ARC-2006-ACD06-0216-017

NASA Image and Video Library

2006-11-29

Stardust sample analysis @ UC Berkeley clean room with Dr Scott Sandford, NASA Ames Astrophysicist - mission samples provided to UC Berkeley for analysis by NASABerkeley researcher Zack Gainsforth working with sample encased in aerogel

ARC-2006-ACD06-0216-022

NASA Image and Video Library

2006-11-29

Stardust sample analysis @ UC Berkeley clean room with Dr Scott Sandford, NASA Ames Astrophysicist - mission samples provided to UC Berkeley for analysis by NASABerkeley researcher Zack Gainsforth working with sample encased in aerogel

Trading Carbon: Can Cookstoves Light the Way (LBNL Science at the Theater)

ScienceCinema

Gadgil, Ashok; Booker, Kayje; Rausch, Adam

2018-06-08

Science at the Theater: Get smart about carbon! Learn how families in Africa, using stoves designed by Berkeley Lab, are at the forefront of global carbon reduction. Ashok Gadgil is the driving force behind the Berkeley-Darfur Cookstove. He is a researcher, inventor, renowned humanitarian, and director of Berkeley Lab's Environmental Energy Technologies Division. Kayje Booker is a Berkeley Lab researcher and UC Berkeley graduate student in ecosystem sciences. She is exploring how carbon markets can serve as catalysts for innovation in technologies for the poor. Adam Rausch is a Berkeley Lab researcher and UC Berkeley graduate student in civil environmental engineering. He helps to design and test stove designs in Ethiopia and elsewhere.

LBNL Computational ResearchTheory Facility Groundbreaking - Full Press Conference. Feb 1st, 2012

ScienceCinema

Yelick, Kathy

2018-01-24

Energy Secretary Steven Chu, along with Berkeley Lab and UC leaders, broke ground on the Lab's Computational Research and Theory (CRT) facility yesterday. The CRT will be at the forefront of high-performance supercomputing research and be DOE's most efficient facility of its kind. Joining Secretary Chu as speakers were Lab Director Paul Alivisatos, UC President Mark Yudof, Office of Science Director Bill Brinkman, and UC Berkeley Chancellor Robert Birgeneau. The festivities were emceed by Associate Lab Director for Computing Sciences, Kathy Yelick, and Berkeley Mayor Tom Bates joined in the shovel ceremony.

LBNL Computational Research and Theory Facility Groundbreaking. February 1st, 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yelick, Kathy

2012-02-02

Energy Secretary Steven Chu, along with Berkeley Lab and UC leaders, broke ground on the Lab's Computational Research and Theory (CRT) facility yesterday. The CRT will be at the forefront of high-performance supercomputing research and be DOE's most efficient facility of its kind. Joining Secretary Chu as speakers were Lab Director Paul Alivisatos, UC President Mark Yudof, Office of Science Director Bill Brinkman, and UC Berkeley Chancellor Robert Birgeneau. The festivities were emceed by Associate Lab Director for Computing Sciences, Kathy Yelick, and Berkeley Mayor Tom Bates joined in the shovel ceremony.

LBNL Computational Research and Theory Facility Groundbreaking. February 1st, 2012

ScienceCinema

Yelick, Kathy

2017-12-09

Energy Secretary Steven Chu, along with Berkeley Lab and UC leaders, broke ground on the Lab's Computational Research and Theory (CRT) facility yesterday. The CRT will be at the forefront of high-performance supercomputing research and be DOE's most efficient facility of its kind. Joining Secretary Chu as speakers were Lab Director Paul Alivisatos, UC President Mark Yudof, Office of Science Director Bill Brinkman, and UC Berkeley Chancellor Robert Birgeneau. The festivities were emceed by Associate Lab Director for Computing Sciences, Kathy Yelick, and Berkeley Mayor Tom Bates joined in the shovel ceremony.

Trading Carbon: Can Cookstoves Light the Way (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gadgil, Ashok; Booker, Kayje; Rausch, Adam

2010-09-20

Science at the Theater: Get smart about carbon! Learn how families in Africa, using stoves designed by Berkeley Lab, are at the forefront of global carbon reduction. Ashok Gadgil is the driving force behind the Berkeley-Darfur Cookstove. He is a researcher, inventor, renowned humanitarian, and director of Berkeley Lab's Environmental Energy Technologies Division. Kayje Booker is a Berkeley Lab researcher and UC Berkeley graduate student in ecosystem sciences. She is exploring how carbon markets can serve as catalysts for innovation in technologies for the poor. Adam Rausch is a Berkeley Lab researcher and UC Berkeley graduate student in civil environmentalmore » engineering. He helps to design and test stove designs in Ethiopia and elsewhere.« less

Reimagining Educational Research: A Conversation

ERIC Educational Resources Information Center

Carter, Prudence L.; Nasir, Na'ilah Suad

2017-01-01

The following is a transcript of an interview between the Dean of the University of California (UC) Berkeley's Graduate School of Education, Prudence Carter, and UC Berkeley's outgoing Vice Chancellor for Equity and Inclusion, Na'ilah Suad Nasir, recorded at the 2017 Graduate School of Education Research Day.

Expanding Off-Campus Enrollment Capacity at Berkeley: A Concept Paper. Research & Occasional Paper Series: CSHE.2.17

ERIC Educational Resources Information Center

Geiser, Saul

2017-01-01

Like Berkeley, the UC system as a whole is quickly running out of space to accommodate the next generation of Californians who will be reaching college age by mid-century. Even with the added capacity at UC Merced, the UC system will run out of space on existing campuses in the next decade. In the normal course of events, this would trigger…

The Universe Adventure - Help

Science.gov Websites

teachers introduce the material to their students. Clicking the link will open another window with activity ideas or worksheets to download. The number of stars next to the activity name indicates how difficult . Bechtel, Jr. Foundation [ Site Map ] optimized for Firefox [ UC Berkeley ] [ UC Berkeley Physics

In Search of Good Governance

ERIC Educational Resources Information Center

Grush, Mary

2007-01-01

Since his retirement in 2005, UC-Berkeley's Associate Vice Chancellor and CIO Emeritus and current ECAR fellow John (Jack) McCredie has devoted much of his professional energy to studying and writing/speaking about IT governance and leadership in higher education. In his role at UC-Berkeley, he was responsible for leading central IT support for…

UC Berkeley's Celebration of the International Year of Astronomy 2009

NASA Astrophysics Data System (ADS)

Cobb, B. E.; Croft, S.; Silverman, J. M.; Klein, C.; Modjaz, M.

2010-08-01

We present the astronomy outreach efforts undertaken for the International Year of Astronomy 2009 at the University of California, Berkeley. Our department-wide endeavors included a monthly public lecture series by UC Berkeley astronomers and a major astronomy outreach event during a campus-wide university "open house," which included solar observing and a Starlab Planetarium. In addition to sharing our outreach techniques and outcomes, we discuss some of our unique strategies for advertising our events to the local community.

Site Environmental Report for 2011, Volumes 1& 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baskin, David; Bauters, Tim; Borglin, Ned

2012-09-12

The Site Environmental Report for 2011 summarizes Berkeley Lab’s environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year (CY) 2011. Throughout this report, “Berkeley Lab” or “LBNL” refers both to (1) the multiprogram scientific facility the UC manages and operates on the 202-acre university-owned site located in the hills above the UC Berkeley campus, and the site itself, and (2) the UC as managing and operating contractor for Ernest Orlando Lawrence Berkeley National Laboratory. The report is separated into two volumes. Volume I is organized into an executive summary followed by six chapters that includemore » an overview of LBNL, a discussion of its Environmental Management System (EMS), the status of environmental programs, summarized results from surveillance and monitoring activities, and quality assurance (QA) measures. Volume II contains individual data results from surveillance and monitoring activities.« less

Follow the Money: Engineering at Stanford and UC Berkeley during the Rise of Silicon Valley

ERIC Educational Resources Information Center

Adams, Stephen B.

2009-01-01

A comparison of the engineering schools at UC Berkeley and Stanford during the 1940s and 1950s shows that having an excellent academic program is necessary but not sufficient to make a university entrepreneurial (an engine of economic development). Key factors that made Stanford more entrepreneurial than Cal during this period were superior…

Shut out of the System: As Competition Increases for Slots at UC-Berkeley, Admission Offers to Minority Students Continue to Decline

ERIC Educational Resources Information Center

Burdman, Pamela

2004-01-01

As University of California officials announced admissions results for the fall, it appeared that increasing competition for seats at the university, rising tuition costs, and continued controversy over the role of race in admissions were conspiring to reduce the slots offered to African American students at UC-Berkeley. At the same time, the…

Saul Perlmutter

Science.gov Websites

joined the UC Berkeley Physics Department in 2004. He is also an astrophysicist at Lawrence Berkeley Perlmutter won the Department of Energy's E. O. Lawrence Award in Physics. In 2003 he was awarded the

Dark Secrets: What Science Tells Us About the Hidden Universe (LBNL Science at the Theater)

ScienceCinema

Permutter, Saul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)] (ORCID:0000000244364661); Schlegel, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Leauthaud, Alexie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2018-06-12

No mystery is bigger than dark energy - the elusive force that makes up three-quarters of the Universe and is causing it to expand at an accelerating rate. KTVU Channel 2 health and science editor John Fowler will moderate a panel of Lawrence Berkeley National Laboratory scientists who use phenomena such as exploding stars and gravitational lenses to explore the dark cosmos. Saul Perlmutter heads the Supernova Cosmology Project, which pioneered the use of precise observations of exploding stars to study the expansion of the Universe. His international team was one of two groups who independently discovered the amazing phenomenon known as dark energy, and he led a collaboration that designed a satellite to study the nature of this dark force. He is an astrophysicist at Berkeley Lab and a professor of physics at UC Berkeley. David Schlegel is a Berkeley Lab astrophysicist and the principal investigator of Baryon Oscillation Spectroscopic Survey (BOSS), the largest of four night-sky surveys being conducted in the third phase of the Sloan Digital Sky Survey, known as SDSS-III. BOSS will generate a 3-D map of two million galaxies and quasars, using a specially built instrument outfitted with 1,000 optical fibers and mounted on the SDSS telescope in New Mexico. Alexie Leauthaud is Chamberlain Fellow at Berkeley Lab. Her work probes dark matter in the Universe using a technique called gravitational lensing. When gravity from a massive object such as a cluster of galaxies warps space around it, this can distort our view of the light from an even more distant object. The scale and direction of this distortion allows astronomers to directly measure the properties of both dark matter and dark energy.

Excellence in Research: Creative Organizational Responses at Berkeley, Harvard, MIT, and Stanford. ASHE 1985 Annual Meeting Paper.

ERIC Educational Resources Information Center

Gardiner, John J.

Research environments of four leading universities were studied: University of California at Berkeley (UC-Berkeley), Harvard University, Massachusetts Institute of Technology (MIT), and Stanford University. Attention was directed to organizational responses for encouraging collaboration in research at these leading universities, as well as to…

Evaluating the Impact of Open Access at Berkeley: Results from the 2015 Survey of Berkeley Research Impact Initiative (BRII) Funding Recipients

ERIC Educational Resources Information Center

Teplitzky, Samantha; Phillips, Margaret

2016-01-01

The Berkeley Research Impact Initiative (BRII) was one of the first campus-based open access (OA) funds to be established in North America and one of the most active, distributing more than $244,000 to support University of California (UC) Berkeley authors. In April 2015, we conducted a qualitative study of 138 individuals who had received BRII…

Documentation for a web site to serve ULF-EM (Ultra-Low Frequency Electromagnetic) data to the public

USGS Publications Warehouse

Neumann, Danny A.; McPherson, Selwyn; Klemperer, Simon L.; Glen, Jonathan M.G.; McPhee, Darcy K.; Kappler, Karl

2011-01-01

The Stanford Ultra-Low Frequency Electromagnetic (ULF-EM) Monitoring Project is recording naturally varying electromagnetic signals adjacent to active earthquake faults, in an attempt to establish whether there is any variation in these signals associated with earthquakes. Our project is collaborative between Stanford University, the U.S. Geological Survey (USGS), and UC Berkeley. Lead scientists are Simon Klemperer (Stanford University), Jonathan Glen (USGS) and Darcy Karakelian McPhee (USGS). Our initial sites are in the San Francisco Bay Area, monitoring different strands of the San Andreas fault system, at Stanford University's Jasper Ridge Biological Preserve (JRSC), Marin Headlands of the Golden Gate National Recreation Area (MHDL), and the UC Berkeley's Russell Reservation Field Station adjacent to Briones Regional Park (BRIB). In addition, we maintain in conjunction with the Berkeley Seismological Laboratory (BSL) two remote reference stations at the Bear Valley Ranch in Parkfield, Calif., (PKD) and the San Andreas Geophysical Observatory at Hollister, Calif., (SAO). Metadata about our site can be found at http://ulfem-data.stanford.edu/info.html. Site descriptions can be found at the BSL at http://seismo.berkeley.edu/, and seismic data can be obtained from the Northern California Earthquake Data Center at http://www.ncedc.org/. The site http://ulfem-data.stanford.edu/ allows access to data from the Stanford-USGS sites JRSC, MHDL and BRIB, as well as UC Berkeley sites PKD and SAO.

[Greatness and tribulations of Zeiss and Leitz, two famous German optic companies III. Zeiss Ikon and elimination of Emanuel Goldberg].

PubMed

Gilgenkrantz, Simone

2011-05-01

Gathering archival documents to trace the history of the Zeiss company presents no difficulty : they are abundant… except for a period from 1932 to 1945, systematically ignored, and that corresponds to the Nazi period. On the website Zeiss Historica, among the outstanding personalities of the Zeiss company, we note that, for Professor Emanuel Goldberg, the web page « is still under development but an early picture of the professor is available. ». But fortunately, Mickael Buckland, a Professor at the UC Berkeley School of Information brought the life and the work of Emanuel Goldberg to light. Thanks to him, his works and innovations, who had disappeared from our cultural and scientific heritage, return to light after being erased during fifty years. Goldberg had published dozens of articles, obtained patents, developed cameras, microdots, movie cameras, and he designed what he called a "Statistical Machine ", the first electronic document retrieval machine. In France, if this rediscovery was made known to the world of information science, it has not had the impact it deserved in the scientific world. Therefore it is time to reconstruct his career and his work, and to analyse the reasons why some attempted to erase definitively his name and memory. © 2011 médecine/sciences - Inserm / SRMS.

Space Policy Debate - On Space Privatization and Property Rights

NASA Technical Reports Server (NTRS)

Tu, Eugene; Yan, Jerry Chi Yiu

2017-01-01

This presentation is intended to acquaint the audience of UC Berkeley and UC Los Angeles students with the mission of NASA, core competencies at Ames, and to provide a framework for further discussion by students of aeronautics and space sciences.

The Universe Adventure - Credits

Science.gov Websites

Basel), and George Smoot (LBNL) Content, Graphic/Web Design Artie Konrad (student, UC Berkeley) 2004 Berkeley) Laurie Kerrigan (teacher, Mercy High School) Graphic/Web Design Melissa McClure (student ) Graphic/Web Design Paul Higgins (student, Contra Costa College) Other Gordon Aubrecht (Ohio State

NIEHS/EPA CEHCs: Berkeley/Stanford Children's Environment Health Center - UC Berkeley

EPA Pesticide Factsheets

The goal of this Center is to better understand the effects of exposure in the womb to air pollutants and airborne bacteria on newborn health, immune system health during childhood, and to understand the relationship of these early-life exposures to asthma

The Berkeley UNIX Consultant Project

DTIC Science & Technology

1987-08-01

of the National Conference on Artifcial Intelligence . Pittsburgh, PA. (2) Chin, D. N. 1986. User modeling in UC, the UNIX consultant. In Proceedings of...Codes Avalt and I1of Dis Special 1. Introduction Several years ago, we began a project called UC (UNIX Consultant). UC was to function as an intelligent ...English. We sometimes refer to UC as "an intelligent ’help’ facility" to emphasize our intention to construct a consul- tation system, rather than a

Berkeley Lab's Saul Perlmutter wins Nobel Prize in Physics | Berkeley Lab

Science.gov Websites

astrophysics, dark energy, physics Connect twitter instagram LinkedIn facebook youtube This form needs Berkeley Lab's Saul Perlmutter wins Nobel Prize in Physics News Release Paul Preuss 510-486-6249 * October professor of physics at the University of California at Berkeley, has won the 2011 Nobel Prize in Physics

Ting Xu

Science.gov Websites

California, Berkeley tingxu@berkeley.edu 510-642-1632 Research profile » A U.S. Department of Energy National Laboratory Operated by the University of California UC logo Questions & Comments * Privacy Computational Study of Excited-State Phenomena in Energy Materials Center for X-ray Optics MSD Facilities Ion

UC Berkeley's Adaptations to the Crisis of Public Higher Education in the US: Privatization? Commercialization? or Hybridization? Research & Occasional Paper Series: CSHE.17.13

ERIC Educational Resources Information Center

Breslauer, George W.

2013-01-01

The University of California at Berkeley now delivers more to the public of California than it ever has, and it does this on the basis of proportionally less funding by the State government than it has ever received. This claim may come as a surprise, since it is often said that Berkeley is in the process of privatizing, becoming less of a public…

A Proposal to Eliminate the SAT in Berkeley Admissions. Research & Occasional Paper Series: CSHE.4.16

ERIC Educational Resources Information Center

Geiser, Saul

2016-01-01

The SAT is used for two purposes at the University of California. First is "eligibility": Determining whether applicants meet the minimum requirements for admission to the UC system. Second is "admissions selection": At high-demand campuses such as Berkeley, with many more eligible applicants than places available, test scores…

VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY VIEW OF 2401 PIEDMONT, ALPHA EPSILON PHI HOUSE BY RATCLIFF & RATCLIFF, 1958. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM SW CORNER TOWARDS 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. LOOKING NORTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

Doing Much More with Less: Implementing Operational Excellence at UC Berkeley. Research & Occasional Paper Series: CSHE.10.13

ERIC Educational Resources Information Center

Szeri, Andrew J.; Lyons, Richard; Huston, Peggy; Wilton, John

2013-01-01

Universities are undergoing historic change, from the sharp downward shift in government funding to widespread demands to document performance. At the University of California Berkeley, this led to an operational change effort unlike any the university had ever attempted, dubbed Operational Excellence. The authors describe their experiences…

ALTERNATE VIEW OF SIDEWALK AND WALL OF INDIGENOUS VOLCANIC RYOLITE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ALTERNATE VIEW OF SIDEWALK AND WALL OF INDIGENOUS VOLCANIC RYOLITE EASTSIDE OF PIEDMONT AVENUE ADJACENT TO OAK GROVE AND CALIFORNIA MEMORIAL STADIUM. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, June 29, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

Novel Adult Stem Cells for Peripheral Nerve Regeneration

DTIC Science & Technology

2012-09-01

were also positive for MSC surface marker CD29 and CD44 (Fig. 1F-G). However, CD29 and CD44 are also expressed in SMCs, so we will not use these non...tubulin. In addition, MVSCs were negative for perivascular MSC marker CD146 (Fig. 1H) and SMC progenitor marker Sca-1 (Fig. 1I). MVSCs were also...University of California, Berkeley, California 94720, USA. 2 UC Berkeley-UCSF Graduate Program in Bioengineering, Berkeley, California 94720, USA. 3

FIFI: The MPE Garching/UC Berkeley Far-Infrared Imaging Fabry-Perot Interferometer

NASA Technical Reports Server (NTRS)

Geis, Norbert; Genzel, Reinhard; Haggerty, M.; Herrmann, F.; Jackson, J.; Madden, Suzanne C.; Nikola, T.; Poglitsch, Albrecht; Rumitz, M.; Stacey, G. J.

1995-01-01

We describe the performance characteristics of the MPE Garching/UC Berkeley Far-Infrared Imaging Fabry-Perot Interferometer (FIFI) for the Kuiper Airborne Observatory (KAO). The spectrometer features two or three cryogenic tunable Fabry-Perot filters in series giving spectral resolution R of up to 10(exp 5) in the range of 40 microns less than lambda less than 200 microns, and an imaging 5x5 array of photoconductive detectors with variable focal plane plate scale. The instrument works at background limited sensitivity of up to 2 x 10(exp -19) W cm(exp -2) Hz(exp -1/2) per pixel per resolution element at R = 10(exp 5) on the KAO.

DETAIL VIEW OF SIDEWALKS AND TREES ON CHANNING WAY AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF SIDEWALKS AND TREES ON CHANNING WAY AT INTERSECTION OF PIEDMONT AVENUE WITH 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928, LOOKING NW. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM EAST SIDE OF CIRCLE LOOKING NORTH AT 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

Peacebook: A Resource Guide for Peace Studies at U.C. Berkeley, 1982-83 [and] 1983-84.

ERIC Educational Resources Information Center

Peace Studies Student Association.

A series of essays and lists of resource materials as well as courses relevant to peace studies at the University of California Berkeley are presented in the two guides. Topics of the 1982-83 guide include the undergraduate major in Peace and Conflict Studies (PACS), a proposed curriculum, core courses, concentration area courses (social systems,…

Academic productivity and its relationship to physician salaries in the University of California Healthcare System.

PubMed

Fijalkowski, Natalia; Zheng, Luo Luo; Henderson, Michael T; Moshfeghi, Andrew A; Maltenfort, Mitchell; Moshfeghi, Darius M

2013-07-01

To evaluate whether physicians with higher academic productivity, as measured by the number of publications in Scopus and the Scopus Hirsch index (h-index), earn higher salaries. This was a cross-sectional study. Participants were ophthalmologists, otolaryngologists, neurosurgeons, and neurologists classified as "top earners" (>$100,000 annually) within the University of California (UC) healthcare system in 2008. Bibliometric searches on Scopus were conducted to retrieve the total number of publications and Hirsch indices (h-index), a measure of academic productivity. The association between the number of publications and h-index on physicians' total compensation was determined with multivariate regression models after controlling for the four specialties (ophthalmology, otolaryngology, neurosurgery, and neurology), the five institutions (UC San Francisco, UC Los Angeles, UC San Diego, UC Irvine, and UC Davis), and academic rank (assistant professor, associate professor, and professor). The UC healthcare system departments reported 433 faculty physicians among the four specialties, with 71.6% (n = 310) earning more than $100,000 in 2008 and classifying as top earners. After controlling for the specialty, institution, and ranking, there was a significant association between the number of publications on salary (P < 0.000001). Scopus number of publications and h-index were correlated (P < 0.001). Scopus h-index was of borderline significance in predicting physician salary (P = 0.12). Physicians with higher Scopus publications had higher total salaries across all four specialties. Every 10 publications were associated with a 2.40% increase in total salary after controlling for specialty, institution, rank, and chair. Ophthalmologists, otolaryngologists, neurosurgeons, and neurologists in the UC healthcare system who are more academically productive receive greater remuneration.

PART 2 OF 2 PART PANORAMA WITH NO. CA212 VIEW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PART 2 OF 2 PART PANORAMA WITH NO. CA-2-12 VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY WITH 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. SEEN FROM SE CORNER LOOKING NW. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

How Bilayer Graphene Got a Bandgap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng Wang

2009-06-02

Graphene is the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics. But theres a catch: graphene has no bandgap. Now Feng Wang and his colleagues at Berkeley Lab and UC Berkeley have engineered a bandgap in bilayer graphene that can be precisely controlled from 0 to 250 milli-electron volts, which is the energy of infrared radiation.

How Bilayer Graphene Got a Bandgap

ScienceCinema

Feng Wang

2017-12-09

Graphene is the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics. But theres a catch: graphene has no bandgap. Now Feng Wang and his colleagues at Berkeley Lab and UC Berkeley have engineered a bandgap in bilayer graphene that can be precisely controlled from 0 to 250 milli-electron volts, which is the energy of infrared radiation.

How Bilayer Graphene Got a Bandgap

ScienceCinema

Wang, Feng

2018-01-08

Graphene is the two-dimensional crystalline form of carbon, whose extraordinary electron mobility and other unique features hold great promise for nanoscale electronics and photonics. But theres a catch: graphene has no bandgap. Now Feng Wang and his colleagues at Berkeley Lab and UC Berkeley have engineered a bandgap in bilayer graphene that can be precisely controlled from 0 to 250 milli-electron volts, which is the energy of infrared radiation.

Interviews with Exemplary Teachers: Leon F. Litwack.

ERIC Educational Resources Information Center

Rosenzweig, Roy

2001-01-01

Presents an interview with Leon F. Litwack, a professor of U.S. history at the University of California, Berkeley. Covers topics such as what led him to teaching history, his lectures at Berkeley, themes covered in his U.S. history surveys, and his perception of good teaching. (CMK)

Robustness, Diagnostics, Computing and Graphics in Statistics

DTIC Science & Technology

1990-01-01

seto his collection at nuformation. ruciL.ong suggestions for reducing this burden to Washington iieadcuarters Services . Directorate or information...Lewis Cornell University Keaing Lu Georgia Institute of Technology Mary Silber UC, Berkeley Matthew W. Stafford Loyola University Mary Lou Zeeman UC...wavefronts in excitable media are determined by the manner of recovery to the rest state. The distance between a pair of wavefronts tends to lock at one of

Public census data on CD-ROM at Lawrence Berkeley Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merrill, D.W.

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socio-economic and geographic data files which are available to CEDR and PAREP collaborators via LBL`s computing network. At this time 70 CD-ROM diskettes (approximately 36 gigabytes) are on line via the Unix file server cedrcd. lbl. gov. Most of the files are from the US Bureau of the Census, and most pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the formmore » of ASCII text files. Printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), or the UC Documents Library. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user`s application program(s).« less

Public census data on CD-ROM at Lawrence Berkeley Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merrill, D.W.

The Comprehensive Epidemiologic Data Resource (CEDR) and Populations at Risk to Environmental Pollution (PAREP) projects, of the Information and Computing Sciences Division (ICSD) at Lawrence Berkeley Laboratory (LBL), are using public socio-economic and geographic data files which are available to CEDR and PAREP collaborators via LBL's computing network. At this time 70 CD-ROM diskettes (approximately 36 gigabytes) are on line via the Unix file server cedrcd. lbl. gov. Most of the files are from the US Bureau of the Census, and most pertain to the 1990 Census of Population and Housing. All the CD-ROM diskettes contain documentation in the formmore » of ASCII text files. Printed documentation for most files is available for inspection at University of California Data and Technical Assistance (UC DATA), or the UC Documents Library. Many of the CD-ROM diskettes distributed by the Census Bureau contain software for PC compatible computers, for easily accessing the data. Shared access to the data is maintained through a collaboration among the CEDR and PAREP projects at LBL, and UC DATA, and the UC Documents Library. Via the Sun Network File System (NFS), these data can be exported to Internet computers for direct access by the user's application program(s).« less

[Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis].

PubMed

Ning, Li-Qin; Ye, Bai; Shen, Hong; Lu, Wei-Min; Xu, Dan-Hua; Yan, Jing; Tan, Chang; Tang, De-Cai

2018-03-01

Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method. The findings showed that the most frequently used drugs were clearing-heat herbs, which were followed by hemostatic herbs, excreting-dampness herbs, improving-digestion herbs and tonifying-Qi herbs. At the same time, the commonly combined drugs were excavated. Finally, in order to analyze potential molecular targets of the frequently used herbs, GO enrichment analysis and KEGG signal pathway enrichment analysis were performed with bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine (BATMAN-TCM). The results indicated that Chinese herbal compounds may treat UC by activating PPAR-γ pathway and regulating intestinal inflammation. The exact mechanisms shall be verified through subsequent molecular biological experiments. Copyright© by the Chinese Pharmaceutical Association.

SB6.0: The 6th International meeting on Synthetic Biology, July 9-11, 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahl, Linda J.

The Synthetic Biology conference series (SBx.0) is the preeminent academic meeting in synthetic biology. Organized by the BioBricks Foundation, the SBx.0 conference series brings together leading researchers, students, industry executives, and policy makers from around the world to share, consider, debate, and plan efforts to make biology easier to engineer. Historically held every two years, the SBx.0 conferences are held in alternating locations in the United States, Europe, and Asia to encourage global participation and collaboration so that the ramifications of synthetic biology research and development are most likely to be safe ethical, and beneficial. On 9-11 July 2013, themore » 6th installment of the synthetic biology conference series (SB6.0) was held on the campus of Imperial College London (http://sb6.biobricks.org). The SB6.0 conference was attended by over 700 people, and many more were able to participate via video digital conference (http://sb6.biobricks.org/digital-conference/). Over the course of three days, the SB6.0 conference agenda included plenary sessions, workshops, and poster presentations covering topics ranging from the infrastructure needs arising when “Systematic Engineering Meets Biological Complexity” and design-led considerations for “Connecting People and Technologies” to discussions on “Engineering Biology for New Materials,” “Assessing Risk and Managing Biocontainment,” and “New Directions for Energy and Sustainability.” The $10,150 grant awarded by the U.S. Department of Energy (DE-SC0010233) to the BioBricks Foundation was used to provide partial reimbursement for the travel expenses of leading researchers from the United States to speak at the SB6.0 conference. A total of $9,450 was used to reimburse U.S. speakers for actual expenses related to the SB6.0 conference, including airfare (economy or coach only), ground transportation, hotel, and registration fees. In addition, $700 of the grant was used to offset direct administrative costs associated with selecting speakers (preparing announcements, evaluating abstract submissions) and handling travel arrangements. Leading U.S. researchers selected to speak at the SB6.0 conference included: Adam Arkin, Ph.D. Division Director of the Physical Biosciences Division at the Lawrence Berkeley National Laboratory and Professor in the Department of Bioengineering at UC Berkeley Jay Keasling, Ph.D. Professor in the Department of Bioengineering at Berkeley, Senior Faculty Scientist and Associate Laboratory Director of the Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute. Debra Mathews, Ph.D. Assistant Director for Science Programs for the Johns Hopkins Berman Institute of Bioethics, Assistant Professor in the Department of Pediatrics, and Affiliate Faculty in the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine. Richard Murray, Ph.D. Thomas E. and Doris Everhart Professor of Control & Dynamical Systems and Bioengineering at Caltech. Sarah Richardson, Ph.D. Distinguished Postdoctoral Fellow in Genomics at the Lawrence Berkeley National Laboratory and the Department of Energy Joint Genome Institute. and others (for a complete listing of speakers presenting at the SB6.0 conference see http://sb6.biobricks.org/speakers/) The SB6.0 conference was the largest synthetic biology conference to date, and highlights of the SB6.0 conference have been published in a special issue of ACS Synthetic Biology (http://pubs.acs.org/toc/asbcd6/3/3). The BioBricks Foundation appreciates the support of the U.S. Department of Energy in helping to make this most influential and important conference in the field of synthetic biology a success.« less

Evaluation of Chemical and Atmospheric Sciences Research.

DTIC Science & Technology

1987-09-14

of Chemistry Los Alamos National Laboratory The University of California Los Alamwn, New Mexico 87545 Berkeley, California 94720 Professor Dennis H ...The University of Texas, Dallas Professor Richard P. Van Dwyne Richardson, Texas 75080. Department of Chemistry Northwestern University Professor H ...Jamues Harwox Evanston, Illinois 60201 Chairman Institute of Polymer Science Dr. Field H . Winslow University of Akron Bell Laboratories Akron, Chio

MyEEW: A Smartphone App for the ShakeAlert System

NASA Astrophysics Data System (ADS)

Strauss, J. A.; Allen, S.; Allen, R. M.; Hellweg, M.

2015-12-01

Earthquake Early Warning (EEW) is a system that can provide a few to tens of seconds warning prior to ground shaking at a user's location. The goal and purpose of such a system is to reduce, or minimize, the damage, costs, and casualties resulting from an earthquake. A demonstration earthquake early warning system (ShakeAlert) is undergoing testing in the United States by the UC Berkeley Seismological Laboratory, Caltech, ETH Zurich, University of Washington, the USGS, and beta users in California and the Pacific Northwest. The UC Berkeley Seismological Laboratory has created a smartphone app called MyEEW, which interfaces with the ShakeAlert system to deliver early warnings to individual users. Many critical facilities (transportation, police, and fire) have control rooms, which could run a centralized interface, but our ShakeAlert Beta Testers have also expressed their need for mobile options. This app augments the basic ShakeAlert Java desktop applet by allowing workers off-site (or merely out of hearing range) to be informed of coming hazards. MyEEW receives information from the ShakeAlert system to provide users with real-time information about shaking that is about to happen at their individual location. It includes a map, timer, and earthquake information similar to the Java desktop User Display. The app will also feature educational material to help users craft their own response and resiliency strategies. The app will be open to UC Berkeley Earthquake Research Affiliates members for testing in the near future.

Innovation and dedication underpin management of sudden oak death (Phytophthora ramorum) in California and Oregon forests

Treesearch

Susan J. Frankel

2017-01-01

This special issue of Forest Phytophthoras serves as part of the proceedings from the Sixth Sudden Oak Death Science Symposium held June 21 -23, 2016 at Fort Mason Center in San Francisco, CA, USA. The symposium marked almost 16 years to the day that David Rizzo (UC Davis) and Matteo Garbelotto (UC Berkeley) identified the cause of sudden oak death to be a previously...

Mendelevium: The Way It Was

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

A reel of black & white film shot nearly 60 years ago has surfaced at Berkeley Lab, depicting the discovery of Mendelevium - or Element 101 - as reenacted by some of the legendary scientists who did the actual work at that time. Since the 1940s, Berkeley Lab scientists were locked in a race to synthesize new elements, and more often than not, they came out winners. Sixteen elements, most of them in the actinide series at the bottom of the periodic table, were discovered and synthesized by its researchers. Retired Berkeley Lab physicist Claude Lyneis found the reel inmore » a box of dusty and deteriorating films slated for disposal. Using digital editing skills he acquired to make videos of his son's lacrosse team, Lyneis has produced and narrated an excerpt of this nearly-lost footage. It is an entertaining and informative look at the pioneering physics performed at UC Berkeley and Lawrence Berkeley National Laboratory's hillside campus.« less

Mendelevium: The Way It Was

ScienceCinema

None

2018-05-30

A reel of black & white film shot nearly 60 years ago has surfaced at Berkeley Lab, depicting the discovery of Mendelevium - or Element 101 - as reenacted by some of the legendary scientists who did the actual work at that time. Since the 1940s, Berkeley Lab scientists were locked in a race to synthesize new elements, and more often than not, they came out winners. Sixteen elements, most of them in the actinide series at the bottom of the periodic table, were discovered and synthesized by its researchers. Retired Berkeley Lab physicist Claude Lyneis found the reel in a box of dusty and deteriorating films slated for disposal. Using digital editing skills he acquired to make videos of his son's lacrosse team, Lyneis has produced and narrated an excerpt of this nearly-lost footage. It is an entertaining and informative look at the pioneering physics performed at UC Berkeley and Lawrence Berkeley National Laboratory's hillside campus.

PART 1 OF 2 PART PANORAMA WITH NO. CA213 VIEW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PART 1 OF 2 PART PANORAMA WITH NO. CA-2-13 VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY WITH VIW AT REAR OF ALPHA SIGMA PHI HOUSE BY WILLIAM C. HAYS, 1920, AT 2739 CHANNING. SEEN FROM SE CORNER LOOKING WEST. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

Secrets of the Soil (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brodie, Eoin; Northen, Trent; Jansson, Janet

2011-11-07

Four Berkeley Lab scientists unveil the "Secrets of the Soil"at this Nov. 7, 2011 Science at the Theater event. Eoin Brodie, Janet Jansson, Margaret Torn and Trent Northen talk about their research and how soil could hold the key to our climate and energy future.The discussion was moderated by John Harte, who holds a joint professorship in the Energy and Resources Group and the Ecosystem Sciences Division of UC Berkeley's College of Natural Resources

Diversity, Equity, & Inclusion at Berkeley Lab

Science.gov Websites

; Latest News May 23 UC Webinar on Improving Mental Health Awareness African American ERG Hosts Emotional Intelligence Workshop Joe Palca to Interview Geri Richmond for June 11 'Women in Science' Talk Building

The World as a Hologram (LBNL Summer Lecture Series)

ScienceCinema

Bousso, Raphael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2017-12-09

Summer Lecture Series 2006: UC Berkeley's Raphael Bousso presents a friendly introduction to the ideas behind the holographic principle, which may be very important in the hunt for a theory of quantum gravity.

Development of a safety management protocol.

DOT National Transportation Integrated Search

2008-09-01

The UC Berkeley Traffic Safety Center (TSC) has produced this report under a contract from the California Department of Transportation : (Caltrans). The aim is to address workplace injuries and accidents among Caltrans employees and develop recommend...

Graduate Programs in Building Science at UC Berkeley

Science.gov Websites

aims to influence practice and improve the performance of buildings by educating future members of the influence design practice. Coursework is largely decided on an individual basis through consultation between

SETI@home

Science.gov Websites

experiment, based at UC Berkeley, that uses Internet-connected computers in the Search for Extraterrestrial several hours to be sure. If that didn't solve the problem, it probably means the index the server uses to

Wave Propagation Problems in Certain Elastic Anisotropic Half Spaces.

DTIC Science & Technology

1980-12-01

874-882. 33. Paul , S.L., and Robinson, A.R., "Interaction of Plane Elastic Waves with a Cylindrical Cavity," Technical Documentary Report Mo. RTD...Professor Paul M. Naghdi University of California Department of Mechanical Engineering Berkeley, California 94720 Professor A. J. Durelli Oakland...Burt Paul University of Pennsylvania Towne School of Civil and Mechanical Engineering Philadelphia, Pennsylvania 19104 Professor H. W. Liu Syracuse

Site Environmental Report for 2009, Volume I

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lackner, Regina

2010-08-17

Each year, the University of California (UC), as the managing and operating contractor of the Ernest Orlando Lawrence Berkeley National Laboratory, prepares an integrated report regarding its environmental programs to satisfy the requirements of United States Department of Energy (DOE) Order 231.1A, Environment, Safety, and Health Reporting.1 The Site Environmental Report for 2009 summarizes Berkeley Lab's environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year (CY) 2009. Throughout this report, 'Berkeley Lab' or 'LBNL' refers both to (1) the multiprogram scientific facility the UC manages and operates on the 202-acre university-owned site located in themore » hills above the UC Berkeley campus, and the site itself, and (2) the UC as managing and operating contractor for Ernest Orlando Lawrence Berkeley National Laboratory. The report is separated into two volumes. Volume I is organized into an executive summary followed by six chapters that contain an overview of LBNL, a discussion of its environmental management system (EMS), the status of environmental programs, summarized results from surveillance and monitoring activities, and quality assurance (QA) measures. Volume II contains individual data results from surveillance and monitoring activities. The Site Environmental Report is distributed by releasing it on the World Wide Web (Web) from the Berkeley Lab Environmental Services Group (ESG) home page, which is located at www.lbl.gov/ehs/esg/. Many of the documents cited in this report also are accessible from the ESG Web page. Links to documents available on the Web are given with the citations in the References section. CD and printed copies of this Site Environmental Report are available upon request. The report follows Berkeley Lab's policy of using the International System of Units (SI), also known as the metric system of measurements. Whenever possible, results are also reported using the more conventional (non-SI) system of measurements, because the non-SI system is referenced by several current regulatory standards and is more familiar to some readers. Two tables are provided at the end of the Glossary to help readers: Table G-1 defines the prefixes used with SI units of measurement, and Table G-2 provides conversions to non-SI units. Years mentioned in this report refer to calendar years unless specified as fiscal year(s). Berkeley Lab's fiscal year (FY) is October 1 to September 30, and begins in the year previous to its name, i.e., FY 2009 was from October 1, 2008, to September 30, 2009. For ease of reference, a key to acronyms and abbreviations used in this report can be found directly after the text, at the end of Chapter 6. Following that is also a glossary for readers who may be unfamiliar with some of the terms used in this report. This report was prepared under the direction of Ron Pauer of ESG. Please address any questions regarding this report to him by telephone at 510-486-7614, or by e-mail at ropauer@lbl.gov. The primary contributors were David Baskin, Tim Bauters, Ned Borglin, Robert Fox, John Jelinski, Ginny Lackner, Patrick Thorson, Linnea Wahl, and Suying Xu (Volume II). Readers are encouraged to comment on this report by completing the survey form found at the ESG Web page where this report is available.« less

Art in Science Promoting Interest in Research and Exploration (ASPIRE)

NASA Astrophysics Data System (ADS)

Fillingim, M.; Zevin, D.; Thrall, L.; Croft, S.; Raftery, C.; Shackelford, R.

2015-11-01

Led by U.C. Berkeley's Center for Science Education at the Space Sciences Laboratory in partnership with U.C. Berkeley Astronomy, the Lawrence Hall of Science, and the YMCA of the Central Bay Area, Art in Science Promoting Interest in Research and Exploration (ASPIRE) is a NASA EPOESS-funded program mainly for high school students that explores NASA science through art and highlights the need for and uses of art and visualizations in science. ASPIRE's aim is to motivate more diverse young people (especially African Americans) to learn about Science, Technology, Engineering, and Mathematics (STEM) topics and careers, via 1) Intensive summer workshops; 2) Drop-in after school workshops; 3) Astronomy visualization-focused outreach programming at public venues including a series of free star parties where the students help run the events; and 5) A website and a number of social networking strategies that highlight our youth's artwork.

A New Direction in Psychology and Politics

ERIC Educational Resources Information Center

Goldstein, Evan R.

2008-01-01

Jonathan Haidt remembers reading "Metaphors We Live By", the influential book that George P. Lakoff, a professor of linguistics and cognitive science at the University of California at Berkeley, wrote with Mark L. Johnson, a professor of philosophy at the University of Oregon. The book drew on cognitive science, psychology, linguistics, and…

Physics 101: What Our Next President Needs to Know (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muller, Rich

2008-10-13

Rich Muller, author of Physics for Future Presidents, argues that the next president can't afford to be ignorant about the science behind terrorism, nuclear dangers, energy, space, and global warming. Muller, a MacArthur Fellow, Berkeley Lab physicist, and one of the most popular lecturers at UC Berkeley, discusses what it takes to survive in today's increasingly dangerous world -- information essential to the next commander-in-chief. He presented his talk Oct. 13, 2008.

Beyond The Human Genome: What's Next? (LBNL Summer Lecture Series)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rokhsar, Daniel

2003-06-18

UC Berkeley's Daniel Rokhsar and his colleagues were instrumental in contributing the sequences for three of the human body's chromosomes in the effort to decipher the blueprint of life- the completion of the DNA sequencing of the human genome. Now he is turning to the structure and function of genes in other organisms, some of them no less important to the planet's future than the human map. Hear the latest in this lecture from Lawrence Berkeley National Laboratory.

Beyond The Human Genome: What's Next? (LBNL Summer Lecture Series)

ScienceCinema

Rokhsar, Daniel

2018-04-27

UC Berkeley's Daniel Rokhsar and his colleagues were instrumental in contributing the sequences for three of the human body's chromosomes in the effort to decipher the blueprint of life- the completion of the DNA sequencing of the human genome. Now he is turning to the structure and function of genes in other organisms, some of them no less important to the planet's future than the human map. Hear the latest in this lecture from Lawrence Berkeley National Laboratory.

Physics 101: What Our Next President Needs to Know (LBNL Science at the Theater)

ScienceCinema

Muller, Rich

2018-06-12

Rich Muller, author of Physics for Future Presidents, argues that the next president can't afford to be ignorant about the science behind terrorism, nuclear dangers, energy, space, and global warming. Muller, a MacArthur Fellow, Berkeley Lab physicist, and one of the most popular lecturers at UC Berkeley, discusses what it takes to survive in today's increasingly dangerous world -- information essential to the next commander-in-chief. He presented his talk Oct. 13, 2008.

A community of scientists: cultivating scientific identity among undergraduates within the Berkeley Compass Project

NASA Astrophysics Data System (ADS)

Aceves, Ana V.; Berkeley Compass Project

2015-01-01

The Berkeley Compass Project is a self-formed group of graduate and undergraduate students in the physical sciences at UC Berkeley. Our goals are to improve undergraduate physics education, provide opportunities for professional development, and increase retention of students from populations typically underrepresented in the physical sciences. For students who enter as freshmen, the core Compass experience consists of a summer program and several seminar courses. These programs are designed to foster a diverse, collaborative student community in which students engage in authentic research practices and regular self-reflection. Compass encourages undergraduates to develop an identity as a scientist from the beginning of their university experience.

One of Sociology's Most Influential Scholars

ERIC Educational Resources Information Center

Chronicle of Higher Education, 2006

2006-01-01

Robert N. Bellah turns 80 early next year, and Duke University Press is honoring him with "The Robert Bellah Reader," edited by Bellah, an emeritus professor of sociology at the University of California at Berkeley, and Steven M. Tipton, a professor of sociology at Emory University. The book, just published, presents a selection of…

Reduced Chemical Kinetic Mechanisms for Hydrocarbon Fuels

DTIC Science & Technology

2006-01-01

Technologies Reaction Engineering International 77 West 200 South, Suite # 210 Salt Lake City, UT 84101 3Professor Department of Mechanical ... Engineering University of California, Berkeley Berkeley, CA 94720 4Program Leader for Computational Chemistry Lawrence Livermore National Laboratory...species by the error introduced by assuming they are in quasi-steady state. The reduced mechanisms have been compared to detailed chemistry calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, Iain; Regnier, Cindy

Science at the Theater: Berkeley Lab scientists reveal the latest research on how to reduce your carbon footprint at home, work, and when you shop. Learn how even small choices can have a big impact. Iain Walker's research focuses on optimizing the energy use and comfort of buildings. He's a staff scientist in the Energy Performance of Buildings Group, which is part of Berkeley Lab's Environmen...tal Energy Technologies Division. He's also executive editor of Home Energy Magazine. Cindy Regnier is a Project Manager in the Environmental Energy Technologies Division at Berkeley Lab. She has over 13 years of mechanical engineeringmore » design experience, with a focus on low-energy buildings. Her projects have included several LEED Platinum buildings and the design of a 200,000 sf carbon neutral, net-zero energy science museum in San Francisco. Eric Masanet is Acting Deputy Leader of the International Energy Studies Group at Berkeley Lab. His research focuses on life-cycle assessments and energy efficiency analysis. He holds a joint research appointment in the Institute of Transportation Studies at UC Berkeley.« less

CfAO Fall Science Retreat 2017

Science.gov Websites

: Mark Chun, Astronomy Dept., U. Hawaii) Point Spread Function Reconstruction for AO Science (Organizer : Jessica Lu, Astronomy Dept., UC Berkeley) High Contrast Exoplanet Instrumentation Program for TMT (Organizer: Michael Fitzgerald, Astronomy Dept., UCLA) Special Plenary Session: TMT international training

Homepage P. Fischer, LBNL, Berkeley CA | UC Santa Cruz CA

Science.gov Websites

mesoscale magnetic x-ray microscopy and spectroscopy (ultra-)fast spin dynamics soft x-ray tomography of condensed matter x-ray optics publications presentations invited talks conference contributions curriculum

A. Paul Alivisatos

Science.gov Websites

Chancellor for Research Professor & Samsung Distinguished Chair in Nanoscience and Nanotechnology Research Department of Chemistry and Materials Science and Engineering University of California, Berkeley

A community of educators: professional development for graduate students within the Berkeley Compass Project

NASA Astrophysics Data System (ADS)

Schwab, Josiah; Roth, Nathaniel; Berkeley Compass Project

2015-01-01

The Berkeley Compass Project is a self-formed group of graduate and undergraduate students in the physical sciences at UC Berkeley. Our goals are to improve undergraduate physics education, provide opportunities for professional development, and increase retention of students from populations typically underrepresented in the physical sciences. Graduate students, together with upper-level undergraduates, design and run all Compass programs. We strive to create a community of educators that incorporates best practices from the science education literature. Along the way, we develop experience in curriculum development, fundraising, grant writing, interfacing with university administration, and other aspects of running an effective organization. Our experience in Compass leaves us better poised to be successful researchers, teachers, and mentors.

NASA Opportunities in Visualization, Art, and Science (NOVAS)

NASA Astrophysics Data System (ADS)

Fillingim, M. O.; Zevin, D.; Croft, S.; Thrall, L.; Raftery, C. L.; Shackelford, R. L., III

2014-12-01

Led by members of UC Berkeley's Multiverse education team at the Space Sciences Laboratory (http://multiverse.ssl.berkeley.edu/), in partnership with UC Berkeley Astronomy, NASA Opportunities in Visualization, Art and Science (NOVAS) is a NASA-funded program mainly for high school students that explores NASA science through art and highlights the need for and uses of art and visualizations in science. The project's aim is to motivate more diverse young people (especially African Americans) to consider Science, Technology, Engineering, and Mathematics (STEM) careers. The program offers intensive summer workshops at community youth centers, afterschool workshops at a local high school, a year-round internship for those who have taken part in one or more of our workshops, public and school outreach, and educator professional development workshops. By adding art (and multimedia) to STEM learning, we wanted to try a unique "STEAM" approach, highlighting how scientists and artists often collaborate, and why scientists need visualization experts. The program values the rise of the STEAM teaching concept, particularly that art and multimedia projects can help communicate science concepts more effectively. We also promote the fact that art and visualization skills can lead to jobs and broader participation in science, and we frequently work with and showcase scientific illustrators and other science visualization professionals.

A brief history of the Bioengineering Institute of California and the UC System-wide Symposia.

PubMed

Chien, Shu

2011-04-01

The plan to establish a Multicampus Research Unit (MRU) on Bioengineering in the University of California (UC) System started in August 1999. The cooperative efforts of the UC campuses led to the formal establishment of the Bioengineering Institute of California (BIC) in October 2003. Three years prior to the BIC establishment, the System-wide Annual Bioengineering Symposium was started at UC Davis. The Symposia were then hosted sequentially by UC Santa Barbara, UC Berkeley, UCSD, UC Santa Cruz, UC Irvine, UCSF, UCLA, and UC Riverside, with the completion of the first cycle of a decade in the newest campus of UC Merced in 2009. The second cycle began in 2010 with the Symposium returning again to UC Davis. Each campus hosted a wonderful Symposium, with the active participation of students and faculty from all campuses, with the motto of "Ten campuses united as one, learning and growing together." These Symposia have contributed significantly to the collaborative research and training of students and young scientists in bioengineering, as well as fruitful interactions with industry and government agencies, which have provided strong support for these valuable meetings. The BIC will endeavor to further enhance these efforts by fostering research collaborations and joint education and training activities, with the ultimate goal of advancing bioengineering for the improvement of human health and wellbeing.

Perceived Managerial and Leadership Effectiveness within Mexican and British Public Sector Hospitals: A Cross-Nation Comparative Analysis

ERIC Educational Resources Information Center

Hamlin, Robert G.; Ruiz, Carlos E.; Wang, Jia

2011-01-01

Stephen M. Shortell, dean of the School of Public Health, distinguished professor of health policy and management, and professor of organization behavior in the Haas School of Business, University of California-Berkeley, has argued that evidence-based management needs to be married with evidence-based medicine if sustainable improvement in the…

Two Billion Cars: What it Means for Climate and Energy Policy

ScienceCinema

Daniel Sperling

2017-12-09

April 13, 2009: Daniel Sperling, director of the Institute of Transportation Studies at UC Davis, presents the next installment of Berkeley Lab's Environmental Energy Technologies Divisions Distinguished Lecture series. He discusses Two Billion Cars and What it Means for Climate and Energy Policy.

Two Billion Cars: What it Means for Climate and Energy Policy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel Sperling

2009-04-15

April 13, 2009: Daniel Sperling, director of the Institute of Transportation Studies at UC Davis, presents the next installment of Berkeley Lab's Environmental Energy Technologies Divisions Distinguished Lecture series. He discusses Two Billion Cars and What it Means for Climate and Energy Policy.

A Community of Scientists and Educators: The Compass Project at UC Berkeley

NASA Astrophysics Data System (ADS)

Roth, Nathaniel; Schwab, Josiah

2016-01-01

The Berkeley Compass Project is a self-formed group of graduate and undergraduate students in the physical sciences at the University of California, Berkeley. Its goals are to improve undergraduate physics education, provide opportunities for professional development, and increase retention of students from populations underrepresented in the physical sciences. For undergraduate students, the core Compass experience consists of a summer program and several seminar courses. These programs are designed to foster a diverse, collaborative student community in which students engage in authentic research practices and regular self-reflection. Graduate students, together with upper-level undergraduates, design and run all Compass programs. Compass strives to incorporate best practices from the science education literature. Experiences in Compass leave participants poised to be successful students researchers, teachers, and mentors.

Putting Carbon in its Place: What You Can Do (LBNL Science at the Theater)

ScienceCinema

Walker, Iain; Regnier, Cindy [LBNL, Environmental Energy Technologies Division; Miller, Jeff; Masanet, Eric

2018-06-28

Science at the Theater: Berkeley Lab scientists reveal the latest research on how to reduce your carbon footprint at home, work, and when you shop. Learn how even small choices can have a big impact. Iain Walker's research focuses on optimizing the energy use and comfort of buildings. He's a staff scientist in the Energy Performance of Buildings Group, which is part of Berkeley Lab's Environmen...tal Energy Technologies Division. He's also executive editor of Home Energy Magazine. Cindy Regnier is a Project Manager in the Environmental Energy Technologies Division at Berkeley Lab. She has over 13 years of mechanical engineering design experience, with a focus on low-energy buildings. Her projects have included several LEED Platinum buildings and the design of a 200,000 sf carbon neutral, net-zero energy science museum in San Francisco. Eric Masanet is Acting Deputy Leader of the International Energy Studies Group at Berkeley Lab. His research focuses on life-cycle assessments and energy efficiency analysis. He holds a joint research appointment in the Institute of Transportation Studies at UC Berkeley.

Seeing the Light (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brunger, Axel; Segalman, Rachel; Westphal, Andrew

2011-09-12

Berkeley Lab's Science at the Theater event "Seeing the Light" took place on Sept 12, 2011, at Berkeley Repertory's Roda Theatre. Learn how the Advanced Light Source is improving medicine, paving the way for clean energy, changing the future of computers, and much more. Featured speakers are Berkeley Lab's Roger Falcone, Rachel Segalman, Andrew Westphal, and Stanford University's Axel Brunger. Rachel Segalman: The future of clean energy technology relies on a better understanding of materials at the nanoscale. Berkeley Lab's Rachel Segalman uses the ALS to conduct this research, which could lead to improved photovoltaics and fuel cells. Axel Brunger:more » Improved treatment for human diseases hinges on understanding molecular-scale processes. Stanford University's Axel Brunger will discuss a new melanoma drug that was developed by a local company, Plexxikon, using the ALS for X-ray data collection. Andrew Westphal: What's comet dust made of? Andrew Westphal of UC Berkeley's Space Sciences Laboratory uses the ALS to study comet dust and interplanetary space dust collected by a NASA spacecraft. Moderated by Roger Falcone, Division Director of the Advanced Light Source« less

Editorial: Special issue dedicated to Gabor Somorjai's 80th birthday

NASA Astrophysics Data System (ADS)

2016-06-01

This special issue of Surface Science has been prepared to honor Professor Gabor A. Somorjai on the occasion of his 80th birthday. Professor Somorjai was born on May 4, 1935 in Budapest, Hungary. In 1953 he enrolled as a chemical engineering student at the Technical University of Budapest. Gabor was an active participant in the Hungarian Revolution of 1956. When the Soviet military crushed the revolution, he had to leave the country by walking across the border with his sister and his future wife. After immigrating to the USA in 1957, he applied to begin graduate studies and was accepted at the University of California, Berkeley. Gabor received a PhD in Chemistry in 1960, only three years later. Following a short sojourn at IBM, he returned to Berkeley in 1964 to take up a faculty position in the Department of Chemistry and the Lawrence Berkeley National Laboratory, which he still holds today. For the interested reader, more can be learned about Gabor's fascinating life in his autobiography, ;An American Scientist: The Autobiography of Gabor A. Somorjai.

Electronic resistance tomography imaging of spatial moisture distribution, moisture distribution and movement in pavements

DOT National Transportation Integrated Search

1997-07-01

Electronic resistance tomography (ERT) was used to follow the infiltration of water into a pavement section at the UC Berkeley Richmond Field Station. A volume of pavement 1 m square and 1.29 m in depth was sampled by an ERT array consisting of elect...

Im Gesprach: An Interview with Claire Kramsch on the "Multilingual Subject"

ERIC Educational Resources Information Center

Kramsch, Claire; Gerhards, Sascha

2012-01-01

In her recently published book "The Multilingual Subject: What foreign language learners say about their experience and why it matters", UC Berkeley applied-linguist Claire Kramsch approaches language learning from a new, visionary perspective. Foregrounding the interplay of cultural aspects in language learning, Kramsch understands…

Final Report for DOE Grant DE-FG02-03ER25579; Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puckett, Elbridge Gerry; Miller, Gregory Hale

Much of the work conducted under the auspices of DE-FG02-03ER25579 was characterized by an exceptionally close collaboration with researchers at the Lawrence Berkeley National Laboratory (LBNL). For example, Andy Nonaka, one of Professor Miller's graduate students in the Department of Applied Science at U. C. Davis (UCD) wrote his PhD thesis in an area of interest to researchers in the Applied Numerical Algorithms Group (ANAG), which is a part of the National Energy Research Supercomputer Center (NERSC) at LBNL. Dr. Nonaka collaborated closely with these researchers and subsequently published the results of this collaboration jointly with them, one article inmore » a peer reviewed journal article and one paper in the proceedings of a conference. Dr. Nonaka is now a research scientist in the Center for Computational Sciences and Engineering (CCSE), which is also part of the National Energy Research Supercomputer Center (NERSC) at LBNL. This collaboration with researchers at LBNL also included having one of Professor Puckett's graduate students in the Graduate Group in Applied Mathematics (GGAM) at UCD, Sarah Williams, spend the summer working with Dr. Ann Almgren, who is a staff scientist in CCSE. As a result of this visit Sarah decided work on a problem suggested by the head of CCSE, Dr. John Bell, for her PhD thesis. Having finished all of the coursework and examinations required for a PhD, Sarah stayed at LBNL to work on her thesis under the guidance of Dr. Bell. Sarah finished her PhD thesis in June of 2007. Writing a PhD thesis while working at one of the University of California (UC) managed DOE laboratories is long established tradition at UC and Professor Puckett has always encouraged his students to consider doing this. Another one of Professor Puckett's graduate students in the GGAM at UCD, Christopher Algieri, was partially supported with funds from DE-FG02-03ER25579 while he wrote his MS thesis in which he analyzed and extended work originally published by Dr. Phillip Colella, the head of ANAG, and some of his colleagues. Chris Algieri is now employed as a staff member in Dr. Bill Collins' Climate Science Department in the Earth Sciences Division at LBNL working with computational models of climate change. Finally, it should be noted that the work conducted by Professor Puckett and his students Sarah Williams and Chris Algieri and described in this final report for DOE grant # DE-FC02-03ER25579 is closely related to work performed by Professor Puckett and his students under the auspices of Professor Puckett's DOE SciDAC grant DE-FC02-01ER25473 An Algorithmic and Software Framework for Applied Partial Differential Equations: A DOE SciDAC Integrated Software Infrastructure Center (ISIC). Dr. Colella was the lead PI for this SciDAC grant, which was comprised of several research groups from DOE national laboratories and five university PI's from five different universities. In theory Professor Puckett tried to use funds from the SciDAC grant to support work directly involved in implementing algorithms developed by members of his research group at UCD as software that might be of use to Puckett's SciDAC CoPIs. (For example, see the work reported in Section 2.2.2 of this final report.) However, since there is considerable lead time spent developing such algorithms before they are ready to become `software' and research plans and goals change as the research progresses, Professor Puckett supported each member of his research group partially with funds from the SciDAC APDEC ISIC DE-FC02-01ER25473 and partially with funds from this DOE MICS grant DE-FC02-03ER25579. This has necessarily resulted in a significant overlap of project areas that were funded by both grants. In particular, both Sarah Williams and Chris Algieri were supported partially with funds from grant # DE-FG02-03ER25579, for which this is the final report, and in part with funds from Professor Puckett's DOE SciDAC grant # DE-FC02-01ER25473. For example, Sarah Williams received support from DE-FC02- 01ER25473 and DE-FC02-03ER25579, both while at UCD taking classes and writing her MS thesis and during the first year she was living in Berkeley and working at LBNL on her PhD thesis. In Chris Algieri's case he was at UCD during the entire time he received support from both grants. More specific details of their work are included in the report.« less

Comprehensive facilities plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-09-01

The Ernest Orlando Lawrence Berkeley National Laboratory`s Comprehensive Facilities Plan (CFP) document provides analysis and policy guidance for the effective use and orderly future development of land and capital assets at the Berkeley Lab site. The CFP directly supports Berkeley Lab`s role as a multiprogram national laboratory operated by the University of California (UC) for the Department of Energy (DOE). The CFP is revised annually on Berkeley Lab`s Facilities Planning Website. Major revisions are consistent with DOE policy and review guidance. Facilities planing is motivated by the need to develop facilities for DOE programmatic needs; to maintain, replace and rehabilitatemore » existing obsolete facilities; to identify sites for anticipated programmatic growth; and to establish a planning framework in recognition of site amenities and the surrounding community. The CFP presents a concise expression of the policy for the future physical development of the Laboratory, based upon anticipated operational needs of research programs and the environmental setting. It is a product of the ongoing planning processes and is a dynamic information source.« less

Paul G. Silver (1948-2009)

NASA Astrophysics Data System (ADS)

Solomon, Sean C.

2009-11-01

A pioneer in the novel application of seismic observations to infer the flow field of Earth's mantle and the mechanics of fault zones, Paul Gordon Silver tragically was killed on 7 August in an automobile accident that also took the life of his 22-year-old daughter, Celine. Born and raised in Los Angeles, Calif., Paul received all of his degrees from the University of California. Following receipt of a B.A. in psychology from the University of California (UC), Los Angeles (1970), he pursued a career as a musician for several years. Drawn to Earth science, Paul obtained a B.A. in geology from UC Berkeley, in 1976, and he was recruited by Tom Jordan (now at the University of Southern California) to the graduate program of the Scripps Institution of Oceanography at UC San Diego.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garabedian, G.

This document details the decontamination and decommissioning (D&D) process of Rooms 248 and 250 of Building 62 at the Ernest Orlando Lawrence Berkeley National Laboratory (LBNL). The document describes the D&D efforts for the rooms, their contents, and adjacent areas containing ancillary equipment. The rooms and equipment, before being released, were required to meet the unrestricted release criteria and requirements set forth in DOE orders 5400.5 and 5480.11, LBNL`s internal release-criteria procedure (EH&S Procedure 708), and the LBNL Radiological Control Manual. The radioactive material and items not meeting the release criteria were either sent to the Hazardous Waste Handling Facilitymore » (HWHF) for disposal or transferred to other locations approved for radioactive material. The D&D was undertaken by the Radiation Protection Group of LBNL`s Environment, Health and Safety (EH&S) Division at the request of the Materials Sciences Division. Current and past use of radioactive material in both Rooms 248 and 250 necessitated the D&D in order to release both rooms for nonradioactive work. (1) Room 248 was designated a {open_quotes}controlled area.{close_quotes} There was contained radioactive material in some of the equipment. The previous occupants of Room 248 had worked with radioactive materials. (2) Room 250 was designated a {open_quotes}Radioactive Materials Management Area{close_quotes} (RMMA) because the current occupants used potentially dispersible radioisotopes. Both laboratories, during the occupancy of U.C. Berkeley Professor Leo Brewer and Ms. Karen Krushwitz, were kept in excellent condition. There was a detailed inventory of all radioactive materials and chemicals. All work and self surveys were documented. The labs were kept extremely orderly, clean, and in compliance. In October 1993 Ms. Krushwitz received an award in recognition of her efforts in Environmental Protection, Health, and Safety at LBNL.« less

Multi-sensor radiation detection, imaging, and fusion

NASA Astrophysics Data System (ADS)

Vetter, Kai

2016-01-01

Glenn Knoll was one of the leaders in the field of radiation detection and measurements and shaped this field through his outstanding scientific and technical contributions, as a teacher, his personality, and his textbook. His Radiation Detection and Measurement book guided me in my studies and is now the textbook in my classes in the Department of Nuclear Engineering at UC Berkeley. In the spirit of Glenn, I will provide an overview of our activities at the Berkeley Applied Nuclear Physics program reflecting some of the breadth of radiation detection technologies and their applications ranging from fundamental studies in physics to biomedical imaging and to nuclear security. I will conclude with a discussion of our Berkeley Radwatch and Resilient Communities activities as a result of the events at the Dai-ichi nuclear power plant in Fukushima, Japan more than 4 years ago.

B.Gregory Lecture

ScienceCinema

None

2018-05-18

Third series of "Gregory lectures" on the memory of B. Gregory (1919-1977), DG from 1965 to 1970. The first conference B. Gregory is presented by Professor V. Weisskopf, his predecessor. Chriss Greeg from Berkeley also speaks.

Visiting Scholars Program in Building Science at UC Berkeley

Science.gov Websites

part of the evaluation process, as it is essential that there is a relationship between your interests and the research being conducted at CBE. Visiting scholars must have some prior research experience with information on education, research experience, papers published and technical skills (e.g

Freshmen Entering the University of California, Fall 1966.

ERIC Educational Resources Information Center

Mock, Kathleen

The report interprets data collected by the American Council on Education on freshmen at 7 University of California (UC) campuses during a fall 1966 survey of 251 colleges and universities. The 7 campuses are Davis, Berkeley, Irvine, Los Angeles, Riverside, Santa Barbara, and Santa Cruz. Students responded to questions about their backgrounds,…

Taking Off the Cape: The Stories of Novice Urban Leadership

ERIC Educational Resources Information Center

Tredway, Lynda; Brill, Fred; Hernandez, Janette

2007-01-01

New administrators in urban schools face enormous challenges. The novice leaders in this study are graduates of a preparation program at UC Berkeley, and are participants in a leadership induction program. This research examines one aspect of their new position--disciplinarian--through the lens of leadership stories. Although the middle manager…

University as Publisher: Summary of a Meeting Held at UC Berkeley on November 1, 2007

ERIC Educational Resources Information Center

Harley, Diane, Ed.

2008-01-01

With the advent of electronic publishing, the scholarly communication landscape at universities has become increasingly diverse. Multiple stakeholders including university presses, libraries, and central IT departments are challenged by the increasing volume and the rapidity of production of these new forms of publication in an environment of…

CALINVASIVES: a revolutionary tool to monitor invasive threats

Treesearch

M. Garbelotto; S. Drill; C. Powell; J. Malpas

2017-01-01

CALinvasives is a web-based relational database and content management system (CMS) cataloging the statewide distribution of invasive pathogens and pests and the plant hosts they impact. The database has been developed as a collaboration between the Forest Pathology and Mycology Laboratory at UC Berkeley and Calflora. CALinvasives will combine information on the...

Linda S. Gottfredson

ERIC Educational Resources Information Center

Wainer, Howard; Robinson, Daniel H.

2009-01-01

This article presents an interview with Linda Gottfredson (nee Howarth), who obtained her BA (psychology, Phi Beta Kappa) from UC Berkeley in 1969, served in the Peace Corps in the Malaysian Health Service from 1969 to 1972, and received her PhD (sociology) from Johns Hopkins University (JHU) in 1976. She was Research Scientist at JHU's Center for…

Advancing Space Sciences through Undergraduate Research Experiences at UC Berkeley's Space Sciences Laboratory - a novel approach to undergraduate internships for first generation community college students

NASA Astrophysics Data System (ADS)

Raftery, C. L.; Davis, H. B.; Peticolas, L. M.; Paglierani, R.

2015-12-01

The Space Sciences Laboratory at UC Berkeley launched an NSF-funded Research Experience for Undergraduates (REU) program in the summer of 2015. The "Advancing Space Sciences through Undergraduate Research Experiences" (ASSURE) program recruited heavily from local community colleges and universities, and provided a multi-tiered mentorship program for students in the fields of space science and engineering. The program was focussed on providing a supportive environment for 2nd and 3rd year undergraduates, many of whom were first generation and underrepresented students. This model provides three levels of mentorship support for the participating interns: 1) the primary research advisor provides academic and professional support. 2) The program coordinator, who meets with the interns multiple times per week, provides personal support and helps the interns to assimilate into the highly competitive environment of the research laboratory. 3) Returning undergraduate interns provided peer support and guidance to the new cohort of students. The impacts of this program on the first generation students and the research mentors, as well as the lessons learned will be discussed.

