Radiochemistry Research and Training, UC Davis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutcliffe, Julie

2012-08-01

The report contains a summary of the accomplishments made during the R2@UCDavis proposal. In brief we proposed to develop new and highly innovative radiotracer methods and to enhance training opportunities to ensure the future availability of human resources for highly specialized fields of radiotracer development chemistry and clinical nuclear medicine research and allied disciplines. The overall scientific objectives of this proposal were to utilize “click” chemistry to facilitate fast and site-specific radiolabeling. Progress was made on all initial goals presented. This funding has to date resulted in publications in high impact journals such as Acta Biomaterialia, Molecular Imaging and Biology,more » Nuclear Medicine and Biology and most recently Environmental Science and technology, and it is anticipated that through the collaborations established during the time course of this funding that future research will be published in clinically relevant journals such as Science Translational Medicine and the Journal of Nuclear Medicine. Trainees involved in this proposal have gone on to further their careers in both academia, industry and the private sector. The collaborative forums established during the time course of this funding will ensure the future availability of human resources for highly specialized fields of radiotracer development chemistry and clinical nuclear medicine research and allied disciplines.« less

Development of a UC781 releasing polyethylene vinyl acetate vaginal ring.

PubMed

McConville, Christopher; Major, Ian; Friend, David R; Clark, Meredith R; Malcolm, R Karl

2012-12-01

UC781 is potent, hydrophobic, non-nucleotide reverse transcriptase inhibitor (NNRTI) against the human immunodeficiency virus (HIV). UC781 is currently being investigated for use as a potential HIV microbicide. A study in rhesus macaques demonstrated that a 100-mg UC781-loaded silicone elastomer vaginal ring released limited amounts of UC781 into the vaginal fluid and tissue after 28 days. The reason for this was due to the hydrophobic nature and limited aqueous solubility of UC781. This study describes the manufacture of UC781-loaded polyethylene vinyl acetate (PEVA) vaginal rings, which have an improved in vitro release rate of UC781 when compared to UC781-loaded silicone elastomer vaginal rings. The study demonstrates that the UC781 in the PEVA rings is mostly in its amorphous form due to the rings being manufactured above UC781's melting point. Furthermore, the rings do not show any signs of UC781 degradation, such as the presence of UC22.

Isotopic Survey of Lake Davis and the Local Groundwater

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ridley, M N; Moran, J E; Singleton, M J

2007-08-21

In September 2007, California Fish and Game (CAFG) plans to eradicate the northern pike from Lake Davis. As a result of the eradication treatment, local residents have concerns that the treatment might impact the local groundwater quality. To address the concerns of the residents, Lawrence Livermore National Laboratory (LLNL) recommended measuring the naturally occurring stable oxygen isotopes in local groundwater wells, Lake Davis, and the Lake Davis tributaries. The purpose of these measurements is to determine if the source of the local groundwater is either rain/snowmelt, Lake Davis/Big Grizzly Creek water or a mixture of Lake Davis/Big Grizzly Creek andmore » rain/snowmelt. As a result of natural evaporation, Lake Davis and the water flowing into Big Grizzly Creek are naturally enriched in {sup 18}oxygen ({sup 18}O), and if a source of a well's water is Lake Davis or Big Grizzly Creek, the well water will contain a much higher concentration of {sup 18}O. This survey will allow for the identification of groundwater wells whose water source is Lake Davis or Big Grizzly Creek. The results of this survey will be useful in the development of a water-quality monitoring program for the upcoming Lake Davis treatment. LLNL analyzed 167 groundwater wells (Table 1), 12 monthly samples from Lake Davis (Table 2), 3 samples from Lake Davis tributaries (Table 2), and 8 Big Grizzly Creek samples (Table 2). Of the 167 groundwater wells sampled and analyzed, only 2 wells contained a significant component of evaporated water, with an isotope composition similar to Lake Davis water. The other 163 groundwater wells have isotope compositions which indicate that their water source is rain/snowmelt.« less

Environmental assessment: Davis Canyon site, Utah

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

1986-05-01

In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOEmore » prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has fond that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization. 181 figs., 175 tabs.« less

Environmental assessment: Davis Canyon site, Utah

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

1986-05-01

In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high- level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, themore » DOE prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has found that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of the five sites suitable for characterization.« less

Environmental assessment: Davis Canyon site, Utah

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

1986-05-01

In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah as one of the nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. These evaluations were reported in draft environmental assessments (EAs), which were issued for public review and comment. After considering the comments received on the draft EAs, the DOEmore » prepared the final EA. The Davis Canyon site is in the Paradox Basin, which is one of five distinct geohydrologic settings considering for the first repository. This setting contains one other potentially acceptable site -- the Lavender Canyon site. Although the Lavender Canyon site is suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. On the basis of the evaluations reported in this EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. Furthermore, the DOE has found that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is nominating the Davis Canyon site as one of five sites suitable for characterization.« less

Mass Spectrometry Data Set for Renal Cell Carcinoma and Polycystic Kidney Disease Cell Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, B. J.

This data set will be evaluated by collaborators at UC Davis for possible inclusion in a research paper for publication in a scientific journal and to assist in the design of additional experiments. Researchers from UC Davis and LLNL will contribute to the manuscript.

Epidemiology of tennis injuries: An eight-year review of Davis Cup retirements.

PubMed

Maquirriain, Javier; Baglione, Roberto

2016-01-01

Tennis practice, especially at elite levels, may place players at risk for debilitating musculoskeletal injuries. The aim of this study was to analyse the epidemiological pattern of retirements due to medical conditions sustained by tennis players during Davis Cup matches in the 2006-2013 period. All uncompleted matches due to a medical condition (injuries and illnesses) occurred in the above-mentioned competition were collected from the official source, registered and analysed according to published guidelines. The overall incidence of match retirements was 1.66% (12/719). The injury rate was 6.05/1000 playing hours; and 6.64/1000 match exposures. Musculotendinous lesions were the most common type of injury (66.66%). The incidence of lower-limb injuries was higher than upper-limb and trunk lesions. The incidence of retired matches due to medical conditions was higher in hard courts than in clay courts (2.97% and 0.90%, respectively; p = 0.04), while the median value of inactivity of injuries was 32.0 days (range 3-297). In conclusion, the incidence of retirements due to medical conditions in Davis Cup matches was low supporting the assumption that elite tennis is a low-risk sport activity. Findings provided scientific evidences of injury patterns among male professional tennis players and may contribute to conduct better injury prevention strategies.

TECHcitement: Advances in Technological Education, 2003

ERIC Educational Resources Information Center

American Association of Community Colleges (NJ1), 2003

2003-01-01

This edition of "TECHcitement" contains the following articles: (1) ATE Changes the Way People Learn and Work; (2) UC-Davis' Bioinformatics for Community College Faculty Moves Students to High Tech's Leading Edge; (3) CCSF Students Checking Medical Research Tests; (4) ATE Bridging Gap between Researchers and Practitioners; (5) MATE Center; (6) ATE…

76 FR 19952 - Davy Crockett National Forest Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

... DEPARTMENT OF AGRICULTURE Davy Crockett National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Davy Crockett National Forest Resource Advisory Committee... 1972 (FACA), the U.S. Department of Agriculture, Forest Service, Davy Crockett National Forest Resource...

Obituary: Leverett Davis, Jr., 1914-2003

NASA Astrophysics Data System (ADS)

Jokipii, Jack Randolph

2004-12-01

Professor Leverett Davis Jr., Professor of theoretical physics at the California Institute of Technology, died on June 15, 2003 after a long illness. He was 89 years old. He contributed many important ideas and concepts to theoretical astrophysics and was a pioneer in the in situ scientific exploration of space using observations from spacecraft. Davis was born in Elgin, Illinois on March 3, 1914, the eldest of four children of Louis Leverett Davis and Susan Gulick Davis. His parents moved several times as he grew up because his father, a mining engineer, became involved in different mining operations in the American West. Leverett married Victoria Stocker in June 1943. They had two children who died in childhood and subsequently adopted a son, Jeffrey. His wife and son survive him. Davis's early education was rather fractured and uneven because of the many family moves, with periods of home schooling alternating with regular school. His high school education was, on the other hand, reasonably normal. It was while in high school that he decided that he wanted to do physics or mathematics. He went on to earn his Bachelor of Science degree at Oregon State College in 1936, after which he started graduate studies at the California Institute of Technology, to pursue a graduate degree in physics. His advisor was William V. Houston and Davis received his PhD in 1941 for a thesis on electrical properties in nerves. He briefly entertained the idea of changing to work in biophysics. During World War II, Davis became an integral member of the Caltech project for rockets, which developed a number of different types of rockets used in the war. As a result of this war work, Davis wrote a book on Exterior Ballistics, published by Van Nostrand in 1958. He joined the faculty at the California Institute of Technology in 1946, after several years on campus as an instructor. In all, he taught there for nearly four decades before retiring as Professor of Theoretical Physics in 1981

Light atom quantum oscillations in UC and US

DOE PAGES

Yiu, Yuen; Aczel, Adam A.; Granroth, Garrett E.; ...

2016-01-19

High energy vibrational scattering in the binary systems UC and US is measured using time-of-flight inelastic neutron scattering. A clear set of well-defined peaks equally separated in energy is observed in UC, corresponding to harmonic oscillations of the light C atoms in a cage of heavy U atoms. The scattering is much weaker in US and only a few oscillator peaks are visible. We show how the difference between the materials can be understood by considering the neutron scattering lengths and masses of the lighter atoms. Monte Carlo ray tracing is used to simulate the scattering, with near quantitative agreementmore » with the data in UC, and some differences with US. The possibility of observing anharmonicity and anisotropy in the potentials of the light atoms is investigated in UC. Lastly, the observed data is well accounted for by considering each light atom as a single atom isotropic quantum harmonic oscillator.« less

Disposition and metabolism of 2,3-( UC)dichloropropene in rats after inhalation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bond, J.A.; Medinsky, M.A.; Dutcher, J.S.

1985-01-01

2,3-Dichloropropene (2,3-DCP) is a constituent of some commercially available preplant soil fumigants for the control of plant parasitic nematodes. The purpose of this investigation was to determine the disposition and metabolism of 2,3-( UC)DCP in rats after inhalation. Male Fischer-344 rats were exposed nose-only to a vapor concentration of 250 nmol 2,3-( UC)DCP/liter air (7.5 ppm; 25C, 620 Torr) for 6 hr. Blood samples were taken during exposure, and urine, feces, expired air, and tissues were collected for up to 65 hr after exposure. Urinary excretion was the major route of elimination of UC (55% of estimated absorbed 2,3-DCP). Half-timemore » for elimination of UC in urine was 9.8 +/- 0.05 hr (anti x +/- SE). Half-time for elimination of UC feces (17% of absorbed 2,3-DCP) was 12.9 +/- 0.14 hr (anti x +/- SE). Approximately 1 and 3% of the estimated absorbed 2,3-( UC)DCP were exhaled as either 2,3-( UC)DCP or UCO2, respectively. Concentrations of UC in blood increased during 240 min of exposure, after which no further increases in blood concentration of UC were seen. UC was widely distributed in tissues analyzed after a 6-hr exposure of rats to 2,3-( UC)DCP. Urinary bladder (150 nmol/g), nasal turbinates (125 nmol/g), kidneys (84 nmol/g), small intestine (61 nmol/g), and liver (35 nmol/g) were tissues with the highest concentrations of UC immediately after exposure. Over 90% of the UC in tissues analyzed was 2,3-DCP metabolites. Half-times for elimination of UC from tissues examined ranged from 3 to 11 hr. The data from this study indicate that after inhalation 2,3-DCP is metabolized in tissues and readily excreted. 21 references. 2 figures, 4 tables.« less

9th Annual UC Systemwide Bioengineering Symposium

DTIC Science & Technology

2008-08-01

Morikis UCR CHUNSHENG WANG University of California San Francisco Christopher Druzgalski PAHCE Jeffrey Chen UC Riverside BRITE Adriana Aguirre UC...Diagnosis B23 Foad Mashayekhi, Aaron S. Meyer, Stacey A. Shiigi, Vu Nguyen and Daniel T. Ka - 129 meL UCLA B24 Self-Assembly and DNA Binding Properties of...Journal of Immunclogy 165:3839­ 3848. 2Hannan JP, Young KA , Guthrid!le JM, Asokan R, Szakonyi G, Chen XJS, & Holers \\1M (2005) Journal of Molecular

Paul Davis Restoration Information Sheet

EPA Pesticide Factsheets

Paul Davis Restoration (the Company) is located in Nicholasville, Kentucky. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Lexington, Kentucky.

Rotational Rehybridization and the High Temperature Phase of UC2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wen, Xiaodong; Rudin, Sven P.; Batista, Enrique R.

2012-12-03

The screened hybrid approximation (HSE) of density functional theory (DFT) is used to examine the structural, optical, and electronic properties of the high temperature phase, cubic UC(2). This phase contains C(2) units with a computed C-C distance of 1.443 Å which is in the range of a CC double bond; U is formally 4+, C(2) 4-. The closed shell paramagnetic state (NM) was found to lie lowest. Cubic UC(2) is found to be a semiconductor with a narrow gap, 0.4 eV. Interestingly, the C(2) units connecting two uranium sites can rotate freely up to an angle of 30°, indicating amore » hindered rotational solid. Ab-initio molecular dynamic simulations (HSE) show that the rotation of C(2) units in the low temperature phase (tetragonal UC(2)) occurs above 2000 K, in good agreement with experiment. The computed energy barrier for the phase transition from tetragonal UC(2) to cubic UC(2) is around 1.30 eV per UC(2). What is fascinating about this system is that at high temperature, the phase transformation to the cubic phase is associated with a rehybridization of the C atoms from sp to sp(3).« less

48 CFR 1322.404 - Davis-Bacon Act wage determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Davis-Bacon Act wage determination. 1322.404 Section 1322.404 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Involving Construction 1322.404 Davis-Bacon Act wage determination. ...

76 FR 49664 - Safety Zone; M/V DAVY CROCKETT, Columbia River

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

...-AA00 Safety Zone; M/V DAVY CROCKETT, Columbia River AGENCY: Coast Guard, DHS. ACTION: Temporary final... waters of the Columbia River surrounding the M/ V DAVY CROCKETT at approximate river mile 117. The... operations involving the M/ V DAVY CROCKETT. All persons and vessels are prohibited from entering or...

Successful affiliations: principles and practices.

PubMed

Rice, Ann Madden

2011-01-01

An affiliation can help a healthcare provider prepare for the challenges of healthcare reform, the rapidly changing landscapes of the commercial insurance industry, and the public's expectations about service and quality. UC Davis Medical Center, a 645-bed tertiary hospital in Sacramento, California, with many hospital-based clinics and a community-based group of primary care clinics, has developed a number of principles for affiliation. These principles are based on its experience in legal and financial affiliations with an academic practice group, with individual and small groups of primary care physicians, and with community hospitals around oncology services linked with U.C. Davis' National Cancer Institute-designated cancer center. This article offers a process for evaluating the appropriateness of an affiliation. The chances for a successful affiliation improve if each party has indicated the value it hopes to derive and how to measure that value, has communicated with all affected constituents, and has an agreed-upon method for resolving disputes.

48 CFR 1422.404 - Davis-Bacon Act wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Davis-Bacon Act wage determinations. 1422.404 Section 1422.404 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... Involving Construction 1422.404 Davis-Bacon Act wage determinations. ...

48 CFR 22.404 - Davis-Bacon Act wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Davis-Bacon Act wage... Involving Construction 22.404 Davis-Bacon Act wage determinations. The Department of Labor is responsible for issuing wage determinations reflecting prevailing wages, including fringe benefits. The wage...

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions.

PubMed

Damian, Festo; Fabian, Judit; Friend, David R; Kiser, Patrick F

2010-08-30

In this work, we evaluated the chemical stability profiles of UC781 based solutions to identify excipients that stabilize the microbicidal agent UC781. When different antioxidants were added to UC781 in sulfobutylether-beta-cyclodextrin (SBE-beta-CD) solutions and subjected to a 50 degrees C stability study, it was observed that EDTA was a better stabilizing agent than sodium metabisulfite, glutathione or ascorbic acid. Some antioxidants accelerated the degradation of UC781, suggesting metal-catalyzed degradation of UC781. Furthermore, we observed substantial degradation of UC781 when stored in 1% Tween 80 and 1% DMSO solutions alone or in those with 10mM EDTA. On the other hand, improved stability of UC781 in the presence of 100 and 200mM of EDTA was observed in these solutions. The addition of both EDTA and citric acid in the stock solutions resulted in recovery of more than 60% of UC781 after 12 weeks. Generally, 10% SBE-beta-CD in the presence of EDTA and citric acid stabilized UC781 solutions: the amount of UC781 recovered approaching 95% after 12 weeks of storage at 40 degrees C. We also showed that the desulfuration reaction of the UC781 thioamide involves oxygen by running solution stability studies in deoxygenated media. Improved stability of UC781 in the present study indicates that the incorporation of EDTA, citric acid and SBE-beta-CD and the removal of oxygen in formulations of this drug will aid in increasing the stability of UC781 where solutions of the drug are required. Published by Elsevier B.V.

Astronaut Jan Davis monitors Commercial Protein Crystal Growth experiment

NASA Image and Video Library

1994-02-03

STS060-21-031 (3-11 Feb 1994) --- Using a lap top computer, astronaut N. Jan Davis monitors systems for the Commercial Protein Crystal Growth (CPCG) experiment onboard the Space Shuttle Discovery. Davis joined four other NASA astronauts and a Russian cosmonaut for eight days in space aboard Discovery.

Mark F. Davis | NREL

Science.gov Websites

| 303-384-6140 Orcid ID http://orcid.org/0000-0003-4541-9852 Research Interests Dr. Mark Davis is the years, he has served as the Platform Program Manager for Thermochemical and has directed research Science Center, including high throughput recalcitrance assays, omics research, computational modeling

The Aging of a Great Woman from Florida: Wilma E. Davis

ERIC Educational Resources Information Center

Lumadue, Richard

2011-01-01

This paper deals with aging of a remarkable woman from Florida, Wilma E. Davis. After ministering in the Methodist church for over 30 years as the first ordained Methodist minister in the state of Florida, Davis retired and began a PhD program at Boston University at the age of 63. Davis completed her PhD at the age of 68. The pursuit of her…

Writing in the Margins: An Interview with Bob Davis

ERIC Educational Resources Information Center

Locke, Kirsten

2017-01-01

Bob Davis is Editor of the "Journal of Philosophy of Education" and is Head of School and Professor of Religious and Cultural Education in the School of Education Administration at the University of Glasgow. In this interview Davis provides his insight on topics such as the role of learned societies in philosophy of education,…

UC DAVIS CENTER FOR CHILDREN’S ENVIRONMENTAL HEALTH

EPA Science Inventory

The goals of the CCEH in the next five years are to: (1) better understand the mechanisms by which environmental, immunologic, and molecular factors interact to influence the risk and severity of autism; (2) identify early immunologic, environmental, and genomic markers of sus...

Towards component-based validation of GATE: aspects of the coincidence processor

PubMed Central

Moraes, Eder R.; Poon, Jonathan K.; Balakrishnan, Karthikayan; Wang, Wenli; Badawi, Ramsey D.

2014-01-01

GATE is public domain software widely used for Monte Carlo simulation in emission tomography. Validations of GATE have primarily been performed on a whole-system basis, leaving the possibility that errors in one sub-system may be offset by errors in others. We assess the accuracy of the GATE PET coincidence generation sub-system in isolation, focusing on the options most closely modeling the majority of commercially available scanners. Independent coincidence generators were coded by teams at Toshiba Medical Research Unit (TMRU) and UC Davis. A model similar to the Siemens mCT scanner was created in GATE. Annihilation photons interacting with the detectors were recorded. Coincidences were generated using GATE, TMRU and UC Davis code and results compared to “ground truth” obtained from the history of the photon interactions. GATE was tested twice, once with every qualified single event opening a time window and initiating a coincidence check (the “multiple window method”), and once where a time window is opened and a coincidence check initiated only by the first single event to occur after the end of the prior time window (the “single window method”). True, scattered and random coincidences were compared. Noise equivalent count rates were also computed and compared. The TMRU and UC Davis coincidence generators agree well with ground truth. With GATE, reasonable accuracy can be obtained if the single window method option is chosen and random coincidences are estimated without use of the delayed coincidence option. However in this GATE version, other parameter combinations can result in significant errors. PMID:25240897

Bolden Visit Davis Elementary

NASA Image and Video Library

2009-09-10

NASA Administrator Charles F. Bolden speaks to students during a visit to Davis Elementary School, Friday, Sept. 11, 2009, in Washington. Bolden spent time with approximately 120 students in third, fourth and fifth grade talking about science, technology, mathematics and engineering as part of the National Day of Service and Remembrance. Photo Credit: (NASA/Paul E. Alers)

Reduced risk of UC in families affected by appendicitis: a Danish national cohort study.

PubMed

Nyboe Andersen, Nynne; Gørtz, Sanne; Frisch, Morten; Jess, Tine

2017-08-01

The possible aetiological link between appendicitis and UC remains unclear. In order to investigate the hereditary component of the association, we studied the risk of UC in family members of individuals with appendicitis. A cohort of 7.1 million individuals was established by linkage of national registers in Denmark with data on kinship and diagnoses of appendicitis and UC. Poisson regression models were used to calculate first hospital contact rate ratios (RR) for UC with 95% CIs between individuals with or without relatives with a history of appendicitis. During 174 million person-years of follow-up between 1977 and 2011, a total of 190 004 cohort members developed appendicitis and 45 202 developed UC. Individuals having a first-degree relative with appendicitis before age 20 years had significantly reduced risk of UC (RR 0.90; 95% CI 0.86 to 0.95); this association was stronger in individuals with a family predisposition to UC (RR 0.66; 95% CI 0.51 to 0.83). Individuals with a first-degree relative diagnosed with appendicitis before age 20 years are at reduced risk of UC, particularly when there is a family predisposition to UC. Our findings question a previously hypothesised direct protective influence of appendicitis on inflammation of the large bowel. Rather, genetic or environmental factors linked to an increased risk of appendicitis while being protective against UC may explain the repeatedly reported reduced relative risk of UC in individuals with a history of appendicitis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Jefferson Davis and the Failure of Confederate Military Strategy, 1861-1865

DTIC Science & Technology

2010-04-14

schools in Mississippi, Samuel decided to send Jefferson to Kentucky when he was old enough to attend school. At the age of eight, he enrolled him at...alone on a steamboat at the age of ten. Back in Mississippi, Davis briefly attended Jefferson College near Natchez before entering Wilkinson Academy...the fields. Davis decided on his own that school had its merits and returned to Wilkinson.9 In 1823 at the age of fifteen Davis enrolled in

Strategies to prevent and reduce diabetes and obesity in Sacramento, California: the African American Leadership Coalition and University of California, Davis.

PubMed

Ziegahn, Linda; Styne, Dennis; Askia, Joyce; Roberts, Tina; Lewis, Edward T; Edwards, Whitney

2013-11-14

Diabetes is one of the leading causes of illness and death for African Americans and people of African descent throughout the United States and in the city and county of Sacramento, California. The involvement of families and communities in developing prevention strategies can increase the likelihood that behavioral changes will be sustained. Three member organizations of the African American Leadership Coalition (AALC) entered into a partnership with the University of California, Davis (UC Davis) to engage families in developing a process to identify barriers to diabetes and obesity prevention and reduction, exchange strategies, and create action plans for prevention. The intervention comprised 3 phases: 1) coalition formation and training; 2) data collection, analysis, and dissemination of results; and 3) development of family and community action plans. Academic and community partners planned and implemented all project phases together. Sources of information about diabetes and obesity were primarily doctors and the Internet; barriers were related to lack of time needed to prepare healthy meals, high food costs, transportation to fresh markets, motivation around healthy habits, and unsafe environments. Action plans addressed behavioral change and family cohesion. The group discussion format encouraged mutual support and suggestions for better eating and physical exercise habits. This collaborative partnership model can strengthen existing group relationships or promote new affiliations that form the basis for future action coalitions. Participants worked both within and across groups to exchange information, stories of success and challenges, and specific health improvement strategies.

Undergraduate Field Courses in Volcanology at the University of California, Davis

NASA Astrophysics Data System (ADS)

Schiffman, P.

2002-05-01

At U.C. Davis, undergraduate Geology majors have two opportunities to participate in extended field courses in volcanology: (1) all majors spend one week in a volcanology module during their six-week, "capstone" Summer Field Geology (GEL 110) course, and (2) all majors may enroll in a two-week, Introductory Volcanology course (GEL 138) offered each summer at Kilauea Volcano. The former course is required of all majors in order to fulfill their B.S. degree requirements, whereas the latter fulfills upper division elective units for either the B.A. or B.S. degree in Geology. The volcanology module in GEL 110 is based at U.C.'s White Mountain Research Station in Bishop, California and includes four separate exercises: (1) mapping patterns of consolidation of tephra at the Black Point tuff cone in order to understand the processes of palagonitization, (2) contouring graphic mean and sorting for tephra collected from the Red Cones cinder cone to understand Strombolian processes, (3) measuring a stratigraphic section of the Bishop Tuff in the lower Owens River Gorge to differentiate cooling units in ignimbrites, and (4) mapping the relationships amongst pumice units and obsidian at the Glass Mountain flow to understand evolution of silicic flows. Most exercises require laboratory measurements for grain size or density (Mayfield and Schiffman, 1998). GEL 138, based at the Kilauea Military Camp, includes a daily schedule of morning lectures and afternoon field excursions and exercises. Exercises include: (1) measuring a stratigraphic section of the Keanakako'i Ash Member to interpret pre-1790 periods of hydrovolcanism, (2) measuring and contouring ground temperatures in the Steaming Bluffs thermal area (3) conducting granulometric measurements of tephra from the Nanawale sand hills to understand the genesis of littoral cones, (4) mapping of soil pH around the perimeter of Kilauea Caldera to illuminate climatic effects (i.e.,vog and wind patterns) on the summit region, and

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR Sec. 14 - Anti-Kickback and Davis-Bacon Acts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 14 Anti-Kickback and Davis-Bacon Acts. (a) All work awarded under the NSA-LUMPSUMREP Contract is... thereby is not subject to the Davis-Bacon Act). Article 24 of the NSA-LUMPSUMREP Contract requires the...

46 CFR Sec. 14 - Anti-Kickback and Davis-Bacon Acts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 14 Anti-Kickback and Davis-Bacon Acts. (a) All work awarded under the NSA-LUMPSUMREP Contract is... thereby is not subject to the Davis-Bacon Act). Article 24 of the NSA-LUMPSUMREP Contract requires the...

46 CFR Sec. 14 - Anti-Kickback and Davis-Bacon Acts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 14 Anti-Kickback and Davis-Bacon Acts. (a) All work awarded under the NSA-LUMPSUMREP Contract is... thereby is not subject to the Davis-Bacon Act). Article 24 of the NSA-LUMPSUMREP Contract requires the...

46 CFR Sec. 14 - Anti-Kickback and Davis-Bacon Acts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 14 Anti-Kickback and Davis-Bacon Acts. (a) All work awarded under the NSA-LUMPSUMREP Contract is... thereby is not subject to the Davis-Bacon Act). Article 24 of the NSA-LUMPSUMREP Contract requires the...

46 CFR Sec. 14 - Anti-Kickback and Davis-Bacon Acts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ACCOMPLISHMENT OF VESSEL REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 14 Anti-Kickback and Davis-Bacon Acts. (a) All work awarded under the NSA-LUMPSUMREP Contract is... thereby is not subject to the Davis-Bacon Act). Article 24 of the NSA-LUMPSUMREP Contract requires the...

[Sir Humphry Davy, the discoverer of anesthetic action of nitrous oxide--Davy and poets of British Romanticism and inhalation of laughing gas by his friends].

PubMed

Fujita, T

1998-01-01

In "Dove Cottage", the old house of the poet laureate William Wordsworth (1770-1850) in Grasmere, England, there is a portrait of Sir Humphry Davy (1778-1829). In 1804, Wordsworth invited his young friend to his home. Davy's works in the field of chemistry are well known. Interestingly enough, once he wished he could be a poet. His future seemed to be prosperous and delightful. He was highly evaluated by Robert Southey, poet laureate. But he has chosen the way of chemist. The author found some facts from literatures and received some information by courtesy of the Wordsworth Trust, Centre for British Romanticism. Davy's life and his works were introduced chronologically.

Bolden Visit Davis Elementary

NASA Image and Video Library

2009-09-10

NASA Administrator Charles F. Bolden reads a passage from the book "Can You Fly High Wright Brothers?" while visiting with students at Davis Elementary School, Friday, Sept. 11, 2009, in Washington. Bolden spent time with approximately 120 students in third, fourth and fifth grade talking about science, technology, mathematics and engineering as part of the National Day of Service and Remembrance. Photo Credit: (NASA/Paul E. Alers)

40 Years in Applied Linguistics: An Interview with Alan Davies

ERIC Educational Resources Information Center

Kunnan, Antony John

2005-01-01

This article presents an interview with Professor Alan Davies who was born in Wales, studied at Oxford University and Birmingham University, and taught in Scotland at the University of Edinburgh, completing 40 years this year. Professor Davies has travelled widely to give invited talks and seminars, participate in applied linguistics conferences,…

77 FR 13328 - Federal Acquisition Regulation; Information Collection; Davis Bacon Act-Price Adjustment (Actual...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

...; Information Collection; Davis Bacon Act--Price Adjustment (Actual Method) AGENCY: Department of Defense (DOD... approved information collection requirement concerning the Davis-Bacon Act price adjustment (actual method... Information Collection 9000- 0154, Davis Bacon Act--Price Adjustment (Actual Method), by any of the following...

[Medical therapy of inflammatory bowel diseases: ulcerative colitis].

PubMed

Lakatos, László; Lakatos, Péter László

2007-06-24

There are fewer significant changes in the medical therapy of ulcerative colitis (UC) compared to Crohn's disease. The most important factors that determine therapy are disease extent and severity. 5-aminosalicylates (5-ASA) constitute the treatment of choice in mild-to-moderate UC. The efficacy of new compounds (e.g. mesalazine) is only mildly improved compared to sulphasalazine; however, their use has become more frequent due to a more favorable side effects profile. Topical medication is more effective in proctitis and distal colitis, and the combination of topical and orally-administered drugs is superior to oral therapy alone also in extensive disease. Thus, this latter regimen should be considered for cases where the escalation of treatment is required. Systemic steroids still represent the first line therapy in acute, severe UC, while in patients who do not respond to steroids, cyclosporine and infliximab should be considered as a second line therapy and as alternatives for colectomy. Maintenance treatment is indicated in all UC cases. 5-ASA compounds are suggested as first line maintenance therapy with the optimal dose still being under investigation. Topical compounds are effective also for maintenance in distal colitis or proctitis, if accepted by the patients. Immunosuppressives, especially azathioprine, should be considered in chronically active, steroid dependent or resistant patients. According to recent publications, azathioprine is almost equally effective in UC and CD. The question of chemoprevention is important during maintenance. There are increasing data supporting the notion that aminosalicylates may lower the risk for UC-associated colorectal cancer. The most important changes in the management of UC are the more frequent use of topical aminosalicylates and azathioprine, the availability of infliximab in severe UC, and increasing use of aminosalicylates for chemoprevention of colorectal carcinoma. Furthermore, adequate attention is needed to

46 CFR 54.25-10 - Low temperature operation-ferritic steels (replaces UCS-65 through UCS-67).

Code of Federal Regulations, 2013 CFR

2013-10-01

... the following additional requirements: Note: For high alloy steels refer to § 54.25-15. For heat... tempered steels. The ultimate and yield strengths shall be as shown in the applicable specification and... 46 Shipping 2 2013-10-01 2013-10-01 false Low temperature operation-ferritic steels (replaces UCS...

46 CFR 54.25-10 - Low temperature operation-ferritic steels (replaces UCS-65 through UCS-67).

Code of Federal Regulations, 2014 CFR

2014-10-01

... the following additional requirements: Note: For high alloy steels refer to § 54.25-15. For heat... tempered steels. The ultimate and yield strengths shall be as shown in the applicable specification and... 46 Shipping 2 2014-10-01 2014-10-01 false Low temperature operation-ferritic steels (replaces UCS...

46 CFR 54.25-10 - Low temperature operation-ferritic steels (replaces UCS-65 through UCS-67).

Code of Federal Regulations, 2012 CFR

2012-10-01

... the following additional requirements: Note: For high alloy steels refer to § 54.25-15. For heat... tempered steels. The ultimate and yield strengths shall be as shown in the applicable specification and... 46 Shipping 2 2012-10-01 2012-10-01 false Low temperature operation-ferritic steels (replaces UCS...

ETV REPORT - EVALUATION OF DAVIS TECHNOLOGIES INTERNATIONAL CORP. - INDUSTRIAL WASTEWATER TREATMENT PLANT

EPA Science Inventory

Abstract: Evaluation of Davis Technologies International Corp. Industrial Wastewater Treatment Plant

The Davis Technologies International Corp. (DTIC) Industrial Wastewater Treatment Plant (IWTP) was tested, under actual production conditions, processing metalworking and ...

Towards component-based validation of GATE: aspects of the coincidence processor.

PubMed

Moraes, Eder R; Poon, Jonathan K; Balakrishnan, Karthikayan; Wang, Wenli; Badawi, Ramsey D

2015-02-01

GATE is public domain software widely used for Monte Carlo simulation in emission tomography. Validations of GATE have primarily been performed on a whole-system basis, leaving the possibility that errors in one sub-system may be offset by errors in others. We assess the accuracy of the GATE PET coincidence generation sub-system in isolation, focusing on the options most closely modeling the majority of commercially available scanners. Independent coincidence generators were coded by teams at Toshiba Medical Research Unit (TMRU) and UC Davis. A model similar to the Siemens mCT scanner was created in GATE. Annihilation photons interacting with the detectors were recorded. Coincidences were generated using GATE, TMRU and UC Davis code and results compared to "ground truth" obtained from the history of the photon interactions. GATE was tested twice, once with every qualified single event opening a time window and initiating a coincidence check (the "multiple window method"), and once where a time window is opened and a coincidence check initiated only by the first single event to occur after the end of the prior time window (the "single window method"). True, scattered and random coincidences were compared. Noise equivalent count rates were also computed and compared. The TMRU and UC Davis coincidence generators agree well with ground truth. With GATE, reasonable accuracy can be obtained if the single window method option is chosen and random coincidences are estimated without use of the delayed coincidence option. However in this GATE version, other parameter combinations can result in significant errors. Copyright © 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

PubMed

Cranenburg, Ellen C M; Brandenburg, Vincent M; Vermeer, Cees; Stenger, Melanie; Mühlenbruch, Georg; Mahnken, Andreas H; Gladziwa, Ulrich; Ketteler, Markus; Schurgers, Leon J

2009-02-01

Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a potent local inhibitor of cardiovascular calcification and accumulates at areas of calcification in its uncarboxylated form (ucMGP). We previously found significantly lower circulating ucMGP levels in patients with a high vascular calcification burden. Here we report on the potential of circulating ucMGP to serve as a biomarker for vascular calcification in haemodialysis (HD) patients. Circulating ucMGP levels were measured with an ELISA-based assay in 40 HD patients who underwent multi-slice computed tomography (MSCT) scanning to quantify the extent of coronary artery calcification (CAC). The mean ucMGP level in HD patients (193 +/- 65 nM) was significantly lower as compared to apparently healthy subjects of the same age (441 +/- 97 nM; p < 0.001) and patients with rheumatoid arthritis (RA) without CAC (560 +/- 140 nM; p < 0.001). Additionally, ucMGP levels correlated inversely with CAC scores (r = -0.41; p = 0.009), and this correlation persisted after adjustment for age, dialysis vintage and high-sensitivity C-reactive protein (hs-CRP). Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification.

Strategies to Prevent and Reduce Diabetes and Obesity in Sacramento, California: The African American Leadership Coalition and University of California, Davis

PubMed Central

Styne, Dennis; Askia, Joyce; Roberts, Tina; Lewis, Edward T.; Edwards, Whitney

2013-01-01

Background Diabetes is one of the leading causes of illness and death for African Americans and people of African descent throughout the United States and in the city and county of Sacramento, California. The involvement of families and communities in developing prevention strategies can increase the likelihood that behavioral changes will be sustained. Context Three member organizations of the African American Leadership Coalition (AALC) entered into a partnership with the University of California, Davis (UC Davis) to engage families in developing a process to identify barriers to diabetes and obesity prevention and reduction, exchange strategies, and create action plans for prevention. Methods The intervention comprised 3 phases: 1) coalition formation and training; 2) data collection, analysis, and dissemination of results; and 3) development of family and community action plans. Academic and community partners planned and implemented all project phases together. Outcomes Sources of information about diabetes and obesity were primarily doctors and the Internet; barriers were related to lack of time needed to prepare healthy meals, high food costs, transportation to fresh markets, motivation around healthy habits, and unsafe environments. Action plans addressed behavioral change and family cohesion. The group discussion format encouraged mutual support and suggestions for better eating and physical exercise habits. Interpretation This collaborative partnership model can strengthen existing group relationships or promote new affiliations that form the basis for future action coalitions. Participants worked both within and across groups to exchange information, stories of success and challenges, and specific health improvement strategies. PMID:24229570

Expression characteristics of long noncoding RNA uc.322 and its effects on pancreatic islet function.

PubMed

Zhao, Xiaoqin; Rong, Can; Pan, Fenghui; Xiang, Lizhi; Wang, Xinlei; Hu, Yun

2018-06-28

Increasing evidence indicates that long noncoding RNAs (lncRNAs) perform special biological functions by regulating gene expression through multiple pathways and molecular mechanisms. The aim of this study was to explore the expression characteristics of lncRNA uc.322 in pancreatic islet cells and its effects on the secretion function of islet cells. Bioinformatics analysis was used to detect the lncRNA uc.322 sequence, location, and structural features. Expression of lncRNA uc.322 in different tissues was detected by quantitative polymerase chain reaction analyses. Quantitative polymerase chain reaction, Western blot analysis, adenosine triphosphate determination, glucose-stimulated insulin secretion, and enzyme-linked immunosorbent assay were used to evaluate the effects of lncRNA uc.322 on insulin secretion. The results showed that the full-length of lncRNA uc.322 is 224 bp and that it is highly conserved in various species. Bioinformatics analysis revealed that lncRNA uc.322 is located on chr7:122893196-122893419 (GRCH37/hg19) within the SRY-related HMG-box 6 gene exon region. Compared with other tissues, lncRNA uc.322 is highly expressed in pancreatic tissue. Upregulation of lncRNA uc.322 expression increases the insulin transcription factors pancreatic and duodenal homeobox 1 and Forkhead box O1 expression, promotes insulin secretion in the extracellular fluid of Min6 cells, and increases the adenosine triphosphate concentration. On the other hand, knockdown of lncRNA uc.322 has opposite effects on Min6 cells. Overall, this study showed that upregulation of lncRNA uc.322 in islet β-cells can increase the expression of insulin transcription factors and promote insulin secretion, and it may be a new therapeutic target for diabetes. © 2018 Wiley Periodicals, Inc.

Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans

PubMed Central

Schultz, Douglas H.; Balderston, Nicholas L.; Geiger, Jennifer A.; Helmstetter, Fred J.

2014-01-01

The nature of the relationship between explicit and implicit learning is a topic of considerable debate. In order to investigate this relationship we conducted two experiments on postconditioning revaluation of the unconditional stimulus (UCS) in human fear conditioning. In Experiment 1, the intensity of the UCS was decreased following acquisition for one group (devaluation) and held constant for another group (control). A subsequent test revealed that even though both groups exhibited similar levels of UCS expectancy, the devaluation group had significantly smaller conditional skin conductance responses. The devaluation effect was not explained by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS intensity had changed. In Experiment 2, the value of the UCS was increased following acquisition for one group (inflation) and held constant for another group (control). Test performance revealed that UCS inflation did not alter expectancy ratings, but the inflation group exhibited larger learned skin conductance responses than the control group. The inflation effect was not explained by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS intensity had changed. The SCR revaluation effect was not dependent on explicit memory processes in either experiment. In both experiments we found differences on an implicit measure of learning in the absence of changes in explicit measures. Together, the differences observed between expectancy measures and skin conductance support the idea that these responses might reflect different types of memory formed during the same training procedure and be supported by separate neural systems. PMID:23731073

The eye disease of Jefferson Davis (1808-1889).

PubMed

Hertle, Richard W; Spellman, Robert

2007-01-01

The only Confederate president, Jefferson Davis, led a long and eventful life. He was a Mississippi planter, a husband, a father, West Point graduate, war hero, congressman, senator, secretary of war, and finally President of the Confederate States of America. In many ways he was a study of contrast with his northern counterpart Abraham Lincoln. Davis was personally courageous and a rich, educated, southern aristocrat who did not deeply understand the political process or have the refined personal skills necessary to work well with others. Prior to his Presidency he served with distinction in two wars, but as a result of his confederate activity and pro-slavery philosophy he is one of the least discussed famous Americans. Davis's health was a constant problem and he suffered an almost fatal attack of 'malaria' in 1836. In the winter of 1857-1858, he again was seriously ill and by the end of February 1858, a chronic, relapsing, ocular inflammatory condition began. Using historical evidence from multiple sources, this paper will propose a diagnosis of the Confederate President's ocular condition and consider how this could have influenced his military and political decisions.

The eye disease of Jefferson Davis (1808-1889).

PubMed

Hertle, Richard W; Spellman, Robert

2006-01-01

The only Confederate president, Jefferson Davis, led a long and eventful life. He was a Mississippi planter, a husband, a father, West Point graduate, war hero, congressman, senator, secretary of war, and finally President of the Confederate States of America. In many ways he was a study of contrast with his northern counterpart, Abraham Lincoln. Davis was personally courageous and a rich, educated, southern aristocrat who did not deeply understand the political process or have the refined personal skills necessary to work well with others. Prior to his Presidency he served with distinction in two wars, but as a result of his confederate activity and pro-slavery philosophy he is one of the least discussed famous Americans. Davis's health was a constant problem and he suffered an almost fatal attack of "malaria" in 1836. In the winter of 1857-1858 he again was seriously ill and by the end of February 1858 a chronic, relapsing, ocular inflammatory condition began. Using historical evidence from multiple sources, this paper will propose a diagnosis of the Confederate President's ocular condition and consider how this could have influenced his military and political decisions.

Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs.

PubMed

Deparle, L A; Gupta, R C; Canerdy, T D; Goad, J T; D'Altilio, M; Bagchi, M; Bagchi, D

2005-08-01

DeParle L. A., Gupta R. C., Canerdy T. D., Goad J. T., D'Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J. vet. Pharmacol. Therap.28, 385-390. In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs. Fifteen dogs in three groups received either no UC-II (Group I) or UC-II with 1 mg/day (Group II) or 10 mg/day (Group III) for 90 days. Lameness and pain were measured on a weekly basis for 120 days (90 days treatment plus 30 days post-treatment). Blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury). Dogs receiving 1 mg or 10 mg UC-II/day for 90 days showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion, with 10 mg showed greater improvement. At either dose of UC-II, no adverse effects were noted and no significant changes were noted in serum chemistry, suggesting that UC-II was well tolerated. In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following UC-II withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation. These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.

A Systematic Theoretical Study of UC6: Structure, Bonding Nature, and Spectroscopy.

PubMed

Du, Jiguang; Jiang, Gang

2017-11-20

The study of uranium carbides has received renewed attention in recent years due to the potential use of these compounds as fuels in new generations of nuclear reactors. The isomers of the UC 6 cluster were determined by DFT and ab initio methods. The structures obtained using SC-RECP for U were generally consistent with those obtained using an all-electron basis set (ZORA-SARC). The CCSD(T) calculations indicated that two isomers had similar energies and may coexist in laser evaporation experiments. The nature of the U-C bonds in the different isomers was examined via a topological analysis of the electron density, and the results indicated that the U-C bonds are predominantly closed-shell (ionic) interactions with a certain degree of covalent character in all cases, particularly in the linear species. The IR and UV-vis spectra of the isomers were theoretically simulated to provide information that can be used to identify the isomers of UC 6 in future experiments.

The Failure of Scientific Medicine: Davis Inlet as an Example of Sociopolitical Morbidity

PubMed Central

Scott, Richard T.; Conn, Selina

1987-01-01

The social and economic history of a Labrador coastal town is reviewed with particular reference to the roles of the Church, the Hudson's Bay Company, and the medical profession. Objective indicators of the current health status of the community are presented, and the major causes of ill-health in Davis Inlet are discussed. Comparison is made with Rudolph Virchow's assessment of the causes of a typhoid epidemic in Upper Silesia in 1848. The subsequent evolution of medicine from a socio-political to a scientific model is reviewed briefly. The authors conclude that the medical profession has embraced the scientific model to the point of virtually excluding the socio-political one, even though social, political, economic, and cultural alienation remain major causes of morbidity and mortality. In so doing, the profession promotes ill-health. PMID:21263779

Robotic cholecystectomy and resident education: the UC Davis experience.

PubMed

Nelson, Eric C; Gottlieb, Andrea H; Müller, Hans-Georg; Smith, William; Ali, Mohamed R; Vidovszky, Tamas J

2014-06-01

The popularity of robotic surgery highlights the need for strategies to integrate this technique into surgical education. We present 5 year data for robotic cholecystectomy (RC) as a model for training residents. Data were collected on all RC over 66 months. Duration for docking the robot (S2) and performing RC (S3), and surgical outcomes, were recorded. We used a linear mixed effects model to investigate learning curves. Thirty-eight trainees performed 160 RCs, with most performing more than four. One case was aborted due to haemodynamic instability, and two were converted to open surgery due to adhesions. There were no technical complications. The duration of S2 (mean = 6.2 ± 3.6 min) decreased considerably (p = 0.027). Trainees also demonstrated decrease in duration of S3 (mean = 38.4 ± 15.4 min), indicating improvement in technique (p = 0.008). RC is an effective model for teaching residents. Significant and reproducible improvement can be realized with low risk of adverse outcomes. Copyright © 2013 John Wiley & Sons, Ltd.

Quantification of process variables for carbothermic synthesis of UC1-xNx fuel microspheres

NASA Astrophysics Data System (ADS)

Lindemer, T. B.; Silva, C. M.; Henry, J. J.; McMurray, J. W.; Voit, S. L.; Collins, J. L.; Hunt, R. D.

2017-01-01

This report details the continued investigation of process variables involved in converting sol-gel-derived, urania-carbon microspheres to ∼820-μm-dia. UC1-xNx fuel kernels in flow-through, vertical Mo and W crucibles at temperatures up to 2123 K. Experiments included calcining of air-dried UO3-H2O-C microspheres in Ar and H2-containing gases, conversion of the resulting UO2-C kernels to dense UO2:2UC in the same gases and vacuum, and its conversion in N2 to UC1-xNx (x = ∼0.85). The thermodynamics of the relevant reactions were applied extensively to interpret and control the process variables. Producing the precursor UO2:2UC kernel of ∼96% theoretical density was required, but its subsequent conversion to UC1-xNx at 2123 K was not accompanied by sintering and resulted in ∼83-86% of theoretical density. Increasing the UC1-xNx kernel nitride component to ∼0.98 in flowing N2-H2 mixtures to evolve HCN was shown to be quantitatively consistent with present and past experiments and the only useful application of H2 in the entire process.

Fort Davis National Historic Site : acoustical monitoring

DOT National Transportation Integrated Search

2013-06-01

During the summer of 2010 (September - October 2010), the Volpe Center collected baseline acoustical data at Fort Davis National Historic Site (FODA)at two sites deployed for approximately 30 days each. The baseline data collected during this period ...

Laboratory Management Institute: A Model for the Professional Development of Scientists

ERIC Educational Resources Information Center

Galland, John C.; McCutcheon, Jade R.; Chronister, Lynne U.

2008-01-01

The Laboratory Management Institute (LMI) at the University of California, Davis (UC Davis) was an experiment designed to enhance the leadership and management skills of researchers and thereby enhance the overall quality of the academic research enterprise. The educational programs that resulted provide examples of how research administrators can…

Lack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaques.

PubMed

McConville, Christopher; Smith, James M; McCoy, Clare F; Srinivasan, Priya; Mitchell, James; Holder, Angela; Otten, Ron A; Butera, Salvatore; Doncel, Gustavo F; Friend, David R; Malcolm, R Karl

2015-02-01

This study describes the preclinical development of a matrix-type silicone elastomer vaginal ring device designed to provide controlled release of UC781, a non-nucleoside reverse transcriptase inhibitor. Testing of both human- and macaque-sized rings in a sink condition in vitro release model demonstrated continuous UC781 release in quantities considered sufficient to maintain vaginal fluid concentrations at levels 82-860-fold higher than the in vitro IC50 (2.0 to 10.4 nM) and therefore potentially protect against mucosal transmission of HIV. The 100-mg UC781 rings were well tolerated in pig-tailed macaques, did not induce local inflammation as determined by cytokine analysis and maintained median concentrations in vaginal fluids of UC781 in the range of 0.27 to 5.18 mM during the course of the 28-day study. Analysis of residual UC781 content in rings after completion of both the in vitro release and macaque pharmacokinetic studies revealed that 57 and 5 mg of UC781 was released, respectively. The pharmacokinetic analysis of a 100-mg UC781 vaginal ring in pig-tailed macaques showed poor in vivo-in vitro correlation, attributed to the very poor solubility of UC781 in vaginal fluid and resulting in a dissolution-controlled drug release mechanism rather than the expected diffusion-controlled mechanism.

Umbilical cord mesenchymal stem cell (UC-MSC) transplantations for cerebral palsy

PubMed Central

Dong, Huajiang; Li, Gang; Shang, Chongzhi; Yin, Huijuan; Luo, Yuechen; Meng, Huipeng; Li, Xiaohong; Wang, Yali; Lin, Ling; Zhao, Mingliang

2018-01-01

This study reports a case of a 4-year-old boy patient with abnormalities of muscle tone, movement and motor skills, as well as unstable gait leading to frequent falls. The results of the electroencephalogram (EEG) indicate moderately abnormal EEG, accompanied by irregular seizures. Based on these clinical characteristics, the patient was diagnosed with cerebral palsy (CP) in our hospital. In this study, the patient was treated with umbilical cord mesenchymal stem cell (UC-MSC) transplantation therapy. This patient received UC-MSC transplantation 3 times (5.3*107) in total. After three successive cell transplantations, the patient recovered well and showed obvious improvements in EEG and limb strength, motor function, and language expression. However, the improvement in intelligence quotient (IQ) was less obvious. These results indicate that UC-MSC transplantation is a promising treatment for cerebral palsy. PMID:29636880

UC Merced Center for Computational Biology Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colvin, Michael; Watanabe, Masakatsu

Final report for the UC Merced Center for Computational Biology. The Center for Computational Biology (CCB) was established to support multidisciplinary scientific research and academic programs in computational biology at the new University of California campus in Merced. In 2003, the growing gap between biology research and education was documented in a report from the National Academy of Sciences, Bio2010 Transforming Undergraduate Education for Future Research Biologists. We believed that a new type of biological sciences undergraduate and graduate programs that emphasized biological concepts and considered biology as an information science would have a dramatic impact in enabling the transformationmore » of biology. UC Merced as newest UC campus and the first new U.S. research university of the 21st century was ideally suited to adopt an alternate strategy - to create a new Biological Sciences majors and graduate group that incorporated the strong computational and mathematical vision articulated in the Bio2010 report. CCB aimed to leverage this strong commitment at UC Merced to develop a new educational program based on the principle of biology as a quantitative, model-driven science. Also we expected that the center would be enable the dissemination of computational biology course materials to other university and feeder institutions, and foster research projects that exemplify a mathematical and computations-based approach to the life sciences. As this report describes, the CCB has been successful in achieving these goals, and multidisciplinary computational biology is now an integral part of UC Merced undergraduate, graduate and research programs in the life sciences. The CCB began in fall 2004 with the aid of an award from U.S. Department of Energy (DOE), under its Genomes to Life program of support for the development of research and educational infrastructure in the modern biological sciences. This report to DOE describes the research and academic

A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.

PubMed

Luo, Yi-xiao; Xue, Yan-xue; Liu, Jian-feng; Shi, Hai-shui; Jian, Min; Han, Ying; Zhu, Wei-li; Bao, Yan-ping; Wu, Ping; Ding, Zeng-bo; Shen, Hao-wei; Shi, Jie; Shaham, Yavin; Lu, Lin

2015-07-14

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.

A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking

PubMed Central

Luo, Yi-xiao; Xue, Yan-xue; Liu, Jian-feng; Shi, Hai-shui; Jian, Min; Han, Ying; Zhu, Wei-li; Bao, Yan-ping; Wu, Ping; Ding, Zeng-bo; Shen, Hao-wei; Shi, Jie; Shaham, Yavin; Lu, Lin

2015-01-01

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts. PMID:26169171

75 FR 76498 - Firstenergy Nuclear Operating Company, Davis-Besse Nuclear Power Station; Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

... Company, Davis-Besse Nuclear Power Station; Environmental Assessment And Finding of No Significant Impact... operation of the Davis-Besse Nuclear Power Station, Unit 1 (DBNPS), located in Ottawa County, Ohio. In... the reactor coolant pressure boundary of light-water nuclear power reactors provide adequate margins...

Treatment of inflammatory bowel disease: A review of medical therapy

PubMed Central

Kozuch, Patricia L; Hanauer, Stephen B

2008-01-01

Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract. While a cure remains elusive, both can be treated with medications that induce and maintain remission. With the recent advent of therapies that inhibit tumor necrosis factor (TNF) alpha the overlap in medical therapies for UC and CD has become greater. Although 5-ASA agents have been a mainstay in the treatment of both CD and UC, the data for their efficacy in patients with CD, particularly as maintenance therapy, are equivocal. Antibiotics may have a limited role in the treatment of colonic CD. Steroids continue to be the first choice to treat active disease not responsive to other more conservative therapy; non-systemic steroids such as oral and rectal budesonide for ileal and right-sided CD and distal UC respectively are also effective in mild-moderate disease. 6-mercaptopurine (6-MP) and its prodrug azathioprine are steroid-sparing immunomodulators effective in the maintenance of remission of both CD and UC, while methotrexate may be used in both induction and maintenance of CD. Infliximab and adalimumab are anti-TNF agents approved in the US and Europe for the treatment of Crohn's disease, and infliximab is also approved for the treatment of UC. PMID:18200659

Genetic characterization of the UCS and Kex1 loci of Pneumocystis jirovecii.

PubMed

Esteves, F; Tavares, A; Costa, M C; Gaspar, J; Antunes, F; Matos, O

2009-02-01

Nucleotide variation in the Pneumocystis jirovecii upstream conserved sequence (UCS) and kexin-like serine protease (Kex1) loci was studied in pulmonary specimens from Portuguese HIV-positive patients. DNA was extracted and used for specific molecular sequence analysis. The number of UCS tandem repeats detected in 13 successfully sequenced isolates ranged from three (9 isolates, 69%) to four (4 isolates, 31%). A novel tandem repeat pattern and two novel polymorphisms were detected in the UCS region. For the Kex1 gene, the wild-type (24 isolates, 86%) was the most frequent sequence detected among the 28 sequenced isolates. Nevertheless, a nonsynonymous (1 isolate, 3%) and three synonymous (3 isolates, 11%) polymorphisms were detected and are described here for the first time.

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Requirement for postweld heat treatment (modifies UCS-56... for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon... the storage or transportation of liquefied compressed gases shall be postweld heat treated regardless...

Thermodynamic and experimental study of UC powders ignition

NASA Astrophysics Data System (ADS)

Le Guyadec, F.; Rado, C.; Joffre, S.; Coullomb, S.; Chatillon, C.; Blanquet, E.

