental mm-wave (43/38 GHz) personal satellite communication system, including an onboard transponder and an earth terminal. The on-board transponder is almost completed, and the ground experiment system is still in the design stage. The transponder employs advanced mm-wave solid state technology. It uses 38 GHz high power solid state amplifiers to accelerate the development of mm-wave solid state devices which are indispensable to personal earth terminals. The transponder consists of a 43 GHz receiver with a built-in low noise amplifier, an IF filter section with very narrow bandwidth to improve the carrier-to-noise power ratio of the weak personal communication signal, and two high power amplifiers using newly developed high power Gallium Arsenide (GaAs) metal-semiconductor field effect transistors (MESFETs).

Demodulation RFI statistics for a 3-stage op amp LED circuit

NASA Astrophysics Data System (ADS)

Whalen, James J.

An experiment has been performed to demonstrate the feasibility of combining several methods of electromagnetic-compatibility analysis. The part of the experiment that demonstrates how RF signals cause interference in an audio-frequency (AF) circuit and how the interference can be suppressed is described. The circuit includes three operational amplifiers (op amps) and a light-emitting diode (LED). A 50 percent amplitude-modulated (AM) radio-frequency-interference (RFI) signal is used, varied over the range from 0.1 to 400 MHz. The AM frequency is 1 kHz. The RFI is injected into the inverting input of the first op amp, and the 1-kHz demodulation response of the amplifier is amplified by the second and third op amps and lights the LED to provide a visual display of the existence of RFI. An RFI suppression capacitor was added to reduce the RFI. The demodulation RFI results are presented as scatter plots for 35 741 op amps. Mean values and standard deviations are also shown.

The Costs of Suppressing Negative Emotions and Amplifying Positive Emotions During Parental Caregiving.

PubMed

Le, Bonnie M; Impett, Emily A

2016-03-01

How do parents feel when they regulate their emotional expressions in ways that are incongruent with their genuine feelings? In an experimental study, parents reported experiencing lower authenticity, emotional well-being, relationship quality, and responsiveness to their children's needs when they recalled caregiving experiences in which they suppressed negative emotions and amplified positive emotions, relative to a control condition. In a 10-day daily experience study, parents tended to use both regulation strategies simultaneously. In addition, assessing their unique effects indicated that positive emotion amplification, but not negative emotion suppression, had an indirect effect on parental outcomes via authenticity, with negative emotion suppression no longer being costly. This indirect effect was dampened when accounting for care difficulty. In both studies, effects were independent of a child's mood. The current results suggest that parents' attempts to suppress negative and amplify positive emotions during child care can detract from their well-being and high-quality parent-child bonds. © 2016 by the Society for Personality and Social Psychology, Inc.

Synergistic effect of mixed neutron and gamma irradiation in bipolar operational amplifier OP07

NASA Astrophysics Data System (ADS)

Yan, Liu; Wei, Chen; Shanchao, Yang; Xiaoming, Jin; Chaohui, He

2016-09-01

This paper presents the synergistic effects in bipolar operational amplifier OP07. The radiation effects are studied by neutron beam, gamma ray, and mixed neutron/gamma ray environments. The characterateristics of the synergistic effects are studied through comparison of different experiment results. The results show that the bipolar operational amplifier OP07 exhibited significant synergistic effects in the mixed neutron and gamma irradiation. The bipolar transistor is identified as the most radiation sensitive unit of the operational amplifier. In this paper, a series of simulations are performed on bipolar transistors in different radiation environments. In the theoretical simulation, the geometric model and calculations based on the Medici toolkit are built to study the radiation effects in bipolar components. The effect of mixed neutron and gamma irradiation is simulated based on the understanding of the underlying mechanisms of radiation effects in bipolar transistors. The simulated results agree well with the experimental data. The results of the experiments and simulation indicate that the radiation effects in the bipolar devices subjected to mixed neutron and gamma environments is not a simple combination of total ionizing dose (TID) effects and displacement damage. The data suggests that the TID effect could enhance the displacement damage. The synergistic effect should not be neglected in complex radiation environments.

The OpenPicoAmp: an open-source planar lipid bilayer amplifier for hands-on learning of neuroscience.

PubMed

Shlyonsky, Vadim; Dupuis, Freddy; Gall, David

2014-01-01

Understanding the electrical biophysical properties of the cell membrane can be difficult for neuroscience students as it relies solely on lectures of theoretical models without practical hands on experiments. To address this issue, we developed an open-source lipid bilayer amplifier, the OpenPicoAmp, which is appropriate for use in introductory courses in biophysics or neurosciences at the undergraduate level, dealing with the electrical properties of the cell membrane. The amplifier is designed using the common lithographic printed circuit board fabrication process and off-the-shelf electronic components. In addition, we propose a specific design for experimental chambers allowing the insertion of a commercially available polytetrafluoroethylene film. We provide a complete documentation allowing to build the amplifier and the experimental chamber. The students hand-out giving step-by step instructions to perform a recording is also included. Our experimental setup can be used in basic experiments in which students monitor the bilayer formation by capacitance measurement and record unitary currents produced by ionic channels like gramicidin A dimers. Used in combination with a low-cost data acquisition board this system provides a complete solution for hands-on lessons, therefore improving the effectiveness in teaching basic neurosciences or biophysics.

The OpenPicoAmp: An Open-Source Planar Lipid Bilayer Amplifier for Hands-On Learning of Neuroscience

PubMed Central

Shlyonsky, Vadim; Dupuis, Freddy; Gall, David

2014-01-01

Understanding the electrical biophysical properties of the cell membrane can be difficult for neuroscience students as it relies solely on lectures of theoretical models without practical hands on experiments. To address this issue, we developed an open-source lipid bilayer amplifier, the OpenPicoAmp, which is appropriate for use in introductory courses in biophysics or neurosciences at the undergraduate level, dealing with the electrical properties of the cell membrane. The amplifier is designed using the common lithographic printed circuit board fabrication process and off-the-shelf electronic components. In addition, we propose a specific design for experimental chambers allowing the insertion of a commercially available polytetrafluoroethylene film. We provide a complete documentation allowing to build the amplifier and the experimental chamber. The students hand-out giving step-by step instructions to perform a recording is also included. Our experimental setup can be used in basic experiments in which students monitor the bilayer formation by capacitance measurement and record unitary currents produced by ionic channels like gramicidin A dimers. Used in combination with a low-cost data acquisition board this system provides a complete solution for hands-on lessons, therefore improving the effectiveness in teaching basic neurosciences or biophysics. PMID:25251830

Jung's equation of the ground of being with the ground of psyche.

PubMed

Dourley, John

2011-09-01

The paper amplifies Jung's psychology of ground associated with the culmination of the alchemical process in the unus mundus. It argues that Jung and Dorn identify the experience of the ground with the experience of divinity as the common originary source of individual and totality. It notes the monistic and pantheistic implications of the experience and goes on to amplify the experience through Eckhart's mediaeval mysticism of ground and Paul Tillich's modern philosophical/theological understanding of ground. It concludes that the Jung/Dorn psychological understanding of ground supersedes monotheistic consciousness. Their vision supports the emergence of a societal myth based on the identification of the ground as the source of all divinities and faith in them. This source currently urges a mythic consciousness that would surpass its past and current concretions and so alleviate the threat that monotheistic consciousness in any domain now poses to human survival. © 2011, The Society of Analytical Psychology.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Braga, D.; Coleman-Smith, P. J.; Davinson, T.

We have designed a read-out ASIC for nuclear decay spectroscopy as part of the AIDA project - the Advanced Implantation Detector Array. AIDA will be installed in experiments at the Facility for Antiproton and Ion Research in GSI, Darmstadt. The AIDA ASIC will measure the signals when unstable nuclei are implanted into the detector, followed by the much smaller signals when the nuclei subsequently decay. Implant energies can be as high as 20 GeV; decay products need to be measured down to 25 keV within just a few microseconds of the initial implants. The ASIC uses two amplifiers per detectormore » channel, one covering the 20 GeV dynamic range, the other selectable over a 20 MeV or 1 GeV range. The amplifiers are linked together by bypass transistors which are normally switched off. The arrival of a large signal causes saturation of the low-energy amplifier and a fluctuation of the input voltage, which activates the link to the high-energy amplifier. The bypass transistors switch on and the input charge is integrated by the high-energy amplifier. The signal is shaped and stored by a peak-hold, then read out on a multiplexed output. Control logic resets the amplifiers and bypass circuit, allowing the low-energy amplifier to measure the subsequent decay signal. We present simulations and test results, demonstrating the AIDA ASIC operation over a wide range of input signals. (authors)« less

Frequency-Offset Cartesian Feedback Based on Polyphase Difference Amplifiers

PubMed Central

Zanchi, Marta G.; Pauly, John M.; Scott, Greig C.

2010-01-01

A modified Cartesian feedback method called “frequency-offset Cartesian feedback” and based on polyphase difference amplifiers is described that significantly reduces the problems associated with quadrature errors and DC-offsets in classic Cartesian feedback power amplifier control systems. In this method, the reference input and feedback signals are down-converted and compared at a low intermediate frequency (IF) instead of at DC. The polyphase difference amplifiers create a complex control bandwidth centered at this low IF, which is typically offset from DC by 200–1500 kHz. Consequently, the loop gain peak does not overlap DC where voltage offsets, drift, and local oscillator leakage create errors. Moreover, quadrature mismatch errors are significantly attenuated in the control bandwidth. Since the polyphase amplifiers selectively amplify the complex signals characterized by a +90° phase relationship representing positive frequency signals, the control system operates somewhat like single sideband (SSB) modulation. However, the approach still allows the same modulation bandwidth control as classic Cartesian feedback. In this paper, the behavior of the polyphase difference amplifier is described through both the results of simulations, based on a theoretical analysis of their architecture, and experiments. We then describe our first printed circuit board prototype of a frequency-offset Cartesian feedback transmitter and its performance in open and closed loop configuration. This approach should be especially useful in magnetic resonance imaging transmit array systems. PMID:20814450

Increasing power and amplified spontaneous emission suppression for weak signal amplification in pulsed fiber amplifier

NASA Astrophysics Data System (ADS)

Luo, Yi; Zhang, Hanwei; Wang, Xiaolin; Su, Rongtao; Ma, Pengfei; Zhou, Pu; Jiang, Zongfu

2017-10-01

In the pulsed fiber amplifiers with repetition frequency of several tens kHz, amplified spontaneous emission (ASE) is easy to build up because of the low repetition frequency and weak pulse signal. The ASE rises the difficulty to amplify the weak pulse signal effectively. We have demonstrated an all-fiber preamplifier stage structure to amplify a 40 kHz, 10 ns bandwidth (FWHM) weak pulse signal (299 μW) with center wavelength of 1062 nm. Compared synchronous pulse pump with continuous wave(CW) pump, the results indicate that synchronous pulse pump shows the better capability of increasing the output power than CW pump. In the condition of the same pump power, the output power of synchronous pulse pump is twice as high as CW pump. In order to suppress ASE, a longer gain fiber is utilized to reabsorb the ASE in which the wavelength is shorter than 1062nm. We amplified weak pulse signal via 0.8 m and 2.1 m gain fiber in synchronous pulse pump experiments respectively, and more ASE in the output spectra are observed in the 0.8 m gain fiber system. Due to the weaker ASE and consequent capability of higher pump power, the 2.1 m gain fiber is capable to achieve higher output power than shorter fiber. The output power of 2.1 m gain fiber case is limited by pump power.

Design and fabrication of an infrared optical pyrometer ASIC as a diagnostic for shock physics experiments

NASA Astrophysics Data System (ADS)

Gordon, Jared

Optical pyrometry is the sensing of thermal radiation emitted from an object using a photoconductive device to convert photons into electrons, and is an important diagnostic tool in shock physics experiments. Data obtained from an optical pyrometer can be used to generate a blackbody curve of the material prior to and after being shocked by a high speed projectile. The sensing element consists of an InGaAs photodiode array, biasing circuitry, and multiple transimpedance amplifiers to boost the weak photocurrent from the noisy dark current into a signal that can eventually be digitized. Once the circuit elements have been defined, more often than not commercial-off-the-shelf (COTS) components are inadequate to satisfy every requirement for the diagnostic, and therefore a custom application specific design has to be considered. This thesis outlines the initial challenges with integrating the photodiode array block with multiple COTS transimpedance amplifiers onto a single chip, and offers a solution to a comparable optical pyrometer that uses the same type of photodiodes in conjunction with a re-designed transimpedance amplifier integrated onto a single chip. The final design includes a thorough analysis of the transimpedance amplifier along with modeling the circuit behavior which entails schematics, simulations, and layout. An alternative circuit is also investigated that incorporates an approach to multiplex the signals from each photodiode onto one data line and not only increases the viable real estate on the chip, but also improves the behavior of the photodiodes as they are subjected to less thermal load. The optical pyrometer application specific integrated circuit (ASIC) for shock physic experiments includes a transimpedance amplifier (TIA) with a 100 kΩ gain operating at bandwidth of 30 MHz, and an input-referred noise RMS current of 50 nA that is capable of driving a 50 Ω load.

Accurate measurement of junctional conductance between electrically coupled cells with dual whole-cell voltage-clamp under conditions of high series resistance.

PubMed

Hartveit, Espen; Veruki, Margaret Lin

2010-03-15

Accurate measurement of the junctional conductance (G(j)) between electrically coupled cells can provide important information about the functional properties of coupling. With the development of tight-seal, whole-cell recording, it became possible to use dual, single-electrode voltage-clamp recording from pairs of small cells to measure G(j). Experiments that require reduced perturbation of the intracellular environment can be performed with high-resistance pipettes or the perforated-patch technique, but an accompanying increase in series resistance (R(s)) compromises voltage-clamp control and reduces the accuracy of G(j) measurements. Here, we present a detailed analysis of methodologies available for accurate determination of steady-state G(j) and related parameters under conditions of high R(s), using continuous or discontinuous single-electrode voltage-clamp (CSEVC or DSEVC) amplifiers to quantify the parameters of different equivalent electrical circuit model cells. Both types of amplifiers can provide accurate measurements of G(j), with errors less than 5% for a wide range of R(s) and G(j) values. However, CSEVC amplifiers need to be combined with R(s)-compensation or mathematical correction for the effects of nonzero R(s) and finite membrane resistance (R(m)). R(s)-compensation is difficult for higher values of R(s) and leads to instability that can damage the recorded cells. Mathematical correction for R(s) and R(m) yields highly accurate results, but depends on accurate estimates of R(s) throughout an experiment. DSEVC amplifiers display very accurate measurements over a larger range of R(s) values than CSEVC amplifiers and have the advantage that knowledge of R(s) is unnecessary, suggesting that they are preferable for long-duration experiments and/or recordings with high R(s). Copyright (c) 2009 Elsevier B.V. All rights reserved.

Designing Ratchets in Ultra-cold Atoms for the Advanced Undergraduate Laboratory

NASA Astrophysics Data System (ADS)

Hachtel, Andrew; Gillette, Matthew; Clements, Ethan; Zhong, Shan; Ducay, Rey; Bali, Samir

2014-05-01

We propose to perform ratchet experiments in cold Rubidium atoms using state-of-the-art home-built tapered amplifier and imaging systems. Our tapered amplifier system amplifies the output from home-built external cavity tunable diode lasers up to a factor 100 and costs less than 5,000, in contrast to commercial tapered amplifier systems, which cost upward of 20,000. We have developed an imaging system with LabVIEW integration, which allows for approximately 2 millisecond exposures and microsecond control of experimental parameters. Our imaging system also costs less than 5,000 in comparison to commercial options, which cost between 40-50,000. Progress toward implementation of a one-dimensional rocking ratchet is described. We gratefully acknowledge funding from the American Chemical Society Petroleum Research Fund and Miami University. We also acknowledge the Miami University Instrumentation Laboratory for their invaluable contributions.

Intensity noise reduction of a high-power nonlinear femtosecond fiber amplifier based on spectral-breathing self-similar parabolic pulse evolution

NASA Astrophysics Data System (ADS)

Wang, Sijia; Liu, Bowen; Song, Youjian; Hu, Minglie

2016-04-01

We report on a simple passive scheme to reduce the intensity noise of high-power nonlinear fiber amplifiers by use of the spectral-breathing parabolic evolution of the pulse amplification with an optimized negative initial chirp. In this way, the influences of amplified spontaneous emission (ASE) on the amplifier intensity noise can be efficiently suppressed, owing to the lower overall pulse chirp, shorter spectral broadening distance, as well as the asymptotic attractive nature of self-similar pulse amplification. Systematic characterizations of the relative intensity noise (RIN) of a free-running nonlinear Yb-doped fiber amplifier are performed over a series of initial pulse parameters. Experiments show that the measured amplifier RIN increases respect to the decreased input pulse energy, due to the increased amount of ASE noise. For pulse amplification with a proper negative initial chirp, the increase of RIN is found to be smaller than with a positive initial chirp, confirming the ASE noise tolerance of the proposed spectral-breathing parabolic amplification scheme. At the maximum output average power of 27W (25-dB amplification gain), the incorporation of an optimum negative initial chirp (-0.84 chirp parameter) leads to a considerable amplifier root-mean-square (rms) RIN reduction of ~20.5% (integrated from 10 Hz to 10 MHz Fourier frequency). The minimum amplifier rms RIN of 0.025% (integrated from 1 kHz to 5 MHz Fourier frequency) is obtained along with the transform-limited compressed pulse duration of 55fs. To our knowledge, the demonstrated intensity noise performance is the lowest RIN level measured from highpower free-running femtosecond fiber amplifiers.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sekatski, Pavel; Sanguinetti, Bruno; Pomarico, Enrico

By amplifying photonic qubits it is possible to produce states that contain enough photons to be seen with the human eye, potentially bringing quantum effects to macroscopic scales [P. Sekatski, N. Brunner, C. Branciard, N. Gisin, and C. Simon, Phys. Rev. Lett. 103, 113601 (2009)]. In this paper we theoretically study quantum states obtained by amplifying one side of an entangled photon pair with different types of optical cloning machines for photonic qubits. We propose a detection scheme that involves lossy threshold detectors (such as the human eye) on the amplified side and conventional photon detectors on the other side.more » We show that correlations obtained with such coarse-grained measurements prove the entanglement of the initial photon pair and do not prove the entanglement of the amplified state. We emphasize the importance of the detection loophole in Bell violation experiments by giving a simple preparation technique for separable states that violate a Bell inequality without closing this loophole. Finally, we analyze the genuine entanglement of the amplified states and its robustness to losses before, during, and after amplification.« less

Cloning entangled photons to scales one can see

NASA Astrophysics Data System (ADS)

Sekatski, Pavel; Sanguinetti, Bruno; Pomarico, Enrico; Gisin, Nicolas; Simon, Christoph

2010-11-01

By amplifying photonic qubits it is possible to produce states that contain enough photons to be seen with the human eye, potentially bringing quantum effects to macroscopic scales [P. Sekatski, N. Brunner, C. Branciard, N. Gisin, and C. Simon, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.103.113601 103, 113601 (2009)]. In this paper we theoretically study quantum states obtained by amplifying one side of an entangled photon pair with different types of optical cloning machines for photonic qubits. We propose a detection scheme that involves lossy threshold detectors (such as the human eye) on the amplified side and conventional photon detectors on the other side. We show that correlations obtained with such coarse-grained measurements prove the entanglement of the initial photon pair and do not prove the entanglement of the amplified state. We emphasize the importance of the detection loophole in Bell violation experiments by giving a simple preparation technique for separable states that violate a Bell inequality without closing this loophole. Finally, we analyze the genuine entanglement of the amplified states and its robustness to losses before, during, and after amplification.

Contrast degradation in a chirped-pulse amplifier due to generation of prepulses by postpulses.

PubMed

Didenko, N V; Konyashchenko, A V; Lutsenko, A P; Tenyakov, S Yu

2008-03-03

Experiment and modeling show that the refractive index nonlinearity can significantly degrade the contrast of a chirped-pulse amplifier seeded with a pulse and a single postpulse. Multiple powerful non-equidistant pre- and postpulses are generated. For a Gaussian pulse and a hat-top beam, an incident postpulse of energy W results in a prepulse of energy 0.58B(2)W, where B is the nonlinear phase (B-integral) of the main pulse. Calculations show that level of satellites due to gain saturation is negligibly small. Experimental results for Ti:Sapphire regenerative and multipass amplifiers and prepulse generation in fused silica agree well with the theory.

Statistics for demodulation RFI in inverting operational amplifier circuits

NASA Astrophysics Data System (ADS)

Sutu, Y.-H.; Whalen, J. J.

An investigation was conducted with the objective to determine statistical variations for RFI demodulation responses in operational amplifier (op amp) circuits. Attention is given to the experimental procedures employed, a three-stage op amp LED experiment, NCAP (Nonlinear Circuit Analysis Program) simulations of demodulation RFI in 741 op amps, and a comparison of RFI in four op amp types. Three major recommendations for future investigations are presented on the basis of the obtained results. One is concerned with the conduction of additional measurements of demodulation RFI in inverting amplifiers, while another suggests the employment of an automatic measurement system. It is also proposed to conduct additional NCAP simulations in which parasitic effects are accounted for more thoroughly.

A 100 J-level nanosecond DPSSL for high energy density experiments

NASA Astrophysics Data System (ADS)

Butcher, Thomas; Mason, Paul; Banerjee, Saumyabrata; Ertel, Klaus; Phillips, P. Jonathan; Smith, Jodie; De Vido, Mariastefania; Chekhlov, Oleg; Divoky, Martin; Pilat, Jan; Priebe, Gerd; Toncian, Toma; Shaikh, Waseem; Hooker, Chris; Lucianetti, Antonio; Hernandez-Gomez, Cristina; Mocek, Tomas; Edwards, Chris; Collier, John

2017-05-01

We present an overview of the cryo-amplifier concept and design utilized in the DiPOLE100 laser system built for use at the HiLASE Center, which has been successfully tested operating at an average power of 1kW. Following this we describe the alterations made to the design in the second generation system being constructed for high energy density (HED) experiments in the HED beamline at the European XFEL. These changes are predominantly geometric in nature, however also include improved mount design and improved control over the temporal shape of the output pulse. Finally, we comment on future plans for development of the DiPOLE laser amplifier architecture.

Photoelectric Effect: Back to Basics.

ERIC Educational Resources Information Center

Powell, R. A.

1978-01-01

Presents a simplified theoretical analysis of the variation of quantum yield with photon energy in the photoelectric experiment. Describes a way to amplify the experiment and make it more instructive to advanced students through the measurement of quantum yield of a photo cell. (GA)

Time Resolved X-Ray Diffraction Study of Acoustoelectrically Amplified Phonons.

NASA Astrophysics Data System (ADS)

Chapman, Leroy Dean

X-rays diffracted by nearly perfect crystals of n-type InSb have been investigated in the presence of intense acoustoelectrically (A.E.) amplified phonons. The fact that these phonons are nearly monochromatic and have a well defined propagation and polarization direction presents an excellent opportunity to investigate the nature of x -ray photon-phonon scattering in a diffracting crystal. The Debye-Waller factor which accounts for the attenuation of diffracted x-ray intensities due to thermal phonons is reflection dependent owing to its sin (theta)/(lamda) dependence. We have performed experiments comparing the (004) and (008) anomalously transmitted intensities as a function of A.E. amplified flux. The attenuation of both reflections due to the amplified phonons was the same in direct contradiction to an expected sin (theta)/(lamda) dependence. Some possible reasons for this failure are discussed. In a Bragg reflection scattering geometry, the intense monochromatic amplified phonons give rise to satellite peaks symmetrically located about the central elastic Brag peak in a rocking profile. We report in this thesis on the first observation of satellites in a thin crystal Laue transmission geometry. We have theoretically simulated the rocking profiles with some success. The A.E. amplification process in InSb is strongly favored for {110} propagation fast transverse (FT) phonons. In earlier experiments it was found that non-{110} FT phonons were also produced during the amplification process. We have developed a time resolved x-ray counting system which, in conjunction with a spatially resolved x-ray beam and a localized, traveling A.E. phonon distribution, allow the time evolution of the amplified distribution to be followed. We report on time resolved measurements for both the symmetric Bragg and Laue geometries from which we can determine when and where non-{110 } FT flux is generated and restrict the possible mechanisms for its generation.

Demonstration of a 140-GHz 1-kW Confocal Gyro-Traveling-Wave Amplifier

PubMed Central

Joye, Colin D.; Shapiro, Michael A.; Sirigiri, Jagadishwar R.; Temkin, Richard J.

2009-01-01

The theory, design, and experimental results of a wideband 140-GHz 1-kW pulsed gyro-traveling-wave amplifier (gyro-TWA) are presented. The gyro-TWA operates in the HE06 mode of an overmoded quasi-optical waveguide using a gyrating electron beam. The electromagnetic theory, interaction theory, design processes, and experimental procedures are described in detail. At 37.7 kV and a 2.7-A beam current, the experiment has produced over 820 W of peak power with a –3-dB bandwidth of 0.8 GHz and a linear gain of 34 dB at 34.7 kV. In addition, the amplifier produced a –3-dB bandwidth of over 1.5 GHz (1.1%) with a peak power of 570 W from a 38.5-kV 2.5-A electron beam. The electron beam is estimated to have a pitch factor of 0.55–0.6, a radius of 1.9 mm, and a calculated perpendicular momentum spread of approximately 9%. The gyro-amplifier was nominally operated at a pulselength of 2 μs but was tested to amplify pulses as short as 4 ns with no noticeable pulse broadening. Internal reflections in the amplifier were identified using these short pulses by time-domain reflectometry. The demonstrated performance of this amplifier shows that it can be applied to dynamic nuclear polarization and electron paramagnetic resonance spectroscopy. PMID:20054451

Millimeter-Wave Gyroklystron Amplifier Experiment Using a Relativistic Electron Beam

DTIC Science & Technology

1990-03-08

Qint to 400 for the TE1 l1 mode, while assisting in suppressing other competing modes [7]. The length of these slots is three times the nominal cavity...frequency by tranverse compression by means of separate clamps. However, cavity deformation affects both the center frequency and the value 5 of Q...amplifier operation was limited by the excitation of parasitic oscillation of the competing TE1 12 mode, as predicted by theory [7]. Despite this

Investigations of SBS and Laser Gain Competition in High-Power Phase Modulated Fiber Amplifiers (Postprint)

DTIC Science & Technology

2014-02-26

through RF filtering . Subsequently, this modulated signal is used in a cutback experiment with a passive fiber . Studies describing enhancement factors...to filter out higher order modes [3]. However, in order to maintain single-mode (diffraction limited) operation, conventional step-index fiber core...Letters 36, 2686-2688 (2011). [3] J. P. Koplaw, D. Kliner, and L. Goldberg, “Single-mode operation of a coiled multimode fiber amplifier,” Optics Letters

An operational amplifier B1404UD1A-1 in the patch-clamp current-to-voltage converter.

PubMed

Korzun, A M; Rozinov, S V; Abashin, G I

1997-01-01

The applicability of the home-made operational amplifier B1404UD1A-1 in a patch-clamp current-to-voltage converter was analyzed. Its parameters (background noise, input bias current, and gain-bandwidth product) were estimated. Schematic solutions and practical recommendations for the use of this amplifier in a current-to-voltage converter were given. Based on the background noise and frequency parameters of the converter, we found that this device can be used for measuring ion channel currents with a high sensitivity and within a broad frequency range (0.055 pA, to 1 kHz; 0.4 pA, to 10 kHz). An example of the converter application in experiments is given.

Dynamic Compression of the Signal in a Charge Sensitive Amplifier: From Concept to Design

NASA Astrophysics Data System (ADS)

Manghisoni, Massimo; Comotti, Daniele; Gaioni, Luigi; Ratti, Lodovico; Re, Valerio

2015-10-01

This work is concerned with the design of a low-noise Charge Sensitive Amplifier featuring a dynamic signal compression based on the non-linear features of an inversion-mode MOS capacitor. These features make the device suitable for applications where a non-linear characteristic of the front-end is required, such as in imaging instrumentation for free electron laser experiments. The aim of the paper is to discuss a methodology for the proper design of the feedback network enabling the dynamic signal compression. Starting from this compression solution, the design of a low-noise Charge Sensitive Amplifier is also discussed. The study has been carried out by referring to a 65 nm CMOS technology.

Noise spectra in balanced optical detectors based on transimpedance amplifiers.

PubMed

Masalov, A V; Kuzhamuratov, A; Lvovsky, A I

2017-11-01

We present a thorough theoretical analysis and experimental study of the shot and electronic noise spectra of a balanced optical detector based on an operational amplifier connected in a transimpedance scheme. We identify and quantify the primary parameters responsible for the limitations of the circuit, in particular, the bandwidth and shot-to-electronic noise clearance. We find that the shot noise spectrum can be made consistent with the second-order Butterworth filter, while the electronic noise grows linearly with the second power of the frequency. Good agreement between the theory and experiment is observed; however, the capacitances of the operational amplifier input and the photodiodes appear significantly higher than those specified in manufacturers' datasheets. This observation is confirmed by independent tests.

Noise spectra in balanced optical detectors based on transimpedance amplifiers

NASA Astrophysics Data System (ADS)

Masalov, A. V.; Kuzhamuratov, A.; Lvovsky, A. I.

2017-11-01

We present a thorough theoretical analysis and experimental study of the shot and electronic noise spectra of a balanced optical detector based on an operational amplifier connected in a transimpedance scheme. We identify and quantify the primary parameters responsible for the limitations of the circuit, in particular, the bandwidth and shot-to-electronic noise clearance. We find that the shot noise spectrum can be made consistent with the second-order Butterworth filter, while the electronic noise grows linearly with the second power of the frequency. Good agreement between the theory and experiment is observed; however, the capacitances of the operational amplifier input and the photodiodes appear significantly higher than those specified in manufacturers' datasheets. This observation is confirmed by independent tests.

Yb3+-doped rod-type amplifiers with local adiabatic tapers for peak power scaling and beam quality improvement

NASA Astrophysics Data System (ADS)

Zhu, Yuan; Eschrich, Tina; Leich, Martin; Grimm, Stephan; Kobelke, Jens; Lorenz, Martin; Bartelt, Hartmut; Jäger, Matthias

2017-10-01

The use of short local tapers in large mode area fiber amplifiers is proposed for peak power scaling while maintaining good beam quality. To avoid modal distortions, the powder-sintering (REPUSIL) method was employed to obtain core materials with excellent refractive index homogeneity. First experiments with Yb3+-doped rod-type amplifiers delivered 2 ns pulses with peak powers of 540 kW and energies of 1.4 mJ for the untapered rod and 230 kW for the tapered rod (limited by facet damage). The beam quality improved from an M 2 value of approximately 10 to 3.5. The investigation of the taper structure indicates room for further improvement.

Integrated double-clad photonic crystal fiber amplifier

NASA Astrophysics Data System (ADS)

Liu, Jun; Gu, Yanran; Chen, Zilun

2017-10-01

This paper studies and fabricates an integrated double-clad photonic crystal fiber amplifier, which overcomes the shortcomings of space application and makes full use of excellent property of double-clad photonic crystal fiber. In the experiment, the (6 + 1) × 1 end-pump coupler with DC-PCF is fabricated. The six pump fibers are fabricated with 105 / 125μm (NA = 0.22) multi-mode fiber. The signal fiber is made of ordinary single-mode fiber SMF-28. Then we spliced the tapered fiber bundle to photonic crystal fiber. At last, we produce double-clad photonic crystal fiber with an end-cap that are able to withstand high average power and protect the system. We have fabricated an integrated Yb-double-clad photonic crystal fiber amplifier.

Thin Disk Ti:Sapphire amplifiers for Joule-class ultrashort pulses with high repetition rate (Conference Presentation)

NASA Astrophysics Data System (ADS)

Nagymihály, Roland S.; Cao, Huabao; Kalashnikov, Mikhail P.; Khodakovskiy, Nikita; Ehrentraut, Lutz; Osvay, Károly; Chvykov, Vladimir V.

2017-05-01

High peak power CPA laser systems can deliver now few petawatt pulses [1]. Reaching the high energies with broad spectral bandwidth necessary for these pulses was possible by the use of large aperture Ti:Sa crystals as final amplifier media. Wide applications for these systems will be possible if the repetition rate could be increased. Therefore, thermal deposition in Ti:Sa amplifiers is a key issue, which has to be solved in case of high average power pumping. The thin disk (TD) laser technology, which is intensively developed nowadays by using new laser materials, is able to overcome thermal distortions and damages of laser crystals [2]. TD technique also has the potential to be used in systems with both high peak and average power. For this, the commonly used laser materials with low absorption and emission cross sections, also low heat conductivity, like Yb:YAG, need to be replaced by a gain medium that supports broad enough emission spectrum and high thermal conductivity to obtain few tens of fs pulses with high repetition rates. Parasitic effects during the amplification process however seriously limit the energy that can be extracted from the gain medium and also they distort the gain profile. Nevertheless, the application of the Extraction During Pumping (EDP) technique can mitigate the depopulation losses in the gain medium with high aspect ratio [3]. We proposed to use Ti:Sa in combination with TD and EDP techniques to reach high energies at high repetition rates, and we presented numerical simulations for different amplifier geometries and parameters of the amplification [4,5]. We present the results of the proof-of-principle experiment, where a EDP-TD Ti:Sa amplifier was tested for the first time. In our experiment, the final cryogenically cooled Ti:Sa amplifier in a 100 TW/10 Hz/28 fs laser system was replaced with the EDP-TD room temperature cooled arrangement. Amplified seed pulse energy of 2.6 J was reached only for 3 passes through TD with 0.5 J of input seed and 5 J of absorbed pump energy. We verified the excellent heat extraction capabilities of our amplifier module. Results of the scaling simulations on the base of this experiment for 100s of TW peak power laser systems operating at up to 100 Hz will be also presented. References 1. Y. Chu et al, Opt. Lett. 40, 5011-5014 (2015). 2. C. R. E. Baer et al, Opt. Exp. 20, 7054-7065 (2012). 3. V. Chvykov et al, Opt. Comm. 285, 2134-2136 (2012). 4. V. Chvykov, R. S. Nagymihaly, H. Cao, M. Kalashnikov, K. Osvay, Opt. Exp. 24, 3721 (2016). 5. V.Chvykov, R. S. Nagymihaly, H. Cao, M. Kalashnikov, K. Osvay, Opt. Lett. 41,13, 3017 (2016).

Analytic and computational modelling of super-radiant pulse compression in plasma and comparisons with experiment

NASA Astrophysics Data System (ADS)

Shvets, Gennady; Kalmykov, Serguei; Dreher, Matthias; Meyer-Ter-Vehn, Juergen

2003-10-01

The strongly non-linear regime of Raman backscattering [1,2] holds the promise of compressing long low-intensity laser beams into ultra-short high intensity pulses. As the short pulse is amplified by the long counter-propagating pump via backscattering the pump off the nonlinear plasma wave, its duration shrinks and intensity grows. The increase of the bandwidth of the amplified pulse only occurs in the nonlinear amplification regime, and is its most telling signature. Recent experiments at MPQ carried out in the strongly nonlinear regime reveal two previously unobserved features: (i) bandwidth expansion, and (ii) breakdown of the initially smooth amplified pulse into several spikes. Using semi-analytic model and particle-in-cell simulations, we explain the multiple pulse formation by the synchrotron motion of plasma electrons in the ponderomotive potential. Self-similar solutions consisting of multiple spikes are derived, and their nonlinear frequency shifts evaluated. The nonlinear focusing of the pulse by the pump is predicted and compared with experimental observations. [1] G. Shvets et. al., Phys. Rev. Lett. 81, 4879 (1998). [2] A. Pukhov, Rep. Progr. Phys. 66, 47 (1998).

Quantum tomography enhanced through parametric amplification

NASA Astrophysics Data System (ADS)

Knyazev, E.; Spasibko, K. Yu; Chekhova, M. V.; Khalili, F. Ya

2018-01-01

Quantum tomography is the standard method of reconstructing the Wigner function of quantum states of light by means of balanced homodyne detection. The reconstruction quality strongly depends on the photodetectors quantum efficiency and other losses in the measurement setup. In this article we analyze in detail a protocol of enhanced quantum tomography, proposed by Leonhardt and Paul [1] which allows one to reduce the degrading effect of detection losses. It is based on phase-sensitive parametric amplification, with the phase of the amplified quadrature being scanned synchronously with the local oscillator phase. Although with sufficiently strong amplification the protocol enables overcoming any detection inefficiency, it was so far not implemented in the experiment, probably due to the losses in the amplifier. Here we discuss a possible proof-of-principle experiment with a traveling-wave parametric amplifier. We show that with the state-of-the-art optical elements, the protocol enables high fidelity tomographic reconstruction of bright non-classical states of light. We consider two examples: bright squeezed vacuum and squeezed single-photon state, with the latter being a non-Gaussian state and both strongly affected by the losses.

Ultra-low output impedance RF power amplifier for parallel excitation.

PubMed

Chu, Xu; Yang, Xing; Liu, Yunfeng; Sabate, Juan; Zhu, Yudong

2009-04-01

Inductive coupling between coil elements of a transmit array is one of the key challenges faced by parallel RF transmission. An ultra-low output impedance RF power amplifier (PA) concept was introduced to address this challenge. In an example implementation, an output-matching network was designed to transform the drain-source impedance of the metallic oxide semiconductor field effect transistor (MOSFET) into a very low value for suppressing interelement coupling effect, and meanwhile, to match the input impedance of the coil to the optimum load of the MOSFET for maximizing the available output power. Two prototype amplifiers with 500-W output rating were developed accordingly, and were further evaluated with a transmit array in phantom experiments. Compared to the conventional 50-Omega sources, the new approach exhibited considerable effectiveness suppressing the effects of interelement coupling. The experiments further indicated that the isolation performance was comparable to that achieved by optimized overlap decoupling. The new approach, benefiting from a distinctive current-source characteristic, also exhibited a superior robustness against load variation. Feasibility of the new approach in high-field MR was demonstrated on a 3T clinical scanner.

Nucleic acid amplification of HIV-1 integrase sequence subtypes CRF01_AE and B for development of HIV anti-integrase drug resistance genotyping assay

NASA Astrophysics Data System (ADS)

Adlar, F. R.; Bela, B.

2017-08-01

To anticipate the potential use of anti-integrase drugs in Indonesia for treatment of HIV-1 infection, the development of a drug resistance genotyping assay for anti-integrase is crucial in identifying the genetic drug resistance profile of Indonesian HIV-1 strains. This experiment aimed to amplify a target region in the integrase gene of Indonesian HIV-1 subtypes CRF01_AE and B that contain genetic mutations known to confer resistance to anti-integrase drug. Eleven archived plasma samples from individuals living with HIV-1 were obtained from the Virology and Cancer Pathobiology Research Center for Health Service (VCPRC FKUI-RSCM) laboratory. One of the plasma samples contained HIV-1 subtype B, and the remaining plasma samples contained subtype CRF01_AE. The target regions for all samples were amplified through RT-PCR, with an annealing temperature of 55 °C, using the primer pair AE_POL 4086F and AE_POL 5232R that were designed by VCPRC FKUI-RSCM. The results of this experiment show that 18.2% (2/11) of the samples were successfully amplified using the one-step RT-PCR. While the primer pair was effective in amplifying the target region in the integrase gene sequence for subtype B (100%; 1/1), it had a low efficacy (10%, 1/10) for subtype CRF01_AE. In conclusion, the primer pair can be used to amplify the target region in Indonesian HIV-1 strain subtypes CRF01_AE and B. However, optimization of the PCR condition and an increased number of samples would help to determine an accurate representation of the efficacy of the primer pair.

Comparison of detection limit in fiber-based conventional, amplified, and gain-clamped cavity ring-down techniques

NASA Astrophysics Data System (ADS)

Sharma, K.; Abdul Khudus, M. I. M.; Alam, S. U.; Bhattacharya, S.; Venkitesh, D.; Brambilla, G.

2018-01-01

Relative performance and detection limit of conventional, amplified, and gain-clamped cavity ring-down techniques (CRDT) in all-fiber configurations are compared experimentally for the first time. Refractive index measurement using evanescent field in tapered fibers is used as a benchmark for the comparison. The systematic optimization of a nested-loop configuration in gain-clamped CRDT is also discussed, which is crucial for achieving a constant gain in a CRDT experiment. It is found that even though conventional CRDT has the lowest standard error in ring-down time (Δτ), the value of ring-down time (τ) is very small, thus leading to poor detection limit. Amplified CRDT provides an improvement in τ, albeit with two orders of magnitude higher Δτ due to amplifier noise. The nested-loop configuration in gain-clamped CRDT helps in reducing Δτ by an order of magnitude as compared to amplified CRDT whilst retaining the improvement in τ. A detection limit of 1 . 03 × 10-4 RIU at refractive index of 1.322 with a 3 mm long and 4.5 μm diameter tapered fiber is demonstrated with the gain-clamped CRDT.

Integrated cladding-pumped multicore few-mode erbium-doped fibre amplifier for space-division-multiplexed communications

NASA Astrophysics Data System (ADS)

Chen, H.; Jin, C.; Huang, B.; Fontaine, N. K.; Ryf, R.; Shang, K.; Grégoire, N.; Morency, S.; Essiambre, R.-J.; Li, G.; Messaddeq, Y.; Larochelle, S.

2016-08-01

Space-division multiplexing (SDM), whereby multiple spatial channels in multimode and multicore optical fibres are used to increase the total transmission capacity per fibre, is being investigated to avert a data capacity crunch and reduce the cost per transmitted bit. With the number of channels employed in SDM transmission experiments continuing to rise, there is a requirement for integrated SDM components that are scalable. Here, we demonstrate a cladding-pumped SDM erbium-doped fibre amplifier (EDFA) that consists of six uncoupled multimode erbium-doped cores. Each core supports three spatial modes, which enables the EDFA to amplify a total of 18 spatial channels (six cores × three modes) simultaneously with a single pump diode and a complexity similar to a single-mode EDFA. The amplifier delivers >20 dBm total output power per core and <7 dB noise figure over the C-band. This cladding-pumped EDFA enables combined space-division and wavelength-division multiplexed transmission over multiple multimode fibre spans.

Research on the liquid coolant applied in the high repetition rate slab amplifier

NASA Astrophysics Data System (ADS)

Wang, Bingyan; Li, Yangshuai; Zhang, Panzheng; Wang, Li; Zhang, Yanli; Feng, Tao; Zhou, Qiong; Liu, Qiang; Li, Haiyuan; Zhang, Xu; Zhou, Shenlei; Ma, Weixin; Zhu, Jian; Zhu, Jianqiang

2018-03-01

High repetition rate slab amplifier (HRRSA) is extraordinarily indispensable for the future fusion power plant, ultra-short laser, laser weapon, and so on. Thermal controlling is the decisive factor for the repetition rate and the output energy of the slab amplifier. For larger clear aperture HRRSA, flash-lamp pumped slab amplifier based on neodymium phosphate glass (Nd:glass) is chosen with the liquid cooling. The liquid coolant circulates across the Nd:glass and takes off the thermal induced in the pumping process. A novel liquid coolant (Series A) whose refractive index is the same with Nd:glass is proposed to alleviate the wavefront distortion induced by thermal. The chemical stability of the liquid coolant under high energy flash-lamp irradiation with 200 shots and under the irradiation of a 1053nm laser with 19 hours and 37 hours are experimented. The results show that the chemical stability of the liquid coolant is stable under irradiation.

[Absorption spectrum of Quasi-continuous laser modulation demodulation method].

PubMed

Shao, Xin; Liu, Fu-Gui; Du, Zhen-Hui; Wang, Wei

2014-05-01

A software phase-locked amplifier demodulation method is proposed in order to demodulate the second harmonic (2f) signal of quasi-continuous laser wavelength modulation spectroscopy (WMS) properly, based on the analysis of its signal characteristics. By judging the effectiveness of the measurement data, filter, phase-sensitive detection, digital filtering and other processing, the method can achieve the sensitive detection of quasi-continuous signal The method was verified by using carbon dioxide detection experiments. The WMS-2f signal obtained by the software phase-locked amplifier and the high-performance phase-locked amplifier (SR844) were compared simultaneously. The results show that the Allan variance of WMS-2f signal demodulated by the software phase-locked amplifier is one order of magnitude smaller than that demodulated by SR844, corresponding two order of magnitude lower of detection limit. And it is able to solve the unlocked problem caused by the small duty cycle of quasi-continuous modulation signal, with a small signal waveform distortion.

Response of geostationary communications satellite solid-state power amplifiers to high-energy electron fluence

NASA Astrophysics Data System (ADS)

Lohmeyer, Whitney; Carlton, Ashley; Wong, Frankie; Bodeau, Michael; Kennedy, Andrew; Cahoy, Kerri

2015-05-01

The key components in communications satellite payloads are the high-power amplifiers that amplify the received signal so that it can be accurately transmitted to the intended end user. In this study, we examine 26 amplifier anomalies and quantify the high-energy electron environment for periods of time prior to the anomalies. Building on the work of Lohmeyer and Cahoy (2013), we find that anomalies occur at a rate higher than just by chance when the >2 MeV electron fluence accumulated over 14 and 21 days is elevated. To try to understand "why," we model the amplifier subsystem to assess whether the dielectric material in the radio frequency (RF) coaxial cables, which are the most exposed part of the system, is liable to experience electrical breakdown due to internal charging. We find that the accumulated electric field over the 14 and 21 days leading up to the anomalies is high enough to cause the dielectric material in the coax to breakdown. We also find that the accumulated voltages reached are high enough to compromise components in the amplifier system, for example, the direct current (DC) blocking capacitor. An electron beam test using a representative coaxial cable terminated in a blocking capacitor showed that discharges could occur with peak voltages and energies sufficient to damage active RF semiconductor devices.

Dual-Phase Lock-In Amplifier Based on FPGA for Low-Frequencies Experiments

PubMed Central

Macias-Bobadilla, Gonzalo; Rodríguez-Reséndiz, Juvenal; Mota-Valtierra, Georgina; Soto-Zarazúa, Genaro; Méndez-Loyola, Maurino; Garduño-Aparicio, Mariano

2016-01-01

Photothermal techniques allow the detection of characteristics of material without invading it. Researchers have developed hardware for some specific Phase and Amplitude detection (Lock-In Function) applications, eliminating space and unnecessary electronic functions, among others. This work shows the development of a Digital Lock-In Amplifier based on a Field Programmable Gate Array (FPGA) for low-frequency applications. This system allows selecting and generating the appropriated frequency depending on the kind of experiment or material studied. The results show good frequency stability in the order of 1.0 × 10−9 Hz, which is considered good linearity and repeatability response for the most common Laboratory Amplitude and Phase Shift detection devices, with a low error and standard deviation. PMID:26999138

Dual-Phase Lock-In Amplifier Based on FPGA for Low-Frequencies Experiments.

PubMed

Macias-Bobadilla, Gonzalo; Rodríguez-Reséndiz, Juvenal; Mota-Valtierra, Georgina; Soto-Zarazúa, Genaro; Méndez-Loyola, Maurino; Garduño-Aparicio, Mariano

2016-03-16

Photothermal techniques allow the detection of characteristics of material without invading it. Researchers have developed hardware for some specific Phase and Amplitude detection (Lock-In Function) applications, eliminating space and unnecessary electronic functions, among others. This work shows the development of a Digital Lock-In Amplifier based on a Field Programmable Gate Array (FPGA) for low-frequency applications. This system allows selecting and generating the appropriated frequency depending on the kind of experiment or material studied. The results show good frequency stability in the order of 1.0 × 10(-9) Hz, which is considered good linearity and repeatability response for the most common Laboratory Amplitude and Phase Shift detection devices, with a low error and standard deviation.

High power pulsed sources based on fiber amplifiers

NASA Astrophysics Data System (ADS)

Canat, Guillaume; Jaouën, Yves; Mollier, Jean-Claude; Bouzinac, Jean-Pierre; Cariou, Jean-Pierre

2017-11-01

Cladding-pumped rare-earth-doped fiber laser technologies are currently among the best sources for high power applications. Theses extremely compact and robust sources appoint them as good candidate for aeronautical and space applications. The double-clad (DC) fiber converts the poor beamquality of high-power large-area pump diodes from the 1st cladding to laser light at another wavelength guided in an active single-mode core. High-power coherent MOPA (Master Oscillator Power Amplifier) sources (several 10W CW or several 100W in pulsed regime) will soon be achieved. Unfortunately it also brings nonlinear effects which quickly impairs output signal distortions. Stimulated Brillouin scattering (SBS) and optical parametric amplification (OPA) have been shown to be strong limitations. Based on amplifier modeling and experiments we discuss the performances of these sources.

Study and Modeling of the Impact of TID on the ATREE Response in LM124 Operational Amplifier

NASA Astrophysics Data System (ADS)

Roig, Fabien; Dusseau, L.; Ribeiro, P.; Auriel, G.; Roche, N. J.-H.; Privat, A.; Vaillé, J.-R.; Boch, J.; Saigné, F.; Marec, R.; Calvel, P.; Bezerra, F.; Ecoffet, R.; Azais, B.

2014-08-01

Shapes of ATREEs (Analog Transient Radiation Effects on Electronics) in a bipolar integrated circuit change with exposure to Total Ionizing Dose (TID) radiation. The impact of TID on ATREEs is investigated in the LM124 operational amplifier (opamp) from three different manufacturers. Significant variations are observed on the ATREE responsesfrom different manufacturers. The ATREEs are produced by pulsed X-ray experiments. ASET laser mappings are performed to highlight the sensitive bipolar transistors, explaining the ATREE phenomena variations from one manufacturer to another one. ATREE modeling results are presented using a previously developed simulation tool. A good agreement is observed between experimental ATREE responses and model outputs whatever the TID level, the prompt dose level, the amplifier configuration and the device manufacturer.

Cryogenic ultra-low power dissipation operational amplifiers with GaAs JFETs

NASA Astrophysics Data System (ADS)

Hibi, Yasunori; Matsuo, Hiroshi; Ikeda, Hirokazu; Fujiwara, Mikio; Kang, Lin; Chen, Jian; Wu, Peiheng

2016-01-01

To realize a multipixel camera for astronomical observation, we developed cryogenic multi-channel readout systems using gallium arsenide junction field-effect transistor (GaAs JFET) integrated circuits (ICs). Based on our experience with these cryogenic ICs, we designed, manufactured, and demonstrated operational amplifiers requiring four power supplies and two voltage sources. The amplifiers operate at 4.2 K with an open-loop gain of 2000. The gain-bandwidth product can expect 400 kHz at a power dissipation of 6 μW. In performance evaluations, the input-referred voltage noise was 4 μVrms/Hz0.5 at 1 Hz and 30 nVrms/Hz0.5 at 10 kHz, respectively. The noise power spectrum density was of type 1/f and extended to 10 kHz.

Optimization of plasma amplifiers

DOE PAGES

Sadler, James D.; Trines, Raoul M. G. M.; Tabak, Max; ...

2017-05-24

Here, plasma amplifiers offer a route to side-step limitations on chirped pulse amplification and generate laser pulses at the power frontier. They compress long pulses by transferring energy to a shorter pulse via the Raman or Brillouin instabilities. We present an extensive kinetic numerical study of the three-dimensional parameter space for the Raman case. Further particle-in-cell simulations find the optimal seed pulse parameters for experimentally relevant constraints. The high-efficiency self-similar behavior is observed only for seeds shorter than the linear Raman growth time. A test case similar to an upcoming experiment at the Laboratory for Laser Energetics is found tomore » maintain good transverse coherence and high-energy efficiency. Effective compression of a 10kJ, nanosecond-long driver pulse is also demonstrated in a 15-cm-long amplifier.« less

Optimization of plasma amplifiers

NASA Astrophysics Data System (ADS)

Sadler, James D.; Trines, Raoul M. Â. G. Â. M.; Tabak, Max; Haberberger, Dan; Froula, Dustin H.; Davies, Andrew S.; Bucht, Sara; Silva, Luís O.; Alves, E. Paulo; Fiúza, Frederico; Ceurvorst, Luke; Ratan, Naren; Kasim, Muhammad F.; Bingham, Robert; Norreys, Peter A.

2017-05-01

Plasma amplifiers offer a route to side-step limitations on chirped pulse amplification and generate laser pulses at the power frontier. They compress long pulses by transferring energy to a shorter pulse via the Raman or Brillouin instabilities. We present an extensive kinetic numerical study of the three-dimensional parameter space for the Raman case. Further particle-in-cell simulations find the optimal seed pulse parameters for experimentally relevant constraints. The high-efficiency self-similar behavior is observed only for seeds shorter than the linear Raman growth time. A test case similar to an upcoming experiment at the Laboratory for Laser Energetics is found to maintain good transverse coherence and high-energy efficiency. Effective compression of a 10 kJ , nanosecond-long driver pulse is also demonstrated in a 15-cm-long amplifier.

Experimenters' reference based upon Skylab experiment management

NASA Technical Reports Server (NTRS)

1974-01-01

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined and amplified, as appropriate. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

Improved amplification results following episodes of failure to amplify at the Amelogenin Locus using PowerPlex® ESI 16 Fast System.

