PAH 8μm Emission as a Diagnostic of HII Region Optical Depth

NASA Astrophysics Data System (ADS)

Oey, M. S.; Lopez-Hernandez, J.; Kellar, J. A.; Pellegrini, E. W.; Gordon, Karl D.; Jameson, Katherine; Li, Aigen; Madden, Suzanne C.; Meixner, Margaret; Roman-Duval, Julia; Bot, Caroline; Rubio, Monica; Tielens, A. G. G. M.

2017-01-01

PAHs are easily destroyed by Lyman continuum radiation and so in optically thick Stromgren spheres, they tend to be found only on the periphery of HII regions, rather than in the central volume. We therefore expect that in HII regions that are optically thin to ionizing radiation, PAHs would be destroyed beyond the primary nebular structure. Using data from the Spitzer SAGE survey of the Magellanic Clouds, we test whether 8 μm emission can serve as a diagnostic of optical depth in HII regions. We find that 8 μm emission does provide valuable constraints in the Large Magellanic Cloud, where objects identified as optically thick by their atomic ionization structure have 6 times higher median 8 μm surface brightness than optically thin objects. However, in the Small Magellanic Cloud, this differentiation is not observed. This appears to be caused by extremely low PAH production in this low-metallicity environment, such that any differentiation between optically thick and thin objects is washed out by stochastic variations, likely driven by the interplay between dust production and UV destruction. Thus, PAH emission is sensitive to nebular optical depth only at higher metallicities.

MSX Colors of Radio-Selected HII Regions in the Milky Way

NASA Astrophysics Data System (ADS)

Giveon, U.; Becker, R. H.; Helfand, D. J.; White, R. L.

2004-12-01

Investigation of the color properties of sources in the MSX catalog reveals two populations - a blue population composed of mainly evolved stars, masers and molecular clouds, and a red population composed mainly HII regions, planetary nebulae, and unclassified radio sources. We compare the MSX catalog to 5 GHz VLA maps of the first quadrant of the Galactic plane (350oHII regions, most of them unclassified so far.

[NEII] Line Velocity Structure of Ultracompact HII Regions

NASA Astrophysics Data System (ADS)

Okamoto, Yoshiko K.; Kataza, Hirokazu; Yamashita, Takuya; Miyata, Takashi; Sako, Shigeyuki; Honda, Mitsuhiko; Onaka, Takashi; Fujiyoshi, Takuya

Newly formed massive stars are embedded in their natal molecular clouds and are observed as ultracompact HII regions. They emit strong ionic lines such as [NeII] 12.8 micron. Since Ne is ionized by UV photons of E>21.6eV which is higher than the ionization energy of hydrogen atoms the line probes the ionized gas near the ionizing stars. This enables to probe gas motion in the vicinity of recently-formed massive stars. High angular and spectral resolution observations of the [NeII] line will thus provide siginificant information on structures (e.g. disks and outflows) generated through massive star formation. We made [NeII] spectroscopy of ultracompact HII regions using the Cooled Mid-Infrared Camera and Spectrometer (COMICS) on the 8.2m Subaru Telescope in July 2002. Spatial and spectral resolutions were 0.5"" and 10000 respectively. Among the targets G45.12+0.13 shows the largest spatial variation in velocity. The brightest area of G45.12+0.13 has the largest line width in the object. The total velocity deviation amounts to 50km/s (peak to peak value) in the observed area. We report the velocity structure of [NeII] emission of G45.12+0.13 and discuss the gas motion near the ionizing star.

Smoothed particle hydrodynamic simulations of expanding HII regions

NASA Astrophysics Data System (ADS)

Bisbas, Thomas G.

2009-09-01

This thesis deals with numerical simulations of expanding ionized regions, known as HII regions. We implement a new three dimensional algorithm in Smoothed Particle Hydrodynamics for including the dynamical effects of the interaction between ionizing radiation and the interstellar medium. This interaction plays a crucial role in star formation at all epochs. We study the influence of ionizing radiation in spherically symmetric clouds. In particular, we study the spherically symmetric expansion of an HII region inside a uniform-density, non-self-gravitating cloud. We examine the ability of our algorithm to reproduce the known theoretical solution and we find that the agreement is very good. We also study the spherically symmetric expansion inside a uniform-density, self-gravitating cloud. We propose a new differential equation of motion for the expanding shell that includes the effects of gravity. Comparing its numerical solution with the simulations, we find that the equation predicts the position of the shell accurately. We also study the expansion of an off-centre HII region inside a uniform-density, non- self-gravitating cloud. This results in an evolution known as the rocket effect, where the ionizing radiation pushes and accelerates the cloud away from the exciting star leading to its dispersal. During this evolution, cometary knots appear as a result of Rayleigh-Taylor and Vishniac instabilities. The knots are composed of a dense head with a conic tail behind them, a structure that points towards the ionizing source. Our simulations show that these knots are very reminiscent of the observed structures in planetary nebula, such as in the Helix nebula. The last part of this thesis is dedicated to the study of cores ionized by an exciting source which is placed outside and far away from them. The evolution of these cores is known as radiation driven compression (or implosion). We perform simulations and compare our findings with results of other workers and we

Properties of compact HII regions and their host clumps in the inner vs outer Galaxy - early results from SASSy

NASA Astrophysics Data System (ADS)

Djordjevic, Julie; Thompson, Mark; Urquhart, James S.

2017-01-01

We present a catalog of compact and ultracompact HII regions for all Galactocentric radii. Previous catalogs focus on the inner Galaxy (Rgal ≤ 8 kpc) but the recent SASSy 870 µm survey allows us to identify regions out to ~20 kpc. Early samples are also filled with false classifications leading to uncertainty when deriving star formation efficiencies in Galactic models. These objects have similar mid-IR colours to HII regions. Urquhart et al. (2013) found that they could use mid-IR, submm, and radio data to identify the genuine compact HII regions, avoiding confusion. They used this method on a small portion of the Galaxy (10 < l < 60), identifying 213 HII regions embedded in 170 clumps. We use ATLASGAL and SASSy, crossmatched with RMS, to sample the remaining galactic longitudes out to Rgal = 20 kpc. We derive the properties of the identified compact HII regions and their host clumps while addressing the implications for recent massive star formation in the outer Galaxy. Observations towards nearby galaxies are biased towards massive stars, affecting simulations and overestimating models for galactic evolution and star formation rates. The Milky Way provides the ideal template for studying factors affecting massive star formation rates and efficiencies at high resolution, thus fine-tuning those models. We find that there is no significant change in the rate of massive star formation in the outer vs inner Galaxy. Despite some peaks in known complexes and possible correlation with spiral arms, the outer Galaxy appears to produce massive stars as efficiently as the inner regions. However, many of the potential star forming SASSy clumps have no available radio counterpart to confirm the presence of an HII region or other star formation tracer. Follow-up observations will be required to verify this conclusion and are currently in progress.

Identification and multi-filter photometry of HII regions from nearby galaxies with J-PLUS

NASA Astrophysics Data System (ADS)

Logroño-García, R.; Vilella-Rojo, G.; López-Sanjuan, C.; Varela, J.; Muniesa, D.; Lamadrid, J. L.; Cenarro, A. J.; J-PLUS, T.

2017-03-01

The Javalambre Photometric Local Universe Survey (J-PLUS) has already started the data acquisition phase at the Observatorio Astrofísico de Javalambre (OAJ) in Teruel, Spain. Benefiting from the large field of view (2 deg^2) and the 12 filters set of the T80Cam at the T80/JAST telescope, we aim to study the properties of HII regions in nearby galaxies (z < 0.015). In this poster, we apply our procedures to the galaxy Messier 101. We have developed a fully automatized pipeline to identify and characterize the nearby universe HII regions. This pipeline: (1) Homogenizes the PSF in the 12 images of the different filters. (2) Estimates realistic photometric errors following Labbé et al. (2003) method. (3) Constructs a detection image showing the excess of Hα+[NII], following Vilella-Rojo et al. (2015) prescriptions. (4) Performs the photometry in the 12 J-PLUS bands using as reference the Hα+NII detection image. (5) Constructs the photo-spectra for each identified HII region. We demonstrate the capabilities of this method by comparing synthetic aperture photometry from SDSS spectra with the Hα flux measured with J-PLUS data. Such comparison can be found in the poster by Vilella-Rojo et al. Once the pipeline is implemented, we will generate a catalog of nearby HII regions at z<0.015 in the 8500deg^2 of J-PLUS. With this catalog, we will study the impact of environment in the 2D star formation properties of nearby galaxies, taking advantage of the unprecedented large contiguous area that J-PLUS will offer.

Examining Sites of Recent Star Formation in the Galactic Center: A Closer Look at the Arched Filaments and H HII Regions

NASA Astrophysics Data System (ADS)

Hankins, Matthew; Herter, Terry; Lau, Ryan; Morris, Mark; Mills, Elisabeth

2018-01-01

In this dissertation presentation, we analyze mid-infrared imaging of the Arched Filaments and H HII regions in the Galactic center taken with the Faint Object Infrared Camera for the SOFIA Telescope (FORCAST). Examining these regions are of great interest because they provide insights on star formation in the Galactic center and the interactions massive stars have with the ISM. The Arched Filaments are a collection of molecular cloud ridges which are ionized by the nearby Arches star cluster, and give the appearance of large (~25 pc) arch-like structures. The H HII regions are a collection of HII regions just to the west of the Arches cluster (~5-15 pc). The origin of the stars powering the H HII regions is uncertain, as they may have formed in a nearby molecular cloud or could be ejected members of the Arches cluster. FORCAST observations of these regions were used to study the morphology and heating structure of the HII regions, as well as constrain their luminosities.Color-temperature maps of the Arched Filaments created with the FORCAST data reveals fairly uniform dust temperatures (~70-100 K) across the length filaments. The temperature uniformity of the clouds can be explained if they are heated by the Arches cluster but are located at a larger distance from the cluster than they appear. The density of the Arched Filaments clouds was estimated from the FORCAST data and was found to be below the threshold for tidal shearing, indicating that that the clouds will be destroyed by the strong tidal field near the Galactic center. To the west of the Arched Filaments, there is an interesting collection of HII regions, referred to as the H HII regions. These regions are likely heated by massive O/B type stars, and the morphology of the dust emission associated with these objects indicate a mixture of potential in situ formation mechanisms and interlopers. Interestingly, FORCAST imaging of the H HII regions also reveal several compact sources, which may be young

Non-equilibrium electron energy distributions in HII regions: Implications for abundance determinations

NASA Astrophysics Data System (ADS)

Dopita, Michael; Nicholls, David

2012-07-01

Although the analysis of HII region emission lines provides the main way of probing the chemical evolution of the universe throughout cosmic time, currently significant (factor of 2) discrepancies exist between the different methods (principally the strong line, electron temperature and recombination line methods) used to calibrate the cosmic chemical abundance scale. Although effects such as temperature fluctuations and geometrical effects have been invoked, these fail to explain the observations, particularly in the UV. Here we will show that there exists good grounds for supposing that the electrons in HII regions, as in other space plasmas, are not distributed according to a Boltzmann law. Rather, they follow a κ- distribution with κ ˜ 10. With this novel formulation, we can resolve the abundance discrepancies which have plagued this field for over three decades. Interestingly enough, the size of the correction in emission line strengths increases as we go into the UV.

Formation of structures around HII regions: ionization feedback from massive stars

NASA Astrophysics Data System (ADS)

Tremblin, P.; Audit, E.; Minier, V.; Schmidt, W.; Schneider, N.

2015-03-01

We present a new model for the formation of dense clumps and pillars around HII regions based on shocks curvature at the interface between a HII region and a molecular cloud. UV radiation leads to the formation of an ionization front and of a shock ahead. The gas is compressed between them forming a dense shell at the interface. This shell may be curved due to initial interface or density modulation caused by the turbulence of the molecular cloud. Low curvature leads to instabilities in the shell that form dense clumps while sufficiently curved shells collapse on itself to form pillars. When turbulence is high compared to the ionized-gas pressure, bubbles of cold gas have sufficient kinetic energy to penetrate into the HII region and detach themselves from the parent cloud, forming cometary globules. Using computational simulations, we show that these new models are extremely efficient to form dense clumps and stable and growing elongated structures, pillars, in which star formation might occur (see Tremblin et al. 2012a). The inclusion of turbulence in the model shows its importance in the formation of cometary globules (see Tremblin et al. 2012b). Globally, the density enhancement in the simulations is of one or two orders of magnitude higher than the density enhancement of the classical ``collect and collapse`` scenario. The code used for the simulation is the HERACLES code, that comprises hydrodynamics with various equation of state, radiative transfer, gravity, cooling and heating. Our recent observations with Herschel (see Schneider et al. 2012a) and SOFIA (see Schneider et al. 2012b) and additional Spitzer data archives revealed many more of these structures in regions where OB stars have already formed such as the Rosette Nebula, Cygnus X, M16 and Vela, suggesting that the UV radiation from massive stars plays an important role in their formation. We present a first comparison between the simulations described above and recent observations of these regions.

MSX Colors of Radio-Selected HII Regions in the Milky Way

NASA Astrophysics Data System (ADS)

Giveon, U.; Becker, R. H.; Helfand, D. J.; White, R. L.

2003-12-01

Investigation of the color-space properties of mid-infrared sources in the MSX Galactic plane catalog reveals two distinct populations - a blue population composed mainly of evolved stars, masers and molecular clouds, and a red population comprising sources of a nebular nature - HII regions, planetary nebulae, and unclassified radio sources. We compare the MSX catalog to 5 GHz VLA maps of the first quadrant of the Galactic plane. A catalog extracted from these maps was published first by Becker et al., but we have re-reduced the data with significantly improved calibration and mosaicing procedures, resulting in an increase of ˜ 60% in the number of detected sources. Comparison of the radio and infrared catalogs resulted in a sample of 491 matches, out of which we estimate 38 to be false counterparts, all of them from the MSX red population. The radio sources with infrared counterparts are found to have extremely small scale height (FWHM of 14' or ˜ 35 pc), and have thermal radio spectrum. These properties suggest that the sample is dominated by HII regions, most of them are previously uncataloged. This research is supported be the National Science Foundation.

Internal variation of electron temperature in HII regions

NASA Astrophysics Data System (ADS)

Oliveira, V. A.

2017-11-01

It is usual to think that if you calculate the same physical propriety from different methods you must find the same result, or within the margin of error. However, this is not the case if you calculate the abundance of heavy elements in photoionized nebulae. In fact, it is possible to find a value at least two times bigger, according to whether you estimate from recombination lines or from collisionally excited emission lines. This is called AD problem, and since 1967 the astronomers think about it and we do not have any final conclusion yet. This work aims to bring a small light to the path of a solution of AD problem, specifically for HII regions and, perhaps, to all types of photoionized nebulae.

Exploring the 13CO/C18O abundance ratio towards Galactic young stellar objects and HII regions

NASA Astrophysics Data System (ADS)

Areal, M. B.; Paron, S.; Celis Peña, M.; Ortega, M. E.

2018-05-01

Aims: Determining molecular abundance ratios is important not only for the study of Galactic chemistry, but also because they are useful to estimate physical parameters in a large variety of interstellar medium environments. One of the most important molecules for tracing the molecular gas in the interstellar medium is CO, and the 13CO/C18O abundance ratio is usually used to estimate molecular masses and densities of regions with moderate to high densities. Nowadays isotope ratios are in general indirectly derived from elemental abundances ratios. We present the first 13CO/C18O abundance ratio study performed from CO isotope observations towards a large sample of Galactic sources of different natures at different locations. Methods: To study the 13CO/C18O abundance ratio, we used 12CO J = 3 - 2 data obtained from the CO High-Resolution Survey, 13CO and C18O J = 3 - 2 data from the 13CO/C18O (J = 3 - 2) Heterodyne Inner Milky Way Plane Survey, and some complementary data extracted from the James Clerk Maxwell Telescope database. We analyzed a sample of 198 sources composed of young stellar objects (YSOs), and HII and diffuse HII regions as catalogued in the Red MSX Source Survey in 27.°5 ≤ l ≤ 46.°5 and |b|0.°5. Results: Most of the analyzed sources are located in the galactocentric distance range 4.0-6.5 kpc. We found that YSOs have, on average, lower 13CO/C18O abundance ratios than HII and diffuse HII regions. Taking into account that the gas associated with YSOs should be less affected by the radiation than in the case of the others sources, selective far-UV photodissociation of C18O is confirmed. The 13CO/C18O abundance ratios obtained in this work are systematically lower than those predicted from the known elemental abundance relations. These results will be useful in future studies of molecular gas related to YSOs and HII regions based on the observation of these isotopes.