2009-09-01

Mixed plutonium and uranium carbide (UPuC) is considered as a possible fuel material for future nuclear reactors. However, UPuC is pyrophoric and fine powders of UPuC are subject to temperature increase due to oxidation with air and possible ignition during conditioning and handling. In a first approach and to allow easier experimental conditions, this study was undertaken on uranium monocarbide (UC) with the aim to determine safe handling conditions for the production and reprocessing of uranium carbide fuels. The reactivity of uranium monocarbide in oxidizing atmosphere was studied in order to analyze the ignition process. Experimental thermogravimetric analysis (TGA) and differential thermal analysis (DTA) revealed that UC powder obtained by arc melting and milling is highly reactive in air at about 200 °C. The phases formed at the various observed stages of the oxidation process were analyzed by X-ray diffraction. At the same time, ignition was analyzed thermodynamically along isothermal sections of the U-C-O ternary diagram and the pressure of the gas produced by the UC + O 2 reaction was calculated. Two possible oxidation schemes were identified on the U-C-O phase diagram and assumptions are proposed concerning the overall oxidation and ignition paths. It is particularly important to understand the mechanisms involved since temperatures as high as 2500 °C could be reached, leading to CO(g) production and possibly to a blast effect.

Security Verification Techniques Applied to PatchLink COTS Software

NASA Technical Reports Server (NTRS)

Gilliam, David P.; Powell, John D.; Bishop, Matt; Andrew, Chris; Jog, Sameer

2006-01-01

Verification of the security of software artifacts is a challenging task. An integrated approach that combines verification techniques can increase the confidence in the security of software artifacts. Such an approach has been developed by the Jet Propulsion Laboratory (JPL) and the University of California at Davis (UC Davis). Two security verification instruments were developed and then piloted on PatchLink's UNIX Agent, a Commercial-Off-The-Shelf (COTS) software product, to assess the value of the instruments and the approach. The two instruments are the Flexible Modeling Framework (FMF) -- a model-based verification instrument (JPL), and a Property-Based Tester (UC Davis). Security properties were formally specified for the COTS artifact and then verified using these instruments. The results were then reviewed to determine the effectiveness of the approach and the security of the COTS product.

Internship Experiences Contribute to Confident Career Decision Making for Doctoral Students in the Life Sciences

ERIC Educational Resources Information Center

Schnoes, Alexandra M.; Caliendo, Anne; Morand, Janice; Dillinger, Teresa; Naffziger-Hirsch, Michelle; Moses, Bruce; Gibeling, Jeffery C.; Yamamoto, Keith R.; Lindstaedt, Bill; McGee, Richard; O'Brien, Theresa C.

2018-01-01

The Graduate Student Internships for Career Exploration (GSICE) program at the University of California, San Francisco (UCSF), offers structured training and hands-on experience through internships for a broad range of PhD-level careers. The GSICE program model was successfully replicated at the University of California, Davis (UC Davis). Here, we…

Results of Student-Generated 'Unique Characteristics' on the Medical Student Performance Evaluation.

PubMed

Holloway, Richard; Domack, Aaron; Treat, Robert; Roo, Koenraad De

2016-06-01

The Medical Student Performance Evaluation (MSPE)--formerly called the dean's letter--is an important tool for residency program directors to use in assessing student qualifications for both invitation to interview and construction of their rank order list. Many institutions are now allowing students to construct their own Unique Characteristics (UC) section for the MSPE. This study addresses the results of allowing students to construct their own UC. The goal of this study was to allow students to voice their thoughts regarding their participation in the construction of the UC section of the MSPE. The survey evaluated student attitude toward, value of, and support for the UC section. We conducted a cross-sectional survey of all fourth-year medical students at the Medical College of Wisconsin during the 2014-2015 academic year. Responses were received from 66% of students (133 out of 199). We developed a question bank to cover the aims of the study--to assess student perceived value, experience writing, and support for the UC section. There was agreement among students that their participation will positively affect their candidacy for interview selection and success in the match. Overall significance of regression model P = .001, R2. = .60. Additionally, students believed they had an advantage over applicants at other schools without the opportunity to draft their UC. Other findings included that men found the task more challenging, psychiatry applicants were least satisfied with the character count, and emergency medicine applicants voiced the lowest value for the UC section. The present study supports, in general terms, the utility and value of students drafting their own UC section of the MSPE. Future investigations should focus on expanding to other schools, comparing public to private institutions, and refining the interspecialty comparisons.

Experimental study of UC polycrystals in the prospect of improving the as-fabricated sample purity

NASA Astrophysics Data System (ADS)

Raveu, Gaëlle; Martin, Guillaume; Fiquet, Olivier; Garcia, Philippe; Carlot, Gaëlle; Palancher, Hervé; Bonnin, Anne; Khodja, Hicham; Raepsaet, Caroline; Sauvage, Thierry; Barthe, Marie-France

2014-12-01

Uranium and plutonium carbides are candidate fuels for Generation IV nuclear reactors. This study is focused on the characterization of uranium monocarbide samples. The successive fabrication steps were carried out under atmospheres containing low oxygen and moisture concentrations (typically less than 100 ppm) but sample transfers occurred in air. Six samples were sliced from four pellets elaborated by carbothermic reaction under vacuum. Little presence of UC2 is expected in these samples. The α-UC2 phase was indeed detected within one of these UC samples during an XRD experiment performed with synchrotron radiation. Moreover, oxygen content at the surface of these samples was depth profiled using a recently developed nuclear reaction analysis method. Large oxygen concentrations were measured in the first micron below the sample surface and particularly in the first 100-150 nm. UC2 inclusions were found to be more oxidized than the surrounding matrix. This work points out to the fact that more care must be given at each step of UC fabrication since the material readily reacts with oxygen and moisture. A new glovebox facility using a highly purified atmosphere is currently being built in order to obtain single phase UC samples of better purity.

Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis.

PubMed

Parian, Alyssa; Limketkai, Berkeley; Koh, Joyce; Brant, Steven R; Bitton, Alain; Cho, Judy H; Duerr, Richard H; McGovern, Dermot P; Proctor, Deborah D; Regueiro, Miguel D; Rioux, John D; Schumm, Phil; Taylor, Kent D; Silverberg, Mark S; Steinhart, A Hillary; Hernaez, Ruben; Lazarev, Mark

2017-08-01

Early appendectomy is inversely associated with the development of UC. However, the impact of appendectomy on the clinical course of UC is controversial, generally favouring a milder disease course. We aim to describe the effect appendectomy has on the disease course of UC with focus on the timing of appendectomy in relation to UC diagnosis. Using the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium database of patients with UC, the risk of colectomy was compared between patients who did and did not undergo appendectomy. In addition, we performed a meta-analysis of studies that examined the association between appendectomy and colectomy. 2980 patients with UC were initially included. 111 (4.4%) patients with UC had an appendectomy; of which 63 were performed prior to UC diagnosis and 48 after diagnosis. In multivariable analysis, appendectomy performed at any time was an independent risk factor for colectomy (OR 1.9, 95% CI 1.1 to 3.1), with appendectomy performed after UC diagnosis most strongly associated with colectomy (OR 2.2, 95% CI 1.1 to 4.5). An updated meta-analysis showed appendectomy performed either prior to or after UC diagnosis had no effect on colectomy rates. Appendectomy performed at any time in relation to UC diagnosis was not associated with a decrease in severity of disease. In fact, appendectomy after UC diagnosis may be associated with a higher risk of colectomy. These findings question the proposed use of appendectomy as treatment for UC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

UCS-PROMOVE: The Engineer of the Future

ERIC Educational Resources Information Center

Villas-Boas, V.

2010-01-01

The Universidade de Caxias do Sul (UCS) elaborated the cooperative project called "The engineer of the future", with the objective of promoting science and engineering among high school teachers and students. This project aims to improve the quality of the teaching and to increase the interest of students in technological areas, leading…

Davies the Manipulator of "The Salterton Trilogy."

ERIC Educational Resources Information Center

Tedford, Barbara W.

Some critics of Robertson Davies' three novels that comprise the Salterton trilogy, "Tempest-Tost" (1951), "Leaven of Malice" (1954), and "A Mixture of Frailties" (1958) complain of their creaky novelistic machinery, suggesting that they merely show an essayist, or journalist, becoming a novelist. These three novels,…

Oxidation of UC: An in situ high temperature environmental scanning electron microscopy study

NASA Astrophysics Data System (ADS)

Gasparrini, Claudia; Podor, Renaud; Horlait, Denis; Rushton, Michael J. D.; Fiquet, Olivier; Lee, William Edward

2017-10-01

In situ HT-ESEM oxidation of sintered UC fragments revealed the morphological changes occurring during the transformation between UC to UO2 and UO2 to U3O8 at 723-848 K and in an atmosphere of 10-100 Pa O2. Two main oxidation pathways were revealed. Oxidation at 723 K in atmospheres ≤25 Pa O2 showed the transformation from UC to UO2+x, as confirmed by post mortem HRTEM analysis. This oxidation pathway was comprised of three steps: (i) an induction period, where only surface UC particles oxidised, (ii) a sample area expansion accompanied by crack formation and propagation, (iii) a stabilisation of the total crack length inferring that crack propagation had stopped. Samples oxidised under 50 Pa O2 at 723 K and at 773-848 K for 10-100 Pa O2 showed an "explosive" oxidation pathway: (i) sample area expansion occurred as soon as oxygen was inserted into the chamber and crack propagation and crack length followed an exponential law; (ii) cracks propagated as a network and the oxide layer fragmented, (iii) an "explosion" occurred causing a popcorn-like transformation, typical for oxidation from UO2 to U3O8. HRTEM characterisation revealed U3O8 preferentially grow in the [001] direction. The explosive growth, triggered by ignition of UC, proceeded as a self-propagating high-temperature synthesis reaction, with a propagation speed of 150-500 ± 50 μm/s.

A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis

PubMed Central

Chen, Lijian; Liu, Meiling; Zhang, Nan; Zhang, Li; Luo, Yuanwei; Liu, Zhenzhong; Dai, Lijun; Jiang, Yiguo

2016-01-01

As a common toxic metal, lead has significant neurotoxicity to brain development. Long non-coding RNAs (lncRNAs) function in multiple biological processes. However, whether lncRNAs are involved in lead-induced neurotoxicity remains unclear. Uc.173 is a lncRNA from a transcribed ultra-conservative region (T-UCR) of human, mouse and rat genomes. We established a lead-induced nerve injury mouse model. It showed the levels of Uc.173 decreased significantly in hippocampus tissue and serum of the model. We further tested the expression of Uc.173 in serum of lead-exposed children, which also showed a tendency to decrease. To explore the effects of Uc.173 on lead-induced nerve injury, we overexpressed Uc.173 in an N2a mouse nerve cell line and found Uc.173 had an inhibitory effect on lead-induced apoptosis of N2a. To investigate the molecular mechanisms of Uc.173 in apoptosis associated with lead-induced nerve injury, we predicted the target microRNAs of Uc.173 by using miRanda, TargetScan and RegRNA. After performing quantitative real-time PCR and bioinformatics analysis, we showed Uc.173 might inter-regulate with miR-291a-3p in lead-induced apoptosis and regulate apoptosis-associated genes. Our study suggests Uc.173 significantly inhibits the apoptosis of nerve cells, which may be mediated by inter-regulation with miRNAs in lead-induced nerve injury. PMID:26683706

75 FR 38147 - FirstEnergy Nuclear Operating Company; Davis-Besse Nuclear Power Station; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-346; NRC-2010-0240] FirstEnergy Nuclear Operating Company; Davis-Besse Nuclear Power Station; Exemption 1.0 Background FirstEnergy Nuclear Operating Company... of the Davis-Besse Nuclear Power Station, Unit 1 (DBNPS). The license provides, among other things...

75 FR 80549 - FirstEnergy Nuclear Operating Company, Davis-Besse Nuclear Power Station; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-346; NRC-2010-0378] FirstEnergy Nuclear Operating Company, Davis-Besse Nuclear Power Station; Exemption 1.0 Background FirstEnergy Nuclear Operating Company... of the Davis-Besse Nuclear Power Station, Unit 1 (DBNPS). The license provides, among other things...

Rise Time of the Simulated VERITAS 12 m Davies-Cotton Reflector

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Richard J.

The Very Energetic Radiation Imaging Telescope Array System (VERITAS) will utilise Imaging Atmospheric Cherenkov Telescopes (IACTs) based on a Davies-Cotton design with f-number f/1.0 to detect cosmic gamma-rays. Unlike a parabolic reflector, light from the Davies-Cotton does not arrive isochronously at the camera. Here the effect of the telescope geometry on signal rise-time is examined. An almost square-pulse arrival time profile with a rise time of 1.7 ns is found analytically and confirmed through simulation.

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease.

PubMed

Wang, Xinxin; Ma, Shanshan; Yang, Bo; Huang, Tuanjie; Meng, Nan; Xu, Ling; Xing, Qu; Zhang, Yanting; Zhang, Kun; Li, Qinghua; Zhang, Tao; Wu, Junwei; Yang, Greta Luyuan; Guan, Fangxia; Wang, Jian

2018-02-26

Mesenchymal stem cell transplantation is a promising therapeutic approach for Alzheimer's disease (AD). However, poor engraftment and limited survival rates are major obstacles for its clinical application. Resveratrol, an activator of silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is beneficial for neurodegenerative disorders. The present study is designed to explore whether resveratrol regulates the fate of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol would be efficacious in the treatment of neurodegeneration in a mouse model of AD through SIRT1 signaling. Herein, we report that resveratrol facilitates hUC-MSCs engraftment in the hippocampus of AD mice and resveratrol enhances the therapeutic effects of hUC-MSCs in this model as demonstrated by improved learning and memory in the Morris water maze, enhanced neurogenesis and alleviated neural apoptosis in the hippocampus of the AD mice. Moreover, hUC-MSCs and resveratrol jointly regulate expression of hippocampal SIRT1, PCNA, p53, ac-p53, p21, and p16. These data strongly suggests that hUC-MSCs transplantation combined with resveratrol may be an effective therapy for AD. Copyright © 2017. Published by Elsevier B.V.

Cloud streets in Davis Strait

NASA Image and Video Library

2017-12-08

The late winter sun shone brightly on a stunning scene of clouds and ice in the Davis Strait in late February, 2013. The Moderate Resolution Imaging Spectroradiometer aboard NASA’s Aqua satellite captured this true-color image on February 22 at 1625 UTC. The Davis Strait connects the Labrador Sea (part of the Atlantic Ocean) in the south with Baffin Bay to the north, and separates Canada, to the west, from Greenland to the east. Strong, steady winds frequently blow southward from the colder Baffin Bay to the warmer waters of the Labrador Sea. Over ice, the air is dry and no clouds form. However, as the Arctic air moves over the warmer, open water the rising moist air and the temperature differential gives rise to lines of clouds. In this image, the clouds are aligned in a beautiful, parallel pattern. Known as “cloud streets”, this pattern is formed in a low-level wind, with the clouds aligning in the direction of the wind. Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

UCS-PROMOVE: The engineer of the future

NASA Astrophysics Data System (ADS)

Villas-Boas, V.

2010-06-01

The Universidade de Caxias do Sul (UCS) elaborated the cooperative project called 'The engineer of the future', with the objective of promoting science and engineering among high school teachers and students. This project aims to improve the quality of the teaching and to increase the interest of students in technological areas, leading to a future career in engineering. The activities of this project were planned to give meaning and foundation to the teaching-learning process of science and for the application of theory in the solution of real problems, while articulating scientific, economic, environmental, social and political aspects and also to reinforce the important role of engineering in society. Amongst the activities to be offered to high school teachers and students are a specialisation course for teachers based upon new educational methodologies, workshops in different areas of science and technology, a programme entitled 'Encouraging girls in technology, science and engineering', science fairs and visits to the industries of the region. Activities with the engineering instructors of UCS are also being developed in order to help them to incorporate in their classes more effective pedagogical strategies for educating the engineer-to-be.

Davies Critical Point and Tunneling

NASA Astrophysics Data System (ADS)

La, Hoseong

2012-04-01

From the point of view of tunneling, the physical meaning of the Davies critical point of a second-order phase transition in the black hole thermodynamics is clarified. At the critical point, the nonthermal contribution vanishes so that the black hole radiation is entirely thermal. It separates two phases: one with radiation enhanced by the nonthermal contribution, the other suppressed by the nonthermal contribution. We show this in both charged and rotating black holes. The phase transition is also analyzed in the cases in which emissions of charges and angular momenta are incorporated.

Characterization of Vegetation using the UC Davis Remote Sensing Testbed

NASA Astrophysics Data System (ADS)

Falk, M.; Hart, Q. J.; Bowen, K. S.; Ustin, S. L.

2006-12-01

Remote sensing provides information about the dynamics of the terrestrial biosphere with continuous spatial and temporal coverage on many different scales. We present the design and construction of a suite of instrument modules and network infrastructure with size, weight and power constraints suitable for small scale vehicles, anticipating vigorous growth in unmanned aerial vehicles (UAV) and other mobile platforms. Our approach provides the rapid deployment and low cost acquisition of high aerial imagery for applications requiring high spatial resolution and revisits. The testbed supports a wide range of applications, encourages remote sensing solutions in new disciplines and demonstrates the complete range of engineering knowledge required for the successful deployment of remote sensing instruments. The initial testbed is deployed on a Sig Kadet Senior remote controlled plane. It includes an onboard computer with wireless radio, GPS, inertia measurement unit, 3-axis electronic compass and digital cameras. The onboard camera is either a RGB digital camera or a modified digital camera with red and NIR channels. Cameras were calibrated using selective light sources, an integrating spheres and a spectrometer, allowing for the computation of vegetation indices such as the NDVI. Field tests to date have investigated technical challenges in wireless communication bandwidth limits, automated image geolocation, and user interfaces; as well as image applications such as environmental landscape mapping focusing on Sudden Oak Death and invasive species detection, studies on the impact of bird colonies on tree canopies, and precision agriculture.

Vegetative communities, Davis and Lavender Canyons, Paradox Basin, Utah: ecosystem studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-04-01

The major vegetative communities of Davis and Lavender canyons located in southeastern Utah are characterized. The report identifies potential secondary impacts and appropriate mitigation options. The Davis Canyon and Lavender Canyon Study Area contains nine major vegetative communities: galleta-shadscale, juniper-blackbrush, juniper-shadscale-ephedra, shadscale-ephedra, grayia-shadscale, juniper, drywash, greasewood, and riparian. The natural recovery times of these communities are exceedingly long. Natural reinvasion of various species would take from 15 to 100 years. No threatened or endangered plant species were identified in the study area. Davis and Lavender canyons have been subject to off-road vehicle activity and extensive grazing. The plant communities maymore » be subject to additional impacts as a result of increased human activity and off-highway activities such as camping, hiking, and hunting could result in changes in cover, composition, and frequency of plant species. Mitigation options for potential impacts include shuttle-busing workers to the site from the highway and fencing site access roads to prevent vehicles from leaving the roads.« less

Recent trends and future directions for the medical treatment of ulcerative colitis.

PubMed

Naganuma, Makoto; Mizuno, Shinta; Nanki, Kosaku; Sugimoto, Shinya; Kanai, Takanori

2016-12-01

Recently, several medical treatments for ulcerative colitis (UC) have been developed, including 5-aminosalicylic acids (5-ASAs), corticosteroids, thiopurine, calcineurin inhibitors, and anti-tumor necrosis factor (TNF) α treatments. Treatment options including calcineurin inhibitors and anti-TNF treatment for refractory UC are discussed in this article. Furthermore, upcoming treatments are introduced, such as golimumab, vedolizumab, AJM300, tofacitinib. Budesonide foamwill be used as one treatment option in patients with distal colitis. Herbal medicine, such as Qing-Dai is also effective for active UC and may be useful for patients who are refractory to anti-TNFα treatments. In the near future, physicians will able to use many different treatments for UC patients. However, we should not forget 5-ASA and corticosteroids as the fundamental treatments for UC patients.

77 FR 16548 - Florida Petroleum Reprocessors Superfund Site; Davie, Broward County, FL; Notice of Settlements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

...-2012- 3766; CERCLA-04-2012-3765] Florida Petroleum Reprocessors Superfund Site; Davie, Broward County... costs concerning the Florida Petroleum Reprocessors Superfund Site located in Davie, Broward County.... Painter. Submit your comments by Site name Florida Petroleum Reprocessors by one of the following methods...

Quantification of process variables for carbothermic synthesis of UC 1-xN x fuel microspheres

DOE PAGES

Lindemer, Terrance B.; Silva, Chinthaka M.; Henry, Jr, John James; ...

2016-11-05

This report details the continued investigation of process variables involved in converting sol-gel-derived, urania-carbon microspheres to ~820-μm-dia. UC 1-xN x fuel kernels in flow-through, vertical Mo and W crucibles at temperatures up to 2123 K. Experiments included calcining of air-dried UO 3-H 2O-C microspheres in Ar and H 2-containing gases, conversion of the resulting UO 2-C kernels to dense UO2:2UC in the same gases and vacuum, and its conversion in N 2 to UC 1-xN x (x = ~0.85). The thermodynamics of the relevant reactions were applied extensively to interpret and control the process variables. Producing the precursor UO 2:2UCmore » kernel of ~96% theoretical density was required, but its subsequent conversion to UC 1-xN x at 2123 K was not accompanied by sintering and resulted in ~83-86% of theoretical density. Increasing the UC 1-xN x kernel nitride component to ~0.98 in flowing N 2-H 2 mixtures to evolve HCN was shown to be quantitatively consistent with present and past experiments and the only useful application of H 2 in the entire process.« less

33 CFR 165.T13-175 - Safety Zone; M/V DAVY CROCKETT, Columbia River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone; M/V DAVY CROCKETT....T13-175 Safety Zone; M/V DAVY CROCKETT, Columbia River. (a) Location: The following area is a safety zone: (1) All waters of the Columbia River encompassed within the following four points: point one at...

STS-47 MS Davis dons LES with technicians' help prior to JSC bailout training

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, Mission Specialist (MS) N. Jan Davis, wearing a launch and entry suit (LES), looks on as technicians adjust her LES parachute pack prior to launch emergency egress (bailout) exercises in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9A. Davis is making her first flight in space.

New Leaders for Troubled Schools: Jacquelyn Davis Works with D.C.'s Education Bureaucracy

ERIC Educational Resources Information Center

Currie, Tyler

2007-01-01

In this article the author presents Jacquelyn Davis, the executive director of the Washington office of New Leaders for New Schools (NLNS), a nonprofit dedicated to training recruits drawn from a range of sectors for leadership in failing school systems. Davis is overseeing a rapidly expanding crop of new principals who are promising to revitalize…

DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC).

PubMed

Arasaradnam, Ramesh P; Khoo, Kevin; Bradburn, Mike; Mathers, John C; Kelly, Seamus B

2010-07-01

Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and no studies exist that assess its relationship with lifestyle exposures. The methylation level of both ESR-1 and N-33 genes were significantly higher in UC subjects compared with controls (7.9% vs. 5.9%; p = 0.015 and 66% vs. 9.3%; p < 0.001 respectively). There was no detectable difference in global DNA methylation between patients with UC and age and sex matched controls. No associations between indices of DNA methylation and anthropometric measures or smoking patterns were detected. To assess genomic methylation and promoter methylation of the ESR-1 (oestrogen receptor-1) and N-33 (tumor suppressor candidate-3) genes in the macroscopically normal mucosa of UC patients as well as to investigate effects of anthropometric and lifestyle exposures on DNA methylation. Sixty eight subjects were recruited (24 UC and 44 age and sex matched controls). Colorectal mucosal biopsies were obtained and DNA was extracted. Genomic DNA methylation was quantified using the tritium-labelled cytosine extension assay (3[H] dCTP) while gene specific methylation was quantified using the COBRA method. For the first time, we have shown increased methylation in the promoter regions of the putative tumor suppressor gene N-33 in macroscopically normal mucosa of patients with UC. In addition, we have confirmed that methylation of ESR-1 promoter is higher in UC patients compared with age and sex matched controls. These findings suggest that inactivation through methylation of the putative tumor suppressor genes N-33 and ESR-1 may not be associated with colorectal carcinogenesis in UC.

76 FR 76438 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Davis-Bacon...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-07

... for OMB Review; Comment Request; Davis-Bacon Certified Payroll ACTION: Notice. SUMMARY: The Department... request (ICR) titled, ``Davis-Bacon Certified Payroll,'' to the Office of Management and Budget (OMB) for... payrolls to the Federal agency contracting for or financing the construction project, if the agency is a...

Draft environmental assessment: Davis Canyon site, Utah. Nuclear Waste Policy Act (Section 112). [Contains glossary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1984-12-01

In February 1983, the US Department of Energy (DOE) identified the Davis Canyon site in Utah, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Davis Canyon site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment (EA), which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluationsmore » are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Davis Canyon site is not disqualified under the guidelines. The site is in the Paradox Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Lavender Canyon site. Although the Lavender Canyon site appears to be suitable for site characterization, the DOE has concluded that the Davis Canyon site is the preferred site in the Paradox Basin. Furthermore, the DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Davis Canyon site as one of five sites suitable for characterization. Having compared the Davis Canyon site with the other four sites proposed for nomination, the DOE has determined that the Davis Canyon site is not one of the three preferred sites for recommendation to the President as candidates for characterization.« less

A critical comparison of Davis' Principles of Plastic Surgery with Gillies' Plastic Surgery of the face.

PubMed

Freshwater, M Felix

2011-01-01

The second decade of the 20th century saw the publication of two landmark books - John Staige Davis' Plastic Surgery its Principles and Practice published in Philadelphia in 1919 and Major Harold Gillies' Plastic Surgery of the Face published in the United Kingdom early 1920. The aim of this paper is to compare the books critically as scholarly achievements in their time and note their present day relevance. Copies of both books are available online having been scanned by Google and Microsoft. They were analyzed with Acrobat software for key words. A senior plastic surgeon with over 30 years of clinical experience reviewed both books for current relevance. Davis' book was more comprehensive as it encompassed reconstructive plastic surgery from head to toe while Gillies' book focused on the face. Davis' book contained a bibliography over 2000 references, while Gillies' book had one reference. Despite Davis's title containing the word 'Principles', Gillies' book not only mentioned principles almost five times as often, but almost all of Gillies' principles remain relevant 90 years later. Furthermore, the quality of Gillies' post-operative results are far outshines to Davis'. While Davis' book demonstrates his honesty and scholarship, now it is as interesting as a historical curiosity. Gillies' book remains valuable as it shows his originality and the continued relevance of his principles. Copyright © 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

The UC2-x - Carbon eutectic: A laser heating study

NASA Astrophysics Data System (ADS)

Manara, D.; Boboridis, K.; Morel, S.; De Bruycker, F.

2015-11-01

The UC2-x - carbon eutectic has been studied by laser heating and fast multi-wavelength pyrometry under inert atmosphere. The study has been carried out on three compositions, two of which close to the phase boundary of the UC2-x - C miscibility gap (with C/U atomic ratios 2 and 2.1), and one, more crucial, with a large excess of carbon (C/U = 2.82). The first two compositions were synthesised by arc-melting. This synthesis method could not be applied to the last composition, which was therefore completed directly by laser irradiation. The U - C - O composition of the samples was checked by using a combustion method in an ELTRA® analyser. The eutectic temperature, established to be 2737 K ± 20 K, was used as a radiance reference together with the cubic - tetragonal (α → β) solid state transition, fixed at 2050 K ± 20 K. The normal spectral emissivity of the carbon-richer compounds increases up to 0.7, whereas the value 0.53 was established for pure hypostoichiometric uranium dicarbide at the limit of the eutectic region. This increase is analysed in the light of the demixing of excess carbon, and used for the determination of the liquidus temperature (3220 K ± 50 K for UC2.82). Due to fast solid state diffusion, also fostered by the cubic - tetragonal transition, no obvious signs of a lamellar eutectic structure could be observed after quenching to room temperature. The eutectic surface C/UC2-x composition could be qualitatively, but consistently, followed during the cooling process with the help of the recorded radiance spectra. Whereas the external liquid surface is almost entirely constituted by uranium dicarbide, it gets rapidly enriched in demixed carbon upon freezing. Demixed carbon seems to quickly migrate towards the inner bulk during further cooling. At the α → β transition, uranium dicarbide covers again the almost entire external surface.

Survey on Views and Knowledge of House Officers on Medical-Legal Issues.

ERIC Educational Resources Information Center

Beninger, Paul R.; And Others

1985-01-01

House medical staff of the University of California, Davis, Medical Center were administered a questionnaire to determine their knowledge of relevant medical-legal principles. Responses from 111 house staff indicated that pediatrics, physical medicine, and rehabilitation staff confronted more medical-legal issues than pathology staff. (SW)

48 CFR 52.222-6 - Davis-Bacon Act.

Code of Federal Regulations, 2012 CFR

2012-10-01

... or nearly so, to the performance of a contract. (b)(1) All laborers and mechanics employed or working... contractual relationship which may be alleged to exist between the Contractor and such laborers and mechanics... fide fringe benefits under section 1(b)(2) of the Davis-Bacon Act on behalf of laborers or mechanics...

48 CFR 52.222-6 - Davis-Bacon Act.

Code of Federal Regulations, 2013 CFR

2013-10-01

... or nearly so, to the performance of a contract. (b)(1) All laborers and mechanics employed or working... contractual relationship which may be alleged to exist between the Contractor and such laborers and mechanics... fide fringe benefits under section 1(b)(2) of the Davis-Bacon Act on behalf of laborers or mechanics...

Application of the Software as a Service Model to the Control of Complex Building Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Donadee, Jonathan; Marnay, Chris

2011-03-17

In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building.more » The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analysed.« less

Application of the Software as a Service Model to the Control of Complex Building Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stadler, Michael; Donadee, Jon; Marnay, Chris

2011-03-18

In an effort to create broad access to its optimization software, Lawrence Berkeley National Laboratory (LBNL), in collaboration with the University of California at Davis (UC Davis) and OSISoft, has recently developed a Software as a Service (SaaS) Model for reducing energy costs, cutting peak power demand, and reducing carbon emissions for multipurpose buildings. UC Davis currently collects and stores energy usage data from buildings on its campus. Researchers at LBNL sought to demonstrate that a SaaS application architecture could be built on top of this data system to optimize the scheduling of electricity and heat delivery in the building.more » The SaaS interface, known as WebOpt, consists of two major parts: a) the investment& planning and b) the operations module, which builds on the investment& planning module. The operational scheduling and load shifting optimization models within the operations module use data from load prediction and electrical grid emissions models to create an optimal operating schedule for the next week, reducing peak electricity consumption while maintaining quality of energy services. LBNL's application also provides facility managers with suggested energy infrastructure investments for achieving their energy cost and emission goals based on historical data collected with OSISoft's system. This paper describes these models as well as the SaaS architecture employed by LBNL researchers to provide asset scheduling services to UC Davis. The peak demand, emissions, and cost implications of the asset operation schedule and investments suggested by this optimization model are analyzed.« less

48 CFR 422.404 - Davis-Bacon Act wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Davis-Bacon Act wage determinations. 422.404 Section 422.404 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts...

Urethral catheters and medical malpractice: a legal database review from 1965 to 2015.

PubMed

Awad, Mohannad A; Osterberg, E Charles; Chang, Helena; Gaither, Thomas W; Alwaal, Amjad; Fox, Ryan; Breyer, Benjamin N

2016-10-01

Urethral catheters (UCs) are commonly used in medicine and are associated with complications such as urinary tract infections (UTIs) and trauma. Given UC complications and their ubiquitous usage in healthcare, there is a potential for liability risk. We aim to explore litigation involving UC-related complications. The LexisNexis legal database was queried for all state and federal cases from January 1965 through October 2015 using the terms "urethral catheter" or "Foley catheter" in combination with "medical malpractice", "negligence", "medical error", and "trauma". Each case was reviewed for reported medical characteristics and legal aspects, including the outcome of the case. Our search yielded 29 cases. Urologists were the most common providers cited as defendants (21%), all of whom were successful in their defense. The most common malpractice claim was for traumatic insertion (48%). Pain was the most common type of damage claimed by plaintiffs (28%), followed by UTI (24%). Nineteen (66%) cases favored defendants, while 10 (34%) cases favored the plaintiffs, of which 2 (7%) were settled out of the court. In settled cases, the mean settlement received by plaintiffs was $55,750 (range, $25,000-$86,500). The mean award to plaintiffs for cases determined by the court was $112,991 (range, $4,000-$325,000). Despite widespread usage of UC over a 50-year period, lawsuits centered on UC misuse are rare at the state and federal court levels. Of litigated cases, urologists are commonly involved yet have successful defenses.

Innovation and dedication underpin management of sudden oak death (Phytophthora ramorum) in California and Oregon forests

Treesearch

Susan J. Frankel

2017-01-01

This special issue of Forest Phytophthoras serves as part of the proceedings from the Sixth Sudden Oak Death Science Symposium held June 21 -23, 2016 at Fort Mason Center in San Francisco, CA, USA. The symposium marked almost 16 years to the day that David Rizzo (UC Davis) and Matteo Garbelotto (UC Berkeley) identified the cause of sudden oak death to be a previously...

Diversity initiatives in academic psychiatry: applying cultural competence.

PubMed

Lim, Russell F; Luo, John S; Suo, Shannon; Hales, Robert E

2008-01-01

This article describes the process of change in an academic department of psychiatry that has led to the development of a diversity initiative in teaching, research, recruitment, and services. The authors performed a literature review of diversity initiatives using PubMed. The authors then wrote a case study of the development of a diversity initiative at UC Davis. Some articles on diversity initiatives were found, but none that detailed the administrative process, funding, or sustainability of such initiatives. In 1999, the UC Davis Department of Psychiatry and Behavioral Sciences recognized the importance of issues of diversity and established the Diversity Advisory Committee, a group of department faculty and residents that explores and addresses the diversity needs of the department. In our observations, there are at least three requirements for a successful diversity initiative: a diverse patient population, a "critical mass" of interested faculty, and support of the administration. With these three factors in place, the Diversity Advisory Committee produced four Continuing Medical Education symposia focused on diversity topics, developed a 4-year cultural psychiatry curriculum and a 4-year religion and spirituality curriculum within the residency, and supported nine residents who received awards from the APA's Minority Fellowships in 8 years. Future plans include department-wide and medical school faculty-wide diversity training, educational research, and a postgraduate fellowship in cultural psychiatry. This article shows that a diversity initiative can be undertaken with interested minority and nonminority faculty, administrative support, and a diverse patient population. The authors hope this article will provide assistance to other academic departments in developing diversity initiatives.

In defense of compilation: A response to Davis' form and content in model-based reasoning

NASA Technical Reports Server (NTRS)

Keller, Richard

1990-01-01

In a recent paper entitled 'Form and Content in Model Based Reasoning', Randy Davis argues that model based reasoning research aimed at compiling task specific rules from underlying device models is mislabeled, misguided, and diversionary. Some of Davis' claims are examined and his basic conclusions are challenged about the value of compilation research to the model based reasoning community. In particular, Davis' claim is refuted that model based reasoning is exempt from the efficiency benefits provided by knowledge compilation techniques. In addition, several misconceptions are clarified about the role of representational form in compilation. It is concluded that techniques have the potential to make a substantial contribution to solving tractability problems in model based reasoning.

Physician Perspectives on Unresolved Issues in the Management of Ulcerative Colitis: The UC Horizons Project.

PubMed

Gisbert, Javier P; Barreiro-de Acosta, Manuel; Esteve, María; García-Sánchez, Valle; Gomollón, Fernando; Guardiola, Jordi; Hinojosa, Joaquin; Martín Arranz, Maria-Dolores; Minguez, Miguel; Taxonera, Carlos; Vera, Isabel

2016-03-01

There is still uncertainty about what constitutes the best therapeutic practice in ulcerative colitis (UC). The purpose of the "UC Horizons Project" was to raise a series of questions regarding the management of UC to provide responses based on the best scientific evidence available. The 11 members of the scientific committee prepared draft answers to the 10 questions from available evidence after a literature search. A total of 48 Spanish gastroenterology specialists nationwide participated in the project. The national meeting discussed the 10 issues in working groups and reached consensus regarding the recommendations by anonymous, interactive vote following the Delphi methodology. Final answers were developed, based on evidence and clinical experience of the participants. All the recommendations achieved a high level of agreement in the plenary vote, although the quality of the evidence was markedly heterogeneous. The lowest percentage of agreement corresponded to the questions with the weakest level of evidence, highlighting the necessity of conducting further studies in these areas. The recommendations focused on (1) aminosalicylates therapy (regarding dose and appropriateness of coadministration with thiopurines), (2) corticosteroid therapy (regarding dose and route of administration), (3) thiopurine treatment (regarding indications and possibility of withdrawal), (4) anti-tumor necrosis factor therapy (regarding appropriateness of combination with thiopurines, intensification, or discontinuation of treatment), and (5) colorectal cancer (regarding risk and time trends). The UC Horizons Project raised a series of eminently practical questions about the management of UC and provided responses based on the best scientific evidence available.

48 CFR 622.404 - Davis-Bacon Act wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Davis-Bacon Act wage determinations. 622.404 Section 622.404 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts Involving...

STS-47 MS Davis holds mixed protein sample while working at SLJ Rack 7 FFEU

NASA Image and Video Library

1992-09-20

STS047-03-024 (12 - 20 Sept 1992) --- Astronaut N. Jan Davis, mission specialist, talks to ground controllers as she works with the Free Flow Electrophoresis Unit (FFEU) in the Science Module of the Earth-orbiting Space Shuttle Endeavour. Davis joined five other NASA astronauts and a Japanese payload specialist for eight days of scientific research onboard Endeavour.

Davis Fire: Fire behavior and fire effects analysis

Treesearch

LaWen T. Hollingsworth

2010-01-01

The Davis Fire presents an interesting example of fire behavior in subalpine fir, partially dead lodgepole pine with multiple age classes, and moist site Douglas-fir vegetation types. This has been summer of moderate temperatures and intermittent moisture that has kept live herbaceous and live woody moistures fairly high and dead fuel moistures at a moderate level....

Long-term sustainability in Davis Late Successional Reserve

Treesearch

Jim Stone; Joan Kittrell

2004-01-01

A pilot watershed analysis along with the Davis Late Successional Reserve analysis in the range of the northern spotted owl identified potential loss of suitable habitat, reduction in the numbers of large trees, and lack of replacements for large trees. A variety of silvicultural thinning techniques has been used to address these important issues and to move toward a...

MF2KtoMF05UC, a Program To Convert MODFLOW-2000 Files to MODFLOW-2005 and UCODE_2005 Files

USGS Publications Warehouse

Harbaugh, Arlen W.

2007-01-01

The program MF2KtoMF05UC has been developed to convert MODFLOW-2000 input files for use by MODFLOW-2005 and UCODE_2005. MF2KtoMF05UC was written in the Fortran 90 computer language. This report documents the use of MF2KtoMF05UC.

Technology Acceptance of Electronic Medical Records by Nurses

ERIC Educational Resources Information Center

Stocker, Gary

2010-01-01

The purpose of this study was to evaluate the Technology Acceptance Model's (TAM) relevance of the intention of nurses to use electronic medical records in acute health care settings. The basic technology acceptance research of Davis (1989) was applied to the specific technology tool of electronic medical records (EMR) in a specific setting…

NIH's National Institute of General Medical Sciences celebrates 45 years of Discovery for Health

MedlinePlus

... Alison Davis NIH's National Institute of General Medical Sciences celebrates 45 years of Discovery for Health The National Institute of General Medical Sciences (NIGMS) is the NIH institute that primarily supports ...

The Davis Junior High Global Warming Project and Bike/Walk to School Challenge

NASA Astrophysics Data System (ADS)

King, A.; Anastasio, C.; Niemeier, D.; Scow, K.

2007-12-01

Junior high school students in Davis, CA, were targeted in an outreach project combining interactive and hands- on information about global warming and carbon footprints with a bike/walk to school challenge. The project was conducted by the Kearney Foundation of Soil Science, the Department of Land, Air and Water Resources and the John Muir Institute of the Environment at the University of California Davis. Approximately 70 undergraduates, graduate students, post-doc researchers, faculty and staff from UCD and the town of Davis were involved. Workshops were held in the 7th, 8th and 9th grade science classes in Davis' 3 junior high schools, reaching a total of 1700 students. Each 50-minute presentation consisted of a Global Warming Jeopardy game, followed by individual calculation of carbon footprints oriented towards a junior high school student. Biking or walking to school, instead commuting by car, was introduced as an important and feasible activity that could reduce one's carbon footprint. Working with staff from each junior high, students were then challenged to increase biking or walking to school during a 2 week Bike/Walk to School Challenge . UCD students and staff monitored automobile commuting (# cars, idle time) and bike use during this time and provided incentives for biking or walking . All schools were recognized for efforts to reduce their carbon footprints, and the concept was reinforced at the start of the following school year by planting a tree at each school.

Report of the Task Force on the Status of Women at the University of California, Davis.

ERIC Educational Resources Information Center

Fisher, Kathleen M.

The charge given to the Task Force on the Status of Women at the University of California, Davis, was to determine the employment opportunities for women on the Davis campus. The Task Force addressed itself primarily to 4 major employment categories: non-academic staff, academic staff, faculty, and administration, with lesser consideration given…

Urethral catheters and medical malpractice: a legal database review from 1965 to 2015

PubMed Central

Osterberg, E. Charles; Chang, Helena; Gaither, Thomas W.; Alwaal, Amjad; Fox, Ryan; Breyer, Benjamin N.

2016-01-01

Background Urethral catheters (UCs) are commonly used in medicine and are associated with complications such as urinary tract infections (UTIs) and trauma. Given UC complications and their ubiquitous usage in healthcare, there is a potential for liability risk. We aim to explore litigation involving UC-related complications. Methods The LexisNexis legal database was queried for all state and federal cases from January 1965 through October 2015 using the terms “urethral catheter” or “Foley catheter” in combination with “medical malpractice”, “negligence”, “medical error”, and “trauma”. Each case was reviewed for reported medical characteristics and legal aspects, including the outcome of the case. Results Our search yielded 29 cases. Urologists were the most common providers cited as defendants (21%), all of whom were successful in their defense. The most common malpractice claim was for traumatic insertion (48%). Pain was the most common type of damage claimed by plaintiffs (28%), followed by UTI (24%). Nineteen (66%) cases favored defendants, while 10 (34%) cases favored the plaintiffs, of which 2 (7%) were settled out of the court. In settled cases, the mean settlement received by plaintiffs was $55,750 (range, $25,000–$86,500). The mean award to plaintiffs for cases determined by the court was $112,991 (range, $4,000–$325,000). Conclusions Despite widespread usage of UC over a 50-year period, lawsuits centered on UC misuse are rare at the state and federal court levels. Of litigated cases, urologists are commonly involved yet have successful defenses. PMID:27785434

Brownfields Davis Bacon for Cleanup Grants: Petroleum for Government Entities

EPA Pesticide Factsheets

Terms & conditions specify how Recipients will assist EPA in meeting its Davis Bacon responsibilities when DB applies to EPA awards of financial assistance under the Recovery Act or any other statute which makes DB applicable to EPA financial assistance.

Environmental Profiles of Paper vs. Electronic UC-CEAS Annual Reports

EPA Science Inventory

In 2010, the University of Cincinnati College of Engineering and Applied Sciences (UC-CEAS) created a new electronic format for the Annual Report that could be distributed through the college’s website to replace the prior print version. In order to determine the environmental co...

The Davis Social Environment. A Report of Student Opinions.

ERIC Educational Resources Information Center

Low, Jane M.

The perceptions of undergraduates regarding the social environment of the University of California-Davis campus are presented, based on a student opinion survey. The extent and nature of social integration among undergraduates is discussed, with a focus on whether the social environment differs among ethnic groups (Black, Chicano, Asian, and…

Raymond Davis Jr., Solar Neutrinos, and the Solar Neutrino Problems

Science.gov Websites

Neutrinos. II. Experimental; DOE Technical Report, March 16, 1964 Search for Neutrinos from the Sun; DOE Raymond Davis Dies, BNL Newsroom, June 1, 2006 Top Some links on this page may take you to non-federal

Medical Therapy of Active Ulcerative Colitis

PubMed Central

Bürger, Martin; Schmidt, Carsten; Teich, Niels; Stallmach, Andreas

2015-01-01

Summary Background Medical therapy of mild and moderate ulcerative colitis (UC) of any extent is evidence-based and standardized by national and international guidelines. However, patients with steroid-refractory UC still represent a challenge. Methods A literature search using PubMed (search terms: ulcerative colitis, therapy, new, 1-2008-2015) resulted in 821 publications. For the current article, 88 citations were extracted including 36 randomized controlled studies, 18 reviews, and 8 meta-analyses. Results In steroid-refractory UC, early intensive therapy using anti-tumor necrosis factor (TNF) antibodies or the calcineurin inhibitors cyclosporine and tacrolimus is indicated in any case to prevent progression to a toxic megacolon and/or to avoid proctocolectomy. In patients with chronic disease activity, treatment with anti-TNF antibodies has a higher level of evidence than azathioprine therapy and should therefore be preferred. However, there is a subgroup of UC patients who may achieve prolonged steroid-free remission on azathioprine monotherapy. The importance of vedolizumab, a newly registered inhibiting antibody against integrin, has not yet been fully clarified since direct comparison studies are lacking, in particular in relation to anti-TNF antibodies. Conclusion There is a great need for additional innovative therapies, especially in cases of primary non-response or secondary loss of response to anti-TNF antibodies. New small molecules (Janus kinase inhibitors) are promising with an acceptable safety profile and efficacy in UC. Further, strategies that target the intestinal microbiome are currently considered for patients with active or relapsing UC, and may in the future open up new therapeutic options. PMID:26557831

Cusp-Gun Sixth-Harmonic Slotted Gyrotron

NASA Astrophysics Data System (ADS)

Stutzman, R. C.; McDermott, D. B.; Hirata Luhmann, Y., Jr.; Gallagher, D. A.; Spencer, T. A.

2000-10-01

A high-harmonic slotted gyrotron has been constructed at UC Davis to be driven by a 70 kV, 3.5 A, axis-encircling electron beam from a Northrop Grumman Cusp gun. The 94 GHz, slotted sixth-harmonic gyrotron is predicted to generate 50 kW with an efficiency of 20%. Using the profile of the adiabatic field reversal from the UC Davis superconducting test-magnet, EGUN simulations predict that an axis-encircling electron beam will be generated with an axial velocity spread of Δ v_z/v_z=10% for the desired velocity ratio of α =v_z/v_z=1.5. The design will also be presented for an 8th-harmonic W-band gyrotron whose magnetic field can be supplied by a lightweight permanent magnet.

JAFCO d/b/a Paul Davis Restoration and Remodeling Information Sheet

EPA Pesticide Factsheets

JAFCO d/b/a Paul Davis Restoration and Remodeling (the Company) is located in Memphis, Tennessee. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Memphis, Tennessee.

Antarctic meteor observations using the Davis MST and meteor radars

NASA Astrophysics Data System (ADS)

Holdsworth, David A.; Murphy, Damian J.; Reid, Iain M.; Morris, Ray J.

2008-07-01

This paper presents the meteor observations obtained using two radars installed at Davis (68.6°S, 78.0°E), Antarctica. The Davis MST radar was installed primarily for observation of polar mesosphere summer echoes, with additional transmit and receive antennas installed to allow all-sky interferometric meteor radar observations. The Davis meteor radar performs dedicated all-sky interferometric meteor radar observations. The annual count rate variation for both radars peaks in mid-summer and minimizes in early Spring. The height distribution shows significant annual variation, with minimum (maximum) peak heights and maximum (minimum) height widths in early Spring (mid-summer). Although the meteor radar count rate and height distribution variations are consistent with a similar frequency meteor radar operating at Andenes (69.3°N), the peak heights show a much larger variation than at Andenes, while the count rate maximum-to-minimum ratios show a much smaller variation. Investigation of the effects of the temporal sampling parameters suggests that these differences are consistent with the different temporal sampling strategies used by the Davis and Andenes meteor radars. The new radiant mapping procedure of [Jones, J., Jones, W., Meteor radiant activity mapping using single-station radar observations, Mon. Not. R. Astron. Soc., 367(3), 1050-1056, doi: 10.1111/j.1365-2966.2006.10025.x, 2006] is investigated. The technique is used to detect the Southern delta-Aquarid meteor shower, and a previously unknown weak shower. Meteoroid speeds obtained using the Fresnel transform are presented. The diurnal, annual, and height variation of meteoroid speeds are presented, with the results found to be consistent with those obtained using specular meteor radars. Meteoroid speed estimates for echoes identified as Southern delta-Aquarid and Sextantid meteor candidates show good agreement with the theoretical pre-atmospheric speeds of these showers (41 km s -1 and 32 km s -1

10. Detail of map showing Battery Davis and Panama Gun ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Detail of map showing Battery Davis and Panama Gun Mounts at right, by U.S. Engineering Office, San Francisco, California, August 5, 1934. - Fort Funston, Panama Mounts for 155mm Guns, Skyline Boulevard & Great Highway, San Francisco, San Francisco County, CA

Alternative Fuels Data Center: UC Davis Pioneers Research for Plug-In

Science.gov Websites

gas vehicle District of Columbia's Government Fleet Uses a Wide Variety of Alternative Fuels Dec. 5 . Maryland County Fleet Uses Wide Variety of Alternative Fuels Jan. 17, 2015 Photo of a school bus Diego Feb. 2, 2013 Photo of neighborhood electric vehicle Mammoth Cave National Park Uses Only

Identification of hyper-extended crust east of Davie Ridge in the Mozambique Channel

NASA Astrophysics Data System (ADS)

Klimke, Jennifer; Franke, Dieter

2015-04-01

Davie Ridge is a ~1200 km wide, N-S trending bathymetrical high in the Mozambique Channel. Today, it is widely accepted that Davie Ridge is located along a fossil transform fault that was active during the Middle Jurassic and Early Cretaceous (~165-120 Ma). This transform fault results from the breakup of Gondwana, when Madagascar (together with India and Antarctica) drifted from its northerly position in the Gondwana Supercontinent (adjacent to the coasts of Tanzania, Somalia and Kenya) to its present position (e.g. Coffin and Rabinowitz, 1987; Rabinowitz et al., 1983; Segoufin and Patriat, 1980). The southward motion of Madagascar relative to Africa is constrained by the interpretation of magnetic anomalies in the Western Somali Basin, located north of Madagascar (e.g. Rabinowitz et al., 1983). According to Bird (2001), sheared margins share typical characteristics and a common evolution: 1. The transition from continental to oceanic crust is relatively abrupt (~ 50-80 km). 2. Along the continental side of the margin, complex rift basins form that display a wide range of faults. 3. Prominent marginal ridges form along the sheared margin that probably originate from the propagation of the oceanic spreading center along the plate boundary (Bird, 2001). In February and March 2014, a dense geophysical dataset (multichannel seismic, magnetics, gravimetry and bathymetry) with a total of 4300 profile km along the sheared margin was acquired with the R/V Sonne by the Federal Institute for Geosciences and Natural Resources (BGR). A special objective of the project, amongst others, is the characterization and interpretation of the continent-ocean transition seaward of Davie Ridge in the Mozambique Channel. Seismic profiles located east of Davie Ridge in the Western Somali Basin reveal a wide sequence of half-grabens bounded by listric normal faults. We tentatively suggest that this crust is of continental origin and results from rifting between Africa and Madagascar during

STS-47 MS Davis holds mixed protein sample while working at SLJ Rack 7 FFEU

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Mission Specialist (MS) N. Jan Davis labels sample vial containing mixed proteins while conducting the Separation of Biogenic Materials by Electrophoresis Under Zero Gravity / Separation of Animal Cells and Cellular Organella by Means of Free Flow Electrophoresis (FFEU). Davis is in the Spacelab Japan (SLJ) science module aboard Endeavour, Orbiter Vehicle (OV) 105. She talks to ground controllers as she works with the Free Flow Electrophoresis Unit (FFEU) located in SLJ Rack 7.

Arctic Outflow West of Greenland: Mass and Freshwater Fluxes at Davis Strait

NASA Astrophysics Data System (ADS)

Lee, Craig; Curry, Beth; Petrie, Brian; Azetsu-Scott, Kumiko; Gobat, Jason

2014-05-01

Eberhard Fahrbach worked to understand the communication between the Arctic and subpolar oceans and its role in modulating Arctic change. This included long-standing leadership in the Arctic-Subarctic Ocean Flux program and the long-term quantification of fluxes east of Greenland, through Fram Strait, the primary pathway for Atlantic water passing into the Arctic and one of two gateways for freshwater flowing out. Freshwater also exits the Arctic west of Greenland, though the Canadian Arctic Archipelago and, to the south, Davis Strait. The strait provides a convenient choke point for monitoring temporal and spatial variability of Arctic outflow while also characterizing a critical upstream boundary condition for Labrador Sea convection. Fluxes through the Strait represent the net integrated Canadian Archipelago throughflow, over 50% of the Arctic's liquid freshwater discharge, modified by terrestrial inputs and oceanic processes during its southward transit through Baffin Bay. By the time they reach Davis Strait, Arctic waters already embody most of the transformations they undergo prior to exerting their influence on the deepwater formation sites in the Labrador Sea. An ongoing program has characterized Davis Strait volume, freshwater and heat flux since September 2004. Measurements include continuous velocity, temperature and salinity time series collected by a moored array, autumn ship-based hydrographic sections and high-resolution sections occupied by autonomous gliders. Moored instrumentation includes novel new instruments that provide temperature and salinity measurements in the critical region neat the ice-ocean interface and measurements over the shallow Baffin and West Greenland shelves, while gliders have captured the first high-resolution wintertime sections across the Strait. These data show large interannual variability in volume and freshwater transport, with no clear trends observed between 2004-2010. Average volume, liquid freshwater and sea ice

Late-time structure of the Bunch-Davies de Sitter wavefunction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anninos, Dionysios; Anous, Tarek; Freedman, Daniel Z.

2015-11-30

We examine the late time behavior of the Bunch-Davies wavefunction for interacting light fields in a de Sitter background. We use perturbative techniques developed in the framework of AdS/CFT, and analytically continue to compute tree and loop level contributions to the Bunch-Davies wavefunction. We consider self-interacting scalars of general mass, but focus especially on the massless and conformally coupled cases. We show that certain contributions grow logarithmically in conformal time both at tree and loop level. We also consider gauge fields and gravitons. The four-dimensional Fefferman-Graham expansion of classical asymptotically de Sitter solutions is used to show that the wavefunctionmore » contains no logarithmic growth in the pure graviton sector at tree level. Finally, assuming a holographic relation between the wavefunction and the partition function of a conformal field theory, we interpret the logarithmic growths in the language of conformal field theory.« less

Basement control of alkalic flood rhyolite magmatism of the Davis Mountains volcanic field, Trans-Pecos Texas, U.S.A.