PubMed

Berlyne, Sigal; Oz, Carla; Einot, Naftaly; Avraham, Shlomit; Ram, Tanya; Goldberg, Miri D; Gafny, Ron

2017-07-01

In 2012 the Israel Police DNA Casework laboratory adopted the 16 STR PowerPlex ® ESI kit for routine use. The Promega Company updated this kit and developed the PowerPlex ® ESI 16 Fast System in which all autosomal primer pairs remained identical to the original set, except at the amelogenin site. The master mix was improved and optimized which allowed for direct, faster and more robust amplification. Prior to implementing the PowerPlex ® ESI 16 Fast System in our lab, we conducted a preliminary assay where 213 casework samples were amplified using the new kit. These samples had previously been extracted by one of two extraction kits employed by our lab. (the PrepFiler ExpressTM and PrepFiler BTATM Forensic DNA Extraction Kits). The amplification results from these samples were compared to samples amplified using the original PowerPlex ® ESI 16 kit. Multiple incidents of failure to amplify at the amelogenin locus were noted using the new system with the recommended protocol at a rate of 13% (28 of 213 samples). Experiments were performed to understand whether these amplification failures could be a result of primer binding site mutations, extraction method reagents and/or inhibitors. The conclusions reached following these experiments, in conjunction with consultation with the manufacturer, led to the trial of a modified amplification protocol where the suggested annealing temperature was reduced by 2 degrees. To evaluate the efficiency of this altered protocol, a comparison study was undertaken where 88 additional casework samples were chosen and amplified using both the modified 58°C and the recommended 60°C annealing temperatures. We concluded that the most effective method in our laboratory for achieving a consistent and balanced amplification at the amelogenin locus was to reduce the annealing temperature from the manufacturer's recommended 60°C to 58°C. This modification resulted in a reduction of the failure to amplify at the amelogenin locus from 13% (28/213) to 1.1% (1/88) without any observed changes to the autosomal STR amplification results. Copyright © 2017 Elsevier B.V. All rights reserved.

Flexible Low-power SiGe HBT Amplifier Circuits for Fast Single-shot Spin Readout

NASA Astrophysics Data System (ADS)

England, Troy; Lilly, Michael; Curry, Matthew; Carr, Stephen; Carroll, Malcolm

Fast, low-power quantum state readout is one of many challenges facing quantum information processing. Single electron transistors (SETs) are potentially fast, sensitive detectors for performing spin readout of electrons bound to Si:P donors. From a circuit perspective, however, their output impedance and nonlinear conductance are ill suited to drive the parasitic capacitance of coaxial conductors used in cryogenic environments, necessitating a cryogenic amplification stage. We will introduce two new amplifier topologies that provide excellent gain versus power tradeoffs using silicon-germanium (SiGe) heterojunction bipolar transistors (HBTs). The AC HBT allows in-situ adjustment of power dissipation during an experiment and can provide gain in the millikelvin temperature regime while dissipating less than 500 nW. The AC Current Amplifier maximizes gain at nearly 800 A/A. We will also show results of using these amplifiers with SETs at 4 K. This work was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. DOE Office of Basic Energy Sciences user facility. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a Lockheed-Martin Company, for the U. S. Department of Energy under Contract No. DE-AC04-94AL85000. Flexible Low-power SiGe HBT Amplifier Circuits for Fast Single-shot Spin Readout.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litvinenko,V.; Yakimenko, V.

We propose undertaking a demonstration experiment on suppressing spontaneous undulator radiation from an electron beam at BNL's Accelerator Test Facility (ATF). We describe the method, the proposed layout, and a possible schedule. There are several advantages in strongly suppressing shot noise in the electron beam, and the corresponding spontaneous radiation. The self-amplified spontaneous (SASE) emission originating from shot noise in the electron beam is the main source of noise in high-gain FEL amplifiers. It may negatively affect several HG FEL applications ranging from single- to multi-stage HGHG FELs. SASE saturation also imposes a fundamental hard limit on the gain ofmore » an FEL amplifier in a coherent electron-cooling scheme. A novel active method for suppressing shot noise in relativistic electron beams by many orders-of-magnitude was recently proposed. While theoretically such strong suppression appears feasible, the performance and applicability of this novel method must be evaluated experimentally. Several practical questions about the proposed noise suppressor, such as 3D effects and/or sensitivity to the e-beam parameters also require experimental clarification. To do this, we propose here a proof-of-principle experiment using elements of the VISA FEL at BNL's Accelerator Test Facility.« less

Probing the Mechanisms of an Air Amplifier using a LTQ-FT-ICR-MS and Fluorescence Spectroscopy

PubMed Central

Dixon, R. Brent; Muddiman, David C.; Hawkridge, Adam M.; Fedorov, A. G.

2008-01-01

We report the first quantitative assessment of electrosprayed droplet/ion focusing enabled by the use of a voltage-assisted air amplifier between an electrospray ionization emitter and a hybrid linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (ESI-LTQ-FT-ICR-MS). A solution of fluorescent dye was electrosprayed with a stainless steel mesh screen placed in front of the MS inlet capillary acting as a gas-permeable imaging plate for fluorescence spectroscopy. Without use of the air amplifier no detectable FT-ICR signal was observed, as well as no detectable fluorescence on the screen upon imaging using a fluorescence scanner. When the air amplifier was turned ON while electrospraying the fluorescent dye, FT-ICR mass spectra with high signal to noise ratio were obtained with an average ion injection time of 21 milliseconds for an AGC target value of 5 × 105. Imaging of the screen using a fluorescence scanner produced a distinct spot of cross-sectional area ~33.5 mm2 in front of the MS inlet capillary. These experimental results provide direct evidence of aerodynamic focusing of electrosprayed droplets/ions enabled by an air amplifier, resulting in improved electrospray droplet/ion capture efficiency and reduced ion injection time. A second set of experiments was carried out to explore whether the air amplifier assists in desolvation. By electrospraying a mix of quaternary amines, ratios of increasingly hydrophobic molecules were obtained. Observation of the solvophobic effect associated with electrospray ionization resulted in a higher abundance of the hydrophobic molecule. This bias was eliminated when the air amplifier was turned ON and a response indicative of the respective component concentrations of the molecules in the bulk solution was observed. PMID:17855111

Impact of input FBG reflectivity and forward pump power on RIN transfer in ultralong Raman laser amplifiers.

PubMed

Rizzelli, Giuseppe; Iqbal, Md Asif; Gallazzi, Francesca; Rosa, Paweł; Tan, Mingming; Ania-Castañón, Juan Diego; Krzczanowicz, Lukasz; Corredera, Pedro; Phillips, Ian; Forysiak, Wladek; Harper, Paul

2016-12-12

Relative intensity noise transfer from the pump to the signal in 2nd-order ultra-long Raman laser amplifiers for telecommunications is characterized numerically and experimentally. Our results showcase the need for careful adjustment of the front FBG reflectivity and the relative contribution of forward pump power, and their impact on performance. Finally, our analysis is verified through a 10 × 30 GBaud DP-QPSK transmission experiment, showing a large Q factor penalty associated with the combination of high forward pumping and high reflectivities.

Pre-experiment testing of the Multi Channel Systems 16-channel preamplifier CPA16

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patin, J B; Stoyer, M A; Moody, K J

2003-11-03

The 16-channel preamplifier model CPA16 from Multi Channel Systems was studied. The CPA16 preamplifier/amplifier module is a candidate to be used as the preamplifiers and amplifiers for the focal plane detectors of the Mass Analyzer of Super Heavy Atoms (MASHA). The equipment used to test the CPA16, the results of testing the CPA16 with a pulser, a mixed {sup 229}Th/{sup 148}Gd source and a {sup 252}Cf source, and a summary of the results will be presented.

Fiber optical parametric amplifiers in optical communication systems

PubMed Central

Marhic (†), Michel E; Andrekson, Peter A; Petropoulos, Periklis; Radic, Stojan; Peucheret, Christophe; Jazayerifar, Mahmoud

2015-01-01

The prospects for using fiber optical parametric amplifiers (OPAs) in optical communication systems are reviewed. Phase-insensitive amplifiers (PIAs) and phase-sensitive amplifiers (PSAs) are considered. Low-penalty amplification at/or near 1 Tb/s has been achieved, for both wavelength- and time-division multiplexed formats. High-quality mid-span spectral inversion has been demonstrated at 0.64 Tb/s, avoiding electronic dispersion compensation. All-optical amplitude regeneration of amplitude-modulated signals has been performed, while PSAs have been used to demonstrate phase regeneration of phase-modulated signals. A PSA with 1.1-dB noise figure has been demonstrated, and preliminary wavelength-division multiplexing experiments have been performed with PSAs. 512 Gb/s have been transmitted over 6,000 km by periodic phase conjugation. Simulations indicate that PIAs could reach data rate x reach products in excess of 14,000 Tb/s × km in realistic wavelength-division multiplexed long-haul networks. Technical challenges remaining to be addressed in order for fiber OPAs to become useful for long-haul communication networks are discussed. PMID:25866588

On cuff imbalance and tripolar ENG amplifier configurations.

PubMed

Triantis, Iasonas F; Demosthenous, Andreas; Donaldson, Nick

2005-02-01

Electroneurogram (ENG) recording techniques benefit from the use of tripolar cuffs because they assist in reducing interference from sources outside the cuff. However, in practice the performance of ENG amplifier configurations, such as the quasi-tripole and the true-tripole, has been widely reported to be degraded due to the departure of the tripolar cuff from ideal behavior. This paper establishes the presence of cuff imbalance and investigates its relationship to cuff asymmetry, cuff end-effects and interference source proximity. The paper also presents a comparison of the aforementioned amplifier configurations with a new alternative, termed the adaptive-tripole, developed to automatically compensate for cuff imbalance. The output signal-to-interference ratio of the three amplifier configurations were compared in vivo for two interference signals (stimulus artifact and M-wave) superimposed on compound action potentials. The experiments showed (for the first time) that the two interference signals result in different cuff imbalance values. Nevertheless, even with two distinct cuff imbalances present, the adaptive-tripole performed better than the other two systems in 61.9% of the trials.

A High Sensitivity Preamplifier for Quartz Tuning Forks in QEPAS (Quartz Enhanced PhotoAcoustic Spectroscopy) Applications

PubMed Central

Starecki, Tomasz

2017-01-01

All the preamplifiers dedicated for Quartz Enhanced PhotoAcoustic Spectroscopy (QEPAS) applications that have so far been reported in the literature have been based on operational amplifiers working in transimpedance configurations. Taking into consideration that QEPAS sensors are based on quartz tuning forks, and that quartz has a relatively high voltage constant and relatively low charge constant, it seems that a transimpedance amplifier is not an optimal solution. This paper describes the design of a quartz QEPAS sensor preamplifier, implemented with voltage amplifier configuration. Discussion of an electrical model of the circuit and preliminary measurements are presented. Both theoretical analysis and experiments show that use of the voltage configuration allows for a substantial increase of the output signal in comparison to the transimpedance circuit with the same tuning fork working in identical conditions. Assuming that the sensitivity of the QEPAS technique depends directly on the properties of the preamplifier, use of the voltage amplifier configuration should result in an increase of QEPAS sensitivity by one to two orders of magnitude. PMID:29099765

A High Sensitivity Preamplifier for Quartz Tuning Forks in QEPAS (Quartz Enhanced PhotoAcoustic Spectroscopy) Applications.

PubMed

Starecki, Tomasz; Wieczorek, Piotr Z

2017-11-03

All the preamplifiers dedicated for Quartz Enhanced PhotoAcoustic Spectroscopy (QEPAS) applications that have so far been reported in the literature have been based on operational amplifiers working in transimpedance configurations. Taking into consideration that QEPAS sensors are based on quartz tuning forks, and that quartz has a relatively high voltage constant and relatively low charge constant, it seems that a transimpedance amplifier is not an optimal solution. This paper describes the design of a quartz QEPAS sensor preamplifier, implemented with voltage amplifier configuration. Discussion of an electrical model of the circuit and preliminary measurements are presented. Both theoretical analysis and experiments show that use of the voltage configuration allows for a substantial increase of the output signal in comparison to the transimpedance circuit with the same tuning fork working in identical conditions. Assuming that the sensitivity of the QEPAS technique depends directly on the properties of the preamplifier, use of the voltage amplifier configuration should result in an increase of QEPAS sensitivity by one to two orders of magnitude.

151-km single-end phase-sensitive optical time-domain reflectometer assisted by optical repeater

NASA Astrophysics Data System (ADS)

Song, Muping; Zhu, Weiji; Xia, Qiaolan; Yin, Cong; Lu, Yan; Wu, Ying; Zhuang, Shouwang

2018-02-01

A phase-sensitive optical time-domain reflectometry (ϕOTDR) system that can detect intrusion over 150 km is presented. The ϕOTDR system uses nonbalanced optical repeaters to extend the sensing distance. The repeater consists of two erbium-doped optical fiber amplifiers (EDFAs) and one Raman amplifier (RA). One EDFA power amplifier amplifies the forward-transmitting pulse, and one EDFA preamplifier is used for the backscattering signal, respectively. The RA helps keeping the power along the fiber stable. The optical repeater is installed at the connection of two adjacent fibers to compensate the power decline due to fiber loss. It is easy to install the repeater midway among the fiber links in the system for longer-distance sensing since there is no need of modifying the original sensing system. The theoretical analysis of the repeater is given to describe its effect on the distributed sensing. In experiments, several ϕOTDR traces show a good agreement with theoretical results. Using the optical repeater, 35-Hz vibration at 151 km is successfully measured with signal-to-noise ratio of 8 dB without extra signal processing.

Measurement of SQUID noise levels for SuperCDMS SNOLAB detectors - Final Paper

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Maxwell

SuperCDMS SNOLAB is a second generation direct dark matter search. In the SuperCDMS SNOLAB experiment, detectors are able to pick up from signals from dark matter nuclear recoil interactions which occur inside the bulk of the detectors. These interactions produce both phonon and charge signals. HEMTs read out charge signals whereas TES are used to detect phonon signals which are then read out by SQUID amplifiers. SQUID amplifiers must add negligible noise to the TES intrinsic noise which has been previously measured and is approximately 50pA/√Hz down to 100Hz for ease of signal distinguishability in dark matter nuclear interactions. Themore » intrinsic noise level of the SQUID was tested in the SLAC 300mK fridge and determined to provide adequately low levels of noise with a floor of approximately 3pA/√Hz. Furthermore, a 10x amplifier was tested for addition of extraneous noise. This noise was investigated with and without this amplifier, and it was found that it did not add a significant amount of noise to the intrinsic SQUID noise.« less

Body postures and patterns as amplifiers of physical condition.

PubMed Central

Taylor, P W; Hasson, O; Clark, D L

2000-01-01

The question of why receivers accept a selfish signaller's message as reliable or 'honest' has fuelled ample controversy in discussions of communication. The handicap mechanism is now widely accepted as a potent constraint on cheating. Handicap signals are deemed reliable by their costs: signallers must choose between investing in the signal or in other aspects of fitness. Accordingly, resources allocated to the signal come to reflect the signaller's fitness budget and, on average, cheating is uneconomic. However, that signals may also be deemed reliable by their design, regardless of costs, is not widely appreciated. Here we briefly describe indices and amplifiers, reliable signals that may be essentially cost free. Indices are reliable because they bear a direct association with the signalled quality rather than costs. Amplifiers do not directly provide information about signaller quality, but they facilitate assessment by increasing the apparency of pre-existing cues and signals that are associated with quality. We present results of experiments involving a jumping spider (Plexippus paykulli) to illustrate how amplifiers can facilitate assessment of cues associated with physical condition without invoking the costs required for handicap signalling. PMID:10853735

Modeling and experimental characterization of a new piezoelectric sensor for low-amplitude vibration measurement

NASA Astrophysics Data System (ADS)

Hou, X. Y.; Koh, C. G.; Kuang, K. S. C.; Lee, W. H.

2017-07-01

This paper investigates the capability of a novel piezoelectric sensor for low-frequency and low-amplitude vibration measurement. The proposed design effectively amplifies the input acceleration via two amplifying mechanisms and thus eliminates the use of the external charge amplifier or conditioning amplifier typically employed for measurement system. The sensor is also self-powered, i.e. no external power unit is required. Consequently, wiring and electrical insulation for on-site measurement are considerably simpler. In addition, the design also greatly reduces the interference from rotational motion which often accompanies the translational acceleration to be measured. An analytical model is developed based on a set of piezoelectric constitutive equations and beam theory. Closed-form expression is derived to correlate sensor geometry and material properties with its dynamic performance. Experimental calibration is then carried out to validate the analytical model. After calibration, experiments are carried out to check the feasibility of the new sensor in structural vibration detection. From experimental results, it is concluded that the proposed sensor is suitable for measuring low-frequency and low-amplitude vibrations.

Low-noise cryogenic transmission line

NASA Technical Reports Server (NTRS)

Norris, D.

1987-01-01

New low-noise cryogenic input transmission lines have been developed for the Deep Space Network (DSN) at 1.668 GHz for cryogenically cooled Field Effect Transistors (FET) and High Electron Mobility Transistor (HEMT) amplifiers. These amplifiers exhibit very low noise temperatures of 5 K to 15 K, making the requirements for a low-noise input transmission line critical. Noise contribution to the total amplifier system from the low-noise line is less than 0.5 K for both the 1.668-GHz and 2.25-GHz FET systems. The 1.668-GHz input line was installed in six FET systems which were implemented in the DSN for the Venus Balloon Experiment. The 2.25-GHz input line has been implemented in three FET systems for the DSN 34-m HEF antennas, and the design is currently being considered for use at higher frequencies.

Experimental implementation of a nonlinear beamsplitter based on a phase-sensitive parametric amplifier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Yami; Feng, Jingliang; Cao, Leiming

2016-03-28

Beamsplitters have played an important role in quantum optics experiments. They are often used to split and combine two beams, especially in the construct of an interferometer. In this letter, we experimentally implement a nonlinear beamsplitter using a phase-sensitive parametric amplifier, which is based on four-wave mixing in hot rubidium vapor. Here we show that, despite the different frequencies of the two input beams, the output ports of the nonlinear beamsplitter exhibit interference phenomena. We make measurements of the interference fringe visibility and study how various parameters, such as the intensity gain of the amplifier, the intensity ratio of themore » two input beams, and the one and two photon detunings, affect the behavior of the nonlinear beamsplitter. It may find potential applications in quantum metrology and quantum information processing.« less

Microfluidic Gel Electrophoresis in the Undergraduate Laboratory Applied to Food Analysis

ERIC Educational Resources Information Center

Chao, Tzu-Chiao; Bhattacharya, Sanchari; Ros, Alexandra

2012-01-01

A microfluidics-based laboratory experiment for the analysis of DNA fragments in an analytical undergraduate course is presented. The experiment is set within the context of food species identification via amplified DNA fragments. The students are provided with berry samples from which they extract DNA and perform polymerase chain reaction (PCR)…

Tripolar-cuff deviation from ideal model: assessment by bioelectric field simulations and saline-bath experiments.

PubMed

Triantis, Iasonas F; Demosthenous, Andreas

2008-06-01

Ideally, interference in neural measurements due to signals from nearby muscles can be completely eliminated with the use of tripolar cuffs, in combination with appropriate amplifier configurations, such as the quasi-tripole (QT) and the true-tripole (TT). The operation of these amplifiers, is based on the theoretical property of the nerve cuff to produce a linear relationship of potential versus distance along its length, internally, when external potentials appear between its ends. Thus, in principle, electroneurogram (ENG) recordings from an ideal tripolar cuff would be free from electromyogram (EMG) interference generated by nearby muscles. However, in practice the cuff exhibits non-ideal behaviour leading to "cuff imbalance". The main focus of this paper is to investigate the causes of cuff imbalance, to demonstrate that it should be incorporated as a main parameter in the theoretical ENG-recording cuff electrode model. In addition to cuff asymmetry and tissue growth, the proximity of the interference source to the cuff is shown to result in cuff imbalance. The influence of proximity imbalance on the performance of the QT and TT amplifiers is also considered. Proximity imbalance is studied using bioelectric field simulations and saline-bath experiments. Variation is observed with both distance (40 mm and 70 mm was examined) and orientation (0-180 degrees), with the latter causing a more severe effect especially when the source dipole and the cuff are vertical to each other. The simulations and measurements are in close agreement. Tissue growth imbalance and asymmetry imbalance are also investigated in vitro. Finally, the signal-to-interference ratio (SIR; ENG/EMG) of the QT and TT amplifiers is examined in the presence of cuff imbalance. It is shown that proximity imbalance results in their SIR to peak only at certain cuff orientation values. This important finding offers an insight as to why in practice ENG recordings using these amplifiers have been widely reported to be degraded by EMG interference.

Three-beam coherent combination experiments based on segmented mirrors and measure of phase characteristics of beams passing through Yb-doped fiber amplifier

NASA Astrophysics Data System (ADS)

Yang, Ping; Yang, Ruo fu; Shen, Feng; Ao, Mingwu; Jiang, Wenhan

2009-05-01

Coherent combination is one of the most promising ways to realize high power laser output. A three- laser-beam coherent combination system based on adaptive optics (AO) technique has been set up in our laboratory. In this system, three 1064nm laser beams are placed side-by-side and compressed by two reflective mirrors. An active segmented deformable mirror (DM) is used to compensate the optical path difference (OPD) among three laser beams. The beams are overlapped onto a 2900Hz CCD camera to form an interference pattern while the peak intensity of the interference pattern is taken as the cost function to optimize by a stochastic parallel gradient descent (SPGD) algorithm. SPGD algorithm is realized on a RT-Linux dual-core industrial computer. A series of experiments have been accomplished and experimental results show that both static distorted aberrations in the beams and active distorted aberrations (which are brought in by a hot iron and the frequency is about 5Hz) can be compensated successfully when the gain coefficients and the perturbation amplitude of SPGD are chosed appropriately, thereby three beams can be well combined. For controlling the phase of fiber lasers, the phase characteristics of beams passing through Yb-doped dual-clad fiber amplifier are measured by means of investigating the interference pattern under different output power through experiments. The frequency of phase fluctuation is evaluated through analyzing the fluctuation of power within a 90um aperture of far-field focal spot. Experimental results show that the phase fluctuation frequencies of laser beam transmitted through fiber amplifier are mainly in the range of 100~1500Hz. As a result, to control the phase fluctuation of beams passing through fiber amplifier, the bandwidth of any potential phase control scheme must be greater than 1.5 kilohertz.

Factors that contribute to social media influence within an Internal Medicine Twitter learning community

PubMed Central

Desai, Tejas; Patwardhan, Manish; Coore, Hunter

2014-01-01

Medical societies, faculty, and trainees use Twitter to learn from and educate other social media users. These social media communities bring together individuals with various levels of experience. It is not known if experienced individuals are also the most influential members. We hypothesize that participants with the greatest experience would be the most influential members of a Twitter community. We analyzed the 2013 Association of Program Directors in Internal Medicine Twitter community. We measured the number of tweets authored by each participant and the number of amplified tweets (re-tweets). We developed a multivariate linear regression model to identify any relationship to social media influence, measured by the PageRank. Faculty (from academic institutions) comprised 19% of the 132 participants in the learning community (p < 0.0001). Faculty authored 49% of all 867 tweets (p < 0.0001). Their tweets were the most likely to be amplified (52%, p < 0.01). Faculty had the greatest influence amongst all participants (mean 1.99, p < 0.0001). Being a faculty member had no predictive effect on influence (β = 0.068, p = 0.6). The only factors that predicted influence (higher PageRank) were the number of tweets authored (p < 0.0001) and number of tweets amplified (p < 0.0001) The status of “faculty member” did not confer a greater influence. Any participant who was able to author the greatest number of tweets or have more of his/her tweets amplified could wield a greater influence on the participants, regardless of his/her authority. PMID:25110581

Factors that contribute to social media influence within an Internal Medicine Twitter learning community.

PubMed

Desai, Tejas; Patwardhan, Manish; Coore, Hunter

2014-01-01

Medical societies, faculty, and trainees use Twitter to learn from and educate other social media users. These social media communities bring together individuals with various levels of experience. It is not known if experienced individuals are also the most influential members. We hypothesize that participants with the greatest experience would be the most influential members of a Twitter community. We analyzed the 2013 Association of Program Directors in Internal Medicine Twitter community. We measured the number of tweets authored by each participant and the number of amplified tweets (re-tweets). We developed a multivariate linear regression model to identify any relationship to social media influence, measured by the PageRank. Faculty (from academic institutions) comprised 19% of the 132 participants in the learning community (p < 0.0001). Faculty authored 49% of all 867 tweets (p < 0.0001). Their tweets were the most likely to be amplified (52%, p < 0.01). Faculty had the greatest influence amongst all participants (mean 1.99, p < 0.0001). Being a faculty member had no predictive effect on influence (β = 0.068, p = 0.6). The only factors that predicted influence (higher PageRank) were the number of tweets authored (p < 0.0001) and number of tweets amplified (p < 0.0001) The status of "faculty member" did not confer a greater influence. Any participant who was able to author the greatest number of tweets or have more of his/her tweets amplified could wield a greater influence on the participants, regardless of his/her authority.

Generation of chaotic radiation in a driven traveling wave tube amplifier with time-delayed feedback

NASA Astrophysics Data System (ADS)

Marchewka, Chad; Larsen, Paul; Bhattacharjee, Sudeep; Booske, John; Sengele, Sean; Ryskin, Nikita; Titov, Vladimir

2006-01-01

The application of chaos in communications and radar offers new and interesting possibilities. This article describes investigations on the generation of chaos in a traveling wave tube (TWT) amplifier and the experimental parameters responsible for sustaining stable chaos. Chaos is generated in a TWT amplifier when it is made to operate in a highly nonlinear regime by recirculating a fraction of the TWT output power back to the input in a delayed feedback configuration. A driver wave provides a constant external force to the system making it behave like a forced nonlinear oscillator. The effects of the feedback bandwidth, intensity, and phase are described. The study illuminates the different transitions to chaos and the effect of parameters such as the frequency and intensity of the driver wave. The detuning frequency, i.e., difference frequency between the driver wave and the natural oscillation of the system, has been identified as being an important physical parameter for controlling evolution to chaos. Among the observed routes to chaos, besides the more common period doubling, a new route called loss of frequency locking occurs when the driving frequency is adjacent to a natural oscillation mode. The feedback bandwidth controls the nonlinear dynamics of the system, particularly the number of natural oscillation modes. A computational model has been developed to simulate the experiments and reasonably good agreement is obtained between them. Experiments are described that demonstrate the feasibility of chaotic communications using two TWTs, where one is operated as a driven chaotic oscillator and the other as a time-delayed, open-loop amplifier.

Physics Notes

ERIC Educational Resources Information Center

School Science Review, 1977

1977-01-01

Includes methods for demonstrating Schlieren effect, measuring refractive index, measuring acceleration, presenting concepts of optics, automatically recording weather, constructing apparaturs for sound experiments, using thermistor thermometers, using the 741 operational amplifier in analog computing, measuring inductance, electronically ringing…

The Effects of Aging on Time Reproduction in Delayed Free-Recall

ERIC Educational Resources Information Center

Rakitin, B.C.; Stern, Y.; Malapani, C.

2005-01-01

The experiments presented here demonstrate that normal aging amplifies differences in time production occurring in delayed free-recall testing. Experiment 1 compared the time production ability of two healthy aged groups as well as college-aged participants. During the test session, which followed a 24-h delay and omitted all feedback and examples…

Variation in Septoria musiva and Implications for Disease Resistance Screening

Treesearch

K.T. Ward; M.E. Ostry

2005-01-01

A set of isolates of Septoria musiva differed in aggressiveness in hybrid poplar leaf disk and stem assays and culture growth in vitro. Clone x isolate interactions were observed in one of the stem assay experiments, but not in the leaf disk assay experiments. Random amplified polymorphic DNA (RAPD) analyses were performed using 52 isolates of

Distortion product otoacoustic emission (2f1-f2) amplitude growth in human adults and neonates.

PubMed

Abdala, C

2000-01-01

Distortion product otoacoustic emissions (DPOAEs) are thought to be by-products of an active amplification process in the cochlea and thus serve as a metric for evaluating the integrity of this process. Because the cochlear amplifier functions in a level-dependent fashion, DPOAEs recorded as a function of stimulus level (i.e., a DPOAE growth function) may provide important information about the range and operational characteristics of the cochlear amplifier. The DPOAE growth functions recorded in human adults and neonates may provide information about the maturation of these active cochlear processes. Two experiments were conducted. Experiment I included normal-hearing adults and term-born neonates. The 2f1-f2 DPOAE growth functions were recorded for both age groups at three f2 frequencies. Experiment II was an extension of the first experiment but added a subject group of premature neonates. The results of these studies indicate that DPOAE growth functions most often show amplitude saturation and nonmonotonic growth for all age groups. However, premature neonates show monotonic growth and the absence of amplitude saturation more often than adults. Those premature neonates who do show saturation also show an elevated threshold for amplitude saturation relative to adults. In contrast, term neonates are adultlike for most measures except that they show a larger percentage of nonsaturating growth functions than adults. These results may indicate immaturity in cochlear amplifier function prior to term birth in humans. Outer hair cell function and/or efferent regulation of outer hair cell function are hypothesized sources of this immaturity, although some contribution from the immature middle ear cannot be ruled out.

Research on the ϕ-OTDR fiber sensor sensitive for all of the distance

NASA Astrophysics Data System (ADS)

Kong, Yong; Liu, Yang; Shi, Yi; Ansari, Farhad; Taylor, Todd

2018-01-01

In this paper, a modified construction for the traditional ϕ-OTDR fiber sensor sensitive for all of distance is presented, the related numerical simulation and experiment analysis results show that this construction can reduce the gain imbalance for all of the distance along the fiber caused by the Rayleigh scattering loss of the fiber and the gain imbalance of Raman fiber amplifier in this fiber sensor system. In order to improve further the vibration sensitivity of this system, the possible methods to restrain the influences of modulation instability effect, Stimulated Brillouin effect, reduce the amplified spontaneous emission (ASE) noises of Raman laser (RL) and Erbium3+-doped fiber amplifiers (EDFA), double Rayleigh backscattering noise in this system are discussed, which will offer a great reference value for the science research and engineering application in the field of fiber sensor as we believe.

Monolithic microwave integrated circuits for sensors, radar, and communications systems; Proceedings of the Meeting, Orlando, FL, Apr. 2-4, 1991

NASA Technical Reports Server (NTRS)

Leonard, Regis F. (Editor); Bhasin, Kul B. (Editor)

1991-01-01

Consideration is given to MMICs for airborne phased arrays, monolithic GaAs integrated circuit millimeter wave imaging sensors, accurate design of multiport low-noise MMICs up to 20 GHz, an ultralinear low-noise amplifier technology for space communications, variable-gain MMIC module for space applications, a high-efficiency dual-band power amplifier for radar applications, a high-density circuit approach for low-cost MMIC circuits, coplanar SIMMWIC circuits, recent advances in monolithic phased arrays, and system-level integrated circuit development for phased-array antenna applications. Consideration is also given to performance enhancement in future communications satellites with MMIC technology insertion, application of Ka-band MMIC technology for an Orbiter/ACTS communications experiment, a space-based millimeter wave debris tracking radar, low-noise high-yield octave-band feedback amplifiers to 20 GHz, quasi-optical MESFET VCOs, and a high-dynamic-range mixer using novel balun structure.

Trait reappraisal amplifies subjective defeat, sadness, and negative affect in response to failure versus success in nonclinical and psychosis populations.

PubMed

Johnson, Judith; Gooding, Patricia A; Wood, Alex M; Taylor, Peter J; Tarrier, Nicholas

2011-11-01

Perceptions of defeat have been linked to a range of clinical disorders including psychosis. Perceived defeat sometimes increases in response to failure, but the strength of this association varies between individuals. The present research investigated whether trait reappraisal, a thought-focused coping style, amplified response to stressful events. Two studies (Study 1, n = 120 nonclinical participants; Study 2, n = 77 participants with schizophrenia-spectrum disorders) investigated whether trait reappraisal amplified feelings of defeat following an experience of failure versus success. Frequent reappraisers showed the largest increases in subjective defeat after failure versus success in both studies, with nonclinical participants with greater habitual reappraisal also showing larger increases in sadness and general negative affect. Frequent use of reappraisal may confer vulnerability to subjective defeat in response to stressful life events among nonclinical and clinical populations and could be an area for relapse prevention interventions to target.

PHYSICAL EFFECTS OCCURRING DURING GENERATION AND AMPLIFICATION OF LASER RADIATION: Ultimate values of the gain of solid-state rod amplifiers operating under inversion storage conditions

NASA Astrophysics Data System (ADS)

Bayanov, V. I.; Vinokurov, G. N.; Zhulin, V. I.; Yashin, V. E.

1989-02-01

A numerical calculation is reported of an inversion conservation coefficient of cylindrical rod solid-state amplifiers with the active element diameter from 1.5 to 15 cm operated under continuous pumping conditions. It is shown that the ultimate gain, limited only by superluminescence, exceeds considerably the value usually obtained in experiments. Various methods of eliminating parasitic effects, which limit the gain of real amplifiers, are considered. The degree of influence of these effects on the inversion conservation coefficient is discussed. The results are given of an experimental determination of the gain close to the ultimate value (0.18 cm- 1 for an active element 3 cm in diameter). Calculations are reported of the angular distributions of superluminescence and parasitic modes demonstrating that the latter can be suppressed by spatial filtering.

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

PubMed Central

Chen, Liying; Dharia, Neekesh V.; Ross, Linda; Iniguez, Amanda Balboni; Conway, Amy Saur; Wang, Emily Jue; Veschi, Veronica; Lam, Norris; Gustafson, W. Clay; Nasholm, Nicole; Vazquez, Francisca; Weir, Barbara A.; Ali, Levi D.; Pantel, Sasha; Jiang, Guozhi; Harrington, William F.; Lee, Yenarae; Goodale, Amy; Lubonja, Rakela; Krill-Burger, John M.; Meyers, Robin M.; Root, David E.; Bradner, James E.; Golub, Todd R.; Roberts, Charles W.M.; Hahn, William C.; Weiss, William A.; Thiele, Carol J.

2017-01-01

Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with high-risk disease and poor prognosis. Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-amplified neuroblastoma and found a preferential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EED, and SUZ12. Genetic and pharmacological suppression of EZH2 inhibited neuroblastoma growth in vitro and in vivo. Moreover, compared with neuroblastomas without MYCN amplification, MYCN-amplified neuroblastomas expressed higher levels of EZH2. ChIP analysis showed that MYCN binds at the EZH2 promoter, thereby directly driving expression. Transcriptomic and epigenetic analysis, as well as genetic rescue experiments, revealed that EZH2 represses neuronal differentiation in neuroblastoma in a PRC2-dependent manner. Moreover, MYCN-amplified and high-risk primary tumors from patients with neuroblastoma exhibited strong repression of EZH2-regulated genes. Additionally, overexpression of IGFBP3, a direct EZH2 target, suppressed neuroblastoma growth in vitro and in vivo. We further observed strong synergy between histone deacetylase inhibitors and EZH2 inhibitors. Together, these observations demonstrate that MYCN upregulates EZH2, leading to inactivation of a tumor suppressor program in neuroblastoma, and support testing EZH2 inhibitors in patients with MYCN-amplified neuroblastoma. PMID:29202477

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

PubMed

Chen, Liying; Alexe, Gabriela; Dharia, Neekesh V; Ross, Linda; Iniguez, Amanda Balboni; Conway, Amy Saur; Wang, Emily Jue; Veschi, Veronica; Lam, Norris; Qi, Jun; Gustafson, W Clay; Nasholm, Nicole; Vazquez, Francisca; Weir, Barbara A; Cowley, Glenn S; Ali, Levi D; Pantel, Sasha; Jiang, Guozhi; Harrington, William F; Lee, Yenarae; Goodale, Amy; Lubonja, Rakela; Krill-Burger, John M; Meyers, Robin M; Tsherniak, Aviad; Root, David E; Bradner, James E; Golub, Todd R; Roberts, Charles Wm; Hahn, William C; Weiss, William A; Thiele, Carol J; Stegmaier, Kimberly

2018-01-02

Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with high-risk disease and poor prognosis. Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-amplified neuroblastoma and found a preferential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EED, and SUZ12. Genetic and pharmacological suppression of EZH2 inhibited neuroblastoma growth in vitro and in vivo. Moreover, compared with neuroblastomas without MYCN amplification, MYCN-amplified neuroblastomas expressed higher levels of EZH2. ChIP analysis showed that MYCN binds at the EZH2 promoter, thereby directly driving expression. Transcriptomic and epigenetic analysis, as well as genetic rescue experiments, revealed that EZH2 represses neuronal differentiation in neuroblastoma in a PRC2-dependent manner. Moreover, MYCN-amplified and high-risk primary tumors from patients with neuroblastoma exhibited strong repression of EZH2-regulated genes. Additionally, overexpression of IGFBP3, a direct EZH2 target, suppressed neuroblastoma growth in vitro and in vivo. We further observed strong synergy between histone deacetylase inhibitors and EZH2 inhibitors. Together, these observations demonstrate that MYCN upregulates EZH2, leading to inactivation of a tumor suppressor program in neuroblastoma, and support testing EZH2 inhibitors in patients with MYCN-amplified neuroblastoma.

LD end pumped mode locked and cavity dumped Nd:YAP laser at 1.34 μm

NASA Astrophysics Data System (ADS)

Wang, X.; Wang, S.; Rhee, H.; Eichler, H. J.; Meister, S.

2011-06-01

We report a LD end pumped actively mode locked, passively Q switched and cavity dumped Nd:YAP laser at 1.34 μm. The dumped output pulse energy of 160 μJ is obtained at a repetition rate of 10 Hz. Passing through a LD end pumped, double-passed Nd:YAP amplifier the pulse energy is amplified to 1.44 mJ. The corresponding amplification factor is 9. Stimulated Raman scattering experiment is taken with a 9 mm long PbWO4 Raman crystal. Maximum of 20% Raman conversion is reached.

Production of high energy, uniform focal profiles with the Nike laser

NASA Astrophysics Data System (ADS)

Lehecka, T.; Lehmberg, R. H.; Deniz, A. V.; Gerber, K. A.; Obenschain, S. P.; Pawley, C. J.; Pronko, M. S.; Sullivan, C. A.

1995-02-01

Nike, a KrF laser facility at the Naval Research Laboratory, is designed to produce high intensity, ultra-uniform focal profiles for experiments relating to direct drive inertial confinement fusion. We present measurements of focal profiles through the next-to-last amplifier, a 20 × 20 cm 2 aperture electron beam pumped amplifier capable of producing more than 120 J of output in a 120 ns pulse. Using echelon free induced spatial incoherence beam smoothing this system has produced focal profiles with less than 2% tilt and curvature and less than 2% rms variation from a flat top distribution.

Patterned Roughness for Cross-flow Transition Control at Mach 6

NASA Astrophysics Data System (ADS)

Arndt, Alexander; Matlis, Eric; Semper, Michael; Corke, Thomas

2017-11-01

Experiments are performed to investigate patterned discrete roughness for transition control on a sharp right-circular cone at an angle of attack at Mach 6.0. The approach to transition control is based on exciting less-amplified (subcritical) stationary cross-flow (CF) modes that suppress the growth of the more-amplified (critical) CF modes, and thereby delay transition. The experiments were performed in the Air Force Academy Ludwieg Tube which is a conventional (noisy) design. The cone model is equipped with a motorized 3-D traversing mechanism that mounts on the support sting. The traversing mechanism held a closely-spaced pair of fast-response total pressure Pitot probes. The model utilized a removable tip to exchange between different tip-roughness conditions. Mean flow distortion x-development indicated that the transition Reynolds number increased by 25% with the addition of the subcritical roughness. The energy in traveling disturbances was centered in the band of most amplified traveling CF modes predicted by linear theory. The spatial pattern in the amplitude of the traveling CF modes indicated a nonlinear (sum and difference) interaction between the stationary and traveling CF modes that might explain differences in Retrans between noisy and quiet environments. Air Force Grant FA9550-15-1-0278.

Phase locking of an S-band wide-gap klystron amplifier with high power injection driven by a relativistic backward wave oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bai Xianchen; Zhang Jiande; Yang Jianhua

2012-12-15

Theoretical analyses and preliminary experiments on the phase-locking characteristics of an inductively loaded 2-cavity wide-gap klystron amplifier (WKA) with high power injection driven by a GW-class relativistic backward wave oscillator (RBWO) are presented. Electric power of the amplifier and oscillator is supplied by a single accelerator being capable of producing dual electron beams. The well phase-locking effect of the RBWO-WKA system requires the oscillator have good frequency reproducibility and stability from pulse to pulse. Thus, the main switch of the accelerator is externally triggered to stabilize the diode voltage and then the working frequency. In the experiment, frequency of themore » WKA is linearly locked by the RBWO. With a diode voltage of 530 kV and an input power of {approx}22 MW, an output power of {approx}230 MW with the power gain of {approx}10.2 dB is obtained from the WKA. As the main switch is triggered, the relative phase difference between the RBWO and the WKA is less than {+-}15 Degree-Sign in a single shot, and phase jitter of {+-}11 Degree-Sign is obtained within a series of shots with duration of about 40 ns.« less

Phase locking of an S-band wide-gap klystron amplifier with high power injection driven by a relativistic backward wave oscillator

NASA Astrophysics Data System (ADS)

Bai, Xianchen; Zhang, Jiande; Yang, Jianhua; Jin, Zhenxing

2012-12-01

Theoretical analyses and preliminary experiments on the phase-locking characteristics of an inductively loaded 2-cavity wide-gap klystron amplifier (WKA) with high power injection driven by a GW-class relativistic backward wave oscillator (RBWO) are presented. Electric power of the amplifier and oscillator is supplied by a single accelerator being capable of producing dual electron beams. The well phase-locking effect of the RBWO-WKA system requires the oscillator have good frequency reproducibility and stability from pulse to pulse. Thus, the main switch of the accelerator is externally triggered to stabilize the diode voltage and then the working frequency. In the experiment, frequency of the WKA is linearly locked by the RBWO. With a diode voltage of 530 kV and an input power of ˜22 MW, an output power of ˜230 MW with the power gain of ˜10.2 dB is obtained from the WKA. As the main switch is triggered, the relative phase difference between the RBWO and the WKA is less than ±15° in a single shot, and phase jitter of ±11° is obtained within a series of shots with duration of about 40 ns.

Study of nonlinear interaction between bunched beam and intermediate cavities in a relativistic klystron amplifier

NASA Astrophysics Data System (ADS)

Wu, Y.; Xu, Z.; Li, Z. H.; Tang, C. X.

2012-07-01

In intermediate cavities of a relativistic klystron amplifier (RKA) driven by intense relativistic electron beam, the equivalent circuit model, which is widely adopted to investigate the interaction between bunched beam and the intermediate cavity in a conventional klystron design, is invalid due to the high gap voltage and the nonlinear beam loading in a RKA. According to Maxwell equations and Lorentz equation, the self-consistent equations for beam-wave interaction in the intermediate cavity are introduced to study the nonlinear interaction between bunched beam and the intermediate cavity in a RKA. Based on the equations, the effects of modulation depth and modulation frequency of the beam on the gap voltage amplitude and its phase are obtained. It is shown that the gap voltage is significantly lower than that estimated by the equivalent circuit model when the beam modulation is high. And the bandwidth becomes wider as the beam modulation depth increases. An S-band high gain relativistic klystron amplifier is designed based on the result. And the corresponding experiment is carried out on the linear transformer driver accelerator. The peak output power has achieved 1.2 GW with an efficiency of 28.6% and a gain of 46 dB in the corresponding experiment.

MSFC Skylab experimenter's reference

NASA Technical Reports Server (NTRS)

1974-01-01

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined in the main text and amplified, as appropriate, in appendixes. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

Signal processing and electronic noise in LZ

NASA Astrophysics Data System (ADS)

Khaitan, D.

2016-03-01

The electronics of the LUX-ZEPLIN (LZ) experiment, the 10-tonne dark matter detector to be installed at the Sanford Underground Research Facility (SURF), consists of low-noise dual-gain amplifiers and a 100-MHz, 14-bit data acquisition system for the TPC PMTs. Pre-prototypes of the analog amplifiers and the 32-channel digitizers were tested extensively with simulated pulses that are similar to the prompt scintillation light and the electroluminescence signals expected in LZ. These studies are used to characterize the noise and to measure the linearity of the system. By increasing the amplitude of the test signals, the effect of saturating the amplifier and the digitizers was studied. The RMS ADC noise of the digitizer channels was measured to be 1.19± 0.01 ADCC. When a high-energy channel of the amplifier is connected to the digitizer, the measured noise remained virtually unchanged, while the noise added by a low-energy channel was estimated to be 0.38 ± 0.02 ADCC (46 ± 2 μV). A test facility is under construction to study saturation, mitigate noise and measure the performance of the LZ electronics and data acquisition chain.

High-repetition-rate, narrow-band dye lasers with water as a solvent for dyes

NASA Astrophysics Data System (ADS)

Ray, Alok K.; Sinha, Sucharita; Kundu, Soumitra; Kumar, Sasi; Nair, Sivagiriyal Karunakaran Sreenivasan; Pal, Tamal; Dasgupta, Kamalesh

2002-03-01

The performance of a copper vapor laser-pumped narrow-band dye laser in oscillator-amplifier configuration with water-based binary mixture solvents is described. Although oscillator efficiency in water-surfactant (sodium lauryl sulfate) solvent was comparable with that that employed pure ethanolic solvent, amplifier efficiency was found to be lower. Experiments that were carried out with vertically polarized pump beams and either horizontally or vertically polarized signal beams show that, in case of both the pump and signal having orthogonal polarization (horizontal) and same polarization (vertical), the extraction efficiency for both ethanolic and water-micelle media increased substantially from 15.7% to 18.5% and from 10% to 12.5%, respectively. However, the relative difference remained nearly the same, indicating that a slower orientational diffusion of excited dye molecules in a micellar medium is not responsible for a decrease in amplifier efficiency. Amplifier efficiency comparable with that containing ethanolic dye solutions could be obtained with a binary solvent that comprises a mixture of water and about 30% n-propanol. The performances of two efficient dyes, Rhodamine-6G and Kiton Red S, using water-based solvents were studied.

Characterization of transimpedance amplifier as optical to electrical converter on designing optical instrumentation

NASA Astrophysics Data System (ADS)

Hanto, D.; Ula, R. K.

2017-05-01

Optical to electrical converter is the main components for designing of the optical instrumentations. In addition, this component is also used as signal conditioning. This component usually consists of a photo detector and amplifier. In this paper, characteristics of commercial amplifiers from Thorlabs PDA50B-EC has been observed. The experiment was conducted by diode laser with power of -5 dBm and wavelength 1310 nm; the optical attenuator to vary optical power from 0 to 60 dB, optical to electrical converter from Thorlabs Amplifier PDA50B-EC; multimode optical fiber to guide the laser; and digital voltmeter to measure the output of converter. The results of the characterization indicate that each channel amplification has a non-linear correlation between optical and electrical parameter; optical conversion measurement range of 20-23 dB to full scale; and different measurement coverage area. If this converter will be used as a part component of optical instrumentation so it should be adjusted suitably with the optical power source. Then, because of the correlation equation is not linear so calculation to determine the interpretation also should be considered in addition to the transfer function of the optical sensor.

Turning lemonade into lemons: Dampening appraisals reduce positive affect and increase negative affect during positive activity scheduling.

PubMed

Burr, Leigh-Anne; Javiad, Mahmood; Jell, Grace; Werner-Seidler, Aliza; Dunn, Barnaby D

2017-04-01

The way individuals appraise positive emotions may modulate affective experience during positive activity scheduling. Individuals may either engage in dampening appraisals (e.g., think "this is too good to last") or amplifying appraisals (e.g., think "I deserve this"). A cross-over randomized design was used to examine the consequences of these appraisal styles. Participants (N = 43) rated positive affect (PA) and negative affect (NA) during four daily walks in pleasant locations, whilst following dampening, emotion-focus amplifying (focusing on how good one feels), self-focus amplifying (focusing on positive self qualities), or control instructions. There was no difference between the two amplifying and control conditions, which all increased PA and reduced NA during the walks. However, the dampening condition significantly differed from all other conditions, reducing PA and increasing NA during the walk. Individual differences in anhedonia symptoms did not significantly moderate the pattern of findings. This evidence supports the view that dampening appraisals may be one mechanism driving anhedonia and may account for why positive activity scheduling can sometimes backfire when utilized in the clinic. Copyright © 2017 Elsevier Ltd. All rights reserved.

Circuit Models and Experimental Noise Measurements of Micropipette Amplifiers for Extracellular Neural Recordings from Live Animals

PubMed Central

Chen, Chang Hao; Pun, Sio Hang; Mak, Peng Un; Vai, Mang I; Klug, Achim; Lei, Tim C.

2014-01-01

Glass micropipettes are widely used to record neural activity from single neurons or clusters of neurons extracellularly in live animals. However, to date, there has been no comprehensive study of noise in extracellular recordings with glass micropipettes. The purpose of this work was to assess various noise sources that affect extracellular recordings and to create model systems in which novel micropipette neural amplifier designs can be tested. An equivalent circuit of the glass micropipette and the noise model of this circuit, which accurately describe the various noise sources involved in extracellular recordings, have been developed. Measurement schemes using dead brain tissue as well as extracellular recordings from neurons in the inferior colliculus, an auditory brain nucleus of an anesthetized gerbil, were used to characterize noise performance and amplification efficacy of the proposed micropipette neural amplifier. According to our model, the major noise sources which influence the signal to noise ratio are the intrinsic noise of the neural amplifier and the thermal noise from distributed pipette resistance. These two types of noise were calculated and measured and were shown to be the dominating sources of background noise for in vivo experiments. PMID:25133158

A Direct Reading Thermometer Based on a Silicon Diode.

ERIC Educational Resources Information Center

Kirkup, L.; Tonthat, C.

1998-01-01

Describes a simple circuit based on an inexpensive quad operational amplifier that permits a direct-reading temperature instrument to be constructed using silicon diodes. Encourages the use of this equipment in introductory thermal experiments. (DDR)

Experimental Investigation of Superradiance in a Tapered Free-Electron Laser Amplifier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hidaka, Y.; She, Y.; Murphy, J.B.

2011-03-28

We report experimental studies of the effect of undulator tapering on superradiance in a single-pass high-gain free-electron laser (FEL) amplifier. The experiments were performed at the Source Development Laboratory (SDL) of National Synchrotron Light Source (NSLS). Efficiency was nearly tripled with tapering. Both the temporal and spectral properties of the superradiant FEL along the uniform and tapered undulator were experimentally characterized using frequency-resolved optical gating (FROG) images. Numerical studies predicted pulse broadening and spectral cleaning by undulator tapering Pulse broadening was experimentally verified. However, spectral cleanliness degraded with tapering. We have performed first experiments with a tapered undulator and amore » short seed laser pulse. Pulse broadening with tapering expected from simulations was experimentally confirmed. However, the experimentally obtained spectra degraded with tapering, whereas the simulations predicted improvement. A further numerical study is under way to resolve this issue.« less

Breadboard Amplifier: Building and Using Simple Electrophysiology Equipment.

PubMed

Crisp, Kevin M; Lin, Hunter; Prosper, Issa

2016-01-01

Electrophysiology is a valuable skill for the neuroscientist, but the learning curve for students can be steep. Here we describe a very simple electromyography (EMG) amplifier that can be built from scratch by students with no electronics experience in about 30 minutes, making it ideal for incorporating into a laboratory activity. With few parts and no adjustments except the gain, students can begin physiology experiments quickly while having the satisfaction of having built the equipment themselves. Because the output of the circuit goes to a computer sound card, students can listen to electrophysiological activity as they see it on the computer screen, a feature many of our students greatly appreciated. Various applications are discussed, including dual channel recording, using streaming media platforms with remote lab partners and acquiring data in the field on a smart phone. Our students reported that they enjoyed being able to build a working device and using it to record from their own muscles.

Laboratory Plasma Studies

DTIC Science & Technology

1989-05-23

Intense Rela- tivistic Electron Beams S . A Compact Accelerator Powercd by the Relativistic Klystron Amplifier T. Numerical and Experimental Studies of...Research Laboratory Washingto, IX 2075.6000 NRL Memorandum Report 6419 Megavolt, Multi-Kiloamp K - Band Gyrotron Oscillator Experiment W. M. BLACK,* S . H...Ka- Band Gyrotron Oscillator Experiments with Slotted and Unslotted Cavities S . H. GOLD, MEMBER, IEEE. A. W. FLIFLET, MEMBER, IEEE, W. M. MANHEIMER

DNA sequence divergence among derivatives of Escherichia coli K-12 detected by arbitrary primer PCR (random amplified polymorphic DNA) fingerprinting.