H-alpha observations of Sh2-190, Sh2-222, Sh2-229, Sh2-236 HII regions

NASA Astrophysics Data System (ADS)

Sahan, Muhittin

2018-02-01

Hα spectral line (6563Å) profiles of four northern HII regions in the our galaxy (Sh2-190, Sh2-222, Sh2-229, Sh2-236) have been obtained using DEFPOS spectrometer, located at coude focus of 150 cm RTT150 telescope at TUBITAK National Observatory (TUG, Antalya, Turkey). Observations were carried out at nights of 2015 December 24-27 with long exposure times ranging from 900s to 3600s. The LSR velocities and the linewidths (Full Width Half Maximum: FWHM) of the Hα emission lines were found to be in the range of -45.46 kms-1 to +3.57 kms-1 and 38.50 kms-1 to 44.10 kms-1, respectively. The Sh2-229 HII region is the faintest one (211.16 R), while the Sh2-236 HII region (IC410) is brightest source (535.75 R). The LSR velocity and the line width (FWHM) results of the DEFPOS/RTT150 system were compared with the data by several authors given in literature and results of DEFPOS data were found to be in good agreement with data given in literature.

IRAS 01202+6133 : A Possible Case of Protostellar Collapse Triggered by a Small HII Region

NASA Astrophysics Data System (ADS)

Kang, Sung-Ju; Kerton, C.

2012-01-01

The molecular gas surrounding an HII region is thought to be a place where star formation can be induced. One of the main questions in the study of star formation is how protostars accrete material from their parent molecular clouds and observations of infall motions are needed to provide direct evidence for accretion. This poster will present an analysis of submm spectroscopic observations of the submm/infrared source IRAS 01202+6133 located on the periphery of the HII region KR 120. HCO+(J=3-2) spectra of this source show a classic blue-dominated double-peaked profile indicative of infall motions that would be expected to occur in the envelope surrounding a young protostellar object. The HCO+ spectrum toward the core was fitted using models incorporating both outflow and infall components along with basic assumptions regarding excitation temperature trends within molecular cloud cores. Using the models, we derive physical properties of the infall kinematics and the envelope structure.

Deep echelle spectrophotometry of S 311, a Galactic HII region located outside the solar circle

NASA Astrophysics Data System (ADS)

García-Rojas, J.; Esteban, C.; Peimbert, A.; Peimbert, M.; Rodríguez, M.; Ruiz, M. T.

2005-09-01

We present echelle spectrophotometry of the Galactic HII region S 311. The data have been taken with the Very Large Telescope Ultraviolet-Visual Echelle Spectrograph in the 3100-10400 Årange. We have measured the intensities of 263 emission lines; 178 are permitted lines of H0, D0 (deuterium), He0, C0, C+, N0, N+, O0, O+, S+, Si0, Si+, Ar0 and Fe0; some of them are produced by recombination and others mainly by fluorescence. Physical conditions have been derived using different continuum- and line-intensity ratios. We have derived He+, C++ and O++ ionic abundances from pure recombination lines as well as abundances from collisionally excited lines for a large number of ions of different elements. We have obtained consistent estimations of t2 applying different methods. We have found that the temperature fluctuations paradigm is consistent with the Te(HeI) versus Te(HI) relation for HII regions, in contrast with what has been found for planetary nebulae. We report the detection of deuterium Balmer lines up to Dδ in the blue wings of the hydrogen lines, whose excitation mechanism seems to be continuum fluorescence.

The critical density for star formation in HII galaxies

NASA Technical Reports Server (NTRS)

Taylor, Christopher L.; Brinks, Elias; Skillman, Evan D.

1993-01-01

The star formation rate (SFR) in galaxies is believed to obey a power law relation with local gas density, first proposed by Schmidt (1959). Kennicutt (1989) has shown that there is a threshold density above which star formation occurs, and for densities at or near the threshold density, the DFR is highly non-linear, leading to bursts of star formation. Skillman (1987) empirically determined this threshold for dwarf galaxies to be approximately 1 x 10(exp 21) cm(exp -2), at a linear resolution of 500pc. During the course of our survey for HI companion clouds to HII galaxies, we obtained high resolution HI observations of five nearby HII galaxies. HII galaxies are low surface brightness, rich in HI, and contain one or a few high surface brightness knots whose optical spectra resemble those of HII regions. These knots are currently experiencing a burst of star formation. After Kennicutt (1989) we determine the critical density for star formation in the galaxies, and compare the predictions with radio and optical data.

El medio interestelar en los alrededores de la region HII Sh2-183

NASA Astrophysics Data System (ADS)

Cichowolski, S.; Cappa, C. E.; Blanco, A.; Eppens, L.; Ertini, K.; Leiva, M. M.

2017-10-01

We present a multiwavelength study of the HII region Sh2-183, located at (,) = (123.3,+3.0) at a distance of 7.0 1.5 kpc from the Sun. Based on the radio continuum data we estimated the amount of ionized gas, the electronic density, and the number of ionizing photons needed to keep the region ionized, which is important since the star/s responsible of the region was/were not detected yet. On the other hand, based on IRAS data we have analyzed the dust temperature and distribution. The Hi line data allowed the detection of a shell-like structure surrounding the ionized gas and the CO data revealed the presence of 6 molecular clouds probably related to Sh2-183, which harbor several young stellar object candidates.

Multi-Wavelength Study of W40 HII Region

NASA Astrophysics Data System (ADS)

Shenoy, Sachindev S.; Shuping, R.; Vacca, W. D.

2013-01-01

W40 is an HII region (Sh2-64) within the Serpens molecular cloud in the Aquila rift region. Recent near infrared spectroscopic observations of the brightest members of the central cluster of W40 reveal that the region is powered by at least three early B-type stars and one late O-type star. Near and mid-infrared spectroscopy and photometry, combined with SED modeling of these sources, suggest that the distance to the cluster is between 455 and 535 pc, with about 10 mag of visual extinction. Velocity and extinction measurement of all the nearby regions i.e. Serpens main, Aquila rift, and MWC297 suggest that the entire system (including the W40 extended emission) is associated with the extinction wall at 260 pc. Here we present some preliminary results of a multi-wavelength study of the central cluster and the extended emission of W40. We used Spitzer IRAC data to measure accurate photometry of all the point sources within 4.32 pc of W40 via PRF fitting. This will provide us with a complete census of YSOs in the W40 region. The Spitzer data are combined with publicly available data in 2MASS, WISE and Hershel archives and used to model YSOs in the region. The SEDs and near-IR colors of all the point sources should allow us to determine the age of the central cluster of W40. The results from this work will put W40 in a proper stellar evolutionary context. After subtracting the point sources from the IRAC images, we are able to study the extended emission free from point source contamination. We choose a few morphologically interesting regions in W40 and use the data to model the dust emission. The results from this effort will allow us to study the correlation between dust properties and the large scale physical properties of W40.

Radiation-MHD Simulations of Pillars and Globules in HII Regions

NASA Astrophysics Data System (ADS)

Mackey, J.

2012-07-01

Implicit and explicit raytracing-photoionisation algorithms have been implemented in the author's radiation-magnetohydrodynamics code. The algorithms are described briefly and their efficiency and parallel scaling are investigated. The implicit algorithm is more efficient for calculations where ionisation fronts have very supersonic velocities, and the explicit algorithm is favoured in the opposite limit because of its better parallel scaling. The implicit method is used to investigate the effects of initially uniform magnetic fields on the formation and evolution of dense pillars and cometary globules at the boundaries of HII regions. It is shown that for weak and medium field strengths an initially perpendicular field is swept into alignment with the pillar during its dynamical evolution, matching magnetic field observations of the ‘Pillars of Creation’ in M16. A strong perpendicular magnetic field remains in its initial configuration and also confines the photoevaporation flow into a bar-shaped, dense, ionised ribbon which partially shields the ionisation front.

VizieR Online Data Catalog: Multiwavelength study of HII region S311 (Yadav+, 2016)

NASA Astrophysics Data System (ADS)

Yadav, R. K.; Pandey, A. K.; Sharma, S.; Ojha, D. K.; Samal, M. R.; Mallick, K. K.; Jose, J.; Ogura, K.; Richichi, A.; Irawati, P.; Kobayashi, N.; Eswaraiah, C.

2017-11-01

We observed the HII region S311 (centred on RA(2000)=07:52:24, DE(2000)=-26:24:58.40) in NIR broad-bands J (1.25um), H (1.63um) and Ks (2.14um) on 2010 March 3 using the Infrared Side Port Imager (ISPI) camera mounted on the CTIO Blanco 4-m telescope. We consider only those sources having error <0.1mag in all three bands, resulting in a final catalogue of 2671 point sources. The Spitzer-IRAC observations for the S311 region (PID 20726) were made on 2006 May 3 using the 3.6, 4.5, 5.8 and 8.0um bands and were downloaded from the Spitzer heritage archive (SHA). (4 data files).

Analysis Of Ultra Compact Ionized Hydrogen Regions Within The Northern Half Of The Galactic Disk

NASA Astrophysics Data System (ADS)

Bruce, John

2011-01-01

From a catalog of 199 candidate ultra compact (UC) HII regions 123 sources included in the the intersection of the GLIMPSE (8 μm),Cornish (6 cm), and Bolocam ( 1.1 mm) galactic plane surveys (BGPS) were analyzed. The sources were sorted based on 6 cm morphology and coincidence with 8 μm bubbles. The 1.1 mm flux attributes were measured and calculations were performed to determine the ionized hydrogen contributions to the 1.1 mm flux. The category averages and frequencies were obtained as well. Significant differences in HII percentages were present among the morphology groups but ranged widely, without apparent distinction, between the bubble forming and triggered source categories.

Circumstantial Starbirth in Starbursts: Systematic Variations in the Stellar and Nebular Content of Giant HII Regions in the Local Group Galaxy M33

NASA Astrophysics Data System (ADS)

Waller, W. H.; Murphy, E. J.; Gherz, R. D.; Polomski, E.; Woodward, C. E.; Fazio, G. G.; Rieke, G. H.; Spitzer/M33 Research Team

2005-12-01

From the Orion Nebula to the Hubble Deep Field, starburst activity can be seen transforming galaxian clouds of gas into populous clusters of stars. The pyrotechnics and chemical enrichment associated with this activity have led to outcomes as ubiquitous as interstellar dust and as exquisite as life on Earth. In this talk, I will focus on the circumstances of star formation in the environmental context of ongoing starburst activity. I begin with the premises that (1) the formation of a single star takes time, (2) the formation of a populous cluster takes even more time, and (3) ''stuff'' happens in the interim. Hubble images of the Orion Nebula and Eagle Nebula show how hot stars can excavate neighboring clouds of gas and photoevaporate the star-forming cores that are exposed. Hubble observations of giant HII regions in M33 reveal a significant variation in the stellar populations, such that the most metal-rich HII regions contain the greatest proportions of the most massive stars. ISO and Spitzer observations of these same HII regions reveal corresponding variations in the nebular content. These multi-wavelength diagnostics of the stellar-nebular feedback in galaxian starbursts suggest a star-forming mechanism which is subject to photo-evaporative ablation -- an erosive process that is systematically mediated by the metal abundance and corresponding amounts of protective dust in the starbursting environment.

The first CO+ image: I. Probing the HI/H2 layer around the ultracompact HII region Mon R2

PubMed Central

Treviño-Morales, S. P.; Fuente, A.; Sánchez-Monge, Á.; Pilleri, P.; Goicoechea, J. R.; Ossenkopf-Okada, V.; Roueff, E.; Rizzo, J. R.; Gerin, M.; Berné, O.; Cernicharo, J.; Gónzalez-García, M.; Kramer, C.; García-Burillo, S.; Pety, J.

2016-01-01

The CO+ reactive ion is thought to be a tracer of the boundary between a HII region and the hot molecular gas. In this study, we present the spatial distribution of the CO+ rotational emission toward the Mon R2 star-forming region. The CO+ emission presents a clumpy ring-like morphology, arising from a narrow dense layer around the HII region. We compare the CO+ distribution with other species present in photon-dominated regions (PDR), such as [CII] 158 µm, H2 S(3) rotational line at 9.3 µm, polycyclic aromatic hydrocarbons (PAHs) and HCO+. We find that the CO+ emission is spatially coincident with the PAHs and [CII] emission. This confirms that the CO+ emission arises from a narrow dense layer of the HI/H2 interface. We have determined the CO+ fractional abundance, relative to C+ toward three positions. The abundances range from 0.1 to 1.9 ×10−10 and are in good agreement with previous chemical model, which predicts that the production of CO+ in PDRs only occurs in dense regions with high UV fields. The CO+ linewidth is larger than those found in molecular gas tracers, and their central velocity are blue-shifted with respect to the molecular gas velocity. We interpret this as a hint that the CO+ is probing photo-evaporating clump surfaces. PMID:27721515

Genetic characterization of UCS region of Pneumocystis jirovecii and construction of allelic profiles of Indian isolates based on sequence typing at three regions.

PubMed

Gupta, Rashmi; Mirdha, Bijay Ranjan; Guleria, Randeep; Kumar, Lalit; Luthra, Kalpana; Agarwal, Sanjay Kumar; Sreenivas, Vishnubhatla

2013-01-01

Pneumocystis jirovecii is an opportunistic pathogen that causes severe pneumonia in immunocompromised patients. To study the genetic diversity of P. jirovecii in India the upstream conserved sequence (UCS) region of Pneumocystis genome was amplified, sequenced and genotyped from a set of respiratory specimens obtained from 50 patients with a positive result for nested mitochondrial large subunit ribosomal RNA (mtLSU rRNA) PCR during the years 2005-2008. Of these 50 cases, 45 showed a positive PCR for UCS region. Variations in the tandem repeats in UCS region were characterized by sequencing all the positive cases. Of the 45 cases, one case showed five repeats, 11 cases showed four repeats, 29 cases showed three repeats and four cases showed two repeats. By running amplified DNA from all these cases on a high-resolution gel, mixed infection was observed in 12 cases (26.7%, 12/45). Forty three of 45 cases included in this study had previously been typed at mtLSU rRNA and internal transcribed spacer (ITS) region by our group. In the present study, the genotypes at those two regions were combined with UCS repeat patterns to construct allelic profiles of 43 cases. A total of 36 allelic profiles were observed in 43 isolates indicating high genetic variability. A statistically significant association was observed between mtLSU rRNA genotype 1, ITS type Ea and UCS repeat pattern 4. Copyright © 2012 Elsevier B.V. All rights reserved.

Progress report on the Heavy Ions in Space (HIIS) experiment

NASA Technical Reports Server (NTRS)

Adams, James H., Jr.; Beahm, Lorraine P.; Boberg, Paul R.; Tylka, Allan J.