NASA Astrophysics Data System (ADS)

Parker, Don F.; White, John C.; Ren, Minghua; Barnes, Melanie

2017-11-01

Voluminous silicic lava flows, erupted 37.4 Ma from widespread centers within the Davis Mountains Volcanic Field (DMVF), covered approximately 10,000 km2 with an initial volume as great as 1000 km3. Lava flows form three major stratigraphic units: the Star Mountain Rhyolite (minimum 220 km3) of the eastern Davis Mountains and adjacent Barilla Mountains, the Crossen Formation ( 75 km3) of the southern Davis Mountains, and the Bracks Rhyolite ( 75 km3) of the Rim Rock region west of the Davis Mountains proper. Similar extensive rhyolite lava also occurs in slightly younger units (Adobe Canyon Rhyolite, 125 km3, 37.1 Ma), Sheep Pasture Formation ( 125 km3, 36 Ma) and, less voluminously, in the Paisano central volcano ( 36.9 Ma) and younger units in the Davis Mountains. Individual lava flows from these units formed fields as extensive as 55 km and 300-m-thick. Flood rhyolite lavas of the Davis Mountains are marginally peralkaline quartz trachyte to low-silica rhyolite. Phenocrysts include alkali feldspar, clinopyroxene, FeTi oxides, and apatite, and, rarely, fayalite, as well as zircon in less peralkaline units. Many Star Mountain flows may be assigned to one of four geochemical groupings. Temperatures were moderately high, ranging from 911 to 860 °C in quartz trachyte and low silica rhyolite. We suggest that flood rhyolite magma evolved from trachyte magma by filter pressing processes, and trachyte from mafic magma in deeper seated plutons. The Davis Mountains segment of Trans-Pecos Texas overlies Grenville basement and is separated from the older Southern Granite and Rhyolite Province to the north by the Grenville Front, and from the younger Coahuila terrane to the south by the Ouachita Front. We suggest that basement structure strongly influenced the timing and nature of Trans-Pecos magmatism, probably in varying degrees of impeding the ascent of mantle-derived mafic magmas, which were produced by upwelling of asthenospheric mantle above the foundered Farallon slab

Brownfields Davis Bacon for Cleanup Grants: Hazardous Substances for Government Entities

EPA Pesticide Factsheets

The following terms and conditions specify how Recipients will assist EPA in meeting its Davis-Bacon (DB) responsibilities when DB applies to EPA awards of financial assistance under any statute which makes DB applicable to EPA financial assistance.

World Federation for Medical Education Policy on international recognition of medical schools' programme.

PubMed

Karle, Hans

2008-12-01

The increasing globalisation of medicine, as manifested in the migration rate of medical doctors and in the growth of cross-border education providers, has inflicted a wave of quality assurance efforts in medical education, and underlined the need for definition of standards and for introduction of effective and transparent accreditation systems. In 2004, reflecting the importance of the interface between medical education and the healthcare delivery sector, a World Health Organization (WHO)/World Federation for Medical Education (WFME) Strategic Partnership to improve medical education was formed. In 2005, the partnership published Guidelines for Accreditation of Basic Medical Education. The WHO/WFME Guidelines recommend the establishment of proper accreditation systems that are effective, independent, transparent and based on medical education-specific criteria. An important prerequisite for this development was the WFME Global Standards programme, initiated in 1997 and widely endorsed. The standards are now being used in all 6 WHO/WFME regions as a basis for quality improvement of medical education throughout its continuum and as a template for national and regional accreditation standards. Promotion of national accreditation systems will have a pivotal influence on future international appraisal of medical education. Information about accreditation status - the agencies involved and the criteria and procedure used - will be an essential component of new Global Directories of Health Professions Educational Institutions. According to an agreement between the WHO and the University of Copenhagen (UC), these Directories (the Avicenna Directories) will be developed and published by the UC with the assistance of the WFME, starting with renewal of the WHO World Directory of Medical Schools, and sequentially expanding to cover educational institutions for other health professions. The Directories will be a foundation for international meta-recognition ("accrediting the

Space Station UCS antenna pattern computation and measurement. [UHF Communication Subsystem

NASA Technical Reports Server (NTRS)

Hwu, Shian U.; Lu, Ba P.; Johnson, Larry A.; Fournet, Jon S.; Panneton, Robert J.; Ngo, John D.; Eggers, Donald S.; Arndt, G. D.

1993-01-01

The purpose of this paper is to analyze the interference to the Space Station Ultrahigh Frequency (UHF) Communication Subsystem (UCS) antenna radiation pattern due to its environment - Space Station. A hybrid Computational Electromagnetics (CEM) technique was applied in this study. The antenna was modeled using the Method of Moments (MOM) and the radiation patterns were computed using the Uniform Geometrical Theory of Diffraction (GTD) in which the effects of the reflected and diffracted fields from surfaces, edges, and vertices of the Space Station structures were included. In order to validate the CEM techniques, and to provide confidence in the computer-generated results, a comparison with experimental measurements was made for a 1/15 scale Space Station mockup. Based on the results accomplished, good agreement on experimental and computed results was obtained. The computed results using the CEM techniques for the Space Station UCS antenna pattern predictions have been validated.

Corresponding color datasets and a chromatic adaptation model based on the OSA-UCS system.

PubMed

Oleari, Claudio

2014-07-01

Today chromatic adaptation transforms (CATs) are reconsidered, since their mathematical inconsistency has been shown in Color Res. Appl.38, 188 (2013) and by the CIE technical committee TC 8-11: CIECAM02 Mathematics. In 2004-2005 the author proposed an adaptation transform based on the uniform color scale system of the Optical Society of America (OSA-UCS) [J. Opt. Soc. Am. A21, 677 (2004); Color Res. Appl. 30, 31 (2005)] that transforms the cone-activation stimuli into adapted stimuli. The present work considers all the 37 available corresponding color (CC) datasets selected by CIE and (1) shows that the adapted stimuli obtained from CC data are defined up to an unknown transformation, and an unambiguous definition of the adapted stimuli requires additional hypotheses or suitable experimental data (as it is in the OSA-UCS system); (2) produces a CAT, represented by a linear transformation between CCs, associated with any CC dataset, whose high quality measured in ΔE units discards the possibility of nonlinear transformations; (3) analyzes these color-conversion matrices in a heuristic way with a reference adaptation that is approximately that of the OSA-UCS adapted colors for the D65 illuminant and particularly shows accordance with the Hunt effect and the Bezold-Brücke hue shift; (4) proposes the measurements of CC stimuli with a reference adaptation equal to that of the visual situation of the OSA-UCS system for defining adapted colors for any considered illumination adaptation and therefore for defining a general CAT formula.

Medical resource utilization and associated costs in patients with ulcerative colitis in the UK: a chart review analysis.

PubMed

Bodger, Keith; Yen, Linnette; Szende, Agota; Sharma, Gunjan; Chen, Yaozhu J; McDermott, John; Hodgkins, Paul

2014-02-01

Limited evidence is available on the economic burden of ulcerative colitis (UC) in the UK, particularly relating to the impact of relapse frequency on direct medical costs. This study identifies and assesses medical resource utilization (MRU) and associated direct costs in mild and moderate UC patients in the UK. A retrospective chart review of patients with mild-to-moderate UC diagnosed at least 1 year before the study was performed. From 33 general practitioner (GP) and 34 gastroenterologist sites, charts of the last three UC patients fulfilling the inclusion criteria were reviewed. Descriptive statistics were calculated for MRU and 2011 costs (GB£) by number of relapses. The study population included 201 patients with a mean age of 39.9 years; 44% were women and the mean disease duration was 7.4 years. UC-related costs of each MRU category increased with the number of relapses. Comparing patients without relapse with those with more than two relapses, the mean annual UC-related costs were £14 versus £2556 for hospitalizations; £218 versus £988 for visits (including nurse, GP, specialist, and other visits); £21 versus £1303 for procedures; £17 versus £188 for diagnostics; and £1168 versus £6660 for all-cause total costs. Age, sex, and site of data reporting (GP vs. gastroenterologist) were not associated with MRU or costs. Patients with mild-to-moderate UC incurred considerable costs that increased markedly with the number of relapses. These findings support the importance of maintenance therapies in UC that reduce or prevent relapses. Quantifying the relationship between relapse rate and costs will inform future health economic studies.

Brownfields Davis Bacon for Cleanup Grants: Petroleum for Non-Profit Entities

EPA Pesticide Factsheets

Terms & conditions specify how Recipients will assist EPA in meeting its Davis Bacon responsibilities when DB applies to EPA awards of financial assistance under the Recovery Act or any other statute which makes DB applicable to EPA financial assistance.

Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

PubMed Central

2013-01-01

Background UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis. The purpose of this study was to assess the efficacy and tolerability of UC-II in moderating joint function and joint pain due to strenuous exercise in healthy subjects. Methods This randomized, double-blind, placebo-controlled study was conducted in healthy subjects who had no prior history of arthritic disease or joint pain at rest but experienced joint discomfort with physical activity. Fifty-five subjects who reported knee pain after participating in a standardized stepmill performance test were randomized to receive placebo (n = 28) or the UC-II (40 mg daily, n = 27) product for 120 days. Joint function was assessed by changes in degree of knee flexion and knee extension as well as measuring the time to experiencing and recovering from joint pain following strenuous stepmill exertion. Results After 120 days of supplementation, subjects in the UC-II group exhibited a statistically significant improvement in average knee extension compared to placebo (81.0 ± 1.3º vs 74.0 ± 2.2º; p = 0.011) and to baseline (81.0 ± 1.3º vs 73.2 ± 1.9º; p = 0.002). The UC-II cohort also demonstrated a statistically significant change in average knee extension at day 90 (78.8 ± 1.9º vs 73.2 ± 1.9º; p = 0.045) versus baseline. No significant change in knee extension was observed in the placebo group at any time. It was also noted that the UC-II group exercised longer before experiencing any initial joint discomfort at day 120 (2.8 ± 0.5 min, p = 0.019), compared to baseline (1.4 ± 0.2 min). By contrast, no significant changes were seen in the placebo group. No product related adverse events were observed during the study. At study conclusion, five

Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.

PubMed

Lugo, James P; Saiyed, Zainulabedin M; Lau, Francis C; Molina, Jhanna Pamela L; Pakdaman, Michael N; Shamie, Arya Nick; Udani, Jay K

2013-10-24

UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis. The purpose of this study was to assess the efficacy and tolerability of UC-II in moderating joint function and joint pain due to strenuous exercise in healthy subjects. This randomized, double-blind, placebo-controlled study was conducted in healthy subjects who had no prior history of arthritic disease or joint pain at rest but experienced joint discomfort with physical activity. Fifty-five subjects who reported knee pain after participating in a standardized stepmill performance test were randomized to receive placebo (n = 28) or the UC-II (40 mg daily, n = 27) product for 120 days. Joint function was assessed by changes in degree of knee flexion and knee extension as well as measuring the time to experiencing and recovering from joint pain following strenuous stepmill exertion. After 120 days of supplementation, subjects in the UC-II group exhibited a statistically significant improvement in average knee extension compared to placebo (81.0 ± 1.3º vs 74.0 ± 2.2º; p = 0.011) and to baseline (81.0 ± 1.3º vs 73.2 ± 1.9º; p = 0.002). The UC-II cohort also demonstrated a statistically significant change in average knee extension at day 90 (78.8 ± 1.9º vs 73.2 ± 1.9º; p = 0.045) versus baseline. No significant change in knee extension was observed in the placebo group at any time. It was also noted that the UC-II group exercised longer before experiencing any initial joint discomfort at day 120 (2.8 ± 0.5 min, p = 0.019), compared to baseline (1.4 ± 0.2 min). By contrast, no significant changes were seen in the placebo group. No product related adverse events were observed during the study. At study conclusion, five individuals in the UC-II cohort

20 CFR 603.23 - What information must State UC agencies obtain from other agencies, and crossmatch with wage...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What information must State UC agencies obtain from other agencies, and crossmatch with wage information, for purposes of an IEVS? 603.23 Section 603.23 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL-STATE UNEMPLOYMENT COMPENSATION (UC) PROGRAM;...

Role of oral nitrate in the nitrosation of ( UC)proline by conventional microflora and germ-free rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mallett, A.K.; Rowland, I.R.; Walters, D.G.

1985-11-01

The urinary excretion of N-nitroso-L-(U- UC)proline by conventional microflora and germ free rats was used to assess the role of the gut bacteria and oral nitrate in the endogenous formation of N-nitroso compounds. The formation of nitrosoproline was qualitatively similar in conventional and germfree rats suggesting no involvement of the intestinal flora in this reaction. Furthermore, nitrosamino acid production was similar following the administration of nitrate and (U- UC)proline or (U- UC)proline alone, demonstrating no involvement of exogenous nitrate under the conditions of the experiment. Dietary contamination with nitrate/nitrite was negligible. The results are consistent with the suggestion that nitrate/nitritemore » reserves in the body are important in the formation of nitrosoproline in vivo.« less

78 FR 35022 - Parker-Davis Project-Rate Order No. WAPA-162

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... DEPARTMENT OF ENERGY Western Area Power Administration Parker-Davis Project-Rate Order No. WAPA-162 AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Proposed Extension of Firm Electric and Transmission Service Formula Rates. SUMMARY: The Western Area Power Administration (Western...

UNIVERSITY OF CALIFORNIA – CENTER FOR ENVIRONMENTAL IMPLICATIONS OF NANOTECHNOLOGY (UC-CEIN)

EPA Science Inventory

EPA GRANT NUMBER: 0830117
Title: University of California – Center for Environmental Implications of Nanotechnology (UC-CEIN)
Investigator: Andre E. Nel
Institution: University of California - Los Angeles
EPA Project Officer: Nor...

2. VIEW OF SWITCHBACKS IN FORESTA ROAD (OLD DAVIS CUTOFF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW OF SWITCHBACKS IN FORESTA ROAD (OLD DAVIS CUT-OFF ROAD). NOTE FORESTA ROAD BRIDGE IN LOWER LEFT. ROAD CURVE HIDDEN IN TREES AT CENTER. NOTE ROAD CUT AT LEFT. LOOKING SSW. GIS: N-37"40'47.4"/W-119"47'22.2 - Foresta Road, Yosemite Village, Mariposa County, CA

The Compleat Teacher-Scholar: An Interview with Stephen F. Davis

ERIC Educational Resources Information Center

Buskist, William

2009-01-01

Stephen F. Davis is Emeritus Professor of Psychology at Emporia State University. He served as the 2002-2003 Knapp Distinguished Professor of Arts and Sciences at the University of San Diego. Currently, he is Distinguished Guest Professor at Morningside College and Visiting Distinguished Professor of Psychology at Texas Wesleyan University. Since…

Results of the 2008-09 Campus Travel Survey

DOT National Transportation Integrated Search

2009-09-24

The campus travel survey is a joint effort by the Transportation & Parking Services (TAPS) on campus and the Sustainable Transportation Center, part of the Institute of Transportation Studies at UC Davis, meant to be administered annually each fall b...

Student-to-Student Harassment: The Impact of "Davis v. Monroe."

ERIC Educational Resources Information Center

Grube, Beth; Lens, Vicki

2003-01-01

This article focuses on student-to-student harassment, discussing incidents of harassment in schools, the effects on students, and the reasons it occurs in schools. The legal framework is reviewed with attention to the new legal standard established by the Supreme Court ruling in "Davis v. Monroe County Board of Education." Discusses the…

33 CFR 100.1102 - Marine Events on the Colorado River, between Davis Dam (Bullhead City, Arizona) and Headgate Dam...

Code of Federal Regulations, 2011 CFR

2011-07-01

... River, between Davis Dam (Bullhead City, Arizona) and Headgate Dam (Parker, Arizona). 100.1102 Section... Davis Dam (Bullhead City, Arizona) and Headgate Dam (Parker, Arizona). (a) General. Sponsors are... Roadrunner Resort and Headgate Dam). Bullhead City Boat Drags Sponsor: Sunshine Promotions Date: 2 to 4...

33 CFR 100.1102 - Marine Events on the Colorado River, between Davis Dam (Bullhead City, Arizona) and Headgate Dam...

Code of Federal Regulations, 2010 CFR

2010-07-01

... River, between Davis Dam (Bullhead City, Arizona) and Headgate Dam (Parker, Arizona). 100.1102 Section... Davis Dam (Bullhead City, Arizona) and Headgate Dam (Parker, Arizona). (a) General. Sponsors are... Roadrunner Resort and Headgate Dam). Bullhead City Boat Drags Sponsor: Sunshine Promotions Date: 2 to 4...

Germplasm Management in the Post-genomics Era-a case study with lettuce

USDA-ARS?s Scientific Manuscript database

High-throughput genotyping platforms and next-generation sequencing technologies revolutionized our ways in germplasm characterization. In collaboration with UC Davis Genome Center, we completed a project of genotyping the entire cultivated lettuce (Lactuca sativa L.) collection of 1,066 accessions ...

Effects of defoliation in the developing leaf zone on young Populus Xeuramericana plants. II. Distribution of UC-photosynthate after defoliation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bassman, J.H.; Dickmann, D.I.

Patterns of UC-photosynthate distribution in growth chamber-grown Populus xeuramericana cv. Negrito de Granada were determined 24 h, 3 weeks, and 5 weeks after defoliation in the developing leaf zone. Translocation patterns were determined by exposing leaves below, within, or above the defoliated zone to UCO2 and determining UC distribution within the plant after 48 h. Translocation patterns were altered within 24 h after defoliation. When leaves below or remaining tissue of leaves within the zone of defoliation were exposed to UCO2, a greater percentage of UC-photosynthate was transported to the expanding shoot and lateral branches and less to the rootsmore » in defoliated plants compared to controls. Little difference between defoliated and control plants and UC distribution occurred when new leaves produced subsequent to defoliation were exposed to UCO2. By 5 weeks after defoliation there was little difference in patterns of UC distribution between defoliated and control plants. These results substantiate biomass partitioning data which showed that a single defoliation of young poplar plants did not affect diameter or height growth, whereas leaf growth was stimulated and root growth reduced.« less

Quantum cloning disturbed by thermal Davies environment

NASA Astrophysics Data System (ADS)

Dajka, Jerzy; Łuczka, Jerzy

2016-06-01

A network of quantum gates designed to implement universal quantum cloning machine is studied. We analyze how thermal environment coupled to auxiliary qubits, `blank paper' and `toner' required at the preparation stage of copying, modifies an output fidelity of the cloner. Thermal environment is described in terms of the Markovian Davies theory. We show that such a cloning machine is not universal any more but its output is independent of at least a part of parameters of the environment. As a case study, we consider cloning of states in a six-state cryptography's protocol. We also briefly discuss cloning of arbitrary input states.

Water resources of Jefferson Davis Parish, Louisiana

USGS Publications Warehouse

White, Vincent E.; Prakken, Lawrence B.

2014-01-01

Information concerning the availability, use, and quality of water in Jefferson Davis Parish, Louisiana, is critical for proper water-supply management. The purpose of this fact sheet is to present information that can be used by water managers, parish residents, and others for stewardship of this vital resource. Information on the availability, past and current use, use trends, and water quality from groundwater and surface-water sources in the parish is presented. Previously published reports and data stored in the U.S. Geological Survey’s National Water Information System (http://waterdata.usgs.gov/nwis) are the primary sources of the information presented here.

Prehospital Air Medical Plasma (PAMPer) Trial

DTIC Science & Technology

2015-07-01

Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204...Clifford Calloway MD, PhD, Associate Professor of Emergency Medicine, University of Pittsburgh Mark Yazer, MD, Medical Director Centralized...Transfusion Service; University of Pittsburgh Barbara Early, RN, BSN, CCRC, MACRO CRC Director , University of Pittsburgh C. Investigators at other

Two Billion Cars: What it Means for Climate and Energy Policy

ScienceCinema

Daniel Sperling

2017-12-09

April 13, 2009: Daniel Sperling, director of the Institute of Transportation Studies at UC Davis, presents the next installment of Berkeley Lab's Environmental Energy Technologies Divisions Distinguished Lecture series. He discusses Two Billion Cars and What it Means for Climate and Energy Policy.

Two Billion Cars: What it Means for Climate and Energy Policy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel Sperling

2009-04-15

April 13, 2009: Daniel Sperling, director of the Institute of Transportation Studies at UC Davis, presents the next installment of Berkeley Lab's Environmental Energy Technologies Divisions Distinguished Lecture series. He discusses Two Billion Cars and What it Means for Climate and Energy Policy.

Brownfields Davis Bacon for Cleanup Grants: Hazardous Substances for Non-Profit Entities

EPA Pesticide Factsheets

The following terms and conditions specify how Recipients will assist EPA in meeting its Davis Bacon (DB) responsibilities when DB applies to EPA awards of financial assistance under any other statute which makes DB applicable to EPA financial assistance.

Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism.

PubMed

Chen, Ke; Wang, Ding; Du, Wei Ting; Han, Zhi-Bo; Ren, He; Chi, Ying; Yang, Shao Guang; Zhu, Delin; Bayard, Francis; Han, Zhong Chao

2010-06-01

Human umbilical-cord-derived mesenchymal stem cells (hUC-MSCs) constitute an attractive alternative to bone-marrow-derived MSCs for potential clinical applications because of easy preparation and lower risk of viral contamination. In this study, both proliferation of human peripheral blood mononuclear cells (hPBMCs) and their IFN-gamma production in response to mitogenic or allogeneic stimulus were effectively inhibited by hUC-MSCs. Co-culture experiments in transwell systems indicated that the suppression was largely mediated by soluble factor(s). Blocking experiments identified prostaglandin E(2) (PGE(2)) as the major factor, because inhibition of PGE(2) synthesis almost completely mitigated the immunosuppressive effects, whereas neutralization of TGF-beta, IDO, and NO activities had little effects. Moreover, the inflammatory cytokines, IFN-gamma and IL-1beta, produced by hPBMCs upon activation notably upregulated the expression of cyclooxygenase-2 (COX-2) and the production of PGE(2) by hUC-MSCs. In conclusion, our data have demonstrated for the first time the PGE(2)-mediated mechanism by which hUC-MSCs exert their immunomodulatory effects. Copyright 2010 Elsevier Inc. All rights reserved.

Population ecology of polar bears in Davis Strait, Canada and Greenland

USGS Publications Warehouse

Peacock, Elizabeth; Taylor, Mitchell K.; Laake, Jeffrey L.; Stirling, Ian

2013-01-01

Until recently, the sea ice habitat of polar bears was understood to be variable, but environmental variability was considered to be cyclic or random, rather than progressive. Harvested populations were believed to be at levels where density effects were considered not significant. However, because we now understand that polar bear demography can also be influenced by progressive change in the environment, and some populations have increased to greater densities than historically lower numbers, a broader suite of factors should be considered in demographic studies and management. We analyzed 35 years of capture and harvest data from the polar bear (Ursus maritimus) subpopulation in Davis Strait, including data from a new study (2005–2007), to quantify its current demography. We estimated the population size in 2007 to be 2,158 ± 180 (SE), a likely increase from the 1970s. We detected variation in survival, reproductive rates, and age-structure of polar bears from geographic sub-regions. Survival and reproduction of bears in southern Davis Strait was greater than in the north and tied to a concurrent dramatic increase in breeding harp seals (Pagophilus groenlandicus) in Labrador. The most supported survival models contained geographic and temporal variables. Harp seal abundance was significantly related to polar bear survival. Our estimates of declining harvest recovery rate, and increasing total survival, suggest that the rate of harvest declined over time. Low recruitment rates, average adult survival rates, and high population density, in an environment of high prey density, but deteriorating and variable ice conditions, currently characterize the Davis Strait polar bears. Low reproductive rates may reflect negative effects of greater densities or worsening ice conditions.

Using Optical Markers of Non-dysplastic Rectal Epithelial Cells to Identify Patients With Ulcerative Colitis (UC) - Associated Neoplasia

PubMed Central

Bista, Rajan K.; Brentnall, Teresa A.; Bronner, Mary P.; Langmead, Christopher J.; Brand, Randall E.; Liu, Yang

2011-01-01

BACKGROUND Current surveillance guidelines for patients with long-standing ulcerative colitis (UC) recommend repeated colonoscopy with random biopsies, which is time-consuming, discomforting and expensive. A less invasive strategy is to identify neoplasia by analyzing biomarkers from the more accessible rectum to predict the need for a full colonoscopy. The goal of this pilot study is to evaluate whether optical markers of rectal mucosa derived from a novel optical technique – partial-wave spectroscopic microscopy (PWS) could identify UC patients with high-grade dysplasia (HGD) or cancer (CA) present anywhere in their colon. METHODS Banked frozen non-dysplastic mucosal rectal biopsies were used from 28 UC patients (15 without dysplasia and 13 with concurrent HGD or CA). The specimen slides were made using a touch prep method and underwent PWS analysis. We divided the patients into two groups: 13 as a training set and an independent 15 as a validation set. RESULTS We identified six optical markers, ranked by measuring the information gain with respect to the outcome of cancer. The most effective markers were selected by maximizing the cross validated training accuracy of a Naive Bayes classifier. The optimal classifier was applied to the validation data yielding 100% sensitivity and 75% specificity. CONCLUSIONS Our results indicate that the PWS-derived optical markers can accurately predict UC patients with HGD/CA through assessment of rectal epithelial cells. By aiming for a high sensitivity, our approach could potentially simplify the surveillance of UC patients and improve overall resource utilization by identifying patients with HGD/CA who should proceed with colonoscopy. PMID:21351200

The Davis Social Environment-1990: A Report of Student Opinions.

ERIC Educational Resources Information Center

Low, Jane M.

A study was done to examine student opinion of the social environment on the University of California Davis campus in Spring 1990 as a follow up to a similar study conducted in 1987. The study used the Student Opinion Survey and mailed it to a stratified random sample of 1,649 students. Of the surveys sent, 57.7 percent were returned. The…

The Soldier Medic Mettle Study

DTIC Science & Technology

2011-10-01

Editorial Manager ® and Preprint Manager ® from Aries Systems Corporation issues on the battlefield. For Medics, this should be from two perspectives ...D.T. (2000). Tactical management of urban warfare casualties in special operations . Military Medicine, 165(1), 1-48. 2. United States Department...Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202

Study on Incentives for Glaucoma Medication Adherence (SIGMA): study protocol for a randomized controlled trial to increase glaucoma medication adherence using value pricing.

PubMed

Bilger, Marcel; Wong, Tina T; Howard, Kaye L; Lee, Jia Yi; Toh, Ai Nee; John, Geraldine; Lamoureux, Ecosse L; Finkelstein, Eric A

2016-07-15

Many glaucoma patients do not adhere to their medication regimens because they fail to internalize the (health) costs of non-adherence, which may not occur until years or decades later. Behavioural economic theory suggests that adherence rates can be improved by offering patients a near-term benefit. Our proposed strategy is to offer adherence-contingent rebates on medication and check-up costs. This form of value pricing (VP) ensures that rebates are granted only to those most likely to benefit. Moreover, by leveraging loss aversion, rebates are expected to generate a stronger behavioural response than equivalent financial rewards. The main objective of the Study on Incentives for Glaucoma Medication Adherence (SIGMA) is to test the VP approach relative to usual care (UC) in improving medication adherence. SIGMA is a randomized, controlled, open-label, single-centre superiority trial with two parallel arms. A total of 100 non-adherent (Morisky Medication Adherence Scale ≤6) glaucoma patients from the Singapore National Eye Centre are block-randomized (blocking factor: single versus multiple medications users) into the VP and UC arms in a 1:1 ratio. The treatment received by VP patients will be strictly identical to that received by UC patients, with the only exception being that VP patients can earn either a 50 % or 25 % rebate on their glaucoma-related healthcare costs conditional on being adherent on at least 90 % or 75 % of days as measured by a medication event monitoring system. Masking the arm allocation will be precluded by the behavioural nature of the intervention but blocking size will not be disclosed to protect concealment. The primary outcome is the mean change from baseline in percentage of adherent days at month 6. A day will be counted as adherent when the patients take all their medication(s) within the appropriate dosing windows. This trial will provide evidence on whether adherence-contingent rebates can improve medication adherence among

Formal assessment instrument for ensuring the security of NASA's networks, systems and software

NASA Technical Reports Server (NTRS)

Gilliam, D. P.; Powell, J. D.; Sherif, J.

2002-01-01

To address the problem of security for NASA's networks, systems and software, NASA has funded the Jet Propulsion Lab in conjunction with UC Davis to begin work on developing a software security assessment instrument for use in the software development and maintenance life cycle.

California's county hospitals and the University of California graduate medical education system. Current issues and future directions.

PubMed

Jameson, W J; Pierce, K; Martin, D K

1998-05-01

California's county hospitals train 45% of the state's graduate medical residents, including 33% of residents in the University of California system. This paper describes the interrelationships of California's county hospitals and the University of California (UC) graduate medical education (GME) programs, highlighting key challenges facing both systems. The mission of California's county health care systems is to serve all who need health care services regardless of ability to pay. Locating UC GME programs in county hospitals helps serve the public missions of both institutions. Such partnerships enhance the GME experience of UC residents, provide key primary care training opportunities, and ensure continued health care access for indigent and uninsured populations. Only through affiliation with university training programs have county hospitals been able to run the cost-effective, quality programs that constitute an acceptable safety net for the poor. Financial stress, however, has led county hospitals and UC's GME programs to advocate for reform in both GME financing and indigent care funding. County hospitals must participate in constructing strategies for GME reform to assure that GME funding mechanisms provide for equitable compensation of county hospitals' essential role. Joint advocacy will also be essential in achieving significant indigent care policy reform.

Overexpressed Calponin3 by Subsonic Vibration Induces Neural Differentiation of hUC-MSCs by Regulating the Ionotropic Glutamate Receptor.

PubMed

Kim, Hyun-Jung; Kim, Jin-Hee; Song, Yeo-Ju; Seo, Young-Kwon; Park, Jung-Keug; Kim, Chan-Wha

2015-09-01

In this study, we used proteomics to investigate the effects of sonic vibration (SV) on mesenchymal stem cells derived from human umbilical cords (hUC-MSCs) during neural differentiation to understand how SV enhances neural differentiation of hUC-MSCs. We investigated the levels of gene and protein related to neural differentiation after 3 or 5 days in a group treated with 40-Hz SV. In addition, protein expression patterns were compared between the control and the 40-Hz SV-treated hUC-MSC groups via a proteomic approach. Among these proteins, calponin3 (CNN3) was confirmed to have 299 % higher expression in the 40-Hz SV stimulated hUC-MSCs group than that in the control by Western blotting. Notably, overexpression of CNN3-GFP in Chinese hamster ovary (CHO)-K1 cells had positive effects on the stability and reorganization of F-actin compared with that in GFP-transfected cells. Moreover, CNN3 changed the morphology of the cells by making a neurite-like form. After being subjected to SV, messenger RNA (mRNA) levels of glutamate receptors such as PSD95, GluR1, and NR1 as well as intracellular calcium levels were upregulated. These results suggest that the activity of glutamate receptors increased because of CNN3 characteristics. Taken together, these results demonstrate that overexpressed CNN3 during SV increases expression of glutamate receptors and promotes functional neural differentiation of hUC-MSCs.

76 FR 21253 - Safety Zone; M/V DAVY CROCKETT, Columbia River

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

...-AA00 Safety Zone; M/V DAVY CROCKETT, Columbia River AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The U.S. Coast Guard is extending and expanding the emergency safety zone established on... January 28, 2011. The safety zone is necessary to help ensure the safety of the response workers and...

76 FR 73511 - Safety Zone; M/V DAVY CROCKETT, Columbia River

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

...-AA00 Safety Zone; M/V DAVY CROCKETT, Columbia River AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The U.S. Coast Guard is extending the enforcement period of a safety zone established on... sight at approximate river mile 117. The original safety zone was established on January 28, 2011. The...

76 FR 34862 - Safety Zone; M/V DAVY CROCKETT, Columbia River

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

...-AA00 Safety Zone; M/V DAVY CROCKETT, Columbia River AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The U.S. Coast Guard is extending the enforcement of a safety zone established on the... original safety zone was established on January 28, 2011. The safety zone is necessary to help ensure the...

U.C. Davis high energy particle physics research: Technical progress report -- 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Summaries of progress made for this period is given for each of the following areas: (1) Task A--Experiment, H1 detector at DESY; (2) Task C--Experiment, AMY detector at KEK; (3) Task D--Experiment, fixed target detectors at Fermilab; (4) Task F--Experiment, PEP detector at SLAC and pixel detector; (5) Task B--Theory, particle physics; and (6) Task E--Theory, particle physics.

What Was It like? Being in the Pioneer Class at UC Merced

ERIC Educational Resources Information Center

Perry, Lisa

2007-01-01

Entering the UC Merced campus and turning onto Scholars Lane, students saw, in this order, large cow pastures surrounding the campus, tall chainlink fences enclosing construction materials, orange fences stating "limits of construction," and across the small road, the residence facilities. Students who were willing to brave this…

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

Shared Medical Appointments: Impact on Clinical and Quality Outcomes in Veterans With Diabetes.

PubMed

Harris, Marianne D; Kirsh, Susan; Higgins, Patricia A

2016-01-01

Managing diabetes poses substantial challenges to the over 29.1 million Americans afflicted, and is financially overwhelming to the US health care system. One potential strategy is utilizing a group approach to care delivery or shared medical appointment (SMA). The purpose of this 3-year retrospective VA study was to investigate differences in clinical and quality outcome measures in veterans with type 2 diabetes who used SMAs and those who received only usual care (UC) one-on-one with their doctor. This observational, 2-group cohort study used abstracted medical records from a large Midwestern Veterans Administration hospital. Clinical outcome metrics included hemoglobin A1c (hbA1c), systolic blood pressure, low-density lipoprotein cholesterol, and emergency department (ED) visits. Quality outcomes included Veterans' Administration (VA) Department of Defense clinical practice guidelines for the management of diabetes. A total of 988 total VA cases were examined retrospectively over 3 years: 371 cases had used SMAs and 617 were in the UC cohort, and had never attended a diabetes SMA. The study period used abstracted VA medical records from 2008 to 2010. There were no statistically significant differences in HbA1c, systolic blood pressure, and ED visits between groups; however, hbA1c for individuals who attended SMAs was 8.55 (standard deviation [SD] = 1.72) and UC was 7.49 (SD = 1.28) (P < .001). All clinical outcomes were worse at baseline for the SMA cohort. UC had mean ED visits/3 years (mean = 18.62, SD = 13.53, P < .001) versus SMA participants (mean = 27.97, SD = 14.00, P <. 001), revealing a propensity for high health care utilization. SMA providers had statistically significant differences over UC cases on quality measures, including ordering annual ophthalmology and podiatry examinations (P < .001) and prescribing aspirin and angiotension-converting enzyme inhibitors (ACE-I). SMAs may provide a venue for assessing and delivering quality care for patients

Serum levels of soluble CD30 are increased in ulcerative colitis (UC) but not in Crohn's disease (CD)

PubMed Central

Giacomelli, R; Passacantando, A; Parzanese, I; Vernia, P; Klidara, N; Cucinelli, F; Lattanzio, R; Santori, E; Cipriani, P; Caprilli, R; Tonietti, G

1998-01-01

Imbalance in Th1 and Th2 subsets and their derived cytokines seems to be involved in the immune abnormalities underlying UC and CD. CD30 is a member of the tumour necrosis factor/nerve growth receptor superfamily expressed on T cells producing Th2 cytokines and released as a soluble form. In this study high levels of soluble CD30 were found in sera of UC patients independently of disease activity. Furthermore, increased titres of soluble CD30 molecule were shown, in the same patients, by mitogen-stimulated cultures of peripheral blood mononuclear cells. Our data seem to indicate that an activation of Th2 immune response is involved in the pathogenesis of UC, but not of CD. Furthermore, this finding indicates that serum soluble CD30 measurement may be helpful for differentiating these two forms of inflammatory bowel disease. PMID:9528894

Fair Employment Implication for HRD: The Case of Washington vs. Davis

ERIC Educational Resources Information Center

Sharf, James C.

1977-01-01

Examines several decisions of district and appeals courts and the Supreme Courts, both State and Federal, under title VII of the Civil Rights Act of 1964 and their implications for personnel and training management. In a reversal of the appeals court decision, the Supreme Court ruled in the case of Washington vs. Davis that the…

75 FR 3955 - Environmental Impact Statement: Davis and Weber Counties, UT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... demand in western Davis and Weber Counties. Although the exact limits of the study area have not been... Weber County. The eastern limits of the study area extend to I-15 and the western limit will be just east of the Great Salt Lake. To provide for local and regional travel demands, the regional...

75 FR 14635 - FirstEnergy Nuclear Operating Company, Davis-Besse Nuclear Power Station; Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-346; NRC-2010-0125] FirstEnergy Nuclear Operating Company, Davis-Besse Nuclear Power Station; Environmental Assessment and Finding of No Significant Impact... 14636

Total Ionizing Dose Test Report for the UC1823A Pulse Width Modulator

NASA Technical Reports Server (NTRS)

Chen, Dakai; Forney, James

2017-01-01

The purpose of this study is to examine the total ionizing dose susceptibility for the UC1823A pulse width modulator manufactured by Texas Instruments, Inc. The part is suspected to be vulnerable to enhanced low dose rate sensitivity (ELDRS).

76 FR 57717 - Endangered and Threatened Species; Take of Anadromous Fish

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

.... SUMMARY: NMFS has issued permit 15926 to UC Davis Department of Animal Science Genomic Variation Laboratory [Responsible Party: Dr. Bernie P. May], Department of Animal Science, University of California... [Responsible Party: Dave A. Vogel], P.O. Box 1210, Red Bluff, CA 96080; for purposes of scientific research...

From Stereotypes of Gender Difference to Stereotypes of Theory: A Response to Hayley Davis' Review of Deborah Tannen's "Gender and Discourse."

ERIC Educational Resources Information Center

Yerian, Keli

1997-01-01

Responding to Hayley Davis' view of gender in discourse, asserts that she misinterprets Deborah Tannen as claiming that all men are well-intentioned and misunderstood, and that this misinterpretation is a theme appearing throughout Davis' review of Tannen's collection of essays, "Gender and Discourse". (29 references) (CK)

The Effects of the Davis Symbol Mastery System to Assist a Fourth Grader with Dyslexia in Spelling: A Case Report

ERIC Educational Resources Information Center

Amsberry, Gianna; McLaughlin, T. F.; Derby, K. Mark; Waco, Teresa

2012-01-01

The purpose of this study was to determine the effectiveness of using the Davis Symbol Mastery Procedure for Words (Davis, 1994) for improving spelling skills. The participant was a fourth-grade male diagnosed with a significant learning disability. The intervention consisted of having the participant write each word, its definition, the word in a…

[Keratosis palmoplantaris maculosa seu papulosa (Davies-Colley) simulating multiple cornua cutanea].

PubMed

Schreiber, D; Stücker, M; Hoffmann, K; Bacharach-Buhles, M; Altmeyer, P

1997-08-01

Patient with extensive keratosis palmoplantaris maculosa seu papulosa (Davies-Colley) presented with multiple cutaneous horns. The clinical picture, the histology, the electro microscopic examination, the negative tumor screening and the viral classification in the tissue allowed the differentiation from other palmoplantar keratoses. The patient was treated successfully using a combination of acitretin with physical and chemical measures.

A Hydrodynamic Study of Davis Pond, Near New Orleans, LA

DTIC Science & Technology

2008-08-01

District 2004). This project will make the Barataria estuary a more prolific producer of oysters, shrimp, crab , and fish, as well as a major habitat...yards 0.9144 meters ERDC/CHL TR-08-11 1 1 Introduction The Davis Pond freshwater diversion project is a salinity -control structure located in St...Mathematical model of estuarial sediment transport. Technical Report D-77-12. Vicksburg, MS: U.S. Army Engineer Waterways Experiment Station

Production of UC-labeled gas in BACTEC Neisseria Differentiation kits by Neisseria cinerea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyce, J.M.; Mitchell, E.B. Jr.; Knapp, J.S.

1985-09-01

Six strains of Neisseria cinerea were tested in BACTEC Neisseria Differentiation kits (Johnston Laboratories, Inc., Towson, Md.), and all yielded positive glucose growth indices and negative maltose and fructose growth indices. These results were similar to those achieved with Neisseria gonorrhoeae. However, most of the N. cinerea isolates tested yielded 3-h glucose growth indices that were lower than those obtained with gonococci. UC-labeled gas was produced significantly faster by N. gonorrhoeae than by N. cinerea. Additional studies suggested that the UC-labeled gas produced by N. cinerea was carbon dioxide. N. cinerea strains were similar to Branhamella catarrhalis strains because bothmore » species failed to produce detectable acid from glucose, maltose, sucrose, fructose, and lactose in cysteine-tryptic agar media. However, in contrast to N. cinerea strains, B. catarrhalis strains did not metabolize glucose in BACTEC Neisseria Differentiation kits.« less

Initial source and site characterization studies for the U.C. Santa Barbara campus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archuleta, R.; Nicholson, C.; Steidl, J.

1997-12-01

The University of California Campus-Laboratory Collaboration (CLC) project is an integrated 3 year effort involving Lawrence Livermore National Laboratory (LLNL) and four UC campuses - Los Angeles (UCLA), Riverside (UCR), Santa Barbara (UCSB), and San Diego (UCSD) - plus additional collaborators at San Diego State University (SDSU), at Los Alamos National Laboratory and in industry. The primary purpose of the project is to estimate potential ground motions from large earthquakes and to predict site-specific ground motions for one critical structure on each campus. This project thus combines the disciplines of geology, seismology, geodesy, soil dynamics, and earthquake engineering into amore » fully integrated approach. Once completed, the CLC project will provide a template to evaluate other buildings at each of the four UC campuses, as well as provide a methodology for evaluating seismic hazards at other critical sites in California, including other UC locations at risk from large earthquakes. Another important objective of the CLC project is the education of students and other professional in the application of this integrated, multidisciplinary, state-of-the-art approach to the assessment of earthquake hazard. For each campus targeted by the CLC project, the seismic hazard study will consist of four phases: Phase I - Initial source and site characterization, Phase II - Drilling, logging, seismic monitoring, and laboratory dynamic soil testing, Phase III - Modeling of predicted site-specific earthquake ground motions, and Phase IV - Calculations of 3D building response. This report cover Phase I for the UCSB campus and incudes results up through March 1997.« less

UC Berkeley's Celebration of the International Year of Astronomy 2009

NASA Astrophysics Data System (ADS)

Cobb, B. E.; Croft, S.; Silverman, J. M.; Klein, C.; Modjaz, M.

2010-08-01

We present the astronomy outreach efforts undertaken for the International Year of Astronomy 2009 at the University of California, Berkeley. Our department-wide endeavors included a monthly public lecture series by UC Berkeley astronomers and a major astronomy outreach event during a campus-wide university "open house," which included solar observing and a Starlab Planetarium. In addition to sharing our outreach techniques and outcomes, we discuss some of our unique strategies for advertising our events to the local community.

Research on wild relatives of fruit and nut crops at the Davis repository

USDA-ARS?s Scientific Manuscript database

The USDA germplasm repository in Davis is responsible for acquiring, conserving and distributing a broad spectrum of diversity of subtropical and temperate fruit and nut species germplasm to stakeholders around the world. Currently the repository holds over 7000 accessions of germplasm including Act...

Structural studies of the cell wall polysaccharide from Lactococcus lactis UC509.9.

PubMed

Vinogradov, Evgeny; Sadovskaya, Irina; Grard, Thierry; Murphy, James; Mahony, Jennifer; Chapot-Chartier, Marie-Pierre; van Sinderen, Douwe

2018-05-22

Lactococcus lactis is the most widely utilised starter bacterial species in dairy fermentations. The L. lactis cell envelope contains polysaccharides, which, among other known functions, serve as bacteriophage receptors. Our previous studies have highlighted the structural diversity of these so-called cell wall polysaccharides (CWPSs) among L. lactis strains that could account for the narrow host range of most lactococcal bacteriophages. In the present work, we studied the CWPS of L. lactis strain UC509.9, an Irish dairy starter strain that is host to the temperate and well-characterized P335-type phage Tuc2009. The UC509.9 CWPS structure was analyzed by methylation, deacetylation/deamination, Smith degradation and 2D NMR spectroscopy. The CWPS consists of a linear backbone composed of a tetrasaccharide repeat unit, partially substituted with a branched phosphorylated oligosaccharide having a common trisaccharide and three non-stoichiometric substitutions. Copyright © 2018 Elsevier Ltd. All rights reserved.

Examination of electromagnetic powers with the example of a uc(Faraday) disc dynamo

NASA Astrophysics Data System (ADS)

Reich, Felix A.; Müller, Wolfgang H.

2018-03-01

This paper studies the mathematical form of electromagnetic powers and their influence on the balance of energy by using the example of a uc(Faraday) disc. First, two forms of energy (and balances thereof) are discussed. These employ different forms of powers, which can be distinguished w.r.t. their physical origins and their interpretations in context with the notions of supply and production. The stationary uc(Faraday) disc experiment is modeled following the description by Kovetz (Electromagnetic theory, Oxford University Press, Oxford, 2000). Concepts for formulating the electromagnetic field equations for the rotating disc are discussed, and the corresponding approximate analytical solutions are presented. Based on the obtained electromagnetic fields, the powers of the disc are analyzed for a stationary process. The conversion of mechanical power to heating and electromagnetic powering of an external resistor is explained. The paper concludes with the computation of the time evolution of the angular velocity for a magnetically induced breaking process of the disc.

Cost-effectiveness analysis of adjunct VSL#3 therapy versus standard medical therapy in pediatric ulcerative colitis.

PubMed

Park, K T; Perez, Felipe; Tsai, Raymond; Honkanen, Anita; Bass, Dorsey; Garber, Alan

2011-11-01

Inflammatory bowel diseases (IBDs) are costly chronic gastrointestinal diseases, with pediatric IBD representing increased costs per patient compared to adult disease. Health care expenditures for ulcerative colitis (UC) are >$2 billion annually. It is not clear whether the addition of VSL#3 to standard medical therapy in UC induction and maintenance of remission is a cost-effective strategy. We performed a systematic review of the literature and created a Markov model simulating a cohort of 10-year-old patients with severe UC, studying them until 100 years of age or death. We compared 2 strategies: standard medical therapy versus medical therapy + VSL#3. For both strategies, we assumed that patients progressed through escalating therapies--mesalamine, azathioprine, and infliximab--before receiving a colectomy + ileal pouch anal anastamosis (IPAA) if the 3 medical therapy options were exhausted. The primary outcome measure was the incremental cost-effectiveness ratio (ICER), defined as the difference of costs between strategies for each quality-adjusted life-year (QALY) gained. One-way sensitivity analyses were performed on variables to determine the key variables affecting cost-effectiveness. Standard medical care accrued a lifetime cost of $203,317 per patient, compared to $212,582 per patient for medical therapy + VSL#3. Lifetime QALYs gained was comparable for standard medical therapy and medical therapy + VSL#3 at 24.93 versus 25.05, respectively. Using the definition of ICER <50,000/QALY as a cost-effective intervention, medical therapy + VSL#3 produced an ICER of $79,910 per QALY gained, making this strategy cost-ineffective. Sensitivity analyses showed that 4 key parameters could affect the cost-effectiveness of the 2 strategies: cost of colectomy + IPAA, maintenance cost after surgery, probability of developing pouchitis after surgery, and the quality of life after a colectomy + IPAA. High surgical and postsurgical costs, a high probability of developing

48 CFR 53.301-1093 - Standard Form 1093, Schedule of Withholdings Under the Davis-Bacon Act and/or the Contract Work...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Standard Form 1093, Schedule of Withholdings Under the Davis-Bacon Act and/or the Contract Work Hours and Safety Standards Act... Withholdings Under the Davis-Bacon Act and/or the Contract Work Hours and Safety Standards Act. EC01MY91.076 ...

48 CFR 53.301-1093 - Standard Form 1093, Schedule of Withholdings Under the Davis-Bacon Act and/or the Contract Work...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Standard Form 1093, Schedule of Withholdings Under the Davis-Bacon Act and/or the Contract Work Hours and Safety Standards Act... Withholdings Under the Davis-Bacon Act and/or the Contract Work Hours and Safety Standards Act. EC01MY91.076 ...

Integration of pharmacists into patient-centered medical homes in federally qualified health centers in Texas.

PubMed

Wong, Shui Ling; Barner, Jamie C; Sucic, Kristina; Nguyen, Michelle; Rascati, Karen L

To describe the integration and implementation of pharmacy services in patient-centered medical homes (PCMHs) as adopted by federally qualified health centers (FQHCs) and compare them with usual care (UC). Four FQHCs (3 PCMHs, 1 UC) in Austin, TX, that provide care to the underserved populations. Pharmacists have worked under a collaborative practice agreement with internal medicine physicians since 2005. All 4 FQHCs have pharmacists as an integral part of the health care team. Pharmacists have prescriptive authority to initiate and adjust diabetes medications. The PCMH FQHCs instituted co-visits, where patients see both the physician and the pharmacist on the same day. PCMH pharmacists are routinely proactive in collaborating with physicians regarding medication management, compared with UC in which pharmacists see patients only when referred by a physician. Four face-to-face, one-on-one semistructured interviews were conducted with pharmacists working in 3 PCMH FQHCs and 1 UC FQHC to compare the implementation of PCMH with emphasis on 1) structure and workflow, 2) pharmacists' roles, and 3) benefits and challenges. On co-visit days, the pharmacist may see the patient before or after physician consultation. Pharmacists in 2 of the PCMH facilities proactively screen to identify diabetes patients who may benefit from pharmacist services, although the UC clinic pharmacists see only referred patients. Strengths of the co-visit model include more collaboration with physicians and more patient convenience. Payment that recognizes the value of PCMH is one PCMH principle that is not fully implemented. PCMH pharmacists in FQHCs were integrated into the workflow to address specific patient needs. Specifically, full-time in-house pharmacists, flexible referral criteria, proactive screening, well defined collaborative practice agreement, and open scheduling were successful strategies for the underserved populations in this study. However, reimbursement plans and provider

Developing an Instrument to Measure Socioeconomic Disparities in Quality of Care for Men with Early Stage Prostate Cancer

DTIC Science & Technology

2010-09-01

Collaboration with Moon Chen, PhD, MPH, Associate Director for Disparities and Research at UC Davis relating to prostate cancer in Asian American men. 6...Perez A, et al. A multilevel analysis of socioeconomic status and prostate cancer risk. Ann Epidemiol. 2006; 16:901-907. 9. Sultan R, Slova D, Thiel

Educational Interventions for Students with Autism

ERIC Educational Resources Information Center

Mundy, Peter, Ed.; Mastergeorge, Ann, Ed.

2012-01-01

Educational Interventions for Students with Autism offers educators a vital resource for understanding and working with autistic students. Written by nationally acclaimed experts in the field and published in collaboration with the world-renowned UC Davis M.I.N.D. Institute, the book aims to deepen educators' appreciation of the challenges…

The Effect of Assessment Style on Student Epistemologies in Introductory Physics

ERIC Educational Resources Information Center

Bowen, Mark Ryan

2011-01-01

Epistemologies were measured across two separate lecture sections of introductory algebra-based physics at UC Davis. Remarkable differences in epistemologies, as measured by the MPEX II survey were noted with one section's students (section A) showing significantly better gains in almost all epistemological categories than the other (section…

Students' Intellectual Attitudes, Aptitude, and Persistence at the University of California.

ERIC Educational Resources Information Center

Mock, Kathleen Ranlett; Yonge, George

This study examined the assumption that the meaning of college experience varies for different types of students by determining the relationships between measured personality characteristics and aptitude of students and their persistence at 3 University of California (UC) campuses--Davis, Santa Barbara and Los Angeles. It was hypothesized that the…

Energy Building Regulations: The Effect of the Federal Performance Standards on Building Code Administration and the Conservation of Energy in New Buildings.

ERIC Educational Resources Information Center

Kopper, William D.

1980-01-01

Explores the changes in the administration and enforcement of building regulations that will be engendered by the proposed federal energy building standards. Also evaluates the effectiveness of those standards in meeting congressional intent. Available from U.C. Davis Law Review, School of Law, Martin Luther King Jr. Hall, University of…

John Newsom-Davis: clinician-scientist and so much more

PubMed Central

2011-01-01

John Newsom-Davis was born in 1932 and died, aged 74, in 2007. After national service in the Royal Air Force, he read Natural Sciences at Cambridge. Following clinical studies at the Middlesex Hospital, he began research into respiratory neurophysiology with Tom Sears at the National Hospital, Queen Square, in London, and spent 1 year with Fred Plum at Cornell University in New York. After neurology specialist training at Queen Square, he became the director of the Batten Unit, continuing his interest in respiratory physiology. There he began to work on myasthenia gravis in collaboration with Ricardo Miledi at University College London and in 1978, after performing the first studies on plasma exchange in that disease, he established a myasthenia gravis research group at the Royal Free Hospital. There he investigated the role of the thymus in this disease and demonstrated an autoimmune basis for the Lambert Eaton myasthenic syndrome and ‘seronegative’ myasthenia. He was awarded the first Medical Research Council Clinical Research Professorship in 1979 but moved to Oxford in 1987 when he was elected Action Research Professor of Neurology. While at Oxford, he continued to run a very successful multidisciplinary group, researched further into the thymic abnormalities and cellular immunology of myasthenia, identified antibody-mediated mechanisms in acquired neuromyotonia, and began the molecular work that identified the genetic basis for many forms of congenital myasthenic syndrome. Meanwhile, he was also involved in university and college governance and contributed widely to the Medical Research Council, government committees, research charities and the Association of British Neurologists. Among many honours, he was elected Fellow of the Royal Society in 1991, appointed Commander of the British Empire in 1996 and made a Foreign Associate Member of the Institute of Medicine of the United States in 2001. Nearing and following retirement from Oxford, where he

Organic compounds in radiation fogs in Davis (California)

NASA Astrophysics Data System (ADS)

Herckes, Pierre; Hannigan, Michael P.; Trenary, Laurie; Lee, Taehyoung; Collett, Jeffrey L.

New stainless steel active fogwater collectors were designed and used in Davis (CA, USA) to collect fogwater for the speciation of organic matter. Organic compounds in fog samples were extracted by liquid-liquid extraction and analyzed by gas chromatography coupled to mass spectrometry. Numerous organic compounds, including various alkanes, polycyclic aromatic hydrocarbons (PAH) and alkanoic acids, have been identified in the fogwater samples. Higher molecular weight (MW) compounds are preferentially associated with an insoluble phase inside the fog drops, whereas lower molecular weight and more polar compounds are found predominantly in the dissolved phase. Concentrations in the dissolved phase were sometimes much higher than estimated by the compounds' aqueous solubilities.

Governing Academic Medical Center Systems: Evaluating and Choosing Among Alternative Governance Approaches.

PubMed

Chari, Ramya; O'Hanlon, Claire; Chen, Peggy; Leuschner, Kristin; Nelson, Christopher

2018-02-01

The ability of academic medical centers (AMCs) to fulfill their triple mission of patient care, medical education, and research is increasingly being threatened by rising financial pressures and resource constraints. Many AMCs are, therefore, looking to expand into academic medical systems, increasing their scale through consolidation or affiliation with other health care systems. As clinical operations grow, though, the need for effective governance becomes even more critical to ensure that the business of patient care does not compromise the rest of the triple mission. Multi-AMC systems, a model in which multiple AMCs are governed by a single body, pose a particular challenge in balancing unity with the needs of component AMCs, and therefore offer lessons for designing AMC governance approaches. This article describes the development and application of a set of criteria to evaluate governance options for one multi-AMC system-the University of California (UC) and its five AMCs. Based on a literature review and key informant interviews, the authors identified criteria for evaluating governance approaches (structures and processes), assessed current governance approaches using the criteria, identified alternative governance options, and assessed each option using the identified criteria. The assessment aided UC in streamlining governance operations to enhance their ability to respond efficiently to change and to act collectively. Although designed for UC and a multi-AMC model, the criteria may provide a systematic way for any AMC to assess the strengths and weaknesses of its governance approaches.

Ground water in the East Shore area, Utah. Part I. Bountiful District, Davis County

USGS Publications Warehouse

Thomas, H.E.; Nelson, W.B.