PubMed Central

Brikun, I; Suziedelis, K; Berg, D E

1994-01-01

Derivatives of Escherichia coli K-12 of known ancestry were characterized by random amplified polymorphic DNA (RAPD) fingerprinting to better understand genome evolution in this family of closely related strains. This sensitive method entails PCR amplification with arbitrary primers at low stringency and yields arrays of anonymous DNA fragments that are strain specific. Among 150 fragments scored, eight were polymorphic in that they were produced from some but not all strains. Seven polymorphic bands were chromosomal, and one was from the F-factor plasmid. Five of the six mapped polymorphic chromosomal bands came from just 7% of the genome, a 340-kb segment that includes the terminus of replication. Two of these were from the cryptic Rac prophage, and the inability to amplify them from strains was attributable to deletion (excision) or to rearrangement of Rac. Two other terminus-region segments that resulted in polymorphic bands appeared to have sustained point mutations that affected the ability to amplify them. Control experiments showed that RAPD bands from the 340-kb terminus-region segment and also from two plasmids (P1 and F) were represented in approximate proportion to their size. Optimization experiments showed that the concentration of thermostable polymerase strongly affected the arrays of RAPD products obtained. Comparison of RAPD polymorphisms and positions of strains exhibiting them in the pedigree suggests that many sequence changes occurred in these historic E. coli strains during their storage. We propose that the clustering of such mutations near the terminus reflects errors during completion of chromosome replication, possibly during slow growth in the stab cultures that were often used to store E. coli strains in the early years of bacterial genetics. Images PMID:8132463

Global Effects of Superparameterization on Hydrothermal Land-Atmosphere Coupling on Multiple Timescales

NASA Astrophysics Data System (ADS)

Qin, Hongchen; Pritchard, Michael S.; Kooperman, Gabriel J.; Parishani, Hossein

2018-02-01

Many conventional General Circulation Models (GCMs) in the Global Land-Atmosphere Coupling Experiment (GLACE) tend to produce what is now recognized as overly strong land-atmosphere (L-A) coupling. We investigate the effects of cloud Superparameterization (SP) on L-A coupling on timescales beyond diurnal where it has been recently shown to have a favorable muting effect hydrologically. Using the Community Atmosphere Model v3.5 (CAM3.5) and its Superparameterized counterpart SPCAM3.5, we conducted soil moisture interference experiments following the GLACE and Atmospheric Model Intercomparison Project (AMIP) protocols. The results show that, on weekly-to-subseasonal timescales, SP also mutes hydrologic L-A coupling. This is detectable globally, and happens through the evapotranspiration-precipitation segment. But on seasonal timescales, SP does not exhibit detectable effects on hydrologic L-A coupling. Two robust regional effects of SP on thermal L-A coupling have also been explored. Over the Arabian Peninsula, SP reduces thermal L-A coupling through a straightforward control by mean rainfall reduction. More counterintuitively, over the Southwestern US and Northern Mexico, SP enhances the thermal L-A coupling in a way that is independent of rainfall and soil moisture. This signal is associated with a systematic and previously unrecognized effect of SP that produces an amplified Bowen ratio, and is detectable in multiple SP model versions and experiment designs. In addition to amplifying the present-day Bowen ratio, SP is found to amplify the climate sensitivity of Bowen ratio as well, which likely plays a role in influencing climate change predictions at the L-A interface.

Transport of calcium ions through a bulk membrane by use of a dynamic combinatorial library.

PubMed

Saggiomo, Vittorio; Lüning, Ulrich

2009-07-07

In a bulk membrane transport experiment, a dynamic combinatorial library (DCL) has been used to transport calcium ions; the calcium ions amplify the formation of a macrocyclic carrier which results in transport.

Multi-beam effects on backscatter and its saturation in experiments with conditions relevant to ignition

DOE PAGES

Kirkwood, R. K.; Michel, P.; London, R.; ...

2011-05-26

To optimize the coupling to indirect drive targets in the National Ignition Campaign (NIC) at the National Ignition Facility, a model of stimulated scattering produced by multiple laser beams is used. The model has shown that scatter of the 351 nm beams can be significantly enhanced over single beam predictions in ignition relevant targets by the interaction of the multiple crossing beams with a millimeter scale length, 2.5 keV, 0.02 - 0.05 x critical density, plasma. The model uses a suite of simulation capabilities and its key aspects are benchmarked with experiments at smaller laser facilities. The model has alsomore » influenced the design of the initial targets used for NIC by showing that both the stimulated Brillouin scattering (SBS) and stimulated Raman scattering (SRS) can be reduced by the reduction of the plasma density in the beam intersection volume that is caused by an increase in the diameter of the laser entrance hole (LEH). In this model, a linear wave response leads to a small gain exponent produced by each crossing quad of beams (<~1 per quad) which amplifies the scattering that originates in the target interior where the individual beams are separated and crosses many or all other beams near the LEH as it exits the target. As a result all 23 crossing quads of beams produce a total gain exponent of several or greater for seeds of light with wavelengths in the range that is expected for scattering from the interior (480 to 580 nm for SRS). This means that in the absence of wave saturation, the overall multi-beam scatter will be significantly larger than the expectations for single beams. The potential for non-linear saturation of the Langmuir waves amplifying SRS light is also analyzed with a two dimensional, vectorized, particle in cell code (2D VPIC) that is benchmarked by amplification experiments in a plasma with normalized parameters similar to ignition targets. The physics of cumulative scattering by multiple crossing beams that simultaneously amplify the same SBS light wave is further demonstrated in experiments that benchmark the linear models for the ion waves amplifying SBS. Here, the expectation from this model and its experimental benchmarks is shown to be consistent with observations of stimulated Raman scatter in the first series of energetic experiments with ignition targets, confirming the importance of the multi-beam scattering model for optimizing coupling.« less

Gigawatt peak power generation in a relativistic klystron amplifier driven by 1 kW seed-power

NASA Astrophysics Data System (ADS)

Wu, Y.; Xie, H. Q.; Li, Z. H.; Zhang, Y. J.; Ma, Q. S.

2013-11-01

An S-band high gain relativistic klystron amplifier driven by kW-level RF power is proposed and studied experimentally. In the device, the RF lossy material is introduced to suppress higher mode excitation. An output power of 1.95 GW with a gain of 62.8 dB is obtained in the simulation. Under conditions of an input RF power of 1.38 kW, a microwave pulse with power of 1.9 GW, frequency of 2.86 GHz, and duration of 105 ns is generated in the experiment, and the corresponding gain is 61.4 dB.

High power Yb:CALGO ultrafast regenerative amplifier for industrial application

NASA Astrophysics Data System (ADS)

Caracciolo, E.; Guandalini, A.; Pirzio, F.; Kemnitzer, M.; Kienle, F.; Agnesi, A.; Aus der Au, J.

2017-02-01

We present a high-power, single-crystal based, Yb:CALGO regenerative amplifier. The system delivers more than 50 W output power in continuous-wave regime, with diffraction limited beam quality. In Q-switching regime the spectrum is centered at 1043 nm and is 11 nm wide. In regenerative amplification experiments we achieved 34 W at 500 kHz with 12.7 nm FWHM wide spectra centered at 1044 nm seeding with a broadly tunable, single-prism SESAM mode-locked Yb:CALGO laser providing 9 nm wide spectra at 1049 nm. Pulse duration after compression was 140 fs, with excellent beam quality (M2 < 1.25).

A depolarization and attenuation experiment using the CTS satellite. [meteorological radar

NASA Technical Reports Server (NTRS)

Bostian, C. W.; Holt, S. B., Jr.; Kauffman, S. R.; Manus, E. A.; Marshall, R. E.; Stutzman, W. L.; Wiley, P. H.

1977-01-01

Rain attenuation and depolarization data collected on the communications technology satellite 11.7 GHz downlink, and changes made in equipment following rain leak damage to the parametric amplifier are discussed. A 15 GHz radar system is described.

Analog phase lock between two lasers at LISA power levels

NASA Astrophysics Data System (ADS)

Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten

2009-03-01

This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 μW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

Analog front-end design of the STS/MUCH-XYTER2—full size prototype ASIC for the CBM experiment

NASA Astrophysics Data System (ADS)

Kleczek, Rafal

2017-01-01

The design of the analog front-end of the STS/MUCH-XYTER2 ASIC, a full-size prototype chip for the Silicon Tracking System (STS, based on double-sided silicon strip sensors) and Muon Chamber (MUCH, based on gas sensors) detectors is presented. The ASIC contains 128 charge processing channels, each built of a charge sensitive amplifier, a polarity selection circuit and two pulse shaping amplifiers forming two parallel signal paths. The first path is used for timing measurement with a fast discriminator. The second path allows low-noise amplitude measurement with a 5-bit continuous-time flash ADC. Different operating conditions and constraints posed by two target detectors' applications require front-end electronics flexibility to meet extended system-wise requirements. The presented circuit implements switchable shaper peaking time, gain switching and trimming, input amplifier pulsed reset circuit, fail-safe measures. The power consumption is scalable (for the STS and the MUCH modes), but limited to 10 mW/channel.

Josephson parametric converter saturation and higher order effects

NASA Astrophysics Data System (ADS)

Liu, G.; Chien, T.-C.; Cao, X.; Lanes, O.; Alpern, E.; Pekker, D.; Hatridge, M.

2017-11-01

Microwave parametric amplifiers based on Josephson junctions have become indispensable components of many quantum information experiments. One key limitation which has not been well predicted by theory is the gain saturation behavior which limits the amplifier's ability to process large amplitude signals. The typical explanation for this behavior in phase-preserving amplifiers based on three-wave mixing, such as the Josephson Parametric Converter, is pump depletion, in which the consumption of pump photons to produce amplification results in a reduction in gain. However, in this work, we present experimental data and theoretical calculations showing that the fourth-order Kerr nonlinearities inherent in Josephson junctions are the dominant factor. The Kerr-based theory has the unusual property of causing saturation to both lower and higher gains, depending on bias conditions. This work presents an efficient methodology for optimizing device performance in the presence of Kerr nonlinearities while retaining device tunability and points to the necessity of controlling higher-order Hamiltonian terms to make further improvements in parametric devices.

Sensitivity enhancement of remotely coupled NMR detectors using wirelessly powered parametric amplification.

PubMed

Qian, Chunqi; Murphy-Boesch, Joseph; Dodd, Stephen; Koretsky, Alan

2012-09-01

A completely wireless detection coil with an integrated parametric amplifier has been constructed to provide local amplification and transmission of MR signals. The sample coil is one element of a parametric amplifier using a zero-bias diode that mixes the weak MR signal with a strong pump signal that is obtained from an inductively coupled external loop. The NMR sample coil develops current gain via reduction in the effective coil resistance. Higher gain can be obtained by adjusting the level of the pumping power closer to the oscillation threshold, but the gain is ultimately constrained by the bandwidth requirement of MRI experiments. A feasibility study here shows that on a NaCl/D(2) O phantom, (23) Na signals with 20 dB of gain can be readily obtained with a concomitant bandwidth of 144 kHz. This gain is high enough that the integrated coil with parametric amplifier, which is coupled inductively to external loops, can provide sensitivity approaching that of direct wire connection. Copyright © 2012 Wiley Periodicals, Inc.

Ultrasensitive Electrometry with a Cavity-Embedded Cooper Pair Transistor

NASA Astrophysics Data System (ADS)

Rimberg, A. J.; Li, Juliang

In this experiment a cavity-embedded Cooper-pair transistor (cCPT) is used as a potentially quantum-limited electrometer. The cCPT consists of a Cooper pair transistor placed at the voltage antinode of a 5.7 GHz shorted quarter-wave resonator so that the CPT provides a galvanic connection between the cavity's central conductor and ground plane. The quantum inductance of the CPT, which appears in parallel with the effective inductance of the cavity resonance, can be modulated by application of either a gate voltage to the CPT island or a flux bias to the CPT/cavity loop. Changes in the CPT inductance shift the cavity resonant frequency, and therefore the phase of a microwave signal reflected from the cavity. The reflected wave is amplified by both SLUG and HEMT amplifiers before its phase is measured. The cCPT can also be operated as a Josephson parametric amplifier (JPA). A pump tone at 11.4 GHz sent into the flux bias line has been shown to provide about 10dB gain. The possibility of parametrically amplifying the side bands produced by a charge detection measurement, thereby increasing the overall sensitivity of the cCPT, will also be investigated. Supported by Grants ARO W911NF-13-10377 and NSF DMR 1507400.

On-coil multiple channel transmit system based on class-D amplification and pre-amplification with current amplitude feedback

PubMed Central

Gudino, N.; Heilman, J.A; Riffe, M. J.; Heid, O.; Vester, M.; Griswold, M.A.

2016-01-01

A complete high-efficiency transmit amplifier unit designed to be implemented in on-coil transmit arrays is presented. High power capability, low power dissipation, scalability and cost minimization were some of the requirements imposed to the design. The system is composed of a current mode class-D (CMCD) amplifier output stage and a voltage mode class-D (VMCD) preamplification stage. The amplitude information of the radio frequency pulse was added through a customized step-down DC-DC converter with current amplitude feedback that connects to the CMCD stage. Benchtop measurements and imaging experiments were carried out to analyze system performance. Direct control of B1 was possible and its load sensitivity was reduced to less than 10% variation from unloaded to full loaded condition. When using the amplifiers in an array configuration, isolation above 20 dB was achieved between neighboring coils by the amplifier decoupling method. High output current operation of the transmitter was proved on the benchtop through output power measurements and in a 1.5 T scanner through flip angle quantification. Finally, single and multiple channel excitations with the new hardware were demonstrated by receiving signal with the body coil of the scanner. PMID:22890962

Common mycorrhizal networks amplify competition by preferential mineral nutrient allocation to large host plants.

PubMed

Weremijewicz, Joanna; Sternberg, Leonel da Silveira Lobo O'Reilly; Janos, David P

2016-10-01

Arbuscular mycorrhizal (AM) fungi interconnect plants in common mycorrhizal networks (CMNs) which can amplify competition among neighbors. Amplified competition might result from the fungi supplying mineral nutrients preferentially to hosts that abundantly provide fixed carbon, as suggested by research with organ-cultured roots. We examined whether CMNs supplied (15) N preferentially to large, nonshaded, whole plants. We conducted an intraspecific target-neighbor pot experiment with Andropogon gerardii and several AM fungi in intact, severed or prevented CMNs. Neighbors were supplied (15) N, and half of the target plants were shaded. Intact CMNs increased target dry weight (DW), intensified competition and increased size inequality. Shading decreased target weight, but shaded plants in intact CMNs had mycorrhizal colonization similar to that of sunlit plants. AM fungi in intact CMNs acquired (15) N from the substrate of neighbors and preferentially allocated it to sunlit, large, target plants. Sunlit, intact CMN, target plants acquired as much as 27% of their nitrogen from the vicinity of their neighbors, but shaded targets did not. These results suggest that AM fungi in CMNs preferentially provide mineral nutrients to those conspecific host individuals best able to provide them with fixed carbon or representing the strongest sinks, thereby potentially amplifying asymmetric competition below ground. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

On-coil multiple channel transmit system based on class-D amplification and pre-amplification with current amplitude feedback.

PubMed

Gudino, Natalia; Heilman, Jeremiah A; Riffe, Matthew J; Heid, Oliver; Vester, Markus; Griswold, Mark A

2013-07-01

A complete high-efficiency transmit amplifier unit designed to be implemented in on-coil transmit arrays is presented. High power capability, low power dissipation, scalability, and cost minimization were some of the requirements imposed to the design. The system is composed of a current mode class-D amplifier output stage and a voltage mode class-D preamplification stage. The amplitude information of the radio frequency pulse was added through a customized step-down DC-DC converter with current amplitude feedback that connects to the current mode class-D stage. Benchtop measurements and imaging experiments were carried out to analyze system performance. Direct control of B1 was possible and its load sensitivity was reduced to less than 10% variation from unloaded to full loaded condition. When using the amplifiers in an array configuration, isolation above 20 dB was achieved between neighboring coils by the amplifier decoupling method. High output current operation of the transmitter was proved on the benchtop through output power measurements and in a 1.5T scanner through flip angle quantification. Finally, single and multiple channel excitations with the new hardware were demonstrated by receiving signal with the body coil of the scanner. Copyright © 2012 Wiley Periodicals, Inc.

A practical model of thin disk regenerative amplifier based on analytical expression of ASE lifetime

NASA Astrophysics Data System (ADS)

Zhou, Huang; Chyla, Michal; Nagisetty, Siva Sankar; Chen, Liyuan; Endo, Akira; Smrz, Martin; Mocek, Tomas

2017-12-01

In this paper, a practical model of a thin disk regenerative amplifier has been developed based on an analytical approach, in which Drew A. Copeland [1] had evaluated the loss rate of the upper state laser level due to ASE and derived the analytical expression of the effective life-time of the upper-state laser level by taking the Lorentzian stimulated emission line-shape and total internal reflection into account. By adopting the analytical expression of effective life-time in the rate equations, we have developed a less numerically intensive model for predicting and analyzing the performance of a thin disk regenerative amplifier. Thanks to the model, optimized combination of various parameters can be obtained to avoid saturation, period-doubling bifurcation or first pulse suppression prior to experiments. The effective life-time due to ASE is also analyzed against various parameters. The simulated results fit well with experimental data. By fitting more experimental results with numerical model, we can improve the parameters of the model, such as reflective factor which is used to determine the weight of boundary reflection within the influence of ASE. This practical model will be used to explore the scaling limits imposed by ASE of the thin disk regenerative amplifier being developed in HiLASE Centre.

Integrated Circuits in the Introductory Electronics Laboratory

ERIC Educational Resources Information Center

English, Thomas C.; Lind, David A.

1973-01-01

Discusses the use of an integrated circuit operational amplifier in an introductory electronics laboratory course for undergraduate science majors. The advantages of this approach and the implications for scientific instrumentation are identified. Describes a number of experiments suitable for the undergraduate laboratory. (Author/DF)

Chemical Instrumentation for the Visually Handicapped.

ERIC Educational Resources Information Center

Anderson, James L.

1982-01-01

Describes a simple, relatively inexpensive, and easily implemented approach for introducing visually handicapped students to chemical instrumentation via experiments on operational amplifiers as examples of some of the electronic building blocks of chemical instrumentation. The approach is applicable to other chemical instruments having electrical…

Relativistic Klystron Amplifiers Driven by Modulated Intense Relativistic Electron Beams

DTIC Science & Technology

1990-04-11

electrical parameters of the cavity were calculated using the SUPERFISH computer code. We found: (1) that the gap voltage, V was half as high as the...SUPERFISH computer code and experimenting with various cavities we found the best cavity geometry that fulfilled the above conditions. For this cavity...paths. Experiments along this line are being planned (T. Godlove and F. Mako, private communciation ). A somewhat different concept which also

Battery-powered pulsed high density inductively coupled plasma source for pre-ionization in laboratory astrophysics experiments.

PubMed

Chaplin, Vernon H; Bellan, Paul M

2015-07-01

An electrically floating radiofrequency (RF) pre-ionization plasma source has been developed to enable neutral gas breakdown at lower pressures and to access new experimental regimes in the Caltech laboratory astrophysics experiments. The source uses a customized 13.56 MHz class D RF power amplifier that is powered by AA batteries, allowing it to safely float at 3-6 kV with the electrodes of the high voltage pulsed power experiments. The amplifier, which is capable of 3 kW output power in pulsed (<1 ms) operation, couples electrical energy to the plasma through an antenna external to the 1.1 cm radius discharge tube. By comparing the predictions of a global equilibrium discharge model with the measured scalings of plasma density with RF power input and axial magnetic field strength, we demonstrate that inductive coupling (rather than capacitive coupling or wave damping) is the dominant energy transfer mechanism. Peak ion densities exceeding 5 × 10(19) m(-3) in argon gas at 30 mTorr have been achieved with and without a background field. Installation of the pre-ionization source on a magnetohydrodynamically driven jet experiment reduced the breakdown time and jitter and allowed for the creation of hotter, faster argon plasma jets than was previously possible.

Utilization of a Vircator to drive a High Power Relativistic Klystron Amplifier

NASA Astrophysics Data System (ADS)

Gardelle, J.; Bardy, J.; Cassany, B.; Desanlis, T.; Eyl, P.; Galtié, A.; Modin, P.; Voisin, L.; Balleyguier, P.; Gouard, P.; Donohue, J.

2002-11-01

At CESTA, we have been producing electron beams for some fifteen years by using induction accelerators and pulse diodes. First we had performed Frre-Electron Lasers experiments and we are currently studying the production of High-Power microwaves in the S-band. Among the possible sources we have chosen to perform Relativistic Klystron (RK) experiments with a pulse diode capable of generating a 700kV, 15 kA, 100 ns annular electron beam. In an amplifier configuration, we are testing the idea of using a Vircator as the driver for the first cavity of the klystron. This Vircator uses a simple electrical generator (Marx capacitor bank) which operates in the S-band in the GW class. By reducing the power level to about 100 MW, a 200 ns reliable and reproducible input driver pulse is obtained. First, we present the results of a preliminary experiment for which a coaxial cavity has been built in order to be fed by the Vircator emission at 2.45 GHz. Secondly, we give the experimental results in an oscillator configuration which corresponds to the fisrt step of our RK studies. Comparisons with the results of numerical simulations performed with MAGIC and MAFIA will be given for both experiments.

Excessive response-repetition costs under task switching: how response inhibition amplifies response conflict.

PubMed

Grzyb, Kai Robin; Hübner, Ronald

2013-01-01

The size of response-repetition (RR) costs, which are usually observed on task-switch trials, strongly varies between conditions with univalent and bivalent stimuli. To test whether top-down or bottom-up processes can account for this effect, we assessed in Experiment 1 baselines for univalent and bivalent stimulus conditions (i.e., for stimuli that are associated with either 1 or 2 tasks). Experiment 2 examined whether the proportion of these stimulus types affects RR costs. As the size of RR costs was independent of proportion, a top-down explanation could be excluded. However, there was an increase in RR costs if the current stimulus induced a response conflict. To account for this effect, we proposed an amplification of response conflict account. It assumes that the basic mechanism that leads to RR costs amplifies response conflict, which, in turn, increases RR costs. Experiment 3 confirmed this bottom-up explanation by showing that the increase in RR costs varies with previous-trial congruency, which is known to affect RR costs. Experiment 4 showed that the increase can also be found with univalent stimuli that induce response conflict. Altogether, the results are in line with a response inhibition account of RR costs. Implications for alternative accounts are also discussed. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Reading Mammal Diversity from Flies: The Persistence Period of Amplifiable Mammal mtDNA in Blowfly Guts (Chrysomya megacephala) and a New DNA Mini-Barcode Target.

PubMed

Lee, Ping-Shin; Sing, Kong-Wah; Wilson, John-James

2015-01-01

Most tropical mammal species are threatened or data-deficient. Data collection is impeded by the traditional monitoring approaches which can be laborious, expensive and struggle to detect cryptic diversity. Monitoring approaches using mammal DNA derived from invertebrates are emerging as cost- and time-effective alternatives. As a step towards development of blowfly-derived DNA as an effective method for mammal monitoring in the biodiversity hotspot of Peninsular Malaysia, our objectives were (i) to determine the persistence period of amplifiable mammal mtDNA in blowfly guts through a laboratory feeding experiment (ii) to design and test primers that can selectively amplify mammal COI DNA mini-barcodes in the presence of high concentrations of blowfly DNA. The persistence period of amplifiable mammal mtDNA in blowfly guts was 24 h to 96 h post-feeding indicating the need for collecting flies within 24 h of capture to detect mammal mtDNA of sufficient quantity and quality. We designed a new primer combination for a COI DNA mini-barcode that did not amplify blowfly DNA and showed 89% amplification success for a dataset of mammals from Peninsular Malaysia. The short (205 bp) DNA mini-barcode could distinguish most mammal species (including separating dark taxa) and is of suitable length for high-throughput sequencing. Our new DNA mini-barcode target and a standardized trapping protocol with retrieval of blowflies every 24 h could point the way forward in the development of blowfly-derived DNA as an effective method for mammal monitoring.

An instrumentation amplifier based readout circuit for a dual element microbolometer infrared detector

NASA Astrophysics Data System (ADS)

de Waal, D. J.; Schoeman, J.

2014-06-01

The infrared band is widely used in many applications to solve problems stretching over very diverse fields, ranging from medical applications like inflammation detection to military, security and safety applications employing thermal imaging in low light conditions. At the heart of these optoelectrical systems lies a sensor used to detect incident infrared radiation, and in the case of this work our focus is on uncooled microbolometers as thermal detectors. Microbolometer based thermal detectors are limited in sensitivity by various parameters, including the detector layout and design, operating temperature, air pressure and biasing that causes self heating. Traditional microbolometers use the entire membrane surface for a single detector material. This work presents the design of a readout circuit amplifier where a dual detector element microbolometer is used, rather than the traditional single element. The concept to be investigated is based on the principle that both elements will be stimulated with a similar incoming IR signal and experience the same resistive change, thus creating a common mode signal. However, such a common mode signal will be rejected by a differential amplifier, thus one element is placed within a negative resistance converter to create a differential mode signal that is twice the magnitude of the comparable single mode signal of traditional detector designs. An instrumentation amplifier is used for the final stage of the readout amplifier circuit, as it allows for very high common mode rejection with proper trimming of the Wheatstone bridge to compensate for manufacturing tolerance. It was found that by implementing the above, improved sensitivity can be achieved.

Reading Mammal Diversity from Flies: The Persistence Period of Amplifiable Mammal mtDNA in Blowfly Guts (Chrysomya megacephala) and a New DNA Mini-Barcode Target

PubMed Central

Lee, Ping-Shin; Sing, Kong-Wah; Wilson, John-James

2015-01-01

Most tropical mammal species are threatened or data-deficient. Data collection is impeded by the traditional monitoring approaches which can be laborious, expensive and struggle to detect cryptic diversity. Monitoring approaches using mammal DNA derived from invertebrates are emerging as cost- and time-effective alternatives. As a step towards development of blowfly-derived DNA as an effective method for mammal monitoring in the biodiversity hotspot of Peninsular Malaysia, our objectives were (i) to determine the persistence period of amplifiable mammal mtDNA in blowfly guts through a laboratory feeding experiment (ii) to design and test primers that can selectively amplify mammal COI DNA mini-barcodes in the presence of high concentrations of blowfly DNA. The persistence period of amplifiable mammal mtDNA in blowfly guts was 24 h to 96 h post-feeding indicating the need for collecting flies within 24 h of capture to detect mammal mtDNA of sufficient quantity and quality. We designed a new primer combination for a COI DNA mini-barcode that did not amplify blowfly DNA and showed 89% amplification success for a dataset of mammals from Peninsular Malaysia. The short (205 bp) DNA mini-barcode could distinguish most mammal species (including separating dark taxa) and is of suitable length for high-throughput sequencing. Our new DNA mini-barcode target and a standardized trapping protocol with retrieval of blowflies every 24 h could point the way forward in the development of blowfly-derived DNA as an effective method for mammal monitoring. PMID:25898278

Effect of sustained elevated temperature prior to amplification on template copy number estimation using digital polymerase chain reaction.

PubMed

Bhat, Somanath; McLaughlin, Jacob L H; Emslie, Kerry R

2011-02-21

Digital polymerase chain reaction (dPCR) has the potential to enable accurate quantification of target DNA copy number provided that all target DNA molecules are successfully amplified. Following duplex dPCR analysis from a linear DNA target sequence that contains single copies of two independent template sequences, we have observed that amplification of both templates in a single partition does not always occur. To investigate this finding, we heated the target DNA solution to 95 °C for increasing time intervals and then immediately chilled on ice prior to preparing the dPCR mix. We observed an exponential decline in estimated copy number (R(2)≥ 0.98) of the two template sequences when amplified from either a linearized plasmid or a 388 base pair (bp) amplicon containing the same two template sequences. The distribution of amplifiable templates and the final concentration (copies per µL) were both affected by heat treatment of the samples at 95 °C from 0 s to 30 min. The proportion of target sequences from which only one of the two templates was amplified in a single partition (either 1507 or hmg only) increased over time, while the proportion of target sequences where both templates were amplified (1507 and hmg) in each individual partition declined rapidly from 94% to 52% (plasmid) and 88% to 31% (388 bp amplicon) suggesting an increase in number of targets from which both templates no longer amplify. A 10 min incubation at 95 °C reduced the initial amplifiable template concentration of the plasmid and the 388 bp amplicon by 59% and 91%, respectively. To determine if a similar decrease in amplifiable target occurs during the default pre-activation step of typical PCR amplification protocol, we used mastermixes with a 20 s or 10 min hot-start. The choice of mastermix and consequent pre-activation time did not affect the estimated plasmid concentration. Therefore, we conclude that prolonged exposure of this DNA template to elevated temperatures could lead to significant bias in dPCR measurements. However, care must be taken when designing PCR and non-PCR based experiments by reducing exposure of the DNA template to sustained elevated temperatures in order to improve accuracy in copy number estimation and concentration determination.

Electronic amplifiers: A compilation

NASA Technical Reports Server (NTRS)

1971-01-01

Several types of amplifiers and amplifier systems are considered. These include preamplifiers, high power amplifiers, buffer and isolation amplifiers, amplifier circuits, and general purpose amplifiers.

Investment Dynamics with Natural Expectations.

PubMed

Fuster, Andreas; Hebert, Benjamin; Laibson, David

2010-01-01

We study an investment model in which agents have the wrong beliefs about the dynamic properties of fundamentals. Specifically, we assume that agents underestimate the rate of mean reversion. The model exhibits the following six properties: (i) Beliefs are excessively optimistic in good times and excessively pessimistic in bad times. (ii) Asset prices are too volatile. (iii) Excess returns are negatively autocorrelated. (iv) High levels of corporate profits predict negative future excess returns. (v) Real economic activity is excessively volatile; the economy experiences amplified investment cycles. (vi) Corporate profits are positively autocorrelated in the short run and negatively autocorrelated in the medium run. The paper provides an illustrative model of animal spirits, amplified business cycles, and excess volatility.

Investment Dynamics with Natural Expectations*

PubMed Central

Fuster, Andreas; Hebert, Benjamin; Laibson, David

2012-01-01

We study an investment model in which agents have the wrong beliefs about the dynamic properties of fundamentals. Specifically, we assume that agents underestimate the rate of mean reversion. The model exhibits the following six properties: (i) Beliefs are excessively optimistic in good times and excessively pessimistic in bad times. (ii) Asset prices are too volatile. (iii) Excess returns are negatively autocorrelated. (iv) High levels of corporate profits predict negative future excess returns. (v) Real economic activity is excessively volatile; the economy experiences amplified investment cycles. (vi) Corporate profits are positively autocorrelated in the short run and negatively autocorrelated in the medium run. The paper provides an illustrative model of animal spirits, amplified business cycles, and excess volatility. PMID:23243469

Characterization of feedback resistors for cryogenic applications

NASA Technical Reports Server (NTRS)

Lakew, B.; Moseley, S. H.; Silverberg, R. F.

1989-01-01

Results are presented on the testing of feedback resistors selected for use in the transimpedance amplifiers (TIAs) in the Diffuse Infrared Background Experiment (DIRBE) to be flown on the NASA's Cosmic Background Explorer satellite planned for a launch in 1989. The resistors without encapsulation were found to be reliable as cryogenic circuit elements. Their resistance is sufficiently high (so that their Johnson noise does not dominate amplifier noise at the signal frequency), and they are sufficiently linear; no correction need to be made for signals up to 1.5 V, the 100,000 signal-to-noise level for the DIRBE, which covers most of the signals expected to be seen on the sky.

Method and apparatus for linear low-frequency feedback in monolithic low-noise charge amplifiers

DOEpatents

DeGeronimo, Gianluigi

2006-02-14

A charge amplifier includes an amplifier, feedback circuit, and cancellation circuit. The feedback circuit includes a capacitor, inverter, and current mirror. The capacitor is coupled across the signal amplifier, the inverter is coupled to the output of the signal amplifier, and the current mirror is coupled to the input of the signal amplifier. The cancellation circuit is coupled to the output of the signal amplifier. A method of charge amplification includes providing a signal amplifier; coupling a first capacitor across the signal amplifier; coupling an inverter to the output of the signal amplifier; coupling a current mirror to the input of the signal amplifier; and coupling a cancellation circuit to the output of the signal amplifier. A front-end system for use with radiation sensors includes a charge amplifier and a current amplifier, shaping amplifier, baseline stabilizer, discriminator, peak detector, timing detector, and logic circuit coupled to the charge amplifier.

A fungal mock community control for amplicon sequencing experiments

USDA-ARS?s Scientific Manuscript database

Microbial ecology has been profoundly advanced by the ability to profile complex microbial communities by sequencing of marker genes amplified from environmental samples. However, inclusion of appropriate controls is vital to revealing the limitations and biases of this technique. “Mock community” s...

A fungal mock community control for amplicon sequencing experiments

USDA-ARS?s Scientific Manuscript database

The field of microbial ecology has been profoundly advanced by the ability to profile the composition of complex microbial communities by means of high throughput amplicon sequencing of marker genes amplified directly from environmental genomic DNA extracts. However, it has become increasingly clear...

The Meaning-Enhancing Properties of Psychedelics and Their Mediator Role in Psychedelic Therapy, Spirituality, and Creativity.

PubMed

Hartogsohn, Ido

2018-01-01

Past research has demonstrated to the ability of psychedelics to enhance suggestibility, and pointed to their ability to amplify perception of meaning. This paper examines the existing evidence for the meaning-enhancing properties of psychedelics, and argues that the tendency of these agents to enhance the perception of significance offers valuable clues to explaining their reported ability to stimulate a variety of therapeutic processes, enhance creativity, and instigate mystical-type experiences. Building upon previous research, which suggested the potential role of psychedelic meaning-enhancement in enhancing placebo response, the paper explores the mechanisms by which the meaning-amplifying properties of psychedelics might also play a role in enhancing creativity, as well as in effecting mystical-type experiences. The wider social and public-health implications of this hypothesis are discussed, and suggestions are made as to the various ways in which scientific understanding of the meaning-enhancing properties of psychedelics might be advanced and utilized.

The SpikerBox: A Low Cost, Open-Source BioAmplifier for Increasing Public Participation in Neuroscience Inquiry

PubMed Central

Marzullo, Timothy C.; Gage, Gregory J.

2012-01-01

Although people are generally interested in how the brain functions, neuroscience education for the public is hampered by a lack of low cost and engaging teaching materials. To address this, we developed an open-source tool, the SpikerBox, which is appropriate for use in middle/high school educational programs and by amateurs. This device can be used in easy experiments in which students insert sewing pins into the leg of a cockroach, or other invertebrate, to amplify and listen to the electrical activity of neurons. With the cockroach leg preparation, students can hear and see (using a smartphone oscilloscope app we have developed) the dramatic changes in activity caused by touching the mechanosensitive barbs. Students can also experiment with other manipulations such as temperature, drugs, and microstimulation that affect the neural activity. We include teaching guides and other resources in the supplemental materials. These hands-on lessons with the SpikerBox have proven to be effective in teaching basic neuroscience. PMID:22470415

Breadboard Amplifier: Building and Using Simple Electrophysiology Equipment

PubMed Central

Crisp, Kevin M.; Lin, Hunter; Prosper, Issa

2016-01-01

Electrophysiology is a valuable skill for the neuroscientist, but the learning curve for students can be steep. Here we describe a very simple electromyography (EMG) amplifier that can be built from scratch by students with no electronics experience in about 30 minutes, making it ideal for incorporating into a laboratory activity. With few parts and no adjustments except the gain, students can begin physiology experiments quickly while having the satisfaction of having built the equipment themselves. Because the output of the circuit goes to a computer sound card, students can listen to electrophysiological activity as they see it on the computer screen, a feature many of our students greatly appreciated. Various applications are discussed, including dual channel recording, using streaming media platforms with remote lab partners and acquiring data in the field on a smart phone. Our students reported that they enjoyed being able to build a working device and using it to record from their own muscles. PMID:27385921

Ping-pong auto-zero amplifier with glitch reduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larson, Mark R

A ping-pong amplifier with reduced glitching is described. The ping-pong amplifier includes a nulling amplifier coupled to a switching network. The switching network is used to auto-zero a ping amplifier within a ping-pong amplifier. The nulling amplifier drives the output of a ping amplifier to a proper output voltage level during auto-zeroing of the ping amplifier. By being at a proper output voltage level, glitches associated with transitioning between a ping amplifier and a pong amplifier are reduced or eliminated.

Theory of injection locking and rapid start-up of magnetrons, and effects of manufacturing errors in terahertz traveling wave tubes

NASA Astrophysics Data System (ADS)

Pengvanich, Phongphaeth

In this thesis, several contemporary issues on coherent radiation sources are examined. They include the fast startup and the injection locking of microwave magnetrons, and the effects of random manufacturing errors on phase and small signal gain of terahertz traveling wave amplifiers. In response to the rapid startup and low noise magnetron experiments performed at the University of Michigan that employed periodic azimuthal perturbations in the axial magnetic field, a systematic study of single particle orbits is performed for a crossed electric and periodic magnetic field. A parametric instability in the orbits, which brings a fraction of the electrons from the cathode toward the anode, is discovered. This offers an explanation of the rapid startup observed in the experiments. A phase-locking model has been constructed from circuit theory to qualitatively explain various regimes observed in kilowatt magnetron injection-locking experiments, which were performed at the University of Michigan. These experiments utilize two continuous-wave magnetrons; one functions as an oscillator and the other as a driver. Time and frequency domain solutions are developed from the model, allowing investigations into growth, saturation, and frequency response of the output. The model qualitatively recovers many of the phase-locking frequency characteristics observed in the experiments. Effects of frequency chirp and frequency perturbation on the phase and lockability have also been quantified. Development of traveling wave amplifier operating at terahertz is a subject of current interest. The small circuit size has prompted a statistical analysis of the effects of random fabrication errors on phase and small signal gain of these amplifiers. The small signal theory is treated with a continuum model in which the electron beam is monoenergetic. Circuit perturbations that vary randomly along the beam axis are introduced through the dimensionless Pierce parameters describing the beam-wave velocity mismatch (b), the gain parameter (C), and the cold tube circuit loss ( d). Our study shows that perturbation in b dominates the other two in terms of power gain and phase shift. Extensive data show that standard deviation of the output phase is linearly proportional to standard deviation of the individual perturbations in b, C and d.

High power RF solid state power amplifier system

NASA Technical Reports Server (NTRS)

Sims, III, William Herbert (Inventor); Chavers, Donald Gregory (Inventor); Richeson, James J. (Inventor)

2011-01-01

A high power, high frequency, solid state power amplifier system includes a plurality of input multiple port splitters for receiving a high-frequency input and for dividing the input into a plurality of outputs and a plurality of solid state amplifier units. Each amplifier unit includes a plurality of amplifiers, and each amplifier is individually connected to one of the outputs of multiport splitters and produces a corresponding amplified output. A plurality of multiport combiners combine the amplified outputs of the amplifiers of each of the amplifier units to a combined output. Automatic level control protection circuitry protects the amplifiers and maintains a substantial constant amplifier power output.

Simple Demonstration of the Seebeck Effect

ERIC Educational Resources Information Center

Molki, Arman

2010-01-01

In this article we propose a simple and low-cost experimental set-up through which science educators can demonstrate the Seebeck effect using a thermocouple and an instrumentation amplifier. The experiment can be set up and conducted during a 1-hour laboratory session. (Contains 3 tables and 3 figures.)

Proposal for Research on High-Brightness Cathodes for High-Power Free-Electron Lasers (FEL)

DTIC Science & Technology

2013-05-09

recent experiments involving single crystal diamond amplifier cathodes (DAC) at Brookhaven National Laboratory ( BNL ). While the emission surface of our...diamond grain in the entire structure, both surface and interior, is passivated with hydrogen. The aforementioned studies at BNL found that

Cognitive Aspects of Regularity Exhibit When Neighborhood Disappears

ERIC Educational Resources Information Center

Chen, Sau-Chin; Hu, Jon-Fan

2015-01-01

Although regularity refers to the compatibility between pronunciation of character and sound of phonetic component, it has been suggested as being part of consistency, which is defined by neighborhood characteristics. Two experiments demonstrate how regularity effect is amplified or reduced by neighborhood characteristics and reveals the…

Data Literacy is Statistical Literacy

ERIC Educational Resources Information Center

Gould, Robert

2017-01-01

Past definitions of statistical literacy should be updated in order to account for the greatly amplified role that data now play in our lives. Experience working with high-school students in an innovative data science curriculum has shown that teaching statistical literacy, augmented by data literacy, can begin early.

Developing Educational Goals: Insights from a Peer Assisted Teaching Scheme

ERIC Educational Resources Information Center

Ross, Bella; Carbone, Angela; Lindsay, Katherine; Drew, Steve; Phelan, Liam; Cottman, Caroline; Stoney, Sue

2016-01-01

The rapid changes facing higher education are placing increased focus on the quality of the student experience, achieving learning outcomes, and employability expectations. As a result, academics in teaching roles are increasingly measured on performance via student evaluations amplifying attention on professional development initiatives for…

Quasi-one-dimensional modes in strip plates: Theory and experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arreola, A.; Báez, G.; Méndez-Sánchez, R. A.

2014-01-14

Using acoustic resonance spectroscopy we measure the elastic resonances of a strip rectangular plate with all its ends free. The experimental setup consist of a vector network analyzer, a high-fidelity audio amplifier, and electromagnetic-acoustic transducers. The one-dimensional modes are identified from the measured spectra by comparing them with theoretical predictions of compressional and bending modes of the plate modeled as a beam. The agreement between theory and experiment is excellent.

Anesthesia Providers’ Perspectives Regarding Parental Presence During Anesthesia Induction: A Pilot Study

DTIC Science & Technology

1997-05-01

stressful parts of the surgical experience. This stress affects the child, the parent, and the surgical team. Children and parents cdike are often...during episodes of extreme stress only amplifies that stress (Bowlby, 1973). Bowlby studied post World War II orphans in England and observed the...children often find themselves in the middle of warring factions. Any parent or child experiences stress preoperatively. The added dimension of

Q-Band (37-41 GHz) Satellite Beacon Architecture for RF Propagation Experiments

NASA Technical Reports Server (NTRS)

Simmons, Rainee N.; Wintucky, Edwin G.

2012-01-01

In this paper, the design of a beacon transmitter that will be flown as a hosted payload on a geostationary satellite to enable propagation experiments at Q-band (37-41 GHz) frequencies is presented. The beacon uses a phased locked loop stabilized dielectric resonator oscillator and a solid-state power amplifier to achieve the desired output power. The satellite beacon antenna is configured as an offset-fed cut-paraboloidal reflector.

Semiconductor Based Transverse Bragg Resonance (TBR) Optical Amplifiers and Lasers

DTIC Science & Technology

2007-02-14

modes with small modal angles experience zero or very low radiation loss. We call these modes small modal angle (SMA) modes. SMA modes include both...lossless effective index-guided modes and low loss leaky modes. They are almost parallel to the graing and do not radiate significantly. As the modal...angle increases, all the modes experience higher radiation loss. However, around the transverse resonance angle of 13.80, low loss modes exist. These

Q-Band (37 to 41 GHz) Satellite Beacon Architecture for RF Propagation Experiments

NASA Technical Reports Server (NTRS)

Simons, Rainee N.; Wintucky, Edwin G.

2014-01-01

In this paper, the design of a beacon transmitter that will be flown as a hosted payload on a geostationary satellite to enable propagation experiments at Q-band (37 to 41 GHz) frequencies is presented. The beacon uses a phased locked loop stabilized dielectric resonator oscillator and a solid-state power amplifier to achieve the desired output power. The satellite beacon antenna is configured as an offset-fed cutparaboloidal reflector.

Real Time Calibration Method for Signal Conditioning Amplifiers

NASA Technical Reports Server (NTRS)

Medelius, Pedro J. (Inventor); Mata, Carlos T. (Inventor); Eckhoff, Anthony (Inventor); Perotti, Jose (Inventor); Lucena, Angel (Inventor)

2004-01-01

A signal conditioning amplifier receives an input signal from an input such as a transducer. The signal is amplified and processed through an analog to digital converter and sent to a processor. The processor estimates the input signal provided by the transducer to the amplifier via a multiplexer. The estimated input signal is provided as a calibration voltage to the amplifier immediately following the receipt of the amplified input signal. The calibration voltage is amplified by the amplifier and provided to the processor as an amplified calibration voltage. The amplified calibration voltage is compared to the amplified input signal, and if a significant error exists, the gain and/or offset of the amplifier may be adjusted as necessary.

A tunable microstrip SQUID amplifier for the Axion Dark Matter eXperiment (ADMX)

NASA Astrophysics Data System (ADS)

O'Kelley, Sean; Hansen, Jorn; Weingarten, Elan; Mueck, Michael; Hilton, Gene; Clarke, John

2014-03-01

We describe a microstrip SQUID (Superconducting QUantum Interference Device) amplifier (MSA) used as the photon detector in the Axion Dark Matter eXperiment (ADMX). Cooled to 100 mK or lower, an optimized MSA approaches the quantum limit of detection. The axion dark matter is detected via Primakoff conversion to a microwave photon in a high-Q (~ 105) tunable microwave cavity, currently cooled to about 1.6 K, in the presence of a 7-tesla magnetic field. The MSA consists of a square loop of thin Nb film, incorporating two Josephson tunnel junctions with resistive shunts to prevent hysteresis in the current-voltage characteristic. The microstrip is a square Nb coil deposited over an intervening insulating layer. Since the photon frequency is determined by the unknown axion mass, the cavity and amplifier must be tunable over a broad frequency range. Tunability is achieved by terminating the microstrip with a GaAs varactor diode with a voltage-controlled capacitance that enables us to vary the resonance from nearly 1/2 to 1/4 of a wavelength. With the SQUID current-biased in the voltage state, we demonstrate a gain of typically 20 dB over nearly one octave, 415 MHz to 800 MHz. Supported by DOE Grants DE-FG02-97ER41029, DE-FG02-96ER40956, DE-AC52-07NA27344, DE-AC03-76SF00098, NSF grants PHY-1067242 and PHY-1306729, and the Livermore LDRD program.

DPSSL pumped 20-TW Ti:sapphire laser system for DD fusion experiment

NASA Astrophysics Data System (ADS)

Sekine, T.; Hatano, Y.; Takeuchi, Y.; Kawashima, T.

2016-03-01

A diode-pumped solid-state laser (DPSSL) pumped 20-TW output Ti:sapphire laser system has been developed. A diode-pumped Nd:glass laser with output energy of 12.7 J in 527 nm was used as a pump source for a 20-TW Ti:sapphire amplifier. A CeLiB6O10 nonlinear optical crystal was used as a frequency doubler of the Nd:glass DPSSL[1]. Figure 1 shows typical output pulse energy of the 20-TW amplifier as a function of pumping energy and a near field pattern. A 1.65 J pulse energy was obtained by 4.5 J pump energy. The amplified seed pulse is compressed to typically 60 fs as shown in Fig. 1 by a vacuumed pulse compressor with 80% of transmissivity. Encircled energy ratio, into a circled with 8 μm diameter area, of far field pattern focused by off-axis parabolic mirror with F# of 3 is numerically evaluated to 40% at TW class output condition. Then focal intensity would reach to 1018W/cm2. This all- DPSSL system contributes for stable and continual investigation of laser induced plasma experiment. We have succeeded continual and high efficient generation of DD fusion neutron from CD nano-particles by cluster fusion scheme using the 20-TW laser. A yield of ∼105 neutrons per shot was stably observed during continuous 100 shots with repetition rate of 0.1Hz.

Several hundred kHz repetition rate nanosecond pulses amplification in Er-Yb co-doped fiber amplifier

NASA Astrophysics Data System (ADS)

Yang, Weiqiang; Yin, Ke; Zhang, Bin; Xue, Guanghui; Hou, Jing

2014-07-01

We have experimentally investigated several hundred kHz repetition rate 1,550-nm nanosecond pulses amplification in Er-Yb co-doped fiber amplifier (EYDFA). The experimental setup has three stage fiber amplifiers. At the output of the second stage EYDFA, Yb3+ ions induced amplified spontaneous emission (Yb-ASE) is not observed owing to the low pump power. In the third stage EYDFA, a simultaneously seeded 1,064-nm continuous-wave laser is used to control Yb-ASE. Without any additional 1,064-nm signal, significantly backward Yb-ASE which caused loss-induced heat accumulation at the input port of the pump combiner can be observed. The monitored temperature at the input port of the pump combiner rapidly grows from 30 to 80 °C when the pump power is turned from 20 to 32 W. When a 196-mW forward 1,064-nm laser is added, the monitored backward Yb-ASE power is significantly declined, and the monitored temperature is kept below 35 °C. But, the additional signal caused a large power fraction at 1,064 nm in the output laser. In our experiment at the maximum pump power of 48.5 W, the total output power is 20 W with ~6.4-W 1,550-nm pulsed laser and ~13-W 1,064-nm continuous-wave laser.

A Single-Chip CMOS Pulse Oximeter with On-Chip Lock-In Detection.

PubMed

He, Diwei; Morgan, Stephen P; Trachanis, Dimitrios; van Hese, Jan; Drogoudis, Dimitris; Fummi, Franco; Stefanni, Francesco; Guarnieri, Valerio; Hayes-Gill, Barrie R

2015-07-14

Pulse oximetry is a noninvasive and continuous method for monitoring the blood oxygen saturation level. This paper presents the design and testing of a single-chip pulse oximeter fabricated in a 0.35 µm CMOS process. The chip includes photodiode, transimpedance amplifier, analogue band-pass filters, analogue-to-digital converters, digital signal processor and LED timing control. The experimentally measured AC and DC characteristics of individual circuits including the DC output voltage of the transimpedance amplifier, transimpedance gain of the transimpedance amplifier, and the central frequency and bandwidth of the analogue band-pass filters, show a good match (within 1%) with the circuit simulations. With modulated light source and integrated lock-in detection the sensor effectively suppresses the interference from ambient light and 1/f noise. In a breath hold and release experiment the single chip sensor demonstrates consistent and comparable performance to commercial pulse oximetry devices with a mean of 1.2% difference. The single-chip sensor enables a compact and robust design solution that offers a route towards wearable devices for health monitoring.

2.5 Gbit/s Optical Receiver Front-End Circuit with High Sensitivity and Wide Dynamic Range

NASA Astrophysics Data System (ADS)

Zhu, Tiezhu; Mo, Taishan; Ye, Tianchun

2017-12-01

An optical receiver front-end circuit is designed for passive optical network and fabricated in a 0.18 um CMOS technology. The whole circuit consists of a transimpedance amplifier (TIA), a single-ended to differential amplifier and an output driver. The TIA employs a cascode stage as the input stage and auxiliary amplifier to reduce the miller effect. Current injecting technique is employed to enlarge the input transistor's transconductance, optimize the noise performance and overcome the lack of voltage headroom. To achieve a wide dynamic range, an automatic gain control circuit with self-adaptive function is proposed. Experiment results show an optical sensitivity of -28 dBm for a bit error rate of 10-10 at 2.5 Gbit/s and a maxim input optical power of 2 dBm using an external photodiode. The chip occupies an area of 1×0.9 mm2 and consumes around 30 mW from single 1.8 V supply. The front-end circuit can be used in various optical receivers.

A Single-Chip CMOS Pulse Oximeter with On-Chip Lock-In Detection

PubMed Central

He, Diwei; Morgan, Stephen P.; Trachanis, Dimitrios; van Hese, Jan; Drogoudis, Dimitris; Fummi, Franco; Stefanni, Francesco; Guarnieri, Valerio; Hayes-Gill, Barrie R.

2015-01-01

Pulse oximetry is a noninvasive and continuous method for monitoring the blood oxygen saturation level. This paper presents the design and testing of a single-chip pulse oximeter fabricated in a 0.35 µm CMOS process. The chip includes photodiode, transimpedance amplifier, analogue band-pass filters, analogue-to-digital converters, digital signal processor and LED timing control. The experimentally measured AC and DC characteristics of individual circuits including the DC output voltage of the transimpedance amplifier, transimpedance gain of the transimpedance amplifier, and the central frequency and bandwidth of the analogue band-pass filters, show a good match (within 1%) with the circuit simulations. With modulated light source and integrated lock-in detection the sensor effectively suppresses the interference from ambient light and 1/f noise. In a breath hold and release experiment the single chip sensor demonstrates consistent and comparable performance to commercial pulse oximetry devices with a mean of 1.2% difference. The single-chip sensor enables a compact and robust design solution that offers a route towards wearable devices for health monitoring. PMID:26184225

[Continuous registration of micropotentials of the human heart. Initial experiences with a new high resolution ECG amplifier system].

PubMed

Hombach, V; Kebbel, U; Höpp, H W; Winter, U J; Braun, V; Deutsch, H; Hirche, H; Hilger, H H

1982-12-24

A new ECG-amplifier system for recording cardiac microvolt potentials from the body surface is described. The improvement in signal-to-noise ratio was achieved by using specially designed suction electrodes, which were isolated from each other; by applying parallel signal averaging from four electrode pairs via four low-noise amplifiers; and by conducting the registration in Faraday cage. in 14 normal subjects, 12 patients with coronary heart disease and one patient with surgically corrected ventricular septal defect and pulmonary stenosis, pre-P-potentials (possible sinus node activity), His bundle potentials and ventricular late potentials were recorded with differing degrees of success. Variations of the time intervals to the preceding QRS complex were observed within the S-T segment in six of nine patients with demonstrable ventricular late ventricular late potentials. The advantage of such continuously recording ECG system lies in the highly accurate registration of cardiac micropotentials, particularly with ventricular late potentials that are changing in time, whereas the signal-averaging technique does not provide such possibilities.

Multipath interference test method for distributed amplifiers

NASA Astrophysics Data System (ADS)

Okada, Takahiro; Aida, Kazuo

2005-12-01

A method for testing distributed amplifiers is presented; the multipath interference (MPI) is detected as a beat spectrum between the multipath signal and the direct signal using a binary frequency shifted keying (FSK) test signal. The lightwave source is composed of a DFB-LD that is directly modulated by a pulse stream passing through an equalizer, and emits the FSK signal of the frequency deviation of about 430MHz at repetition rate of 80-100 kHz. The receiver consists of a photo-diode and an electrical spectrum analyzer (ESA). The base-band power spectrum peak appeared at the frequency of the FSK frequency deviation can be converted to amount of MPI using a calibration chart. The test method has improved the minimum detectable MPI as low as -70 dB, compared to that of -50 dB of the conventional test method. The detailed design and performance of the proposed method are discussed, including the MPI simulator for calibration procedure, computer simulations for evaluating the error caused by the FSK repetition rate and the fiber length under test and experiments on singlemode fibers and distributed Raman amplifier.

Designing Polymerase Chain Reaction (PCR) Primer Multiplexes in the Forensic Laboratory

ERIC Educational Resources Information Center

Elkins, Kelly M.