1993-01-01

One of the objectives of the Heavy Ions In Space (HIIS) experiment is to investigate heavy ions which appear at Long Duration Exposure Facility (LDEF) below the geomagnetic cutoff for fully-ionized galactic cosmic rays. Possible sources of such 'below-cutoff' particles are partially-ionized solar energetic particles, the anomalous component of cosmic rays, and magnetospherically-trapped particles. In recent years, there have also been reports of below-cutoff ions which do not appear to be from any known source. Although most of these observations are based on only a handful of ions, they have led to speculation about 'partially-ionized galactic cosmic rays' and 'near-by cosmic ray sources'. The collecting power of HIIS is order of magnitude larger than that of the instruments which reported these results, so HIIS should be able to confirm these observations and perhaps discover the source of these particles. Preliminary results on below-cutoff heavy-ions are reported. Observations to possible known sources of such ions are compared. A second objective of the HIIS experiment is to measure the elemental composition of ultraheavy galactic cosmic rays, beginning in the tin-barium region of the periodic table. A report on the status of this analysis is presented.

Surface Photometric Properties of HII Galaxies

NASA Astrophysics Data System (ADS)

Vajgel, B.; Telles, E.

2009-05-01

HII galaxies are dwarf galaxies undergoing violent star formation. They were firstly selected by objective-prism spectroscopy and were object of extensive studies to characterize their physical conditions of the interstellar medium. Their SFR together with their low Z raised the question whether some of them can be truly ``young'' galaxies. To infer the SFH, one needs information in a large spectral range. We obtained images in the optical region of the spectrum with the 0.6 m B&C and the 1.6 m telescopes at the Laboratório Nacional de Astrofísica, for a sample of 50 objects in B, V, R and I, which combined with recent evolutionary models, enable us to deduce the stellar population content and its spatial distribution. These seem to be the nearest youngest galaxies that can be studied in detail, and their structural properties offer important indications about the evolutionary relation and the origin of dwarf galaxies in the universe. With this sample we built a morphological catalogue with broad-band photometry, including the structural analysis through the brightness profiles. The initial analysis suggests that the galaxies can be segregated in two broad classes, in agreement with what had already been proposed in the literature; Type I have irregular envelopes with signs of perturbation and turn out to the more luminous sub-sample; while Type II have regular external isophotes and are less luminous. The brightness profiles are well represented by exponential fits, as in irregular and elliptical dwarf galaxies. However, HII galaxies are more compact in comparison with their more diffuse counterparts. We study the behavior of the HII galaxies in the metallicity-luminosity plane. This relation, interpreted as a relation between the mass and the metallicity of dwarf galaxies of low surface brightness (dE and dIrr), has direct implications for their formation and evolution, and over the possible evolutionary links between HII galaxies and other types of dwarf

Dynamical models for the formation of elephant trunks in HII regions

NASA Astrophysics Data System (ADS)

Mackey, Jonathan; Lim, Andrew J.

2010-04-01

The formation of pillars of dense gas at the boundaries of HII regions is investigated with hydrodynamical numerical simulations including ionizing radiation from a point source. We show that shadowing of ionizing radiation by an inhomogeneous density field is capable of forming so-called elephant trunks (pillars of dense gas as in e.g. M16) without the assistance of self-gravity or of ionization front and cooling instabilities. A large simulation of a density field containing randomly generated clumps of gas is shown to naturally generate elephant trunks with certain clump configurations. These configurations are simulated in isolation and analysed in detail to show the formation mechanism and determine possible observational signatures. Pillars formed by the shadowing mechanism are shown to have rather different velocity profiles depending on the initial gas configuration, but asymmetries mean that the profiles also vary significantly with perspective, limiting their ability to discriminate between formation scenarios. Neutral and molecular gas cooling are shown to have a strong effect on these results.

On the status report of the H-II launch vehicle

NASA Astrophysics Data System (ADS)

Eto, Takao; Shibato, Yoji; Takatsuka, H.; Fukushima, Y.

1988-10-01

This paper describes the present status of the design and the development of the H-II launch vehicle which is being presently developed by NASDA to meet the demand for larger satellite launches at a lower cost. The H-II systems, including its solid rocket boosters and the guidance and control system, are discussed together with the launch facilities and launch operation. The paper includes diagrams of the H-II systems and a table listing H-II characteristics.

Radiation-MHD models of elephant trunks and globules in HII regions

NASA Astrophysics Data System (ADS)

Mackey, Jonathan; Lim, Andrew J.

2011-01-01

We study the formation and evolution of pillars of dense gas, known as elephant trunks, at the boundaries of HII regions, formed by shadowing of ionising radiation by dense clumps. The effects of magnetic fields on this process are investigated using 3D radiation-magnetohydrodynamics simulations. For a simulation in which an initially uniform magnetic field of strength \\vert B\\vert≃50 μG is oriented perpendicular to the radiation propagation direction, the field is swept into alignment with the pillar during its dynamical evolution, in agreement with observations of the ``Pillars of Creation'' in M16, and of some cometary globules. This effect is significantly enhanced when the simulation is re-run with a weaker field of ≃18 μG. A stronger field with \\vert B\\vert≃ 160 μG is sufficient to prevent this evolution completely, also significantly affecting the photoionisation process. Using a larger simulation domain it is seen that the pillar formation models studied in Mackey & Lim (2010) ultimately evolve to cometary structures in the absence of dense gas further from the star.

ISO Mid-Infrared Observations of Giant HII Regions in M33

NASA Technical Reports Server (NTRS)

Skelton, B. P.; Waller, W. H.; Hodge, P. W.; Boulanger, F.; Cornett, R. H.; Fanelli, M. N.; Lequeux, J.; Stecher, T. P.; Viallefond, F.; Hui, Y.

1999-01-01

We present Infrared Space Observatory Camera (ISOCAM) Circular Variable Filter scans of three giant HII regions in M33. IC 133, NGC 595, and CC 93 span a wide range of metallicity, luminosity, nebular excitation, and infrared excess; three other emission regions (CC 43, CC 99, and a region to the northeast of the core of NGC 595) are luminous enough in the mid-infrared to be detected in the observed fields. ISOCAM CVF observations provide spatially resolved observations (5'') of 151 wavelengths between 5.1 and 16.5 microns with a spectral resolution R = 35 to 50. We observe atomic emission lines ([Ne II], [Ne III], and [S IV]), several "unidentified infrared bands" (UIBs; 6.2, 7.7, 8.6, 11.3, 12.0, and 12.7 microns), and in some cases a continuum which rises steeply at longer wavelengths. We conclude that the spectra of these three GHRs are well explained by combinations of ionized gas, PAHs, and very small grains in various proportions and with different spatial distributions. Comparisons between observed ratios of the various UIBs with model ratios indicate that the PAHs in all three of the GHRs are dehydrogenated and that the small PAHs have been destroyed in IC 133 but have survived in NGC 595 and CC 93. The [Ne III]/[Ne II] ratios observed in IC 133 and NGC 595 are consistent with their ages of 5 and 4.5 Myr, respectively; the deduced ionization parameter is higher in IC 133, consistent with its more compact region of emission.

Starburst in the Interacting HII Galaxy II Zw 40 and in Non-Interacting HII Galaxies

NASA Astrophysics Data System (ADS)

Telles, E.

2010-06-01

In this poster, I summarize the results of our integral field spectroscopic observations of the nearby prototype of HII galaxies, II Zw 40. Observations with GMOS-IFU on GEMINI-North in the optical allowed us to make a detailed kinematic picture of the central starburst, while SINFONI with adaptive optics on the ESO-VLT gave us a near-IR view of the interplay between the ISM phases. Here, I also address the question that not all starbursts require an external trigger such as a galaxy-galaxy encounter, as it seems to be the case for a fraction of low luminosity HII galaxies. We speculate that these may form stars spontaneously like "popcorn in a pan".

Integral field spectroscopy of the two complexes of HII regions in the main galaxy of the minor merger AM2306-721

NASA Astrophysics Data System (ADS)

Hernandez-Jimenez, J. A.; Pastoriza, G.; Sanmartim, D.; Winge, C.; Bonatto, C.; Krabbe, A. C.; Rodrigues, I.

2017-07-01

We present a study of two complexes of HII regions in the main galaxy of minor merger AM 2306-721. The observations were obtained with the GMOS-IFU on the Gemini South telescope. By using different discrimination criteria, we determined that shock-ionized gas fraction ranges between 0% and 35%, which are in good agreement with numerical models. Thus, we conclude that almost all the mechanical energy from stellar winds and supernovae is being irradiated.

Photoevaporating Disks around Young Stars: Ultracompact HII Regions and Protoplanetary Disks.

NASA Astrophysics Data System (ADS)

Johnstone, Douglas Ian

1995-01-01

Newly formed stars produce sufficient Lyman continuum luminosity phi to significantly alter the structure and evolution of the accretion disk surrounding them. In the absence of a stellar wind, a nearly static, photoionized, 10^4 K, disk atmosphere, with a scale height that increases with disk radius varpi as varpi^{3/2 }, forms inside the gravitational radius varpig ~ 1014(M_*/ M_odot) cm where M _* is the mass of the central star. This ionized atmosphere is maintained by both the direct radiation from the central star and the diffuse field produced in the disk atmosphere by the significant fraction of hydrogen recombinations directly to the ground state. Beyond varpig the material evaporated from the disk is capable of escaping from the system and produces an ionized disk wind. The mass-loss due to this disk wind peaks at varpig . The inclusion of a stellar wind into the basic picture reduces the height of the inner disk atmosphere and introduces a new scale radius varpi_ {w} where the thermal pressure of the material evaporated from the disk balances the ram pressure in the wind. In this case the mass-loss due to the disk wind peaks at varpiw and is enhanced over the no-wind case. The photoevaporation of disks around newly formed stars has significance to both ultracompact HII regions and the dispersal of solar-type nebulae. High mass stars are intrinsically hot and thus yield sufficient Lyman luminosity to create, even without a stellar wind, disk mass-loss rates of order 2 times 10 ^{-5}phi_sp{49} {1/2} M_odotyr ^{-1}, where phi 49 = phi/(10 49 Lyman continuum photons s^{-1}). This wind, which will last until the disk is dispersed, ~ 10^5 yrs if the disk mass is M_ {d}~0.3M_*, yields sizes, emission measures and ages consistent with observations of ultracompact HII regions. The well-observed high mass star MWC 349 may be the best example to date of an evaporating disk around a high mass star. On the other end of the stellar scale, many newly formed low

Deuteration around the ultracompact HII region Monoceros R2

NASA Astrophysics Data System (ADS)

Treviño-Morales, S. P.; Pilleri, P.; Fuente, A.; Kramer, C.; Roueff, E.; González-García, M.; Cernicharo, J.; Gerin, M.; Goicoechea, J. R.; Pety, J.; Berné, O.; Ossenkopf, V.; Ginard, D.; García-Burillo, S.; Rizzo, J. R.; Viti, S.

2014-09-01

Context. The massive star-forming region Monoceros R2 (Mon R2) hosts the closest ultra-compact Hii region, where the photon-dominated region (PDR) between the ionized and molecular gas can be spatially resolved with current single-dish telescopes. Aims: We aim at studying the chemistry of deuterated molecules toward Mon R2 to determine the deuterium fractions around a high-UV irradiated PDR and investigate the chemistry of these species. Methods: We used the IRAM-30 m telescope to carry out an unbiased spectral survey toward two important positions (namely IF and MP2) in Mon R2 at 1, 2, and 3 mm. This spectral survey is the observational basis of our study of the deuteration in this massive star-forming region. Our high spectral resolution observations (~0.25-0.65 km s-1) allowed us to resolve the line profiles of the different species detected. Results: We found a rich chemistry of deuterated species at both positions of Mon R2, with detections of C2D, DCN, DNC, DCO+, D2CO, HDCO, NH2D, and N2D+ and their corresponding hydrogenated species and rarer isotopologs. The high spectral resolution of our observations allowed us to resolve three velocity components: the component at 10 km s-1 is detected at both positions and seems associated with the layer most exposed to the UV radiation from IRS 1; the component at 12 km s-1 is found toward the IF position and seems related to the foreground molecular gas; finally, a component at 8.5 km s-1 is only detected toward the MP2 position, most likely related to a low-UV irradiated PDR. We derived the column density of the deuterated species (together with their hydrogenated counterparts), and determined the deuterium fractions as Dfrac = [XD]/[XH]. The values of Dfrac are around 0.01 for all the observed species, except for HCO+ and N2H+, which have values 10 times lower. The values found in Mon R2 are similar to those measured in the Orion Bar, and are well explained with a pseudo-time-dependent gas-phase model in which

Beyond the Solar Circle - Tracing Trends in Massive Star Formation for the Inner and Outer Galaxy

NASA Astrophysics Data System (ADS)

Djordjevic, Julie; Thompson, Mark; Urquhart, James

2018-01-01

Observations towards nearby galaxies are biased towards massive stars, affecting simulations and typically overestimating models for galactic evolution and star formation rates. The Milky Way provides an ideal template for studying the key factors that affect these massive star formation rates and efficiencies at high resolution, fine-tuning those models. We examine trends in massive star formation through the Galactic distribution of compact and ultracompact HII regions (UC HII regions) identified and confirmed as genuine via multi-wavelength inspection of submillimeter, radio, and infrared survey data. Previous catalogs focused on the inner Galaxy (RGC ≤ 8.5 kpc) but results from the recently completed SASSy 850 µm survey with JCMT’s SCUBA-2 show potential star forming clumps out to ~20 kpc. We follow a similar approach to Urquhart et at. (2013) who compiled a catalog of UC HII regions by cross matching CORNISH 5 GHz data with ATLASGAL 870 µm and GLIMPSE 3-color images. The CORNISH survey, however, was limited to the range 10° < l < 60° . By utilizing the RMS radio and infrared catalogs which cover the entire Galactic plane, we can examine the remaining ATLASGAL regions (300° < l < 10° ) as well as the SASSy ranges (60° < l < 240°). With this method we more than doubled the sample size of the CORNISH study, finding a grand total of 539 embedded UC HII regions across the Galaxy. We derive their properties and also look at the parameters of the host clumps to determine the implications for massive star formation rates and efficiencies as a function of galactocentric radius. We find that there is no significant change in the rate of massive star formation in the outer vs inner Galaxy. However, many of the potentially star forming SASSy clumps have no available radio counterpart to confirm the presence of an HII region or other star formation tracer. This begs the question whether there really is less star formation in this area or whether simply a lack

Triggered massive star formation associated with the bubble Hii region Sh2-39 (N5)

NASA Astrophysics Data System (ADS)

Duronea, N. U.; Cappa, C. E.; Bronfman, L.; Borissova, J.; Gromadzki, M.; Kuhn, M. A.