Hubble Finds Supernova Companion Star after Two Decades of Searching

NASA Image and Video Library

2017-12-08

This is an artist's impression of supernova 1993J, an exploding star in the galaxy M81 whose light reached us 21 years ago. The supernova originated in a double-star system where one member was a massive star that exploded after siphoning most of its hydrogen envelope to its companion star. After two decades, astronomers have at last identified the blue helium-burning companion star, seen at the center of the expanding nebula of debris from the supernova. The Hubble Space Telescope identified the ultraviolet glow of the surviving companion embedded in the fading glow of the supernova. More info: Using NASA’s Hubble Space Telescope, astronomers have discovered a companion star to a rare type of supernova. The discovery confirms a long-held theory that the supernova, dubbed SN 1993J, occurred inside what is called a binary system, where two interacting stars caused a cosmic explosion. "This is like a crime scene, and we finally identified the robber," said Alex Filippenko, professor of astronomy at University of California (UC) at Berkeley. "The companion star stole a bunch of hydrogen before the primary star exploded." SN 1993J is an example of a Type IIb supernova, unusual stellar explosions that contains much less hydrogen than found in a typical supernova. Astronomers believe the companion star took most of the hydrogen surrounding the exploding main star and continued to burn as a super-hot helium star. “A binary system is likely required to lose the majority of the primary star’s hydrogen envelope prior to the explosion. The problem is that, to date, direct observations of the predicted binary companion star have been difficult to obtain since it is so faint relative to the supernova itself,” said lead researcher Ori Fox of UC Berkeley. Read more: 1.usa.gov/1Az5Qb9 Credit: NASA, ESA, G. Bacon (STScI) NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Obituary: Sumner P. Davis (1924-2008)

NASA Astrophysics Data System (ADS)

Feinberg, Jack

2011-12-01

University of California, Berkeley physicist Sumner P. Davis, a beloved teacher whose research centered on the optical spectroscopy of diatomic molecules found in the sun and other stars, died Dec. 31, 2008 in El Cerrito, CA after a brief illness. He was 84. After his military service during WWII, Davis finished his undergraduate work at UCLA in 1947, pursuing spectroscopy under the guidance of Joseph Ellis. Davis trained as a graduate student under molecular spectroscopist Francis Jenkins at UC Berkeley, where Davis used his ham radio expertise to construct an RF discharge to excite isotopes of diatomic selenium for his thesis. After receiving his Ph.D. from UC Berkeley, Davis went to MIT to postdoc under George Harrison, the premier artisan of finely-ruled diffraction gratings. In 1959, Jenkins invited Davis back to UC Berkeley to join the physics faculty, and Davis brought with him a highly prized gift - a diffraction grating presented to him by Harrison which Davis used for years to measure molecular spectra. At UC Berkeley Davis constructed a walk-in 15-foot-long spectrometer to produce detailed spectra of diatomic molecules of interest to astrophysics. With John G. Phillips he measured with high-precision the molecular constants of CN, C2, FeH, CS, SH and SiC2, TiO and others. Davis also studied the effect of the nuclear structure of Hg and Se on their optical spectra. He authored a book, Diffraction Grating Spectographs (1970), as well as monographs on CN and C2 spectra. Davis frequently traveled to the National Solar Observatory at Kitt Peak, to collect laboratory data using their Fourier transform spectrometer. He coauthored the book Fourier Transform Spectrometry (2001) with Mark C. Abrams and James Brault. In 1989, while returning to California after a long session on the spectrometer, his car, driven by Grace, his wife of 42 years, went off the road. Grace was killed but Sumner survived. Sumner Davis was, first and foremost, a consummate teacher: articulate and insightful, patient and empathetic. Joe Reader, a former student of Davis and now a director of the Atomic Spectroscopy Data Center at NIST in Gaithersburg, Maryland recalls: "Sumner always had an extremely positive attitude. When I told him that a vacuum pump I had built had exploded in the laboratory, he replied: "Well, now, we have to ask ourselves, what can we learn from this explosion?" Restless after his retirement in 1993, Davis returned to UC Berkeley for another decade to direct the upper division physics teaching laboratory. He created dozens of videos explaining the various laboratory experiments, ranging from Zeeman spectroscopy to Josephson junctions. Davis supervised 36 Ph.D.s during his career, many of whom became his lifelong friends. He would take his students bicycling through the Berkeley hills, and invite them to his home each Sunday evening to play music with other amateur musicians, with Davis playing (fairly respectable) oboe. Davis learned to fly as a young man while in the Army Air Corps, and he remained an avid glider pilot into his 80s. As recently as 2000, Davis served as president of the Pacific Soaring Council, Inc. He always offered his graduate students a ride in his glider, and Davis and his glider were pictured in National Geographic magazine after achieving an altitude record of 10,000+ feet over Arizona. He was a fellow of the American Physical Society and the Optical Society of America, and a member of the American Astronomical Society and the American Association of Physics Teachers. Upon his retirement, he received the Berkeley Citation. He was a NATO Senior Fellow in Science in 1967 and twice a visiting astronomer at the National Solar Observatory in Kitt Peak. Davis is survived by his wife, Robin Free, of El Cerrito, CA, who remarked, "He was like a 10-year-old boy. Every morning he would wake up and think, what adventures am I going to have today?" His recent e-mail sums up his spirit: "My desktop has been down for a week, and I am snowed with e-mail and behind on a few other things. Otherwise, all is well. We had 11 Chinese educators visit us, to look over all the labs. As I started to introduce our advanced lab, I put on my academic gown and a large conical wizard's cap, and told them how wizardry is necessary even in scientific Physics laboratories. I then made a pass through the lab rooms in my tie-dyed lab coat and the cat's hat from Dr. Seuss's Cat in the Hat. Got a few high fives from the students. The hat is now resting on the head of large giraffe in my office."

NASA Opportunities in Visualization, Art, and Science (NOVAS)

NASA Astrophysics Data System (ADS)

Fillingim, M. O.; Zevin, D.; Croft, S.; Thrall, L.; Shackelford, R. L., III

2015-12-01

Led by members of UC Berkeley's Multiverse education team at the Space Sciences Laboratory (http://multiverse.ssl.berkeley.edu/), in partnership with UC Berkeley Astronomy, NASA Opportunities in Visualization, Art and Science (NOVAS) is a NASA-funded program mainly for high school students that explores NASA science through art and highlights the need for and uses of art and visualizations in science. The project's aim is to motivate more diverse young people (especially African Americans) to consider Science, Technology, Engineering, and Mathematics (STEM) careers. The program offers intensive summer workshops at community youth centers, afterschool workshops at a local high school, a year-round internship for those who have taken part in one or more of our workshops, public and school outreach, and educator professional development workshops. By adding Art (fine art, graphic art, multimedia, design, and "maker/tinkering" approaches) to STEM learning, we wanted to try a unique combination of what's often now called the "STEAM movement" in STEM education. We've paid particular attention to highlighting how scientists and artists/tinkerers often collaborate, and why scientists need visualization and design experts. The program values the rise of the STEAM teaching concept, particularly that art, multimedia, design, and maker projects can help communicate science concepts more effectively. We also promote the fact that art, design, and visualization skills can lead to jobs and broader participation in science, and we frequently work with and showcase scientific illustrators and other science visualization professionals. This presentation will highlight the significant findings from our multi-year program.

Success of First-Generation College Students in a Selective Doctor of Optometry Program

ERIC Educational Resources Information Center

Joyce, Sharon T.

2017-01-01

What happens when former first-generation college (FGC) students successfully graduate from college and then aim for post-undergraduate education? The purpose of this dissertation is to compare differences between FGC students and non-FGC admissions profiles regarding end-of-first-year performance at UC Berkeley's School of Optometry. The aims of…

Technology Licensing for the Benefit of the Developing World: UC Berkeley's Socially Responsible Licensing Program

ERIC Educational Resources Information Center

Mimura, Carol

2007-01-01

In the years since the passage of the Bayh-Dole Act of 1980, university technology transfer success has been measured primarily by traditional metrics such as numbers of patents filed, revenue obtained from licensed patents and numbers of start-up companies founded to commercialize university intellectual property. Intellectual property (IP)…

An interview with Bruce A. Bolt

USGS Publications Warehouse

Spall, H.

1987-01-01

Professor Bruce Bolt was educated in Australia and first came to the United States in 1960 on a Fulbright Fellowship to the Lamont Geological Observatory of Columbia University. In 1963 he was appointed Director of the Seismographic Stations at the University of California at Berkeley. In June 1988, he steps down as Director but his association will continue as Professor of Seismology. Henry Spall interviewed him again 10 years after a 977 interview published in the Earthquake Information Bulletin. 

Sunrayce 97 Continues Day 2 - Terre Haute to Godfrey

Science.gov Websites

overall lead as Sunrayce 97 completed its second day of running. Their elapsed time for the day was 4:10 :31. Second place went to Massachusetts Institute of Technology, 4:11:27. The two teams are neck-in University-Los Angeles, 4:23:01. The daily Sportsmanship award went to Stanford University/UC - Berkeley for

Successful Demonstration of New Isolated Bridge System at UCB Shaking Table

Science.gov Websites

other events Successful Demonstration of New Isolated Bridge System at UCB Shaking Table PEER Events Successful Demonstration of New Isolated Bridge System at UCB Shaking Table On May 26, 2010 over 100 demonstration of a new isolated bridge system at the PEER Earthquake Simulator Laboratory at UC Berkeley’s

What Alumni Value from New Product Development Education: A Longitudinal Study

ERIC Educational Resources Information Center

Cobb, Corie L.; Hey, Jonathan; Agogino, Alice M.; Beckman, Sara L.; Kim, Sohyeong

2016-01-01

We present a longitudinal study of what graduates take away from a cross-disciplinary graduate-level New Product Development (NPD) course at UC Berkeley over a 15-year period from 1996-2010. We designed and deployed a longitudinal survey and interviewed a segment of our NPD alumni population to better understand how well our course prepared these…

Partnering with K-12 Education in Building Healthy, Sustainable, and Competitive Regions: A California Policy Symposium. Proceedings Summary & Next Steps

ERIC Educational Resources Information Center

Vincent, Jeff; McKoy, Deborah; Alex, Ken; Mitchell, Connie; Moore, Kathleen

2013-01-01

On December 6, 2012, UC Berkeley's Center for Cities & Schools, in collaboration with the California Department of Education, California Department of Public Health, Governor's Office of Planning and Research, Strategic Growth Council, and Health in All Policies Task Force, brought together leaders from across California to discuss the…

Teaching with Stereoscopic Video: Opportunities and Challenges

NASA Astrophysics Data System (ADS)

Variano, Evan

2017-11-01

I will present my work on creating stereoscopic videos for fluid pedagogy. I discuss a variety of workflows for content creation and a variety of platforms for content delivery. I review the qualitative lessons learned when teaching with this material, and discuss outlook for the future. This work was partially supported by the NSF award ENG-1604026 and the UC Berkeley Student Technology Fund.

NASA Space Astronomy Update 6: Unconventional Windows on the Universe

NASA Technical Reports Server (NTRS)

1992-01-01

Professor Stu Bowyer (University of California at Berkeley) explains the Extreme Ultraviolet Explorer and its telescope in this video. Both instrument and satellite are kept in perfect working condition. The satellite picks up extra galactic objects outside our galaxy.

Carbon Nanotube Membranes for Water Purification

NASA Astrophysics Data System (ADS)

Bakajin, Olgica

2009-03-01

Carbon nanotubes are an excellent platform for the fundamental studies of transport through channels commensurate with molecular size. Water transport through carbon nanotubes is also believed to be similar to transport in biological channels such as aquaporins. I will discuss the transport of gas, water and ions through microfabricated membranes with sub-2 nanometer aligned carbon nanotubes as ideal atomically-smooth pores. The measured gas flow through carbon nanotubes exceeded predictions of the Knudsen diffusion model by more than an order of magnitude. The measured water flow exceeded values calculated from continuum hydrodynamics models by more than three orders of magnitude and is comparable to flow rates extrapolated from molecular dynamics simulations and measured for aquaporins. More recent reverse osmosis experiments reveal ion rejection by our membranes. Based on our experimental findings, the current understanding of the fundamentals of water and gas transport and of ion rejection will be discussed. The potential application space that exploits these unique nanofluidic phenomena will be explored. The extremely high permeabilities of these membranes, combined with their small pore size will enable energy efficient filtration and eventually decrease the cost of water purification.[4pt] In collaboration with Francesco Fornasiero, Biosciences and Biotechnology Division, PLS, LLNL, Livermore, CA 94550; Sangil Kim, NSF Center for Biophotonics Science & Technology, University of California at Davis, Sacramento CA 95817; Jung Bin In, Mechanical Engineering Department, UC Berkeley, Berkeley CA 94720; Hyung Gyu Park, Jason K Holt, and Michael Stadermann, Biosciences and Biotechnology Division, PLS, LLNL; Costas P. Grigoropoulos, Mechanical Engineering Department, UC Berkeley; Aleksandr Noy, Biosciences and Biotechnology Division, PLS, LLNL and School of Natural Sciences, University of California at Merced.

ARC-2009-ACD09-0055-002

NASA Image and Video Library

2009-04-08

Directors Colloquium: Science Seminar by John Coates, Associate Professor of Microbiology at the University of California, Berkeley, on Microbial Perchlorate Reduction. The discovery of perchlorate in soils at the Phoenix Landing site, makes this type of organisms interesting analogues to potential life on Mars.

ARC-2009-ACD09-0055-005

NASA Image and Video Library

2009-04-08

Directors Colloquium: Science Seminar by John Coates, Associate Professor of Microbiology at the University of California, Berkeley, on Microbial Perchlorate Reduction. The discovery of perchlorate in soils at the Phoenix Landing site, makes this type of organisms interesting analogues to potential life on Mars.

ARC-2009-ACD09-0055-004

NASA Image and Video Library

2009-04-08

Directors Colloquium: Science Seminar by John Coates, Associate Professor of Microbiology at the University of California, Berkeley, on Microbial Perchlorate Reduction. The discovery of perchlorate in soils at the Phoenix Landing site, makes this type of organisms interesting analogues to potential life on Mars.

ARC-2009-ACD09-0055-003

NASA Image and Video Library

2009-04-08

Directors Colloquium: Science Seminar by John Coates, Associate Professor of Microbiology at the University of California, Berkeley, on Microbial Perchlorate Reduction. The discovery of perchlorate in soils at the Phoenix Landing site, makes this type of organisms interesting analogues to potential life on Mars.

ARC-2009-ACD09-0055-001

NASA Image and Video Library

2009-04-08

Directors Colloquium: Science Seminar by John Coates, Associate Professor of Microbiology at the University of California, Berkeley, on Microbial Perchlorate Reduction. The discovery of perchlorate in soils at the Phoenix Landing site, makes this type of organisms interesting analogues to potential life on Mars.

Extinction of the Dinosuars: Scientific Theory

NASA Technical Reports Server (NTRS)

Moreno, M. A.

1993-01-01

Professor Luis Alvarez, a doctor in physics, of the University of California, Berkeley, proposed in 1980 the theory that an asteroid of 10 kilometers in diameter traveling at more than 100,000 kilometers per hour collided with the earth 65 million years ago causing the extenction of the dinosaurs.

Interview with Deborah Nolan

ERIC Educational Resources Information Center

Rossman, Allan; Nolan, Deborah

2015-01-01

Deborah Nolan is Professor of Statistics and holds the Zaffaroni Family Chair in Undergraduate Education at the University of California-Berkeley, where she has also served as Associate Dean of Mathematical and Physical Sciences. She is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics. This interview…

Cloud Computing: Virtual Clusters, Data Security, and Disaster Recovery

NASA Astrophysics Data System (ADS)

Hwang, Kai

Dr. Kai Hwang is a Professor of Electrical Engineering and Computer Science and Director of Internet and Cloud Computing Lab at the Univ. of Southern California (USC). He received the Ph.D. in Electrical Engineering and Computer Science from the Univ. of California, Berkeley. Prior to joining USC, he has taught at Purdue Univ. for many years. He has also served as a visiting Chair Professor at Minnesota, Hong Kong Univ., Zhejiang Univ., and Tsinghua Univ. He has published 8 books and over 210 scientific papers in computer science/engineering.

Linking Perceptions of School Belonging to Academic Motivation and Academic Achievement amongst Student Athletes: A Comparative Study between High-Revenue Student Athletes and Non-Revenue Student Athletes

ERIC Educational Resources Information Center

Anderson, Christine Marie

2010-01-01

In this study, I examined the relationship that exists among school belonging, achievement motivation, and academic achievement in a sample of student-athletes at UC Berkeley. The goal of the study was to achieve a deeper understanding of how and why achievement motivation and academic achievement is often discrepant between revenue and…

THz Solar Observations on Board of a Trans-Antarctic Stratospheric Balloon Flight

NASA Technical Reports Server (NTRS)

Kaufmann, P.; Abrantes, A.; Bortolucci, E. C.; Caspi, A.; Fernandes, L. O. T.; Kropotov, G.; Kudaka, A. S.; Laurent, G.; Machado, N.; Marcon, R.;

Future Generation Network Architecture (New Arch)

DTIC Science & Technology

2004-06-01

Laboratory/IFKF, Rome NY. Other, unfunded, participants in the project included the UC Berkeley ICSI Center for Internet Research (Mark Handley), and an...developed in the late 1970s under DARPA’s Internet research program. The global technical principles, or architecture, of the Internet design represented a...wide range of key aspects of the basic architecture, in search of unifying principles. The success of the original DARPA Internet research program

The Management of Intercollegiate Athletics at UC Berkeley: Turning Points and Consequences. Research & Occasional Paper Series: CSHE.12.13

ERIC Educational Resources Information Center

Cummins, John; Hextrum, Kirsten

2013-01-01

This white paper was prepared at the request of the Advisory Committee to the Athletic Study Center as a result of their concern over poor graduation rates in football as released by the NCAA in 2012. The paper received extensive review by the members of that committee as well as several other knowledgeable faculty and senior administrators before…

A New Campus Built on Efficiency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harding, Ari; Mercado, Andrea; Regnier, Cindy

2015-08-01

The University of California (UC), Merced partnered with the U.S. Department of Energy (DOE) to develop and implement solutions to reduce energy consumption by as part of DOE’s Commercial Buildings Partnerships (CBP) Program. Lawrence Berkeley National Laboratory (LBNL) provided technical expertise in support of this DOE program. This case study reports on the process and outcome of this project including the achieved savings from design improvements for the campus. The intent of the project was to retrofit the Science & Engineering (S&E) building and the central plant at UC Merced to achieve up to 30% energy reduction. The anticipated savingsmore » from these retrofits represented about 17% of whole-campus energy use. If achieved, the savings contribution from the CBP project would have brought overall campus performance to 56% of the 1999 UC/CSU benchmark performance for their portfolio of buildings. However, the final design that moved forward as part of the CBP program only included the retrofit measures for the S&E building.« less

University Technology Transfer: In Tough Economic Times

ERIC Educational Resources Information Center

Powers, Joshua B.; Campbell, Eric G.

2009-01-01

In 1907, Frederick Cottrell, professor of chemistry at the University of California-Berkeley and father of the modern academic patent, worried that if universities became too directly involved in patenting and licensing operations, their thirst for profits could lead to the erosion of the openness necessary for academic science to flourish. For…

Q & A with Ed Tech Leaders: Interview with Marcia C. Linn

ERIC Educational Resources Information Center

Fulgham, Susan M.; Shaughnessy, Michael F.

2014-01-01

Susan M. Fulgham and Michael F. Shaughnessy, Contributing Editors for this journal, present their interview with Marcia C. Linn, Professor of Development and Cognition, specializing in education in mathematics, science, and technology, in the Graduate School of Education at the University of California, Berkeley. Linn is currently investigating…

Harold F. Weaver: California Astronomer

NASA Astrophysics Data System (ADS)

Shields, J. C.

1993-05-01

This talk will give an overview of an oral history recently completed with Harold F. Weaver, Professor Emeritus of Astronomy at the University of California at Berkeley. Weaver grew up in California and studied as an undergraduate at Berkeley, where he also pursued graduate work incorporating research at Lick and Mount Wilson Observatories. After pursuing postdoctoral research at Yerkes Observatory and war work in Cambridge (Massachusetts) and Berkeley, Weaver was appointed to the staff of Lick Observatory. In 1951 he joined the faculty at Berkeley, where he later played a major role in founding Hat Creek Radio Observatory. As Director of the Berkeley Radio Astronomy Laboratory, Weaver oversaw construction of the 85-foot telescope at Hat Creek, which is the subject of a special session at this meeting. Two aspects of Weaver's career will be highlighted. The first is the somewhat unusual and very successful transition in Weaver's observational research from emphasis on classical photographic techniques at optical wavelengths to use of emerging radio technology for the study of Galactic structure. The second is service provided by Weaver to the American Astronomical Society and Astronomical Society of the Pacific at several key junctures in the development of both organizations.

Astronomy in the Classroom for Mature Lifelong Learners

NASA Astrophysics Data System (ADS)

Cobb, B. E.

2010-08-01

Mature adults are sometimes underserved by the professional astronomical community, which often focuses on K-12/undergraduate education and outreach. Mature adults hold as much interest and enthusiasm for astronomy as their younger cohorts, but often face a greater challenge in obtaining access to adult-level information that is more structured than sporadic public lectures or the occasional popular-science article. I present here my efforts to bring astronomy classes to the Osher Lifelong Learning Institute (OLLI) at UC Berkeley. There are over 120 OLLIs on university and college campuses throughout the United States. These institutes provide adults, age 50 and above, with both a diverse curriculum of study and a stimulating community of peers. Teaching at OLLI has been a straightforward way so share astronomy with this segment of the public—outreach that could be replicated by astronomers at other universities and colleges with associated OLLIs. The OLLI classroom can be challenging because of the wide range of student educational backgrounds. However, teaching at OLLI is extremely rewarding because mature adults bring to the classroom a vast array of life experiences, great curiosity, and immense independence of thought. The OLLI also provides the unique opportunity to inspire other non-traditional astronomy outreach activities by building partnerships both with professors in other disciplines and with the students themselves, as adult students often have the resources and connections to call upon to further explore and share astronomy outside the classroom.

Immobilization of Radionuclides Through Anaerobic Bio-oxidation of Fe(ll)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, John D.

2005-06-01

Over the last year we have focused our efforts on two independent aspects (a) further investigation of the microbiology and geochemistry of nitrate-dependent Fe(II) oxidation and (b) assembling the sequenced genome of Dechloromonas aromatica strain RCB. This work has been performed in a cooperative fashion amongst the independent labs of the three PI's with the UC Berkeley lab taking the lead under the guidance of J.D. Coates.

Dynamic Geometry Capture with a Multi-View Structured-Light System

DTIC Science & Technology

2014-12-19

funding was never a problem during my studies . One of the best parts of my time at UC Berkeley has been working with colleagues within the Video and...scientific and medical applications such as quantifying improvement in physical therapy and measuring unnatural poses in ergonomic studies . Specifically... cases with limited scene texture. This direct generation of surface geometry provides us with a distinct advantage over multi-camera based systems. For

Managing Objects in a Relational Framework

DTIC Science & Technology

1989-01-01

Database Week, San Jose CA, May.1983, pp.107-113. [Stonebraker 85] Stonebraker,M. and Rowe,L.: "The Design of POSTGRES " Tech.Report UC Berkeley, Nov...latter is equivalent to the definition of an attribute in a POSTGRES relation using the generic Quel facility. Recently, recursive query languages have...utilize rewrite rules. OSQL [Lynl 88] provides a language for associative access. 2. The POSTGRES model [Sto 86] allows Quel and C-procedures as the

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The 2013 International Sherwood Fusion Theory Conference was held in Santa Fe, NM from April 15-17. There were 15 invited talks spanning the field of fusion theory on topics such as stellerator theory, intrinsic rotation in tokamaks, transport in the plasma edge, and plasma-wall interactions. Author-provided summaries of several of the invited talks are included on pages 5 to 10 of this document. Plenary talks were given by Per Helander (Max-Planck-Institut fuer Plasmaphysik, Greifswald, Germany) on “Overview of recent developments in stellerator theory”, Amit Misra (Los Alamos National Laboratory) on “Stable storage of Helium at interfaces in nanocomposites”, Sergei Krasheninnikovmore » (UC San Diego) on “On the physics of the first wall in fusion devices”, and Stuart Bale (UC Berkeley) on “Solar wind thermodynamics and turbulence: collisional – collisionless transitions”.« less

Supernovae, Dark Energy and the Accelerating Universe: How DOE Helped to Win (yet another) Nobel Prize

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perlmutter, Saul

2012-01-13

The Department of Energy (DOE) hosted an event Friday, January 13, with 2011 Physics Nobel Laureate Saul Perlmutter. Dr. Perlmutter, a physicist at the Department’s Lawrence Berkeley National Laboratory and a professor of physics at the University of California at Berkeley, won the 2011 Nobel Prize in Physics “for the discovery of the accelerating expansion of the Universe through observations of distant supernovae.” DOE’s Office of Science has supported Dr. Perlmutter’s research at Berkeley Lab since 1983. After the introduction from Secretary of Energy Steven Chu, Dr. Perlmutter delivered a presentation entitled "Supernovae, Dark Energy and the Accelerating Universe: Howmore » DOE Helped to Win (yet another) Nobel Prize." [Copied with editing from DOE Media Advisory issued January 10th, found at http://energy.gov/articles/energy-department-host-event-2011-physics-nobel-laureate-saul-perlmutter]« less

George Lakoff's New Happiness: Politics after Rationality

ERIC Educational Resources Information Center

Parrott, John B.

2009-01-01

Berkeley professor of linguistics and cognitive science George Lakoff is among the handful of current faculty members in the United States to have successfully recast himself as a significant figure in national politics. Though his views place rather far on the progressive left, he has, unlike some other scholar-activists, focused most of his…

"Torture Memos" vs. Academic Freedom

ERIC Educational Resources Information Center

Glenn, David

2009-01-01

When people gathered last May for the commencement ceremony at the University of California at Berkeley's Boalt Hall School of Law, they were greeted by chanting activists from the National Lawyers Guild and other left-wing groups. The university, protesters shouted, should fire John C. Yoo, a tenured professor who has taught at the law school…

Discussion panel: field test design & data analysis

Treesearch

Daniel M. Schmitt; William E. Waters; B. Leo Cadogan; Gerald S. Walton

1985-01-01

I think it is time to open the panel. On my left respectively are Bill Waters, Professor of Entomology and Forestry, University of California, Berkeley; Gerald S. Walton, Biometrician, Northeastern Forest Experiment Station, Hamden; and Leo Cadogan, Forest Pest Management Institute, Canadian Forestry Service, Sault Ste. Marie, Ontario. My name is Dan Schmitt, Program...

The Institute for School Administrators: A Program for Professional and Personal Growth. Conceptualization and Assessment.

ERIC Educational Resources Information Center

Reed, Rodney J.

The annual Institute for School Administrators, founded on Maslow's hierarchy of needs and Knowles' theory of adult learning, was initiated in 1979 at the University of California, Berkeley. After identifying participants' needs, a panel of school administrators and university professors develop the annual program. The Institute's general goals…

A Conversation with Uri Treisman

ERIC Educational Resources Information Center

Treisman, Uri

2012-01-01

Dr. Uri Treisman, professor of mathematics and public affairs at The University of Texas at Austin and the director of the Charles A. Dana Center, has deep and active roots in mathematics and mathematics education. Dr. Treisman is well known for his early work at the University of California at Berkeley, where he developed the Calculus Workshop…

Nurturing Brain Development from Birth to 3

ERIC Educational Resources Information Center

Gopnik, Alison

2012-01-01

Alison Gopnik, PhD, a researcher and professor at the University of California, Berkeley, responds to questions about the ways researchers are discovering the complex processes of early cognitive development. Dr. Gopnik shares some of the creative research methods that are demonstrating how infants are figuring out what is going on in the mind of…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Little, G.A.

For better than ten years there was little public notice of the TRIGA reactor at UC-Berkeley. Then: a) A non-student persuaded the Student and Senate to pass a resolution to request Campus Administration to stop operation of the reactor and remove it from campus. b) Presence of the reactor became a campaign-issue in a City Mayoral election. c) Two local residents reported adverse physical reactions before, during, and after a routine tour of the reactor facility. d) The Berkeley City Council began a study of problems associated with radioactive material within the city. e) Friends Of The Earth formally petitionedmore » the NRC to terminate the reactor's license. Campus personnel have expended many man-hours and many pounds of paper in responding to these happenings. Some of the details are of interest, and may be of use to other reactor facilities. (author)« less

Second user workshop on high-power lasers at the Linac Coherent Light Source

DOE PAGES

Heimann, Phil; Glenzer, Siegfried

2015-05-28

The second international workshop on the physics enabled by the unique combination of high-power lasers with the world-class Linac Coherent Light Source (LCLS) free-electron X-ray laser beam was held in Stanford, CA, on October 7–8, 2014. The workshop was co-organized by UC Berkeley, Lawrence Berkeley, Lawrence Livermore, and SLAC National Accelerator Laboratories. More than 120 scientists, including 40 students and postdoctoral scientists who are working in high-intensity laser-matter interactions, fusion research, and dynamic high-pressure science came together from North America, Europe, and Asia. The focus of the second workshop was on scientific highlights and the lessons learned from 16 newmore » experiments that were performed on the Matter in Extreme Conditions (MEC) instrument since the first workshop was held one year ago.« less

Optical design and optical properties of a VUV spectrographic imager for ICON mission

NASA Astrophysics Data System (ADS)

Loicq, Jerome; Kintziger, Christian; Mazzoli, Alexandra; Miller, Tim; Chou, Cathy; Frey, Harald U.; Immel, Thomas J.; Mende, Stephen B.

2016-07-01

In the frame of the ICON (Ionospheric Connection Explorer) mission of NASA led by UC Berkeley, CSL and SSL Berkeley have designed in cooperation a new Far UV spectro-imager. The instrument is based on a Czerny-Turner spectrograph coupled with two back imagers. The whole field of view covers [+/- 12° vertical, +/- 9° horizontal]. The instrument is surmounted by a rotating mirror to adjust the horizontal field of view pointing by +/- 30°. To meet the scientific imaging and spectral requirements the instrument has been optimized. The optimization philosophy and related analysis are presented in the present paper. PSF, distortion map and spectral properties are described. A tolerance study and alignment cases were performed to prove the instrument can be built and aligned. Finally straylight and out of band properties are discussed.

Do Babies Matter? The Effect of Family Formation on Men and Women in Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mary Ann Mason

2007-10-30

Mary Ann Mason, Professor of Social Welfare and Law at the University of California, Berkeley, presents "Do Babies Matter? The Effect of Family Formation on Men and Women in Science." In her talk, she discusses the difficulties of women who have a career in science or in other male-dominated professions.

A Research Career at a Liberal-Arts College

ERIC Educational Resources Information Center

Ghodsee, Kristen

2008-01-01

Many professors and graduate students finishing their Ph.D.'s at the University of California at Berkeley scoffed at the idea of a post at a liberal-arts college. To them it was considered an acceptable choice only if none of the jobs at research universities came through. Liberal-arts colleges were viewed merely as teaching institutions and did…

Specific Inhibitors of Histone Demethylases: Novel Chemical Agents for Breast Cancer Therapy

DTIC Science & Technology

2011-08-01

S. Ng, K. L. Kavanagh, M. A. McDonough, D. Butler , E. S. Pilka, B. M. R. Lienard, J. E. Bray, P. Savitsky, O. Gileadi, F. von Delft, N. R. Rose, J...University of California, Berkeley Postdoctoral Advisor: Professor Judith P. Klinman AWARDS AND HONORS  Ralph E. Powe Junior Faculty Award, Oak

From Students to Change Agents: The 2009 K. Patricia Cross Future Leaders Awards

ERIC Educational Resources Information Center

Change: The Magazine of Higher Learning, 2009

2009-01-01

One of the author's chief delights as editor of "Change" is to read, every year, the personal statements of students who have won the K. Patricia Cross Future Leaders Award. Pat Cross, professor "emerita" at the University of California, Berkeley, has long been a leading scholar in higher education. These future leaders of…

Do Babies Matter? The Effect of Family Formation on Men and Women in Science

ScienceCinema

Mary Ann Mason

2017-12-09

Mary Ann Mason, Professor of Social Welfare and Law at the University of California, Berkeley, presents "Do Babies Matter? The Effect of Family Formation on Men and Women in Science." In her talk, she discusses the difficulties of women who have a career in science or in other male-dominated professions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bachan, John

Chisel is a new open-source hardware construction language developed at UC Berkeley that supports advanced hardware design using highly parameterized generators and layered domain-specific hardware languages. Chisel is embedded in the Scala programming language, which raises the level of hardware design abstraction by providing concepts including object orientation, functional programming, parameterized types, and type inference. From the same source, Chisel can generate a high-speed C++-based cycle-accurate software simulator, or low-level Verilog designed to pass on to standard ASIC or FPGA tools for synthesis and place and route.

Electro-Magnetic Actuated Valve for MEMS Fuel Metering System

DTIC Science & Technology

2007-09-01

This model is utilized material properties of Silicon (Si), Copper (Cu), Nickel Iron ( NiFe ), and air. C11 Air NiSe Figure 5. Design of a simplified a... NiFe are defined and shown table 4. It is assumed that the properties of materials are independent of orientation (i.e. isotropic materials). Relative...dry filn resist. This process enables an integrated NiFe armature with a hole-in-the-wall within the main flow channel. UC Berkeley, Pisano - 2007

Supernovae, Dark Energy and the Accelerating Universe: How DOE Helped to Win (yet another) Nobel Prize

ScienceCinema

Perlmutter, Saul; Chu, Steven

2018-05-31

The Department of Energy (DOE) hosted an event Friday, January 13, with 2011 Physics Nobel Laureate Saul Perlmutter. Dr. Perlmutter, a physicist at the Department’s Lawrence Berkeley National Laboratory and a professor of physics at the University of California at Berkeley, won the 2011 Nobel Prize in Physics “for the discovery of the accelerating expansion of the Universe through observations of distant supernovae.” DOE’s Office of Science has supported Dr. Perlmutter’s research at Berkeley Lab since 1983. After the introduction from Secretary of Energy Steven Chu, Dr. Perlmutter delivered a presentation entitled "Supernovae, Dark Energy and the Accelerating Universe: How DOE Helped to Win (yet another) Nobel Prize." [Copied with editing from DOE Media Advisory issued January 10th, found at http://energy.gov/articles/energy-department-host-event-2011-physics-nobel-laureate-saul-perlmutter

An academic genealogy on the history of American field primatologists.

PubMed

Kelley, Elizabeth A; Sussman, Robert W

2007-03-01

In this paper, we present the academic genealogy of American field primatologists. The genealogy has been compiled to formally document the historical record of this young field. Data have been collected from three main sources: 1) e-mail surveys, 2) library and Internet research, and 3) verbal communication through forums such as American Association of Physical Anthropology meetings. Lineages of primatologists have been graphically displayed using Microsoft Visio. As of September 2005, 672 names and 239 affiliated universities, organizations and institutions have been recorded in 19 lineages. Five hundred and thirty-eight of the 672 names, 80.1%, are field primatologists. The Hooton/Washburn lineage is the largest; 60.6% of the recorded field primatologists are linked to this lineage. In addition, four of the five professors who have mentored a comparable number of field primatologists at American universities since Washburn are linked to the Hooton/Washburn lineage; and the school where Washburn mentored a majority of his students, UC-Berkeley, continues to have the highest overall graduation record for this subdiscipline. However, the field of primatology has been diversifying since the 1960s, and different universities are now responsible for graduating a substantial number of primatologists. We conclude that while the Hooton/Washburn lineage has remained remarkably homogenous in its anthropological focus, the field is also becoming increasingly enriched by primatologists who have had training in fields such as zoology, psychology, and ecology both in the United States and abroad. (c) 2006 Wiley-Liss, Inc.

2006 Long Range Development Plan Final Environmental ImpactReport

DOE Office of Scientific and Technical Information (OSTI.GOV)

Philliber, Jeff

2007-01-22

This environmental impact report (EIR) has been prepared pursuant to the applicable provisions of the California Environmental Quality Act (CEQA) and its implementing guidelines (CEQA Guidelines), and the Amended University of California Procedures for Implementation of the California Environmental Quality Act (UC CEQA Procedures). The University of California (UC or the University) is the lead agency for this EIR, which examines the overall effects of implementation of the proposed 2006 Long Range Development Plan (LRDP; also referred to herein as the 'project' for purposes of CEQA) for Lawrence Berkeley National Laboratory (LBNL; also referred to as 'Berkeley Lab,' 'the Laboratory,'more » or 'the Lab' in this document). An LRDP is a land use plan that guides overall development of a site. The Lab serves as a special research campus operated by the University employees, but it is owned and financed by the federal government and as such it is distinct from the UC-owned Berkeley Campus. As a campus operated by the University of California, the Laboratory is required to prepare an EIR for an LRDP when one is prepared or updated pursuant to Public Resources Code Section 21080.09. The adoption of an LRDP does not constitute a commitment to, or final decision to implement, any specific project, construction schedule, or funding priority. Rather, the proposed 2006 LRDP describes an entire development program of approximately 980,000 gross square feet of new research and support space construction and 320,000 gross square feet of demolition of existing facilities, for a total of approximately 660,000 gross square feet of net new occupiable space for the site through 2025. Specific projects will undergo CEQA review at the time proposed to determine what, if any, additional review is necessary prior to approval. As described in Section 1.4.2, below, and in Chapter 3 of this EIR (the Project Description), the size of the project has been reduced since the Notice of Preparation for this EIR was issued. This reduction was in response to consultation with the City of Berkeley as well as other factors. CEQA requires that, before a decision can be made by a state or local government agency to approve a project that may have significant environmental effects, an EIR must be prepared that fully describes the environmental effects of the project. The EIR is a public informational document for use by University decision-makers and the public. It is intended to identify and evaluate potential environmental consequences of the proposed project, to identify mitigation measures that would lessen or avoid significant adverse impacts, and to examine feasible alternatives to the project. The information contained in the EIR is reviewed and considered by the lead agency prior to its action to approve, disapprove, or modify the proposed project.« less

Dissemination of Research: Your Interface with the Public

NASA Astrophysics Data System (ADS)

McCann, S.; Scotchmoor, J. G.; Lindberg, D.; Kissack, A.

2011-12-01

In January 2011, something very special happened on the UC Berkley campus as a result of a unique partnership between two organizations - KQED, a San Francisco public broadcaster and a public university, UC Berkeley. Nineteen graduate students from the UCB Department of Integrative Biology (IB) and Department of Environmental Science, Policy and Management participated in a pilot project in which they were trained by media professionals in communicating their science to broader audiences. The class, called Dissemination of Research: Your Interface with the Public, was a two unit, seven week course on making media for science communication, a hands-on approach to the dos and don'ts of social media, blogging, photo collections, web media, video/audio interviews, visualizing data, and a survey of types of science media and journalism. The partnership itself was an extension of a project initiated by KQED in 2007. At that time, KQED launched QUEST, with the goal of contributing much needed reporting on science and the environment to Northern California audiences. The project combined an interdisciplinary media staff to create radio reports, television programming, original online media, and educator resources. Further supporting this innovative editorial framework were 16 partners including Northern California's leading science centers, museums, parks, and community-based groups. Among those partners were representatives from UC Berkeley's Natural History Museums and the Integrative Biology Department. The very name - Integrative Biology - reflects the focus of the department which brings together a diversity of disciplines that complement one another to unravel the complexity of biology thus a perfect match for the QUEST project. Building on the model developed for QUEST partner media making trainings, KQED and UC Berkeley decided to pilot a new venture by co-teaching a course, specifically aimed at helping graduate students communicate their science. Unlike similar courses that provide skills in writing press releases and tips for interviews, this one emphasized the making of media. Such a focus teaches students appropriate media formats for differing audiences and which factors make a presentation interesting and comprehensible. The course, beyond media training, required students to contribute to a weekly blog by writing about contemporary scientific research with the goal of making these findings relevant to an everyday audience. Students also produced a one-minute slide show combining photos, animation, music and narration to communicate their own research projects and areas of interest. At the end of the course, an evaluation was conducted to measure the usefulness of the class. Students rated the overall educational value of the course a 6.438 out of 7. They appreciated the interaction with media experts and the different perspectives about communicating science beyond that of scientists. In their words: "It is part of our job as scientists to be able to share our discoveries with the world and we never get trained on this, so we make a lot of mistakes."

Converting Advances in Seismology into Earthquake Science

NASA Astrophysics Data System (ADS)

Hauksson, Egill; Shearer, Peter; Vidale, John

2004-01-01

Federal and state agencies and university groups all operate seismic networks in California. The U.S. Geological Survey (USGS) operates seismic networks in California in cooperation with the California Institute of Technology (Caltech) in southern California, and the University of California (UC) at Berkeley in northern California. The California Geological Survey (CGS) and the USGS National Strong Motion Program (NSMP) operate dial-out strong motion instruments in the state, primarily to capture data from large earthquakes for earthquake engineering and, more recently, emergency response. The California Governor's Office of Emergency Services (OES) provides leadership for the most recent project, the California Integrated Seismic Network (CISN), to integrate all of the California efforts, and to take advantage of the emergency response capabilities of the seismic networks. The core members of the CISN are Caltech, UC Berkeley, CGS, USGS Menlo Park, and USGS Pasadena (http://www.cisn.org). New seismic instrumentation is in place across southern California, and significant progress has been made in improving instrumentation in northern California. Since 2001, these new field instrumentation efforts, data sharing, and software development for real-time reporting and archiving have been coordinated through the California Integrated Seismic Network (CISN). The CISN is also the California region of the Advanced National Seismic Network (ANSS). In addition, EarthScope deployments of USArray that will begin in early 2004 in California are coordinated with the CISN. The southern and northern California earthquake data centers (SCEDC and NCEDC) have new capabilities that enable seismologists to obtain large volumes of data with only modest effort.

Nuclear Spectroscopic Telescope Array (NuSTAR) Mission

NASA Technical Reports Server (NTRS)

Kim, Yunjin; Willis, Jason; Dodd, Suzanne; Harrison, Fiona; Forster, Karl; Craig, William; Bester, Manfred; Oberg, David

2013-01-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) is a National Aeronautics and Space Administration (NASA) Small Explorer mission that carried the first focusing hard X-ray (6-79 keV) telescope into orbit. It was launched on a Pegasus rocket into a low-inclination Earth orbit on June 13, 2012, from Reagan Test Site, Kwajalein Atoll. NuSTAR will carry out a two-year primary science mission. The NuSTAR observatory is composed of the X-ray instrument and the spacecraft. The NuSTAR spacecraft is three-axis stabilized with a single articulating solar array based on Orbital Sciences Corporation's LEOStar-2 design. The NuSTAR science instrument consists of two co-aligned grazing incidence optics focusing on to two shielded solid state CdZnTe pixel detectors. The instrument was launched in a compact, stowed configuration, and after launch, a 10-meter mast was deployed to achieve a focal length of 10.15 m. The NuSTAR instrument provides sub-arcminute imaging with excellent spectral resolution over a 12-arcminute field of view. The NuSTAR observatory will be operated out of the Mission Operations Center (MOC) at UC Berkeley. Most science targets will be viewed for a week or more. The science data will be transferred from the UC Berkeley MOC to a Science Operations Center (SOC) located at the California Institute of Technology (Caltech). In this paper, we will describe the mission architecture, the technical challenges during the development phase, and the post-launch activities.

A Conversation with Robert F. Christy Part I

NASA Astrophysics Data System (ADS)

Lippincott, Sara

2006-09-01

Robert F. Christy, Institute Professor of Theoretical Physics Emeritus at Caltech, recalls his childhood in British Columbia; his undergraduate years at the University of British Columbia; his graduate work with J. Robert Oppenheimer at Berkeley; and his work on the Manhattan Project, first with Enrico Fermi at the Metallurgical Laboratory of the University of Chicago and then as a member of the Theoretical Division at Los Alamos.

Cyber Security: A Crisis of Prioritization

DTIC Science & Technology

2005-02-01

Society (CITRIS) and Professor University of California, Berkeley J. Carter Beese , Jr. President Riggs Capital Partners Pedro Celis, Ph.D. Software...Science University of North Carolina at Chapel Hill William J. Hannigan President AT&T Jonathan C. Javitt, M.D., M.P.H. Senior Fellow Potomac Institute...CHAIR F. Thomson Leighton MEMBERS J. Carter Beese , Jr. Patricia Thomas Evans Luis E. Fiallo Harold Mortazavian David A. Patterson Alice G

PREFACE: 21st International Conference on Laser Spectroscopy - ICOLS 2013

NASA Astrophysics Data System (ADS)

Budker, Dmitry; Häffner, Hartmut; Müller, Holger

2013-12-01

The 21st International Conference on Laser Spectroscopy (ICOLS) took place at Berkeley, California on 9-14 June 2013. Following the tradition of previous meetings in this series, the conference featured about thirty invited talks broadly covering this burgeoning field of science that refuses to show any sign of saturation after more than half a century of continuous boom. In addition to the invited talks, there were two informative poster sessions, where the more than 300 ICOLS participants had an opportunity to exchange the latest scientific news and ideas while enjoying the gorgeous view of the San Francisco Bay from the vista of the Claremont Hotel, the meeting's venue. The heights of the cultural program of the meeting were excursions to several of the Bay Area gems (including the Lick observatory), as well as the conference banquet where the participants were treated to addresses by an inventor of the laser Professor Charles H Townes, a nonlinear optics pioneer Professor Erwin L Hahn, and one of the previous ICOLS chairs Professor Y R Shen. While the field of Laser Spectroscopy and the series of the bi-annual ICOLS meetings are as 'healthy' as one could imagine, the same cannot be said about the concept of published conference proceedings. With new ways to publish scientific articles and preprints, submitting papers to conference proceedings seems to be rapidly losing popularity. For this meeting, the great interest in attendance and opportunities to present is sharply contrasted with a somewhat sluggish response to the call for submission of the proceedings papers. The present collection represents a dozen or so contributions from the 'hero' invited speakers, to whom we are deeply grateful for submitting their work. We hope that this selection will faithfully convey to the readers the excitement of modern laser spectroscopy. In addition to these papers, we draw the reader's attention to the audio recordings and selected viewgraphs from the invited talks, and videos of the reception and banquet presentations available at the conference web site https://icols.berkeley.edu/. On behalf of the organizing and program committees, Berkeley, October 2013 Dmitry Budker, Hartmut Häffner, and Holger Müller

The Berkeley Instrumental Neutron Generator (BINGE) for 40Ar/39Ar geochronology

NASA Astrophysics Data System (ADS)

Renne, P. R.; Becker, T. A.; Bernstein, L.; Firestone, R. B.; Kirsch, L.; Leung, K. N.; Rogers, A.; Van Bibber, K.; Waltz, C.

2014-12-01

The Berkeley Instrumental Neutron Generator (BINGE) facility is the product of a consortium involving the Berkeley Geochronology Center (BGC), the U.C. Berkeley Nuclear Engineering Dept. (UCB/NE), and Lawrence Berkeley (LBNL) and Lawrence Livermore (LLNL) National Labs. BINGE was initially designed (and funded by NSF) for 40Ar/39Ar geochronology. BINGE uses a plasma-based deuteron ion source and a self-loading Ti-surfaced target to induce deuteron-deuterium (DD) fusion via the reaction 2H(d,n)3He, producing 2.45 MeV neutrons. The limited neutron energy spectrum is aimed at reducing recoil effects, interfering nuclear reactions, and unwanted radioactive byproducts, all of which are undesirable consequences of conventional irradiation with 235U fission spectrum neutrons. Minimization of interfering reactions such as 40Ca(n,na)36Ar greatly reduces penalties for over-irradiation, enabling improved signal/background measurement of e.g. 39Ar. BINGE will also be used for a variety of nuclear physics and engineering experiments that require a high flux of monoenergetic neutrons. Neutron energies lower than 2.45 MeV can be obtained via irradiation ports within and external to polyethylene shielding. Initial commissioning produced a neutron flux of 108 n/sec/cm2 at 1 mA source current and 100 kV anode voltage, as expected. When scaled up to the 1 A source current as planned, this indicates that BINGE will achieve the design objective neutron flux of 1011 n/sec/cm2. Further progress towards this goal will be reported. Supported by NSF (grant #EAR-0960138), BGC, UCB/NE, University of California Office of the President, and DOE through LLNL under contract #DE-AC52-07NA27344 and LBNL under contract #DE-AC02-05CH11231.

Security Force Assistance: Cases and Policy

DTIC Science & Technology

2018-02-02

Biddle, Stephen (Principal Investigator) Berman, Eli (Co-PI) National Bureau of Economic Research, Inc. 1050 Massachusetts Ave. Cambridge, MA...2 February 2018 Sponsoring organization: Office of Naval Research (ONR) Performing organization: National Bureau of Economic Research, Inc...Professor and Chair of Economics , University of California San Diego, and Research Director for International Security Studies at the UC Institute

Design of monocular head-mounted displays for increased indoor firefighting safety and efficiency

NASA Astrophysics Data System (ADS)

Wilson, Joel; Steingart, Dan; Romero, Russell; Reynolds, Jessica; Mellers, Eric; Redfern, Andrew; Lim, Lloyd; Watts, William; Patton, Colin; Baker, Jessica; Wright, Paul

2005-05-01

Four monocular Head-Mounted Display (HMD) prototypes from the Fire Information and Rescue Equipment (FIRE) project at UC Berkeley are presented. The FIRE project aims to give firefighters a system of information technology tools for safer and more efficient firefighting in large buildings. The paper begins by describing the FIRE project and its use of a custom wireless sensor network (WSN) called SmokeNet for personnel tracking. The project aims to address urban/industrial firefighting procedures in need of improvement. Two "user-needs" studies with the Chicago and Berkeley Fire Departments are briefly presented. The FIRE project"s initial HMD prototype designs are then discussed with regard to feedback from the user-needs studies. These prototypes are evaluated in their potential costs and benefits to firefighters and found to need improvement. Next, some currently available commercial HMDs are reviewed and compared in their cost, performance, and potential for use by firefighters. Feedback from the Berkeley Fire Department user-needs study, in which the initial prototypes were demonstrated, is compiled into a concept selection matrix for the next prototypes. This matrix is used to evaluate a variety of HMDs, including some of the commercial units presented, and to select the best design options. Finally, the current prototypes of the two best design options are presented and discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Auslander, David; Culler, David; Wright, Paul

The goal of the 2.5 year Distributed Intelligent Automated Demand Response (DIADR) project was to reduce peak electricity load of Sutardja Dai Hall at UC Berkeley by 30% while maintaining a healthy, comfortable, and productive environment for the occupants. We sought to bring together both central and distributed control to provide “deep” demand response1 at the appliance level of the building as well as typical lighting and HVAC applications. This project brought together Siemens Corporate Research and Siemens Building Technology (the building has a Siemens Apogee Building Automation System (BAS)), Lawrence Berkeley National Laboratory (leveraging their Open Automated Demand Responsemore » (openADR), Auto-­Demand Response, and building modeling expertise), and UC Berkeley (related demand response research including distributed wireless control, and grid-­to-­building gateway development). Sutardja Dai Hall houses the Center for Information Technology Research in the Interest of Society (CITRIS), which fosters collaboration among industry and faculty and students of four UC campuses (Berkeley, Davis, Merced, and Santa Cruz). The 141,000 square foot building, occupied in 2009, includes typical office spaces and a nanofabrication laboratory. Heating is provided by a district heating system (steam from campus as a byproduct of the campus cogeneration plant); cooling is provided by one of two chillers: a more typical electric centrifugal compressor chiller designed for the cool months (Nov-­ March) and a steam absorption chiller for use in the warm months (April-­October). Lighting in the open office areas is provided by direct-­indirect luminaries with Building Management System-­based scheduling for open areas, and occupancy sensors for private office areas. For the purposes of this project, we focused on the office portion of the building. Annual energy consumption is approximately 8053 MWh; the office portion is estimated as 1924 MWh. The maximum peak load during the study period was 1175 kW. Several new tools facilitated this work, such as the Smart Energy Box, the distributed load controller or Energy Information Gateway, the web-­based DR controller (dubbed the Central Load-­Shed Coordinator or CLSC), and the Demand Response Capacity Assessment & Operation Assistance Tool (DRCAOT). In addition, an innovative data aggregator called sMAP (simple Measurement and Actuation Profile) allowed data from different sources collected in a compact form and facilitated detailed analysis of the building systems operation. A smart phone application (RAP or Rapid Audit Protocol) facilitated an inventory of the building’s plug loads. Carbon dioxide sensors located in conference rooms and classrooms allowed demand controlled ventilation. The extensive submetering and nimble access to this data provided great insight into the details of the building operation as well as quick diagnostics and analyses of tests. For example, students discovered a short-­cycling chiller, a stuck damper, and a leaking cooling coil in the first field tests. For our final field tests, we were able to see how each zone was affected by the DR strategies (e.g., the offices on the 7th floor grew very warm quickly) and fine-­tune the strategies accordingly.« less

Where do California's greenhouse gases come from?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, Marc

2009-12-11

Last March, more than two years after California passed legislation to slash greenhouse gas emissions 25 percent by 2020, Lawrence Berkeley National Laboratory scientist Marc Fischer boarded a Cessna loaded with air monitoring equipment and crisscrossed the skies above Sacramento and the Bay Area. Instruments aboard the aircraft measured a cocktail of greenhouse gases: carbon dioxide from fossil fuel use, methane from livestock and landfills, CO2 from refineries and power plants, traces of nitrous oxide from agriculture and fuel use, and industrially produced other gases like refrigerants. The flight was part of the Airborne Greenhouse Gas Emissions Survey, a collaborationmore » between Berkeley Lab, the National Oceanic and Atmospheric Administration, and the University of California, and UC Davis to pinpoint the sources of greenhouse gases in central California. The survey is intended to improve inventories of the states greenhouse gas emissions, which in turn will help scientists verify the emission reductions mandated by AB-32, the legislation enacted by California in 2006.« less

BEARS: a multi-mission anomaly response system

NASA Astrophysics Data System (ADS)

Roberts, Bryce A.

2009-05-01

The Mission Operations Group at UC Berkeley's Space Sciences Laboratory operates a highly automated ground station and presently a fleet of seven satellites, each with its own associated command and control console. However, the requirement for prompt anomaly detection and resolution is shared commonly between the ground segment and all spacecraft. The efficient, low-cost operation and "lights-out" staffing of the Mission Operations Group requires that controllers and engineers be notified of spacecraft and ground system problems around the clock. The Berkeley Emergency Anomaly and Response System (BEARS) is an in-house developed web- and paging-based software system that meets this need. BEARS was developed as a replacement for an existing emergency reporting software system that was too closedsource, platform-specific, expensive, and antiquated to expand or maintain. To avoid these limitations, the new system design leverages cross-platform, open-source software products such as MySQL, PHP, and Qt. Anomaly notifications and responses make use of the two-way paging capabilities of modern smart phones.

Honors

NASA Astrophysics Data System (ADS)

The following AGU members have been elected as members to the National Academy of Sciences. Election to membership in the Academy is considered one of the highest honors that can be accorded a U.S. scientist or engineer.Sallie W. Chisholm is Lee and Geraldine Martin Professor of Environmental Studies, and co-director of the Earth System Initiative at the Massachusetts Institute of Technology, Cambridge.Jody W. Deming is professor of biological oceanography at the University of Washington, Seattle.James H. Dieterich is senior research scientist of the Earthquake Hazards Team at the U. S. Geological Survey, Menlo Park, California.William E. Dietrich is professor in the Department of Earth and Planetary Sciences at the University of California, Berkeley.Lennard A. Fisk is professor and chair in the Department of Atmospheric, Oceanic, and Space Sciences at the University of Michigan, Ann Arbor.Isaac M. Held is senior research scientist and head of the Climate Dynamics Group at the National Oceanic and Atmospheric Administration, Princeton, New Jersey.Judith L. Lean is a research physicist in the Space Science Division at the Naval Research Laboratory, Washington, D.C.Edward L. Miles is Virginia and Prentice Bloedel Professor of Marine and Public Affairs at the University of Washington, Seattle.William H. Schlesinger is James B. Duke Professor of Biogeochemistry and dean of the Nicholas School of the Environment and Earth Sciences at Duke University, Durham, North Carolina.

Features and dimensions of the Hayward Fault Zone in the Strawberry and Blackberry Creek Area, Berkeley, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, P.L.

1995-03-01

This report presents an examination of the geometry of the Hayward fault adjacent to the Lawrence Berkeley Laboratory and University of California campuses in central Berkeley. The fault crosses inside the eastern border of the UC campus. Most subtle geomorphic (landform) expressions of the fault have been removed by development and by the natural processes of landsliding and erosion. Some clear expressions of the fault remain however, and these are key to mapping the main trace through the campus area. In addition, original geomorphic evidence of the fault`s location was recovered from large scale mapping of the site dating frommore » 1873 to 1897. Before construction obscured and removed natural landforms, the fault was expressed by a linear, northwest-tending zone of fault-related geomorphic features. There existed well-defined and subtle stream offsets and beheaded channels, fault scarps, and a prominent ``shutter ridge``. To improve our confidence in fault locations interpreted from landforms, we referred to clear fault exposures revealed in trenching, revealed during the construction of the Foothill Housing Complex, and revealed along the length of the Lawson Adit mining tunnel. Also utilized were the locations of offset cultural features. At several locations across the study area, distress features in buildings and streets have been used to precisely locate the fault. Recent published mapping of the fault (Lienkaemper, 1992) was principally used for reference to evidence of the fault`s location to the northwest and southeast of Lawrence Berkeley Laboratory.« less

Designing a connectionist network supercomputer.

PubMed

Asanović, K; Beck, J; Feldman, J; Morgan, N; Wawrzynek, J

1993-12-01

This paper describes an effort at UC Berkeley and the International Computer Science Institute to develop a supercomputer for artificial neural network applications. Our perspective has been strongly influenced by earlier experiences with the construction and use of a simpler machine. In particular, we have observed Amdahl's Law in action in our designs and those of others. These observations inspire attention to many factors beyond fast multiply-accumulate arithmetic. We describe a number of these factors along with rough expressions for their influence and then give the applications targets, machine goals and the system architecture for the machine we are currently designing.

Evaluation of the Program in Medical Education for the Urban Underserved (PRIME-US) at the UC Berkeley-UCSF Joint Medical Program (JMP): The First 4 Years.

PubMed

Sokal-Gutierrez, Karen; Ivey, Susan L; Garcia, Roxanna M; Azzam, Amin

2015-01-01

Medical educators, clinicians, and health policy experts widely acknowledge the need to increase the diversity of our healthcare workforce and build our capacity to care for medically underserved populations and reduce health disparities. The Program in Medical Education for the Urban Underserved (PRIME-US) is part of a family of programs across the University of California (UC) medical schools aiming to recruit and train physicians to care for underserved populations, expand the healthcare workforce to serve diverse populations, and promote health equity. PRIME-US selects medical students from diverse backgrounds who are committed to caring for underserved populations and provides a 5-year curriculum including a summer orientation, a longitudinal seminar series with community engagement and leadership-development activities, preclerkship clinical immersion in an underserved setting, a master's degree, and a capstone rotation in the final year of medical school. This is a mixed-methods evaluation of the first 4 years of the PRIME-US at the UC Berkeley-UC San Francisco Joint Medical Program (JMP). From 2006 to 2010, focus groups were conducted each year with classes of JMP PRIME-US students, for a total of 11 focus groups; major themes were identified using content analysis. In addition, 4 yearly anonymous, online surveys of all JMP students, faculty and staff were conducted and analyzed. Most PRIME-US students came from socioeconomically disadvantaged backgrounds and ethnic backgrounds underrepresented in medicine, and all were committed to caring for underserved populations. The PRIME-US students experienced many program benefits including peer support, professional role models and mentorship, and curricular enrichment activities that developed their knowledge, skills, and sustained commitment to care for underserved populations. Non-PRIME students, faculty, and staff also benefited from participating in PRIME-sponsored seminars and community-based activities. Challenges noted by PRIME-US students and non-PRIME students, faculty, and staff included the stress of additional workload, perceived inequities in student educational opportunities, and some negative comments from physicians in other specialties regarding primary care careers. Over the first 4 years of the program, PRIME-US students and non-PRIME students, faculty, and staff experienced educational benefits consistent with the intended program goals. Long-term evaluation is needed to examine the participants' medical careers and impacts on California's healthcare workforce and patient outcomes. Attention should also be paid to the challenges of implementing new medical education enrichment programs.

Careers in Data Science: A Berkeley Perspective

NASA Astrophysics Data System (ADS)

Koy, K.

2015-12-01

Last year, I took on an amazing opportunity to serve as the Executive Director of the new Berkeley Institute for Data Science (BIDS). After a 15-year career working with geospatial data to advance our understanding of the environment, I have been presented with a unique opportunity through BIDS to work with talented researchers from a wide variety of backgrounds. Founded in 2013, BIDS is a central hub of research and education at UC Berkeley designed to facilitate and nurture data-intensive science. We are building a community centered on a cohort of talented data science fellows and senior fellows who are representative of the world-class researchers from across our campus and are leading the data science revolution within their disciplines. Our initiatives are designed to bring together broad constituents of the data science community, including domain experts from the life, social, and physical sciences and methodological experts from computer science, statistics, and applied mathematics. While many of these individuals rarely cross professional paths, BIDS actively seeks new and creative ways to engage and foster collaboration across these different research fields. In this presentation, I will share my own story, along with some insights into how BIDS is supporting the careers of data scientists, including graduate students, postdocs, faculty, and research staff. I will also describe how these individuals we are helping support are working to address a number of data science-related challenges in scientific research.

Nailing Pompeii

NASA Astrophysics Data System (ADS)

Showstack, Randy

Roman hihstorian Pliny the Younger noted that Mount Vesuvius blew its top and destroyed Pompeii in the early afternoon of August 24, 1,918 years ago. Now, a team of scientists, tempted by the certainty of that record, has confirmed the eruption to within 7 years. The team developed and used an improved radioactive argon-argon dating technique, which they say can reliably establish the age of rocks as old as the solar system or as recent as 1,000 years old.“We nailed the date to 5% on our first attempt, so we could probably get the error down to 1% or less,” says Paul Renne, adjunct associate professor of geology and geophysics at the University of California at Berkeley and director of the private Berkeley Geochronology Center. “Dating things that are really young has always been the Holy Grail of potassium-argon [an earlier method] and argonargon dating.”

Web site lets solar scientists inform and inspire students

NASA Astrophysics Data System (ADS)

Hauck, Karin

2012-07-01

Where on the Web can a middle school girl ask a female solar scientist about solar storms, the course and behavior of charged solar particles, and the origin of the Sun's dynamo—and also find out what the scientist was like as a child, whether the scientist has tattoos or enjoys snowboarding, what she likes and dislikes about her career, and how she balances her energy for work and family life? These kinds of exchanges happen at Solar Week (http://www.solarweek.org; see Figure 1). Established in 2000, Solar Week is an online resource for middle and lower high school students about the science of the Sun, sponsored by the Center for Science Education at the Space Sciences Laboratory (CSE@SSL) at the University of California, Berkeley (UC Berkeley). The Web site's goals are to educate students about the Sun and solar physics and to encourage future careers in science—especially for girls. One way is by giving solar scientists the chance to be relatable role models, to answer students' questions, and to share their experiences in an online forum.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elbridge Gerry Puckett

All of the work conducted under the auspices of DE-FC02-01ER25473 was characterized by exceptionally close collaboration with researchers at the Lawrence Berkeley National Laboratory (LBNL). This included having one of my graduate students - Sarah Williams - spend the summer working with Dr. Ann Almgren a staff scientist in the Center for Computational Sciences and Engineering (CCSE) which is a part of the National Energy Research Supercomputer Center (NERSC) at LBNL. As a result of this visit Sarah decided to work on a problem suggested by Dr. John Bell the head of CCSE for her PhD thesis, which she finishedmore » in June 2007. Writing a PhD thesis while working at one of the University of California (UC) managed DOE laboratories is a long established tradition at the University of California and I have always encouraged my students to consider doing this. For example, in 2000 one of my graduate students - Matthew Williams - finished his PhD thesis while working with Dr. Douglas Kothe at the Los Alamos National Laboratory (LANL). Matt is now a staff scientist in the Diagnostic Applications Group in the Applied Physics Division at LANL. Another one of my graduate students - Christopher Algieri - who was partially supported with funds from DE-FC02-01ER25473 wrote am MS Thesis that analyzed and extended work published by Dr. Phil Colella and his colleagues in 1998. Dr. Colella is the head of the Applied Numerical Algorithms Group (ANAG) in the National Energy Research Supercomputer Center at LBNL and is the lead PI for the APDEC ISIC which was comprised of several National Laboratory research groups and at least five University PI's at five different universities. Chris Algieri is now employed as a staff member in Dr. Bill Collins' research group at LBNL developing computational models for climate change research. Bill Collins was recently hired at LBNL to start and be the Head of the Climate Science Department in the Earth Sciences Division at LBNL. Prior to this he had been a Deputy Section Head at the National Center for Atmospheric Research in Colorado. My understanding is that Chris Algieri is the first person that Bill hired after coming to LBNL. The plan is that Chris Algieri will finish his PhD thesis while employed as a staff scientist in Bill's group. Both Sarah and Chris were supported in part with funds from DE-FC02-01ER25473. In Sarah's case she received support both while at U.C. Davis (UCD) taking classes and writing an MS thesis and during some of the time she was living in Berkeley, working at LBNL and finishing her PhD thesis. In Chris' case he was at U.C. Davis during the entire time he received support from DE-FC02-01ER25473. More specific details of their work are included in the report below. Finally my own research conducted under the auspices of DE-FC02-01ER25473 either involved direct collaboration with researchers at LBNL - Phil Colella and Peter Schwartz who is a member of Phil's Applied Numerical Algorithms Group - or was on problems that are closely related to research that has been and continues to be conducted by researchers at LBNL. Specific details of this work can be found below. Finally, I would like to note that the work conducted by my students and me under the auspices of this contract is closely related to work that I have performed with funding from my DOE MICS contract DE-FC02-03ER25579 'Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting' and with my CoPI on that grant Professor Greg Miller of the Department of Applied Science at UCD. In theory I tried to use funds from the SciDAC grant DE-FC02-01ER25473 to support work that directly involved implementing algorithms developed by my research group at U.C. Davis in software that was developed and is maintained by my SciDAC CoPI's at LBNL.« less

Eclipse Megamovie 2017: A Citizen Science Project

NASA Astrophysics Data System (ADS)

Johnson, C.; Koh, J.; Konerding, D.; Peticolas, L. M.; Hudson, H. S.; Martinez Oliveros, J. C.; Zevin, D.

2017-12-01

The 2017 total solar eclipse presents an amazing opportunity for education and science outreach due to the breadth and reach of this astronomical event. The Eclipse Megamovie project looks to create organize a citizen science effort to capture images of the eclipse as it crosses the US and stitch these photos together into a continuous look at the corona. A collaboration between Google, UC Berkeley, and many other universities and amateur astronomy networks, this project looks to leverage the different strenghts of these organizations and capitalize on this rare outreach opportunity. We're excited to present the results of the project and a review of how things went.

Seaborg's plutonium? A case study in nuclear forensics

DOE PAGES

Norman, Eric B.; Thomas, Keenan J.; Telhami, Kristina E.

2015-10-01

Passive X-ray and gamma-ray analysis was performed on a curious sample from UC Berkeley's Hazardous Material Facility inventory, and the object was found to contain 239Pu. No other radioactive isotopes were observed. The mass of 239Pu contained in this object was determined to be 2.0 ± 0.3 μg. These observations are consistent with the identification of this object as containing the 2.77-μg PuO2 (2.44 μg 239Pu) sample produced in 1942 and described by Seaborg and his collaborators as the first sample of 239Pu that was large enough to be weighed.

Characterization of BOR-60 Irradiated 14YWT-NFA1 Tubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saleh, Tarik A.; Maloy, Stuart Andrew; Aydogan, Eda

2017-02-15

Tubes of FCRD 14YWT-NFA1 Alloy were placed in the BOR-60 reactor and irradiated under a fast flux neutron environment to two conditions: 7 dpa at 360-370 °C and 6 dpa at 385-430 °C. Small sections of the tube were cut and sent to UC Berkeley for nanohardness testing and focused ion beam (FIB) milling of TEM specimens. FIB specimens were sent back to LANL for final FIB milling and TEM imaging. Hardness data and TEM images are presented in this report. This is the first fast reactor neutron irradiated information on the 14YWT-NFA1 alloy.

It is Time to Rescind Don’t Ask, Don’t Tell

DTIC Science & Technology

2009-04-02

cohesion and that in turn would affect accomplishing the mission. A study done at UC, Davis, makes a distinction between social cohesion and task...cohesion.22 Social cohesion is the nature and quality of emotional bonds of friendship, closeness, etc. and task cohesion is a shared commitment among...studies of cohesion and performance it is task cohesion, not social cohesion or group pride that drives group performance. Professor MacCoun also

Hayward Fault rate constraints at Berkeley: Evaluation of the 335-meter Strawberry Creek offset

NASA Astrophysics Data System (ADS)

Williams, P. L.