2011-01-01

The polymerase chain reaction (PCR) is a common experiment in upper-level undergraduate biochemistry, molecular biology, and forensic laboratory courses as reagents and thermocyclers have become more affordable for institutions. Typically, instructors design PCR primers to amplify the region of interest and the students prepare their samples for…

On the Bias-Amplifying Effect of Near Instruments in Observational Studies

ERIC Educational Resources Information Center

Steiner, Peter M.; Kim, Yongnam

2014-01-01

In contrast to randomized experiments, the estimation of unbiased treatment effects from observational data requires an analysis that conditions on all confounding covariates. Conditioning on covariates can be done via standard parametric regression techniques or nonparametric matching like propensity score (PS) matching. The regression or…

Instructional Technology and Worker Learning Needs. Contractor Report.

ERIC Educational Resources Information Center

Kearsley, Greg

The effects of instructional technology on learning are determined by the extent to which hardware and software amplify the basic capabilities of an instructor. Experience indicates that rational considerations such as cost-effectiveness are not usually the primary factors in making decisions about use of technology in training. Most large…

Experiments with a Loudspeaker

ERIC Educational Resources Information Center

Kraftmakher, Yaakov

2009-01-01

A common moving-coil loudspeaker is useful for learning harmonic motion. A simple optical method is used to observe free and forced oscillations of the diaphragm of a loudspeaker. With a lock-in amplifier and data-acquisition system, the frequency response of the loudspeaker and its electrical impedance are automatically recorded versus frequency.…

Games and (Preparation for Future) Learning

ERIC Educational Resources Information Center

Hammer, Jessica; Black, John

2009-01-01

What makes games effective for learning? The authors argue that games provide vicarious experiences for players, which then amplify the effects of future, formal learning. However, not every game succeeds in doing so! Understanding why some games succeed and others fail at this task means investigating both a given game's design and the…

Amplify Errors to Minimize Them

ERIC Educational Resources Information Center

Stewart, Maria Shine

2009-01-01

In this article, the author offers her experience of modeling mistakes and writing spontaneously in the computer classroom to get students' attention and elicit their editorial response. She describes how she taught her class about major sentence errors--comma splices, run-ons, and fragments--through her Sentence Meditation exercise, a rendition…

High-energy ultra-short pulse thin-disk lasers: new developments and applications

NASA Astrophysics Data System (ADS)

Michel, Knut; Klingebiel, Sandro; Schultze, Marcel; Tesseit, Catherine Y.; Bessing, Robert; Häfner, Matthias; Prinz, Stefan; Sutter, Dirk; Metzger, Thomas

2016-03-01

We report on the latest developments at TRUMPF Scientific Lasers in the field of ultra-short pulse lasers with highest output energies and powers. All systems are based on the mature and industrialized thin-disk technology of TRUMPF. Thin Yb:YAG disks provide a reliable and efficient solution for power and energy scaling to Joule- and kW-class picosecond laser systems. Due to its efficient one dimensional heat removal, the thin-disk exhibits low distortions and thermal lensing even when pumped under extremely high pump power densities of 10kW/cm². Currently TRUMPF Scientific Lasers develops regenerative amplifiers with highest average powers, optical parametric amplifiers and synchronization schemes. The first few-ps kHz multi-mJ thin-disk regenerative amplifier based on the TRUMPF thindisk technology was developed at the LMU Munich in 20081. Since the average power and energy have continuously been increased, reaching more than 300W (10kHz repetition rate) and 200mJ (1kHz repetition rate) at pulse durations below 2ps. First experiments have shown that the current thin-disk technology supports ultra-short pulse laser solutions >1kW of average power. Based on few-picosecond thin-disk regenerative amplifiers few-cycle optical parametric chirped pulse amplifiers (OPCPA) can be realized. These systems have proven to be the only method for scaling few-cycle pulses to the multi-mJ energy level. OPA based few-cycle systems will allow for many applications such as attosecond spectroscopy, THz spectroscopy and imaging, laser wake field acceleration, table-top few-fs accelerators and laser-driven coherent X-ray undulator sources. Furthermore, high-energy picosecond sources can directly be used for a variety of applications such as X-ray generation or in atmospheric research.

Simple nonlinearity evaluation and modeling of low-noise amplifiers with application to radio astronomy receivers.

PubMed

Casas, F J; Pascual, J P; de la Fuente, M L; Artal, E; Portilla, J

2010-07-01

This paper describes a comparative nonlinear analysis of low-noise amplifiers (LNAs) under different stimuli for use in astronomical applications. Wide-band Gaussian-noise input signals, together with the high values of gain required, make that figures of merit, such as the 1 dB compression (1 dBc) point of amplifiers, become crucial in the design process of radiometric receivers in order to guarantee the linearity in their nominal operation. The typical method to obtain the 1 dBc point is by using single-tone excitation signals to get the nonlinear amplitude to amplitude (AM-AM) characteristic but, as will be shown in the paper, in radiometers, the nature of the wide-band Gaussian-noise excitation signals makes the amplifiers present higher nonlinearity than when using single tone excitation signals. Therefore, in order to analyze the suitability of the LNA's nominal operation, the 1 dBc point has to be obtained, but using realistic excitation signals. In this work, an analytical study of compression effects in amplifiers due to excitation signals composed of several tones is reported. Moreover, LNA nonlinear characteristics, as AM-AM, total distortion, and power to distortion ratio, have been obtained by simulation and measurement with wide-band Gaussian-noise excitation signals. This kind of signal can be considered as a limit case of a multitone signal, when the number of tones is very high. The work is illustrated by means of the extraction of realistic nonlinear characteristics, through simulation and measurement, of a 31 GHz back-end module LNA used in the radiometer of the QUIJOTE (Q U I JOint TEnerife) CMB experiment.

Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

PubMed Central

Cocco, Emiliano; Lopez, Salvatore; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L; Menderes, Gulden; Zammataro, Luca; Buza, Natalia; Hui, Pei; Wong, Serena; Zhao, Siming; Bai, Yalai; Rimm, David L; Ratner, Elena; Litkouhi, Babak; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Santin, Alessandro D

2016-01-01

Background: Clinical options for patients harbouring advanced/recurrent uterine serous carcinoma (USC), an aggressive variant of endometrial tumour, are very limited. Next-generation sequencing (NGS) data recently demonstrated that cyclin E1 (CCNE1) gene amplification and pik3ca driver mutations are common in USC and may therefore represent ideal therapeutic targets. Methods: Cyclin E1 expression was evaluated by immunohistochemistry (IHC) on 95 USCs. The efficacy of the cyclin-dependent kinase 2/9 inhibitor CYC065 was assessed on multiple primary USC cell lines with or without CCNE1 amplification. Cell-cycle analyses and knockdown experiments were performed to assess CYC065 targeting specificity. Finally, the in vitro and in vivo activity of CYC065, Taselisib (a PIK3CA inhibitor) and their combinations was tested on USC xenografts derived from CCNE1-amplified/pik3ca-mutated USCs. Results: We found that 89.5% of the USCs expressed CCNE1. CYC065 blocked cells in the G1 phase of the cell cycle and inhibited cell growth specifically in CCNE1-overexpressing USCs. Cyclin E1 knockdown conferred increased resistance to CYC065, whereas CYC065 treatment of xenografts derived from CCNE1-amplified USCs significantly reduced tumour growth. The combination of CYC065 and Taselisib demonstrated synergistic effect in vitro and was significantly more effective than single-agent treatment in decreasing tumour growth in xenografts of CCNE1-amplified/pik3ca-mutated USCs. Conclusions: Dual CCNE1/PIK3CA blockade may represent a novel therapeutic option for USC patients harbouring recurrent CCNE1-amplified/pi3kca-mutated tumours. PMID:27351214

Development of a 150-GHz MMIC Module Prototype for Large-Scale CMB Radiation

NASA Technical Reports Server (NTRS)

Kangaslahti, Pekka P.; Samoska, Lorene A.; Gaier, Todd C.; Soria, Mary M.; Lau, Judy M.; Sieth, Matthew M.; VanWinkle, Daniel; Tantawi, Sami

2011-01-01

HEMT-based receiver arrays with excellent noise and scalability are already starting to be manufactured at 100 GHz, but the advances in technology should make it possible to develop receiver modules with even greater operation frequency up to 200 GHz. A prototype heterodyne amplifier module has been developed for operation from 140 to 170 GHz using monolithic millimeter-wave integrated circuit (MMIC) low-noise InP high electron mobility transistor (HEMT) amplifiers. The compact, scalable module is centered on the 150-GHz atmospheric window using components known to operate well at these frequencies. Arrays equipped with hundreds of these modules can be optimized for many different astrophysical measurement techniques, including spectroscopy and interferometry. This module is a heterodyne receiver module that is extremely compact, and makes use of 35-nm InP HEMT technology, and which has been shown to have excellent noise temperatures when cooled cryogenically to 30 K. This reduction in system noise over prior art has been demonstrated in commercial mixers (uncooled) at frequencies of 160-180 GHz. The module is expected to achieve a system noise temperature of 60 K when cooled. An MMIC amplifier module has been designed to demonstrate the feasibility of expanding heterodyne amplifier technology to the 140 to 170-GHz frequency range for astronomical observations. The miniaturization of many standard components and the refinement of RF interconnect technology have cleared the way to mass-production of heterodyne amplifier receivers, making it a feasible technology for many large-population arrays. This work furthers the recent research efforts in compact coherent receiver modules, including the development of the Q/U Imaging ExperimenT (QUIET) modules centered at 40 and 90 GHz, and the production of heterodyne module prototypes at 90 GHz.

Experimental characterization of the saturating, near infrared, self-amplified spontaneous emission free electron laser: Analysis of radiation properties and electron beam dynamics

NASA Astrophysics Data System (ADS)

Murokh, Alex

2002-01-01

In this work, the main results of the VISA experiment (Visible to Infrared SASE Amplifier) are presented and analyzed. The purpose of the experiment was to build a state-of-the-art single pass self-amplified spontaneous emission (SASE) free electron laser (FEL) based on a high brightness electron beam, and characterize its operation, including saturation, in the near infrared spectral region. This experiment was hosted by Accelerator Test Facility (ATF) at Brookhaven National Laboratory, which is a users facility that provides high brightness relativistic electron beams generated with the photoinjector. During the experiment, SASE FEL performance was studied in two regimes: a long bunch, lower gain operation; and a short bunch high gain regime. The transition between the two conditions was possible due to a novel bunch compression mechanism, which was discovered in the course of the experiment. This compression allowed the variation of peak current in the electron beam before it was launched into the 4-m VISA undulator. In the long bunch regime, a SASE FEL power gain length of 29 cm was obtained, and the generated radiation spectral and statistical properties were characterized. In the short bunch regime, a power gain length of under 18 cm was achieved at 842 nm, which is at least a factor of two shorter than ever previously achieved in this spectral range. Further, FEL saturation was obtained before the undulator exit. The FEL system's performance was measured along the length of the VISA undulator, and in the final state. Statistical, spectral and angular properties of the short bunch SASE radiation have been measured in the exponential gain regime, and at saturation. One of the most important aspects of the data analysis presented in this thesis was the development and use of start-to-end numerical simulations of the experiment. The dynamics of the ATF electron beam was modeled starting from the photocathode, through acceleration, transport, and inside the VISA undulator. The model allowed simulation of SASE process for different beam conditions, including the effects of the novel bunch compression mechanism on the electron beam 6-D phase space distribution. The numerical simulations displayed an excellent agreement with the experimental data, and became key to understanding complex dynamics of the SASE FEL process at VISA.

Cross-flow vortex structure and transition measurements using multi-element hot films

NASA Technical Reports Server (NTRS)

Agarwal, Naval K.; Mangalam, Siva M.; Maddalon, Dal V.; Collier, Fayette S., Jr.

1991-01-01

An experiment on a 45-degree swept wing was conducted to study three-dimensional boundary-layer characteristics using surface-mounted, micro-thin, multi-element hot-film sensors. Cross-flow vortex structure and boundary-layer transition were measured from the simultaneously acquired signals of the hot films. Spanwise variation of the root-mean-square (RMS) hot-film signal show a local minima and maxima. The distance between two minima corresponds to the stationary cross-flow vortex wavelength and agrees with naphthalene flow-visualization results. The chordwise and spanwise variation of amplified traveling (nonstationary) cross-flow disturbance characteristics were measured as Reynolds number was varied. The frequency of the most amplified cross-flow disturbances agrees with linear stability theory.

Spectrally tunable, temporally shaped parametric front end to seed high-energy Nd:glass laser systems

DOE PAGES

Dorrer, C.; Consentino, A.; Cuffney, R.; ...

2017-10-18

Here, we describe a parametric-amplification–based front end for seeding high-energy Nd:glass laser systems. The front end delivers up to 200 mJ by parametric amplification in 2.5-ns flat-in-time pulses tunable over more than 15 nm. Spectral tunability over a range larger than what is typically achieved by laser media at similar energy levels is implemented to investigate cross-beam energy transfer in multibeam target experiments. The front-end operation is simulated to explain the amplified signal’s sensitivity to the input pump and signal. A large variety of amplified waveforms are generated by closed-loop pulse shaping. Various properties and limitations of this front endmore » are discussed.« less

Spectrally tunable, temporally shaped parametric front end to seed high-energy Nd:glass laser systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dorrer, C.; Consentino, A.; Cuffney, R.

Here, we describe a parametric-amplification–based front end for seeding high-energy Nd:glass laser systems. The front end delivers up to 200 mJ by parametric amplification in 2.5-ns flat-in-time pulses tunable over more than 15 nm. Spectral tunability over a range larger than what is typically achieved by laser media at similar energy levels is implemented to investigate cross-beam energy transfer in multibeam target experiments. The front-end operation is simulated to explain the amplified signal’s sensitivity to the input pump and signal. A large variety of amplified waveforms are generated by closed-loop pulse shaping. Various properties and limitations of this front endmore » are discussed.« less

A high gain free electron laser amplifier design for the Alcator-C tokamak. [FRED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jong, R.A.

1987-02-01

We describe an improved wiggler tapering algorithm and the resulting wiggler design for a high-gain free electron laser amplifier to be used for plasma heating and current drive experiments in the Alcator-C tokamak. Unlike the original, this new design limits the growth of the shot noise to insignificant levels. The design goal of at least 8 GW of peak power in the TE/sub 01/ mode was achieved with a 3 kA electron beam with energies in the 7 to 9 MeV range and a beam brightness of 10/sup 5/ A/(rad-cm)/sup 2/. The wiggler was 5 m long with a wigglermore » wavelength of 8 cm.« less

Power scaling limits in high power fiber amplifiers due to transverse mode instability, thermal lensing, and fiber mechanical reliability

NASA Astrophysics Data System (ADS)

Zervas, Michalis N.

2018-02-01

We introduced a simple formula providing the mode-field diameter shrinkage, due to heat load in fiber amplifiers, and used it to compare the traditional thermal-lensing power limit (PTL) to a newly developed transverse-mode instability (TMI) power limit (PTMI), giving a fixed ratio of PTMI/PTL≍0.6, in very good agreement with experiment. Using a failure-in-time analysis we also introduced a new power limiting factor due to mechanical reliability of bent fibers. For diode (tandem) pumping power limits of 28kW (52kW) are predicted. Setting a practical limit of maximum core diameter to 35μm, the limits reduce to 15kW (25kW).

500 km unrepeatered 200 Gbit·s-1 transmission over a G.652-compliant ultra-low loss fiber only

NASA Astrophysics Data System (ADS)

Gainov, V. V.; Gurkin, N. V.; Lukinih, S. N.; Shikhaliev, I. I.; Skvortsov, P. I.; Makovejs, S.; Akopov, S. G.; Ten, S. Y.; Nanii, O. E.; Treshchikov, V. N.

2015-06-01

In this work we experimentally demonstrate 200 Gb·s-1 (2  ×  100 G) unrepeatered transmission over 502.1 km using a dual polarization quadrature phase-shift-keyed (DP-QPSK) format and real-time processing. Such ultra-long distance is enabled by the use of high-performance 100 G DP-QPSK transponders (the required optical signal-to-noise ratio is 12 dB), Corning® SMF-28® ULL fiber (the average attenuation of the spools used in this experiment ~0.160 dB km-1), and optimization of remotely pumped optical amplifiers, bidirectional Raman amplifiers, and dispersion precompensation.

Hybrid chirped pulse amplification system

DOEpatents

Barty, Christopher P.; Jovanovic, Igor

2005-03-29

A hybrid chirped pulse amplification system wherein a short-pulse oscillator generates an oscillator pulse. The oscillator pulse is stretched to produce a stretched oscillator seed pulse. A pump laser generates a pump laser pulse. The stretched oscillator seed pulse and the pump laser pulse are directed into an optical parametric amplifier producing an optical parametric amplifier output amplified signal pulse and an optical parametric amplifier output unconverted pump pulse. The optical parametric amplifier output amplified signal pulse and the optical parametric amplifier output laser pulse are directed into a laser amplifier producing a laser amplifier output pulse. The laser amplifier output pulse is compressed to produce a recompressed hybrid chirped pulse amplification pulse.

2 micron femtosecond fiber laser

DOEpatents

Liu, Jian; Wan, Peng; Yang, Lihmei

2014-07-29

Methods and systems for generating femtosecond fiber laser pulses are disclose, including generating a signal laser pulse from a seed laser oscillator; using a first amplifier stage comprising an input and an output, wherein the signal laser pulse is coupled into the input of the first stage amplifier and the output of the first amplifier stage emits an amplified and stretched signal laser pulse; using an amplifier chain comprising an input and an output, wherein the amplified and stretched signal laser pulse from the output of the first amplifier stage is coupled into the input of the amplifier chain and the output of the amplifier chain emits a further amplified, stretched signal laser pulse. Other embodiments are described and claimed.

SQUARE WAVE AMPLIFIER

DOEpatents

Leavitt, M.A.; Lutz, I.C.

1958-08-01

An amplifier circuit is described for amplifying sigmals having an alternating current component superimposed upon a direct current component, without loss of any segnnent of the alternating current component. The general circuit arrangement includes a vibrator, two square wave amplifiers, and recombination means. The amplifier input is connected to the vibrating element of the vibrator and is thereby alternately applied to the input of each square wave amplifier. The detailed circuitry of the recombination means constitutes the novelty of the annplifier and consists of a separate, dual triode amplifier coupled to the output of each square wave amplifier with a recombination connection from the plate of one amplifier section to a grid of one section of the other amplifier. The recombination circuit has provisions for correcting distortion caused by overlapping of the two square wave voltages from the square wave amplifiers.

NASA developments in solid state power amplifiers

NASA Technical Reports Server (NTRS)

Leonard, Regis F.

1990-01-01

Over the last ten years, NASA has undertaken an extensive program aimed at development of solid state power amplifiers for space applications. Historically, the program may be divided into three phases. The first efforts were carried out in support of the advanced communications technology satellite (ACTS) program, which is developing an experimental version of a Ka-band commercial communications system. These first amplifiers attempted to use hybrid technology. The second phase was still targeted at ACTS frequencies, but concentrated on monolithic implementations, while the current, third phase, is a monolithic effort that focusses on frequencies appropriate for other NASA programs and stresses amplifier efficiency. The topics covered include: (1) 20 GHz hybrid amplifiers; (2) 20 GHz monolithic MESFET power amplifiers; (3) Texas Instruments' (TI) 20 GHz variable power amplifier; (4) TI 20 GHz high power amplifier; (5) high efficiency monolithic power amplifiers; (6) GHz high efficiency variable power amplifier; (7) TI 32 GHz monolithic power amplifier performance; (8) design goals for Hughes' 32 GHz variable power amplifier; and (9) performance goals for Hughes' pseudomorphic 60 GHz power amplifier.

The Sound-Amplified Environment and Reading Achievement in Elementary Students

ERIC Educational Resources Information Center

Betebenner, Elizabeth Whytlaw

2011-01-01

This study was designed to address the result using sound enhancement technology in classrooms as a method of enhancing the auditory experience for students seated in the rear sections of classrooms. Previous research demonstrated the efficacy of using sound distribution systems (SDS) in real time to enhance speech perception (Anderson &…

The Organization of Social Education in Paul Natorp's Creativity

ERIC Educational Resources Information Center

Belentsov, Sergei I.; Okulich-Kazarin, Valery; Dyumina, Svetlana V.; Kuznetsova, Alesya A.

2017-01-01

The interest in a problem of social education amplifies in the period of considerable changes in society. It is not casual as it substantially causes nature of development of society, influencing process of socialization of younger generations, formation of mechanisms of transfer of social experience and traditions. Social and pedagogical…

Teaching, Technology, and the Art of the Deal

ERIC Educational Resources Information Center

Schieberl, Jeffrey; Rainey, Michael; Palmer, Lynda

2014-01-01

This paper illustrates a teaching innovation that took a traditional role playing exercise based on a case study and added some nuances that amplified the learning experience. The example illustrated in this paper was a didactic negotiation exercise intended to teach simple, basic negotiation principles like zone of possible agreement (ZOPA),…

Localization in Multiple Source Environments: Localizing the Missing Source

DTIC Science & Technology

2007-02-01

volunteer listeners (3 males and 3 females, 19-24 years of age ), participated in the experiment. All had normal hearing (au- diometric thresholds < 15...were routed from a control computer to a Mark of the Unicorn digital-to-analog con- verter (MOTU 24 I/O), then through a bank of amplifiers (Crown Model

Beer and Fast Cars: How Brewers Target Blue-collar Youth through Motor Sport Sponsorships.

ERIC Educational Resources Information Center

Buchanan, David R.; Lev, Jane

This study explored how motor sports sponsorships complement and amplify the brewers' media campaigns by joining masculinity, risk, excitement, and beer in the actual "lived" experiences of potential consumers. To document industry expenditures and justifications for motor sports sponsorship, trade journals and newsletters (N=25) and…

Inferior Frontal Sensitivity to Common Speech Sounds Is Amplified by Increasing Word Intelligibility

ERIC Educational Resources Information Center

Vaden, Kenneth I., Jr.; Kuchinsky, Stefanie E.; Keren, Noam I.; Harris, Kelly C.; Ahlstrom, Jayne B.; Dubno, Judy R.; Eckert, Mark A.

2011-01-01

The left inferior frontal gyrus (LIFG) exhibits increased responsiveness when people listen to words composed of speech sounds that frequently co-occur in the English language (Vaden, Piquado, & Hickok, 2011), termed high phonotactic frequency (Vitevitch & Luce, 1998). The current experiment aimed to further characterize the relation of…

Experiments and Numerical Simulation of Mixing under Supercritical Conditions (PREPRINT)

DTIC Science & Technology

2011-02-08

prescribed phase between them. The signals were then sent to two amplifiers (Krohn-Hite model 7500 and a Trek model PZD2000A), one for each piezo... NASA Ames/Stanford Univ., 1999. [61] C. Segal and SA Polikhov. Subcritical to supercritical mixing. Physics of Fluids, 20:052101, 2008. [62] L. Selle and

The Effect of Climbing Wall Use on the Grip Strength of Fourth-Grade Students

ERIC Educational Resources Information Center

Lirgg, Cathy D.; Dibrezzo, Ro; Gray, Michelle; Esslinger, Travis

2011-01-01

Physical educators are challenged to provide quality experiences that are fun for their students, enhance fitness levels, and build confidence. These challenges are amplified with the current decrease in activity levels of American youth. A possible solution to enhancing physical activity engagement in children is to incorporate climbing walls…

Comparison of RAPD Linkage Maps Constructed For a Single Longleaf Pine From Both Haploid and Diploid Mapping Populations

Treesearch

Thomas L. Kubisiak; C.Dana Nelson; W.L. Name; M. Stine

1996-01-01

Considerable concern has been voiced regarding the reproducibility/transferability of RAPD markers across different genetic backgrounds in genetic mapping experiments. Therefore, separate gametic subsets (mapping populations) were used to construct individual random amplified polymorphic DNA (RAPD) linkage maps for a single longleaf pine (Pinus palustris...

Carrier-envelope phase-controlled quantum interference in optical poling.

PubMed

Adachi, Shunsuke; Kobayashi, Takayoshi

2005-04-22

We demonstrate the efficiency of the optical poling process that depends on the CE phase-controlled quantum interference. For the experiment we employed our noncollinear optical parametric amplifier system for the self-stabilization of the CE phase, with the f-to-2f spectral interferometry system to control the CE phase.

High-reflectivity phase conjugation using Brillouin preamplification.

PubMed

Ridley, K D; Scott, A M

1990-07-15

We describe experiments in which a weak laser pulse is phase conjugated by using a high-gain Brillouin amplifier in front of a stimulated Brillouin scattering phase-conjugate mirror. We observe phase conjugation with signal energies as low as 3 x 10(-13) J and with a maximum reflection coefficient of 2 x 10(8).

Measurements and Studies of Secondary Electron Emission of Diamond Amplified Photocathode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu,Q.

2008-10-01

The Diamond Amplified Photocathode (DAP) is a novel approach to generating electrons. By following the primary electron beam, which is generated by traditional electron sources, with an amplifier, the electron beam available to the eventual application is increased by 1 to 2 orders of magnitude in current. Diamond has a very wide band gap of 5.47eV which allows for a good negative electron affinity with simple hydrogenation, diamond can hold more than 2000MV/m field before breakdown. Diamond also provides the best rigidity among all materials. These two characters offer the capability of applying high voltage across very thin diamond filmmore » to achieve high SEY and desired emission phase. The diamond amplifier also is capable of handling a large heat load by conduction and sub-nanosecond pulse input. The preparation of the diamond amplifier includes thinning and polishing, cleaning with acid etching, metallization, and hydrogenation. The best mechanical polishing available can provide high purity single crystal diamond films with no less than 100 {micro}m thickness and <15 nm Ra surface roughness. The ideal thickness for 700MHz beam is {approx}30 {micro}m, which requires further thinning with RIE or laser ablation. RIE can achieve atomic layer removal precision and roughness eventually, but the time consumption for this procedure is very significant. Laser ablation proved that with <266nm ps laser beam, the ablation process on the diamond can easily achieve removing a few microns per hour from the surface and <100nm roughness. For amplifier application, laser ablation is an adequate and efficient process to make ultra thin diamond wafers following mechanical polishing. Hydrogenation will terminate the diamond surface with monolayer of hydrogen, and form NEA so that secondary electrons in the conduction band can escape into the vacuum. The method is using hydrogen cracker to strike hydrogen atoms onto the bare diamond surface to form H-C bonds. Two independent experiments were carried out to determine the transport of the electrons within the diamond and their emission at the surface. In transmission mode measurements, the diamond amplifier was coated with metal on both sides, so results simply depend only on the electron transport within the diamond. The SEY for this mode provides one secondary electron per 20eV energy, which gives the gain of more than 200 for 4.7keV (effective energy) primary electrons under 2MV/m. Laser detrapping can help the signal maintain the gain with lops pulse and duty cycle of 1.67 x 10{sup -7}. In emission mode measurements, in which the diamond is prepared as in the actual application, the SEY is {approx}20 for 700eV (effective energy) primary electrons under 1.21MV/m. The electric field applied and the primary electron energy is limited by the experiment setup, but the results show good trend toward large gain under high field. Thermal emittance of the diamond secondary emission is critical for the beam application. A careful design is setup to measure with very fine precision and accuracy of 0.01eV.« less

Theory of parametrically amplified electron-phonon superconductivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babadi, Mehrtash; Knap, Michael; Martin, Ivar

2017-07-01

Ultrafast optical manipulation of ordered phases in strongly correlated materials is a topic of significant theoretical, experimental, and technological interest. Inspired by a recent experiment on light-induced superconductivity in fullerenes [M. Mitrano et al., Nature (London) 530, 461 (2016)], we develop a comprehensive theory of light-induced superconductivity in driven electron-phonon systemswith lattice nonlinearities. In analogy with the operation of parametric amplifiers, we show how the interplay between the external drive and lattice nonlinearities lead to significantly enhanced effective electron-phonon couplings. We provide a detailed and unbiased study of the nonequilibrium dynamics of the driven system using the real-time Green's functionmore » technique. To this end, we develop a Floquet generalization of the Migdal-Eliashberg theory and derive a numerically tractable set of quantum Floquet-Boltzmann kinetic equations for the coupled electron-phonon system. We study the role of parametric phonon generation and electronic heating in destroying the transient superconducting state. Finally, we predict the transient formation of electronic Floquet bands in time-and angle-resolved photoemission spectroscopy experiments as a consequence of the proposed mechanism.« less

Further understanding incivility in the workplace: The effects of gender, agency, and communion.

PubMed

Gabriel, Allison S; Butts, Marcus M; Yuan, Zhenyu; Rosen, Rebecca L; Sliter, Michael T

2018-04-01

Research conducted on workplace incivility-a low intensity form of deviant behavior-has generally shown that women report higher levels of incivility at work. However, to date, it is unclear as to whether women are primarily treated uncivilly by men (i.e., members of the socially dominant group/out-group) or other women (i.e., members of in-group) in organizations. In light of different theorizing surrounding gender and incivility, we examine whether women experience increased incivility from other women or men, and whether this effect is amplified for women who exhibit higher agency and less communion at work given that these traits and behaviors violate stereotypical gender norms. Across three complementary studies, results indicate that women report experiencing more incivility from other women than from men, with this effect being amplified for women who are more agentic at work. Further, agentic women who experience increased female-instigated incivility from their coworkers report lower well-being (job satisfaction, psychological vitality) and increased work withdrawal (turnover intentions). Theoretical implications tied to gender and incivility are discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Reviews Book: The Quantum Story: A History in 40 Moments Resource: Down2Earth Equipment: Irwin Signal Generator/Power Amplifier Book: Laboratory Experiments in Physics for Modern Astronomy Book: Heart of Darkness Book: The Long Road to Stockholm Book: The Address Book: Our Place in the Scheme of Things Equipment: TI-Nspire Datalogger/Calculator Web Watch

NASA Astrophysics Data System (ADS)

2013-07-01

WE RECOMMEND The Quantum Story: A History in 40 Moments Dip into this useful and accessible guide to quantum theory Down2Earth Astronomical-science resource enables students to pursue real, hands-on science, whatever the weather Irwin Signal Generator/Power Amplifier Students enjoy the novelty factor of versatile, affordable kit Laboratory Experiments in Physics for Modern Astronomy Book of experiments would make good supplementary material Heart of Darkness: Unravelling the Mysteries of the Invisible Universe Accessible and distinctive account of cosmology impresses The Long Road to Stockholm: The Story of MRI—An Autobiography Fascinating book tells personal and scientific stories side by side WORTH A LOOK The Address Book: Our Place in the Scheme of Things Entertaining and well-written essays offer insights and anecdotes TI-Nspire Datalogger/Calculator Challenging interface gives this kit a steep learning curve, but once overcome, results are good WEB WATCH Light-beam app game leaves little impression, while astronomy and astrophysics projects provide much-needed resources

Solid-state repetitive generator with a gyromagnetic nonlinear transmission line operating as a peak power amplifier

NASA Astrophysics Data System (ADS)

Gusev, A. I.; Pedos, M. S.; Rukin, S. N.; Timoshenkov, S. P.

2017-07-01

In this work, experiments were made in which gyromagnetic nonlinear transmission line (NLTL) operates as a peak power amplifier of the input pulse. At such an operating regime, the duration of the input pulse is close to the period of generated oscillations, and the main part of the input pulse energy is transmitted only to the first peak of the oscillations. Power amplification is achieved due to the voltage amplitude of the first peak across the NLTL output exceeding the voltage amplitude of the input pulse. In the experiments, the input pulse with an amplitude of 500 kV and a half-height pulse duration of 7 ns is applied to the NLTL with a natural oscillation frequency of ˜300 MHz. At the output of the NLTL in 40 Ω coaxial transmission line, the pulse amplitude is increased to 740 kV and the pulse duration is reduced to ˜2 ns, which correspond to power amplification of the input pulse from ˜6 to ˜13 GW. As a source of input pulses, a solid-state semiconductor opening switch generator was used, which allowed carrying out experiments at pulse repetition frequency up to 1 kHz in the burst mode of operation.

PULSE AMPLIFIER

DOEpatents

Johnstone, C.W.

1958-06-17

The improvement of pulse amplifiers used with scintillation detectors is described. The pulse amplifier circuit has the advantage of reducing the harmful effects of overloading cause by large signal inputs. In general the pulse amplifier circuit comprises two amplifier tubes with the input pulses applied to one amplifier grid and coupled to the second amplifier tube through a common cathode load. The output of the second amplifier is coupled from the plate circuit to a cathode follower tube grid and a diode tube in connected from grid to cathode of the cathode follower tube. Degenerative feedback is provided in the second amplifier by coupling a signal from the cathode follower cathode to the second amplifier grid. The circuit proqides moderate gain stability, and overload protection for subsequent pulse circuits.

Towards Quantum Experiments with Human Eyes as Detectors Based on Cloning via Stimulated Emission

NASA Astrophysics Data System (ADS)

Sekatski, Pavel; Brunner, Nicolas; Branciard, Cyril; Gisin, Nicolas; Simon, Christoph

2009-09-01

We show theoretically that a large Bell inequality violation can be obtained with human eyes as detectors, in a “micro-macro” experiment where one photon from an entangled pair is greatly amplified via stimulated emission. The violation is robust under photon loss. This leads to an apparent paradox, which we resolve by noting that the violation proves the existence of entanglement before the amplification. The same is true for the micro-macro experiments performed so far with conventional detectors. However, we also prove that there is genuine micro-macro entanglement even for high loss.

Harvesting wind energy to detect weak signals using mechanical stochastic resonance.

PubMed

Breen, Barbara J; Rix, Jillian G; Ross, Samuel J; Yu, Yue; Lindner, John F; Mathewson, Nathan; Wainwright, Elliot R; Wilson, Ian

2016-12-01

Wind is free and ubiquitous and can be harnessed in multiple ways. We demonstrate mechanical stochastic resonance in a tabletop experiment in which wind energy is harvested to amplify weak periodic signals detected via the movement of an inverted pendulum. Unlike earlier mechanical stochastic resonance experiments, where noise was added via electrically driven vibrations, our broad-spectrum noise source is a single flapping flag. The regime of the experiment is readily accessible, with wind speeds ∼20 m/s and signal frequencies ∼1 Hz. We readily obtain signal-to-noise ratios on the order of 10 dB.

A novel survivable WDM passive optical networks

NASA Astrophysics Data System (ADS)

Cheng, Xiaofei; Fang, Qin; Zhang, Yong; Chen, Bin; Lu, Fucai

2008-11-01

We propose a novel survivable wavelength-division multiplexed-passive optical network (WDM-PON) based on an N × N cyclic array waveguide grating (AWG) and reflective semiconductor optical amplifiers (RSOAs). ONUs are grouped and connected with extra connection fibres (CFs). Protection resources are provided mutually in ONU pairs. The characteristics of the proposed survivable WDM-PON and wavelength routing scheme are analyzed. Experiments of 10- Gb/s downstream and 1.25-Gb/s upstream transmission experiments are demonstrated to verify our proposed scheme.

Photon Statistics of Propagating Thermal Microwaves.

PubMed

Goetz, J; Pogorzalek, S; Deppe, F; Fedorov, K G; Eder, P; Fischer, M; Wulschner, F; Xie, E; Marx, A; Gross, R

2017-03-10

In experiments with superconducting quantum circuits, characterizing the photon statistics of propagating microwave fields is a fundamental task. We quantify the n^{2}+n photon number variance of thermal microwave photons emitted from a blackbody radiator for mean photon numbers, 0.05≲n≲1.5. We probe the fields using either correlation measurements or a transmon qubit coupled to a microwave resonator. Our experiments provide a precise quantitative characterization of weak microwave states and information on the noise emitted by a Josephson parametric amplifier.

Photon Statistics of Propagating Thermal Microwaves

NASA Astrophysics Data System (ADS)

Goetz, J.; Pogorzalek, S.; Deppe, F.; Fedorov, K. G.; Eder, P.; Fischer, M.; Wulschner, F.; Xie, E.; Marx, A.; Gross, R.

2017-03-01

In experiments with superconducting quantum circuits, characterizing the photon statistics of propagating microwave fields is a fundamental task. We quantify the n2+n photon number variance of thermal microwave photons emitted from a blackbody radiator for mean photon numbers, 0.05 ≲n ≲1.5 . We probe the fields using either correlation measurements or a transmon qubit coupled to a microwave resonator. Our experiments provide a precise quantitative characterization of weak microwave states and information on the noise emitted by a Josephson parametric amplifier.

A Test of Superradiance in an FEL Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyce, R

We describe the design of an FEL Amplifier Test Experiment (FATE)1 to demonstrate the superradiant short bunch regime of a Free Electron Laser in the 1-3 {micro}m wavelength range starting from noise. The relevance to the LCLS X-ray FEL [1] proposal is discussed and numerical simulations are shown. It is numerically demonstrated for the first time with the 2-D code GINGER, that clean-up of noise in the superradiant regime occurs even at low power levels.

Gadolinium-based nanoparticles to improve the hadrontherapy performances.

PubMed

Porcel, Erika; Tillement, Olivier; Lux, François; Mowat, Pierre; Usami, Noriko; Kobayashi, Katsumi; Furusawa, Yoshiya; Le Sech, Claude; Li, Sha; Lacombe, Sandrine

2014-11-01

Nanomedicine is proposed as a novel strategy to improve the performance of radiotherapy. High-Z nanoparticles are known to enhance the effects of ionizing radiation. Recently, multimodal nanoparticles such as gadolinium-based nanoagents were proposed to amplify the effects of x-rays and g-rays and to improve MRI diagnosis. For tumors sited in sensitive tissues, childhood cases and radioresistant cancers, hadrontherapy is considered superior to x-rays and g-rays. Hadrontherapy, based on fast ion radiation, has the advantage of avoiding damage to the tissues behind the tumor; however, the damage caused in front of the tumor is its major limitation. Here, we demonstrate that multimodal gadolinium-based nanoparticles amplify cell death with fast ions used as radiation. Molecular scale experiments give insights into the mechanisms underlying the amplification of radiation effects. This proof-of-concept opens up novel perspectives for multimodal nanomedicine in hadrontherapy, ultimately reducing negative radiation effects in healthy tissues in front of the tumor. Gadolinium-chelating polysiloxane nanoparticles were previously reported to amplify the anti-tumor effects of x-rays and g-rays and to serve as MRI contrast agents. Fast ion radiation-based hadrontherapy avoids damage to the tissues behind the tumor, with a major limitation of tissue damage in front of the tumor. This study demonstrates a potential role for the above nanoagents in optimizing hadrontherapy with preventive effects in healthy tissue and amplified cell death in the tumor. Copyright © 2014 Elsevier Inc. All rights reserved.

Frequency range selection method of trans-impedance amplifier for high sensitivity lock-in amplifier used in the optical sensors

NASA Astrophysics Data System (ADS)

Park, Chang-In; Jeon, Su-Jin; Hong, Nam-Pyo; Choi, Young-Wan

2016-03-01

Lock-in amplifier (LIA) has been proposed as a detection technique for optical sensors because it can measure low signal in high noise level. LIA uses synchronous method, so the input signal frequency is locked to a reference frequency that is used to carry out the measurements. Generally, input signal frequency of LIA used in optical sensors is determined by modulation frequency of optical signal. It is important to understand the noise characteristics of the trans-impedance amplifier (TIA) to determine the modulation frequency. The TIA has a frequency range in which noise is minimized by the capacitance of photo diode (PD) and the passive component of TIA feedback network. When the modulation frequency is determined in this range, it is possible to design a robust system to noise. In this paper, we propose a method for the determination of optical signal modulation frequency selection by using the noise characteristics of TIA. Frequency response of noise in TIA is measured by spectrum analyzer and minimum noise region is confirmed. The LIA and TIA circuit have been designed as a hybrid circuit. The optical sensor is modeled by the laser diode (LD) and photo diode (PD) and the modulation frequency was used as the input to the signal generator. The experiments were performed to compare the signal to noise ratio (SNR) of the minimum noise region and the others. The results clearly show that the SNR is enhanced in the minimum noise region of TIA.

Is there a role for amplifiers in sexual selection?

PubMed

Gualla, Filippo; Cermelli, Paolo; Castellano, Sergio

2008-05-21

The amplifier hypothesis states that selection could favour the evolution of traits in signallers that improve the ability of receivers to extract honest information from other signals or cues. We provide a formal definition of amplifiers based on the receiver's mechanisms of signal perception and we present a game-theoretical model in which males advertise their quality and females use sequential-sampling tactics to choose among prospective mates. The main effect of an amplifier on the female mating strategy is to increase her mating threshold, making the female more selective as the effectiveness of the amplifier increases. The effects of the amplifier on male advertising strategy depends both on the context and on the types of the amplifier involved. We consider two different contexts for the evolution of amplifiers (when the effect of amplifiers is on signals and when it is on cues) and two types of amplifiers (the 'neutral amplifier', when it improves quality assessment without altering male attractiveness, and the 'attractive amplifier', when it improves both quality assessment and male attractiveness). The game-theoretical model provides two main results. First, neutral and attractive amplifiers represent, respectively, a conditional and an unconditional signalling strategy. In fact, at the equilibrium, neutral amplifiers are displayed only by males whose advertising level lays above the female acceptance threshold, whereas attractive amplifiers are displayed by all signalling males, independent of their quality. Second, amplifiers of signals increase the differences in advertising levels between amplifying and not-amplifying males, but they decrease the differences within each group, so that the system converges towards an 'all-or-nothing' signalling strategy. By applying concepts from information theory, we show that the increase in information transfer at the perception level due to the amplifier of signals is contrasted by a decrease in information transfer at the emitter level due to the increased stereotypy of male advertising strategy.

Auto-Zero Differential Amplifier

NASA Technical Reports Server (NTRS)

Quilligan, Gerard T. (Inventor); Aslam, Shahid (Inventor)

2017-01-01

An autozero amplifier may include a window comparator network to monitor an output offset of a differential amplifier. The autozero amplifier may also include an integrator to receive a signal from a latched window comparator network, and send an adjustment signal back to the differential amplifier to reduce an offset of the differential amplifier.

Design, construction and evaluation of a 12.2 GHz, 4.0 kW-CW high efficiency klystron amplifier. [for satellite-borne TV broadcast transmitters

NASA Technical Reports Server (NTRS)

Vishida, J. M.; Brodersen, L. K.

1974-01-01

An analytical and experimental program is described, for studying design techniques for optimizing the conversion efficiency of klystron amplifiers, and to utilize these techniques in the development and fabrication of an X-band 4 kW cw klystron, for use in satellite-borne television broadcast transmitters. The design is based on a technique for increasing the RF beam current by using the second harmonic space charge forces in the bunched beam. Experimental analysis was also made of a method to enhance circuit efficiency in the klystron cavities. The design incorporates a collector which is demountable from the tube to facilitate multistage depressed collector experiments employing an axisymmetric, electrostatic collector for linear beam microwave tubes.

Effect of air pollution and racism on ethnic differences in respiratory health among adolescents living in an urban environment☆

PubMed Central

Astell-Burt, Thomas; Maynard, Maria J.; Lenguerrand, Erik; Whitrow, Melissa J.; Molaodi, Oarabile R.; Harding, Seeromanie

2013-01-01

Recent studies suggest that stress can amplify the harm of air pollution. We examined whether experience of racism and exposure to particulate matter with an aerodynamic diameter of less than 2.5 µm and 10 µm (PM2.5 and PM10) had a synergistic influence on ethnic differences in asthma and lung function across adolescence. Analyses using multilevel models showed lower forced expiratory volume (FEV1), forced vital capacity (FVC) and lower rates of asthma among some ethnic minorities compared to Whites, but higher exposure to PM2.5, PM10 and racism. Racism appeared to amplify the relationship between asthma and air pollution for all ethnic groups, but did not explain ethnic differences in respiratory health. PMID:23933797

Ultra-low noise miniaturized neural amplifier with hardware averaging.

PubMed

Dweiri, Yazan M; Eggers, Thomas; McCallum, Grant; Durand, Dominique M

2015-08-01

Peripheral nerves carry neural signals that could be used to control hybrid bionic systems. Cuff electrodes provide a robust and stable interface but the recorded signal amplitude is small (<3 μVrms 700 Hz-7 kHz), thereby requiring a baseline noise of less than 1 μVrms for a useful signal-to-noise ratio (SNR). Flat interface nerve electrode (FINE) contacts alone generate thermal noise of at least 0.5 μVrms therefore the amplifier should add as little noise as possible. Since mainstream neural amplifiers have a baseline noise of 2 μVrms or higher, novel designs are required. Here we apply the concept of hardware averaging to nerve recordings obtained with cuff electrodes. An optimization procedure is developed to minimize noise and power simultaneously. The novel design was based on existing neural amplifiers (Intan Technologies, LLC) and is validated with signals obtained from the FINE in chronic dog experiments. We showed that hardware averaging leads to a reduction in the total recording noise by a factor of 1/√N or less depending on the source resistance. Chronic recording of physiological activity with FINE using the presented design showed significant improvement on the recorded baseline noise with at least two parallel operation transconductance amplifiers leading to a 46.1% reduction at N = 8. The functionality of these recordings was quantified by the SNR improvement and shown to be significant for N = 3 or more. The present design was shown to be capable of generating <1.5 μVrms total recording baseline noise when connected to a FINE placed on the sciatic nerve of an awake animal. An algorithm was introduced to find the value of N that can minimize both the power consumption and the noise in order to design a miniaturized ultralow-noise neural amplifier. These results demonstrate the efficacy of hardware averaging on noise improvement for neural recording with cuff electrodes, and can accommodate the presence of high source impedances that are associated with the miniaturized contacts and the high channel count in electrode arrays. This technique can be adopted for other applications where miniaturized and implantable multichannel acquisition systems with ultra-low noise and low power are required.

DESIGN OF MEDICAL RADIOMETER FRONT-END FOR IMPROVED PERFORMANCE

PubMed Central

Klemetsen, Ø.; Birkelund, Y.; Jacobsen, S. K.; Maccarini, P. F.; Stauffer, P. R.

2011-01-01

We have investigated the possibility of building a singleband Dicke radiometer that is inexpensive, small-sized, stable, highly sensitive, and which consists of readily available microwave components. The selected frequency band is at 3.25–3.75 GHz which provides a reasonable compromise between spatial resolution (antenna size) and sensing depth for radiometry applications in lossy tissue. Foreseen applications of the instrument are non-invasive temperature monitoring for breast cancer detection and temperature monitoring during heating. We have found off-the-shelf microwave components that are sufficiently small (< 5 mm × 5 mm) and which offer satisfactory overall sensitivity. Two different Dicke radiometers have been realized: one is a conventional design with the Dicke switch at the front-end to select either the antenna or noise reference channels for amplification. The second design places a matched pair of low noise amplifiers in front of the Dicke switch to reduce system noise figure. Numerical simulations were performed to test the design concepts before building prototype PCB front-end layouts of the radiometer. Both designs provide an overall power gain of approximately 50 dB over a 500 MHz bandwidth centered at 3.5 GHz. No stability problems were observed despite using triple-cascaded amplifier configurations to boost the thermal signals. The prototypes were tested for sensitivity after calibration in two different water baths. Experiments showed superior sensitivity (36% higher) when implementing the low noise amplifier before the Dicke switch (close to the antenna) compared to the other design with the Dicke switch in front. Radiometer performance was also tested in a multilayered phantom during alternating heating and radiometric reading. Empirical tests showed that for the configuration with Dicke switch first, the switch had to be locked in the reference position during application of microwave heating to avoid damage to the active components (amplifiers and power meter). For the configuration with a low noise amplifier up front, damage would occur to the active components of the radiometer if used in presence of the microwave heating antenna. Nevertheless, this design showed significantly improved sensitivity of measured temperatures and merits further investigation to determine methods of protecting the radiometer for amplifier first front ends. PMID:21779411

Compact Ultraintense Femtosecond Laser via Raman Amplifier and Compressor in Plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suckewer, Szymon

2016-03-01

The main objective of this project was to conduct experimental and theoretical research to find conditions leading to higher, than previously obtained efficiency η of transfer the pump energy into the short seed beam in plasma of Stimulated Raman Back-Scattering (SRBS). We have demonstrated very large amplification and compression in our earlier SRBS plasma. However, the efficiency η was much too low to reach very high intensity of the output beam in the focal spot. Recently, by solving a very difficult technical SRBS’ problem, namely, the creation of very reproducible and much larger diameter plasma channels than in our earliermore » research, we propose a new approach to obtain higher efficiency η. The crucial new result was a very reproducible, low noise amplified seed in the larger diameter of the plasma channel leading to the higher efficiency. Using this new setup and very encouraging results about increase efficiency continuing this approach in the future the efficiency is expect to reach the range of η ≈15 - 20 % required to develop practical SRBS plasma laser. Intellectual Merit: The model for the present project was created by our earlier SRBS experiments. The main objective of those experiments was to amplify and compress the seed pulses in a plasma . The experiments demonstrated an unprecedented large pulse intensity amplification of 20,000 in system of 2-passes in ~2mm long plasma, and the seed pulse compression from 550fsec down to ~50fsec. The pump and seed beams in the present project have diameters of ~0.2–0.25mm each, propagating in ~0.35 - 0.45mm diameter and ~2-2.5mm long plasma channels (optimal length for our SRBS experiment) with input pump and seed intensities of 2x1014 and 3x1013 W/cm2, respectively. Such an SRBS system design was “prescribed” by computer simulations, which predict elimination of the SRBS “ saturation” for a such relatively short plasma channel. Plasma channels has been created by combining shorter (200psec) and longer (5nsec) laser pulses using an axicon lens for shorter pulse and spherical lens for longer pulse, a unique procedure we have developed for SRBS experiments.« less

Gain and noise figure enhancement of Er+3/Yb+3 co-doped fiber/Raman hybrid amplifier

NASA Astrophysics Data System (ADS)

Mahran, O.

2016-02-01

An Er/Yb co-doped fiber/Raman hybrid amplifier (HA) is proposed and studied theoretically and analytically to improve the gain and noise figure of optical amplifiers. The calculations are performed under a uniform dopant and steady-state conditions. The initial energy transfer efficiency for Er/Yb co-doped fiber amplifier (EYDFA) is introduced, while the amplified spontaneous emission (ASE) is neglected. The glass fiber used for both Er/Yb and Raman amplifiers is phosphate. Different pump powers are used for both EYDFA and RA with 1 μW input signal power, 1 m length of Er/Yb amplifier and 25 km length of Raman amplifier (RA). The proposed model is validated for Er/Yb co-doped amplifier and Raman amplifier separately by comparing the calculating results with the experimental data. A high gain and low noise figure at 200 mW Raman pump power and 500 mW Er/Yb pump power are obtained for the proposed HA as compared with the experimental results of EYDFA, Raman amplifier and the EDFA/Raman hybrid amplifier.

Effects of Nicotine on Olfactogustatory Incentives: Preference, Palatability, and Operant Choice Tests

PubMed Central

2013-01-01

Introduction: The use of additives in tobacco may capitalize on the incentive motivational properties of tastes and scents such as mint (menthol), vanilla, and strawberry. These incentives are intended to increase tobacco experimentation, but their salience may also be enhanced by the incentive amplifying effects of nicotine (NIC). The goal of the present studies was to investigate the potential interaction between the incentive amplifying effects of NIC and gustatory incentives. Methods: One of two discriminable tastes (grape or cherry Kool-Aid®; 0.05% wt/vol; unsweetened) was paired with sucrose (20% wt/vol; conditioned stimulus [CS+]) in deionized water, whereas the other taste (CS−) was presented in deionized water. Experiment 1 investigated the effects of NIC pretreatment on preference for the CS+ versus CS− in 2-bottle choice tests. Experiment 2 investigated the effects of NIC on palatability of the CS+ and CS− using orofacial taste reactions. Experiment 3 investigated the effects of NIC on reinforcement by the CS+ and CS− using a concurrent choice operant task. Results: NIC pretreatment robustly increased operant responding for the CS+ but did not alter responding for the CS− in the operant choice task (Experiment 3). However, NIC pretreatment did not alter intake or palatability of the CS+ or CS− (Experiments 1 and 2). Conclusions: NIC increases the reinforcing effects of gustatory incentive stimuli, even though these stimuli were not paired with NIC administration. The findings suggest that adding taste incentives to tobacco products may increase the attractiveness of these products to consumers and the probability of repeated use. PMID:23430737

The front-end electronics of the LSPE-SWIPE experiment

NASA Astrophysics Data System (ADS)

Fontanelli, F.; Biasotti, M.; Bevilacqua, A.; Siccardi, F.

2016-07-01

The SWIPE detector of the Ballon Borne Mission LSPE (see e.g. the contribution of P. de Bernardis et al. in this conference) intends to measure the primordial 'B-mode' polarization of the Cosmic Microwave Background (CMB). For this scope microwave telescopes need sensitive cryogenic bolometers with an overall equivalent noise temperature in the nK range. The detector is a spiderweb bolometer based on transition edge sensor and followed by a SQUID to perform the signal readout. This contribution will concentrate on the design, description and first tests on the front-end electronics which processes the squid output (and controls it). The squid output is first amplified by a very low noise preamplifier based on a discrete JFET input differential architecture followed by a low noise CMOS operational amplifier. Equivalent input noise density is 0.6 nV/Hz and bandwidth extends up to at least 2 MHz. Both devices (JFET and CMOS amplifier) have been tested at liquid nitrogen. The second part of the contribution will discuss design and results of the control electronics, both the flux locked loop for the squid and the slow control chain to monitor and set up the system will be reviewed.