2017-09-01

Aims: We perform a multiwavelength analysis of the bubble Hii region Sh2-39 (N5) and its environs with the aim of studying the physical properties of Galactic IR bubbles and exploring their impact in triggering massive star formation. Methods: To analyze the molecular gas, we used CO(3-2) and HCO+(4-3) line data obtained with the on-the-fly technique from the ASTE telescope. To study the distribution and physical characteristics of the dust, we made use of archival data from ATLASGAL, Herschel, and MSX, while the ionized gas was studied making use of an NVSS image. We used public WISE, Spitzer, and MSX point source catalogs to search for infrared candidate young stellar objects (YSOs) in the region. To investigate the stellar cluster [BDS2003]6 we used IR spectroscopic data obtained with the ARCoIRIS spectrograph, mounted on Blanco 4 m Telescope at CTIO, and new available IR Ks band observations from the VVVeXtended ESO Public Survey (VVVX). Results: The new ASTE observations allowed the molecular gas component in the velocity range from 30 km s-1 to 46 km s-1, associated with Sh2-39, to be studied in detail. The morphology of the molecular gas suggests that the ionized gas is expanding against its parental cloud. We identified four molecular clumps, which were likely formed by the expansion of the ionization front, and determined some of their physical and dynamical properties. Clumps with HCO+ and 870 μm counterparts show evidence of gravitational collapse. We identified several candidate YSOs across the molecular component. Their spatial distribution and the fragmentation time derived for the collected layers of the molecular gas suggest that massive star formation might have been triggered by the expansion of the nebula via the collect and collapse mechanism. The spectroscopical distance obtained for the stellar cluster [BDS2003]6, placed over one of the collapsing clumps in the border of the Hii region, reveals that this cluster is physically associated with

VLT near- to mid-IR imaging and spectroscopy of the M 17 UC1 - IRS5 region

NASA Astrophysics Data System (ADS)

Chen, Zhiwei; Nürnberger, Dieter E. A.; Chini, Rolf; Jiang, Zhibo; Fang, Min

2015-06-01

Aims: We investigate the surroundings of the hypercompact H ii region M 17 UC1 to probe the physical properties of the associated young stellar objects and the environment of massive star formation. Methods: We use diffraction-limited near-IR (VLT/NACO) and mid-IR (VLT/VISIR) images to reveal the different morphologies at various wavelengths. Likewise, we investigate the stellar and nebular content of the region with VLT/SINFONI integral field spectroscopy with a resolution R ˜ 1500 at H + K bands. Results: Five of the seven point sources in this region show L-band excess emission. A geometric match is found between the H2 emission and near-IR polarized light in the vicinity of IRS5A, and between the diffuse mid-IR emission and near-IR polarization north of UC1. The H2 emission is typical for dense photodissociation regions (PDRs), which are initially far-ultraviolet pumped and repopulated by collisional de-excitation. The spectral types of IRS5A and B273A are B3-B7 V/III and G4-G5 III, respectively. The observed infrared luminosity LIR in the range 1-20 μm is derived for three objects; we obtain 2.0 × 103 L⊙ for IRS5A, 13 L⊙ for IRS5C, and 10 L⊙ for B273A. Conclusions: IRS5 might be a young quadruple system. Its primary star IRS5A is confirmed to be a high-mass protostellar object (˜9 M⊙, ˜1 × 105 yrs); it might have terminated accretion due to the feedback from stellar activities (radiation pressure, outflow) and the expanding H ii region of M 17. The object UC1 might also have terminated accretion because of the expanding hypercompact H ii region, which it ionizes. The disk clearing process of the low-mass young stellar objects in this region might be accelerated by the expanding H ii region. The outflows driven by UC1 are running south-north with its northeastern side suppressed by the expanding ionization front of M 17; the blue-shifted outflow lobe of IRS5A is seen in two types of tracers along the same line of sight in the form of H2 emission

Different structures formed at HII boundaries

NASA Astrophysics Data System (ADS)

Miao, Jingqi; Cornwall, Paul; Kinnear, Tim

2015-03-01

Hydrodynamic simulations on the evolution of molecular clouds (MCs) at HII boundaries are used to show that radiation driven implosion (RDI) model can create almost all of the different morphological structures, such as a single bright-rimmed cloud (BRC), fragment structure and multiple elephant trunk (ET) structures.

The H-Impairment Index (HII): a standardized assessment of alcohol-induced impairment in the Emergency Department.

PubMed

Hack, Jason B; Goldlust, Eric J; Gibbs, Frantz; Zink, Brian

2014-03-01

Emergency Departments (EDs) care for thousands of alcohol-intoxicated patients annually. No clinically relevant bedside measures currently exist to describe degree of impairment. To assess a group of bedside tests ("Hack's Impairment Index [HII] score") that applies a numerical value to the degree of alcohol-induced impairment in ED patients. A six-month retrospective review of HII score data was performed in a convenience sample of 293 intoxicated ED patients. Patients were scored 0-4 on five tasks, divided by the maximum score (20 if all tasks completed), every 2 hours; and classified by the number of visits: Low-frequency (1 visit); Medium-frequency (2 visits); High-frequency (≥3 visits). Correlations were assessed between HII score, healthcare provider judgment of intoxication, and measured alcohol levels. Study patients had 513 visits; 236 were low-frequency, 26 middle-frequency and 31 high-frequency. Clinical assessment and HII score were strongly correlated (Spearman's rho = 0.82, p < 0.001); clinical assessment and alcohol level less strongly so (rho = 0.49, p < 0.001). Among low-frequency patients, HII score and alcohol level were weakly correlated (r = 0.324, p < 0.001), with no such correlation among high-frequency visitors (r = -0.04, p = 0.89). The mean decline between serial HII scores was 0.126 (95% CI: 0.098-0.154). This pilot study shows the HII score can be performed at the bedside of alcohol-intoxicated patients. The HII declines in a reasonably predictable manner over time; and applies a quantitative, objective assessment of alcohol impairment.

VizieR Online Data Catalog: IRX-β relation of HII regions in NGC628 (Ye+, 2016)

NASA Astrophysics Data System (ADS)

Ye, C.; Zou, H.; Lin, L.; Lian, J.; Hu, N.; Kong, X.

2016-10-01

NGC 628 has been observed by the PPAK IFS Nearby Galaxies Survey (PINGS) performed by the 3.5m telescope of the Calar Alto Observatory. The IFU provides a sampling of 2.7", an optical wavelength range of 3700-7000Å with a spectral resolution of ~8Å. The final data set comprises 11094 individual spectra, and the typical spatial resolution is about 3.5"-4". The slice image at the Hα wavelength is used to determine HII regions. FUV and near-UV (NUV) images of NGC 628 were taken by the Galaxy Evolution Explorer (GALEX), which are centered at wavelengths of 1516 and 2267Å. IR images were taken by Spitzer IRAC (3.6um, 8.0um) and MIPS (24um). The spatial resolutions of UV and IR images are 4.3", 5.3", 1.9", 2.8", and 6.4", respectively. We obtain these images from the data release website of Local Volume Legacy (LVL) survey DR5 (Dale+, 2009, J/ApJ/703/517; http://irsa.ipac.caltech.edu/data/SPITZER/LVL/). (2 data files).

Rotational Modulation and Activity Cycles at Rotational Extremes: 25 yrs of NURO Photometry for HII 1883

NASA Astrophysics Data System (ADS)

Milingo, Jackie; Saar, Steven; Marschall, Laurence

2018-01-01

We present a 25 yr compilation of V-band differential photometry for the Pleiades K dwarf HII 1883 (V660 Tau). HII 1883 has a rotational period of ~ 0.24 d and displays significant rotational modulation due to non-uniform surface brightness or "starspots". Preliminary work yields a cycle period of ~ 9 yrs and rotational shear (ΔP_rot/) considerably less than solar. HII 1883 is one of the fastest rotating single stars with a known cycle. With additional data available we compare newly determined P_cyc and ΔP_rot/ values with those of other stars, putting HII 1883 into the broader context of dynamo properties in single cool dwarfs.

Logistics support of the Japanese Experiment Module by the H-II rocket

NASA Astrophysics Data System (ADS)

Shibato, Yoji; Eto, Takao; Fukushima, Yukio; Takatsuka, Hitoshi

1988-10-01

This paper describes salient design features of the Japanese Experiment Module (JEM), which will be attached to the Space Station. Special attention is given to the logistic support of the JEM (which is planned to become operational in 1990s) by the HOPE orbiter, which will be used for the resupply and the retrieval of the JEM, and the H-II rocket, which will be used to launch the HOPE. The concepts of HOPE and the H-II rocket are discussed together with the estimated logistics requirements of this system. Configuration diagrams are included.

Estudo da região HII galática NGC 2579

NASA Astrophysics Data System (ADS)

Riffel, R.; Copetti, M. V. F.

2003-08-01

Desde a descoberta dos gradientes de abundância química em galáxias espirais, as regiões HII galáticas têm sido intensamente estudadas com o objetivo de determinar a forma do gradiente de abundância química na Via-Láctea. Entretanto, a forma do gradiente galático continua controversa e existem muitas regiões HII que continuam inexploradas. A região HII galática NGC 2579 é um objeto que aparece em imagens Ha, como uma pequena mancha brilhante de aproximadamente 2 segundos de arco de diâmetro a 20 segundos de arco ao leste de RCW 20, sendo NGC 2579 muitas vezes confundida com esta última. Apesar de seu alto brilho superficial, NGC 2579 é um objeto pouco estudado provavelmente por problemas de identificação deste objeto. Como parte de um projeto de reavaliação dos gradientes de abundância química das regiões HII na Via-Láctea, estamos realizando um estudo extensivo das propriedades físicas básicas como temperatura eletrônica, densidade eletrônica e composição química da região HII galática NGC 2579. Analisamos dados espectrofotométricos de fenda longa na faixa de 3700Å a 7750Å obtidos com o telescópio de 1.52 m do ESO, Chile, em 2002. Determinamos a temperatura eletrônica usando a razão entre as linhas do [OIII] (l4959+l5007/l4363) e a densidade eletrônica pela razão entre as linhas do [SII] (l6716/l6731). As abundâncias químicas do O, N, Cl, S, Ne e He foram determinadas. Realizamos um estudo de imagens fotométricas nas bandas UBVRI obtidas em 2000 no observatório astronômico San Pedro Mártir, México, para identificar e classificar as estrelas ionizantes de NGC 2579 e determinar a distância deste objeto.

Finding Distant Galactic HII Regions

NASA Astrophysics Data System (ADS)

Anderson, L. D.; Armentrout, W. P.; Johnstone, B. M.; Bania, T. M.; Balser, Dana S.; Wenger, Trey V.; Cunningham, V.

2015-12-01

The WISE Catalog of Galactic H ii Regions contains ˜2000 H ii region candidates lacking ionized gas spectroscopic observations. All candidates have the characteristic H ii region mid-infrared morphology of WISE 12 μ {{m}} emission surrounding 22 μ {{m}} emission, and additionally have detected radio continuum emission. We here report Green Bank Telescope hydrogen radio recombination line and radio continuum detections in the X-band (9 GHz; 3 cm) of 302 WISE H ii region candidates (out of 324 targets observed) in the zone 225^\\circ ≥slant {\\ell }≥slant -20^\\circ , | {\\text{}}b| ≤slant 6^\\circ . Here we extend the sky coverage of our H ii region Discovery Survey, which now contains nearly 800 H ii regions distributed across the entire northern sky. We provide LSR velocities for the 302 detections and kinematic distances for 131 of these. Of the 302 new detections, 5 have ({\\ell },{\\text{}}b,v) coordinates consistent with the Outer Scutum-Centaurus Arm (OSC), the most distant molecular spiral arm of the Milky Way. Due to the Galactic warp, these nebulae are found at Galactic latitudes >1° in the first Galactic quadrant, and therefore were missed in previous surveys of the Galactic plane. One additional region has a longitude and velocity consistent with the OSC but lies at a negative Galactic latitude (G039.183-01.422 -54.9 {km} {{{s}}}-1). With Heliocentric distances >22 kpc and Galactocentric distances >16 kpc, the OSC H ii regions are the most distant known in the Galaxy. We detect an additional three H ii regions near {\\ell }≃ 150^\\circ whose LSR velocities place them at Galactocentric radii >19 kpc. If their distances are correct, these nebulae may represent the limit to Galactic massive star formation.

UNC-45/CRO1/She4p (UCS) Protein Forms Elongated Dimer and Joins Two Myosin Heads Near Their Actin Binding Region

DOE Office of Scientific and Technical Information (OSTI.GOV)

H Shi; G Blobel

2011-12-31

UNC-45/CRO1/She4p (UCS) proteins have variously been proposed to affect the folding, stability, and ATPase activity of myosins. They are the only proteins known to interact directly with the motor domain. To gain more insight into UCS function, we determined the atomic structure of the yeast UCS protein, She4p, at 2.9 {angstrom} resolution. We found that 16 helical repeats are organized into an L-shaped superhelix with an amphipathic N-terminal helix dangling off the short arm of the L-shaped molecule. In the crystal, She4p forms a 193-{angstrom}-long, zigzag-shaped dimer through three distinct and evolutionary conserved interfaces. We have identified She4p's C-terminal regionmore » as a ligand for a 27-residue-long epitope on the myosin motor domain. Remarkably, this region consists of two adjacent, but distinct, binding epitopes localized at the nucleotide-responsive cleft between the nucleotide- and actin-filament-binding sites. One epitope is situated inside the cleft, the other outside the cleft. After ATP hydrolysis and Pi ejection, the cleft narrows at its base from 20 to 12 {angstrom} thereby occluding the inside the cleft epitope, while leaving the adjacent, outside the cleft binding epitope accessible to UCS binding. Hence, one cycle of higher and lower binding affinity would accompany one ATP hydrolysis cycle and a single step in the walk on an actin filament rope. We propose that a UCS dimer links two myosins at their motor domains and thereby functions as one of the determinants for step size of myosin on actin filaments.« less

The development of H-II rocket solid rocket booster thrust vector control system

NASA Astrophysics Data System (ADS)

Nagai, Hirokazu; Fukushima, Yukio; Kazama, Hiroo; Asai, Tatsuro; Okaya, Shunichi; Watanabe, Yasushi; Muramatsu, Shoji

The development of the thrust-vector-control (TVC) system for the two solid rocket boosters (SRBs) of the H-II rocket, which was started in 1984 and completed in 1989, is described. Special attention is given to the system's design, the trade-off studies, and the evaluation of the SRB-TVC system performance, as well as to problems that occurred in the course of the system's development and to the countermeasures that were taken. Schematic diagrams are presented for the H-II rocket, the SRB, and the SRB-TVC system configurations.

Water masers in NGC7538 region

NASA Astrophysics Data System (ADS)

Kameya, Osamu

We observed H2O masers towards NGC7538 molecular-cloud core using VERA (VLBI Experiment of Radio Astrometry). This region is in the Perseus arm at a distance of about 2.7 kpc and is famous for its multiple, massive star formation. There are three areas there, N(IRS1-3), E(IRS9), and S(IRS11), each having a strong IR source(s), ultra-compact HII region(s), bipolar outflow, high-density core, and OH/H2O/CH3OH masers. We made differential VLBI observations towards the NGC7538 H2O maser sources at N and S and a reference source, Cepheus A H2O maser, simultaneously. The Cepheus A region is separated by 2 degrees from the NGC7538 region. The positions of H2O masers in N and S regions, distributed around the ultra-compact HII regions, are basically consistent with those found by means of interferometric observations of past 29 years. The masers may come from interface regions between the ultra-compact HII regions and the environments of dense molecular gas.

Probing the Galactic Structure of the Milky Way with H II Regions

NASA Astrophysics Data System (ADS)

Red, Wesley Alexander; Wenger, Trey V.; Balser, Dana; Anderson, Loren; Bania, Thomas

2018-01-01

Mapping the structure of the Milky Way is challenging since we reside within the Galactic disk and distances are difficult to determine. Elemental abundances provide important constraints on theories of the formation and evolution of the Milky Way. HII regions are the brightest objects in the Galaxy at radio wavelengths and are detected across the entire Galactic disk. We use the Jansky Very Large Array (VLA) to observe the radio recombination line (RRL) and continuum emission of 120 Galactic HII regions located across the Galactic disk. In thermal equilibrium, metal abundances are expected to set the nebular electron temperature with high abundances producing low temperatures. We derive the metallicity of HII regions using an empirical relation between an HII region's radio recombination line-to-continuum ratio and nebular metallicity. Here we focus on a subset of 20 HII regions from our sample that have been well studied with the Green Bank Telescope (GBT) to test our data reduction pipeline and analysis methods. Our goal is to expand this study to the Southern skies with the Australia Telescope Compact Array and create a metallicity map of the entire Galactic disk.