2007-12-01

At UC Berkeley the active channel of Strawberry Creek is offset 335 meters by the Hayward fault and two abandoned channels of Strawberry Creek are laterally offset 580 and 730 meters. These relationships record the displacement of the northern Hayward fault at Berkeley over a period of tens of millennia. The Strawberry Creek site has a similar geometry to the central San Andreas fault's Wallace Creek site, which arguably provides the best geological evidence of "millennial" fault kinematics in California (Sieh and Jahns, 1984). Slip rate determinations are an essential component of overall hazard evaluation for the Hayward fault, and this site is ripe to disclose a long-term form of this parameter, to contrast with geodetic and other geological rate evidence. Large offsets at the site may lower uncertainty in the rate equation relative to younger sites, as the affect of stream abandonment age, generally the greatest source of rate uncertainty, is greatly reduced. This is helpful here because it more-than-offsets uncertainties resulting from piercing projections to the fault. Strawberry Creek and its ancestral channels suggest west-side-up vertical deformation across the Hayward fault at this location. The development of the vertical deformation parameter will complement ongoing geodetic measurements, particularly InSAR, and motivate testing of other geological constraints. Up-to-the-west motion across the Hayward fault at Berkeley has important implications for the partitioning of strain and kinematics of the northern Hayward fault, and may explain anomalous up-on-the-west landforms elsewhere along the fault. For example, geological features of the western Berkeley Hills are consistent with rapid and recent uplift to the west of the fault. On the basis of a preliminary analysis of the offset channels of Strawberry Creek, up-to-the-west uplift is about 0.5mm/yr across the Hayward fault at Berkeley. If this is in fact the long-term rate, the 150 m height of the Hills to the northwest of the Strawberry Creek site was produced during the past about 300,000 years by a significant dip- slip (thrust) component of Hayward fault motion. Rapid and recent uplift of some portions of the East Bay Hills has important implications for fault geometries and slope stability, and should strongly influence the investigation fault hazards in areas that are more complexly deformed.

1985 VGP Awards

NASA Astrophysics Data System (ADS)

Carmichael, I. S. E.; Hildreth, Wes; Peterson, Donald W.; Fisher, Richard; Schmincke, Hans-Ulrich

We are here to acknowledge Wes Hildreth's researches on silicic magmatism. His celebrated account of the Bishop Tuff, now eponymous, is the most extensively analyzed and influential rock mass since the Skaergaard intrusion and, for its detail and significance, has become the yardstick of silicic petrology; yet his study is less than 7 years old.Edward Wesley Hildreth III was born in 1938, and as the English would say, attended Harvard College in 1956. In 1961, he graduated cum laude with a major in geology, a minor in government, and a travelling scholarship to see the world. For the next 10 years he did so and became a naturalist in the U.S. National Park Service, with periods in Death Valley and in the Olympics. His “Death Valley Days” were to return, forthrough his love of the Panamint Ranges he met Mitch Reynolds, then an assistant professor at [the University of California] Berkeley, and in 1971 he arrived in Berkeley as a new graduate student, anxious and impatient to unravel the structure of the Panamints.

Development of a biophotonics technician-training program: directions for the 21st Century

NASA Astrophysics Data System (ADS)

Shackelford, James F.; Gellman, Joel; Vasan, Srini; Hall, Robert A.; Goodwin, Don E.; Molinaro, Marco; Matthews, Dennis

2005-06-01

Albuquerque Technical Vocational Institute (TVI) is collaborating with the National Science Foundation (NSF) funded Center for Biophotonics Science and Technology (CBST) headquartered at the University of California, Davis in order to develop a biophotonics curriculum for community colleges nationwide. TVI began the formal collaboration to bring about critically needed training and education that will ultimately create new jobs and employment opportunities in the field of biophotonics. "Biophotonics" is the science of generating and harnessing light to detect, image and manipulate biological materials. CBST chose TVI as a partner because of the Institute's current high-level photonics and biotechnology programs. In addition, TVI is a part of the "Albuquerque Model" that involves exposure to photonics education from the middle school level through graduate education at the University of New Mexico. Three middle schools feed into the West Mesa High School Photonics Academy, whose students then move on to TVI for advanced training. CBST brings together scientists, industry, educators and the community to research and develop applications for biophotonics. Roughly 100 researchers-including physical scientists, life scientists, physicians and engineers from UC Davis, Lawrence Livermore National Laboratory, UC Berkeley, UC San Francisco, Alabama A&M University, Stanford University, University of Texas at San Antonio, Fisk University and Mills College-are collaborating in this rapidly developing area of research. Applications of biophotonics range from using light to image or selectively treat tumors, to sequencing DNA and identifying single biomolecules within cells.

Footprint of Sandia's August 15 2016 Informal Idea Exploration Session on "Towards an Engineering and Applied Science of Research".

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsao, Jeffrey Y.; Fleming Lindsley, Elizabeth S.; Heffelfinger, Grant S.

On August 15, 2016, Sandia hosted a visit by Professor Venkatesh Narayanamurti. Prof Narayanamurti (Benjamin Peirce Research Professor of Technology and Public Policy at Harvard, Board Member of the Belfer Center for Science and International Affairs, former Dean of the School of Engineering and Applied Science at Harvard, former Dean of Engineering at UC Santa Barbara, and former Vice President of Division 1000 at Sandia). During the visit, a small, informal, all-day idea exploration session on "Towards an Engineering and Applied Science of Research" was conducted. This document is a brief synopsis or "footprint" of the presentations and discussions atmore » this Idea Exploration Session. The intent of this document is to stimulate further discussion about pathways Sandia can take to improve its Research practices.« less

Ancient Earth, Alien Earths Event

NASA Image and Video Library

2014-08-20

Dr. Dawn Sumner, Professor of Geology, UC Davis, speaks on a panel at the “Ancient Earth, Alien Earths” Event at NASA Headquarters in Washington, DC Wednesday, August 20, 2014. The event was sponsored by NASA, the National Science Foundation (NSF), and the Smithsonian Institution and was moderated by Dr. David H. Grinspoon, Senior Scientist at the Planetary Science Institute. Six scientists discussed how research on early Earth could help guide our search for habitable planets orbiting other stars. Photo Credit: (NASA/Aubrey Gemignani)

Ancient Earth, Alien Earths Event

NASA Image and Video Library

2014-08-20

Dr. Timothy Lyons, Professor of Biogeochemistry, UC Riverside, speaks on a panel at the “Ancient Earth, Alien Earths” Event at NASA Headquarters in Washington, DC Wednesday, August 20, 2014. The event was sponsored by NASA, the National Science Foundation (NSF), and the Smithsonian Institution and was moderated by Dr. David H. Grinspoon, Senior Scientist at the Planetary Science Institute. Six scientists discussed how research on early Earth could help guide our search for habitable planets orbiting other stars. Photo Credit: (NASA/Aubrey Gemignani)

Characteristic coupling time between axial and transverse energy modes for anti-hydrogen in magnetostatic traps

NASA Astrophysics Data System (ADS)

Zhong, Mike; Fajans, Joel

2016-10-01

For upcoming ALPHA collaboration laser spectroscopy and gravity experiments, the nature of the chaotic trajectories of individual antihydrogen atoms trapped in the octupole Ioffe magnetic trap is of importance. Of particular interest for experimental design is the coupling time between the axial and transverse modes of energy for the antihydrogen atoms. Using Monte Carlo simulations of semiclassical dynamics of antihydrogen trajectories, we quantify this characteristic coupling time between axial and transverse modes of energy. There appear to be two classes of trajectories: for orbits whose axial energy is higher than 10% of the total energy, the axial energy varies chaotically on the order of 1-10 seconds, whereas for orbits whose axial energy is around 10% of the total energy, the axial energy remains nearly constant on the order of 1000 seconds or longer. Furthermore, we search through parameter -space to find parameters of the magnetic trap that minimize and maximize this characteristic coupling time. This work was supported by the UC Berkeley Summer Undergraduate Research Fellowship, the Berkeley Research Computing program, the Department of Energy contract DE-FG02-06ER54904, and the National Science Foundation Grant 1500538-PHY.

Automation of the 1.3-meter Robotically Controlled Telescope (RCT)

NASA Astrophysics Data System (ADS)

Gelderman, Richard; Treffers, Richard R.

2011-03-01

This poster describes the automation for the Robotically Controlled Telescope (RCT) Consortium of the 50-inch telescope at Kitt Peak National Observatory. Building upon the work of the previous contractor the telescope, dome and instrument were wired for totally autonomous (robotic) observations. The existing motors, encoders, limit switches and cables were connected to an open industrial panel that allows easy interconnection, troubleshooting and modifications. A sixteen axis Delta Tau Turbo PMAC controller is used to control all motors, encoders, flat field lights and many of the digital functions of the telescope. ADAM industrial I/O bricks are used for additional digital and analog I/O functions. Complex relay logic problems, such as the mirror cover opening sequence and the slit control, are managed using Allen Bradley Pico PLDs. Most of the low level software is written in C using the GNU compiler. The basic functionality uses an ASCII protocol communicating over Berkeley sockets. Early versions of this software were developed at U.C. Berkeley, for what was to become the Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory. ASCII communications are useful for control, testing and easy to debug by looking at the log files; C-shell scripts are written to form more complex orchestrations.

Editorial development

NASA Astrophysics Data System (ADS)

Wileman, Chris

2013-01-01

We are delighted to announce that from January 2013, Professor Edgar Knobloch of the University of California, Berkeley, USA, will be the new co-Editor-in-Chief of Nonlinearity, joining current co-Editor-in-Chief Professor Anatoly Neishtadt. Edgar comes to the position with a wealth of experience, including a spell as a valued member of the Editorial Board of Nonlinearity, and wide respect from across the nonlinear science community. We very much look forward to working with Edgar to continue to develop the journal's high standards of quality and interest to the readership. Whilst welcoming Edgar to the position, we would also like to extend our gratitude to Professor Jon Keating for his tremendous contribution to Nonlinearity during his time as co-Editor-in-Chief. Jon joined the journal in 1997 as a member of the Editorial Board, taking over as co-Editor-in-Chief in 2004. Throughout his time as both a member of the Editorial Board and as a co-Editor-in-Chief, Jon worked tirelessly to uphold the highest quality standards and to ensure that Nonlinearity is a place where researchers can both read and publish the most stimulating work in nonlinear science. His joint leadership with Professor Anatoly Neishtadt has seen Nonlinearity continue from strength to strength. Jon will be sorely missed. On behalf of the London Mathematical Society, Institute of Physics and the entire Editorial Board we wish him all the best in the future.

Sarnoff A. Mednick (1928-2015).

PubMed

Cannon, Tyrone; Moffitt, Terrie; Brennan, Patricia; Raine, Adrian; Baker, Laura

2016-01-01

Presents the obituary of Sarnoff A. Mednick (1928 -2015). Sarnoff A. Mednick was considered among the most important figures in psychopathology research in his generation. He pioneered the high-risk research design and made numerous contributions to our understanding of creativity and of the origins of schizophrenia and criminality. The son of Jewish immigrants, Mednick was born on January 27, 1928, and was raised in the Bronx in New York City, New York. He earned a bachelor's degree from the City College of New York in 1948 and a master's degree from Columbia University. In 1954, he earned his doctorate in psychology from Northwestern University. Following a postdoctoral fellowship at the University of Chicago, he was appointed an instructor at Harvard University and then became a visiting assistant research professor at the University of California, Berkeley (1958 -1959). In 1968, he became a professor at the New School for Social Research in New York, where he taught until 1977, when he joined the faculty at the University of Southern California until his retirement in August 2008. Mednick, professor emeritus of psychology at the University of Southern California, died of natural causes on April 10, 2015, in Toledo, Ohio. He was 87. (c) 2016 APA, all rights reserved).

Successful ShakeAlert Performance for the Napa Quake

NASA Astrophysics Data System (ADS)

Allen, R. M.; Given, D. D.; Heaton, T. H.; Vidale, J. E.

2014-12-01

ShakeAlert, the demonstration earthquake early warning system, developed by the USGS, UC Berkeley, Caltech, ETH, and the University of Washington, functioned as expected for the August 24, 2014, M6.0 Napa earthquake. The first ShakeAlert was generated by the ElarmS algorithm 5.1 sec after the origin time of the earthquake, and 3.3 sec after the P-wave arrived at the closest station 6.5 km from the epicenter. This initial alert, based on P-wave triggers from four stations, estimated the magnitude to be 5.7. The warning was received at the UC Berkeley Seismological Laboratory 5 seconds before the S-wave and about 10 sec prior to the onset of the strongest shaking. ShakeAlert beta-testers across the San Francisco Bay Area simultaneously received the alert, including the San Francisco 911 center with 8 sec warning, and the BART train system. BART has implemented an automated train-stopping system that was activated (although no trains were running at 3:20 am). With the available network geometry and communications, the blind zone of the first alert had a radius of 16 km. The four stations that contributed to the first alert all encapsulate data into 1-second packets, but the latency in transmitting data to the processing center ranged from 0.27 to 2.62 seconds. If all the stations were to deliver data in 0.27 seconds, then the alert would have been available 2.3 sec sooner and the blind zone would be reduced to about 8 km. This would also mean that the city of Napa would have received about 1 second of warning. The magnitude estimate and event location were accurate from the initial alert onwards. The magnitude estimate did first increase to 5.8 and then dip to 5.4 2.6 sec after the initial alert, stayed at that level for 2 sec, and then returned to 5.7. The final magnitude estimate was 6.0, consistent with the ANSS catalog.

KPF: Keck Planet Finder

NASA Astrophysics Data System (ADS)

Gibson, Steven R.; Howard, Andrew W.; Marcy, Geoffrey W.; Edelstein, Jerry; Wishnow, Edward H.; Poppett, Claire L.

2016-08-01

KPF is a fiber-fed, high-resolution, high-stability spectrometer in development at the UC Berkeley Space Sciences Laboratory for the W.M. Keck Observatory. The instrument is designed to characterize exoplanets via Doppler spectroscopy with a single measurement precision of 0.5ms-1 or better, however its resolution and stability will enable a wide variety of astrophysical pursuits. KPF will have a 200mm collimated beam diameter and a resolving power of >80,000. The design includes a green channel (440nm to 590 nm) and red channel (590nm to 850 nm). A novel design aspect of KPF is the use of a Zerodur optical bench, and Zerodur optics with integral mounts, to provide stability against thermal expansion and contraction effects.

Application of the Software as a Service Model to the Control of Complex Building Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Donadee, Jonathan; Marnay, Chris

2011-03-17

In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building.more » The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analysed.« less

Application of the Software as a Service Model to the Control of Complex Building Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Donadee, Jon; Marnay, Chris

2011-03-18

In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building.more » The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analyzed.« less

The Carbon in Arctic Reservoirs Vulnerability Experiment (CARVE) FTS: Results From the 2012/13 Alaska Campaigns

NASA Astrophysics Data System (ADS)

kurosu, T. P.; Miller, C. E.; Dinardo, S.

2013-12-01

The Carbon in Arctic Reservoirs Vulnerability Experiment (CARVE) is an aircraft-based Earth Venture 1 mission to study the carbon balance of the Alaskan Arctic ecosystem, with a particular focus on carbon release from melting permafrost. Operating from its base in Fairbanks, AK, the CARVE aircraft covers a range of principle flight paths in the Alaskan interior, the Yukon River valley, and northern Alaska coast around Barrow and Dead Horse. Flight paths are chosen to maximize ecosystem variability and and cover burn-recovery/regrowth sequences. CARVE observations cover the Arctic Spring/Summer/Fall seasons, with multiple flights per season and principle flight paths. Science operations started in 05/2012 and are currently envisaged to continue until 2015. The CARVE suite of instruments includes flask measurements and in situ gas analyzers for CO2, CH4 and CO observations, an active/passive L-band radar for surface conditions (freeze/thaw state), and a three-band polarizing Fourier Transform Spectrometer (FTS) for column measurements of CO2, CH4, CO, and interfering species (e.g., H2O). The FTS covers the spectral regions of 4,200-4,900 cm-1 (CH4, CO), 5,800-6,400 cm-1 (CO2), and 12,900-13,200 cm-1 (O2), with a spectral resolution of 0.2 cm-1. Aircraft-based FTS science observations in Alaska have been performed since 23-05-2012. First-version data products from all CARVE instruments derived from observations during the 2012 campaign were publicly released earlier in 2013. The FTS has performed well during flight conditions, particularly with respect to vibration damping. Outstanding challenges include the need for improved spectral and radiometric calibration, as well as compensating for low signal-to-noise spectra acquired under Alaskan flight conditions. We present results from FTS column observations of CO2, CH4, and CO, observed during the 2012 and 2013 campaigns, including preliminary comparisons of CARVE FTS measurements with satellite observations of CO2 from TANSO/GOSAT as well as results from CARVE in situ measurements. CARVE Science Team: L. Bruhwiler, NOAA ESRL I. Fung, UC Berkeley C. Koven, Lawrence Berkeley Laboratory I. Leifer, UC Santa Barbara K. McDonald, CCNY J. Miller, NOAA ESRL W. Oechel, San Diego State University E. Podest, JPL J. Randerson, UC Irvine P. Rayner, Melbourne University D. Rider, JPL C. Sweeney, NOAA ESRL P. Wennberg, Caltech S. Wofsy, Harvard University R. Chang, Harvard University A. Karion, NOAA ESRL T. P. Kurosu, JPL N. Steiner, CCNY J. Henderson, AER J. Fisher, JPL

Indoor Chemical Exposures: Humans' Non-respiratory Interactions with Room Air

ScienceCinema

Charles Weschler

2017-12-09

March 18, 2010 Berkeley Lab Environmental Energy Technology Division distinguished lecture: The marked difference in pollutant concentrations between an occupied and un-occupied room are only partially explained by human bio-effluents. Humans alter levels of ozone and related oxidants such as nitrate and hydroxyl radicals in the rooms they inhabit; in effect, they change the oxidative capacity of room air. Ozone-initiated reactions on exposed skin, hair and clothing generate products, including potentially irritating chemicals whose concentrations are much higher in the occupant's breathing zone than in the core of the room. Charles J. Weschler is a Professor at the School of Public Health, the Department of Environmental and Occupational Medicine and the Environmental and Occupational Health Sciences Institute (EOHSI) at the University of Medicine and Dentistry of New Jersey (UMDNJ)/Robert Wood Johnson Medical School & Rutgers University (New Jersey). He is also a Visiting Professor at the International Centre for Indoor Environment and Energy, Technical University of Denmark (DTU, Lyngby, Denmark).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charles Weschler

March 18, 2010 Berkeley Lab Environmental Energy Technology Division distinguished lecture: The marked difference in pollutant concentrations between an occupied and un-occupied room are only partially explained by human bio-effluents. Humans alter levels of ozone and related oxidants such as nitrate and hydroxyl radicals in the rooms they inhabit; in effect, they change the oxidative capacity of room air. Ozone-initiated reactions on exposed skin, hair and clothing generate products, including potentially irritating chemicals whose concentrations are much higher in the occupant's breathing zone than in the core of the room. Charles J. Weschler is a Professor at the School ofmore » Public Health, the Department of Environmental and Occupational Medicine and the Environmental and Occupational Health Sciences Institute (EOHSI) at the University of Medicine and Dentistry of New Jersey (UMDNJ)/Robert Wood Johnson Medical School & Rutgers University (New Jersey). He is also a Visiting Professor at the International Centre for Indoor Environment and Energy, Technical University of Denmark (DTU, Lyngby, Denmark).« less

Characterization of a Viking Blade Fabricated by Traditional Forging Techniques

NASA Astrophysics Data System (ADS)

Vo, H.; Frazer, D.; Bailey, N.; Traylor, R.; Austin, J.; Pringle, J.; Bickel, J.; Connick, R.; Connick, W.; Hosemann, P.

2016-12-01

A team of students from the University of California, Berkeley, participated in a blade-smithing competition hosted by the Minerals, Metals, and Materials Society at the TMS 2015 144th annual meeting and exhibition. Motivated by ancient forging methods, the UC Berkeley team chose to fabricate our blade from historical smithing techniques utilizing naturally-occurring deposits of iron ore. This approach resulted in receiving the "Best Example of a Traditional Blade Process/Ore Smelting Technique" award for our blade named "Berkelium." First, iron-enriched sand was collected from local beaches. Magnetite (Fe3O4) was then extracted from the sand and smelted into individual high- and low-carbon steel ingots. Layers of high- and low-carbon steels were forge-welded together, predominantly by hand, to form a composite material. Optical microscopy, energy dispersive spectroscopy, and Vickers hardness mechanical testing were conducted at different stages throughout the blade-making process to evaluate the microstructure and hardness evolution during formation. It was found that the pre-heat-treated blade microstructure was composed of ferrite and pearlite, and contained many nonmetallic inclusions. A final heat treatment was performed, which caused the average hardness of the blade edge to increase by more than a factor of two, indicating a martensitic transformation.

Performance of Charcoal Cookstoves for Haiti Part 1: Results from the Water Boiling Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Booker, Kayje; Han, Tae Won; Granderson, Jessica

2011-06-01

In April 2010, a team of scientists and engineers from Lawrence Berkeley National Lab (LBNL) and UC Berkeley, with support from the Darfur Stoves Project (DSP), undertook a fact-finding mission to Haiti in order to assess needs and opportunities for cookstove intervention. Based on data collected from informal interviews with Haitians and NGOs, the team, Scott Sadlon, Robert Cheng, and Kayje Booker, identified and recommended stove testing and comparison as a high priority need that could be filled by LBNL. In response to that recommendation, five charcoal stoves were tested at the LBNL stove testing facility using a modified formmore » of version 3 of the Shell Foundation Household Energy Project Water Boiling Test (WBT). The original protocol is available online. Stoves were tested for time to boil, thermal efficiency, specific fuel consumption, and emissions of CO, CO{sub 2}, and the ratio of CO/CO{sub 2}. In addition, Haitian user feedback and field observations over a subset of the stoves were combined with the experiences of the laboratory testing technicians to evaluate the usability of the stoves and their appropriateness for Haitian cooking. The laboratory results from emissions and efficiency testing and conclusions regarding usability of the stoves are presented in this report.« less

UC Berkeley Nuclear Engineering Curriculum and Research Enhancement. Final report, February 14, 1993--February 14, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fowler, T.K.; Peterson, P.F.

1995-05-11

This is a report for the 2/14/93 to 2/14/95 period of the five-year program proposed and initiated in 1992, for curriculum and research enhancement for the Department of Nuclear Engineering at the University of California, Berkeley. The program is designed to strengthen the departmental academic infrastructure and improve the education breadth of nuclear engineering students. The DOE funds have supported scholarships and a novel educational program which includes summer coursework at the Diablo Canyon Nuclear Power Plant. The summer course provides an important introduction to reactor safety and operations to students who will in the future be responsible for runningmore » many of our existing nuclear power plants. The work was funded under DOE contract DE-FG0393ER75856, with a matching gift to the Department from the Pacific Gas and Electric Company (PG&E). The program described in the original grant proposal has been successful implemented with an enthusiastic response from our students and faculty. The program consisted of two parts, one for innovative additions to our curriculum funded by the DOE, and the other for distinguished lectureships and support for basic research funded by gifts from PG&E.« less

Transforming the diagnosis of tuberculosis: an editorial board member's opinion at the 15th year of Expert Review of Molecular Diagnostics.

PubMed

Pai, Madhukar; Raison, Claire

2015-03-01

Interview with Professor Madhukar Pai, MD, PhD by Claire Raison (Commissioning Editor). Professor Madhukar Pai did his medical training and community medicine residency in Vellore, India. He completed his PhD in epidemiology at the University of California, Berkeley (CA, USA) and a postdoctoral fellowship at the University of California, San Francisco (CA, USA). He is currently an associate professor of epidemiology at McGill University in Montreal (Canada). He serves as the Director of Global Health Programs, and as an Associate Director of the McGill International Tuberculosis Centre. In addition, he serves as a Consultant for the Bill & Melinda Gates Foundation. He also serves on the Scientific Advisory Committee of the Foundation for Innovative New Diagnostics, Geneva, Switzerland. His research is focused on improving the diagnosis and treatment of tuberculosis, especially in high-burden countries such as India and South Africa. His research is supported by grant funding from the Gates Foundation, Grand Challenges Canada and Canadian Institutes of Health Research. He has more than 200 peer-reviewed publications. He is recipient of the Union Scientific Prize, Chanchlani Global Health Research Award and Stars in Global Health award from Grand Challenges Canada, and is a member of the Royal Society of Canada.

Collaborative Research. Atmospheric Pressure Microplasma Chemistry-Photon Synergies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Sung-Jin; Eden, James Gary

Combining the effects of low temperature, atmospheric pressure microplasmas and microplasma photon sources offers the promise of greatly expanding the range of applications for each of them. The plasma sources create active chemical species and these can be activated further by the addition of photons and the associated photochemistry. There are many ways to combine the effects of plasma chemistry and photochemistry, especially if there are multiple phases present. This project combined the construction of appropriate test experimental systems, various spectroscopic diagnostics and mathematical modeling. Through a continuous discussion and co-design process with the UC-Berkeley Team, we have successfully completedmore » the fabrication and testing of all components for a microplasma array-assisted system designed for photon-activated plasma chemistry research. Microcavity plasma lamps capable of generating more than 20 mW/cm 2 at 172 nm (Xe dimer) were fabricated with a custom form factor to mate to the plasma chemistry setup, and a lamp was current being installed by the Berkeley team so as to investigate plasma chemistry-photon synergies at a higher photon energy (~7.2 eV) as compared to the UVA treatment that is afforded by UV LEDs operating at 365 nm. In particular, motivated by the promising results from the Berkeley team with UVA treatment, we also produced the first generation of lamps that can generate photons in the 300-370 nm wavelength range. Another set of experiments, conducted under the auspices of this grant, involved the use of plasma microjet arrays. The combination of the photons and excited radicals produced by the plasma column resulted in broad area deactivation of bacteria.« less

Cooperative Institute for Dynamic Earth Research (CIDER): Contributions to Education (Invited)

NASA Astrophysics Data System (ADS)

Romanowicz, B. A.

2010-12-01

The Cooperative Institute for Dynamic Earth Research (http://www.deep-earth.org) began its activities in 2003 and has so far held four summer programs of duration ranging from 3 to 7 weeks, funded by the NSF/CSEDI program, with support from and at the Kavli Institute for Theoretical Physics in Santa Barbara. CIDER's goals are twofold: (1) as a "synthesis center", to provide an environment for transformative studies of Earth's internal dynamics, requiring a concerted multi-disciplinary effort of leading researchers, and (2) to educate a new generation of Earth scientists with a breadth of competence across the disciplines required to understand the dynamic earth: mineral physics, geodynamics, geochemistry and geomagnetism. CIDER summer programs, so far, have focused on themes related to the Deep Earth: "Reconciling seismic and geochemical heterogeneity in the Earth", "The Earth's transition zone", "Boundary layers in the Earth" and "Fluids and volatiles in the Earth's mantle and core". These programs typically include three weeks of unstructured program designed for senior (assistant professor level and higher) researchers, and a 3-4 weeks "tutorial and workshop" part geared towards advanced graduate students and post-docs, but open also to more senior participants. The first two weeks of the tutorial part include lectures and practical exercises in the different disciplines aimed at providing participants with a basic understanding of the fundamentals and current challenges in disciplines other than their own. During the second week, topics related to the summer program's theme are proposed for further study in a workshop mode by multi-disciplinary groups formed on the fly, continued through the last week or two of the program. These activities often lead to the development of new collaborations and research proposals to the CSEDI program. In 2011, CIDER will hold a summer program at UC Berkeley on the theme "Mountain Building", expanding the scope of the Institute to the shallower parts of our planet.

Circular electrodes to reduce the current variation of OTFTs with the drop-casted semiconducting layer

NASA Astrophysics Data System (ADS)

Dipu Kabir, H. M.; Ahmed, Zubair; Kariyadan, Remashan; Zhang, Lining; Chan, Mansun

2018-06-01

Circular organic thin film transistor (OTFT) structures are proposed to reduce the impact of variable grain alignment on the drive current of the polycrystalline organic thin film transistor (OTFT). As the circular structure is planar symmetric, the orientation of the grain cannot affect the drive current of the circular OTFT. Thus, circular electrodes expected to provide a lower variation. Top-gate, bottom-contact circular and conventional OTFTs with drop-casted polycrystalline 6,13-Bis(triisopropyl-silylethynyl) (TIPS)-Pentacene organic semiconducting layer (OSC) are fabricated to verify the theoretical variation reduction. The relative standard deviation (RSD), defined as the ratio of standard deviation and the average of drive current is used as the degree of variations in different structures. According to our fabrication result, circular transistors have a significantly lower variation (20% RSD), compared to the variation of conventional OTFTs (61% RSD). His research interests include Organic Electronics, VLSI Design, Embedded System, Neural Networks, and Solid-state devices. Between July 2001 and December 2002, he was a Visiting Professor at University of California at Berkeley and the Co-director of the BSIM program. He is currently still consulting on the development of the next generation compact models. He has been actively contributing to the professional community and hold many positions. He was a Board of Governor, Chair of the Education Committee, the Chair of the Region 10 subcommittee and a Distinguished lecturer of the IEEE Electron Device Society. He has also chaired many international conferences and acting as editors for a number of technical journals. In addition, he has received many awards including the UC Regents Fellowship, Golden Keys Scholarship for Academic Excellence, SRC Inventor Recognition Award, Rockwell Research Fellowship, R&D 100 award (for the BSIM3v3 project), Distinguished Teaching Award, the Shenzhen Science and Technology Innovation awards, and EDS Education Award etc. He is a Fellow of HKIE, IET and IEEE.

The Beauty and Limitations of 10 Micron Heterodyne Interferometry (ISI)

NASA Technical Reports Server (NTRS)

Danchi, William C.

2003-01-01

Until recently, heterodyne interferometry at 10 microns has been the only successful technique for stellar interferometry in the very difficult atmospheric window from 9-12 microns. For most of its operational lifetime the U.C. Berkeley Infrared Spatial Interferometer was a single-baseline two telescope (1.65 m aperture) system using CO2 lasers as local oscillators. This instrument was designed and constructed from 1983-1988, and first fringes were obtained at Mt. Wilson in June 1988. During the past few years, a third telescope was constructed and just recently the first closure phases were obtained at 11.15 microns. We discuss the history, physics and technology of heterodyne interferometry in the mid-infrared, and some key astronomical results that have come from this unique instrument.

Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report December 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renae Soelberg

2014-12-01

• PNNL has completed sectioning of the U.C. Berkeley hydride fuel rodlet 1 (highest burn-up) and is currently polishing samples in preparation for optical metallography. • A disk was successfully sectioned from rodlet 1 at the location of the internal thermocouple tip as desired. The transition from annular pellet to solid pellet is verified by the eutectic-filled inner cavity located on the back face of this disk (top left) and the solid front face (bottom left). Preliminary low-resolution images indicate interesting sample characteristics in the eutectic surrounding the rodlet at the location of the outer thermocouple tip (right). This samplemore » has been potted and is currently being polished for high-resolution optical microscopy and subsequent SEM analysis. (See images.)« less

Maneuverability and mobility in palm-sized legged robots

NASA Astrophysics Data System (ADS)

Kohut, Nicholas J.; Birkmeyer, Paul M.; Peterson, Kevin C.; Fearing, Ronald S.

2012-06-01

Palm sized legged robots show promise for military and civilian applications, including exploration of hazardous or difficult to reach places, search and rescue, espionage, and battlefield reconnaissance. However, they also face many technical obstacles, including- but not limited to- actuator performance, weight constraints, processing power, and power density. This paper presents an overview of several robots from the Biomimetic Millisystems Laboratory at UC Berkeley, including the OctoRoACH, a steerable, running legged robot capable of basic navigation and equipped with a camera and active tail; CLASH, a dynamic climbing robot; and BOLT, a hybrid crawling and flying robot. The paper also discusses, and presents some preliminary solutions to, the technical obstacles listed above plus issues such as robustness to unstructured environments, limited sensing and communication bandwidths, and system integration.

Microsoft, libraries and open source

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-04-26

We are finally starting to see the early signs of transformation inscholarly publishing. The innovations we've been expecting for years areslowly being adopted, but we can also expect the pace of change toaccelerate in the coming 3 to 5 years. At the same time, many of ritualsand artifacts of the scholarly communication lifecycle are still rooted ina centuries-old model.  What are the primary goals of scholarlycommunication, and what will be the future role of librarians in thatcycle?  What are the obstacles in information flow (many of our owndesign) that can be removed?Is the library profession moving fast enough to staymore » ahead of the curve...or are we ever going to be struggling to keep up? With the advent of thedata deluge, all-XML workflows, the semantic Web, cloud servicesand increasingly intelligent mobile devices - what are the implicationsfor libraries, archivists, publishers, scholarly societies as well asindividual researchers and scholars? The opportunities are many - butcapitalizing on this ever-evolving landscape will require significantchanges to our field, changes that we are not currently well-positioned toenact. This talk will map the current scholarly communication landscape -highlighting recent exciting developments, and will focus on therepercussions and some specific recommendations for the broader field ofinformation management.About the speaker:Alex Wade is the Director for Scholarly Communication within Microsoft'sExternal Research division, where he oversees several projects related toresearcher productivity tools, semantic information capture, and theinteroperability of information systems. Alex holds a Bachelor's degree inPhilosophy from U.C. Berkeley, and a Masters of Librarianship degree fromthe University of Washington.During his career at Microsoft, Alex has managed the corporate search andtaxonomy management services; has shipped a SharePoint-based document andworkflow management solution for Sarbanes-Oxley compliance; and served asSenior Program Manager for Windows Search in Windows Vista and Windows 7.Prior to joining Microsoft, Alex held Systems Librarian, EngineeringLibrarian, Philosophy Librarian, and technical library positions at theUniversity of Washington, the University of Michigan, and U.C. Berkeley.Web: http://research.microsoft.com/en-us/people/awade/ « less

Final Report. IUT No. B560420 with UC Berkeley. Organic Chemistry at High Pressures &Temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montgomery, W; Crowhurst, J C; Zaug, J M

We have successfully completed the research outlined in our proposal: Organic Chemistry at High Pressures and Temperatures. We have experimentally determined a phase diagram which documents the phases and reaction regimes of cyanuric acid , H{sub 3}C{sub 3}N{sub 3}O{sub 3} (1,3,5-triazine-2,4,6-trione), from 300 - 750 K and 0 - 8.1 GPa. We utilized a comparatively new technique to study thin samples of cyanuric acid in the diamond anvil cell in order to collect ambient temperature, high pressure FTIR and Raman data as well as the high-pressure, high-temperature data used in the phase diagram. These experiments made use of the CMLSmore » High-pressure lab's diamond anvil facilities as well as the FTIR and Raman systems.« less

Search for Terrestrial Planets with SIM Planet Quest

NASA Technical Reports Server (NTRS)

Shao, Michael; Tanner, Angelle M.; Catanzarite, Joseph H.

2006-01-01

SIM is an astrometric mission that will be capable of 1 microarcsec relative astrometric accuracy in a single measurement of approx.1000 sec. The search for terrestrial planets in the habitable zone around nearby stars is one of the main science goals of the project. In 2001, NASA through the peer review process selected 10 key projects, two of which had as its goal, the search for terrestrial planets around nearby stars. The two teams, one led by G. Marcy (UC Berkeley) and one lead by M. Shao (JPL), have an extensive preparatory science program underway. This paper describes the status of this activity as well as the technology status of SIM's narrow angle astrometry capability, to reach 1 uas in a single epoch measure and its ability to average multiple epoch measurements to well below 1 uas.

Single event upset sensitivity of low power Schottky devices

NASA Technical Reports Server (NTRS)

Price, W. E.; Nichols, D. K.; Measel, P. R.; Wahlin, K. L.

1982-01-01

Data taken from tests involving heavy ions in the Berkeley 88 in. cyclotron being directed at low power Schottky barrier devices are reported. The tests also included trials in the Harvard cyclotron with 130 MeV protons, and at the U.C. Davis cyclotron using 56 MeV protons. The experiments were performed to study the single event upsets in MSI logic devices containing flip-flops. Results are presented of single-event upsets (SEU) causing functional degradation observed in post-exposure tests of six different devices. The effectiveness of the particles in producing SEUs in logic device functioning was found to be directly proportional to the proton energy. Shielding was determined to offer negligible protection from the particle bombardment. The results are considered significant for the design and fabrication of LS devices for space applications.

PREFACE: Rusnanotech 2010 International Forum on Nanotechnology

NASA Astrophysics Data System (ADS)

Kazaryan, Konstantin

2011-03-01

The Rusnanotech 2010 International Forum on Nanotechnology was held from November 1-3, 2010, in Moscow, Russia. It was the third forum organized by RUSNANO (Russian Corporation of Nanotechnologies) since 2008. In March 2011 RUSNANO was established as an open joint-stock company through the reorganization of the state corporation Russian Corporation of Nanotechnologies. RUSNANO's mission is to develop the Russian nanotechnology industry through co-investment in nanotechnology projects with substantial economic potential or social benefit. Within the framework of the Forum Science and Technology Program, presentations on key trends of nanotechnology development were given by foreign and Russian scientists, R&D officers of leading international companies, universities and scientific centers. The science and technology program of the Forum was divided into eight sections as follows (by following hyperlinks you may find each section's program including videos of all oral presentations): Catalysis and Chemical Industry Nanobiotechnology Nanodiagnostics Nanoelectronics Nanomaterials Nanophotonics Nanotechnolgy In The Energy Industry Nanotechnology in Medicine The scientific program of the forum included 115 oral presentations by leading scientists from 15 countries. Among them in the "Nanomaterials" section was the lecture by Dr Konstantin Novoselov, winner of the Nobel Prize in Physics 2010. The poster session consisted of over 500 presentations, 300 of which were presented in the framework of the young scientists' nanotechnology papers competition. This volume of the Journal of Physics: Conference Series includes a selection of 57 submissions. The scientific program committee: Prof Zhores Alferov, AcademicianVice-president of Russian Academy of Sciences, Nobel Prize winner, Russia, Chairman of the Program CommitteeProf Sergey Deev, Corresponding Member of Russian Academy of SciencesHead of the Laboratory of Molecular Immunology, M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia, Deputy Chairman of the Program CommitteeProf Alexander Aseev, AcademicianVice-president of Russian Academy of Sciences Director, A V Rzhanov-Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, RussiaProf Sergey Bagaev, AcademicianDirector, Institute of Laser Physics, Siberian Branch of Russian Academy of Sciences, RussiaProf Alexander Gintsburg, Ademician, Russian Academy of Medical SciencesDirector Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, RussiaProf Anatoly Grigoryev, Academician, Russian Academy of Sciences, Russian Academy of Medical SciencesVice-president, Russian Academy of Medical Sciences, RussiaProf Michael Kovalchuk, RAS Corresponding MemberDirector, Kurchatov Institute Russian Scientific Center, RussiaProf Valery Lunin, AcademicianDean, Department of Chemistry, Lomonosov Moscow State University, RussiaProf Valentin Parmon, Academician, DirectorBoreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, RussiaProf Rem Petrov, AcademicianAdvisor, Russian Academy of Sciences, RussiaProf Konstantin Skryabin, AcademicianDirector, Bioinzheneriya Center, Russian Academy of Sciences, RussiaProf Vsevolod Tkachuk, Academician, Russian Academy of Sciences, Russian Academy of Medical SciencesDean, Faculty of Fundamental Medicine, Lomonosov Moscow State University, RussiaProf Vladimir Fortov, AcademicianDirector, Joint Institute for High Temperatures, Russian Academy of Sciences, RussiaProf Alexey Khokhlov, AcademicianVice Principal, Head of Innovation, Information and International Scientific Affairs Department, Lomonosov Moscow State University, RussiaProf Valery Bukhtiyarov, RAS Corresponding MemberDirector, Physicochemical Research Methods Dept., Boreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, RussiaProf Anatoly Dvurechensky, RAS Corresponding MemberDeputy Director, Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, RussiaProf Vladimir Kvardakov, Corresponding Member of Russian Academy of SciencesExecutive Director, Kurchatov Center of Synchrotron Radiation and Nanotechnology, RussiaProf Edward Son, Corresponding member of Russian Academy of SciencesScientific Deputy Director, Joint Institute for High Temperatures, Russian Academy of Sciences, RussiaProf Andrey GudkovSenior Vice President, Basic Science Chairman, Department of Cell Stress Biology, Roswell Park Cancer Institute, USAProf Robert NemanichChair, Department of Physics, Arizona State University, USAProf Kandlikar SatishProfessor, Rochester Institute of Technology, USAProf Xiang ZhangUC Berkeley, Director of NSF Nano-scale Science and Engineering Center (NSEC), USAProf Andrei ZvyaginProfessor, Macquarie University, AustraliaProf Sergey KalyuzhnyDirector of the Scientific and Technological Expertise Department, RUSNANO, RussiaKonstantin Kazaryan, PhDExpert of the Scientific and Technological Expertise Department, RUSNANO, Russia, Program Committee SecretarySimeon ZhavoronkovHead of Nanotechnology Programs Development Office, Rusnanotech Forum Fund for the Nanotechnology Development, Russia Editors of the proceedings: Section "Nanoelectronics" - Corresponding Member of Russian Academy of Sciences, Professor Anatoly Dvurechenskii (Institute of Semiconductor Physics, RAS).Section "Nanophotonics" - Professor Vasily Klimov (Institute of Physics, RAS).Section "Nanodiagnostics" - Professor P Kashkarov (Russian Scientific Center, Kurchatov Institute).Section "Nanotechnology for power engineering" - Corresponding Member of Russian Academy of Sciences, Professor Eduard Son (Joint Institute for High Temperatures, RAS).Section "Catalysis and chemical industry" - Member of Russian Academy of Sciences, Professor Valentin Parmon (Institute of Catalysis SB RAS).Section "Nanomaterials" - E Obraztsova, PhD (Institute of Physics, RAS), Marat Gallamov PhD (Moscow State University).Section "Nanotechnology in medicine" - Denis Logunov, PhD (Gamaleya Research Institute of Epidemiology and Microbiology, RAMS).Section "Nanobiotechnology" - Member of Russian Academy of Sciences, Professor Konstantin Skryabin (Bioengineering Center, RAS), Member of Russian Academy of Sciences, Professor Rem Petrov (RAS), Corresponding Member of Russian Academy of Sciences, Professor Sergey Deev (Institute of Bioorganic Chemistry).

On becoming a nutritional biochemist.

PubMed

McCormick, Donald B

2004-01-01

Much of the science underlying nutrition has come from biochemical studies. This certainly is true in our understanding of the metabolism and function of such micronutrient cofactors as vitamins and metal ions. My own interest stems from an early desire to understand the molecular events in an organism and ultimately to know the fate of those nutrients that are needed to maintain life. My training in chemistry, biochemistry, and nutrition was helpful in gaining knowledge about the interface among these disciplines. My interests followed an understandable trail, beginning with those factors that cause plant galls and continuing through carbohydrate metabolism to vitamins. After all, from studying such pentitols as ribitol with Professor Touster at Vanderbilt University through indoctrination with enzymes, vitamins, and coenzymes with Professor Snell at the University of California-Berkeley, it was rational to begin my independent academic life investigating the enzymes that convert a ribityl-containing vitamin, namely riboflavin, to its operational flavocoenzymes. While at Cornell University, I encountered Professor Wright, who shared an interest in biotin. My realization that there was a similar need to determine the metabolism of lipoate followed logically. Interactions with inorganic chemists such as Professor Sigel at Basel University, as well as inorganic chemists at Cornell, led to an interest in metal ions. As summarized in this article, my colleagues and I are pleased to have contributed to both basic knowledge about cofactors and to have utilized much of this information in extensions to applications. Along the way, I have served by teaching, researching, and administrating at the universities that provided my positions in academe, and I have worked to share the load of numerous public and professional duties that are summarized herein. Altogether it has been an enjoyable career to be a nutritional biochemist. I recommend it for those who follow.

Nuclear Data Needs and Capabilities for Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, D.

2015-05-27

In July 2014, DOE NP carried out a review of the US Nuclear Data Program. This led to several recommendations, including that the USNDP should “devise effective and transparent mechanisms to solicit input and feedback from all stakeholders on nuclear data needs and priorities.” The review also recommended that USNDP pursue experimental activities of relevance to nuclear data; the revised 2014 Mission Statement accordingly states that the USNDP uses “targeted experimental studies” to address gaps in nuclear data. In support of these recommendations, DOE NP requested that USNDP personnel organize a Workshop on Nuclear Data Needs and Capabilities for Applicationsmore » (NDNCA). This Workshop was held at Lawrence Berkeley National Laboratory (LBNL) on 27-29 May 2015. The goal of the NDNCA Workshop was to compile nuclear data needs across a wide spectrum of applied nuclear science, and to provide a summary of associated capabilities (accelerators, reactors, spectrometers, etc.) available for the required measurements. The first two days of the workshop consisted of 25 plenary talks by speakers from 16 different institutions, on nuclear energy (NE), national security (NS), isotope production (IP), and industrial applications (IA). There were also shorter “capabilities” talks that described the experimental facilities and instrumentation available for the measurement of nuclear data. This was followed by a third day of topic-specific “breakout” sessions and a final closeout session. The agenda and copies of these talks are available online at http://bang.berkeley.edu/events/NDNCA/agenda. The importance of nuclear data to both basic and applied nuclear science was reflected in the fact that while the impetus for the workshop arose from the 2014 USNDP review, joint sponsorship for the workshop was provided by the Nuclear Science and Security Consortium, a UC-Berkeley based organization funded by the National Nuclear Security Administration (NNSA).« less

Berkeley Sensor Database, an Implementation of CUAHSI's ODM for the Keck HydroWatch Wireless Sensor Network

NASA Astrophysics Data System (ADS)

Ogle, G.; Bode, C.; Fung, I.

2010-12-01

The Keck HydroWatch Project is a multidisciplinary project devoted to understanding how water interacts with atmosphere, vegetation, soil, and fractured bedrock. It is experimenting with novel techniques to monitor and trace water pathways through these mediums, including developing an intensive wireless sensor network, in the Angelo Coast Range and Sagehen Reserves in California. The sensor time-series data is being supplemented with periodic campaigns experimenting with sampling and tracing techniques, including water chemistry, stable isotope analysis, electrical resistivity tomography (ERT), and neutron probes. Mechanistic and statistical modeling is being performed with these datasets. One goal of the HydroWatch project is to prototype technologies for intensive sampling that can be upscaled to the watershed scale. The Berkeley Sensor Database was designed to manage the large volumes of heterogeneous data coming from this sensor network. This system is based on the Observations Data Model (ODM) developed by the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI). Due to need for the use of open-source software, UC Berkeley ported the ODM to a LAMP system (Linux, Apache, MySQL, Perl). As of August 2010, the Berkeley Sensor Database contains 33 million measurements from 1200 devices, with several thousand new measurements being added each hour. Data for this research is being collected from a wide variety of equipment. Some of this equipment is experimental and subject to constant modification, others are industry standards. Well pressure transducers, sap flow sensors, experimental microclimate motes, standard weather stations, and multiple rock and soil moisture sensors are some examples. While the Hydrologic Information System (HIS) and the ODM are optimized for data interoperability, they are not focused on facility management and data quality control which occur at a complex research site. In this presentation, we describe our implementation of the ODM, the modifications we made to the ODM schema to include incident reports, concepts of 'stations', reuse and moving of equipment, and NASA data quality levels. The HydroWatch researchers' data use vary radically, so we implemented a number of different accessors to the data, from real-time graphing during storms to direct SQL queries for automated analysis to full data dumps for heavy statistical modeling.

Boron Nitride Nanotube: Synthesis and Applications

NASA Technical Reports Server (NTRS)

Tiano, Amanda L.; Park, Cheol; Lee, Joseph W.; Luong, Hoa H.; Gibbons, Luke J.; Chu, Sang-Hyon; Applin, Samantha I.; Gnoffo, Peter; Lowther, Sharon; Kim, Hyun Jung;

Connecting Scientists, College Students, Middle School Students & Elementary Students through Intergenerational Afterschool STEM Programming

NASA Astrophysics Data System (ADS)

Ali, N. A.; Paglierani, R.; Raftery, C. L.; Romero, V.; Harper, M. R.; Chilcott, C.; Peticolas, L. M.; Hauck, K.; Yan, D.; Ruderman, I.; Frappier, R.

2015-12-01

The Multiverse education group at UC Berkeley's Space Sciences Lab created the NASA-funded "Five Stars Pathway" model in which five "generations" of girls and women engage in science together in an afterschool setting, with each generation representing one stage in the pathway of pursuing a career in science, technology, engineering, or math (STEM). The five stages are: elementary-age students, middle-school-age students, undergraduate-level college students, graduate-level college students and professional scientists. This model was field-tested at two Girls Inc. afterschool locations in the San Francisco Bay Area and distributed to Girls Inc. affiliates and other afterschool program coordinators nationwide. This presentation will explore some of the challenges and success of implementing a multigenerational STEM model as well as distributing the free curriculum for interested scientists and college students to use with afterschool programs.

Application of the Molecular Adsorber Coating Technology on the Ionospheric Connection Explorer Program

NASA Technical Reports Server (NTRS)

Abraham, Nithin S.; Hasegawa, Mark M.; Secunda, Mark S.

2016-01-01

The Molecular Adsorber Coating (MAC) is a zeolite based highly porous coating technology that was developed by NASA Goddard Space Flight Center (GSFC) to capture outgassed contaminants, such as plastics, adhesives, lubricants, silicones, epoxies, potting compounds, and other similar materials. This paper describes the use of the MAC technology to address molecular contamination concerns on NASAs Ionospheric Connection Explorer (ICON) program led by the University of California (UC) Berkeleys Space Sciences Laboratory. The sprayable paint technology was applied onto plates that were installed within the instrument cavity of ICONs Far Ultraviolet Imaging Spectrograph (FUV). However, due to the instruments particulate sensitivity, the coating surface was vibrationally cleaned through simulated acoustics to reduce the risk of particle fall-out contamination. This paper summarizes the coating application efforts on the FUV adsorber plates, the simulated laboratory acoustic level cleaning test methods, particulation characteristics, and future plans for the MAC technology.

Application of the Molecular Adsorber Coating technology on the Ionospheric Connection Explorer program

NASA Astrophysics Data System (ADS)

Abraham, Nithin S.; Hasegawa, Mark M.; Secunda, Mark S.

2016-09-01

The Molecular Adsorber Coating (MAC) is a zeolite based highly porous coating technology that was developed by NASA Goddard Space Flight Center (GSFC) to capture outgassed contaminants, such as plastics, adhesives, lubricants, silicones, epoxies, potting compounds, and other similar materials. This paper describes the use of the MAC technology to address molecular contamination concerns on NASA's Ionospheric Connection Explorer (ICON) program led by the University of California (UC) Berkeley's Space Sciences Laboratory. The sprayable paint technology was applied onto plates that were installed within the instrument cavity of ICON's Far Ultraviolet Imaging Spectrograph (FUV). However, due to the instrument's particulate sensitivity, the coating surface was vibrationally cleaned through simulated acoustics to reduce the risk of particle fall-out contamination. This paper summarizes the coating application efforts on the FUV adsorber plates, the simulated laboratory acoustic level cleaning test methods, particulation characteristics, and future plans for the MAC technology.

Probing quantumness with joint continuous measurements of non-commuting qubit observables

NASA Astrophysics Data System (ADS)

Garcia-Pintos, Luis Pedro; Dressel, Justin

In this talk we consider continuous weak measurements as a means to probe foundational issues in quantum mechanics. We consider the simultaneous monitoring of two noncommuting observables-as recently implemented by the Siddiqi group at UC Berkeley. Contrary to naive expectation, the output of such experiment can be used to simultaneously track the approximate observable dynamics. Despite this seeming realism, we also show that the readouts violate macrorealistic Leggett-Garg inequalities for arbitrarily short temporal correlations, and that the derived inequalities are manifestly violated even in the absence of Hamiltonian evolution. Such violations should indicate the failure of at least one postulate of macrorealism: either physical quantities do not have well defined values at all times, or the measurement process itself disturbs what is being measured. Despite this macrorealism violation, we construct a realistic, but epistemically restricted, model that perfectly emulates both the qubit evolution and the observed noisy signals, thus also emulating the violations.

Boron nitride nanotube: synthesis and applications

NASA Astrophysics Data System (ADS)

Tiano, Amanda L.; Park, Cheol; Lee, Joseph W.; Luong, Hoa H.; Gibbons, Luke J.; Chu, Sang-Hyon; Applin, Samantha; Gnoffo, Peter; Lowther, Sharon; Kim, Hyun Jung; Danehy, Paul M.; Inman, Jennifer A.; Jones, Stephen B.; Kang, Jin Ho; Sauti, Godfrey; Thibeault, Sheila A.; Yamakov, Vesselin; Wise, Kristopher E.; Su, Ji; Fay, Catharine C.

2014-04-01

Scientists have predicted that carbon's immediate neighbors on the periodic chart, boron and nitrogen, may also form perfect nanotubes, since the advent of carbon nanotubes (CNTs) in 1991. First proposed then synthesized by researchers at UC Berkeley in the mid 1990's, the boron nitride nanotube (BNNT) has proven very difficult to make until now. Herein we provide an update on a catalyst-free method for synthesizing highly crystalline, small diameter BNNTs with a high aspect ratio using a high power laser under a high pressure and high temperature environment first discovered jointly by NASA/NIA/JSA. Progress in purification methods, dispersion studies, BNNT mat and composite formation, and modeling and diagnostics will also be presented. The white BNNTs offer extraordinary properties including neutron radiation shielding, piezoelectricity, thermal oxidative stability (> 800°C in air), mechanical strength, and toughness. The characteristics of the novel BNNTs and BNNT polymer composites and their potential applications are discussed.

Remote sensing research for agricultural applications. [San Joaquin County, California and Snake River Plain and Twin Falls area, Idaho

NASA Technical Reports Server (NTRS)

Colwell, R. N. (Principal Investigator); Wall, S. L.; Beck, L. H.; Degloria, S. D.; Ritter, P. R.; Thomas, R. W.; Travlos, A. J.; Fakhoury, E.

1984-01-01

Materials and methods used to characterize selected soil properties and agricultural crops in San Joaquin County, California are described. Results show that: (1) the location and widths of TM bands are suitable for detecting differences in selected soil properties; (2) the number of TM spectral bands allows the quantification of soil spectral curve form and magnitude; and (3) the spatial and geometric quality of TM data allows for the discrimination and quantification of within field variability of soil properties. The design of the LANDSAT based multiple crop acreage estimation experiment for the Idaho Department of Water Resources is described including the use of U.C. Berkeley's Survey Modeling Planning Model. Progress made on Peditor software development on MIDAS, and cooperative computing using local and remote systems is reported as well as development of MIDAS microcomputer systems.

Simulations of carbon fiber composite delamination tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kay, G

2007-10-25

Simulations of mode I interlaminar fracture toughness tests of a carbon-reinforced composite material (BMS 8-212) were conducted with LSDYNA. The fracture toughness tests were performed by U.C. Berkeley. The simulations were performed to investigate the validity and practicality of employing decohesive elements to represent interlaminar bond failures that are prevalent in carbon-fiber composite structure penetration events. The simulations employed a decohesive element formulation that was verified on a simple two element model before being employed to perform the full model simulations. Care was required during the simulations to ensure that the explicit time integration of LSDYNA duplicate the near steady-statemore » testing conditions. In general, this study validated the use of employing decohesive elements to represent the interlaminar bond failures seen in carbon-fiber composite structures, but the practicality of employing the elements to represent the bond failures seen in carbon-fiber composite structures during penetration events was not established.« less

Materials for Better Li-based Storage Systems for a "Green Energy Society"

ScienceCinema

Jean-Marie Tarascon

2017-12-09

Li-ion batteries are strongly considered for powering the upcoming generations of HEVs and PHEVs, but there are still the issues of safety and costs in terms of materials resources and abundances, synthesis, and recycling processes. Notions of materials having minimum footprint in nature, made via eco-efficient processes, must be integrated in our new research towards the next generation of sustainable and "greener" Li-ion batteries. In this July 13, 2009 talk sponsored by Berkeley Lab's Environental Energy Technologies Division, Jean-Marie Tarascon, a professor at the University of Picardie (Amiens), discuss Eco-efficient synthesis via hydrothermal/solvothermal processes using latent bases as well as structure directing templates or other bio-related approaches of LiFePO4 nanopowders.

Townes Group Activities from 1983-2000: Personal Recollections of William Danchi

NASA Technical Reports Server (NTRS)

Danchi, William C.

2015-01-01

I arrived in Berkeley in October 1983 as a post-doc, and my appointment was at the Space Sciences Laboratory (SSL). During that time the group was very large, with multiple activities led by Charlie himself and also by Senior Fellows such as John Lacy, Dan Jaffe, and Al Betz at the top of the hill at Space Sciences. Another significant contingent of the Townes group was housed in Birge Hall on campus, led by Reinhard Genzel when he was an Assistant Professor in the Physics Department. Although the group encompassed two separate locations, it functioned as one large group. Either we rode with Charlie up and down the hill, or (if we were concerned about our safety!) we took the bus.

Closet to Cloud: The online archiving of tape-based continuous NCSN seismic data from 1993-2005

NASA Astrophysics Data System (ADS)

Neuhauser, D. S.; Aranha, M. A.; Kohler, W. M.; Oppenheimer, D.

2016-12-01

As earthquake monitoring systems in the 1980s moved from analog to digital recording systems, most seismic networks only archived digital waveforms from detected events due to lack of affordable online digital storage for continuous high-rate (100 sps) data. The Northern California Earthquake Data Center (NCEDC), established in 1991 by UC Berkeley and the USGS Menlo Park, archived 20 sps continuous data and triggerd high-rate from the sparse Berkeley seismic network, but could not afford the online storage for continuous high-rate data from the 300+ stations of the USGS Northern California Seismic Network (NCSN). The discovery of non-volcanic tremor and the use of continuous waveform correlation techniques for detecting repeating earthquakes combined with the increase in disk capacity capacity and significant reduction in disk costs led the Northern California Earthquake Data Center (NCEDC) to begin archiving continuous high-rate waveforms in 2004-2005. The USGS Menlo Park NCSN network had backup tapes of continuous high-rate waveform data since 1993 on the shelf, and the USGS and NCEDC embarked on a project to restore and archive all continuous NCSN data from 1993 through 2005. We will discuss the procedures and problems encountered when reading, transcribing, converting data formats, SEED channel naming, and archiving the 1993-2005 continuous NCSN waveforms. We will also illustrate new science enabled by these data. These and other northern California seismic and geophysical data are available via web services at http://service.ncedc.org

Radio Frequency Plasma Synthesis of Boron Nitride Nanotubes (BNNTs) for Structural Applications. Part II

NASA Technical Reports Server (NTRS)

Hales, Stephen J.; Alexa, Joel A.; Jensen, Brian J.

2016-01-01

Boron nitride nanotubes (BNNTs) are more thermally and chemically compatible with metal- and ceramic-matrix composites than carbon nanotubes (CNTs). The lack of an abundant supply of defect-free, high-aspect-ratio BNNTs has hindered development as reinforcing agents in structural materials. Recent activities at the National Research Council - Canada (NRC-C) and the University of California - Berkeley (UC-B) have resulted in bulk synthesis of few-walled, small diameter BNNTs. Both processes employ induction plasma technology to create boron vapor and highly reactive nitrogen species at temperatures in excess of 8000 K. Subsequent recombination under controlled cooling conditions results in the formation of BNNTs at a rate of 20 g/hr and 35 g/hr, respectively. The end product tends to consist of tangled masses of fibril-, sheet-, and cotton candy-like materials, which accumulate within the processing equipment. The radio frequency plasma spray (RFPS) facility at NASA Langley (LaRC), developed for metallic materials deposition, has been re-tooled for in-situ synthesis of BNNTs. The NRC-C and UC-B facilities comprise a 60 kW RF torch, a reactor with a stove pipe geometry, and a filtration system. In contrast, the LaRC facility has a 100 kW torch mounted atop an expansive reaction chamber coupled with a cyclone separator. The intent is to take advantage of both the extra power and the equipment configuration to simultaneously produce and gather BNNTs in a macroscopic form amenable to structural material applications.

Enhancing climate literacy through the use of an interdisciplinary global change framework and conceptual models

NASA Astrophysics Data System (ADS)

Bean, J. R.; Zoehfeld, K.; Mitchell, K.; Levine, J.; White, L. D.

2016-12-01

Understanding climate change and how to mitigate the causes and consequences of anthropogenic activities are essential components of the Next Generations Science Standards. To comprehend climate change today and why current rates and magnitudes of change are of concern, students must understand the various factors that drive Earth system processes and also how they interrelate. The Understanding Global Change web resource in development from the UC Museum of Paleontology will provide science educators with a conceptual framework, graphical models, lessons, and assessment templates for teaching NGSS aligned, interdisciplinary, climate change curricula. To facilitate students learning about the Earth as a dynamic, interacting system of ongoing processes, the Understanding Global Change site will provide explicit conceptual links for the causes of climate change (e.g., burning of fossil fuels, deforestation), Earth system processes (e.g., Earth's energy budget, water cycle), and the changes scientists measure in the Earth system (e.g., temperature, precipitation). The conceptual links among topics will be presented in a series of storyboards that visually represent relationships and feedbacks among components of the Earth system and will provide teachers with guides for implementing NGSS-aligned climate change instruction that addresses physical science, life sciences, Earth and space science, and engineering performance expectations. These visualization and instructional methods are used by teachers during professional development programs at UC Berkeley and the Smithsonian National Museum of Natural History and are being tested in San Francisco Bay Area classrooms.

On the Suitability of Lanthanides as Actinide Analogs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szigethy, Geza; Raymond, Kenneth N.

2008-04-11

With the current level of actinide materials used in civilian power generation and the need for safe and efficient methods for the chemical separation of these species from their daughter products and for long-term storage requirements, a detailed understanding of actinide chemistry is of great importance. Due to the unique bonding properties of the f-elements, the lanthanides are commonly used as structural and chemical models for the actinides, but differences in the bonding between these 4f and 5f elements has become a question of immediate applicability to separations technology. This brief overview of actinide coordination chemistry in the Raymond groupmore » at UC Berkeley/LBNL examines the validity of using lanthanide analogs as structural models for the actinides, with particular attention paid to single crystal X-ray diffraction structures. Although lanthanides are commonly accepted as reasonable analogs for the actinides, these comparisons suggest the careful study of actinide materials independent of their lanthanide analogs to be of utmost importance to present and future efforts in nuclear industries.« less

Teaching and Learning with a NASA-Sponsored GEMS Space Science Curriculum: Using Research and Evaluation Results to Inform and Guide EPO Professionals, an Interactive Panel Session

NASA Astrophysics Data System (ADS)

Schultz, G.; Granger, E.; Catz, K. N.; Wierman, T.

2010-08-01

The newly-developed Space Science Sequence (SSS) is the product of a collaboration between NASA forums/missions and the Lawrence Hall of Science (LHS) Great Explorations in Math and Science (GEMS) program, based at UC Berkeley. At the ASP 2007 conference, keynote speaker George (Pinky) Nelson made special mention of partners involved and the curriculum produced. From the proceedings: "I want to recognize Jacqueline Barber, Isabel Hawkins, Greg Schultz and their colleagues. . . for setting an example of effective partnershipldots We would do well to become familiar with [the SSS] and promote them to teachers and schoolsldots At the same time, we can learn from teachers and students using [the SSS]\\. . . " (2008; p. 3). It is specifically such professional learning, from practicing teachers and grade school students, which motivated this panel session focusing on research and evaluation studies on teacher and student gains using the Space Science Sequence for Grades 3-5.

First Light with the NRAO Transient Event Capture Hardware

NASA Astrophysics Data System (ADS)

Langston, Glen; Rumberg, B.; Brandt, P.

2007-12-01

The design, implementation and testing of the first NRAO Event Capture data acquisition system is presented. The NRAO in Green Bank is developing a set of new data acquisition systems based on the U.C. Berkeley CASPER IBOB/ADC/BEE2 hardware. We describe the hardware configuration and initial experiences with the development system. We present first astronomical tests of the Event Capture system, using the 43m telescope (140ft). These observations were carried out at 900 MHz. The observations were made on 2007 July 8 and 9 towards the Crab pulsar, the galactic center, the Moon and two test observations while the 43m was pointed at Zenith (straight up). The Event Capture is one of several on-going FPGA based data acquisition projects being implemented for the Robert C. Byrd Green Bank Telescope (GBT) and for the 43m telescopes. The NRAO Configurable Instrument Collaboration for Agile Data Acquisition (CICADA) program is described at: http://wikio.nrao.edu/bin/view/CICADA

Real-Time Visualization Tool Integrating STEREO, ACE, SOHO and the SDO

NASA Astrophysics Data System (ADS)

Schroeder, P. C.; Luhmann, J. G.; Marchant, W.

2011-12-01

The STEREO/IMPACT team has developed a new web-based visualization tool for near real-time data from the STEREO instruments, ACE and SOHO as well as relevant models of solar activity. This site integrates images, solar energetic particle, solar wind plasma and magnetic field measurements in an intuitive way using near real-time products from NOAA and other sources to give an overview of recent space weather events. This site enhances the browse tools already available at UC Berkeley, UCLA and Caltech which allow users to visualize similar data from the start of the STEREO mission. Our new near real-time tool utilizes publicly available real-time data products from a number of missions and instruments, including SOHO LASCO C2 images from the SOHO team's NASA site, SDO AIA images from the SDO team's NASA site, STEREO IMPACT SEP data plots and ACE EPAM data plots from the NOAA Space Weather Prediction Center and STEREO spacecraft positions from the STEREO Science Center.

The ASSURE Summer REU Program: Introducing research to first-generation and underserved undergraduates through space sciences and engineering projects

NASA Astrophysics Data System (ADS)

Barron, Darcy; Peticolas, Laura; Multiverse Team at UC Berkeley's Space Sciences Lab

2018-01-01

The Advancing Space Science through Undergraduate Research Experience (ASSURE) summer REU program is an NSF-funded REU site at the Space Sciences Lab at UC Berkeley that first started in summer 2014. The program recruits students from all STEM majors, targeting underserved students including community college students and first-generation college students. The students have little or no research experience and a wide variety of academic backgrounds, but have a shared passion for space sciences and astronomy. We will describe our program's structure and the components we have found successful in preparing and supporting both the students and their research advisors for their summer research projects. This includes an intensive first week of introductory lectures and tutorials at the start of the program, preparing students for working in an academic research environment. The program also employs a multi-tiered mentoring system, with layers of support for the undergraduate student cohort, as well as graduate student and postdoctoral research advisors.

The Global Systems Science High School Curriculum

NASA Astrophysics Data System (ADS)

Gould, A. D.; Sneider, C.; Farmer, E.; Erickson, J.

2015-12-01

Global Systems Science (GSS), a high school integrated interdisciplinary science project based at Lawrence Hall of Science at UC Berkeley, began in the early 1990s as a single book "Planet at Risk" which was only about climate change. Federal grants enabled the project to enlist about 150 teachers to field test materials in their classes and then meeting in summer institutes to share results and effect changes. The result was a series of smaller modules dealing not only with climate change, but other related topics including energy flow, energy use, ozone, loss of biodiversity, and ecosystem change. Other relevant societal issues have also been incorporated including economics, psychology and sociology. The course has many investigations/activities for student to pursue, interviews with scientists working in specific areas of research, and historical contexts. The interconnectedness of a myriad of small and large systems became an overarching theme of the resulting course materials which are now available to teachers for free online at http://www.globalsystemsscience.org/

Promoting job safety for workers with intellectual disabilities: the staying safe at work training curriculum.

PubMed

Dewey, Robin

2011-01-01

In the United States, approximately 125,000 people with disabilities are employed through Community Rehabilitation Programs in manufacturing, assembly, and service jobs. These jobs have significant hazards and, consequently, the workers are at risk of injury. Training that empowers workers to participate in prevention efforts can help reduce work-related injuries. In general this kind of health and safety training in the United States is limited. It is even more so for workers with intellectual disabilities, in part because there have not been programs for teaching individuals with cognitive challenges health and safety skills, adapted to their learning needs. This paper describes the development and promotion of the Staying Safe at Work curriculum of UC Berkeley's Labor Occupational Health Program, which is designed for use by support agencies and employers of workers with intellectual disabilities. The goal of this program is to teach these workers essential occupational safety and health skills in a manner they can understand.

Project Final Report: The Institute for Sustained Performance, Energy, and Resilience (SUPER)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hollingsworth, Jeffrey K.