1948-01-01

The Bountiful district in Davis County, Utah, less than 10 miles from the heart of Salt Lake City, is rapidly becoming an integral part of the metropolitan area of Salt Lake City. It cannot achieve the development that its location merits unless the present water supplies are increased. The district is a fertile agricultural area favorably situated between the largest cities in the intermountain area and athwart the major routes of transportation and communication, but development of its residential, industrial, and agricultural potentialities will be restricted until existing water resources are supplemented by importation from other drainage basins that now have surplus water supplies. This conclusion is reached in the accompanying report by the Geological Survey, prepared in cooperation with the Utah State Engineer and the Davis County Water Users Association, and based on a 2-year investigation of the existing water supplies

Draft Genome Sequence of Vancomycin-Heteroresistant Staphylococcus epidermidis Strain UC7032, Isolated from Food

PubMed Central

Pietta, Ester; Bassi, Daniela; Fontana, Cecilia; Puglisi, Edoardo; Cappa, Fabrizio; Cocconcelli, Pier Sandro

2013-01-01

Staphylococcus epidermidis strain UC7032 was isolated from ready-to-eat cured meat and is heteroresistant to glycopeptide antibiotics. The draft whole-genome analysis revealed that this strain shows common characteristics typical of strains that are involved in nosocomial infections. PMID:24072859

Reactor engineering support of operations at the Davis-Besse nuclear power station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelley, D.B.

1995-12-31

Reactor engineering functions differ greatly from unit to unit; however, direct support of the reactor operators during reactor startups and operational transients is common to all units. This paper summarizes the support the reactor engineers provide the reactor operators during reactor startups and power changes through the use of automated computer programs at the Davis-Besse nuclear power station.

48 CFR 52.222-31 - Davis-Bacon Act-Price Adjustment (Percentage Method).

Code of Federal Regulations, 2010 CFR

2010-10-01

... the Davis-Bacon Act to provide for an increase in wages and fringe benefits at the exercise of each... exercise of each option to extend the term of the contract. This adjustment is the only adjustment that the Contracting Officer will make to cover any increases in wages and benefits as a result of— (1) Incorporation...

Creating an Engaging Library Orientation: First Year Experience Courses at UC San Diego

ERIC Educational Resources Information Center

Goldman, Crystal; Turnbow, Dominique; Roth, Amanda; Friedman, Lia; Heskett, Karen

2016-01-01

This article focuses on the development of an engaging library orientation module for UC San Diego First Year Experience (FYE) courses. The library module included a brief in-class presentation about research concepts and library services, an online interactive library scavenger hunt given as an in-class activity, and a homework assignment where…

UWP 011: Popular Science and Technology Writing

ERIC Educational Resources Information Center

Perrault, Sarah

2012-01-01

UWP 011: Popular Science & Technology Writing is a sophomore-level course designed as an introduction to rhetoric of science at UC Davis, a science-focused land-grant university. The course fulfills the general education requirements for written literacy and for topical breadth in arts and humanities. The catalog describes the course as…

Gender Differences in Faculty Development: A Faculty Needs Survey

ERIC Educational Resources Information Center

Seritan, Andreea L.; Iosif, Ana-Maria; Hyvonen, Shelby; Lan, Mei-Fang; Boyum, Kathleen; Hilty, Donald

2010-01-01

Objective: The authors investigated professional development needs of faculty in the Department of Psychiatry and Behavioral Sciences at the University of California (UC) Davis, while also exploring any existing differences according to gender and academic rank. Methods: An online survey was sent to 75 faculty members, and 41 responses (17 women,…

Freshmen Entering the University of California, Fall 1966.

ERIC Educational Resources Information Center

Mock, Kathleen

The report interprets data collected by the American Council on Education on freshmen at 7 University of California (UC) campuses during a fall 1966 survey of 251 colleges and universities. The 7 campuses are Davis, Berkeley, Irvine, Los Angeles, Riverside, Santa Barbara, and Santa Cruz. Students responded to questions about their backgrounds,…

The "Dirty Weather" diaries of Reverend Richard Davis: insights about early Colonial-era meteorology and climate variability for Northern New Zealand, 1839-1851

NASA Astrophysics Data System (ADS)

Lorrey, A. M.; Chappell, P. R.

2015-08-01

Reverend Richard Davis (1790-1863) was a Colonial-era missionary stationed in the Far North of New Zealand who was a key figure in the early efforts of the Church Mission Society. He kept meticulous meteorological records for the early settlements of Waimate North and Kaikohe, and his observations are preserved in a two-volume set in the rare manuscripts archive at the Auckland City Library. The Davis diary volumes are significant because they constitute some of the earliest land-based meteorological measurements that were continually chronicled for New Zealand. The diary measurements cover nine years within the 1839-1851 timespan that are broken into two parts: 1839-1844 and 1848-1851. Davis' meteorological recordings include daily 9 AM and noon temperatures and mid-day pressure measurements. Qualitative comments in the diary note prevailing wind flow, wind strength, cloud cover, climate variability impacts, bio-indicators suggestive of drought, and notes on extreme weather events. "Dirty weather" comments scattered throughout the diary describe disturbed conditions with strong winds and driving rainfall. The Davis diary entries coincide with the end of the Little Ice Age (LIA) and they indicate southerly and westerly circulation influences and cooler winter temperatures were more frequent than today. A comparison of climate field reconstructions derived from the Davis diary data and tree ring-based winter temperature reconstructions are supported by tropical coral palaeotemperature evidence. Davis' pressure measurements were corroborated using ship log data from vessels associated with iconic Antarctic exploration voyages that were anchored in the Bay of Islands, and suggest the pressure series he recorded are robust and can be used as `station data'. The Reverend Davis meteorological data are expected to make a significant contribution to the Atmospheric Circulation Reconstructions across the Earth (ACRE) project, which feeds the major data requirements for the

The "dirty weather" diaries of Reverend Richard Davis: insights about early colonial-era meteorology and climate variability for northern New Zealand, 1839-1851

NASA Astrophysics Data System (ADS)

Lorrey, Andrew M.; Chappell, Petra R.

2016-03-01

Reverend Richard Davis (1790-1863) was a colonial-era missionary stationed in the Far North of New Zealand who was a key figure in the early efforts of the Church Mission Society. He kept meticulous meteorological records for the early settlements of Waimate North and Kaikohe, and his observations are preserved in a two-volume set in the Sir George Grey Special Collections in the Auckland Central Library. The Davis diary volumes are significant because they constitute some of the earliest land-based meteorological measurements that were continually chronicled for New Zealand. The diary measurements cover nine years within the 1839-1851 time span that are broken into two parts: 1839-1844 and 1848-1851. Davis' meteorological recordings include daily 9 a.m. and noon temperatures and midday pressure measurements. Qualitative comments in the diary note prevailing wind flow, wind strength, cloud cover, climate variability impacts, bio-indicators suggestive of drought, and notes on extreme weather events. "Dirty weather" comments scattered throughout the diary describe disturbed conditions with strong winds and driving rainfall. The Davis diary entries coincide with the end of the Little Ice Age (LIA) and they indicate southerly and westerly circulation influences and cooler winter temperatures were more frequent than today. A comparison of climate field reconstructions derived from the Davis diary data and tree-ring-based winter temperature reconstructions are supported by tropical coral palaeotemperature evidence. Davis' pressure measurements were corroborated using ship log data from vessels associated with iconic Antarctic exploration voyages that were anchored in the Bay of Islands, and suggest the pressure series he recorded are robust and can be used as "station data". The Reverend Davis meteorological data are expected to make a significant contribution to the Atmospheric Circulation Reconstructions across the Earth (ACRE) project, which feeds the major data

Design and synthesis of a novel multifunctional stabilizer for highly stable uc(dl)-tetrahydropalmatine nanosuspensions and in vitro study

NASA Astrophysics Data System (ADS)

Yan, Beibei; Wang, Yancai; Wang, Lulu; Zhou, Yuqi; Shang, Xueyun; Zhao, Juan; Liu, Yangyang; Du, Juan

2018-05-01

The present study aimed to prepare stable uc(dl)-tetrahydropalmatine (uc(dl)-THP) nanosuspensions of optimized formulation with PEGylated chitosan as a multifunctional stabilizer using the antisolvent precipitation method. A central composite design project of three factors and five-level full factorial (53) was applied to design the experimental program, and response surface methodology analysis was used to optimize the experimental conditions. The effects of critical influencing factors such as PEGylated chitosan concentration, operational temperature, and ultrasonic energy on particle size and zeta potential were investigated. Under the optimization nanosuspension formulation, the particle size was 269 nm and zeta potential was at 37.4 mV. Also, the uc(dl)-THP nanosuspensions maintained good physical stability after 2 months, indicating the potential ability of the multifunctional stabilizer for stable nanosuspension formulation. Hence, the present findings indicated that PEGylated chitosan could be used as the ideal stabilizer to form a physically stable nanosuspension formulation.

Theoretical study of actinide monocarbides (ThC, UC, PuC, and AmC)

NASA Astrophysics Data System (ADS)

Pogány, Peter; Kovács, Attila; Visscher, Lucas; Konings, Rudy J. M.

2016-12-01

A study of four representative actinide monocarbides, ThC, UC, PuC, and AmC, has been performed with relativistic quantum chemical calculations. The two applied methods were multireference complete active space second-order perturbation theory (CASPT2) including the Douglas-Kroll-Hess Hamiltonian with all-electron basis sets and density functional theory with the B3LYP exchange-correlation functional in conjunction with relativistic pseudopotentials. Beside the ground electronic states, the excited states up to 17 000 cm-1 have been determined. The molecular properties explored included the ground-state geometries, bonding properties, and the electronic absorption spectra. According to the occupation of the bonding orbitals, the calculated electronic states were classified into three groups, each leading to a characteristic bond distance range for the equilibrium geometry. The ground states of ThC, UC, and PuC have two doubly occupied π orbitals resulting in short bond distances between 1.8 and 2.0 Å, whereas the ground state of AmC has significant occupation of the antibonding orbitals, causing a bond distance of 2.15 Å.

LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells.

PubMed

Chen, Ting; Gu, Chengxin; Xue, Cailin; Yang, Tao; Zhong, Yun; Liu, Shiming; Nie, Yuqiang; Yang, Hui

2017-01-01

Long non-coding RNAs (lncRNAs) have been implicated in liver carcinogenesis. We previously showed that the induction of lncRNA-uc002mbe.2 is positively associated with the apoptotic effect of trichostatin A (TSA) in hepatocellular carcinoma (HCC) cells. The current study further analyzed the role of uc002mbe.2 in TSA-induced liver cancer cell death. The level of uc002mbe.2 was markedly increased by TSA in the cytoplasm of HCC cells. Knockdown of uc002mbe.2 prohibited TSA-induced G2/M cell cycle arrest, p21 induction, and apoptosis of Huh7 cells and reversed the TSA-mediated decrease in p-AKT. RNA pull-down and RNA-binding protein immunoprecipitation (RIP) assays revealed that TSA induced an interaction between uc002mbe.2 and heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in Huh7 cells. This interaction mediated AKT deactivation and p21 induction in liver cancer cells. In an athymic xenograft mouse model, knockdown of uc002mbe.2 significantly prohibited the TSA-mediated reduction in tumor size and weight. In addition, the ability of TSA to reduce hnRNPA2B1 and p-AKT levels and induce p21 in the xenograft tumors was prevented by uc002mbe.2 knockdown. Therefore, the interaction of uc002mbe.2 and hnRNPA2B1 in mediating AKT deactivation and p21 induction is involved in the cytostatic effect of trichostatin in liver cancer cells.

LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia.

PubMed

Wang, Shouyu; Xu, Hong; Zou, Lifang; Xie, Jinyang; Wu, Hong; Wu, Bing; Yi, Zhihua; Lv, Qiulan; Zhang, Xi; Ying, Mofeng; Liu, Shuangmei; Li, Guilin; Gao, Yun; Xu, Changshui; Zhang, Chunping; Xue, Yun; Liang, Shangdong

2016-03-01

Some long non-coding RNAs (lncRNAs) participate in physiological processes that maintain cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs is involved in the onset and progression of many pathological conditions. Research has indicated that the genetic knockout of some lncRNAs in mice resulted in peri- or postnatal lethality or developmental defects. Diabetes mellitus (DM) is a major cause of peripheral neuropathy. Our studies showed that the expression levels of lncRNA uc.48+ in the diabetic rat dorsal root ganglia (DRG) and the DM patients' serum samples were increased. It suggested that lncRNA uc.48+ was involved in the pathophysiological process of DM. The aim of this study was to investigate the effects of lncRNA uc.48+ small interfering RNA (siRNA) on diabetic neuropathic pain (DNP) mediated by the P2X3 receptor in the DRG. The values of the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured by the von Frey test and Hargreaves' test, respectively. The levels of P2X3 protein and messenger RNA (mRNA) in the DRG were detected by reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and western blotting. The experiments showed that the MWT and TWL values in DM rats were lower than those in the control rats. The MWT and TWL values in DM rats treated with lncRNA uc.48+ siRNA were increased compared to those in DM rats, but there was no significant difference between the DM rat group and the DM + scramble siRNA group. The levels of P2X3 protein and mRNA in the DM DRG were higher than those in the control, while the levels of P2X3 protein and mRNA in the DG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in DM rats. The expression levels of TNF-α in the DRG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in the DM group. The phosphorylation and activation of ERK1/2 in the DM DRG were decreased by

In Vitro Evaluation of Nonnucleoside Reverse Transcriptase Inhibitors UC-781 and TMC120-R147681 as Human Immunodeficiency Virus Microbicides†

PubMed Central

Van Herrewege, Yven; Michiels, Jo; Van Roey, Jens; Fransen, Katrien; Kestens, Luc; Balzarini, Jan; Lewi, Paul; Vanham, Guido; Janssen, Paul

2004-01-01

The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV. PMID:14693562

Effects of Extra Virgin Olive Oil (EVOO) Oleocanthal and Oleacein Content on Platelet Reactivity in Healthy Adults

USDA-ARS?s Scientific Manuscript database

Effects of Extra Virgin Olive Oil (EVOO) Oleocanthal and Oleacein Content on Platelet Reactivity in Healthy Adults. Roberta R Holt1, Karan Agarwal1, Xuequi Li2, Eleni Melliou3, Theresa Pedersen1, Selina Wang2, Dan Flynn2, Prokopios Magiatis3, John W Newman1,4 1Department of Nutrition, and 2UC Davis ...

Rural Non-Commercial Research - The University of California: A Case Study.

ERIC Educational Resources Information Center

Fiske, Emmett P.; Zone, Martin A.

The University of California at Davis's (UC) Agricultural Experiment Station (AES) was used as a case study for purposes of examining how one Land Grant Institution responded to charges that its research had not followed the mandate of the Hatch Act of 1887. Focusing on "rural, noncommercial" research, data were analyzed for fiscal years…

Attracting Students to Fluid Mechanics with Coffee

NASA Astrophysics Data System (ADS)

Ristenpart, William

2016-11-01

We describe a new class developed at U.C. Davis titled "The Design of Coffee," which serves as a nonmathematical introduction to chemical engineering as illustrated by the process of roasting and brewing coffee. Hands-on coffee experiments demonstrate key engineering principles, including material balances, chemical kinetics, mass transfer, conservation of energy, and fluid mechanics. The experiments lead to an engineering design competition where students strive to make the best tasting coffee using the least amount of energy - a classic engineering optimization problem, but one that is both fun and tasty. "The Design of Coffee" started as a freshmen seminar in 2013, and it has exploded in popularity: it now serves 1,533 students per year, and is the largest and most popular elective course at U.C. Davis. In this talk we focus on the class pedagogy as applied to fluid mechanics, with an emphasis on how coffee serves as an engaging and exciting topic for teaching students about fluid mechanics in an approachable, hands-on manner.

Interview with a quality leader--Karen Davis, executive director of The Commonwealth Fund. Interview by Lecia A. Albright.

PubMed

Davis, Karen

2009-01-01

Karen Davis is president of The Commonwealth Fund, a national philanthropy engaged in independent research on health and social policy issues. Dr. Davis is a nationally recognized economist, with a distinguished career in public policy and research. Before joining the Fund, she served as chairman of the Department of Health Policy and Management at The Johns Hopkins School of Public Health, where she also held an appointment as professor of economics. She served as deputy assistant secretary for health policy in the Department of Health and Human Services from 1977 to 1980, and was the first woman to head a U.S. Public Health Service agency. Before her government career, Ms. Davis was a senior fellow at the Brookings Institution in Washington, DC; a visiting lecturer at Harvard University; and an assistant professor of economics at Rice University. A native of Oklahoma, she received her PhD in economics from Rice University, which recognized her achievements with a Distinguished Alumna Award in 1991. Ms. Davis is the recipient of the 2000 Baxter-Allegiance Foundation Prize for Health Services Research. In the spring of 2001, Ms. Davis received an honorary doctorate in human letters from John Hopkins University. In 2006, she was selected for the Academy Health Distinguished Investigator Award for significant and lasting contributions to the field of health services research in addition to the Picker Award for Excellence in the Advancement of Patient Centered Care. Ms. Davis has published a number of significant books, monographs, and articles on health and social policy issues, including the landmark books HealthCare Cost Containment, Medicare Policy, National Health Insurance: Benefits, Costs, and Consequences, and Health and the War on Poverty. She serves on the Board of Visitors of Columbia University, School of Nursing, and is on the Board of Directors of the Geisinger Health System. She was elected to the Institute of Medicine (IOM) in 1975; has served two

Long Noncoding RNA uc002yug.2 Activates HIV-1 Latency through Regulation of mRNA Levels of Various RUNX1 Isoforms and Increased Tat Expression.

PubMed

Huan, Chen; Li, Zhaolong; Ning, Shanshan; Wang, Hong; Yu, Xiao-Fang; Zhang, Wenyan

2018-05-01

The HIV-1 reservoir is a major obstacle to complete eradication of the virus. Although many proteins and RNAs have been characterized as regulators in HIV-1/AIDS pathogenesis and latency, only a few long noncoding RNAs (lncRNAs) have been shown to be closely associated with HIV-1 replication and latency. In this study, we demonstrated that lncRNA uc002yug.2 plays a key role in HIV-1 replication and latency. uc002yug.2 potentially enhances HIV-1 replication, long terminal repeat (LTR) activity, and the activation of latent HIV-1 in both cell lines and CD4 + T cells from patients. Further investigation revealed that uc002yug.2 activates latent HIV-1 through downregulating RUNX1b and -1c and upregulating Tat protein expression. The accumulated evidence supports our model that the Tat protein has the key role in the uc002yug.2-mediated regulatory effect on HIV-1 reactivation. Moreover, uc002yug.2 showed an ability to activate HIV-1 similar to that of suberoylanilide hydroxamic acid or phorbol 12-myristate 13-acetate using latently infected cell models. These findings improve our understanding of lncRNA regulation of HIV-1 replication and latency, providing new insights into potential targeted therapeutic interventions. IMPORTANCE The latent viral reservoir is the primary obstacle to curing HIV-1 disease. To date, only a few lncRNAs, which play major roles in various biological processes, including viral infection, have been identified as regulators in HIV-1 latency. In this study, we demonstrated that lncRNA uc002yug.2 is important for both HIV-1 replication and activation of latent viruses. Moreover, uc002yug.2 was shown to activate latent HIV-1 through regulating alternative splicing of RUNX1 and increasing the expression of Tat protein. These findings highlight the potential merit of targeting lncRNA uc002yug.2 as an activating agent for latent HIV-1. Copyright © 2018 American Society for Microbiology.

78 FR 13339 - Florida Petroleum Reprocessors Site; Davie, Broward County, FL; Notice of Settlement

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... ENVIRONMENTAL PROTECTION AGENCY [FRL 9785-7; CERCLA-04-2013-3755] Florida Petroleum Reprocessors... settlement with 2238 NW. 86th Street Inc. concerning the Florida Petroleum Reprocessors Site located in Davie... by Site name Florida Petroleum Reprocesssors Site by one of the following methods: www.epa.gov...

75 FR 16523 - FirstEnergy Nuclear Operating Company; Davis-Besse Nuclear Power Station; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-346; NRC-2010-0125] FirstEnergy Nuclear Operating Company; Davis-Besse Nuclear Power Station; Exemption 1.0 Background FirstEnergy Nuclear Operating Company..., letter from R.W. Borchardt, NRC, to M.S. Fertel, Nuclear Energy Institute). The licensee's request for an...

DaVIE: Database for the Visualization and Integration of Epigenetic data

PubMed Central

Fejes, Anthony P.; Jones, Meaghan J.; Kobor, Michael S.

2014-01-01

One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These issues are beginning to be observed in human DNA methylation studies, as the Illumina 450k platform and next generation sequencing-based assays grow in popularity and decrease in price. This increase in productivity is enabling new insights into epigenetics, but also requires the development of pipelines and software capable of handling the large volumes of data. The specific problems inherent in creating a platform for the storage, comparison, integration, and visualization of DNA methylation data include data storage, algorithm efficiency and ability to interpret the results to derive biological meaning from them. Databases provide a ready-made solution to these issues, but as yet no tools exist that that leverage these advantages while providing an intuitive user interface for interpreting results in a genomic context. We have addressed this void by integrating a database to store DNA methylation data with a web interface to query and visualize the database and a set of libraries for more complex analysis. The resulting platform is called DaVIE: Database for the Visualization and Integration of Epigenetics data. DaVIE can use data culled from a variety of sources, and the web interface includes the ability to group samples by sub-type, compare multiple projects and visualize genomic features in relation to sites of interest. We have used DaVIE to identify patterns of DNA methylation in specific projects and across different projects, identify outlier samples, and cross-check differentially methylated CpG sites identified in specific projects across large numbers of samples. A demonstration server has been setup using GEO data at http

Brownfields Davis Bacon for Revolving Loan Fund Grants: RLF Grants to Governmental/Quasi-Governmental Organizations

EPA Pesticide Factsheets

Terms & conditions specify how Recipients will assist EPA in meeting its Davis Bacon responsibilities when DB applies to EPA awards of financial assistance under the Recovery Act or any other statute which makes DB applicable to EPA financial assistance.

The Little Engine That Could? Analyzing the Impact of Fiechtner and Davis (1984)

ERIC Educational Resources Information Center

Arbaugh, J. B.

2016-01-01

In this commentary, the author raises the question whether there are other pearls of wisdom from early articles of BME research that are being missed because they showed up in print too soon? Arbaugh bases his reasoning's from the 1984 article by Fiechtner and Davis ("Why Some Groups Fail: A Survey of Students' Experiences with Learning…

Solar pond power plant feasibility study for Davis, California

NASA Technical Reports Server (NTRS)

Wu, Y. C.; Singer, M. J.; Marsh, H. E.; Harris, J.; Walton, A. L.

1982-01-01

The feasibility of constructing a solar pond power plant at Davis, California was studied. Site visits, weather data compilation, soil and water analyses, conceptual system design and analyses, a material and equipment market survey, conceptual site layout, and a preliminary cost estimate were studied. It was concluded that a solar pond power plant is technically feasible, but economically unattractive. The relatively small scale of the proposed plant and the high cost of importing salt resulted in a disproportionately high capital investment with respect to the annual energy production capacity of the plant. Cycle optimization and increased plant size would increase the economical attractiveness of the proposed concept.

Genetic characterization of UCS region of Pneumocystis jirovecii and construction of allelic profiles of Indian isolates based on sequence typing at three regions.

PubMed

Gupta, Rashmi; Mirdha, Bijay Ranjan; Guleria, Randeep; Kumar, Lalit; Luthra, Kalpana; Agarwal, Sanjay Kumar; Sreenivas, Vishnubhatla

2013-01-01

Pneumocystis jirovecii is an opportunistic pathogen that causes severe pneumonia in immunocompromised patients. To study the genetic diversity of P. jirovecii in India the upstream conserved sequence (UCS) region of Pneumocystis genome was amplified, sequenced and genotyped from a set of respiratory specimens obtained from 50 patients with a positive result for nested mitochondrial large subunit ribosomal RNA (mtLSU rRNA) PCR during the years 2005-2008. Of these 50 cases, 45 showed a positive PCR for UCS region. Variations in the tandem repeats in UCS region were characterized by sequencing all the positive cases. Of the 45 cases, one case showed five repeats, 11 cases showed four repeats, 29 cases showed three repeats and four cases showed two repeats. By running amplified DNA from all these cases on a high-resolution gel, mixed infection was observed in 12 cases (26.7%, 12/45). Forty three of 45 cases included in this study had previously been typed at mtLSU rRNA and internal transcribed spacer (ITS) region by our group. In the present study, the genotypes at those two regions were combined with UCS repeat patterns to construct allelic profiles of 43 cases. A total of 36 allelic profiles were observed in 43 isolates indicating high genetic variability. A statistically significant association was observed between mtLSU rRNA genotype 1, ITS type Ea and UCS repeat pattern 4. Copyright © 2012 Elsevier B.V. All rights reserved.

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.

PubMed

Fischer, Anika; Zundler, Sebastian; Atreya, Raja; Rath, Timo; Voskens, Caroline; Hirschmann, Simon; López-Posadas, Rocío; Watson, Alastair; Becker, Christoph; Schuler, Gerold; Neufert, Clemens; Atreya, Imke; Neurath, Markus F

2016-10-01

Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15. We assessed the expression of homing receptors on T cells in peripheral blood and inflamed mucosa. We studied the migration pattern and homing of Teff and Treg cells to the inflamed gut using intravital confocal microscopy and FACS in a humanised mouse model in dextran sodium sulfate-treated NSG (NOD.Cg-Prkdcscid-Il2rgtm1Wjl/SzJ) mice. Expression of GPR15 and α4β7 was significantly increased on Treg rather than Teff cells in peripheral blood of patients with UC as compared with Crohn's disease and controls. In vivo analysis in a humanised mouse model showed augmented gut homing of UC Treg cells as compared with controls. Moreover, suppression of UC (but not control) Teff and Treg cell homing was noted upon treatment with the α4β7 antibody vedolizumab. In contrast, siRNA blockade of GPR15 had only effects on homing of Teff cells but did not affect Treg homing in UC. Clinical vedolizumab treatment was associated with marked expansion of UC Treg cells in peripheral blood. α4β7 rather than GPR15 is crucial for increased colonic homing of UC Treg cells in vivo, while both receptors control UC Teff cell homing. Vedolizumab treatment impairs homing of UC Treg cells leading to their accumulation in peripheral blood with subsequent suppression of systemic Teff cell expansion. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

PubMed Central

Fischer, Anika; Zundler, Sebastian; Atreya, Raja; Rath, Timo; Voskens, Caroline; Hirschmann, Simon; López-Posadas, Rocío; Watson, Alastair; Becker, Christoph; Schuler, Gerold; Neufert, Clemens; Atreya, Imke; Neurath, Markus F

2016-01-01

Objective Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15. Design We assessed the expression of homing receptors on T cells in peripheral blood and inflamed mucosa. We studied the migration pattern and homing of Teff and Treg cells to the inflamed gut using intravital confocal microscopy and FACS in a humanised mouse model in dextran sodium sulfate-treated NSG (NOD.Cg-Prkdcscid-Il2rgtm1Wjl/SzJ) mice. Results Expression of GPR15 and α4β7 was significantly increased on Treg rather than Teff cells in peripheral blood of patients with UC as compared with Crohn’s disease and controls. In vivo analysis in a humanised mouse model showed augmented gut homing of UC Treg cells as compared with controls. Moreover, suppression of UC (but not control) Teff and Treg cell homing was noted upon treatment with the α4β7 antibody vedolizumab. In contrast, siRNA blockade of GPR15 had only effects on homing of Teff cells but did not affect Treg homing in UC. Clinical vedolizumab treatment was associated with marked expansion of UC Treg cells in peripheral blood. Conclusions α4β7 rather than GPR15 is crucial for increased colonic homing of UC Treg cells in vivo, while both receptors control UC Teff cell homing. Vedolizumab treatment impairs homing of UC Treg cells leading to their accumulation in peripheral blood with subsequent suppression of systemic Teff cell expansion. PMID:26209553

The environmental impact of sewage and wastewater outfalls in Antarctica: An example from Davis station, East Antarctica.

PubMed

Stark, Jonathan S; Corbett, Patricia A; Dunshea, Glenn; Johnstone, Glenn; King, Catherine; Mondon, Julie A; Power, Michelle L; Samuel, Angelingifta; Snape, Ian; Riddle, Martin

2016-11-15

We present a comprehensive scientific assessment of the environmental impacts of an Antarctic wastewater ocean outfall, at Davis station in East Antarctica. We assessed the effectiveness of current wastewater treatment and disposal requirements under the Protocol on Environmental Protection to the Antarctic Treaty. Macerated wastewater has been discharged from an outfall at Davis since the failure of the secondary treatment plant in 2005. Water, sediment and wildlife were tested for presence of human enteric bacteria and antibiotic resistance mechanisms. Epibiotic and sediment macrofaunal communities were tested for differences between sites near the outfall and controls. Local fish were examined for evidence of histopathological abnormalities. Sediments, fish and gastropods were tested for uptake of sewage as measured by stable isotopes of N and C. Escherichia coli carrying antibiotic resistance determinants were found in water, sediments and wildlife (the filter feeding bivalve Laternula eliptica). Fish (Trematomus bernacchii) within close proximity to the outfall had significantly more severe and greater occurrences of histopathological abnormalities than at controls, consistent with exposure to sewage. There was significant enrichment of 15 N in T. bernacchii and the predatory gastropod Neobuccinum eatoni around the outfall, providing evidence of uptake of sewage. There were significant differences between epibiotic and sediment macrofaunal communities at control and outfall sites (<1.5 km), when sites were separated into groups of similar habitat types. Benthic community composition was also strongly related to habitat and environmental drivers such as sea ice. The combined evidence indicated that the discharge of wastewater from the Davis outfall is causing environmental impacts. These findings suggest that conditions in Antarctic coastal locations, such as Davis, are unlikely to be conducive to initial dilution and rapid dispersal of wastewater as required

A change in temperature modulates defence to yellow (stripe) rust in wheat line UC1041 independently of resistance gene Yr36.

PubMed

Bryant, Ruth R M; McGrann, Graham R D; Mitchell, Alice R; Schoonbeek, Henk-Jan; Boyd, Lesley A; Uauy, Cristobal; Dorling, Steve; Ridout, Christopher J

2014-01-08

Rust diseases are of major importance in wheat production worldwide. With the constant evolution of new rust strains and their adaptation to higher temperatures, consistent and durable disease resistance is a key challenge. Environmental conditions affect resistance gene performance, but the basis for this is poorly understood. Here we show that a change in day temperature affects wheat resistance to Puccinia striiformis f. sp tritici (Pst), the causal agent of yellow (or stripe) rust. Using adult plants of near-isogenic lines UC1041 +/- Yr36, there was no significant difference between Pst percentage uredia coverage in plants grown at day temperatures of 18°C or 25°C in adult UC1041 + Yr36 plants. However, when plants were transferred to the lower day temperature at the time of Pst inoculation, infection increased up to two fold. Interestingly, this response was independent of Yr36, which has previously been reported as a temperature-responsive resistance gene as Pst development in adult UC1041 -Yr36 plants was similarly affected by the plants experiencing a temperature reduction. In addition, UC1041 -Yr36 plants grown at the lower temperature then transferred to the higher temperature were effectively resistant and a temperature change in either direction was shown to affect Pst development up to 8 days prior to inoculation. Results for seedlings were similar, but more variable compared to adult plants. Enhanced resistance to Pst was observed in seedlings of UC1041 and the cultivar Shamrock when transferred to the higher temperature. Resistance was not affected in seedlings of cultivar Solstice by a temperature change in either direction. Yr36 is effective at 18°C, refining the lower range of temperature at which resistance against Pst is conferred compared to previous studies. Results reveal previously uncharacterised defence temperature sensitivity in the UC1041 background which is caused by a change in temperature and independently of Yr36. This novel

Theoretical Model for Volume Fraction of UC, 235U Enrichment, and Effective Density of Final U 10Mo Alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devaraj, Arun; Prabhakaran, Ramprashad; Joshi, Vineet V.

2016-04-12

The purpose of this document is to provide a theoretical framework for (1) estimating uranium carbide (UC) volume fraction in a final alloy of uranium with 10 weight percent molybdenum (U-10Mo) as a function of final alloy carbon concentration, and (2) estimating effective 235U enrichment in the U-10Mo matrix after accounting for loss of 235U in forming UC. This report will also serve as a theoretical baseline for effective density of as-cast low-enriched U-10Mo alloy. Therefore, this report will serve as the baseline for quality control of final alloy carbon content

Environmental Assessment Construction of a New Hazardous Cargo Pad Davis-Monthan AFB

DTIC Science & Technology

2002-11-07

PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 355th Civil Engineer Squadron (CES/CEVA),710 Third Street,Davis-Monthan AFB,AZ,85707 8. PERFORMING...agency for certain projects. Details of the preparation of this EA are mandated by the Council of Enviromental Quality (CEQ) in the series of...Base, Tucson, Arizona." October 1996. James M. Montgomery, Consulting Engineers for US army Corps of Engineers , Omaha Dist., Apri11990

Inappropriate use of urinary catheters in patients admitted to medical wards in a university hospital.

PubMed

Fernández-Ruiz, Mario; Calvo, Beatriz; Vara, Rebeca; Villar, Rocío N; Aguado, José María

2013-10-01

The prevalence and predisposing factors were determined for inappropriate urinary catheterization (UC) among inpatients in medical wards. A cross-sectional study was conducted including all patients aged ≥ 18 years admitted to medical wards in a 1300-bed tertiary-care centre, and who had a urinary catheter in place on the day of the survey. Of 380 patients observed, 46 (12.1%) had a urinary catheter in place. Twelve of them (26.1%) were inappropriately catheterized. The most common indication for inappropriate UC was urine output monitoring in a cooperative, non-critically ill patient. Inappropriateness was associated with increased age, poor functional status, urinary incontinence, dementia, and admission from a long-term care facility. Further educational efforts should be focused on improving catheterization prescribing practices by physicians. Copyright © 2012 Elsevier España, S.L. All rights reserved.

Laser Capture Microdissection of Feline Streptomyces spp Pyogranulomatous Dermatitis and Cellulitis.

PubMed

Traslavina, R P; Reilly, C M; Vasireddy, R; Samitz, E M; Stepnik, C T; Outerbridge, C; Affolter, V K; Byrne, B A; Lowenstine, L J; White, S D; Murphy, B

2015-11-01

Suspected Streptomyces spp infections were identified in 4 cats at UC Davis Veterinary Medical Teaching Hospital between 1982 and 2011. Three had ulcerated, dark red mycetomas involving the dermis, subcutis, and fascia with fistulous tracts and/or regional lymphadenopathy. One cat had pyogranulomatous mesenteric lymphadenitis. Granulomatous inflammation in all cats contained colonies of Gram-positive, non-acid-fast organisms. All 4 cats failed to respond to aggressive medical and surgical treatment and were euthanized. Laser capture microdissection (LCM) was used to selectively harvest DNA from the affected formalin-fixed, paraffin-embedded (FFPE) tissues. Cloned amplicons from LCM-derived tissue confirmed the presence of Streptomyces spp in the dermatitis cases. Amplicons from the remaining cat with peritoneal involvement aligned with the 16S ribosomal RNA gene for Actinomycetales. Usually considered a contaminant, Streptomyces spp can be associated with refractory pyogranulomatous dermatitis and cellulitis in cats with outdoor access. LCM is useful in the diagnosis of bacterial diseases where contamination may be an issue. © The Author(s) 2014.

The Importance of Quantification: Philip M. Davis--Albert R. Mann Library, Cornell University

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

As a college student, Phil Davis intended to become a scientist. But as he studied population genetics of a family of mosses, monitoring his experiments daily, he wondered, "Is this really how I want to spend my life?" After taking time off to read philosophy and bike his way around France, his answer was, "No." Instead, he decided to advance the…

STS-47 MS Davis trains at Payload Crew Training Complex at Marshall SFC

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, Mission Specialist (MS) N. Jan Davis, wearing the Autogenic Feedback Training System 2 suit and lightweight headset, reviews a Payload Systems Handbook in the Spacelab Japan (SLJ) mockup during training at the Payload Crew Training Complex at Marshall Space Flight Center (MSFC) in Huntsville, Alabama. View provided with alternate number 92P-137.

UNC-45/CRO1/She4p (UCS) Protein Forms Elongated Dimer and Joins Two Myosin Heads Near Their Actin Binding Region

DOE Office of Scientific and Technical Information (OSTI.GOV)

H Shi; G Blobel

2011-12-31

UNC-45/CRO1/She4p (UCS) proteins have variously been proposed to affect the folding, stability, and ATPase activity of myosins. They are the only proteins known to interact directly with the motor domain. To gain more insight into UCS function, we determined the atomic structure of the yeast UCS protein, She4p, at 2.9 {angstrom} resolution. We found that 16 helical repeats are organized into an L-shaped superhelix with an amphipathic N-terminal helix dangling off the short arm of the L-shaped molecule. In the crystal, She4p forms a 193-{angstrom}-long, zigzag-shaped dimer through three distinct and evolutionary conserved interfaces. We have identified She4p's C-terminal regionmore » as a ligand for a 27-residue-long epitope on the myosin motor domain. Remarkably, this region consists of two adjacent, but distinct, binding epitopes localized at the nucleotide-responsive cleft between the nucleotide- and actin-filament-binding sites. One epitope is situated inside the cleft, the other outside the cleft. After ATP hydrolysis and Pi ejection, the cleft narrows at its base from 20 to 12 {angstrom} thereby occluding the inside the cleft epitope, while leaving the adjacent, outside the cleft binding epitope accessible to UCS binding. Hence, one cycle of higher and lower binding affinity would accompany one ATP hydrolysis cycle and a single step in the walk on an actin filament rope. We propose that a UCS dimer links two myosins at their motor domains and thereby functions as one of the determinants for step size of myosin on actin filaments.« less

Molecular structure of uranium carbides: Isomers of UC3

NASA Astrophysics Data System (ADS)

Zalazar, M. Fernanda; Rayón, Víctor M.; Largo, Antonio

2013-03-01

In this article, the most relevant isomers of uranium tricarbide are studied through quantum chemical methods. It is found that the most stable isomer has a fan geometry in which the uranium atom is bonded to a quasilinear C3 unit. Both, a rhombic and a ring CU(C2) structures are found about 104-125 kJ/mol higher in energy. Other possible isomers including linear geometries are located even higher. For each structure, we provide predictions for those molecular properties (vibrational frequencies, IR intensities, dipole moments) that could eventually help in their experimental detection. We also discuss the possible routes for the formation of the different UC3 isomers as well as the bonding situation by means of a topological analysis of the electron density.

Molecular structure of uranium carbides: isomers of UC3.

PubMed

Zalazar, M Fernanda; Rayón, Víctor M; Largo, Antonio

2013-03-21

In this article, the most relevant isomers of uranium tricarbide are studied through quantum chemical methods. It is found that the most stable isomer has a fan geometry in which the uranium atom is bonded to a quasilinear C3 unit. Both, a rhombic and a ring CU(C2) structures are found about 104-125 kJ/mol higher in energy. Other possible isomers including linear geometries are located even higher. For each structure, we provide predictions for those molecular properties (vibrational frequencies, IR intensities, dipole moments) that could eventually help in their experimental detection. We also discuss the possible routes for the formation of the different UC3 isomers as well as the bonding situation by means of a topological analysis of the electron density.

[Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis].

PubMed

Ning, Li-Qin; Ye, Bai; Shen, Hong; Lu, Wei-Min; Xu, Dan-Hua; Yan, Jing; Tan, Chang; Tang, De-Cai

2018-03-01

Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method. The findings showed that the most frequently used drugs were clearing-heat herbs, which were followed by hemostatic herbs, excreting-dampness herbs, improving-digestion herbs and tonifying-Qi herbs. At the same time, the commonly combined drugs were excavated. Finally, in order to analyze potential molecular targets of the frequently used herbs, GO enrichment analysis and KEGG signal pathway enrichment analysis were performed with bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine (BATMAN-TCM). The results indicated that Chinese herbal compounds may treat UC by activating PPAR-γ pathway and regulating intestinal inflammation. The exact mechanisms shall be verified through subsequent molecular biological experiments. Copyright© by the Chinese Pharmaceutical Association.

Developing the Master Educator: Cross Disciplinary Teaching Scholars Program for Human and Veterinary Medical Faculty

ERIC Educational Resources Information Center

Srinivasan, Malathi; Pratt, Daniel D.; Collins, John; Bowe, Constance M.; Stevenson, Frazier T.; Pinney, Stephen J.; Wilkes, Michael S.

2007-01-01

Objective: At the University of California, Davis (UCD), the authors sought to develop an institutional network of reflective educational leaders. The authors wanted to enhance faculty understanding of medical education's complexity, and improve educators' effectiveness as regional/national leaders. Methods: The UCD Teaching Scholars Program is a…

Late-time structure of the Bunch-Davies FRW wavefunction

NASA Astrophysics Data System (ADS)

Konstantinidis, George; Mahajan, Raghu; Shaghoulian, Edgar

2016-10-01

In this short note we organize a perturbation theory for the Bunch-Davies wavefunction in flat, accelerating cosmologies. The calculational technique avoids the in-in formalism and instead uses an analytic continuation from Euclidean signature. We will consider both massless and conformally coupled self-interacting scalars. These calculations explicitly illustrate two facts. The first is that IR divergences get sharper as the acceleration slows. The second is that UV-divergent contact terms in the Euclidean computation can contribute to the absolute value of the wavefunction in Lorentzian signature. Here UV divergent refers to terms involving inverse powers of the radial cutoff in the Euclidean computation. In Lorentzian signature such terms encode physical time dependence of the wavefunction.

Development of a Lifespan-Based Novel Composite Person-Reported Outcome Measure Using Data from the CINRG Duchenne Natural History Study

DTIC Science & Technology

2017-10-01

drug approval. 2. KEYWORDS: Provide a brief list of keywords (limit to 20 words). Duchenne muscular dystrophy Person-reported outcomes Health ...related quality of life Functional health assessment UC Davis / CINRG Duchenne Natural History Study 5 3. ACCOMPLISHMENTS: The PI is reminded...content, we will conduct focus group discussions with an expert advisory group of DMD clinical research professionals, health care providers, parent

Development of a biophotonics technician-training program: directions for the 21st Century

NASA Astrophysics Data System (ADS)

Shackelford, James F.; Gellman, Joel; Vasan, Srini; Hall, Robert A.; Goodwin, Don E.; Molinaro, Marco; Matthews, Dennis

2005-06-01

Albuquerque Technical Vocational Institute (TVI) is collaborating with the National Science Foundation (NSF) funded Center for Biophotonics Science and Technology (CBST) headquartered at the University of California, Davis in order to develop a biophotonics curriculum for community colleges nationwide. TVI began the formal collaboration to bring about critically needed training and education that will ultimately create new jobs and employment opportunities in the field of biophotonics. "Biophotonics" is the science of generating and harnessing light to detect, image and manipulate biological materials. CBST chose TVI as a partner because of the Institute's current high-level photonics and biotechnology programs. In addition, TVI is a part of the "Albuquerque Model" that involves exposure to photonics education from the middle school level through graduate education at the University of New Mexico. Three middle schools feed into the West Mesa High School Photonics Academy, whose students then move on to TVI for advanced training. CBST brings together scientists, industry, educators and the community to research and develop applications for biophotonics. Roughly 100 researchers-including physical scientists, life scientists, physicians and engineers from UC Davis, Lawrence Livermore National Laboratory, UC Berkeley, UC San Francisco, Alabama A&M University, Stanford University, University of Texas at San Antonio, Fisk University and Mills College-are collaborating in this rapidly developing area of research. Applications of biophotonics range from using light to image or selectively treat tumors, to sequencing DNA and identifying single biomolecules within cells.

77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

...; Submission for OMB Review; Davis Bacon Act-Price Adjustment (Actual Method) AGENCY: Department of Defense... (actual method). A notice was published in the Federal Register at 77 FR 13328, on March 6, 2012. No... Bacon Act-Price Adjustment (Actual Method), by any of the following methods: Regulations.gov : http...

LncRNA uc.48+ is involved in the diabetic immune and inflammatory responses mediated by P2X7 receptor in RAW264.7 macrophages.

PubMed

Wu, Hong; Wen, Fang; Jiang, Mei; Liu, Qiang; Nie, Yijun

2018-08-01

High glucose combined with high FFAs can contribute to the unfavorable development of type 2 diabetes mellitus (T2DM) and monocytes/macrophages are important in the occurrence and development of T2DM, which is regarded as a type of low‑grade inflammation. Although our previous study demonstrated that increased expression of P2X7 receptor (P2X7R) in peripheral blood monocytes may alter the innate immune system and that long non‑coding (lnc)RNA uc.48+ was involved in diabetic neuropathic pain, the involvement of uc.48+ mediated by the P2X7R in monocyte/macrophages during T2DM has not been reported. In the present study, the effectsof uc.48+ small interference RNA (siRNA) on factors, including the mRNA and protein expression of P2X7R, apoptosis and proliferation, levels of reactive oxygen species (ROS), cytokine levels, and expression of phosphorylated (p‑) extracellular signal‑regulated kinase (ERK)1/2, were examined in RAW264.7 macrophages following exposure to high glucose and high plasma free fatty acids (FFAs). After RAW264.7 cells were transfected with uc.48+ siRNA under high glucose conditions and FFAs treatment, the mRNA expression levels of uc.48+ and P2X7 receptor were detected by reverse transcription‑polymerase chain reaction. The protein mass of P2X7 receptor and ERK signaling pathway were assessed by western blotting. ROS and calcium concentrations, and culture supernatant cytokine content [tumor necrosis factor‑α, interleukin (IL)‑10, IL‑1β] were detected by fluorescent probes and ELISA respectively. Cell viability and apoptosis were determined by MTS test and flow cytometry, respectively. It was found that treatment of RAW264.7 cells with high glucose and FFAs, which exhibited increased expression of uc.48+, evoked P2X7R‑mediated immune and inflammatory responses through several means, including cytokine secretion, ROS formation, and activation of the ERK signaling pathway. The uc.48+ siRNA regulated these factors and thus

UCS Protein Rng3p Is Essential for Myosin-II Motor Activity during Cytokinesis in Fission Yeast

PubMed Central

Stark, Benjamin C.; James, Michael L.; Pollard, Luther W.; Sirotkin, Vladimir; Lord, Matthew

2013-01-01

UCS proteins have been proposed to operate as co-chaperones that work with Hsp90 in the de novo folding of myosin motors. The fission yeast UCS protein Rng3p is essential for actomyosin ring assembly and cytokinesis. Here we investigated the role of Rng3p in fission yeast myosin-II (Myo2p) motor activity. Myo2p isolated from an arrested rng3-65 mutant was capable of binding actin, yet lacked stability and activity based on its expression levels and inactivity in ATPase and actin filament gliding assays. Myo2p isolated from a myo2-E1 mutant (a mutant hyper-sensitive to perturbation of Rng3p function) showed similar behavior in the same assays and exhibited an altered motor conformation based on limited proteolysis experiments. We propose that Rng3p is not required for the folding of motors per se, but instead works to ensure the activity of intrinsically unstable myosin-II motors. Rng3p is specific to conventional myosin-II and the actomyosin ring, and is not required for unconventional myosin motor function at other actin structures. However, artificial destabilization of myosin-I motors at endocytic actin patches (using a myo1-E1 mutant) led to recruitment of Rng3p to patches. Thus, while Rng3p is specific to myosin-II, UCS proteins are adaptable and can respond to changes in the stability of other myosin motors. PMID:24244528

Follow the Money: Engineering at Stanford and UC Berkeley during the Rise of Silicon Valley

ERIC Educational Resources Information Center

Adams, Stephen B.

2009-01-01

A comparison of the engineering schools at UC Berkeley and Stanford during the 1940s and 1950s shows that having an excellent academic program is necessary but not sufficient to make a university entrepreneurial (an engine of economic development). Key factors that made Stanford more entrepreneurial than Cal during this period were superior…

77 FR 14504 - University of California, Davis, et al.; Notice of Decision on Applications for Duty-Free Entry...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... Shields Avenue Davis, CA 95616. Instrument: Alexsys 1000 Calorimeter. Manufacturer: Setaram... demonstrate a 10 GeV laser-plasma accelerator module with a pulse energy of 40 Joules on target and a pulse...

Cloning and Characterization of the Pyrrolomycin Biosynthetic Gene Clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. Strain UC 11065▿

PubMed Central

Zhang, Xiujun; Parry, Ronald J.

2007-01-01

The pyrrolomycins are a family of polyketide antibiotics, some of which contain a nitro group. To gain insight into the nitration mechanism associated with the formation of these antibiotics, the pyrrolomycin biosynthetic gene cluster from Actinosporangium vitaminophilum was cloned. Sequencing of ca. 56 kb of A. vitaminophilum DNA revealed 35 open reading frames (ORFs). Sequence analysis revealed a clear relationship between some of these ORFs and the biosynthetic gene cluster for pyoluteorin, a structurally related antibiotic. Since a gene transfer system could not be devised for A. vitaminophilum, additional proof for the identity of the cloned gene cluster was sought by cloning the pyrrolomycin gene cluster from Streptomyces sp. strain UC 11065, a transformable pyrrolomycin producer. Sequencing of ca. 26 kb of UC 11065 DNA revealed the presence of 17 ORFs, 15 of which exhibit strong similarity to ORFs in the A. vitaminophilum cluster as well as a nearly identical organization. Single-crossover disruption of two genes in the UC 11065 cluster abolished pyrrolomycin production in both cases. These results confirm that the genetic locus cloned from UC 11065 is essential for pyrrolomycin production, and they also confirm that the highly similar locus in A. vitaminophilum encodes pyrrolomycin biosynthetic genes. Sequence analysis revealed that both clusters contain genes encoding the two components of an assimilatory nitrate reductase. This finding suggests that nitrite is required for the formation of the nitrated pyrrolomycins. However, sequence analysis did not provide additional insights into the nitration process, suggesting the operation of a novel nitration mechanism. PMID:17158935

78 FR 59230 - Special Local Regulations; Annual Marine Events on the Colorado River, Between Davis Dam...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2013-0644] Special Local Regulations; Annual Marine Events on the Colorado River, Between Davis Dam (Bullhead City, Arizona... INFORMATION: The Coast Guard will enforce the special local regulations on the Colorado River for the...

78 FR 45523 - Davis Hydro, LLC Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On June 4, 2013, the Davis Hydro, LLC, filed an application for a..., is to grant the permit holder priority to file a license application during the permit term. A...

What Makes a Queer Family Queer? A Response to Cristyn Davies and Kerry H. Robinson

ERIC Educational Resources Information Center

Silin, Jonathan

2013-01-01

In this essay I respond to Cristyn Davies and Kerry Robinson's research on queer families by remarking on the distance GLBTQI people have travelled in the last half century. I raise critical questions about the potential gains and possible losses that may result from bringing heretofore subjugated knowledges into the school curriculum. Drawing on…

Intrinsic Information Processing and Energy Dissipation in Stochastic Input-Output Dynamical Systems

DTIC Science & Technology

2015-07-09

Crutchfield. Information Anatomy of Stochastic Equilibria, Entropy , (08 2014): 0. doi: 10.3390/e16094713 Virgil Griffith, Edwin Chong, Ryan James...Christopher Ellison, James Crutchfield. Intersection Information Based on Common Randomness, Entropy , (04 2014): 0. doi: 10.3390/e16041985 TOTAL: 5 Number...Learning Group Seminar, Complexity Sciences Center, UC Davis. Korana Burke and Greg Wimsatt (UCD), reviewed PRL “Measurement of Stochastic Entropy

Recent Changes in UC Admissions Policies. Parent/Student Guide = Unos cambios recientes en los reglamentos de ingreso de la universidad de California. Guia de padres/estudiantes.

ERIC Educational Resources Information Center

EdSource, Inc., Palo Alto, CA.

This parent/student guide describes recent changes in admissions policies at the University of California (UC). Traditionally, UC admitted the top 12.5% of high school graduating seniors, but beginning in 2001, the top 4% of students in the graduating class of every high school are eligible if they have completed 11 specific "a-f"…

Post-Vietnam military herbicide exposures in UC-123 Agent Orange spray aircraft.

PubMed

Lurker, Peter A; Berman, Fred; Clapp, Richard W; Stellman, Jeanne Mager

2014-04-01

During the Vietnam War, approximately 20 million gallons of herbicides, including ~10.5 million gallons of dioxin-contaminated Agent Orange, were sprayed by about 34 UC-123 aircraft that were subsequently returned to the United States, without decontamination or testing, to three Air Force reserve units for transport operations (~1971-1982). In 1996, observed dioxin contamination led to withdrawal of these UC-123s from public auction and to their smelting in 2009. Current Air Force and Department of Veterans Affairs policies stipulate that "dried residues" of chemical herbicides and dioxin had not lead to meaningful exposures to flight crew and maintenance personnel, who are thus ineligible for Agent Orange-related benefits or medical examinations and treatment. Sparse monitoring data are available for analysis. Three complementary approaches for modeling potential exposures to dioxin in the post-Vietnam war aircraft were employed: (1) using 1994 and 2009 Air Force surface wipe data to model personnel exposures and to estimate dioxin body burden for dermal-oral exposure for dried residues using modified generic US Environmental Protection Agency intake algorithms; (2) comparing 1979 Air Force 2,4- dichlorophenoxyacetic acid and 2,4-5-trichlorophenoxyacetic acid air samples to saturated vapor pressure concentrations to estimate potential dioxin exposure through inhalation, ingestion and skin contact with contaminated air and dust; and (3) applying emission models for semivolatile organic compounds from contaminated surfaces to estimate airborne contamination. Model (1): Body-burden estimates for dermal-oral exposure were 0.92 and 5.4pg/kg body-weight-day for flight crew and maintainers. The surface wipe concentrations were nearly two orders of magnitude greater than the US Army guidance level. Model (2): measured airborne concentrations were at least five times greater than saturated vapor pressure, yielding dioxin estimates that ranged from 13.2-27.0pg/m(3), thus

Ethics, jurisprudence, and economics in the medical school curriculum.

PubMed Central

O'Neill, L. C.; Davidson, R. C.; Tupper, C. J.; Scherger, J. E.; Walsh, D. A.

1990-01-01

Medical ethics, medical jurisprudence, and medical economics are recognized as important components of a medical school curriculum. These subjects were introduced through a course given at the University of California, Davis, School of Medicine. Four aspects of the format and content of the course were instrumental to its success. Teaching principles of medical ethics within the context of jurisprudence and economics permitted the students to gain an understanding of the institutions and processes that act as positive and negative constraints on physicians' clinical and professional behavior. The course was offered during the fourth year following required clinical rotations so that all aspects of the course could be based on the clinical experiences of the students. It was presented in a continuing medical education format away from the normal teaching environment of first- and second-year classrooms and third-year clerkships. Finally, the course was designed by a multidisciplinary, multidepartmental planning group that included students. PMID:2260303

Essentials of Literacy: From A Pilot Site at Davis Street School To District-Wide Intervention

ERIC Educational Resources Information Center

Brown, Fay E.; Murray, Edward T.

2005-01-01

Since the mid 1990s, reading instruction has changed and so has the School Development Program's (SDP) Essentials of Literacy (EOL) process. Beginning as a teaching suggestion at one New Haven, Connecticut school, Lincoln Bassett, EOL became a pilot project at Davis Street School in New Haven for the 1996-1997 school year and continues to be an…

Humphrey Davy and the Safety Lamp: The Use of Metal Gauze as a Flame Barrier

ERIC Educational Resources Information Center

Mills, Allan

2015-01-01

The "safety lamp" invented by Humphrey Davy in 1815 utilised the cooling effect of metal gauze to prevent the flame of a candle or oil lamp (essential for illumination in mines) from passing through such a screen. It is therefore rendered unable to ignite any potentially explosive mixture of air and methane in the atmosphere surrounding…

Tightness Entropic Uncertainty Relation in Quantum Markovian-Davies Environment

NASA Astrophysics Data System (ADS)

Zhang, Jun; Liu, Liang; Han, Yan

2018-05-01

In this paper, we investigate the tightness of entropic uncertainty relation in the absence (presence) of the quantum memory which the memory particle being weakly coupled to a decohering Davies-type Markovian environment. The results show that the tightness of the quantum uncertainty relation can be controlled by the energy relaxation time F, the dephasing time G and the rescaled temperature p, the perfect tightness can be arrived by dephasing and energy relaxation satisfying F = 2G and p = 1/2. In addition, the tightness of the memory-assisted entropic uncertainty relation and the entropic uncertainty relation can be influenced mainly by the purity. While in memory-assisted model, the purity and quantum correlation can also influence the tightness actively while the quantum entanglement can influence the tightness slightly.

Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study.

PubMed

Reinisch, Walter; Panés, Julián; Khurana, Sunil; Toth, Gabor; Hua, Fei; Comer, Gail M; Hinz, Michelle; Page, Karen; O'Toole, Margot; Moorehead, Tara McDonnell; Zhu, Hua; Sun, YanHui; Cataldi, Fabio

2015-06-01

Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody that inhibits human IL-13, was evaluated for the treatment of UC. In a multicentre, randomised, double-blind, placebo-controlled study, patients with active UC (Mayo score ≥4 and <10) were randomised to anrukinzumab 200, 400 or 600 mg or placebo. Patients received five intravenous administrations over 14 weeks. The primary endpoint was fold change from baseline in faecal calprotectin (FC) at Week 14. Secondary endpoints included safety, pharmacokinetics and IL-13 levels. The modified intention-to-treat population included 84 patients (21 patients/arm). Fold change of FC from baseline at Week 14 was not significantly different for any treatment groups compared with the placebo. The study had a high dropout rate, in part, related to lack of efficacy. The exploratory comparisons of each dose were not significantly different from placebo in terms of change from baseline in total Mayo score, clinical response, clinical remission and proportion of subjects with mucosal healing. An increase in serum total IL-13 (free and bound to anrukinzumab) was observed for all anrukinzumab groups but not with placebo. This suggests significant binding of anrukinzumab to IL-13. The safety profile was not different between the anrukinzumab and placebo groups. A statistically significant therapeutic effect of anrukinzumab could not be demonstrated in patients with active UC in spite of binding of anrukinzumab to IL-13. ClinicalTrials.gov number NCT01284062. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Placebo Response is Driven by UCS Revaluation: Evidence, Neurophysiological Consequences and a Quantitative Model

PubMed Central

Puviani, Luca; Rama, Sidita

2016-01-01

Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms, theoretical modeling of the placebo response remains poorly developed. The most extensively accepted theories are expectation and conditioning, involving both conscious and unconscious information processing. However, it is not completely understood how these mechanisms can shape the placebo response. We focus here on neural processes which can account for key properties of the response to substance intake. It is shown that placebo response can be conceptualized as a reaction of a distributed neural system within the central nervous system. Such a reaction represents an integrated component of the response to open substance administration (or to substance intake) and is updated through “unconditioned stimulus (UCS) revaluation learning”. The analysis leads to a theorem, which proves the existence of two distinct quantities coded within the brain, these are the expected or prediction outcome and the reactive response. We show that the reactive response is updated automatically by implicit revaluation learning, while the expected outcome can also be modulated through conscious information processing. Conceptualizing the response to substance intake in terms of UCS revaluation learning leads to the theoretical formulation of a potential neuropharmacological treatment for increasing unlimitedly the effectiveness of a given drug. PMID:27436417

Placebo Response is Driven by UCS Revaluation: Evidence, Neurophysiological Consequences and a Quantitative Model.

PubMed

Puviani, Luca; Rama, Sidita

2016-07-20

Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms, theoretical modeling of the placebo response remains poorly developed. The most extensively accepted theories are expectation and conditioning, involving both conscious and unconscious information processing. However, it is not completely understood how these mechanisms can shape the placebo response. We focus here on neural processes which can account for key properties of the response to substance intake. It is shown that placebo response can be conceptualized as a reaction of a distributed neural system within the central nervous system. Such a reaction represents an integrated component of the response to open substance administration (or to substance intake) and is updated through "unconditioned stimulus (UCS) revaluation learning". The analysis leads to a theorem, which proves the existence of two distinct quantities coded within the brain, these are the expected or prediction outcome and the reactive response. We show that the reactive response is updated automatically by implicit revaluation learning, while the expected outcome can also be modulated through conscious information processing. Conceptualizing the response to substance intake in terms of UCS revaluation learning leads to the theoretical formulation of a potential neuropharmacological treatment for increasing unlimitedly the effectiveness of a given drug.

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with "F-5" Gene.

PubMed

Leng, Xiangfeng; Fan, Yongle; Wang, Yating; Sun, Jian; Cai, Xia; Hu, Chunnan; Ding, Xiaoying; Hu, Xiaoying; Chen, Zhengyu

2017-06-06

BACKGROUND Recent studies have shown that skin flap transplantation technique plays an important role in surgical procedures. However, there are many problems in the process of skin flap transplantation surgeries, especially ischemia-reperfusion injury, which directly affects the survival rate of the skin flap and patient prognosis after surgeries. MATERIAL AND METHODS In this study, we used a new method of the "stem cells-gene" combination therapy. The "F-5" gene fragment of heat shock protein 90-α (Hsp90-α) was transfected into human umbilical cord mesenchymal stem cells (hUC-MSCs) by genetic engineering technique. RESULTS The synergistic effects of "F-5" gene and hUC-MSCs in the treatment of ischemia-reperfusion injury of the skin flap were confirmed by histochemical and immunohistochemical methods. CONCLUSIONS This study showed that the hUC-MSCs transfected with "F-5" gene can effectively improve the repair of ischemia-reperfusion injury.

Molecular insight on the non-covalent interactions between carbapenems and uc(l,d)-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study

NASA Astrophysics Data System (ADS)

Ntombela, Thandokuhle; Fakhar, Zeynab; Ibeji, Collins U.; Govender, Thavendran; Maguire, Glenn E. M.; Lamichhane, Gyanu; Kruger, Hendrik G.; Honarparvar, Bahareh

2018-05-01

Tuberculosis remains a dreadful disease that has claimed many human lives worldwide and elimination of the causative agent Mycobacterium tuberculosis also remains elusive. Multidrug-resistant TB is rapidly increasing worldwide; therefore, there is an urgent need for improving the current antibiotics and novel drug targets to successfully curb the TB burden. uc(l,d)-Transpeptidase 2 is an essential protein in Mtb that is responsible for virulence and growth during the chronic stage of the disease. Both uc(d,d)- and uc(l,d)-transpeptidases are inhibited concurrently to eradicate the bacterium. It was recently discovered that classic penicillins only inhibit uc(d,d)-transpeptidases, while uc(l,d)-transpeptidases are blocked by carbapenems. This has contributed to drug resistance and persistence of tuberculosis. Herein, a hybrid two-layered ONIOM (B3LYP/6-31G+(d): AMBER) model was used to extensively investigate the binding interactions of LdtMt2 complexed with four carbapenems (biapenem, imipenem, meropenem, and tebipenem) to ascertain molecular insight of the drug-enzyme complexation event. In the studied complexes, the carbapenems together with catalytic triad active site residues of LdtMt2 (His187, Ser188 and Cys205) were treated at with QM [B3LYP/6-31+G(d)], while the remaining part of the complexes were treated at MM level (AMBER force field). The resulting Gibbs free energy (ΔG), enthalpy (ΔH) and entropy (ΔS) for all complexes showed that the carbapenems exhibit reasonable binding interactions towards LdtMt2. Increasing the number of amino acid residues that form hydrogen bond interactions in the QM layer showed significant impact in binding interaction energy differences and the stabilities of the carbapenems inside the active pocket of LdtMt2. The theoretical binding free energies obtained in this study reflect the same trend of the experimental observations. The electrostatic, hydrogen bonding and Van der Waals interactions between the carbapenems and Ldt

Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA).

PubMed

Bagi, C M; Berryman, E R; Teo, S; Lane, N E

2017-12-01

The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery 10 rats received vehicle and another 10 rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition 10 naïve rats were used as an intact control and another 10 rats received sham surgery. Study endpoints included a weight-bearing capacity of front and hind legs, serum biomarkers of bone and cartilage metabolism, analyses of subchondral and cancellous bone at the tibial epiphysis and metaphysis, and cartilage pathology at the medial tibial plateau using histological methods. PMMT surgery produced moderate OA at the medial tibial plateau. Specifically, the deterioration of articular cartilage negatively impacted the weight bearing capacity of the operated limb. Immediate treatment with the UC-II preserved the weight-bearing capacity of the injured leg, preserved integrity of the cancellous bone at tibial metaphysis and limited the excessive osteophyte formation and deterioration of articular cartilage. Study results demonstrate that a clinically relevant daily dose of UC-II when applied immediately after injury can improve the mechanical function of the injured knee and prevent excessive deterioration of articular cartilage. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

A Campus Handicap? Disabled Students and the Right to Higher Education--Southeastern Community College v Davis.

ERIC Educational Resources Information Center

Hauben, Ronald Bruce

1979-01-01

In the context of an analysis of the Davis case, an expansion of the law regulating rights of the handicapped to higher education is encouraged. Constitutional arguments are applied. The burden of providing reasonable access is placed on institutions. Equal protection and due process arguments may be used as theories of relief. (MSE)

Julian Davies and the discovery of kanamycin resistance transposon Tn5.

PubMed

Berg, Douglas E

2017-04-01

This paper recounts some of my fond memories of a collaboration between Julian Davies and myself that started in 1974 in Geneva and that led to our serendipitous discovery of the bacterial kanamycin resistance transposon Tn5, and aspects of the lasting positive impact of our interaction and discovery on me and the community. Tn5 was one of the first antibiotic resistance transposons to be found. Its analysis over the ensuing decades provided valuable insights into mechanisms and control of transposition, and led to its use as a much-valued tool in diverse areas of molecular genetics, as also will be discussed here.

Improving Blood Monitoring of Enzymes as Biomarkers of Risk from Anticholinergic Pesticides and Chemical Warfare Agents

DTIC Science & Technology

2007-10-01

agent exposure --monitoring blood cholinesterase activity with the Test-mateTM OP Kit. In Technical Bulletin: Assay Techniques for Detection of Exposure ...at CHPPM and by the Ellman method at UC Davis. Second, DFP-treated whole blood was used to mimic OP exposure . RBC AChE activity was measured using... cholinesterase activity in mammalian blood and tissue. Bulletin of Environmental Contamination and Toxicology 77(6):785- 792 Arrieta DE, McCurdy

It is Time to Rescind Don’t Ask, Don’t Tell

DTIC Science & Technology

2009-04-02

cohesion and that in turn would affect accomplishing the mission. A study done at UC, Davis, makes a distinction between social cohesion and task...cohesion.22 Social cohesion is the nature and quality of emotional bonds of friendship, closeness, etc. and task cohesion is a shared commitment among...studies of cohesion and performance it is task cohesion, not social cohesion or group pride that drives group performance. Professor MacCoun also

Recruitment, Advancement and Retention of Women in the Physical Sciences at U.C. Irvine

NASA Astrophysics Data System (ADS)

Druffel, E. R.; Smecker-Hane, T.; Kehoe, P.; Bryant, S. V.

2004-12-01

Strategies for the recruitment, retention and advancement of women in the physical sciences at U.C. Irvine are presented. The NSF-funded ADVANCE Program has implemented several new initiatives. Among these are new requirements for recruitment committees, participation by school equity advisors, personalized mentoring programs and establishment of senior chairs. Progress towards our goals are reviewed and evaluated. Issues such as dual career couples and the balance between family/personal time and work are also addressed.

Entangled de Sitter from stringy axionic Bell pair I: an analysis using Bunch-Davies vacuum

NASA Astrophysics Data System (ADS)

Choudhury, Sayantan; Panda, Sudhakar

2018-01-01

In this work, we study the quantum entanglement and compute entanglement entropy in de Sitter space for a bipartite quantum field theory driven by an axion originating from Type IIB string compactification on a Calabi-Yau three fold (CY^3) and in the presence of an NS5 brane. For this computation, we consider a spherical surface S^2, which divides the spatial slice of de Sitter (dS_4) into exterior and interior sub-regions. We also consider the initial choice of vacuum to be Bunch-Davies state. First we derive the solution of the wave function of the axion in a hyperbolic open chart by constructing a suitable basis for Bunch-Davies vacuum state using Bogoliubov transformation. We then derive the expression for density matrix by tracing over the exterior region. This allows us to compute the entanglement entropy and Rényi entropy in 3+1 dimension. Furthermore, we quantify the UV-finite contribution of the entanglement entropy which contain the physics of long range quantum correlations of our expanding universe. Finally, our analysis complements the necessary condition for generating non-vanishing entanglement entropy in primordial cosmology due to the axion.

UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II

PubMed Central

Lord, Matthew; Pollard, Thomas D.

2004-01-01

We purified native Myo2p/Cdc4p/Rlc1p (Myo2), the myosin-II motor required for cytokinesis by Schizosaccharomyces pombe. The Myo2p heavy chain associates with two light chains, Cdc4p and Rlc1p. Although crude Myo2 supported gliding motility of actin filaments in vitro, purified Myo2 lacked this activity in spite of retaining full Ca-ATPase activity and partial actin-activated Mg-ATPase activity. Unc45-/Cro1p-/She4p-related (UCS) protein Rng3p restored the full motility and actin-activated Mg-ATPase activity of purified Myo2. The COOH-terminal UCS domain of Rng3p alone restored motility to pure Myo2. Thus, Rng3p contributes directly to the motility activity of native Myo2. Consistent with a role in Myo2 activation, Rng3p colocalizes with Myo2p in the cytokinetic contractile ring. The absence of Rlc1p or mutations in the Myo2p head or Rng3p compromise the in vitro motility of Myo2 and explain the defects in cytokinesis associated with some of these mutations. In contrast, Myo2 with certain temperature-sensitive forms of Cdc4p has normal motility, so these mutations compromise other functions of Cdc4p required for cytokinesis. PMID:15504913

Hydrology of Crater, East and Davis Lakes, Oregon; with section on Chemistry of the Lakes

USGS Publications Warehouse

Phillips, Kenneth N.; Van Denburgh, A.S.

1968-01-01

Crater, East, and Davis Lakes are small bodies of fresh water that occupy topographically closed basins in Holocene volcanic terrane. Because the annual water supply exceeds annual evaporation, water must be lost by seepage from each lake. The seepage rates vary widely both in volume and in percentage of the total water supply. Crater Lake loses about 89 cfs (cubic feet per second), equivalent to about 72 percent of its average annual supply. East Lake loses about 2.3 cfs, or about 44 percent of its estimated supply. Davis Lake seepage varies greatly with lake level, but the average loss is about 150 cfs, more than 90 percent of its total supply. The destination of the seepage loss is not definitely known for any of the lakes. An approximate water budget was computed for stationary level for each lake, by using estimates 'by the writer to supplement the hydrologic data available. The three lake waters are dilute. Crater Lake contains about 80 ppm, (parts per million) of dissolved solids---mostly silica, sodium, and bicarbonate, and lesser amounts of calcium, sulfate, and chloride. Much of the dissolved-solids content of Crater Lake---especially the sulfate and chloride---may be related to fumarole and thermal-spring activity that presumably followed the collapse of Mount Mazama. Although Grater Lake loses an estimated 7,000 tons of its 1.5million-ton salt content each year by leakage, the chemical character of the lake did not change appreciably between 1912 and 1964. East Lake contains 200 ppm of dissolved solids, which includes major proportions of calcium, sodium, bicarbonate, and sulfate, but almost no chloride. The lake apparently receives much of its dissolved solids from subsurface thermal springs. Annual solute loss from East Lake by leakage is about 450 tons, or 3 percent of the lake's 15,000-ton estimated solute content. Davis Lake contains only 48 ppm of dissolved solids, much of which is silica and bicarbonate; chloride is almost completely absent

78 FR 13811 - Special Local Regulation; Annual Marine Events on the Colorado River, Between Davis Dam (Bullhead...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-01

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2012-1094] Special Local Regulation; Annual Marine Events on the Colorado River, Between Davis Dam (Bullhead City, AZ) and Headgate Dam (Parker, AZ) Within the San Diego Captain of the Port Zone AGENCY: Coast Guard, DHS. ACTION...

77 FR 67563 - Special Local Regulation; Annual Marine Events on the Colorado River, Between Davis Dam (Bullhead...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-13

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2012-0925] Special Local Regulation; Annual Marine Events on the Colorado River, Between Davis Dam (Bullhead City, AZ) and Headgate Dam (Parker, AZ) Within the San Diego Captain of the Port Zone AGENCY: Coast Guard, DHS. ACTION...

The STEMWiki Hyperlibrary: A Collaborative Multidisciplinary Textbook Environment

NASA Astrophysics Data System (ADS)

Halpern, J. B.

2015-12-01

The STEMWiki Hyperlibrary Project is a collaborative effort directed by Prof. Delmar Larsen of UC Davis to replace printed textbooks with a no-fee, high quality, on line textbook environment for STEM courses and informal education. Instructors can build textbooks for their students by linking modules in the Hyperlibrary, write their own texts or use those built by others. The flexibility of the Hyperlibrary allows instructors to address the needs of diverse students in all types of institutions. At present over 4 million people per month visit the site, which makes it a primary global source of STEM educational material. The seed was the ChemWiki, which is the most developed, but there is also a GeoWiki that is being used for courses on Structural Geology, Sediments and Strata and Oceanography at UC Davis as well as including core components on geochemistry, geophysics, mineralogy, oceanography, paleobiology, paleoenvironments, petrology and plate tectonics. In addition to using and contributing to the GeoWiki, AGU members can participate in the other STEMWikis by writing (or editing) core components that involve geophysical topics and make use of the core components in the other areas for their teaching. The GeoWiki can be accessed at http://geowiki.ucdavis.edu/

Characterizing and Improving Distributed Intrusion Detection Systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurd, Steven A; Proebstel, Elliot P.

2007-11-01

Due to ever-increasing quantities of information traversing networks, network administrators are developing greater reliance upon statistically sampled packet information as the source for their intrusion detection systems (IDS). Our research is aimed at understanding IDS performance when statistical packet sampling is used. Using the Snort IDS and a variety of data sets, we compared IDS results when an entire data set is used to the results when a statistically sampled subset of the data set is used. Generally speaking, IDS performance with statistically sampled information was shown to drop considerably even under fairly high sampling rates (such as 1:5). Characterizingmore » and Improving Distributed Intrusion Detection Systems4AcknowledgementsThe authors wish to extend our gratitude to Matt Bishop and Chen-Nee Chuah of UC Davis for their guidance and support on this work. Our thanks are also extended to Jianning Mai of UC Davis and Tao Ye of Sprint Advanced Technology Labs for their generous assistance.We would also like to acknowledge our dataset sources, CRAWDAD and CAIDA, without which this work would not have been possible. Support for OC48 data collection is provided by DARPA, NSF, DHS, Cisco and CAIDA members.« less

Medical and Economic Impact of a Free Student-Run Podiatric Medical Clinic A Preliminary Analysis.

PubMed

Hua, Natalie T; Shih, Chia-Ding; Tran, David

2015-09-01

Data from the free student-run podiatric medical clinic at Clínica Tepati at the University of California, Davis, were used to analyze medical and economic impacts on health-care delivery and to extrapolate the economic impact to the national level. Clínica Tepati also provides an excellent teaching environment and services to the uninsured Hispanic population in the Greater Sacramento area. In this analysis, we retrospectively reviewed patient medical records for podiatric medical encounters during 15 clinic days between November 2010 and February 2012. The economic impact was evaluated by matching diagnoses and treatments with Medicare reimbursement rates using International Classification of Diseases codes, Current Procedural Terminology codes, and the prevailing Medicare reimbursement rates. Sixty-three podiatric medical patients made 101 visits during this period. Twenty patients returned to the clinic for at least one follow-up visit or for a new medical concern. Thirty-nine different diagnoses were identified, and treatments were provided for all 101 patient encounters/visits. Treatments were limited to those within the clinic's resources. This analysis estimates that $17,332.13 worth of services were rendered during this period. These results suggest that the free student-run podiatric medical clinic at Clínica Tepati had a significant medical and economic impact on the delivery of health care at the regional level, and when extrapolated, nationally as well. These student-run clinics also play an important role in medical education settings.

C. Judson King of UC Berkeley

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prausnitz, John

2005-06-01

In the middle of the UC Berkeley campus, next to the Main Library, South Hall is the last surviving building from the original campus, founded about 135 years ago. A tiny tree-shaded appendix to this venerated classical building houses Berkeley's Center for Studies in Higher Education, directed by C. Judson King, former Provost and Senior Vice President--Academic Affairs of the ten-campus University of California and long-time Professor of Chemical Engineering at Berkeley. Jud came to Berkeley in 1963 as assistant professor of chemical engineering, following receipt of a doctor's degree from MIT and a subsequent short appointment as director ofmore » the MIT chemical engineering practice school station at what was then Esso (now Exxon) in New Jersey. His undergraduate degree is from Yale. Starting with his MIT doctoral dissertation on gas absorption, Jud has devoted much of his professional career to separation processes. His teaching and research activities have been primarily concerned with separation of mixtures with emphasis on liquid-liquid extraction and drying. As a consultant to Procter and Gamble, he contributed to the technology of making instant coffee. His life-long activities in hiking and camping stimulated Jud's interest in the manufacture of freeze-dried foods (e.g. turkey meat) to minimize the weight of his hiking back-pack. Jud is internationally known not only for his many research publications but even more, for his acclaimed textbook ''Separation Processses'' (McGraw-Hill, second edition 1980) that is used in standard chemical engineering courses in the US and abroad.« less

The Politics of Normative Childhoods and Non-Normative Parenting: A Response to Cristyn Davies and Kerry Robinson

ERIC Educational Resources Information Center

Chapman, Amy; Saltmarsh, Sue

2013-01-01

This article offers a consideration of the ways that the politics of normative childhoods are shaped by discourses of happiness predicated on heteronormativity. Responding to the work of Cristyn Davies and Kerry Robinson (2013, this issue), the authors argue that non-normative families and in particular, non-normative parenting, are obliged to…

42 CFR 137.379 - Do Davis-Bacon wage rates apply to construction projects performed by Self-Governance Tribes...

Code of Federal Regulations, 2012 CFR

2012-10-01

... (excluding Indian Tribes, inter-Tribal consortia, and Tribal organizations) retained by Self-Governance... projects performed by Self-Governance Tribes using Federal funds? 137.379 Section 137.379 Public Health... HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Other § 137.379 Do Davis-Bacon wage rates...

42 CFR 137.379 - Do Davis-Bacon wage rates apply to construction projects performed by Self-Governance Tribes...

Code of Federal Regulations, 2013 CFR

2013-10-01

... (excluding Indian Tribes, inter-Tribal consortia, and Tribal organizations) retained by Self-Governance... projects performed by Self-Governance Tribes using Federal funds? 137.379 Section 137.379 Public Health... HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Other § 137.379 Do Davis-Bacon wage rates...

42 CFR 137.379 - Do Davis-Bacon wage rates apply to construction projects performed by Self-Governance Tribes...

Code of Federal Regulations, 2010 CFR

2010-10-01

... (excluding Indian Tribes, inter-Tribal consortia, and Tribal organizations) retained by Self-Governance... projects performed by Self-Governance Tribes using Federal funds? 137.379 Section 137.379 Public Health... HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Other § 137.379 Do Davis-Bacon wage rates...

42 CFR 137.379 - Do Davis-Bacon wage rates apply to construction projects performed by Self-Governance Tribes...

Code of Federal Regulations, 2014 CFR

2014-10-01

... (excluding Indian Tribes, inter-Tribal consortia, and Tribal organizations) retained by Self-Governance... projects performed by Self-Governance Tribes using Federal funds? 137.379 Section 137.379 Public Health... HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Other § 137.379 Do Davis-Bacon wage rates...

42 CFR 137.379 - Do Davis-Bacon wage rates apply to construction projects performed by Self-Governance Tribes...

Code of Federal Regulations, 2011 CFR

2011-10-01

... (excluding Indian Tribes, inter-Tribal consortia, and Tribal organizations) retained by Self-Governance... projects performed by Self-Governance Tribes using Federal funds? 137.379 Section 137.379 Public Health... HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Other § 137.379 Do Davis-Bacon wage rates...

Academic productivity and its relationship to physician salaries in the University of California Healthcare System.

PubMed

Fijalkowski, Natalia; Zheng, Luo Luo; Henderson, Michael T; Moshfeghi, Andrew A; Maltenfort, Mitchell; Moshfeghi, Darius M

2013-07-01

To evaluate whether physicians with higher academic productivity, as measured by the number of publications in Scopus and the Scopus Hirsch index (h-index), earn higher salaries. This was a cross-sectional study. Participants were ophthalmologists, otolaryngologists, neurosurgeons, and neurologists classified as "top earners" (>$100,000 annually) within the University of California (UC) healthcare system in 2008. Bibliometric searches on Scopus were conducted to retrieve the total number of publications and Hirsch indices (h-index), a measure of academic productivity. The association between the number of publications and h-index on physicians' total compensation was determined with multivariate regression models after controlling for the four specialties (ophthalmology, otolaryngology, neurosurgery, and neurology), the five institutions (UC San Francisco, UC Los Angeles, UC San Diego, UC Irvine, and UC Davis), and academic rank (assistant professor, associate professor, and professor). The UC healthcare system departments reported 433 faculty physicians among the four specialties, with 71.6% (n = 310) earning more than $100,000 in 2008 and classifying as top earners. After controlling for the specialty, institution, and ranking, there was a significant association between the number of publications on salary (P < 0.000001). Scopus number of publications and h-index were correlated (P < 0.001). Scopus h-index was of borderline significance in predicting physician salary (P = 0.12). Physicians with higher Scopus publications had higher total salaries across all four specialties. Every 10 publications were associated with a 2.40% increase in total salary after controlling for specialty, institution, rank, and chair. Ophthalmologists, otolaryngologists, neurosurgeons, and neurologists in the UC healthcare system who are more academically productive receive greater remuneration.

The Use of Computer-Based Data Banks in the Teaching of Clinical Problem-Solving and Medical Case Management to Veterinary Students

ERIC Educational Resources Information Center

Conzelman, Gaylord M.; And Others

1975-01-01

Describes a program at the School of Veterinary Medicine, University of California at Davis to give students experience in diagnosis and management of urinary tract diseases. Students request from computer data banks that laboratory information they deem most useful in the medical management of each clinical problem. (JT)

A Randomized Clinical Trial of Allopregnanolone for the Treatment of Severe Traumatic Brain Injury

DTIC Science & Technology

2010-10-01

by four outside reviewers: Kia Shahlaie, M.D., Ph.D. (University of California, San Francisco ), Anne-Marie Guerguerian, M.D. (University of Toronto...of the Pre-IND Package described below and the UC Davis IRB filing. Pre-IND Meeting Information Package and IND. Medkura Pharmaceutical and Camargo ... Camargo a Pre-IND meeting information document was developed which will serve as the basis for the IND filing that will be made after the Pre-IND meeting

The Chicago Public Schools (CPS)/University of Chicago (UC) Internet Project (CUIP)

NASA Astrophysics Data System (ADS)

Richardson, D.; Rebull, L. M.; Munoz-Franco, L.; Jay, M. J.; Burke, R. D.; Fenstermacher, K. D.; Lenz, D. D.; MacNaught, H.; Marks, M. D.; Murphy, J.; Thomas, C.; York, D. G.; Anderson, D.; Chisom, Y.; Dynis, R.; Letts, J.; Lewis, E.; Harris, E.; Segneri, L.

1998-01-01

The Chicago Public Schools (CPS)/University of Chicago (UC) Internet Project (CUIP) is a collaborative pilot project among the UC, CPS Central Administration, and 24 public schools in the Woodlawn, Hyde Park/ South Kenwood, and North Kenwood/Oakland neighborhoods. Our primary goal is connecting these schools to the Internet, emphasizing the continued support of the schools and their teachers after the computers and connections are in place. We work with principals, department heads, and individual teachers to create and nurture a self-sustaining computer culture that will both maintain the network systems and incorporate the technology into the curriculum. We also encourage the schools to take advantage of ther new connectivity by collaborating and sharing resources among themselves. Formal interactions are fostered with museums and research centers, locally and nationally. CUIP is committed to supporting these schools as they use the Internet to enhance student learning. CUIP's goals include: providing T-1 internet connectivity to 24 local schools, supporting the technology coordinator in each school in order to ensure continuous Internet connectivity, and developing effective technology plans, including technology upgrades; nurturing and supporting teachers interested in incorporating technology in their classroom; fostering an environment in which the students can acquire a wide range of comptuer skills appropriate to the current job market; and fostering similar community-based efforts, around Chicago and the nation. CUIP's milestones include: internet service connected to 12 schools; technology interns placed in some CUIP schools in collaboration with Governors State University; email provided to more than half of the 660 teachers in connected schools; and World Wide Web for Teachers, a summer class on curriculum uses of the Web, taught by CUIP staff to 23 of over 100 public school teacher applicants.

33 CFR 165.1124 - Annual Firework Events on the Colorado River, between Davis Dam (Bullhead City, Arizona) and...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Laughlin Tourism Committee. Event Description Fireworks Display Date First week in July. Location Laughlin... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Annual Firework Events on the... § 165.1124 Annual Firework Events on the Colorado River, between Davis Dam (Bullhead City, Arizona) and...

33 CFR 165.1124 - Annual Firework Events on the Colorado River, between Davis Dam (Bullhead City, Arizona) and...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Laughlin Tourism Committee. Event Description Fireworks Display Date First week in July. Location Laughlin... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Annual Firework Events on the... § 165.1124 Annual Firework Events on the Colorado River, between Davis Dam (Bullhead City, Arizona) and...

Singing behavior of fin whales in the Davis Strait with implications for mating, migration and foraging.

PubMed

Simon, Malene; Stafford, Kathleen M; Beedholm, Kristian; Lee, Craig M; Madsen, Peter T

2010-11-01

Most baleen whales undertake migrations between low-latitude breeding grounds and high-latitude feeding grounds. Though little is known about the timing of their migration from the Arctic, fin whales are assumed to undertake a similar migratory pattern. To address questions about habitat use and migrations, the acoustic activity of fin whales in Davis Strait, between Greenland and Canada, was monitored continuously for two years using three bottom-moored acoustic recorders. The acoustic power in the fin whale call frequencies peaked in November-December, showing that fin whales are present in Davis Strait much later in the year than previously expected. The closely timed peaks in song activity and conception time imply that not all fin whales migrate south to mate, but rather start mating at high latitudes rather than or before migrating. Singing activity was strongly linked to daylight hours, suggesting that fin whales might feed during the few daylight hours of the late fall and early Arctic winter. A negative correlation between the advancing sea ice front and power in fin whale frequencies indicates that future changes in sea ice conditions from global warming might change the distribution and migratory patterns of fin whales near the poles.

Downregulation of viral RNA translation by hepatitis C virus non-structural protein NS5A requires the poly(U/UC) sequence in the 3' UTR.

PubMed

Hoffman, Brett; Li, Zhubing; Liu, Qiang

2015-08-01

Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is essential for viral replication; however, its effect on HCV RNA translation remains controversial partially due to the use of reporters lacking the 3' UTR, where NS5A binds to the poly(U/UC) sequence. We investigated the role of NS5A in HCV translation using a monocistronic RNA containing a Renilla luciferase gene flanked by the HCV UTRs. We found that NS5A downregulated viral RNA translation in a dose-dependent manner. This downregulation required both the 5' and 3' UTRs of HCV because substitution of either sequence with the 5' and 3' UTRs of enterovirus 71 or a cap structure at the 5' end eliminated the effects of NS5A on translation. Translation of the HCV genomic RNA was also downregulated by NS5A. The inhibition of HCV translation by NS5A required the poly(U/UC) sequence in the 3' UTR as NS5A did not affect translation when it was deleted. In addition, we showed that, whilst the amphipathic α-helix of NS5A has no effect on viral translation, the three domains of NS5A can inhibit translation independently, also dependent on the presence of the poly(U/UC) sequence in the 3' UTR. These results suggested that NS5A downregulated HCV RNA translation through a mechanism involving the poly(U/UC) sequence in the 3' UTR.

FIFI: The MPE Garching/UC Berkeley Far-Infrared Imaging Fabry-Perot Interferometer

NASA Technical Reports Server (NTRS)

Geis, Norbert; Genzel, Reinhard; Haggerty, M.; Herrmann, F.; Jackson, J.; Madden, Suzanne C.; Nikola, T.; Poglitsch, Albrecht; Rumitz, M.; Stacey, G. J.

1995-01-01

We describe the performance characteristics of the MPE Garching/UC Berkeley Far-Infrared Imaging Fabry-Perot Interferometer (FIFI) for the Kuiper Airborne Observatory (KAO). The spectrometer features two or three cryogenic tunable Fabry-Perot filters in series giving spectral resolution R of up to 10(exp 5) in the range of 40 microns less than lambda less than 200 microns, and an imaging 5x5 array of photoconductive detectors with variable focal plane plate scale. The instrument works at background limited sensitivity of up to 2 x 10(exp -19) W cm(exp -2) Hz(exp -1/2) per pixel per resolution element at R = 10(exp 5) on the KAO.

Geology of the Davis Mesa quadrangle, Colorado

USGS Publications Warehouse

Cater, Fred W.; Bryner, Leonid

1953-01-01

The Davis Mesa quadrangle is one of eighteen 7 1/2-minute quadrangles covering the principal carnotite-producing area of southwestern Colorado. The geology of these quadrangles was mapped by the U.S. Geological Survey for the Atomic Energy Commission as part of a comprehensive study of carnotite deposits. The rocks exposed in the eighteen quadrangles consist of crystalline rocks of pre-Cambrian age and sedimentary rocks that range in age from late Paleozoic to Quaternary. Over much of the area the sedimentary rocks are flat lying, but in places the rocks are disrupted by hih-angle faults, and northwest-trending folds. Conspicuous among the folds are large anticlines having cores of intrusive salt and gypsum. Most of the carnotite deposits are confined to the Salt Wash sandstone member of Jurassic Morrison formation. Within this sandstone, most of the deposits are spottily distributed through an arcuate zone known as "Uruvan Mineral Belt". Individual deposits range in size from irregular masses containing only a few tons of ore to large, tabular masses containing many thousands of tons. The ore consists largely of sandstone selectively impregnated and in part replaced by uranium and vanadium minerals. Most of the deposits appear to be related to certain sedimentary structures in sandstones of favorable composition.

How the Bayesians Got Their Beliefs (and What Those Beliefs Actually Are): Comment on Bowers and Davis (2012)

ERIC Educational Resources Information Center

Griffiths, Thomas L.; Chater, Nick; Norris, Dennis; Pouget, Alexandre

2012-01-01

Bowers and Davis (2012) criticize Bayesian modelers for telling "just so" stories about cognition and neuroscience. Their criticisms are weakened by not giving an accurate characterization of the motivation behind Bayesian modeling or the ways in which Bayesian models are used and by not evaluating this theoretical framework against specific…

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with “F-5” Gene

PubMed Central

Leng, Xiangfeng; Fan, Yongle; Wang, Yating; Sun, Jian; Cai, Xia; Hu, Chunnan; Ding, Xiaoying; Hu, Xiaoying; Chen, Zhenyu

2017-01-01

Background Recent studies have shown that skin flap transplantation technique plays an important role in surgical procedures. However, there are many problems in the process of skin flap transplantation surgeries, especially ischemia-reperfusion injury, which directly affects the survival rate of the skin flap and patient prognosis after surgeries. Material/Methods In this study, we used a new method of the “stem cells-gene” combination therapy. The “F-5” gene fragment of heat shock protein 90-α (Hsp90-α) was transfected into human umbilical cord mesenchymal stem cells (hUC-MSCs) by genetic engineering technique. Results The synergistic effects of “F-5” gene and hUC-MSCs in the treatment of ischemia-reperfusion injury of the skin flap were confirmed by histochemical and immunohistochemical methods. Conclusions This study showed that the hUC-MSCs transfected with “F-5” gene can effectively improve the repair of ischemia-reperfusion injury. PMID:28586321

Observations of the larval stages of Diceroprocta apache Davis (Homoptera: Tibicinidae)

USGS Publications Warehouse

Ellingson, A.R.; Andersen, D.C.; Kondratieff, B.C.

2002-01-01

Diceroprocta apache Davis is a locally abundant cicada in the riparian woodlands of the southwestern United States. While its ecological importance has often been hypothesized, very little is known of its specific life history. This paper presents preliminary information on life history of D. apache from larvae collected in the field at seasonal intervals as well as a smaller number of reared specimens. Morphological development of the fore-femoral comb closely parallels growth through distinct size classes. The data indicate the presence of five larval instars in D. apache. Development times from greenhouse-reared specimens suggest a 3-4 year life span and overlapping broods were present in the field. Sex ratios among pre-emergent larvae suggest the asynchronous emergence of sexes.

Tectonic Structure, Solid Earth and Cryosphere Interactions in the Casey-Davis Region of East Antarctica

NASA Astrophysics Data System (ADS)

Reading, A. M.; King, M. A.; Halpin, J.; Whittaker, J. M.; White, D.; Cook, S.; Staal, T.

2016-12-01

The region of inland East Antarctica between Casey and Davis stations (Wilkes Land to Princess Elizabeth Land) is one of the least investigated parts of the continent with respect to its tectonic and solid Earth structure. This is difficult to estimate because the conjugate margin in plate reconstructions has been lost in the collision between India and Eurasia. The region is also host to some of the greatest uncertainties in Antarctica in glacial-isostatic adjustment observations and models, and where the contribution of heat from underlying rocks is difficult to estimate due to the limited available rock samples. We investigate the solid Earth structure and its interactions with the East Antarctic ice sheet through a new campaign including GPS and seismic instrument deployments, and field measurements to constrain ice retreat history. This presentation provides an overview of the new, multi-year Casey-Davis Glacial Isostatic Adjustment campaign including station locations and deployment progress. The campaign is being supported by Australian Antarctic Division and uses a combination of fixed-wing and helicopter support to access station locations in both coastal locations and the continental interior. A primary long-term objective of the campaign is to remove bias from estimates of East Antarctica's contribution to past and present sea level changes. We also seek to better constrain the geothermal influences on the East Antarctic ice sheet. The GPS determinations of vertical plate motion and the detailed seismic structure await data downloads in future field seasons, however, we are able to present new findings from preliminary studies. We show candidate ancient tectonic reconstructions for this part of East Antarctica and make use of our knowledge of structure of continental regions with a similar evolution to infer the likely structures for the Casey-Davis region. We add these new constraints to the structure currently inferred from a very small number of

Biofilm Formation on Stainless Steel by Streptococcus thermophilus UC8547 in Milk Environments Is Mediated by the Proteinase PrtS.

PubMed

Bassi, D; Cappa, F; Gazzola, S; Orrù, L; Cocconcelli, P S

2017-04-15

In Streptococcus thermophilus , gene transfer events and loss of ancestral traits over the years contribute to its high level of adaptation to milk environments. Biofilm formation capacity, a phenotype that is lost in the majority of strains, plays a role in persistence in dairy environments, such as milk pasteurization and cheese manufacturing plants. To investigate this property, we have studied S. thermophilus UC8547, a fast-acidifying dairy starter culture selected for its high capacity to form biofilm on stainless steel under environmental conditions resembling the dairy environment. Using a dynamic flow cell apparatus, it was shown that S. thermophilus UC8547 biofilm formation on stainless steel depends on the presence of milk proteins. From this strain, which harbors the prtS gene for the cell wall protease and shows an aggregative phenotype, spontaneous mutants with impaired biofilm capacity can be isolated at high frequency. These mutants lack the PrtS expendable island, as confirmed by comparison of the genome sequence of UC8547Δ3 with that of the parent strain. The prtS island excision occurs between two 26-bp direct repeats located in the two copies of the IS Sth1 flanking this genomic island. The central role of PrtS was confirmed by analyzing the derivative strain UC8547Δ16, whose prtS gene was interrupted by an insertional mutation, thereby making it incapable of biofilm formation. PrtS, acting as a binding substance between the milk proteins adhered to stainless steel and S. thermophilus cell envelopes, mediates biofilm formation in dairy environments. This feature provides S. thermophilus with an ecological benefit for its survival and persistence in this environment. IMPORTANCE The increased persistence of S. thermophilus biofilm has consequences in the dairy environment: if, on the one hand, the release of this microorganism from biofilm can promote the fermentation of artisanal cheeses, under industrial conditions it may lead to undesirable

Biofilm Formation on Stainless Steel by Streptococcus thermophilus UC8547 in Milk Environments Is Mediated by the Proteinase PrtS

PubMed Central

Cappa, F.; Gazzola, S.; Orrù, L.

2017-01-01

ABSTRACT In Streptococcus thermophilus, gene transfer events and loss of ancestral traits over the years contribute to its high level of adaptation to milk environments. Biofilm formation capacity, a phenotype that is lost in the majority of strains, plays a role in persistence in dairy environments, such as milk pasteurization and cheese manufacturing plants. To investigate this property, we have studied S. thermophilus UC8547, a fast-acidifying dairy starter culture selected for its high capacity to form biofilm on stainless steel under environmental conditions resembling the dairy environment. Using a dynamic flow cell apparatus, it was shown that S. thermophilus UC8547 biofilm formation on stainless steel depends on the presence of milk proteins. From this strain, which harbors the prtS gene for the cell wall protease and shows an aggregative phenotype, spontaneous mutants with impaired biofilm capacity can be isolated at high frequency. These mutants lack the PrtS expendable island, as confirmed by comparison of the genome sequence of UC8547Δ3 with that of the parent strain. The prtS island excision occurs between two 26-bp direct repeats located in the two copies of the ISSth1 flanking this genomic island. The central role of PrtS was confirmed by analyzing the derivative strain UC8547Δ16, whose prtS gene was interrupted by an insertional mutation, thereby making it incapable of biofilm formation. PrtS, acting as a binding substance between the milk proteins adhered to stainless steel and S. thermophilus cell envelopes, mediates biofilm formation in dairy environments. This feature provides S. thermophilus with an ecological benefit for its survival and persistence in this environment. IMPORTANCE The increased persistence of S. thermophilus biofilm has consequences in the dairy environment: if, on the one hand, the release of this microorganism from biofilm can promote the fermentation of artisanal cheeses, under industrial conditions it may lead to

Training the Translational Research Teams of the Future: UC Davis—HHMI Integrating Medicine into Basic Science Program

PubMed Central

Rainwater, Julie A.; Chiamvimonvat, Nipavan; Bonham, Ann C.; Robbins, John A.; Henderson, Stuart; Meyers, Frederick J.

2013-01-01

Abstract There is a need for successful models of how to recruit, train, and retain bench scientists at the earliest stages of their careers into translational research. One recent, promising model is the University of California Davis Howard Hughes Medical Institute Integrating Medicine into Basic Science (HHMI‐IMBS) program, part of the HHMI Med into Grad initiative. This paper outlines the HHMI‐IMBS program's logic, design, and curriculum that guide the goal of research that moves from bedside to bench. That is, a curriculum that provides graduate students with guided translational training, clinical exposure, team science competencies, and mentors from diverse disciplines that will advance the students careers in clinical translational research and re‐focusing of research to answer clinical dilemmas. The authors have collected data on 55 HHMI‐IMBS students to date. Many of these students are still completing their graduate work. In the current study the authors compare the initial two cohorts (15 students) with a group of 29 control students to examine the program success and outcomes. The data indicate that this training program provides an effective, adaptable model for training future translational researchers. HHMI‐IMBS students showed improved confidence in conducting translational research, greater interest in a future translational career, and higher levels of research productivity and collaborations than a comparable group of predoctoral students. PMID:24127920

77 FR 70121 - Special Local Regulation; Annual Marine Events on the Colorado River Between Davis Dam (Bullhead...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

... Local Regulation; Annual Marine Events on the Colorado River Between Davis Dam (Bullhead City, AZ) and... during the Lake Havasu City Boat Parade of Lights on December 01, 2012 from 5 p.m. to 9 p.m. This event... Lake Havasu City Boat Parade of Lights (Item 10 on Table 1 of 33 CFR 100.1102). The Coast Guard will...

LncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats mediated by P2X7 receptor in SCG.

PubMed

Wu, Bing; Zhang, Chunping; Zou, Lifang; Ma, Yucheng; Huang, Kangyu; Lv, Qiulan; Zhang, Xi; Wang, Shouyu; Xue, Yun; Yi, Zhihua; Jia, Tianyu; Zhao, Shanhong; Liu, Shuangmei; Xu, Hong; Li, Guilin; Liang, Shangdong

2016-05-01

Diabetic autonomic neuropathy includes the sympathetic ganglionic dysfunction. P2X7 receptor in superior cervical ganglia (SCG) participated in the pathological changes of cardiac dysfunction. Abnormal expression of long noncoding RNAs (lncRNAs) was reported to be involved in nervous system diseases. Our preliminary results obtained from rat lncRNA array profiling revealed that the expression of the uc.48+ was significantly increased in the rat SCG in response to diabetic sympathetic pathology. In this study, we found that lncRNAuc.48+ and P2X7 receptor in the SCG were increased in type 2 diabetic rats and were associated with the cardiac dysfunction. The uc.48+ small interference RNA (siRNA) improved the cardiac autonomic dysfunction and decreased the up-regulation P2X7 and the ratio of phosphorylated extracellular regulated protein kinases1/2 (p-ERK1/2) to ERK1/2 in SCG of type 2 diabetic rats. In conclusion, lncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats through regulating the expression of P2X7 and ERK signaling in SCG. Copyright © 2016 Elsevier B.V. All rights reserved.

Former University of California Chancellors Urge New Funding Models for UC. Research & Occasional Paper Series: CSHE.15.11

ERIC Educational Resources Information Center

Center for Studies in Higher Education, 2011

2011-01-01

In this era of massive budget cuts, the survival of the University of California as a great institution of learning has become the subject of increasingly urgent debate. Twenty-two of the twenty-nine living former UC chancellors met in San Francisco on June 26-28, 2011 to discuss the current threats facing the University and all of California…

Application of a quantitative histological health index for Antarctic rock cod (Trematomus bernacchii) from Davis Station, East Antarctica.

PubMed

Corbett, Patricia A; King, Catherine K; Mondon, Julie A

2015-08-01

A quantitative Histological Health Index (HHI) was applied to Antarctic rock cod (Trematomus bernacchii) using gill, liver, spleen, kidney and gonad to assess the impact of wastewater effluent from Davis Station, East Antarctica. A total of 120 fish were collected from 6 sites in the Prydz Bay region of East Antarctica at varying distances from the wastewater outfall. The HHI revealed a greater severity of alteration in fish at the wastewater outfall, which decreased stepwise with distance. Gill and liver displayed the greatest severity of alteration in fish occurring in close proximity to the wastewater outfall, showing severe and pronounced alteration respectively. Findings of the HHI add to a growing weight of evidence indicating that the current level of wastewater treatment at Davis Station is insufficient to prevent impact to the surrounding environment. The HHI for T. bernacchii developed in this study is recommended as a useful risk assessment tool for assessing in situ, sub-lethal impacts from station-derived contamination in coastal regions throughout Antarctica. Copyright © 2015 Elsevier Ltd. All rights reserved.

STS-47 MS Davis and Pilot Brown monitor ISAIAH on OV-105's middeck

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Mission Specialist (MS) N. Jan Davis (left) and Pilot Curtis L. Brown, Jr, monitor the Israel Space Agency Investigation About Hornets (ISAIAH) on the middeck of Endeavour, Orbiter Vehicle (OV) 105. ISAIAH, an enclosure located in locker MF43H, contains 180 female Oriental Hornets and will examine the effects of microgravity on the orientation, reproductive capability and social activity of the hornets. Also, the direction of comb-building by hornet workers in microgravity, as well as the structural integrity of the combs, will be examined.

Paleocene Picrites of Davis Strait: Products of a Plume or Plates?

NASA Astrophysics Data System (ADS)

Beutel, E. K.; Clarke, D. B.

2017-12-01

Voluminous, subaerial, ultra-depleted, 62 Ma, primary picritic lavas occur on both sides of Davis Strait separating Baffin Island and West Greenland. Temporally, the picrites are coeval with the initiation of sea-floor spreading in Labrador Sea and Baffin Bay around 62 Ma. Petrogenetically, the chemical characteristics of these picrites (MgO = 18-21 wt. %; K2O = 0.01-0.20 wt. %; 87Sr/86Sri ≈ 0.7030; ɛNdi ≈ +5.2-8.6; 3He/4He ≤ 49.5RA) demand only derivation by partial melting of highly depleted subcontinental lithospheric mantle (SCLM) at a pressure of 4 GPa, followed by rapid ascent to the surface, but do not necessarily require high temperatures or high degrees of partial melting. Tectonically, these picrites formed in thick Archean and Paleoproterozoic cratonic terranes during Paleogene rifting between Greenland and North America. Structurally, the picrites are related to the major intersection of a NNW suture zone under Baffin Bay and the E-W trending Paleoproterozoic Nagssugtoqidian Fold Belt. During the late Mesozoic, ENE extension created normal faulted basins quasi-parallel with the NNW suture and thinned the mantle lithosphere. Elastic finite element models and present day studies of crustal extension show that the thicker Nagssugtoqidian Fold Belt underwent less thinning and extension than the NNW suture zone in the Archean Rae craton. These extensional disparities occur at the orthogonal intersection of pre-existing E-W trending strike-slip faults in the thicker Nagssugtoqidian Fold Belt with the NNW thinned Archean suture zone, and likely resulted in the formation of one or more pull-apart basins. Because the strike-slip faults are ancient suture zones, trans-tension within these suture zones easily reached 120 km, creating not only decompression melting in the SCLM, but also a pathway for the picritic melts to rapidly reach the surface. Such a purely tectonic model requires no spatially or temporally improbable deep mantle plume for generation of

VLT near- to mid-IR imaging and spectroscopy of the M 17 UC1 - IRS5 region

NASA Astrophysics Data System (ADS)

Chen, Zhiwei; Nürnberger, Dieter E. A.; Chini, Rolf; Jiang, Zhibo; Fang, Min

2015-06-01

Aims: We investigate the surroundings of the hypercompact H ii region M 17 UC1 to probe the physical properties of the associated young stellar objects and the environment of massive star formation. Methods: We use diffraction-limited near-IR (VLT/NACO) and mid-IR (VLT/VISIR) images to reveal the different morphologies at various wavelengths. Likewise, we investigate the stellar and nebular content of the region with VLT/SINFONI integral field spectroscopy with a resolution R ˜ 1500 at H + K bands. Results: Five of the seven point sources in this region show L-band excess emission. A geometric match is found between the H2 emission and near-IR polarized light in the vicinity of IRS5A, and between the diffuse mid-IR emission and near-IR polarization north of UC1. The H2 emission is typical for dense photodissociation regions (PDRs), which are initially far-ultraviolet pumped and repopulated by collisional de-excitation. The spectral types of IRS5A and B273A are B3-B7 V/III and G4-G5 III, respectively. The observed infrared luminosity LIR in the range 1-20 μm is derived for three objects; we obtain 2.0 × 103 L⊙ for IRS5A, 13 L⊙ for IRS5C, and 10 L⊙ for B273A. Conclusions: IRS5 might be a young quadruple system. Its primary star IRS5A is confirmed to be a high-mass protostellar object (˜9 M⊙, ˜1 × 105 yrs); it might have terminated accretion due to the feedback from stellar activities (radiation pressure, outflow) and the expanding H ii region of M 17. The object UC1 might also have terminated accretion because of the expanding hypercompact H ii region, which it ionizes. The disk clearing process of the low-mass young stellar objects in this region might be accelerated by the expanding H ii region. The outflows driven by UC1 are running south-north with its northeastern side suppressed by the expanding ionization front of M 17; the blue-shifted outflow lobe of IRS5A is seen in two types of tracers along the same line of sight in the form of H2 emission

Pre-diagnostic Clinical Presentations and Medical History Prior to the Diagnosis of Inflammatory Bowel Disease in Children.

PubMed

Kwon, Yong Hoon; Kim, Yong Joo

2013-09-01

The clinical presentations of inflammatory bowel disease (IBD) prior to diagnosis are so diverse or vague that many of them waste time before final diagnosis. This study was undertaken to know the medical history of the pediatric patients until the final diagnosis could be reached. The medical records of all pediatric patients who were diagnosed with IBD (Crohn's disease [CD] in 14 children, ulcerative colitis [UC] in 17) during the last 13 years were reviewed. We investigated the length of the diagnostic time lag, chief clinical presentation, and any useful laboratory predictor among the routinely performed examinations. Indeterminate colitis was not included. The mean ages of children at the final diagnosis was similar in both diseases. As for the pre-clinical past history of bowel symptoms in CD patients, 5 were previously healthy, 9 had had 1-3 gastrointestinal (GI) symptoms, weight loss, bloody stool, anemia and rectal prolapse. With UC, 9 were previously healthy, 8 had had 1-3 GI symptoms, bloody stool, anorexia. The average diagnostic time lag with CD was 3.36 months, and with UC 2.2 months. Body mass index (BMI) and the initial basic laboratory data (white blood cell, hemoglobin, mean corpuscular volume, serum albumin, and serum total protein) were lower in CD, statistically significant only in BMI. IBD shows diverse clinical symptoms before its classical features, making the patients waste time until diagnosis. It is important to concern possibility of IBD even in the mildly sick children who do not show the characteristic symptoms of IBD.

Improving outcomes for patients with medication-resistant anxiety: effects of collaborative care with cognitive behavioral therapy.

PubMed

Campbell-Sills, Laura; Roy-Byrne, Peter P; Craske, Michelle G; Bystritsky, Alexander; Sullivan, Greer; Stein, Murray B

2016-12-01

Many patients with anxiety disorders remain symptomatic after receiving evidence-based treatment, yet research on treatment-resistant anxiety is limited. We evaluated effects of cognitive behavioral therapy (CBT) on outcomes of patients with medication-resistant anxiety disorders using data from the Coordinated Anxiety Learning and Management (CALM) trial. Primary care patients who met study entry criteria (including DSM-IV diagnosis of generalized anxiety disorder, panic disorder, posttraumatic stress disorder, or social anxiety disorder) despite ongoing pharmacotherapy of appropriate type, dose, and duration were classified as medication resistant (n = 227). Logistic regression was used to estimate effects of CALM's CBT program (CALM-CBT; chosen by 104 of 117 medication-resistant patients randomized to CALM) versus usual care (UC; n = 110) on response [≥ 50% reduction of 12-item Brief Symptom Inventory (BSI-12) anxiety and somatic symptom score] and remission (BSI-12 < 6) at 6, 12, and 18 months. Within-group analyses examined outcomes by treatment choice (CBT vs. CBT plus medication management) and CBT dose. Approximately 58% of medication-resistant CALM-CBT patients responded and 46% remitted during the study. Relative to UC, CALM-CBT was associated with greater response at 6 months (AOR = 3.78, 95% CI 2.02-7.07) and 12 months (AOR = 2.49, 95% CI 1.36-4.58) and remission at 6, 12, and 18 months (AORs = 2.44 to 3.18). Patients in CBT plus medication management fared no better than those in CBT only. Some evidence suggested higher CBT dose produced better outcomes. CBT can improve outcomes for patients whose anxiety symptoms are resistant to standard pharmacotherapy. © 2016 Wiley Periodicals, Inc.

Basement and crustal structure of the Davis Sea region (East Antarctica): implications for tectonic setting and continent to oceanic boundary definition

USGS Publications Warehouse

Guseva, Y.B.; Leitchenkov, G.L.; Gandyukhin, V.V.; Ivanov, S.V.