Kinematic Study of Ionized and Molecular Gases in Ultracompact HII Region in Monoceros R2

NASA Astrophysics Data System (ADS)

Kim, Hwihyun; Lacy, John H.; Jaffe, Daniel Thomas

2017-06-01

Monoceros R2 (Mon R2) is an UltraCompact HII region (UCHII) surrounded by several PhotoDissociation Regions (PDRs). It is an excellent example to investigate the chemistry and physics of early stage of massive star formation due to its proximity (830pc) and brightness. Previous studies suggest that the wind from the star holds the ionized gas up against the dense molecular core and the higher pressure at the head drives the ionized gas along the shell. In order for the model to work, there should be evidence for dense molecular gas along the shell walls, irradiated by the UCHII region and perhaps entrained into the flow along the walls.We obtained the Immersion Grating INfrared Spectrograph (IGRINS) spectra of Mon R2 to study the kinematic patterns in the areas where ionized and molecular gases interact. The position-velocity maps from the high resolution (R~45,000) H- and K-band (1.4-2.5μm) IGRINS spectra demonstrate that the ionized gases (Brackett and Pfund series, He and Fe emission lines; Δv ≈ 40km/s) flow along the walls of the surrounding clouds. This is consistent with the model by Zhu et al. (2008). In the PV maps of the H2 emission lines there is no obvious motion (Δv ≈ 10km/s) of the molecular hydrogen right at the ionization boundary. This implies that the molecular gas is not taking part in the flow as the ionized gas is moving along the cavity walls.This work used the Immersion Grating Infrared Spectrograph (IGRINS) that was developed under a collaboration between the University of Texas at Austin and the Korea Astronomy and Space Science Institute (KASI) with the financial support of the US National Science Foundation (NSF; grant AST-1229522), of the University of Texas at Austin, and of the Korean GMTProject of KASI.

Genetic characterization of the UCS and Kex1 loci of Pneumocystis jirovecii.

PubMed

Esteves, F; Tavares, A; Costa, M C; Gaspar, J; Antunes, F; Matos, O

2009-02-01

Nucleotide variation in the Pneumocystis jirovecii upstream conserved sequence (UCS) and kexin-like serine protease (Kex1) loci was studied in pulmonary specimens from Portuguese HIV-positive patients. DNA was extracted and used for specific molecular sequence analysis. The number of UCS tandem repeats detected in 13 successfully sequenced isolates ranged from three (9 isolates, 69%) to four (4 isolates, 31%). A novel tandem repeat pattern and two novel polymorphisms were detected in the UCS region. For the Kex1 gene, the wild-type (24 isolates, 86%) was the most frequent sequence detected among the 28 sequenced isolates. Nevertheless, a nonsynonymous (1 isolate, 3%) and three synonymous (3 isolates, 11%) polymorphisms were detected and are described here for the first time.

Molecular theory of lipid-protein interaction and the Lalpha-HII transition.

PubMed Central

May, S; Ben-Shaul, A

1999-01-01

We present a molecular-level theory for lipid-protein interaction and apply it to the study of lipid-mediated interactions between proteins and the protein-induced transition from the planar bilayer (Lalpha) to the inverse-hexagonal (HII) phase. The proteins are treated as rigid, membrane-spanning, hydrophobic inclusions of different size and shape, e.g., "cylinder-like," "barrel-like," or "vase-like." We assume strong hydrophobic coupling between the protein and its neighbor lipids. This means that, if necessary, the flexible lipid chains surrounding the protein will stretch, compress, and/or tilt to bridge the hydrophobic thickness mismatch between the protein and the unperturbed bilayer. The system free energy is expressed as an integral over local molecular contributions, the latter accounting for interheadgroup repulsion, hydrocarbon-water surface energy, and chain stretching-tilting effects. We show that the molecular interaction constants are intimately related to familiar elastic (continuum) characteristics of the membrane, such as the bending rigidity and spontaneous curvature, as well as to the less familiar tilt modulus. The equilibrium configuration of the membrane is determined by minimizing the free energy functional, subject to boundary conditions dictated by the size, shape, and spatial distribution of inclusions. A similar procedure is used to calculate the free energy and structure of peptide-free and peptide-rich hexagonal phases. Two degrees of freedom are involved in the variational minimization procedure: the local length and local tilt angle of the lipid chains. The inclusion of chain tilt is particularly important for studying noncylindrical (for instance, barrel-like) inclusions and analyzing the structure of the HII lipid phase; e.g., we find that chain tilt relaxation implies strong faceting of the lipid monolayers in the hexagonal phase. Consistent with experiment, we find that only short peptides (large negative mismatch) can induce the

Populações estelares em galáxias HII

NASA Astrophysics Data System (ADS)

Westera, P.; Cuisinier, F.; Telles, E.; Kehrig, C.

2003-08-01

Analisamos o conteúdo estelar de 74 galáxias HII a partir do contínuo observado nos espectros ópticos dessas galáxias, utilizando métodos de síntese de população estelar. Descobrimos que todas as galáxias para as quais encontramos soluções contêm uma população estelar velha que domina a massa estelar, e numa maioria dessas também encontramos evidência de uma população de idade intermediaria além da geração jovem que está se formando agora. Concluímos que a formação estelar dessas galáxias se realiza em surtos individuais, Esses surtos são interrompidos por longos períodos de inatividade, com os primeiros consumindo a maior parte do gás. Sugerimos, portanto, que as galáxias HII sejam galáxias anãs normais flagradas em um período de surto.

Lactobacillus paracasei HII01, xylooligosaccharides, and synbiotics reduce gut disturbance in obese rats.

PubMed

Thiennimitr, Parameth; Yasom, Sakawdaurn; Tunapong, Wannipa; Chunchai, Titikorn; Wanchai, Keerati; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Sirilun, Sasithorn; Chaiyasut, Chaiyavat; Chattipakorn, Nipon; Chattipakorn, Siriporn C

2018-03-20

The beneficial effects of pro-, pre-, and synbiotics on obesity with insulin resistance have been reported previously. However, the strain-specific effect of probiotics and the combination with various types of prebiotic fiber yield controversial outcomes and limit clinical applications. Our previous study demonstrated that the probiotic Lactobacillus paracasei (L. paracasei) HII01, prebiotic xylooligosaccharide (XOS), and synbiotics share similar efficacy in attenuating cardiac mitochondrial dysfunction in obese-insulin resistant rats. Nonetheless, the roles of HII01 and XOS on gut dysbiosis and gut inflammation under obese-insulin resistant conditions have not yet, to our knowledge, been investigated. Our hypothesis was that pro-, pre-, and synbiotics improve the metabolic parameters in obese-insulin resistant rats by reducing gut dysbiosis and gut inflammation. Male Wistar rats were fed with either a normal or high-fat diet that contained 19.77% and 59.28% energy from fat, respectively, for 12 wk. Then, the high-fat diet rats were fed daily with a 10 8 colony forming unit of the probiotic HII01, 10% prebiotic XOS, and synbiotics for 12 wk. The metabolic parameters, serum lipopolysaccharide levels, fecal Firmicutes/Bacteroidetes ratios, levels of Enterobacteriaceae, Bifidobacteria, and gut proinflammatory cytokine gene expression were quantified. The consumption of probiotic L. paracasei HII01, prebiotic XOS, and synbiotics for 12 wk led to a decrease in metabolic endotoxemia, gut dysbiosis (a reduction in the Firmicutes/Bacteroidetes ratio and Enterobacteriaceae), and gut inflammation in obese-insulin resistant rats. Pro-, pre-, and synbiotics reduced gut dysbiosis and gut inflammation, which lead to improvements in metabolic dysfunction in obese-insulin resistant rats. Copyright © 2018 Elsevier Inc. All rights reserved.

The GAN Exonuclease or the Flap Endonuclease Fen1 and RNase HII Are Necessary for Viability of Thermococcus kodakarensis.

PubMed

Burkhart, Brett W; Cubonova, Lubomira; Heider, Margaret R; Kelman, Zvi; Reeve, John N; Santangelo, Thomas J

2017-07-01

Many aspects of and factors required for DNA replication are conserved across all three domains of life, but there are some significant differences surrounding lagging-strand synthesis. In Archaea , a 5'-to-3' exonuclease, related to both bacterial RecJ and eukaryotic Cdc45, that associates with the replisome specifically through interactions with GINS was identified and designated GAN (for G INS- a ssociated n uclease). Despite the presence of a well-characterized flap endonuclease (Fen1), it was hypothesized that GAN might participate in primer removal during Okazaki fragment maturation, and as a Cdc45 homologue, GAN might also be a structural component of an archaeal CMG (Cdc45, MCM, and GINS) replication complex. We demonstrate here that, individually, either Fen1 or GAN can be deleted, with no discernible effects on viability and growth. However, deletion of both Fen1 and GAN was not possible, consistent with both enzymes catalyzing the same step in primer removal from Okazaki fragments in vivo RNase HII has also been proposed to participate in primer processing during Okazaki fragment maturation. Strains with both Fen1 and RNase HII deleted grew well. GAN activity is therefore sufficient for viability in the absence of both RNase HII and Fen1, but it was not possible to construct a strain with both RNase HII and GAN deleted. Fen1 alone is therefore insufficient for viability in the absence of both RNase HII and GAN. The ability to delete GAN demonstrates that GAN is not required for the activation or stability of the archaeal MCM replicative helicase. IMPORTANCE The mechanisms used to remove primer sequences from Okazaki fragments during lagging-strand DNA replication differ in the biological domains. Bacteria use the exonuclease activity of DNA polymerase I, whereas eukaryotes and archaea encode a flap endonuclease (Fen1) that cleaves displaced primer sequences. RNase HII and the GINS-associated exonuclease GAN have also been hypothesized to assist in primer

Development of a UC781 releasing polyethylene vinyl acetate vaginal ring.

PubMed

McConville, Christopher; Major, Ian; Friend, David R; Clark, Meredith R; Malcolm, R Karl

2012-12-01

UC781 is potent, hydrophobic, non-nucleotide reverse transcriptase inhibitor (NNRTI) against the human immunodeficiency virus (HIV). UC781 is currently being investigated for use as a potential HIV microbicide. A study in rhesus macaques demonstrated that a 100-mg UC781-loaded silicone elastomer vaginal ring released limited amounts of UC781 into the vaginal fluid and tissue after 28 days. The reason for this was due to the hydrophobic nature and limited aqueous solubility of UC781. This study describes the manufacture of UC781-loaded polyethylene vinyl acetate (PEVA) vaginal rings, which have an improved in vitro release rate of UC781 when compared to UC781-loaded silicone elastomer vaginal rings. The study demonstrates that the UC781 in the PEVA rings is mostly in its amorphous form due to the rings being manufactured above UC781's melting point. Furthermore, the rings do not show any signs of UC781 degradation, such as the presence of UC22.

Expression characteristics of long noncoding RNA uc.322 and its effects on pancreatic islet function.

PubMed

Zhao, Xiaoqin; Rong, Can; Pan, Fenghui; Xiang, Lizhi; Wang, Xinlei; Hu, Yun

2018-06-28

Increasing evidence indicates that long noncoding RNAs (lncRNAs) perform special biological functions by regulating gene expression through multiple pathways and molecular mechanisms. The aim of this study was to explore the expression characteristics of lncRNA uc.322 in pancreatic islet cells and its effects on the secretion function of islet cells. Bioinformatics analysis was used to detect the lncRNA uc.322 sequence, location, and structural features. Expression of lncRNA uc.322 in different tissues was detected by quantitative polymerase chain reaction analyses. Quantitative polymerase chain reaction, Western blot analysis, adenosine triphosphate determination, glucose-stimulated insulin secretion, and enzyme-linked immunosorbent assay were used to evaluate the effects of lncRNA uc.322 on insulin secretion. The results showed that the full-length of lncRNA uc.322 is 224 bp and that it is highly conserved in various species. Bioinformatics analysis revealed that lncRNA uc.322 is located on chr7:122893196-122893419 (GRCH37/hg19) within the SRY-related HMG-box 6 gene exon region. Compared with other tissues, lncRNA uc.322 is highly expressed in pancreatic tissue. Upregulation of lncRNA uc.322 expression increases the insulin transcription factors pancreatic and duodenal homeobox 1 and Forkhead box O1 expression, promotes insulin secretion in the extracellular fluid of Min6 cells, and increases the adenosine triphosphate concentration. On the other hand, knockdown of lncRNA uc.322 has opposite effects on Min6 cells. Overall, this study showed that upregulation of lncRNA uc.322 in islet β-cells can increase the expression of insulin transcription factors and promote insulin secretion, and it may be a new therapeutic target for diabetes. © 2018 Wiley Periodicals, Inc.

Vibration test of 1/5 scale H-II launch vehicle

NASA Astrophysics Data System (ADS)

Morino, Yoshiki; Komatsu, Keiji; Sano, Masaaki; Minegishi, Masakatsu; Morita, Toshiyuki; Kohsetsu, Y.

In order to predict dynamic loads on the newly designed Japanese H-II launch vehicle, the adequacy of prediction methods has been assessed by the dynamic scale model testing. The three-dimensional dynamic model was used in the analysis to express coupling effects among axial, lateral (pitch and yaw) and torsional vibrations. The liquid/tank interaction was considered by use of a boundary element method. The 1/5 scale model of the H-II launch vehicle was designed to simulate stiffness and mass properties of important structural parts, such as core/SRB junctions, first and second stage Lox tanks and engine mount structures. Modal excitation of the test vehicle was accomplished with 100-1000 N shakers which produced random or sinusoidal vibrational forces. The vibrational response of the test vehicle was measured at various locations with accelerometers and pressure sensor. In the lower frequency range, corresmpondence between analysis and experiment was generally good. The basic procedures in analysis seem to be adequate so far, but some improvements in mathematical modeling are suggested by comparison of test and analysis.

UCS-PROMOVE: The engineer of the future

NASA Astrophysics Data System (ADS)

Villas-Boas, V.

2010-06-01

The Universidade de Caxias do Sul (UCS) elaborated the cooperative project called 'The engineer of the future', with the objective of promoting science and engineering among high school teachers and students. This project aims to improve the quality of the teaching and to increase the interest of students in technological areas, leading to a future career in engineering. The activities of this project were planned to give meaning and foundation to the teaching-learning process of science and for the application of theory in the solution of real problems, while articulating scientific, economic, environmental, social and political aspects and also to reinforce the important role of engineering in society. Amongst the activities to be offered to high school teachers and students are a specialisation course for teachers based upon new educational methodologies, workshops in different areas of science and technology, a programme entitled 'Encouraging girls in technology, science and engineering', science fairs and visits to the industries of the region. Activities with the engineering instructors of UCS are also being developed in order to help them to incorporate in their classes more effective pedagogical strategies for educating the engineer-to-be.

A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis

PubMed Central

Chen, Lijian; Liu, Meiling; Zhang, Nan; Zhang, Li; Luo, Yuanwei; Liu, Zhenzhong; Dai, Lijun; Jiang, Yiguo

2016-01-01

As a common toxic metal, lead has significant neurotoxicity to brain development. Long non-coding RNAs (lncRNAs) function in multiple biological processes. However, whether lncRNAs are involved in lead-induced neurotoxicity remains unclear. Uc.173 is a lncRNA from a transcribed ultra-conservative region (T-UCR) of human, mouse and rat genomes. We established a lead-induced nerve injury mouse model. It showed the levels of Uc.173 decreased significantly in hippocampus tissue and serum of the model. We further tested the expression of Uc.173 in serum of lead-exposed children, which also showed a tendency to decrease. To explore the effects of Uc.173 on lead-induced nerve injury, we overexpressed Uc.173 in an N2a mouse nerve cell line and found Uc.173 had an inhibitory effect on lead-induced apoptosis of N2a. To investigate the molecular mechanisms of Uc.173 in apoptosis associated with lead-induced nerve injury, we predicted the target microRNAs of Uc.173 by using miRanda, TargetScan and RegRNA. After performing quantitative real-time PCR and bioinformatics analysis, we showed Uc.173 might inter-regulate with miR-291a-3p in lead-induced apoptosis and regulate apoptosis-associated genes. Our study suggests Uc.173 significantly inhibits the apoptosis of nerve cells, which may be mediated by inter-regulation with miRNAs in lead-induced nerve injury. PMID:26683706

Light atom quantum oscillations in UC and US

DOE PAGES

Yiu, Yuen; Aczel, Adam A.; Granroth, Garrett E.; ...