This project concentrated on various aspects of creating and applying tool infrastructure to make it easier to effectively use large-scale parallel computers. This project was collaborative with Argonne National Laboratory, Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, Oak Ridge National Laboratory, U.C. San Diego, University of Maryland, University of North Carolina, University of Oregon, University Southern California, University of Tennessee, and University of Utah. The research conducted during this project at the University of Maryland is summarized in this report. The complete details of the work are available in the publications listed at the end of the report. Manymore » of the concepts created during this project have been incorporated into tools and made available as freely downloadable software (www.dyninst.org/harmony). It also supported the studies of six graduate students, one undergraduate student, and two post-docs. The funding also provided summer support for the PI and part of the salary of a research staff member.« less

Scalable File Systems for High Performance Computing Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, S A

2007-10-03

Simulations of mode I interlaminar fracture toughness tests of a carbon-reinforced composite material (BMS 8-212) were conducted with LSDYNA. The fracture toughness tests were performed by U.C. Berkeley. The simulations were performed to investigate the validity and practicality of employing decohesive elements to represent interlaminar bond failures that are prevalent in carbon-fiber composite structure penetration events. The simulations employed a decohesive element formulation that was verified on a simple two element model before being employed to perform the full model simulations. Care was required during the simulations to ensure that the explicit time integration of LSDYNA duplicate the near steady-statemore » testing conditions. In general, this study validated the use of employing decohesive elements to represent the interlaminar bond failures seen in carbon-fiber composite structures, but the practicality of employing the elements to represent the bond failures seen in carbon-fiber composite structures during penetration events was not established.« less

High-Flux Neutron Generator Facility for Geochronology and Nuclear Physics Research

NASA Astrophysics Data System (ADS)

Waltz, Cory; HFNG Collaboration

2015-04-01

A facility based on a next-generation, high-flux D-D neutron generator (HFNG) is being commissioned at UC Berkeley. The generator is designed to produce monoenergetic 2.45 MeV neutrons at outputs exceeding 1011 n/s. The HFNG is designed around two RF-driven multi-cusp ion sources that straddle a titanium-coated copper target. D + ions, accelerated up to 150 keV from the ion sources, self-load the target and drive neutron generation through the d(d,n)3 He fusion reaction. A well-integrated cooling system is capable of handling beam power reaching 120 kW impinging on the target. The unique design of the HFNG target permits experimental samples to be placed inside the target volume, allowing the samples to receive the highest neutron flux (1011 cm-2 s-1) possible from the generator. In addition, external beams of neutrons will be available simultaneously, ranging from thermal to 2.45 MeV. Achieving the highest neutron yields required carefully designed schemes to mitigate back-streaming of high energy electrons liberated from the cathode target by deuteron bombardment. The proposed science program is focused on pioneering advances in the 40 Ar/39 Ar dating technique for geochronology, new nuclear data measurements, basic nuclear science, and education. An end goal is to become a user facility for researchers. This work is supported by NSF Grant No. EAR-0960138, U.S. DOE LBNL Contract No. DE-AC02-05CH11231, U.S. DOE LLNL Contract No. DE-AC52-07NA27344, and UC Office of the President Award 12-LR-238745.

Design, Analysis, Hybrid Testing and Orientation Control of a Floating Platform with Counter-Rotating Vertical-Axis Wind Turbines

NASA Astrophysics Data System (ADS)

Kanner, Samuel Adam Chinman

The design and operation of two counter-rotating vertical-axis wind turbines on a floating, semi-submersible platform is studied. The technology, called the Multiple Integrated and Synchronized Turbines (MIST) platform has the potential to reduce the cost of offshore wind energy per unit of installed capacity. Attached to the platform are closely-spaced, counter-rotating turbines, which can achieve a higher power density per planform area because of synergistic interaction effects. The purpose of the research is to control the orientation of the platform and rotational speeds of the turbines by modifying the energy absorbed by each of the generators of the turbines. To analyze the various aspects of the platform and wind turbines, the analysis is drawn from the fields of hydrodynamics, electromagnetics, aerodynamics and control theory. To study the hydrodynamics of the floating platform in incident monochromatic waves, potential theory is utilized, taking into account the slow-drift yaw motion of the platform. Steady, second-order moments that are spatially dependent (i.e., dependent on the platform's yaw orientation relative to the incident waves) are given special attention since there are no natural restoring yaw moment. The aerodynamics of the counter-rotating turbines are studied in collaboration with researchers at the UC Berkeley Mathematics Department using a high-order, implicit, large-eddy simulation. An element flipping technique is utilized to extend the method to a domain with counter-rotating turbines and the effects from the closely-spaced turbines is compared with existing experimental data. Hybrid testing techniques on a model platform are utilized to prove the controllability of the platform in lieu of a wind-wave tank. A 1:82 model-scale floating platform is fabricated and tested at the UC Berkeley Physical-Model Testing Facility. The vertical-axis wind turbines are simulated by spinning, controllable actuators that can be updated in real-time of the model scale. Under certain wind and wave headings, it is possible to control the orientation of the platform in regular waves to maximize the power output from the turbines. A time-domain numerical simulation tool is able to confirm some of the experimental findings, taking into account the decoupled properties of the slow-drift hydrodynamics and wind turbine aerodynamics. Future platform designs are discussed, including the French-based, pre-commercial design from Nenuphar Wind, called the TwinFloat, which is closely related to concepts examined in the thesis.

76 FR 37650 - Safety Zone; 4th of July Festival Berkeley Marina Fireworks Display Berkeley, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

...-AA00 Safety Zone; 4th of July Festival Berkeley Marina Fireworks Display Berkeley, CA AGENCY: Coast... the 4th of July Festival Berkeley Marina Fireworks Display. Unauthorized persons or vessels are... display. Background and Purpose The City of Berkeley Marina will sponsor the 4th of July Festival Berkeley...

Reflection Grating Array Associated with the Reflection Grating Spectrometer Developed by the Space Research Organization of the Netherlands for the X-ray Multi-Mirror Mission (XMM)

NASA Technical Reports Server (NTRS)

Kahn, Steven M.

2001-01-01

The University of California, Berkeley (UCB) served as the Principal Investigator institution for the United States participation in the development of the Reflection Grating Spectrometer (RGS) which included the design, development, fabrication, and testing of the Reflection Grating Assembly (RGA). UCB was assisted in this role by the Lawrence Livermore National Laboratory and Columbia University who provided the primary facilities, materials, services and personnel necessary to complete the development. UC Berkeley's Dr. Steven Kahn provided the technical and scientific oversight for the design. development and testing of the RGA units by monitoring the performance of the units at various stages in their development. Dr. Kahn was also the primary contact with the Space Research Organization of the Netherlands (SRON) and represented the RGA development at all SRON and European Space Agency (ESA) reviews of the RGA status. In accordance with the contract, the team designed and developed novel optical technology to meet the unique requirements of the RGS. The ESA XMM-Newton Mission carries two identical Reflection Grating Spectrometers (RGS) behind two of its three nested sets of Wolter I type mirrors. The instrument allows high-resolution measurements in the soft X-ray range (6 to 38 angstroms or 2.1 to 0.3 keV) with a maximum effective area of about 140 sq cm at 15 angstroms. Its design is optimized for the detection of the K-shell transitions of carbon, nitrogen, oxygen, neon, magnesium, and silicon. as well as the L shell transitions of iron. The RGA itself consists of two units. A structure for each unit was designed to hold up to 220 gratings. In its final configuration, one unit holds 182 gratings and the second hold 181 gratings.

NASA Design Projects at UC Berkeley for NASA's HEDS-UP Program

NASA Astrophysics Data System (ADS)

Kuznetz, Lawrence

1998-01-01

Missions to Mars have been a topic for study since the advent of the space age. But funding has been largely reserved for the unmanned probes such as Viking, Pathfinder and Global Surveyer. Financial and political constraints have relegated human missions, on the other hand, to backroom efforts such as the Space Exploration Initiative (SEI) of 1989-1990. With the new found enthusiasm from Pathfinder and the meteorite ALH84001, however, there is renewed interest in human exploration of Mars. This is manifest in the new Human Exploration and Development of Space (HEDS) program that NASA has recently initiated. This program, through its University Projects (HEDS-UP) office has taken the unusual step of soliciting creative solutions from universities. For its part in the HEDS-UP program, the University of California at Berkeley was asked to study the issues of Habitat design, Space Suits for Mars, Environmental Control and Life Support Systems, Countermeasures to Hypogravity and Crew Size/Mix. These topics were investigated as design projects in "Mars by 2012", an on-going class for undergraduates and graduate students. The methodology of study was deemed to be as important as the design projects themselves and for that we were asked to create an Interactive Design Environment. The Interactive Design Environment (IDE) is an electronic "office" that allows scientists and engineers, as well as other interested parties, to interact with and critique engineering designs as they progress. It usually takes the form of a website that creates a "virtual office" environment. That environment is a place where NASA and others can interact with and critique the university designs for potential inclusion in the Mars Design Reference Mission.

How can the curation of hands-on STEM activities power successful mobile apps and websites?

NASA Astrophysics Data System (ADS)

Porcello, D.; Peticolas, L. M.; Schwerin, T. G.

2015-12-01

The Lawrence Hall of Science (LHS) is University of California, Berkeley's public science center. Over the last decade, the Center for Technology Innovation at LHS has partnered with many institutions to establish a strong track record of developing successful technology solutions to support STEM teaching and learning within informal environments. Curation by subject-matter experts has been at the heart of many educational technology products from LHS and its partners that are directed at educators and families. This work includes: (1) popular digital libraries for inquiry-based activities at Howtosmile.org (NSF DRL #0735007) and NASA Earth and Space science education resources at NASAwavelength.org; and novel mobile apps like DIY Sun Science (NASA NNX10AE05G) and DIY Human Body (NIH 5R25OD010543) designed to scaffold exploration of STEM phenomena at home. Both NASA Wavelength and DIY Sun Science arose out of long-term collaborations with the Space Sciences Laboratory at UC Berkeley, Institute for Global Environmental Strategies (IGES), and other NASA-funded organizations, in partnership with NASA through cooperative agreements. This session will review the development, formative evaluation, and usage metrics for these two Earth and Space science-themed educational technology products directly relevant to the AGU community. Questions reviewed by presenters will include: What makes a good hands-on activity, and what essential information do educators depend on when searching for programming additions? What content and connections do families need to explore hands-on activities? How can technology help incorporate educational standards into the discovery process for learning experiences online? How do all these components drive the design and user experience of websites and apps that showcase STEM content?

Legitimizing Security in the Ivory Tower: Canadian University Corporate Security Services' Public Quest for Legitimacy.

PubMed

Wilkinson, Blair

2016-05-01

This article examines how university corporate security (UCS) services engage in legitimation work in their attempts to make their university communities (i.e., faculty, staff, students) and political masters (i.e., university administrators, boards of governors, senators) believe that they are honest, trustworthy, and caring and have authority that should be deferred to. This is accomplished through the analysis of interview and observational data collected as part of a research project exploring UCS services at five Canadian universities and an examination of how UCS services at 14 Canadian universities communicate using the social media service Twitter. These UCS services were found to primarily use Twitter for the purposes of soliciting or requesting information and for networking. In communicating through Twitter, UCS services engage in public legitimation work in which they make claims about and attempt to demonstrate their expertise, authority, and accountability. This article argues that both UCS services' particular legitimacy problem (i.e., their possession of both private and public attributes) and the interactive nature of public legitimation work create tensions that may serve to disrupt UCS services' ability to attain legitimacy. Cet article examine la manière dont les services de sécurité d'entreprise à l'université (SEU) s'engagent à légitimer leurs tentatives de persuader leurs communautés universitaires (c'est-à-dire le corps professoral, le personnel et les étudiants) ainsi que la haute administration (c'est-à-dire les administrateurs de l'université, le conseil des gouverneurs et les sénateurs) qu'ils sont honnêtes, attentifs, dignes de confiance, et qu'ils possèdent un niveau d'autorité auquel quiconque devrait se référer. Ceci sera accompli en analysant un corpus d'entrevues et d'observations dans le cadre d'un projet de recherche examinant les services de type SEU dans cinq universités canadiennes, ainsi qu'une étude sur la manière dont les services de SEU dans quatorze universités canadiennes gèrent leurs communications sur le réseau de médias sociaux Twitter. Il a été établi que ces services de SEU utilisent principalement Twitter pour la sollicitation ou la demande d'informations, et pour le réseautage. En communiquant par Twitter, les services de SEU s'engagent dans un processus de légitimation par lequel ils revendiquent et tentent de démontrer leur expertise, autorité, transparence et responsabilité. Cet article propose l'argument suivant: la question de la légitimité particulière des services de SEU (c'est-à-dire leur possession d'attributs à la fois privés et publics) combinée avec la nature interactive du processus de légitimation publique crée des tensions qui peuvent en fin de compte perturber la capacité des services de SEU à atteindre réellement cette légitimité. © 2016 Canadian Sociological Association/La Société canadienne de sociologie.

Astrobiological Studies Plan at UCSD and the University of Buckingham

NASA Astrophysics Data System (ADS)

Gibson, Carl H.; Wickramasinghe, N. Chandra

2011-10-01

A UC-HBCU grant is requested to assist undergraduate and masters level HBCU Interns to achieve their professional and academic goals by attending summer school classes at UCSD along with graduate students in the UCSD Astrobiology Studies program, and by also attending a NASA sponsored scientific meeting in San Diego on Astrobiology organized by NASA scientist Richard Hoover (the 14th in a sequence). Hoover has recently published a paper in the Journal of Cosmology claiming extraterrestrial life fossils in three meteorites. Students will attend a workshop to prepare research publications on Astrobiological Science for the Journal of Cosmology or equivalent refereed journal, mentored by UCSD faculty and graduate students as co-authors and referees, all committed to the several months of communication usually required to complete a publishable paper. The program is intended to provide pathways to graduate admissions in the broad range of science and engineering fields, and by exposure to fundamental science and engineering disciplines needed by Astrobiologists. A three year UC-HBCU Astrobiological Studies program is proposed: 2011, 2012 and 2013. Interns would be eligible to enter this program when they become advanced graduate students. A center of excellence in astrobiology is planned for UCSD similar to that Directed by Professor Wickramasinghe for many years with Fred Hoyle at Cardiff University, http://www.astrobiology.cf.ac.uk /chandra1.html. Professor Wickramasinghe's CV is attached as Appendix 1. Figures A2-1,2 of Appendix 2 compare Astrobiology timelines of modern fluid mechanical and astrobiological models of Gibson/Wickramasinghe/Schild of the Journal of Cosmology with standard NASA- CDMHC models. NASA support will be sought to support research and educational aspects of both initiatives. Overload teaching of up to two courses a year by UCSD faculty of key astrobiology courses at either UCSD or at HBCU campuses is authorized by recent guidelines of UCSD Senior Vice Chancellor Subramani for Academic Affairs, following recommendations of Dean Seible of the UCSD Jacobs School of Engineering. Appendix 3 summarizes how this proposal will meet the goals of the UCOP initiatives.

77 FR 37604 - Safety Zone; Fourth of July Fireworks, Berkeley Marina, Berkeley, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

...: The Coast Guard will enforce a 1,000 foot safety zone around the Berkeley Pier in position 37[deg]51... Zone; Fourth of July Fireworks, Berkeley Marina, Berkeley, CA AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the safety zone for the Berkeley...

Correlations between Crustal Structure and Slip on the Cascadia Megathrust (Invited)

NASA Astrophysics Data System (ADS)

Trehu, A. M.

2013-12-01

A number of active-source seismic imaging experiments of the Cascadia forearc margin have been conducted over the past three decades. Seismic P-wave velocity models derived from these experiments, when combined with geodetic, potential field, morphological and other data, reveal structures in both the upper and lower plate that can be correlated with current microseismic activity, geodetic signals indicating interplate locking, and apparent segmentation of past large plate boundary earthquakes as determined from onshore and offshore paleoseismic data. These data are being interpreted to construct maps of the apparent seismic velocity structure averaged over several km above and below the expected plate boundary and extending from the region characterized by episodic tremor and slip up dip to the deformation front. Preliminary results for the recent CIET, COAST and Ridge-to-Trench experiments that support, challenge or extend an evolving working model for structural constraints on plate boundary deformation in Cascadia will also be discussed. Other co-PIs who have planned and executed the CIET, COAST and Ridge-to-Trench experiments are listed below with the lead PI for each group listed first. CIET (Cascadia Initiative Science Team): Doug Toomey, Emilie Hooft (both at Un. of Oregon); Bob Dziak (Oregon State Un. NOAA); William Wilcock (Un. Washington); Susan Schwartz (UC Santa Cruz); John Collins, Jeff McGuire (WHOI); Maya Tolstoy (LDEO); Richard Allen (UC Berkeley) COAST (Cascadia Open-Access Seismic Transects): Steve Holbrook (Un. Wyoming); Graham Kent (Un. Nevada Reno); Katie Keranen (Un. Oklahoma); Paul Johnson (Un. Washington); Jackie Caplan-Auerbach (Western Washington Un.); Harold Tobin (Un. Wisconson) Ridge-to-Trench: Suzanne Carbotte, Helene Carton, Geoff Abers (all at LDEO); Pablo Canales (WHOI); Mladen Nedimovic (Dalhousie Un.)

On the suitability of lanthanides as actinide analogs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raymond, Kenneth; Szigethy, Geza

2008-07-01

With the current level of actinide materials used in civilian power generation and the need for safe and efficient methods for the chemical separation of these species from their daughter products and for long-term storage requirements, a detailed understanding of actinide chemistry is of great importance. Due to the unique bonding properties of the f-elements, the lanthanides are commonly used as structural and chemical models for the actinides, but differences in the bonding between these 4f and 5f elements has become a question of immediate applicability to separations technology. This brief overview of actinide coordination chemistry in the Raymond groupmore » at UC Berkeley/LBNL examines the validity of using lanthanide analogs as structural models for the actinides, with particular attention paid to single crystal X-ray diffraction structures. Although lanthanides are commonly accepted as reasonable analogs for the actinides, these comparisons suggest the careful study of actinide materials independent of their lanthanide analogs to be of utmost importance to present and future efforts in nuclear industries. (authors)« less

[Biomedical research from philanthropy to scarcity.

PubMed

Addis, Antonio; De Fiore, Luca; Traversa, Giuseppe

2016-10-01

Some huge information technology companies have increased investment in biomedical research: recently Google, Microsoft, and Facebook. The latter presented the ambitious Zuckerberg-Chan Initiative involving three major Californian universities: UC San Francisco, Berkeley and Stanford. These important private investments arouse reflections. First, investing in scientific research improves the corporate image of the most generous companies and it is a great marketing strategy. Second, the availability of private funds is surely useful, especially if these funds are directed to relevant projects, and produce studies conducted and disseminated in a transparent way. Third, private funding should not replace public ones, representing an integration that will not likely affect the determination of the research agenda, which should remain the prerogative of public institutions. Fourth, the researchers involved in public funded projects should benefit from the margin of freedom that private industry promises, both in the decision of research pathways and in their course. Finally, the scarcity of resources is likely to divert energy and attention of the public researchers and this aspect should be considered by decision makers when determining size and recipients of research funding.

Oxygen vacancy ordering in transition-metal-oxide LaCoO3 films

NASA Astrophysics Data System (ADS)

Biskup, Neven; Salafranca, Juan; Mehta, Virat; Suzuki, Yuri; Pennycook, Stephen; Pantelides, Sokrates; Varela, Maria

2013-03-01

Oxygen vacancies in complex oxides affect the structure and the electronic and magnetic properties. Here we use atomically-resolved Z-contrast imaging, electron-energy-loss spectroscopy and densityfunctional calculations to demonstrate that ordered oxygen vacancies may act as the controlling degree of freedom for the structural, electronic, and magnetic properties of LaCoO3 thin films. We find that epitaxial strain is released through the formation of O vacancy superlattices. The O vacancies donate excess electrons to the Co d-states, resulting in ferromagnetic ordering. The appearance of Peierls-like minigaps followed by strain relaxation triggers a nonlinear rupture of the energy bands, which explains the observed insulating behavior. We conclude that oxygen vacancy ordering constitutes a degree of freedom that can be used to engineer novel behavior in complex-oxide films. Research at ORNL supported by U.S. DOE-BES, Materials Sciences and Engineering Div. and by ORNL's ShaRE User Program (DOE-BES), at UCM by the ERC Starting Inv. Award, at UC Berkeley and LBNL by BES-DMSE, at Vanderbilt by U.S DOE and the McMinn Endowment.

Understanding Global Change: A New Conceptual Framework To Guide Teaching About Planetary Systems And Both The Causes And Effects Of Changes In Those Systems

NASA Astrophysics Data System (ADS)

Levine, J.; Bean, J. R.

2016-12-01

Goals of the Next Generation Science Standards include understanding climate change and learning about ways to moderate the causes and mitigate the consequences of planetary-scale anthropogenic activities that interact synergistically to affect ecosystems and societies. The sheer number and scale of both causes and effects of global change can be daunting for teachers, and the lack of a clear conceptual framework for presenting this material usually leads educators (and textbooks) to present these phenomenon as a disjointed "laundry list." But an alternative approach is in the works. The Understanding Global Change web resource, currently under development at the UC Berkeley Museum of Paleontology, will provide educators with a conceptual framework, graphic models, lessons, and assessment templates for teaching NGSS-aligned, interdisciplinary, global change curricula. The core of this resource is an original informational graphic that presents and relates Earth's global systems, human and non-human factors that produce changes in those systems, and the effects of those changes that scientists can measure.

A tale of two slinkies: learning about scientific models in a student-driven classroom

NASA Astrophysics Data System (ADS)

Gandhi, Punit; Berggren, Calvin; Livezey, Jesse; Olf, Ryan

2014-11-01

We describe a set of conceptual activities and hands-on experiments based around understanding the dynamics of a slinky that is hung vertically and released from rest. The motion, or lack thereof, of the bottom of the slinky after the top is dropped sparks students' curiosity by challenging their expectations and provides context for learning about scientific model building. This curriculum helps students learn about the model building process by giving them an opportunity to enlist their collective intellectual and creative resources to develop and explore two different physical models of the falling slinky system. By engaging with two complementary models, students not only have the opportunity to understand an intriguing phenomenon from multiple perspectives, but also learn deeper lessons about the nature of scientific understanding, the role of physical models, and the experience of doing science. The activities we present were part of a curriculum developed for a week-long summer program for incoming freshmen as a part of the Compass Project at UC Berkeley, but could easily be implemented in a wide range of classrooms at the high school or introductory college level.

European Hands-on Universe

NASA Astrophysics Data System (ADS)

Doran, Rosa; Ferlet, Roger; Gómez de Castro, Ana I.; Hill, Robert; Horellou, Cathy; Mankiewicz, Lech; Melchior, Anne-Laure; Metaxa, Margarita; Zanazzi, Alessandra

2007-08-01

Hands-on Universe is a project born at UC@Berkeley. A project devoted to enrich the teaching of Astronomy within the classroom environment with a different approach, more connected to the new technologies. Its main goals are not only to promote the use of such technologies but also to reawaken on students the taste for STEM (Science, technologies, engineering and math) related issues and also to increase their scientific culture. Eight countries in Europe decided to adopt the method and, funded by MINERVA, formed the European Hands-on Universe. Several resources were produced and a data reduction software developed http://www.euhou.net/.Other European countries are interested and should join this coordinated effort in the near future. At an international level there are 20 countries using this approach. There are plans to develop scientific cooperation among these countries. Pilot scientific research projects in schools are being tested in EU-HOU schools, Russia and USA. There is also a game being developed to be used as a new tool for teaching scientific content in the classroom environment. An effort to develop an international network of scientific / educational collaboration is the next step.

Experiences with lab-centric instruction

NASA Astrophysics Data System (ADS)

Titterton, Nathaniel; Lewis, Colleen M.; Clancy, Michael J.

2010-06-01

Lab-centric instruction emphasizes supervised, hands-on activities by substituting lab for lecture time. It combines a multitude of pedagogical techniques into the format of an extended, structured closed lab. We discuss the range of benefits for students, including increased staff interaction, frequent and varied self-assessments, integrated collaborative activities, and a systematic sequence of activities that gradually increases in difficulty. Instructors also benefit from a deeper window into student progress and understanding. We follow with discussion of our experiences in courses at U.C. Berkeley, and using data from some of these investigate the effects of lab-centric instruction on student learning, procrastination, and course pacing. We observe that the lab-centric format helped students on exams but hurt them on extended programming assignments, counter to our hypothesis. Additionally, we see no difference in self-ratings of procrastination and limited differences in ratings of course pace. We do find evidence that the students who choose to attend lab-centric courses are different in several important ways from students who choose to attend the same course in a non-lab-centric format.

The Swift MIDEX Education and Public Outreach Program

NASA Astrophysics Data System (ADS)

Feigelson, E. D.; Cominsky, L. R.; Whitlock, L. A.

1999-12-01

The Swift satellite is dedicated to an understanding of gamma-ray bursts, the most powerful explosions in the Universe since the Big Bang. A multifaceted E/PO program associated with Swift is planned. Web sites will be constructed, including sophisticated interactive learning environments for combining science concepts with with exploration and critical thinking for high school students. The award-winning instructional television program "What's in the News?", produced by Penn State Public Broadcasting and reaching several million 4th-7th graders, will create a series of broadcasts on Swift and space astronomy. A teachers' curricular guide on space astronomy will be produced by UC-Berkeley's Lawrence Hall of Science as part of their highly successful GEMS guides promoting inquiry-based science education. Teacher workshops will be conducted in the Appalachian region and nationwide to testbed and disseminate these products. We may also assist the production of gamma-ray burst museum exhibits. All aspects of the program will be overseen by a Swift Education Committee and assessed by a professional educational evaluation firm. This effort will be supported by the NASA Swift MIDEX contract to Penn State.

Critical issues for the application of integrated MEMS/CMOS technologies to inertial measurement units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.H.; Ellis, J.R.; Montague, S.

1997-03-01

One of the principal applications of monolithically integrated micromechanical/microelectronic systems has been accelerometers for automotive applications. As integrated MEMS/CMOS technologies such as those developed by U.C. Berkeley, Analog Devices, and Sandia National Laboratories mature, additional systems for more sensitive inertial measurements will enter the commercial marketplace. In this paper, the authors will examine key technology design rules which impact the performance and cost of inertial measurement devices manufactured in integrated MEMS/CMOS technologies. These design parameters include: (1) minimum MEMS feature size, (2) minimum CMOS feature size, (3) maximum MEMS linear dimension, (4) number of mechanical MEMS layers, (5) MEMS/CMOS spacing.more » In particular, the embedded approach to integration developed at Sandia will be examined in the context of these technology features. Presently, this technology offers MEMS feature sizes as small as 1 {micro}m, CMOS critical dimensions of 1.25 {micro}m, MEMS linear dimensions of 1,000 {micro}m, a single mechanical level of polysilicon, and a 100 {micro}m space between MEMS and CMOS. This is applicable to modern precision guided munitions.« less

Global Search Methods for Stellarator Design

NASA Astrophysics Data System (ADS)

Mynick, H. E.; Pomphrey, N.

2001-10-01

We have implemented a new variant Stellopt-DE of the stellarator optimizer Stellopt used by the NCSX team.(A. Reiman, G. Fu, S. Hirshman, D. Monticello, et al., EPS Meeting on Controlled Fusion and Plasma Physics Research, Maastricht, the Netherlands, June 14-18, 1999, (European Physical Society, Petit-Lancy, 1999).) It is based on the ``differential evolution'' (DE) algorithm,(R. Storn, K. Price, U.C. Berkeley Technical Report TR-95-012, ICSI (March, 1995).) a global search method which is far less prone than local algorithms such as the Levenberg-Marquardt method presently used in Stellopt to become trapped in local suboptimal minima of the cost function \\chi. Explorations of stellarator configuration space z to which the DE method has been applied will be presented. Additionally, an accompanying effort to understand the results of this more global exploration has found that a wide range of Quasi-Axisymmetric Stellarators (QAS) previously studied fall into a small number of classes, and we obtain maps of \\chi(z) from which one can see the relative positions of these QAS, and the reasons for the classes into which they fall.

Berkeley Lab Training

Science.gov Websites

Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Help Berkeley Lab Training Welcome Welcome to Berkeley Lab Training! Login to access your LBNL Training Profile. This provides quick access to all of the courses you need. Look below, to learn about different types of training available at

The NASA/NSERC Student Airborne Research Program Land Focus Group - a Paid Training Program in Multi-Disciplinary STEM Research for Terrestrial Remote Sensing

NASA Astrophysics Data System (ADS)

Kefauver, S. C.; Ustin, S.; Davey, S. W.; Furey, B. J.; Gartner, A.; Kurzweil, D.; Siebach, K. L.; Slawsky, L.; Snyder, E.; Trammell, J.; Young, J.; Schaller, E.; Shetter, R. E.

2011-12-01

The Student Airborne Research Program (SARP) of the National Aeronautics and Space Administration (NASA) and the National Suborbital Education and Research Center (NSERC) is a unique six week multidisciplinary paid training program which directly integrates students into the forefront of airborne remote sensing science. Students were briefly trained with one week of lectures and laboratory exercises and then immediately incorporated into ongoing research projects which benefit from access to the DC-8 airborne platform and the MODIS-ASTER Airborne Simulator (MASTER) sensor. Students were split into three major topical categories of Land, Ocean, and Air for the data collection and project portions of the program. This poster details the techniques and structure used for the student integration into ongoing research, professional development, hypothesis building and results as developed by the professor and mentor of the Land focus group. Upon assignment to the Land group, students were issued official research field protocols and split into four field specialty groups with additional specialty reading assignments. In the field each group spent more time in their respective specialty, but also participated in all field techniques through pairings with UC Davis research team members using midday rotations. After the field campaign, each specialty group then gave summary presentations on the techniques, preliminary results, and significance to overall group objectives of their specialty. Then students were required to submit project proposals within the bounds of Land airborne remote sensing science and encouraging, but not requiring the use of the field campaign data. These proposals are then reviewed by the professor and mentor and students are met with one by one to discuss the skills of each student and objectives of the proposed research project. The students then work under the supervision of the mentor and benefit again from professor feedback in a formal practice presentation session. At the end of the six week program, students present to all SARP program focus groups, mentors, professors, and, in addition, NSERC and NASA airborne science and education program directors and personnel.

PREFACE: The IARU International Scientific Congress on Climate Change: Global Risks, Challenges and Decisions (10-12 March, Copenhagen, Denmark)

NASA Astrophysics Data System (ADS)

2009-01-01

In an attempt to make the main results from the Congress on Climate Change: Global Risk, Challenges and Decisions available to the public as early as possible, the steering committee decided to publish all talks and posters presented at the Congress in this unique collection of abstracts, in time for the conference Further to the abstract collection the Congress will publish two more products in the near future as described in the following; a synthesis report with the main conclusions, and a book aimed at an academic audience 1 Two Products from the Congress Two products are being produced based on the presentations and discussions at the Congress The first product will be a synthesis report of the main conclusions from the Congress The synthesis report will be ready in June 2009 The synthesis has the purpose of explaining the current state of understanding man-made climate change and what we can do about it to the non-scientist, ie politicians, media and interested citizens The synthesis will build on the messages presented to the Danish Prime Minister, Mr Anders Fogh Rasmussen, host of the COP15, at the closing session of the Congress These six messages were drafted by the Writing Team (see below) based on input from the session chairs and a reading of the 1600+ abstracts submitted to the Congress The second product is a book aimed at an academic audience The book will include more detailed scientific results from all of the sessions and will be published by Cambridge University Press in 2010 It will be an extension and elaboration of the synthesis report Who's writing the Synthesis Report and the Book? A Writing Team consisting of 12 internationally respected scientists from all continents is responsible for developing both products When the synthesis report has been drafted by the Writing Team, it will be discussed in the Scientific Steering Committee of the Congress and reviewed by the Earth System Science Partnership (ESSP) and a group of experts identified by the IARU universities In keeping with normal scientific practice, a procedure for producing the synthesis report that has been adopted optimises the chances of arriving at a product that will receive a broad backing from the scientific community as being a message that can be sent to the non-scientific community and that explains current understanding in climate change science The Writing Team will also be responsible for writing the book Members of the Writing Team (in alphabetical order) Professor Joe Alcamo, University of Stellenbosch Dr Terry Barker, Cambridge University Professor Daniel Kammen, University of California - Berkeley Professor Rik Leemans, Environmental Systems Analysis Group, Wageningen University Professor Diana Liverman, Oxford University Professor Mohan Munasinghe, Chairman, Munasinghe Institute for Development (MIND) Dr Balgis Osman-Elasha, Higher Council for Environment and Natural Resources (HCENR), Sudan Professor Katherine Richardson, University of Copenhagen Professor John Schellnhuber, Potsdam Institute for Climate Impact Research and visiting professor at the University of Oxford Professor Will Steffen, Australian National University Professor Lord Nicholas Stern, London School of Economics and Political Science (LSE) Professor Ole Wæver, University of Copenhagen 2 Key Messages from the Congress Key Message 1: Climatic Trends Recent observations confirm that, given high rates of observed emissions, the worst-case IPCC scenario trajectories (or even worse) are being realized For many key parameters, the climate system is already moving beyond the patterns of natural variability within which our society and economy have developed and thrived These parameters include global mean surface temperature, sea-level rise, ocean and ice sheet dynamics, ocean acidification, and extreme climatic events There is a significant risk that many of the trends will accelerate, leading to an increasing risk of abrupt or irreversible climatic shifts Key Message 2: Social disruption The research community is providing much more information to support discussions on 'dangerous climate change' Recent observations show that societies are highly vulnerable to even modest levels of climate change, with poor nations and communities particularly at risk Temperature rises above 2°C will be very difficult for contemporary societies to cope with, and will increase the level of climate disruption through the rest of the century Key Message 3: Long-Term Strategy Rapid, sustained, and effective mitigation based on coordinated global and regional action is required to avoid 'dangerous climate change' regardless of how it is defined Weaker targets for 2020 increase the risk of crossing tipping points and make the task of meeting 2050 targets more difficult Delay in initiating effective mitigation actions increases significantly the long-term social and economic costs of both adaptation and mitigation Key Message 4: Equity Dimensions Climate change is having, and will have, strongly differential effects on people within and between countries and regions, on this generation and future generations, and on human societies and the natural world An effective, well-funded adaptation safety net is required for those people least capable of coping with climate change impacts, and a common but differentiated mitigation strategy is needed to protect the poor and most vulnerable Key Message 5: Inaction is Inexcusable There is no excuse for inaction We already have many tools and approaches - economic, technological, behavioral, management - to deal effectively with the climate change challenge But they must be vigorously and widely implemented to achieve the societal transformation required to decarbonize economies A wide range of benefits will flow from a concerted effort to alter our energy economy now, including sustainable energy job growth, reductions in the health and economic costs of climate change, and the restoration of ecosystems and revitalization of ecosystem services Key Message 6: Meeting the Challenge To achieve the societal transformation required to meet the climate change challenge, we must overcome a number of significant constraints and seize critical opportunities These include reducing inertia in social and economic systems; building on a growing public desire for governments to act on climate change; removing implicit and explicit subsidies; reducing the influence of vested interests that increase emissions and reduce resilience; enabling the shifts from ineffective governance and weak institutions to innovative leadership in government, the private sector and civil society; and engaging society in the transition to norms and practices that foster sustainability The editors of the volume are all the session chairs: Professor Agus Sari Dr Aled Jones Science Manager Anders Viksø-Nielsen Dr Andreas Barkman Professor Anette Reenberg Professor Ann Henderson-Sellers Professor Anthony J McMichael Dr Anthony Patt Dr Bette Otto-Bliesner Dr Cameron Hepburn Dr Carlos Nobre Dr Carol Turley Dr Chris Hope Professor Chris Turney Professor Claus Felby Professor Coleen Vogel Professor Dale Jamieson Professor Daniel M Kammen Senior Scientist Detlef F Sprinz Professor Diana Ürge-Vorsatz Professor Dorthe Dahl-Jensen PhD Fatima Denton Director Generel Frances Seymour Dr Frank Jotzo Professor Harold Mooney Director Henrik Bindslev Mr Jamie Pittock Professor Jacquie Burgess Dr James E Hansen Professor Jiahua Pan Dr Jill Jäger Professor Jim Skea Professor Johan Rockström Dr John Christensen Professor John Mitchell Professor John R Porter Professor Joyeeta Gupta Professor Jørgen E Olesen Professor Karen O'Brien Dr Kazuhiko Takeuchi Dr Katrine Krogh Andersen Professor Keith Paustian Professor Ken Caldeira Professor Kevin Anderson Dr Koko Warner Professor Konrad Steffen Professor Liping Zhou Professor Louise Fresco Professor Maria Carmen Lemos Professor Mark Ashton Dr Mark Stafford-Smith Dr Martin Claussen Dr Martin Visbeck Professor Mary Scholes Professor Masahide Kimoto Professor Matthew England Dr Maxwell Boykoff Dr Michael Raupach Professor Nathan Bindoff Professor Nicolas Gruber Professor Niels Elers Koch Professor Ole John Nielsen Professor Ole Wæver Professor Oran Young Dr Pamela Matson Dr Paul Baer Professor Paul Leadley Dr Pep Canadell Professor Pete Smith Professor Peter Gregory Professor Pier Vellinga Dr Rik Leemans Dr Roberto Bertollini Professor Roberto S Rodriguez Professor Scott Denning Dr Sivan Kartha Dr Thomas Downing Dr Tariq Banuri Professor Thomas Heyd Professor Tim Lenton Professor Timmons Roberts Professor Torkil Jønch Clausen Professor Warwick McKibbin Professor Wim C Turkenburg

Lawrence Berkeley National Laboratory 2016 Annual Financial Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Kim, P.; Williams, Kim, P.

FY2016 was a year of significant change and progress at Berkeley Lab. In March, Laboratory Director Michael Witherell assumed his new role when former Lab Director Paul Alivisatos became Vice Chancellor for Research at UC Berkeley. Dr. Witherell has solidified the Lab’s strategy, with a focus on long term science and technology priorities. Large-scale science efforts continued to expand at the Lab, including the Dark Energy Spectroscopic Instrument now heading towards construction, and the LUX-ZEPLIN dark matter detector to be built underground in South Dakota. Another proposed project, the Advanced Light Source-Upgrade, was given preliminary approval and will be themore » Lab’s largest scientific investment in years. Construction of the Integrative Genomics Building began, and will bring together researchers from the Lab’s Joint Genome Institute, now based in Walnut Creek, and the Systems Biology Knowledgebase (K-Base) under one roof. Investment in the Lab’s infrastructure also continues, informed by the Lab’s Infrastructure Strategic Plan. Another important focus is on developing the next generation of scientists with the talent and diversity needed to sustain Berkeley Lab’s scientific leadership and mission contributions to DOE and the Nation. Berkeley Lab received $897.5M in new FY2016 funding, a 12.5% increase over FY2015, for both programmatic and infrastructure activities. While the Laboratory experienced a substantial increase in funding, it was accompanied by only a modest increase in spending, as areas of growth were partially offset by the completion of several major efforts in FY2015. FY2016 costs were $826.9M, an increase of 1.9% over FY2015. Similar to the prior year, the indirect-funded Operations units worked with generally flat budgets to yield more funding for strategic needs. A key challenge for Berkeley Lab continues to be achieving the best balance to fund essential investments, deliver highly effective operational mission support and remain cost-competitive. Through a comprehensive approach to prioritize competing needs, the Lab ended the year in a favorable financial position. The Office of the Chief Financial Officer (OCFO) played a key role in providing analysis and decision support to Executive Leadership, enabling the Lab to enhance its financial management strategies. In FY2016, the OCFO updated its analytic approaches and models to enhance long term financial projections under various funding and investment scenarios, and to assess total cost of ownership for major proposed investments. These improvements provided the new Lab Director and Senior Leadership with more comprehensive information and analytic support for planning and prioritization efforts. Within the OCFO, we focused on core operations and key initiatives defined in our OCFO Strategic Roadmap. The Lab’s Financial System transitioned from stabilization to optimization, with a focus on expanding the financial reporting capabilities considerably. We completed implementation of the eCommerce platform, achieving a notable outcome for the Lab in close partnership with DOE’s Office of Science. In other accomplishments, we launched a financial literacy program to enable Lab managers and staff to understand and execute their financial management and stewardship responsibilities more effectively; made substantial progress in enhancing our Field Finance model that provides financial support to client divisions and areas; developed a business process governance model to define OCFO business processes, clarify roles, and strengthen service delivery; and implemented a Partners in Leadership training program to build leadership capacity among our staff. We completed a ‘refresh’ of our Strategic Roadmap, which now defines our priorities for FY2017-FY2019. As a part of this effort, we made a subtle but important change to the OCFO mission statement to call out the Lab’s research and stewardship mission to sustain the Lab’s science and technology capabilities now and into the future. Berkeley Lab’s FY2016 progress on all fronts - scientific, operations, and financial management – position the Lab to continue bringing science solutions to the world as we charge into the 21st Century.« less

p53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis.

PubMed

Lu, Xiaohong; Yu, Yuanjie; Tan, Shiyun

2017-10-25

Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC. Publications were searched in the PubMed, Embase, EBSCO, Wangfang, and CNKI databases. The overall odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were summarized in this study. Final 19 papers were identified in this meta-analysis, including 1068 patients with UC and 130 normal tissue samples. Immunohistochemical p53 expression was significantly higher in UC without dysplasia and carcinoma (UC group) compared to normal tissue samples (OR = 3.14, P = 0.001), higher in UC with dysplasia than in UC group (OR = 10.76, P < 0.001), and higher in UC with colorectal cancer (CRC) than in UC with dysplasia (OR = 1.69, P = 0.035). Subgroup analysis of ethnicity (UC group vs. normal tissues) showed that p53 expression was correlated with UC in Asians, but not in Caucasians. When UC with dysplasia was compared to UC group, p53 expression was linked to UC with dysplasia among both Asians and Caucasians. When UC-CRC was compared to UC with dysplasia, p53 expression was not associated with UC-CRC in both Caucasians and Asians. p53 expression was closely associated with UC-CRC development. p53 expression showed different ethnic characteristics among different pathological types of UC.

Accomplishments in the Trident Laser Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fernandez, Juan Carlos

Trident has been an extremely productive laser facility, despite its modest size and operating cost in the firmament of high-energy, high-power laser facilities worldwide. More than 150 peer-reviewed journal articles (in 39 different journals) have been published using Trident experimental data, many in high-impact journals such as Nature, Nature Physics, Nature Communications, and Physical Review Letters. More than 230 oral presentations involving research at Trident have been presented at national and international conferences. Trident publications have over 5000 citations in the literature with an h-index of 38. AT least 23 Los Alamos postdoctoral researchers have worked on Trident. In themore » period since its inception in 1992-2007, despite not issuing formal proposal calls for access nor functioning explicitly as a user facility until later, Trident has 170 unique users from more than 30 unique institutions, such as Los Alamos, Lawrence Livermore, and Sandia national laboratories, various University of California campuses, General Atomic, Imperial College, and Ecole Polytechnique. To reinforce its role as an important Los Alamos point of connection to the external research community, at least 20 PhD students did a significant fraction of their thesis work on Trident. Such PhD students include Mike Dunne (Imperial College, 1995) - now director of LCLS and professor at Stanford; David Hoarty (IC, 1997) - scientist at Atomic Weapons Establishment, UK; Dustin Froula (UC Davis, 2002) - Plasma and Ultrafast Physics Group leader at the Laboratory for Laser Energetics and assistant professor at the Physics and Astronomy Department at the University of Rochester; Tom Tierney (UC Irvine, 2002) - scientist at Los Alamos; Eric Loomis (Arizona State U., 2005) - scientist at Los Alamos; and Eliseo Gamboa (University of Michigan, 2013) - scientist at the Linac Coherent Light Source. The work performed on Trident, besides its scientific impact, has also supported the Inertial Confinement Fusion and Weapons research programs at the Laboratory. It also has advanced technologies and techniques that hold significant promise for Los Alamos initiatives, such as MaRIE (the proposed Matter-Radiation Interactions in Extremes experimental facility), and more generally for important societal applications, such as defense, global security, advanced accelerators, fusion energy, radiotherapy, and laser technology. Specific research contributions based on Trident experiments are listed below.« less

Which is riskier: windmills or reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cromie, W.J.

1980-03-01

In 1978, Dr. Herbert Inhaber, a scientist employed by the Atomic Energy Board of Canada, published an evaluation of the health hazards of different energy systems entitled Risk of Energy Production. He concluded that natural gas and nuclear systems are safer than coal- and oil-fired power plants, hydroelectricity, various forms of solar energy, windmills, methanol (wood alcohol), and other nonconventional energy sources. The report and its conclusions drew widespread criticism, particularly from Dr. John P. Holdren, professor of energy and resources, University of California at Berkeley. Holdren and five colleagues wrote a stinging 232-page critique of the Inhaber report. Themore » Council for the Advancement of Science Writing, a nonprofit educational organization of writers and scientists, invited the two to debate the issue in front of an audience of science reporters. The confrontation took place at CASW's 17th Annual New Horizons in Science Briefing in Palo Alto, Calif., on Nov. 5, 1979. An edited transcript of the debate is presented here.« less

Development of a UC781 releasing polyethylene vinyl acetate vaginal ring.

PubMed

McConville, Christopher; Major, Ian; Friend, David R; Clark, Meredith R; Malcolm, R Karl

2012-12-01

UC781 is potent, hydrophobic, non-nucleotide reverse transcriptase inhibitor (NNRTI) against the human immunodeficiency virus (HIV). UC781 is currently being investigated for use as a potential HIV microbicide. A study in rhesus macaques demonstrated that a 100-mg UC781-loaded silicone elastomer vaginal ring released limited amounts of UC781 into the vaginal fluid and tissue after 28 days. The reason for this was due to the hydrophobic nature and limited aqueous solubility of UC781. This study describes the manufacture of UC781-loaded polyethylene vinyl acetate (PEVA) vaginal rings, which have an improved in vitro release rate of UC781 when compared to UC781-loaded silicone elastomer vaginal rings. The study demonstrates that the UC781 in the PEVA rings is mostly in its amorphous form due to the rings being manufactured above UC781's melting point. Furthermore, the rings do not show any signs of UC781 degradation, such as the presence of UC22.

Sneak Preview of Berkeley Lab's Science at the Theatre on June 6th, 2011

ScienceCinema

Sanii, Babak

2017-12-11

Babak Sanii provides a sneak preview of Berkeley Lab's next Science at the Theater Event: Big Thinking: The Power of Nanoscience. Berkeley Lab scientists reveal how nanoscience will bring us cleaner energy, faster computers, and improved medicine. Berkeley Repertory Theatre on June 6th, 2011.

Sneak Preview of Berkeley Lab's Science at the Theatre on June 6th, 2011

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanii, Babak

Babak Sanii provides a sneak preview of Berkeley Lab's next Science at the Theater Event: Big Thinking: The Power of Nanoscience. Berkeley Lab scientists reveal how nanoscience will bring us cleaner energy, faster computers, and improved medicine. Berkeley Repertory Theatre on June 6th, 2011.

Enhancing Earth Science And IT Literacy Through Environmental Science Information Technology Activities

NASA Astrophysics Data System (ADS)

Cuff, K. E.; Molinaro, M.

2004-12-01

The Environmental Science Information Technology Activities (ESITA) program provides grades 9 and 10 students with under-represented minority backgrounds in the East San Francisco Bay Area with real-world opportunities to learn about and apply information technologies through a series of project-based activities related to environmental science. Supported by the NSF Information Technology Experiences for Students and Teachers (ITEST) program, ESITA activities engage students in the use of newly acquired information technology (IT) skills and understandings while performing air and water quality research investigations. One project that ESITA students have become involved in relates to the currently relevant issue of elevated levels of lead found in drinking waters in Washington, D.C. Students based in the Bay Area have initiated and maintained E-mail correspondence with children who attend elementary schools in the D.C. area. After receiving a thorough explanation of required sampling procedures devised by the Bay Area students, the elementary school children have sent 500 ml water samples from their homes and schools to Berkeley along with information about the locations from which the water samples were collected. These samples were then prepared for lead analysis at Lawrence Hall of Science by ESITA students, who used resulting data to perform a preliminary assessment of the geospatial distribution of lead trouble spots throughout Washington, DC. Later, ESITA student scientists will work with students from the UC Berkeley School of Public Health to develop surveys and questionnaires that generate high quality information useful with regard to assessing the impact of the current lead crisis on younger children in the Washington, D.C. area. Through the application of new understandings to current, real-world environmental problems and issues such as that related to lead, positive changes in students' attitudes towards IT and science have occurred, which accompany increases in their content learning and skills acquisition abilities.

Genomic Advances to Improve Biomass for Biofuels (LBNL Science at the Theater)

ScienceCinema

Rokhsar, Daniel [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States)

2018-05-24

Lawrence Berkeley National Lab bioscientist Daniel Rokhsar discusses genomic advances to improve biomass for biofuels. He presented his talk Feb. 11, 2008 in Berkeley, California as part of Berkeley Lab's community lecture series. Rokhsar works with the U.S. Department of Energy's Joint Genome Institute and Berkeley Lab's Genomics Division.

Berkeley Lab Scientist Named MacArthur "Genius" Fellow for Audio

Science.gov Websites

Preservation Research | Berkeley Lab Berkeley Lab A-Z Index Directory Submit Web People Navigation Berkeley Lab Search Submit Web People Close About the Lab Leadership/Organization Calendar News to digitally recover a 128-year-old recording of Alexander Graham Bell's voice, enabling people to

Genomic Advances to Improve Biomass for Biofuels (Genomics and Bioenergy)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rokhsar, Daniel

2008-02-11

Lawrence Berkeley National Lab bioscientist Daniel Rokhsar discusses genomic advances to improve biomass for biofuels. He presented his talk Feb. 11, 2008 in Berkeley, California as part of Berkeley Lab's community lecture series. Rokhsar works with the U.S. Department of Energy's Joint Genome Institute and Berkeley Lab's Genomics Division.

Genomic Advances to Improve Biomass for Biofuels (LBNL Science at the Theater)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rokhsar, Daniel

2008-02-11

Lawrence Berkeley National Lab bioscientist Daniel Rokhsar discusses genomic advances to improve biomass for biofuels. He presented his talk Feb. 11, 2008 in Berkeley, California as part of Berkeley Lab's community lecture series. Rokhsar works with the U.S. Department of Energy's Joint Genome Institute and Berkeley Lab's Genomics Division.

Adsorption of Dissolved Metals in the Berkeley Pit using Thiol-Functionalized Self-Assembled Monolayers on Mesoporous Supports (Thiol-SAMMS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Betancourt, Amaury P.; Mattigod, Shas V.; Wellman, Dawn M.

2010-03-07

The Berkeley Pit in Butte, Montana, is heavily contaminated with dissolved metals. Adsorption and extraction of these metals can be accomplished through the use of a selective adsorbent. For this research, the adsorbent used was thiol-functionalized Self-Assembled Monolayers on Mesoporous Supports (thiol-SAMMS), which was developed at Pacific Northwest National Laboratory (PNNL). Thiol-SAMMS selectively binds to numerous types of dissolved metals. The objective of this research was to evaluate the loading and kinetics of aluminum, beryllium, copper, and zinc on thiol-SAMMS. For the loading tests, a series of Berkeley Pit water to thiol-SAMMS ratios (mL:g) were tested. These ratios were 1000:1,more » 500:1, 100:1, and 50:1. Berkeley Pit water is acidic (pH {approx} 2.5). This can affect the performance of SAMMS materials. Therefore, the effect of pH was evaluated by conducting parallel series of loading tests wherein the Berkeley Pit water was neutralized before or after addition of thiol-SAMMS, and a series of kinetics tests wherein the Berkeley Pit water was neutralized before addition of thiol-SAMMS for the first test and was not neutralized for the second test. For the kinetics tests, one Berkeley Pit water to thiol-SAMMS ratio was tested, which was 2000:1. The results of the loading and kinetics tests suggest that a significant decrease in dissolved metal concentration at Berkeley Pit could be realized through neutralization of Berkeley Pit water. Thiol-SAMMS technology has a limited application under the highly acidic conditions posed by the Berkeley Pit. However, thiol-SAMMS could provide a secondary remedial technique which would complete the remedial system and remove dissolved metals from the Berkeley Pit to below drinking water standards.« less

Determining the Discharge Rate from a Submerged Oil Leaks using ROV Video and CFD study

NASA Astrophysics Data System (ADS)

Saha, Pankaj; Shaffer, Frank; Shahnam, Mehrdad; Savas, Omer; Devites, Dave; Steffeck, Timothy

2016-11-01

The current paper reports a technique to measure the discharge rate by analyzing the video from a Remotely Operated Vehicle (ROV). The technique uses instantaneous images from ROV video to measure the velocity of visible features (turbulent eddies) along the boundary of an oil leak jet and subsequently classical theory of turbulent jets is imposed to determine the discharge rate. The Flow Rate Technical Group (FRTG) Plume Team developed this technique that manually tracked the visible features and produced the first accurate government estimates of the oil discharge rate from the Deepwater Horizon (DWH). For practical application this approach needs automated control. Experiments were conducted at UC Berkeley and OHMSETT that recorded high speed, high resolution video of submerged dye-colored water or oil jets and subsequently, measured the velocity data employing LDA and PIV software. Numerical simulation have been carried out using experimental submerged turbulent oil jets flow conditions employing LES turbulence closure and VOF interface capturing technique in OpenFOAM solver. The CFD results captured jet spreading angle and jet structures in close agreement with the experimental observations. The work was funded by NETL and DOI Bureau of Safety and Environmental Enforcement (BSEE).

A continuously self regenerating high-flux neutron-generator facility

NASA Astrophysics Data System (ADS)

Rogers, A. M.; Becker, T. A.; Bernstein, L. A.; van Bibber, K.; Bleuel, D. L.; Chen, A. X.; Daub, B. H.; Goldblum, B. L.; Firestone, R. B.; Leung, K.-N.; Renne, P. R.; Waltz, C.

2013-10-01

A facility based on a next-generation, high-flux D-D neutron generator (HFNG) is being constructed at UC Berkeley. The current generator, designed around two RF-driven multicusp deuterium ion sources, is capable of producing a neutron output of >1011 n/s. A specially designed titanium-coated copper target located between the ion sources accelerates D+ ions up to 150 keV, generating 2.45 MeV neutrons through the d(d,3He)n fusion reaction. Deuterium in the target is self loaded and regenerating through ion implantation, enabling stable and continuous long-term operation. The proposed science program is focused on pioneering advances in the 40Ar/39Ar dating technique for geochronology, new nuclear data measurements, basic nuclear science research including statistical model studies of radiative-strength functions and level densities, and education. An overview of the facility and its unique capabilities as well as first measurements from the HFNG commissioning will be presented. Work supported by NSF Grant No. EAR-0960138, U.S. DOE LBL Contract No. DE-AC02-05CH11231, and U.S. DOE LLNL Contract No. DE-AC52-07NA27344.

Construction, characterization, and environmental testing of a Laue lens prototype using Fe and Al crystals

NASA Astrophysics Data System (ADS)

Wade, C.; Barrière, N. M.; Tomsick, J. A.; Hanlon, L.; Boggs, S. E.; Lowell, A.; von Ballmoos, P.; Massahi, S.

2018-07-01

Laue lenses use Bragg diffraction to concentrate soft γ-rays onto a detector. This decoupling of the collecting area from the detector volume can generate a significant increase in sensitivity for applications in astrophysics and nuclear medicine. A demonstrator lens was constructed at the UC Berkeley's Space Sciences Laboratory in 2014 by gluing 48 Fe and Al diffracting crystals to an aluminium substrate. The goal was to demonstrate a fast and accurate assembly technique that is compatible with the large number of crystals required to fabricate a Laue lens telescope for astronomical observations. We present here the lens design, the assembly technique we used, and the results of measurements of the angular misalignments before and after curing of the glue and during environmental testing (thermal, vacuum, and vibration). We conclude that our alignment technique is fast enough to assemble a full lens made of several thousand crystals. The achieved alignment accuracy had an average of 32.7‧‧ and a standard deviation of 44.1‧‧. The accuracy could be improved by using an alternative glue or by having better control over the asymmetry angle resulting from the crystal cut.

Two Decades (almost) of Keck Observations of Io

NASA Astrophysics Data System (ADS)

De Pater, I.; Davies, A. G.; de Kleer, K.

2015-12-01

We have regularly observed Io with the 10-m Keck Telescope since 1998, initially using the speckle imaging technique, and switching to Adaptive Optics techniques when this became available in 2001. In this talk we will discuss several eruptions that we witnessed, and present 20-30 year timelines of thermal emission from Pele, Pillan, Janus Patera, Kanehekili Fluctus, and Loki Patera, updating timelines in recent publications [1, 2] with additional Keck adaptive optics data obtained between 2002 and 2015. These new timelines are the most comprehensive plots ever produced of the volcanic thermal emission variability for these or any other locations on Io, utilizing data from multiple ground- and space-based assets. Our continuing multi-decadal observing program forms the basis for charting the variability of Io's volcanic activity, of great importance for understanding the evolution of the Galilean satellite system, and with the expectation of new missions to the jovian system in the next decade. Acknowledgements: This research is in part supported by NSF grant AST-1313485 to UC Berkeley. AGD is supported by a grant from the NASA OPR Program. References: [1] Davies et al. (2012) Icarus, 221, 466-470. [2] Rathbun and Spencer (2010) Icarus, 209, 625-630.

Hybrid solar collector using nonimaging optics and photovoltaic components

NASA Astrophysics Data System (ADS)

Winston, Roland; Yablonovitch, Eli; Jiang, Lun; Widyolar, Bennett K.; Abdelhamid, Mahmoud; Scranton, Gregg; Cygan, David; Kozlov, Alexandr

2015-08-01

The project team of University of California at Merced (UC-M), Gas Technology Institute, and Dr. Eli Yablonovitch of University of California at Berkeley developed a novel hybrid concentrated solar photovoltaic thermal (PV/T) collector using nonimaging optics and world record single-junction Gallium arsenide (GaAs) PV components integrated with particle laden gas as thermal transfer and storage media, to simultaneously generate electricity and high temperature dispatchable heat. The collector transforms a parabolic trough, commonly used in CSP plants, into an integrated spectrum-splitting device. This places a spectrum-sensitive topping element on a secondary reflector that is registered to the thermal collection loop. The secondary reflector transmits higher energy photons for PV topping while diverting the remaining lower energy photons to the thermal media, achieving temperatures of around 400°C even under partial utilization of the solar spectrum. The collector uses the spectral selectivity property of Gallium arsenide (GaAs) cells to maximize the exergy output of the system, resulting in an estimated exergy efficiency of 48%. The thermal media is composed of fine particles of high melting point material in an inert gas that increases heat transfer and effectively stores excess heat in hot particles for later on-demand use.

Construction of a Thermal Vacuum Chamber for Environment Test of Triple CubeSat Mission TRIO-CINEMA

NASA Astrophysics Data System (ADS)

Jeon, Jeheon; Lee, Seongwhan; Yoon, Seyoung; Seon, Jongho; Jin, Ho; Lee, Donghun; Lin, Robert P.

2013-12-01

TRiplet Ionospheric Observatory-CubeSat for Ion, Neutron, Electron & MAgnetic fields (TRIO-CINEMA) is a CubeSat with 3.14 kg in weight and 3-U (10 × 10 × 30 cm) in size, jointly developed by Kyung Hee University and UC Berkeley to measure magnetic fields of near Earth space and detect plasma particles. When a satellite is launched into orbit, it encounters ultrahigh vacuum and extreme temperature. To verify the operation and survivability of the satellite in such an extreme space environment, experimental tests are conducted on the ground using thermal vacuum chamber. This paper describes the temperature control device and monitoring system suitable for CubeSat test environment using the thermal vacuum chamber of the School of Space Research, Kyung Hee University. To build the chamber, we use a general purpose thermal analysis program and NX 6.0 TMG program. We carry out thermal vacuum tests on the two flight models developed by Kyung Hee University based on the thermal model of the TRIO-CINEMA satellite. It is expected from this experiment that proper operation of the satellite in the space environment will be achieved.

Enhanced cell survival and paracrine effects of mesenchymal stem cells overexpressing hepatocyte growth factor promote cardioprotection in myocardial infarction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Liyan; Liu, Xiaolin; Zhang, Yuelin

Poor cell survival post transplantation compromises the therapeutic benefits of mesenchymal stem cells (MSCs) in myocardial infarction (MI). Hepatocyte growth factor (HGF) is an important cytokine for angiogenesis, anti-inflammation and anti-apoptosis. This study aimed to evaluate the cardioprotective effects of MSCs overexpressing HGF in a mouse model of MI. The apoptosis of umbilical cord-derived MSCs (UC-MSCs) and HGF-UC-MSCs under normoxic and hypoxic conditions was detected. The conditioned medium (CdM) of UC-MSCs and HGF-UC-MSCs under a hypoxic condition was harvested and its protective effect on neonatal cardiomyocytes (NCMs) exposed to a hypoxic challenge was examined. UC-MSCs and HGF-UC-MSCs were transplanted intomore » the peri-infarct region in mice following MI and heart function assessed 4 weeks post transplantation. The apoptosis of HGF-UC-MSCs under hypoxic conditions was markedly decreased compared with that of UC-MSCs. NCMs treated with HGF-UC-MSC hypoxic CdM (HGF-UC-MSCs-hy-CdM) exhibited less cell apoptosis in response to hypoxic challenge than those treated with UC-MSC hypoxic CdM (UC-MSCs-hy-CdM). HGF-UC-MSCs-hy-CdM released the inhibited p-Akt and lowered the enhanced ratio of Bax/Bcl-2 induced by hypoxia in the NCMs. HGF-UC-MSCs-hy-CdM expressed higher levels of HGF, EGF, bFGF and VEGF than UC-MSCs-hy-CdM. Transplantation of HGF-UC-MSCs or UC-MSCs greatly improved heart function in the mouse model of MI. Compared with UC-MSCs, transplantation of HGF-UC-MSCs was associated with less cardiomyocyte apoptosis, enhanced angiogenesis and increased proliferation of cardiomyocytes. This study may provide a novel therapeutic strategy for MSC-based therapy in cardiovascular disease.« less

The Undergraduate Origins of PhD Economists: The Berkeley Experience

ERIC Educational Resources Information Center

Olney, Martha L.

2015-01-01

The University of California, Berkeley sends more undergraduate students to economics PhD programs than any other public university. While this fact is surely a function of its size, there may be lessons from the Berkeley experience that others could adopt. To investigate why Berkeley generates so many economics PhD students, the author convened…

Microsoft Licenses Berkeley Lab's Home Energy Saver Code for Its Energy

Science.gov Websites

-based tool for calculating energy use in residential buildings. About one million people visit the Home Management Software | Berkeley Lab Berkeley Lab A-Z Index Directory Submit Web People Navigation Berkeley Lab Search Submit Web People Close About the Lab Leadership/Organization Calendar News

The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis.

PubMed

Smolinska, A; Bodelier, A G L; Dallinga, J W; Masclee, A A M; Jonkers, D M; van Schooten, F-J; Pierik, M J

2017-05-01

To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non-invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non-UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease. To investigate whether VOCs are able to differentiate between active UC, UC in remission and non-UC colitis. UC patients participated in a 1-year study. Clinical activity index, blood, faecal and breath samples were collected at each out-patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index <3, C-reactive protein <5 mg/L and faecal calprotectin <100 μg/g) were included for cross-sectional analysis. Non-UC colitis was confirmed by stool culture or radiological evaluation. Breath samples were analysed by gas chromatography time-of-flight mass spectrometry and kernel-based method to identify discriminating VOCs. In total, 72 UC (132 breath samples; 62 active; 70 remission) and 22 non-UC-colitis patients (22 samples) were included. Eleven VOCs predicted active vs. inactive UC in an independent internal validation set with 92% sensitivity and 77% specificity (AUC 0.94). Non-UC colitis patients could be clearly separated from active and inactive UC patients with principal component analysis. Volatile organic compounds can accurately distinguish active disease from remission in UC and profiles in UC are clearly different from profiles in non-UC colitis patients. VOCs have demonstrated potential as new non-invasive biomarker to monitor inflammation in UC. © 2017 John Wiley & Sons Ltd.

Providing Context for Complexity: Using Infographics and Conceptual Models to Teach Global Change Processes

NASA Astrophysics Data System (ADS)

Bean, J. R.; White, L. D.

2015-12-01

Understanding modern and historical global changes requires interdisciplinary knowledge of the physical and life sciences. The Understanding Global Change website from the UC Museum of Paleontology will use a focal infographic that unifies diverse content often taught in separate K-12 science units. This visualization tool provides scientists with a structure for presenting research within the broad context of global change, and supports educators with a framework for teaching and assessing student understanding of complex global change processes. This new approach to teaching the science of global change is currently being piloted and refined based on feedback from educators and scientists in anticipation of a 2016 website launch. Global change concepts are categorized within the infographic as causes of global change (e.g., burning of fossil fuels, volcanism), ongoing Earth system processes (e.g., ocean circulation, the greenhouse effect), and the changes scientists measure in Earth's physical and biological systems (e.g., temperature, extinctions/radiations). The infographic will appear on all website content pages and provides a template for the creation of flowcharts, which are conceptual models that allow teachers and students to visualize the interdependencies and feedbacks among processes in the atmosphere, hydrosphere, biosphere, and geosphere. The development of this resource is timely given that the newly adopted Next Generation Science Standards emphasize cross-cutting concepts, including model building, and Earth system science. Flowchart activities will be available on the website to scaffold inquiry-based lessons, determine student preconceptions, and assess student content knowledge. The infographic has already served as a learning and evaluation tool during professional development workshops at UC Berkeley, Stanford University, and the Smithsonian National Museum of Natural History. At these workshops, scientists and educators used the infographic to highlight how their research and activities reinforce conceptual links among global change topics. Pre- and post-workshop assessment results and responses to questionnaires have guided the refinement of classroom activities and assessment tools utilizing flowcharts as models for global change processes.

Astronomy in Denver: Centenary of the 1918 total solar eclipse across Denver

NASA Astrophysics Data System (ADS)

Stencel, Robert E.

2018-06-01

Totality during the 2017 August 21 solar eclipse (Saros 145) traveled along a path across the United States similar to that which occurred for the eclipse on 1918 June 8 (Saros 126), but with a less west-northerly track. This placed Denver and its then new Chamberlin Observatory in the path of totality. Denver University astronomy Professor Herbert Howe offered use of the Chamberlin Observatory 20-inch f/15 refractor, with its Clark doublet lens and Saegmueller mounting, in service of eclipse-related research. In preparation for the eclipse, Professor Howe and assistants had spent the last three months of 1917, refurbishing mechanical aspects of the telescope. Edwin Frost, then Director of Yerkes Observatory expressed interest and made a reconnaissance visit to the area in September 1917, reporting results in the Feb. 1918 issue of Popular Astronomy ( http://adsabs.harvard.edu/abs/1918PA.....26R.103F ). Frank Schlesinger, then director of Allegheny Observatory, asked if he might attach a special camera for star photography to the telescope at the eclipse, to test displacement of stars, in order to test a prediction of relativity theory. Among the additional visiting astronomical luminaries present on that June day in 1918 were Annie J. Cannon (Harvard), John Duncan (Wellesley), Herbert R. Morgan (U.S. Naval Observatory) and Robert Trumpler (Berkeley). To learn the results of all this eclipse preparedness, you will need to attend my talk in order to get “the rest of the story” or visit our twitter feed at: https://twitter.com/Chamberlin_Obs .