High Efficiency End-Pumped Ho:Tm:YLF Disk Amplifier

NASA Technical Reports Server (NTRS)

Yu, Jirong; Singh, Upendra N.; Petros, Mulugeta; Axenson, Theresa J.; Barnes, Norman P.

1999-01-01

Space based coherent lidar for global wind measurement requires an all solid state laser system with high energy, high efficiency and narrow linewidth that operates in the eye safe region. A Q-switched, diode pumped Ho:Tm:YLF 2 micrometer laser with output energy of as much as 125 mJ at 6 Hz with an optical-to-optical efficiency of 3% has been reported. Single frequency operation of the laser was achieved by injection seeding. The design of this laser is being incorporated into NASA's SPARCLE (SPAce Readiness Coherent Lidar Experiment) wind lidar mission. Laser output energy ranging from 500 mJ to 2 J is required for an operational space coherent lidar. We previously developed a high energy Ho:Tm:YLF master oscillator and side pumped power amplifier system and demonstrated a 600-mJ single frequency pulse at a repetition rate of 10 Hz. Although the output energy is high, the optical-to-optical efficiency is only about 2%. Designing a high energy, highly efficient, conductively cooled 2-micrometer laser remains a challenge. In this paper, the preliminary result of an end-pumped amplifier that has a potential to provide a factor 3 of improvement in the system efficiency is reported.

Josephson Parametric Amplifer Based on a Cavity-Embedded Cooper Pair Transistor

NASA Astrophysics Data System (ADS)

Li, Juliang; Rimberg, A. J.

In this experiment a cavity-embedded Cooper-pair transistor (cCPT) is used as a Josephson parametric amplifier. The cCPT consists of a Cooper pair transistor placed at the voltage antinode of a 5.7 GHz shorted quarter-wave resonator so that the CPT provides a galvanic connection between the cavity's central conductor and ground plane, which forms a SQUID loop. Both the flux threading the loop as well as the gate charge can be modulated, and each can provide the parametric pumping. The reflected signal from the cCPT is further amplified by both SLUG and HEMT amplifiers for characterizing the parametric amplification. A first application of the parametric amplification is to improve the charge sensitivity of a single electron charge detector. This can be done either by pumping on a side band or by shifting the charge state of the cCPT near a bifurcation point. Stimulated emission has been also observed when the cCPT is pumped at twice the resonant frequency in the absence of an input signal. This could allow investigation of the dynamic Casimir effect as well as generation of non-classical photon states. Supported by Grants ARO W911NF-13-10377 and NSF DMR 1507400.

A novel pseudo resistor structure for biomedical front-end amplifiers.

PubMed

Yu-Chieh Huang; Tzu-Sen Yang; Shun-Hsi Hsu; Xin-Zhuang Chen; Jin-Chern Chiou

2015-08-01

This study proposes a novel pseudo resistor structure with a tunable DC bias voltage for biomedical front-end amplifiers (FEAs). In the proposed FEA, the high-pass filter composed of differential difference amplifier and a pseudo resistor is implemented. The FEA is manufactured by using a standard TSMC 0.35 μm CMOS process. In this study, three types FEAs included three different pseudo resistor are simulated, fabricated and measured for comparison and electrocorticography (ECoG) measurement, and all the results show the proposed pseudo resistor is superior to other two types in bandwidth. In chip implementation, the lower and upper cutoff frequencies of the high-pass filter with the proposed pseudo resistor are 0.15 Hz and 4.98 KHz, respectively. It also demonstrates lower total harmonic distortion performance of -58 dB at 1 kHz and higher stability with wide supply range (1.8 V and 3.3 V) and control voltage range (0.9 V and 1.65 V) than others. Moreover, the FEA with the proposed pseudo successfully recorded spike-and-wave discharges of ECoG signal in in vivo experiment on rat with pentylenetetrazol-induced seizures.

Induction magnetometer using a high-Tc superconductor coil

NASA Astrophysics Data System (ADS)

Sasada, Ichiro

2010-05-01

An induction magnetometer consisting of a search coil and an inverting operational amplifier is simple in structure and in signal transferring mechanism from the magnetic field input to the voltage output. Because this magnetometer is based on Faraday's law of induction, it has a lower cutoff frequency r/(2πL), where r is the resistance of the coil and L is its inductance. An attempt has been made to lower the cutoff frequency of the induction magnetometer by using a high-Tc superconductor coil. With a pancake coil (inner diameter ≈18 cm and outer diameter ≈23 cm, 92 turns, 3.23 mH) made of a Bismuth strontium calcium copper oxide (BSCCO) superconductor tape of 5 mm in width and 0.23 mm in thickness, the cutoff frequency achieved was 1.7 Hz which is much lower than that obtained with a bulky copper search coil which is typically in the range of 10-20 Hz. In the experiment, an inverting amplifier was made with a complementary metal-oxide semiconductor operational amplifier and was immersed in liquid nitrogen together with a BSCCO high-Tc superconducting coil. Discussion is made on the resolution of the induction magnetometer using a high-Tc superconductor search coil.

Direct solar-pumped iodine laser amplifier

NASA Technical Reports Server (NTRS)

Han, Kwang S.; Hwang, In Heon

1990-01-01

The optimum conditions of a solar pumped iodine laser are found in this research for the case of a continuous wave operation and a pulsed operation. The optimum product of the pressure(p) inside the laser tube and the tube diameter(d) was pd=40 approx. 50 torr-cm on the contrary to the case of a high intensity flashlamp pumped iodine laser where the optimum value of the product is known to be pd=150 torr-cm. The pressure-diameter product is less than 1/3 of that of the high power iodine laser. During the research period, various laser materials were also studied for solar pumping. Among the laser materials, Nd:YAG is found to have the lowest laser threshold pumping intensity of about 200 solar constant. The Rhodamine 6G was also tested as the solar pumped laser material. The threshold pumping power was measured to be about 20,000 solar constant. The amplification experiment for a continuously pumped iodine laser amplifier was performed using Vortek solar simulator and the amplification factors were measured for single pass amplification and triple pass amplification of the 15 cm long amplifier tube. The amplification of 5 was obtained for the triple pass amplification.

Multi-pass amplifier architecture for high power laser systems

DOEpatents

Manes, Kenneth R; Spaeth, Mary L; Erlandson, Alvin C

2014-04-01

A main amplifier system includes a first reflector operable to receive input light through a first aperture and direct the input light along an optical path. The input light is characterized by a first polarization. The main amplifier system also includes a first polarizer operable to reflect light characterized by the first polarization state. The main amplifier system further includes a first and second set of amplifier modules. Each of the first and second set of amplifier modules includes an entrance window, a quarter wave plate, a plurality of amplifier slablets arrayed substantially parallel to each other, and an exit window. The main amplifier system additionally includes a set of mirrors operable to reflect light exiting the first set of amplifier modules to enter the second set of amplifier modules and a second polarizer operable to reflect light characterized by a second polarization state.

Application of Multi-Input Multi-Output Feedback Control for F-16 Ventral Fin Buffet Alleviation Using Piezoelectric Actuators

DTIC Science & Technology

2012-03-22

Power Amplifier (7). A power amplifier was required to drive the actuators. For this research a Trek , Inc. Model PZD 700 Dual Channel Amplifier was used...while the flight test amplifier was being built. The Trek amplifier was capable of amplifying 32 Figure 3.19: dSpace MicroAutoBox II Digital...averaging of 25% was used to reduce the errors caused by noise but still maintain accuracy. For the laboratory Trek amplifier, a 100 millivolt input

Using Green and Red Fluorescent Proteins to Teach Protein Expression, Purification, and Crystallization

ERIC Educational Resources Information Center

Wu, Yifeng; Zhou, Yangbin; Song, Jiaping; Hu, Xiaojian; Ding, Yu; Zhang, Zhihong

2008-01-01

We have designed a laboratory curriculum using the green and red fluorescent proteins (GFP and RFP) to visualize the cloning, expression, chromatography purification, crystallization, and protease-cleavage experiments of protein science. The EGFP and DsRed monomer (mDsRed)-coding sequences were amplified by PCR and cloned into pMAL (MBP-EGFP) or…

Effects of Loud and Amplified Speech on Sentence and Word Intelligibility in Parkinson Disease

ERIC Educational Resources Information Center

Neel, Amy T.

2009-01-01

Purpose: In the two experiments in this study, the author examined the effects of increased vocal effort (loud speech) and amplification on sentence and word intelligibility in speakers with Parkinson disease (PD). Methods: Five talkers with PD produced sentences and words at habitual levels of effort and using loud speech techniques. Amplified…

Evaluating Students' Perception of Group Work for Mobile Application Development Learning, Productivity, Enjoyment and Confidence in Quality

ERIC Educational Resources Information Center

Powell, Loreen M.; Wimmer, Hayden

2016-01-01

Teaching programming and mobile application development concepts can be challenging for instructors; however, teaching an interdisciplinary class with varied skill levels amplifies this challenge. To encompass a broad range of students, many instructors have sought to improve their lessons and methods by experimenting with group/team programming.…

College Experiences for Students with Autism Spectrum Disorder: Personal Identity, Public Disclosure, and Institutional Support

ERIC Educational Resources Information Center

Cox, Bradley E.; Thompson, Kerry; Anderson, Amelia; Mintz, Amanda; Locks, Taylor; Morgan, Lindee; Edelstein, Jeffrey; Wolz, Abigail

2017-01-01

Individuals with autism spectrum disorder (ASD) are completing high school with reasonable expectations for postsecondary success. College educators are likely ill prepared to provide appropriate support for these students. Based on personal interviews with a diverse group of students with autism, this study (a) amplifies these students' voices,…

Skylab lessons learned as applicable to a large space station, 1967-1974. Ph.D. Thesis - Catholic Univ. of Am.

NASA Technical Reports Server (NTRS)

Schneider, W. C.

1976-01-01

This report records some of the lessons learned during Skylab development. The approach taken is to list lessons which could have wide application in the development of a large space station. The lessons are amplified and explained in light of the background and experiences of the Skylab development.

Amplifying Staff Development through Film: The Case of a University Staff Visit to a Sixth Form College

ERIC Educational Resources Information Center

Prowse, Alicia; Sweasey, Penny; Delbridge, Rachel

2017-01-01

Purpose: The literature on student transition to university commonly investigates student expectations, perceptions and experiences and rarely focusses on university academic staff viewpoints. The purpose of this paper is to explore the staff development potential of a filmed visit of university academic staff to a sixth form college.…

Towards a Narrowband Photonic Sigma-Delta Digital Antenna

DTIC Science & Technology

2012-02-01

High Speed Photodiode/ Amplifier 26 G no amplifier 50 k transimpedance amplifier N/A 12 ps rise time 50 Ω output impedance HP 8447A Amplifier ......Response for the optical amplifier as a function of input drive current

Low noise tuned amplifier

NASA Technical Reports Server (NTRS)

Kleinberg, L. L. (Inventor)

1984-01-01

A bandpass amplifier employing a field effect transistor amplifier first stage is described with a resistive load either a.c. or directly coupled to the non-inverting input of an operational amplifier second stage which is loaded in a Wien Bridge configuration. The bandpass amplifier may be operated with a signal injected into the gate terminal of the field effect transistor and the signal output taken from the output terminal of the operational amplifier. The operational amplifier stage appears as an inductive reactance, capacitive reactance and negative resistance at the non-inverting input of the operational amplifier, all of which appear in parallel with the resistive load of the field effect transistor.

Matched wideband low-noise amplifiers for radio astronomy.

PubMed

Weinreb, S; Bardin, J; Mani, H; Jones, G

2009-04-01

Two packaged low noise amplifiers for the 0.3-4 GHz frequency range are described. The amplifiers can be operated at temperatures of 300-4 K and achieve noise temperatures in the 5 K range (<0.1 dB noise figure) at 15 K physical temperature. One amplifier utilizes commercially available, plastic-packaged SiGe transistors for first and second stages; the second amplifier is identical except it utilizes an experimental chip transistor as the first stage. Both amplifiers use resistive feedback to provide input reflection coefficient S11<-10 dB over a decade bandwidth with gain over 30 dB. The amplifiers can be used as rf amplifiers in very low noise radio astronomy systems or as i.f. amplifiers following superconducting mixers operating in the millimeter and submillimeter frequency range.

Power-Amplifier Module for 145 to 165 GHz

NASA Technical Reports Server (NTRS)

Samoska, Lorene; Peralta, Alejandro

2007-01-01

A power-amplifier module that operates in the frequency range of 145 to 165 GHz has been designed and constructed as a combination of (1) a previously developed monolithic microwave integrated circuit (MMIC) power amplifier and (2) a waveguide module. The amplifier chip was needed for driving a high-electron-mobility-transistor (HEMT) frequency doubler. While it was feasible to connect the amplifier and frequency-doubler chips by use of wire bonds, it was found to be much more convenient to test the amplifier and doubler chips separately. To facilitate separate testing, it was decided to package the amplifier and doubler chips in separate waveguide modules. Figure 1 shows the resulting amplifier module. The amplifier chip was described in "MMIC HEMT Power Amplifier for 140 to 170 GHz" (NPO-30127), NASA Tech Briefs, Vol. 27, No. 11, (November 2003), page 49. To recapitulate: This is a three-stage MMIC power amplifier that utilizes HEMTs as gain elements. The amplifier was originally designed to operate in the frequency range of 140 to 170 GHz. The waveguide module is based on a previously developed lower frequency module, redesigned to support operation in the frequency range of 140 to 220 GHz. Figure 2 presents results of one of several tests of the amplifier module - measurements of output power and gain as functions of input power at an output frequency of 150 GHz. Such an amplifier module has many applications to test equipment for power sources above 100 GHz.

System Modeling of kJ-class Petawatt Lasers at LLNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shverdin, M Y; Rushford, M; Henesian, M A

2010-04-14

Advanced Radiographic Capability (ARC) project at the National Ignition Facility (NIF) is designed to produce energetic, ultrafast x-rays in the range of 70-100 keV for backlighting NIF targets. The chirped pulse amplification (CPA) laser system will deliver kilo-Joule pulses at an adjustable pulse duration from 1 ps to 50 ps. System complexity requires sophisticated simulation and modeling tools for design, performance prediction, and comprehension of experimental results. We provide a brief overview of ARC, present our main modeling tools, and describe important performance predictions. The laser system (Fig. 1) consists of an all-fiber front end, including chirped-fiber Bragg grating (CFBG)more » stretchers. The beam after the final fiber amplifier is split into two apertures and spatially shaped. The split beam first seeds a regenerative amplifier and is then amplified in a multi-pass Nd:glass amplifier. Next, the preamplified chirped pulse is split in time into four identical replicas and injected into one NIF Quad. At the output of the NIF beamline, each of the eight amplified pulses is compressed in an individual, folded, four-grating compressor. Compressor grating pairs have slightly different groove densities to enable compact folding geometry and eliminate adjacent beam cross-talk. Pulse duration is adjustable with a small, rack-mounted compressor in the front-end. We use non-sequential ray-tracing software, FRED for design and layout of the optical system. Currently, our FRED model includes all of the optical components from the output of the fiber front end to the target center (Fig. 2). CAD designed opto-mechanical components are imported into our FRED model to provide a complete system description. In addition to incoherent ray tracing and scattering analysis, FRED uses Gaussian beam decomposition to model coherent beam propagation. Neglecting nonlinear effects, we can obtain a nearly complete frequency domain description of the ARC beam at different stages in the system. We employ 3D Fourier based propagation codes: MIRO, Virtual Beamline (VBL), and PROP for time-domain pulse analysis. These codes simulate nonlinear effects, calculate near and far field beam profiles, and account for amplifier gain. Verification of correct system set-up is a major difficulty to using these codes. VBL and PROP predictions have been extensively benchmarked to NIF experiments, and the verified descriptions of specific NIF beamlines are used for ARC. MIRO has the added capability of treating bandwidth specific effects of CPA. A sample MIRO model of the NIF beamline is shown in Fig. 3. MIRO models are benchmarked to VBL and PROP in the narrow bandwidth mode. Developing a variety of simulation tools allows us to cross-check predictions of different models and gain confidence in their fidelity. Preliminary experiments, currently in progress, are allowing us to validate and refine our models, and help guide future experimental campaigns.« less

Industrial universal electrometer

DOEpatents

Cordaro, Joseph V [Martinez, GA; Wood, Michael B [Aiken, SC

2012-07-03

An electrometer for use in measuring current is provided. The electrometer includes an enclosure capable of containing various components of the electrometer. A pre-amplifier is present and is one of the components of the electrometer. The pre-amplifier is contained by the enclosure. The pre-amplifier has a pre-amplifier enclosure that contains the pre-amplifier and provides radio frequency shielding and magnetic shielding to the pre-amplifier.

Limit circuit prevents overdriving of operational amplifier

NASA Technical Reports Server (NTRS)

Openshaw, F. L.

1967-01-01

Cutoff-type high gain amplifier coupled by a diode prevents overdriving of operational amplifier. An amplified feedback signal offsets the excess input signal that tends to cause the amplifier to exceed its preset limit. The output is, therfore, held to the set clamp level.

Method to amplify variable sequences without imposing primer sequences

DOEpatents

Bradbury, Andrew M.; Zeytun, Ahmet

2006-11-14

The present invention provides methods of amplifying target sequences without including regions flanking the target sequence in the amplified product or imposing amplification primer sequences on the amplified product. Also provided are methods of preparing a library from such amplified target sequences.

21 CFR 882.1835 - Physiological signal amplifier.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Physiological signal amplifier. 882.1835 Section... signal amplifier. (a) Identification. A physiological signal amplifier is a general purpose device used to electrically amplify signals derived from various physiological sources (e.g., the...

21 CFR 882.1835 - Physiological signal amplifier.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Physiological signal amplifier. 882.1835 Section... signal amplifier. (a) Identification. A physiological signal amplifier is a general purpose device used to electrically amplify signals derived from various physiological sources (e.g., the...

Cross-differential amplifier

NASA Technical Reports Server (NTRS)

Hajimiri, Seyed-Ali (Inventor); Kee, Scott D. (Inventor); Aoki, Ichiro (Inventor)

2010-01-01

A cross-differential amplifier is provided. The cross-differential amplifier includes an inductor connected to a direct current power source at a first terminal. A first and second switch, such as transistors, are connected to the inductor at a second terminal. A first and second amplifier are connected at their supply terminals to the first and second switch. The first and second switches are operated to commutate the inductor between the amplifiers so as to provide an amplified signal while limiting the ripple voltage on the inductor and thus limiting the maximum voltage imposed across the amplifiers and switches.

Cross-differential amplifier

NASA Technical Reports Server (NTRS)

Hajimiri, Seyed-Ali (Inventor); Kee, Scott D. (Inventor); Aoki, Ichiro (Inventor)

2011-01-01

A cross-differential amplifier is provided. The cross-differential amplifier includes an inductor connected to a direct current power source at a first terminal. A first and second switch, such as transistors, are connected to the inductor at a second terminal. A first and second amplifier are connected at their supply terminals to the first and second switch. The first and second switches are operated to commutate the inductor between the amplifiers so as to provide an amplified signal while limiting the ripple voltage on the inductor and thus limiting the maximum voltage imposed across the amplifiers and switches.

Hybrid matrix amplifier

DOEpatents

Martens, J.S.; Hietala, V.M.; Plut, T.A.

1995-01-03

The present invention comprises a novel matrix amplifier. The matrix amplifier includes an active superconducting power divider (ASPD) having N output ports; N distributed amplifiers each operatively connected to one of the N output ports of the ASPD; and a power combiner having N input ports each operatively connected to one of the N distributed amplifiers. The distributed amplifier can included M stages of amplification by cascading superconducting active devices. The power combiner can include N active elements. The resulting (N[times]M) matrix amplifier can produce signals of high output power, large bandwidth, and low noise. 6 figures.

Cross-differential amplifier

NASA Technical Reports Server (NTRS)

Aoki, Ichiro (Inventor); Hajimiri, Seyed-Ali (Inventor); Kee, Scott D. (Inventor)

2013-01-01

A cross-differential amplifier is provided. The cross-differential amplifier includes an inductor connected to a direct current power source at a first terminal. A first and second switch, such as transistors, are connected to the inductor at a second terminal. A first and second amplifier are connected at their supply terminals to the first and second switch. The first and second switches are operated to commutate the inductor between the amplifiers so as to provide an amplified signal while limiting the ripple voltage on the inductor and thus limiting the maximum voltage imposed across the amplifiers and switches.

Hybrid matrix amplifier

DOEpatents

Martens, Jon S.; Hietala, Vincent M.; Plut, Thomas A.

1995-01-01

The present invention comprises a novel matrix amplifier. The matrix amplifier includes an active superconducting power divider (ASPD) having N output ports; N distributed amplifiers each operatively connected to one of the N output ports of the ASPD; and a power combiner having N input ports each operatively connected to one of the N distributed amplifiers. The distributed amplifier can included M stages of amplification by cascading superconducting active devices. The power combiner can include N active elements. The resulting (N.times.M) matrix amplifier can produce signals of high output power, large bandwidth, and low noise.

Cross-differential amplifier

NASA Technical Reports Server (NTRS)

Hajimiri, Seyed-Ali (Inventor); Kee, Scott D. (Inventor); Aoki, Ichiro (Inventor)

2008-01-01

A cross-differential amplifier is provided. The cross-differential amplifier includes an inductor connected to a direct current power source at a first terminal. A first and second switch, such as transistors, are connected to the inductor at a second terminal. A first and second amplifier are connected at their supply terminals to the first and second switch. The first and second switches are operated to commutate the inductor between the amplifiers so as to provide an amplified signal while limiting the ripple voltage on the inductor and thus limiting the maximum voltage imposed across the amplifiers and switches.

A 1-W, 30-ghz, CPW Amplifier for ACTS Small Terminal Uplink

NASA Technical Reports Server (NTRS)

Taub, Susan R.; Simons, Rainee N.

1992-01-01

The progress is described of the development of a 1 W, 30 GHz, coplanar waveguide (CPW) amplifier for the Advanced Communication Technology Satellite (ACTS)Small Terminal Uplink. The amplifier is based on Texas Instruments' monolithic microwave integrated circuit (MMIC) amplifiers; a three stage, low power amplifier, and a single stage, high power amplifier. The amplifiers have a power output of 190 mW and 0.710 W, gain of 23 and 4.2 dB, and efficiencies of 30.2 and 24 percent for the three stage and one stage amplifiers, respectively. The chips are to be combined via a CPW power divider/combiner circuit to yield the desired 1 W of output power.

Amplified Head Rotation in Virtual Reality and the Effects on 3D Search, Training Transfer, and Spatial Orientation.

PubMed

Ragan, Eric D; Scerbo, Siroberto; Bacim, Felipe; Bowman, Doug A

2017-08-01

Many types of virtual reality (VR) systems allow users to use natural, physical head movements to view a 3D environment. In some situations, such as when using systems that lack a fully surrounding display or when opting for convenient low-effort interaction, view control can be enabled through a combination of physical and virtual turns to view the environment, but the reduced realism could potentially interfere with the ability to maintain spatial orientation. One solution to this problem is to amplify head rotations such that smaller physical turns are mapped to larger virtual turns, allowing trainees to view the entire surrounding environment with small head movements. This solution is attractive because it allows semi-natural physical view control rather than requiring complete physical rotations or a fully-surrounding display. However, the effects of amplified head rotations on spatial orientation and many practical tasks are not well understood. In this paper, we present an experiment that evaluates the influence of amplified head rotation on 3D search, spatial orientation, and cybersickness. In the study, we varied the amount of amplification and also varied the type of display used (head-mounted display or surround-screen CAVE) for the VR search task. By evaluating participants first with amplification and then without, we were also able to study training transfer effects. The findings demonstrate the feasibility of using amplified head rotation to view 360 degrees of virtual space, but noticeable problems were identified when using high amplification with a head-mounted display. In addition, participants were able to more easily maintain a sense of spatial orientation when using the CAVE version of the application, which suggests that visibility of the user's body and awareness of the CAVE's physical environment may have contributed to the ability to use the amplification technique while keeping track of orientation.

Towards a THz backward wave amplifier in European OPTHER project

NASA Astrophysics Data System (ADS)

Dispenza, M.; Brunetti, F.; Cojocaru, C.-S.; de Rossi, A.; Di Carlo, A.; Dolfi, D.; Durand, A.; Fiorello, A. M.; Gohier, A.; Guiset, P.; Kotiranta, M.; Krozer, V.; Legagneux, P.; Marchesin, R.; Megtert, S.; Bouamrane, F.; Mineo, M.; Paoloni, C.; Pham, K.; Schnell, J. P.; Secchi, A.; Tamburri, E.; Terranova, M. L.; Ulisse, G.; Zhurbenko, V.

2010-10-01

Within the EC funded international project OPTHER (OPtically Driven TeraHertz AmplifiERs) a considerable technological effort is being undertaken, in terms of technological development, THz device design and integration. The ultimate goal is to develop a miniaturised THz amplifier based on vacuum-tube principles The main target specifications of the OPTHER amplifier are the following: - Operating frequency: in the band 0.3 to 2 THz - Output power: > 10 mW ( 10 dBm ) - Gain: 10 to 20 dB. The project is in the middle of its duration. Design and simulations have shown that these targets can be met with a proper device configuration and careful optimization of the different parts of the amplifier. Two parallel schemes will be employed for amplifier realisation: THz Drive Signal Amplifier and Optically Modulated Beam THz Amplifier.

Improved Grid-Array Millimeter-Wave Amplifier

NASA Technical Reports Server (NTRS)

Rosenberg, James J.; Rutledge, David B.; Smith, R. Peter; Weikle, Robert

1993-01-01

Improved grid-array amplifiers operating at millimeter and submillimeter wavelengths developed for use in communications and radar. Feedback suppressed by making input polarizations orthogonal to output polarizations. Amplifier made to oscillate by introducing some feedback. Several grid-array amplifiers concatenated to form high-gain beam-amplifying unit.

Nearly noiseless amplification of microwave signals with a Josephson parametric amplifier

NASA Astrophysics Data System (ADS)

Castellanos-Beltran, Manuel

2009-03-01

A degenerate parametric amplifier transforms an incident coherent state by amplifying one of its quadrature components while deamplifying the other. This transformation, when performed by an ideal parametric amplifier, is completely deterministic and reversible; therefore the amplifier in principle can be noiseless. We attempt to realize a noiseless amplifier of this type at microwave frequencies with a Josephson parametric amplifier (JPA). To this end, we have built a superconducting microwave cavity containing many dc-SQUIDs. This arrangement creates a non-linear medium in a cavity and it is closely analogous to an optical parametric amplifier. In my talk, I will describe the current performance of this circuit, where I show I can amplify signals with less added noise than a quantum-limited amplifier that amplifies both quadratures. In addition, the JPA also squeezes the electromagnetic vacuum fluctuations by 10 dB. Finally, I will discuss our effort to put two such amplifiers in series in order to undo the first stage of squeezing with a second stage of amplification, demonstrating that the amplification process is truly reversible.[4pt] M. A. Castellanos-Beltran, K. D. Irwin, G. C. Hilton, L. R. Vale and K. W. Lehnert, Nature Physics, published on line, http://dx.doi.org/10.1038/nphys1090 (2008).

High frequency inductive lamp and power oscillator

DOEpatents

Kirkpatrick, Douglas A.; Gitsevich, Aleksandr

2005-09-27

An oscillator includes an amplifier having an input and an output, a feedback network connected between the input of the amplifier and the output of the amplifier, the feedback network being configured to provide suitable positive feedback from the output of the amplifier to the input of the amplifier to initiate and sustain an oscillating condition, and a tuning circuit connected to the input of the amplifier, wherein the tuning circuit is continuously variable and consists of solid state electrical components with no mechanically adjustable devices including a pair of diodes connected to each other at their respective cathodes with a control voltage connected at the junction of the diodes. Another oscillator includes an amplifier having an input and an output, a feedback network connected between the input of the amplifier and the output of the amplifier, the feedback network being configured to provide suitable positive feedback from the output of the amplifier to the input of the amplifier to initiate and sustain an oscillating condition, and transmission lines connected to the input of the amplifier with an input pad and a perpendicular transmission line extending from the input pad and forming a leg of a resonant "T", and wherein the feedback network is coupled to the leg of the resonant "T".

Whole genome amplification of DNA extracted from FFPE tissues.

PubMed

Bosso, Mira; Al-Mulla, Fahd

2011-01-01

Whole genome amplification systems were developed to meet the increasing research demands on DNA resources and to avoid DNA shortage. The technology enables amplification of nanogram amounts of DNA into microgram quantities and is increasingly used in the amplification of DNA from multiple origins such as blood, fresh frozen tissue, formalin-fixed paraffin-embedded tissues, saliva, buccal swabs, bacteria, and plant and animal sources. This chapter focuses on the use of GenomePlex(®) tissue Whole Genome Amplification Kit, to amplify DNA directly from archived tissue. In addition, this chapter documents our unique experience with the utilization of GenomePlex(®) amplified DNA using several molecular techniques including metaphase Comparative Genomic Hybridization, array Comparative Genomic Hybridization, and real-time quantitative polymerase chain reaction assays. GenomePlex(®) is a registered trademark of Rubicon Genomics Incorporation.

Single-Event Effects in High-Frequency Linear Amplifiers: Experiment and Analysis

NASA Astrophysics Data System (ADS)

Zeinolabedinzadeh, Saeed; Ying, Hanbin; Fleetwood, Zachary E.; Roche, Nicolas J.-H.; Khachatrian, Ani; McMorrow, Dale; Buchner, Stephen P.; Warner, Jeffrey H.; Paki-Amouzou, Pauline; Cressler, John D.

2017-01-01

The single-event transient (SET) response of two different silicon-germanium (SiGe) X-band (8-12 GHz) low noise amplifier (LNA) topologies is fully investigated in this paper. The two LNAs were designed and implemented in 130nm SiGe HBT BiCMOS process technology. Two-photon absorption (TPA) laser pulses were utilized to induce transients within various devices in these LNAs. Impulse response theory is identified as a useful tool for predicting the settling behavior of the LNAs subjected to heavy ion strikes. Comprehensive device and circuit level modeling and simulations were performed to accurately simulate the behavior of the circuits under ion strikes. The simulations agree well with TPA measurements. The simulation, modeling and analysis presented in this paper can be applied for any other circuit topologies for SET modeling and prediction.

Suppression of stimulated Brillouin scattering in optical fibers using a linearly chirped diode laser.

PubMed

White, J O; Vasilyev, A; Cahill, J P; Satyan, N; Okusaga, O; Rakuljic, G; Mungan, C E; Yariv, A

2012-07-02

The output of high power fiber amplifiers is typically limited by stimulated Brillouin scattering (SBS). An analysis of SBS with a chirped pump laser indicates that a chirp of 2.5 × 10(15) Hz/s could raise, by an order of magnitude, the SBS threshold of a 20-m fiber. A diode laser with a constant output power and a linear chirp of 5 × 10(15) Hz/s has been previously demonstrated. In a low-power proof-of-concept experiment, the threshold for SBS in a 6-km fiber is increased by a factor of 100 with a chirp of 5 × 10(14) Hz/s. A linear chirp will enable straightforward coherent combination of multiple fiber amplifiers, with electronic compensation of path length differences on the order of 0.2 m.

Fiber networks amplify active stress

PubMed Central

Ronceray, Pierre; Broedersz, Chase P.

2016-01-01

Large-scale force generation is essential for biological functions such as cell motility, embryonic development, and muscle contraction. In these processes, forces generated at the molecular level by motor proteins are transmitted by disordered fiber networks, resulting in large-scale active stresses. Although these fiber networks are well characterized macroscopically, this stress generation by microscopic active units is not well understood. Here we theoretically study force transmission in these networks. We find that collective fiber buckling in the vicinity of a local active unit results in a rectification of stress towards strongly amplified isotropic contraction. This stress amplification is reinforced by the networks’ disordered nature, but saturates for high densities of active units. Our predictions are quantitatively consistent with experiments on reconstituted tissues and actomyosin networks and shed light on the role of the network microstructure in shaping active stresses in cells and tissue. PMID:26921325

Effect of air pollution and racism on ethnic differences in respiratory health among adolescents living in an urban environment.

PubMed

Astell-Burt, Thomas; Maynard, Maria J; Lenguerrand, Erik; Whitrow, Melissa J; Molaodi, Oarabile R; Harding, Seeromanie

2013-09-01

Recent studies suggest that stress can amplify the harm of air pollution. We examined whether experience of racism and exposure to particulate matter with an aerodynamic diameter of less than 2.5 µm and 10 µm (PM2.5 and PM10) had a synergistic influence on ethnic differences in asthma and lung function across adolescence. Analyses using multilevel models showed lower forced expiratory volume (FEV1), forced vital capacity (FVC) and lower rates of asthma among some ethnic minorities compared to Whites, but higher exposure to PM2.5, PM10 and racism. Racism appeared to amplify the relationship between asthma and air pollution for all ethnic groups, but did not explain ethnic differences in respiratory health. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy

PubMed Central

Wilson, Jesse W.; Park, Jong Kang; Warren, Warren S.

2015-01-01

The lock-in amplifier is a critical component in many different types of experiments, because of its ability to reduce spurious or environmental noise components by restricting detection to a single frequency and phase. One example application is pump-probe microscopy, a multiphoton technique that leverages excited-state dynamics for imaging contrast. With this application in mind, we present here the design and implementation of a high-speed lock-in amplifier on the field-programmable gate array (FPGA) coprocessor of a data acquisition board. The most important advantage is the inherent ability to filter signals based on more complex modulation patterns. As an example, we use the flexibility of the FPGA approach to enable a novel pump-probe detection scheme based on spread-spectrum communications techniques. PMID:25832238

Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy.

PubMed

Wilson, Jesse W; Park, Jong Kang; Warren, Warren S; Fischer, Martin C

2015-03-01

The lock-in amplifier is a critical component in many different types of experiments, because of its ability to reduce spurious or environmental noise components by restricting detection to a single frequency and phase. One example application is pump-probe microscopy, a multiphoton technique that leverages excited-state dynamics for imaging contrast. With this application in mind, we present here the design and implementation of a high-speed lock-in amplifier on the field-programmable gate array (FPGA) coprocessor of a data acquisition board. The most important advantage is the inherent ability to filter signals based on more complex modulation patterns. As an example, we use the flexibility of the FPGA approach to enable a novel pump-probe detection scheme based on spread-spectrum communications techniques.

Amplifying the helicopter drift in a conformal HMD

NASA Astrophysics Data System (ADS)

Schmerwitz, Sven; Knabl, Patrizia M.; Lueken, Thomas; Doehler, Hans-Ullrich

2016-05-01

Helicopter operations require a well-controlled and minimal lateral drift shortly before ground contact. Any lateral speed exceeding this small threshold can cause a dangerous momentum around the roll axis, which may cause a total roll over of the helicopter. As long as pilots can observe visual cues from the ground, they are able to easily control the helicopter drift. But whenever natural vision is reduced or even obscured, e.g. due to night, fog, or dust, this controllability diminishes. Therefore helicopter operators could benefit from some type of "drift indication" that mitigates the influence of a degraded visual environment. Generally humans derive ego motion by the perceived environmental object flow. The visual cues perceived are located close to the helicopter, therefore even small movements can be recognized. This fact was used to investigate a modified drift indication. To enhance the perception of ego motion in a conformal HMD symbol set the measured movement was used to generate a pattern motion in the forward field of view close or on the landing pad. The paper will discuss the method of amplified ego motion drift indication. Aspects concerning impact factors like visualization type, location, gain and more will be addressed. Further conclusions from previous studies, a high fidelity experiment and a part task experiment, will be provided. A part task study will be presented that compared different amplified drift indications against a predictor. 24 participants, 15 holding a fixed wing license and 4 helicopter pilots, had to perform a dual task on a virtual reality headset. A simplified control model was used to steer a "helicopter" down to a landing pad while acknowledging randomly placed characters.

Exposure to music and noise-induced hearing loss (NIHL) among professional pop/rock/jazz musicians.

PubMed

Halevi-Katz, Dana N; Yaakobi, Erez; Putter-Katz, Hanna

2015-01-01

Noise-induced hearing loss (NIHL) has been extensively studied in industrial work environments. With the advent of new technologies, loud music has been increasingly affecting listeners outside of the industrial setting. Most research on the effects of music and hearing loss has focused on classical musicians. The purpose of the current study was to examine the relationship between the amount of experience a professional pop/rock/jazz musician has and objective and subjective variables of the musician's hearing loss. This study also examined professional pop/rock/jazz musicians' use of hearing protection devices in relation to the extent of their exposure to amplified music. Forty-four pop/rock/jazz musicians were interviewed using the Pop/Rock/Jazz Musician's Questionnaire (PRJMQ) in order to obtain self-reported symptoms of tinnitus and hyperacusis. Forty-two of the subjects were also tested for air-conduction hearing thresholds in the frequency range of 1-8 kHz. Results show that the extent of professional pop/rock/jazz musicians' exposure to amplified music was related to both objective and subjective variables of hearing loss: Greater musical experience was positively linked to higher hearing thresholds in the frequency range of 3-6 kHz and to the subjective symptom of tinnitus. Weekly hours playing were found to have a greater effect on hearing loss in comparison to years playing. Use of hearing protection was not linked to the extent of exposure to amplified music. It is recommended that further research be conducted with a larger sample, in order to gain a greater understanding of the detrimental effects of hours playing versus years playing.

Exposure to music and noise-induced hearing loss (NIHL) among professional pop/rock/jazz musicians

PubMed Central

Halevi-Katz, Dana N.; Yaakobi, Erez; Putter-Katz, Hanna

2015-01-01

Noise-induced hearing loss (NIHL) has been extensively studied in industrial work environments. With the advent of new technologies, loud music has been increasingly affecting listeners outside of the industrial setting. Most research on the effects of music and hearing loss has focused on classical musicians. The purpose of the current study was to examine the relationship between the amount of experience a professional pop/rock/jazz musician has and objective and subjective variables of the musician's hearing loss. This study also examined professional pop/rock/jazz musicians’ use of hearing protection devices in relation to the extent of their exposure to amplified music. Forty-four pop/rock/jazz musicians were interviewed using the Pop/Rock/Jazz Musician's Questionnaire (PRJMQ) in order to obtain self-reported symptoms of tinnitus and hyperacusis. Forty-two of the subjects were also tested for air-conduction hearing thresholds in the frequency range of 1-8 kHz. Results show that the extent of professional pop/rock/jazz musicians’ exposure to amplified music was related to both objective and subjective variables of hearing loss: Greater musical experience was positively linked to higher hearing thresholds in the frequency range of 3-6 kHz and to the subjective symptom of tinnitus. Weekly hours playing were found to have a greater effect on hearing loss in comparison to years playing. Use of hearing protection was not linked to the extent of exposure to amplified music. It is recommended that further research be conducted with a larger sample, in order to gain a greater understanding of the detrimental effects of hours playing versus years playing. PMID:25913555

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ragan, Eric D; Bowman, Doug A; Scerbo, Siroberto

Virtual reality (VR) systems have been proposed for use in numerous training scenarios, such as room clearing, which require the trainee to maintain spatial awareness. But many VR training systems lack a fully surrounding display, requiring trainees to use a combination of physical and virtual turns to view the environment, thus decreasing spatial awareness. One solution to this problem is to amplify head rotations, such that smaller physical turns are mapped to larger virtual turns, allowing trainees to view the surrounding environment with head movements alone. For example, in a multi-monitor system covering only a 90-degree field of regard, headmore » rotations could be amplified four times to allow the user to see the entire 360-degree surrounding environment. This solution is attractive because it can be used with lower-cost VR systems and does not require virtual turning. However, the effects of amplified head rotations on spatial awareness and training transfer are not well understood. We hypothesized that small amounts of amplification might be tolerable, but that larger amplifications might cause trainees to become disoriented and to have decreased task performance and training transfer. In this paper, we will present our findings from an experiment designed to investigate these hypotheses. The experiment placed users in a virtual warehouse and asked them to move from room to room, counting objects placed around them in space. We varied the amount of amplification applied during these trials, and also varied the type of display used (head-mounted display or CAVE). We measured task performance and spatial awareness. We then assessed training transfer in an assessment environment with a fully surrounding display and no amplification. The results of this study will inform VR training system developers about the potential negative effects of using head rotation amplification and contribute to more effective VR training system design.« less

Hydraulic manipulator design, analysis, and control at Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kress, R.L.; Jansen, J.F.; Love, L.J.

1996-09-01

To meet the increased payload capacities demanded by present-day tasks, manipulator designers have turned to hydraulics as a means of actuation. Hydraulics have always been the actuator of choice when designing heavy-life construction and mining equipment such as bulldozers, backhoes, and tunneling devices. In order to successfully design, build, and deploy a new hydraulic manipulator (or subsystem) sophisticated modeling, analysis, and control experiments are usually needed. To support the development and deployment of new hydraulic manipulators Oak Ridge National Laboratory (ORNL) has outfitted a significant experimental laboratory and has developed the software capability for research into hydraulic manipulators, hydraulic actuators,more » hydraulic systems, modeling of hydraulic systems, and hydraulic controls. The hydraulics laboratory at ORNL has three different manipulators. First is a 6-Degree-of-Freedom (6-DoF), multi-planer, teleoperated, flexible controls test bed used for the development of waste tank clean-up manipulator controls, thermal studies, system characterization, and manipulator tracking. Finally, is a human amplifier test bed used for the development of an entire new class of teleoperated systems. To compliment the hardware in the hydraulics laboratory, ORNL has developed a hydraulics simulation capability including a custom package to model the hydraulic systems and manipulators for performance studies and control development. This paper outlines the history of hydraulic manipulator developments at ORNL, describes the hydraulics laboratory, discusses the use of the equipment within the laboratory, and presents some of the initial results from experiments and modeling associated with these hydraulic manipulators. Included are some of the results from the development of the human amplifier/de-amplifier concepts, the characterization of the thermal sensitivity of hydraulic systems, and end-point tracking accuracy studies. Experimental and analytical results are included.« less

Influence of changing surface temperature gradients on mid-latitudinal circulation and western hemispheric summer temperature extremes

NASA Astrophysics Data System (ADS)

Kornhuber, Kai; Hoffmann, Peter; Coumou, Dim

2017-04-01

Many recent summers in the Northern hemisphere (NH) mid-latitudes have seen severe heatwaves (2003, 2004, 2009, 2010, 2012, 2015, (Black et al. 2004; Diffenbaugh & Scherer 2013; Russo et al. 2014; Hoy et al. 2016)). During many of those extremes the mid-latitudinal tropospheric circulation was characterized by an amplified, quasi-stationary and hemispheric wave pattern with a dominant influence of wavenumber seven (Coumou et al. 2014; Petoukhov et al. 2016; Kornhuber et al. 2016). Analyzing NH summer reanalysis data we show that the position where these heat extremes occur is not arbitrary. If the amplitude of wave seven is large, the wave gets "locked" in a specific preferred phase position. As a consequence of this phase-locking behavior some regions are more likely to experience extreme weather during high-amplitude events. Meridional wind speeds associated with the preferred phase are particularly strong over longitudes of the western hemisphere (180°W - 40°E) leading to positive temperature anomalies over the US and Western Europe. Using a widely-used blocking-index we demonstrate that longitudes over these regions experience an increased probability of blocking during high amplitude wave seven events. We show that during the above mentioned extreme summers, amplified waves were locked in their preferred phase-position creating the right dynamical background condition for severe heatwaves to occur. Further, regression analyses reveal that a pronounced Ocean - Land temperature contrast (Tdiff) and weak poleward surface temperature gradient (dT/dy) are associated with an amplified wave seven in its preferred phase-position. Our study suggests that the observed positive trend in Tdiff and negative trend in dT/dy favors the occurrence of high-amplitude, quasi-stationary wave seven in its preferred phase position and therefore persistent heatwaves in the US and western Europe.

A new driving method for piezo deformable mirrors: open loop control and MOAO made easy

NASA Astrophysics Data System (ADS)

Ouattara, Issa; Gach, Jean-Luc; Amram, Philippe

2016-07-01

This paper presents the design and the realisation of a technique to attenuate the hysteresis nonlinear phenomenon of piezoelectric actuators. Piezoelectric actuator are widely utilised for deformable mirrors used for MOAO and power laser beam shaping techniques. The nonlinearities of piezo are usually iteratively compensa- ted using closed-loop set-ups. In open-loop control, the hysteresis and the creep of the piezo cannot be corrected, thus this nonlinearities must be removed or at least minimised. The concept has been demonstrated on high displacement Amplified Piezoelectric Actuators (APA) mounted in a Fabry-Perot interferometer. The hysteresis attenuation technique aims to assist the Fabry-Perots nano-positioning control system to attain its main scientific specification. In such system, each APA has a maximum stroke of 270 μm within a 170 V (-20 V to +150 V) range and is used to position a high reflective mirror plate. The Fabry-Perots nano-positioning control system is specified to limit the APAs positioning steady-state noise to 3nm rms, but the hysteresis limits the positioning accuracy. In order to attenuate hysteresis, a hybrid amplifier circuit built with a high power operational amplifier has been designed and applied for each APA. The experiments results show that the hysteresis effect has almost been eliminated, and consequently the positioning steady-state noise can significantly been reduced. Because of the excellent results of this hybrid amplifier, a patent application has been introduced in June 12, 2015 under number No.1555381 and is being reviewed now.

Detection of Theileria annulata in blood samples of carrier cattle by PCR.

PubMed Central

d'Oliveira, C; van der Weide, M; Habela, M A; Jacquiet, P; Jongejan, F

1995-01-01

We report the detection of Theileria annulata, the causative agent of tropical theileriosis, by PCR in blood samples obtained from carrier cattle. The assay employs primers specific for the gene encoding the 30-kDa major merozoite surface antigen of T. annulata. A 721-bp fragment was amplified from blood samples taken monthly from calves experimentally infected with one of four different stocks of T. annulata originating in either Mauritania, Portugal, Spain, or Turkey. At the end of the experiment, five animals carried the infection for 12 months and two animals remained infected for 15 months. DNAs from six other Theileria species, T. parva, T. mutans, T. sergenti, T. buffeli, T. velifera, and T. taurotragi, were not amplified. Moreover, DNAs from four other hemoparasites (Anaplasma centrale, Anaplasma marginale, Babesia bovis, and Babesia bigemina) were also not amplified. As a control, primers derived from the small subunit rRNA gene of Theileria spp. amplified a 1.1-kb DNA fragment from all Theileria species examined but not from the other four hemoparasites. As few as two to three parasites per microliter of infected blood in a 50-microliters sample volume were detected by Southern or microplate hybridization with a T. annulata-specific cDNA probe. In addition, 92 field samples obtained from cattle in Spain were tested; 22% were positive in blood smears, 40% were positive by immunofluorescent antibody test, and 75% were positive for T. annulata by PCR. The method provides a useful diagnostic tool for detecting T. annulata carrier cattle. PMID:8567902

Observation of quantum jumps in a superconducting quantum bit

NASA Astrophysics Data System (ADS)

Vijay, R.

2011-03-01

Superconducting qubit technology has made great advances since the first demonstration of coherent oscillations more than 10 years ago. Coherence times have improved by several orders of magnitude and significant progress has been made in qubit state readout fidelity. However, a fast, high-fidelity, quantum non-demolition measurement scheme which is essential to implement quantum error correction has so far been missing. We demonstrate such a scheme for the first time where we continuously measure the state of a superconducting quantum bit using a fast, ultralow-noise parametric amplifier. This arrangement allows us to observe quantum jumps between the qubit states in real time. The key development enabling this experiment is the use of a low quality factor (Q), nonlinear resonator to implement a phase-sensitive parametric amplifier operating near the quantum limit. The nonlinear resonator was constructed using a two junction SQUID shunted with an on-chip capacitor. The SQUID allowed us to tune the operating band of the amplifier and the low Q provided us with a bandwidth greater than 10 MHz, sufficient to observe jumps in the qubit state in real time. I will briefly describe the operation of the parametric amplifier and discuss how it was used to measure the state of a transmon qubit in the circuit QED architecture. I will discuss measurement fidelity and the statistics of the quantum jumps. I will conclude by discussing the implications of this development for quantum information processing and further improvements to the measurement technique. We acknowledge support from AFOSR and the Hertz Foundation.

Tunable microstrip SQUID amplifiers for the Gen 2 Axion Dark Matter eXperiment (ADMX)

NASA Astrophysics Data System (ADS)

O'Kelley, Sean; Hilton, Gene; Clarke, John; ADMX Collaboration

2016-03-01

We present a series of tunable microstrip SQUID (Superconducting Quantum Interference Device) amplifiers (MSAs) for installation in ADMX. The axion dark matter candidate is detected via Primakoff conversion to a microwave photon in a high-Q (~100,000) tunable microwave cavity cooled with a dilution refrigerator in a 7-tesla magnetic field. The microwave photon frequency ν is a function of the unknown axion mass, so both the cavity and amplifier must be scanned over a wide frequency range. An MSA is a linear, phase-preserving amplifier consisting of a square washer loop, fabricated from a thin Nb film, incorporating two Josephson tunnel junctions with resistive shunts to prevent hysteresis. The input is coupled via a microstrip made from a square Nb coil deposited over the washer with an intervening insulating layer. Tunability is achieved by terminating the microstrip with GaAs varactors that operate below 100 mK. By varying the varactor capacitance with a bias voltage, the resonant frequency is varied by up to a factor of 2. We demonstrate several devices operating below 100 mK, matched to the discrete operating bands of ADMX at frequencies ranging from 560 MHz to 1 GHz. The MSAs exhibit gains exceeding 20 dB and the associated noise temperatures, measured with a hot/cold load, approach the standard quantum limit (hν/kB) . Supported by DOE Grants DE - FG02 - 97ER41029, DE - FG02 - 96ER40956, DE - AC52 - 07NA27344, DE - AC03 - 76SF00098, and the Livermore LDRD program.

KSC-2009-1090

NASA Image and Video Library

2009-01-09

CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, an overhead crane lowers the ICS Exposed Facility, or ICS-EF, onto the Japanese Experiment Module's Experiment Logistics Module-Exposed Section, or ELM-ES, for installation. The ICS-EF is composed of several components, including an antenna, pointing mechanism, frequency converters, high-power amplifier and various sensors including the Earth sensor, Sun sensor and inertial reference unit. The ICS-EF is part of space shuttle Endeavour's payload on the STS-127 mission, targeted for launch on May 15. Photo credit: NASA/Jim Grossmann

KSC-2009-1085

NASA Image and Video Library

2009-01-09

CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, workers prepare the ICS Exposed Facility, ICS-EF, to be lifted and installed on the Japanese Experiment Module's Experiment Logistics Module-Exposed Section, or ELM-ES. The ICS-EF is composed of several components, including an antenna, pointing mechanism, frequency converters, high-power amplifier and various sensors including the Earth sensor, Sun sensor and inertial reference unit. The ICS-EF is part of space shuttle Endeavour's payload on the STS-127 mission, targeted for launch on May 15. Photo credit: NASA/Jim Grossmann

Low-Noise Band-Pass Amplifier

NASA Technical Reports Server (NTRS)

Kleinberg, L.

1982-01-01

Circuit uses standard components to overcome common limitation of JFET amplifiers. Low-noise band-pass amplifier employs JFET and operational amplifier. High gain and band-pass characteristics are achieved with suitable choice of resistances and capacitances. Circuit should find use as low-noise amplifier, for example as first stage instrumentation systems.

Applications of Optical Coherent Transient Technology to Pulse Shaping, Spectral Filtering, Arbitrary Waveform Generation and RF Beamforming

DTIC Science & Technology

2006-04-15

was amplified by injection locking of a high power diode laser and further amplified to -300 mW with a semiconductor optical amplifier. This light...amplifiers at 793nm, cascaded injection locked amplifiers at 793nm, and frequency chirped lasers at 793nm. 15. SUBJECT TERMS Optical Coherent Transients...injection- locking for broadband optical signal amplification ................. 34 2.10. Tapered semiconductor optical amplifier

Visual neurophysiology: a field-effect amplifier designed and built by R. L. De Valois.

PubMed

Albrecht, Duane G; Creeger, Carl P; Crane, Alison M

2005-10-01

In the middle of the last century, R. L. De Valois designed and built a unique and effective amplifier based on the newly developed field-effect transistor (FET). This amplifier has many beneficial qualities for amplifying the signals of neurons with minimal disturbance. We have used this amplifier successfully for more than three decades. We describe the circuitry of the De Valois amplifier and provide performance specifications. The FET amplifier is one of De Valois's contributions to visual neurophysiology; we share the design in his honor, with the hope that it might prove useful to others.

Amplifier for measuring low-level signals in the presence of high common mode voltage

NASA Technical Reports Server (NTRS)

Lukens, F. E. (Inventor)

1985-01-01

A high common mode rejection differential amplifier wherein two serially arranged Darlington amplifier stages are employed and any common mode voltage is divided between them by a resistance network. The input to the first Darlington amplifier stage is coupled to a signal input resistor via an amplifier which isolates the input and presents a high impedance across this resistor. The output of the second Darlington stage is transposed in scale via an amplifier stage which has its input a biasing circuit which effects a finite biasing of the two Darlington amplifier stages.

ULTRA-STABILIZED D. C. AMPLIFIER

DOEpatents

Hartwig, E.C.; Kuenning, R.W.; Acker, R.C.