2007-01-01

This study is based on about 8400 km of MCS, magnetic and gravity data as well as 20 sonobuoys collected by the Russian Antarctic Expedition during 2003 and 2004 in the Davis Sea and adjacent areas between 80°E and 102°E. Major tectonic provinces and features are identified and mapped in the study region including: 1) A marginal rift with a the extended continental crust ranging 130 to more than 200 km in width; 2) The marginal volcanic plateau of the Bruce Bank consisting of the Early Cretaceous igneous rocks; 3) The Early Cretaceous and Late Cretaceous−Paleogene oceanic basins; and 4) The Early Cretaceous igneous province of the Kerguelen Plateau. Four major horizons identified in the sedimentary cover of the Davis Sea region are attributed to main tectonic events and/or paleoenvironmental changes.

Evaluation of optimal water fluoridation on the incidence and skeletal distribution of naturally arising osteosarcoma in pet dogs

PubMed Central

Rebhun, R. B.; Kass, P. H.; Kent, M. S.; Watson, K. D.; Withers, S. S.; Culp, W. T. N.; King, A.M.

2016-01-01

Experimental toxicological studies in laboratory animals and epidemiological human studies have reported a possible association between water fluoridation and osteosarcoma (OSA). To further explore this possibility, a case-control study of individual dogs evaluated by the UC Davis Veterinary Medical Teaching Hospital was conducted using ecologic data on water fluoridation based on the owner’s residence. The case group included 161 dogs with OSA diagnosed between 2008–2012. Two cancer control groups included dogs diagnosed with lymphoma (LSA) or hemangiosarcoma (HSA) during the same period (n = 134 and n = 145, respectively). Dogs with OSA were not significantly more likely to live in an area with optimized fluoride in the water than dogs with LSA or HSA. Additional analyses within OSA patients also revealed no significant differences in age, or skeletal distribution of OSA cases relative to fluoride status. Taken together, these analyses do not support the hypothesis that optimal fluoridation of drinking water contributes to naturally occurring OSA in dogs. PMID:26762869

Evaluation of optimal water fluoridation on the incidence and skeletal distribution of naturally arising osteosarcoma in pet dogs.

PubMed

Rebhun, R B; Kass, P H; Kent, M S; Watson, K D; Withers, S S; Culp, W T N; King, A M

2017-06-01

Experimental toxicological studies in laboratory animals and epidemiological human studies have reported a possible association between water fluoridation and osteosarcoma (OSA). To further explore this possibility, a case-control study of individual dogs evaluated by the UC Davis Veterinary Medical Teaching Hospital was conducted using ecologic data on water fluoridation based on the owner's residence. The case group included 161 dogs with OSA diagnosed between 2008-2012. Two cancer control groups included dogs diagnosed with lymphoma (LSA) or hemangiosarcoma (HSA) during the same period (n = 134 and n = 145, respectively). Dogs with OSA were not significantly more likely to live in an area with optimized fluoride in the water than dogs with LSA or HSA. Additional analyses within OSA patients also revealed no significant differences in age, or skeletal distribution of OSA cases relative to fluoride status. Taken together, these analyses do not support the hypothesis that optimal fluoridation of drinking water contributes to naturally occurring OSA in dogs. © 2016 John Wiley & Sons Ltd.

Medical students' attitudes toward gay men.

PubMed

Matharu, Kabir; Kravitz, Richard L; McMahon, Graham T; Wilson, Machelle D; Fitzgerald, Faith T

2012-08-08

Healthcare providers' attitudes toward sexual minorities influence patient comfort and outcomes. This study characterized medical student attitudes toward gay men, focusing on behavior, personhood, gay civil rights, and male toughness. A cross-sectional web-based anonymous survey was sent to medical students enrolled at the University of California, Davis (N = 371) with a response rate of 68%. Few respondents expressed negative attitudes toward gay men or would deny them civil rights. More negative responses were seen with respect to aspects of intimate behavior and homosexuality as a natural form of sexual expression. Men and students younger than 25 years old were more likely to endorse negative attitudes toward behavior as well as more traditional views on male toughness. We show that an important minority of students express discomfort with the behavior of gay men and hold to a narrow construction of male identity. These findings suggest that competency training must move beyond conceptual discussions and address attitudes toward behaviors through new pedagogical approaches.

Development of telescope control system for the 50cm telescope of UC Observatory Santa Martina

NASA Astrophysics Data System (ADS)

Shen, Tzu-Chiang; Soto, Ruben; Reveco, Johnny; Vanzi, Leonardo; Fernández, Jose M.; Escarate, Pedro; Suc, Vincent

2012-09-01

The main telescope of the UC Observatory Santa Martina is a 50cm optical telescope donated by ESO to Pontificia Universidad Catolica de Chile. During the past years the telescope has been refurbished and used as the main facility for testing and validating new instruments under construction by the center of Astro-Engineering UC. As part of this work, the need to develop a more efficient and flexible control system arises. The new distributed control system has been developed on top of Internet Communication Engine (ICE), a framework developed by Zeroc Inc. This framework features a lightweight but powerful and flexible inter-process communication infrastructure and provides binding to classic and modern programming languages, such as, C/C++, java, c#, ruby-rail, objective c, etc. The result of this work shows ICE as a real alternative for CORBA and other de-facto distribute programming framework. Classical control software architecture has been chosen and comprises an observation control system (OCS), the orchestrator of the observation, which controls the telescope control system (TCS), and detector control system (DCS). The real-time control and monitoring system is deployed and running over ARM based single board computers. Other features such as logging and configuration services have been developed as well. Inter-operation with other main astronomical control frameworks are foreseen in order achieve a smooth integration of instruments when they will be integrated in the main observatories in the north of Chile

Remedial Investigation/Feasibility Study (RI/FS) Report, Davis Global Communications Site. Volume 3

DTIC Science & Technology

1994-02-23

ESCP! PrO ~f, Hard, light Olive brown to Oliv Drown (2 a~ , t, sil dry. grosses and rootlets presert r ~Hard. dark bofwn (lOYR 4/3) cjoyey SiT, cry F... CON ,1NUOUS CORING PROJECT NO.: 409717 CUENT: HAZWRAP LOCATION: McCLELLAN AIR FORCE BASE L!J - DAVIS, CA | BORING NO. SBB-23 ’• F/ • j- - - o L Fm G...FFT§,77.,...".. . ...P ?E. ATIE :bEt; IT,ý IR1L_’T < • nOR CONS !STENCY. SO)L STRUtCTURE. i-" ..LL 6" -6" -6" ’ -T S S = ; ’•: .. . . Cl- X - L- N

Tackling the Transition to UC: To Implement Unified Communications on Campus, It Often Pays to Take a Phased Approach

ERIC Educational Resources Information Center

Ramaswami, Rama

2011-01-01

In this article, the author talks about the challenges faced by two schools that lie, coincidentally, just 110 miles apart in the vast spaces of North Dakota. Both schools, members of the North Dakota University System, decided to forge ahead with a unified communications (UC) implementation. And while their final solutions differ, how the two…

The Doctoring Curriculum at the University of California, Davis School of Medicine: Leadership and Participant Roles for Psychiatry Faculty

ERIC Educational Resources Information Center

Bourgeois, James A.; Ton, Hendry; Onate, John; McCarthy, Tracy; Stevenson, Frazier T.; Servis, Mark E.; Wilkes, Michael S.

2008-01-01

Objective: The authors describe in detail the 3-year model of the Doctoring curriculum plus an elective fourth-year Doctoring course at University of California, Davis School of Medicine (UCDSOM) and University of California, Los Angeles (UCLA) School of Medicine and the critical role for psychiatry faculty leadership and participation. Methods:…

Art By Don Davis Artist's concept of one of the probes on the hot surface of Venus. Although the

NASA Technical Reports Server (NTRS)

1977-01-01

Art By Don Davis Artist's concept of one of the probes on the hot surface of Venus. Although the probes were not designed to withstand impact, there was a chance that one might survive and transmit some data from the surface. A small probe did survive and transmitted data for 67 minutes.

Characterization of UC781-Tenofovir Combination Gel Products for HIV-1 Infection Prevention in an Ex Vivo Ectocervical Model

PubMed Central

Cost, Marilyn; Dezzutti, Charlene S.; Clark, Meredith R.; Friend, David R.; Akil, Ayman

2012-01-01

HIV continues to be a problem worldwide. Topical vaginal microbicides represent one option being evaluated to stop the spread of HIV. With drug candidates that have a specific action against HIV now being studied, it is important that, when appropriate and based on the mechanism of action, the drug permeates the tissue so that it can be delivered to specific targets which reside there. Novel formulations of the nucleotide reverse transcriptase inhibitor tenofovir (TFV) and the nonnucleoside reverse transcriptase inhibitor UC781 have been developed and evaluated here. Gels with three distinct rheological properties were prepared. The three gels released both UC781 and TFV under in vitro conditions at concentrations equal to or above the reported 50% effective concentrations (EC50s). The drug concentrations in ectocervical tissues were well in excess of the reported EC50s. The gels maintain ectocervical viability and prevent infection of ectocervical explants after a HIV-1 challenge. This study successfully demonstrates the feasibility of using this novel combination of antiretroviral agents in an aqueous gel as an HIV infection preventative. PMID:22430977

The role of unstable NH3 in the formation of nitrogen-rich alpha-U2N(3+x) by the reaction of UC or U with NH3

NASA Astrophysics Data System (ADS)

Katsura, Masahiro; Hirota, Masayuki; Miyake, Masanobu

1994-10-01

Reactions of U or UC with a stream of NH3 or N2 were carried out at 600 and 900 C. It has been found that in high temperature reactions of U or UC with flowing NH3, the catalytic decomposition of NH3 proceeds in parallel with the nitridation reaction of U or UC by action of NH3, which leads to the formation alpha-U2N(3+x), and eventually a steady state is established where the partial pressures of NH3, H2 and N2 (PNH3, PH2, and PN2) in the flowing gas and the N:U ratio of alpha-U2N(3+x) are all uniquely determined. The nitrogen activity a(sub N) of the flowing gas may be increased by suppressing the decomposition of NH3 into H2 and N2. The N:U ratio of alpha-U2N(3+x) increases as the extent of dissociation of NH3, alpha, decreases.

STS-47 MS Davis uses SLJ Rack 8 continuous heating furnace (CHF) on OV-105

NASA Image and Video Library

1992-09-20

STS047-02-003 (12 - 20 Sept 1992) --- Astronaut N. Jan Davis, mission specialist, works at the Continuous Heating Furnace (CHF) in the Spacelab-J Science Module. This furnace provided temperatures up to 1,300 degrees Celsius and rapid cooling to two sets of samples concurrently. The furnace accommodated in-space experiments in the Fabrication of Si-As-Te:Ni Ternary Amorphous Semiconductor and the Crystal Growth of Compound Semiconductors. These were two of the many experiments designed and monitored by Japan's National Space Development Agency (NASDA).

Infrared spectra and quantum chemical calculations of the uranium-carbon molecules UC, CUC, UCH, and U(CC)2

NASA Astrophysics Data System (ADS)

Wang, Xuefeng; Andrews, Lester; Ma, Dongxia; Gagliardi, Laura; Gonçalves, António P.; Pereira, Cláudia C. L.; Marçalo, Joaquim; Godart, Claude; Villeroy, Benjamin

2011-06-01

Laser evaporation of carbon rich uranium/carbon alloy targets into condensing argon or neon matrix samples gives weak infrared absorptions that increase on annealing, which can be assigned to new uranium carbon bearing species. New bands at 827.6 cm-1 in solid argon or 871.7 cm-1 in neon become doublets with mixed carbon 12 and 13 isotopes and exhibit the 1.0381 carbon isotopic frequency ratio for the UC diatomic molecule. Another new band at 891.4 cm-1 in argon gives a three-band mixed isotopic spectrum with the 1.0366 carbon isotopic frequency ratio, which is characteristic of the anti-symmetric stretching vibration of a linear CUC molecule. No evidence was found for the lower energy cyclic U(CC) isomer. Other bands at 798.6 and 544.0 cm-1 are identified as UCH, which has a uranium-carbon triple bond similar to that in UC. Evidence is found for bicyclic U(CC)2 and tricyclic U(CC)3. This work shows that U and C atoms react spontaneously to form the uranium carbide U≡C and C≡U≡C molecules with uranium-carbon triple bonds.

Ground-water quality in the Davie Landfill, Broward County, Florida

USGS Publications Warehouse

Mattraw, H.C.

1976-01-01

Ground-water adjacent to a disposal pond for septic tank sludge, oil, and grease at the Davie landfill, Broward County, Florida was tested for a variety of ground-water contaminants. Three wells adjacent to the disposal pond yielded water rich in nutrients, organic carbon and many other chemical constituents. Total coliform bacteria ranged from less than 100 to 660 colonies per 100 milliliters in samples collected from the shallowest well (depth 20 feet). At well depths of 35 and 45 feet bacterial counts were less than 20 colonies per 100 milliliters or zero. Concentrations of several constituents in water samples collected from the wells downgradient from the landfill, disposal pond, and an incinerator wash pond were greater than in samples collected from wells immediately upgradient of the landfill. A comparison of sodium-chloride ion ratios indicated that downgradient ground-water contamination was related to the incinerator wash water pond rather than the septic tank sludge pond. (Woodard-USGS)

STS-47 MS Davis and Pilot Brown monitor ISAIAH on OV-105's middeck

NASA Image and Video Library

1992-09-20

STS047-02-018 (12 - 20 Sept 1992) --- Astronauts N. Jan Davis, mission specialist, and Curtis L. Brown, Jr., pilot, oversee the progress of some of the 180 female Oriental Hornets onboard the Space Shuttle Endeavour. The insects are part of the Israeli Space Agency Investigation About Hornets (ISAIAH) experiment. The objective of this experiment is to examine the effects of microgravity on the orientation, reproductive capability and social activity of the hornets. Also, the direction of comb-building by hornet workers in microgravity, as well as the structural integrity of the combs, will be examined.

STS-47 MS Davis and Pilot Brown repair ISAIAH humidity problem aboard OV-105

NASA Image and Video Library

1992-09-20

STS047-35-022 (12 - 20 Sept 1992) --- Astronauts Curtis L. Brown, Jr., pilot, and N. Jan Davis, mission specialist, team up to cure a high humidity problem in the hornet experiment in the Spacelab-J Science Module of the Earth-orbiting Space Shuttle Endeavour. Via a jury-rigged hose hook-up, the two were able to blow air from a spacesuit fan into the experiment, thus eliminating condensation that obscured the viewing of the Israeli hornet experiment. The experiment examined the effects of microgravity on the orientation, reproductive capability and social activity of 180 female Oriental Hornets.

Risk management in obstetric care for family physicians: results of a 10-year project.

PubMed

Nesbitt, Thomas S; Hixon, Allen; Tanji, Jeffrey L; Scherger, Joseph E; Abbott, Dana

2003-01-01

Malpractice issues within the United States remain a critical factor for family physicians providing obstetric care. Although tort reform is being widely discussed, little has been written regarding the malpractice crisis from a risk management perspective. Between 1989 and 1998, a 10-year risk management study at the UC Davis Health System provided a unique collaboration between researchers, a mutual insurance carrier and family physicians practicing obstetrics. Physicians were asked to comply with standardized clinical guidelines, attend continuing medical education (CME) seminars, and submit obstetric medical records for review. Feedback analysis was provided to each physician on their records, and the insurance carrier tracked interim malpractice claims. One hundred and ninety-four physicians participated, attending to 32,831 births. Compliance with project guidelines was 91%. Five closed obstetric cases were reported with only one settlement reported to the National Provider Data Bank. Physicians believed the project was beneficial to their practices. Family physicians practicing obstetrics are willing to participate in a collaborative risk management program and are compliant with standardized clinical guidelines. The monetary award for successful malpractice claims was relatively low. This collaborative risk management model may offer a potential solution to the current malpractice crisis.

"Our sickness record is a national disgrace": Adelle Davis, nutritional determinism, and the anxious 1970s.

PubMed

Carstairs, Catherine

2014-07-01

America's most widely read nutritionist of the postwar decades, Adelle Davis, helped to shape Americans' eating habits, their child-feeding practices, their views about the quality of their food supply, and their beliefs about the impact of nutrition on their emotional and physical health. This paper closely examines Davis's writings and argues that even though she is often associated with countercultural food reformers like Alice Waters and Frances Moore Lappé, she had as much in common with the writings of interwar nutritionists and home economists. While she was alarmed about the impact of pesticides and food additives on the quality of the food supply, and concerned about the declining fertility of American soil, she commanded American women to feed their families better and promised that improved nutrition would produce stronger, healthier, more beautiful children who would ensure America's future strength. She believed that nearly every health problem could be solved through nutrition, and urged her readers to manage their diets carefully and to take extensive supplementation to ensure optimum health. As such, she played an important role in creating the ideology of "nutritionism" - the idea that food should be valued more for its constituent parts than for its pleasures or cultural significance. © The Author 2012. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Genetic conservation, characterization and utilization of wild relatives of fruit and nut crops at the USDA Germplasm Repository in Davis, California

USDA-ARS?s Scientific Manuscript database

The National Clonal Germplasm Repository (NCGR) in Davis is one among the nine repositories in the National Plant Germplasm System, USDA-ARS that is responsible for conservation of clonally propagated woody perennial subtropical and temperate fruit and nut crop germplasm. Currently the repository ho...

Muon flux Measurements at the Davis Campus of the Sanford Underground Research Facility with the Majorana Demonstrator Veto System

DOE PAGES

Abgrall, N.; Aguayo, E.; Avignone, F. T.; ...

2017-02-16

Here, we report the first measurement of the total muon flux underground at the Davis Campus of the Sanford Underground Research Facility at the 4850 ft level. Measurements were performed using the MajoranaDemonstratormuon veto system arranged in two different configurations. The measured total flux is (5.31±0.17)× 10–9μ/s/cm 2.

Reflections on 19th-Century Experience with Knowledge Diffusion: The Sixth Annual Howard Davis Memorial Lecture, April 11, 1991.

ERIC Educational Resources Information Center

Weiss, Carol H.

1991-01-01

Provides the text of the Howard Davis Memorial Lecture, which was presented to the Knowledge Utilization Society in 1991. The lecture describes the work of the Society for the Diffusion of Useful Knowledge, which was active in Great Britain the nineteenth century and compares it with current practices in the field of knowledge utilization. (12…

Muon flux Measurements at the Davis Campus of the Sanford Underground Research Facility with the Majorana Demonstrator Veto System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abgrall, N.; Aguayo, E.; Avignone, F. T.

Here, we report the first measurement of the total muon flux underground at the Davis Campus of the Sanford Underground Research Facility at the 4850 ft level. Measurements were performed using the MajoranaDemonstratormuon veto system arranged in two different configurations. The measured total flux is (5.31±0.17)× 10–9μ/s/cm 2.

Department of the Army Supply Bulletin, Army Medical Department Supply Information, SB8-75-S9

DTIC Science & Technology

2001-09-20

Poisoning (5th Ed./1988) Kaye, S. C. C. Thomas Pubs. $121.95 1 Biochemistry Urinalysis & Body Fluids (3rd Ed./1994) Strasinger, Susan King F. A. Davis Co...35.95 1 Biochemistry Clinical Toxicology of Commercial Products: Acute Poisoning [Replaced by Medical Toxicology] Gosselin, R. E. Williams...LABORATORY PORTABLE 7610-00-782-3912 B47529 B-22 Section/Branch Title Of Book Author Publisher Price Quantity Herpetology Poisonous Snakes Of The

New Standards for Peer Sexual Harassment in the Schools: Title IX Liability Under "Davis v. Monroe County Board of Education."

ERIC Educational Resources Information Center

McClain, Michael W.

1999-01-01

Analyzes the state of the law regarding peer sexual harassment. In "Davis" the Supreme Court ruled that a school district can be held liable for a student's sexual harassment of another student. Prior to this, lower courts were not uniform in their treatment of this charge. (Contains 47 references.) (MLF)

Fractionation of radioactivity in the milk of goats administered UC-aflatoxin B1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goto, T.; Hsieh, D.P.

A detailed fractionation of radioactivity in the milk of goats administered UC-aflatoxin B1 at low doses was performed. The milk collected in the first 24 h following dosing contained radioactivity equivalent to 0.45-1.1% of the dose given. The radioactivity in each sample was partitioned into 4 fractions: ether, protein, dichloromethane, and water-alcohol. Over 80% of the radioactivity was detected in the dichloromethane fraction, of which over 95% was attributable to aflatoxin M1. No aflatoxin B1 or other known aflatoxin metabolites were detected in any fraction. The results indicate that the major metabolite of aflatoxin B1 in goat milk is aflatoxinmore » M1 and that other metabolites, including conjugates, are of minor significance.« less

Ancient Earth, Alien Earths Event

NASA Image and Video Library

2014-08-20

Dr. Dawn Sumner, Professor of Geology, UC Davis, speaks on a panel at the “Ancient Earth, Alien Earths” Event at NASA Headquarters in Washington, DC Wednesday, August 20, 2014. The event was sponsored by NASA, the National Science Foundation (NSF), and the Smithsonian Institution and was moderated by Dr. David H. Grinspoon, Senior Scientist at the Planetary Science Institute. Six scientists discussed how research on early Earth could help guide our search for habitable planets orbiting other stars. Photo Credit: (NASA/Aubrey Gemignani)

Innovative Soft-Sided Waste Packaging System Implementation at a Small Department of Energy Environmental Restoration/Waste Management (ER/WM) Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolf, J.

2002-02-28

Weiss Associates (WA) performs a broad range of environmental restoration/waste management (ER/WM) activities for the U.S. Department of Energy (DOE) at the former Laboratory for Energy-Related Health Research (LEHR), University of California, Davis (UC Davis). Over the last three years, the LEHR ER/WM program transitioned from a baseline packaging system of steel, 2.7 cubic meter (3.5-cubic yard) B-25 boxes to a 7.0 cubic meter (9.1-cubic yard) soft-sided container (Lift Liner) system. The transition increased efficiencies in processing, packaging, and storage, and when combined with decreased procurement costs, achieved a $402,000 cost savings (Table I). Additional disposal costs between $128,600 andmore » $182,600 were avoided by minimizing void space. Future cost savings by the end of fiscal year 2003 are projected between $250,640 and $1,003,360.« less

Medical students’ attitudes toward gay men

PubMed Central

2012-01-01

Background Healthcare providers’ attitudes toward sexual minorities influence patient comfort and outcomes. This study characterized medical student attitudes toward gay men, focusing on behavior, personhood, gay civil rights, and male toughness. Methods A cross-sectional web-based anonymous survey was sent to medical students enrolled at the University of California, Davis (N = 371) with a response rate of 68%. Results Few respondents expressed negative attitudes toward gay men or would deny them civil rights. More negative responses were seen with respect to aspects of intimate behavior and homosexuality as a natural form of sexual expression. Men and students younger than 25 years old were more likely to endorse negative attitudes toward behavior as well as more traditional views on male toughness. Conclusions We show that an important minority of students express discomfort with the behavior of gay men and hold to a narrow construction of male identity. These findings suggest that competency training must move beyond conceptual discussions and address attitudes toward behaviors through new pedagogical approaches. PMID:22873668

Shut out of the System: As Competition Increases for Slots at UC-Berkeley, Admission Offers to Minority Students Continue to Decline

ERIC Educational Resources Information Center

Burdman, Pamela

2004-01-01

As University of California officials announced admissions results for the fall, it appeared that increasing competition for seats at the university, rising tuition costs, and continued controversy over the role of race in admissions were conspiring to reduce the slots offered to African American students at UC-Berkeley. At the same time, the…

The cost of postgraduate medical education and continuing medical education: re-examining the status fifty years back.

PubMed

Walsh, Kieran

2015-03-01

The subject of the cost and value of medical education is becoming increasingly important. However, this subject is not a new one. Fifty years ago, Mr. DH Patey, Dr. OF Davies, and Dr. John Ellis published a report on the state of postgraduate medical education in the UK. The report was wide-ranging, but it made a considerable mention of cost. In this short article, I have presented the documentary research that I conducted on their report. I have analyzed it from a positivist perspective and have concentrated on the subject of cost, as it appears in their report. The authors describe reforms within postgraduate medical education; however, they are clear from the start that the issue of cost can often be a barrier to such reforms. They state the need for basic facilities for medical education, but then outline the financial barriers to their development. The authors then discuss the costs of library services for education. They state that the "annual spending on libraries varies considerably throughout the country." The authors also describe the educational experiences of newly graduated doctors. According to them, the main problem is that these doctors do not have time to attend formal educational events, and that this will not be possible until there is "a more graduated approach to responsible clinical work," something which is not possible without financial investment. While concluding their report, the authors state that the limited money invested in postgraduate medical education and continuing medical education has been well spent, and that this has had a dual effect on improving medical education as well as the standards of medical care.

The Cost of Postgraduate Medical Education and Continuing Medical Education: Re-Examining the Status Fifty Years Back

PubMed Central

2015-01-01

The subject of the cost and value of medical education is becoming increasingly important. However, this subject is not a new one. Fifty years ago, Mr. DH Patey, Dr. OF Davies, and Dr. John Ellis published a report on the state of postgraduate medical education in the UK. The report was wide-ranging, but it made a considerable mention of cost. In this short article, I have presented the documentary research that I conducted on their report. I have analyzed it from a positivist perspective and have concentrated on the subject of cost, as it appears in their report. The authors describe reforms within postgraduate medical education; however, they are clear from the start that the issue of cost can often be a barrier to such reforms. They state the need for basic facilities for medical education, but then outline the financial barriers to their development. The authors then discuss the costs of library services for education. They state that the "annual spending on libraries varies considerably throughout the country." The authors also describe the educational experiences of newly graduated doctors. According to them, the main problem is that these doctors do not have time to attend formal educational events, and that this will not be possible until there is "a more graduated approach to responsible clinical work," something which is not possible without financial investment. While concluding their report, the authors state that the limited money invested in postgraduate medical education and continuing medical education has been well spent, and that this has had a dual effect on improving medical education as well as the standards of medical care. PMID:25802685

CAMPARE and Cal-Bridge: Two Institutional Networks Increasing Diversity in Astronomy

NASA Astrophysics Data System (ADS)

Rudolph, Alexander L.; Smecker-Hane, Tammy A.

2017-01-01

We describe two programs, CAMPARE and Cal-Bridge, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, creating a national impact on their numbers successfully pursuing a PhD in the field.In 7 years, the CAMPARE program has sent 80 students, >80% from underrepresented groups, to conduct summer research at one of 14 major research institutions throughout the country. The graduation rate among CAMPARE scholars is 98%, and of the CAMPARE scholars who have graduated with a Bachelor’s degree, more than 60% have completed or are pursuing graduate education in astronomy or a related field, at institutions including UCLA, UC Riverside, UC Irvine, UC Santa Barbara, USC, Stanford, Univ. of Arizona, Univ. of Washington, and the Fisk-Vanderbilt Master’s-to-PhD program.Now entering its third year, the Cal-Bridge program is a CSU-UC Bridge program comprised of over 75 physics and astronomy faculty from 5 University of California (UC), 9 California State University (CSU), and 14 California Community College (CCC) campuses in Southern California. In the first three years, 22 Cal-Bridge Scholars have been selected, including 11 Hispanic, 3 African-American and 8 female students, 5 of whom are from URM groups. Nineteen (19) of the 22 Cal-Bridge Scholars are first-generation college students. The entire first cohort of 4 Cal-Bridge scholars was accepted to one or more PhD programs in astronomy or physics, including UC Irvine, UC Santa Cruz, UC Davis, Michigan State, and Georgia State Universities. The second cohort of 8 Cal-Bridge scholars is applying to graduate schools this fall.Cal-Bridge provides much deeper mentoring and professional development experiences over the last two years of undergraduate and first year of graduate school to students from this diverse network of higher

Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.

PubMed

Gomez-Escalante, Susana; Piper, Peter W; Millson, Stefan H

2017-01-01

Folding of the myosin head often requires the joint actions of Hsp90 and a dedicated UNC45, Cro1, She4 (UCS) domain-containing cochaperone protein. Relatively weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS proteins of higher organisms (the general cell and smooth muscle UNC45s; UNC45-GC and UNC45-SM respectively). In vertebrates, UNC45-GC facilitates cytoskeletal function whereas the 55% identical UNC45-SM assists in the assembly of the contractile apparatus of cardiac and skeletal muscles. UNC45-SM, unlike UNC45-GC, shares with yeast She4 an IDSL sequence motif known to be a site of in vivo serine phosphorylation in yeast. Investigating this further, we found that both a non-phosphorylatable (S18A) and a phosphomimetic (S18E) mutant form of She4 could rescue the type 1 myosin localisation and endocytosis defects of the yeast she4Δ mutant at 39 °C. Nevertheless, at higher temperature (45 °C), only She4 (S18A), not She4(S18E), could substantially rescue the cell lysis defect of she4Δ mutant cells. In the yeast two-hybrid system, the non-phosphorylatable S18A and S251A mutant forms of She4 and UNC45-SM still displayed the stress-enhanced in vivo interaction with Hsp90 seen with the wild-type She4 and UNC45-SM. Such high-temperature enforcement to interaction was though lost with the phosphomimetic mutant forms (She4(S18E) and UNC45-SM (S251E)), an indication that phosphorylation might suppress these increases in She4/Hsp90 and UNC45-SM/Hsp90 interaction with stress.

The impact of empathy on burnout in medical students: new findings.

PubMed

von Harscher, Heidi; Desmarais, Nathaly; Dollinger, Robert; Grossman, Seth; Aldana, Scarlett

2018-03-01

Research on medical students has shown they are at a higher risk for burnout and that this burnout may become more prevalent as they advance in medical school. The literature, thus far, has not explored the construct of ,emotional empathy and whether this can impact burnout in medical students. Objective: To understand the relationship  between empathy (Empathic Concern [EC] and Personal Distress [PD]) and burnout in medical students. Five successive classes of medical students enrolled at a new medical school were given the Maslach Burnout Inventory and Davis' Interpersonal Reactivity Index  over the course of three successive  years (n = 353).  Two dimensions of  empathy were evaluated to determine if they have an impact on three dimensions of burnout (Emotional Exhaustion/EE, Depersonalization/DP, Personal Accomplishment/PA). data was analyzed using a linear mixed model for each of the three components of burnout based on gender, age, year in medical school, and two types of empathy: EC, and PD.  Conclusion: It was discovered that students with high levels of EC had statistically lower scores of burnout over time while students with high levels of PD empathy showed statistically higher scores of burnout over three years. Implications for these findings are discussed.

Alcohol use in an academic medical school environment: A UC San Diego Healer Education Assessment and Referral (HEAR) Report.

PubMed

Martinez, Stephanie; Tal, Ilanit; Norcross, William; Newton, Isabel Gala; Downs, Nancy; Seay, Kathryn; McGuire, Tara; Kirby, Brittany; Chidley, Brittany; Tiamson-Kassab, Maria; Lee, Daniel; Hadley, Allison; Doran, Neal; Jong, Pam; Lee, Kelly; Moutier, Christine; Norman, Marc; Zisook, Sidney

2016-05-01

Medical students and physicians in training and in practice are at risk for excessive alcohol use and abuse, potentially impacting the affected individuals as well as their family members, trainees, and patients. However, several roadblocks to care, including stigma, often keep them from seeking treatment. We analyzed data from anonymous questionnaires completed by medical students, house staff, and faculty from 2009 to 2014 as part of a depression awareness and suicide prevention program at a state-supported medical school in the United States. The authors explored associations between self-reported "drinking too much" and depression, suicidal ideation, substance use, intense affective states, and mental health treatment. Approximately one-fifth of the respondents reported "drinking too much." "Drinking too much" was associated with more severe depression and impairment, past suicide attempts and current suicidal ideation, intense affective states, and other substance use. Those who were "drinking too much" were more likely than others to accept referrals for mental health treatment through the anonymous interactive screening program, suggesting that this program may be effective in skirting the stigma barrier for accessing mental health care for this at-risk population. The self-reported prevalence of "drinking too much" among medical students, house staff, and faculty is high and associated with negative mental health outcomes. Targeted, anonymous screenings may identify at-risk individuals and provide mental health care referrals to those in need.

Structural and optical characterization of NaGdF{sub 4}: Ho{sup 3+}/Yb{sup 3+} UC nano-particles for lateral finger mark detections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, A., E-mail: ak.phy87@gmail.com; Tiwari, S. P.; Krishna, K. M.

2016-05-23

Ho{sup 3+}/Yb{sup 3+} co-doped NaGdF{sub 4} up-conversion (UC) nano-particles were synthesized by thermal decomposition method. X-ray diffraction and FE-SEM image analysis were done to confirm the structure, morphology and determination of particle size. The UC emission spectra for as prepared as well as 100°C, 200°C, 300°C, 400°C, 800°C, 1000°C and 1200°C heated for 3h samples were recorded and there emission intensities were compared at a constant pump power of excitations 98.1 W/cm{sup 2}. The effect of emission intensity on decay time was also studied through focused and unfocused excitations. The synthesized material was successfully utilized in lateral finger mark detections onmore » the glass substrate through powder dusting method.« less

International variation in medication prescription rates among elderly patients with inflammatory bowel disease.

PubMed

Benchimol, Eric I; Cook, Suzanne F; Erichsen, Rune; Long, Millie D; Bernstein, Charles N; Wong, Jenna; Carroll, Charlotte F; Frøslev, Trine; Sampson, Tim; Kappelman, Michael D

2013-12-01

The elderly represent a growing demographic of patients with IBD. No study has previously described variations in care or medication prescriptions in senior patients with IBD. We compared prescription rates among elderly patients with IBD in four countries using health administrative data. Databases from the United States (US), United Kingdom (UK), Denmark and Canada were queried. Variation in prescription rates between countries was assessed in patients ≥65y with prevalent IBD who had ≥1 prescription for an IBD-related medication in a given quarter between 2004 and 2009. Patients were identified using previously-reported, validated algorithms. Country-specific rates were compared in each quarter using Fisher's exact test. In patients with Crohn's disease, Canada and US had higher prescription rates for oral 5-ASA (P<0.0001 in all quarters) and infliximab (P<0.05 in 22/24 quarters), while the US had higher rates of thiopurine usage (P<0.05 in 23/24 quarters). Canada had greater rates of methotrexate prescriptions (P<0.05 in 21/24 quarters analyzed). In patients with ulcerative colitis (UC), rates of oral steroid usage was lowest in the US (P<0.05 in 22/24 quarters) and oral 5-ASA use was highest in the US and Canada (P<0.0001 in all quarters). Canada and Denmark used more rectal therapy than the US. Infliximab usage in UC was significantly higher in the US and Canada after 2006. Significant variation in medication prescription rates exists among countries. Future research should assess whether these differences were associated with disparities in outcomes and health care costs. Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

Crew Configuration, Ingress/Egress Procedures, and In-Flight Caregiving Capacity in a Space Ambulance Based on the Boeing X-37B

NASA Astrophysics Data System (ADS)

Halberg, Ephriam Etan

This study proposes that a Boeing X-37B space plane, its dimensions and performance characteristics estimated from publicly available documents, diagrams, and photographs, could be internally redesigned as a medical evacuation (ambulance) vehicle for the International Space Station. As of 2017, there is currently no spacecraft designed to accommodate a contingency medical evacuation wherein a crew member aboard the ISS is injured or ailing and must be returned to Earth for immediate medical attention. The X-37B is an unmanned vehicle with a history of success in both sub-orbital testing and all four of its long-duration orbital missions to date. Research conducted at UC Davis suggests that it is possible to retain the outer mold line of the X-37B while expanding the internal payload compartment to a volume sufficient for a crew of three--pilot, crew medical officer, and injured crew member--throughout ISS un-dock and atmospheric entry, descent, and landing. In addition to crew life support systems, this re-purposed X-37B, hereafter referred to as the X-37SA (Space Ambulance), includes medical equipment for stabilization of a patient in-transit. This study suggests an optimal, ergonomic crew configuration and berthing port location, procedures for microgravity ingress and 1G egress, a minimum medical equipment list and location within the crew cabin for the medical care and monitoring equipment. Conceptual crew configuration, ingress/egress procedures, and patient/equipment access are validated via physical simulation in a full-scale mockup of the proposed X-37SA crew cabin.

A new Fortran 90 program to compute regular and irregular associated Legendre functions (new version announcement)

NASA Astrophysics Data System (ADS)

Schneider, Barry I.; Segura, Javier; Gil, Amparo; Guan, Xiaoxu; Bartschat, Klaus

2018-04-01

This is a revised and updated version of a modern Fortran 90 code to compute the regular Plm (x) and irregular Qlm (x) associated Legendre functions for all x ∈(- 1 , + 1) (on the cut) and | x | > 1 and integer degree (l) and order (m). The necessity to revise the code comes as a consequence of some comments of Prof. James Bremer of the UC//Davis Mathematics Department, who discovered that there were errors in the code for large integer degree and order for the normalized regular Legendre functions on the cut.

Evaluation of off-type grasses in hybrid bermudagrass (Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy) putting greens using genotyping-by-sequencing

USDA-ARS?s Scientific Manuscript database

Use of hybrid ultradwarf bermudagrasses (UDBG; Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy) on golf course putting greens is increasing in the southern United States. However, off-type grasses within many putting surfaces have been observed. To explore the genetic variation among UD...

Examination of UC-ZrC after long term irradiation at thermionic temperature

NASA Technical Reports Server (NTRS)

Yang, L.; Johnson, H. O.

1972-01-01

Two fluoride tungsten clad UC-ZrC fueled capsules, designated as V-2C and V-2D, were examined a hot cell after irradiation in NASA Plum Brook Reactor at a maximum cladding temperature of 1930 K for 11,089 and 12,031 hours to burnups of 3.0 x 10 to the 20th power and 2.1 x 10 to the 20th power fission/c.c. respectively. Percentage of fission gas release from the fuel material was measured by radiochemical means. Cladding deformation, fuel-cladding interaction and microstructures of fuel, cladding, and fuel-cladding interface were studied metallographically. Compositions of dispersions in fuel, fuel matrix and fuel-cladding interaction layer were analyzed by electron microprobe techniques. Axial and radial distributions of burnup were determined by gamma-scan, autoradiography and isotopic burnup analysis. The results are presented and discussed in conjunction with the requirements of thermionic fuel elements for space power application.

Clinical and economic outcomes in a population-based European cohort of 948 ulcerative colitis and Crohn's disease patients by Markov analysis.

PubMed

Odes, S; Vardi, H; Friger, M; Esser, D; Wolters, F; Moum, B; Waters, H; Elkjaer, M; Bernklev, T; Tsianos, E; O'Morain, C; Stockbrügger, R; Munkholm, P; Langholz, E

2010-04-01

Forecasting clinical and economic outcomes in ulcerative colitis (UC) and Crohn's disease (CD) patients is complex, but necessary. To determine: the frequency of treatment-classified clinical states; the probability of transition between states; and the economic outcomes. Newly diagnosed UC and CD patients, allocated into seven clinical states by medical and surgical treatments recorded in serial 3-month cycles, underwent Markov analysis. Over 10 years, 630 UC and 318 CD patients had 22,823 and 11,871 cycles. The most frequent clinical outcomes were medical/surgical remission (medication-free) and mild disease (on 5-aminosalicylates, antibiotics, topical corticosteroids), comprising 28% and 62% of UC cycles and 24% and 51% of CD cycles respectively. The probability of drug-response in patients receiving systemic corticosteroids/immunomodulators was 0.74 in UC, 0.66 in CD. Both diseases had similar likelihood of persistent drug-dependency or drug-refractoriness. Surgery was more probable in CD, 0.20, than UC, 0.08. In terms of economic outcomes, surgery was costlier in UC per cycle, but the outlay over 10 years was greater in CD. Drug-refractory UC and CD cases engendered high costs in the cohort. Most patients on 5-aminosalicylates, corticosteroids and immunomodulators had favourable clinical and economic outcomes over 10 years. Drug-refractory and surgical patients exhibited greater long-term expenses.

'Don't play the butter notes': jazz in medical education.

PubMed

Bradner, Melissa; Harper, Darryl V; Ryan, Mark H; Vanderbilt, Allison A

2016-01-01

Jazz has influenced world music and culture globally - attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing - his sound was routine. Miles Davis told him in a low husky murmur, 'Don't play the butter notes'. In medical education, 'don't play the butter notes' suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years.

Translational nutrition research at UC-Davis – the key role of the clinical and translational science center

USDA-ARS?s Scientific Manuscript database

To better understand the facility and equipment needs for human clinical nutrition research the New York Academy of Sciences presented a symposium. This paper is the result of that symposium and provides information into how clinical nutrition research is conducted at the Clinical and Translational ...

Ulcerative Colitis: Update on Medical Management.

PubMed

Iskandar, Heba N; Dhere, Tanvi; Farraye, Francis A

2015-11-01

Ulcerative colitis (UC) is a chronic inflammatory bowel disease whose pathogenesis is multifactorial and includes influences from genes, the environment, and the gut microbiome. Recent advances in diagnosis and treatment have led to significant improvement in managing the disease. Disease monitoring with the use of therapeutic drug monitoring, stool markers, and assessment of mucosal healing have garnered much attention. The recent approval of vedolizumab for treatment of moderate to severe UC has been a welcome addition. Newer biologics, including those targeting the Janus tyrosine kinase (JAK) pathway, are on the horizon to add to the current armamentarium of anti-TNF alpha and anti-integrin therapies. The recent publication of the SCENIC consensus statement on surveillance and management of dysplasia in UC patients supports the use of chromoendoscopy over random biopsies in detecting dysplasia. This review highlights these recent advances along with others that have been made with ulcerative colitis.

Professional charges not reimbursed to dentists in the U.S.: evidence from Medical Expenditure Panel Survey, 1996.

PubMed

Chattopadhyay, A; Slade, G D; Caplan, D J

2009-12-01

This cross-sectional study examined professional charges not paid to dentists. This analysis used logistic regression in SUDAAN examining the 1996 MEPS data from 12,931 adults. Among people incurring dental care charges, 13.6% had more than $50 of unpaid charge (UC). The percapita UC was $53.30. Total UC was higher for highest income group [45.4% of total] compared to lowest income group [26.0%]. The percapita UC of $76.70 for low income group was significantly greater than for high income group ($47.80, P < 0.01). More Medicaid recipients (52% vs. non-recipients: 12%) incurred at least $50 in UC (P < 0.01). Adjusted odds of incurring UC were greater for those employed (OR = 1.3, 95% CI: 1.0-1.7), and for those with private insurance (OR: 1.5, CI: 1.3-1.9). Number of dental procedure types modified the association between Medicaid recipient and UC (OR = 13.6 for Medicaid recipients undergoing multiple procedure types; OR: 2.3 for Medicaid non-recipients with multiple procedure types; OR: 1.9 for Medicaid recipients receiving single dental procedure. Having private insurance, being unemployed and being Medicaid insured undergoing multiple procedure were strongest predictors of UC.

MO-DE-206-00: Joint AAPM-WMIS Symposium: Metabolic Imaging of Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis). Simon’s work on a new whole-body PET imaging system promises to have dramatic improvement in our abilitymore » to detect and characterize cancer using PET. Finally, Jim Bankson (MD Anderson) will discuss extremely sophisticated approaches to quantifying hyperpolarized-13-C pyruvate metabolism using MR imaging. This technology promises to compliment the exquisite sensitivity of PET with an ability to measure not just uptake, but tumor metabolism. Learning Objectives: Understand the metabolism of FDG at a cellular level. Appreciate the engineering related to a novel new high-sensitivity whole-body PET imaging system. Understand the process of hyperpolarization, how pyruvate relates to metabolism and how advanced modeling can be used to better quantify this data. G. Pratx, Funding: 5R01CA186275, 1R21CA193001, and Damon Runyon Cancer Foundation. S. Cherry, National Institutes of Health; University of California, Davis; Siemens Medical SolutionsJ. Bankson, GE Healthcare; NCI P30-CA016672; CPRIT PR140021-P5.« less

MO-DE-206-01: Cellular Metabolism of FDG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pratx, G.

In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis). Simon’s work on a new whole-body PET imaging system promises to have dramatic improvement in our abilitymore » to detect and characterize cancer using PET. Finally, Jim Bankson (MD Anderson) will discuss extremely sophisticated approaches to quantifying hyperpolarized-13-C pyruvate metabolism using MR imaging. This technology promises to compliment the exquisite sensitivity of PET with an ability to measure not just uptake, but tumor metabolism. Learning Objectives: Understand the metabolism of FDG at a cellular level. Appreciate the engineering related to a novel new high-sensitivity whole-body PET imaging system. Understand the process of hyperpolarization, how pyruvate relates to metabolism and how advanced modeling can be used to better quantify this data. G. Pratx, Funding: 5R01CA186275, 1R21CA193001, and Damon Runyon Cancer Foundation. S. Cherry, National Institutes of Health; University of California, Davis; Siemens Medical SolutionsJ. Bankson, GE Healthcare; NCI P30-CA016672; CPRIT PR140021-P5.« less

MO-DE-206-03: Quantifying Metabolism with Hyperpolarized MR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bankson, J.

In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis). Simon’s work on a new whole-body PET imaging system promises to have dramatic improvement in our abilitymore » to detect and characterize cancer using PET. Finally, Jim Bankson (MD Anderson) will discuss extremely sophisticated approaches to quantifying hyperpolarized-13-C pyruvate metabolism using MR imaging. This technology promises to compliment the exquisite sensitivity of PET with an ability to measure not just uptake, but tumor metabolism. Learning Objectives: Understand the metabolism of FDG at a cellular level. Appreciate the engineering related to a novel new high-sensitivity whole-body PET imaging system. Understand the process of hyperpolarization, how pyruvate relates to metabolism and how advanced modeling can be used to better quantify this data. G. Pratx, Funding: 5R01CA186275, 1R21CA193001, and Damon Runyon Cancer Foundation. S. Cherry, National Institutes of Health; University of California, Davis; Siemens Medical SolutionsJ. Bankson, GE Healthcare; NCI P30-CA016672; CPRIT PR140021-P5.« less

MO-DE-206-02: Cellular Metabolism of FDG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cherry, S.

In this symposium jointly sponsored by the World Molecular Imaging Society (WMIS) and the AAPM, luminary speakers on imaging metabolism will discuss three impactful topics. The first presentation on Cellular Metabolism of FDG will be given by Guillem Pratx (Stanford). This presentation will detail new work on looking at how the most common molecular imaging agent, fluoro-deoxy-glucose is metabolized at a cellular level. This will be followed by a talk on an improved approach to whole-body PET imaging by Simon Cherry (UC Davis). Simon’s work on a new whole-body PET imaging system promises to have dramatic improvement in our abilitymore » to detect and characterize cancer using PET. Finally, Jim Bankson (MD Anderson) will discuss extremely sophisticated approaches to quantifying hyperpolarized-13-C pyruvate metabolism using MR imaging. This technology promises to compliment the exquisite sensitivity of PET with an ability to measure not just uptake, but tumor metabolism. Learning Objectives: Understand the metabolism of FDG at a cellular level. Appreciate the engineering related to a novel new high-sensitivity whole-body PET imaging system. Understand the process of hyperpolarization, how pyruvate relates to metabolism and how advanced modeling can be used to better quantify this data. G. Pratx, Funding: 5R01CA186275, 1R21CA193001, and Damon Runyon Cancer Foundation. S. Cherry, National Institutes of Health; University of California, Davis; Siemens Medical SolutionsJ. Bankson, GE Healthcare; NCI P30-CA016672; CPRIT PR140021-P5.« less

The ability of winter grazing to reduce wildfire size, intensity, and fire-induced plant mortality was not demonstrated: A comment on Davies et al. (2015)

EPA Science Inventory

A recent study by Davies et al. sought to test whether winter grazing could reduce wildfire size, fire behavior metrics, and fire-induced plant mortality in shrub-grasslands. The authors concluded that ungrazed rangelands may experience more fire-induced mortality of native peren...

Supreme Court of the United States. Southeastern Community College v. Davis. Certiorari to the United States Court of Appeals for the Fourth Circuit.

ERIC Educational Resources Information Center

Supreme Court of the U. S., Washington, DC.

A suit was brought by Frances B. Davis against Southeastern Community College, which had denied her admission to its nursing program because of her serious hearing disability. (An audiologist's report indicated that she cannot understand speech directed to her except by lipreading.) She alleged that this denial constituted a violation of section…

The HRSC on Mars Express: Mert Davies' Involvement in a Novel Planetary Cartography Experiment

NASA Astrophysics Data System (ADS)

Oberst, J.; Waehlisch, M.; Giese, B.; Scholten, F.; Hoffmann, H.; Jaumann, R.; Neukum, G.

2002-12-01

Mert Davies was a team member of the HRSC (High Resolution Stereo Camera) imaging experiment (PI: Gerhard Neukum) on ESA's Mars Express mission. This pushbroom camera is equipped with 9 forward- and backward-looking CCD lines, 5184 samples each, mounted in parallel, perpendicular to the spacecraft velocity vector. Flight image data with resolutions of up to 10m/pix (from an altitude of 250 km) will be acquired line by line as the spacecraft moves. This acquisition strategy will result in 9 separate almost completely overlapping image strips, each of them having more than 27,000 image lines, typically. [HRSC is also equipped with a superresolution channel for imaging of selected targets at up to 2.3 m/pixel]. The combined operation of the nadir and off-nadir CCD lines (+18.9°, 0°, -18.9°) gives HRSC a triple-stereo capability for precision mapping of surface topography and for modelling of spacecraft orbit- and camera pointing errors. The goals of the camera are to obtain accurate control point networks, Digital Elevation Models (DEMs) in Mars-fixed coordinates, and color orthoimages at global (100% of the surface will be covered with resolutions better than 30m/pixel) and local scales. With his long experience in all aspects of planetary geodesy and cartography, Mert Davies was involved in the preparations of this novel Mars imaging experiment which included: (a) development of a ground data system for the analysis of triple-stereo images, (b) camera testing during airborne imaging campaigns, (c) re-analysis of the Mars control point network, and generation of global topographic orthoimage maps on the basis of MOC images and MOLA data, (d) definition of the quadrangle scheme for a new topographic image map series 1:200K, (e) simulation of synthetic HRSC imaging sequences and their photogrammetric analysis. Mars Express is scheduled for launch in May of 2003. We miss Mert very much!

STS-47 MS Davis and Pilot Brown repair ISAIAH humidity problem aboard OV-105

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Pilot Curtis L. Brown, Jr (foreground) and Mission Specialist (MS) N. Jan Davis (left) team up to cure a high humidity problem in the Israel Space Agency Investigation About Hornets (ISAIAH) experiment on the middeck of Endeavour, Orbiter Vehicle (OV) 105. Via a jury-rigged hose hook-up, the two were able to blow air from a launch and entry suit (LES) fan into the experiment, thus eliminating condesation that obscured the viewing of ISAIAH. ISAIAH, an enclosure located in locker MF43H, contains 180 female Oriental Hornets and will examine the effects of microgravity on the orientation, reproductive capability and social activity of the hornets. Also, the direction of comb-building by hornet workers in microgravity, as well as the structural integrity of the combs, will be examined.

The ability of winter grazing to reduce wildfire size, intensity, and fire-induced plant mortality was not demonstrated: a comment on Davies et al. (2015)

USDA-ARS?s Scientific Manuscript database

A recent study by Davies et al. sought to test whether winter grazing could reduce wildfire size, fire behavior and intensity metrics, and fire-induced plant mortality in shrub-grasslands. The authors concluded that ungrazed rangelands may experience fire-induced mortality of native perennial bunchg...

The dorsal posterior insula is not an island in pain but subserves a fundamental role - Response to: “Evidence against pain specificity in the dorsal posterior insula” by Davis et al.

PubMed Central

Segerdahl, Andrew R.; Mezue, Melvin; Okell, Thomas W.; Farrar, John T.; Tracey, Irene

2015-01-01

An interesting and valuable discussion has arisen from our recent article (Segerdahl, Mezue et al., 2015) and we are pleased here to have the opportunity to expand on the various points we made. Equally important, we wish to correct several important misunderstandings that were made by Davis and colleagues that possibly contributed to their concerns about power when assessing our paper (e.g. actual subject numbers used in control experiment and the reality of the signal-to-noise and sampling of the multi-TI technique we employed). Here, we clarify the methods and analysis plus discuss how we interpret the data in the Brief Communication noting that the extrapolation and inferences made by Davis and colleagues are not consistent with our report or necessarily, in our opinion, what the data supports. We trust this reassures the F1000Research readership regarding the robustness of our results and what we actually concluded in the paper regarding their possible meaning. We are pleased, though, that Davis and colleagues have used our article to raise an important discussion around pain perception, and here offer some further insights towards that broader discussion. PMID:26834997

It Is My Desire to Be Free: Annie Davis's Letter to Abraham Lincoln and Winslow Homer's Painting "A Visit from the Old Mistress"

ERIC Educational Resources Information Center

Hussey, Michael; Eder, Elizabeth K.

2010-01-01

"Mr. President, It is my Desire to be free," wrote Annie Davis to Abraham Lincoln, 20 months after he issued the Emancipation Proclamation. The Emancipation Proclamation affected only those parts of the country that were in rebellion against the United States on the date it was issued, January 1, 1863. The slaveholding border states of…

The Expenditures for Academic Inpatient Care of Inflammatory Bowel Disease Patients Are Almost Double Compared with Average Academic Gastroenterology and Hepatology Cases and Not Fully Recovered by Diagnosis-Related Group (DRG) Proceeds.

PubMed

Baumgart, Daniel C; le Claire, Marie

2016-01-01

Crohn's disease (CD) and ulcerative colitis (UC) challenge economies worldwide. Detailed health economic data of DRG based academic inpatient care for inflammatory bowel disease (IBD) patients in Europe is unavailable. IBD was identified through ICD-10 K50 and K51 code groups. We took an actual costing approach, compared expenditures to G-DRG and non-DRG proceeds and performed detailed cost center and type accounting to identify coverage determinants. Of all 3093 hospitalized cases at our department, 164 were CD and 157 UC inpatients in 2012. On average, they were 44.1 (CD 44.9 UC 43.3 all 58) years old, stayed 10.1 (CD 11.8 UC 8.4 vs. all 8) days, carried 5.8 (CD 6.4 UC 5.2 vs. all 6.8) secondary diagnoses, received 7.4 (CD 7.7 UC 7 vs. all 6.2) procedures, had a higher cost weight (CD 2.8 UC 2.4 vs. all 1.6) and required more intense nursing. Their care was more costly (means: total cost IBD 8477€ CD 9051€ UC 7903€ vs. all 5078€). However, expenditures were not fully recovered by DRG proceeds (means: IBD 7413€, CD 8441€, UC 6384€ vs all 4758€). We discovered substantial disease specific mismatches in cost centers and types and identified the medical ward personnel and materials budgets to be most imbalanced. Non-DRG proceeds were almost double (IBD 16.1% vs. all 8.2%), but did not balance deficits at total coverage analysis, that found medications (antimicrobials, biologics and blood products), medical materials (mostly endoscopy items) to contribute most to the deficit. DRGs challenge sophisticated IBD care.

Prime Contract Awards Over $25,000 by Major System, Contractor and State. Part 1. (AAA-BSG)

DTIC Science & Technology

1989-01-01

estimated to average I hour per response. including the time for reviewng instructions searching existing data sources,gathering and maintaining the data ...JeffersonDavis highway. Suite 1204, Arlington, VA 22202,4302, and to the Office of Management and Budget. Paperwork Reduction Prolect (0704.018I), Washington, DC...IN W) MNMP l )C)C) ciMP l l1-I z cJ~ ICC cl IN C) 0(Du’)-. It) Nr.~- (DM In- - 141 I 4~~ t 06 0. E E I I CLcIcII T . I I UcI . u ) c ct)a 4)C ) wa

The K-8 Aeronautics Internet Textbook

NASA Technical Reports Server (NTRS)

2002-01-01

Efforts were focused on web site migration, from UC (University of California) Davis to the National Business Aviation Association's (NBAA) web site. K8AIT (K-8 Aeronautics Internet Textbook), which has remained an unadvertised web site, receives almost two million hits per month. Project continuation funding with the National Business Aviation Association is being pursued. A Memorandum of Understanding (MOU) between NASA Ames LTP (Learning Technologies Project) and Cislunar has been drafted and approved by NASA's legal department. Additional web content on space flight and the Wright brothers has been added in English and Spanish.

pYEMF, a pUC18-derived XcmI T-vector for efficient cloning of PCR products.