FY2014 LBNL LDRD Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ho, Darren

2015-06-01

Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE’s National Laboratory System, Berkeley Lab supports DOE’s missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation. The LDRD program supports Berkeley Lab’s mission in many ways. First, because LDRD funds can be allocated within a relatively short time frame, Berkeley Lab researchers can support the mission of the Department of Energy (DOE) and serve the needs of the nationmore » by quickly responding to forefront scientific problems. Second, LDRD enables Berkeley Lab to attract and retain highly qualified scientists and to support their efforts to carry out worldleading research. In addition, the LDRD program also supports new projects that involve graduate students and postdoctoral fellows, thus contributing to the education mission of Berkeley Lab.« less

Untitled Document

Science.gov Websites

, contact: Saul Perlmutter (saul(at)lbl(dot)gov) University of California Berkeley, CA 94720 A. Spadafora (alspadafora(at)lbl(dot)gov) Lawrence Berkeley National Laboratory 1 Cyclotron Rd. Berkeley, CA 94720

Final Report: Biological and Synthetic Nanostructures Controlled at the Atomistic Level

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williamson, A; van Buuren, T

2007-02-21

Nanotechnology holds great promise for many application fields, ranging from the semiconductor industry to medical research and national security. Novel, nanostructured materials are the fundamental building blocks upon which all these future nanotechnologies will be based. In this Strategic Initiative (SI) we conducted a combined theoretical and experimental investigation of the modeling, synthesis, characterization, and design techniques which are required to fabricate semiconducting and metallic nanostructures with enhanced properties. We focused on developing capabilities that have broad applicability to a wide range of materials and can be applied both to nanomaterials that are currently being developed for nanotechnology applications andmore » also to new, yet to be discovered, nanomaterials. During this 3 year SI project we have made excellent scientific progress in each of the components of this project. We have developed first-principles techniques for modeling the structural, electronic, optical, and transport properties of materials at the nanoscale. For the first time, we have simulated nanomaterials both in vacuum and in aqueous solution. These simulation capabilities harness the worldleading computational resources available at LLNL to model, at the quantum mechanical level, systems containing hundreds of atoms and thousands of electrons. Significant advances in the density functional and quantum Monte Carlo techniques employed in this project were developed to enable these techniques to scale up to simulating realistic size nanostructured materials. We have developed the first successful techniques for chemically synthesizing crystalline silicon and germanium nanoparticles and nanowires. We grew the first macroscopic, faceted superlattice crystals from these nanoparticles. We have also advanced our capabilities to synthesize semiconductor nanoparticles using physical vapor deposition techniques so that we are now able to control of the size, shape and surface structure of these nanoparticles. We have made advances in characterizing the surface of nanoparticles using x-ray absorption experiments. Throughout this SI a number of long-term, strategic external collaborations have been established. These collaborations have resulted in 30 joint publications, strategic hires of postdocs and graduate students from these groups into groups at LLNL and the submission of joint research grants. We have developed collaborations on the theory and modeling of nanomaterials with the groups of Profs. Ceder and Marzari (MIT), Crespi (Penn State), Freeman (Northwestern), Grossman and Lester (UC Berkeley), Mitas (North Carolina State), and Needs (Cambridge). We are collaborating with Dr. Alivisatos's group in the Molecular Foundry at Lawrence Berkeley Laboratory on the fabrication, characterization and modeling of inorganic nanomaterials. We are working with Prof. Majumdar's group at UC Berkeley on the characterization of nanomaterials. We are working with the molecular diamond group at Chevron-Texaco who has developed a process for extracting mono-disperse samples of nano-scale diamonds from crude oil. We are collaborating with Dr. Chen at UCSF to develop CdSe nanoparticle-biolabels. As a result of the outstanding scientific achievements and the long-term collaborations developed during this strategic initiative we have been extremely successful in obtaining external funding to continue and grow this research activity at the LLNL. We have received two DARPA grants to support the further development of our computational modeling techniques and to develop carbon nanotube based molecular separation devices. We have received two new Office of Science BES grants to support our nanomaterials modeling and synthesis projects. We have received funding from the NA22 office of DOE to develop the materials modeling capabilities begun in this SI for modeling detector materials. We have received funding from Intel Corporation to apply the modeling techniques developed in this initiative to examine silicon nanowires fabricated on computer chips. We are also pursuing several additional sources of funding from BES, the DHS, and NIH to support the continuation of the research programs developed in this SI. The remainder of this report and the attached publications describe the background to this SI research project and the details of the scientific achievements that have been made.« less

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Search MSD Go MSD - Materials Investigators Division Staff Facilities and Centers Staff Jobs Safety Personnel Resources Committees In Case of

Tradeoffs Between Synchronization, Communication, and Work in Parallel Linear Algebra Computations

DTIC Science & Technology

2014-01-25

Demmel Electrical Engineering and Computer Sciences University of California at Berkeley Technical Report No. UCB/EECS-2014- 8 http...www.eecs.berkeley.edu/Pubs/TechRpts/2014/EECS-2014- 8 .html January 25, 2014 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...University of California at Berkeley,Electrical Engineering and Computer Sciences,Berkeley,CA,94720 8 . PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

Targeting Transcription Elongation Machinery for Breast Cancer Therapy

DTIC Science & Technology

2016-05-01

Luo CONTRACTING ORGANIZATION: University of California, Berkeley Berkeley, CA 94704 REPORT DATE: May 2016 TYPE OF REPORT: Annual PREPARED FOR...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER University of California, Berkeley BERKELEY, CA 94704 9. SPONSORING...molecules. We have employed the CRISPR /Cas9 genome-editing tool to knock out the gene encoding the SEC component AFF4 or knock in a mutant cyclin T1 (AAG

Targeting Transcription Elongation Machinery for Breast Cancer Therapy

DTIC Science & Technology

2016-05-01

Zhou CONTRACTING ORGANIZATION: University of California, Berkeley Berkeley, CA 94704 REPORT DATE: May 2016 TYPE OF REPORT: Annual Report...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER AND ADDRESS(ES) University of California, Berkeley Berkeley, CA ...without affecting the Brd4 or PTEFb molecules. We have employed the CRISPR /Cas9 genome-editing tool to knock out the gene encoding the SEC component AFF4

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Synthesis Condensed Matter and Materials Physics Scattering and Instrumentation Science Centers Center for Berkeley National Laboratory 1 Cyclotron Road MS 66R0200 Berkeley CA 94720 510-486-4957 A U.S. Department

Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation

PubMed Central

Shono, Akemi; Yoshida, Makiko; Yamana, Keiji; Thwin, Khin Kyae Mon; Kuroda, Jumpei; Kurokawa, Daisuke; Koda, Tsubasa; Nishida, Kosuke; Ikuta, Toshihiko; Mizobuchi, Masami; Taniguchi-Ikeda, Mariko

2017-01-01

Mesenchymal stem cells (MSCs) are a heterogeneous cell population that is isolated initially from the bone marrow (BM) and subsequently almost all tissues including umbilical cord (UC). UC-derived MSCs (UC-MSCs) have attracted an increasing attention as a source for cell therapy against various degenerative diseases due to their vigorous proliferation and differentiation. Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. In the present study, we isolated UC-MSCs from 23 infants delivered at 22–40 weeks of gestation and analyzed their gene expression and cell proliferation. Microarray analysis revealed that global gene expression in preterm UC-MSCs was distinct from term UC-MSCs. WNT signaling impacts on a variety of tissue stem cell proliferation and differentiation, and its pathway genes were enriched in differentially expressed genes between preterm and term UC-MSCs. Cell proliferation of preterm UC-MSCs was significantly enhanced compared to term UC-MSCs and counteracted by WNT signaling inhibitor XAV939. Furthermore, WNT2B expression in UC-MSCs showed a significant negative correlation with gestational age (GA). These results suggest that WNT signaling is involved in the regulation of GA-dependent UC-MSC proliferation. PMID:29138639

Nuclear Medicine at Berkeley Lab: From Pioneering Beginnings to Today (LBNL Summer Lecture Series)

ScienceCinema

Budinger, Thomas [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Nuclear Medicine & Functional Imaging

2018-01-23

Summer Lecture Series 2006: Thomas Budinger, head of Berkeley Lab's Center for Functional Imaging, discusses Berkeley Lab's rich history pioneering the field of nuclear medicine, from radioisotopes to medical imaging.

Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis.

PubMed

Kevans, D; Tyler, A D; Holm, K; Jørgensen, K K; Vatn, M H; Karlsen, T H; Kaplan, G G; Eksteen, B; Gevers, D; Hov, J R; Silverberg, M S

2016-03-01

There is an unexplained association between ulcerative colitis [UC] and primary sclerosing cholangitis [PSC], with the intestinal microbiota implicated as an important factor. The study aim was to compare the structure of the intestinal microbiota of patients with UC with and without PSC. UC patients with PSC [PSC-UC] and without PSC [UC] were identified from biobanks at Oslo University Hospital, Foothills Hospital Calgary and Mount Sinai Hospital Toronto. Microbial DNA was extracted from colonic tissue and sequencing performed of the V4 region of the 16S rRNA gene on Illumina MiSeq. Sequences were assigned to operational taxonomic units [OTUs] using Quantitative Insights Into Microbial Ecology [QIIME]. Microbial alpha diversity, beta diversity, and relative abundance were compared between PSC-UC and UC phenotypes. In all, 31 PSC-UC patients and 56 UC patients were included. Principal coordinate analysis [PCoA] demonstrated that city of sample collection was the strongest determinant of taxonomic profile. In the Oslo cohort, Chao 1 index was modestly decreased in PSC-UC compared with UC [p = 0.04] but did not differ significantly in the Calgary cohort. No clustering by PSC phenotype was observed using beta diversity measures. For multiple microbial genera there were nominally significant differences between UC and PSC-UC, but results were not robust to false-discovery rate correction. No strong PSC-specific microbial associations in UC patients consistent across different cohorts were identified. Recruitment centre had a strong effect on microbial composition. Future studies should include larger cohorts to increase power and the ability to control for confounding factors. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis.

PubMed

Parian, Alyssa; Limketkai, Berkeley; Koh, Joyce; Brant, Steven R; Bitton, Alain; Cho, Judy H; Duerr, Richard H; McGovern, Dermot P; Proctor, Deborah D; Regueiro, Miguel D; Rioux, John D; Schumm, Phil; Taylor, Kent D; Silverberg, Mark S; Steinhart, A Hillary; Hernaez, Ruben; Lazarev, Mark

2017-08-01

Early appendectomy is inversely associated with the development of UC. However, the impact of appendectomy on the clinical course of UC is controversial, generally favouring a milder disease course. We aim to describe the effect appendectomy has on the disease course of UC with focus on the timing of appendectomy in relation to UC diagnosis. Using the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium database of patients with UC, the risk of colectomy was compared between patients who did and did not undergo appendectomy. In addition, we performed a meta-analysis of studies that examined the association between appendectomy and colectomy. 2980 patients with UC were initially included. 111 (4.4%) patients with UC had an appendectomy; of which 63 were performed prior to UC diagnosis and 48 after diagnosis. In multivariable analysis, appendectomy performed at any time was an independent risk factor for colectomy (OR 1.9, 95% CI 1.1 to 3.1), with appendectomy performed after UC diagnosis most strongly associated with colectomy (OR 2.2, 95% CI 1.1 to 4.5). An updated meta-analysis showed appendectomy performed either prior to or after UC diagnosis had no effect on colectomy rates. Appendectomy performed at any time in relation to UC diagnosis was not associated with a decrease in severity of disease. In fact, appendectomy after UC diagnosis may be associated with a higher risk of colectomy. These findings question the proposed use of appendectomy as treatment for UC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions.

PubMed

Damian, Festo; Fabian, Judit; Friend, David R; Kiser, Patrick F

2010-08-30

In this work, we evaluated the chemical stability profiles of UC781 based solutions to identify excipients that stabilize the microbicidal agent UC781. When different antioxidants were added to UC781 in sulfobutylether-beta-cyclodextrin (SBE-beta-CD) solutions and subjected to a 50 degrees C stability study, it was observed that EDTA was a better stabilizing agent than sodium metabisulfite, glutathione or ascorbic acid. Some antioxidants accelerated the degradation of UC781, suggesting metal-catalyzed degradation of UC781. Furthermore, we observed substantial degradation of UC781 when stored in 1% Tween 80 and 1% DMSO solutions alone or in those with 10mM EDTA. On the other hand, improved stability of UC781 in the presence of 100 and 200mM of EDTA was observed in these solutions. The addition of both EDTA and citric acid in the stock solutions resulted in recovery of more than 60% of UC781 after 12 weeks. Generally, 10% SBE-beta-CD in the presence of EDTA and citric acid stabilized UC781 solutions: the amount of UC781 recovered approaching 95% after 12 weeks of storage at 40 degrees C. We also showed that the desulfuration reaction of the UC781 thioamide involves oxygen by running solution stability studies in deoxygenated media. Improved stability of UC781 in the present study indicates that the incorporation of EDTA, citric acid and SBE-beta-CD and the removal of oxygen in formulations of this drug will aid in increasing the stability of UC781 where solutions of the drug are required. Published by Elsevier B.V.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, Sabin; Schlegel, David

Lawrence Berkeley National Laboratory physicist and dark energy hunter David Schlegel chats with Sabin Russell, former San Francisco Chronicle reporter turned Berkeley Lab science writer, June 22, 2011. Their conversation is the first installment of "Sit Down With Sabin," a weekly conversation hosted by Russell. Over the course of five conversations with Berkeley Lab staff this summer, Russell will explore the ups and downs of innovative science — all without the aid of PowerPoint slides. Brought to you by Berkeley Lab Public Affairs.

Disposition and metabolism of 2,3-( UC)dichloropropene in rats after inhalation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bond, J.A.; Medinsky, M.A.; Dutcher, J.S.

1985-01-01

2,3-Dichloropropene (2,3-DCP) is a constituent of some commercially available preplant soil fumigants for the control of plant parasitic nematodes. The purpose of this investigation was to determine the disposition and metabolism of 2,3-( UC)DCP in rats after inhalation. Male Fischer-344 rats were exposed nose-only to a vapor concentration of 250 nmol 2,3-( UC)DCP/liter air (7.5 ppm; 25C, 620 Torr) for 6 hr. Blood samples were taken during exposure, and urine, feces, expired air, and tissues were collected for up to 65 hr after exposure. Urinary excretion was the major route of elimination of UC (55% of estimated absorbed 2,3-DCP). Half-timemore » for elimination of UC in urine was 9.8 +/- 0.05 hr (anti x +/- SE). Half-time for elimination of UC feces (17% of absorbed 2,3-DCP) was 12.9 +/- 0.14 hr (anti x +/- SE). Approximately 1 and 3% of the estimated absorbed 2,3-( UC)DCP were exhaled as either 2,3-( UC)DCP or UCO2, respectively. Concentrations of UC in blood increased during 240 min of exposure, after which no further increases in blood concentration of UC were seen. UC was widely distributed in tissues analyzed after a 6-hr exposure of rats to 2,3-( UC)DCP. Urinary bladder (150 nmol/g), nasal turbinates (125 nmol/g), kidneys (84 nmol/g), small intestine (61 nmol/g), and liver (35 nmol/g) were tissues with the highest concentrations of UC immediately after exposure. Over 90% of the UC in tissues analyzed was 2,3-DCP metabolites. Half-times for elimination of UC from tissues examined ranged from 3 to 11 hr. The data from this study indicate that after inhalation 2,3-DCP is metabolized in tissues and readily excreted. 21 references. 2 figures, 4 tables.« less

Human Umbilical Cord Mesenchymal Stem Cells: Subpopulations and Their Difference in Cell Biology and Effects on Retinal Degeneration in RCS Rats.

PubMed

Wang, L; Li, P; Tian, Y; Li, Z; Lian, C; Ou, Q; Jin, C; Gao, F; Xu, J-Y; Wang, J; Wang, F; Zhang, J; Zhang, J; Li, W; Tian, H; Lu, L; Xu, G-T

2017-01-01

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are potential candidates for treating retinal degeneration (RD). To further study the biology and therapeutic effects of the hUC-MSCs on retinal degeneration. Two hUC-MSC subpopulations, termed hUC-MSC1 and hUC-MSC2, were isolated by single-cell cloning method and their therapeutic functions were compared in RCS rat, a RD model. Although both subsets satisfied the basic requirements for hUC-MSCs, they were significantly different in morphology, proliferation rate, differentiation capacity, phenotype and gene expression. Furthermore, only the smaller, fibroblast-like, faster growing subset hUC-MSC1 displayed stronger colony forming potential as well as adipogenic and osteogenic differentiation capacities. When the two subsets were respectively transplanted into the subretinal spaces of RCS rats, both subsets survived, but only hUC-MSC1 expressed RPE cell markers Bestrophin and RPE65. More importantly, hUC-MSC1 showed stronger rescue effect on the retinal function as indicated by the higher b-wave amplitude on ERG examination, thicker retinal nuclear layer, and decreased apoptotic photoreceptors. When both subsets were treated with interleukin-6, mimicking the inflammatory environment when the cells were transplanted into the eyes with degenerated retina, hUC-MSC1 expressed much higher levels of trophic factors in comparison with hUC-MSC2. The data here, in addition to prove the heterogeneity of hUC-MSCs, confirmed that the stronger therapeutic effects of hUC-MSC1 were attributed to its stronger anti-apoptotic effect, paracrine of trophic factors and potential RPE cell differentiation capacity. Thus, the subset hUC-MSC1, not the other subset or the ungrouped hUC-MSCs should be used for effective treatment of RD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Receptivity of a Cryogenic Coaxial Gas-Liquid Jet to Acoustic Disturbances (Briefing Charts)

DTIC Science & Technology

2014-03-01

meas = Δt Δs Uc,meas 2/12/1 0 2/12/1 0 , i iio thc UUU      DISTRIBUTION STATEMENT A. Approved for public release; distribution unlimited...this point, dynamic pressures are approximately equal. Uc Uo – Uc Uc – Ui (Uo > Ui) 2/12/1 2/12/1 io iioo c UUU      St = Uc fnatD If St, D, Uc

Long-term outcome of patients with distal ulcerative colitis and inflammation of the appendiceal orifice.

PubMed

Naves, Juan E; Lorenzo-Zúñiga, Vicente; Marín, Laura; Mañosa, Míriam; Oller, Blanca; Moreno, Vicente; Zabana, Yamile; Boix, Jaume; Cabré, Eduard; Domènech, Eugeni

2011-12-01

Skip inflammation of the appendiceal orifice has been described in distal UC (UC-IAO) but long-term clinical outcomes are poorly established. Our aim was to evaluate the long-term clinical outcomes of UC-IAO as compared to classic distal UC. Patients with UC-IAO were identified from the local IBD database. Disease outcome and therapeutic requirements during follow-up were accurately collected, and compared with a control group of patients with distal UC without peri-appendiceal involvement matched by disease extent (proctitis/distal), smoking habit, and date and age at diagnosis. Fourteen UC patients were found to have UC-IAO, most of them with initial extent of UC limited to the rectum. All patients were initially managed with mesalazine administered orally (28.5%), topically (28.5%), or in combination (43%). After a median follow-up of 78 months (interquartile range--IQR 45-123) most UC-IAO patients were successfully managed with oral and/or topical aminosalicylates. Only one of them developed proximal disease progression. As compared to controls, no differences in clinical outcomes or therapeutic requirements were found. Patients with UC-IAO tend to present a mild course, with a low probability to develop proximal progression of disease extent or to require immunosuppressive therapy or colectomy.

Receptivity of a Cryogenic Coaxial Liquid Jet to Acoustic Disturbances

DTIC Science & Technology

2014-05-21

i iio thc UUU DISTRIBUTION STATEMENT A. Approved for public release; distribution unlimited. PA Clearance 14208 12Place Proper DISTRIBUTION STATEMENT...dynamic pressures are approximately equal. Uc Uo – Uc Uc – Ui (Uo > Ui) 2/12/1 2/12/1 io iioo c UUU St = Uc fnatD If St, D, Uc are held constant then

The Khachaturyan theory of elastic inclusions: Recollections and results

NASA Astrophysics Data System (ADS)

Morris, J. W.

2010-01-01

In keeping with the assignment, this paper has two parts. The first is a personal recollection of my interactions with Professor Armen Khachaturyan since he first visited Berkeley in the 1970s. The second part is a review of the Khachaturyan formulation of the theory of elastic inclusions, with emphasis on results found since his classic monograph on the Theory of Structural Transformations in Solids [Wiley, New York, 1983]. The focus here is on the shapes and habits of coherent inclusions. The basic theory is presented, briefly, to exhibit Khachaturyan's results for the strain and energy within a coherent inclusion and show that the elastic energy is minimal for a thin-plate morphology with a definite habit. The preferred habit of the thin-plate inclusion is then discussed and computed for inclusions with dyadic strain (including the dislocation loop) and coherent inclusions with orthorhombic or simpler symmetry. This is followed by a discussion of the evolution of precipitate shape during coarsening, including the theory of the spontaneous splitting of coarsening precipitates and the development of octahedral or tetrahedral shapes.

Transgenes and transgressions: scientific dissent as heterogeneous practice.

PubMed

Delborne, Jason A

2008-08-01

Although scholars in science and technology studies have explored many dynamics and consequences of scientific controversy, no coherent theory of scientific dissent has emerged. This paper proposes the elements of such a framework, based on understanding scientific dissent as a set of heterogeneous practices. I use the controversy over the presence of transgenic DNA in Mexican maize in the early 2000s to point to a processual model of scientific dissent. 'Contrarian science' includes knowledge claims that challenge the dominant scientific trajectory, but need not necessarily lead to dissent. 'Impedance' represents efforts to undermine the credibility of contrarian science (or contrarian scientists) and may originate within or outside of the scientific community. In the face of impedance, contrarian scientists may become dissenters. The actions of the scientist at the center of the case study, Professor Ignacio Chapela of the University of California, Berkeley, demonstrate particular practices of scientific dissent, ranging from 'agonistic engagement' to 'dissident science'. These practices speak not only to functional strategies of winning scientific debate, but also to attempts to reconfigure relations among scientists, publics, institutions, and politics that order knowledge production.

Ulcerative colitis-associated colorectal cancer

PubMed Central

Yashiro, Masakazu

2014-01-01

The association between ulcerative colitis (UC) and colorectal cancer (CRC) has been acknowledged. One of the most serious and life threatening consequences of UC is the development of CRC (UC-CRC). UC-CRC patients are younger, more frequently have multiple cancerous lesions, and histologically show mucinous or signet ring cell carcinomas. The risk of CRC begins to increase 8 or 10 years after the diagnosis of UC. Risk factors for CRC with UC patients include young age at diagnosis, longer duration, greater anatomical extent of colonic involvement, the degree of inflammation, family history of CRC, and presence of primary sclerosing cholangitis. CRC on the ground of UC develop from non-dysplastic mucosa to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma. Colonoscopy surveillance programs are recommended to reduce the risk of CRC and mortality in UC. Genetic alterations might play a role in the development of UC-CRC. 5-aminosalicylates might represent a favorable therapeutic option for chemoprevention of CRC. PMID:25469007

News from Online: More Spectroscopy

NASA Astrophysics Data System (ADS)

Sweeney Judd, Carolyn

1999-09-01

Absorption (one of three tools) (http://mc2.cchem.berkeley.edu/Chem1A/solar/applets/absorption/ index.html).

Evaporative cooling in a Bose-Einstein condensation ( http://www.colorado.edu/physics/2000/applets/bec.html). Let's start with the spectrum--the electromagnetic spectrum, of course. Go to the EMSpectrum Explorer at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/EMSpectrum /emspectrum.html. Not only do you get information about wavelength, frequency, and energy, but you also get a handy converter that will calculate frequency, wavelength, and energy when one value is entered. And there is more. For example, clicking on red light of 680 nanometers reveals that mitochondria, the power plants of cells, are about the same size as this wavelength, which is also used for photosynthesis. Interesting food for thought! From the EMSpectrum Explorer, go to the Light and Energy page at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/index.html for three Colors of Light Tools. The Color from Emission tool ( http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/emission/index.html) illustrates additive color by mixing differing amounts of Red, Blue, and Green light. Then look at the Color from Absorption tool at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/absorption/index.html. The image from the applet shows the white beam and three filters. Take out the blue, green, and red components by altering the scroll bars or text boxes. The third tool, Removing Color with a Single Filter from Colored Light at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/single/index.html, uses a single filter to take out various colors. Excellent for explaining the theory behind the operation of a basic spectrometer. The Light and Energy tools module, which received support from the National Science Foundation, has been developed under the direction of the ChemLinks Coalition--headed by Beloit College; and The ModularChem Consortium, MC2, headed by the University of California at Berkeley. The Project Director is Marco Molinaro from the University of California at Berkeley; the Project Manager is Susan Walden; Susan Ketchner and Leighanne McConnaughey are also members of the team for this excellent teaching site. For your information, all of the applets will soon be moving, along with the MC2 site, but the old addresses will still work. The next place to explore is Physics 2000 at http://www.colorado.edu/physics/2000/introduction.html. The introductory graphic is a harbinger of good things to come: move the negatively charged particle and see the water molecule spin in response to the position of the charged particle. One goal of the Physics 2000 Educational Initiative is to make physics more accessible to students and people of all ages. Sounds like a good goal for all sciences! One of the first sections is called Einstein's Legacy. Here you can find spectral lines explained in terms of team colors for rival football squads ( http://www.colorado.edu/physics/2000/quantumzone/index.html). Choose from 20 elements to see characteristic emission spectra. The cartoon teachers and students help explain emission spectra. Great applets compare the Bohr atom and the Schrödinger model as well as emission and absorption ( http://www.colorado.edu/physics/2000/quantumzone/schroedinger.html). Einstein's Legacy has many topics: X-rays and CAT Scans, Electromagnetic Waves and Particles, the Quantum Atom, Microwave Ovens, Lasers, and TV & Laptop Screens. Several topics also have sections for the advanced student. One of those advanced sections is part of the second major section of Physics 2000: The Atomic Lab. Two topics are Interference Experiments and Bose-Einstein Condensate. An applet illustrating Laser Cooling is at http://www.colorado.edu/physics/2000/bec/lascool1.html. Next go on to Evaporative Cooling at http://www.colorado.edu/physics/2000/bec/evap_cool.html. The cartoon professors begin the explanation with a picture of steam rising from a cup of hot coffee. Next is an applet with atoms in a parabolic magnetic trap at http://www.colorado.edu/physics/2000/applets/bec.html. The height of the magnetic trap can be changed in order to allow for escape of the most energetic atoms, resulting in cooling so that the Bose-Einstein Condensate is formed. Physics 2000 demands robust computing power. Check the system requirements on the introductory screen before venturing too far into this site. Martin V. Goldman, from the University of Colorado at Boulder, is the Director of Physics 2000, which received support from the Colorado Commission on Higher Education and the National Science Foundation. David Rea is the Technical Director, and many others help make this excellent site possible. Mark your calendars: October 31 through December 3, 1999! Bookmark this site-- http://www.ched-ccce.org/confchem/1999/d/index.html --and sign up. The Winter 1999 CONFCHEM Online Conference will focus on Developments in Spectroscopy and Innovative Strategies for Teaching Spectroscopy in the Undergraduate Curriculum. Scott Van Bramer of Widener University is the conference chair. Experts will present six papers, each to be followed by online discussions. CONFCHEM Online Conferences are sponsored by the American Chemical Society Division of Chemical Education's Committee on Computers in Chemical Education (CCCE). Several Online Conferences are held each year--all are well worth your time. World Wide Web Addresses EMSpectrum Explorer http://mc2.cchem.berkeley.edu/chemcnx/light_energy/EMSpectrum/emspectrum.html Light and Energy http://mc2.cchem.berkeley.edu/chemcnx/light_energy/index.html Emission Spectrum Java Applet http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/emission/index.html Absorption Java Applet http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/absorption/index.html Removing Color with a Single Filter from Colored Light http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/single/index.html Physics 2000 http://www.colorado.edu/physics/2000/introduction.html Einstein's Legacy: Spectral lines http://www.colorado.edu/physics/2000/quantumzone/index.html Einstein's: Schrödinger's Atom http://www.colorado.edu/physics/2000/quantumzone /schroedinger.html The Atomic Lab: Laser Cooling http://www.colorado.edu/physics/2000/bec/lascool1.html The Atomic Lab: Evaporative Cooling in a Bose­Einstein Condensation http://www.colorado.edu/physics/2000/bec/evap_cool.html The Winter 1999 CONFCHEM Online Conference will focus on Developments in Spectroscopy and Innovative Strategies for Teaching Spectroscopy in the Undergraduate Curriculum http://www.ched-ccce.org/confchem/1999/d/index.html access date for all sites: July 1999

40 CFR 81.341 - South Carolina.

Code of Federal Regulations, 2014 CFR

2014-07-01

... County X Anderson County X Bamberg County X Barnwell County X Beaufort County X Berkeley County X Calhoun... County X Berkeley County X Calhoun County X Charleston County X Cherokee County X Chester County X... Beaufort County Berkeley County Calhoun County Charleston County Cherokee County Chester County...

Berkeley Screen: a set of 96 solutions for general macromolecular crystallization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pereira, Jose H.; McAndrew, Ryan P.; Tomaleri, Giovani P.

Using statistical analysis of the Biological Macromolecular Crystallization Database, combined with previous knowledge about crystallization reagents, a crystallization screen called the Berkeley Screen has been created. Correlating crystallization conditions and high-resolution protein structures, it is possible to better understand the influence that a particular solution has on protein crystal formation. Ions and small molecules such as buffers and precipitants used in crystallization experiments were identified in electron density maps, highlighting the role of these chemicals in protein crystal packing. The Berkeley Screen has been extensively used to crystallize target proteins from the Joint BioEnergy Institute and the Collaborative Crystallography programmore » at the Berkeley Center for Structural Biology, contributing to several Protein Data Bank entries and related publications. The Berkeley Screen provides the crystallographic community with an efficient set of solutions for general macromolecular crystallization trials, offering a valuable alternative to the existing commercially available screens. The Berkeley Screen provides an efficient set of solutions for general macromolecular crystallization trials.« less

Berkeley Screen: a set of 96 solutions for general macromolecular crystallization

DOE PAGES

Pereira, Jose H.; McAndrew, Ryan P.; Tomaleri, Giovani P.; ...

2017-09-05

Using statistical analysis of the Biological Macromolecular Crystallization Database, combined with previous knowledge about crystallization reagents, a crystallization screen called the Berkeley Screen has been created. Correlating crystallization conditions and high-resolution protein structures, it is possible to better understand the influence that a particular solution has on protein crystal formation. Ions and small molecules such as buffers and precipitants used in crystallization experiments were identified in electron density maps, highlighting the role of these chemicals in protein crystal packing. The Berkeley Screen has been extensively used to crystallize target proteins from the Joint BioEnergy Institute and the Collaborative Crystallography programmore » at the Berkeley Center for Structural Biology, contributing to several Protein Data Bank entries and related publications. The Berkeley Screen provides the crystallographic community with an efficient set of solutions for general macromolecular crystallization trials, offering a valuable alternative to the existing commercially available screens. The Berkeley Screen provides an efficient set of solutions for general macromolecular crystallization trials.« less

Invasive urothelial carcinoma exhibiting basal cell immunohistochemical markers: A variant of urothelial carcinoma associated with aggressive features.

PubMed

Mai, Kien T; Truong, Luan D; Ball, Christopher G; Williams, Phillip; Flood, Trevor A; Belanger, Eric C

2015-08-01

We characterize invasive urothelial carcinoma (UC) exhibiting urothelial basal cell immunohistochemical markers. Consecutive invasive UCs were immunostained with CK20 and urothelial basal cell markers, cytokeratin 5 (CK5)/CD44. Immunostaining for CK5 and CD44 was scored as follows: positive for staining of more than 25% thickness of the epithelial nest or epithelium and low for lesser immunoreactivity. Invasive urothelial carcinoma (UC) exhibiting positive CK5/CD44 staining was designated as basal-like UC (BUC). In this study, of 251 invasive UC (pT1 in 57% and pT2-4 in 43%), BUC accounted for 40% of cases (accounting for most pT2-4 UC) and often presented as non-papillary UC without previous history of UC. In addition, BUC exhibited uniform nuclei with lesser degree of atypia than non BUC and decreased or negative cytokeratin 20 reactivity. Nested and microcystic variants of UC immunohistochemically stained as BUCs. Invasive non-BUCs were often papillary with marked cytologic atypia and pleomorphism, and accounted for most pT1 UC. The rates of perivesical invasion, lymph node and distant metastases were higher for BUC than non-BUC. All nine cases with absent/minimal residual in situ UC in 102 radical cystectomy specimens were from invasive non-BUC. BUC is distinguished from non-BUC due to this aggressive behavior, distinct immunohistochemical profile, and predominant non-papillary architecture. Our findings are consistent with recent studies identifying a subtype of muscle-invasive UC with molecular expression of basal cell and luminal cell molecular profiles. Our study further supports categorizing invasive UCs into these subtypes with different biological behaviors, possibly contributing to better therapeutic strategies. Copyright © 2015 Elsevier GmbH. All rights reserved.

Energy Frontier Research Centers (EFRCs): A Response to Five Challenges for Science and the Imagination (2011 EFRC Summit, panel session)

ScienceCinema

Alivisatos, Paul; Crabtree, George; Dresselhaus, Mildred; Ratner, Mark

2018-05-14

A distinguished panel of speakers at the 2011 EFRC Summit looks at the EFRC Program and how it serves as a response to "Five Challenges for Science and the Imagination”, the culminating report that arose from a series of Basic Research Needs workshops. The panel members are Paul Alivisatos, the Director of Lawrence Berkeley National Laboratory, George Crabtree, Distinguished Fellow at Argonne National Laboratory, Mildred Dresselhause, Institute Professor at the Massachusetts Institute of Technology, and Mark Ratner, Professor at Northwestern University. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

The homing of human umbilical cord-derived mesenchymal stem cells and the subsequent modulation of macrophage polarization in type 2 diabetic mice.

PubMed

Yin, Yaqi; Hao, Haojie; Cheng, Yu; Gao, Jieqing; Liu, Jiejie; Xie, Zongyan; Zhang, Qi; Zang, Li; Han, Weidong; Mu, Yiming

2018-07-01

Umbilical cord-derived mesenchymal stem cells (UC-MSCs), with both immunomodulatory and pro-regenerative properties, are promising for the treatment of type 2 diabetes mellitus (T2DM). As efficient cell therapy largely relies on appropriate homing to target tissues, knowing where and to what extent injected UC-MSCs have homed is critically important. However, bio-distribution data for UC-MSCs in T2DM subjects are extremely limited. Beneficial effects of UC-MSCs on T2DM subjects are associated with increased M2 macrophages, but no systemic evaluation of M2 macrophages has been performed in T2DM individuals. In this study, we treated T2DM mice with CM-Dil-labelled UC-MSCs. UC-MSC infusion not only exerted anti-diabetic effects but also alleviated dyslipidemia and improved liver function in T2DM mice. To compare UC-MSC migration between T2DM and normal subjects, a collection of normal mice also received UC-MSC transplantation. UC-MSCs homed to the lung, liver and spleen in both normal and T2DM recipients. Specifically, the spleen harbored the largest number of UC-MSCs. Unlike normal mice, a certain number of UC-MSCs also homed to pancreatic islets in T2DM mice, which suggested that UC-MSC homing may be closely related to tissue damage. Moreover, the number of M2 macrophages in the islets, liver, fat and muscle significantly increased after UC-MSC infusion, which implied a strong link between the increased M2 macrophages and the improved condition in T2DM mice. Additionally, an M2 macrophage increase was also observed in the spleen, suggesting that UC-MSCs might exert systemic effects in T2DM individuals by modulating macrophages in immune organs. Copyright © 2018 Elsevier B.V. All rights reserved.

Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq.

PubMed

Maeda, Shingo; Tomiyasu, Hirotaka; Tsuboi, Masaya; Inoue, Akiko; Ishihara, Genki; Uchikai, Takao; Chambers, James K; Uchida, Kazuyuki; Yonezawa, Tomohiro; Matsuki, Naoaki

2018-04-27

Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is necessary to improve our understanding of progression, diagnosis, and treatment of iUC. Companion canines are a preferred animal model of iUC due to spontaneous tumor development and similarity to human disease in terms of histopathology, metastatic behavior, and treatment response. However, the comprehensive molecular characterization of canine iUC is not well documented. In this study, we performed transcriptome analysis of tissue samples from canine iUC and normal bladders using an RNA sequencing (RNA-Seq) approach to identify key molecular pathways in canine iUC. Total RNA was extracted from bladder tissues of 11 dogs with iUC and five healthy dogs, and RNA-Seq was conducted. Ingenuity Pathway Analysis (IPA) was used to assign differentially expressed genes to known upstream regulators and functional networks. Differential gene expression analysis of the RNA-Seq data revealed 2531 differentially expressed genes, comprising 1007 upregulated and 1524 downregulated genes, in canine iUC. IPA revealed that the most activated upstream regulator was PTGER2 (encoding the prostaglandin E 2 receptor EP2), which is consistent with the therapeutic efficiency of cyclooxygenase inhibitors in canine iUC. Similar to human iUC, canine iUC exhibited upregulated ERBB2 and downregulated TP53 pathways. Biological functions associated with cancer, cell proliferation, and leukocyte migration were predicted to be activated, while muscle functions were predicted to be inhibited, indicating muscle-invasive tumor property. Our data confirmed similarities in gene expression patterns between canine and human iUC and identified potential therapeutic targets (PTGER2, ERBB2, CCND1, Vegf, and EGFR), suggesting the value of naturally occurring canine iUC as a relevant animal model for human iUC.

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

PubMed Central

Deng, Yinan; Zhang, Yingcai; Ye, Linsen; Zhang, Tong; Cheng, Jintao; Chen, Guihua; Zhang, Qi; Yang, Yang

2016-01-01

Human UC-MSCs are regarded as an attractive alternative to BM-MSCs for clinical applications due to their easy preparation, higher proliferation and lower immunogenicity. However, the mechanisms underlying immune suppression by UC-MSCs are still unclear. We studied the mechanism of inhibition by UC-MSCs during the differentiation of monocytes into DCs and focused on the specific source and the role of the involved cytokines. We found that UC-MSCs suppressed monocyte differentiation into DCs and instructed monocytes towards other cell types, with clear decreases in the expression of co-stimulatory molecules, in the secretion of inflammatory factors and in allostimulatory capacity. IL6, HGF and IL10 might be involved in this process because they were detected at higher levels in a coculture system. UC-MSCs produce IL-6 and HGF, and neutralization of IL-6 and HGF reversed the suppressive effect of UC-MSCs. IL10 was not produced by UC-MSCs but was exclusively produced by monocytes after exposure to UC-MSCs, IL-6 or HGF. In summary, we found that the UC-MSC-mediated inhibitory effect was dependent on IL6 and HGF secreted by UC-MSCs and that this effect induced monocyte-derived cells to produce IL10, which might indirectly strengthen the suppressive effect of UC-MSCs. PMID:27917866

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF.

PubMed

Deng, Yinan; Zhang, Yingcai; Ye, Linsen; Zhang, Tong; Cheng, Jintao; Chen, Guihua; Zhang, Qi; Yang, Yang

2016-12-05

Human UC-MSCs are regarded as an attractive alternative to BM-MSCs for clinical applications due to their easy preparation, higher proliferation and lower immunogenicity. However, the mechanisms underlying immune suppression by UC-MSCs are still unclear. We studied the mechanism of inhibition by UC-MSCs during the differentiation of monocytes into DCs and focused on the specific source and the role of the involved cytokines. We found that UC-MSCs suppressed monocyte differentiation into DCs and instructed monocytes towards other cell types, with clear decreases in the expression of co-stimulatory molecules, in the secretion of inflammatory factors and in allostimulatory capacity. IL6, HGF and IL10 might be involved in this process because they were detected at higher levels in a coculture system. UC-MSCs produce IL-6 and HGF, and neutralization of IL-6 and HGF reversed the suppressive effect of UC-MSCs. IL10 was not produced by UC-MSCs but was exclusively produced by monocytes after exposure to UC-MSCs, IL-6 or HGF. In summary, we found that the UC-MSC-mediated inhibitory effect was dependent on IL6 and HGF secreted by UC-MSCs and that this effect induced monocyte-derived cells to produce IL10, which might indirectly strengthen the suppressive effect of UC-MSCs.

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78 FR 29022 - Safety Zone; Fourth of July Fireworks, Berkeley Marina, Berkeley, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... Marina Fourth of July Fireworks display in the Captain of the Port, San Francisco area of responsibility... Guard will enforce a 1,000 foot safety zone around the Berkeley Pier in approximate position 37[deg]51... radius 1,000 [[Page 29023

Berkeley Lab - Materials Sciences Division

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Free energy of steps using atomistic simulations

NASA Astrophysics Data System (ADS)

Freitas, Rodrigo; Frolov, Timofey; Asta, Mark

The properties of solid-liquid interfaces are known to play critical roles in solidification processes. Particularly special importance is given to thermodynamic quantities that describe the equilibrium state of these surfaces. For example, on the solid-liquid-vapor heteroepitaxial growth of semiconductor nanowires the crystal nucleation process on the faceted solid-liquid interface is influenced by the solid-liquid and vapor-solid interfacial free energies, and also by the free energies of associated steps at these faceted interfaces. Crystal-growth theories and mesoscale simulation methods depend on quantitative information about these properties, which are often poorly characterized from experimental measurements. In this work we propose an extension of the capillary fluctuation method for calculation of the free energy of steps on faceted crystal surfaces. From equilibrium atomistic simulations of steps on (111) surfaces of Copper we computed accurately the step free energy for different step orientations. We show that the step free energy remains finite at all temperature up to the melting point and that the results obtained agree with the more well established method of thermodynamic integration if finite size effects are taken into account. The research of RF and MA at UC Berkeley were supported by the US National Science Foundation (Grant No. DMR-1105409). TF acknowledges support through a postdoctoral fellowship from the Miller Institute for Basic Research in Science.

Demonstrating Climate Change and the Water Cycle to Fifth Grade Students

NASA Astrophysics Data System (ADS)

Murphy, J. G.

2005-12-01

Scientists in academia often want to share their knowledge of and enthusiasm for science with K-12 students, but feel wary of the time commitment and logistical details involved with volunteer work. As a PhD student at UC Berkeley, I participated in the Community in the Classroom program, organized by the non-profit Community Resources for Science. CRS acts as the liaison between local schools and scientists in the community, taking care of all the administrative details regarding the classroom visits. Volunteers are asked to prepare a fun, hands-on presentation for a specific grade level, which is linked to elementary science standards. I chose to visit several fifth grade classrooms and talk about the connection between climate change and the water cycle in California. My presentation included a demonstration of the greenhouse effect, an experiment to see where the water on the outside of a cold glass comes from, and an investigation into the role of temperature in the phase changes of water, using plastic containers, icepacks and mitten warmers. The students were encouraged to make predictions about the impact of climate change on the water cycle based on their recent observations. I will share my demonstrations, discuss feedback from the students and teachers and offer suggestions to those interested in volunteer teaching.

Search for Nuclear Excitation by Electronic Transition in U-235

NASA Astrophysics Data System (ADS)

Chodash, P. A.; Norman, E. B.; Burke, J. T.; Wilks, S. C.; Casperson, R. J.; Swanberg, E. L.; Wakeling, M. A.; Cordeiro, T. J.

2013-10-01

Nuclear excitation by electronic transition (NEET) is a rare nuclear excitation that is predicted to occur in numerous isotopes, including U-235. When a nuclear transition matches the energy and the multipolarity of an electronic transition, there is a possibility that NEET will occur. If NEET were to occur in U-235, the nucleus would be excited to its 1/2 + isomeric state that subsequently decays by internal conversion with a decay energy of 77 eV and a half-life of 26 minutes. Theory predicts that NEET can occur in partially ionized uranium plasma with a charge state of 23 +. A pulsed Nd:YAG laser operating at 1064 nm with a pulse energy of 780 mJ and a pulse width of 9 ns was used to generate the uranium plasma. The plasma was collected on a plate and the internal conversion electrons were focused onto a microchannel plate detector by a series of electrostatic lenses. Depleted uranium and highly enriched uranium samples were used for the experiment. Preliminary results will be presented. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344. This work was further supported by the U.S. DHS, UC Berkeley, and the NNIS Fellowship.

[Basic biological characteristics of mesenchymal stem cells derived from bone marrow and human umbilical cord].

PubMed

Han, Zhen-Xia; Shi, Qing; Wang, Da-Kun; Li, Dong; Lyu, Ming

2013-10-01

Bone marrow (BM) and umbilical cord (UC) are the major sources of mesenchymal stem cells for therapeutics. This study was aimed to compare the basic biologic characteristics of bone marrow-derived and umbilical cord derived-mesenchymal stem cells (BM-MSC and UC-MSC) and their immunosuppressive capability in vitro. The BM-MSC and UC-MSC were cultured and amplified under same culture condition. The growth kinetics, phenotypic characteristics and immunosuppressive effects of UC-MSC were compared with those of BM-MSC.Gene chip was used to compare the genes differentially expressed between UC-MSC and BM-MSC. The results showed that UC-MSC shared most of the characteristics of BM-MSC, including morphology and immunophenotype. UC-MSC could be ready expanded for 30 passages without visible changes. However, BM-MSC grew slowly, and the mean doubling time increased notably after passage 6. Both UC-MSC and BM-MSC could inhibit phytohemagglutinin-stimulated peripheral blood mononuclear cell proliferation, in which BM-MSC mediated more inhibitory effect. Compared with UC-MSC, BM-MSC expressed more genes associated with immune response. Meanwhile, the categories of up-regulated genes in UC-MSC were concentrated in organ development and growth. It is concluded that the higher proliferation capacity, low human leukocyte antigen-ABC expression and immunosuppression make UC-MSC an excellent alternative to BM-MSC for cell therapy. The differences between BM-MSC and UC-MSC gene expressions can be explained by their ontogeny and different microenvironment in origin tissue. These differences can affect their efficacy in different therapeutic applications.

Molecular Foundry Workshop draws overflow crowd to BerkeleyLab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robinson, Art

2002-11-27

Nanoscale science and technology is now one of the top research priorities in the United States. With this background, it is no surprise that an overflow crowd or more than 350 registrants filled two auditoriums to hear about and contribute ideas for the new Molecular Foundry during a two-day workshop at the Lawrence Berkeley National Laboratory (Berkeley Lab). Scheduled to open for business at Berkeley Labin early 2006, the Molecular Foundry is one of three Nanoscale Science Research Centers (NSRCs) put forward for funding by the DOE's Office of Basic Energy Sciences (BES).

A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis

PubMed Central

Chen, Lijian; Liu, Meiling; Zhang, Nan; Zhang, Li; Luo, Yuanwei; Liu, Zhenzhong; Dai, Lijun; Jiang, Yiguo

2016-01-01

As a common toxic metal, lead has significant neurotoxicity to brain development. Long non-coding RNAs (lncRNAs) function in multiple biological processes. However, whether lncRNAs are involved in lead-induced neurotoxicity remains unclear. Uc.173 is a lncRNA from a transcribed ultra-conservative region (T-UCR) of human, mouse and rat genomes. We established a lead-induced nerve injury mouse model. It showed the levels of Uc.173 decreased significantly in hippocampus tissue and serum of the model. We further tested the expression of Uc.173 in serum of lead-exposed children, which also showed a tendency to decrease. To explore the effects of Uc.173 on lead-induced nerve injury, we overexpressed Uc.173 in an N2a mouse nerve cell line and found Uc.173 had an inhibitory effect on lead-induced apoptosis of N2a. To investigate the molecular mechanisms of Uc.173 in apoptosis associated with lead-induced nerve injury, we predicted the target microRNAs of Uc.173 by using miRanda, TargetScan and RegRNA. After performing quantitative real-time PCR and bioinformatics analysis, we showed Uc.173 might inter-regulate with miR-291a-3p in lead-induced apoptosis and regulate apoptosis-associated genes. Our study suggests Uc.173 significantly inhibits the apoptosis of nerve cells, which may be mediated by inter-regulation with miRNAs in lead-induced nerve injury. PMID:26683706

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

PubMed

Visschedijk, Marijn C; Alberts, Rudi; Mucha, Soren; Deelen, Patrick; de Jong, Dirk J; Pierik, Marieke; Spekhorst, Lieke M; Imhann, Floris; van der Meulen-de Jong, Andrea E; van der Woude, C Janneke; van Bodegraven, Adriaan A; Oldenburg, Bas; Löwenberg, Mark; Dijkstra, Gerard; Ellinghaus, David; Schreiber, Stefan; Wijmenga, Cisca; Rivas, Manuel A; Franke, Andre; van Diemen, Cleo C; Weersma, Rinse K

2016-01-01

Genome-wide association studies have revealed several common genetic risk variants for ulcerative colitis (UC). However, little is known about the contribution of rare, large effect genetic variants to UC susceptibility. In this study, we performed a deep targeted re-sequencing of 122 genes in Dutch UC patients in order to investigate the contribution of rare variants to the genetic susceptibility to UC. The selection of genes consists of 111 established human UC susceptibility genes and 11 genes that lead to spontaneous colitis when knocked-out in mice. In addition, we sequenced the promoter regions of 45 genes where known variants exert cis-eQTL-effects. Targeted pooled re-sequencing was performed on DNA of 790 Dutch UC cases. The Genome of the Netherlands project provided sequence data of 500 healthy controls. After quality control and prioritization based on allele frequency and pathogenicity probability, follow-up genotyping of 171 rare variants was performed on 1021 Dutch UC cases and 1166 Dutch controls. Single-variant association and gene-based analyses identified an association of rare variants in the MUC2 gene with UC. The associated variants in the Dutch population could not be replicated in a German replication cohort (1026 UC cases, 3532 controls). In conclusion, this study has identified a putative role for MUC2 on UC susceptibility in the Dutch population and suggests a population-specific contribution of rare variants to UC.

Reduced risk of UC in families affected by appendicitis: a Danish national cohort study.

PubMed

Nyboe Andersen, Nynne; Gørtz, Sanne; Frisch, Morten; Jess, Tine

2017-08-01

The possible aetiological link between appendicitis and UC remains unclear. In order to investigate the hereditary component of the association, we studied the risk of UC in family members of individuals with appendicitis. A cohort of 7.1 million individuals was established by linkage of national registers in Denmark with data on kinship and diagnoses of appendicitis and UC. Poisson regression models were used to calculate first hospital contact rate ratios (RR) for UC with 95% CIs between individuals with or without relatives with a history of appendicitis. During 174 million person-years of follow-up between 1977 and 2011, a total of 190 004 cohort members developed appendicitis and 45 202 developed UC. Individuals having a first-degree relative with appendicitis before age 20 years had significantly reduced risk of UC (RR 0.90; 95% CI 0.86 to 0.95); this association was stronger in individuals with a family predisposition to UC (RR 0.66; 95% CI 0.51 to 0.83). Individuals with a first-degree relative diagnosed with appendicitis before age 20 years are at reduced risk of UC, particularly when there is a family predisposition to UC. Our findings question a previously hypothesised direct protective influence of appendicitis on inflammation of the large bowel. Rather, genetic or environmental factors linked to an increased risk of appendicitis while being protective against UC may explain the repeatedly reported reduced relative risk of UC in individuals with a history of appendicitis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs.

PubMed

Deparle, L A; Gupta, R C; Canerdy, T D; Goad, J T; D'Altilio, M; Bagchi, M; Bagchi, D

2005-08-01

DeParle L. A., Gupta R. C., Canerdy T. D., Goad J. T., D'Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J. vet. Pharmacol. Therap.28, 385-390. In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs. Fifteen dogs in three groups received either no UC-II (Group I) or UC-II with 1 mg/day (Group II) or 10 mg/day (Group III) for 90 days. Lameness and pain were measured on a weekly basis for 120 days (90 days treatment plus 30 days post-treatment). Blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury). Dogs receiving 1 mg or 10 mg UC-II/day for 90 days showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion, with 10 mg showed greater improvement. At either dose of UC-II, no adverse effects were noted and no significant changes were noted in serum chemistry, suggesting that UC-II was well tolerated. In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following UC-II withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation. These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.

Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Yong; Dalal, Sushila; Antonopoulos, Dionysios

Background: Ulcerative colitis (UC) only involves the colonic mucosa. Yet, nearly 50% of patients with UC who undergo total proctocolectomy with ileal pouch anal anastomosis develop UC-like inflammation of the ileal pouch (pouchitis). By contrast, patients with familial adenomatous polyposis (FAP) with ileal pouch anal anastomosis develop pouchitis far less frequently. We hypothesized that pathogenic events associated with the development of UC are recapitulated by colonic-metaplastic transcriptomic reprogramming of the UC pouch. Methods: We prospectively sampled pouch and prepouch ileum mucosal biopsies in patients with UC with ileal pouch anal anastomosis 4, 8, and 12 months after their pouch wasmore » in continuity. Mucosal samples were also obtained from patients with FAP. Transcriptional profiles of the UC and FAP pouch and prepouch ileum were investigated via RNA sequencing and compared with data from a previously published microarray study. Results: Unlike patients with FAP, subjects with UC exhibited a large set of differentially expressed genes between the pouch and prepouch ileum as early as 4 months after pouch functionalization. Functional pathway analysis of differentially expressed genes in the UC pouch revealed an enhanced state of immune/inflammatory response and extracellular matrix remodeling. Moreover, >70% of differentially expressed genes mapped to published inflammatory bowel diseases microarray data sets displayed directional changes consistent with active UC but not with Crohn's disease. Conclusions: The UC pouch, well before histologic inflammation, already displays a systems-level gain of colon-associated genes and loss of ileum-associated genes. Patients with UC exhibit a unique transcriptomic response to ileal pouch creation that can be observed well before disease and may in part explain their susceptibility to the development of pouchitis.« less

Berkeley Lab - Lawrence Berkeley National Laboratory

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nanoparticles that could make solar panels more efficient by converting light usually missed by solar cells into of Methane's Increasing Greenhouse Effect A Berkeley Lab research team tracked a rise in the warming effect of methane - one of the most important greenhouse gases for the Earth's atmosphere - over a 10

A-Z Link

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Index (this page) 2. Use search.lbl.gov powered by Google. 3. Use DS The Directory of both People and Berkeley Lab Lawrence Berkeley National Laboratory A-Z Index Directory Submit Web People Navigation Berkeley Lab Search Submit Web People Close About the Lab Leadership/Organization Calendar News Center

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Synthesis Condensed Matter and Materials Physics Scattering and Instrumentation Science Centers Center for materials and phenomena at multiple time and length scales. Through our core programs and research centers Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Search MSD Go MSD - Materials

City of Berkeley, California Municipal Tree Resource Analysis

Treesearch

S.E. Maco; E.G. McPherson; J.R. Simpson; P.J. Peper; Q. Xiao

2005-01-01

Vibrant, renowned for its livability and cultural wealth, the city of Berkeley maintains trees as an integral component of the urban infrastructure. Research indicates that healthy trees can mitigate impacts associated with the built environment by reducing stormwater runoff, energy consumption, and air pollutants. Put simply, trees improve urban life, making Berkeley...

Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap.

PubMed

Terao, Chikashi; Matsumura, Takayoshi; Yoshifuji, Hajime; Kirino, Yohei; Maejima, Yasuhiro; Nakaoka, Yoshikazu; Takahashi, Meiko; Amiya, Eisuke; Tamura, Natsuko; Nakajima, Toshiki; Origuchi, Tomoki; Horita, Tetsuya; Matsukura, Mitsuru; Kochi, Yuta; Ogimoto, Akiyoshi; Yamamoto, Motohisa; Takahashi, Hiroki; Nakayamada, Shingo; Saito, Kazuyoshi; Wada, Yoko; Narita, Ichiei; Kawaguchi, Yasushi; Yamanaka, Hisashi; Ohmura, Koichiro; Atsumi, Tatsuya; Tanemoto, Kazuo; Miyata, Tetsuro; Kuwana, Masataka; Komuro, Issei; Tabara, Yasuharu; Ueda, Atsuhisa; Isobe, Mitsuaki; Mimori, Tsuneyo; Matsuda, Fumihiko

2015-05-01

Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and large branches of the aorta. Ulcerative colitis (UC) is a prevalent autoimmune colitis. Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. We undertook this study to perform a large-scale analysis of TAK, both to evaluate the prevalence of concurrent cases of TAK and UC and to identify and estimate susceptibility genes shared between the 2 diseases. We analyzed a total of 470 consecutive patients with TAK from 14 institutions. We characterized patients with TAK and UC by analyzing clinical manifestations and genetic components. Genetic overlapping of TAK and UC was evaluated with the use of UC susceptibility single-nucleotide polymorphisms by comparing risk directions and effect sizes between susceptibility to the 2 diseases. Thirty of 470 patients with TAK had UC (6.4% [95% confidence interval 4.3-9.0]). This percentage was strikingly higher than that expected from the prevalence of UC in Japan. Patients with TAK complicated with UC developed TAK at an earlier stage of life (P = 0.0070) and showed significant enrichment of HLA-B*52:01 compared to TAK patients without UC (P = 1.0 × 10(-5) ) (odds ratio 12.14 [95% confidence interval 2.96-107.23]). The 110 non-HLA markers of susceptibility to UC significantly displayed common risk directions with susceptibility to TAK (P = 0.0054) and showed significant departure of permutation P values from expected P values (P < 1.0 × 10(-10) ). UC is a major complication of TAK. These 2 diseases share a significant proportion of their genetic background, and HLA-B*52:01 may play a central role in their co-occurrence. © 2015, American College of Rheumatology.

Metallic conductance at the interface of tri-color titanate superlattices

NASA Astrophysics Data System (ADS)

Kareev, M.; Cao, Yanwei; Liu, Xiaoran; Middey, S.; Meyers, D.; Chakhalian, J.

2013-12-01

Ultra-thin tri-color (tri-layer) titanate superlattices ([3 u.c. LaTiO3/2 u.c. SrTiO3/3 u.c. YTiO3], u.c. = unit cells) were grown in a layer-by-layer way on single crystal TbScO3 (110) substrates by pulsed laser deposition. High sample quality and electronic structure were characterized by the combination of in-situ photoelectron and ex-situ structure and surface morphology probes. Temperature-dependent sheet resistance indicates the presence of metallic interfaces in both [3 u.c. LaTiO3/2 u.c. SrTiO3] bi-layers and all the tri-color structures, whereas a [3 u.c. YTiO3/2 u.c. SrTiO3] bi-layer shows insulating behavior. Considering that in the bulk YTiO3 is ferromagnetic below 30 K, the tri-color titanate superlattices provide an opportunity to induce tunable spin-polarization into the two-dimensional electron gas with Mott carriers.

Status of the UC-Berkeley SETI efforts

NASA Astrophysics Data System (ADS)

Korpela, E. J.; Anderson, D. P.; Bankay, R.; Cobb, J.; Howard, A.; Lebofsky, M.; Siemion, A. P. V.; von Korff, J.; Werthimer, D.

2011-10-01

We summarize radio and optical SETI programs based at the University of California, Berkeley. The SEVENDIP optical pulse search looks for ns time scale pulses at visible wavelengths. It utilizes an automated 30 inch telescope, three ultra fast photo multiplier tubes and a coincidence detector. The target list includes F, G, K and M stars, globular cluster and galaxies. The ongoing SERENDIP V.v sky survey searches for radio signals at the 300 meter Arecibo Observatory. The currently installed configuration supports 128 million channels over a 200 MHz bandwidth with ~1.6 Hz spectral resolution. Frequency stepping allows the spectrometer to cover the full 300MHz band of the Arecibo L-band receivers. The final configuration will allow data from all 14 receivers in the Arecibo L-band Focal Array to be monitored simultaneously with over 1.8 billion channels. SETI@home uses the desktop computers of volunteers to analyze over 160 TB of data at taken at Arecibo. Over 6 million volunteers have run SETI@home during its 10 year history. The SETI@home sky survey is 10 times more sensitive than SERENDIP V.v but it covers only a 2.5 MHz band, centered on 1420 MHz. SETI@home searches a much wider parameter space, including 14 octaves of signal bandwidth and 15 octaves of pulse period with Doppler drift corrections from -100 Hz/s to +100 Hz/s. SETI@home is being expanded to analyze data collected during observations of Kepler objects of interest in May 2011. The Astropulse project is the first SETI search for μs time scale pulses in the radio spectrum. Because short pulses are dispersed by the interstellar medium, and the amount of dispersion is unknown, Astropulse must search through 30,000 possible dispersions. Substantial computing power is required to conduct this search, so the project uses volunteers and their personal computers to carry out the computation (using distributed computing similar to SETI@home). Keywords: radio instrumentation, FPGA spectrometers, SETI, optical SETI, Search for Extraterrestrial Intelligence, volunteer computing, radio transients, optical transients.

Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease.

PubMed

de Witte, Samantha F H; Merino, Ana M; Franquesa, Marcella; Strini, Tanja; van Zoggel, Johanna A A; Korevaar, Sander S; Luk, Franka; Gargesha, Madhu; O'Flynn, Lisa; Roy, Debashish; Elliman, Steve J; Newsome, Philip N; Baan, Carla C; Hoogduijn, Martin J

2017-06-08

Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in clinical trials targeting liver diseases; however the efficacy of MSC therapy will benefit from improvement of the immunomodulatory and immunogenic properties of MSC. MSC derived from human umbilical cords (ucMSC) were treated for 3 days in vitro with various inflammatory factors, interleukins, vitamins and serum deprivation. Their immunogenicity and immunomodulatory capacity were examined by gene-expression analysis, surface-marker expressions, IDO activity, PGE 2 secretion and inhibition of T cell proliferation and IFNγ production. Furthermore, their activation of NK cell cytotoxicity was investigated via CD107a expression on NK cells. The immunomodulatory capacity, biodistribution and survival of pre-treated ucMSC were investigated in a CCl 4 -induced liver disease mouse model. In addition, capacity of pre-treated MSC to ameliorate liver inflammation was examined in an ex vivo liver inflammation co-culture model. IFN-γ and a multiple cytokine cocktail (MC) consisting of IFN-γ, TGFβ and retinoic acid upregulated the expression of immunomodulatory factor PD-L1 and IDO activity. Subsequently, both treatments enhanced the capacity of ucMSC to inhibit CD4 and CD8 T cell proliferation and IFN-γ production. The susceptibility of ucMSC for NK cell lysis was decreased by IFN-β, TGFβ and MC treatment. In vivo, no immunomodulation was observed by the ucMSC. Four hours after intravenous infusion in mice with CCl 4 -induced inflammatory liver injury, the majority of ucMSC were trapped in the lungs. Rapid clearance of ucMSC(VitB 6 ), ucMSC(Starv + VitB 6 ) and ucMSC(MC) and altered bio-distribution of ucMSC(TGFβ) compared to untreated ucMSC was observed. In the ex vivo co-culture system with inflammatory liver slices ucMSC(MC) showed significantly enhanced modulatory capacity compared to untreated ucMSC. The present study demonstrates the responsiveness of ucMSC to in vitro optimisation treatment. The observed improvements in immunomodulatory capacity as well as immunogenicity after MC treatment may improve the efficacy of ucMSC as immunotherapy targeted towards liver inflammation.

Gender dimorphism and lack of day/night variation or effects of energy deprivation on undercarboxylated osteocalcin levels in humans.

PubMed

Foo, Joo-Pin; Aronis, Konstantinos N; Chamberland, John P; Thakkar, Bindiya; Hamnvik, Ole-Petter; Brinkoetter, Mary; Zaichenko, Lesya; Mantzoros, Christos S

2013-12-01

Undercarboxylated osteocalcin (ucOC) is a bone marker with potent metabolic effects. Leptin regulates Esp gene expression and osteocalcin carboxylation in animal models. We aim to elucidate day/night patterns of ucOC levels, whether short-term and/or chronic energy deprivation alters ucOC levels, and whether leptin may mediate these changes in humans. Twelve healthy males and females were studied for 72 h in the fed state to study day/night pattern of ucOC. The six female subjects were also studied in a crossover interventional study in the fasting state for 72 h with administration of either placebo or metreleptin in physiological doses. Blood samples were obtained hourly from 0800 a.m. on day 3 until 0800 a.m. on day 4. In a separate study, eleven obese subjects who underwent bariatric surgery were followed for 24 weeks to examine the effects of postsurgery weight loss on ucOC levels. Males have higher ucOC levels compared to females. There is no day/night variation pattern of circulating ucOC in humans. Short-term and chronic energy deprivation or leptin administrations do not alter ucOC levels. The hypothesis that ucOC plays a role in energy homeostasis or of leptin in regulating ucOC in humans is not supported. Copyright © 2013 The Obesity Society.

Tn4556, a 6.8-kilobase-pair transposable element of Streptomyces fradiae.

PubMed Central

Chung, S T

1987-01-01

A 6.8-kilobase-pair (kbp) transposable element (Tn4556) was found in a neomycin-producing strain of Streptomyces fradiae. This element was first observed in two 30.3-kbp plasmids (pUC1123 and pUC1124) which arose when a thiostrepton resistance gene (1 kbp) was ligated with the BclI-2 fragment (22.5 kbp) that contains the origin of replication of phage SF1. The Tn4556 segment was deleted when these plasmids were transduced into another S. fradiae host with phage SF1. These deletion plasmids (pUC1210 and pUC1211) had copy numbers of less than 1 per chromosome and were unstable. In contrast, pUC1123 and pUC1124, with copy numbers of 12 to 15 per chromosome, respectively, were relatively stable. When pUC1210 and pUC1211 were reintroduced into S. fradiae by protoplast transformation, the Tn4556 element transposed again to the plasmids at numerous new locations in either of two orientations. A copy of Tn4556 was found in the S. fradiae chromosome by hybridization studies. It appears that Tn4556 originated from the chromosome, transposed into unstable pUC1210 and pUC1211, and made stable plasmids. A temperature-sensitive hybrid plasmid carrying a viomycin resistance derivative of Tn4556 (pMT660::Tn4556::vph) was constructed. When Streptomyces lividans UC8390 containing the hybrid plasmid was grown at 39 degrees C, Tn4556::vph (Tn4560) transposed to random positions in the host chromosome. Images PMID:2820925

Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis.

PubMed

Hamanaka, Shinsaku; Nakagawa, Tomoo; Hiwasa, Takaki; Ohta, Yuki; Kasamatsu, Shingo; Ishigami, Hideaki; Taida, Takashi; Okimoto, Kenichiro; Saito, Keiko; Maruoka, Daisuke; Matsumura, Tomoaki; Takizawa, Hirotaka; Kashiwado, Koichi; Kobayashi, Sohei; Matsushita, Kazuyuki; Matsubara, Hisahiro; Katsuno, Tatsuro; Arai, Makoto; Kato, Naoya

2018-06-05

The clinical course of ulcerative colitis (UC) is characterized by repeated episodes of relapse and remission. We hypothesized that biomarkers that help distinguish refractory UC patients who are in remission using strong anti-immunotherapy could contribute in preventing the overuse of corticosteroids for treatment. Here we clarified novel autoantibodies for UC patients in remission as clinical indicators to distinguish between refractory and non-refractory UC. Antigen proteins recognized by serum antibodies of patients with UC in remission were screened using the protein array method. To validate the results, AlphaLISA was used to analyze the serum antibody titers with candidate protein antigens. Serum samples from 101 healthy controls, 121 patients with UC, and 39 patients with Crohn's disease were analyzed. Of 66 candidate protein antigens screened by ProtoArray™, 6 were selected for this study. The serum titers of anti-poly ADP-ribose glycohydrolase (PARG), anti-transcription elongation factor A protein-like 1 (TCEAL1), and anti-proline-rich 13 (PRR13) antibodies were significantly higher in patients with UC than in healthy controls. Anti-PARG and anti-PRR13 antibody titers were significantly higher in patients with refractory UC than in patients with non-refractory UC. There were no significant differences in any antibody titer between the active and remission phases. The serum titers of anti-PARG, anti-TCEAL1, and anti-PRR13 antibodies were elevated in patients with UC. Anti-PARG and anti-PRR13 antibody titers may be novel clinical indicators for detecting refractory UC in patients in remission. This article is protected by copyright. All rights reserved.