1959-02-17

An improved circuit is described for stabilizing the drift and minimizing the noise and hum level of d-c amplifiers so that the output voltage will be zero when the input is zero. In its detailed aspects, the disclosed circuit incorporates a d-c amplifier having a signal input, a second input, and an output circuit coupled back to the first input of the amplifier through inverse feedback means. An electronically driven chopper having a pair of fixed contacts and a moveable contact alternately connects the two inputs of a difference amplifier to the signal input. The A. E. error signal produced in the difference amplifier is amplified, rectified, and applied to the second input of the amplifier as the d-c stabilizing voltage.

High-power piezo drive amplifier for large stack and PFC applications

NASA Astrophysics Data System (ADS)

Clingman, Dan J.; Gamble, Mike

2001-08-01

This paper describes the continuing development of Boeing High Power Piezo Drive Amplifiers. Described is the development and testing of a 1500 Vpp, 8 amp switching amplifier. This amplifier is used to drive a piezo stack driven rotor blade trailing edge flap on a full size helicopter. Also discuss is a switching amplifier designed to drive a Piezo Fiber Composite (PFC) active twist rotor blade. This amplifier was designed to drive the PFC material at 2000 Vpp and 0.5 amps. These amplifiers recycle reactive energy, allowing for a power and weight efficient amplifier design. This work was done in conjunction with the DARPA sponsored Phase II Smart Rotor Blade program and the NASA Langley Research Center sponsored Active Twist Rotor (ATR) blade program.

Portable musical instrument amplifier

DOEpatents

Christian, David E.

1990-07-24

The present invention relates to a musical instrument amplifier which is particularly useful for electric guitars. The amplifier has a rigid body for housing both the electronic system for amplifying and processing signals from the guitar and the system's power supply. An input plug connected to and projecting from the body is electrically coupled to the signal amplifying and processing system. When the plug is inserted into an output jack for an electric guitar, the body is rigidly carried by the guitar, and the guitar is operatively connected to the electrical amplifying and signal processing system without use of a loose interconnection cable. The amplifier is provided with an output jack, into which headphones are plugged to receive amplified signals from the guitar. By eliminating the conventional interconnection cable, the amplifier of the present invention can be used by musicians with increased flexibility and greater freedom of movement.

Synthetic Lethal Metabolic Targeting of Senescent Cells After Androgen Deprivation Therapy

DTIC Science & Technology

2017-07-01

and improved cell killing. 15. SUBJECT TERMS prostate cancer, androgen deprivation therapy, senescence, proteotoxic stress , xenograft models...these persistent senescent cells is characterized by increased protein synthesis and notably an amplified proteotoxic stress response (PSR), a...experience high levels of proteotoxic stress . In Aim 1 we will examine the activity of metformin in eradicating senescent PCs following ADT in

21-nm-range wavelength-tunable L-band Er-doped fiber linear-cavity laser

NASA Astrophysics Data System (ADS)

Yang, Shiquan; Zhao, Chunliu; Li, Zhaohui; Ding, Lei; Yuan, Shuzhong; Dong, Xiaoyi

2001-10-01

A novel method, which utilizes amplified spontaneous emission (ASE) as a secondary pump source, is presented for implanting a linear cavity erbium-doped fiber laser operating in L-Band. The output wavelength tuned from 1566 nm to 1587 nm, about 21 nm tuning range, was obtained in the experiment and the stability of the laser is very good.

Face-to-face: Perceived personal relevance amplifies face processing

PubMed Central

Pittig, Andre; Schupp, Harald T.; Alpers, Georg W.

2017-01-01

Abstract The human face conveys emotional and social information, but it is not well understood how these two aspects influence face perception. In order to model a group situation, two faces displaying happy, neutral or angry expressions were presented. Importantly, faces were either facing the observer, or they were presented in profile view directed towards, or looking away from each other. In Experiment 1 (n = 64), face pairs were rated regarding perceived relevance, wish-to-interact, and displayed interactivity, as well as valence and arousal. All variables revealed main effects of facial expression (emotional > neutral), face orientation (facing observer > towards > away) and interactions showed that evaluation of emotional faces strongly varies with their orientation. Experiment 2 (n = 33) examined the temporal dynamics of perceptual-attentional processing of these face constellations with event-related potentials. Processing of emotional and neutral faces differed significantly in N170 amplitudes, early posterior negativity (EPN), and sustained positive potentials. Importantly, selective emotional face processing varied as a function of face orientation, indicating early emotion-specific (N170, EPN) and late threat-specific effects (LPP, sustained positivity). Taken together, perceived personal relevance to the observer—conveyed by facial expression and face direction—amplifies emotional face processing within triadic group situations. PMID:28158672

Land–atmosphere feedbacks amplify aridity increase over land under global warming

USGS Publications Warehouse

Berg, Alexis; Findell, Kirsten; Lintner, Benjamin; Giannini, Alessandra; Seneviratne, Sonia I.; van den Hurk, Bart; Lorenz, Ruth; Pitman, Andy; Hagemann, Stefan; Meier, Arndt; Cheruy, Frédérique; Ducharne, Agnès; Malyshev, Sergey; Milly, Paul C. D.

2016-01-01

The response of the terrestrial water cycle to global warming is central to issues including water resources, agriculture and ecosystem health. Recent studies indicate that aridity, defined in terms of atmospheric supply (precipitation, P) and demand (potential evapotranspiration, Ep) of water at the land surface, will increase globally in a warmer world. Recently proposed mechanisms for this response emphasize the driving role of oceanic warming and associated atmospheric processes. Here we show that the aridity response is substantially amplified by land–atmosphere feedbacks associated with the land surface’s response to climate and CO2 change. Using simulations from the Global Land Atmosphere Coupling Experiment (GLACE)-CMIP5 experiment, we show that global aridity is enhanced by the feedbacks of projected soil moisture decrease on land surface temperature, relative humidity and precipitation. The physiological impact of increasing atmospheric CO2 on vegetation exerts a qualitatively similar control on aridity. We reconcile these findings with previously proposed mechanisms by showing that the moist enthalpy change over land is unaffected by the land hydrological response. Thus, although oceanic warming constrains the combined moisture and temperature changes over land, land hydrology modulates the partitioning of this enthalpy increase towards increased aridity.

Standard deviation index for stimulated Brillouin scattering suppression with different homogeneities.

PubMed

Ran, Yang; Su, Rongtao; Ma, Pengfei; Wang, Xiaolin; Zhou, Pu; Si, Lei

2016-05-10

We present a new quantitative index of standard deviation to measure the homogeneity of spectral lines in a fiber amplifier system so as to find the relation between the stimulated Brillouin scattering (SBS) threshold and the homogeneity of the corresponding spectral lines. A theoretical model is built and a simulation framework has been established to estimate the SBS threshold when input spectra with different homogeneities are set. In our experiment, by setting the phase modulation voltage to a constant value and the modulation frequency to different values, spectral lines with different homogeneities can be obtained. The experimental results show that the SBS threshold increases negatively with the standard deviation of the modulated spectrum, which is in good agreement with the theoretical results. When the phase modulation voltage is confined to 10 V and the modulation frequency is set to 80 MHz, the standard deviation of the modulated spectrum equals 0.0051, which is the lowest value in our experiment. Thus, at this time, the highest SBS threshold has been achieved. This standard deviation can be a good quantitative index in evaluating the power scaling potential in a fiber amplifier system, which is also a design guideline in suppressing the SBS to a better degree.

Covalent complexes of albumin with serotonin, ketanserin and lysergic acid antagonize the activity of serotonin in human platelets

DOE Office of Scientific and Technical Information (OSTI.GOV)

VanderBerg, S.R.; Gonias, S.L.

1989-01-01

Covalent conjugates of bovine serum albumin (BSA) and 5-HT, ketanserin or d-lysergic acid were synthesized and characterized by polyacrylamide gel electrophoresis, whole blood clearance experiments in mice and aggregation studies with human platelets. Using the standard synthesis procedure, each mol of BSA bound 13.4 mol of (/sup 3/H)5-HT. Derivatization did not cause significant protein aggregation as determined by electrophoresis. All three conjugates antagonized the ability of 5-HT to amplify aggregation caused by low concentrations of ADP. The antagonist activity of each conjugate was concentration dependent; 2.6 ..mu..M 5-HT-BSA completely inhibited the aggregation caused by 13 ..mu..M 5-HT. None of themore » BSA drug conjugates, including 5-HT-BSA, amplified platelet aggregation caused by ADP in the absence of 5-HT. Aggregation by ristocetin, collagen, epinephrine or ADP alone was not significantly affected by the conjugates. Whole blood elimination experiments in mice demonstrated that the three conjugates and underivatized BSA are equally stable in the circulation. These prototypic 5-HT drug-protein conjugates may be useful for probing 5-HT/sub 2/ receptor-ligand interactions in human platelets.« less

Dr. Peter Cavanaugh Explains the Need and Operation of the FOOT Experiment

NASA Technical Reports Server (NTRS)

2003-01-01

This video clip is an interview with Dr. Peter Cavanaugh, principal investigator for the FOOT experiment. He explains the reasoning behind the experiment and shows some video clips of the FOOT experiment being calibrated and conducted in orbit. The heart of the FOOT experiment is an instrumented suit called the Lower Extremity Monitoring Suit (LEMS). This customized garment is a pair of Lycra cycling tights incorporating 20 carefully placed sensors and the associated wiring control units, and amplifiers. LEMS enables the electrical activity of the muscles, the angular motions of the hip, knee, and ankle joints, and the force under both feet to be measured continuously. Measurements are also made on the arm muscles. Information from the sensors can be recorded up to 14 hours on a small, wearable computer.

Gated frequency-resolved optical imaging with an optical parametric amplifier

DOEpatents

Cameron, S.M.; Bliss, D.E.; Kimmel, M.W.; Neal, D.R.

1999-08-10

A system for detecting objects in a turbid media utilizes an optical parametric amplifier as an amplifying gate for received light from the media. An optical gating pulse from a second parametric amplifier permits the system to respond to and amplify only ballistic photons from the object in the media. 13 figs.

Gated frequency-resolved optical imaging with an optical parametric amplifier

DOEpatents

Cameron, Stewart M.; Bliss, David E.; Kimmel, Mark W.; Neal, Daniel R.

1999-01-01

A system for detecting objects in a turbid media utilizes an optical parametric amplifier as an amplifying gate for received light from the media. An optical gating pulse from a second parametric amplifier permits the system to respond to and amplify only ballistic photons from the object in the media.

Study of beam aberrations in a germanium XXIII XUV laser amplifier

NASA Astrophysics Data System (ADS)

Smith, C. G.; Key, M. H.; Cairns, G.; Dwivedi, L.; Krishnan, J.; Lewis, C. L. S.; MacPhee, A. G.; Neely, D.; Ramsden, S. A.; Tallents, G.

1996-02-01

A beam of amplified spontaneous emission at {23.2}/{23.6}nm from a GeXXIII XUV laser has been injected into a separate amplifier plasma and the astigmatic aberrations introduced by plasma density gradients in the amplifier have been estimated from analysis of images of the amplified beam.

S-band low noise amplifier and 40 kW high power amplifier subsystems of Japanese Deep Space Earth Station

NASA Astrophysics Data System (ADS)

Honma, K.; Handa, K.; Akinaga, W.; Doi, M.; Matsuzaki, O.

This paper describes the design and the performance of the S-band low noise amplifier and the S-band high power amplifier that have been developed for the Usuda Deep Space Station of the Institute of Space and Astronautical Science (ISAS), Japan. The S-band low noise amplifier consists of a helium gas-cooled parametric amplifier followed by three-stage FET amplifiers and has a noise temperature of 8 K. The high power amplifier is composed of two 28 kW klystrons, capable of transmitting 40 kW continuously when two klystrons are combined. Both subsystems are operating quite satisfactorily in the tracking of Sakigake and Suisei, the Japanese interplanetary probes for Halley's comet exploration, launched by ISAS in 1985.

A low-noise current-sensitive amplifier-discriminator system for beta particle counting.

PubMed

Sephton, J P; Johansson, L C; Williams, J M

2008-01-01

NPL has developed a low-noise current amplifier/discriminator system for radionuclides that emit low-energy electrons and X-rays. The new beta amplifier is based on the low-noise Amptek A-250 operational amplifier. The design has been configured for optimum signal to noise ratio. The new amplifier is described and results obtained using primarily electron-capture decaying radionuclides are presented. The new amplifier gives rise to higher particle detection efficiency than the previously used Atomic Energy of Canada Limited-designed amplifier. This is shown by measurements of (54)Mn and (65)Zn. The counting plateaux are significantly longer and have reduced gradients.

Low phase noise oscillator using two parallel connected amplifiers

NASA Technical Reports Server (NTRS)

Kleinberg, Leonard L.

1987-01-01

A high frequency oscillator is provided by connecting two amplifier circuits in parallel where each amplifier circuit provides the other amplifier circuit with the conditions necessary for oscillation. The inherent noise present in both amplifier circuits causes the quiescent current, and in turn, the generated frequency, to change. The changes in quiescent current cause the transconductance and the load impedance of each amplifier circuit to vary, and this in turn results in opposing changes in the input susceptance of each amplifier circuit. Because the changes in input susceptance oppose each other, the changes in quiescent current also oppose each other. The net result is that frequency stability is enhanced.

The warm, rich sound of valve guitar amplifiers

NASA Astrophysics Data System (ADS)

Keeports, David

2017-03-01

Practical solid state diodes and transistors have made glass valve technology nearly obsolete. Nevertheless, valves survive largely because electric guitar players much prefer the sound of valve amplifiers to the sound of transistor amplifiers. This paper discusses the introductory-level physics behind that preference. Overdriving an amplifier adds harmonics to an input sound. While a moderately overdriven valve amplifier produces strong even harmonics that enhance a sound, an overdriven transistor amplifier creates strong odd harmonics that can cause dissonance. The functioning of a triode valve explains its creation of even and odd harmonics. Music production software enables the examination of both the wave shape and the harmonic content of amplified sounds.

Multifrequency Raman amplifiers

NASA Astrophysics Data System (ADS)

Barth, Ido; Fisch, Nathaniel J.

2018-03-01

In its usual implementation, the Raman amplifier features only one pump carrier frequency. However, pulses with well-separated frequencies can also be Raman amplified while compressed in time. Amplification with frequency-separated pumps is shown to hold even in the highly nonlinear, pump-depletion regime, as derived through a fluid model, and demonstrated via particle-in-cell simulations. The resulting efficiency is similar to single-frequency amplifiers, but, due to the beat-wave waveform of both the pump lasers and the amplified seed pulses, these amplifiers feature higher seed intensities with a shorter spike duration. Advantageously, these amplifiers also suffer less noise backscattering, because the total fluence is split between the different spectral components.

Case-Study Investigation of Equine Maternity via PCR-RFLP: A Biochemistry Laboratory Experiment

PubMed Central

Millard, Julie T.; Chuang, Edward; Lucas, James S.; Nagy, Erzsebet E.; Davis, Griffin T.

2013-01-01

A simple and robust biochemistry laboratory experiment is described that uses restriction fragment length polymorphism (RFLP) of polymerase chain reaction (PCR) products to verify the identity of a potentially valuable horse. During the first laboratory period, students purify DNA from equine samples and amplify two loci of mitochondrial DNA. During the second laboratory period, students digest PCR products with restriction enzymes and analyze the fragment sizes through agarose gel electrophoresis. An optional step of validating DNA extracts through realtime PCR can expand the experiment to three weeks. This experiment, which has an engaging and versatile scenario, provides students with exposure to key principles and techniques of molecular biology, bioinformatics, and evolution in a forensic context. PMID:24363455

Bio-isolated dc operational amplifier. [for bioelectric measurements

NASA Technical Reports Server (NTRS)

Lee, R. D. (Inventor)

1974-01-01

A bio-isolated dc operational amplifier is described for use in making bioelectrical measurements of a patient while providing isolation of the patient from electrical shocks. The circuit contains a first operational amplifier coupled to the patient with its output coupled in a forward loop through a first optic coupler to a second operational amplifier. The output of the second operational amplifier is coupled to suitable monitoring circuitry via a feedback circuit including a second optic coupler to the input of the first operational amplifier.

Direct Current Amplifier. Report No. 92; AMPLIFICADOR DE CORRIENTE CONTINUA. Informe No. 92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marazzi, C.

1963-01-01

A direct-current amplifier with low zero current and solid-state chopper for input is described. This amplifier can be used in control circuits and for general applications such as temperature measurement in thermocouples, amplifier for a photo-sensitive element, or zero amplifier in control systems. The input impedance is relatively low, serving principally as current amplifier. It is possible to obtain a symmetry characteristic for positive and negative values of the output voltage with respect to the input. (tr-auth)

Laser amplifier chain

DOEpatents

Hackel, Richard P.

1992-01-01

A laser amplifier chain has a plurality of laser amplifiers arranged in a chain to sequentially amplify a low-power signal beam to produce a significantly higher-power output beam. Overall efficiency of such a chain is improved if high-gain, low efficiency amplifiers are placed on the upstream side of the chain where only a very small fraction of the total pumped power is received by the chain and low-gain, high-efficiency amplifiers are placed on the downstream side where a majority of pumping energy is received by the chain.

Direct solar-pumped iodine laser amplifier

NASA Technical Reports Server (NTRS)

Han, K. S.

1985-01-01

This semiannual progress report covers the period from April 1, 1985 to Sept. 30, 1985 under NASA grant NAS1-441 entitled direct solar pumped iodine laser amplifier. During this period the parametric studies of the iodine laser oscillator pumped by a Vortek simulator was carried out before the amplifier studies. The amplifier studies are postponed to the extended period following completion of the parametric studies. In addition, the kinetic modeling of a solar pumped iodine laser amplifier, and the experimental work for a solar pumped dye laser amplifier are in progress. This report contains three parts: (1) the radiation characteristics of solar simulator and the parametric characteristics of photodissociation iodine laser continuously pumped by a Vortek solar simulator; (2) kinetic modeling of a solar pumped iodine laser amplifier; and (3) the study of the dye laser amplifier pumped by a Tamarack solar simulator.

High temperature charge amplifier for geothermal applications

DOEpatents

Lindblom, Scott C.; Maldonado, Frank J.; Henfling, Joseph A.

2015-12-08

An amplifier circuit in a multi-chip module includes a charge to voltage converter circuit, a voltage amplifier a low pass filter and a voltage to current converter. The charge to voltage converter receives a signal representing an electrical charge and generates a voltage signal proportional to the input signal. The voltage amplifier receives the voltage signal from the charge to voltage converter, then amplifies the voltage signal by the gain factor to output an amplified voltage signal. The lowpass filter passes low frequency components of the amplified voltage signal and attenuates frequency components greater than a cutoff frequency. The voltage to current converter receives the output signal of the lowpass filter and converts the output signal to a current output signal; wherein an amplifier circuit output is selectable between the output signal of the lowpass filter and the current output signal.

Biologically relevant effects of mRNA amplification on gene expression profiles.

PubMed

van Haaften, Rachel I M; Schroen, Blanche; Janssen, Ben J A; van Erk, Arie; Debets, Jacques J M; Smeets, Hubert J M; Smits, Jos F M; van den Wijngaard, Arthur; Pinto, Yigal M; Evelo, Chris T A

2006-04-11

Gene expression microarray technology permits the analysis of global gene expression profiles. The amount of sample needed limits the use of small excision biopsies and/or needle biopsies from human or animal tissues. Linear amplification techniques have been developed to increase the amount of sample derived cDNA. These amplified samples can be hybridised on microarrays. However, little information is available whether microarrays based on amplified and unamplified material yield comparable results. In the present study we compared microarray data obtained from amplified mRNA derived from biopsies of rat cardiac left ventricle and non-amplified mRNA derived from the same organ. Biopsies were linearly amplified to acquire enough material for a microarray experiment. Both amplified and unamplified samples were hybridized to the Rat Expression Set 230 Array of Affymetrix. Analysis of the microarray data showed that unamplified material of two different left ventricles had 99.6% identical gene expression. Gene expression patterns of two biopsies obtained from the same parental organ were 96.3% identical. Similarly, gene expression pattern of two biopsies from dissimilar organs were 92.8% identical to each other.Twenty-one percent of reporters called present in parental left ventricular tissue disappeared after amplification in the biopsies. Those reporters were predominantly seen in the low intensity range. Sequence analysis showed that reporters that disappeared after amplification had a GC-content of 53.7+/-4.0%, while reporters called present in biopsy- and whole LV-samples had an average GC content of 47.8+/-5.5% (P <0.001). Those reporters were also predicted to form significantly more (0.76+/-0.07 versus 0.38+/-0.1) and longer (9.4+/-0.3 versus 8.4+/-0.4) hairpins as compared to representative control reporters present before and after amplification. This study establishes that the gene expression profile obtained after amplification of mRNA of left ventricular biopsies is representative for the whole left ventricle of the rat heart. However, specific gene transcripts present in parental tissues were undetectable in the minute left ventricular biopsies. Transcripts that were lost due to the amplification process were not randomly distributed, but had higher GC-content and hairpins in the sequence and were mainly found in the lower intensity range which includes many transcription factors from specific signalling pathways.

Biologically relevant effects of mRNA amplification on gene expression profiles

PubMed Central

van Haaften, Rachel IM; Schroen, Blanche; Janssen, Ben JA; van Erk, Arie; Debets, Jacques JM; Smeets, Hubert JM; Smits, Jos FM; van den Wijngaard, Arthur; Pinto, Yigal M; Evelo, Chris TA

2006-01-01

Background Gene expression microarray technology permits the analysis of global gene expression profiles. The amount of sample needed limits the use of small excision biopsies and/or needle biopsies from human or animal tissues. Linear amplification techniques have been developed to increase the amount of sample derived cDNA. These amplified samples can be hybridised on microarrays. However, little information is available whether microarrays based on amplified and unamplified material yield comparable results. In the present study we compared microarray data obtained from amplified mRNA derived from biopsies of rat cardiac left ventricle and non-amplified mRNA derived from the same organ. Biopsies were linearly amplified to acquire enough material for a microarray experiment. Both amplified and unamplified samples were hybridized to the Rat Expression Set 230 Array of Affymetrix. Results Analysis of the microarray data showed that unamplified material of two different left ventricles had 99.6% identical gene expression. Gene expression patterns of two biopsies obtained from the same parental organ were 96.3% identical. Similarly, gene expression pattern of two biopsies from dissimilar organs were 92.8% identical to each other. Twenty-one percent of reporters called present in parental left ventricular tissue disappeared after amplification in the biopsies. Those reporters were predominantly seen in the low intensity range. Sequence analysis showed that reporters that disappeared after amplification had a GC-content of 53.7+/-4.0%, while reporters called present in biopsy- and whole LV-samples had an average GC content of 47.8+/-5.5% (P <0.001). Those reporters were also predicted to form significantly more (0.76+/-0.07 versus 0.38+/-0.1) and longer (9.4+/-0.3 versus 8.4+/-0.4) hairpins as compared to representative control reporters present before and after amplification. Conclusion This study establishes that the gene expression profile obtained after amplification of mRNA of left ventricular biopsies is representative for the whole left ventricle of the rat heart. However, specific gene transcripts present in parental tissues were undetectable in the minute left ventricular biopsies. Transcripts that were lost due to the amplification process were not randomly distributed, but had higher GC-content and hairpins in the sequence and were mainly found in the lower intensity range which includes many transcription factors from specific signalling pathways. PMID:16608515

A small, portable, battery-powered brain-computer interface system for motor rehabilitation.

PubMed

McCrimmon, Colin M; Ming Wang; Silva Lopes, Lucas; Wang, Po T; Karimi-Bidhendi, Alireza; Liu, Charles Y; Heydari, Payam; Nenadic, Zoran; Do, An H

2016-08-01

Motor rehabilitation using brain-computer interface (BCI) systems may facilitate functional recovery in individuals after stroke or spinal cord injury. Nevertheless, these systems are typically ill-suited for widespread adoption due to their size, cost, and complexity. In this paper, a small, portable, and extremely cost-efficient (<;$200) BCI system has been developed using a custom electroencephalographic (EEG) amplifier array, and a commercial microcontroller and touchscreen. The system's performance was tested using a movement-related BCI task in 3 able-bodied subjects with minimal previous BCI experience. Specifically, subjects were instructed to alternate between relaxing and dorsiflexing their right foot, while their EEG was acquired and analyzed in real-time by the BCI system to decode their underlying movement state. The EEG signals acquired by the custom amplifier array were similar to those acquired by a commercial amplifier (maximum correlation coefficient ρ=0.85). During real-time BCI operation, the average correlation between instructional cues and decoded BCI states across all subjects (ρ=0.70) was comparable to that of full-size BCI systems. Small, portable, and inexpensive BCI systems such as the one reported here may promote a widespread adoption of BCI-based movement rehabilitation devices in stroke and spinal cord injury populations.

Performance of a resistive plate chamber equipped with a new prototype of amplified front-end electronics in the ALICE detector

NASA Astrophysics Data System (ADS)

Marchisone, Massimiliano

2017-09-01

ALICE is the LHC experiment dedicated to the study of heavy-ion collisions. At forward rapidity a muon spectrometer detects muons from low mass mesons, quarkonia (c\\bar{c} and b\\bar{b} mesons), open heavy-flavor hadrons (D and B mesons) as well as from weak bosons. A muon selection based on transverse momentum is made by a trigger system composed of 72 Resistive Plate Chambers (RPCs). For the LHC Run 1 and the ongoing Run 2 the RPCs have been equipped with a non-amplified Front-End Electronics (FEE) called ADULT. However, in view of an increase in luminosity expected for Run 3 (foreseen to start in 2021) the possibility to use an amplified FEE has been explored in order to improve the counting rate limitation and to prevent the aging of the detector by reducing the charge per hit. A prototype of this new electronics (FEERIC) has been developed and tested first with cosmic rays before equipping one RPC in the ALICE cavern with it. In this proceeding the most important performance indicators (such as efficiency, dark current, dark rate, cluster size, total charge and charge per hit) of the RPC equipped with this new FEE will be reviewed and compared to the others read out with ADULT.

Performance of a resistive plate chamber equipped with a new prototype of amplified front-end electronics

NASA Astrophysics Data System (ADS)

Marchisone, Massimiliano

2016-06-01

ALICE is the LHC experiment dedicated to the study of heavy-ion collisions. At forward rapidity a muon spectrometer detects muons from low mass mesons, quarkonia, open heavy-flavor hadrons as well as weak bosons. A muon selection based on transverse momentum is made by a trigger system composed of 72 resistive plate chambers (RPCs). For the LHC Run 1 and the ongoing Run 2 the RPCs have been equipped with a non-amplified FEE called ADULT. However, in view of an increase in luminosity expected for Run 3 (2021-2023) the possibility to use an amplified FEE has been explored in order to improve the counting rate limitation and to prevent the aging of the detector, by reducing the charge per hit. A prototype of this new electronics (FEERIC) has been developed and tested first with cosmic rays before equipping one RPC in the ALICE cavern with it. In this paper the most important performance indicators— efficiency, dark current, dark rate, cluster size and total charge —of an RPC equipped with this new FEE will be reviewed and compared to the others read out with ADULT, in pp collisions at √s=5 and 13 TeV and in Pb-Pb collisions at √sNN=5 TeV.

Hydrodynamic study of plasma amplifiers for soft-x-ray lasers: a transition in hydrodynamic behavior for plasma columns with widths ranging from 20 μm to 2 mm.

PubMed

Oliva, Eduardo; Zeitoun, Philippe; Velarde, Pedro; Fajardo, Marta; Cassou, Kevin; Ros, David; Sebban, Stephan; Portillo, David; le Pape, Sebastien

2010-11-01

Plasma-based seeded soft-x-ray lasers have the potential to generate high energy and highly coherent short pulse beams. Due to their high density, plasmas created by the interaction of an intense laser with a solid target should store the highest amount of energy density among all plasma amplifiers. Our previous numerical work with a two-dimensional (2D) adaptive mesh refinement hydrodynamic code demonstrated that careful tailoring of plasma shapes leads to a dramatic enhancement of both soft-x-ray laser output energy and pumping efficiency. Benchmarking of our 2D hydrodynamic code in previous experiments demonstrated a high level of confidence, allowing us to perform a full study with the aim of the way for 10-100 μJ seeded soft-x-ray lasers. In this paper, we describe in detail the mechanisms that drive the hydrodynamics of plasma columns. We observed transitions between narrow plasmas, where very strong bidimensional flow prevents them from storing energy, to large plasmas that store a high amount of energy. Millimeter-sized plasmas are outstanding amplifiers, but they have the limitation of transverse lasing. In this paper, we provide a preliminary solution to this problem.

Longitudinal mode selection in a delay-line homogeneously broadened oscillator with a fast saturable amplifier.

PubMed

Fleyer, Michael; Horowitz, Moshe

2017-05-01

Homogeneously broadened delay-line oscillators such as lasers or optoelectronic oscillators (OEOs) can potentially oscillate in a large number of cavity modes that are supported by their amplifier bandwidth. In a continuous wave operating mode, the oscillating mode is selected between one or few cavity modes that experience the highest small-signal gain. In this manuscript, we show that the oscillation mode of a homogeneously broadened oscillator can be selected from a large number of modes in a frequency region that can be broader than the full width at half maximum of the effective cavity filter. The mode is selected by a short-time injection of an external signal into the oscillator. After the external signal is turned off, the oscillation is maintained in the selected mode even if this mode has a significantly lower small-signal gain than that of other cavity modes. The stability of the oscillation is obtained due to nonlinear saturation effect in the oscillator amplifier. We demonstrate, experimentally and theoretically, mode selection in a long cavity OEO. We could select any desired mode between 400 cavity modes while maintaining ultra-low phase noise in the selected mode and in the non-oscillating modes. No mode-hopping was observed during our maximum measurement duration of about 24 hours.

Single mode low-NA step index Yb-doped fiber design for output powers beyond 4kW (Conference Presentation)

NASA Astrophysics Data System (ADS)

Beier, Franz; Proske, Fritz; Hupel, Christian; Kuhn, Stefan; Hein, Sigrun; Sattler, Bettina; Nold, Johannes; Haarlammert, Nicoletta; Schreiber, Thomas; Eberhardt, Ramona; Tünnermann, Andreas

2017-03-01

Fiber amplifiers are representing one of the most promising solid state laser concepts, due to the compact setup size, a simple thermal management and furthermore excellent beam quality. In this contribution, we report on the latest results from a low-NA, large mode area single mode fiber with a single mode output power beyond 4 kW without any indication of mode instabilities or nonlinear effects and high slope efficiency. Furthermore, we quantify the influence of the bending diameter of our manufactured low NA fiber on the average core loss by an OFDR measurement and determine the optimal bending diameter in comparison to a second fiber with a slightly changed NA. The fibers used in the experiments were fabricated by MCVD technology combined with the solution doping technique. The investigation indicates the limitation of the step index fiber design and its influence on the use in high power fiber amplifiers. We demonstrate, that even a slightly change in the core NA crucially influences the minimum bending diameter of the fiber and has to be taken into account in applications. The measured output power represents to the best of our knowledge the highest single mode output power of an amplifier fiber ever reported on.

A velocity-amplified electromagnetic energy harvester for small amplitude vibration

NASA Astrophysics Data System (ADS)

Klein, J.; Zuo, L.

2017-09-01

Dedicated, self-powered wireless sensors are widely being studied for use throughout many industries to monitor everyday operations, maintain safety, and report performance characteristics. To enable sensors to power themselves, harvesting energy from machine vibration has been studied, however, its overall effectiveness can be hampered due to small vibration amplitudes and thus limited harvestable energy density. This paper addresses the issue by proposing a novel vibration energy harvester architecture in which a compliant mechanism and proof mass system is used to amplify the vibrational velocity of machine vibration for a linear electromagnetic generator. A prototype has been fabricated and experimentally characterized to verify its effectiveness. When operating at its natural frequency in a low base amplitude, 0.001 inch (25.4 μm) at 19.4 Hz, during lab tests, the harvester has been shown to produce up to 0.91 V AC open voltage, and a maximum power of 2 mW, amplifying the relative proof mass velocity by approximately 5.4 times. This method of locally increasing the machine vibrational velocity has been shown to be a viable option for increasing the potential power output of an energy harvester. In addition, a mathematical model is created based on pseudo-rigid-body dynamics and the analysis matches closely with experiments.

Active spectral shaping with polarization-encoded Ti:sapphire amplifiers for sub-20 fs multi-terawatt systems

NASA Astrophysics Data System (ADS)

Cao, H.; Kalashnikov, M.; Osvay, K.; Khodakovskiy, N.; Nagymihaly, R. S.; Chvykov, V.

2018-04-01

A combination of a polarization-encoded (PE) and a conventional multi-pass amplifier was studied to overcome gain narrowing in the Ti:sapphire active medium. The seed spectrum was pre-shaped and blue-shifted during PE amplification and was then further broadened in a conventional, saturated multi-pass amplifier, resulting in an overall increase of the amplified bandwidth. Using this technique, seed pulses of 44 nm were amplified and simultaneously spectrally broadened to 57 nm without the use of passive spectral corrections. The amplified pulse after the PE amplifier was recompressed to 19 fs. The supported simulations confirm all aspects of experimental operation.

Multifrequency Raman amplifiers

DOE PAGES

Barth, Ido; Fisch, Nathaniel J.

2018-03-08

In its usual implementation, the Raman amplifier features only one pump carrier frequency. However, pulses with well-separated frequencies can also be Raman amplified while compressed in time. Amplification with frequency-separated pumps is shown to hold even in the highly nonlinear, pump-depletion regime, as derived through a fluid model, and demonstrated via particle-in-cell (PIC) simulations. The resulting efficiency is similar to single-frequency amplifiers, but, due to the beat-wave waveform of both the pump lasers and the amplified seed pulses, these amplifiers feature higher seed intensities with a shorter spike duration. Advantageously, these amplifiers also suffer less noise backscattering, because the totalmore » fluence is split between the different spectral components.« less

Multifrequency Raman amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barth, Ido; Fisch, Nathaniel J.

In its usual implementation, the Raman amplifier features only one pump carrier frequency. However, pulses with well-separated frequencies can also be Raman amplified while compressed in time. Amplification with frequency-separated pumps is shown to hold even in the highly nonlinear, pump-depletion regime, as derived through a fluid model, and demonstrated via particle-in-cell (PIC) simulations. The resulting efficiency is similar to single-frequency amplifiers, but, due to the beat-wave waveform of both the pump lasers and the amplified seed pulses, these amplifiers feature higher seed intensities with a shorter spike duration. Advantageously, these amplifiers also suffer less noise backscattering, because the totalmore » fluence is split between the different spectral components.« less

Simple two-electrode biosignal amplifier.

PubMed

Dobrev, D; Neycheva, T; Mudrov, N

2005-11-01

A simple, cost effective circuit for a two-electrode non-differential biopotential amplifier is proposed. It uses a 'virtual ground' transimpedance amplifier and a parallel RC network for input common mode current equalisation, while the signal input impedance preserves its high value. With this innovative interface circuit, a simple non-inverting amplifier fully emulates high CMRR differential. The amplifier equivalent CMRR (typical range from 70-100 dB) is equal to the open loop gain of the operational amplifier used in the transimpedance interface stage. The circuit has very simple structure and utilises a small number of popular components. The amplifier is intended for use in various two-electrode applications, such as Holter-type monitors, defibrillators, ECG monitors, biotelemetry devices etc.

Ultrasonographic evaluation of equine tendons: a quantitative in vitro study of the effects of amplifier gain level, transducer-tilt, and transducer-displacement.

PubMed

van Schie, J T; Bakker, E M; van Weeren, P R

1999-01-01

The objective of the in vitro experiments described in this paper was to quantify the effects of some instrumental variables on the quantitative evaluation, by means of first-order gray-level statistics, of ultrasonographic images of equine tendons. The experiments were done on three isolated equine superficial digital flexor tendons that were mounted in a frame and submerged in a waterbath. Sections with either normal tendon tissue, an acute lesion, or a chronic scar, were selected. In these sections, the following experiments were done: 1) a gradual increase of total amplifier gain output subdivided in 12 equal steps; 2) a transducer tilt plus or minus 3 degrees from perpendicular, with steps of 1 degree; and 3) a transducer displacement along, and perpendicular to, the tendon long axis, with 16 steps of 0.25 mm each. Transverse ultrasonographic images were collected, and in the regions of interest (ROI) first-order gray-level statistics were calculated to quantify the effects of each experiment. Some important observations were: 1) the total amplifier gain output has a substantial influence on the ultrasonographic image; for example, in the case of an acute lesion, a low gain setting results in an almost completely black image; whereas, with higher gain settings, a marked "filling in" effect on the lesion can be observed; 2) the relative effects of the tilting of the transducer are substantial in normal tendon tissue (18%) and chronic scar (12%); whereas, in the event of an acute lesion, the effects on the mean gray level are dramatic (40%); and 3) the relative effects of displacement of the transducer are small in normal tendon tissue, but on the other hand, the mean gray-level changes 7% in chronic scar, and even 20% in an acute lesion. In general, slight variations in scanner settings and transducer handling can have considerable effects on the gray levels of the ultrasonographic image. Furthermore, there is a strong indication that this quantitative method, as far as based exclusively on the first-order gray-level statistics, may be not discriminative enough to accurately assess the integrity of the tendon. Therefore, the value of a quantitative evaluation of the first-order gray-level statistics for the assessment of the integrity of the equine tendon is questionable.

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

PubMed Central

Westermann, Frank; Muth, Daniel; Benner, Axel; Bauer, Tobias; Henrich, Kai-Oliver; Oberthuer, André; Brors, Benedikt; Beissbarth, Tim; Vandesompele, Jo; Pattyn, Filip; Hero, Barbara; König, Rainer; Fischer, Matthias; Schwab, Manfred

2008-01-01

Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas, elevated MYCN mRNA and protein levels are paradoxically associated with a more favorable clinical phenotype, including disseminated tumors that subsequently regress spontaneously (stage 4s-non-amplified). In this study, we asked whether distinct transcriptional MYCN or c-MYC activities are associated with specific neuroblastoma phenotypes. Results We defined a core set of direct MYCN/c-MYC target genes by applying gene expression profiling and chromatin immunoprecipitation (ChIP, ChIP-chip) in neuroblastoma cells that allow conditional regulation of MYCN and c-MYC. Their transcript levels were analyzed in 251 primary neuroblastomas. Compared to localized-non-amplified neuroblastomas, MYCN/c-MYC target gene expression gradually increases from stage 4s-non-amplified through stage 4-non-amplified to MYCN amplified tumors. This was associated with MYCN activation in stage 4s-non-amplified and predominantly c-MYC activation in stage 4-non-amplified tumors. A defined set of MYCN/c-MYC target genes was induced in stage 4-non-amplified but not in stage 4s-non-amplified neuroblastomas. In line with this, high expression of a subset of MYCN/c-MYC target genes identifies a patient subtype with poor overall survival independent of the established risk markers amplified MYCN, disease stage, and age at diagnosis. Conclusions High MYCN/c-MYC target gene expression is a hallmark of malignant neuroblastoma progression, which is predominantly driven by c-MYC in stage 4-non-amplified tumors. In contrast, moderate MYCN function gain in stage 4s-non-amplified tumors induces only a restricted set of target genes that is still compatible with spontaneous regression. PMID:18851746

Log amplifier with pole-zero compensation

DOEpatents

Brookshier, William

1987-01-01

A logarithmic amplifier circuit provides pole-zero compensation for improved stability and response time over 6-8 decades of input signal frequency. The amplifier circuit includes a first operational amplifier with a first feedback loop which includes a second, inverting operational amplifier in a second feedback loop. The compensated output signal is provided by the second operational amplifier with the log elements, i.e., resistors, and the compensating capacitors in each of the feedback loops having equal values so that each break point or pole is offset by a compensating break point or zero.

Laser amplifier chain

DOEpatents

Hackel, R.P.

1992-10-20

A laser amplifier chain has a plurality of laser amplifiers arranged in a chain to sequentially amplify a low-power signal beam to produce a significantly higher-power output beam. Overall efficiency of such a chain is improved if high-gain, low efficiency amplifiers are placed on the upstream side of the chain where only a very small fraction of the total pumped power is received by the chain and low-gain, high-efficiency amplifiers are placed on the downstream side where a majority of pumping energy is received by the chain. 6 figs.

Project Echo: 960-Megacycle, 10-Kilowatt Transmitter

NASA Technical Reports Server (NTRS)

Schafer, J. P.; Brandt, R. H.

1961-01-01

A 10-kw transmitter operating at 960 to 961 Mc was used at the eastern terminus of the Project Echo communications experiment. This transmitter is located on Crawford's Hill near Holmdel, New Jersey. The 10-kw output feeds into a waveguide line leading to a 60-foot dish antenna. Exciter-driver units are available to drive the power amplifier with various modulations, such as wide-deviation FM, low-index phase modulation, single-sideband or double-sideband modulation with or without carrier, 960.05 or 961.05 Mc constant-frequency CW, and radar on-off pulses at 961.05 Mc. The main output amplifier consists primarily of a four-stage, externally-tuned-cavity, water-cooled klystron, operating at a beam voltage of 16 to 18 kv. The transmitter has been operated during many Moonbounce, tropospheric scatter, and Echo I tests with very satisfactory results. This paper describes its use before March 1, 1961.

Genetic relatedness of Trichoderma isolates antagonistic against Fusarium oxysporum f.sp. dianthi inflicting carnation wilt.

PubMed

Shanmugam, V; Sharma, Vivek; Ananthapadmanaban

2008-01-01

Twenty-eight isolates of Trichoderma belonging to four different species were screened in vitro for their antagonistic ability against Fusarium oxysporum f.sp. dianthi causing carnation wilt. Three different levels of antagonism observed in dual plate assay were further confirmed by cell-free culture filtrate experiments. Isolates showing class I level of antagonism produced maximum lytic enzymes, chitinases and beta-1,3-glucanases. Genetic variability of 25 selected isolates was assessed by random amplified polymorphic DNA technique and the amplified products were correlated for their level of antagonism. Unweighed pair-group method with arithmetical averages cluster analysis revealed prominent inter-and intraspecific genetic variation among the isolates. Based on their genetic relationship, the isolates were mainly distributed into 3 major groups representing T. atroviride, T. pseudokoningii and T. harzianum, with 20-35% interspecific dissimilarity. However, the polymorphism shown by the isolates did not correlate to their level of antagonism.

Gain and energy storage in holmium YLF

NASA Technical Reports Server (NTRS)

Storm, Mark E.; Deyst, John P.

1991-01-01

It is demonstrated that Q-switched holmium lasers are capable of high-gain and high-energy operation at 300 K. Small-signal gain coefficients of 0.50 and 0.12/cm have been measured in YLF and YAG, respectively. Small-signal gains of 0.50/cm are comparable to those achievable in Nd:YAG and are not typical of low-gain materials. This large gain in the Ho:YLF material is made possible by operating the amplifier in the ground state depletion mode. The amplifier performance data and associated analysis presented demonstrate that efficient energy storage is possible with very high excited state ion densities of the Ho 5I7 upper laser level. This is an important result since upconversion can limit the 5I7 population. Although upconversion was still present in this experiment, it was possible to achieve efficient energy storage, demonstrating that the problem is manageable even at high excitation densities in YLF.

A Low Noise Amplifier for Neural Spike Recording Interfaces

PubMed Central

Ruiz-Amaya, Jesus; Rodriguez-Perez, Alberto; Delgado-Restituto, Manuel

2015-01-01

This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 μVrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz–7.4 kHz and consumes 1.92 μW. The performance of the proposed LNA has been validated through in vivo experiments with animal models. PMID:26437411

A Low Noise Amplifier for Neural Spike Recording Interfaces.

PubMed

Ruiz-Amaya, Jesus; Rodriguez-Perez, Alberto; Delgado-Restituto, Manuel

2015-09-30

This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 μVrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz-7.4 kHz and consumes 1.92 μW. The performance of the proposed LNA has been validated through in vivo experiments with animal models.

Beam combining and SBS suppression in white noise and pseudo-random modulated amplifiers

NASA Astrophysics Data System (ADS)

Anderson, Brian; Flores, Angel; Holten, Roger; Ehrenreich, Thomas; Dajani, Iyad

2015-03-01

White noise phase modulation (WNS) and pseudo-random binary sequence phase modulation (PRBS) are effective techniques for mitigation of nonlinear effects such as stimulated Brillouin scattering (SBS); thereby paving the way for higher power narrow linewidth fiber amplifiers. However, detailed studies comparing both coherent beam combination and the SBS suppression of these phase modulation schemes have not been reported. In this study an active fiber cutback experiment is performed comparing the enhancement factor of a PRBS and WNS broadened seed as a function of linewidth and fiber length. Furthermore, two WNS and PRBS modulated fiber lasers are coherently combined to measure and compare the fringe visibility and coherence length as a function of optical path length difference. Notably, the discrete frequency comb of PRBS modulation provides a beam combining re-coherence effect where the lasers periodically come back into phase. Significantly, this may reduce path length matching complexity in coherently combined fiber laser systems.

Two-color pump-probe laser spectroscopy instrument with picosecond time-resolved electronic delay and extended scan range

NASA Astrophysics Data System (ADS)

Yu, Anchi; Ye, Xiong; Ionascu, Dan; Cao, Wenxiang; Champion, Paul M.

2005-11-01

An electronically delayed two-color pump-probe instrument was developed using two synchronized laser systems. The instrument has picosecond time resolution and can perform scans over hundreds of nanoseconds without the beam divergence and walk-off effects that occur using standard spatial delay systems. A unique picosecond Ti :sapphire regenerative amplifier was also constructed without the need for pulse stretching and compressing optics. The picosecond regenerative amplifier has a broad wavelength tuning range, which suggests that it will make a significant contribution to two-color pump-probe experiments. To test this instrument we studied the rotational correlation relaxation of myoglobin (τr=8.2±0.5ns) in water as well as the geminate rebinding kinetics of oxygen to myoglobin (kg1=1.7×1011s-1, kg2=3.4×107s-1). The results are consistent with, and improve upon, previous studies.

SiC MOSFET Switching Power Amplifier Project Summary

NASA Astrophysics Data System (ADS)

Miller, Kenneth E.; Ziemba, Timothy; Prager, James; Slobodov, Ilia; Henson, Alex

2017-10-01

Eagle Harbor Technologies has completed a Phase I/II program to develop SiC MOSFET based Switching Power Amplifiers (SPA) for precision magnet control in fusion science applications. During this program, EHT developed several units have been delivered to the Helicity Injected Torus (HIT) experiment at the University of Washington to drive both the voltage and flux circuits of the helicity injectors. These units are capable of switching 700 V at 100 kHz with an adjustable duty cycle from 10 - 90% and a combined total output current of 96 kA for 4 ms (at max current). The SPAs switching is controlled by the microcontroller at HIT, which adjusts the duty cycle to maintain a specific waveform in the injector. The SPAs include overcurrent and shoot-through protection circuity. EHT will present an overview of the program including final results for the SPA waveforms. With support of DOE SBIR.

LabPatch, an acquisition and analysis program for patch-clamp electrophysiology.

PubMed

Robinson, T; Thomsen, L; Huizinga, J D

2000-05-01

An acquisition and analysis program, "LabPatch," has been developed for use in patch-clamp research. LabPatch controls any patch-clamp amplifier, acquires and records data, runs voltage protocols, plots and analyzes data, and connects to spreadsheet and database programs. Controls within LabPatch are grouped by function on one screen, much like an oscilloscope front panel. The software is mouse driven, so that the user need only point and click. Finally, the ability to copy data to other programs running in Windows 95/98, and the ability to keep track of experiments using a database, make LabPatch extremely versatile. The system requirements include Windows 95/98, at least a 100-MHz processor and 16 MB RAM, a data acquisition card, digital-to-analog converter, and a patch-clamp amplifier. LabPatch is available free of charge at http://www.fhs.mcmaster.ca/huizinga/.

Lactobacillus nantensis sp. nov., isolated from French wheat sourdough.

PubMed

Valcheva, Rosica; Ferchichi, Mounir F; Korakli, Maher; Ivanova, Iskra; Gänzle, Michael G; Vogel, Rudi F; Prévost, Hervé; Onno, Bernard; Dousset, Xavier

2006-03-01

A polyphasic taxonomic study of the bacterial flora isolated from traditional French wheat sourdough, using phenotypic characterization and phylogenetic as well as genetic methods, revealed a consistent group of isolates that could not be assigned to any recognized species. These results were confirmed by randomly amplified polymorphic DNA and amplified fragment length polymorphism fingerprinting analyses. Cells were Gram-positive, homofermentative rods. Comparative 16S rRNA gene sequence analysis of the representative strain LP33T indicated that these strains belong to the genus Lactobacillus and that they formed a branch distinct from their closest relatives Lactobacillus farciminis, Lactobacillus alimentarius, Lactobacillus paralimentarius and Lactobacillus mindensis. DNA-DNA reassociation experiments with the three phylogenetically closest Lactobacillus species confirmed that LP33T (= DSM 16982T = CIP 108546T = TMW 1.1265T) represents the type strain of a novel species, for which the name Lactobacillus nantensis sp. nov. is proposed.

Noise and linearity optimization methods for a 1.9GHz low noise amplifier.

PubMed

Guo, Wei; Huang, Da-Quan

2003-01-01

Noise and linearity performances are critical characteristics for radio frequency integrated circuits (RFICs), especially for low noise amplifiers (LNAs). In this paper, a detailed analysis of noise and linearity for the cascode architecture, a widely used circuit structure in LNA designs, is presented. The noise and the linearity improvement techniques for cascode structures are also developed and have been proven by computer simulating experiments. Theoretical analysis and simulation results showed that, for cascode structure LNAs, the first metallic oxide semiconductor field effect transistor (MOSFET) dominates the noise performance of the LNA, while the second MOSFET contributes more to the linearity. A conclusion is thus obtained that the first and second MOSFET of the LNA can be designed to optimize the noise performance and the linearity performance separately, without trade-offs. The 1.9GHz Complementary Metal-Oxide-Semiconductor (CMOS) LNA simulation results are also given as an application of the developed theory.

DOE Office of Scientific and Technical Information (OSTI.GOV)

ANDONIAN,G.BABZIEN,MLBEN-ZVI,I.YAKIMENKO,Y.ET AL.

VISA II is the follow-up project to the successful Visible to Infrared SASE Amplifier (VISA) experiment at the Accelerator Test Facility (ATF) in Brookhaven National Lab (BNL). This paper will report the motivation for and status of the two main experiments associated with the VISA II program. One goal of VISA II is to perform an experimental study of the physics of a chirped beam SASE FEL at the upgraded facilities of the ATF. This requires a linearization of the transport line to preserve energy chirping of the electron beam at injection. The other planned project is a strong bunchmore » compression experiment, where the electron bunch is compressed in the chicane, and the dispersive beamline transport, allowing studies of deep saturation.« less

Amplifiers in the radio-electronic equipment of aircraft

NASA Astrophysics Data System (ADS)

Khol'Nyi, Vladimir Ia.

The applications, classification, and technical specifications of airborne electronic amplifiers are discussed. Particular attention is given to the general design and principles of operation of single amplification cascades and multicascade amplifiers, including dc, audio, and video amplifiers used as part of the radio-electronic equipment of modern aircraft. The discussion also covers the principal technical and performance characteristics of various amplifiers, their operating conditions, service, and repair.

Is This Op-Amp Any Good?: Lab-Built Checker Removes All Doubt!

ERIC Educational Resources Information Center

Harman, Charles

2007-01-01

Electronics instructors and students find it very helpful to be able to check an operational amplifier at the proto-board stage. Most students lack the experience or knowledge that it takes to recognize whether an op-amp is operating normally or not. This article discusses a handy op-amp checker that allows one to check and/or test op-amps at the…

Femtosecond Amplifiers and Microlasers in the Deep Ultraviolet

DTIC Science & Technology

2013-11-19

Laser guide stars have applications of growing importance to the DOD, astronomy, and environmental monitoring. However, realizing a laser that is...pump wavelength, photoassociation-pumped lasers hold considerable promise as guide star lasers . The most exciting aspect of these results, however...highlights of several experiments that were mentioned briefly in the last section. A. Dual Wavelength Sodium Laser Pumped By Na-Xe Pair Absorption

Contemplating the GANE model using an extreme case paradigm.

PubMed

Geva, Ronny

2016-01-01

Early experiences play a crucial role in programming brain function, affecting selective attention, learning, and memory. Infancy literature suggests an extension of the GANE (glutamate amplifies noradrenergic effects) model to conditions with minimal priority-map inputs, yet suggests qualifications by noting that its efficacy is increased when tonic levels of arousal are maintained in an optimal range, in manners that are age and exposure dependent.

Laser Development for Interferometry in Space

NASA Technical Reports Server (NTRS)

Numata, Kenji; Camp, Jordan

2012-01-01

We are developing a laser (master oscillator) and optical amplifier for interferometric space missions, including the gravitational-wave missions NGO and OpTIIX experiment on the international space station. Our system is based on optical fiber and semiconductor laser technologies, which have evolved dramatically in the past decade. We will report on the latest status of the development work, including noise measurements and space qualification tests.

Balancing Considerations of Equity, Content Quality, and Technical Excellence in Designing, Validating and Implementing Performance Assessments in the Context of Mathematics Instructional Reform: The Experience of the QUASAR Project.

ERIC Educational Resources Information Center

Silver, Edward A.; Lane, Suzanne

Issues of educational equity and quality are explored in the context of the Quantitative Understanding: Amplifying Student Achievement and Reasoning (QUASAR) project, a national educational reform project aimed at fostering and studying the development and implementation of enhanced mathematics instructional programs for students attending middle…

Electronics for a focal plane crystal spectrometer

NASA Technical Reports Server (NTRS)

Goeke, R. F.