PubMed

Gu, Jingsong; Ye, Chunjiang

2011-03-01

A 1330-bp DNA sequence with two XcmI cassettes was inserted into pUC18 to construct an efficient XcmI T-vector parent plasmid, pYEMF. The large size of the inserted DNA fragment improved T-vector cleavage efficiency, and guaranteed good separation of the molecular components after restriction digestion. The pYEMF-T-vector generated from parent plasmid pYEMF permits blue/white colony screening; cloning efficiency analysis showed that most white colonies (>75%) were putative transformants which carried the cloning product. The sequence analysis and design approach presented here will facilitate applications in the fields of molecular biology and genetic engineering.

Photographic images captured while sampling for bald eagles near the Davis Pond freshwater diversion structure in Barataria Bay, Louisiana (2009-10)

USGS Publications Warehouse

Jenkins, Jill A.; Jeske, Clinton W.; Allain, Larry K.

2011-01-01

The implementation of freshwater diversions in large-scale coastal restoration schemes presents several scientific and management considerations. Large-scale environmental restructuring necessitates aquatic biomonitoring, and during such field studies, photographs that document animals and habitat may be captured. Among the biomonitoring studies performed in conjunction with the Davis Pond freshwater diversion structure south of New Orleans, Louisiana, only postdiversion study images are readily available, and these are presented here.

Ethnic variations in ulcerative colitis: Experience of an international hospital in Thailand.

PubMed

Permpoon, Vibhakorn; Pongpirul, Krit; Anuras, Sinn

2016-08-06

To investigate the clinical characteristics, treatment, medication use, and treatment response in patients with ulcerative colitis (UC) across ethnic groups. This study retrospectively analyzed medical records of all 268465 patients who visited the Bumrungrad International Digestive Disease Center during 2005-2010. The demographics, clinical characteristics, medication use, results of investigations, and medical and surgical management for patients with UC were evaluated. Evaluation included sigmoidoscopy and colonoscopy performed in compliance with the American Society of Gastrointestinal Endoscopy practice guidelines. Patient ethnicities were categorized into seven groups: Thai, Oriental, South Asian (SA), Middle Eastern (ME), Caucasian, African, and Hispanic. UC pathological severity was classified into inactive, mild, moderate, and severe. Associations between categorical variables were analyzed using the χ(2) or Fischer's exact test. Associations between categorical and interval variables were analyzed using Student's t-test and/or analysis of covariance. UC was diagnosed in 371 of the 268465 patients: male 56.33%; ME 42%, Caucasian 23%, and Thai 19%. Annual incidence of UC was 82 cases per 100000 with wide ethnic variation, ranging from 29 to 206 cases per 100000 in Oriental and ME patients, respectively. Of the patients with UC, 16.71% had severe UC with highest incidence among the patients from ME (20.39%) and lowest among the Caucasian population (11.90%). ME had highest proportion of pancolitis (52.90%), followed by Caucasian (45.35%) and Asian (34.40%). Only 20.93% of Caucasian patients received steroid, compared with 26.40% and 27.10% of Asian and Middle Eastern, respectively (P = 0.732). Overall, 13.72% of UC patients did not respond to steroid therapy, with non-significantly higher proportions of non-responders among Asian and Middle Eastern patients (15.22% and 15.04%, respectively) (P = 0.781). On average, 5.93% underwent surgical management with

Golimumab in unresponsive ulcerative colitis

PubMed Central

Lippert, Elisabeth; Müller, Martina; Ott, Claudia

2014-01-01

Ulcerative colitis (UC) is a chronic inflammation mainly affecting the colon mucosa. It predominantly occurs in younger patients. Until recently, the main goals in the treatment of UC were to temper the symptoms, such as diarrhea, pain, and weight loss, by using mesalazine and steroids. With newer medications, such as immunomodulators (thiopurines) and the biologics providing blockade of tumor necrosis factor (TNF), the goals of the therapy in UC have changed to long-term remission and mucosal healing. The first available anti-TNF therapy in UC included infusion therapy with infliximab every few weeks. In 2012, subcutaneously administered adalimumab gained approval for the treatment of UC in Germany. In patients with a mild disease, therapy with mesalazine, orally or topically, can be sufficient. In patients with moderate to severe disease, therapy with azathioprine or anti-TNF is often required to reach disease control; however, this is only efficient in about two-thirds of patients. Some patients either show no response or a lost response while on treatment. So, further medical options are warranted in the treatment of UC. With golimumab, a new approach in the treatment of mild to moderate UC recently became available in Germany and is a promising new option in the therapy regimen for patients with UC. PMID:24904202

Golimumab in unresponsive ulcerative colitis.

PubMed

Lippert, Elisabeth; Müller, Martina; Ott, Claudia

2014-01-01

Ulcerative colitis (UC) is a chronic inflammation mainly affecting the colon mucosa. It predominantly occurs in younger patients. Until recently, the main goals in the treatment of UC were to temper the symptoms, such as diarrhea, pain, and weight loss, by using mesalazine and steroids. With newer medications, such as immunomodulators (thiopurines) and the biologics providing blockade of tumor necrosis factor (TNF), the goals of the therapy in UC have changed to long-term remission and mucosal healing. The first available anti-TNF therapy in UC included infusion therapy with infliximab every few weeks. In 2012, subcutaneously administered adalimumab gained approval for the treatment of UC in Germany. In patients with a mild disease, therapy with mesalazine, orally or topically, can be sufficient. In patients with moderate to severe disease, therapy with azathioprine or anti-TNF is often required to reach disease control; however, this is only efficient in about two-thirds of patients. Some patients either show no response or a lost response while on treatment. So, further medical options are warranted in the treatment of UC. With golimumab, a new approach in the treatment of mild to moderate UC recently became available in Germany and is a promising new option in the therapy regimen for patients with UC.

Evaluating the capacity of California's publicly funded universities to provide medication abortion.

PubMed

Raifman, Sarah; Anderson, Patricia; Kaller, Shelly; Tober, Diane; Grossman, Daniel

2018-05-18

To explore capacity of University of California (UC) and California State University (CSU) student health centers (SHCs) to provide medication abortion (MA) and SHC staff perspectives on providing MA. SHC staff completed an online survey; we conducted site visits and conference calls with a subset of SHCs. The survey focused on barriers to abortion, resources needed for MA, and potential benefits and challenges. 11 UCs (100%) and 20 CSUs (87%) completed surveys. All facilities provided basic primary care, including sexual and reproductive health services and some contraceptive services, but not abortion. All sites had adequate staffing and physical plant, but most would require training, access to ultrasound when needed, 24-hour hotlines (CSUs), and back-up care to provide MA. It would be feasible to provide MA at SHCs, but investment is needed to support staff training, equipment, 24-hour hotlines, back-up care, and minimal security upgrades, in order to implement MA services. If SB320 is passed, provision of MA services at student health centers could improve access to early abortion for students in California. This model may be scaled up at other universities around the country. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

The BADER Consortium

DTIC Science & Technology

2012-10-01

Reed National Military Medical Center; C-Motion Inc . in Germantown, Md.; and the University of Michigan. Funding for this Orthopaedic...IRB of record outside the MTFs (Davis) • Initiated the development of partnership with Nike , USA (Davis) • Development and implementation of an...Christiana Care Health Systems Walter Reed National Military Medical Center University of Texas – Austin C-Motion, Inc Department of Veteran’s

The Expenditures for Academic Inpatient Care of Inflammatory Bowel Disease Patients Are Almost Double Compared with Average Academic Gastroenterology and Hepatology Cases and Not Fully Recovered by Diagnosis-Related Group (DRG) Proceeds

PubMed Central

Baumgart, Daniel C.; le Claire, Marie

2016-01-01

Background Crohn’s disease (CD) and ulcerative colitis (UC) challenge economies worldwide. Detailed health economic data of DRG based academic inpatient care for inflammatory bowel disease (IBD) patients in Europe is unavailable. Methods IBD was identified through ICD-10 K50 and K51 code groups. We took an actual costing approach, compared expenditures to G-DRG and non-DRG proceeds and performed detailed cost center and type accounting to identify coverage determinants. Results Of all 3093 hospitalized cases at our department, 164 were CD and 157 UC inpatients in 2012. On average, they were 44.1 (CD 44.9 UC 43.3 all 58) years old, stayed 10.1 (CD 11.8 UC 8.4 vs. all 8) days, carried 5.8 (CD 6.4 UC 5.2 vs. all 6.8) secondary diagnoses, received 7.4 (CD 7.7 UC 7 vs. all 6.2) procedures, had a higher cost weight (CD 2.8 UC 2.4 vs. all 1.6) and required more intense nursing. Their care was more costly (means: total cost IBD 8477€ CD 9051€ UC 7903€ vs. all 5078€). However, expenditures were not fully recovered by DRG proceeds (means: IBD 7413€, CD 8441€, UC 6384€ vs all 4758€). We discovered substantial disease specific mismatches in cost centers and types and identified the medical ward personnel and materials budgets to be most imbalanced. Non-DRG proceeds were almost double (IBD 16.1% vs. all 8.2%), but did not balance deficits at total coverage analysis, that found medications (antimicrobials, biologics and blood products), medical materials (mostly endoscopy items) to contribute most to the deficit. Conclusions DRGs challenge sophisticated IBD care. PMID:26784027

Temporal and taxonomic contrasts in coral growth at Davies Reef, central Great Barrier Reef, Australia

NASA Astrophysics Data System (ADS)

Anderson, Kristen D.; Cantin, Neal E.; Heron, Scott F.; Lough, Janice M.; Pratchett, Morgan S.

2018-06-01

Demographic processes, such as growth, can have an important influence on the population and community structure of reef-building corals. Importantly, ongoing changes in environmental conditions (e.g. ocean warming) are expected to affect coral growth, contributing to changes in the structure of coral populations and communities. This study quantified contemporary growth rates (linear extension and calcification) for the staghorn coral, Acropora muricata, at Davies Reef, central Great Barrier Reef, Australia. Growth rates were measured at three different depths (5, 10, and 15 m) over 2 yr (2012-2014) assessing both seasonal and inter-annual variability. Results of this study were compared to equivalent measurements made in 1980-1982 at the same location. To assist in understanding inter-annual variability in coral growth, we also examined annual growth bands from massive Porites providing continuous growth and records of flooding history for Davies Reef over the period 1979-2012. Linear extension rates of A. muricata were substantially (11-62%) lower in 2012-2014 compared to 1980-1982, especially at 10 and 15 m depths. These declines in growth coincide with a + 0.14 °C change in annual mean temperature. For massive Porites, however, calcification rates were highly variable among years and there was no discernible long-term change in growth despite sustained increases in temperature of 0.064 °C per decade. Apparent differences in the growth rates of Acropora between 1980-1982 and 2012-2014 may reflect inter-annual variation in coral growth (as seen for massive Porites), though it is known branching Acropora is much more sensitive to changing environmental conditions than massive corals. There are persistent issues in assessing the sensitivities of branching corals to environmental change due to limited capacity for retrospective analyses of growth, but given their disproportionate contribution to habitat complexity and reef structure, it is critical to ascertain

WiFi RFID demonstration for resource tracking in a statewide disaster drill.

PubMed

Cole, Stacey L; Siddiqui, Javeed; Harry, David J; Sandrock, Christian E

2011-01-01

To investigate the capabilities of Radio Frequency Identification (RFID) tracking of patients and medical equipment during a simulated disaster response scenario. RFID infrastructure was deployed at two small rural hospitals, in one large academic medical center and in two vehicles. Several item types from the mutual aid equipment list were selected for tracking during the demonstration. A central database server was installed at the UC Davis Medical Center (UCDMC) that collected RFID information from all constituent sites. The system was tested during a statewide disaster drill. During the drill, volunteers at UCDMC were selected to locate assets using the traditional method of locating resources and then using the RFID system. This study demonstrated the effectiveness of RFID infrastructure in real-time resource identification and tracking. Volunteers at UCDMC were able to locate assets substantially faster using RFID, demonstrating that real-time geolocation can be substantially more efficient and accurate than traditional manual methods. A mobile, Global Positioning System (GPS)-enabled RFID system was installed in a pediatric ambulance and connected to the central RFID database via secure cellular communication. This system is unique in that it provides for seamless region-wide tracking that adaptively uses and seamlessly integrates both outdoor cellular-based mobile tracking and indoor WiFi-based tracking. RFID tracking can provide a real-time picture of the medical situation across medical facilities and other critical locations, leading to a more coordinated deployment of resources. The RFID system deployed during this study demonstrated the potential to improve the ability to locate and track victims, healthcare professionals, and medical equipment during a region-wide disaster.

Response to the Letter to the Editor of Crop Science from Donald R. Davis regarding our research article published in Crop Science (2011: 51:2721-2727)

USDA-ARS?s Scientific Manuscript database

This letter serves as a response to the Letter to the Editor submitted by Donald R. Davis regarding our research article entitled “Mineral Concentration of Broccoli Florets in Relation to Year of Cultivar Release” published in Crop Science (2011, 51:2721-2727). In our manuscript, we clearly stated ...

Colectomy is a risk factor for venous thromboembolism in ulcerative colitis.

PubMed

Kaplan, Gilaad G; Lim, Allen; Seow, Cynthia H; Moran, Gordon W; Ghosh, Subrata; Leung, Yvette; Debruyn, Jennifer; Nguyen, Geoffrey C; Hubbard, James; Panaccione, Remo

2015-01-28

To compare venous thromboembolism (VTE) in hospitalized ulcerative colitis (UC) patients who respond to medical management to patients requiring colectomy. Population-based surveillance from 1997 to 2009 was used to identify all adults admitted to hospital for a flare of UC and those patients who underwent colectomy. All medical charts were reviewed to confirm the diagnosis and extract clinically relevant information. UC patients were stratified by: (1) responsive to inpatient medical therapy (n=382); (2) medically refractory requiring emergent colectomy (n=309); and (3) elective colectomy (n=329). The primary outcome was the development of VTE during hospitalization or within 6 mo of discharge. Heparin prophylaxis to prevent VTE was assessed. Logistic regression analysis determined the effect of disease course (i.e., responsive to medical therapy, medically refractory, and elective colectomy) on VTE after adjusting for confounders including age, sex, smoking, disease activity, comorbidities, extent of disease, and IBD medications (i.e., corticosteroids, mesalamine, azathioprine, and infliximab). Point estimates were presented as odds ratios (OR) with 95%CI. The prevalence of VTE among patients with UC who responded to medical therapy was 1.3% and only 16% of these patients received heparin prophylaxis. In contrast, VTE was higher among patients who underwent an emergent (8.7%) and elective (4.9%) colectomy, despite greater than 90% of patients receiving postoperative heparin prophylaxis. The most common site of VTE was intra-abdominal (45.8%) followed by lower extremity (19.6%). VTE was diagnosed after discharge from hospital in 16.7% of cases. Elective (adjusted OR=3.69; 95%CI: 1.30-10.44) and emergent colectomy (adjusted OR=5.28; 95%CI: 1.93-14.45) were significant risk factors for VTE as compared to medically responsive UC patients. Furthermore, the odds of a VTE significantly increased across time (adjusted OR=1.10; 95%CI: 1.01-1.20). Age, sex, comorbidities

Whole-Blood Thiopurine S-Methyltransferase Genotype and Phenotype Concordance in Iranian Kurdish Ulcerative Colitis (UC) Patients.

PubMed

Bahrehmand, Fariborz; Vaisi-Raygani, Asad; Kiani, Amir; Bashiri, Homayoun; Zobeiri, Mahdi; Tanhapour, Maryam; Pourmotabbed, Tayebeh

2017-05-01

Thiopurine methyl transferase (TPMT), a drug-metabolizing enzyme, catalyzes methylation and consequently, the metabolism of thiopurine compounds used for treatment of inflammatory bowel disease (IBD). Individuals who are homozygous recessive or have extremely low TPMT activity need to avoid thiopurines because of concern for significant leukopenia. The aim of this research was to determine TPMT phenotypes and genotypes in IBD patients to predict the risk of thiopurine toxicity before treatment. The present case-control study consisted of 210 ulcerative colitis patients and 212 unrelated healthy controls from the population of western Iran. TPMT phenotype and genotype were determined by HPLC and allele specific PCR and PCR-RFLP, respectively. TPMT phenotyping and genotyping were compatible and demonstrated no frequency for deficient, 2.2% for low, and 97.8% for normal-activity which is different compared with the results of other studies. There was a significant negative correlation between TPMT activities as calculated based on nmol6MTG/gHb/h and the Hb levels in both UC (r = -0.54, p < 0.001) and control groups (r = -0.27, p < 0.001). Interestingly, a significant positive correlation between Hb levels and TPMT activities was seen when the enzyme activity was calculated in mU/L in both UC patients (r = 0.14, p = 0.05) and in control subjects (r = 0.43, p < 0.001). The overall concordance rate between TPMT phenotypes and genotypes of mutants to alleles (9 out of 422), based on receiver-operating characteristic (ROC) curve, yielded a sensitivity of 94.7% and specificity of 90% for mU/L and a sensitivity of 85.6% and specificity of 90% for nmol6MTG/gHb/h. The use of mU/L is more appropriate than nmol6MTG/gHb/h for expressing TPMT activity, and there is better correlation between genotypes and phenotypes of TPMT based on mU/L. The frequency of known mutant TPMT alleles in western Iran (Kurd population) is low suggesting low risk of thiopurine drug toxicity in IBD

Gastroenterologists' Perceptions Regarding Ulcerative Colitis and Its Management: Results from a Large-Scale Survey.

PubMed

Lasch, Karen; Liu, Stephen; Ursos, Lyann; Mody, Reema; King-Concialdi, Kristen; DiBonaventura, Marco; Leberman, Julie; Dubinsky, Marla

2016-10-01

Misperceptions about ulcerative colitis (UC) may influence management strategies and limit opportunities for improving patient outcomes. This study assessed physicians' perceptions of UC, concepts of disease severity and remission, and treatment goals. Gastroenterologists who typically treated ≥10 adults with UC per month were recruited for a large-scale, web-based survey. Participants were asked about their perceptions of UC (often vs. Crohn's disease [CD]), treatment goals, and medication use. Response data were evaluated via descriptive statistics and univariate and multivariable analyses. Gastroenterologists (N = 500) with a mean of 16.5 years (standard deviation, 8.7 years) in practice participated. In comparison to CD, survey respondents perceived UC as being easier to diagnose, having better treatment outcomes, and being associated with later prescribing of biologics. Treatment goals commonly considered to have the greatest importance included quality of life improvement (31.2% of respondents), maintenance of clinical remission (17.4%), and mucosal healing (17.4%). When respondents evaluated the performance of medication classes in achieving these goals, biologics were rated significantly higher than all other classes (P < 0.05). However, the most common drivers for the initiation of biologic therapy were the development of steroid refractoriness (66.8%) and steroid dependency (65.8%). Medication class use by UC severity was generally consistent with the traditional step-up approach to UC therapy, with biologics being used most commonly for severe UC. These results suggest a possible disparity between treatment goals and therapeutic management in UC. An increased awareness of general UC perceptions is an important step toward a better overall understanding of the disease and, ultimately, toward improved management aligned with treatment goals. This study was sponsored by the American Gastroenterological Association (AGA), and the design and conduct

Innocence, Protection and Failure: Bringing the Child Subject to the Centre of the Politics of the Family. A Response to Cristyn Davies and Kerry Robinson

ERIC Educational Resources Information Center

Hopkins, Lucy

2013-01-01

In response to Davies and Robinson's article looking at how queer families are positioned and position themselves in relation to neoliberalism, this article brings the child to the centre of the debate to examine how reading the child subject in terms of discourses of innocence and protection might work to maintain the hegemony of the…

West Village Student Housing Phase I: Apartment Monitoring and Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

German, A.; Bell, C.; Dakin, B.

Building America team Alliance for Residential Building Innovation (ARBI) worked with the University of California, Davis (UC Davis) and the developer partner West Village Community Partnership (WVCP) to evaluate performance on 192 student apartments completed in September, 2011 as part of Phase I of the multi-purpose West Village project. West Village, the largest planned zero net energy community in the United States. The campus neighborhood is designed to enable faculty, staff and students to affordably live near campus, take advantage of environmentally friendly transportation options, and participate fully in campus life. The aggressive energy efficiency measures that are incorporated inmore » the design contribute to source energy reductions of 37% over the B10 Benchmark. The energy efficiency measures that are incorporated into these apartments include increased wall & attic insulation, high performance windows, high efficiency heat pumps for heating and cooling, central heat pump water heaters (HPWHs), 100% high efficacy lighting, and ENERGY STAR major appliances. Results discuss how measured energy use compares to modeling estimates over a 10 month monitoring period and includes a cost effective evaluation.« less

Impact of a Patient Support Program on Patient Adherence to Adalimumab and Direct Medical Costs in Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Psoriasis, Psoriatic Arthritis, and Ankylosing Spondylitis.

PubMed

Rubin, David T; Mittal, Manish; Davis, Matthew; Johnson, Scott; Chao, Jingdong; Skup, Martha

2017-08-01

12 months following the index date using t-tests. A total of 2,386 patients were included in the study and were allocated to the PSP (n = 1,199) and non-PSP (n = 1,187) cohorts. Baseline characteristics were similar between cohorts. During the follow-up period, adalimumab adherence was 14% greater in the PSP cohort than for the non-PSP cohort (67.0% vs. 58.8%; P < 0.001). The discontinuation rate for adalimumab was 14% lower in the PSP cohort compared with the non-PSP cohort (39.7% vs. 46.2%; P = 0.001). Univariate analyses showed that PSP patients had 23% lower 12-month medical costs (excluding costs for biologic treatment) than did non-PSP patients ($18,322 vs. $23,679; P = 0.003). Disease-related medical costs were 22% lower for PSP than for non-PSP patients ($8,001 vs. $10,202; P = 0.045). Total costs were 10% lower for PSP than for non-PSP patients ($35,741 vs. $39,713; P = 0.030). Patient enrollment in the PSP was associated with greater adherence, improved persistence, and reduced medical (all-cause and disease-related) and total health care costs for patients receiving adalimumab therapy. Design, study conduct, and financial support for this study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the abstract. All authors contributed to the development of the publication and maintained control over the final content. Rubin has received consulting fees or research support from AbbVie, Amgen, Emmi, Genentech, Ironwood, Janssen, Pfizer, Prometheus, Shire, and Takeda. Skup and Mittal are employees and stockholders of AbbVie. Chao was an employee of AbbVie at the time of the study and may hold AbbVie stock. Johnson and Davis are employees of Medicus Economics, which received payment from AbbVie to participate in this research. Study concept and design were contributed by Rubin, Mittal, Chao, and Skup, along with Davis and Johnson. Davis and Johnson took the lead in data collection, with assistance from the other

A content-based image retrieval method for optical colonoscopy images based on image recognition techniques

NASA Astrophysics Data System (ADS)

Nosato, Hirokazu; Sakanashi, Hidenori; Takahashi, Eiichi; Murakawa, Masahiro

2015-03-01

This paper proposes a content-based image retrieval method for optical colonoscopy images that can find images similar to ones being diagnosed. Optical colonoscopy is a method of direct observation for colons and rectums to diagnose bowel diseases. It is the most common procedure for screening, surveillance and treatment. However, diagnostic accuracy for intractable inflammatory bowel diseases, such as ulcerative colitis (UC), is highly dependent on the experience and knowledge of the medical doctor, because there is considerable variety in the appearances of colonic mucosa within inflammations with UC. In order to solve this issue, this paper proposes a content-based image retrieval method based on image recognition techniques. The proposed retrieval method can find similar images from a database of images diagnosed as UC, and can potentially furnish the medical records associated with the retrieved images to assist the UC diagnosis. Within the proposed method, color histogram features and higher order local auto-correlation (HLAC) features are adopted to represent the color information and geometrical information of optical colonoscopy images, respectively. Moreover, considering various characteristics of UC colonoscopy images, such as vascular patterns and the roughness of the colonic mucosa, we also propose an image enhancement method to highlight the appearances of colonic mucosa in UC. In an experiment using 161 UC images from 32 patients, we demonstrate that our method improves the accuracy of retrieving similar UC images.

Reduced total serum bilirubin levels are associated with ulcerative colitis.

PubMed

Schieffer, Kathleen M; Bruffy, Shannon M; Rauscher, Richard; Koltun, Walter A; Yochum, Gregory S; Gallagher, Carla J

2017-01-01

Chronic inflammation associated with inflammatory bowel disease (IBD) results in increased oxidative stress that damages the colonic microenvironment. Low levels of serum bilirubin, an endogenous antioxidant, have been associated with increased risk for Crohn's disease (CD). Therefore, the aim of this study was to examine whether total serum bilirubin levels are associated with ulcerative colitis (UC). We identified a retrospective case-control population (n = 6,649) from a single tertiary care center, Penn State Hershey Medical Center (PSU) and a validation cohort (n = 1,996) from Virginia Commonwealth University Medical Center (VCU). Cases were age- and sex-matched to controls (PSU: CD n = 254, UC n = 187; VCU: CD n = 233, UC n = 124). Total serum bilirubin levels were obtained from de-identified medical records and segregated into quartiles. Logistic regression analysis was performed on each quartile of total serum bilirubin compared to the last quartile (highest bilirubin levels) to determine the association of total serum bilirubin with UC. Similar to CD patients, UC patients demonstrated reduced levels of total serum bilirubin compared to controls at PSU and VCU. The lowest quartile of total serum bilirubin was independently associated with UC for the PSU (OR: 1.98 [95% CI: 1.09-3.63]) and VCU cohorts (OR: 6.07 [95% CI: 3.01-12.75]). Lower levels of the antioxidant bilirubin may reduce the capability of UC patients to remove reactive oxygen species leading to an increase in intestinal injury. Therapeutics that reduce oxidative stress may be beneficial for these patients.

Reduced total serum bilirubin levels are associated with ulcerative colitis

PubMed Central

Schieffer, Kathleen M.; Bruffy, Shannon M.; Rauscher, Richard; Koltun, Walter A.; Gallagher, Carla J.

2017-01-01

Chronic inflammation associated with inflammatory bowel disease (IBD) results in increased oxidative stress that damages the colonic microenvironment. Low levels of serum bilirubin, an endogenous antioxidant, have been associated with increased risk for Crohn’s disease (CD). Therefore, the aim of this study was to examine whether total serum bilirubin levels are associated with ulcerative colitis (UC). We identified a retrospective case-control population (n = 6,649) from a single tertiary care center, Penn State Hershey Medical Center (PSU) and a validation cohort (n = 1,996) from Virginia Commonwealth University Medical Center (VCU). Cases were age- and sex-matched to controls (PSU: CD n = 254, UC n = 187; VCU: CD n = 233, UC n = 124). Total serum bilirubin levels were obtained from de-identified medical records and segregated into quartiles. Logistic regression analysis was performed on each quartile of total serum bilirubin compared to the last quartile (highest bilirubin levels) to determine the association of total serum bilirubin with UC. Similar to CD patients, UC patients demonstrated reduced levels of total serum bilirubin compared to controls at PSU and VCU. The lowest quartile of total serum bilirubin was independently associated with UC for the PSU (OR: 1.98 [95% CI: 1.09–3.63]) and VCU cohorts (OR: 6.07 [95% CI: 3.01–12.75]). Lower levels of the antioxidant bilirubin may reduce the capability of UC patients to remove reactive oxygen species leading to an increase in intestinal injury. Therapeutics that reduce oxidative stress may be beneficial for these patients. PMID:28594959

Educating tomorrow's doctors: A cross sectional survey of emotional intelligence and empathy in medical students of Lahore.

PubMed

Imran, Nazish; Awais Aftab, Muhammad; Haider, Imran Ijaz; Farhat, Anam

2013-05-01

Medical education in Pakistan traditionally emphasizes physician's biomedical knowledge with less emphasis on interpersonal skills and ability to relate to the patients. This study explored the emotional intelligence & empathy of undergraduate medical students and investigated its relationship with various factors to act as baseline for future work in this area. The Schutte Emotional Intelligence scale and Davis' Interpersonal Reactivity Index in addition to socio demographic questionnaire were administered to first year and final year medical undergraduates of two medical Institutions in Lahore, Pakistan. Data was analyzed by using SPSS 17 version. The overall mean scores for medical students both on emotional intelligence and empathy is significantly lower than that found in previous literature, highlighting that medical students do not appear to fare better than average people in EQ. Women showed statistically significant higher scores on Appraisal of emotions , Regulation of emotions, Empathic concern Scale & Personal distress scale. Comparison of EI & IRI of students according to medical college year did not show any statistical significance. Current medical curriculum and training in Pakistan does not appear to increase EI abilities which are building blocks that may allow students and residents to develop competence. Medical educators in Pakistan should look for ways to incorporate emotional intelligence in medical curriculum which will ultimately contribute towards patient centered practice, patient satisfaction as well as effective communication skills.

A variation of the Davis-Smith method for in-flight determination of spacecraft magnetic fields.

NASA Technical Reports Server (NTRS)

Belcher, J. W.

1973-01-01

A variation of a procedure developed by Davis and Smith (1968) is presented for the in-flight determination of spacecraft magnetic fields. Both methods take statistical advantage of the observation that fluctuations in the interplanetary magnetic field over short periods of time are primarily changes in direction rather than in magnitude. During typical solar wind conditions between 0.8 and 1.0 AU, a statistical analysis of 2-3 days of continuous interplanetary field measurements yields an estimate of a constant spacecraft field with an uncertainty of plus or minus 0.25 gamma in the direction radial to the sun and plus or minus 15 gammas in the directions transverse to the radial. The method is also of use in estimating variable spacecraft fields with gradients of the order of 0.1 gamma/day and less and in other special circumstances.

Integration of an expert teaching assistant with distance learning software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fonseca, S.P.; Reed, N.E.

1996-12-31

The Remote Teaching Assistant (RTA) software currently under development at UC Davis allows students and Teaching Assistants (TA`s) to interact through multimedia communication via the Internet. To resolve the problem of TA unavailability and limited knowledge, an Expert Teaching Assistant (ETA) module is being developed. When TA`s are not on-line, students in need of help consult ETA. The focus of this research is the development and integration of ETA with RTA, the establishment of an architecture suitable for use with education (the domain) in any sub-domain (course), and the creation of a mechanism usable by non-technical personnel to maintain knowledgemore » bases.« less

Enter Sandbox

NASA Astrophysics Data System (ADS)

Clucas, T.; Wirth, G. S.

2015-12-01

Interactive geospatial education tools can excite students and public audiences alike. Alaska EPSCoR and UAF GINA have taken one such tool - an augmented-reality sandbox invented at UC-Davis - and created a completely mobile version, which can be easily transported and deployed on and off the road system. In addition, EPSCoR has developed model curricula that use the sandbox to teach basic topography and hydrology skills. More advanced curricular modules in development will teach about flooding, tsunamis, and other hydrologic and landscape hazards. Instructions on building a mobile sandbox, curricula, and video of the sandbox in action are available at www.alaska.edu/epscor/Augmented-Reality%20Sandbox/

Public health education at the University of California, Davis: past, present, and future programs.

PubMed

Hird, David W; Lloyd, K C Kent; McCurdy, Stephen A; Schenker, Marc B; Troidl, John J; Kass, Philip H

2008-01-01

This article reviews the history of public-health education at the University of California, Davis, from the inception of the Master of Preventive Veterinary Medicine Program in the School of Veterinary Medicine through the creation of the Master of Public Health Program offered jointly by the Schools of Medicine and Veterinary Medicine. The long history of collaborative teaching and research between the schools, as well as the university's close proximity to and relationship with numerous university-affiliated and state public-health agencies, has created remarkable opportunities for novel and creative public-health education. The university is already anticipating the approval of a School of Public Health on its campus, which will create even more educational opportunities in both human and veterinary public-health disciplines. Given the projected shortfall of veterinarians entering such fields, the opportunity of a novel Doctor of Public Health degree program specifically suited to the needs of veterinary medicine is also discussed as a means of addressing this shortage.

Current approaches to the management of new-onset ulcerative colitis

PubMed Central

Marchioni Beery, Renée; Kane, Sunanda

2014-01-01

Ulcerative colitis (UC) is an idiopathic, inflammatory gastrointestinal disease of the colon. As a chronic condition, UC follows a relapsing and remitting course with medical maintenance during periods of quiescent disease and appropriate escalation of therapy during times of flare. Initial treatment strategies must not only take into account current clinical presentation (with specific regard for extent and severity of disease activity) but must also take into consideration treatment options for the long-term. The following review offers an approach to new-onset UC with a focus on early treatment strategies. An introduction to the disease entity is provided along with an approach to initial diagnosis. Stratification of patients based on clinical parameters, disease extent, and severity of illness is paramount to determining course of therapy. Frequent assessments are required to determine clinical response, and treatment intensification may be warranted if expected improvement goals are not appropriately reached. Mild-to- moderate UC can be managed with aminosalicylates, mesalamine, and topical corticosteroids with oral corticosteroids reserved for unresponsive cases. Moderate-to-severe UC generally requires oral or intravenous corticosteroids in the short-term with consideration of long-term management options such as biologic agents (as initial therapy or in transition from steroids) or thiopurines (as bridging therapy). Patients with severe or fulminant UC who are recalcitrant to medical therapy or who develop disease complications (such as toxic megacolon) should be considered for colectomy. Early surgical referral in severe or refractory UC is crucial, and colectomy may be a life-saving procedure. The authors provide a comprehensive evidence-based approach to current treatment options for new-onset UC with discussion of long-term therapeutic efficacy and safety, patient-centered perspectives including quality of life and medication compliance, and future

Rotenone formulation fate in Lake Davis following the 2007 treatment.

PubMed

Vasquez, Martice E; Rinderneck, Janna; Newman, Julie; McMillin, Stella; Finlayson, Brian; Mekebri, Abdou; Crane, David; Tjeerdema, Ronald S

2012-05-01

In September 2007, Lake Davis (near Portola, California) was treated by the California Department of Fish and Game with CFT Legumine, a rotenone formulation, to eradicate the invasive northern pike (Esox lucius). The objective of this report is to describe the fate of the five major formulation constituents-rotenone, rotenolone, methyl pyrrolidone (MP), diethylene glycol monethyl ether (DEGEE), and Fennedefo 99-in water, sediment, and brown bullhead catfish (Ameiurus nebulosus; a rotenone-resistant species) by determination of their half-lives (t(1/2)) and pseudo first-order dissipation rate constants (k). The respective t(1/2) values in water for rotenone, rotenolone, MP, DEGEE, and Fennedefo 99 were 5.6, 11.1, 4.6, 7.7, and 13.5 d; in sediments they were 31.1, 31.8, 10.0, not able to calculate, and 48.5 d; and in tissues were 6.1, 12.7, 3.7, 3.2, and 10.4 d, respectively. Components possessing low water solubility values (rotenone and rotenolone) persisted longer in sediments (not detectable after 157 d) and tissues (<212 d) compared with water, whereas the water-miscible components (MP and DEGEE) dissipated more quickly from all matrices, except for Fennedefo 99, which was the most persistent in water (83 d). None of the constituents was found to bioaccumulate in tissues as a result of treatment. In essence, the physicochemical properties of the chemical constituents effectively dictated their fate in the lake following treatment. Copyright © 2012 SETAC.

Bringing a Perspective from Outside the Field: A Commentary on Davis et al.'s (2010) Use of a Modified Regression Discontinuity Design to Evaluate a Gifted Program

ERIC Educational Resources Information Center

Adelson, Jill L.; Kelcey, Benjamin

2016-01-01

In this commentary of "Evaluating the Gifted Program of an Urban School District Using a Modified Regression Discontinuity Design" by Davis, Engberg, Epple, Sieg, and Zimmer, we examine the background of the study, critique the methods used, and discuss the results and implications. The study used a fuzzy regression discontinuity design…

Educating tomorrow’s doctors: A cross sectional survey of emotional intelligence and empathy in medical students of Lahore

PubMed Central

Imran, Nazish; Awais Aftab, Muhammad; Haider, Imran Ijaz; Farhat, Anam

2013-01-01

Objective: Medical education in Pakistan traditionally emphasizes physician’s biomedical knowledge with less emphasis on interpersonal skills and ability to relate to the patients. This study explored the emotional intelligence & empathy of undergraduate medical students and investigated its relationship with various factors to act as baseline for future work in this area. Methodology: The Schutte Emotional Intelligence scale and Davis' Interpersonal Reactivity Index in addition to socio demographic questionnaire were administered to first year and final year medical undergraduates of two medical Institutions in Lahore, Pakistan. Data was analyzed by using SPSS 17 version. Results: The overall mean scores for medical students both on emotional intelligence and empathy is significantly lower than that found in previous literature, highlighting that medical students do not appear to fare better than average people in EQ. Women showed statistically significant higher scores on Appraisal of emotions , Regulation of emotions, Empathic concern Scale & Personal distress scale. Comparison of EI & IRI of students according to medical college year did not show any statistical significance. Conclusion: Current medical curriculum and training in Pakistan does not appear to increase EI abilities which are building blocks that may allow students and residents to develop competence. Medical educators in Pakistan should look for ways to incorporate emotional intelligence in medical curriculum which will ultimately contribute towards patient centered practice, patient satisfaction as well as effective communication skills. PMID:24353613

Genotypic and phenotypic evaluation of off-type grasses in hybrid bermudagrass (Cynodon dactylon (L.) Pers. x C. transvaalensis burtt-Davy) putting greens using genotyping-by-sequencing and morphological characterization

USDA-ARS?s Scientific Manuscript database

Interspecific hybrid bermudagrass (Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy) is one of the most widely used grasses on golf courses, with cultivars derived from ‘Tifgreen’ or ‘Tifdwarf’ particularly used for putting greens in the southern agronomic region. Many bermudagrass cultiv...

The Integrated Sequence: An Innovative Component of Four Courses in the General Education Program at Davis & Elkins College. A Digest of Program Elements, Developmental Background, and Faculty Dynamics.

ERIC Educational Resources Information Center

Gartmann, Will

The Integrated Sequence Program at Davis & Elkins College, which consists of four team-taught, interdisciplinary courses, is described, along with the origins and philosophy of the program. The courses are as follows: Human Freedom and the Counterforces (freshman year); World Culture (sophomore year); Comparative Ideas (junior year); and The…

Expansion of the consultation-liaison psychiatry paradigm at a university medical center: integration of diversified clinical and funding models.

PubMed

Bourgeois, James A; Hilty, Donald M; Klein, Sally C; Koike, Alan K; Servis, Mark E; Hales, Robert E

2003-01-01

The perspective of the contemporary Consultation-Liason Service (CLS) psychiatrist is increasingly one of consultant to medical and surgical colleagues in models other than inpatient medical and surgical units. Simultaneously, the need for a clinically and educationally robust inpatient CLS persists despite funding pressures. The University of California, Davis Medical Center Department of Psychiatry has made use of creative organizational and financial models to accomplish the inpatient CLS clinical and educational missions in a fiscally responsible manner. In addition, the department has in recent years expanded the delivery of psychiatry consultation-liaison clinical and educational services to other models of care delivery, broadening the role and influence of the CLS. Several of the initiatives described in this paper parallel an overall evolution of the practice of consultation-liaison psychiatry in response to managed care influences and other systems pressures. This consultation-liaison paradigm expansion with diversified sources of funding support facilitates the development of consultation-liaison psychiatry along additional clinical, administrative, research, and educational dimensions. Other university medical centers may consider adaptation of some of the initiatives described here to their institutions.

Coupling XRD, EXAFS, and 13C NMR to study the effect of the carbon stoichiometry on the local structure of UC(1±x).

PubMed

Carvajal Nuñez, U; Martel, L; Prieur, D; Lopez Honorato, E; Eloirdi, R; Farnan, I; Vitova, T; Somers, J

2013-10-07

A series of uranium carbide samples, prepared by arc melting with a C/U ratio ranging from 0.96 to 1.04, has been studied by X-ray diffraction (XRD), (13)C nuclear magnetic resonance (NMR), and extended X-ray absorption fine structure (EXAFS). XRD determines phase uniqueness and the increase of the lattice parameter versus the carbon content. In contrast, (13)C NMR detects the different carbon environments in the lattice and in this study, clearly identifies the presence of discrete peaks for carbon in the octahedral lattice site in UC and an additional peak associated with excess carbon in hyperstoichiometric samples. Two peaks associated with different levels of carbon deficiency are detected for all hypostoichiometric compositions. More than one carbon environment is always detected by (13)C NMR. This exemplifies the difficulty in obtaining a perfect stoichiometric uranium monocarbide UC(1.00). The (13)C MAS spectra of uranium carbides exhibit the effects resulting from the carbon content on both the broadening of the peaks and on the Knight shift. An abrupt spectral change occurs between hypo- and hyperstoichiometric samples. The results obtained by EXAFS highlight subtle differences between the different stoichiometries, and in the hyperstoichiometric samples, the EXAFS results are consistent with the excess carbon atoms being in the tetrahedral interstitial position.

Titanium Alloys for Critical Ordnance Components. Producers Coordination Meeting on Titanium Materials for Davy Crockett and Other Weapon Systems Held at Watertown Arsenal, Watertown 72, Mass., 14 Apr 60 and Fabricators Coordination Meeting on Titanium Materials for Davy Crockett and Other Weapon Systems Held at Watervliet Arsenal, Watervliet, NY, 15 Apr 1960

DTIC Science & Technology

1960-01-01

Title Agenda and AV^stracts - Watertown Arsenal, Watnrtovm, Mass. llj April i960 - Producers Coordination Meeting, "Titanium Materials for Davy...u.nd J.i’.l~.Jhr!l’ Scicnti~’ic Comp::1.~1y1 Chlc::-.~~o, IJ~~nois. oth :r c~tUl’ll~nt and 1Jl’Occ1t.G.~cn !.Jn.y be uoed if :J..CCC:t.> td )le to

Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.

PubMed Central

Vakulenko, S B; Tóth, M; Taibi, P; Mobashery, S; Lerner, S A

1995-01-01

To examine the effect of disruption of the salt bridge (between Arg-164 and Asp-179 [numbering of Ambler et al. (Biochem J. 267:269-272, 1991)]) that anchors the conserved omega-loop in class A beta-lactamases, we obtained mutant enzymes with each of the 19 other amino acid residues replacing Asp-179 in the TEM beta-lactamase encoded by pUC19 and studied the level of resistance to various beta-lactams conferred by each enzyme. All mutations of Asp-179 compromised the level of resistance to ampicillin, but most of them enhanced resistance to ceftazidime. In contrast, mutations of Asp-179 generally impaired the low levels of resistance to cefepime and aztreonam. One might expect to find clinical isolates with mutant TEM beta-lactamases with replacements of Asp-179 that express an expanded spectrum of resistance to beta-lactams including ceftazidime. PMID:7486939

Study of the Optimum Zone of the Independent Variables of an ORGEL Reactor Connected to a 250-MWeb Power Plant. Self Supporting Fuel Elements Made of UC, with Sap Cladding with Four Fuel Rods and Individual Pressure Tubes; STUDIE DER OPTIMALEN ZONE DER UNABHANGIGEN PARAMETER EINES ORGEL- REAKTORS IN EINEM 250-MWe-KRAFTWERK. SELBST-TRAGENDES BRENNELEMENT AUS UC, SAP-UMHUL-LUNG MIT 4 BRENNSTOFFSTABEN UND INDIVIDUELLEN DRUCKROHREN

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFontaine, F.; Tauch, P.

The optimum range of the independent variables of and ORGEL reactor connected to a 250-Mw power plant (4 fuel rods of UC with individual pressure tubes), as well as the geometry of the reactor core and the operation of the plant, is described. (auth)

Predictors of Outcome in Ulcerative Colitis.

PubMed

Waterman, Matti; Knight, Jo; Dinani, Amreen; Xu, Wei; Stempak, Joanne M; Croitoru, Kenneth; Nguyen, Geoffrey C; Cohen, Zane; McLeod, Robin S; Greenberg, Gordon R; Steinhart, A Hillary; Silverberg, Mark S

2015-09-01

Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors of poor disease course. The aim of this study was to identify clinical and genetic markers that can predict prognosis. Medical records of patients with UC with ≥5 years of follow-up and available DNA and serum were retrospectively assessed. Immunochip was used to genotype loci associated with immune mediated inflammatory disorders (IMIDs), inflammatory bowel diseases, and other single nucleotide polypmorphisms previously associated with disease severity. Serum levels of pANCA, ASCA, CBir1, and OmpC were also evaluated. Requirement for colectomy, medication, and hospitalization were used to group patients into 3 prognostic groups. Six hundred one patients with UC were classified as mild (n = 78), moderate (n = 273), or severe disease (n = 250). Proximal disease location frequencies at diagnosis were 13%, 21%, and 30% for mild, moderate, and severe UC, respectively (P = 0.001). Disease severity was associated with greater proximal extension rates on follow-up (P < 0.0001) and with shorter time to extension (P = 0.03) and to prednisone initiation (P = 0.0004). When comparing severe UC with mild and moderate UC together, diagnosis age >40 and proximal disease location were associated with severe UC (odds ratios = 1.94 and 2.12, respectively). None of the single nucleotide polypmorphisms or serum markers tested was associated with severe UC, proximal disease extension or colectomy. Older age and proximal disease location at diagnosis, but not genetic and serum markers, were associated with a more severe course. Further work is required to identify biomarkers that will predict outcomes in UC.

Health hazard evaluation report No. HHE-80-233-793, Davis Bessie Nuclear Power Station, Toledo Edison Company, United Engineers and Contractors Company (UE and C), Oak Harbor, Ohio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cone, J.; Hartle, R.

1981-01-01

Personal air samples were analyzed and employees were given medical evaluations at Davis Bessie Nuclear Power Station (SIC-4911) in Oak Harbor, Ohio. Requests for evaluation were made by a union representative of the United Engineers and Contractors and a union representative of employees of Toledo Edison Company, working on site at the power station, to evaluate employee skin and scalp problems due to exposure to ceramic wood fibers. Preliminary surveys were conducted on September 24 and 25, 1980 and a follow-up survey was performed on October 16, 1980. Environmental evaluation consisted of gravimetric analyses of personal air samples for airbornemore » ceramic wool fibers. A total of 400 production and maintenance workers and varying numbers of construction workers were exposed to the fibers during installation of insulation which was completed at the time of the survey. The three personal air samples showed no accumulation of particulates and fibers detected were nonrespirable. Medical evaluations were conducted in 52 workers and scalp scrapings were obtained from 43 workers. Thirty seven workers had histories suggestive of irritant dermatitis of the scalp; 24 workers had physical findings consistent with the diagnosis. Of the 43 scalp samples, 18 were contaminated with organisms of the gut, perineum, skin or respiratory tract. Dermatitis was directly related to the history of dust exposure. The authors conclude that a potential health hazard exists for employees from exposure to ceramic wool fiber. Recommendations include provision of handwashing facilities and protective clothing for employees, and installation of an impermeable covering for the ceramic wool fiber.« less

A Novel Event-Based Incipient Slip Detection Using Dynamic Active-Pixel Vision Sensor (DAVIS)

PubMed Central

Rigi, Amin

2018-01-01

In this paper, a novel approach to detect incipient slip based on the contact area between a transparent silicone medium and different objects using a neuromorphic event-based vision sensor (DAVIS) is proposed. Event-based algorithms are developed to detect incipient slip, slip, stress distribution and object vibration. Thirty-seven experiments were performed on five objects with different sizes, shapes, materials and weights to compare precision and response time of the proposed approach. The proposed approach is validated by using a high speed constitutional camera (1000 FPS). The results indicate that the sensor can detect incipient slippage with an average of 44.1 ms latency in unstructured environment for various objects. It is worth mentioning that the experiments were conducted in an uncontrolled experimental environment, therefore adding high noise levels that affected results significantly. However, eleven of the experiments had a detection latency below 10 ms which shows the capability of this method. The results are very promising and show a high potential of the sensor being used for manipulation applications especially in dynamic environments. PMID:29364190

Effect of benzene, toluene, ethylbenzene, and p-xylene (BTEX) mixture on biodegradation of methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA) by pure culture UC1.

PubMed

Pruden, Amy; Suidan, Makram

2004-08-01

The effect of a BTEX mixture on the biodegradation of methyl tert-butyl ether (MTBE) and its degradation intermediate, tert-butyl alcohol (TBA) was investigated in the pure bacterial culture UC1, which has been identified to be a strain of the known MTBE-degrader PM1 based on greater than 99% 16S rDNA similarity. Several degradation studies were carried out on UC1 at three initial concentration levels of MTBE or TBA: 6-7; 15-17; and 40-45 mg/l, both with and without BTEX present cumulatively at about half of the MTBE or TBA molar mass in the system. The BTEX mixture was observed not to affect either the rate or the degradation lag period of MTBE or TBA degradation, except that the TBA degradation rate actually increased when BTEX was present initially in the highest concentration studies. When serving as the sole substrate, the MTBE degradation rate ranged from 48 +/- 1.2 to 200 +/- 7.0 mg(MTBE)/g(dw) h, and the TBA degradation rate from 140 +/- 18 to 530 +/- 70 mg(TBA)/g(dw) h. When present with BTEX, MTBE and TBA rates ranged from 46 +/- 2.2 to 210 +/- 14 and 170 +/- 28 to 780 +/- 43 mg(TBA)/g(dw) h, respectively. In studies where varying concentrations of TBA were present with 5 mg/l MTBE, both compounds were degraded simultaneously with no obvious preference for either substrate. In the highest concentration study of TBA with 5 mg/l MTBE, BTEX was also observed to increase the ultimate rate of TBA degradation. In addition to exploring the affect of BTEX, this study also provides general insight into the metabolism of MTBE and TBA by pure culture UC1.

Clinical relevance of endoscopic assessment of inflammation in ulcerative colitis: Can endoscopic evaluation predict outcomes?

PubMed Central

Mohammed, Noor; Subramanian, Venkataraman

2016-01-01

Ulcerative colitis (UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic inflammation. Current evidence suggests that presence of histological inflammation poses a greater risk of disease relapse and subsequent colorectal cancer risk. New endoscopic technologies hold promise for developing endoscopic markers of mucosal inflammation. Achieving endoscopic and histological remission appears be the future aim of medical treatments for UC. This review article aims to evaluate the use of endoscopy as a tool in assessment of mucosal inflammation UC and its correlation with disease outcomes. PMID:27895420

Final Environmental Assessment and Finding of No Significant Impact (EA/FONSI) for 2012-14 Capital Improvements Program (CIP) at Davis-Monthan Air Force Base, Tucson, Arizona

DTIC Science & Technology

2012-03-01

3553 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) US Air Force, Davis-Monthan AFB 355 CES/CEAO...would be insignificant. Operational impacts, including the use of groundwater for water supply, would be similar to current conditions. Biological...expected in the vicinity of the hush house. Land Use and Visual Resources. Construction and demolition activities would create temporary land use

Geographic List of Prime Contract Awards. Oct 92-Sep 93. FY 93. (Ada, Ohio-York County, Penn). Part 10

DTIC Science & Technology

1994-03-01

5 ARLINGTON, VA 22202-4302 "’APR 0 6 1994 STATMENT A, DISTRIBUTION UNLIMITED, PER MS. JACKIE DAVIS WASHINGTON...HEADQUARTERS SERVICES ARLINGTON, VA. A 94-10329 ඦ 4 5 N014 639 UC (A In4 c Co.::C w (D 4-00- a . 0 ) 03W o3 41 CLOL: 0 U S 0 . -~’ 0 ’ 0 .w 4- I-u CLW41 CI co M (u...U 0 ) U - -03Ca) C 0j0 a) 0 4 ’’ m a) fe - - U1 - 0 Lo w3 4-. Q) UL a 0 c c M 4J 4 M [I 4 S- +1- 5 ’ V3 U, It

Terms and conditions for Diesel Emissions Reduction Act Smartway financing projects where an eligible nonprofit grantee is implementing a loan program and loan Recipients will use the loan funds for activities that trigger Davis Bacon

EPA Pesticide Factsheets

Use this T&C for DERA Smartway financing projects where an eligible nonprofit grantee is implementing a loan program and loan Recipients will use the loan funds for activities that trigger Davis Bacon.

Indentifying environmental features for land management decisions. [Uinta Basin, Davis County foothills, and Farmington Bay in Utah

NASA Technical Reports Server (NTRS)

1980-01-01

The wetlands and water-related land use in the Uinta Basin were classified and mapped using photointerpretation of U-2 infrared photography and digital LANDSAT data. The digital maps were used to augment photointerpretations. A highly effective diagnostic tool emerged when the LANDSAT digital print was photoreduced to a film positive at the same scale as the U-2 film and overlain on the U-2 color film. As a result of this merging technique, cover types can be identified more accurately and probablistic statements can be made about the relative amounts of water being consumed in one pasture vs. another. The hazards to urban development on sensitive and unstable land in the foothills of Davis County were studied using NASA U-2 photography. Shoreline fluctuations were mapped in the Farmington Bay using LANDSAT digital data.

Geology of the Joe Davis Hill quadrangle, Dolores and San Miguel counties, Colorado

USGS Publications Warehouse

Cater, Fred W.; Bell, Henry

1953-01-01

The Joe Davis Hill quadrangle is one of eighteen 7 1/2-minute quadrangles covering the principal carnotite-producing area of southwestern Colorado. The geology of these quadrangles was mapped by the U.S. Geological Survey for the Atomic Energy Commission as part of a comprehensive study of carnotite deposits. The rocks exposed in the eighteen quadrangles consist of crystalline rocks of pre-Cambrian age and sedimentary rocks that range in age from late Paleozoic to Quaternary. Over much of the area the sedimentary rocks are flat lying, but in places the rocks are disrupted by hih-angle faults, and northwest-trending folds. Conspicuous among the folds are large anticlines having cores of intrusive salt and gypsum. Most of the carnotite deposits are confined to Salt Wash sandstone member of the Jurassic Morrison formation. Within this sandstone, most of the deposits are spottily distributed through an arcuate zone known as the "Uravan Mineral Belt". Individual deposits range in size from irregular masses containing only a few tons of ore to large, tabular masses containing many thousands of tons. The ore consists largely of sandstone selectively impregnated and in part replaced by uranium and vanadium minerals. Most of the deposits appear to be related to certain sedimentary structures in sandstones of favorable composition.

Thinking regionally: narrative, the medical humanities and region.