Prevention of urinary tract infections in palliative radiation for vertebral metastasis and spinal compression: A pilot study in 71 patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manas, Ana; Glaria, Luis; Pena, Carmen

2006-03-01

Purpose: To assess the impact of bladder instillations of hyaluronic acid (HA) on the prevalence of urinary tract infection (UTI) in patients receiving emergency radiotherapy for metastatic spinal cord compression. Methods and Materials: Patients were recruited consecutively at one center and assigned to usual care (UC) (n = 34, mean age 62.2 years) or UC with once-weekly HA instillation (UC + HA) (Cystistat: 40 mg in 50 mL phosphate-buffered saline) (n = 37; mean age, 63.1 years). All patients had an indwelling catheter and received radiotherapy. UTI status was assessed at baseline and during hospitalization. Results: At baseline, patient groupsmore » were comparable, except for the prevalence of UTI at baseline, which was 11.8% and 0% in the UC and UC + HA patients, respectively (p = 0.0477). During hospitalization, 76.5% (vs. 11.8% at baseline, p < 0.0001) of the UC patients had a UTI compared with 13.5% (vs. 0% at baseline, p = 0.0541) of the UC + HA patients (p < 0.0001). Both groups were hospitalized for similar periods (19.8 days [UC] vs. 18.5 days, p = 0.4769) and received equivalent radiotherapy sessions (4.6 [UC] vs. 5.8 sessions, p = 0.2368). Conclusions: Patients receiving UC + HA had a 5.7-fold decrease in UTI prevalence over the hospitalization period compared to UC patients, suggesting that bladder instillations of HA effectively prevent UTI in patients with indwelling catheters receiving radiotherapy for nerve compression.« less

PREFACE: International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011)

NASA Astrophysics Data System (ADS)

Oberauer, Lothar; Raffelt, Georg; Wagner, Robert

2012-07-01

The 12th edition of the International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011) was held 5-9 September 2011 in Munich (and for the first time in Germany). It was organized by the Max Planck Institute for Physics (MPP), the Technical University Munich (TUM) and the Cluster of Excellence 'Origin and Structure of the Universe'. The conference was held in the 'Künstlerhaus', a traditional downtown location for artistic festivities. The meeting attracted 317 participants (61 of which were women) from 29 countries, see figure below. The topics covered by the meeting were Cosmology and particle physics, Dark matter and its detection, Neutrino physics and astrophysics, Gravitational waves and High-energy astrophysics and cosmic rays, and the various interfaces between these areas. The scientific sessions consisted of five mornings of plenary talks, four afternoons of parallel sessions, and an evening poster session. The co-founder of the conference series, Alessandro Bottino, has decided to retire from the position of chairman of the TAUP Steering Committee after the completion of TAUP 2011. On behalf of all followers of this series, we thank him for having started these inspiring events and his many years of dedicated service. We thank all speakers, conveners and participants as well as the members of the organizing, steering and international advisory committee for making this a successful and memorable meeting. Lothar Oberauer, Georg Raffelt, Robert Wagner Proceedings editors Figure Committees International Advisory Committee G AntonUniversity of Erlangen E AprileColumbia University M Baldo-CeolinUniversity of Padova R BattistonUniversity of Perugia & INFN L BergströmUniversity Stockholm R BernabeiUniversity of Rome 'Tor Vergata' A BettiniLSC Canfranc P BinetruyAPC Paris J BlümerKarlsruhe Institute of Technology B CabreraStanford University A CaldwellMax Planck Institute for Physics M ChenQueens University E CocciaUniversity of Rome 'Tor Vergata' K DanzmannMax Planck Institute for Gravitational Physics S DodelsonFermilab G DomogatskyINR Moscow E FioriniUniversità di Milano Bicocca & INFN K FreeseUniversity of Michigan M FukugitaICRR Tokyo T GaisserUniversity of Delaware G GerbierCEA Saclay F HalzenUniversity of Wisconsin W HaxtonLNBL & UC Berkeley J HoughGlasgow University E KomatsuUniversity of Texas E KatsavounidisMassachusetts Institute of Technology M LindnerMax Planck Institute for Nuclear Physics K LeskoLBNL & UC Berkeley A McDonaldQueens University & SNO Laboratory H MurayamaIPMU Tokyo & UC Berkeley A OlintoUniversity of Chicago L ResvanisUniversity of Athens A RubbiaETH Zurich S SarkarUniversity of Oxford A SmirnovICTP Trieste N SmithSNO Laboratory C SpieringDESY Zeuthen N SpoonerUniversity of Sheffield Y SuzukiICRR Tokyo M TeshimaMax Planck Institute for Physics J W F ValleIFIC & University of Valencia L VotanoLNGS E WaxmanWeizmann Institute J WilkersonUniversity of North Carolina TAUP Steering Committee F T AvignoneUniversity of South Carolina B C BarishCaltech E BellottiUniversity of Milan Bicoccia & INFN J BernabeuUniversity of Valencia A BottinoUniversity of Turin & INFN (chair) N FornengoUniversity of Turin & INFN T KajitaICRR Tokyo C W KimJohns Hopkins University & KIAS V MatveevINR Moscow G RaffeltMax Planck Institute for Physics D SinclairUniversity of Carleton M SpiroCEA Saclay Parallel Session Conveners Dark Matter - Candidates and Searches J-C LanfranchiTechnische Universität München T Marrodán UndagoitiaUniversity of Zurich T BringmannUniversität Hamburg Cosmology J WellerLudwig-Maximilians-Universität München S HannestadUniversity of Aarhus Double Beta Decay, Neutrino Mass M HirschIFIC/CSIC - University of Valencia A GiulianiCNRS Orsay Neutrino Oscillations T LachenmaierUniversität Tübingen F SuekaneTohoku University Low-Energy Neutrinos (Geo, Solar, Supernova) A DigheTIFR Mumbai M ChenQueen's University M WurmUniversität Hamburg Gravitational Waves E CocciaUniversity of Rome Tor Vergata and INFN S MarkaColumbia University Astrophysical Messengers (Neutrinos, Gamma-Rays, Cosmic Rays) R M WagnerMax-Planck-Institut für Physik M KachelriessUniversity of Trondheim M KowalskiUniversity of Bonn Organizing Committee N FornengoTorino University and INFN B MajorovitsMax-Planck-Institut für Physik L OberauerTechnische Universität M ü nchen (co-chair) G RaffeltMax-Planck-Institut für Physik (co-chair) S RodríguezMax-Planck-Institut für Physik (conference secretary) S SchönertTechnische Universität München D SinclairSNO Laboratory & Carleton University R M WagnerMax-Planck-Institut für Physik (scientific secretary) B WankerlExcellence Cluster 'Origin and Structure of the Universe' M WurmTechnische Universität München S ZollingerMax-Planck-Institut für Physik Conference photograph

PUB-3000 | BERKELEY LAB HEALTH AND SAFETY MANUAL

Science.gov Websites

ES&H MANUAL (PUB-3000) Berkeley Lab Table of Contents Guide to Using the ES&H Manual Responsible Authors Log of ES&H Manual Changes Requesting a Change to the ES&H Manual Search the ES &H Manual Questions & Comments Lawrence Berkeley National Laboratory University of California

Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study.

PubMed

Silver, Lynn D; Ng, Shu Wen; Ryan-Ibarra, Suzanne; Taillie, Lindsey Smith; Induni, Marta; Miles, Donna R; Poti, Jennifer M; Popkin, Barry M

2017-04-01

Taxes on sugar-sweetened beverages (SSBs) meant to improve health and raise revenue are being adopted, yet evaluation is scarce. This study examines the association of the first penny per ounce SSB excise tax in the United States, in Berkeley, California, with beverage prices, sales, store revenue/consumer spending, and usual beverage intake. Methods included comparison of pre-taxation (before 1 January 2015) and first-year post-taxation (1 March 2015-29 February 2016) measures of (1) beverage prices at 26 Berkeley stores; (2) point-of-sale scanner data on 15.5 million checkouts for beverage prices, sales, and store revenue for two supermarket chains covering three Berkeley and six control non-Berkeley large supermarkets in adjacent cities; and (3) a representative telephone survey (17.4% cooperation rate) of 957 adult Berkeley residents. Key hypotheses were that (1) the tax would be passed through to the prices of taxed beverages among the chain stores in which Berkeley implemented the tax in 2015; (2) sales of taxed beverages would decline, and sales of untaxed beverages would rise, in Berkeley stores more than in comparison non-Berkeley stores; (3) consumer spending per transaction (checkout episode) would not increase in Berkeley stores; and (4) self-reported consumption of taxed beverages would decline. Main outcomes and measures included changes in inflation-adjusted prices (cents/ounce), beverage sales (ounces), consumers' spending measured as store revenue (inflation-adjusted dollars per transaction) in two large chains, and usual beverage intake (grams/day and kilocalories/day). Tax pass-through (changes in the price after imposition of the tax) for SSBs varied in degree and timing by store type and beverage type. Pass-through was complete in large chain supermarkets (+1.07¢/oz, p = 0.001) and small chain supermarkets and chain gas stations (1.31¢/oz, p = 0.004), partial in pharmacies (+0.45¢/oz, p = 0.03), and negative in independent corner stores and independent gas stations (-0.64¢/oz, p = 0.004). Sales-unweighted mean price change from scanner data was +0.67¢/oz (p = 0.00) (sales-weighted, +0.65¢/oz, p = 0.003), with +1.09¢/oz (p < 0.001) for sodas and energy drinks, but a lower change in other categories. Post-tax year 1 scanner data SSB sales (ounces/transaction) in Berkeley stores declined 9.6% (p < 0.001) compared to estimates if the tax were not in place, but rose 6.9% (p < 0.001) for non-Berkeley stores. Sales of untaxed beverages in Berkeley stores rose by 3.5% versus 0.5% (both p < 0.001) for non-Berkeley stores. Overall beverage sales also rose across stores. In Berkeley, sales of water rose by 15.6% (p < 0.001) (exceeding the decline in SSB sales in ounces); untaxed fruit, vegetable, and tea drinks, by 4.37% (p < 0.001); and plain milk, by 0.63% (p = 0.01). Scanner data mean store revenue/consumer spending (dollars per transaction) fell 18¢ less in Berkeley (-$0.36, p < 0.001) than in comparison stores (-$0.54, p < 0.001). Baseline and post-tax Berkeley SSB sales and usual dietary intake were markedly low compared to national levels (at baseline, National Health and Nutrition Examination Survey SSB intake nationally was 131 kcal/d and in Berkeley was 45 kcal/d). Reductions in self-reported mean daily SSB intake in grams (-19.8%, p = 0.49) and in mean per capita SSB caloric intake (-13.3%, p = 0.56) from baseline to post-tax were not statistically significant. Limitations of the study include inability to establish causal links due to observational design, and the absence of health outcomes. Analysis of consumption was limited by the small effect size in relation to high standard error and Berkeley's low baseline consumption. One year following implementation of the nation's first large SSB tax, prices of SSBs increased in many, but not all, settings, SSB sales declined, and sales of untaxed beverages (especially water) and overall study beverages rose in Berkeley; overall consumer spending per transaction in the stores studied did not rise. Price increases for SSBs in two distinct data sources, their timing, and the patterns of change in taxed and untaxed beverage sales suggest that the observed changes may be attributable to the tax. Post-tax self-reported SSB intake did not change significantly compared to baseline. Significant declines in SSB sales, even in this relatively affluent community, accompanied by revenue used for prevention suggest promise for this policy. Evaluation of taxation in jurisdictions with more typical SSB consumption, with controls, is needed to assess broader dietary and potential health impacts.

Preventing Overweight in USAF Personnel: Minimal Contract Program

DTIC Science & Technology

2005-05-01

Allowable Weight (MAW) and heavier. Effectiveness of MCBT + UC is compared to UC in terms of weight loss . Outcomes are being measured at 6 and 12 months...while those assigned to UC actually gained weight . Also, greater fise of the treatment website was associated with significantly more weight loss over...Effectiveness of MCBT + UC will be compared to UC in terms of weight loss . Outcomes are measured at 6 and 12 months. The ultimate goal of this study is to

Laboratory Directed Research and Development Program FY 2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen

2007-03-08

The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operatemore » unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness.« less

Polarization-dependent extraordinary optical transmission from upconversion nanoparticles.

PubMed

Wang, Peng Hui; Salcedo, Walter J; Pichaandi, Jothirmayanantham; van Veggel, Frank C J M; Brolo, Alexandre G

2015-11-21

Enhanced upconversion (UC) emission was experimentally demonstrated using gold double antenna nanoparticles coupled to nanoslits in gold films. The transmitted red emission from UC ytterbium and erbium co-doped sodium yttrium fluoride (NaYF4:Yb(3+)/Er(3+)) nanoparticles (UC NPs) at ∼665 nm (excited with a 980 nm diode laser) was enhanced relative to the green emission at ∼550 nm. The relatively enhanced UC NP emission could be tuned by the different polarization-dependent extraordinary optical transmission modes coupled to the gold nanostructures. Finite-difference time-domain calculations suggest that the preferential enhanced UC emission is related to a combination of different surface plasmon mode excitation coupling to cavity Fabry-Perot interactions. A maximum UC enhancement of 6-fold was measured for nanoslit arrays in the absence of the double antennas. In the presence of the double nanoantennas inside the nanoslits, the UC enhancement was between 2- and 4-fold, depending on the experimental conditions.

Approach to cytomegalovirus infections in patients with ulcerative colitis

PubMed Central

Park, Sung Chul; Jeen, Yoon Mi; Jeen, Yoon Tae

2017-01-01

Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC), and may ref lect exacerbation of mucosal inf lammation and/or administration of immunosuppressants. The question of whether CMV is an active pathogen or ‘an innocent bystander’ in the exacerbation of UC remains controversial. Patients with UC exacerbated by reactivated CMV experience worse prognoses than those without CMV reactivation and antiviral therapy significantly reduces the need for colectomy in patients with severe UC and high-grade CMV infection, indicating that CMV plays a role in UC prognosis. Therefore, the CMV status of patients on immunosuppressants, particularly those with steroid-refractory or -dependent UC, should be tested. When CMV is detected, be performed based on should adequate treatment the extent of the viral load and the presence of certain clinical features including a large ulcer. Anti-tumor necrosis factor agents may be useful for treating CMV colitis complicating UC. PMID:28490715

The UAS control segment architecture: an overview

NASA Astrophysics Data System (ADS)

Gregory, Douglas A.; Batavia, Parag; Coats, Mark; Allport, Chris; Jennings, Ann; Ernst, Richard

2013-05-01

The Under Secretary of Defense (Acquisition, Technology and Logistics) directed the Services in 2009 to jointly develop and demonstrate a common architecture for command and control of Department of Defense (DoD) Unmanned Aircraft Systems (UAS) Groups 2 through 5. The UAS Control Segment (UCS) Architecture is an architecture framework for specifying and designing the softwareintensive capabilities of current and emerging UCS systems in the DoD inventory. The UCS Architecture is based on Service Oriented Architecture (SOA) principles that will be adopted by each of the Services as a common basis for acquiring, integrating, and extending the capabilities of the UAS Control Segment. The UAS Task Force established the UCS Working Group to develop and support the UCS Architecture. The Working Group currently has over three hundred members, and is open to qualified representatives from DoD-approved defense contractors, academia, and the Government. The UCS Architecture is currently at Release 2.2, with Release 3.0 planned for July 2013. This paper discusses the current and planned elements of the UCS Architecture, and related activities of the UCS Community of Interest.

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

PubMed

Cranenburg, Ellen C M; Brandenburg, Vincent M; Vermeer, Cees; Stenger, Melanie; Mühlenbruch, Georg; Mahnken, Andreas H; Gladziwa, Ulrich; Ketteler, Markus; Schurgers, Leon J

2009-02-01

Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a potent local inhibitor of cardiovascular calcification and accumulates at areas of calcification in its uncarboxylated form (ucMGP). We previously found significantly lower circulating ucMGP levels in patients with a high vascular calcification burden. Here we report on the potential of circulating ucMGP to serve as a biomarker for vascular calcification in haemodialysis (HD) patients. Circulating ucMGP levels were measured with an ELISA-based assay in 40 HD patients who underwent multi-slice computed tomography (MSCT) scanning to quantify the extent of coronary artery calcification (CAC). The mean ucMGP level in HD patients (193 +/- 65 nM) was significantly lower as compared to apparently healthy subjects of the same age (441 +/- 97 nM; p < 0.001) and patients with rheumatoid arthritis (RA) without CAC (560 +/- 140 nM; p < 0.001). Additionally, ucMGP levels correlated inversely with CAC scores (r = -0.41; p = 0.009), and this correlation persisted after adjustment for age, dialysis vintage and high-sensitivity C-reactive protein (hs-CRP). Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification.

Desmocollin 2 is a new immunohistochemical marker indicative of squamous differentiation in urothelial carcinoma.

PubMed

Hayashi, Tetsutaro; Sentani, Kazuhiro; Oue, Naohide; Anami, Katsuhiro; Sakamoto, Naoya; Ohara, Shinya; Teishima, Jun; Noguchi, Tsuyoshi; Nakayama, Hirofumi; Taniyama, Kiyomi; Matsubara, Akio; Yasui, Wataru

2011-10-01

Urothelial carcinoma (UC) with squamous differentiation tends to present at higher stages than pure UC. To distinguish UC with squamous differentiation from pure UC, a sensitive and specific marker is needed. Desmocollin 2 (DSC2) is a protein localized in desmosomal junctions of stratified epithelium, but little is known about its biological significance in bladder cancer. We examined the utility of DSC2 as a diagnostic marker. We analysed the immunohistochemical characteristics of DSC2, and studied the relationship of DSC2 expression with the expression of the known markers uroplakin III (UPIII), cytokeratin (CK)7, CK20, epidermal growth factor receptor (EGFR), and p53. DSC2 staining was detected in 24 of 25 (96%) cases of UC with squamous differentiation, but in none of 85 (0%) cases of pure UC. DSC2 staining was detected only in areas of squamous differentiation. DSC2 expression was mutually exclusive of UPIII expression, and was correlated with EGFR expression. Furthermore, DSC2 expression was correlated with higher stage (P = 0.0314) and poor prognosis (P = 0.0477). DSC2 staining offers high sensitivity (96%) and high specificity (100%) for the detection of squamous differentiation in UC. DSC2 is a useful immunohistochemical marker for separation of UC with squamous differentiation from pure UC. 2011 Blackwell Publishing Limited.

Comparison of particle morphology between commercial- and research-grade calcium hydroxide in endodontics.

PubMed

Komabayashi, Takashi; Ahn, Chul; Spears, Robert; Zhu, Qiang

2014-09-01

Ca(OH)2 aqueous slurry is widely used as an inter-appointment antimicrobial dressing in root canal treatment. The aim of this study was to quantify the particle size and shape of commercial-grade UltraCal XS (UC) and to compare it with that of research-grade Ca(OH)2 (RG) using a flow particle image analyzer (FPIA). The morphology and penetration inside the dentin tubules of the UC and RG particles were examined using a scanning electron microscope (SEM). UC and RG (10 mg) were mixed with 15 mL of alcohol, and were sonicated. Five milliliters of the dispersion was subjected to FPIA, and particle length, width, perimeter and aspect ratio were analyzed. In addition, UC paste and RG aqueous slurry were agitated on dentin discs and were prepared for SEM examination. There were significant differences between UC and RG with regard to the frequency of different length groups (P < 0.0001). UC contained smaller particles than RG (P < 0.0001). Under SEM, the agitated UC and RG particles occluded the opening of dentin tubules and penetrated inside the dentin tubules. The size of UC particles is smaller than those of RG. Both UC and RG particles were able to penetrate into open dentin tubules.

Comparison of particle morphology between commercial- and research-grade calcium hydroxide in endodontics

PubMed Central

Komabayashi, Takashi; Ahn, Chul; Spears, Robert; Zhu, Qiang

2014-01-01

Ca(OH)2 aqueous slurry is widely used as an inter-appointment antimicrobial dressing in root canal treatment. The aim of this study was to quantify the particle size and shape of commercial-grade UltraCal XS (UC) and to compare it with that of research-grade Ca(OH)2 (RG) using a flow particle image analyzer (FPIA). The morphology and penetration inside the dentin tubules of the UC and RG particles were examined using a scanning electron microscope (SEM). UC and RG (10 mg) were mixed with 15 mL of alcohol, and were sonicated. Five milliliters of the dispersion was subjected to FPIA, and particle length, width, perimeter and aspect ratio were analyzed. In addition, UC paste and RG aqueous slurry were agitated on dentin discs and were prepared for SEM examination. There were significant differences between UC and RG with regard to the frequency of different length groups (P < 0.0001). UC contained smaller particles than RG (P < 0.0001). Under SEM, the agitated UC and RG particles occluded the opening of dentin tubules and penetrated inside the dentin tubules. The size of UC particles is smaller than those of RG. Both UC and RG particles were able to penetrate into open dentin tubules. PMID:25231145

A prospective audit on the effect of training and educational workshops on the incidence of urethral catheterization injuries

PubMed Central

Bhatt, Nikita R.; Davis, Niall F.; Quinlan, Mark R.; Flynn, Robert J.; McDermott, T.E.D.; Manecksha, Rustom P.; Thornhill, John A.

2017-01-01

Introduction The incidence of iatrogenic urethral catheterization (UC) injuries is approximately 0.3%. Resultant complications are associated with patient morbidity and unnecessary healthcare costs. Our aim was to investigate whether educational training workshops decreased the incidence of UC-related injuries. Methods A prospective audit was performed to calculate incidence, morbidity, and costs associated with iatrogenic UC injury from January to July 2015. Educational workshops were then conducted with healthcare staff and training modules for junior doctors. UC-related incidence, morbidity, and costs in the subsequent six-month period were recorded prospectively and compared with the previous data. Results The incidence of iatrogenic UC injuries was reduced from 4.3/1000 catheters inserted to 3.8/1000 catheters after the intervention (p=0.59). Morbidity from UC increased in the second half in the form of increase in cumulative additional inpatient hospital stay (22 to 79 days; p=0.25), incidence of urosepsis (n=2 to n=4), and need for operative intervention (n=1 to n=2). The cost of managing UC injuries almost doubled in the period after the training intervention (€50 449 to €90 100). Conclusions Current forms of educational and training interventions for UC did not significantly change morbidity or cost of iatrogenic UC injuries despite a decrease in incidence. Improved and intensive training protocols are necessary for UC to prevent avoidable iatrogenic complications, as well as a safer urethral catheter design. PMID:28761592

MiR-29a promotes intestinal epithelial apoptosis in ulcerative colitis by down-regulating Mcl-1.

PubMed

Lv, Bo; Liu, Zhihui; Wang, Shuping; Liu, Fengbin; Yang, Xiaojun; Hou, Jiangtao; Hou, Zhengkun; Chen, Bin

2014-01-01

While it's widely accepted that the etiology of ulcerative colitis (UC) involves both genetic and environmental factors, the pathogenesis of ulcerative colitis is still poorly understood. Intestinal epithelial apoptosis is one of the most common histopathological changes of UC and the expression of a number of apoptosis genes may contribute to the progression of UC. MicroRNAs have recently emerged as powerful regulators of diverse cellular processes and have been shown to be involved in many immune-mediated disorders such as psoriasis, rheumatoid arthritis, lupus, and asthma. A unique microRNA expression profile has been identified in UC, suggesting that, microRNAs play an important role in the pathogenesis of UC. We investigated the role of miR-29a in intestinal epithelial apoptosis in UC. The expression of miR-29a and Mcl-1, an anti-apoptotic BCL-2 family member, was evaluated in both UC patients and UC mice model induced by dextran sodium sulfate (DSS). The apoptosis rate of intestinal epithelial cells was also evaluated. In UC patients and DSS-induced UC in mice, the expression of miR-29a and Mcl-1, were up-regulated and down-regulated, respectively. We identified a miR-29a binding site (7 nucleotides) on the 3'UTR of mcl-1 and mutation in this binding site on the 3'UTR of mcl-1 led to mis-match between miR-29a and mcl-1. Knockout of Mcl-1 caused apoptosis of the colonic epithelial HT29 cells. In addition, miR-29a regulated intestinal epithelial apoptosis by down-regulating the expression of Mcl-1. miR-29a is involved in the pathogenesis of UC by regulating intestinal epithelial apoptosis via Mcl-1.

Expression characteristics of long noncoding RNA uc.322 and its effects on pancreatic islet function.

PubMed

Zhao, Xiaoqin; Rong, Can; Pan, Fenghui; Xiang, Lizhi; Wang, Xinlei; Hu, Yun

2018-06-28

Increasing evidence indicates that long noncoding RNAs (lncRNAs) perform special biological functions by regulating gene expression through multiple pathways and molecular mechanisms. The aim of this study was to explore the expression characteristics of lncRNA uc.322 in pancreatic islet cells and its effects on the secretion function of islet cells. Bioinformatics analysis was used to detect the lncRNA uc.322 sequence, location, and structural features. Expression of lncRNA uc.322 in different tissues was detected by quantitative polymerase chain reaction analyses. Quantitative polymerase chain reaction, Western blot analysis, adenosine triphosphate determination, glucose-stimulated insulin secretion, and enzyme-linked immunosorbent assay were used to evaluate the effects of lncRNA uc.322 on insulin secretion. The results showed that the full-length of lncRNA uc.322 is 224 bp and that it is highly conserved in various species. Bioinformatics analysis revealed that lncRNA uc.322 is located on chr7:122893196-122893419 (GRCH37/hg19) within the SRY-related HMG-box 6 gene exon region. Compared with other tissues, lncRNA uc.322 is highly expressed in pancreatic tissue. Upregulation of lncRNA uc.322 expression increases the insulin transcription factors pancreatic and duodenal homeobox 1 and Forkhead box O1 expression, promotes insulin secretion in the extracellular fluid of Min6 cells, and increases the adenosine triphosphate concentration. On the other hand, knockdown of lncRNA uc.322 has opposite effects on Min6 cells. Overall, this study showed that upregulation of lncRNA uc.322 in islet β-cells can increase the expression of insulin transcription factors and promote insulin secretion, and it may be a new therapeutic target for diabetes. © 2018 Wiley Periodicals, Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Chi-Jung; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Huang, Chao-Yuan

Inter-individual variation in the metabolism of xenobiotics, caused by factors such as cigarette smoking or inorganic arsenic exposure, is hypothesized to be a susceptibility factor for urothelial carcinoma (UC). Therefore, our study aimed to evaluate the role of gene–environment interaction in the carcinogenesis of UC. A hospital-based case–control study was conducted. Urinary arsenic profiles were measured using high-performance liquid chromatography–hydride generator-atomic absorption spectrometry. Genotyping was performed using a polymerase chain reaction-restriction fragment length polymorphism technique. Information about cigarette smoking exposure was acquired from a lifestyle questionnaire. Multivariate logistic regression was applied to estimate the UC risk associated with certain riskmore » factors. We found that UC patients had higher urinary levels of total arsenic, higher percentages of inorganic arsenic (InAs%) and monomethylarsonic acid (MMA%) and lower percentages of dimethylarsinic acid (DMA%) compared to controls. Subjects carrying the GSTM1 null genotype had significantly increased UC risk. However, no association was observed between gene polymorphisms of CYP1A1, EPHX1, SULT1A1 and GSTT1 and UC risk after adjustment for age and sex. Significant gene–environment interactions among urinary arsenic profile, cigarette smoking, and GSTM1 wild/null polymorphism and UC risk were observed after adjustment for potential risk factors. Overall, gene–environment interactions simultaneously played an important role in UC carcinogenesis. In the future, large-scale studies should be conducted using tag-SNPs of xenobiotic-metabolism-related enzymes for gene determination. -- Highlights: ► Subjects with GSTM1 null genotype had significantly increased UC risk. ► UC patients had poor arsenic metabolic ability compared to controls. ► GSTM1 null genotype may modify arsenic related UC risk.« less

Serology of Patients with Ulcerative Colitis After Pouch Surgery Is More Comparable with that of Patients with Crohn's Disease.

PubMed

Goren, Idan; Yahav, Lior; Tulchinsky, Hagit; Dotan, Iris

2015-10-01

The serologic status of patients with ulcerative colitis (UC) who develop postoperative pouchitis was compared with that of patients with Crohn's disease (CD) and unoperated patients with UC. Pouch patients were stratified into normal pouch, acute/recurrent acute pouchitis, and chronic pouchitis/Crohn's-like disease of the pouch groups. Antibodies against glycans associated with CD (anti-Saccharomyces cerevisiae, anti-laminaribioside, anti-chitobioside, and anti-mannobioside carbohydrate antibodies [ASCA, ALCA, ACCA, and AMCA, respectively]) were detected and correlated with type of inflammatory bowel disease and pouch behavior. A total of 501 patients with inflammatory bowel diseases were recruited: 250 (50%) CD, 124 (24.7%) unoperated UC, and 127 (25.3%) UC-pouch. At least 1 positive antibody was detected in 77.6% CD, 52.0% UC-pouch and 33.1% unoperated UC (P < 0.0001 for all). ACCA and AMCA prevalence in CD, UC-pouch and unoperated patients with UC were 33.2%, 24.4%, and 16.9% (P = 0.003 for all) and 35.2%, 26.8%, and 7.3%, respectively (P < 0.0001 for all). ALCA and ASCA were more prevalent in patients with CD than unoperated UC and UC-pouch patients. A longer interval since pouch surgery was associated with inflammatory pouch behavior: 12.45, 11.39, and 8.5 years for acute/recurrent acute pouchitis, chronic pouchitis/Crohn's-like disease of the pouch, and normal pouch, respectively, P = 0.01 for all. The prevalence of the CD-associated anti-glycan antibodies ACCA and AMCA is significantly increased in UC-pouch patients, suggesting that pouch surgery may trigger differential immune responses to glycans. The finding that the serology of UC-pouch patients shares similarities with that of patients with CD supports the notion that those 2 inflammatory bowel diseases share a common pathogenic pathway.

Characterizing Crowd Participation and Productivity of Foldit Through Web Scraping

DTIC Science & Technology

2016-03-01

Berkeley Open Infrastructure for Network Computing CDF Cumulative Distribution Function CPU Central Processing Unit CSSG Crowdsourced Serious Game...computers at once can create a similar capacity. According to Anderson [6], principal investigator for the Berkeley Open Infrastructure for Network...extraterrestrial life. From this project, a software-based distributed computing platform called the Berkeley Open Infrastructure for Network Computing

Participatory Classification in a System for Assessing Multimodal Transportation Patterns

DTIC Science & Technology

2015-02-17

Culler Electrical Engineering and Computer Sciences University of California at Berkeley Technical Report No. UCB/EECS-2015-8 http...California at Berkeley,Electrical Engineering and Computer Sciences,Berkeley,CA,94720 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING...confirmation screen This section sketches the characteristics of the data that was collected, computes the accuracy of the auto- mated inference algorithm

Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.

PubMed

Venkateswaran, Suresh; Prince, Jarod; Cutler, David J; Marigorta, Urko M; Okou, David T; Prahalad, Sampath; Mack, David; Boyle, Brendan; Walters, Thomas; Griffiths, Anne; Sauer, Cary G; LeLeiko, Neal; Keljo, David; Markowitz, James; Baker, Susan S; Rosh, Joel; Pfefferkorn, Marian; Heyman, Melvin B; Patel, Ashish; Otley, Anthony; Baldassano, Robert; Noe, Joshua; Rufo, Paul; Oliva-Hemker, Maria; Davis, Sonia; Zwick, Michael E; Gibson, Greg; Denson, Lee A; Hyams, Jeffrey; Kugathasan, Subra

2018-03-19

The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84-1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59). To study the genetic contribution to exclusive pediatric onset UC, a GWAS was performed on 466 cases with 2099 healthy controls using UK Biobank array. SNP2HLA was used to impute classical HLA alleles and their corresponding amino acids, and the results are compared with adult onset UC. HLA explained the almost entire association signal, dominated with 191 single nucleotide polymorphisms (SNPs) (p = 5 x 10-8 to 5 x 10-10). Although very small effects, established SNPs in adult onset UC loci had similar direction and magnitude in pediatric onset UC. SNP2HLA imputation identified HLA-DRB1*0103 (odds ratio [OR] = 6.941, p = 1.92*10-13) as the most significant association for pediatric UC compared with adult onset UC (OR = 3.59). Further conditioning showed independent effects for HLA-DRB1*1301 (OR = 2.25, p = 7.92*10-9) and another SNP rs17188113 (OR = 0.48, p = 7.56*10-9). Two HLA-DRB1 causal alleles are shared with adult onset UC, while at least 2 signals are unique to pediatric UC. Subsequent stratified analyses indicated that HLA-DRB1*0103 has stronger association for extensive disease (E4: OR = 8.28, p = 4.66x10-10) and female gender (OR = 8.85, p = 4.82x10-13). In pediatric onset UC, the HLA explains almost the entire genetic associations. In addition, the HLA association is approximately twice as strong in pediatric UC compared with adults, due to a combination of novel and shared effects. We speculate the paramount importance of antigenic stimulation either by infectious or noninfectious stimuli as a causal event in pediatric UC onset.

Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice

PubMed Central

Wu, Alex G.; Jaja-Chimedza, Asha; Graf, Brittany L.; Waterman, Carrie; Verzi, Michael P.; Raskin, Ilya

2017-01-01

Moringa (Moringa oleifera Lam.) seed extract (MSE) has anti-inflammatory and antioxidant activities. We investigated the effects of MSE enriched in moringa isothiocyanate-1 (MIC-1), its putative bioactive, on ulcerative colitis (UC) and its anti-inflammatory/antioxidant mechanism likely mediated through Nrf2-signaling pathway. Dextran sulfate sodium (DSS)-induced acute (n = 8/group; 3% DSS for 5 d) and chronic (n = 6/group; cyclic rotations of 2.5% DSS/water for 30 d) UC was induced in mice that were assigned to 4 experimental groups: healthy control (water/vehicle), disease control (DSS/vehicle), MSE treatment (DSS/MSE), or 5-aminosalicyic acid (5-ASA) treatment (positive control; DSS/5-ASA). Following UC induction, water (vehicle), 150 mg/kg MSE, or 50 mg/kg 5-ASA were orally administered for 1 or 2 wks. Disease activity index (DAI), spleen/colon sizes, and colonic histopathology were measured. From colon and/or fecal samples, pro-inflammatory biomarkers, tight-junction proteins, and Nrf2-mediated enzymes were analyzed at protein and/or gene expression levels. Compared to disease control, MSE decreased DAI scores, and showed an increase in colon lengths and decrease in colon weight/length ratios in both UC models. MSE also reduced colonic inflammation/damage and histopathological scores (modestly) in acute UC. MSE decreased colonic secretions of pro-inflammatory keratinocyte-derived cytokine (KC), tumor necrosis factor (TNF)-α, nitric oxide (NO), and myeloperoxidase (MPO) in acute and chronic UC; reduced fecal lipocalin-2 in acute UC; downregulated gene expression of pro-inflammatory interleukin (IL)-1, IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) in acute UC; upregulated expression of claudin-1 and ZO-1 in acute and chronic UC; and upregulated GSTP1, an Nrf2-mediated phase II detoxifying enzyme, in chronic UC. MSE was effective in mitigating UC symptoms and reducing UC-induced colonic pathologies, likely by suppressing pro-inflammatory biomarkers and increasing tight-junction proteins. This effect is consistent with Nrf2-mediated anti-inflammatory/antioxidant signaling pathway documented for other isothiocyanates similar to MIC-1. Therefore, MSE, enriched with MIC-1, may be useful in prevention and treatment of UC. PMID:28922365

Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.

PubMed

Kim, Youjin; Wu, Alex G; Jaja-Chimedza, Asha; Graf, Brittany L; Waterman, Carrie; Verzi, Michael P; Raskin, Ilya

2017-01-01

Moringa (Moringa oleifera Lam.) seed extract (MSE) has anti-inflammatory and antioxidant activities. We investigated the effects of MSE enriched in moringa isothiocyanate-1 (MIC-1), its putative bioactive, on ulcerative colitis (UC) and its anti-inflammatory/antioxidant mechanism likely mediated through Nrf2-signaling pathway. Dextran sulfate sodium (DSS)-induced acute (n = 8/group; 3% DSS for 5 d) and chronic (n = 6/group; cyclic rotations of 2.5% DSS/water for 30 d) UC was induced in mice that were assigned to 4 experimental groups: healthy control (water/vehicle), disease control (DSS/vehicle), MSE treatment (DSS/MSE), or 5-aminosalicyic acid (5-ASA) treatment (positive control; DSS/5-ASA). Following UC induction, water (vehicle), 150 mg/kg MSE, or 50 mg/kg 5-ASA were orally administered for 1 or 2 wks. Disease activity index (DAI), spleen/colon sizes, and colonic histopathology were measured. From colon and/or fecal samples, pro-inflammatory biomarkers, tight-junction proteins, and Nrf2-mediated enzymes were analyzed at protein and/or gene expression levels. Compared to disease control, MSE decreased DAI scores, and showed an increase in colon lengths and decrease in colon weight/length ratios in both UC models. MSE also reduced colonic inflammation/damage and histopathological scores (modestly) in acute UC. MSE decreased colonic secretions of pro-inflammatory keratinocyte-derived cytokine (KC), tumor necrosis factor (TNF)-α, nitric oxide (NO), and myeloperoxidase (MPO) in acute and chronic UC; reduced fecal lipocalin-2 in acute UC; downregulated gene expression of pro-inflammatory interleukin (IL)-1, IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) in acute UC; upregulated expression of claudin-1 and ZO-1 in acute and chronic UC; and upregulated GSTP1, an Nrf2-mediated phase II detoxifying enzyme, in chronic UC. MSE was effective in mitigating UC symptoms and reducing UC-induced colonic pathologies, likely by suppressing pro-inflammatory biomarkers and increasing tight-junction proteins. This effect is consistent with Nrf2-mediated anti-inflammatory/antioxidant signaling pathway documented for other isothiocyanates similar to MIC-1. Therefore, MSE, enriched with MIC-1, may be useful in prevention and treatment of UC.

Site Environmental Report for 2004. Volume 1, Environment, Health, and Safety Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2005-09-30

Each year, Ernest Orlando Lawrence Berkeley National Laboratory prepares an integrated report on its environmental programs to satisfy the requirements of United States Department of Energy Order 231.1A, Environment, Safety, and Health Reporting.1 The Site Environmental Report for 2004 summarizes Berkeley Lab’s environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year 2004. (Throughout this report, Ernest Orlando Lawrence Berkeley National Laboratory is referred to as “Berkeley Lab,” “the Laboratory,” “Lawrence Berkeley National Laboratory,” and “LBNL.”) The report is separated into two volumes. Volume I contains an overview of the Laboratory, the status of environmental programs,more » and summarized results from surveillance and monitoring activities. Volume II contains individual data results from these activities. This year, the Site Environmental Report was distributed by releasing it on the Web from the Berkeley Lab Environmental Services Group (ESG) home page, which is located at http://www.lbl.gov/ehs/esg/. Many of the documents cited in this report also are accessible from the ESG Web page. CD and printed copies of this Site Environmental Report are available upon request.« less

Star Formation near Berkeley 59: Embedded Protostars

NASA Astrophysics Data System (ADS)

Rosvick, J. M.; Majaess, D.

2013-12-01

A group of suspected protostars in a dark cloud northwest of the young (~2 Myr) cluster Berkeley 59 and two sources in a pillar south of the cluster have been studied in order to determine their evolutionary stages and ascertain whether their formation was triggered by Berkeley 59. Narrowband near-infrared observations from the Observatoire du Mont Mégantic, 12CO (J = 3-2) and SCUBA-2 (450 and 850 μm) observations from the JCMT, 2MASS, and WISE images, and data extracted from the IPHAS survey catalog were used. Of 12 sources studied, two are Class I objects, while three others are flat/Class II, one of which is a T Tauri candidate. A weak CO outflow and two potential starless cores are present in the cloud, while the pillar possesses substructure at different velocities, with no outflows present. The CO spectra of both regions show peaks in the range v LSR = -15 to -17 km s-1, which agrees with the velocity adopted for Berkeley 59 (-15.7 km s-1), while spectral energy distribution models yield an average interstellar extinction AV and distance of 15 ± 2 mag and 830 ± 120 pc, respectively, for the cloud, and 6.9 mag and 912 pc for the pillar, indicating that the regions are in the same vicinity as Berkeley 59. The formation of the pillar source appears to have been triggered by Berkeley 59. It is unclear whether Berkeley 59 triggered the association's formation.

Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study

PubMed Central

Ryan-Ibarra, Suzanne; Taillie, Lindsey Smith; Induni, Marta

2017-01-01

Background Taxes on sugar-sweetened beverages (SSBs) meant to improve health and raise revenue are being adopted, yet evaluation is scarce. This study examines the association of the first penny per ounce SSB excise tax in the United States, in Berkeley, California, with beverage prices, sales, store revenue/consumer spending, and usual beverage intake. Methods and findings Methods included comparison of pre-taxation (before 1 January 2015) and first-year post-taxation (1 March 2015–29 February 2016) measures of (1) beverage prices at 26 Berkeley stores; (2) point-of-sale scanner data on 15.5 million checkouts for beverage prices, sales, and store revenue for two supermarket chains covering three Berkeley and six control non-Berkeley large supermarkets in adjacent cities; and (3) a representative telephone survey (17.4% cooperation rate) of 957 adult Berkeley residents. Key hypotheses were that (1) the tax would be passed through to the prices of taxed beverages among the chain stores in which Berkeley implemented the tax in 2015; (2) sales of taxed beverages would decline, and sales of untaxed beverages would rise, in Berkeley stores more than in comparison non-Berkeley stores; (3) consumer spending per transaction (checkout episode) would not increase in Berkeley stores; and (4) self-reported consumption of taxed beverages would decline. Main outcomes and measures included changes in inflation-adjusted prices (cents/ounce), beverage sales (ounces), consumers’ spending measured as store revenue (inflation-adjusted dollars per transaction) in two large chains, and usual beverage intake (grams/day and kilocalories/day). Tax pass-through (changes in the price after imposition of the tax) for SSBs varied in degree and timing by store type and beverage type. Pass-through was complete in large chain supermarkets (+1.07¢/oz, p = 0.001) and small chain supermarkets and chain gas stations (1.31¢/oz, p = 0.004), partial in pharmacies (+0.45¢/oz, p = 0.03), and negative in independent corner stores and independent gas stations (−0.64¢/oz, p = 0.004). Sales-unweighted mean price change from scanner data was +0.67¢/oz (p = 0.00) (sales-weighted, +0.65¢/oz, p = 0.003), with +1.09¢/oz (p < 0.001) for sodas and energy drinks, but a lower change in other categories. Post-tax year 1 scanner data SSB sales (ounces/transaction) in Berkeley stores declined 9.6% (p < 0.001) compared to estimates if the tax were not in place, but rose 6.9% (p < 0.001) for non-Berkeley stores. Sales of untaxed beverages in Berkeley stores rose by 3.5% versus 0.5% (both p < 0.001) for non-Berkeley stores. Overall beverage sales also rose across stores. In Berkeley, sales of water rose by 15.6% (p < 0.001) (exceeding the decline in SSB sales in ounces); untaxed fruit, vegetable, and tea drinks, by 4.37% (p < 0.001); and plain milk, by 0.63% (p = 0.01). Scanner data mean store revenue/consumer spending (dollars per transaction) fell 18¢ less in Berkeley (−$0.36, p < 0.001) than in comparison stores (−$0.54, p < 0.001). Baseline and post-tax Berkeley SSB sales and usual dietary intake were markedly low compared to national levels (at baseline, National Health and Nutrition Examination Survey SSB intake nationally was 131 kcal/d and in Berkeley was 45 kcal/d). Reductions in self-reported mean daily SSB intake in grams (−19.8%, p = 0.49) and in mean per capita SSB caloric intake (−13.3%, p = 0.56) from baseline to post-tax were not statistically significant. Limitations of the study include inability to establish causal links due to observational design, and the absence of health outcomes. Analysis of consumption was limited by the small effect size in relation to high standard error and Berkeley’s low baseline consumption. Conclusions One year following implementation of the nation’s first large SSB tax, prices of SSBs increased in many, but not all, settings, SSB sales declined, and sales of untaxed beverages (especially water) and overall study beverages rose in Berkeley; overall consumer spending per transaction in the stores studied did not rise. Price increases for SSBs in two distinct data sources, their timing, and the patterns of change in taxed and untaxed beverage sales suggest that the observed changes may be attributable to the tax. Post-tax self-reported SSB intake did not change significantly compared to baseline. Significant declines in SSB sales, even in this relatively affluent community, accompanied by revenue used for prevention suggest promise for this policy. Evaluation of taxation in jurisdictions with more typical SSB consumption, with controls, is needed to assess broader dietary and potential health impacts. PMID:28419108

The Berkeley Out-of-Order Machine (BOOM): An Industry-Competitive, Synthesizable, Parameterized RISC-V Processor

DTIC Science & Technology

2015-06-13

The Berkeley Out-of-Order Machine (BOOM): An Industry- Competitive, Synthesizable, Parameterized RISC-V Processor Christopher Celio David A...Synthesizable, Parameterized RISC-V Processor Christopher Celio, David Patterson, and Krste Asanović University of California, Berkeley, California 94720...Order Machine BOOM is a synthesizable, parameterized, superscalar out- of-order RISC-V core designed to serve as the prototypical baseline processor

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Search MSD Go MSD - Materials Investigators Ager, Joel W » Alivisatos, A Paul » Altman, Ehud » Analytis, James » Anderson, Christopher  , Naomi » Gullikson, Eric M » Harris, Stephen J » Hasan, M. Zahid » Hellman, Frances » Helms, Brett A

A Profile of Minority Graduate Students at the University of California, Berkeley: Recruitment, Selection, Fields of Study and Financial Support.

ERIC Educational Resources Information Center

Collins, O. R.

This paper presents a profile of minority graduate students at the University of California, Berkeley. Following a brief overview of Berkeley's Graduate Minority Program (GMP), data is presented concerning the number of GMP students supported; available funds and average grants for students from 1968-69 to 1973-74; distribution of GMP students…

Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans

PubMed Central

Schultz, Douglas H.; Balderston, Nicholas L.; Geiger, Jennifer A.; Helmstetter, Fred J.

2014-01-01

The nature of the relationship between explicit and implicit learning is a topic of considerable debate. In order to investigate this relationship we conducted two experiments on postconditioning revaluation of the unconditional stimulus (UCS) in human fear conditioning. In Experiment 1, the intensity of the UCS was decreased following acquisition for one group (devaluation) and held constant for another group (control). A subsequent test revealed that even though both groups exhibited similar levels of UCS expectancy, the devaluation group had significantly smaller conditional skin conductance responses. The devaluation effect was not explained by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS intensity had changed. In Experiment 2, the value of the UCS was increased following acquisition for one group (inflation) and held constant for another group (control). Test performance revealed that UCS inflation did not alter expectancy ratings, but the inflation group exhibited larger learned skin conductance responses than the control group. The inflation effect was not explained by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS intensity had changed. The SCR revaluation effect was not dependent on explicit memory processes in either experiment. In both experiments we found differences on an implicit measure of learning in the absence of changes in explicit measures. Together, the differences observed between expectancy measures and skin conductance support the idea that these responses might reflect different types of memory formed during the same training procedure and be supported by separate neural systems. PMID:23731073

First-principles study of uranium carbide: Accommodation of point defects and of helium, xenon, and oxygen impurities

NASA Astrophysics Data System (ADS)

Freyss, Michel

2010-01-01

Point defects and volatile impurities (helium, xenon, oxygen) in uranium monocarbide UC are studied by first-principles calculations. Preliminarily, bulk properties of UC and of two other uranium carbide phases, UC2 and U2C3 , are calculated in order to compare them to experimental data and to get confidence in the use of the generalized gradient approximation for this class of compounds. The subsequent study of different types of point defects shows that the carbon sublattice best accommodates the defects. The perturbation of the crystal structure induced by the defects is weak and the interaction between defects is found short range. Interstitial carbon dumbbells possibly play an important role in the diffusion of carbon atoms. The most favorable location of diluted helium, xenon, and oxygen impurities in the UC crystal lattice is then determined. The rare-gas atoms occupy preferably a uranium substitution site or a uranium site in a U-C bivacancy. But their incorporation in UC is, however, not energetically favorable, especially for xenon, suggesting their propensity to diffuse in the material and/or form bubbles. On the other hand, oxygen atoms are very favorably incorporated as diluted atoms in the UC lattice, confirming the easy oxidation of UC. The oxygen atoms preferably occupy a carbon substitution site or the carbon site of a U-C bivacancy. Our results are compared to available experimental data on UC and to similar studies by first-principles calculations for other carbides and nitrides with the rock-salt structure.

Polymorphisms of the IL-1beta and IL-1beta-inducible genes in ulcerative colitis.

PubMed

Nohara, Hiroaki; Saito, Yuki; Higaki, Singo; Okayama, Naoko; Hamanaka, Yuichiro; Okita, Kiwamu; Hinoda, Yuji

2002-11-01

Ulcerative colitis (UC) is a chronic disorder of undetermined etiology, but a genetic predisposition to UC is well recognized. Among cytokines induced in UC, interleukin 1 (IL-1) appears to have a central role because of its immunological upregulatory and proinflammatory activities. The aim of this study was to assess whether UC is associated with polymorphisms of the IL-1beta gene and three additional genes inducible with IL-1beta in Japanese subjects. A total of 96 patients with UC and 106 ethnically matched controls were genotyped at polymorphic sites in IL-1beta, matrix metalloproteinase 1 (MMP-1), matrix metalloproteinase 3 (MMP-3), and inducible nitric oxide synthase (iNOS) genes, using polymerase chain reaction (PCR)-based methods. There was no significant difference in genotype distributions of IL-1beta, MMP-1, MMP-3, and iNOS genes between controls and UC patients in a Japanese population. Also, no significant association of those polymorphisms with various clinical parameters of the patients was found. However, concerning association of age at onset with clinical factors in UC, the frequency of pancolitis was significantly higher in UC patients with age at onset being less than 30 years than in those more than 30 years of age (P = 0.049). No association of the IL-1beta and three IL-1beta-inducible gene polymorphisms with UC was observed in a Japanese population.

Lack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaques.

PubMed

McConville, Christopher; Smith, James M; McCoy, Clare F; Srinivasan, Priya; Mitchell, James; Holder, Angela; Otten, Ron A; Butera, Salvatore; Doncel, Gustavo F; Friend, David R; Malcolm, R Karl

2015-02-01

This study describes the preclinical development of a matrix-type silicone elastomer vaginal ring device designed to provide controlled release of UC781, a non-nucleoside reverse transcriptase inhibitor. Testing of both human- and macaque-sized rings in a sink condition in vitro release model demonstrated continuous UC781 release in quantities considered sufficient to maintain vaginal fluid concentrations at levels 82-860-fold higher than the in vitro IC50 (2.0 to 10.4 nM) and therefore potentially protect against mucosal transmission of HIV. The 100-mg UC781 rings were well tolerated in pig-tailed macaques, did not induce local inflammation as determined by cytokine analysis and maintained median concentrations in vaginal fluids of UC781 in the range of 0.27 to 5.18 mM during the course of the 28-day study. Analysis of residual UC781 content in rings after completion of both the in vitro release and macaque pharmacokinetic studies revealed that 57 and 5 mg of UC781 was released, respectively. The pharmacokinetic analysis of a 100-mg UC781 vaginal ring in pig-tailed macaques showed poor in vivo-in vitro correlation, attributed to the very poor solubility of UC781 in vaginal fluid and resulting in a dissolution-controlled drug release mechanism rather than the expected diffusion-controlled mechanism.

Anti-TNF-A therapy about infliximab and adalimamab for the effectiveness in ulcerative colitis compared with conventional therapy: a meta-analysis.

PubMed

Zhou, Zheng; Dai, Cong; Liu, Wei-Xin

2015-01-01

TNF-α has an important role in the pathogenesis of ulcerative colitis (UC). It seems that anti-TNF-α therapy is beneficial in the treatment of UC. The aim was to assess the effectiveness of Infliximab and Adalimamab with UC compared with conventional therapy. The Pubmed and Embase databases were searched for studies investigating the efficacy of infliximab and adalimumab on UC. Infliximab had a statistically significant effects in induction of clinical response (RR = 1.67; 95% CI 1.12 to 2.50) of UC compared with conventional therapy, but those had not a statistically significant effects in clinical remission (RR = 1.63; 95% CI 0.84 to 3.18) and reduction of colectomy rate (RR = 0.54; 95% CI 0.26 to 1.12) of UC. And adalimumab had a statistically significant effects in induction of clinical remission (RR = 1.82; 95% CI 1.24 to 2.67) and clinical response (RR = 1.36; 95% CI 1.13 to 1.64) of UC compared with conventional therapy. Our meta-analyses suggested that Infliximab had a statistically significant effects in induction of clinical response of UC compared with conventional therapy and adalimumab had a statistically significant effects in induction of clinical remission and clinical response of UC compared with conventional therapy.

Anti-TNF-A Therapy about Infliximab and Adalimamab for the Effectiveness in Ulcerative Colitis Compared with Conventional Therapy: A Meta-Analysis.

PubMed

Zhou, Zheng; Dai, Cong; Liu, Wei-xin

2015-06-01

TNF-α has an important role in the pathogenesis of ulcerative colitis (UC). It seems that anti-TNF-α therapy is beneficial in the treatment of UC. The aim was to assess the effectiveness of Infliximab and Adalimamab with UC compared with con- ventional therapy. The Pubmed and Embase databases were searched for studies investigating the efficacy of infliximab and adalimumab on UC. Infliximab had a statistically significant effects in induction of clinical response (RR = 1.67; 95% CI 1.12 to 2.50) of UC compared with conventional therapy, but those had not a statistically significant effects in clinical remission (RR = 1.63; 95% CI 0.84 to 3.18) and reduction of colectomy rate (RR = 0.54; 95% CI 0.26 to 1.12) of UC. And adalimumab had a statistically significant effects in induction of clinical remission (RR =1.82; 95% CI 1.24 to 2.67) and clinical response (RR =1.36; 95% CI 1.13 to 1.64) of UC compared with conventional therapy. Our meta-analyses suggested that Infliximab had a statistically significant effects in induction of clinical response of UC compared with conventional therapy and adalimumab had a statistically significant effects in induction of clinical remission and clinical response of UC compared with conventional therapy.

MF2KtoMF05UC, a Program To Convert MODFLOW-2000 Files to MODFLOW-2005 and UCODE_2005 Files

USGS Publications Warehouse

Harbaugh, Arlen W.

2007-01-01

The program MF2KtoMF05UC has been developed to convert MODFLOW-2000 input files for use by MODFLOW-2005 and UCODE_2005. MF2KtoMF05UC was written in the Fortran 90 computer language. This report documents the use of MF2KtoMF05UC.

A three-stage birandom program for unit commitment with wind power uncertainty.

PubMed

Zhang, Na; Li, Weidong; Liu, Rao; Lv, Quan; Sun, Liang

2014-01-01

The integration of large-scale wind power adds a significant uncertainty to power system planning and operating. The wind forecast error is decreased with the forecast horizon, particularly when it is from one day to several hours ahead. Integrating intraday unit commitment (UC) adjustment process based on updated ultra-short term wind forecast information is one way to improve the dispatching results. A novel three-stage UC decision method, in which the day-ahead UC decisions are determined in the first stage, the intraday UC adjustment decisions of subfast start units are determined in the second stage, and the UC decisions of fast-start units and dispatching decisions are determined in the third stage is presented. Accordingly, a three-stage birandom UC model is presented, in which the intraday hours-ahead forecasted wind power is formulated as a birandom variable, and the intraday UC adjustment event is formulated as a birandom event. The equilibrium chance constraint is employed to ensure the reliability requirement. A birandom simulation based hybrid genetic algorithm is designed to solve the proposed model. Some computational results indicate that the proposed model provides UC decisions with lower expected total costs.

Golimumab in unresponsive ulcerative colitis.

PubMed

Lippert, Elisabeth; Müller, Martina; Ott, Claudia

2014-01-01

Ulcerative colitis (UC) is a chronic inflammation mainly affecting the colon mucosa. It predominantly occurs in younger patients. Until recently, the main goals in the treatment of UC were to temper the symptoms, such as diarrhea, pain, and weight loss, by using mesalazine and steroids. With newer medications, such as immunomodulators (thiopurines) and the biologics providing blockade of tumor necrosis factor (TNF), the goals of the therapy in UC have changed to long-term remission and mucosal healing. The first available anti-TNF therapy in UC included infusion therapy with infliximab every few weeks. In 2012, subcutaneously administered adalimumab gained approval for the treatment of UC in Germany. In patients with a mild disease, therapy with mesalazine, orally or topically, can be sufficient. In patients with moderate to severe disease, therapy with azathioprine or anti-TNF is often required to reach disease control; however, this is only efficient in about two-thirds of patients. Some patients either show no response or a lost response while on treatment. So, further medical options are warranted in the treatment of UC. With golimumab, a new approach in the treatment of mild to moderate UC recently became available in Germany and is a promising new option in the therapy regimen for patients with UC.

Betaine synthesis in chenopods: localization in chloroplasts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, A.D.; May A.M.; Grumet, R.

1985-06-01

Plants from several families (Chenopodiaceae, Gramineae, Compositae) accumulate betaine (glycine betaine) in response to salt or water stress via the pathway: choline betainal (betaine aldehyde) betaine. Betaine accumulation is probably a metabolic adaptation to stress. Intact protoplasts from leaves of spinach (Spinacia oleracea) oxidized ( UC)choline to betainal and betaine, as did protoplast lysates. Upon differential centrifugation, the ( UC)choline-oxidizing activity of lysates sedimented with chloroplasts. Chloroplasts purified from protoplast lysates by a Percoll cushion procedure retained strong ( UC)choline-oxidizing activity, although the proportion of the intermediate, ( UC)betainal, in the reaction products was usually higher than for protoplasts. Isolatedmore » chloroplasts also readily oxidized ( UC)betainal to betaine. Light increased the oxidation of both ( UC)choline and ( UC)betainal by isolated chloroplasts. Similar results were obtained with another chenopod (Beta vulgaris) but not with pea (Pisum sativum), a species that accumulates no betaine. The chloroplast site for betaine synthesis in chenopods contrasts with the mitochondrial site in mammals.« less

Interleukin 27 is up-regulated in patients with active inflammatory bowel disease.

PubMed

Furuzawa Carballeda, Janette; Fonseca Camarillo, Gabriela; Yamamoto-Furusho, Jesús K

2016-08-01

The aim of the study was to characterize and quantify tissue gene and protein expression of IL-27 in ulcerative colitis (UC) and Crohn's disease (CD) patients. This is an observational and cross-sectional study. Fifty-four patients with IBD were studied: 27 active UC, 12 inactive UC, 10 active CD, and 5 inactive CD. All patients belonged to the Inflammatory Bowel Disease Clinic at the Instituto Nacional de Ciencias Médicas y Nutrición. We found that IL-27 gene expression was significantly higher in active UC versus inactive UC group (P = 0.015). The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease (P = 0.035). The percentage of IL-27 immunoreactive cells was higher in active UC versus active CD patients and non-inflamed tissue controls. The IL-27 was significantly elevated in active UC and CD patients, and it was associated with disease severity.

First Results on High-spin States in ^179Au

NASA Astrophysics Data System (ADS)

Mueller, W. F.; Bingham, C. R.; Reviol, W.; Riedinger, L. L.; Smith, B. H.; Wauters, J.; Ahmad, I.; Amro, H. A.; Blumenthal, D. J.; Carpenter, M. P.; Davids, C. N.; Fischer, S. M.; Hackman, G.; Henderson, D. J.; Janssens, R. V. F.; Khoo, T. L.; Lauritsen, T.; Lister, C. J.; Nisius, D. T.; Seweryniak, D.; Ma, W. C.

1996-05-01

High-spin states in ^179Au were studied for the first time in two experiments at the Argonne uc(atlas) facility. The ^144Sm(^40Ar,p4n)^179Au reaction at 207 MeV was used for the first experiment and ^124Te(^58Ni,p2n)^179Au at 255 MeV in the second. The setup in the first experiment consisted of the Fragment Mass Analyzer (uc(fma)) plus Parallel Plate Avalanche Counter (uc(ppac)) system and 10 Compton-suppressed Ge detectors (CSG's). From this run, several transitions from the yrast bands were established. The latter experiment utilized the uc(fma) + uc(ppac) system in conjunction with the uc(aye-ball) array of 19 Ge detectors (eight >70% efficient CSG's, nine 25% efficient CSG's, and two LEPS; one with Compton suppression) and a double sided silicon strip detector (uc(dssd).) The results from these experiments, including a level scheme, will be presented and discussed.

Site Environmental Report for 2006. Volume I, Environment, Health, and Safety Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2007-09-30

Each year, Ernest Orlando Lawrence Berkeley National Laboratory prepares an integrated report on its environmental programs to satisfy the requirements of United States Department of Energy Order 231.1A, Environment, Safety, and Health Reporting.1 The Site Environmental Report for 2006 summarizes Berkeley Lab’s environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year 2006. (Throughout this report, Ernest Orlando Lawrence Berkeley National Laboratory is referred to as “Berkeley Lab,” “the Laboratory,” “Lawrence Berkeley National Laboratory,” and “LBNL.”) The report is separated into two volumes. Volume I is organized into an executive summary followed by six chapters thatmore » contain an overview of the Laboratory, a discussion of the Laboratory’s environmental management system, the status of environmental programs, and summarized results from surveillance and monitoring activities. Volume II contains individual data results from surveillance and monitoring activities.« less

Laboratory directed research and development program FY 1999

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, Todd; Levy, Karin

2000-03-08

The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operatemore » unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. This is the annual report on Laboratory Directed Research and Development (LDRD) program for FY99.« less

Impact of the Berkeley Excise Tax on Sugar-Sweetened Beverage Consumption

PubMed Central

Falbe, Jennifer; Thompson, Hannah R.; Becker, Christina M.; Rojas, Nadia; McCulloch, Charles E.

2016-01-01

Objectives. To evaluate the impact of the excise tax on sugar-sweetened beverage (SSB) consumption in Berkeley, California, which became the first US jurisdiction to implement such a tax ($0.01/oz) in March 2015. Methods. We used a repeated cross-sectional design to examine changes in pre- to posttax beverage consumption in low-income neighborhoods in Berkeley versus in the comparison cities of Oakland and San Francisco, California. A beverage frequency questionnaire was interviewer administered to 990 participants before the tax and 1689 after the tax (approximately 8 months after the vote and 4 months after implementation) to examine relative changes in consumption. Results. Consumption of SSBs decreased 21% in Berkeley and increased 4% in comparison cities (P = .046). Water consumption increased more in Berkeley (+63%) than in comparison cities (+19%; P < .01). Conclusions. Berkeley’s excise tax reduced SSB consumption in low-income neighborhoods. Evaluating SSB taxes in other cities will improve understanding of their public health benefit and their generalizability. PMID:27552267

Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis

PubMed Central

Nahar, Saifun; Iraha, Atsushi; Hokama, Akira; Uehara, Ayako; Parrott, Gretchen; Ohira, Tetsuya; Kaida, Masatoshi; Kinjo, Tetsu; Kinjo, Takeshi; Hirata, Tetsuo; Kinjo, Nagisa; Fujita, Jiro

2015-01-01

AIM: To evaluate a multiplex PCR assay for the detection of bacterial and viral enteropathogens in stool samples from patients with ulcerative colitis (UC). METHODS: We prospectively analyzed 300 individuals, including immunocompetent patients, immunocompromised patients, and patients with UC. Stool samples were collected from the recto-sigmoid region of the colon by endoscopy. The samples were qualitatively analyzed for bacterial and viral enteropathogens with a multiplex PCR assay using a Seeplex® Kit. Additional clinical and laboratory data were collected from the medical records. RESULTS: A multiplex PCR assay detected 397 pathogens (191 bacteria and 206 viruses) in 215 samples (71.7%). The most frequently detected bacteria were Escherichia coli H7, 85 (28.3%); followed by Aeromonas spp., 43 (14.3%); and Clostridium perfringens, 36 (12.0%) samples. The most prevalent viruses were Epstein-Barr virus (EBV), 90 (30.0%); followed by human herpes virus-6 (HHV-6), 53 (17.7%); and cytomegalovirus (CMV), 37 (12.3%) samples. The prevalence rate of CMV infection was significantly higher in the immunocompromised group than in the immunocompetent group (P < 0.01). CMV infection was more common in patients with UC (26/71; 36.6%) than in the immunocompetent patients excluding UC (6/188; 3.2%) (P < 0.01). CMV infection was more prevalent in UC active patients (25/58; 43.1%) than in UC inactive patients (1/13; 7.7%) (P < 0.05). Among 4 groups which defined by the UC activity and immunosuppressive drugs, the prevalence rate of CMV infection was highest in the UC active patients with immunosuppressive drugs (19/34; 55.8%). Epstein-Barr virus (EBV) infection was more common in the immunocompromised patients excluding UC (18/41; 43.9%) than in the immunocompetent patients excluding UC (47/188; 25.0%) (P < 0.05). The simultaneous presence of CMV and EBV and/or HHV6 in UC active patients (14/58; 24.1%) was greater than in immunocompromised patients excluding UC (5/41; 12.2%) (P < 0.05). CONCLUSION: The multiplex PCR assay that was used to analyze the stool samples in this study may serve as a non-invasive approach that can be used to exclude the possibility of CMV infection in patients with active UC who are treated with immunosuppressive therapy. PMID:26640344

From Relational Interfaces to Assume-Guarantee Contracts

DTIC Science & Technology

2014-03-18

Electrical Engineering and Computer Sciences University of California at Berkeley Technical Report No. UCB/EECS-2014-21 http://www.eecs.berkeley.edu/Pubs...5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of California at Berkeley, Electrical Engineering...design,” in EMSOFT’01. Springer, LNCS 2211, 2001. [2] A. Sangiovanni-Vincentelli et al., “Taming Dr. Frankenstein : Contract-Based Design for Cyber

Stability and adaptability of popcorn genotypes in the State of Rio de Janeiro, Brazil.

PubMed

Pena, G F; do Amaral, A T; Gonçalves, L S A; Candido, L S; Vittorazzi, C; Ribeiro, R M; Freitas, S P

2012-08-31

This study aimed to obtain estimates of stability and adaptability of phase launched materials and materials recommended in the country, for the northern and northwestern regions of Rio de Janeiro State, Brazil, and made a comparative analysis of different methods to evaluate stability and adaptability of grain yield and popping expansion. To this end, 10 genotypes were evaluated (UNB2U-C3, UNB2U-C4, BRS Angela, Viçosa, Beija-Flor, IAC 112, IAC 125, Zélia, Jade, and UFVM2 Barão de Viçosa) in five environments. The Yates and Cochran method revealed that genotypes UFV2M Barão de Viçosa, BRS Angela and UNB2U-C3 were the most stable for grain yield. This method also indicated superiority of genotypes UNB2U-C3, UNB2U-C4, BRS Angela, Viçosa, IAC 125, and Zélia for popping expansion. The Plaisted and Peterson and Wricke methods demonstrated that genotypes Zélia and UNB2U-C4 were the most productive and stable. These methods indicated genotypes UNB2U-C3 and BRS Angela as the most stable for popping expansion. The Kang and Phan ranking system uses methods based on analysis of variance and classified population UNB2U-C4 as the genotype with the highest stability of grain production and confirmed cultivar BRS Angela as the most stable for popping expansion. Genotypes IAC 112 and UNB2U-C4 were the most stable and adapted for grain yield, according to the Lin and Binns method. The P(i) statistics also ranked UNB2U-C3 and UNB2U-C4 as the genotypes with the best predictability and capacity for popping expansion.

Thiopurine Therapy Reduces the Incidence of Colorectal Neoplasia in Patients with Ulcerative Colitis. Data from the ENEIDA Registry.

PubMed

Gordillo, Jordi; Cabré, Eduard; Garcia-Planella, Esther; Ricart, Elena; Ber-Nieto, Yolanda; Márquez, Lucía; Rodríguez-Moranta, Francisco; Ponferrada, Ángel; Vera, Isabel; Gisbert, Javier P; Barrio, Jesús; Esteve, Maria; Merino, Olga; Muñoz, Fernando; Domènech, Eugeni

2015-12-01

Patients with ulcerative colitis (UC) are at increased risk of developing colorectal cancer (CRC), but recent studies suggest a lower risk than previously reported. The aim was to evaluate the incidence of dysplasia, CRC and related risk factors in UC patients from a Spanish nationwide database. All UC patients were identified and retrospectively reviewed. Clinical-epidemiological data and the finding of dysplasia and/or CRC were collected. A total of 831 UC patients were included. Twenty-six cases of CRC in 26 patients and 29 cases of high-grade dysplasia (HGD) in 24 patients were found, accounting for 55 diagnoses of advanced neoplasia (AN = CRC and/or HGD) in 45 patients (33% of them within the first 8 years after UC diagnosis). The cumulative risk of AN was 2, 5.3 and 14.7% at 10, 20 and 30 years, respectively. Concomitant primary sclerosing cholangitis (odds ratio [OR] 10.90; 95% confidence interval [CI] 3.75-31.76, p < 0.001), extensive UC (OR 2.10, 95% CI 1.01-4.38, p = 0.048), UC diagnosis at an older age (OR 2.23, 95% CI 1.03-4.83, p = 0.043) and appendectomy prior to UC diagnosis (OR 2.66, 95% CI 1.06-6.71, p = 0.038) were independent risk factors for AN. Use of thiopurines (OR 0.21, 95% CI 0.06-0.74, p = 0.015) and being in a surveillance colonoscopy programme (OR 0.33; 95% CI 0.16-0.67; p = 0.002) were independent protective factors for AN. The risk of AN among UC patients is lower than previously reported but steadily increases from the time of UC diagnosis. The widespread use of thiopurines may have influenced this reduced incidence of UC-related neoplasias. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Covered Metallic Stents With an Anti-Migration Design vs. Uncovered Stents for the Palliation of Malignant Gastric Outlet Obstruction: A Multicenter, Randomized Trial

PubMed Central

Lee, Hyuk; Min, Byung-Hoon; Lee, Jeong Hoon; Shin, Cheol Min; Kim, Younjoo; Chung, Hyunsoo; Lee, Sang Hyub

2015-01-01

OBJECTIVES: Previous studies reported comparable stent patency between covered self-expandable metallic stents (SEMS) and uncovered SEMS (UCS) for palliation of malignant gastric outlet obstruction (GOO). The aim of this study was to evaluate the efficacy and safety of the newly developed WAVE-covered SEMS (WCS), which has an anti-migration design, compared with UCS in gastric cancer patients with symptomatic GOO. METHODS: A total of 102 inoperable gastric cancer patients with symptomatic GOO were prospectively enrolled from five referral centers and randomized to undergo UCS or WCS placement. Stent patency and recurrence of obstructive symptoms were assessed at 8 weeks and 16 weeks after stent placement. RESULTS: At the 8-week follow-up, both stent patency rates (72.5% vs. 62.7%) and re-intervention rates (19.6% vs. 19.6%) were comparable between the WCS and the UCS groups. Both stent stenosis (2.4% vs. 8.1%) and migration rates (9.5% vs. 5.4%) were comparable between WCS and UCS groups. At the 16-week follow-up, however, the WCS group had a significantly higher stent patency rate than the UCS group (68.6% vs. 41.2%). Re-intervention rates in the WCS and UCS groups were 23.5% and 39.2%, respectively. Compared with the UCS group, the WCS group had a significantly lower stent restenosis rate (7.1% vs. 37.8%) and a comparable migration rate (9.5% vs. 5.4%). Overall stent patency was significantly longer in the WCS group than in the UCS group. No stent-associated significant adverse events occurred in either the WCS or UCS groups. In the multivariate analysis, WCS placement and chemotherapy were identified as independent predictors of 16-week stent patency. CONCLUSIONS: WCS group showed comparable migration rate and significantly more durable long-term stent patency compared with UCS group for the palliation of GOO in patients with inoperable gastric cancer. PMID:26372507

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeff Neaton

Jan. 22, 2010: Host Alice Egan of Berkeley Lab's Materials Sciences Division interviews scientists about their lives and work in language everyone can understand. Her guest Berkeley Lab's MIke Crommie.