1978-01-01

The HEAO-B program forced the usual constraints upon the spacecraft experiment electronics: high reliability, low power consumption, and tight packaging at reasonable cost. The programmable high voltage power supplies were unique in both application and simplicity of manufacture. The hybridized measurement chain is a modification of that used on the SAS-C program; the charge amplifier design in particular shows definite improvement in performance over previous work.

Multistaged stokes injected Raman capillary waveguide amplifier

DOEpatents

Kurnit, Norman A.

1980-01-01

A multistaged Stokes injected Raman capillary waveguide amplifier for providing a high gain Stokes output signal. The amplifier uses a plurality of optically coupled capillary waveguide amplifiers and one or more regenerative amplifiers to increase Stokes gain to a level sufficient for power amplification. Power amplification is provided by a multifocused Raman gain cell or a large diameter capillary waveguide. An external source of CO.sub.2 laser radiation can be injected into each of the capillary waveguide amplifier stages to increase Raman gain. Devices for injecting external sources of CO.sub.2 radiation include: dichroic mirrors, prisms, gratings and Ge Brewster plates. Alternatively, the CO.sub.2 input radiation to the first stage can be coupled and amplified between successive stages.

Note: Development of a wideband amplifier for cryogenic scanning tunneling microscopy.

PubMed

Zhang, Chao; Jeon, Hoyeon; Oh, Myungchul; Lee, Minjun; Kim, Sungmin; Yi, Sunwouk; Lee, Hanho; Zoh, Inhae; Yoo, Yongchan; Kuk, Young

2017-06-01

A wideband cryogenic amplifier has been developed for low temperature scanning tunneling microscopy. The amplifier consisting of a wideband complementary metal oxide semiconductor field effect transistors operational amplifier together with a feedback resistor of 100 kΩ and a capacitor is mounted within a 4 K Dewar. This amplifier has a wide bandwidth and is successfully applied to scanning tunneling microscopy applications at low temperatures down to ∼7 K. The quality of the designed amplifier is validated by high resolution imaging. More importantly, the amplifier has also proved to be capable of performing scanning tunneling spectroscopy measurements, showing the detection of the Shockley surface state of the Au(111) surface and the superconducting gap of Nb(110).

Note: Development of a wideband amplifier for cryogenic scanning tunneling microscopy

NASA Astrophysics Data System (ADS)

Zhang, Chao; Jeon, Hoyeon; Oh, Myungchul; Lee, Minjun; Kim, Sungmin; Yi, Sunwouk; Lee, Hanho; Zoh, Inhae; Yoo, Yongchan; Kuk, Young

2017-06-01

A wideband cryogenic amplifier has been developed for low temperature scanning tunneling microscopy. The amplifier consisting of a wideband complementary metal oxide semiconductor field effect transistors operational amplifier together with a feedback resistor of 100 kΩ and a capacitor is mounted within a 4 K Dewar. This amplifier has a wide bandwidth and is successfully applied to scanning tunneling microscopy applications at low temperatures down to ˜7 K. The quality of the designed amplifier is validated by high resolution imaging. More importantly, the amplifier has also proved to be capable of performing scanning tunneling spectroscopy measurements, showing the detection of the Shockley surface state of the Au(111) surface and the superconducting gap of Nb(110).

High-efficiency solid state power amplifier

NASA Technical Reports Server (NTRS)

Wallis, Robert E. (Inventor); Cheng, Sheng (Inventor)

2005-01-01

A high-efficiency solid state power amplifier (SSPA) for specific use in a spacecraft is provided. The SSPA has a mass of less than 850 g and includes two different X-band power amplifier sections, i.e., a lumped power amplifier with a single 11-W output and a distributed power amplifier with eight 2.75-W outputs. These two amplifier sections provide output power that is scalable from 11 to 15 watts without major design changes. Five different hybrid microcircuits, including high-efficiency Heterostructure Field Effect Transistor (HFET) amplifiers and Monolithic Microwave Integrated Circuit (MMIC) phase shifters have been developed for use within the SSPA. A highly efficient packaging approach enables the integration of a large number of hybrid circuits into the SSPA.

Ferroelectric Field-Effect Transistor Differential Amplifier Circuit Analysis

NASA Technical Reports Server (NTRS)

Phillips, Thomas A.; MacLeod, Todd C.; Ho, Fat D.

2008-01-01

There has been considerable research investigating the Ferroelectric Field-Effect Transistor (FeFET) in memory circuits. However, very little research has been performed in applying the FeFET to analog circuits. This paper investigates the use of FeFETs in a common analog circuit, the differential amplifier. The two input Metal-Oxide-Semiconductor (MOS) transistors in a general MOS differential amplifier circuit are replaced with FeFETs. Resistors are used in place of the other three MOS transistors. The FeFET model used in the analysis has been previously reported and was based on experimental device data. Because of the FeFET hysteresis, the FeFET differential amplifier has four different operating modes depending on whether the FeFETs are positively or negatively polarized. The FeFET differential amplifier operation in the different modes was analyzed by calculating the amplifier voltage transfer and gain characteristics shown in figures 2 through 5. Comparisons were made between the FeFET differential amplifier and the standard MOS differential amplifier. Possible applications and benefits of the FeFET differential amplifier are discussed.

Automatic alignment of double optical paths in excimer laser amplifier

NASA Astrophysics Data System (ADS)

Wang, Dahui; Zhao, Xueqing; Hua, Hengqi; Zhang, Yongsheng; Hu, Yun; Yi, Aiping; Zhao, Jun

2013-05-01

A kind of beam automatic alignment method used for double paths amplification in the electron pumped excimer laser system is demonstrated. In this way, the beams from the amplifiers can be transferred along the designated direction and accordingly irradiate on the target with high stabilization and accuracy. However, owing to nonexistence of natural alignment references in excimer laser amplifiers, two cross-hairs structure is used to align the beams. Here, one crosshair put into the input beam is regarded as the near-field reference while the other put into output beam is regarded as the far-field reference. The two cross-hairs are transmitted onto Charge Coupled Devices (CCD) by image-relaying structures separately. The errors between intersection points of two cross-talk images and centroid coordinates of actual beam are recorded automatically and sent to closed loop feedback control mechanism. Negative feedback keeps running until preset accuracy is reached. On the basis of above-mentioned design, the alignment optical path is built and the software is compiled, whereafter the experiment of double paths automatic alignment in electron pumped excimer laser amplifier is carried through. Meanwhile, the related influencing factors and the alignment precision are analyzed. Experimental results indicate that the alignment system can achieve the aiming direction of automatic aligning beams in short time. The analysis shows that the accuracy of alignment system is 0.63μrad and the beam maximum restoration error is 13.75μm. Furthermore, the bigger distance between the two cross-hairs, the higher precision of the system is. Therefore, the automatic alignment system has been used in angular multiplexing excimer Main Oscillation Power Amplification (MOPA) system and can satisfy the requirement of beam alignment precision on the whole.

Mercury heavy-metal-induced physiochemical changes and genotoxic alterations in water hyacinths [Eichhornia crassipes (Mart.)].

PubMed

Malar, Srinivasan; Sahi, Shivendra Vikram; Favas, Paulo J C; Venkatachalam, Perumal

2015-03-01

Mercury heavy metal pollution has become an important environmental problem worldwide. Accumulation of mercury ions by plants may disrupt many cellular functions and block normal growth and development. To assess mercury heavy metal toxicity, we performed an experiment focusing on the responses of Eichhornia crassipes to mercury-induced oxidative stress. E. crassipes seedlings were exposed to varying concentrations of mercury to investigate the level of mercury ions accumulation, changes in growth patterns, antioxidant defense mechanisms, and DNA damage under hydroponics system. Results showed that plant growth rate was significantly inhibited (52 %) at 50 mg/L treatment. Accumulation of mercury ion level were 1.99 mg/g dry weight, 1.74 mg/g dry weight, and 1.39 mg/g dry weight in root, leaf, and petiole tissues, respectively. There was a decreasing trend for chlorophyll a, b, and carotenoids with increasing the concentration of mercury ions. Both the ascorbate peroxidase and malondialdehyde contents showed increased trend in leaves and roots up to 30 mg/L mercury treatment and slightly decreased at the higher concentrations. There was a positive correlation between heavy metal dose and superoxide dismutase, catalase, and peroxidase antioxidative enzyme activities which could be used as biomarkers to monitor pollution in E. crassipes. Due to heavy metal stress, some of the normal DNA bands were disappeared and additional bands were amplified compared to the control in the random amplified polymorphic DNA (RAPD) profile. Random amplified polymorphic DNA results indicated that genomic template stability was significantly affected by mercury heavy metal treatment. We concluded that DNA changes determined by random amplified polymorphic DNA assay evolved a useful molecular marker for detection of genotoxic effects of mercury heavy metal contamination in plant species.

Efficient Ultra-High Speed Communication with Simultaneous Phase and Amplitude Regenerative Sampling (SPARS)

NASA Astrophysics Data System (ADS)

Carlowitz, Christian; Girg, Thomas; Ghaleb, Hatem; Du, Xuan-Quang

2017-09-01

For ultra-high speed communication systems at high center frequencies above 100 GHz, we propose a disruptive change in system architecture to address major issues regarding amplifier chains with a large number of amplifier stages. They cause a high noise figure and high power consumption when operating close to the frequency limits of the underlying semiconductor technologies. Instead of scaling a classic homodyne transceiver system, we employ repeated amplification in single-stage amplifiers through positive feedback as well as synthesizer-free self-mixing demodulation at the receiver to simplify the system architecture notably. Since the amplitude and phase information for the emerging oscillation is defined by the input signal and the oscillator is only turned on for a very short time, it can be left unstabilized and thus come without a PLL. As soon as gain is no longer the most prominent issue, relaxed requirements for all the other major components allow reconsidering their implementation concepts to achieve further improvements compared to classic systems. This paper provides the first comprehensive overview of all major design aspects that need to be addressed upon realizing a SPARS-based transceiver. At system level, we show how to achieve high data rates and a noise performance comparable to classic systems, backed by scaled demonstrator experiments. Regarding the transmitter, design considerations for efficient quadrature modulation are discussed. For the frontend components that replace PA and LNA amplifier chains, implementation techniques for regenerative sampling circuits based on super-regenerative oscillators are presented. Finally, an analog-to-digital converter with outstanding performance and complete interfaces both to the analog baseband as well as to the digital side completes the set of building blocks for efficient ultra-high speed communication.

Automatic quadrature control and measuring system

NASA Technical Reports Server (NTRS)

Hamlet, J. F.

1973-01-01

Quadrature is separated from amplified signal by use of phase detector, with phase shifter providing appropriate reference. Output of phase detector is further amplified and filtered by dc amplifier. Output of dc amplifier provides signal to neutralize quadrature component of transducer signal.

Measurements of the Low Frequency Gain Fluctuations of a 30 GHz High-Electron-Mobility-Transistor Cryogenic Amplifier

NASA Technical Reports Server (NTRS)

Jarosik, Norman

1994-01-01

Low frequency gain fluctuations of a 30 GHz cryogenic HEMT amplifier have been measured with the input of the amplifier connected to a 15 K load. Effects of fluctuations of other components of the test set-up were eliminated by use of a power-power correlation technique. Strong correlation between output power fluctuations of the amplifier and drain current fluctuations of the transistors comprising the amplifier are observed. The existence of these correlations introduces the possibility of regressing some of the excess noise from the HEMT amplifier's output using the measured drain currents.

Experimental industrial signal acquisition board in a large scientific device

NASA Astrophysics Data System (ADS)

Zeng, Xiangzhen; Ren, Bin

2018-02-01

In order to measure the industrial signal of neutrino experiment, a set of general-purpose industrial data acquisition board has been designed. It includes the function of switch signal input and output, and the function of analog signal input. The main components are signal isolation amplifier and filter circuit, ADC circuit, microcomputer systems and isolated communication interface circuit. Through the practical experiments, it shows that the system is flexible, reliable, convenient and economical, and the system has characters of high definition and strong anti-interference ability. Thus, the system fully meets the design requirements.

A straw chambers' tracker for the high rate experiment 835 at the Fermilab accumulator

NASA Astrophysics Data System (ADS)

Bagnasco, S.; Dughera, G.; Giraudo, G.; Govi, G.; Marchetto, F.; Menichetti, E.; Pastrone, N.; Rumerio, P.; Trapani, P. P.

1998-02-01

Two layers of proportional drift tubes (aluminum mylar straws) are staggered in two cylindrical light chambers to measure charged particles' azimuthal angle. To stand the high rates (˜10 kHz/ cm2) and minimize the pile-up of the high luminosity experiment 835 at FNAL, a fast ASIC Amplifier-Shaper-Discriminator (ASD-8B) was chosen. The front-end electronics, designed exclusively with SMD components, was mounted on the downstream end plug of each chamber to avoid oscillations and noise. Design, construction and operational performances of these detectors are presented.

KSC-2009-1086

NASA Image and Video Library

2009-01-09

CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, the ICS Exposed Facility, or ICS-EF, is lifted from its stand. It will be installed on the Japanese Experiment Module's Experiment Logistics Module-Exposed Section, or ELM-ES. The ICS-EF is composed of several components, including an antenna, pointing mechanism, frequency converters, high-power amplifier and various sensors including the Earth sensor, Sun sensor and inertial reference unit. The ICS-EF is part of space shuttle Endeavour's payload on the STS-127 mission, targeted for launch on May 15. Photo credit: NASA/Jim Grossmann

KSC-2009-1087

NASA Image and Video Library

2009-01-09

CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, workers examine the ICS Exposed Facility, or ICS-EF, after it is lifted from its stand. It will be installed on the Japanese Experiment Module's Experiment Logistics Module-Exposed Section, or ELM-ES. The ICS-EF is composed of several components, including an antenna, pointing mechanism, frequency converters, high-power amplifier and various sensors including the Earth sensor, Sun sensor and inertial reference unit. The ICS-EF is part of space shuttle Endeavour's payload on the STS-127 mission, targeted for launch on May 15. Photo credit: NASA/Jim Grossmann

[Thought Experiments of Economic Surplus: Science and Economy in Ernst Mach's Epistemology].

PubMed

Wulz, Monika

2015-03-01

Thought Experiments of Economic Surplus: Science and Economy in Ernst Mach's Epistemology. Thought experiments are an important element in Ernst Mach's epistemology: They facilitate amplifying our knowledge by experimenting with thoughts; they thus exceed the empirical experience and suspend the quest for immediate utility. In an economical perspective, Mach suggested that thought experiments depended on the production of an economic surplus based on the division of labor relieving the struggle for survival of the individual. Thus, as frequently emphasized, in Mach's epistemology, not only the 'economy of thought' is an important feature; instead, also the socioeconomic conditions of science play a decisive role. The paper discusses the mental and social economic aspects of experimental thinking in Mach's epistemology and examines those within the contemporary evolutionary, physiological, and economic contexts. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

When sex is more than just sex: attachment orientations, sexual experience, and relationship quality.

PubMed

Birnbaum, Gurit E; Reis, Harry T; Mikulincer, Mario; Gillath, Omri; Orpaz, Ayala

2006-11-01

The authors explored the contribution of individual differences in attachment orientations to the experience of sexual intercourse and its association with relationship quality. In Study 1, 500 participants completed self-report scales of attachment orientations and sexual experience. The findings indicated that whereas attachment anxiety was associated with an ambivalent construal of sexual experience, attachment avoidance was associated with more aversive sexual feelings and cognitions. In Study 2, 41 couples reported on their attachment orientations and provided daily diary measures of sexual experiences and relationship interactions for a period of 42 days. Results showed that attachment anxiety amplified the effects of positive and negative sexual experiences on relationship interactions. In contrast, attachment avoidance inhibited the positive relational effect of having sex and the detrimental relational effects of negative sexual interactions. The authors discuss the possibility that attachment orientations are associated with different sex-related strategies and goals within romantic relationships.

Bio-isolated DC operational amplifier

NASA Technical Reports Server (NTRS)

Lee, R. D.

1974-01-01

Possibility of shocks from leakage currents can be reduced by use of isolated preamplifiers. Amplifier consists of battery-powered operational amplifier coupled by means of light-emitting diodes to another amplifier which may be grounded and operated from ac power mains or separate battery supply.

Angle amplifier based on multiplexed volume holographic gratings

NASA Astrophysics Data System (ADS)

Cao, Liangcai; Zhao, Yifei; He, Qingsheng; Jin, Guofan

2008-03-01

Angle amplifier of laser beam scanner is a widely used device in optical systems. Volume holographic optical elements can be applied in the angle amplifier. Compared with the traditional angle amplifier, it has the advantages of high angle resolution, high diffraction efficiency, small size, and high angle magnification and flexible design. Bragg anglewavelength- compensating recording method is introduced. Because of the Bragg compensatory relation between angle and wavelength, this device could be recorded at another wavelength. The design of the angle amplifier recording at the wavelength of 514.2nm for the working wavelength of 632.8nm is described. An optical setup for recording the angle amplifier device is designed and discussed. Experimental results in the photorefractive crystal Fe:LiNbO 3 demonstrate the feasibility of the angle amplifier scheme.

Controlling the 1 μm spontaneous emission in Er/Yb co-doped fiber amplifiers.

PubMed

Sobon, Grzegorz; Kaczmarek, Pawel; Antonczak, Arkadiusz; Sotor, Jaroslaw; Abramski, Krzysztof M

2011-09-26

In this paper we present our experimental studies on controlling the amplified spontaneous emission (ASE) from Yb(3+) ions in Er/Yb co-doped fiber amplifiers. We propose a new method of controlling the Yb-ASE by stimulating a laser emission at 1064 nm in the amplifier, by providing a positive 1 μm signal feedback loop. The results are discussed and compared to a conventional amplifier setup without 1 μm ASE control and to an amplifier with auxiliary 1064 nm seeding. We have shown, that applying a 1064 nm signal loop in an Er/Yb amplifier can increase the output power at 1550 nm and provide stable operation without parasitic lasing at 1 μm. © 2011 Optical Society of America

LOGARITHMIC AMPLIFIER

DOEpatents

De Shong, J.A. Jr.

1957-12-31

A logarithmic current amplifier circuit having a high sensitivity and fast response is described. The inventor discovered the time constant of the input circuit of a system utilizing a feedback amplifier, ionization chamber, and a diode, is inversely proportional to the input current, and that the amplifier becomes unstable in amplifying signals in the upper frequency range when the amplifier's forward gain time constant equals the input circuit time constant. The described device incorporates impedance networks having low frequency response characteristic at various points in the circuit to change the forward gain of the amplifler at a rate of 0.7 of the gain magnitude for every two times increased in frequency. As a result of this improvement, the time constant of the input circuit is greatly reduced at high frequencies, and the amplifier response is increased.

Advancing Translational Space Research Through Biospecimen Sharing: Amplified Impact of Studies Utilizing Analogue Space Platforms

NASA Technical Reports Server (NTRS)

Staten, B.; Moyer, E.; Vizir, V.; Gompf, H.; Hoban-Higgins, T.; Lewis, L.; Ronca, A.; Fuller, C. A.

2016-01-01

Biospecimen Sharing Programs (BSPs) have been organized by NASA Ames Research Center since the 1960s with the goal of maximizing utilization and scientific return from rare, complex and costly spaceflight experiments. BSPs involve acquiring otherwise unused biological specimens from primary space research experiments for distribution to secondary experiments. Here we describe a collaboration leveraging Ames expertise in biospecimen sharing to magnify the scientific impact of research informing astronaut health funded by the NASA Human Research Program (HRP) Human Health Countermeasures (HHC) Element. The concept expands biospecimen sharing to one-off ground-based studies utilizing analogue space platforms (e.g., Hindlimb Unloading (HLU), Artificial Gravity) for rodent experiments, thereby significantly broadening the range of research opportunities with translational relevance for protecting human health in space and on Earth.

X-Band, 17-Watt Solid-State Power Amplifier

NASA Technical Reports Server (NTRS)

Mittskus, Anthony; Stone, Ernest; Boger, William; Burgess, David; Honda, Richard; Nuckolls, Carl

2005-01-01

An advanced solid-state power amplifier that can generate an output power of as much as 17 W at a design operating frequency of 8.4 GHz has been designed and constructed as a smaller, lighter, less expensive alternative to traveling-wave-tube X-band amplifiers and to prior solid-state X-band power amplifiers of equivalent output power. This amplifier comprises a monolithic microwave integrated circuit (MMIC) amplifier module and a power-converter module integrated into a compact package (see Figure 1). The amplifier module contains an input variable-gain amplifier (VGA), an intermediate driver stage, a final power stage, and input and output power monitors (see Figure 2). The VGA and the driver amplifier are 0.5-m GaAs-based metal semiconductor field-effect transistors (MESFETs). The final power stage contains four parallel high-efficiency, GaAs-based pseudomorphic high-electron-mobility transistors (PHEMTs). The gain of the VGA is voltage-variable over a range of 10 to 24 dB. To provide for temperature compensation of the overall amplifier gain, the gain-control voltage is generated by an operational-amplifier circuit that includes a resistor/thermistor temperature-sensing network. The driver amplifier provides a gain of 14 dB to an output power of 27 dBm to drive the four parallel output PHEMTs, each of which is nominally capable of putting out as much as 5 W. The driver output is sent to the input terminals of the four parallel PHEMTs through microstrip power dividers; the outputs of these PHEMTs are combined by microstrip power combiners (which are similar to the microstrip power dividers) to obtain the final output power of 17 W.

Bias-Voltage Stabilizer for HVHF Amplifiers in VHF Pulse-Echo Measurement Systems.

PubMed

Choi, Hojong; Park, Chulwoo; Kim, Jungsuk; Jung, Hayong

2017-10-23

The impact of high-voltage-high-frequency (HVHF) amplifiers on echo-signal quality is greater with very-high-frequency (VHF, ≥100 MHz) ultrasound transducers than with low-frequency (LF, ≤15 MHz) ultrasound transducers. Hence, the bias voltage of an HVHF amplifier must be stabilized to ensure stable echo-signal amplitudes. We propose a bias-voltage stabilizer circuit to maintain stable DC voltages over a wide input range, thus reducing the harmonic-distortion components of the echo signals in VHF pulse-echo measurement systems. To confirm the feasibility of the bias-voltage stabilizer, we measured and compared the deviations in the gain of the HVHF amplifier with and without a bias-voltage stabilizer. Between -13 and 26 dBm, the measured gain deviations of a HVHF amplifier with a bias-voltage stabilizer are less than that of an amplifier without a bias-voltage stabilizer. In order to confirm the feasibility of the bias-voltage stabilizer, we compared the pulse-echo responses of the amplifiers, which are typically used for the evaluation of transducers or electronic components used in pulse-echo measurement systems. From the responses, we observed that the amplitudes of the echo signals of a VHF transducer triggered by the HVHF amplifier with a bias-voltage stabilizer were higher than those of the transducer triggered by the HVHF amplifier alone. The second, third, and fourth harmonic-distortion components of the HVHF amplifier with the bias-voltage stabilizer were also lower than those of the HVHF amplifier alone. Hence, the proposed scheme is a promising method for stabilizing the bias voltage of an HVHF amplifier, and improving the echo-signal quality of VHF transducers.

Bias-Voltage Stabilizer for HVHF Amplifiers in VHF Pulse-Echo Measurement Systems

PubMed Central

Choi, Hojong; Park, Chulwoo; Kim, Jungsuk; Jung, Hayong

2017-01-01

The impact of high-voltage–high-frequency (HVHF) amplifiers on echo-signal quality is greater with very-high-frequency (VHF, ≥100 MHz) ultrasound transducers than with low-frequency (LF, ≤15 MHz) ultrasound transducers. Hence, the bias voltage of an HVHF amplifier must be stabilized to ensure stable echo-signal amplitudes. We propose a bias-voltage stabilizer circuit to maintain stable DC voltages over a wide input range, thus reducing the harmonic-distortion components of the echo signals in VHF pulse-echo measurement systems. To confirm the feasibility of the bias-voltage stabilizer, we measured and compared the deviations in the gain of the HVHF amplifier with and without a bias-voltage stabilizer. Between −13 and 26 dBm, the measured gain deviations of a HVHF amplifier with a bias-voltage stabilizer are less than that of an amplifier without a bias-voltage stabilizer. In order to confirm the feasibility of the bias-voltage stabilizer, we compared the pulse-echo responses of the amplifiers, which are typically used for the evaluation of transducers or electronic components used in pulse-echo measurement systems. From the responses, we observed that the amplitudes of the echo signals of a VHF transducer triggered by the HVHF amplifier with a bias-voltage stabilizer were higher than those of the transducer triggered by the HVHF amplifier alone. The second, third, and fourth harmonic-distortion components of the HVHF amplifier with the bias-voltage stabilizer were also lower than those of the HVHF amplifier alone. Hence, the proposed scheme is a promising method for stabilizing the bias voltage of an HVHF amplifier, and improving the echo-signal quality of VHF transducers. PMID:29065526

Two and Three Beam Pumped Optical Parametric Amplifier of Chirped Pulses

NASA Astrophysics Data System (ADS)

Ališauskas, S.; Butkus, R.; Pyragaitė, V.; Smilgevičius, V.; Stabinis, A.; Piskarskas, A.

2010-04-01

We present two and three beam pumped optical parametric amplifier of broadband chirped pulses. The seed pulses from Ti:sapphire oscillator were stretched and amplified in a non-collinear geometry pumping with up to three beams derived from independent laser amplifiers. The signal with ˜90 nm bandwidth was amplified up to 0.72 mJ. The conversion efficiency dependence on intersection angles of pump beams is also revealed.

Development of a High-Power Wideband Amplifier on the Basis of a Free-Electron Maser Having an Operating Frequency Near 30 GHz: Modeling and Results of the Initial Experiments

NASA Astrophysics Data System (ADS)

Bandurkin, I. V.; Donets, D. E.; Kaminsky, A. K.; Kuzikov, S. V.; Perel'shteyn, E. A.; Peskov, N. Yu.; Savilov, A. V.; Sedykh, S. N.

2017-01-01

We develop a high-power wideband amplifier based on a free-electron maser for particle acceleration, which will be operated in the 30 GHz frequency band, on the basis of the LIU-3000 linear induction accelerator forming an electron beam with an electron energy of 0.8 MeV, a current of 250 A, and a pulse duration of 200 ns. As the operating regime, we chose the regime of grazing of dispersion curves, since, according to the modeling performed, it allows one to ensure an instantaneous amplification band of about 5-7% in an undulator with regular winding for an output radiation power at a level of 20 MW and a gain of 30-35 dB. The results of the first experiments studying this FEM-based scheme are presented, in which the specified power level is achieved in the range around 30 GHz, and fast tuning of ±0.5 GHz in the band of variations in the frequency of the master magnetron is demonstrated. Modeling shows that the use of the non-resonance trapping/braking regime, which is realized in an undulator with profiled parameters, allows one to expect an increase in the radiation power of up to 35-40 MW with simultaneous widening of the amplification band up to 30% under the conditions of the LIU-3000 experiments.

Meter circuit for tuning RF amplifiers

NASA Technical Reports Server (NTRS)

Longthorne, J. E.

1973-01-01

Circuit computes and indicates efficiency of RF amplifier as inputs and other parameters are varied. Voltage drop across internal resistance of ammeter is amplified by operational amplifier and applied to one multiplier input. Other input is obtained through two resistors from positive terminal of power supply.

High-gain cryogenic amplifier assembly employing a commercial CMOS operational amplifier.

PubMed

Proctor, J E; Smith, A W; Jung, T M; Woods, S I

2015-07-01

We have developed a cryogenic amplifier for the measurement of small current signals (10 fA-100 nA) from cryogenic optical detectors. Typically operated with gain near 10(7) V/A, the amplifier performs well from DC to greater than 30 kHz and exhibits noise level near the Johnson limit. Care has been taken in the design and materials to control heat flow and temperatures throughout the entire detector-amplifier assembly. A simple one-board version of the amplifier assembly dissipates 8 mW to our detector cryostat cold stage, and a two-board version can dissipate as little as 17 μW to the detector cold stage. With current noise baseline of about 10 fA/(Hz)(1/2), the cryogenic amplifier is generally useful for cooled infrared detectors, and using blocked impurity band detectors operated at 10 K, the amplifier enables noise power levels of 2.5 fW/(Hz)(1/2) for detection of optical wavelengths near 10 μm.

Assessment of commercial optical amplifiers for potential use in space applications

NASA Astrophysics Data System (ADS)

Barbero, Juan; Sotom, Michel; Benazet, Benoit; Esquivias, Ignacio; López Hernández, Francisco José

2017-11-01

This paper describes the activities and results of an ESA-funded project concerned with the assessment of optical amplifier technologies and products for applications in fiber optic subsystems of future satellite payloads. On-board applications are briefly introduced, together with associated system-level requirements. Optical amplifier technologies, research achievements and products are reviewed. They are compared in terms of current performance, perspectives and suitability for the target space applications. Optical fibre amplifiers, not limited to Erbium-doped amplifiers, Erbium-doped waveguide amplifiers and Semiconductor Optical Amplifiers are covered. The review includes analysis and trade-off of all performance parameters including saturation output power, noise figure, polarisation maintaining capability, wall-plug efficiency, and mass and size. A selection of optical amplifier products for further evaluation and testing is presented. Results of extensive testing covering both functional performance and environmental behaviour (mechanical, thermal vacuum, radiations) aspects are reported. Most of the work has been completed, but an extension has been proposed for checking and comparing the behaviour of doped fibers under gamma radiation.

Isolated thermocouple amplifier system for stirred fixed-bed gasifier

DOEpatents

Fasching, George E.

1992-01-01

A sensing system is provided for determining the bed temperature profile of the bed of a stirred, fixed-bed gasifier including a plurality of temperature sensors for sensing the bed temperature at different levels, a transmitter for transmitting data based on the outputs of the sensors to a remote operator's station, and a battery-based power supply. The system includes an isolation amplifier system comprising a plurality of isolation amplifier circuits for amplifying the outputs of the individual sensors. The isolation amplifier circuits each comprise an isolation operational amplifier connected to a sensor; a first "flying capacitor" circuit for, in operation, controlling the application of power from the power supply to the isolation amplifier; an output sample and hold circuit connected to the transmitter; a second "flying capacitor" circuit for, in operation, controlling the transfer of the output of the isolation amplifier to the sample and hold circuit; and a timing and control circuit for activating the first and second capacitor circuits in a predetermined timed sequence.

Design of an Auto-zeroed, Differential, Organic Thin-film Field-effect Transistor Amplifier for Sensor Applications

NASA Technical Reports Server (NTRS)

Binkley, David M.; Verma, Nikhil; Crawford, Robert L.; Brandon, Erik; Jackson, Thomas N.

2004-01-01

Organic strain gauge and other sensors require high-gain, precision dc amplification to process their low-level output signals. Ideally, amplifiers would be fabricated using organic thin-film field-effect transistors (OTFT's) adjacent to the sensors. However, OTFT amplifiers exhibit low gain and high input-referred dc offsets that must be effectively managed. This paper presents a four-stage, cascaded differential OTFT amplifier utilizing switched capacitor auto-zeroing. Each stage provides a nominal voltage gain of four through a differential pair driving low-impedance active loads, which provide common-mode output voltage control. p-type pentacence OTFT's are used for the amplifier devices and auto-zero switches. Simulations indicate the amplifier provides a nominal voltage gain of 280 V/V and effectively amplifies a 1-mV dc signal in the presence of 500-mV amplifier input-referred dc offset voltages. Future work could include the addition of digital gain calibration and offset correction of residual offsets associated with charge injection imbalance in the differential circuits.

Linking manipulative experiments to field data to test the dilution effect.

PubMed

Venesky, Matthew D; Liu, Xuan; Sauer, Erin L; Rohr, Jason R

2014-05-01

The dilution effect, the hypothesis that biodiversity reduces disease risk, has received support in many systems. However, few dilution effect studies have linked mechanistic experiments to field patterns to establish both causality and ecological relevance. We conducted a series of laboratory experiments and tested the dilution effect hypothesis in an amphibian-Batrachochytrium dendrobatidis (Bd) system and tested for consistency between our laboratory experiments and field patterns of amphibian species richness, host identity and Bd prevalence. In our laboratory experiments, we show that tadpoles can filter feed Bd zoospores and that the degree of suspension feeding was positively associated with their dilution potential. The obligate suspension feeder, Gastrophryne carolinensis, generally diluted the risk of chytridiomycosis for tadpoles of Bufo terrestris and Hyla cinerea, whereas tadpoles of B. terrestris (an obligate benthos feeder) generally amplified infections for the other species. In addition, G. carolinensis reduced Bd abundance on H. cinerea more so in the presence than absence of B. terrestris and B. terrestris amplified Bd abundance on H. cinerea more so in the absence than presence of G. carolinensis. Also, when ignoring species identity, species richness was a significant negative predictor of Bd abundance. In our analysis of field data, the presence of Bufo spp. and Gastrophryne spp. were significant positive and negative predictors of Bd prevalence, respectively, even after controlling for climate, vegetation, anthropogenic factors (human footprint), species richness and sampling effort. These patterns of dilution and amplification supported our laboratory findings, demonstrating that the results are likely ecologically relevant. The results from our laboratory and field data support the dilution effect hypothesis and also suggest that dilution and amplification are predictable based on host traits. Our study is among the first to link manipulative experiments, in which a potential dilution mechanism is supported, with analyses of field data on species richness, host identity, spatial autocorrelation and disease prevalence. © 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society.

Picosecond laser system with 30-W average power via cavity dumping and amplifying

NASA Astrophysics Data System (ADS)

Fu, J.; Pang, Q. S.; Chang, L.; Bai, Z. A.; Ai, Q. K.; Chen, L. Y.; Chen, M.; Li, G.; Ma, Y. F.; Fan, Z. W.; Niu, G.; Yu, J.; Liu, Y.; Zhang, X.; Kang, W. Y.; He, K.

2011-06-01

We present a picosecond laser system with high energy by technologies of cavity dumping and amplifying. Firstly, pulses with 10 ps and ˜520 nJ were obtained by cavity-dumped mode-locked laser at 10 kHz repetition rate. Secondly those pulses were seeded into a side-pumped regenerative amplifier (RA). Then pulses output from the regenerative amplifier were amplified by two four-pass post amplifiers. From the laser system pulses with an average power of 30 W corresponding to 3 mJ pulse energy were achieved with the pulse-width of 25.4 ps at repetition rate of 10 kHz.

Segmented amplifier configurations for laser amplifier

DOEpatents

Hagen, Wilhelm F.

1979-01-01

An amplifier system for high power lasers, the system comprising a compact array of segments which (1) preserves high, large signal gain with improved pumping efficiency and (2) allows the total amplifier length to be shortened by as much as one order of magnitude. The system uses a three dimensional array of segments, with the plane of each segment being oriented at substantially the amplifier medium Brewster angle relative to the incident laser beam and with one or more linear arrays of flashlamps positioned between adjacent rows of amplifier segments, with the plane of the linear array of flashlamps being substantially parallel to the beam propagation direction.

Note: A high dynamic range, linear response transimpedance amplifier.

PubMed

Eckel, S; Sushkov, A O; Lamoreaux, S K

2012-02-01

We have built a high dynamic range (nine decade) transimpedance amplifier with a linear response. The amplifier uses junction-gate field effect transistors (JFETs) to switch between three different resistors in the feedback of a low input bias current operational amplifier. This allows for the creation of multiple outputs, each with a linear response and a different transimpedance gain. The overall bandwidth of the transimpedance amplifier is set by the bandwidth of the most sensitive range. For our application, we demonstrate a three-stage amplifier with transimpedance gains of approximately 10(9)Ω, 3 × 10(7)Ω, and 10(4)Ω with a bandwidth of 100 Hz.

High speed preamplifier circuit, detection electronics, and radiation detection systems therefrom

DOEpatents

Riedel, Richard A [Knoxville, TN; Wintenberg, Alan L [Knoxville, TN; Clonts, Lloyd G [Knoxville, TN; Cooper, Ronald G [Oak Ridge, TN

2010-09-21

A preamplifier circuit for processing a signal provided by a radiation detector includes a transimpedance amplifier coupled to receive a current signal from a detector and generate a voltage signal at its output. A second amplification stage has an input coupled to an output of the transimpedance amplifier for providing an amplified voltage signal. Detector electronics include a preamplifier circuit having a first and second transimpedance amplifier coupled to receive a current signal from a first and second location on a detector, respectively, and generate a first and second voltage signal at respective outputs. A second amplification stage has an input coupled to an output of the transimpedance amplifiers for amplifying the first and said second voltage signals to provide first and second amplified voltage signals. A differential output stage is coupled to the second amplification stage for receiving the first and second amplified voltage signals and providing a pair of outputs from each of the first and second amplified voltage signals. Read out circuitry has an input coupled to receive both of the pair of outputs, the read out circuitry having structure for processing each of the pair of outputs, and providing a single digital output having a time-stamp therefrom.

The Realization and Analysis of Capacitance Self Tracing (CST) Method for Wide Band Response Measurement of Carrier Type Dynamic Strain Amplifier

NASA Astrophysics Data System (ADS)

Kubodera, Shinji; Tanzawa, Tsutomu; Morisawa, Masayuki; Kiyohiro, Noriaki

Carrier type dynamic strain amplifiers are frequently used for stress measurement with strain gages. That is because the carrier type dynamic strain amplifier can conduct high precision measurement since it is highly resistant against hum noise from the power supply frequency in principle and is free from the thermoelectomotive force even if a metal contact is used in wiring to a Wheatstone bridge for measuring. A problem of the carrier type dynamic strain amplifier is generation of Capacitive component (hereinafter referred to as the C component) in an input cable connecting from the amplifier to the input sensor (Wheatstone bridge for measuring). The C component varies with cable length, cable materials, or ambient temperature change. The aforementioned changing adversely affects the stability of the amplifier. In this paper, we realize and analyze the method that increases the stability of amplifier by detecting, eliminating and self tracking the above C component constantly. Used carrier frequency at 12kHz and 28kHz. We made amplifiers with noise resistant and wide band frequency of measurement range and verified the theory of the Capacitance Self Tracing with the above amplifiers.

Radiation detection system

DOEpatents

Riedel, Richard A [Knoxville, TN; Wintenberg, Alan L [Knoxville, TN; Clonts, Lloyd G [Knoxville, TN; Cooper, Ronald G [Oak Ridge, TN

2012-02-14

A preamplifier circuit for processing a signal provided by a radiation detector includes a transimpedance amplifier coupled to receive a current signal from a detector and generate a voltage signal at its output. A second amplification stage has an input coupled to an output of the transimpedance amplifier for providing an amplified voltage signal. Detector electronics include a preamplifier circuit having a first and second transimpedance amplifier coupled to receive a current signal from a first and second location on a detector, respectively, and generate a first and second voltage signal at respective outputs. A second amplification stage has an input coupled to an output of the transimpedance amplifiers for amplifying the first and said second voltage signals to provide first and second amplified voltage signals. A differential output stage is coupled to the second amplification stage for receiving the first and second amplified voltage signals and providing a pair of outputs from each of the first and second amplified voltage signals. Read out circuitry has an input coupled to receive both of the pair of outputs, the read out circuitry having structure for processing each of the pair of outputs, and providing a single digital output having a time-stamp therefrom.

Design of ultra-low power biopotential amplifiers for biosignal acquisition applications.

PubMed

Zhang, Fan; Holleman, Jeremy; Otis, Brian P

2012-08-01

Rapid development in miniature implantable electronics are expediting advances in neuroscience by allowing observation and control of neural activities. The first stage of an implantable biosignal recording system, a low-noise biopotential amplifier (BPA), is critical to the overall power and noise performance of the system. In order to integrate a large number of front-end amplifiers in multichannel implantable systems, the power consumption of each amplifier must be minimized. This paper introduces a closed-loop complementary-input amplifier, which has a bandwidth of 0.05 Hz to 10.5 kHz, an input-referred noise of 2.2 μ Vrms, and a power dissipation of 12 μW. As a point of comparison, a standard telescopic-cascode closed-loop amplifier with a 0.4 Hz to 8.5 kHz bandwidth, input-referred noise of 3.2 μ Vrms, and power dissipation of 12.5 μW is presented. Also for comparison, we show results from an open-loop complementary-input amplifier that exhibits an input-referred noise of 3.6 μ Vrms while consuming 800 nW of power. The two closed-loop amplifiers are fabricated in a 0.13 μ m CMOS process. The open-loop amplifier is fabricated in a 0.5 μm SOI-BiCMOS process. All three amplifiers operate with a 1 V supply.

Precision absolute-value amplifier for a precision voltmeter

DOEpatents

Hearn, W.E.; Rondeau, D.J.

1982-10-19

Bipolar inputs are afforded by the plus inputs of first and second differential input amplifiers. A first gain determining resistor is connected between the minus inputs of the differential amplifiers. First and second diodes are connected between the respective minus inputs and the respective outputs of the differential amplifiers. First and second FETs have their gates connected to the outputs of the amplifiers, while their respective source and drain circuits are connected between the respective minus inputs and an output lead extending to a load resistor. The output current through the load resistor is proportional to the absolute value of the input voltage difference between the bipolar input terminals. A third differential amplifier has its plus input terminal connected to the load resistor. A second gain determining resistor is connected between the minus input of the third differential amplifier and a voltage source. A third FET has its gate connected to the output of the third amplifier. The source and drain circuit of the third transistor is connected between the minus input of the third amplifier and a voltage-frequency converter, constituting an output device. A polarity detector is also provided, comprising a pair of transistors having their inputs connected to the outputs of the first and second differential amplifiers. The outputs of the polarity detector are connected to gates which switch the output of the voltage-frequency converter between up and down counting outputs.

Precision absolute value amplifier for a precision voltmeter

DOEpatents

Hearn, William E.; Rondeau, Donald J.

1985-01-01

Bipolar inputs are afforded by the plus inputs of first and second differential input amplifiers. A first gain determining resister is connected between the minus inputs of the differential amplifiers. First and second diodes are connected between the respective minus inputs and the respective outputs of the differential amplifiers. First and second FETs have their gates connected to the outputs of the amplifiers, while their respective source and drain circuits are connected between the respective minus inputs and an output lead extending to a load resister. The output current through the load resister is proportional to the absolute value of the input voltage difference between the bipolar input terminals. A third differential amplifier has its plus input terminal connected to the load resister. A second gain determining resister is connected between the minus input of the third differential amplifier and a voltage source. A third FET has its gate connected to the output of the third amplifier. The source and drain circuit of the third transistor is connected between the minus input of the third amplifier and a voltage-frequency converter, constituting an output device. A polarity detector is also provided, comprising a pair of transistors having their inputs connected to the outputs of the first and second differential amplifiers. The outputs of the polarity detector are connected to gates which switch the output of the voltage-frequency converter between up and down counting outputs.

Learning a locomotor task: with or without errors?

PubMed

Marchal-Crespo, Laura; Schneider, Jasmin; Jaeger, Lukas; Riener, Robert

2014-03-04

Robotic haptic guidance is the most commonly used robotic training strategy to reduce performance errors while training. However, research on motor learning has emphasized that errors are a fundamental neural signal that drive motor adaptation. Thus, researchers have proposed robotic therapy algorithms that amplify movement errors rather than decrease them. However, to date, no study has analyzed with precision which training strategy is the most appropriate to learn an especially simple task. In this study, the impact of robotic training strategies that amplify or reduce errors on muscle activation and motor learning of a simple locomotor task was investigated in twenty two healthy subjects. The experiment was conducted with the MAgnetic Resonance COmpatible Stepper (MARCOS) a special robotic device developed for investigations in the MR scanner. The robot moved the dominant leg passively and the subject was requested to actively synchronize the non-dominant leg to achieve an alternating stepping-like movement. Learning with four different training strategies that reduce or amplify errors was evaluated: (i) Haptic guidance: errors were eliminated by passively moving the limbs, (ii) No guidance: no robot disturbances were presented, (iii) Error amplification: existing errors were amplified with repulsive forces, (iv) Noise disturbance: errors were evoked intentionally with a randomly-varying force disturbance on top of the no guidance strategy. Additionally, the activation of four lower limb muscles was measured by the means of surface electromyography (EMG). Strategies that reduce or do not amplify errors limit muscle activation during training and result in poor learning gains. Adding random disturbing forces during training seems to increase attention, and therefore improve motor learning. Error amplification seems to be the most suitable strategy for initially less skilled subjects, perhaps because subjects could better detect their errors and correct them. Error strategies have a great potential to evoke higher muscle activation and provoke better motor learning of simple tasks. Neuroimaging evaluation of brain regions involved in learning can provide valuable information on observed behavioral outcomes related to learning processes. The impacts of these strategies on neurological patients need further investigations.

Atomic layer deposition of highly-doped Er:Al2O3 and Tm:Al2O3 for silicon-based waveguide amplifiers (Conference Presentation)

NASA Astrophysics Data System (ADS)

Roenn, John; Karvonen, Lasse; Pyymäki-Perros, Alexander; Peyghambarian, Nasser; Lipsanen, Harri; Säynätjoki, Antti; Sun, Zhipei

2016-05-01

Recently, rare-earth doped waveguide amplifiers (REDWAs) have drawn significant attention as a promising solution to on-chip amplification of light in silicon photonics and integrated optics by virtue of their high excited state lifetime (up to 10 ms) and broad emission spectrum (up to 200 nm) at infrared wavelengths. In the family of rare-earths, at least erbium, holmium, thulium, neodymium and ytterbium have been demonstrated to be good candidates for amplifier operation at moderate concentrations (< 0.1 %). However, efficient amplifier operation in REDWAs is a very challenging task because high concentration of ions (<0.1%) is required in order to produce reasonable amplification over short device length. Inevitably, high concentration of ions leads to energy-transfer between neighboring ions, which results as decreased gain and increased noise in the amplifier system. It has been shown that these energy-transfer mechanisms in highly-doped gain media are inversely proportional to the sixth power of the distance between the ions. Therefore, novel fabrication techniques with the ability to control the distribution of the rare-earth ions within the gain medium are urgently needed in order to fabricate REDWAs with high efficiency and low noise. Here, we show that atomic layer deposition (ALD) is an excellent technique to fabricate highly-doped (<1%) RE:Al2O3 gain materials by using its nanoscale engineering ability to delicately control the incorporation of RE ions during the deposition. In our experiment, we fabricated Er:Al2O3 and Tm:Al2O3 thin films with ALD by varying the concentration of RE ions from 1% to 7%. By measuring the photoluminescence response of the fabricated samples, we demonstrate that it is possible to incorporate up to 5% of either Er- or Tm-ions in Al2O3 host before severe quenching occurs. We believe that this technique can be extended to other RE ions as well. Therefore, our results show the exceptionality of ALD as a deposition technique for REDWA technology.

Implementation of a digital evaluation platform to analyze bifurcation based nonlinear amplifiers

NASA Astrophysics Data System (ADS)

Feldkord, Sven; Reit, Marco; Mathis, Wolfgang

2016-09-01

Recently, nonlinear amplifiers based on the supercritical Andronov-Hopf bifurcation have become a focus of attention, especially in the modeling of the mammalian hearing organ. In general, to gain deeper insights in the input-output behavior, the analysis of bifurcation based amplifiers requires a flexible framework to exchange equations and adjust certain parameters. A DSP implementation is presented which is capable to analyze various amplifier systems. Amplifiers based on the Andronov-Hopf and Neimark-Sacker bifurcations are implemented and compared exemplarily. It is shown that the Neimark-Sacker system remarkably outperforms the Andronov-Hopf amplifier regarding the CPU usage. Nevertheless, both show a similar input-output behavior over a wide parameter range. Combined with an USB-based control interface connected to a PC, the digital framework provides a powerful instrument to analyze bifurcation based amplifiers.

Broadband linear high-voltage amplifier for radio frequency ion traps.

PubMed

Kuhlicke, Alexander; Palis, Klaus; Benson, Oliver

2014-11-01

We developed a linear high-voltage amplifier for small capacitive loads consisting of a high-voltage power supply and a transistor amplifier. With this cost-effective circuit including only standard parts sinusoidal signals with a few volts can be amplified to 1.7 kVpp over a usable frequency range at large-signal response spanning four orders of magnitude from 20 Hz to 100 kHz under a load of 10 pF. For smaller output voltages the maximum frequency shifts up to megahertz. We test different capacitive loads to probe the influence on the performance. The presented amplifier is sustained short-circuit proof on the output side, which is a significant advantage over other amplifier concepts. The amplifier can be used to drive radio frequency ion traps for single charged nano- and microparticles, which will be presented in brief.

Multiple Differential-Amplifier MMICs Embedded in Waveguides

NASA Technical Reports Server (NTRS)

Kangaslahti, Pekka; Schlecht, Erich

2010-01-01

Compact amplifier assemblies of a type now being developed for operation at frequencies of hundreds of gigahertz comprise multiple amplifier units in parallel arrangements to increase power and/or cascade arrangements to increase gains. Each amplifier unit is a monolithic microwave integrated circuit (MMIC) implementation of a pair of amplifiers in differential (in contradistinction to single-ended) configuration. Heretofore, in cascading amplifiers to increase gain, it has been common practice to interconnect the amplifiers by use of wires and/or thin films on substrates. This practice has not yielded satisfactory results at frequencies greater than 200 Hz, in each case, for either or both of two reasons: Wire bonds introduce large discontinuities. Because the interconnections are typically tens of wavelengths long, any impedance mismatches give rise to ripples in the gain-vs.-frequency response, which degrade the performance of the cascade.

The 20 GHz spacecraft FET solid state transmitter

NASA Technical Reports Server (NTRS)

1983-01-01

The engineering development of a solid state transmitter amplifier operating in the 20 GHz frequency band using GaAs field effect transistors (FETs) was detailed. The major efforts include GaAs FET device development, single-ended amplifier stage, balanced amplifier stage, cascaded stage and radial combiner designs, and amplifier integration and test. A multistage GaAs FET amplifier capable of 8.2 W CW output over the 17.9 to 19.1 GHz frequency band was developed. The GaAs FET devices developed represent state of the art FET power device technology. Further device improvements are necessary to increase the bandwidth to 2.5 GHz, improve dc-to-RF efficiency, and increase power capability at the device level. Higher power devices will simplify the amplifier combining scheme, reducing the size and weight of the overall amplifier.

Transient signal isotope analysis: validation of the method for isotope signal synchronization with the determination of amplifier first-order time constants.

PubMed

Gourgiotis, Alkiviadis; Manhès, Gérard; Louvat, Pascale; Moureau, Julien; Gaillardet, Jérôme

2015-09-30

During transient signal acquisition by Multi-Collection Inductively Coupled Plasma Mass Spectrometry (MC-ICPMS), an isotope ratio increase or decrease (isotopic drift hereafter) is often observed which is related to the different time responses of the amplifiers involved in multi-collection. This isotopic drift affects the quality of the isotopic data and, in a recent study, a method of internal amplifier signal synchronization for isotope drift correction was proposed. In this work the determination of the amplifier time constants was investigated in order to validate the method of internal amplifier signal synchronization for isotope ratio drift correction. Two different MC-ICPMS instruments, the Neptune and the Neptune Plus, were used, and both the lead transient signals and the signal decay curves of the amplifiers were investigated. Our results show that the first part of the amplifier signal decay curve is characterized by a pure exponential decay. This part of the signal decay was used for the effective calculation of the amplifier first-order time constants. The small differences between these time constants were compared with time lag values obtained from the method of isotope signal synchronization and were found to be in good agreement. This work proposes a way of determining amplifier first-order time constants. We show that isotopic drift is directly related to the amplifier first-order time constants and the method of internal amplifier signal synchronization for isotope ratio drift correction is validated. Copyright © 2015 John Wiley & Sons, Ltd.

Series transistors isolate amplifier from flyback voltage

NASA Technical Reports Server (NTRS)

Banks, W.

1967-01-01

Circuit enables high sawtooth currents to be passed through a deflection coil and isolate the coil driving amplifier from the flyback voltage. It incorporates a switch consisting of transistors in series with the driving amplifier and deflection coil. The switch disconnects the deflection coil from the amplifier during the retrace time.

Active rc filter permits easy trade-off of amplifier gain and sensitivity to gain

NASA Technical Reports Server (NTRS)

Kerwin, W. J.; Shaffer, C. V.

1968-01-01

Passive RC network was designed with zeros of transmission in the right half of the complex frequency plane in the feedback loop of a simple negative-gain amplifier. The proper positioning provides any desired trade-off between amplifier gain and sensitivity to amplifier gain.

An Introduction to Phase-Sensitive Amplifiers: An Inexpensive Student Instrument

ERIC Educational Resources Information Center

Temple, Paul A.

1975-01-01

Discusses the principle of operation of phase-sensitive amplifiers. Gives three examples, suitable for undergraduate laboratory use, of the use of phase-sensitive, or "lock-in" amplifiers. Concludes with a description of an inexpensive lock-in amplifier which has an overall voltage gain of 1000. (Author/MLH)

Pyroelectric Energy Harvesting: Model and Experiments

DTIC Science & Technology

2016-05-01

consisting of a current source for the pyroelectric current, a dielectric capacitor for the adiabatic charging and discharging, and optionally a resistor to...polarization) in a piezoelectric material. To extract work from the pyroelectric effect, the material acts as the dielectric in a capacitor that is...amplifier was chosen for the setup. The pyroelectric element is commonly modeled as a dielectric capacitor and a current source in parallel, as seen in

The Role of Excitons on Light Amplification in Lead Halide Perovskites.