PubMed

Waddington, Keir

2015-06-01

Drawing on multiple literatures from history, geography, anthropology, sociology and literature, this essay asks questions about what we mean by region and why narratives of region should matter to the medical humanities. The essay surveys how region can be used as a lens of analysis, exploring the various academic approaches to region and their limitations. It argues that regions are dynamic but also unstable as a category of analysis and are often used uncritically by scholars. In encouraging scholars working in the medical humanities to be aware that regions are not simple objective or analytical boxes, the essay shows how an awareness of region helps challenge metropolitan whiggism and ideas of core and periphery to give a more prominent place to hinterlands, market towns and rural environments. Furthermore, the essay considers how incorporating region into our understanding of illness can offer new insights. It demonstrates the need for scholars to be attuned to the narratives constructed around regions, suggesting that regions can be viewed as discursive formations that provide a frame for understanding both collective and personal ideas of, and responses to, health and illness, disease and healing, to create what Megan Davies calls a more nuanced 'intellectual cartography'. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Design and Implementation of Davis Social Links OSN Kernel

NASA Astrophysics Data System (ADS)

Tran, Thomas; Chan, Kelcey; Ye, Shaozhi; Bhattacharyya, Prantik; Garg, Ankush; Lu, Xiaoming; Wu, S. Felix

Social network popularity continues to rise as they broaden out to more users. Hidden away within these social networks is a valuable set of data that outlines everyone’s relationships. Networks have created APIs such as the Facebook Development Platform and OpenSocial that allow developers to create applications that can leverage user information. However, at the current stage, the social network support for these new applications is fairly limited in its functionality. Most, if not all, of the existing internet applications such as email, BitTorrent, and Skype cannot benefit from the valuable social network among their own users. In this paper, we present an architecture that couples two different communication layers together: the end2end communication layer and the social context layer, under the Davis Social Links (DSL) project. Our proposed architecture attempts to preserve the original application semantics (i.e., we can use Thunderbird or Outlook, unmodified, to read our SMTP emails) and provides the communicating parties (email sender and receivers) a social context for control and management. For instance, the receiver can set trust policy rules based on the social context between the pair, to determine how a particular email in question should be prioritized for delivery to the SMTP layer. Furthermore, as our architecture includes two coupling layers, it is then possible, as an option, to shift some of the services from the original applications into the social context layer. In the context of email, for example, our architecture allows users to choose operations, such as reply, reply-all, and forward, to be realized in either the application layer or the social network layer. And, the realization of these operations under the social network layer offers powerful features unavailable in the original applications. To validate our coupling architecture, we have implemented a DSL kernel prototype as a Facebook application called CyrusDSL (currently about

Stability and change in retrospective reports of childhood experiences over a 5-year period: findings from the Davis Longitudinal Study.

PubMed

Yancura, Loriena A; Aldwin, Carolyn M

2009-09-01

The paths via which childhood experiences influence well-being in adulthood are not well defined because most research relies on retrospective reports. This study examined the influence of demographic characteristics and current mood states on the reliability of reports of childhood experiences. The Child Experiences Scale (CES) was administered in 1996 and 2001 to participants in the Davis Longitudinal Study (N = 571; age range 22-61 years). Responses showed moderate to high cross-time reliability. Males were slightly more likely to change their responses. The influence of mood states was weak and more evident for global ratings of childhood than for specific experiences. These findings support the use of retrospective reports of childhood. (c) 2009 APA, all rights reserved.

The Women in Medicine and Health Science program: an innovative initiative to support female faculty at the University of California Davis School of Medicine.

PubMed

Bauman, Melissa D; Howell, Lydia P; Villablanca, Amparo C

2014-11-01

Although more female physicians and scientists are choosing careers in academic medicine, women continue to be underrepresented as medical school faculty, particularly at the level of full professor and in leadership positions. Effective interventions to support women in academic medicine exist, but the nature and content of such programs varies widely. Women in medicine programs can play a critical role in supporting women's careers and can improve recruitment and retention of women by providing opportunities for networking, sponsorship, mentorship, and career development. The University of California Davis School of Medicine established the Women in Medicine and Health Science (WIMHS) program in 2000 to ensure the full participation and success of women in all roles within academic medicine. The authors describe the components and evolution of the WIMHS program. A steady increase in the number and percentage of female faculty and department chairs, as well as a relatively low departure rate for female faculty, strong and growing internal partnerships, and enthusiastic support from faculty and the school of medicine leadership, suggest that the WIMHS program has had a positive influence on recruitment and retention, career satisfaction, and institutional climate to provide a more inclusive and supportive culture for women. Going forward, the WIMHS program will continue to advocate for broader institutional change to support female faculty, like creating an on-site child care program. Other institutions seeking to address the challenges facing female faculty may consider using the WIMHS program as a model to guide their efforts.

Adaptive optics ophthalmologic systems using dual deformable mirrors

NASA Astrophysics Data System (ADS)

Jones, S. M.; Olivier, S.; Chen, D.; Joeres, S.; Sadda, S.; Zawadzki, R. J.; Werner, J. S.; Miller, D. T.

2007-02-01

Adaptive Optics (AO) have been increasingly combined with a variety of ophthalmic instruments over the last decade to provide cellular-level, in-vivo images of the eye. The use of MEMS deformable mirrors in these instruments has recently been demonstrated to reduce system size and cost while improving performance. However, currently available MEMS mirrors lack the required range of motion for correcting large ocular aberrations, such as defocus and astigmatism. In order to address this problem, we have developed an AO system architecture that uses two deformable mirrors, in a woofer / tweeter arrangement, with a bimorph mirror as the woofer and a MEMS mirror as the tweeter. This setup provides several advantages, including extended aberration correction range, due to the large stroke of the bimorph mirror, high order aberration correction using the MEMS mirror, and additionally, the ability to 'focus' through the retina. This AO system architecture is currently being used in four instruments, including an Optical Coherence Tomography (OCT) system and a retinal flood-illuminated imaging system at the UC Davis Medical Center, a Scanning Laser Ophthalmoscope (SLO) at the Doheny Eye Institute, and an OCT system at Indiana University. The design, operation and evaluation of this type of AO system architecture will be presented.

Avoidable iatrogenic complications of male urethral catheterisation and inadequate intern training: a 4-year follow-up post implementation of an intern training programme.

PubMed

Sullivan, J F; Forde, J C; Thomas, A Z; Creagh, T A

2015-02-01

To assess the impact of a structured training programme in urethral catheterisation (UC) targeted at newly qualified junior doctors on rates of iatrogenic catheter morbidity within a tertiary care referral centre. Male UC-related morbidities were retrospectively identified from our computerised inpatient urology consultation system over a 1-year period from July 2010 to June 2011. Relevant medical records were also reviewed. Results were compared with an initial study performed between July 2006 and June 2007, prior the introduction of a structured training programme in our institution. An anonymous questionnaire was used for the subjective assessment of interns about confidence in catheterising post introduction of the programme. Of 725 urological consultations, 29 (4%) were related to complications arising from male UC during the 1 year period. This reflected a statistically significant decrease when compared to our 2007 figures, 51/864 (6%) (p < 0.05). Again, the most common indication for UC was monitoring urinary output for acute medical illness (19/29, 66%). The most common complication was urethral trauma (16/29, 55%). Of the 29 cases of UC-related morbidity, 18 (62%) resulted from interns performing UC, a decrease of 12% from our original paper. A drop of 27% was seen in the rates of UC related morbidity attributable to interns during the first 6 months of internship (July-December). Overall, 70% (vs 40% original study) of interns felt that their practical training was adequate since introduction of the programme (p < 0.01) with 53% considering theoretical training adequate (vs 16% original study (p < 0.01). When asked were they confident in performing UC, 63% said they were compared to 35% before introduction of the programme (p < 0.05). UC-related iatrogenic morbidity is not uncommon even in a tertiary-care teaching hospital. Implementation of a structured training programme in UC prior to the commencement of intern year has been shown to result

Role of sex in the treatment and clinical outcomes of pediatric patients with inflammatory bowel disease.

PubMed

Lee, Grace J; Kappelman, Michael D; Boyle, Brendan; Colletti, Richard B; King, Eileen; Pratt, Jesse M; Crandall, Wallace V

2012-12-01

To examine sex differences in medical therapy and clinical outcomes in pediatric patients with inflammatory bowel disease (IBD). We performed a cross-sectional analysis of children with Crohn disease (CD) and ulcerative colitis (UC) using data from the ImproveCareNow Network collected between May 2007 and May 2010. Clinical remission, disease severity, body mass index (BMI) z scores, normal height velocity, and medication use were analyzed by sex and age. One thousand four hundred nine patients were included (993 had CD and 416 had UC). No significant sex differences were found in disease severity, BMI, height velocity, or use of medications. Further analysis of combination therapy with infliximab + 6-mercaptopurine/azathioprine and infliximab + methotrexate also did not reveal any differences. No sex differences were found after mediation use was stratified by age (those younger than 13 years and those 13 years old or older). In this sample of CD and UC pediatric patients, no significant sex differences were found in disease severity, BMI, height velocity, or medication use. Our data do not support the use of sex as a major factor in patient risk stratification for children with IBD. In addition, despite concerns for sex-specific complications of some medications, our analysis did not suggest any sex differences in medication use.

Managing ulcerative colitis in remission phase: usefulness of Casperome®, an innovative lecithin-based delivery system of Boswellia serrata extract.

PubMed

Pellegrini, L; Milano, E; Franceschi, F; Belcaro, G; Gizzi, G; Feragalli, B; Dugall, M; Luzzi, R; Togni, S; Eggenhoffner, R; Giacomelli, L

2016-06-01

Boswellia serrata extracts (BSE) have been traditionally used for the treatment of several inflammatory diseases. The aim of this study was to evaluate the efficacy of a novel delivery form of BSE (Casperome®) in Ulcerative Colitis (UC) during minimally symptomatic remission phase. In this open-label, observational, registry study, informed participants with UC in remission phase (n = 43) freely decided to receive the oral daily Casperome® supplementation (n = 22) or no supplementation (n = 21) for 4 weeks. Several parameters associated with minimally symptomatic UC in remission were evaluated at the inclusion and the end of the study. A significant beneficial effect of Casperome® was observed for all the parameters evaluated, namely: diffuse intestinal pain, evident and occult blood in stools, bowel movements and cramps, watery stools, malaise, anemia, rectal involvement, number of white blood cells as well as need for concomitant drugs and medical attention. Faecal concentration of calprotectin, a marker of bowel inflammation, resulted ameliorated in Casperome® supplemented patients. Our study showed that Casperome® supplementation attenuates symptoms associated with mild UC in remission, reducing the use of drugs and medical consultations. Therefore, our study suggests that Casperome® supplementation could represent a promising alternative approach to manage minimally symptomatic UC and maintain the remission phase.

New Cooperative Agreement Supports Training for Healthcare Providers on Pesticide-Related Health Conditions

EPA Pesticide Factsheets

EPA has awarded a cooperative agreement, Pesticide Education for Medical Professionals, to the University of California Davis Extension to educate the medical community on how to prevent, recognize and treat pesticide-related health conditions.

Eckert and Davis Grade 3 Superior Peroneal Retinaculum Injury: Treated by Endoscopic Peroneal Retinaculum Reconstruction and Complicated by Malposition of the Suture Anchors.

PubMed

Lui, T H

2015-01-01

Eckert and Davis grade 3 superior peroneal retinaculum injury is rare and the optimal treatment is not yet determined. A 57 year-old lady sprained her left ankle resulting in grade 3 injury of the superior peroneal retinaculum and was treated by endoscopic retinaculum reconstruction. The fracture healed and the peroneal tendons were stabilized. However, it was complicated by protusion of the suture anchors into the posterolateral ankle gutter. The implants were successfully removed endoscopically. Proper selection of the size and dimension of the suture anchor and preoperative planning with computed tomogram is important for usage of suture anchors in the lateral malleolus.

Photochemical methods to assay DNA photocleavage using supercoiled pUC18 DNA and LED or xenon arc lamp excitation.

PubMed

Prussin, Aaron J; Zigler, David F; Jain, Avijita; Brown, Jared R; Winkel, Brenda S J; Brewer, Karen J

2008-04-01

Methods for the study of DNA photocleavage are illustrated using a mixed-metal supramolecular complex [{(bpy)(2)Ru(dpp)}(2)RhCl(2)]Cl(5). The methods use supercoiled pUC18 plasmid as a DNA probe and either filtered light from a xenon arc lamp source or monochromatic light from a newly designed, high-intensity light-emitting diode (LED) array. Detailed methods for performing the photochemical experiments and analysis of the DNA photoproduct are delineated. Detailed methods are also given for building an LED array to be used for DNA photolysis experiments. The Xe arc source has a broad spectral range and high light flux. The LEDs have a high-intensity, nearly monochromatic output. Arrays of LEDs have the advantage of allowing tunable, accurate output to multiple samples for high-throughput photochemistry experiments at relatively low cost.

Ulcerative colitis-associated hospitalization costs: A population-based study

PubMed Central

Coward, Stephanie; Heitman, Steven J; Clement, Fiona; Hubbard, James; Proulx, Marie-Claude; Zimmer, Scott; Panaccione, Remo; Seow, Cynthia; Leung, Yvette; Datta, Neel; Ghosh, Subrata; Myers, Robert P; Swain, Mark; Kaplan, Gilaad G

2015-01-01

BACKGROUND: Hospitalization costs for ulcerative colitis (UC) following the introduction of infliximab have not been evaluated. OBJECTIVE: To study predictors of costs for UC patients who were hospitalized for a flare or colectomy. METHODS: Population-based surveillance identified adults (≥18 years of age) admitted to hospital for UC flare or colectomy between 2001 and 2009 in the Calgary Health Zone (Alberta). Medical charts were reviewed and patients stratified into three admission types: responsive to inpatient medical therapy (n=307); emergent colectomy (n=227); and elective colectomy (n=208). The annual median cost with interquartile range (IQR) was calculated. Linear regression determined the effect of admission type on hospital charges after adjusting for age, sex, smoking, comorbidities, disease extent, medication use (eg, infliximab) and year. The adjusted cost increase was presented as the percent increase with 95% CIs. Joinpoint analysis assessed for an inflection point in hospital cost after the introduction of infliximab. RESULTS: Median hospitalization cost for UC flare, emergent colectomy and elective colectomy, respectively, were: $5,499 (IQR $3,374 to $8,904), $23,698 (IQR $17,981 to $32,385) and $14,316 (IQR $11,932 to $18,331). Adjusted hospitalization costs increased approximately 6.0% annually (95% CI 4.5% to 7.5%). Adjusted costs were higher for patients who underwent an elective colectomy (percent increase cost 179.8% [95% CI 151.6% to 211.1%]) or an emergent colectomy (percent increase cost 211.1% [95% CI 183.2% to 241.6%]) than medically responsive patients. Infliximab in hospital was an independent predictor of increased costs (percent increase cost 69.5% [95% CI 49.2% to 92.5%]). No inflection points were identified. CONCLUSION: Hospitalization costs for UC increased due to colectomy and infliximab. PMID:26079072

Report on the Program "Fluid-mediated particle transport in geophysical flows" at the Kavli Institute for Theoretical Physics, UC Santa Barbara, September 23 to December 12, 2013

NASA Astrophysics Data System (ADS)

Jenkins, James T.; Meiburg, Eckart; Valance, Alexandre

2015-09-01

The Kavli Institute of Theoretical Physics (KITP) program held at UC Santa Barbara in the fall of 2013 addressed the dynamics of dispersed particulate flows in the environment. By focusing on the prototypes of aeolian transport and turbidity currents, it aimed to establish the current state of our understanding of such two-phase flows, to identify key open questions, and to develop collaborative research strategies for addressing these questions. Here, we provide a brief summary of the program outcome.

Characterization and Mapping of Leaf Rust and Stripe Rust Resistance Loci in Hexaploid Wheat Lines UC1110 and PI610750 under Mexican Environments.

PubMed

Lan, Caixia; Hale, Iago L; Herrera-Foessel, Sybil A; Basnet, Bhoja R; Randhawa, Mandeep S; Huerta-Espino, Julio; Dubcovsky, Jorge; Singh, Ravi P

2017-01-01

Growing resistant wheat varieties is a key method of minimizing the extent of yield losses caused by the globally important wheat leaf rust (LR) and stripe rust (YR) diseases. In this study, a population of 186 F 8 recombinant inbred lines (RILs) derived from a cross between a synthetic wheat derivative (PI610750) and an adapted common wheat line (cv. "UC1110") were phenotyped for LR and YR response at both seedling and adult plant stages over multiple seasons. Using a genetic linkage map consisting of single sequence repeats and diversity arrays technology markers, in combination with inclusive composite interval mapping analysis, we detected a new LR adult plant resistance (APR) locus, QLr.cim-2DS , contributed by UC1110. One co-located resistance locus to both rusts, QLr.cim-3DC/QYr.cim-3DC , and the known seedling resistance gene Lr26 were also mapped. QLr.cim-2DS and QLr.cim-3DC showed a marginally significant interaction for LR resistance in the adult plant stage. In addition, two previously reported YR APR loci, QYr.ucw-3BS and Yr48 , were found to exhibit stable performances in rust environments in both Mexico and the United States and showed a highly significant interaction in the field. Yr48 was also observed to confer intermediate seedling resistance against Mexican YR races, thus suggesting it should be re-classified as an all-stage resistance gene. We also identified 5 and 2 RILs that possessed all detected YR and LR resistance loci, respectively. With the closely linked molecular markers reported here, these RILs could be used as donors for multiple resistance loci to both rusts in wheat breeding programs.

Preparation of UC0.07-0.10N0.90-0.93 spheres for TRISO coated fuel particles

NASA Astrophysics Data System (ADS)

Hunt, R. D.; Silva, C. M.; Lindemer, T. B.; Johnson, J. A.; Collins, J. L.

2014-05-01

The US Department of Energy is considering a new nuclear fuel that would be less susceptible to ruptures during a loss-of-coolant accident. The fuel would consist of tristructural isotropic coated particles with dense uranium nitride (UN) kernels with diameters of 650 or 800 μm. The objectives of this effort are to make uranium oxide microspheres with adequately dispersed carbon nanoparticles and to convert these microspheres into UN spheres, which could be then sintered into kernels. Recent improvements to the internal gelation process were successfully applied to the production of uranium gel spheres with different concentrations of carbon black. After the spheres were washed and dried, a simple two-step heat profile was used to produce porous microspheres with a chemical composition of UC0.07-0.10N0.90-0.93. The first step involved heating the microspheres to 2023 K in a vacuum, and in the second step, the microspheres were held at 1873 K for 6 h in flowing nitrogen.

The Women in Medicine and Health Science Program: An Innovative Initiative to Support Female Faculty at the University of California Davis School of Medicine

PubMed Central

Bauman, Melissa D.; Howell, Lydia P.; Villablanca, Amparo C.

2014-01-01

Problem Although more female physicians and scientists are choosing careers in academic medicine, women continue to be underrepresented as medical school faculty, particularly at the level of full professor and in leadership positions. Effective interventions to support women in academic medicine exist, but the nature and content of such programs varies widely. Approach Women in medicine programs can play a critical role in supporting women’s careers and can improve recruitment and retention of women by providing opportunities for networking, sponsorship, mentorship, and career development. The University of California Davis School of Medicine established the Women in Medicine and Health Science (WIMHS) program in 2000 to ensure the full participation and success of women in all roles within academic medicine. The authors describe the components and evolution of the WIMHS program. Outcomes A steady increase in the number and percentage of female faculty and department chairs, as well as a relatively low departure rate for female faculty, strong and growing internal partnerships, and enthusiastic support from faculty and the school of medicine leadership, suggest that the WIMHS program has had a positive influence on recruitment and retention, career satisfaction, and institutional climate to provide a more inclusive and supportive culture for women. Next steps Going forward, the WIMHS program will continue to advocate for broader institutional change to support female faculty, like creating an onsite childcare program. Other institutions seeking to address the challenges facing female faculty may consider using the WIMHS program as a model to guide their efforts. PMID:25006704

Building America Case Study: Multifamily Central Heat Pump Water Heaters, Davis, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Although heat pump water heaters (HPWHs) have gained significant attention in recent years as a high efficiency electric water heating solution for single family homes, central HPWHs for commercial or multi-family applications are not as well documented in terms of measured performance and cost effectiveness. To evaluate this technology, the Alliance for Residential Building Innovation team monitored the performance of a 10.5 ton central HPWH installed on a student apartment building at the West Village Zero Net Energy Community in Davis, California. Monitoring data collected over a 16-month period were then used to validate a TRNSYS simulation model. The TRNSYSmore » model was then used to project performance in different climates using local electric rates. Results of the study indicate that after some initial commissioning issues, the HPWH operated reliably with an annual average efficiency of 2.12 (Coefficient of Performance). The observed efficiency was lower than the unit's rated efficiency, primarily due to the fact that the system rarely operated under steady-state conditions. Changes in the system configuration, storage tank sizing, and control settings would likely improve the observed field efficiency. Modeling results suggest significant energy savings relative to electric storage water heating systems (typical annual efficiencies around 0.90) providing for typical simple paybacks of six to ten years without any incentives. The economics versus gas water heating are currently much more challenging given the current low natural gas prices in much of the country. Increased market size for this technology would benefit cost effectiveness and spur greater technology innovation.« less

An assessment of scientific and technical aspects of closed investigations of canine forensics DNA--case series from the University of California, Davis, USA.

PubMed

Scharnhorst, Günther; Kanthaswamy, Sree

2011-06-01

To describe and assess the scientific and technical aspects of animal forensic testing at the University of California, Davis. The findings and recommendations contained in this report are designed to assess the past, evaluate the present, and recommend reforms that will assist the animal forensic science community in providing the best possible services that comply with court standards and bear judicial scrutiny. A batch of 32 closed files of domestic dog DNA cases processed at the University of California, Davis, between August 2003 and July 2005 were reviewed in this study. The case files comprised copies of all original paperwork, copies of the cover letter or final report, laboratory notes, notes on analyses, submission forms, internal chains of custody, printed images and photocopies of evidence, as well as the administrative and technical reviews of those cases. While the fundamental aspects of animal DNA testing may be reliable and acceptable, the scientific basis for forensic testing animal DNA needs to be improved substantially. In addition to a lack of standardized and validated genetic testing protocols, improvements are needed in a wide range of topics including quality assurance and quality control measures, sample handling, evidence testing, statistical analysis, and reporting. This review implies that although a standardized panel of short tandem repeat and mitochondrial DNA markers and publicly accessible genetic databases for canine forensic DNA analysis are already available, the persistent lack of supporting resources, including standardized quality assurance and quality control programs, still plagues the animal forensic community. This report focuses on closed cases from the period 2003-2005, but extends its scope more widely to include other animal DNA forensic testing services.

Expanding the Graduate Education Experience at Scripps Institution of Oceanography, UC San Diego

NASA Astrophysics Data System (ADS)

Peach, C. L.; Kilb, D. L.; Zmarzly, D.; Abeyta, E.

2016-02-01

Emerging career pathways for graduate students in earth, ocean and climate sciences increasingly require skills in teaching and communication. This is true of academic careers, in which demonstrated teaching skills make applicants for faculty positions far more competitive, and traditionally less conventional careers outside of academia that require cross-disciplinary collaboration and/or communication to audiences not directly involved in science research (e.g. policy makers, educators, the public). Yet most graduate education programs provide little to no opportunity or incentive for young investigators to develop and hone these skills, and graduate students are often discouraged from deviating from the traditional "research apprenticeship" model during their graduate education. At Scripps, the Birch Aquarium at Scripps, and UC San Diego Extension, we are developing new ways to integrate teaching, communication, and outreach into our graduate education program, thus broadening the scope of graduate training and better serving the needs and evolving career aspirations of our graduate students. This effort is an integral part of our overall outreach strategy a Scripps in which we seek to combine high quality STEM outreach and teaching with opportunities for Scripps graduate students to put their teaching and communications training into practice. The overall effort is a "win-win" both for our students and for the highly diverse K-16 community in San Diego County. In this talk we will summarize the programmatic efforts currently underway at Scripps, our strategic collaboration with UCSD Extension, which is expanding the capacity and reach of our integrated program, and our plans for sustaining these efforts for the long term.

Assessing medical students' attitudes towards learning communication skills--which components of attitudes do we measure?

PubMed

Anvik, Tor; Gude, Tore; Grimstad, Hilde; Baerheim, Anders; Fasmer, Ole B; Hjortdahl, Per; Holen, Are; Risberg, Terje; Vaglum, Per

2007-03-30

The Communication Skills Attitudes Scale (CSAS) created by Rees, Sheard and Davies and published in 2002 has been a widely used instrument for measuring medical students' attitudes towards learning communication skills. Earlier studies have shown that the CSAS mainly tests two dimensions of attitudes towards communication; positive attitudes (PAS) and negative attitudes (NAS). The objectives of our study are to explore the attitudes of Norwegian medical students towards learning communication skills, and to compare our findings with reports from other countries. The CSAS questionnaire was mailed simultaneously to all students (n = 3055) of the four medical schools in Norway in the spring of 2003. Response from 1833 students (60.0%) were analysed by use of SPSS ver.12. A Principal component analysis yielded findings that differ in many respects from those of earlier papers. We found the CSAS to measure three factors. The first factor describes students' feelings about the way communication skills are taught, whereas the second factor describes more fundamental attitudes and values connected to the importance of having communication skills for doctors. The third factor explores whether students feel that good communication skills may help them respecting patients and colleagues. Our findings indicate that in this sample the CSAS measures broader aspects of attitudes towards learning communication skills than the formerly described two-factor model with PAS and NAS. This may turn out to be helpful for monitoring the effect of different teaching strategies on students' attitudes during medical school.

Second Korean guidelines for the management of ulcerative colitis

PubMed Central

Choi, Chang Hwan; Moon, Won; Kim, You Sun; Kim, Eun Soo; Lee, Bo-In; Jung, Yunho; Yoon, Yong Sik; Lee, Heeyoung; Park, Dong Il

2017-01-01

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during exacerbation of the disease. The incidence and prevalence of UC in Korea are still lower than those of Western countries, but have been rapidly increasing during the past decades. Various medical and surgical therapies, including biologics, are currently used for the management of UC. However, many challenging issues exist, which sometimes lead to differences in practice between clinicians. Therefore, the IBD study group of the Korean Association for the Study of Intestinal Diseases established the first Korean guidelines for the management of UC in 2012. This is an update of the first guidelines. It was generally made by the adaptation of several foreign guidelines as was the first edition, and encompasses treatment of active colitis, maintenance of remission, and indication of surgery for UC. The specific recommendations are presented with the quality of evidence and classification of recommendations. PMID:28239313

Report on the Program “Fluid-mediated particle transport in geophysical flows” at the Kavli Institute for Theoretical Physics, UC Santa Barbara, September 23 to December 12, 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jenkins, James T.; Meiburg, Eckart; Valance, Alexandre

2015-09-15

The Kavli Institute of Theoretical Physics (KITP) program held at UC Santa Barbara in the fall of 2013 addressed the dynamics of dispersed particulate flows in the environment. By focusing on the prototypes of aeolian transport and turbidity currents, it aimed to establish the current state of our understanding of such two-phase flows, to identify key open questions, and to develop collaborative research strategies for addressing these questions. Here, we provide a brief summary of the program outcome.

Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease.

PubMed

Romberg-Camps, M J L; Dagnelie, P C; Kester, A D M; Hesselink-van de Kruijs, M A M; Cilissen, M; Engels, L G J B; Van Deursen, C; Hameeteman, W H A; Wolters, F L; Russel, M G V M; Stockbrügger, R W

2009-02-01

Disease course in inflammatory bowel disease (IBD) is variable and difficult to predict. To optimize prognosis, it is of interest to identify phenotypic characteristics at disease onset and other prognostic factors that predict disease course. The aim of this study was to evaluate such factors in a population-based IBD group. IBD patients diagnosed between 1 January 1991 and 1 January 2003 were included. A follow-up questionnaire was developed and medical records were reviewed. Patients were classified according to phenotype at diagnosis and risk factors were registered. Disease severity, cumulative medication use, and "surgical" and "nonsurgical" recurrence rates were calculated as outcome parameters. In total, 476 Crohn's disease (CD), 630 ulcerative colitis (UC), and 81 indeterminate colitis (IC) patients were diagnosed. In CD (mean follow-up 7.6 years), 50% had undergone resective surgery. In UC (mean follow-up 7 years), colectomy rate was 8.3%. First year cumulative recurrence rates per 100 patient-years for CD, UC, and IC were 53, 44, and 42%, respectively. In CD, small bowel localization and stricturing disease were negative prognostic factors for surgery, as was young age. Overall recurrence rate was increased by young age and current smoking. In UC, extensive colitis increased surgical risk. In UC, older age at diagnosis initially increased recurrence risk but was subsequently protective. This population-based IBD study showed high recurrence rates in the first year. In CD, small bowel localization, stricturing disease, and young age were predictive for disease recurrence. In UC, extensive colitis and older age at diagnosis were negative prognostic predictors.

[Urinary catheters prevalence study in a university hospital].

PubMed

Carrouget, J; Legeay, C; Poirier, A; Azzouzi, A-R; Zahar, J-R; Bigot, P

2017-04-01

Urinary tract infection is the most common healthcare-association infection, especially because of urinary catheter. We evaluated our practices concerning catheter insertion and management in our institution. We conducted a single-centre descriptive cross-sectional study during 1 week in September 2014 in all adult departments. We noted prevalence, indications, length, management of urinary catheter (UC) and symptomatic catheter-associated urinary tract infections (SCAUTI). Amongst 1046 patients audited, 125 (12%) had UC. The mean age was 72 years (64.8-79.2). UC prevalence was higher in surgical (88%) and medical (87%) intensive care, urology (50%), geriatrics (18%) and long-term care (18%) departments. The average catheterisation length was 7.8 days (3.8-11.8); it was shorter in surgery than in medicine departments (3.6 vs 9.7 days, P<0.001). Catheters were present for more than 4 days in 60% of the cases. Acute urinary retention was the most frequent indication (59%), significantly more in medical than surgical departments (75% vs 26%). Others indications were perioperative (17%), diuresis monitoring (12%), strict immobilization (4%) and unnecessary indications or staff comfort (4%). A SCAUTI was present in 10% of cases, mostly in medicine department (30% vs 8%). The prevalence of our institution is higher than the national prevalence (8.1%), but still below the European average (17.2%). Control of the risk of CAUTI requires compliance with UC appropriate indications, UC management, and prompt removal of unnecessary UC. 4. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]).

PubMed

Bartolucci, Jorge; Verdugo, Fernando J; González, Paz L; Larrea, Ricardo E; Abarzua, Ema; Goset, Carlos; Rojo, Pamela; Palma, Ivan; Lamich, Ruben; Pedreros, Pablo A; Valdivia, Gloria; Lopez, Valentina M; Nazzal, Carolina; Alcayaga-Miranda, Francisca; Cuenca, Jimena; Brobeck, Matthew J; Patel, Amit N; Figueroa, Fernando E; Khoury, Maroun

2017-10-27

Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. Although bone marrow-derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has evaluated intravenous infusion of UC-MSCs in these patients. Evaluate the safety and efficacy of the intravenous infusion of UC-MSC in patients with chronic stable heart failure and reduced ejection fraction. Patients with heart failure and reduced ejection fraction under optimal medical treatment were randomized to intravenous infusion of allogenic UC-MSCs (Cellistem, Cells for Cells S.A., Santiago, Chile; 1×10 6 cells/kg) or placebo (n=15 per group). UC-MSCs in vitro, compared with bone marrow-derived mesenchymal stem cells, displayed a 55-fold increase in the expression of hepatocyte growth factor, known to be involved in myogenesis, cell migration, and immunoregulation. UC-MSC-treated patients presented no adverse events related to the cell infusion, and none of the patients tested at 0, 15, and 90 days presented alloantibodies to the UC-MSCs (n=7). Only the UC-MSC-treated group exhibited significant improvements in left ventricular ejection fraction at 3, 6, and 12 months of follow-up assessed both through transthoracic echocardiography ( P =0.0167 versus baseline) and cardiac MRI ( P =0.025 versus baseline). Echocardiographic left ventricular ejection fraction change from baseline to month 12 differed significantly between groups (+7.07±6.22% versus +1.85±5.60%; P =0.028). In addition, at all follow-up time points, UC-MSC-treated patients displayed improvements of New York Heart Association functional class ( P =0.0167 versus baseline) and Minnesota Living with Heart Failure Questionnaire ( P <0.05 versus baseline). At study completion

In Pursuit of Neurophenotypes: The Consequences of Having Autism and a Big Brain

PubMed Central

Amaral, David G.; Li, Deana; Libero, Lauren; Solomon, Marjorie; Van de Water, Judy; Mastergeorge, Ann; Naigles, Letitia; Rogers, Sally; Nordahl, Christine Wu

2017-01-01

A consensus has emerged that despite common core features, autism spectrum disorder (ASD) has multiple etiologies and various genetic and biological characteristics. The fact that there are likely to be subtypes of ASD has complicated attempts to develop effective therapies. The UC Davis MIND Institute Autism Phenome Project is a longitudinal, multidisciplinary analysis of children with autism and age-matched typically developing controls; nearly 400 families are participating in this study. The overarching goal is to gather sufficient biological, medical, and behavioral data to allow definition of clinically meaningful subtypes of ASD. One reasonable hypothesis is that different subtypes of autism will demonstrate different patterns of altered brain organization or development i.e., different neurophenotypes. In this Commentary, we discuss one neurophenotype that is defined by megalencephaly, or having brain size that is large and disproportionate to body size. We have found that 15% of the boys with autism demonstrate this neurophenotype, though it is far less common in girls. We review behavioral and medical characteristics of the large-brained group of boys with autism in comparison to those with typically sized brains. While brain size in typically developing individuals is positively correlated with cognitive function, the children with autism and larger brains have more severe disabilities and poorer prognosis. This research indicates that phenotyping in autism, like genotyping, requires a very substantial cohort of subjects. Moreover, since brain and behavior relationships may emerge at different times during development, this effort highlights the need for longitudinal analyses to carry out meaningful phenotyping. PMID:28239961

The challenge of compliance and persistence: focus on ulcerative colitis.

PubMed

Kane, Sunanda V; Brixner, Diana; Rubin, David T; Sewitch, Maida J

2008-01-01

Non-adherence to therapy is a widespread problem, with typical adherence rates for prescribed medications being approximately 50%. An estimated 20% to 50% of patients with ulcerative colitis (UC) do not take their medications as prescribed, resulting in higher disease-recurrence rates and potentially higher health care costs. To characterize the problem of non-adherence in UC, to review the many factors affecting compliance and persistence in this population, and to discuss practical strategies to improve adherence in these patients. Adherence to and persistence with medication are complex and multifactorial behaviors. Factors shown to affect adherence in UC patients include disease extent and duration, cost of medications, fear of adverse effects, individual psychosocial variables, and the patient-physician relationship. In contrast, recent data do not support an important role for treatment-related factors such as daily dose, regimen, and formulation in influencing adherence in this population, particularly with longer duration of use. Strategies to improve adherence should involve the patient, the provider, and the health care delivery system. For UC patients, knowledge and discussion of the rationale for supporting persistence, such as recent data regarding agents that have a potential chemoprotective benefit, may encourage persistence, even during periods of quiescence. The patient-physician relationship is critical in encouraging adherence, particularly with respect to education, open communication, and agreement regarding the value of the assigned treatment. Health care delivery systems can improve adherence by encouraging the participation of multidisciplinary teams, providing reporting and tracking systems, and eliminating financial barriers where possible.

A magpie with a card-index mind – Charles Davies Sherborn 1861–1942

PubMed Central

Shindler, Karolyn

2016-01-01

Abstract Charles Davies Sherborn was geologist, indexer and bibliographer extraordinaire. He was fascinated by science from an early age and like so many Victorians, the young Sherborn was a passionate natural history collector and was obsessed with expanding his collection of land and freshwater shells. He later described himself as being a ‘thorough magpie’ and having ‘a card-index mind’, and these two traits coalesced in his monumental Index Animalium, the compilation of which occupied 43 years of his life. One of the first visitors through the doors of the Natural History Museum in South Kensington when it opened in 1881, Sherborn began work there seven years later as one of the small band of unofficial scientific workers, paid by the number of fossils he prepared. By the time of his death in 1942, Sherborn’s corner in the Museum was the first port of call for generations of scientists seeking advice, information – or an invitation to one of his famous ‘smoke and chat’ parties. In addition to his work on the Index, Sherborn is also responsible for rescuing from damp and probable destruction the huge archive of Sir Richard Owen, the great comparative anatomist and the prime mover behind the creation of the Natural History Museum, London. Without Sherborn, this invaluable resource of correspondence, manuscripts and books may well have been irretrievably ruined. PMID:26877651

Coexistence of ulcerative colitis and Sjögren's syndrome in a patient with Takayasu's arteritis and Hashimoto's thyroiditis.

PubMed

Park, Hyun Woo; Lee, Hyun Seok; Hwang, Sejin; Lee, Han Sol; Bae, Han-Ik; Yoon, Ghilsuk

2017-04-01

A 31-year-old woman with a 15-year history of Takayasu's arteritis (TA) and a 13-year history of Hashimoto's thyroiditis presented with hematochezia. She received a diagnosis of Sjögren's syndrome at 1 month before her visit to Kyungpook National University Medical Center. Her colonoscopic findings were compatible with a diagnosis of ulcerative colitis (UC). She was treated with oral mesalazine, and her hematochezia symptoms subsequently disappeared. The coexistence of UC and TA has been reported; however, reports on the coexistence of UC and Sjögren's syndrome, or of UC and Hashimoto's thyroiditis are rare. Although the precise etiologies of these diseases are unknown, their presence together suggests that they may have a common pathophysiologic background. Furthermore, in patients with autoimmune or vascular diseases, including TA, systemic manifestations should be assessed with consideration of inflammatory bowel diseases including UC in the presence of gastrointestinal symptoms such as diarrhea and hematochezia.

Additional evidence of far transfer of scientific reasoning skills acquired in a CLASP reformed physics course

NASA Astrophysics Data System (ADS)

Potter, Wendell H.; Lynch, Robert B.

2013-01-01

The introductory physics course taken by biological science majors at UC Davis, Physics 7, was radically reformed 16 years ago in order to explicitly emphasize the development of scientific reasoning skills in all elements of the course. We have previously seen evidence of increased performance on the biological and physical science portions of the MCAT exam, in a rigorous systemic physiology course, and higher graduating GPAs for students who took Physics 7 rather than a traditionally taught introductory physics course. We report here on the increased performance by a group of biological-science majors in a general chemistry course who took the first quarter of Physics 7 prior to beginning the chemistry course sequence compared to a similar group who began taking physics after completing the first two quarters of general chemistry.

Animal Models: New Biosensors and Technologies?Including Those for Bone Regrowth and Wound Healing?Advance Animal Health Care While Also Providing a Fertile Testing Ground for Human Health.

PubMed

Allen, Summer

2017-01-01

Dogs have bad breath. But when Montana sheep rancher Katy Harjes noticed her collie, Hoshi, had particularly bad breath and facial swelling, she was concerned that the symptoms might be a sign of something serious. She was right; ten-year-old Hoshi had squamous cell carcinoma, a common type of oral tumor found in dogs. The cancer had not metastasized, but the damage was extensive enough that part of Hoshi's lower jaw needed to be removed. Luckily, Hoshi was a suitable candidate for a stateof-the-art bone regrowth procedure developed by Frank Verstraete, B.V.Sc, Dr.Med.Vet., M.Med.Vet., and Boaz Arzi, D.V.M., oral surgeons at the University of California (UC), Davis, School of Veterinary Medicine. Consequently, Katy and Hoshi embarked on a 15-hour road trip to California.

Single event upset sensitivity of low power Schottky devices

NASA Technical Reports Server (NTRS)

Price, W. E.; Nichols, D. K.; Measel, P. R.; Wahlin, K. L.

1982-01-01

Data taken from tests involving heavy ions in the Berkeley 88 in. cyclotron being directed at low power Schottky barrier devices are reported. The tests also included trials in the Harvard cyclotron with 130 MeV protons, and at the U.C. Davis cyclotron using 56 MeV protons. The experiments were performed to study the single event upsets in MSI logic devices containing flip-flops. Results are presented of single-event upsets (SEU) causing functional degradation observed in post-exposure tests of six different devices. The effectiveness of the particles in producing SEUs in logic device functioning was found to be directly proportional to the proton energy. Shielding was determined to offer negligible protection from the particle bombardment. The results are considered significant for the design and fabrication of LS devices for space applications.

An assessment of scientific and technical aspects of closed investigations of canine forensics DNA – case series from the University of California, Davis, USA

PubMed Central

Scharnhorst, Günther; Kanthaswamy, Sree

2011-01-01

Aim To describe and assess the scientific and technical aspects of animal forensic testing at the University of California, Davis. The findings and recommendations contained in this report are designed to assess the past, evaluate the present, and recommend reforms that will assist the animal forensic science community in providing the best possible services that comply with court standards and bear judicial scrutiny. Methods A batch of 32 closed files of domestic dog DNA cases processed at the University of California, Davis, between August 2003 and July 2005 were reviewed in this study. The case files comprised copies of all original paperwork, copies of the cover letter or final report, laboratory notes, notes on analyses, submission forms, internal chains of custody, printed images and photocopies of evidence, as well as the administrative and technical reviews of those cases. Results While the fundamental aspects of animal DNA testing may be reliable and acceptable, the scientific basis for forensic testing animal DNA needs to be improved substantially. In addition to a lack of standardized and validated genetic testing protocols, improvements are needed in a wide range of topics including quality assurance and quality control measures, sample handling, evidence testing, statistical analysis, and reporting. Conclusion This review implies that although a standardized panel of short tandem repeat and mitochondrial DNA markers and publicly accessible genetic databases for canine forensic DNA analysis are already available, the persistent lack of supporting resources, including standardized quality assurance and quality control programs, still plagues the animal forensic community. This report focuses on closed cases from the period 2003-2005, but extends its scope more widely to include other animal DNA forensic testing services. PMID:21674824

Inflammatory bowel disease in Bahrain: single-center experience

PubMed Central

Abdulla, Maheeba; Al Saeed, Mahmood; Fardan, Rawdha Hameed; Alalwan, Hawra Faisal; Ali Almosawi, Zahra S; Almahroos, Amal Fuad; Al Qamish, Jehad

2017-01-01

Purpose The number of newly diagnosed inflammatory bowel disease (IBD) cases such as ulcerative colitis (UC), Crohn’s disease (CD), and indeterminate colitis (IC) is rapidly increasing in Gulf countries and Saudi Arabia. The aim of this study was to investigate the incidence and prevalence of IBD in patients who have attended the Salmaniya Medical Complex, Bahrain, between the years 1984 and 2014. Patients and methods All patients who had attended the Salmaniya Medical Complex, Bahrain, and had been diagnosed with UC, CD, or IC, between the years 1984 and 2014, were included in the analysis. Data collected were: patient demographics, symptoms, clinical signs, complications, surgical interventions, extent of disease, endoscopic findings, histopathology, and lab measurements. Results A total of 187 cases were included; 61 had CD, 123 had UC, and a further 3 cases presented with IC. A clear increase in the incidence and prevalence of IBD can be seen in this cohort. The prevalence of IBD was calculated to be 26.25/105 cases. The average number of IBD cases increased from 3 cases (average for the years 1984–2001) to 12 cases (average for the years 2002–2014). A number of factors correlate positively or negatively with CD and UC. In the current study, a link between gastrointestinal complications in CD cases and the use of steroids as a treatment was noted (p-value −0.02). Age also had a significant influence on the need for surgery in CD cases (p-value −0.04), and a family history of UC was statistically linked to surgical intervention (p-value −0.05). Conclusions IBD can no longer be considered a rare disease in Bahrain. The incidence of both UC and CD is steadily increasing. There is a need for increasing awareness of the Bahraini public to IBD in order for proper medical care to be given. PMID:28765713

Health Care Cost Analysis in a Population-based Inception Cohort of Inflammatory Bowel Disease Patients in the First Year of Diagnosis.

PubMed

Niewiadomski, Olga; Studd, Corrie; Hair, Christopher; Wilson, Jarrad; McNeill, John; Knight, Ross; Prewett, Emily; Dabkowski, Paul; Dowling, Damian; Alexander, Sina; Allen, Benjamin; Tacey, Mark; Connell, William; Desmond, Paul; Bell, Sally

2015-11-01

There are limited prospective population-based data on the health care cost of IBD in the post-biologicals era. A prospective registry that included all incident cases of inflammatory bowel disease [IBD] was established to study disease progress and health cost. To prospectively assess health care costs in the first year of diagnosis among a well-characterised cohort of newly diagnosed IBD patients. Incident cases of IBD were prospectively identified in 2007-2008 and 2010-2013 from multiple health care providers, and enrolled into the population-based registry. Health care resource utilisation for each patient was collected through active surveillance of case notes and investigations including specialist visits, diagnostic tests, medications, medical hospitalisation, and surgery. Off 276 incident cases of IBD, 252 [91%] were recruited to the registry, and health care cost was calculated for 242 (146 Crohn's disease [CD] and 96 ulcerative colitis [UC] patients). The median cost in CD was higher at A$5905 per patient (interquartile range [IQR]: A$1571-$91,324) than in UC at A$4752 [IQR: A$1488-A$58,072]. In CD, outpatient resources made up 55% of all cost, with medications accounting for 32% of total cost [15% aminosalicylates, 15% biological therapy], followed by surgery [31%], and diagnostic testing [21%]. In UC, medications accounted for 39% of total cost [of which 37% was due to 5-aminosalicylates, and diagnostics 29%; outpatient cost contributed 71% to total cost. In the first year of diagnosis, outpatient resources account for the majority of cost in both CD and UC. Medications are the main cost driver in IBD. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Davis Pond freshwater prediversion biomonitoring study: freshwater fisheries and eagles

USGS Publications Warehouse

Jenkins, Jill A.; Bourgeois, E. Beth; Jeske, Clint W.

2008-01-01

In January 2001, the construction of the Davis Pond freshwater diversion structure was completed by the U.S. Army Corps of Engineers. The diversion of freshwater from the Mississippi River is intended to mitigate saltwater intrusion from the Gulf of Mexico and to lessen the concomitant loss of wetland areas. In addition to the freshwater inflow, Barataria Bay basin would receive nutrients, increased flows of sediments, and water-borne and sediment-bound compounds. The purpose of this biomonitoring study was, therefore, to serve as a baseline for prediversion concentrations of selected contaminants in bald eagle (Haliaeetus leucocephalus) nestlings (hereafter referred to as eaglets), representative freshwater fish, and bivalves. Samples were collected from January through June 2001. Two similarly designed postdiversion studies, as described in the biological monitoring program, are planned. Active bald eagle nests targeted for sampling eaglet blood (n = 6) were generally located southwest and south of the diversion structure. The designated sites for aquatic animal sampling were at Lake Salvador, at Lake Cataouatche, at Bayou Couba, and along the Mississippi River. Aquatic animals representative of eagle prey were collected. Fish were from three different trophic levels and have varying feeding strategies and life histories. These included herbivorous striped mullet (Mugil cephalus), omnivorous blue catfish (Ictalurus furcatus), and carnivorous largemouth bass (Micropterus salmoides). Three individuals per species were collected at each of the four sampling sites. Freshwater Atlantic rangia clams (Rangia cuneata) were collected at the downstream marsh sites, and zebra mussels (Dreissena spp.) were collected on the Mississippi River. The U.S. Geological Survey (USGS) Biomonitoring of Environmental Status and Trends (BEST) protocols served as guides for fish sampling and health assessments. Fish are useful for monitoring aquatic ecosystems because they accumulate

Direct evidence of histopathological impacts of wastewater discharge on resident Antarctic fish (Trematomus bernacchii) at Davis Station, East Antarctica.

PubMed

Corbett, Patricia A; King, Catherine K; Stark, Jonathan S; Mondon, Julie A

2014-10-15

During the 2009/2010 summer, a comprehensive environmental impact assessment (EIA) of the wastewater discharge at Davis Station, East Antarctica was completed. As part of this, histological alteration of gill and liver tissue in Antarctic Rock-cod (Trematomus bernacchii) from four sites along a spatial gradient from the wastewater outfall were assessed. All fish within 800 m of the outfall exhibited significant histological changes in both tissues. Common pathologies observed in fish closest to the outfall include proliferation of epithelial cells with associated secondary lamellar fusion in the gills and multifocal granulomata with inflammation and necrosis as well as cysts in the liver. Fish from sites >800 m from the outfall also exhibited alterations but to a lesser degree, with prevalence and severity decreasing with increasing distance from the outfall. This study highlights the value of histopathological investigations as part of EIAs and provides the first evidence of sub-lethal alteration associated with wastewater discharge in East Antarctica. Copyright © 2014 Elsevier Ltd. All rights reserved.

Cost comparison between home telemonitoring and usual care of older adults: a randomized trial (Tele-ERA).

PubMed

Upatising, Benjavan; Wood, Douglas L; Kremers, Walter K; Christ, Sharon L; Yih, Yuehwern; Hanson, Gregory J; Takahashi, Paul Y

2015-01-01

From 1992 to 2008, older adults in the United States incurred more healthcare expense per capita than any other age group. Home telemonitoring has emerged as a potential solution to reduce these costs, but evidence is mixed. The primary aim of the study was to evaluate whether the mean difference in total direct medical cost consequence between older adults receiving additional home telemonitoring care (TELE) (n=102) and those receiving usual medical care (UC) (n=103) were significant. Inpatient, outpatient, emergency department, decedents, survivors, and 30-day readmission costs were evaluated as secondary aim. Multivariate generalized linear models (GLMs) and parametric bootstrapping method were used to model cost and to determine significance of the cost differences. We also compared the differences in arithmetic mean costs. From the conditional GLMs, the estimated mean cost differences (TELE versus UC) for total, inpatient, outpatient, and ED were -$9,537 (p=0.068), -$8,482 (p =0.098), -$1,160 (p=0.177), and $106 (p=0.619), respectively. Mean postenrollment cost was 11% lower than the prior year for TELE versus 22% higher for UC. The ratio of mean cost for decedents to survivors was 2.1:1 (TELE) versus 12.7:1 (UC). There were no significant differences in the mean total cost between the two treatment groups. The TELE group had less variability in cost of care, lower decedents to survivors cost ratio, and lower total 30-day readmission cost than the UC group.

Maintaining remission in ulcerative colitis – role of once daily extended-release mesalamine

PubMed Central

Oliveira, Lilliana; Cohen, Russell D

2011-01-01

The aminosalicylates (5-ASA; also referred to as mesalamine-based agents) are considered as first-line in the maintenance of remission of mild to moderate ulcerative colitis (UC). Traditionally these agents have required a large pill burden and multiple daily dosing regimens which may account for the low adherence rates, especially in patients in remission. Extended-release mesalamine is the first once daily mesalamine product approved by the Food and Drug Administration for the maintenance of UC remission. This review will examine the pharmacokinetics, dosing, efficacy, and safety data of extended-release mesalamine, and discuss the potential role of improving medication compliance and decreasing costs in UC maintenance. PMID:21448448

Maintaining remission in ulcerative colitis--role of once daily extended-release mesalamine.

PubMed

Oliveira, Lilliana; Cohen, Russell D

2011-02-27

The aminosalicylates (5-ASA; also referred to as mesalamine-based agents) are considered as first-line in the maintenance of remission of mild to moderate ulcerative colitis (UC). Traditionally these agents have required a large pill burden and multiple daily dosing regimens which may account for the low adherence rates, especially in patients in remission. Extended-release mesalamine is the first once daily mesalamine product approved by the Food and Drug Administration for the maintenance of UC remission. This review will examine the pharmacokinetics, dosing, efficacy, and safety data of extended-release mesalamine, and discuss the potential role of improving medication compliance and decreasing costs in UC maintenance.

Healthcare Utilisation and Drug Treatment in a Large Cohort of Patients with Inflammatory Bowel Disease

PubMed Central

Wettermark, Björn; Löfberg, Robert; Eriksson, Irene; Sundström, Johan; Lördal, Mikael

2016-01-01

Background and Aims: Crohn’s disease [CD] and ulcerative colitis [UC] are chronic diseases associated with a substantial utilisation of healthcare resources. We aimed to estimate the prevalence of inflammatory bowel disease [IBD], CD, and UC and to describe and compare healthcare utilisation and drug treatment in CD and UC patients. Methods: This was a cross-sectional study of all patients with a recorded IBD diagnosis in Stockholm County, Sweden. Data on outpatient visits, hospitalisations, surgeries, and drug treatment during 2013 were analysed. Results: A total of 13 916 patients with IBD were identified, corresponding to an overall IBD prevalence of 0.65% [CD 0.27%, UC 0.35%, inflammatory bowel disease unclassified 0.04%]; 49% of all IBD patients were treated with IBD-related drugs. Only 3.6% of the patients received high-dose corticosteroids, whereas 32.4% were treated with aminosalicylates [CD 21.2%, UC 41.0%, p < 0.0001]. More CD patients were treated with biologicals compared with UC patients [CD 9.6%, UC 2.9%, p < 0.0001] and surgery was significantly more common among CD patients [CD 3.0%, UC 0.8%, p < 0.0001]. Conclusions: This study indicates that patients with CD are the group with the highest medical needs. Patients with CD utilised significantly more healthcare resources [including outpatient visits, hospitalisations, and surgeries] than UC patients. Twice as many CD patients received immunomodulators compared with UC patients and CD patients were treated with biologicals three times more often. These results highlight that CD remains a challenge and further efforts are needed to improve care in these patients. PMID:26733406

Individual health discount rate in patients with ulcerative colitis.

PubMed

Waljee, Akbar K; Morris, Arden M; Waljee, Jennifer F; Higgins, Peter D R

2011-06-01

In cost-effectiveness analysis, discount rates are used in calculating the value of future costs and benefits. However, standard discount rates may not accurately describe the decision-making of patients with ulcerative colitis (UC). These patients often choose the long-term risks of immunosuppressive therapy over the short-term risks of colectomy, demonstrating very high discount rates for future health. In this study we aimed to measure the discount rate in UC patients and identify variables associated with the discount rate. We surveyed patients with UC and patients who were postcolectomy for UC to measure their valuations of UC and colectomy health states. We used Standard Gamble (SG) and Time-Trade-Off (TTO) methods to assess current and future health state valuations and calculated the discount rate. Participants included 150 subjects with UC and 150 subjects who were postcolectomy for UC. Adjusted discount rates varied widely (0%-100%), with an overall median rate of 55.0% (interquartile range [IQR] 20.6-100), which was significantly higher than the standard rate of 5%. Within the normal range of discount rates, patients' expected discount rate increased by 0.80% for each additional year of age, and female patients had discount rates that averaged ≈ 8% less than their age-matched counterparts and approached statistical significance. The accepted discount rate of 5% grossly underestimates UC patients' preference for long-term over short-term risk. This might explain UC patients' frequent choice of the long-term risks of immunosuppressive medical therapy over the short-term risks of colectomy. Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.

Validation of the "German Inflammatory Bowel Disease Activity Index (GIBDI)": An Instrument for Patient-Based Disease Activity Assessment in Crohn's Disease and Ulcerative Colitis.

PubMed

Hüppe, Angelika; Langbrandtner, Jana; Häuser, Winfried; Raspe, Heiner; Bokemeyer, Bernd

2018-05-09

 Assessment of disease activity in Crohn's disease (CD) and ulcerative colitis (UC) is usually based on the physician's evaluation of clinical symptoms, endoscopic findings, and biomarker analysis. The German Inflammatory Bowel Disease Activity Index for CD (GIBDI CD ) and UC (GIBDI UC ) uses data from patient-reported questionnaires. It is unclear to what extent the GIBDI agrees with the physicians' documented activity indices.  Data from 2 studies were reanalyzed. In both, gastroenterologists had documented disease activity in UC with the partial Mayo Score (pMS) and in CD with the Harvey Bradshaw Index (HBI). Patient-completed GIBDI questionnaires had also been assessed. The analysis sample consisted of 151 UC and 150 CD patients. Kappa coefficients were determined as agreement measurements.  Rank correlations were 0.56 (pMS, GIBDI UC ) and 0.57 (HBI, GIBDI CD ), with p < 0.001. The absolute agreement for 2 categories of disease activity (remission yes/no) was 74.2 % (UC) and 76.6 % (CD), and for 4 categories (none/mild/moderate/severe) 60.3 % (UC) and 61.9 % (CD). The kappa values ranged between 0.47 for UC (2 categories) and 0.58 for CD (4 categories).  There is satisfactory agreement of GIBDI with the physician-documented disease activity indices. GIBDI can be used in health care research without access to assessments of medical practitioners. In clinical practice, the index offers a supplementary source of information. © Georg Thieme Verlag KG Stuttgart · New York.