Transplanted Umbilical Cord Mesenchymal Stem Cells Modify the In Vivo Microenvironment Enhancing Angiogenesis and Leading to Bone Regeneration

PubMed Central

Todeschi, Maria Rosa; El Backly, Rania; Capelli, Chiara; Daga, Antonio; Patrone, Eugenio; Introna, Martino; Cancedda, Ranieri

2015-01-01

Umbilical cord mesenchymal stem cells (UC-MSCs) show properties similar to bone marrow mesenchymal stem cells (BM-MSCs), although controversial data exist regarding their osteogenic potential. We prepared clinical-grade UC-MSCs from Wharton's Jelly and we investigated if UC-MSCs could be used as substitutes for BM-MSCs in muscoloskeletal regeneration as a more readily available and functional source of MSCs. UC-MSCs were loaded onto scaffolds and implanted subcutaneously (ectopically) and in critical-sized calvarial defects (orthotopically) in mice. For live cell-tracking experiments, UC-MSCs were first transduced with the luciferase gene. Angiogenic properties of UC-MSCs were tested using the mouse metatarsal angiogenesis assay. Cell secretomes were screened for the presence of various cytokines using an array assay. Analysis of implanted scaffolds showed that UC-MSCs, contrary to BM-MSCs, remained detectable in the implants for 3 weeks at most and did not induce bone formation in an ectopic location. Instead, they induced a significant increase of blood vessel ingrowth. In agreement with these observations, UC-MSC-conditioned medium presented a distinct and stronger proinflammatory/chemotactic cytokine profile than BM-MSCs and a significantly enhanced angiogenic activity. When UC-MSCs were orthotopically transplanted in a calvarial defect, they promoted increased bone formation as well as BM-MSCs. However, at variance with BM-MSCs, the new bone was deposited through the activity of stimulated host cells, highlighting the importance of the microenvironment on determining cell commitment and response. Therefore, we propose, as therapy for bone lesions, the use of allogeneic UC-MSCs by not depositing bone matrix directly, but acting through the activation of endogenous repair mechanisms. PMID:25685989

Healthcare Utilisation and Drug Treatment in a Large Cohort of Patients with Inflammatory Bowel Disease

PubMed Central

Wettermark, Björn; Löfberg, Robert; Eriksson, Irene; Sundström, Johan; Lördal, Mikael

2016-01-01

Background and Aims: Crohn’s disease [CD] and ulcerative colitis [UC] are chronic diseases associated with a substantial utilisation of healthcare resources. We aimed to estimate the prevalence of inflammatory bowel disease [IBD], CD, and UC and to describe and compare healthcare utilisation and drug treatment in CD and UC patients. Methods: This was a cross-sectional study of all patients with a recorded IBD diagnosis in Stockholm County, Sweden. Data on outpatient visits, hospitalisations, surgeries, and drug treatment during 2013 were analysed. Results: A total of 13 916 patients with IBD were identified, corresponding to an overall IBD prevalence of 0.65% [CD 0.27%, UC 0.35%, inflammatory bowel disease unclassified 0.04%]; 49% of all IBD patients were treated with IBD-related drugs. Only 3.6% of the patients received high-dose corticosteroids, whereas 32.4% were treated with aminosalicylates [CD 21.2%, UC 41.0%, p < 0.0001]. More CD patients were treated with biologicals compared with UC patients [CD 9.6%, UC 2.9%, p < 0.0001] and surgery was significantly more common among CD patients [CD 3.0%, UC 0.8%, p < 0.0001]. Conclusions: This study indicates that patients with CD are the group with the highest medical needs. Patients with CD utilised significantly more healthcare resources [including outpatient visits, hospitalisations, and surgeries] than UC patients. Twice as many CD patients received immunomodulators compared with UC patients and CD patients were treated with biologicals three times more often. These results highlight that CD remains a challenge and further efforts are needed to improve care in these patients. PMID:26733406

Prevalence of inflammatory bowel disease in two districts of Sri Lanka: a hospital based survey

PubMed Central

2010-01-01

Background Inflammatory bowel disease (IBD) is being increasingly diagnosed in Asia. However there are few epidemiological data from the region. Methods To determine prevalence and clinical characteristics of IBD, a hospital-based survey was performed in the Colombo and Gampaha districts (combined population 4.5 million) in Sri Lanka. Patients with established ulcerative colitis (UC) and Crohn's disease (CD), who were permanent residents of these adjoining districts, were recruited from hospital registries and out-patient clinics. Clinical information was obtained from medical records and patient interviews. Results There were 295 cases of IBD (UC = 240, CD = 55), of which 34 (UC = 30, CD = 4) were newly diagnosed during the study year. The prevalence rate for UC was 5.3/100,000 (95% CI 5.0-5.6/100,000), and CD was 1.2/100,000 (95% CI 1.0-1.4/100,000). The incidence rates were 0.69/100,000 (95% CI 0.44-0.94/100,000) for UC and 0.09/100,000 (95% CI 0.002-0.18/100,000) for CD. Female:male ratios were 1.5 for UC and 1.0 for CD. Mean age at diagnosis was (males and females) 36.6 and 38.1y for UC and 33.4 and 36.2y for CD. Among UC patients, 51.1% had proctitis and at presentation 58.4% had mild disease. 80% of CD patients had only large bowel involvement. Few patients had undergone surgery. Conclusions The prevalence of IBD in this population was low compared to Western populations, but similar to some in Asia. There was a female preponderance for UC. UC was mainly mild, distal or left-sided, while CD mainly involved the large bowel. PMID:20302651

Are HLA-DR or TAP genes genetic markers of severity in ulcerative colitis?

PubMed

Heresbach, D; Alizadeh, M; Reumaux, D; Colombel, J F; Delamaire, M; Danze, P M; Gosselin, M; Genetet, B; Bretagne, J F; Semana, G

1996-12-01

The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, characterized by immunological markers such as atypical ANCA (p-ANCA), or to inclusion of more or less intractable UC. The aim of our study is to evaluate the interest of HLA class II and TAP genetic markers to identify different clinical forms of UC, according to p-ANCA status. Unrelated patients with a history of UC (n = 91) and healthy control subjects with no personal or family history of inflammatory bowel diseases (IBD) (n = 200) were included. HLA-DRB1*03 was less frequent in UC patients than in healthy controls (8% vs 28%, PC < 0.03). No association was found with any TAP genotypes. Moreover, there was no association with the HLA-DR2 specificity, either in the entire group of UC patients (38% vs 28%) or in the p-ANCA-positive subgroup of patients (30%). The most consistent finding in the present study is that some genetic markers may characterize intractability in UC patients. HLA-DR2 was associated with poor prognosis, regardless of p-ANCA status. In HLA-DR2 and non-HLA-DR2 groups, colectomy was done in 55% and 27% of patients, respectively, (PC < 0.05). Furthermore, in non-HLA-DR2 patients, p-ANCA could be of interest to characterize those with more severe prognosis. Our results confirm the interest of genetic studies to define UC genetic susceptibility, taking into account intractability of the disease. They do not support the hypothesis that p-ANCA is a subclinical marker of genetic susceptibility to UC.

Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis.

PubMed

Iwamoto, Taku; Yashima, Kazuo; Morio, Keiko; Ueda, Naoki; Ikebuchi, Yuichiro; Kawaguchi, Koichiro; Harada, Kenichi; Isomoto, Hajime

2018-03-01

The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn's disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC. In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients. In addition, whether the HLA alleles are related to patient and clinical background characteristics was examined. Overall, 62.2%, and 66.7% of the 45 UC patients had HLA-B*52 and HLA-DRB1*15, respectively. These allele frequencies were significantly higher than in previously reported Japanese control persons ( P < 0.0001). The frequencies of extraintestinal manifestations [odds ratio (OR) = 0.12, P = 0.039] and a history of colectomy (OR = 0.18, P = 0.046) were lower in HLA-B*52-positive UC patients than in HLA-B*52 negative UC patients. The white blood cell (WBC) count was significantly higher in HLA-DRB1*15-positive patients (9430 ± 4592/μL) than in HLA-DRB1*15-negative patients (6729 ± 2160/μL). Thus, HLA-B*52 and DRB1*15 appear to be associated with disease features and severity in Japanese UC patients. These results indicate that HLA-B*52 and DRB1*15 are not only associated with overall UC susceptibility, but also with the clinical phenotypes in Japanese patients.

Ultrasonic scalpel causes greater depth of soft tissue necrosis compared to monopolar electrocautery at standard power level settings in a pig model

PubMed Central

2012-01-01

Background Ultrasonic scalpel (UC) and monopolar electrocautery (ME) are common tools for soft tissue dissection. However, morphological data on the related tissue alteration are discordant. We developed an automatic device for standardized sample excision and compared quality and depth of morphological changes caused by UC and ME in a pig model. Methods 100 tissue samples (5 × 3 cm) of the abdominal wall were excised in 16 pigs. Excisions were randomly performed manually or by using the self-constructed automatic device at standard power levels (60 W cutting in ME, level 5 in UC) for abdominal surgery. Quality of tissue alteration and depth of coagulation necrosis were examined histopathologically. Device (UC vs. ME) and mode (manually vs. automatic) effects were studied by two-way analysis of variance at a significance level of 5%. Results At the investigated power level settings UC and ME induced qualitatively similar coagulation necroses. Mean depth of necrosis was 450.4 ± 457.8 μm for manual UC and 553.5 ± 326.9 μm for automatic UC versus 149.0 ± 74.3 μm for manual ME and 257.6 ± 119.4 μm for automatic ME. Coagulation necrosis was significantly deeper (p < 0.01) when UC was used compared to ME. The mode of excision (manual versus automatic) did not influence the depth of necrosis (p = 0.85). There was no significant interaction between dissection tool and mode of excision (p = 0.93). Conclusions Thermal injury caused by UC and ME results in qualitatively similar coagulation necrosis. The depth of necrosis is significantly greater in UC compared to ME at investigated standard power levels. PMID:22361346

Ultrasonic scalpel causes greater depth of soft tissue necrosis compared to monopolar electrocautery at standard power level settings in a pig model.

PubMed

Homayounfar, Kia; Meis, Johanna; Jung, Klaus; Klosterhalfen, Bernd; Sprenger, Thilo; Conradi, Lena-Christin; Langer, Claus; Becker, Heinz

2012-02-23

Ultrasonic scalpel (UC) and monopolar electrocautery (ME) are common tools for soft tissue dissection. However, morphological data on the related tissue alteration are discordant. We developed an automatic device for standardized sample excision and compared quality and depth of morphological changes caused by UC and ME in a pig model. 100 tissue samples (5 × 3 cm) of the abdominal wall were excised in 16 pigs. Excisions were randomly performed manually or by using the self-constructed automatic device at standard power levels (60 W cutting in ME, level 5 in UC) for abdominal surgery. Quality of tissue alteration and depth of coagulation necrosis were examined histopathologically. Device (UC vs. ME) and mode (manually vs. automatic) effects were studied by two-way analysis of variance at a significance level of 5%. At the investigated power level settings UC and ME induced qualitatively similar coagulation necroses. Mean depth of necrosis was 450.4 ± 457.8 μm for manual UC and 553.5 ± 326.9 μm for automatic UC versus 149.0 ± 74.3 μm for manual ME and 257.6 ± 119.4 μm for automatic ME. Coagulation necrosis was significantly deeper (p < 0.01) when UC was used compared to ME. The mode of excision (manual versus automatic) did not influence the depth of necrosis (p = 0.85). There was no significant interaction between dissection tool and mode of excision (p = 0.93). Thermal injury caused by UC and ME results in qualitatively similar coagulation necrosis. The depth of necrosis is significantly greater in UC compared to ME at investigated standard power levels.

Nationwide analysis on the impact of socioeconomic land use factors and incidence of urothelial carcinoma.

PubMed

Brandt, Maximilian P; Gust, Kilian M; Mani, Jens; Vallo, Stefan; Höfner, Thomas; Borgmann, Hendrik; Tsaur, Igor; Thomas, Christian; Haferkamp, Axel; Herrmann, Eva; Bartsch, Georg

2018-02-01

Incidence rates for urothelial carcinoma (UC) have been reported to differ between countries within the European Union (EU). Besides occupational exposure to chemicals, other substances such as tobacco and nitrite in groundwater have been identified as risk factors for UC. We investigated if regional differences in UC incidence rates are associated with agricultural, industrial and residential land use. Newly diagnosed cases of UC between 2003 and 2010 were included. Information within 364 administrative districts of Germany from 2004 for land use factors were obtained and calculated as a proportion of the total area of the respective administrative district and as a smoothed proportion. Furthermore, information on smoking habits was included in our analysis. Kulldorff spatial clustering was used to detect different clusters. A negative binomial model was used to test the spatial association between UC incidence as a ratio of observed versus expected incidence rates, land use and smoking habits. We identified 437,847,834 person years with 171,086 cases of UC. Cluster analysis revealed areas with higher incidence of UC than others (p=0.0002). Multivariate analysis including significant pairwise interactions showed that the environmental factors were independently associated with UC (p<0.001). The RR was 1.066 (95% CI 1.052-1.080), 1.066 (95% CI 1.042-1.089) and 1.067 (95% CI 1.045-1.093) for agricultural, industrial and residential areas, respectively, and 0.996 (95% CI 0.869-0.999) for the proportion of never smokers. This study displays regional differences in incidence of UC in Germany. Additionally, results suggest that socioeconomic factors based on agricultural, industrial and residential land use may be associated with UC incidence rates. Copyright © 2017 Elsevier Ltd. All rights reserved.

IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis.

PubMed

Peng, Ling-Long; Wang, Ying; Zhu, Feng-Ling; Xu, Wang-Dong; Ji, Xue-Lei; Ni, Jing

2017-01-17

Since a genome-wide association study revealed that Interleukin-23 receptor (IL-23R) gene is a candidate gene for Ulcerative Colitis (UC), many studies have investigated the association between the IL-23R polymorphisms and UC. However, the results were controversial. The aim of the study was to determine whether the IL-23R polymorphisms confer susceptibility to UC. A systematic literature search was carried out to identify all potentially relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association. A total of 33 studies in 32 articles, including 10,527 UC cases and 15,142 healthy controls, were finally involved in the meta-analysis. Overall, a significant association was found between all UC cases and the rs11209026A allele (OR = 0.665, 95% CI = 0.604~0.733, P < 0.001). Similarly, meta-analyses of the rs7517847, rs1004819, rs10889677, rs2201841, rs11209032, rs1495965, rs1343151 and rs11465804 polymorphisms also indicated significant association with all UC (all P < 0.05). Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups. However, subgroup analysis failed to unveil any association between the rs1495965 and rs1343151 polymorphisms and UC in Caucasians or Asians. The meta-analysis suggests significant association between IL-23R polymorphisms and UC, especially in Caucasians.

AKT Pathway Affects Bone Regeneration in Nonunion Treated with Umbilical Cord-Derived Mesenchymal Stem Cells.

PubMed

Qu, Zhiguo; Guo, Shengnan; Fang, Guojun; Cui, Zhenghong; Liu, Ying

2015-04-01

We have previously grafted human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) with blood plasma to treat rat tibia nonunion. To further examine the biological characteristics of this process, we applied an established hUC-MSCs-treated rat nonunion model with the addition of an inhibitor of AKT. SD rats (80) were randomly divided into four groups: a fracture group (positive control); a nonunion group (negative control); a hUC-MSCs grafting with blood plasma group; and a hUC-MSCs grafting with blood plasma & AKT blocker group. The animals were sacrificed under deep anesthesia at 4 and 8 weeks post fracture for analysis. The fracture line became less defined at 4 weeks and disappeared at 8 weeks postoperatively in both the hUC-MSCs grafting with blood plasma and grafting with blood plasma & the AKT blocker, which is similar to the fracture group. Histological immunofluorescence studies showed that the numbers of hUC-MSCs in the calluses were significantly higher in the hUC-MSCs grafting with blood plasma than those in group with the AKT blocker. More bone morphogenetic protein 2 and bone sialoprotein expression and less osteoprotegerin and bone gla protein expression were observed in the AKT blocker group compared to the hUC-MSCs grafting with blood plasma. AKT gene expression in the AKT blocker group was decreased 50% compared to the hUC-MSCs with plasma group and decreased 70% compared to the fracture group, while the elastic modulus was decreased. In summary, our work demonstrates that AKT may play a role in modulating osteogenesis induced by hUC-MSCs.

Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease?

PubMed

Büning, Carsten; Geissler, Nora; Prager, Matthias; Sturm, Andreas; Baumgart, Daniel C; Büttner, Janine; Bühner, Sabine; Haas, Verena; Lochs, Herbert

2012-10-01

A disturbed epithelial barrier could play a pivotal role in ulcerative colitis (UC). We performed a family-based study analyzing in vivo gastrointestinal permeability in patients with UC, their healthy relatives, spouses, and controls. In total, 89 patients with UC in remission, 35 first-degree relatives (UC-R), 24 nonrelated spouses (UC-NR), and 99 healthy controls (HC) were studied. Permeability was assessed by a sugar-drink test using sucrose (gastroduodenal permeability), lactulose/mannitol (intestinal permeability), and sucralose (colonic permeability). Data were correlated with clinical characteristics including medical treatment. Increased intestinal permeability was detected significantly more often in UC patients in remission (25/89, 28.1%) compared with HC (6/99, 6.1%; P < 0.001). Similar results were obtained in UC-R (7/35, 20.0%; P = 0.01 compared with HC) regardless of sharing the same household with the patients or not. No difference was found between UC-NR (3/24, 12.5%) and HC. Notably, in UC patients increased intestinal permeability was found in 12/28 patients (42.9%) with pancolitis, 7/30 (23.3%) patients with left-sided colitis, and in 2/19 (10.5%) patients with proctitis (P = 0.04). Gastroduodenal and colonic permeability were similar in all groups. Among patients on azathioprine, increased intestinal permeability was only seen in 1/18 (5.6%) patients. In contrast, in 24/70 (34.3%) patients without azathioprine, an increased intestinal permeability was found (P = 0.005). An increased intestinal but not colonic permeability was found in UC patients in clinical remission that could mark a new risk factor for extensive disease location. Similar findings in healthy relatives but not spouses suggest that this barrier defect is genetically determined. Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.

IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis

PubMed Central

Peng, Ling-Long; Wang, Ying; Zhu, Feng-Ling; Xu, Wang-Dong; Ji, Xue-Lei; Ni, Jing

2017-01-01

Objectives Since a genome-wide association study revealed that Interleukin-23 receptor (IL-23R) gene is a candidate gene for Ulcerative Colitis (UC), many studies have investigated the association between the IL-23R polymorphisms and UC. However, the results were controversial. The aim of the study was to determine whether the IL-23R polymorphisms confer susceptibility to UC. Methods A systematic literature search was carried out to identify all potentially relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association. Results A total of 33 studies in 32 articles, including 10,527 UC cases and 15,142 healthy controls, were finally involved in the meta-analysis. Overall, a significant association was found between all UC cases and the rs11209026A allele (OR = 0.665, 95% CI = 0.604~0.733, P < 0.001). Similarly, meta-analyses of the rs7517847, rs1004819, rs10889677, rs2201841, rs11209032, rs1495965, rs1343151 and rs11465804 polymorphisms also indicated significant association with all UC (all P < 0.05). Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups. However, subgroup analysis failed to unveil any association between the rs1495965 and rs1343151 polymorphisms and UC in Caucasians or Asians. Conclusions The meta-analysis suggests significant association between IL-23R polymorphisms and UC, especially in Caucasians. PMID:27902482

Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis.

PubMed

Deng, Peng; Wu, Junchao

2016-07-01

This study aimed to investigate the relationship between appendiceal orifice inflammation (AOI) and appendectomy and ulcerative colitis (UC) by a meta-analysis. Databases were thoroughly searched for studies on AOI and UC up to January 2016. Three comparisons were performed: a) whether the previous appendectomy was a risk factor of UC; b) influence of appendectomy on UC courses; c) influence of AOI on UC severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were the effects sizes. The merging of results and publication bias assessment were performed by using RevMan 5.3. Sensitivity analysis was conducted using Stata 12.0. Nineteen studies were selected in the present study. Results of comparison I showed that appendectomy was a protective factor of UC (OR = 0.44; 95% CI [0.30, 0.64]). Comparison II indicated appendectomy had no significant influence in the courses of UC (proctitis: OR = 1.03, 95% CI [0.74, 1.42]; left-sided colitis: OR = 1.01, 95% CI [0.73, 1.39]; pancolitis: OR = 0.92, 95% CI [0.59, 1.43]; colectomy: OR = 1.38, 95% CI [0.62, 3.04]). Comparison III indicated UC combined with AOI did not affect the courses of UC (proctitis: OR = 1.15, 95% CI [0.67, 1.98]; left-sided colitis: OR = 1.14, 95% CI [0.24, 5.42]; colectomy: OR = 0.36, 95% CI [0.10, 1.23]). Sensitivity analysis confirmed the robust of the results in the present study. In conclusion, this meta-analysis indicated appendectomy can reduce the risk of UC. But appendectomy or AOI had no influence on the severity of the disease and the effect of surgical treatment.

Associations between NRAMP1 Polymorphisms and Susceptibility to Ulcerative Colitis/Crohn's Disease: A Meta-Analysis.

PubMed

Sun, Manyi; Zhang, Li; Shi, Songli

2016-01-01

Multiple environmental and genetic factors contribute to the risks of ulcerative colitis (UC) and Crohn's disease (CD). Several allelic variants have been identified in natural resistance associated macrophage protein 1 (NRAMP1) gene; however, their association with UC/CD remains conflicting. The purpose of this study was to evaluate whether NRAMP1 polymorphisms are associated with the susceptibility to UC/CD. A meta-analysis on the association between the NRAMP1 polymorphisms and susceptibility to UC/CD was performed. Relevant studies were retrieved from the databases. After eligible data were extracted, Mantel-Haenszel statistics and random/fixed effects model were applied to calculate the pooled odds radio (OR) and 95% confidence interval (95% CI). Seven articles containing 536 UC cases, 997 CD cases, and 1361 controls were collected. No significant association between allele 2 frequency of NRAMP1 and susceptibility to UC/CD was detected in overall population (all p > 0.05). However, increased UC/CD risk for allele 3 was observed in Caucasian population (OR = 1.27, 95% CI = 1.08~1.50, p = 0.04), whereas decreased UC/CD risk was detected in non-Caucasian population (OR = 0.72, 95% CI = 0.60~0.87, p < 0.001), under "allele 3 vs. other alleles" model. Moreover, a significant increase in CD risk for T carrier frequency of -237 C/T (OR = 0.44, 95% CI, 0.26~0.75, p = 0.003) was detected, but not 274 C/T and 1729+55del4 (TGTG) +/del. The polymorphism of -237 C/T is related to the risk of CD; and the association of allele 3 with UC/CD risk differs in Caucasian and non-Caucasian population, which might be the potential biomarkers for clinical diagnosis of UC/CD.

Efficacy of oral vs. topical, or combined oral and topical 5-aminosalicylates, in Ulcerative Colitis: systematic review and meta-analysis.

PubMed

Ford, Alexander C; Khan, Khurram J; Achkar, Jean-Paul; Moayyedi, Paul

2012-02-01

Efficacy of 5-aminosalicylic acids (5-ASAs) in ulcerative colitis (UC) has been studied previously in meta-analyses. However, no recent meta-analysis has studied the relative efficacies of differing routes of administration. MEDLINE, EMBASE, and the Cochrane central register of controlled trials were searched (through May 2011). Eligible trials recruited adults with mildly to moderately active UC, or quiescent UC, and compared oral 5-ASAs with either topical 5-ASAs or a combination of oral and topical 5-ASAs. Dichotomous data were pooled to obtain relative risk (RR) of failure to achieve remission in active UC, and RR of relapse of disease activity in quiescent UC, with a 95% confidence interval (CI). The number needed to treat (NNT) was calculated from the reciprocal of the risk difference. The search identified 3,061 citations, and 12 randomized controlled trials (RCTs) were eligible. Four compared topical with oral 5-ASAs in active UC remission, with an RR of no remission with topical 5-ASAs of 0.82 (95% CI=0.52-1.28). Four trials compared combined with oral 5-ASAs in active UC (RR of no remission=0.65; 95% CI=0.47-0.91; NNT=5). Three RCTs compared intermittent topical with oral 5-ASAs in preventing relapse of quiescent UC (RR=0.64; 95% CI=0.43-0.95; NNT=4), and two compared combined with oral 5-ASAs (RR of relapse=0.48; 95% CI=0.17-1.38). Combined 5-ASA therapy appeared superior to oral 5-ASAs for induction of remission of mildly to moderately active UC. Intermittent topical 5-ASAs appeared superior to oral 5-ASAs for preventing relapse of quiescent UC.

Ulcerative colitis in smokers, non-smokers and ex-smokers

PubMed Central

Bastida, Guillermo; Beltrán, Belén

2011-01-01

Smoking is a major environmental factor that interferes in the establishment and clinical course of ulcerative colitis (UC). Firstly, the risk of smoking status impact in the development of UC is reviewed, showing that current smoking has a protective association with UC. Similarly, being a former smoker is associated with an increased risk of UC. The concept that smoking could have a role in determining the inflammatory bowel disease phenotype is also discussed. Gender may also be considered, as current smoking delays disease onset in men but not in women. No clear conclusions can be driven from the studies trying to clarify whether childhood passive smoking or prenatal smoke exposure have an influence on the development of UC, mainly due to methodology flaws. The influence of smoking on disease course is the second aspect analysed. Some studies show a disease course more benign in smokers that in non-smokers, with lower hospitalizations rates, less flare-ups, lower use of oral steroids and even less risk of proximal extension. This is not verified by some other studies. Similarly, the rate of colectomy does not seem to be determined by the smoking status of the patient. The third issue reviewed is the use of nicotine as a therapeutic agent. The place of nicotine in the treatment of UC is unclear, although it could be useful in selected cases, particularly in recent ex-smokers with moderate but refractory attacks of UC. Finally, the effect of smoking cessation in UC patients is summarised. Given that smoking represents a major worldwide cause of death, for inpatients with UC the risks of smoking far outweigh any possible benefit. Thus, physicians should advise, encourage and assist UC patients who smoke to quit. PMID:21734782

Investigation of Crohn’s Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

PubMed Central

ANDERSON, CARL A.; MASSEY, DUNECAN C. O.; BARRETT, JEFFREY C.; PRESCOTT, NATALIE J.; TREMELLING, MARK; FISHER, SHEILA A.; GWILLIAM, RHIAN; JACOB, JEMIMA; NIMMO, ELAINE R.; DRUMMOND, HAZEL; LEES, CHARLIE W.; ONNIE, CLIVE M.; HANSON, CATHERINE; BLASZCZYK, KATARZYNA; RAVINDRARAJAH, RADHI; HUNT, SARAH; VARMA, DHIRAJ; HAMMOND, NAOMI; LEWIS, GREGORY; ATTLESEY, HEATHER; WATKINS, NICK; OUWEHAND, WILLEM; STRACHAN, DAVID; MCARDLE, WENDY; LEWIS, CATHRYN M.; LOBO, ALAN; SANDERSON, JEREMY; JEWELL, DEREK P.; DELOUKAS, PANOS; MANSFIELD, JOHN C.; MATHEW, CHRISTOPHER G.; SATSANGI, JACK; PARKES, MILES

2009-01-01

Background & Aims Identifying shared and disease-specific susceptibility loci for Crohn’s disease (CD) and ulcerative colitis (UC) would help define the biologic relationship between the inflammatory bowel diseases. More than 30 CD susceptibility loci have been identified. These represent important candidate susceptibility loci for UC. Loci discovered by the index genome scans in CD have previously been tested for association with UC, but those identified in the recent meta-analysis await such investigation. Furthermore, the recently identified UC locus at ECM1 requires formal testing for association with CD. Methods We analyzed 45 single nucleotide polymorphisms, tagging 29 of the loci recently associated with CD in 2527 UC cases and 4070 population controls. We also genotyped the UC-associated ECM1 variant rs11205387 in 1560 CD patients and 3028 controls. Results Nine regions showed association with UC at a threshold corrected for the 29 loci tested (P < .0017). The strongest association (P = 4.13 × 10-8; odds ratio = 1.27) was identified with a 170-kilobase region on chromosome 1q32 that contains 3 genes. We also found association with JAK2 and replicated a recently reported association with STAT3, further implicating the role of this signaling pathway in inflammatory bowel disease. Additional novel UC susceptibility genes were LYRM4 and CDKAL1. Twenty of the loci were not associated with UC, and several appear to be specific to CD. ECM1 variation was not associated with CD. Conclusions Collectively, these data help define the genetic relationship between CD and UC and characterize common, as well as disease-specific mechanisms of pathogenesis. PMID:19068216

Human umbilical cord mesenchymal stromal cells suppress MHC class II expression on rat vascular endothelium and prolong survival time of cardiac allograft

PubMed Central

Qiu, Ying; Yun, Mark M; Han, Xia; Zhao, Ruidong; Zhou, Erxia; Yun, Sheng

2014-01-01

Background: Human umbilical cord mesenchymal stromal cells (UC-MSCs) have low immunogenicity and immune regulation. To investigate immunomodulatory effects of human UC-MSCs on MHC class II expression and allograft, we transplanted heart of transgenic rats with MHC class II expression on vascular endothelium. Methods: UC-MSCs were obtained from human umbilical cords and confirmed with flow cytometry analysis. Transgenic rat line was established using the construct of human MHC class II transactivator gene (CIITA) under mouse ICAM-2 promoter control. The induced MHC class II expression on transgenic rat vascular endothelial cells (VECs) was assessed with immunohistological staining. And the survival time of cardiac allograft was compared between the recipients with and without UC-MSC transfusion. Results: Flow cytometry confirmed that the human UC-MSCs were positive for CD29, CD44, CD73, CD90, CD105, CD271, and negative for CD34 and HLA-DR. Repeated infusion of human UC-MSCs reduced MHC class II expression on vascular endothelia of transplanted hearts, and increased survival time of allograft. The UC-MSCs increased regulatory cytokines IL10, transforming growth factor (TGF)-β1 and suppressed proinflammatory cytokines IL2 and IFN-γ in vivo. The UC-MSC culture supernatant had similar effects on cytokine expression, and decreased lymphocyte proliferation in vitro. Conclusions: Repeated transfusion of the human UC-MSCs reduced MHC class II expression on vascular endothelia and prolonged the survival time of rat cardiac allograft. PMID:25126177

Profound loss of neprilysin accompanied by decreased levels of neuropeptides and increased CRP in ulcerative colitis.

PubMed

Sargın, Zeynep Gök; Erin, Nuray; Tazegul, Gokhan; Elpek, Gülsüm Özlem; Yıldırım, Bülent

2017-01-01

Neprilysin (NEP, CD10) acts to limit excessive inflammation partly by hydrolyzing neuropeptides. Although deletion of NEP exacerbates intestinal inflammation in animal models, its role in ulcerative colitis (UC) is not well explored. Herein, we aimed to demonstrate changes in NEP and associated neuropeptides at the same time in colonic tissue. 72 patients with UC and 27 control patients were included. Patients' demographic data and laboratory findings, five biopsy samples from active colitis sites and five samples from uninvolved mucosa were collected. Substance P (SP), calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP) were extracted from freshly frozen tissues and measured using ELISA. Levels of NEP expression were determined using immunohistochemistry and immunoreactivity scores were calculated. GEBOES grading system was also used. We demonstrated a profound loss (69.4%) of NEP expression in UC, whereas all healthy controls had NEP expression. Patients with UC had lower neuronal SP; however non-neuronal SP remained similar. UC patients had also lower neuronal and non-neuronal VIP levels. CGRP were low in general and no significant changes were observed. Additionally, CRP positive patients with UC had higher rates of NEP loss (80% vs 51.9%) and lower SP levels when compared with CRP negative patients with UC. Concurrent decreases in SP and VIP with profound loss of NEP expression observed in UC is likely to be one of the factors in pathogenesis. Further studies are required to define the role of neuropeptides and NEP in UC.

Profound loss of neprilysin accompanied by decreased levels of neuropeptides and increased CRP in ulcerative colitis

PubMed Central

Sargın, Zeynep Gök; Tazegul, Gokhan; Elpek, Gülsüm Özlem; Yıldırım, Bülent

2017-01-01

Neprilysin (NEP, CD10) acts to limit excessive inflammation partly by hydrolyzing neuropeptides. Although deletion of NEP exacerbates intestinal inflammation in animal models, its role in ulcerative colitis (UC) is not well explored. Herein, we aimed to demonstrate changes in NEP and associated neuropeptides at the same time in colonic tissue. 72 patients with UC and 27 control patients were included. Patients’ demographic data and laboratory findings, five biopsy samples from active colitis sites and five samples from uninvolved mucosa were collected. Substance P (SP), calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP) were extracted from freshly frozen tissues and measured using ELISA. Levels of NEP expression were determined using immunohistochemistry and immunoreactivity scores were calculated. GEBOES grading system was also used. We demonstrated a profound loss (69.4%) of NEP expression in UC, whereas all healthy controls had NEP expression. Patients with UC had lower neuronal SP; however non-neuronal SP remained similar. UC patients had also lower neuronal and non-neuronal VIP levels. CGRP were low in general and no significant changes were observed. Additionally, CRP positive patients with UC had higher rates of NEP loss (80% vs 51.9%) and lower SP levels when compared with CRP negative patients with UC. Concurrent decreases in SP and VIP with profound loss of NEP expression observed in UC is likely to be one of the factors in pathogenesis. Further studies are required to define the role of neuropeptides and NEP in UC. PMID:29232715

Immunosuppressive function of mesenchymal stem cells from human umbilical cord matrix in immune thrombocytopenia patients.

PubMed

Ma, Li; Zhou, Zeping; Zhang, Donglei; Yang, Shaoguang; Wang, Jinhong; Xue, Feng; Yang, Yanhui; Yang, Renchi

2012-05-01

Human umbilical cord matrix/Wharton's jelly (hUC)-derived mesenchymal stem cells (MSC) have been shown to have marked therapeutic effects in a number of inflammatory diseases and autoimmune diseases in humans based on their potential for immunosuppression and their low immunogenicity. Currently, no data are available on the effectiveness of UC-MSC transplantation in immune thrombocytopenia (ITP) patients. It was the objective of this study to assess the effect of allogeneic UC-MSCs on ITP patients in vitro and in vivo. Peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BM-MNCs) from ITP patients and healthy controls were co-cultured with UC-MSCs for three days and seven days, respectively. Flow cytometry and ELISA were applied to assess the various parameters. In PBMCs from ITP patients, the proliferation of autoreactive T, B lymphocytes and destruction of autologous platelets were dramatically suppressed by UC-MSCs. UC-MSCs not only suppressed co-stimulatory molecules CD80, CD40L and FasL expression but also in shifting Th1/Th2/Treg cytokines profile in ITP patients. UC-MSCs obviously reversed the dysfunctions of megakaryocytes by promoting platelet production and decreasing the number of living megakaryocytes as well as early apoptosis. In addition, the level of thrombopoietin was increased significantly. Our clinical study showed that UC-MSCs play a role in alleviating refractory ITP by increasing platelet numbers. These findings suggested that UC-MSCs transplantation might be a potential therapy for ITP.

Bridging the PSI Knowledge Gap: A Multi-Scale Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wirth, Brian D.

2015-01-08

Plasma-surface interactions (PSI) pose an immense scientific hurdle in magnetic confinement fusion and our present understanding of PSI in confinement environments is highly inadequate; indeed, a recent Fusion Energy Sciences Advisory Committee report found that 4 out of the 5 top five fusion knowledge gaps were related to PSI. The time is appropriate to develop a concentrated and synergistic science effort that would expand, exploit and integrate the wealth of laboratory ion-beam and plasma research, as well as exciting new computational tools, towards the goal of bridging the PSI knowledge gap. This effort would broadly advance plasma and material sciences,more » while providing critical knowledge towards progress in fusion PSI. This project involves the development of a Science Center focused on a new approach to PSI science; an approach that both exploits access to state-of-the-art PSI experiments and modeling, as well as confinement devices. The organizing principle is to develop synergistic experimental and modeling tools that treat the truly coupled multi-scale aspect of the PSI issues in confinement devices. This is motivated by the simple observation that while typical lab experiments and models allow independent manipulation of controlling variables, the confinement PSI environment is essentially self-determined with few outside controls. This means that processes that may be treated independently in laboratory experiments, because they involve vastly different physical and time scales, will now affect one another in the confinement environment. Also, lab experiments cannot simultaneously match all exposure conditions found in confinement devices typically forcing a linear extrapolation of lab results. At the same time programmatic limitations prevent confinement experiments alone from answering many key PSI questions. The resolution to this problem is to usefully exploit access to PSI science in lab devices, while retooling our thinking from a linear and de-coupled extrapolation to a multi-scale, coupled approach. The PSI Plasma Center consisted of three equal co-centers; one located at the MIT Plasma Science and Fusion Center, one at UC San Diego Center for Energy Research and one at the UC Berkeley Department of Nuclear Engineering, which moved to the University of Tennessee, Knoxville (UTK) with Professor Brian Wirth in July 2010. The Center had three co-directors: Prof. Dennis Whyte led the MIT co-center, the UCSD co-center was led by Dr. Russell Doerner, and Prof. Brian Wirth led the UCB/UTK center. The directors have extensive experience in PSI and material research, and have been internationally recognized in the magnetic fusion, materials and plasma research fields. The co-centers feature keystone PSI experimental and modeling facilities dedicated to PSI science: the DIONISOS/CLASS facility at MIT, the PISCES facility at UCSD, and the state-of-the-art numerical modeling capabilities at UCB/UTK. A collaborative partner in the center is Sandia National Laboratory at Livermore (SNL/CA), which has extensive capabilities with low energy ion beams and surface diagnostics, as well as supporting plasma facilities, including the Tritium Plasma Experiment, all of which significantly augment the Center. Interpretive, continuum material models are available through SNL/CA, UCSD and MIT. The participating institutions of MIT, UCSD, UCB/UTK, SNL/CA and LLNL brought a formidable array of experimental tools and personnel abilities into the PSI Plasma Center. Our work has focused on modeling activities associated with plasma surface interactions that are involved in effects of He and H plasma bombardment on tungsten surfaces. This involved performing computational material modeling of the surface evolution during plasma bombardment using molecular dynamics modeling. The principal outcomes of the research efforts within the combined experimental – modeling PSI center are to provide a knowledgebase of the mechanisms of surface degradation, and the influence of the surface on plasma conditions.« less

Comparing Electric Shock and a Fearful Screaming Face as Unconditioned Stimuli for Fear Learning

PubMed Central

Glenn, Catherine R.; Lieberman, Lynne; Hajcak, Greg

2012-01-01

The potency of an unconditioned stimulus (UCS) can impact the degree of fear learning. One of the most common and effective UCSs is an electric shock, which is inappropriate for certain populations (e.g., children). To address this need, a novel fear learning paradigm was recently developed that uses a fearful female face and scream as the UCS. The present study directly compared the efficacy of the screaming female UCS and a traditional shock UCS in two fear learning paradigms. Thirty-six young adults completed two fear learning tasks and a measure of trait anxiety; fear learning was indexed with fear-potentiated startle (FPS) and self-reported fear ratings. Results indicated comparable FPS across the two tasks. However, larger overall startle responses were exhibited in the shock task, and participants rated the shock UCS and overall task as more aversive than the screaming female. In addition, trait anxiety was only related to FPS in the fear learning task that employed a shock as the UCS. Taken together, results indicate that, although both UCS paradigms can be used for fear conditioning (i.e., to produce differences between CS+ and CS−), the shock UCS paradigm is more aversive and potentially more sensitive to individual differences in anxiety. PMID:23007035

Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case.

PubMed

Sada, Haruki; Shimomura, Manabu; Hinoi, Takao; Egi, Hiroyuki; Kawaguchi, Koji; Yano, Takuya; Niitsu, Hiroaki; Saitou, Yasufumi; Sawada, Hiroyuki; Miguchi, Masashi; Adachi, Tomohiro; Ohdan, Hideki

2015-03-26

The standard operation for colitic cancer in ulcerative colitis (UC) is restorative proctocolectomy; however, sporadic colorectal cancer (CRC) can coincidentally arise in patients with UC and the optimal procedure remains controversial. Therefore, it is crucial to preoperatively determine whether the CRC in UC is a sporadic or colitic cancer. We report a case of avoiding proctocolectomy for sporadic CRC in a patient with UC based on preoperative diagnosis involving p53 immunostaining. A 73-year-old man with CRC in UC had undergone sigmoid colectomy with lymphadenectomy because of the submucosal deep invasion pathologically after endoscopic mucosal resection. The cancer was diagnosed sporadic cancer preoperatively not only based on the endoscopic, clinical, and histological patterns but also that the colon epithelium was unlikely to develop dysplasia as the circumference and unaffected UC mucosa did not detect p53 protein overexpression. Recent reports have shown that the immunohistochemical detection of p53 protein overexpression can be useful for a differential diagnosis and as a predictor of dysplasia and colitic cancer. The analysis of p53 mutation status based on immunostaining of p53 protein expression in the unaffected UC mucosa can be useful for the decision regarding a surgical procedure for CRC in patients with UC.

[Expression and clinical significance of 5hmC in bladder urothelial carcinoma].

PubMed

Li, Jie; Xu, Yuqiao; Zhang, Zhiwen; Zhang, Ming; Zhang, Zhekai; Zhang, Feng; Li, Qing

2016-02-01

To investigate the expression of 5-hydroxymethylcytosine (5hmC) in bladder urothelial carcinoma (UC) and its clinical significance. The expression of 5hmC in 21 cases of UC tissues and pericarcinous urinary tract epithelium was detected by immunohistochemical staining. Then the expression of 5hmC in the surgical resection of UC tissues in 92 cases was also surveyed. Non parametric U Mann-Whitney test was used to analyze the correlation between 5hmC expression and clinical data. Single factor survival analysis was performed by Kaplan-Meier test. The expression of 5hmC in normal urinary tract epithelium and UC tissues was significantly different, but there was no significant difference in the expression of 5hmC between low and high grades of UC tissues as well as between different TNM grades. Kaplan-Meier single factor survival analysis showed that there was no significant correlation between the 5hmC expression level and the survival rate or the recurrence-free survival of UC patients. The expression level of 5hmC in UC tissues is significantly lower than that in pericarcinous urinary tract epithelium. There is no correlation between the 5hmC expression and the progression, prognosis and recurrence of UC.

Professional charges not reimbursed to dentists in the U.S.: evidence from Medical Expenditure Panel Survey, 1996.

PubMed

Chattopadhyay, A; Slade, G D; Caplan, D J

2009-12-01

This cross-sectional study examined professional charges not paid to dentists. This analysis used logistic regression in SUDAAN examining the 1996 MEPS data from 12,931 adults. Among people incurring dental care charges, 13.6% had more than $50 of unpaid charge (UC). The percapita UC was $53.30. Total UC was higher for highest income group [45.4% of total] compared to lowest income group [26.0%]. The percapita UC of $76.70 for low income group was significantly greater than for high income group ($47.80, P < 0.01). More Medicaid recipients (52% vs. non-recipients: 12%) incurred at least $50 in UC (P < 0.01). Adjusted odds of incurring UC were greater for those employed (OR = 1.3, 95% CI: 1.0-1.7), and for those with private insurance (OR: 1.5, CI: 1.3-1.9). Number of dental procedure types modified the association between Medicaid recipient and UC (OR = 13.6 for Medicaid recipients undergoing multiple procedure types; OR: 2.3 for Medicaid non-recipients with multiple procedure types; OR: 1.9 for Medicaid recipients receiving single dental procedure. Having private insurance, being unemployed and being Medicaid insured undergoing multiple procedure were strongest predictors of UC.

Golimumab in unresponsive ulcerative colitis

PubMed Central

Lippert, Elisabeth; Müller, Martina; Ott, Claudia

2014-01-01

Ulcerative colitis (UC) is a chronic inflammation mainly affecting the colon mucosa. It predominantly occurs in younger patients. Until recently, the main goals in the treatment of UC were to temper the symptoms, such as diarrhea, pain, and weight loss, by using mesalazine and steroids. With newer medications, such as immunomodulators (thiopurines) and the biologics providing blockade of tumor necrosis factor (TNF), the goals of the therapy in UC have changed to long-term remission and mucosal healing. The first available anti-TNF therapy in UC included infusion therapy with infliximab every few weeks. In 2012, subcutaneously administered adalimumab gained approval for the treatment of UC in Germany. In patients with a mild disease, therapy with mesalazine, orally or topically, can be sufficient. In patients with moderate to severe disease, therapy with azathioprine or anti-TNF is often required to reach disease control; however, this is only efficient in about two-thirds of patients. Some patients either show no response or a lost response while on treatment. So, further medical options are warranted in the treatment of UC. With golimumab, a new approach in the treatment of mild to moderate UC recently became available in Germany and is a promising new option in the therapy regimen for patients with UC. PMID:24904202

Antilaminaribioside and antichitobioside antibodies in inflammatory bowel disease.

PubMed

Rejchrt, S; Drahosová, M; Kopácová, M; Cyrany, J; Douda, T; Pintér, M; Bures, J

2008-01-01

Testing antilaminaribioside (ALCA) and antichitobioside (ACCA) antibodies in 89 Crohn's disease (CD), 31 ulcerative colitis (UC) and 50 controls, mean values were 38.6 and 53.0 ELISA units for CD, 34.0 and 32.6 for UC, 34.5 and 36.4 for controls, respectively. There was no significant difference of ALCA values between CD and UC (p = 0.401), CD and control subjects (p = 0.698) or UC and controls (p = 0.898). ACCA were significantly higher in CD compared with UC (p = 0.011) but not with the controls (p = 0.095). No significant difference of ACCA values between UC and controls (p = 0.107) was found. ALCA and ACCA values significantly correlated in CD (r = 0.548, p < 10(-4)) and UC (r = 0.885, p < 10(-4)) but not in controls (r = 0.153, p = 0.287). The positive predictive value for CD was only 20 (ALCA) and 8 % (ACCA), the negative ones (to exclude CD) 25 (ALCA) and 86 % (ACCA). Small and/or large bowel involvement or disease type (i.e. stenosing, perforating or inflammatory) of CD did not differ in the two values. The idea that ALCA and ACCA may be useful either to differentiate between CD, UC and healthy subjects or to stratify CD was not confirmed.

The system design of TRIO cinema Mission

NASA Astrophysics Data System (ADS)

Jin, Ho; Seon, Jongho; Kim, Khan-Hyuk; Lee, Dong-Hun; Kim, Kap-Sung; Lin, Robert; Parks, George; Tindall, Craig; Horbury, T. S.; Larson, Davin; Sample, John

TRIO (Triplet Ionospheric Observatory) CINEMA ( Cubesat for Ion, Neutral, Electron, MAg-netic fields) is a space science mission with three identical cubesats. The main scientific objec-tives are a multi-observation of ionospheric ENA (Energetic Neutral Atom) imaging, ionospheric signature of suprathermal electrons and ions and complementary measurements of magnetic fields for particle data. For this, Main payloads consist of a suprathermal electron, ion, neutral (STEIN) instrument and a 3-axis magnetometer of magnetoresistive sensors. The CINEMA is a 3-unit CubeSat, which translates to a 10 cm x 10 cm x 30 cm in volume and no more than four kilograms in mass. An attitude control system (ACS) uses torque coils, a sun sensor and the magnetometers and spin CINEMA spcaecraft 4 rpm with the spin axis perpendicular to the ecliptic plane. CINEMA will be placed into a high inclination low earth orbit that crosses the auroral zone and cusp. Three institutes are collaborating to develop CINEMA cubesats: i) two cubesats by Kyung Hee University (KHU) under their World Class University (WCU) program, ii) one cubesat by UC Berkeley under the NSF support, and iii) three magnetometers are provide by Imperial College, respectively. In this paper, we describe the system design and their performance of TR IO cinema mission. TRIO cinema's development of miniature in-strument and spacecraft spinning operation will play an important role for future nanosatellite space missions

TRIO (Triplet Ionospheric Observatory) Mission

NASA Astrophysics Data System (ADS)

Lee, D.; Seon, J.; Jin, H.; Kim, K.; Lee, J.; Jang, M.; Pak, S.; Kim, K.; Lin, R. P.; Parks, G. K.; Halekas, J. S.; Larson, D. E.; Eastwood, J. P.; Roelof, E. C.; Horbury, T. S.

2009-12-01

Triplets of identical cubesats will be built to carry out the following scientific objectives: i) multi-observations of ionospheric ENA (Energetic Neutral Atom) imaging, ii) ionospheric signature of suprathermal electrons and ions associated with auroral acceleration as well as electron microbursts, and iii) complementary measurements of magnetic fields for particle data. Each satellite, a cubesat for ion, neutral, electron, and magnetic fields (CINEMA), is equipped with a suprathermal electron, ion, neutral (STEIN) instrument and a 3-axis magnetometer of magnetoresistive sensors. TRIO is developed by three institutes: i) two CINEMA by Kyung Hee University (KHU) under the WCU program, ii) one CINEMA by UC Berkeley under the NSF support, and iii) three magnetometers by Imperial College, respectively. Multi-spacecraft observations in the STEIN instruments will provide i) stereo ENA imaging with a wide angle in local times, which are sensitive to the evolution of ring current phase space distributions, ii) suprathermal electron measurements with narrow spacings, which reveal the differential signature of accelerated electrons driven by Alfven waves and/or double layer formation in the ionosphere between the acceleration region and the aurora, and iii) suprathermal ion precipitation when the storm-time ring current appears. In addition, multi-spacecraft magnetic field measurements in low earth orbits will allow the tracking of the phase fronts of ULF waves, FTEs, and quasi-periodic reconnection events between ground-based magnetometer data and upstream satellite data.

Exploring the performance of large-N radio astronomical arrays

NASA Astrophysics Data System (ADS)

Lonsdale, Colin J.; Doeleman, Sheperd S.; Cappallo, Roger J.; Hewitt, Jacqueline N.; Whitney, Alan R.

2000-07-01

New radio telescope arrays are currently being contemplated which may be built using hundreds, or even thousands, of relatively small antennas. These include the One Hectare Telescope of the SETI Institute and UC Berkeley, the LOFAR telescope planned for the New Mexico desert surrounding the VLA, and possibly the ambitious international Square Kilometer Array (SKA) project. Recent and continuing advances in signal transmission and processing technology make it realistic to consider full cross-correlation of signals from such a large number of antennas, permitting the synthesis of an aperture with much greater fidelity than in the past. In principle, many advantages in instrumental performance are gained by this 'large-N' approach to the design, most of which require the development of new algorithms. Because new instruments of this type are expected to outstrip the performance of current instruments by wide margins, much of their scientific productivity is likely to come from the study of objects which are currently unknown. For this reason, instrumental flexibility is of special importance in design studies. A research effort has begun at Haystack Observatory to explore large-N performance benefits, and to determine what array design properties and data reduction algorithms are required to achieve them. The approach to these problems, involving a sophisticated data simulator, algorithm development, and exploration of array configuration parameter space, will be described, and progress to date will be summarized.

Validation of hydrogen gas stratification and mixing models

DOE PAGES

Wu, Hsingtzu; Zhao, Haihua

2015-05-26

Two validation benchmarks confirm that the BMIX++ code is capable of simulating unintended hydrogen release scenarios efficiently. The BMIX++ (UC Berkeley mechanistic MIXing code in C++) code has been developed to accurately and efficiently predict the fluid mixture distribution and heat transfer in large stratified enclosures for accident analyses and design optimizations. The BMIX++ code uses a scaling based one-dimensional method to achieve large reduction in computational effort compared to a 3-D computational fluid dynamics (CFD) simulation. Two BMIX++ benchmark models have been developed. One is for a single buoyant jet in an open space and another is for amore » large sealed enclosure with both a jet source and a vent near the floor. Both of them have been validated by comparisons with experimental data. Excellent agreements are observed. The entrainment coefficients of 0.09 and 0.08 are found to fit the experimental data for hydrogen leaks with the Froude number of 99 and 268 best, respectively. In addition, the BIX++ simulation results of the average helium concentration for an enclosure with a vent and a single jet agree with the experimental data within a margin of about 10% for jet flow rates ranging from 1.21 × 10⁻⁴ to 3.29 × 10⁻⁴ m³/s. In conclusion, computing time for each BMIX++ model with a normal desktop computer is less than 5 min.« less

Rotational motion of elongated particles in isotropic turbulent flow: statistical perspective

NASA Astrophysics Data System (ADS)

Zhao, Lihao; Andersson, Helge; Variano, Evan

2014-11-01

We consider the rotational motion of non-spherical particles in turbulent flow, comparing the statistics of particles' angular velocity to the corresponding quantities computed in the fluid phase. We use numerical (DNS) and laboratory measurements for particles that are both larger and smaller than the Kolmogorov lengthscale. The particles are spheroids or rods, with aspect ratios between 1 and 10. We will discuss the subtleties of defining a meaningful Stokes number for these particles, focusing on the effect of asphericity and the fact that our interest is in rotation and not translation. Comparing the probability density function of angular velocity between fluid and particle phase indicates that the angular velocity of particles has a narrower distribution than that of the fluid phase, and that. particles do respond to extreme events in the fluid phase. The first four moments of the PDFs are analyzed, and these show that the ``filtering'' effect is very similar between DNS and lab experiments, despite differences in particle sizes and mass. We propose a nondimensional curve for predicting the magnitude of the filtering effect, and discuss the implications of this curve for the definition of Stokes number, as discussed earlier. This work has been supported by grants from the Peder Sather Center for Advanced Study at UC Berkeley and from the Research Council of Norway (Contract No. 213917/F20).

Bolometric Array Detectors for Space-Borne Astronomy

NASA Technical Reports Server (NTRS)

Lange, Andrew E.

2000-01-01

Funding from the NASA Innovative Research Grant was used to develop bolometric detectors. As described in the proposal, silicon nitride micromesh ('spider-web') absorbers had been demonstrated at U.C. Berkeley but not developed to be flight-worthy devices. We proceeded to first fabricate bolometers with Neutron Transmutation Doped (NTD) Ge thermistors that demonstrated high optical coupling (Church et al. 1996) and were developed for a ground-based millimeter-wave receiver (Mauskopf et al. 1997). The next generation of devices used In bump-bonded thermistors to achieve devices with performance product NEP*sqrt(tau) = 3e - 18 j at 300 mK, demonstrating a full order of magnitude improvement over pervious devices. These devices achieved an NEP = 1e-18 W/rtHz (Murray et al. 1996) as promised in the proposal. Sensitivities as good as 1e - 19 W/rtHz appear achievable with the silicon nitride architecture (Bock et al. 1997). Finally, arrays of micromesh bolometers were shown to be feasible in the last year of the program by etching a large number of devices on a single silicon wafer (75 mm). Full arrays were subsequently demonstrated for selection on the ESA/NASA Far-Infrared Space Telescope (FIRST) in competition with detectors provided by CEA in France and GSFC in the US Micromesh bolometer arrays are now baselined for both the ESA/NASA Planck and FIRST missions.

The Grinnell Project; Small Mammal Responses to Climate in California

NASA Astrophysics Data System (ADS)

Conroy, C. C.; Koo, M.; Monahan, B.; Parra, J.; Moritz, C.

2006-12-01

Between 1915 and 1920, Joseph Grinnell and colleagues investigated the diversity of mammals, reptiles, amphibians and birds across what they termed the Yosemite Transect, an area spanning portions of the San Joaquin Valley, the Sierra Nevada, including about 1/3 of Yosemite National Park, and ending at Mono Lake. Their data collection included preservation of series of specimens at a large number of locations, point counts of birds, photography and extensive natural history notes, all of which are still archived at the Museum of Vertebrate Zoology at UC Berkeley. Beginning in 2003, researchers from the MVZ began retracing this work, collecting specimens, using point counts, and retaking some photographs. The comparison of the two periods indicates that some mammals have shifted their ranges greatly. Most taxa show an elevation increase, either an increase at the top for middle elevation species, or a retraction at the bottom for higher elevation species. However, not all species moved, and one high elevation species moved down. To further investigate how changes observed in Yosemite might also apply to larger spatial scales, our group has been using historic climate surfaces, historic specimen localities, and a variety of modeling methods to predict statewide changes in species' distributions. Other potential sites to be revisited include the Lassen Transect in Northern California, the Colorado River, and the San Bernardino Mountains.

Investigation into Practical Implementations of a Zero Knowledge Protocol.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marleau, Peter; Krentz-Wee, Rebecca E.

In recent years, the concept of Zero Knowledge Protocols (ZKP) as a useful approach to nuclear warhead verification has become increasingly popular. Several implementations of ZKP have been proposed, driving technology development toward proof of concept demonstrations. Whereas proposed implementations seem to fall within the general class of template-based techniques, all physical implementations of ZKPs proposed to date have a complication: once the instrumentation is prepared, it is no longer authenticatable; the instrument physically contains sensitive information. In this work we explore three different concepts that may offer more authenticatable and practical ZKP implementations and evaluate the sensitive information thatmore » may be at risk when doing so: sharing a subset of detector counts in a preloaded image (with spatial information removed), real-time image subtraction, and a new concept, CONfirmation using a Fast-neutron Imaging Detector with Anti-image NULL-positive Time Encoding (CONFIDANTE). CONFIDANTE promises to offer an almost ideal implementation of ZKP: a positive result is indicated by a constant rate at all times enabling the monitoring party the possibility of full access to the instrument before, during, and after confirmation. A prototype of CONFIDANTE was designed, built, and its performance evaluated in a series of measurements of several objects including a set of plutonium dioxide Hemispheres. Very encouraging results proving feasibility are presented. 1 Rebecca is currently a graduate student in Nuclear Engineering at UC Berkeley« less

Summary of Internship Experience for 2010 DHS/ORISE summer program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pusateri, Elise; Descalle, Marie-Anne

2010-08-13

The U.S. Department of Homeland Security has deemed as a threat to national security the possibility of fissionable materials being concealed in intermodal cargo containers. Detecting these materials is critical to preventing nuclear proliferation and terrorism. Thus, several high-energy photon-based imaging applications are being developed to detect materials with Z>72 in such containers. In an initial study, an array made of plastic scintillator material was considered for a detector in combination with a bremsstrahlung sources. While plastic is a practical and cheap material to use, it has relatively poor energy resolution. When studying the full spectrum of available materials, Bimore » 4Ge 3O 12 (BGO) 2 was considered and was eventually chosen as the scintillation material for its high mass density which permits high spatial resolution with reasonable detection efficiency. The final geometry of the detector chosen by UC Berkeley and Lawrence Livermore National Laboratory was an 8-by-8 array of 0.5-cm-by- 0.5-cm-by-5-cm Bi 4Ge 3O 12 (BGO) crystals, with pixels shielded by 1-mm of lead. The purpose of my research was to model the detector response using MCNP, a Monte Carlo3 code to demonstrate its expected sensitivity and ability to generate images, under conditions that could be tested experimentally and to determine the lowest energy threshold applicable.« less

WARP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergmann, Ryan M.; Rowland, Kelly L.

2017-04-12

WARP, which can stand for ``Weaving All the Random Particles,'' is a three-dimensional (3D) continuous energy Monte Carlo neutron transport code developed at UC Berkeley to efficiently execute on NVIDIA graphics processing unit (GPU) platforms. WARP accelerates Monte Carlo simulations while preserving the benefits of using the Monte Carlo method, namely, that very few physical and geometrical simplifications are applied. WARP is able to calculate multiplication factors, neutron flux distributions (in both space and energy), and fission source distributions for time-independent neutron transport problems. It can run in both criticality or fixed source modes, but fixed source mode is currentlymore » not robust, optimized, or maintained in the newest version. WARP can transport neutrons in unrestricted arrangements of parallelepipeds, hexagonal prisms, cylinders, and spheres. The goal of developing WARP is to investigate algorithms that can grow into a full-featured, continuous energy, Monte Carlo neutron transport code that is accelerated by running on GPUs. The crux of the effort is to make Monte Carlo calculations faster while producing accurate results. Modern supercomputers are commonly being built with GPU coprocessor cards in their nodes to increase their computational efficiency and performance. GPUs execute efficiently on data-parallel problems, but most CPU codes, including those for Monte Carlo neutral particle transport, are predominantly task-parallel. WARP uses a data-parallel neutron transport algorithm to take advantage of the computing power GPUs offer.« less

A Context Menu for the Real World: Controlling Physical Appliances Through Head-Worn Infrared Targeting

DTIC Science & Technology

2013-12-10

Edward A. Lee Björn Hartmann Electrical Engineering and Computer Sciences University of California at Berkeley Technical Report No. UCB/EECS-2013-200...NAME(S) AND ADDRESS(ES) University of California at Berkeley, Electrical Engineering and Computer Sciences,Berkeley,CA,94720 8. PERFORMING...movement. PHYSICAL TARGET ACQUISITION STUDY To understand the accuracy and performance of head- orientation-based selection through our device, we car - ried

A Context Menu for the Real World: Controlling Physical Appliances through Head-Worn Infrared Targeting

DTIC Science & Technology

2013-11-04

Edward A. Lee Björn Hartmann Electrical Engineering and Computer Sciences University of California at Berkeley Technical Report No. UCB/EECS-2013-182...NAME(S) AND ADDRESS(ES) University of California at Berkeley, Electrical Engineering and Computer Sciences,Berkeley,CA,94720 8. PERFORMING...accuracy and performance of head- orientation-based selection through our device, we car - ried out a comparative target acquisition study, where

Sit Down with Sabin: Margaret Torn: The Carbon Cycle Like You've Never Seen It (LBNL Summer Lecture Series)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, Sabin; Torn, Margaret

2011-07-06

Lawrence Berkeley National Laboratory soil scientist Margaret Torn appears July 6, 2011 on "Sit Down with Sabin," a weekly conversation in which former reporter Sabin Russell chats with Berkeley Lab staff about innovative science. Torn discusses how she travels the world to learn more about soil's huge role in the global carbon cycle. Brought to you by Berkeley Lab Public Affairs.

An introduction to the nitrogen dynamics in controlled systems workshop. Life support and nitrogen: NASA's interest in nitrogen cycling

NASA Technical Reports Server (NTRS)

MacElroy, R. D.; Smernoff, D. T.

1996-01-01

A Workshop on "Nitrogen Dynamics in Controlled Systems" was held September 26-28, 1995 at the Lawrence Berkeley National Laboratory. The meetings were sponsored by the NASA Advanced Life Support program and the Lawrence Berkeley National Laboratory, and hosted by Prof. Lester Packer of the University of California at Berkeley, and of the Lawrence Berkeley National Laboratory. The Workshop participants were asked to: 1. summarize current knowledge on the cycling of nitrogen in closed systems; 2. identify the needs that closed systems may have for specific forms of nitrogen; 3. identify possible ways of generating and maintaining (or avoiding) specific forms and concentrations of nitrogen; 4. compare biological and physical/chemical methods of transforming nitrogen.

Ionic liquid dependence of triplet-sensitized photon upconversion.

PubMed

Murakami, Yoichi; Ito, Toshiyuki; Kawai, Akio

2014-12-11

Photon upconversion (UC) is a technology used to convert wasted lower energy photons to usable higher energy photons. Triplet-sensitized UC based on the triplet-triplet annihilation (TTA) of organic molecules has recently received attention because of its applicability to noncoherent sunlight. Among the various media proposed for this UC, ionic liquids (ILs) are practically advantageous because of their nonvolatility and nonflammability. However, from previous studies, the efficiency of UC (ΦUC) has been found to depend on the ILs employed. In this article, systematic investigations were carried out on samples made using more than 10 kinds of ILs, all of which were purified before sample fabrication to enhance data reliability. Several clear tendencies were found, and they were all related to the viscosity of the ILs. We also found that the magnitude of their solvatochromic shifts did not correlate to these trends. These results show that the dynamic aspects of the molecules influence the kinetics that govern the magnitude of ΦUC. Along with related discussions and interpretations, these results should provide a guideline toward increasing the ΦUC.

Intelligent Agents as a Basis for Natural Language Interfaces

DTIC Science & Technology

1988-01-01

language analysis component of UC, which produces a semantic representa tion of the input. This representation is in the form of a KODIAK network (see...Appendix A). Next, UC’s Concretion Mechanism performs concretion inferences ([Wilensky, 1983] and [Norvig, 1983]) based on the semantic network...The first step in UC’s processing is done by UC’s parser/understander component which produces a KODIAK semantic network representa tion of

Clonal Evolution of Chemotherapy-resistant Urothelial Carcinoma

PubMed Central

Faltas, Bishoy M.; Prandi, Davide; Tagawa, Scott T.; Molina, Ana M.; Nanus, David M.; Sternberg, Cora; Rosenberg, Jonathan; Mosquera, Juan Miguel; Robinson, Brian; Elemento, Olivier; Sboner, Andrea; Beltran, Himisha; Demichelis, Francesca; Rubin, Mark A.

2017-01-01

Chemotherapy-resistant urothelial carcinoma (UC) has no uniformly curative therapy. Understanding how selective pressure from chemotherapy directs UC’s evolution and shapes its clonal architecture is a central biological question with clinical implications. To address this question, we performed whole-exome sequencing and clonality analysis of 72 UCs including 16 matched sets of primary and advanced tumors prospectively collected before and after chemotherapy. Our analysis provided several insights: (i) chemotherapy-treated UC is characterized by intra-patient mutational heterogeneity and the majority of mutations are not shared, (ii) both branching evolution and metastatic spread are very early events in the natural history of UC; (iii) chemotherapy-treated UC is enriched with clonal mutations involving L1-cell adhesion molecule (L1CAM) and integrin signaling pathways; (iv) APOBEC induced-mutagenesis is clonally-enriched in chemotherapy-treated UC and continues to shape UC’s evolution throughout its lifetime. PMID:27749842

Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis.

PubMed

Wang, Chunyan; Tang, Xudong; Zhang, Li

2017-01-01

Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available. Here we aim to review our current understanding of HQT and its ingredients in treating UC and how the agents modulate the main pathogenesis of the disease, including the intestinal environment, immune imbalance, inflammatory pathways, and oxidative stress. The summary on this issue may provide better understanding of HQT and its ingredients in treating UC and possibly help in promoting its clinical application.

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo.

PubMed

Levinger, I; Lin, X; Zhang, X; Brennan-Speranza, T C; Volpato, B; Hayes, A; Jerums, G; Seeman, E; McConell, G

2016-02-01

We tested whether GPRC6A, the putative receptor of undercarboxylated osteocalcin (ucOC), is present in mouse muscle and whether ucOC increases insulin sensitivity following ex vivo muscle contraction. GPPRC6A is expressed in mouse muscle and in the mouse myotubes from a cell line. ucOC potentiated the effect of ex vivo contraction on insulin sensitivity. Acute exercise increases skeletal muscle insulin sensitivity. In humans, exercise increases circulating ucOC, a hormone that increases insulin sensitivity in rodents. We tested whether GPRC6A, the putative receptor of ucOC, is present in mouse muscle and whether recombinant ucOC increases insulin sensitivity in both C2C12 myotubes and whole mouse muscle following ex vivo muscle contraction. Glucose uptake was examined in C2C12 myotubes that express GPRC6A following treatment with insulin alone or with insulin and increasing ucOC concentrations (0.3, 3, 10 and 30 ng/ml). In addition, glucose uptake, phosphorylated (p-)AKT and p-AS160 were examined ex vivo in extensor digitorum longus (EDL) dissected from C57BL/6J wild-type mice, at rest, following insulin alone, after muscle contraction followed by insulin and after muscle contraction followed by recombinant ucOC then insulin exposure. We observed protein expression of the likely receptor for ucOC, GPRC6A, in whole muscle sections and differentiated mouse myotubes. We observed reduced GPRC6A expression following siRNA transfection. ucOC significantly increased insulin-stimulated glucose uptake dose-dependently up to 10 ng/ml, in differentiated mouse C2C12 myotubes. Insulin increased EDL glucose uptake (∼30 %, p < 0.05) and p-AKT and p-AKT/AKT compared with rest (all p < 0.05). Contraction prior to insulin increased muscle glucose uptake (∼25 %, p < 0.05), p-AKT, p-AKT/AKT, p-AS160 and p-AS160/AS160 compared with contraction alone (all p < 0.05). ucOC after contraction increased insulin-stimulated muscle glucose uptake (∼12 % p < 0.05) and p-AS160 (<0.05) more than contraction plus insulin alone but without effect on p-AKT. In the absence of insulin and/or of contraction, ucOC had no significant effect on muscle glucose uptake. GPRC6A, the likely receptor of osteocalcin (OC), is expressed in mouse muscle. ucOC treatment augments insulin-stimulated skeletal muscle glucose uptake in C2C12 myotubes and following ex vivo muscle contraction. ucOC may partly account for the insulin sensitizing effect of exercise.