2016-01-19

High energy vibrational scattering in the binary systems UC and US is measured using time-of-flight inelastic neutron scattering. A clear set of well-defined peaks equally separated in energy is observed in UC, corresponding to harmonic oscillations of the light C atoms in a cage of heavy U atoms. The scattering is much weaker in US and only a few oscillator peaks are visible. We show how the difference between the materials can be understood by considering the neutron scattering lengths and masses of the lighter atoms. Monte Carlo ray tracing is used to simulate the scattering, with near quantitative agreementmore » with the data in UC, and some differences with US. The possibility of observing anharmonicity and anisotropy in the potentials of the light atoms is investigated in UC. Lastly, the observed data is well accounted for by considering each light atom as a single atom isotropic quantum harmonic oscillator.« less

Disposition and metabolism of 2,3-( UC)dichloropropene in rats after inhalation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bond, J.A.; Medinsky, M.A.; Dutcher, J.S.

1985-01-01

2,3-Dichloropropene (2,3-DCP) is a constituent of some commercially available preplant soil fumigants for the control of plant parasitic nematodes. The purpose of this investigation was to determine the disposition and metabolism of 2,3-( UC)DCP in rats after inhalation. Male Fischer-344 rats were exposed nose-only to a vapor concentration of 250 nmol 2,3-( UC)DCP/liter air (7.5 ppm; 25C, 620 Torr) for 6 hr. Blood samples were taken during exposure, and urine, feces, expired air, and tissues were collected for up to 65 hr after exposure. Urinary excretion was the major route of elimination of UC (55% of estimated absorbed 2,3-DCP). Half-timemore » for elimination of UC in urine was 9.8 +/- 0.05 hr (anti x +/- SE). Half-time for elimination of UC feces (17% of absorbed 2,3-DCP) was 12.9 +/- 0.14 hr (anti x +/- SE). Approximately 1 and 3% of the estimated absorbed 2,3-( UC)DCP were exhaled as either 2,3-( UC)DCP or UCO2, respectively. Concentrations of UC in blood increased during 240 min of exposure, after which no further increases in blood concentration of UC were seen. UC was widely distributed in tissues analyzed after a 6-hr exposure of rats to 2,3-( UC)DCP. Urinary bladder (150 nmol/g), nasal turbinates (125 nmol/g), kidneys (84 nmol/g), small intestine (61 nmol/g), and liver (35 nmol/g) were tissues with the highest concentrations of UC immediately after exposure. Over 90% of the UC in tissues analyzed was 2,3-DCP metabolites. Half-times for elimination of UC from tissues examined ranged from 3 to 11 hr. The data from this study indicate that after inhalation 2,3-DCP is metabolized in tissues and readily excreted. 21 references. 2 figures, 4 tables.« less

DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC).

PubMed

Arasaradnam, Ramesh P; Khoo, Kevin; Bradburn, Mike; Mathers, John C; Kelly, Seamus B

2010-07-01

Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and no studies exist that assess its relationship with lifestyle exposures. The methylation level of both ESR-1 and N-33 genes were significantly higher in UC subjects compared with controls (7.9% vs. 5.9%; p = 0.015 and 66% vs. 9.3%; p < 0.001 respectively). There was no detectable difference in global DNA methylation between patients with UC and age and sex matched controls. No associations between indices of DNA methylation and anthropometric measures or smoking patterns were detected. To assess genomic methylation and promoter methylation of the ESR-1 (oestrogen receptor-1) and N-33 (tumor suppressor candidate-3) genes in the macroscopically normal mucosa of UC patients as well as to investigate effects of anthropometric and lifestyle exposures on DNA methylation. Sixty eight subjects were recruited (24 UC and 44 age and sex matched controls). Colorectal mucosal biopsies were obtained and DNA was extracted. Genomic DNA methylation was quantified using the tritium-labelled cytosine extension assay (3[H] dCTP) while gene specific methylation was quantified using the COBRA method. For the first time, we have shown increased methylation in the promoter regions of the putative tumor suppressor gene N-33 in macroscopically normal mucosa of patients with UC. In addition, we have confirmed that methylation of ESR-1 promoter is higher in UC patients compared with age and sex matched controls. These findings suggest that inactivation through methylation of the putative tumor suppressor genes N-33 and ESR-1 may not be associated with colorectal carcinogenesis in UC.

Physical Conditions in Low Ionization Regions of the Orion Nebula

NASA Technical Reports Server (NTRS)

Baldwin, J. A.; Crotts, A.; DuFour, R. J.; Ferland, G. J.; Heathcote, S.; Hester, J. J.; Korista, K. T.; Martin, P. J.; ODell, C. R.

1996-01-01

We reexamine the spectroscopic underpinnings of recent claims that low ionization (O(I)) and (Fe(II)) lines from the Orion H(II) region are produced in a region where the iron-carrying grains have been destroyed and the electron density is surprisingly high. Our new HST and CTIO observations show that previous reported detections of(O(I)) lambda 5577 were strongly affected by telluric emission. Our line limits consistent with a moderate density (approx. 10(exp 4)/cu. cm photoionized gas. We show that a previously proposed model of the Orion H(II) region reproduces the observed (O(I)) and (Fe(II)) spectrum. These lines are fully consistent with formation in a moderate density dusty region.

9th Annual UC Systemwide Bioengineering Symposium

DTIC Science & Technology

2008-08-01

Morikis UCR CHUNSHENG WANG University of California San Francisco Christopher Druzgalski PAHCE Jeffrey Chen UC Riverside BRITE Adriana Aguirre UC...Diagnosis B23 Foad Mashayekhi, Aaron S. Meyer, Stacey A. Shiigi, Vu Nguyen and Daniel T. Ka - 129 meL UCLA B24 Self-Assembly and DNA Binding Properties of...Journal of Immunclogy 165:3839­ 3848. 2Hannan JP, Young KA , Guthrid!le JM, Asokan R, Szakonyi G, Chen XJS, & Holers \\1M (2005) Journal of Molecular

Rotational Rehybridization and the High Temperature Phase of UC2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wen, Xiaodong; Rudin, Sven P.; Batista, Enrique R.

2012-12-03

The screened hybrid approximation (HSE) of density functional theory (DFT) is used to examine the structural, optical, and electronic properties of the high temperature phase, cubic UC(2). This phase contains C(2) units with a computed C-C distance of 1.443 Å which is in the range of a CC double bond; U is formally 4+, C(2) 4-. The closed shell paramagnetic state (NM) was found to lie lowest. Cubic UC(2) is found to be a semiconductor with a narrow gap, 0.4 eV. Interestingly, the C(2) units connecting two uranium sites can rotate freely up to an angle of 30°, indicating amore » hindered rotational solid. Ab-initio molecular dynamic simulations (HSE) show that the rotation of C(2) units in the low temperature phase (tetragonal UC(2)) occurs above 2000 K, in good agreement with experiment. The computed energy barrier for the phase transition from tetragonal UC(2) to cubic UC(2) is around 1.30 eV per UC(2). What is fascinating about this system is that at high temperature, the phase transformation to the cubic phase is associated with a rehybridization of the C atoms from sp to sp(3).« less

The UC2-x - Carbon eutectic: A laser heating study

NASA Astrophysics Data System (ADS)

Manara, D.; Boboridis, K.; Morel, S.; De Bruycker, F.

2015-11-01

The UC2-x - carbon eutectic has been studied by laser heating and fast multi-wavelength pyrometry under inert atmosphere. The study has been carried out on three compositions, two of which close to the phase boundary of the UC2-x - C miscibility gap (with C/U atomic ratios 2 and 2.1), and one, more crucial, with a large excess of carbon (C/U = 2.82). The first two compositions were synthesised by arc-melting. This synthesis method could not be applied to the last composition, which was therefore completed directly by laser irradiation. The U - C - O composition of the samples was checked by using a combustion method in an ELTRA® analyser. The eutectic temperature, established to be 2737 K ± 20 K, was used as a radiance reference together with the cubic - tetragonal (α → β) solid state transition, fixed at 2050 K ± 20 K. The normal spectral emissivity of the carbon-richer compounds increases up to 0.7, whereas the value 0.53 was established for pure hypostoichiometric uranium dicarbide at the limit of the eutectic region. This increase is analysed in the light of the demixing of excess carbon, and used for the determination of the liquidus temperature (3220 K ± 50 K for UC2.82). Due to fast solid state diffusion, also fostered by the cubic - tetragonal transition, no obvious signs of a lamellar eutectic structure could be observed after quenching to room temperature. The eutectic surface C/UC2-x composition could be qualitatively, but consistently, followed during the cooling process with the help of the recorded radiance spectra. Whereas the external liquid surface is almost entirely constituted by uranium dicarbide, it gets rapidly enriched in demixed carbon upon freezing. Demixed carbon seems to quickly migrate towards the inner bulk during further cooling. At the α → β transition, uranium dicarbide covers again the almost entire external surface.

A Chandra X-ray Mosaic of the Onsala 2 Star-Forming Region

NASA Astrophysics Data System (ADS)

Skinner, Steve L.; Sokal, Kimberly; Guedel, Manuel

2018-01-01

Multiple lines of evidence for active high-mass star-formation in the Onsala 2 (ON2) complex in Cygnus include masers, compact HII (cHII) regions, and massive outflows. ON2 is thought to be physically associated with the young stellar cluster Berkeley 87 which contains several optically-identified OB stars and the rare oxygen-type (WO) Wolf-Rayet star WR 142. WO stars are undergoing advanced nuclear core burning as they approach the end of their lives as supernovae, and only a few are known in the Galaxy. We present results of a sensitive 70 ks Chandra ACIS-I observation of the northern half of ON2 obtained in 2016. This new observation, when combined with our previous 70 ks ACIS-I observation of the southern half in 2009, provides a complete X-ray mosaic of ON2 at arcsecond spatial resolution and reveals several hundred X-ray sources. We will summarize key results emerging from our ongoing analysis including the detection of an embedded population of young stars revealed as a tight grouping of X-ray sources surrounding the cHII region G75.77+0.34, possible diffuse X-ray emission (or unresolved faint point sources) near the cHII region G75.84+0.40, and confirmation of hard heavily-absorbed X-ray emission from WR 142 that was seen in the previous 2009 Chandra observation.

Perfis de temperatura eletrônica em regiões HII

NASA Astrophysics Data System (ADS)

Copetti, M. V. F.

2003-08-01

As flutuações de temperatura eletrônica em regiões HII, inicialmente propostas para explicar as discrepâncias entre os valores de temperatura obtidos por diferentes métodos, têm sido apontadas como a causa mais provável das enormes diferenças encontradas entre as abundâncias químicas medidas através de linhas excitadas colisionalmente e de linhas de recombinação. Recentemente têm sido reportadas tentativas de detecção e quantificação diretas das flutuações de temperatura eletrônica através de medidas ponto a ponto, obtidas por meio de espectroscopia de fenda longa, das razões de linhas [OIII]l4263/l5007 e [NII]l5755/l6584, principais sensores de temperatura. Neste trabalho, utilizamos o código numérico de fotoionização Cloudy para avaliar a confiabilidade desse procedimento. Concluímos que, para valores de densidade eletrônica e de temperatura efetiva da estrela ionizante típicos das regiões HII, os perfis superficiais de temperatura obtidos via medidas do sensor [OIII]l4263/l5007 são bons traçadores dos gradientes internos de temperatura eletrônica. Já os perfis de temperatura eletrônica medidos por meio da razão [NII]l5755/l6584 não reproduzem os gradientes verdadeiros de temperatura.

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions.

PubMed

Damian, Festo; Fabian, Judit; Friend, David R; Kiser, Patrick F

2010-08-30

In this work, we evaluated the chemical stability profiles of UC781 based solutions to identify excipients that stabilize the microbicidal agent UC781. When different antioxidants were added to UC781 in sulfobutylether-beta-cyclodextrin (SBE-beta-CD) solutions and subjected to a 50 degrees C stability study, it was observed that EDTA was a better stabilizing agent than sodium metabisulfite, glutathione or ascorbic acid. Some antioxidants accelerated the degradation of UC781, suggesting metal-catalyzed degradation of UC781. Furthermore, we observed substantial degradation of UC781 when stored in 1% Tween 80 and 1% DMSO solutions alone or in those with 10mM EDTA. On the other hand, improved stability of UC781 in the presence of 100 and 200mM of EDTA was observed in these solutions. The addition of both EDTA and citric acid in the stock solutions resulted in recovery of more than 60% of UC781 after 12 weeks. Generally, 10% SBE-beta-CD in the presence of EDTA and citric acid stabilized UC781 solutions: the amount of UC781 recovered approaching 95% after 12 weeks of storage at 40 degrees C. We also showed that the desulfuration reaction of the UC781 thioamide involves oxygen by running solution stability studies in deoxygenated media. Improved stability of UC781 in the present study indicates that the incorporation of EDTA, citric acid and SBE-beta-CD and the removal of oxygen in formulations of this drug will aid in increasing the stability of UC781 where solutions of the drug are required. Published by Elsevier B.V.

Results from the Heavy Ions In Space (HIIS) experiment on the ionic charge state of solar energetic particles

NASA Technical Reports Server (NTRS)

Tylka, Allan J.; Boberg, Paul R.; Adams, James H., Jr.; Beahm, Lorraine P.; Kleis, Thomas

1995-01-01

It has long been known that low-energy solar energetic particles (SEP's) are partially-ionized. For example, in large, so-called 'gradual' solar energetic particle events, at approximately 1 MeV/nucleon the measured mean ionic charge state, Q, of Fe ions is 14.1 +/- 0.2, corresponding to a plasma temperature of approximately 2 MK in the coronal or solar-wind source material. Recent studies, which have greatly clarified the origin of solar energetic particles and their relation to solar flares, suggest that ions in these SEP events are accelerated not at a flare site, but by shocks propagating through relatively low-density regions in the interplanetary medium. As a result, the partially-ionized states observed at low energies are expected to continue to higher energies. However, up to now there have been no high-energy measurements of ionic charge states to confirm this notion. We report here HIIS observations of Fe-group ions at 50-600 MeV/nucleon, at energies and fluences which cannot be explained by fully-ionized galactic cosmic rays, even in the presence of severe geomagnetic cutoff suppression. Above approximately 200 MeV/nucleon, all features of our data -- fluence, energy spectrum, elemental composition, and arrival directions -- can be explained by the large SEP events of October 1989, provided that the mean ionic charge state at these high energies is comparable to the measured value at approximately 1 MeV/nucleon. By comparing the HIIS observations with measurements in interplanetary space in October 1989, we determine the mean ionic charge state of SEP Fe ions at approximately 200-600 MeV/nucleon to be Q = 13.4 plus or minus 1.0, in good agreement with the observed value at approximately 1 MeV/nucleon. The source of the ions below approximately 200 MeV/nucleon is not yet clear. Partially-ionized ions are less effectively deflected by the Earth's magnetic field than fully-ionized cosmic rays and therefore have greatly enhanced access to low-Earth orbit

Battleship tank firing test of H-II launch vehicle - First stage

NASA Astrophysics Data System (ADS)

Watanabe, Atsutaro; Endo, Mamoru; Yamazaki, Isao; Maemura, Takashi; Namikawa, Tatsuo

1991-06-01

The H-II launch vehicle capable of placing 2-ton-class payloads on geostationary orbits is outlined, and focus is placed on its propulsion system. The development status of the project, including component development, preliminary battleship tank firing test (BFT-1), battleship tank firing test (BFT-2), and flight-type tank firing test (CFT) is discussed. The configuration and schematic diagram of BFT-2 are presented, and the firing test results of BFT-2 first series are analyzed, including engine performance, interface compatibility, and pressurization of subsystems.

Reduced risk of UC in families affected by appendicitis: a Danish national cohort study.