PubMed

Lü, Quan; Wei, Haohan; Sun, Wenzhao; Wang, Kaiyang; Gu, Zhiyuan; Li, Jiankai; Liu, Shuai; Xiao, Shumin; Song, Qinghai

2016-12-01

The role of excitons on the amplifications of lead halide perovskites has been explored. Unlike the photoluminescence, the intensity of amplified spontaneous emission is partially suppressed at low temperature. The detailed analysis and experiments show that the inhibition is attributed to the existence of exciton and a quantitative model has been built to explain the experimental observations. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Microresonator Frequency Comb Optical Clock

DTIC Science & Technology

2014-07-22

lithic construction with small size and power consumption. Microcomb development has included frequency control of their spectra [8–11...frequency f eo and amplified to a maximum of 140 mW. The first-order sideband powers are approximately 3 dB lower than the pump, and the piece of highly...resonator offers sufficient peak power for our experiments and is stable and repeatable even for different settings of pump frequency and power

Study on signal intensity of low field nuclear magnetic resonance via an indirect coupling measurement

NASA Astrophysics Data System (ADS)

Jiang, Feng-Ying; Wang, Ning; Jin, Yi-Rong; Deng, Hui; Tian, Ye; Lang, Pei-Lin; Li, Jie; Chen, Ying-Fei; Zheng, Dong-Ning

2013-04-01

We carry out an ultra-low-field nuclear magnetic resonance (NMR) experiment based on high-Tc superconducting quantum interference devices (SQUIDs). The measurement field is in a micro-tesla range (~10 μT-100 μT) and the experiment is conducted in a home-made magnetically-shielded-room (MSR). The measurements are performed by the indirect coupling method in which the signal of nuclei precession is indirectly coupled to the SQUID through a tuned copper coil transformer. In such an arrangement, the interferences of applied measurement and polarization field to the SQUID sensor are avoided and the performance of the SQUID is not destroyed. In order to compare the detection sensitivity obtained by using the SQUID with that achieved using a conventional low-noise-amplifier, we perform the measurements using a commercial room temperature amplifier. The results show that in a wide frequency range (~1 kHz-10 kHz) the measurements with the SQUID sensor exhibit a higher signal-to-noise ratio. Further, we discuss the dependence of NMR peak magnitude on measurement frequency. We attribute the reduction of the peak magnitude at high frequency to the increased field inhomogeneity as the measurement field increases. This is verified by compensating the field gradient using three sets of gradient coils.

Noise from implantable Cooper cable.

PubMed

Carrington, V; Zhou, L; Donaldson, N

2005-09-01

Cooper cable is made for implanted devices, usually for connection to stimulating electrodes. An experiment has been performed to see whether these cables would be satisfactory for recording electroneurogram (ENG) signals from cuffs. Four cables were subjected to continuous flexion at 2 Hz while submerged in saline. The cables were connected to a low-noise amplifier, and the noise was measured using a spectrum analyser. These cables had not fractured after 184 million flexions, and the noise in the neural band (500-5000 Hz) had not increased owing to age. Noise in the ENG band increased by less than 3 dB owing to the motion. A fifth, worn cable did fail during the experiment, the conductors becoming exposed to the saline, but this was only apparent by extra noise when the cable was in motion. After 184 million flexions, the four cables were given a more severe test: instead of being connected to the amplifier reference node, two of the four cores of each cable were connected to 18V batteries. Two of the cables were then noisier, but only when in motion, presumably because of leakage between cores. Cooper cables are excellent for transmitting neural signals alone; transmission in one cable of neural signals and power supplies should be avoided if possible.

Monolithic circuits for barium fluoride detectors used in nuclear physics experiments. CRADA final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varner, R.L.; Blankenship, J.L.; Beene, J.R.

1998-02-01

Custom monolithic electronic circuits have been developed recently for large detector applications in high energy physics where subsystems require tens of thousands of channels of signal processing and data acquisition. In the design and construction of these enormous detectors, it has been found that monolithic circuits offer significant advantages over discrete implementations through increased performance, flexible packaging, lower power and reduced cost per channel. Much of the integrated circuit design for the high energy physics community is directly applicable to intermediate energy heavy-ion and electron physics. This STTR project conducted in collaboration with researchers at the Holifield Radioactive Ion Beammore » Facility (HRIBF) at Oak Ridge National Laboratory, sought to develop a new integrated circuit chip set for barium fluoride (BaF{sub 2}) detector arrays based upon existing CMOS monolithic circuit designs created for the high energy physics experiments. The work under the STTR Phase 1 demonstrated through the design, simulation, and testing of several prototype chips the feasibility of using custom CMOS integrated circuits for processing signals from BaF{sub 2} detectors. Function blocks including charge-sensitive amplifiers, comparators, one shots, time-to-amplitude converters, analog memory circuits and buffer amplifiers were implemented during Phase 1 effort. Experimental results from bench testing and laboratory testing with sources were documented.« less

Narrow linewidth diode laser modules for quantum optical sensor applications in the field and in space

NASA Astrophysics Data System (ADS)

Wicht, A.; Bawamia, A.; Krüger, M.; Kürbis, Ch.; Schiemangk, M.; Smol, R.; Peters, A.; Tränkle, G.

2017-02-01

We present the status of our efforts to develop very compact and robust diode laser modules specifically suited for quantum optics experiments in the field and in space. The paper describes why hybrid micro-integration and GaAs-diode laser technology is best suited to meet the needs of such applications. The electro-optical performance achieved with hybrid micro-integrated, medium linewidth, high power distributed-feedback master-oscillator-power-amplifier modules and with medium power, narrow linewidth extended cavity diode lasers emitting at 767 nm and 780 nm are briefly described and the status of space relevant stress tests and space heritage is summarized. We also describe the performance of an ECDL operating at 1070 nm. Further, a novel and versatile technology platform is introduced that allows for integration of any type of laser system or electro-optical module that can be constructed from two GaAs chips. This facilitates, for the first time, hybrid micro-integration, e.g. of extended cavity diode laser master-oscillator-poweramplifier modules, of dual-stage optical amplifiers, or of lasers with integrated, chip-based phase modulator. As an example we describe the implementation of an ECDL-MOPA designed for experiments on ultra-cold rubidium and potassium atoms on board a sounding rocket and give basic performance parameters.

Gravity amplifies and microgravity decreases circumnutations in Arabidopsis thaliana stems: results from a space experiment.

PubMed

Johnsson, A; Solheim, B G B; Iversen, T-H

2009-01-01

In a microgravity experiment onboard the International Space Station, circumnutations of Arabidopsis thaliana were studied. Plants were cultivated on rotors under a light:dark (LD) cycle of 16 : 8 h, and it was possible to apply controlled centrifugation pulses. Time-lapse images of inflorescence stems (primary, primary axillary and lateral inflorescences) documented the effect of microgravity on the circumnutations. Self-sustained circumnutations of side stems were present in microgravity but amplitudes were mostly very small. In darkness, centrifugation at 0.8 g increased the amplitude by a factor of five to ten. The period at 0.8 g was c. 85 min, in microgravity roughly of the same magnitude. In white light the period decreased to c. 60 min at 0.8 g (microgravity value not measurable). Three-dimensional data showed that under 0.8 g side stems rotated in both clockwise and counter-clockwise directions. Circumnutation data for the main stem in light showed a doubling of the amplitude and a longer period at 0.8 g than in microgravity (c. 80 vs 60 min). For the first time, the importance of gravity in amplifying minute oscillatory movements in microgravity into high-amplitude circumnutations was unequivocally demonstrated. The importance of these findings for the modelling of gravity effects on self-sustained oscillatory movements is discussed.

Common arbuscular mycorrhizal networks amplify competition for phosphorus between seedlings and established plants.

PubMed

Merrild, Marie P; Ambus, Per; Rosendahl, Søren; Jakobsen, Iver

2013-10-01

Common mycorrhizal networks (CMNs) influence competition between plants, but reports regarding their precise effect are conflicting. We studied CMN effects on phosphorus (P) uptake and growth of seedlings as influenced by various disruptions of network components. Tomato (Solanum lycopersicon) seedlings grew into established networks of Rhizophagus irregularis and cucumber (Cucumis sativus) in two experiments. One experiment studied seedling uptake of (32)P in the network in response to cutting of cucumber shoots; the other analysed seedling uptake of P and nitrogen (N) in the presence of intact or severed arbuscular mycorrhizal fungus networks and at two soil P concentrations. Pre-established and intact networks suppressed growth of tomato seedlings. Cutting of cucumber shoots mitigated P deficiency symptoms of seedlings, which obtained access to P in the extraradical mycelium and thereby showed improved growth. Solitary seedlings growing in a network patch that had been severed from the CMN also grew much better than seedlings of the corresponding CMN. Interspecific and size-asymmetric competition between plants may be amplified rather than relaxed by CMNs that transfer P to large plants providing most carbon and render small plants P deficient. It is likely that grazing or senescence of the large plants will alleviate the network-induced suppression of seedling growth. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.

Face-to-face: Perceived personal relevance amplifies face processing.

PubMed

Bublatzky, Florian; Pittig, Andre; Schupp, Harald T; Alpers, Georg W

2017-05-01

The human face conveys emotional and social information, but it is not well understood how these two aspects influence face perception. In order to model a group situation, two faces displaying happy, neutral or angry expressions were presented. Importantly, faces were either facing the observer, or they were presented in profile view directed towards, or looking away from each other. In Experiment 1 (n = 64), face pairs were rated regarding perceived relevance, wish-to-interact, and displayed interactivity, as well as valence and arousal. All variables revealed main effects of facial expression (emotional > neutral), face orientation (facing observer > towards > away) and interactions showed that evaluation of emotional faces strongly varies with their orientation. Experiment 2 (n = 33) examined the temporal dynamics of perceptual-attentional processing of these face constellations with event-related potentials. Processing of emotional and neutral faces differed significantly in N170 amplitudes, early posterior negativity (EPN), and sustained positive potentials. Importantly, selective emotional face processing varied as a function of face orientation, indicating early emotion-specific (N170, EPN) and late threat-specific effects (LPP, sustained positivity). Taken together, perceived personal relevance to the observer-conveyed by facial expression and face direction-amplifies emotional face processing within triadic group situations. © The Author (2017). Published by Oxford University Press.

Waveguide Power-Amplifier Module for 80 to 150 GHz

NASA Technical Reports Server (NTRS)

Samoska, Lorene; Weinreb, Sander; Peralta, Alejandro

2006-01-01

A waveguide power-amplifier module capable of operating over the frequency range from 80 to 150 GHz has been constructed. The module comprises a previously reported power amplifier packaged in a waveguide housing that is compatible with WR-8 waveguides. (WR- 8 is a standard waveguide size for the nominal frequency range from 90 to 140 GHz.) The waveguide power-amplifier module is robust and can be bolted to test equipment and to other electronic circuits with which the amplifier must be connected for normal operation.

Optical Amplifier for Space Applications

NASA Technical Reports Server (NTRS)

Fork, Richard L.; Cole, Spencer T.; Gamble, Lisa J.; Diffey, William M.; Keys, Andrew S.

1999-01-01

We describe an optical amplifier designed to amplify a spatially sampled component of an optical wavefront to kilowatt average power. The goal is means for implementing a strategy of spatially segmenting a large aperture wavefront, amplifying the individual segments, maintaining the phase coherence of the segments by active means, and imaging the resultant amplified coherent field. Applications of interest are the transmission of space solar power over multi-megameter distances, as to distant spacecraft, or to remote sites with no preexisting power grid.

A Study of Photoreceivers for Free-Space, Analog, Intensity-Modulated, Direct-Detection Optical Links Operating at Microwave Frequencies

DTIC Science & Technology

2010-09-10

photodiode with internal resistor followed by a high-gain RF amplifier , and c) a p-i-n photodiode followed by a transimpedance amplifier (TIA). We...gain, RF electrical amplifier ; and 3) a p-i-n photodiode followed by a transimpedance amplifier . Finally, we perform calculations to predict the...common photoreceiver is a p-i-n or avalanche photodiode with a built-in transimpedance amplifier (TIA) and often incorporating automatic gain control

Preliminary studies of radiation coupling between remote soft X-ray laser amplifiers

NASA Astrophysics Data System (ADS)

Cairns, G.; Lewis, C. L. S.; Macphee, A. G.; Neely, D.; Holden, M.; Krishnan, J.; Tallents, G. J.; Key, M. H.; Norreys, P. N.; Smith, C. G.; Zhang, J.; Holden, P. B.; Pert, G. J.; Plowes, J.; Ramsden, S. A.

1994-01-01

Coupling of a soft X-ray laser beam with a relaying concave mirror in a sequentially pumped amplifier geometry using the Ne-like Ge system has been studied experimentally. Preliminary observations indicate an increase in the spatial coherence of the amplified relayed beam. In addition, near-field imaging of one of the amplifier plasmas shows a double-lobed intensity pattern of the emergent beam indicating refractive guiding of the amplified beam with components both normal and tangential to the target surface.

Modeling a Common-Source Amplifier Using a Ferroelectric Transistor

NASA Technical Reports Server (NTRS)

Sayyah, Rana; Hunt, Mitchell; MacLeond, Todd C.; Ho, Fat D.

2010-01-01

This paper presents a mathematical model characterizing the behavior of a common-source amplifier using a FeFET. The model is based on empirical data and incorporates several variables that affect the output, including frequency, load resistance, and gate-to-source voltage. Since the common-source amplifier is the most widely used amplifier in MOS technology, understanding and modeling the behavior of the FeFET-based common-source amplifier will help in the integration of FeFETs into many circuits.

Yb:YAG master oscillator power amplifier for remote wind sensing.

PubMed

Sridharan, A K; Saraf, S; Byer, R L

2007-10-20

We have demonstrated key advances towards a solid-state laser amplifier at 1.03 microm for global remote wind sensing. We designed end-pumped zig-zag slab amplifiers to achieve high gain. We overcame parasitic oscillation limitations using claddings on the slab's total internal reflection (TIR) and edge surfaces to confine the pump and signal light by TIR and allow leakage of amplified spontaneous emission rays that do not meet the TIR condition. This enables e3, e5, and e8 single-, double-, and quadruple-pass small-signal amplifier gain, respectively. The stored energy density is 15.6 J/cm3, a record for a laser-diode end-pumped Yb:YAG zig-zag slab amplifier.

Investigation into the common mode rejection ratio of the physiological signal conditioner circuit

NASA Technical Reports Server (NTRS)

Obrien, Edward M.

1992-01-01

The common mode rejection ratio (CMRR) of the single operational amplifier (op amp) differential amplifier and of the three operational amplifier differential amplifier was investigated. The three op amp differential amplifier circuit is used in the signal conditioner circuit which amplifies signals such as the electromyograph or electrocardiogram. The investigation confirmed via SPICE modeling what has been observed by others in the recent literature that the CMRR for the circuit can be maximized without precision resistor values or precisely matched op amps. This can be done if one resistor in the final stage can be adjusted either by a potentiometer or by laser trimming in the case of hybrid circuit fabrication.

MMIC HEMT Power Amplifier for 140 to 170 GHz

NASA Technical Reports Server (NTRS)

Samoska, Lorene; Radisic, Vesna; Ngo, Catherine; Janke, Paul; Hu, Ming; Micovic, Miro

2003-01-01

A three-stage monolithic microwave integrated circuit (MMIC) power amplifier that features high-electron-mobility transistors (HEMTs) as gain elements is reviewed. This amplifier is designed to operate in the frequency range of 140 to 170 GHz, which contains spectral lines of several atmospheric molecular species plus subharmonics of other such spectral lines. Hence, this amplifier could serve as a prototype of amplifiers to be incorporated into heterodyne radiometers used in atmospheric science. The original intended purpose served by this amplifier is to boost the signal generated by a previously developed 164-GHz MMIC HEMT doubler and drive a 164-to-328-GHz doubler to provide a few milliwatts of power at 328 GHz.

Cryogenic ultra-low-noise SiGe transistor amplifier.

PubMed

Ivanov, B I; Trgala, M; Grajcar, M; Il'ichev, E; Meyer, H-G

2011-10-01

An ultra-low-noise one-stage SiGe heterojunction bipolar transistor amplifier was designed for cryogenic temperatures and a frequency range of 10 kHz-100 MHz. A noise temperature T(N) ≈ 1.4 K was measured at an ambient temperature of 4.2 K at frequencies between 100 kHz and 100 MHz for a source resistance of ~50 Ω. The voltage gain of the amplifier was 25 dB at a power consumption of 720 μW. The input voltage noise spectral density of the amplifier is about 35 pV/√Hz. The low noise resistance and power consumption makes the amplifier suitable for readout of resistively shunted DC SQUID magnetometers and amplifiers.

Fiber optic signal amplifier using thermoelectric power generation

DOEpatents

Hart, M.M.

1993-01-01

A remote fiber optic signal amplifier for use as a repeater/amplifier, such as in transoceanic communication, powered by a Pu{sub 238} or Sr{sub 90} thermoelectric generator. The amplifier comprises a unit with connections on the receiving and sending sides of the communications system, and an erbium-doped fiber amplifier connecting each sending fiber to each receiving fiber. The thermoelectric generator, preferably a Pu{sub 238} or Sr{sub 90} thermoelectric generator delivers power to the amplifiers through a regulator. The heat exchange surfaces of the thermoelectric generator are made of material resistant to corrosion and biological growth and are directly exposed to the outside, such as the ocean water in transoceanic communications.

Fiber optic signal amplifier using thermoelectric power generation

DOEpatents

Hart, M.M.

1995-04-18

A remote fiber optic signal amplifier for use as a repeater/amplifier, such as in transoceanic communications, powered by a Pu{sub 238} or Sr{sub 90} thermoelectric generator. The amplifier comprises a unit with connections on the receiving and sending sides of the communications system, and an erbium-doped fiber amplifier connecting each sending fiber to each receiving fiber. The thermoelectric generator, preferably a Pu{sub 238} or Sr{sub 90} thermoelectric generator delivers power to the amplifiers through a regulator. The heat exchange surfaces of the thermoelectric generator are made of materials resistant to corrosion and biological growth and are directly exposed to the outside, such as the ocean water in transoceanic communications. 2 figs.

Fiber optic signal amplifier using thermoelectric power generation

DOEpatents

Hart, Mark M.

1995-01-01

A remote fiber optic signal amplifier for use as a repeater/amplifier, such as in transoceanic communications, powered by a Pu.sub.238 or Sr.sub.90 thermoelectric generator. The amplifier comprises a unit with connections on the receiving and sending sides of the communications system, and an erbium-doped fiber amplifier connecting each sending fiber to each receiving fiber. The thermoelectric generator, preferably a Pu.sub.238 or Sr.sub.90 thermoelectric generator delivers power to the amplifiers through a regulator. The heat exchange surfaces of the thermoelectric generator are made of materials resistant to corrosion and biological growth and are directly exposed to the outside, such as the ocean water in transoceanic communications.

Fred Hutchinson Cancer Research Center (FHCRC-1): Functional Exploration of the Druggable Genome in MYCN Amplified and Non-amplified Neuroblastoma | Office of Cancer Genomics

Cancer.gov

To identify candidate drugs targets for neuroblastoma with MYCN amplification we performed parallel siRNA screens with a druggable genome collection of ~6,700 genes comparing MYCN amplified and non-MYCN amplified cell lines: SK-N-BE2 (MYCN amplified) and SK-N-AS (non amplified).  The Hits from each cell lines were determined based on their significance with respect to their differential activity in the presence or absence of RA within each cell line.  Hits for each cell line were also ranked according to their P-value, based on the three replicates.  Integration with gene exp

Post pulse shutter for laser amplifier

DOEpatents

Bradley, Laird P. [Livermore, CA; Carder, Bruce M. [Antioch, CA; Gagnon, William L. [Berkeley, CA

1981-03-17

Apparatus and method for quickly closing off the return path for an amplified laser pulse at the output of an amplifier so as to prevent damage to amplifiers and other optical components appearing earlier in the chain by the return of an amplified pulse. The apparatus consists of a fast retropulse or post pulse shutter to suppress target reflection and/or beam return. This is accomplished by either quickly placing a solid across the light transmitting aperture of a component in the chain, such as a spatial filter pinhole, or generating and directing a plasma with sufficiently high density across the aperture, so as to, in effect, close the aperture to the returning amplified energy pulse.

Post pulse shutter for laser amplifier

DOEpatents

Bradley, L.P.; Carder, B.M.; Gagnon, W.L.

1981-03-17

Disclosed are an apparatus and method for quickly closing off the return path for an amplified laser pulse at the output of an amplifier so as to prevent damage to amplifiers and other optical components appearing earlier in the chain by the return of an amplified pulse. The apparatus consists of a fast retropulse or post pulse shutter to suppress target reflection and/or beam return. This is accomplished by either quickly placing a solid across the light transmitting aperture of a component in the chain, such as a spatial filter pinhole, or generating and directing a plasma with sufficiently high density across the aperture, so as to, in effect, close the aperture to the returning amplified energy pulse. 13 figs.

Fred Hutchinson Cancer Research Center (FHCRC1): Functional Landscape of the Human Kinome in MYCN Amplified and Non-amplified Neuroblastoma | Office of Cancer Genomics

Cancer.gov

In order to identify candidate drugs targets that exhibit lethality only in the context of MYCN amplification, we carried out a set of siRNA screens focused on the kinome, targeting ~713 kinases, utilizing human neuroblastoma cells lines with or without MYCN amplification. The neuroblastoma cell lines were: SK-N-BE2 (MYCN amplified) and SK-N-AS (non-amplified).  The kinase Hits for the MYCN amplified cell line were selected using a combination of their differential activity when compared to the non-MYCN amplified cells and also ranked by P-values, based on the replicates.

Fred Hutchinson Cancer Research Center (FHCRC-1): Functional Exploration of the Druggable Genome in MYCN Amplified and Non-amplified Neuroblastoma | Office of Cancer Genomics

Cancer.gov

To identify candidate drugs targets for neuroblastoma with MYCN amplification we performed parallel siRNA screens with a druggable genome collection of ~6,700 genes comparing MYCN amplified and non-MYCN amplified cell lines: SK-N-BE2 (MYCN amplified) and SK-N-AS (non amplified). The Hits from each cell lines were determined based on their significance with respect to their differential activity in the presence or absence of RA within each cell line. Hits for each cell line were also ranked according to their P-value, based on the three replicates. Integration with gene expres

Fred Hutchinson Cancer Research Center (FHCRC-1): Functional Landscape of the Human Kinome in MYCN Amplified and Non-amplified Neuroblastoma | Office of Cancer Genomics

Cancer.gov

In order to identify candidate drugs targets that exhibit lethality only in the context of MYCN amplification, we carried out a set of siRNA screens focused on the kinome, targeting ~713 kinases, utilizing human neuroblastoma cells lines with or without MYCN amplification. The neuroblastoma cell lines were: SK-N-BE2 (MYCN amplified) and SK-N-AS (non-amplified). The kinase Hits for the MYCN amplified cell line were selected using a combination of their differential activity when compared to the non-MYCN amplified cells and also ranked by P-values, based on the replicates.

Double-pass tapered amplifier diode laser with an output power of 1 W for an injection power of only 200 μW.

PubMed

Bolpasi, V; von Klitzing, W

2010-11-01

A 1 W tapered amplifier requiring only 200 μW of injection power at 780 nm is presented in this paper. This is achieved by injecting the seeding light into the amplifier from its tapered side and feeding the amplified light back into the small side. The amplified spontaneous emission of the tapered amplifier is suppressed by 75 dB. The double-passed tapered laser, presented here, is extremely stable and reliable. The output beam remains well coupled to the optical fiber for a timescale of months, whereas the injection of the seed light did not require realignment for over a year of daily operation.

Direct solar-pumped iodine laser amplifier

NASA Technical Reports Server (NTRS)

Han, K. S.

1986-01-01

During this period the parametric studies of the iodine laser oscillator pumped by a Vortek simulator were carried out before amplifier studies. The amplifier studies are postponed to the extended period after completing the parametric studies. In addition, the kinetic modeling of a solar-pumped iodine laser amplifier, and the experimental work for a solar pumped dye laser amplifier are in progress. This report contains three parts: (1) a 10 W CW iodine laser pumped by a Vortek solar simulator; (2) kinetic modeling to predict the time to lasing threshold, lasing time, and energy output of solar-pumped iodine laser; and (3) the study of the dye laser amplifier pumped by a Tamarack solar simulator.

Combination ring cavity and backward Raman waveguide amplifier

DOEpatents

Kurnit, Norman A.

1983-01-01

A combination regenerative ring and backward Raman waveguide amplifier and a combination regenerative ring oscillator and backward Raman waveguide amplifier which produce Raman amplification, pulse compression, and efficient energy extraction from the CO.sub.2 laser pump signal for conversion into a Stokes radiation signal. The ring cavity configuration allows the CO.sub.2 laser pump signal and Stokes signal to copropagate through the Raman waveguide amplifier. The backward Raman waveguide amplifier configuration extracts a major portion of the remaining energy from the CO.sub.2 laser pump signal for conversion to Stokes radiation. Additionally, the backward Raman amplifier configuration produces a Stokes radiation signal which has a high intensity and a short duration. Adjustment of the position of overlap of the Stokes signal and the CO.sub.2 laser pump signal in the backward Raman waveguide amplifiers alters the amount of pulse compression which can be achieved.

Crystal oscillators using negative voltage gain, single pole response amplifiers

NASA Technical Reports Server (NTRS)

Kleinberg, Leonard L. (Inventor)

1989-01-01

A simple and inexpensive crystal oscillator is provided which employs negative voltage gain, single pole response amplifiers. The amplifiers may include such configurations as gate inverters, operational amplifiers and conventional bipolar transistor amplifiers, all of which operate at a frequency which is on the roll-off portion of their gain versus frequency curve. Several amplifier feedback circuit variations are employed to set desired bias levels and to allow the oscillator to operate at the crystal's fundamental frequency or at an overtone of the fundamental frequency. The oscillator is made less expensive than comparable oscillators by employing relatively low frequency amplifiers and operating them at roll-off, at frequencies beyond which they are customarily used. Simplicity is provided because operation at roll-off eliminates components ordinarily required in similar circuits to provide sufficient phase-shift in the feedback circuitry for oscillation to occur.

Beam quality management by periodic reproduction of wavefront aberrations in end-pumped Nd:YVO₄ laser amplifiers.

PubMed

Liu, Bin; Liu, Chong; Shen, Lifeng; Wang, Chunhua; Ye, Zhibin; Liu, Dong; Xiang, Zhen

2016-04-18

A method for beam quality management is presented in a master oscillator power amplifier (MOPA) using Nd:YVO₄ as the gain medium by extra-cavity periodic reproduction of wavefront aberrations. The wavefront aberration evolution of the intra-cavity beams is investigated for both symmetrical and asymmetrical resonators. The wavefront aberration reproduction process is successfully realized outside the cavity in four-stage amplifiers. In the MOPA with a symmetrical oscillator, the laser power increases linearly and the beam quality hardly changes. In the MOPA with an asymmetrical oscillator, the beam quality is deteriorated after the odd-stage amplifier and is improved after the even-stage amplifier. The wavefront aberration reproduction during the extra-cavity beam propagation in the amplifiers is equivalent to that during the intra-cavity propagation. This solution helps to achieve the effective beam quality management in laser amplifier chains.

Addressing Institutional Amplifiers in the Dynamics and Control of Tuberculosis Epidemics

PubMed Central

Basu, Sanjay; Stuckler, David; McKee, Martin

2011-01-01

Tuberculosis outbreaks originating in prisons, mines, or hospital wards can spread to the larger community. Recent proposals have targeted these high-transmission institutional amplifiers by improving case detection, treatment, or reducing the size of the exposed population. However, what effects these alternative proposals may have is unclear. We mathematically modeled these control strategies and found case detection and treatment methods insufficient in addressing epidemics involving common types of institutional amplifiers. Movement of persons in and out of amplifiers fundamentally altered the transmission dynamics of tuberculosis in a manner not effectively mitigated by detection or treatment alone. Policies increasing the population size exposed to amplifiers or the per-person duration of exposure within amplifiers potentially worsened incidence, even in settings with high rates of detection and treatment success. However, reducing the total population size entering institutional amplifiers significantly lowered tuberculosis incidence and the risk of propagating new drug-resistant tuberculosis strains. PMID:21212197

High dynamic range charge measurements

DOEpatents

De Geronimo, Gianluigi

2012-09-04

A charge amplifier for use in radiation sensing includes an amplifier, at least one switch, and at least one capacitor. The switch selectively couples the input of the switch to one of at least two voltages. The capacitor is electrically coupled in series between the input of the amplifier and the input of the switch. The capacitor is electrically coupled to the input of the amplifier without a switch coupled therebetween. A method of measuring charge in radiation sensing includes selectively diverting charge from an input of an amplifier to an input of at least one capacitor by selectively coupling an output of the at least one capacitor to one of at least two voltages. The input of the at least one capacitor is operatively coupled to the input of the amplifier without a switch coupled therebetween. The method also includes calculating a total charge based on a sum of the amplified charge and the diverted charge.

Multi-channel temperature measurement amplification system. [solar heating systems

NASA Technical Reports Server (NTRS)

Currie, J. R. (Inventor)

1981-01-01

A number of differential outputs of thermocouples are sequentially amplified by a common amplifier. The amplified outputs are compared with a reference temperature signal in an offset correction amplifier, and a particularly poled output signal is provided when a differential output is of a discrete level compared with a reference temperature signal.

Low noise charge ramp electrometer

DOEpatents

Morgan, John P.; Piper, Thomas C.

1992-01-01

An electrometer capable of measuring small currents without the use of a feedback resistor which tends to contribute a large noise factor to the measured data. The electrometer eliminates the feedback resistor through the use of a feedback capacitor located across the electrometer amplifier. The signal from the electrometer amplifier is transferred to a electrometer buffer amplifier which serves to transfer the signal to several receptors. If the electrometer amplifier is approaching saturation, the buffer amplifier signals a reset discriminator which energizes a coil whose magnetic field closes a magnetic relay switch which in turn resets or zeros the feedback capacitor. In turn, a reset complete discriminator restarts the measurement process when the electrometer amplifier approaches its initial condition. The buffer amplifier also transmits the voltage signal from the electrometer amplifier to a voltage-to-frequency converter. The signals from the voltage-to-frequency converter are counted over a fixed period of time and the information is relayed to a data processor. The timing and sequencing of the small current measuring system is under the control of a sequence control logic unit.

Low noise charge ramp electrometer

DOEpatents

Morgan, J.P.; Piper, T.C.

1992-10-06

An electrometer capable of measuring small currents without the use of a feedback resistor which tends to contribute a large noise factor to the measured data. The electrometer eliminates the feedback resistor through the use of a feedback capacitor located across the electrometer amplifier. The signal from the electrometer amplifier is transferred to a electrometer buffer amplifier which serves to transfer the signal to several receptors. If the electrometer amplifier is approaching saturation, the buffer amplifier signals a reset discriminator which energizes a coil whose magnetic field closes a magnetic relay switch which in turn resets or zeros the feedback capacitor. In turn, a reset complete discriminator restarts the measurement process when the electrometer amplifier approaches its initial condition. The buffer amplifier also transmits the voltage signal from the electrometer amplifier to a voltage-to-frequency converter. The signals from the voltage-to-frequency converter are counted over a fixed period of time and the information is relayed to a data processor. The timing and sequencing of the small current measuring system is under the control of a sequence control logic unit. 2 figs.

Nd:YLF laser for airborne/spaceborne laser ranging

NASA Technical Reports Server (NTRS)

Dallas, Joseph L.; Selker, Mark D.

1993-01-01

In order to meet the need for light weight, long lifetime, efficient, short pulse lasers, a diode-pumped, Nd:YLF oscillator and regenerative amplifier is being developed. The anticipated output is 20 mJ per 10 picosecond pulse, running at a repetition rate of 40 Hz. The fundamental wavelength is at 1047 nm. The oscillator is pumped by a single laser diode bar and mode locked using an electro-optic, intra-cavity phase modulator. The output from the oscillator is injected as a seed into the regenerative amplifier. The regenerative amplifier laser crystal is optically pumped by two 60W quasi-cw laser diode bars. Each diode is collimated using a custom designed micro-lens bar. The injected 10 ps pulse from the oscillator is kept circulating within the regenerative amplifier until this nanojoule level seed pulse is amplified to 2-3 millijoules. At this point the pulse is ejected and sent on to a more standard single pass amplifier where the energy is boosted to 20 mJ. The footprint of the entire laser (oscillator-regenerative amplifier-amplifier) will fit on a 3 by 4 ft. optical pallet.

93-133 GHz Band InP High-Electron-Mobility Transistor Amplifier with Gain-Enhanced Topology

NASA Astrophysics Data System (ADS)

Sato, Masaru; Shiba, Shoichi; Matsumura, Hiroshi; Takahashi, Tsuyoshi; Nakasha, Yasuhiro; Suzuki, Toshihide; Hara, Naoki

2013-04-01

In this study, we developed a new type of high-frequency amplifier topology using 75-nm-gate-length InP-based high-electron-mobility transistors (InP HEMTs). To enhance the gain for a wide frequency range, a common-source common-gate hybrid amplifier topology was proposed. A transformer-based balun placed at the input of the amplifier generates differential signals, which are fed to the gate and source terminals of the transistor. The amplified signal is outputted at the drain node. The simulation results show that the hybrid topology exhibits a higher gain from 90 to 140 GHz than that of the conventional common-source or common-gate amplifier. The two-stage amplifier fabricated using the topology exhibits a small signal gain of 12 dB and a 3-dB bandwidth of 40 GHz (93-133 GHz), which is the largest bandwidth and the second highest gain reported among those of published 120-GHz-band amplifiers. In addition, the measured noise figure was 5 dB from 90 to 100 GHz.

Cross-talk free, low-noise optical amplifier

DOEpatents

Dijaili, Sol P.; Patterson, Frank G.; Deri, Robert J.

1995-01-01

A low-noise optical amplifier solves crosstalk problems in optical amplifiers by using an optical cavity oriented off-axis (e.g. perpendicular) to the direction of a signal amplified by the gain medium of the optical amplifier. Several devices are used to suppress parasitic lasing of these types of structures. The parasitic lasing causes the gain of these structures to be practically unusable. The lasing cavity is operated above threshold and the gain of the laser is clamped to overcome the losses of the cavity. Any increase in pumping causes the lasing power to increase. The clamping action of the gain greatly reduces crosstalk due to gain saturation for the amplified signal beam. It also reduces other nonlinearities associated with the gain medium such as four-wave mixing induced crosstalk. This clamping action can occur for a bandwidth defined by the speed of the laser cavity. The lasing field also reduces the response time of the gain medium. By having the lasing field off-axis, no special coatings are needed. Other advantages are that the lasing field is easily separated from the amplified signal and the carrier grating fluctuations induced by four-wave mixing are decreased. Two related methods reduce the amplified spontaneous emission power without sacrificing the gain of the optical amplifier.

Cross-talk free, low-noise optical amplifier

DOEpatents

Dijaili, S.P.; Patterson, F.G.; Deri, R.J.

1995-07-25

A low-noise optical amplifier solves crosstalk problems in optical amplifiers by using an optical cavity oriented off-axis (e.g. perpendicular) to the direction of a signal amplified by the gain medium of the optical amplifier. Several devices are used to suppress parasitic lasing of these types of structures. The parasitic lasing causes the gain of these structures to be practically unusable. The lasing cavity is operated above threshold and the gain of the laser is clamped to overcome the losses of the cavity. Any increase in pumping causes the lasing power to increase. The clamping action of the gain greatly reduces crosstalk due to gain saturation for the amplified signal beam. It also reduces other nonlinearities associated with the gain medium such as four-wave mixing induced crosstalk. This clamping action can occur for a bandwidth defined by the speed of the laser cavity. The lasing field also reduces the response time of the gain medium. By having the lasing field off-axis, no special coatings are needed. Other advantages are that the lasing field is easily separated from the amplified signal and the carrier grating fluctuations induced by four-wave mixing are decreased. Two related methods reduce the amplified spontaneous emission power without sacrificing the gain of the optical amplifier. 11 figs.

Ku-band high efficiency GaAs MMIC power amplifiers

NASA Technical Reports Server (NTRS)

Tserng, H. Q.; Witkowski, L. C.; Wurtele, M.; Saunier, Paul

1988-01-01

The development of Ku-band high efficiency GaAs MMIC power amplifiers is examined. Three amplifier modules operating over the 13 to 15 GHz frequency range are to be developed. The first MMIC is a 1 W variable power amplifier (VPA) with 35 percent efficiency. On-chip digital gain control is to be provided. The second MMIC is a medium power amplifier (MPA) with an output power goal of 1 W and 40 percent power-added efficiency. The third MMIC is a high power amplifier (HPA) with 4 W output power goal and 40 percent power-added efficiency. An output power of 0.36 W/mm with 49 percent efficiency was obtained on an ion implanted single gate MESFET at 15 GHz. On a dual gate MESFET, an output power of 0.42 W/mm with 27 percent efficiency was obtained. A mask set was designed that includes single stage, two stage, and three stage single gate amplifiers. A single stage 600 micron amplifier produced 0.4 W/mm output power with 40 percent efficiency at 14 GHz. A four stage dual gate amplifier generated 500 mW of output power with 20 dB gain at 17 GHz. A four-bit digital-to-analog converter was designed and fabricated which has an output swing of -3 V to +/- 1 V.

Optimisation of cascaded Yb fiber amplifier chains using numerical-modelling

NASA Astrophysics Data System (ADS)

He, F.; Price, J. H.; Vu, K. T.; Malinowski, A.; Sahu, J. K.; Richardson, D. J.

2006-12-01

We show that it is possible to adapt existing software packages developed originally for modeling telecommunication devices and systems to reliably predict and optimize the performance of high-power Ytterbium-doped fiber amplifier and laser systems. The ready availability of a flexible, user-friendly design tool should be of considerable practical interest to scientists and engineers working with this important new laser technology since Ytterbium amplifier and amplifier cascades are often difficult to optimize experimentally due to the three-level nature of the Ytterbium laser transition. As examples of the utility and accuracy of the software, as well as the complexity of the systems and amplifier properties that can be successfully modeled, we present a comparison of experimental and theoretical results for individual core and cladding pumped amplifiers, and also for an ultra-short pulse four-stage amplifier system optimized both to provide a broad gain bandwidth and to minimize nonlinear effects. We also show how high energy 100 ns pulses with complex user definable temporal profiles can be created in a gain-saturated amplifier by suitable pre-shaping of the low-energy input pulses. Furthermore, with appropriate modifications the same software package can be applied to fiber amplifiers based on other rare-earth elements and glass hosts.

Design of signal reception and processing system of embedded ultrasonic endoscope

NASA Astrophysics Data System (ADS)

Li, Ming; Yu, Feng; Zhang, Ruiqiang; Li, Yan; Chen, Xiaodong; Yu, Daoyin

2009-11-01

Embedded Ultrasonic Endoscope, based on embedded microprocessor and embedded real-time operating system, sends a micro ultrasonic probe into coelom through the biopsy channel of the Electronic Endoscope to get the fault histology features of digestive organs by rotary scanning, and acquires the pictures of the alimentary canal mucosal surface. At the same time, ultrasonic signals are processed by signal reception and processing system, forming images of the full histology of the digestive organs. Signal Reception and Processing System is an important component of Embedded Ultrasonic Endoscope. However, the traditional design, using multi-level amplifiers and special digital processing circuits to implement signal reception and processing, is no longer satisfying the standards of high-performance, miniaturization and low power requirements that embedded system requires, and as a result of the high noise that multi-level amplifier brought, the extraction of small signal becomes hard. Therefore, this paper presents a method of signal reception and processing based on double variable gain amplifier and FPGA, increasing the flexibility and dynamic range of the Signal Reception and Processing System, improving system noise level, and reducing power consumption. Finally, we set up the embedded experiment system, using a transducer with the center frequency of 8MHz to scan membrane samples, and display the image of ultrasonic echo reflected by each layer of membrane, with a frame rate of 5Hz, verifying the correctness of the system.

A cationic conjugated polymer and graphene oxide: Application to amplified fluorescence detection of sinapine.

PubMed

Zhang, Zhen; Xiang, Xia; Shi, Jianbin; Huang, Fenghong; Xia, Xiaoyang; Zheng, Mingming; Han, Ling; Tang, Hu

2018-10-05

An amplified fluorescence strategy is described for the detection of sinapine (SP) by using a cationic conjugated polymer (PFP) and graphene oxide (GO). It is observed that the fluorescein (FAM)-labeled single-stranded DNA (FAM-DNA) is absorbed on the surface of GO if SP is absent. This causes that fluorescence resonance energy transfer (FRET) from PFP to FAM is inefficient when adding PFP into FAM-DNA/GO complex. If SP is added to FAM-DNA/GO complex, FAM-DNA is desorbed from GO surface due to the competitive binding of SP and FAM-DNA toward GO. In this case, FAM-DNA is close to PFP in the presence of PFP through strong electrostatic interaction, leading to the occurrence of efficient FRET. Based on the above phenomenon, we demonstrate a method to amplify fluorescence signal of traditional GO-based SP assay by introducing PFP. In comparison to the use of single GO, the combination of PFP with GO-based strategy displays high turn-on ratio and enhanced sensitivity with a limit of detection as low as 7.3 ng mL -1 for SP detection. Satisfactory results in practical samples are also obtained by the recovery experiments, demonstrating the potential application of cationic conjugated polymer in plant-derived small molecule. Copyright © 2018 Elsevier B.V. All rights reserved.

Novel fiber-MOPA-based high power blue laser

NASA Astrophysics Data System (ADS)

Engin, Doruk; Fouron, Jean-Luc; Chen, Youming; Huffman, Andromeda; Fitzpatrick, Fran; Burnham, Ralph; Gupta, Shantanu

2012-06-01

5W peak power at 911 nm is demonstrated with a pulsed Neodymium (Nd) doped fiber master oscillator power amplifier (MOPA). This result is the first reported high gain (16dB) fiber amplifier operation at 911nm. Pulse repetition frequency (PRF) and duty-cycle dependence of the all fiber system is characterized. Negligible performance degreadation is observed down to 1% duty cycle and 10 kHz PRF, where 2.5μJ of pulse energy is achieved. Continuous wave (CW) MOPA experiments achieved 55mW average power and 9dB gain with 15% optical to optical (o-o) efficiency. Excellent agreement is established between dynammic fiber MOPA simulation tool and experimental results in predicting output amplified spontaneous emission (ase) and signal pulse shapes. Using the simulation tool robust Stimulated Brillion Scattering (SBS) free operation is predicted out of a two stage all fiber system that generates over 10W's of peak power with 500 MHz line-width. An all fiber 911 nm pulsed laser source with >10W of peak power is expected to increase reliability and reduce complexity of high energy 455 nm laser system based on optical parametric amplification for udnerwater applications. The views expressed are thos of the author and do not reflect the official policy or position of the Department of Defense or the U.S. Government.

Anti-saturation system for surface nuclear magnetic resonance in efficient groundwater detection

NASA Astrophysics Data System (ADS)

Lin, Jun; Zhang, Yang; Yang, Yujing; Sun, Yong; Lin, Tingting

2017-06-01

Compared to other geophysical techniques, the surface nuclear magnetic resonance (SNMR) method could provide unique insights into the hydrologic properties of groundwater in the subsurface. However, the SNMR signal is in the order of nanovolts (10-9 V), and the complex environmental noise, i.e., the spike and the harmony noise (10-4 V), can reach up to 105 times the signal amplitude. Saturation of the amplifier is therefore a serious problem in current SNMR systems. In this study, we propose an anti-saturation method based on an instantaneous floating-point amplifier. The gain of a programmable amplifier is controlled by the value of the input signal. A regulating speed of 50 kS/s is thus achieved to satisfy the self-adaptive adjustment of the real-time SNMR system, which replaces the original man-made setting gain. A large dynamic range of 192.65 dB with a 24-bit high speed analog-digital converter module is then implemented. Compared to traditional SNMR instruments, whose magnification factor is fixed during the experiment, our system can effectively inhibit the distortion of the SNMR signal in both laboratory and field settings. Furthermore, an improved SNR, which is realized by the real-time SNMR system, enables the accurate inversion of the aquifer. Our study broadens the applicability of SNMR systems to use in and around developed areas.

A flexible master oscillator for a pulse-burst laser system

NASA Astrophysics Data System (ADS)

Den Hartog, D. J.; Young, W. C.

2015-12-01

A new master oscillator is being installed in the pulse-burst laser system used for high-rep-rate Thomson scattering on the MST experiment. This new master oscillator will enable pulse repetition rates up to 1 MHz, with the ability to program a burst of pulses with arbitrary and varying time separation between each pulse. In addition, the energy of each master oscillator pulse can be adjusted to compensate for gain variations in the power amplifier section of the laser system. This flexibility is accomplished by chopping a CW laser source with a high-bandwidth acousto-optic modulator (AOM). The laser source is a Laser Quantum ventus 1064 diode-pumped solid-state laser with continuous output power variable from 100 to 500 mW. The 1064 nm, 2.7 mm diameter polarized beam is focused into the gallium phosphide crystal of a Brimrose AOM, which deflects the beam by approximately 60 mR when driven by the 400 MHz fixed frequency driver. Beam deflection is controlled by a simple digital input pulse, and is capable of producing deflected pulses of less than 20 ns width at repetition rates much greater than 1 MHz. These deflected pulses from the output of the AOM are collimated and propagated into the laser amplifier system, where they will be amplified to ~ 2 J/pulse and injected into the MST plasma.

High power, high contrast hybrid femtosecond laser systems

NASA Astrophysics Data System (ADS)

Dabu, Razvan

2017-06-01

For many research applications a very high laser intensity of more than 1022 W/cm2 in the focused beam is required. If a laser intensity of about 1011W/cm2 is reached on the target before the main laser pulse, the generated pre-plasma disturbs the experiment. High power femtosecond lasers must be tightly focused to get high intensity and in the same time must have a high enough intensity contrast of the temporally compressed amplified pulses. Reaching an intensity contrast in the range of 1012 represents a challenging task for a Ti:sapphire CPA laser. Hybrid femtosecond lasers combine optical parametric chirped pulsed amplification (OPCPA) in nonlinear crystals with the chirped pulse amplification (CPA) in laser active media. OPCPA provides large amplification spectral bandwidth and improves the intensity contrast of the amplified pulses. A key feature of these systems consists in the adaptation of the parametric amplification phase-matching bandwidth of nonlinear crystals to the spectral gain bandwidth of laser amplifying Ti:sapphire crystals. OPCPA in BBO crystals up to mJ energy level in the laser Front-End, followed by CPA up to ten/hundred Joules in large aperture Ti:sapphire crystals, represents a suitable solution for PW-class femtosecond lasers. The configuration and expected output beam characteristics of the hybrid amplification 2 × 10 PW ELI-NP laser are described.

Gain equalization in cascaded optical amplifiers using short-period Bragg gratings

NASA Astrophysics Data System (ADS)

Rochette, Martin; Cortes, Pierre-Yves; Guy, Martin; LaRochelle, Sophie; Trepanier, Francois; Lauzon, Jocelyn

2000-12-01

Gain equalization of an amplifier is performed by introducing spectrally designed Bragg gratings in the mid-stage of a dual-stage erbium-doped fiber amplifier. The long-haul performances of the amplifier are evaluated using a 50 km recirculating loop. The results show a clear improvement of the transmission quality when equalizing the gain.

Solid state, S-band, power amplifier

NASA Technical Reports Server (NTRS)

Digrindakis, M.

1973-01-01

The final design and specifications for a solid state, S-band, power amplifier is reported. Modifications from a previously proposed design were incorporated to improve efficiency and meet input overdrive and noise floor requirements. Reports on the system design, driver amplifier, power amplifier, and voltage and current limiter are included along with a discussion of the testing program.

High average power scaling of optical parametric amplification through cascaded difference-frequency generators

DOEpatents

Jovanovic, Igor; Comaskey, Brian J.

2004-09-14

A first pump pulse and a signal pulse are injected into a first optical parametric amplifier. This produces a first amplified signal pulse. At least one additional pump pulse and the first amplified signal pulse are injected into at least one additional optical parametric amplifier producing an increased power coherent optical pulse.

Improved-Bandwidth Transimpedance Amplifier

NASA Technical Reports Server (NTRS)

Chapsky, Jacob

2009-01-01

The widest available operational amplifier, with the best voltage and current noise characteristics, is considered for transimpedance amplifier (TIA) applications where wide bandwidth is required to handle fast rising input signals (as for time-of-flight measurement cases). The added amplifier inside the TIA feedback loop can be configured to have slightly lower voltage gain than the bandwidth reduction factor.

Ultrafast Laser Techniques

DTIC Science & Technology

1991-06-05

2 Prism Dye Amplifiers .................................................................................. 2 Axicon...carried out under this project. PRISM DYE AMPLIFIERS A first effort was devoted to setting up an amplifier system for the output of a short pulse dye laser...For amplification up to pulse energies of approximately 500 p.J/pulse we chose three stages of prism amplifier cells, with diameters of 1 m, 3 mm

Multiple pass laser amplifier system

DOEpatents

Brueckner, Keith A.; Jorna, Siebe; Moncur, N. Kent

1977-01-01

A laser amplification method for increasing the energy extraction efficiency from laser amplifiers while reducing the energy flux that passes through a flux limited system which includes apparatus for decomposing a linearly polarized light beam into multiple components, passing the components through an amplifier in delayed time sequence and recombining the amplified components into an in phase linearly polarized beam.

Differential transimpedance amplifier circuit for correlated differential amplification

DOEpatents

Gresham, Christopher A [Albuquerque, NM; Denton, M Bonner [Tucson, AZ; Sperline, Roger P [Tucson, AZ

2008-07-22

A differential transimpedance amplifier circuit for correlated differential amplification. The amplifier circuit increase electronic signal-to-noise ratios in charge detection circuits designed for the detection of very small quantities of electrical charge and/or very weak electromagnetic waves. A differential, integrating capacitive transimpedance amplifier integrated circuit comprising capacitor feedback loops performs time-correlated subtraction of noise.

Log amplifier with pole-zero compensation

DOEpatents

Brookshier, W.

1985-02-08

A logarithmic amplifier circuit provides pole-zero compensation for improved stability and response time over 6-8 decades of input signal frequency. The amplifer circuit includes a first operational amplifier with a first feedback loop which includes a second, inverting operational amplifier in a second feedstock loop. The compensated output signal is provided by the second operational amplifier with the log elements, i.e., resistors, and the compensating capacitors in each of the feedback loops having equal values so that each break point is offset by a compensating break point or zero.

Low noise parametric amplifiers for radio astronomy observations at 18-21 cm wavelength

NASA Technical Reports Server (NTRS)

Kanevskiy, B. Z.; Veselov, V. M.; Strukov, I. A.; Etkin, V. S.

1974-01-01

The principle characteristics and use of SHF parametric amplifiers for radiometer input devices are explored. Balanced parametric amplifiers (BPA) are considered as the SHF signal amplifiers allowing production of the amplifier circuit without a special filter to achieve decoupling. Formulas to calculate the basic parameters of a BPA are given. A modulator based on coaxial lines is discussed as the input element of the SHF. Results of laboratory tests of the receiver section and long-term stability studies of the SHF sector are presented.

Compact laser amplifier system

DOEpatents

Carr, R.B.

1974-02-26

A compact laser amplifier system is described in which a plurality of face-pumped annular disks, aligned along a common axis, independently radially amplify a stimulating light pulse. Partially reflective or lasing means, coaxially positioned at the center of each annualar disk, radially deflects a stimulating light directed down the common axis uniformly into each disk for amplification, such that the light is amplified by the disks in a parallel manner. Circumferential reflecting means coaxially disposed around each disk directs amplified light emission, either toward a common point or in a common direction. (Official Gazette)

A 160 W single-frequency laser based on an active tapered double-clad fiber amplifier

NASA Astrophysics Data System (ADS)

Trikshev, A. I.; Kurkov, A. S.; Tsvetkov, V. B.; Filatova, S. A.; Kertulla, J.; Filippov, V.; Chamorovskiy, Yu K.; Okhotnikov, O. G.

2013-06-01

We present a CW single-frequency laser at 1062 nm (linewidth <3 MHz) with 160 W of total output power based on a two stage fiber amplifier. A GTWave fiber is used for the first stage of the amplifier. A tapered double-clad fiber (T-DCF) is used for the second stage of the amplifier. The high output power is achieved due to the amplified spontaneous emission (ASE) filtering and increased stimulated Brillouin scattering (SBS) threshold inherent to the axially non-uniform geometry.

Method and apparatus for the measurement of signals from radiation sensors

DOEpatents

De Geronimo, Gianluigi

2012-09-18

The preferred embodiments of the present invention include a device for measuring an ionizing event in a radiation sensor. The device can include a charge amplifier and a timing shaper. The charge amplifier receives a cathode signal and is configured to output an amplified cathode signal. The timing shaper is operatively connected to the charge amplifier to receive the amplified cathode signal. The timing shaper is configured to generate a first pulse in response to a beginning of the ionizing event and a second pulse in response to an end of the ionizing event. The first and second pulses are associated with a depth of interaction of the ionizing event and are generated in response to a slope of the amplified cathode signal changing.

Power oscillator

DOEpatents

Gitsevich, Aleksandr

2001-01-01

An oscillator includes an amplifier having an input and an output, and an impedance transformation network connected between the input of the amplifier and the output of the amplifier, wherein the impedance transformation network is configured to provide suitable positive feedback from the output of the amplifier to the input of the amplifier to initiate and sustain an oscillating condition, and wherein the impedance transformation network is configured to protect the input of the amplifier from a destructive feedback signal. One example of the oscillator is a single active element device capable of providing over 70 watts of power at over 70% efficiency. Various control circuits may be employed to match the driving frequency of the oscillator to a plurality of tuning states of the lamp.