High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial.

PubMed

Aoun, Mabel; Makki, Maha; Azar, Hiba; Matta, Hiam; Chelala, Dania Nehme

2017-06-07

Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular calcifications. Supplementation of hemodialysis patients with vitamin K 2 (menaquinone-7) has been studied in Europe with a maximum 61% drop of dp-ucMGP levels. The aim of this study is to assess first the drop of dp-ucMGP in an Eastern Mediterranean cohort after vitamin K 2 treatment and second the correlation between baseline dp-ucMGP and vascular calcification score. This is a prospective, pre-post intervention clinical trial involving 50 hemodialysis patients who received daily 360 μg of menaquinone-7 for 4 weeks. At baseline they were assessed for plasma dp-ucMGP levels and vascular calcification scores (AC-24) as well as for other demographic, clinical and biological variables. Dp-ucMGP levels were measured a second time at 4 weeks. At baseline, dp-ucMGP levels were extremely elevated with a median of 3179.15 (1825.25; 4339.50) pM and correlated significantly with AC-24 (Spearman's rho = 0.43, P = 0.002). Using a bivariate regression analysis, the association between dp-ucMGP levels and AC-24 was most significant when comparing dp-ucMGP levels less than 1000 to those more than 1000 pM (P = 0.02). Dp-ucMGP levels higher than 5000 pM were significantly associated with females, patients with recent fracture and patients with lower serum albumin (respectively P = 0.02, 0.004 and 0.046). The average drop of dp-ucMGP at 4 weeks of treatment was found to be 86% with diabetics having the lowest drop rate (P = 0.01). Vitamin K deficiency, as assessed by high dp-ucMGP levels, is profound in hemodialysis patients from the Eastern Mediterranean region and it is significantly correlated with vascular calcifications. Daily 360 μg of menaquinone-7, given for 4 weeks, effectively reduces dp-ucMGP in this population. Future studies are needed to assess the changes in vascular calcifications in hemodialysis patients treated with vitamin K 2 over a longer follow-up period. The clinical trial was registered on clinicaltrials.gov (Identification number NCT02876354 , on August 11, 2016).

Combination of Azathioprine and Aminosalicylate Treatment Prevent Risk of Cardiovascular Disease in Women with Ulcerative Colitis by Reducing Inflammation.

PubMed

dos Santos, Lana Claudinez; Costa, Aline Villela; Lopes, Lorrayne Gonçalves; Leonel, Alda Jusceline; Aguilar, Edenil Costa; Noviello, Maria de Lourdes Meirelles; Ferrari, Maria de Lourdes de Abreu; Alvarez-Leite, Jacqueline I

2015-08-07

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with involvement of the immune system. Chronic inflammatory diseases have been associated with increased risk of cardiovascular disease (CVD) but few studies have assessed this risk in patients with UC and the influence of drug treatment. Thus, we evaluated the risk of development of CVD in women with UC in clinical remission, considering the drug treatment. Twenty-one women with UC participated in this study: 12 used aminosalicylates (ASA group) and 9 used azathioprine added to aminosalicylates (AZA+ASA group). The healthy control group was matched for age. We evaluated blood pressure, body composition, and biochemical and immunological parameters. Compared to the respective control group, the UC groups showed expansion of body fat and less lean body mass. Blood pressure, pro-inflammatory cytokines, nitric oxide, C reactive protein, erythrocyte sedimentation rate (ESR), and anti-oxidized LDL antibodies were higher in UC groups. Only AZA+ASA group showed increased anti-inflammatory cytokines (IL-10 and TGF-β). Framingham scores showed higher risk of CVD in UC groups. UC groups were compared and women treated with azathioprine showed reduction of total protein, globulin, ESR, and lymphocytes, with increased IL-6, TNF, IL-10, and TGF-β. Our data suggest that women with UC in clinical remission have a higher risk for development of atherosclerosis and CVD when compared to the control group, while women treated with azathioprine seem more protected than those treated only with aminosalicylates, due to better regulation of the inflammatory process.

Individual health discount rate in patients with ulcerative colitis.

PubMed

Waljee, Akbar K; Morris, Arden M; Waljee, Jennifer F; Higgins, Peter D R

2011-06-01

In cost-effectiveness analysis, discount rates are used in calculating the value of future costs and benefits. However, standard discount rates may not accurately describe the decision-making of patients with ulcerative colitis (UC). These patients often choose the long-term risks of immunosuppressive therapy over the short-term risks of colectomy, demonstrating very high discount rates for future health. In this study we aimed to measure the discount rate in UC patients and identify variables associated with the discount rate. We surveyed patients with UC and patients who were postcolectomy for UC to measure their valuations of UC and colectomy health states. We used Standard Gamble (SG) and Time-Trade-Off (TTO) methods to assess current and future health state valuations and calculated the discount rate. Participants included 150 subjects with UC and 150 subjects who were postcolectomy for UC. Adjusted discount rates varied widely (0%-100%), with an overall median rate of 55.0% (interquartile range [IQR] 20.6-100), which was significantly higher than the standard rate of 5%. Within the normal range of discount rates, patients' expected discount rate increased by 0.80% for each additional year of age, and female patients had discount rates that averaged ≈ 8% less than their age-matched counterparts and approached statistical significance. The accepted discount rate of 5% grossly underestimates UC patients' preference for long-term over short-term risk. This might explain UC patients' frequent choice of the long-term risks of immunosuppressive medical therapy over the short-term risks of colectomy. Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.

[Clinical analysis of cutaneous manifestations and related factors in patients with ulcerative colitis].

PubMed

Tian, Y; Li, J X; Wang, H H; Li, R Y; Liu, X G

2016-07-01

To investigate the cutaneous manifestations in patients with ulcerative colitis (UC) and related factors. Patients admitted to Department of Gastroenterology Peking University First Hospital from January 1994 to December 2014 and diagnosed as UC were retrospectively enrolled in this study. Skin disorders were confirmed by the dermatologists. Clinical data were collected and compared between patients with and without cutaneous manifestations. Among the total 373 UC patients, there were 34 cases (9.1%) with cutaneous manifestations, including 11 pyoderma gangrenosum, 8 erythema nodosum, 6 eczema, 3 psoriasis, 2 pemphigus, 1 granulomatous cheilitis, 1 ichthyosis, 1 acne rosacea, and 1 impetigo. The skin manifestations may occur after the diagnosis, simultaneously or even before the diagnosis of UC, which were 24, 7 and 3 patients respectively. The mean age in patients with skin lesions was (47.2±12.1) years, male to female ratio 0.79∶1. More patients with skin manifestations had severe activity of UC compared with non-skin group [50.0%(17/34) vs 25.1%(85/339), P=0.01]. In addition, the proportion of extensive colitis in skin lesion group was significantly higher than that in non-skin group [76.5%(26/34) vs 54.6%(185/339), P=0.04]. The cutaneous manifestations associated with UC are polymorphic, erythema nodosums and pyoderma gangrenosums are the most common skin lesions seen in UC patients. Skin lesions occur concurrently, pre or post the diagnosis of UC. Skin lesions in UC patients suggest more severe disease activity. Clinicians need to pay more attention to this group.

Gene-Gene and Gene-Environment Interactions in Ulcerative Colitis

PubMed Central

Wang, Ming-Hsi; Fiocchi, Claudio; Zhu, Xiaofeng; Ripke, Stephan; Kamboh, M. Ilyas; Rebert, Nancy; Duerr, Richard H.; Achkar, Jean-Paul

2014-01-01

Genome-wide association studies (GWAS) have identified at least 133 ulcerative colitis (UC) associated loci. The role of genetic factors in clinical practice is not clearly defined. The relevance of genetic variants to disease pathogenesis is still uncertain because of not characterized gene-gene and gene-environment interactions. We examined the predictive value of combining the 133 UC risk loci with genetic interactions in an ongoing inflammatory bowel disease (IBD) GWAS. The Wellcome Trust Case-Control Consortium (WTCCC) IBD GWAS was used as a replication cohort. We applied logic regression (LR), a novel adaptive regression methodology, to search for high order interactions. Exploratory genotype correlations with UC sub-phenotypes (extent of disease, need of surgery, age of onset, extra-intestinal manifestations and primary sclerosing cholangitis (PSC)) were conducted. The combination of 133 UC loci yielded good UC risk predictability (area under the curve [AUC] of 0.86). A higher cumulative allele score predicted higher UC risk. Through LR, several lines of evidence for genetic interactions were identified and successfully replicated in the WTCCC cohort. The genetic interactions combined with the gene-smoking interaction significantly improved predictability in the model (AUC, from 0.86 to 0.89, P=3.26E-05). Explained UC variance increased from 37% to 42% after adding the interaction terms. A within case analysis found suggested genetic association with PSC. Our study demonstrates that the LR methodology allows the identification and replication of high order genetic interactions in UC GWAS datasets. UC risk can be predicted by a 133 loci and improved by adding gene-gene and gene-environment interactions. PMID:24241240

YouTube as an educational tool regarding male urethral catheterization.

PubMed

Nason, Gregory J; Kelly, Padraig; Kelly, Michael E; Burke, Matthew J; Aslam, Asadullah; Giri, Subhasis K; Flood, Hugh D

2015-04-01

Urethral catheterization (UC) is a common procedure carried out on a daily basis. The aims of this study were to assess the quality of YouTube as an educational tool regarding male UC and to assess the experience of newly qualified doctors regarding UC. YouTube was searched for videos containing relevant information about male UC. A checklist for evaluating content for male UC was devised. The top-ranked video was shown to interns and they were questioned regarding their experience of UC and the usefulness of the video. A total of 100 videos was screened and 49 unique videos were identified. The median length of video was 7 min 15 s (range 1 min 44 s to 26 min 44 s). Regarding the Safe Catheter Insertion Score, the mean score was 5.18 ± 1.64. 9 (18.4%) deemed useful, 24 (49%) somewhat useful and 16 (32.7%) not useful. There was no difference in the number of views (p = 0.487), duration of video (p = 0.364) or number of days online (p = 0.123) between those categorized as useful, somewhat useful and not useful. Twenty-six interns (89.7%) attended the UC teaching session. All reported the video to be a useful educational adjunct. Nine of the respondents (42.9%) had independently inserted a urinary catheter before the educational session. The quality of videos on YouTube regarding male UC is widely variable. Preselected videos are deemed useful by junior doctors regarding male UC and can be used as an educational adjunct before performing hands-on tasks.

Telocytes are reduced during fibrotic remodelling of the colonic wall in ulcerative colitis

PubMed Central

Manetti, Mirko; Rosa, Irene; Messerini, Luca; Ibba-Manneschi, Lidia

2015-01-01

Ulcerative colitis (UC) is characterized by chronic relapsing intestinal inflammation finally leading to extensive tissue fibrosis and resulting in a stiff colon unable to carry out peristalsis or to resorb fluids. Telocytes, a peculiar type of stromal cells, have been recently identified in the human gastrointestinal tract. Several roles have been proposed for telocytes, including mechanical support, intercellular signalling and modulation of intestinal motility. The aim of the present work was to investigate the presence and distribution of telocytes in colonic specimens from UC patients compared with controls. Archival paraffin-embedded samples of the left colon from UC patients who underwent elective bowel resection and controls were collected. Tissue sections were stained with Masson's trichrome to detect fibrosis. Telocytes were identified by CD34 immunohistochemistry. In early fibrotic UC cases, fibrosis affected the muscularis mucosae and submucosa, while the muscularis propria was spared. In advanced fibrotic UC cases, fibrosis extended to affect the muscle layers and the myenteric plexus. Few telocytes were found in the muscularis mucosae and submucosa of both early and advanced fibrotic UC colonic wall. In the muscle layers and myenteric plexus of early fibrotic UC, telocytes were preserved in their distribution. In the muscularis propria of advanced fibrotic UC, the network of telocytes was reduced or even completely absent around smooth muscle bundles and myenteric plexus ganglia, paralleling the loss of the network of interstitial cells of Cajal. In UC, a loss of telocytes accompanies the fibrotic remodelling of the colonic wall and might contribute to colonic dysmotility. PMID:25283476

Randomized Trial of Family Therapy versus Non-Family Treatment for Adolescent Behavior Problems in Usual Care

PubMed Central

Hogue, Aaron; Dauber, Sarah; Henderson, Craig E.; Bobek, Molly; Johnson, Candace; Lichvar, Emily; Morgenstern, Jon

2014-01-01

Objective A major focus of implementation science is discovering whether evidence-based approaches can be delivered with fidelity and potency in routine practice. This randomized trial compared usual care family therapy (UC-FT), implemented without a treatment manual or extramural support as the standard-of-care approach in a community clinic, to non-family treatment (UC-Other) for adolescent conduct and substance use disorders. Method The study recruited 205 adolescents (mean age 15.7 years; 52% male; 59% Hispanic American, 21% African American) from a community referral network, enrolling 63% for primary mental health problems and 37% for primary substance use problems. Clients were randomly assigned to either the UC-FT site or one of five UC-Other sites. Implementation data confirmed that UC-FT showed adherence to the family therapy approach and differentiation from UC-Other. Follow-ups were completed at 3, 6, and 12 months post-baseline. Results There was no between-group difference in treatment attendance. Both conditions demonstrated improvements in externalizing, internalizing, and delinquency symptoms. However, UC-FT produced greater reductions in youth-reported externalizing and internalizing among the whole sample, in delinquency among substance-using youth, and in alcohol and drug use among substance-using youth. The degree to which UC-FT outperformed UC-Other was consistent with effect sizes from controlled trials of manualized family therapy models. Conclusions Non-manualized family therapy can be effective for adolescent behavior problems within diverse populations in usual care, and it may be superior to non-family alternatives. PMID:25496283

Validation of the "German Inflammatory Bowel Disease Activity Index (GIBDI)": An Instrument for Patient-Based Disease Activity Assessment in Crohn's Disease and Ulcerative Colitis.

PubMed

Hüppe, Angelika; Langbrandtner, Jana; Häuser, Winfried; Raspe, Heiner; Bokemeyer, Bernd

2018-05-09

 Assessment of disease activity in Crohn's disease (CD) and ulcerative colitis (UC) is usually based on the physician's evaluation of clinical symptoms, endoscopic findings, and biomarker analysis. The German Inflammatory Bowel Disease Activity Index for CD (GIBDI CD ) and UC (GIBDI UC ) uses data from patient-reported questionnaires. It is unclear to what extent the GIBDI agrees with the physicians' documented activity indices.  Data from 2 studies were reanalyzed. In both, gastroenterologists had documented disease activity in UC with the partial Mayo Score (pMS) and in CD with the Harvey Bradshaw Index (HBI). Patient-completed GIBDI questionnaires had also been assessed. The analysis sample consisted of 151 UC and 150 CD patients. Kappa coefficients were determined as agreement measurements.  Rank correlations were 0.56 (pMS, GIBDI UC ) and 0.57 (HBI, GIBDI CD ), with p < 0.001. The absolute agreement for 2 categories of disease activity (remission yes/no) was 74.2 % (UC) and 76.6 % (CD), and for 4 categories (none/mild/moderate/severe) 60.3 % (UC) and 61.9 % (CD). The kappa values ranged between 0.47 for UC (2 categories) and 0.58 for CD (4 categories).  There is satisfactory agreement of GIBDI with the physician-documented disease activity indices. GIBDI can be used in health care research without access to assessments of medical practitioners. In clinical practice, the index offers a supplementary source of information. © Georg Thieme Verlag KG Stuttgart · New York.

Bleaching effects of massecuite on some properties of crystallized sugar beet and milk chocolate bars produced.

PubMed

Sadjadi, F Seyed; Honarvar, M; Kalbasi-Ashtari, A; Motaghian, P

2018-04-01

Four kinds of bleached, unbleached, second and third crystal sugars (BCS, UCS, SCS and TCS) were made from different massecuites in a sugar-beet factory, and their physiochemical (polarization, invert sugar, colorants, pH, ash and SO 2 ), microbiological and functional properties were measured. While the polarization of UCS, SCS and TCS were lower than BCS; their invert sucrose, colorants, pH and ash contents were significantly higher than BCS. The phenols and betaine of BCS, UCS, SCS, and TCS were 144, 401, 384 and 673 (mg/100 g); and 244, 791, 4662, and 6589 (mg/100 g); respectively. Whereas the phenol of milk chocolate bars (MCB) made with UCS, SCS, and TCS were only 10% higher than MCB completed with BCS; their betaine contents were substantially (up to 16 times) higher than the ones finished with BCS. Sensory evaluation showed that the MCB prepared with three sugars including UCS, SCS and TCS had significantly higher glossiness, brittleness, flavor and mouth feel than those made with BCS. The greater colorants, ash content and inverted sugars of UCS, SCS and TCS (in comparison with BCS) made considerable improvements in the glossiness, flavor and brittleness of MCB, respectively. BCS had 8 ppm of toxic sulfur; whereas, UCS, SCS and TCS had no detectable sulfur and significantly higher beneficial copper content than BCS. No pathogenic microorganism were detected in UCS, SCS, TCS or their subsequent MCB. Our results highly recommend using UCS, SCS and TCS instead of BCS in food products (such as MCB) due to their higher health benefits.

In Conversation with Jeff Neaton

ScienceCinema

Jeff Neaton

2017-12-09

Jan. 22, 2010: Host Alice Egan of Berkeley Lab's Materials Sciences Division interviews scientists about their lives and work in language everyone can understand. Her guest Berkeley Lab's MIke Crommie.

Maximizing the Efficiency of MAGTF Airlift Capacity in WestPac

DTIC Science & Technology

2013-03-27

respectively, cover the realm of medium-long range, medium lift capabilities. The UC -35 and the UC -12 aircraft, for short-medium range, light lift...requirements, are variations similar to the Cessna Citation and Beechcraft King Air respectively. In addition, the upgraded UC -12W model possesses an...airlift are resident to the VMGR and H&HS squadrons, specifically, the KC-130 and the OSA C- 12 and UC -35 aircraft, respectively. Each of these units

A content-based image retrieval method for optical colonoscopy images based on image recognition techniques

NASA Astrophysics Data System (ADS)

Nosato, Hirokazu; Sakanashi, Hidenori; Takahashi, Eiichi; Murakawa, Masahiro

2015-03-01

This paper proposes a content-based image retrieval method for optical colonoscopy images that can find images similar to ones being diagnosed. Optical colonoscopy is a method of direct observation for colons and rectums to diagnose bowel diseases. It is the most common procedure for screening, surveillance and treatment. However, diagnostic accuracy for intractable inflammatory bowel diseases, such as ulcerative colitis (UC), is highly dependent on the experience and knowledge of the medical doctor, because there is considerable variety in the appearances of colonic mucosa within inflammations with UC. In order to solve this issue, this paper proposes a content-based image retrieval method based on image recognition techniques. The proposed retrieval method can find similar images from a database of images diagnosed as UC, and can potentially furnish the medical records associated with the retrieved images to assist the UC diagnosis. Within the proposed method, color histogram features and higher order local auto-correlation (HLAC) features are adopted to represent the color information and geometrical information of optical colonoscopy images, respectively. Moreover, considering various characteristics of UC colonoscopy images, such as vascular patterns and the roughness of the colonic mucosa, we also propose an image enhancement method to highlight the appearances of colonic mucosa in UC. In an experiment using 161 UC images from 32 patients, we demonstrate that our method improves the accuracy of retrieving similar UC images.

Clinical and economic outcomes in a population-based European cohort of 948 ulcerative colitis and Crohn's disease patients by Markov analysis.

PubMed

Odes, S; Vardi, H; Friger, M; Esser, D; Wolters, F; Moum, B; Waters, H; Elkjaer, M; Bernklev, T; Tsianos, E; O'Morain, C; Stockbrügger, R; Munkholm, P; Langholz, E

2010-04-01

Forecasting clinical and economic outcomes in ulcerative colitis (UC) and Crohn's disease (CD) patients is complex, but necessary. To determine: the frequency of treatment-classified clinical states; the probability of transition between states; and the economic outcomes. Newly diagnosed UC and CD patients, allocated into seven clinical states by medical and surgical treatments recorded in serial 3-month cycles, underwent Markov analysis. Over 10 years, 630 UC and 318 CD patients had 22,823 and 11,871 cycles. The most frequent clinical outcomes were medical/surgical remission (medication-free) and mild disease (on 5-aminosalicylates, antibiotics, topical corticosteroids), comprising 28% and 62% of UC cycles and 24% and 51% of CD cycles respectively. The probability of drug-response in patients receiving systemic corticosteroids/immunomodulators was 0.74 in UC, 0.66 in CD. Both diseases had similar likelihood of persistent drug-dependency or drug-refractoriness. Surgery was more probable in CD, 0.20, than UC, 0.08. In terms of economic outcomes, surgery was costlier in UC per cycle, but the outlay over 10 years was greater in CD. Drug-refractory UC and CD cases engendered high costs in the cohort. Most patients on 5-aminosalicylates, corticosteroids and immunomodulators had favourable clinical and economic outcomes over 10 years. Drug-refractory and surgical patients exhibited greater long-term expenses.

Recent advances in enhanced luminescence upconversion of lanthanide-doped NaYF4 phosphors

NASA Astrophysics Data System (ADS)

Kumar, Deepak; Verma, Kartikey; Verma, Shefali; Chaudhary, Babulal; Som, Sudipta; Sharma, Vishal; Kumar, Vijay; Swart, Hendrik C.

2018-04-01

NaYF4 is regarded as the best upconversion (UC) matrix owing to its low phonon energy, more chemical stability, and a superior refractive index. This review reports on the various synthesis techniques of lanthanide-doped NaYF4 phosphors for UC application. The UC intensity depends on different properties of the matrix and those are discussed in detail. Plasmon-enhanced luminescence UC of the lanthanide-doped NaYF4 core-shells structure is discussed based on a literature survey. The present review provides the information about how the UC intensity can be enhanced. The idea about the UC is then deliberately used for versatile applications such as luminescent materials, display devices, biomedical imaging and different security appliances. In addition, the present review demonstrates the recent trends of NaYF4 UC materials in solar cell devices. The role of NaYF4 phosphor to eradicate the spectral variance among the incident solar spectrum, semiconductor as well as the sub-band gap nature of the semiconductor materials is also discussed in detail. Considering the fact that the research status on NaYF4 phosphor for photovoltaic application is now growing, the present review is therefore very important to the researchers. More importantly, this may promote more interesting research platforms to investigate the realistic use of UC nanophosphors as spectral converters for solar cells.

Extension and flexion in the upper cervical spine in neck pain patients.

PubMed

Ernst, Markus J; Crawford, Rebecca J; Schelldorfer, Sarah; Rausch-Osthoff, Anne-Kathrin; Barbero, Marco; Kool, Jan; Bauer, Christoph M

2015-08-01

Neck pain is a common problem in the general population with high risk of ongoing complaints or relapses. Range of motion (ROM) assessment is scientifically established in the clinical process of diagnosis, prognosis and outcome evaluation in neck pain. Anatomically, the cervical spine (CS) has been considered in two regions, the upper and lower CS. Disorders like cervicogenic headache have been clinically associated with dysfunctions of the upper CS (UCS), yet ROM tests and measurements are typically conducted on the whole CS. A cross-sectional study assessing 19 subjects with non-specific neck pain was undertaken to examine UCS extension-flexion ROM in relation to self-reported disability and pain (via the Neck Disability Index (NDI)). Two measurement devices (goniometer and electromagnetic tracking) were employed and compared. Correlations between ROM and the NDI were stronger for the UCS compared to the CS, with the strongest correlation between UCS flexion and the NDI-headache (r = -0.62). Correlations between UCS and CS ROM were fair to moderate, with the strongest correlation between UCS flexion and CS extension ROM (r = -0.49). UCS flexion restriction is related to headache frequency and intensity. Consistency and agreement between both measurement systems and for all tests was high. The results demonstrate that separate UCS ROM assessments for extension and flexion are useful in patients with neck pain. Copyright © 2014 Elsevier Ltd. All rights reserved.

Undercarboxylated osteocalcin is associated with insulin resistance, but not adiponectin, during pregnancy.

PubMed

Srichomkwun, Panudda; Houngngam, Natnicha; Pasatrat, Sophitsachi; Tharavanij, Thipaporn; Wattanachanya, Lalita; Khovidhunkit, Weerapan

2016-07-01

In mice, undercarboxylated osteocalcin (ucOC) improves beta-cell function and insulin sensitivity through adiponectin. In humans, levels of total osteocalcin (OC) and ucOC were negatively correlated with insulin resistance (IR) indices in patients with type 2 diabetes. Whether ucOC plays a role in glucose homeostasis and whether its effect is mediated through adiponectin during pregnancy is unclear. Serum levels of total OC, ucOC, and adiponectin were measured in 130 pregnant women with varying degrees of IR [gestational diabetes mellitus (GDM), n = 74 and non-GDM, n = 56]. In all participants, total OC and ucOC levels were positively correlated with HOMA-IR and HOMA-%B, and negatively correlated with QUICKI. In contrast, adiponectin levels were negatively correlated with HOMA-IR and positively correlated with QUICKI (P < 0.01, both). However, neither total OC nor ucOC was associated with adiponectin. Although none of these markers could help distinguish women with and without GDM, total OC and ucOC levels were significantly higher in non-GDM women who had 1 abnormal OGTT value than those who had all normal OGTT values. Total OC and ucOC levels were significantly correlated with insulin secretion and IR indices, but not adiponectin levels, in pregnant women. Changes in OC might be a sensitive response to increased IR during pregnancy, which was not mediated through adiponectin.

Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.

PubMed

Reissig, Kathrin; Silver, Andrew; Hartig, Roland; Schinlauer, Antje; Walluscheck, Diana; Guenther, Thomas; Siedentopf, Sandra; Ross, Jochen; Vo, Diep-Khanh; Roessner, Albert; Poehlmann-Nitsche, Angela

2017-01-01

Dysregulation of c-Jun N -terminal kinase (JNK) activation promoted DNA damage response bypass and tumorigenesis in our model of hydrogen peroxide-associated ulcerative colitis (UC) and in patients with quiescent UC (QUC), UC-related dysplasia, and UC-related carcinoma (UC-CRC), thereby adapting to oxidative stress. In the UC model, we have observed features of oncogenic transformation: increased proliferation, undetected DNA damage, and apoptosis resistance. Here, we show that Chk1 was downregulated but activated in the acute and quiescent chronic phases. In both phases, Chk1 was linked to DNA damage response bypass by suppressing JNK activation following oxidative stress, promoting cell cycle progression despite DNA damage. Simultaneously, activated Chk1 was bound to chromatin. This triggered histone acetylation and the binding of histone acetyltransferases and transcription factors to chromatin. Thus, chromatin-immobilized activated Chk1 executed a dual function by suppressing DNA damage response and simultaneously inducing chromatin modulation. This caused undetected DNA damage and increased cellular proliferation through failure to transmit the appropriate DNA damage signal. Findings in vitro were corroborated by chromatin accumulation of activated Chk1, Ac-H3, Ac-H4, and c-Jun in active UC (AUC) in vivo. Targeting chromatin-bound Chk1, GCN5, PCAF, and p300/CBP could be a novel therapeutic strategy to prevent UC-related tumor progression.

Molecular profiling of mucosal tissue associated microbiota in patients manifesting acute exacerbations and remission stage of ulcerative colitis.

PubMed

Walujkar, Sandeep A; Kumbhare, Shreyas V; Marathe, Nachiket P; Patangia, Dhrati V; Lawate, Parimal S; Bharadwaj, Renu S; Shouche, Yogesh S

2018-05-23

Dysbiosis of intestinal microflora has been postulated in ulcerative colitis (UC), which is characterized by imbalance of mucosal tissue associated bacterial communities. However, the specific changes in mucosal microflora during different stages of UC are still unknown. The aim of the current study was to investigate the changes in mucosal tissue associated microbiota during acute exacerbations and remission stages of UC. The mucosal microbiota associated with colon biopsy of 12 patients suffering from UC (exacerbated stage) and the follow-up samples from the same patients (remission stage) as well as non-IBD subjects was studied using 16S rRNA gene-based sequencing and quantitative PCR. The total bacterial count in patients suffering from exacerbated phase of UC was observed to be two fold lower compared to that of the non-IBD subjects (p = 0.0049, Wilcox on matched-pairs signed rank tests). Bacterial genera including Stenotrophomonas, Parabacteroides, Elizabethkingia, Pseudomonas, Micrococcus, Ochrobactrum and Achromobacter were significantly higher in abundance during exacerbated phase of UC as compared to remission phase. The alterations in bacterial diversity with an increase in the abnormal microbial communities signify the extent of dysbiosis in mucosal microbiota in patients suffering from UC. Our study helps in identifying the specific genera dominating the microbiota during the disease and thus lays a basis for further investigation of the possible role of these bacteria in pathogenesis of UC.

In Conversation with Mike Crommie

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mike Crommie

2010-02-16

Dec. 9 2009: Host Alice Egan of Berkeley Lab's Materials Sciences Division interviews scientists about their lives and work in language everyone can understand. Her guest is Berkeley Lab's Mike Crommie.

In Conversation with Mike Crommie

ScienceCinema

Mike Crommie

2017-12-09

Dec. 9 2009: Host Alice Egan of Berkeley Lab's Materials Sciences Division interviews scientists about their lives and work in language everyone can understand. Her guest is Berkeley Lab's Mike Crommie.

Do pure squamous cell carcinomas and urothelial carcinomas have similar prognosis after radical cystectomy?

PubMed

Balci, Ugur; Ozer, Kutan; Gorgel, Sacit Nuri; Sefik, Ertugrul; Girgin, Cengiz; Dincel, Cetin

2013-10-01

The purpose of this study was to evaluate the surgical treatment results of urothelial carcinoma (UC) and pure squamous cell carcinoma of the bladder (SCC). The records of 460 patients who have undergone radical cystectomy in our department between the years 1991 and 2011 were analyzed retrospectively, and 364 patients with UC and 60 patients with pure SCC were evaluated. Average ages of the patients with UC and SCC were 61.12 ± 8.9 and 59.38 ± 8.6 years, respectively (p = 0.902). UC group had 29 female patients, whereas SCC group had 9 female patients (p = 0.077). The mean follow-up periods were 26.09 ± 24.75 months for UC group and 22.23 ± 31.01 months for SCC group (p = 0.805). The incidence of organ-confined, extravesical, lymph node-positive diseases in UC and SCC cases was 48.9 and 32.2, 29.3 and 32.2 %, 21.8 and 35.6 %, respectively (p = 0.028). Five-year disease-specific survival (DSS) rates were 57.5 % in UC and 39.1 % in SCC group (p = 0.011). Five-year DSS rates were 81.2 % in UC and 75.0 % in SCC group in organ-confined disease (p = 0.534) and 28.2 % in UC and 40.9 % in SCC group in extravesical disease (p = 0.845). In lymph node-positive patients, DSS time was 20.9 ± 2.85 months in UC and 12.8 ± 2.07 months in SCC patients (p = 0.182). In multivariate analysis, pT stage (HR: 2.221; 95 % CI: 1.695-2.911) and lymph node involvement (HR: 2.863; 95 % CI: 1.819-4.509) were independently associated with DSS (p < 0.001), but histological subtype (HR: 1.423; 95 % CI: 0.798-2.538) was not a statistically significant factor (p = 0.232). Although pure SCC cases are diagnosed at advanced stages of the disease, UC and pure SCC cases have similar prognosis by stages. Lymph node involvement and stages are the most important prognostic factors after radical cystectomy.

Sneak Preview of April 25 Science at the Theater

ScienceCinema

Ho, Shirley

2017-12-12

Berkeley Lab astrophysicist Shirley Ho offers a sneak preview of the Science at the Theatre event at the Berkeley Repertory Theatre on April 25. Three Berkeley Lab cosmologists and Bay Area astronomer Andrew Fraiknoi will gather at the Berkeley Rep on Monday, April 25, from 7 to 9 p.m. to shed light on the mystery of the accelerating universe. Topics will include hunting down Type 1a supernovae, measuring the universe using baryon oscillation, and whether dark energy is the true driver of the universe. If you have questions for the scientists, post them below, send them to friendsofberkeleylab@lbl.gov, or catch us on facebook: http://www.facebook.com/video/video.php?v=10150215592292354&oid=593833429...Your question might be answered at the April 25 talk if there's time.

Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis

PubMed Central

Grewal, Suman; LaComb, Joseph F.; Park, Jiyhe; Channer, Breana; Rajapakse, Ramona; Bucobo, Juan Carlos; Buscaglia, Jonathan M.; Monzur, Farah; Chawla, Anupama; Yang, Jie; Robertson, Charlie E.; Frank, Daniel N.; Li, Ellen

2018-01-01

Background Studies of colonoscopic fecal microbiota transplant (FMT) in patients with recurrent CDI, indicate that this is a very effective treatment for preventing further relapses. In order to provide this service at Stony Brook University Hospital, we initiated an open-label prospective study of single colonoscopic FMT among patients with ≥ 2 recurrences of CDI, with the intention of monitoring microbial composition in the recipient before and after FMT, as compared with their respective donor. We also initiated a concurrent open label prospective trial of single colonoscopic FMT of patients with ulcerative colitis (UC) not responsive to therapy, after obtaining an IND permit (IND 15642). To characterize how FMT alters the fecal microbiota in patients with recurrent Clostridia difficile infections (CDI) and/or UC, we report the results of a pilot microbiome analysis of 11 recipients with a history of 2 or more recurrences of C. difficile infections without inflammatory bowel disease (CDI-only), 3 UC recipients with recurrent C. difficile infections (CDI + UC), and 5 UC recipients without a history of C. difficile infections (UC-only). Method V3V4 Illumina 16S ribosomal RNA (rRNA) gene sequencing was performed on the pre-FMT, 1-week post-FMT, and 3-months post-FMT recipient fecal samples along with those collected from the healthy donors. Fitted linear mixed models were used to examine the effects of Group (CDI-only, CDI + UC, UC-only), timing of FMT (Donor, pre-FMT, 1-week post-FMT, 3-months post-FMT) and first order Group*FMT interactions on the diversity and composition of fecal microbiota. Pairwise comparisons were then carried out on the recipient vs. donor and between the pre-FMT, 1-week post-FMT, and 3-months post-FMT recipient samples within each group. Results Significant effects of FMT on overall microbiota composition (e.g., beta diversity) were observed for the CDI-only and CDI + UC groups. Marked decreases in the relative abundances of the strictly anaerobic Bacteroidetes phylum, and two Firmicutes sub-phyla associated with butyrate production (Ruminococcaceae and Lachnospiraceae) were observed between the CDI-only and CDI + UC recipient groups. There were corresponding increases in the microaerophilic Proteobacteria phylum and the Firmicutes/Bacilli group in the CDI-only and CDI + UC recipient groups. At a more granular level, significant effects of FMT were observed for 81 genus-level operational taxonomic units (OTUs) in at least one of the three recipient groups (p<0.00016 with Bonferroni correction). Pairwise comparisons of the estimated pre-FMT recipient/donor relative abundance ratios identified 6 Gammaproteobacteria OTUs, including the Escherichia-Shigella genus, and 2 Fusobacteria OTUs with significantly increased relative abundance in the pre-FMT samples of all three recipient groups (FDR < 0.05), however the magnitude of the fold change was much larger in the CDI-only and CDI + UC recipients than in the UC-only recipients. Depletion of butyrate producing OTUs, such as Faecalibacterium, in the CDI-only and CDI + UC recipients, were restored after FMT. Conclusion The results from this pilot study suggest that the microbial imbalances in the CDI + UC recipients more closely resemble those of the CDI-only recipients than the UC-only recipients. PMID:29385143

Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis.

PubMed

Mintz, Michael; Khair, Shanawaj; Grewal, Suman; LaComb, Joseph F; Park, Jiyhe; Channer, Breana; Rajapakse, Ramona; Bucobo, Juan Carlos; Buscaglia, Jonathan M; Monzur, Farah; Chawla, Anupama; Yang, Jie; Robertson, Charlie E; Frank, Daniel N; Li, Ellen

2018-01-01

Studies of colonoscopic fecal microbiota transplant (FMT) in patients with recurrent CDI, indicate that this is a very effective treatment for preventing further relapses. In order to provide this service at Stony Brook University Hospital, we initiated an open-label prospective study of single colonoscopic FMT among patients with ≥ 2 recurrences of CDI, with the intention of monitoring microbial composition in the recipient before and after FMT, as compared with their respective donor. We also initiated a concurrent open label prospective trial of single colonoscopic FMT of patients with ulcerative colitis (UC) not responsive to therapy, after obtaining an IND permit (IND 15642). To characterize how FMT alters the fecal microbiota in patients with recurrent Clostridia difficile infections (CDI) and/or UC, we report the results of a pilot microbiome analysis of 11 recipients with a history of 2 or more recurrences of C. difficile infections without inflammatory bowel disease (CDI-only), 3 UC recipients with recurrent C. difficile infections (CDI + UC), and 5 UC recipients without a history of C. difficile infections (UC-only). V3V4 Illumina 16S ribosomal RNA (rRNA) gene sequencing was performed on the pre-FMT, 1-week post-FMT, and 3-months post-FMT recipient fecal samples along with those collected from the healthy donors. Fitted linear mixed models were used to examine the effects of Group (CDI-only, CDI + UC, UC-only), timing of FMT (Donor, pre-FMT, 1-week post-FMT, 3-months post-FMT) and first order Group*FMT interactions on the diversity and composition of fecal microbiota. Pairwise comparisons were then carried out on the recipient vs. donor and between the pre-FMT, 1-week post-FMT, and 3-months post-FMT recipient samples within each group. Significant effects of FMT on overall microbiota composition (e.g., beta diversity) were observed for the CDI-only and CDI + UC groups. Marked decreases in the relative abundances of the strictly anaerobic Bacteroidetes phylum, and two Firmicutes sub-phyla associated with butyrate production (Ruminococcaceae and Lachnospiraceae) were observed between the CDI-only and CDI + UC recipient groups. There were corresponding increases in the microaerophilic Proteobacteria phylum and the Firmicutes/Bacilli group in the CDI-only and CDI + UC recipient groups. At a more granular level, significant effects of FMT were observed for 81 genus-level operational taxonomic units (OTUs) in at least one of the three recipient groups (p<0.00016 with Bonferroni correction). Pairwise comparisons of the estimated pre-FMT recipient/donor relative abundance ratios identified 6 Gammaproteobacteria OTUs, including the Escherichia-Shigella genus, and 2 Fusobacteria OTUs with significantly increased relative abundance in the pre-FMT samples of all three recipient groups (FDR < 0.05), however the magnitude of the fold change was much larger in the CDI-only and CDI + UC recipients than in the UC-only recipients. Depletion of butyrate producing OTUs, such as Faecalibacterium, in the CDI-only and CDI + UC recipients, were restored after FMT. The results from this pilot study suggest that the microbial imbalances in the CDI + UC recipients more closely resemble those of the CDI-only recipients than the UC-only recipients.

Relationships among DNA hypomethylation, Cd, and Pb exposure and risk of cigarette smoking-related urothelial carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Chi-Jung

Cigarette smoking and environmental exposure to heavy metals are important global health issues, especially for urothelial carcinoma (UC). However, the effects of cadmium and lead exposure, as well as the levels of DNA hypomethylation, on UC risk are limited. We evaluated the possible exposure sources of Cd and Pb and the relationship among DNA hypomethylation, urinary Cd and Pb levels, and UC risk. We recruited 209 patients with UC and 417 control patients for a hospital-based case–control study between June 2011 and August 2014. We collected environmental exposure-related information with questionnaires. Blood and urine samples were analyzed to measure themore » Cd and Pb exposure and 5-methyl-2′-deoxycytidine levels as a proxy for DNA methylation. Multivariate logistic regression and 95% confidence intervals were applied to estimate the risk for UC. Study participants with high Cd and Pb exposure in blood or urine had significantly increased risk of UC, especially among the smokers. After adjusting for age and gender, the possible connections of individual cumulative cigarette smoking or herb medicine exposure with the increased levels of Cd and Pb were observed in the controls. Participants with 8.66%–12.39% of DNA hypomethylation had significantly increased risk of UC compared with those with ≥ 12.39% of DNA hypomethylation. Environmental factors including cigarette smoking and herb medicine may contribute to the internal dose of heavy metals levels. Repeat measurements of heavy metals with different study design, detailed dietary information, and types of herb medicine should be recommended for exploring UC carcinogenesis in future studies. - Highlights: • Smoking and herb medicine ingestion is associated with increased urinary Cd and Pb levels. • Urinary levels of Cd and Pb are associated with increased risk of UC. • UC carcinogenesis might have partially resulted from DNA hypomethylation.« less

Interns reflect: the effect of formative assessment with feedback during pre-internship.

PubMed

McKenzie, Susan; Burgess, Annette; Mellis, Craig

2017-01-01

It is widely known that the opportunity for medical students to be observed and to receive feedback on their procedural skills performance is variable in the senior years. To address this problem, we provided our Pre-Intern (PrInt) students with "one-to-one" formative feedback on their ability to perform urethral catheterization (U/C) and hypothesized that their future practice of U/C as interns would benefit. This study sought to evaluate the performance and practice of interns in U/C 4-5 months after having received feedback on their performance of U/C as PrInt students. Between 2013 and 2014, two cohorts of interns, (total n=66) who had received recent formative feedback on their U/C performance as PrInt students at Central Clinical School, were invited to complete an anonymous survey. The survey contained nine closed unvalidated questions and one open-ended question, designed to allow interns to report on their current practice of U/C. Forty-one out of 66 interns (62%) completed the survey. Thirty-five out of 41 respondents (85%) reported that the assessment with feedback during their PrInt term was beneficial to their practice. Thirty of 41 (73%) reported being confident to perform U/C independently. Eleven out of 41 respondents (27%) reported that they had received additional training at intern orientation. Nine of the 11 interns (82%) reported that they had a small, but a significant, increase in confidence to perform U/C when compared with the 30 of the 41 respondents (73%) who had not ( p =0.03). Our results substantiate our hypothesis that further education by assessment with feedback in U/C during PrInt was of benefit to interns' performance. Additional educational reinforcement in U/C during intern orientation further improved intern confidence. Our results indicate that extra pre- and post-graduation procedural skills training, with feedback, should be universal.

Interns reflect: the effect of formative assessment with feedback during pre-internship

PubMed Central

McKenzie, Susan; Burgess, Annette; Mellis, Craig

2017-01-01

Background It is widely known that the opportunity for medical students to be observed and to receive feedback on their procedural skills performance is variable in the senior years. To address this problem, we provided our Pre-Intern (PrInt) students with “one-to-one” formative feedback on their ability to perform urethral catheterization (U/C) and hypothesized that their future practice of U/C as interns would benefit. This study sought to evaluate the performance and practice of interns in U/C 4–5 months after having received feedback on their performance of U/C as PrInt students. Methods Between 2013 and 2014, two cohorts of interns, (total n=66) who had received recent formative feedback on their U/C performance as PrInt students at Central Clinical School, were invited to complete an anonymous survey. The survey contained nine closed unvalidated questions and one open-ended question, designed to allow interns to report on their current practice of U/C. Results Forty-one out of 66 interns (62%) completed the survey. Thirty-five out of 41 respondents (85%) reported that the assessment with feedback during their PrInt term was beneficial to their practice. Thirty of 41 (73%) reported being confident to perform U/C independently. Eleven out of 41 respondents (27%) reported that they had received additional training at intern orientation. Nine of the 11 interns (82%) reported that they had a small, but a significant, increase in confidence to perform U/C when compared with the 30 of the 41 respondents (73%) who had not (p=0.03). Conclusion Our results substantiate our hypothesis that further education by assessment with feedback in U/C during PrInt was of benefit to interns’ performance. Additional educational reinforcement in U/C during intern orientation further improved intern confidence. Our results indicate that extra pre- and post-graduation procedural skills training, with feedback, should be universal. PMID:28138270

Extracellular Vesicles Released from Human Umbilical Cord-Derived Mesenchymal Stromal Cells Prevent Life-Threatening Acute Graft-Versus-Host Disease in a Mouse Model of Allogeneic Hematopoietic Stem Cell Transplantation.

PubMed

Wang, Li; Gu, Zhenyang; Zhao, Xiaoli; Yang, Nan; Wang, Feiyan; Deng, Ailing; Zhao, Shasha; Luo, Lan; Wei, Huaping; Guan, Lixun; Gao, Zhe; Li, Yonghui; Wang, Lili; Liu, Daihong; Gao, Chunji

2016-12-15

Mesenchymal stromal cells (MSCs) are attractive agents for the prophylaxis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, safety concerns remain about their clinical application. In this study, we explored whether extracellular vesicles released from human umbilical cord-derived MSCs (hUC-MSC-EVs) could prevent aGVHD in a mouse model of allo-HSCT. hUC-MSC-EVs were intravenously administered to recipient mice on days 0 and 7 after allo-HSCT, and the prophylactic effects of hUC-MSC-EVs were assessed by observing the in vivo manifestations of aGVHD, histologic changes in target organs, and recipient mouse survival. We evaluated the effects of hUC-MSC-EVs on immune cells and inflammatory cytokines by flow cytometry and ProcartaPlex™ Multiplex Immunoassays, respectively. The in vitro effects of hUC-MSC-EVs were determined by mitogen-induced proliferation assays. hUC-MSC-EVs alleviated the in vivo manifestations of aGVHD and the associated histologic changes and significantly reduced the mortality of the recipient mice. Recipients treated with hUC-MSC-EVs had significantly lower frequencies and absolute numbers of CD3 + CD8 + T cells; reduced serum levels of IL-2, TNF-α, and IFN-γ; a higher ratio of CD3 + CD4 + and CD3 + CD8 + T cells; and higher serum levels of IL-10. An in vitro experiment demonstrated that hUC-MSC-EVs inhibited the mitogen-induced proliferation of splenocytes in a dose-dependent manner, and the cytokine changes were similar to those observed in vivo. This study indicated that hUC-MSC-EVs can prevent life-threatening aGVHD by modulating immune responses. These data provide the first evidence that hUC-MSC-EVs represent an ideal alternative in the prophylaxis of aGVHD after allo-HSCT.

Direct comparison of two different mesalamine formulations for the induction of remission in patients with ulcerative colitis: A double-blind, randomized study

PubMed Central

Ito, Hiroaki; Iida, Mitsuo; Matsumoto, Takayuki; Suzuki, Yasuo; Sasaki, Hidetaka; Yoshida, Toyomitsu; Takano, Yuichi; Hibi, Toshifumi

2010-01-01

Background: Mesalamine is the first-line drug for the treatment of ulcerative colitis (UC). We directly compared the efficacy and safety of two mesalamine formulations for the induction of remission in patients with UC. Methods: In a multicenter, double-blind, randomized study, 229 patients with mild-to-moderate active UC were assigned to 4 groups: 66 and 65 received a pH-dependent release formulation of 2.4 g/day (pH-2.4 g) or 3.6 g/day (pH-3.6 g), respectively; 65 received a time-dependent release formulation of 2.25 g/day (Time-2.25 g), and 33 received placebo (Placebo). The drugs were administered three times daily for eight weeks. The primary endpoint was a decrease in the UC disease activity index (UC-DAI). Results: In the full analysis set (n = 225) the decrease in UC-DAI in each group was 1.5 in pH-2.4 g, 2.9 in pH-3.6 g, 1.3 in Time-2.25 g and 0.3 in Placebo, respectively. These results demonstrate the superiority of pH-3.6 g over Time-2.25 g (P = 0.003) and the noninferiority of pH-2.4 g to Time-2.25 g. Among the patients with proctitis-type UC, a significant decrease in UC-DAI was observed in pH-2.4 g and pH-3.6 g as compared to Placebo, but not in Time-2.25 g. No differences were observed in the safety profiles. Conclusions: Higher dose of the pH-dependent release formulation was more effective for induction of remission in patients with mild-to-moderate active UC. Additionally, the pH-dependent release formulation was preferable to the time-dependent release formulation for patients with proctitis-type UC (UMIN Clinical Trials Registry, no. C000000288). (Inflamm Bowel Dis 2010) PMID:20049950

The risk of bladder cancer in patients with urinary calculi: a meta-analysis.

PubMed

Yu, Zhang; Yue, Wu; Jiuzhi, Li; Youtao, Jiang; Guofei, Zhang; Wenbin, Guo

2018-01-05

The objective of this meta-analysis was to evaluate the association between a history of urinary calculi (UC) and the risk of bladder cancer (BC). A literature search was performed from inception until July 2017. Studies that reported odds ratios (OR), relative risks or hazard ratios comparing the risk of BC in patients with the history of UC vs those without the history of UC were included. Pooled odds ratios and 95% confidence interval (CI) were calculated using a random-effect or fixed-effect method. Thirteen studies were included in our analysis to assess the association between a history of UC and risk of BC. The pooled OR of BC in patients with UC was 1.87 (95% CI, 1.45-2.41). Bladder calculi [OR, 2.17 (95% CI, 1.52-3.08)] had a higher risk of BC than kidney calculi [OR, 1.39 (95% CI, 1.06-1.82)]. The subjects had a history of UC that was associated with increased BC risk both in males [OR, 2.04 (95% CI, 1.41-2.96)] and in females [OR, 2.99 (95% CI, 2.37-3.76)]. The subgroup analysis demonstrated that UC increasing risk of BC both in case-control studies [OR, 1.75 (95% CI, 1.25-2.45)] and cohort studies [OR, 2.27 (95% CI, 1.55-3.32)]. The pooled OR of BC risk in patients with UC were 1.60 (95% CI, 1.15-2.24) in America, 1.36 (95% CI, 1.14-1.64) in Europe and 3.05 (95% CI, 2.21-4.21) in Asia, respectively. Our study demonstrates a significant increased risk of BC in patients with prior UC. This finding suggests that a history of UC is associated with BC and may impact clinical management and cancer surveillance. Further studies still needed to confirm the findings.

Gastroenterologists' Perceptions Regarding Ulcerative Colitis and Its Management: Results from a Large-Scale Survey.

PubMed

Lasch, Karen; Liu, Stephen; Ursos, Lyann; Mody, Reema; King-Concialdi, Kristen; DiBonaventura, Marco; Leberman, Julie; Dubinsky, Marla

2016-10-01

Misperceptions about ulcerative colitis (UC) may influence management strategies and limit opportunities for improving patient outcomes. This study assessed physicians' perceptions of UC, concepts of disease severity and remission, and treatment goals. Gastroenterologists who typically treated ≥10 adults with UC per month were recruited for a large-scale, web-based survey. Participants were asked about their perceptions of UC (often vs. Crohn's disease [CD]), treatment goals, and medication use. Response data were evaluated via descriptive statistics and univariate and multivariable analyses. Gastroenterologists (N = 500) with a mean of 16.5 years (standard deviation, 8.7 years) in practice participated. In comparison to CD, survey respondents perceived UC as being easier to diagnose, having better treatment outcomes, and being associated with later prescribing of biologics. Treatment goals commonly considered to have the greatest importance included quality of life improvement (31.2% of respondents), maintenance of clinical remission (17.4%), and mucosal healing (17.4%). When respondents evaluated the performance of medication classes in achieving these goals, biologics were rated significantly higher than all other classes (P < 0.05). However, the most common drivers for the initiation of biologic therapy were the development of steroid refractoriness (66.8%) and steroid dependency (65.8%). Medication class use by UC severity was generally consistent with the traditional step-up approach to UC therapy, with biologics being used most commonly for severe UC. These results suggest a possible disparity between treatment goals and therapeutic management in UC. An increased awareness of general UC perceptions is an important step toward a better overall understanding of the disease and, ultimately, toward improved management aligned with treatment goals. This study was sponsored by the American Gastroenterological Association (AGA), and the design and conduct of the study as well as article processing charges and the open access fee for this publication were funded by Takeda Pharmaceuticals International, Inc. (TPI).

Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to Differentiate Crohn's Disease from Ulcerative Colitis.

PubMed

Mortensen, Joachim Høg; Godskesen, Line Elbjerg; Jensen, Michael Dam; Van Haaften, Wouter Tobias; Klinge, Lone Gabriels; Olinga, Peter; Dijkstra, Gerard; Kjeldsen, Jens; Karsdal, Morten Asser; Bay-Jensen, Anne-Christine; Krag, Aleksander

2015-10-01

A hallmark of inflammatory bowel disease [IBD] is chronic inflammation, which leads to excessive extracellular matrix [ECM] remodelling and release of specific protein fragments, called neoepitopes. We speculated that the biomarker profile panel for ulcerative colitis [UC] and Crohn's disease [CD] represent a heterogeneous expression pattern, and may be applied as a tool to aid in the differentiation between UC and CD. Serum biomarkers of degraded collagens I, III-IV [C1M, C3M, and C4M], collagen type 1 and IV formation [P1NP, P4NP], and citrullinated and MMP-degraded vimentin [VICM] were studied with a competitive ELISA assay system in a cohort including 164 subjects [CD n = 72, UC n = 60, and non-IBD controls n = 32] and a validation cohort of 61 subjects [CD n = 46, and UC n = 15]. Receiver operating characteristic curve analysis and logistic regression modelling were carried out to evaluate the discriminative power of the biomarkers. All biomarkers were corrected for confounding factors. VICM and C3M demonstrated the highest diagnostic power, alone, to differentiate CD from UC with an area under the curve [AUC] of 0.77 and 0.69, respectively. Furthermore, the biomarkers C1M [AUC = 0.81], C3M [AUC = 0.83], VICM [AUC = 0.83], and P1NP [AUC = 0.77] were best to differentiate UC from non-IBD. The best combinations of biomarkers to differentiate CD from UC and UC from non-IBD were VICM, C3M, C4M [AUC = 0.90] and VICM, C3M [AUC = 0.98] respectively. Specific extracellular matrix degradation markers are elevated in IBD and can discriminate CD from UC and UC from non-IBD controls with a high diagnostic accuracy. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Beverage consumption and risk of ulcerative colitis: Systematic review and meta-analysis of epidemiological studies.

PubMed

Nie, Jia-Yan; Zhao, Qiu

2017-12-01

Epidemiological studies have provided controversial evidence between beverage consumption and the risk of ulcerative colitis (UC). This study aimed to determine the role of beverage consumption in the development of UC. A systematic search was conducted in public databases to identify all relevant studies, and study-specific relative risks (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model. Sixteen studies were identified with a total of 3689 cases and 335,339 controls. Alcohol consumption showed no significant association with UC risk (RR for the highest vs the lowest consumption level: 0.95, 95% CI: 0.65-1.39). Coffee consumption tended to be inversely associated with UC risk (RR: 0.58, 95% CI: 0.33-1.05), but it was not significant and confounded by smoking adjustment. Soft drinks consumption was associated with UC risk (RR: 1.69, 95% CI: 1.24-2.30), and tea consumption was inversely associated with UC risk (RR: 0.69, 95% CI: 0.58-0.83). In conclusion, high consumption of soft drinks might increase the risk of UC, while tea consumption might decrease the risk.

Experimental study of UC polycrystals in the prospect of improving the as-fabricated sample purity

NASA Astrophysics Data System (ADS)

Raveu, Gaëlle; Martin, Guillaume; Fiquet, Olivier; Garcia, Philippe; Carlot, Gaëlle; Palancher, Hervé; Bonnin, Anne; Khodja, Hicham; Raepsaet, Caroline; Sauvage, Thierry; Barthe, Marie-France

2014-12-01

Uranium and plutonium carbides are candidate fuels for Generation IV nuclear reactors. This study is focused on the characterization of uranium monocarbide samples. The successive fabrication steps were carried out under atmospheres containing low oxygen and moisture concentrations (typically less than 100 ppm) but sample transfers occurred in air. Six samples were sliced from four pellets elaborated by carbothermic reaction under vacuum. Little presence of UC2 is expected in these samples. The α-UC2 phase was indeed detected within one of these UC samples during an XRD experiment performed with synchrotron radiation. Moreover, oxygen content at the surface of these samples was depth profiled using a recently developed nuclear reaction analysis method. Large oxygen concentrations were measured in the first micron below the sample surface and particularly in the first 100-150 nm. UC2 inclusions were found to be more oxidized than the surrounding matrix. This work points out to the fact that more care must be given at each step of UC fabrication since the material readily reacts with oxygen and moisture. A new glovebox facility using a highly purified atmosphere is currently being built in order to obtain single phase UC samples of better purity.

The Role of Triplet Exciton Diffusion in Light-Upconverting Polymer Glasses.

PubMed

Raišys, Steponas; Kazlauskas, Karolis; Juršėnas, Saulius; Simon, Yoan C

2016-06-22

Light upconversion (UC) via triplet-triplet annihilation (TTA) by using noncoherent photoexcitation at subsolar irradiance power densities is extremely attractive, particularly for enhanced solar energy harvesting. Unfortunately, practical TTA-UC application is hampered by low UC efficiency of upconverting polymer glasses, which is commonly attributed to poor exciton diffusion of the triplet excitons across emitter molecules. The present study addresses this issue by systematically evaluating triplet exciton diffusion coefficients and diffusion lengths (LD) in a UC model system based on platinum-octaethylporphyrin-sensitized poly(methyl methacrylate)/diphenylanthracene (emitter) films as a function of emitter concentration (15-40 wt %). For this evaluation time-resolved photoluminescence bulk-quenching technique followed by Stern-Volmer-type quenching analysis of experimental data was employed. The key finding is that although increasing emitter concentration in the disordered PMMA/DPA/PtOEP films improves triplet exciton diffusion, and thus LD, this does not result in enhanced UC quantum yield. Conversely, improved LD accompanied by the accelerated decay of UC intensity on millisecond time scale degrades TTA-UC performance at high emitter loadings (>25 wt %) and suggests that diffusion-enhanced nonradiative decay of triplet excitons is the major limiting factor.

Space Radiation and Cataracts (LBNL Summer Lecture Series)

ScienceCinema

Blakely, Eleanor [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division

2018-01-23

Summer Lecture Series 2009: Eleanor Blakely, radiation biologist of the Life Sciences Division at Lawrence Berkeley National Laboratory, has been a scientist at Berkeley Lab since 1975. She is studying the effect of radiation on cataracts which concerns not only cancer patients, but also astronauts. As astronauts spend increasingly longer time in space, the effects of cosmic radiation exposure will become an increasingly important health issue- yet there is little human data on these effects. Blakely reviews this emerging field and the contributions made at Berkeley Lab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Todd DeSantis

Scientists at Berkeley Lab and the University of California, Merced are using an innovative DNA array developed at Berkeley Lab to catalog the microbes that live among coral in the tropical waters off the coast of Puerto Rico.

Predictors of Outcome in Ulcerative Colitis.

PubMed

Waterman, Matti; Knight, Jo; Dinani, Amreen; Xu, Wei; Stempak, Joanne M; Croitoru, Kenneth; Nguyen, Geoffrey C; Cohen, Zane; McLeod, Robin S; Greenberg, Gordon R; Steinhart, A Hillary; Silverberg, Mark S

2015-09-01

Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors of poor disease course. The aim of this study was to identify clinical and genetic markers that can predict prognosis. Medical records of patients with UC with ≥5 years of follow-up and available DNA and serum were retrospectively assessed. Immunochip was used to genotype loci associated with immune mediated inflammatory disorders (IMIDs), inflammatory bowel diseases, and other single nucleotide polypmorphisms previously associated with disease severity. Serum levels of pANCA, ASCA, CBir1, and OmpC were also evaluated. Requirement for colectomy, medication, and hospitalization were used to group patients into 3 prognostic groups. Six hundred one patients with UC were classified as mild (n = 78), moderate (n = 273), or severe disease (n = 250). Proximal disease location frequencies at diagnosis were 13%, 21%, and 30% for mild, moderate, and severe UC, respectively (P = 0.001). Disease severity was associated with greater proximal extension rates on follow-up (P < 0.0001) and with shorter time to extension (P = 0.03) and to prednisone initiation (P = 0.0004). When comparing severe UC with mild and moderate UC together, diagnosis age >40 and proximal disease location were associated with severe UC (odds ratios = 1.94 and 2.12, respectively). None of the single nucleotide polypmorphisms or serum markers tested was associated with severe UC, proximal disease extension or colectomy. Older age and proximal disease location at diagnosis, but not genetic and serum markers, were associated with a more severe course. Further work is required to identify biomarkers that will predict outcomes in UC.

Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Function of Allogeneic Activated Vγ9Vδ2 T Lymphocytes In Vitro

PubMed Central

Liu, Xiaohuan; Feng, Ting; Gong, Tianxiang; Shen, Chongyang; Zhu, Tingting; Wu, Qihong; Li, Qiang; Li, Hong

2015-01-01

Background. Human umbilical cord mesenchymal stem cells (UC-MSCs) can regulate the function of immune cells. However, whether and how UC-MSCs can modulate the function of Vγ9Vδ2 T cells has not been fully understood. Methods. The PBMCs or Vγ9Vδ2 T cells were activated and expanded with pamidronate (PAM) and interleukin-2 (IL-2) with or without the presence UC-MSCs. The effects of UC-MSCs on the proliferation, cytokine expression, and cytotoxicity of Vγ9Vδ2 T cells were determined by flow cytometry. The effects of UC-MSCs on Fas-L, TRAIL-expressing Vγ9Vδ2 T cells, and Vγ9Vδ2 T cell apoptosis were determined by flow cytometry. Results. UC-MSCs inhibited Vγ9Vδ2 T cell proliferation in a dose-dependent but cell-contact independent manner. Coculture with UC-MSCs reduced the frequency of IFNγ+ but increased granzyme B+ Vγ9Vδ2 T cells. UC-MSCs inhibited the cytotoxicity of Vγ9Vδ2 T cells against influenza virus H1N1 infected A549 cells and also reduced the frequency of Fas-L+, TRAIL+ Vγ9Vδ2 T cells but failed to modulate the apoptosis of Vγ9Vδ2 T cells. Conclusions. These results indicated that UC-MSCs efficiently suppressed the proliferation and cytotoxicity of Vγ9Vδ2 T cells and modulated their cytokine production. Fas-L and TRAIL were involved in the regulation. Cell contact and apoptosis of Vγ9Vδ2 T cells were not necessary for the inhibition. PMID:25984529

Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α

PubMed Central

Liu, Chang; Tang, Xiaojun; Feng, Ruihai; Yao, Genhong; Chen, Weiwei; Li, Wenchao; Liang, Jun; Feng, Xuebing

2018-01-01

Objective To investigate the effects of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on joint damage and osteoporosis in collagen-induced arthritis (CIA) mice and to explore the mechanisms by which UC-MSCs modulate the osteogenic differentiation. Methods CIA mice were divided into the following treated groups: UC-MSC transplantation group, antitumor necrosis factor- (TNF-) α group, and zoledronic acid (ZA) group. Microcomputed tomography (micro-CT) was used to analyze the bone morphology parameters. Osteogenic differentiation of treated CIA mice was determined. Bone marrow mesenchymal stem cells (BM-MSCs) from CIA mice were treated with TNF-α in vitro to explore their effects on osteogenesis. Results The arthritis score was significantly reduced in the UC-MSC transplantation and anti-TNF-α-treated CIA groups, compared with control mice (P < 0.001). Micro-CT showed that CIA mice developed osteoporosis at 12 weeks after immunization. The bone morphology parameters were partially improved in UC-MSC-treated CIA mice. Impaired osteogenic differentiation functions were indicated by decreased ALP activity (P < 0.001) and reduced mRNA and protein levels of osteogenic marker genes (P < 0.05) in CIA mice compared with DBA/1 mice. UC-MSC treatment significantly upregulated the impaired osteogenic differentiation ability in CIA mice. Meanwhile, the serum TNF-α level was decreased significantly in the UC-MSC group. The osteogenesis was reduced with the addition of TNF-α in vitro. Conclusion This study demonstrated that UC-MSC transplantation not only significantly improved the joint damage but also played a beneficial role in osteoporosis in CIA mice. Mechanistically, the improved osteogenic differentiation of CIA under UC-MSC treatment may be achieved by inhibition of TNF-α. PMID:29853911

Clinical epidemiology of ulcerative colitis in Arabs based on the Montréal classification.

PubMed

Alharbi, Othman R; Azzam, Nahla A; Almalki, Ahmed S; Almadi, Majid A; Alswat, Khalid A; Sadaf, Nazia; Aljebreen, Abdulrahman M

2014-12-14

To determine the clinical, epidemiological and phenotypic characteristics of ulcerative colitis (UC) in Saudi Arabia by studying the largest cohort of Arab UC patients. Data from UC patients attending gastroenterology clinics in four tertiary care centers in three cities between September 2009 and September 2013 were entered into a validated web-based registry, inflammatory bowel disease information system (IBDIS). The IBDIS database covers numerous aspects of inflammatory bowel disease. Patient characteristics, disease phenotype and behavior, age at diagnosis, course of the disease, and extraintestinal manifestations were recorded. Among 394 UC patients, males comprised 51.0% and females 49.0%. According to the Montréal classification of age, the major chunk of our patients belonged to the A2 category for age of diagnosis at 17-40 years (68.4%), while 24.2% belonged to the A3 category for age of diagnosis at > 40 years. According to the same classification, a majority of patients had extensive UC (42.7%), 35.3% had left-sided colitis and 29.2% had only proctitis. Moreover, 51.3% were in remission, 16.6% had mild UC, 23.4% had moderate UC and 8.6% had severe UC. Frequent relapse occurred in 17.4% patients, infrequent relapse in 77% and 4.8% had chronic disease. A majority (85.2%) of patients was steroid responsive. With regard to extraintestinal manifestations, arthritis was present in 16.4%, osteopenia in 31.4%, osteoporosis in 17.1% and cutaneous involvement in 7.0%. The majority of UC cases were young people (17-40 years), with a male preponderance. While the disease course was found to be similar to that reported in Western countries, more similarities were found with Asian countries with regards to the extent of the disease and response to steroid therapy.

Reducing unnecessary urinary catheter use and other strategies to prevent catheter-associated urinary tract infection: an integrative review

PubMed Central

Meddings, Jennifer; Rogers, Mary A M; Krein, Sarah L; Fakih, Mohamad G; Olmsted, Russell N; Saint, Sanjay

2014-01-01

Background Catheter-associated urinary tract infections (CAUTI) are costly, common and often preventable by reducing unnecessary urinary catheter (UC) use. Methods To summarise interventions to reduce UC use and CAUTIs, we updated a prior systematic review (through October 2012), and a meta-analysis regarding interventions prompting UC removal by reminders or stop orders. A narrative review summarises other CAUTI prevention strategies including aseptic insertion, catheter maintenance, antimicrobial UCs, and bladder bundle implementation. Results 30 studies were identified and summarised with interventions to prompt removal of UCs, with potential for inclusion in the meta-analyses. By meta-analysis (11 studies), the rate of CAUTI (episodes per 1000 catheter-days) was reduced by 53% (rate ratio 0.47; 95% CI 0.30 to 0.64, p<0.001) using a reminder or stop order, with five studies also including interventions to decrease initial UC placement. The pooled (nine studies) standardised mean difference (SMD) in catheterisation duration (days) was −1.06 overall (p=0.065) including a statistically significant decrease in stop-order studies (SMD −0.37; p<0.001) but not in reminder studies (SMD, −1.54; p=0.071). No significant harm from catheter removal strategies is supported. Limited research is available regarding the impact of UC insertion and maintenance technique. A recent randomised controlled trial indicates antimicrobial catheters provide no significant benefit in preventing symptomatic CAUTIs. Conclusions UC reminders and stop orders appear to reduce CAUTI rates and should be used to improve patient safety. Several evidence-based guidelines have evaluated CAUTI preventive strategies as well as emerging evidence regarding intervention bundles. Implementation strategies are important because reducing UC use involves changing well-established habits. PMID:24077850