PubMed

Nyboe Andersen, Nynne; Gørtz, Sanne; Frisch, Morten; Jess, Tine

2017-08-01

The possible aetiological link between appendicitis and UC remains unclear. In order to investigate the hereditary component of the association, we studied the risk of UC in family members of individuals with appendicitis. A cohort of 7.1 million individuals was established by linkage of national registers in Denmark with data on kinship and diagnoses of appendicitis and UC. Poisson regression models were used to calculate first hospital contact rate ratios (RR) for UC with 95% CIs between individuals with or without relatives with a history of appendicitis. During 174 million person-years of follow-up between 1977 and 2011, a total of 190 004 cohort members developed appendicitis and 45 202 developed UC. Individuals having a first-degree relative with appendicitis before age 20 years had significantly reduced risk of UC (RR 0.90; 95% CI 0.86 to 0.95); this association was stronger in individuals with a family predisposition to UC (RR 0.66; 95% CI 0.51 to 0.83). Individuals with a first-degree relative diagnosed with appendicitis before age 20 years are at reduced risk of UC, particularly when there is a family predisposition to UC. Our findings question a previously hypothesised direct protective influence of appendicitis on inflammation of the large bowel. Rather, genetic or environmental factors linked to an increased risk of appendicitis while being protective against UC may explain the repeatedly reported reduced relative risk of UC in individuals with a history of appendicitis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

46 CFR 54.25-3 - Steel plates (modifies UCS-6).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Steel plates (modifies UCS-6). 54.25-3 Section 54.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-3 Steel plates (modifies UCS-6). The steels...

A brief history of the Bioengineering Institute of California and the UC System-wide Symposia.

PubMed

Chien, Shu

2011-04-01

The plan to establish a Multicampus Research Unit (MRU) on Bioengineering in the University of California (UC) System started in August 1999. The cooperative efforts of the UC campuses led to the formal establishment of the Bioengineering Institute of California (BIC) in October 2003. Three years prior to the BIC establishment, the System-wide Annual Bioengineering Symposium was started at UC Davis. The Symposia were then hosted sequentially by UC Santa Barbara, UC Berkeley, UCSD, UC Santa Cruz, UC Irvine, UCSF, UCLA, and UC Riverside, with the completion of the first cycle of a decade in the newest campus of UC Merced in 2009. The second cycle began in 2010 with the Symposium returning again to UC Davis. Each campus hosted a wonderful Symposium, with the active participation of students and faculty from all campuses, with the motto of "Ten campuses united as one, learning and growing together." These Symposia have contributed significantly to the collaborative research and training of students and young scientists in bioengineering, as well as fruitful interactions with industry and government agencies, which have provided strong support for these valuable meetings. The BIC will endeavor to further enhance these efforts by fostering research collaborations and joint education and training activities, with the ultimate goal of advancing bioengineering for the improvement of human health and wellbeing.

A Substellar Companion to Pleiades HII 3441

NASA Technical Reports Server (NTRS)

Konishi, Mihoko; Matsuo, Taro; Yamamoto, Kodai; Samland, Matthias; Sudo, Jun; Shibai, Hiroshi; Itoh, Yoichi; Fukagawa, Misato; Sumi, Takhiro; Kudo, Tomoyuki;

MS_RHII-RSD, a Dual-Function RNase HII-(p)ppGpp Synthetase from Mycobacterium smegmatis

PubMed Central

Murdeshwar, Maya S.

2012-01-01

In the noninfectious soil saprophyte Mycobacterium smegmatis, intracellular levels of the stress alarmones guanosine tetraphosphate and guanosine pentaphosphate, together termed (p)ppGpp, are regulated by the enzyme RelMsm. This enzyme consists of a single, bifunctional polypeptide chain that is capable of both synthesizing and hydrolyzing (p)ppGpp. The relMsm knockout strain of M. smegmatis (ΔrelMsm) is expected to show a (p)ppGpp null [(p)ppGpp0] phenotype. Contrary to this expectation, the strain is capable of synthesizing (p)ppGpp in vivo. In this study, we identify and functionally characterize the open reading frame (ORF), MSMEG_5849, that encodes a second functional (p)ppGpp synthetase in M. smegmatis. In addition to (p)ppGpp synthesis, the 567-amino-acid-long protein encoded by this gene is capable of hydrolyzing RNA·DNA hybrids and bears similarity to the conventional RNase HII enzymes. We have classified this protein as actRelMsm in accordance with the recent nomenclature proposed and have named it MS_RHII-RSD, indicating the two enzymatic activities present [RHII, RNase HII domain, originally identified as domain of unknown function 429 (DUF429), and RSD, RelA_SpoT nucleotidyl transferase domain, the SYNTH domain responsible for (p)ppGpp synthesis activity]. MS_RHII-RSD is expressed and is constitutively active in vivo and behaves like a monofunctional (p)ppGpp synthetase in vitro. The occurrence of the RNase HII and (p)ppGpp synthetase domains together on the same polypeptide chain is suggestive of an in vivo role for this novel protein as a link connecting the essential life processes of DNA replication, repair, and transcription to the highly conserved stress survival pathway, the stringent response. PMID:22636779

MS_RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis.

PubMed

Murdeshwar, Maya S; Chatterji, Dipankar

2012-08-01

In the noninfectious soil saprophyte Mycobacterium smegmatis, intracellular levels of the stress alarmones guanosine tetraphosphate and guanosine pentaphosphate, together termed (p)ppGpp, are regulated by the enzyme Rel(Msm). This enzyme consists of a single, bifunctional polypeptide chain that is capable of both synthesizing and hydrolyzing (p)ppGpp. The rel(Msm) knockout strain of M. smegmatis (Δrel(Msm)) is expected to show a (p)ppGpp null [(p)ppGpp(0)] phenotype. Contrary to this expectation, the strain is capable of synthesizing (p)ppGpp in vivo. In this study, we identify and functionally characterize the open reading frame (ORF), MSMEG_5849, that encodes a second functional (p)ppGpp synthetase in M. smegmatis. In addition to (p)ppGpp synthesis, the 567-amino-acid-long protein encoded by this gene is capable of hydrolyzing RNA·DNA hybrids and bears similarity to the conventional RNase HII enzymes. We have classified this protein as actRel(Msm) in accordance with the recent nomenclature proposed and have named it MS_RHII-RSD, indicating the two enzymatic activities present [RHII, RNase HII domain, originally identified as domain of unknown function 429 (DUF429), and RSD, RelA_SpoT nucleotidyl transferase domain, the SYNTH domain responsible for (p)ppGpp synthesis activity]. MS_RHII-RSD is expressed and is constitutively active in vivo and behaves like a monofunctional (p)ppGpp synthetase in vitro. The occurrence of the RNase HII and (p)ppGpp synthetase domains together on the same polypeptide chain is suggestive of an in vivo role for this novel protein as a link connecting the essential life processes of DNA replication, repair, and transcription to the highly conserved stress survival pathway, the stringent response.

46 CFR 54.25-10 - Low temperature operation-ferritic steels (replaces UCS-65 through UCS-67).

Code of Federal Regulations, 2013 CFR

2013-10-01

... the following additional requirements: Note: For high alloy steels refer to § 54.25-15. For heat... tempered steels. The ultimate and yield strengths shall be as shown in the applicable specification and... 46 Shipping 2 2013-10-01 2013-10-01 false Low temperature operation-ferritic steels (replaces UCS...

46 CFR 54.25-10 - Low temperature operation-ferritic steels (replaces UCS-65 through UCS-67).

Code of Federal Regulations, 2014 CFR

2014-10-01

... the following additional requirements: Note: For high alloy steels refer to § 54.25-15. For heat... tempered steels. The ultimate and yield strengths shall be as shown in the applicable specification and... 46 Shipping 2 2014-10-01 2014-10-01 false Low temperature operation-ferritic steels (replaces UCS...

46 CFR 54.25-10 - Low temperature operation-ferritic steels (replaces UCS-65 through UCS-67).

Code of Federal Regulations, 2012 CFR

2012-10-01

... the following additional requirements: Note: For high alloy steels refer to § 54.25-15. For heat... tempered steels. The ultimate and yield strengths shall be as shown in the applicable specification and... 46 Shipping 2 2012-10-01 2012-10-01 false Low temperature operation-ferritic steels (replaces UCS...

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.

PubMed

Cranenburg, Ellen C M; Brandenburg, Vincent M; Vermeer, Cees; Stenger, Melanie; Mühlenbruch, Georg; Mahnken, Andreas H; Gladziwa, Ulrich; Ketteler, Markus; Schurgers, Leon J

2009-02-01

Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a potent local inhibitor of cardiovascular calcification and accumulates at areas of calcification in its uncarboxylated form (ucMGP). We previously found significantly lower circulating ucMGP levels in patients with a high vascular calcification burden. Here we report on the potential of circulating ucMGP to serve as a biomarker for vascular calcification in haemodialysis (HD) patients. Circulating ucMGP levels were measured with an ELISA-based assay in 40 HD patients who underwent multi-slice computed tomography (MSCT) scanning to quantify the extent of coronary artery calcification (CAC). The mean ucMGP level in HD patients (193 +/- 65 nM) was significantly lower as compared to apparently healthy subjects of the same age (441 +/- 97 nM; p < 0.001) and patients with rheumatoid arthritis (RA) without CAC (560 +/- 140 nM; p < 0.001). Additionally, ucMGP levels correlated inversely with CAC scores (r = -0.41; p = 0.009), and this correlation persisted after adjustment for age, dialysis vintage and high-sensitivity C-reactive protein (hs-CRP). Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification.

Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans

PubMed Central

Schultz, Douglas H.; Balderston, Nicholas L.; Geiger, Jennifer A.; Helmstetter, Fred J.

2014-01-01

The nature of the relationship between explicit and implicit learning is a topic of considerable debate. In order to investigate this relationship we conducted two experiments on postconditioning revaluation of the unconditional stimulus (UCS) in human fear conditioning. In Experiment 1, the intensity of the UCS was decreased following acquisition for one group (devaluation) and held constant for another group (control). A subsequent test revealed that even though both groups exhibited similar levels of UCS expectancy, the devaluation group had significantly smaller conditional skin conductance responses. The devaluation effect was not explained by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS intensity had changed. In Experiment 2, the value of the UCS was increased following acquisition for one group (inflation) and held constant for another group (control). Test performance revealed that UCS inflation did not alter expectancy ratings, but the inflation group exhibited larger learned skin conductance responses than the control group. The inflation effect was not explained by differences in the explicit estimates of UCS probability or explicit knowledge that the UCS intensity had changed. The SCR revaluation effect was not dependent on explicit memory processes in either experiment. In both experiments we found differences on an implicit measure of learning in the absence of changes in explicit measures. Together, the differences observed between expectancy measures and skin conductance support the idea that these responses might reflect different types of memory formed during the same training procedure and be supported by separate neural systems. PMID:23731073

Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs.

PubMed

Deparle, L A; Gupta, R C; Canerdy, T D; Goad, J T; D'Altilio, M; Bagchi, M; Bagchi, D

2005-08-01

DeParle L. A., Gupta R. C., Canerdy T. D., Goad J. T., D'Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J. vet. Pharmacol. Therap.28, 385-390. In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs. Fifteen dogs in three groups received either no UC-II (Group I) or UC-II with 1 mg/day (Group II) or 10 mg/day (Group III) for 90 days. Lameness and pain were measured on a weekly basis for 120 days (90 days treatment plus 30 days post-treatment). Blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury). Dogs receiving 1 mg or 10 mg UC-II/day for 90 days showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion, with 10 mg showed greater improvement. At either dose of UC-II, no adverse effects were noted and no significant changes were noted in serum chemistry, suggesting that UC-II was well tolerated. In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following UC-II withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation. These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.

A Systematic Theoretical Study of UC6: Structure, Bonding Nature, and Spectroscopy.

PubMed

Du, Jiguang; Jiang, Gang

2017-11-20

The study of uranium carbides has received renewed attention in recent years due to the potential use of these compounds as fuels in new generations of nuclear reactors. The isomers of the UC 6 cluster were determined by DFT and ab initio methods. The structures obtained using SC-RECP for U were generally consistent with those obtained using an all-electron basis set (ZORA-SARC). The CCSD(T) calculations indicated that two isomers had similar energies and may coexist in laser evaporation experiments. The nature of the U-C bonds in the different isomers was examined via a topological analysis of the electron density, and the results indicated that the U-C bonds are predominantly closed-shell (ionic) interactions with a certain degree of covalent character in all cases, particularly in the linear species. The IR and UV-vis spectra of the isomers were theoretically simulated to provide information that can be used to identify the isomers of UC 6 in future experiments.

Quantification of process variables for carbothermic synthesis of UC1-xNx fuel microspheres

NASA Astrophysics Data System (ADS)

Lindemer, T. B.; Silva, C. M.; Henry, J. J.; McMurray, J. W.; Voit, S. L.; Collins, J. L.; Hunt, R. D.

2017-01-01

This report details the continued investigation of process variables involved in converting sol-gel-derived, urania-carbon microspheres to ∼820-μm-dia. UC1-xNx fuel kernels in flow-through, vertical Mo and W crucibles at temperatures up to 2123 K. Experiments included calcining of air-dried UO3-H2O-C microspheres in Ar and H2-containing gases, conversion of the resulting UO2-C kernels to dense UO2:2UC in the same gases and vacuum, and its conversion in N2 to UC1-xNx (x = ∼0.85). The thermodynamics of the relevant reactions were applied extensively to interpret and control the process variables. Producing the precursor UO2:2UC kernel of ∼96% theoretical density was required, but its subsequent conversion to UC1-xNx at 2123 K was not accompanied by sintering and resulted in ∼83-86% of theoretical density. Increasing the UC1-xNx kernel nitride component to ∼0.98 in flowing N2-H2 mixtures to evolve HCN was shown to be quantitatively consistent with present and past experiments and the only useful application of H2 in the entire process.

Lack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaques.

PubMed

McConville, Christopher; Smith, James M; McCoy, Clare F; Srinivasan, Priya; Mitchell, James; Holder, Angela; Otten, Ron A; Butera, Salvatore; Doncel, Gustavo F; Friend, David R; Malcolm, R Karl

2015-02-01

This study describes the preclinical development of a matrix-type silicone elastomer vaginal ring device designed to provide controlled release of UC781, a non-nucleoside reverse transcriptase inhibitor. Testing of both human- and macaque-sized rings in a sink condition in vitro release model demonstrated continuous UC781 release in quantities considered sufficient to maintain vaginal fluid concentrations at levels 82-860-fold higher than the in vitro IC50 (2.0 to 10.4 nM) and therefore potentially protect against mucosal transmission of HIV. The 100-mg UC781 rings were well tolerated in pig-tailed macaques, did not induce local inflammation as determined by cytokine analysis and maintained median concentrations in vaginal fluids of UC781 in the range of 0.27 to 5.18 mM during the course of the 28-day study. Analysis of residual UC781 content in rings after completion of both the in vitro release and macaque pharmacokinetic studies revealed that 57 and 5 mg of UC781 was released, respectively. The pharmacokinetic analysis of a 100-mg UC781 vaginal ring in pig-tailed macaques showed poor in vivo-in vitro correlation, attributed to the very poor solubility of UC781 in vaginal fluid and resulting in a dissolution-controlled drug release mechanism rather than the expected diffusion-controlled mechanism.

Umbilical cord mesenchymal stem cell (UC-MSC) transplantations for cerebral palsy

PubMed Central

Dong, Huajiang; Li, Gang; Shang, Chongzhi; Yin, Huijuan; Luo, Yuechen; Meng, Huipeng; Li, Xiaohong; Wang, Yali; Lin, Ling; Zhao, Mingliang

2018-01-01

This study reports a case of a 4-year-old boy patient with abnormalities of muscle tone, movement and motor skills, as well as unstable gait leading to frequent falls. The results of the electroencephalogram (EEG) indicate moderately abnormal EEG, accompanied by irregular seizures. Based on these clinical characteristics, the patient was diagnosed with cerebral palsy (CP) in our hospital. In this study, the patient was treated with umbilical cord mesenchymal stem cell (UC-MSC) transplantation therapy. This patient received UC-MSC transplantation 3 times (5.3*107) in total. After three successive cell transplantations, the patient recovered well and showed obvious improvements in EEG and limb strength, motor function, and language expression. However, the improvement in intelligence quotient (IQ) was less obvious. These results indicate that UC-MSC transplantation is a promising treatment for cerebral palsy. PMID:29636880

UC Merced Center for Computational Biology Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colvin, Michael; Watanabe, Masakatsu

Final report for the UC Merced Center for Computational Biology. The Center for Computational Biology (CCB) was established to support multidisciplinary scientific research and academic programs in computational biology at the new University of California campus in Merced. In 2003, the growing gap between biology research and education was documented in a report from the National Academy of Sciences, Bio2010 Transforming Undergraduate Education for Future Research Biologists. We believed that a new type of biological sciences undergraduate and graduate programs that emphasized biological concepts and considered biology as an information science would have a dramatic impact in enabling the transformationmore » of biology. UC Merced as newest UC campus and the first new U.S. research university of the 21st century was ideally suited to adopt an alternate strategy - to create a new Biological Sciences majors and graduate group that incorporated the strong computational and mathematical vision articulated in the Bio2010 report. CCB aimed to leverage this strong commitment at UC Merced to develop a new educational program based on the principle of biology as a quantitative, model-driven science. Also we expected that the center would be enable the dissemination of computational biology course materials to other university and feeder institutions, and foster research projects that exemplify a mathematical and computations-based approach to the life sciences. As this report describes, the CCB has been successful in achieving these goals, and multidisciplinary computational biology is now an integral part of UC Merced undergraduate, graduate and research programs in the life sciences. The CCB began in fall 2004 with the aid of an award from U.S. Department of Energy (DOE), under its Genomes to Life program of support for the development of research and educational infrastructure in the modern biological sciences. This report to DOE describes the research and academic

VLBI observations of 6 GHz OH masers in three ultra-compact H Ii regions

NASA Astrophysics Data System (ADS)

Desmurs, J. F.; Baudry, A.

1998-12-01

Following our successful analysis of VLBI observations of the (2) Pi_ {3/ 2}, J={5/ 2}, F=3-3 and F=2-2 excited OH emission at 6035 and 6031 MHz in W3(OH), we have analyzed the same transitions in three other ultra-compact HII regions, M17, ON1, and W51. The restoring beams were in the range 6 to 30 milliarc sec. The F=3-3 and 2-2 hyperfine transitions of OH were both mapped in ON1. Seven 6035 MHz LCP or RCP maser components were identified in ON1. They are distributed over a region whose diameter is similar to that of the compact HII region, namely ~ 0.4 - 0.5 arc sec. In contrast with the F=3-3 line emission, the F=2-2 transition at 6031 MHz is nearly an order of magnitude weaker than the peak 6035 MHz emission. In M17, we observed fringes only in the 6035 MHz line. The detected OH components appear to be projected on to the compact HII region. We report also on weak VLBI detection of the 6035 MHz emission from W51. This emission seems to be located between two active ultra-compact HII regions in a complex area which deserves further investigation. The 5 cm OH minimum brightness temperatures range from about 3 10(7) K in W51 to 8 10(9) K in ON1. Variability of the 6035 or 6031 MHz emission is well established and suggests that the 5 cm OH masers are not fully saturated. The high spectral and spatial resolutions achieved in this work allowed us to identify Zeeman pairs and hence to derive the magnetic field strength. In ON1 and W51 the field lies in the range 4 to 6 mG with a trend for higher field at 6031 MHz than at 6035 MHz in ON1. In M17 no Zeeman splitting was observed and the magnetic field appears to be weaker than 1 mG.

The Hydrodynamical Models of the Cometary Compact HII Region

NASA Astrophysics Data System (ADS)

Zhu, Feng-Yao; Zhu, Qing-Feng; Li, Juan; Zhang, Jiang-Shui; Wang, Jun-Zhi

2015-10-01

We have developed a full numerical method to study the gas dynamics of cometary ultracompact H ii regions, and associated photodissociation regions (PDRs). The bow-shock and champagne-flow models with a 40.9/21.9 M⊙ star are simulated. In the bow-shock models, the massive star is assumed to move through dense (n = 8000 cm-3) molecular material with a stellar velocity of 15 km s-1. In the champagne-flow models, an exponential distribution of density with a scale height of 0.2 pc is assumed. The profiles of the [Ne ii] 12.81 μm and H2 S(2) lines from the ionized regions and PDRs are compared for two sets of models. In champagne-flow models, emission lines from the ionized gas clearly show the effect of acceleration along the direction toward the tail due to the density gradient. The kinematics of the molecular gas inside the dense shell are mainly due to the expansion of the H ii region. However, in bow-shock models the ionized gas mainly moves in the same direction as the stellar motion. The kinematics of the molecular gas inside the dense shell simply reflects the motion of the dense shell with respect to the star. These differences can be used to distinguish two sets of models.

A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking.

PubMed

Luo, Yi-xiao; Xue, Yan-xue; Liu, Jian-feng; Shi, Hai-shui; Jian, Min; Han, Ying; Zhu, Wei-li; Bao, Yan-ping; Wu, Ping; Ding, Zeng-bo; Shen, Hao-wei; Shi, Jie; Shaham, Yavin; Lu, Lin

2015-07-14

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.

A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking

PubMed Central

Luo, Yi-xiao; Xue, Yan-xue; Liu, Jian-feng; Shi, Hai-shui; Jian, Min; Han, Ying; Zhu, Wei-li; Bao, Yan-ping; Wu, Ping; Ding, Zeng-bo; Shen, Hao-wei; Shi, Jie; Shaham, Yavin; Lu, Lin

2015-01-01

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts. PMID:26169171

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Requirement for postweld heat treatment (modifies UCS-56... for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon... the storage or transportation of liquefied compressed gases shall be postweld heat treated regardless...

Thermodynamic and experimental study of UC powders ignition

NASA Astrophysics Data System (ADS)

Le Guyadec, F.; Rado, C.; Joffre, S.; Coullomb, S.; Chatillon, C.; Blanquet, E.

2009-09-01

Mixed plutonium and uranium carbide (UPuC) is considered as a possible fuel material for future nuclear reactors. However, UPuC is pyrophoric and fine powders of UPuC are subject to temperature increase due to oxidation with air and possible ignition during conditioning and handling. In a first approach and to allow easier experimental conditions, this study was undertaken on uranium monocarbide (UC) with the aim to determine safe handling conditions for the production and reprocessing of uranium carbide fuels. The reactivity of uranium monocarbide in oxidizing atmosphere was studied in order to analyze the ignition process. Experimental thermogravimetric analysis (TGA) and differential thermal analysis (DTA) revealed that UC powder obtained by arc melting and milling is highly reactive in air at about 200 °C. The phases formed at the various observed stages of the oxidation process were analyzed by X-ray diffraction. At the same time, ignition was analyzed thermodynamically along isothermal sections of the U-C-O ternary diagram and the pressure of the gas produced by the UC + O 2 reaction was calculated. Two possible oxidation schemes were identified on the U-C-O phase diagram and assumptions are proposed concerning the overall oxidation and ignition paths. It is particularly important to understand the mechanisms involved since temperatures as high as 2500 °C could be reached, leading to CO(g) production and possibly to a blast effect.

Experimental study of UC polycrystals in the prospect of improving the as-fabricated sample purity

NASA Astrophysics Data System (ADS)

Raveu, Gaëlle; Martin, Guillaume; Fiquet, Olivier; Garcia, Philippe; Carlot, Gaëlle; Palancher, Hervé; Bonnin, Anne; Khodja, Hicham; Raepsaet, Caroline; Sauvage, Thierry; Barthe, Marie-France

2014-12-01

Uranium and plutonium carbides are candidate fuels for Generation IV nuclear reactors. This study is focused on the characterization of uranium monocarbide samples. The successive fabrication steps were carried out under atmospheres containing low oxygen and moisture concentrations (typically less than 100 ppm) but sample transfers occurred in air. Six samples were sliced from four pellets elaborated by carbothermic reaction under vacuum. Little presence of UC2 is expected in these samples. The α-UC2 phase was indeed detected within one of these UC samples during an XRD experiment performed with synchrotron radiation. Moreover, oxygen content at the surface of these samples was depth profiled using a recently developed nuclear reaction analysis method. Large oxygen concentrations were measured in the first micron below the sample surface and particularly in the first 100-150 nm. UC2 inclusions were found to be more oxidized than the surrounding matrix. This work points out to the fact that more care must be given at each step of UC fabrication since the material readily reacts with oxygen and moisture. A new glovebox facility using a highly purified atmosphere is currently being built in order to obtain single phase UC samples of better purity.

Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis.

PubMed

Parian, Alyssa; Limketkai, Berkeley; Koh, Joyce; Brant, Steven R; Bitton, Alain; Cho, Judy H; Duerr, Richard H; McGovern, Dermot P; Proctor, Deborah D; Regueiro, Miguel D; Rioux, John D; Schumm, Phil; Taylor, Kent D; Silverberg, Mark S; Steinhart, A Hillary; Hernaez, Ruben; Lazarev, Mark

2017-08-01

Early appendectomy is inversely associated with the development of UC. However, the impact of appendectomy on the clinical course of UC is controversial, generally favouring a milder disease course. We aim to describe the effect appendectomy has on the disease course of UC with focus on the timing of appendectomy in relation to UC diagnosis. Using the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium database of patients with UC, the risk of colectomy was compared between patients who did and did not undergo appendectomy. In addition, we performed a meta-analysis of studies that examined the association between appendectomy and colectomy. 2980 patients with UC were initially included. 111 (4.4%) patients with UC had an appendectomy; of which 63 were performed prior to UC diagnosis and 48 after diagnosis. In multivariable analysis, appendectomy performed at any time was an independent risk factor for colectomy (OR 1.9, 95% CI 1.1 to 3.1), with appendectomy performed after UC diagnosis most strongly associated with colectomy (OR 2.2, 95% CI 1.1 to 4.5). An updated meta-analysis showed appendectomy performed either prior to or after UC diagnosis had no effect on colectomy rates. Appendectomy performed at any time in relation to UC diagnosis was not associated with a decrease in severity of disease. In fact, appendectomy after UC diagnosis may be associated with a higher risk of colectomy. These findings question the proposed use of appendectomy as treatment for UC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

46 CFR 54.25-7 - Requirement for postweld heat treatment (modifies UCS-56).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Requirement for postweld heat treatment (modifies UCS-56... ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-7 Requirement for postweld heat treatment (modifies UCS-56). (a) Postweld heat treatment is required for all carbon...

UCS-PROMOVE: The Engineer of the Future

ERIC Educational Resources Information Center

Villas-Boas, V.

2010-01-01

The Universidade de Caxias do Sul (UCS) elaborated the cooperative project called "The engineer of the future", with the objective of promoting science and engineering among high school teachers and students. This project aims to improve the quality of the teaching and to increase the interest of students in technological areas, leading…

Oxidation of UC: An in situ high temperature environmental scanning electron microscopy study

NASA Astrophysics Data System (ADS)

Gasparrini, Claudia; Podor, Renaud; Horlait, Denis; Rushton, Michael J. D.; Fiquet, Olivier; Lee, William Edward

2017-10-01

In situ HT-ESEM oxidation of sintered UC fragments revealed the morphological changes occurring during the transformation between UC to UO2 and UO2 to U3O8 at 723-848 K and in an atmosphere of 10-100 Pa O2. Two main oxidation pathways were revealed. Oxidation at 723 K in atmospheres ≤25 Pa O2 showed the transformation from UC to UO2+x, as confirmed by post mortem HRTEM analysis. This oxidation pathway was comprised of three steps: (i) an induction period, where only surface UC particles oxidised, (ii) a sample area expansion accompanied by crack formation and propagation, (iii) a stabilisation of the total crack length inferring that crack propagation had stopped. Samples oxidised under 50 Pa O2 at 723 K and at 773-848 K for 10-100 Pa O2 showed an "explosive" oxidation pathway: (i) sample area expansion occurred as soon as oxygen was inserted into the chamber and crack propagation and crack length followed an exponential law; (ii) cracks propagated as a network and the oxide layer fragmented, (iii) an "explosion" occurred causing a popcorn-like transformation, typical for oxidation from UO2 to U3O8. HRTEM characterisation revealed U3O8 preferentially grow in the [001] direction. The explosive growth, triggered by ignition of UC, proceeded as a self-propagating high-temperature synthesis reaction, with a propagation speed of 150-500 ± 50 μm/s.

Massive Molecular Outflows Toward Methanol Masers: by Eye and Machine Learning

NASA Astrophysics Data System (ADS)

de Villiers, Helena

2013-07-01

The best known evolutionary state of massive stars is that of the UC HII region, occurring a few 10^5 years after the initial formation of a massive YSO. Currently objects in the "hot core" phase, occurring prior to the UC HII region, are studied with great interest. Because the YSO is still supposed to be accreting at this stage, one would expect outflows from the central object to develop during this phase, entraining surrounding cold molecular gas in their wake. During this time, 6.7 GHz (Class II) methanol masers will also turn on. They are uniquely associated with massive YSO's, thus serve as a useful signpost. We searched for molecular outflows with the JCMT and HARP focal plane array in a sample of targets toward 6.7 GHz methanol maser coordinates within 20 < Glon < 34. We found 58 CO clumps but only 47 of them were closely associated with the methanol masers. Their spectra were analyzed for broadened line wings, which were found to be present in 46 of the spectra, indicating either bi- or mono-polar outflows. This is a 98% detection frequency. The velocity ranges of these spectrum wings were used to create two dimensional blue and red maps. The out flows' physical parameters were calculated and compared with literature. We created a catalog of kinematic distances and properties of all the 13CO outflows associated with Class II methanol masers, as well as their associated H_2 core and virial masses as derived from the C18O data. In the the light of our results we emphasize the need for an automated detection process, especially with the increasing number of wide-area surveys. We are currently exploring the use of machine learning algorithms (specifically Support Vector Machines) in the detection of high velocity structures in p-p-v cubes.

Spiral arms and massive star formation: Analysis of the CO face-on pictures of the galaxy

NASA Technical Reports Server (NTRS)

Clemens, D. P.; Sanders, D. B.; Scoville, N. Z.

1986-01-01

The face-on distribution of molecular gas in the first Galactic quadrant, derived from the Massachusetts-Stony Brook Galactic Plane CO Survey, was compared to the Galactic distribution of giant radio HII regions. The HII regions were found to preferentially select gas regions of higher than average density (more than twice the mean) and showed a strong correlation with the second power of the gas density. Systematic effects were tested with a Monte Carlo simulated HII region distribution and found to be negligible. The 135 HII regions were selected from the radio catalogs of Downes et at. (1980) and Wink et al. (1982). The HII regions were required to be within the CO survey 1 and b limits, within the solar circle, and not part of the 3 kpc expanding arm. The velocities of the HII regions were tabulated by the catalog authors and obvious associations with known objects and H2CO absorptions were used by them to assign distances. The distance assignments were here grouped into two categories; (1) those HII regions with definite distance assignments (85 objects); and (2) those HII regions with less secure distance assignments and those for which no near-far assignment was possible (50 objects).

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease.

PubMed

Wang, Xinxin; Ma, Shanshan; Yang, Bo; Huang, Tuanjie; Meng, Nan; Xu, Ling; Xing, Qu; Zhang, Yanting; Zhang, Kun; Li, Qinghua; Zhang, Tao; Wu, Junwei; Yang, Greta Luyuan; Guan, Fangxia; Wang, Jian

2018-02-26

Mesenchymal stem cell transplantation is a promising therapeutic approach for Alzheimer's disease (AD). However, poor engraftment and limited survival rates are major obstacles for its clinical application. Resveratrol, an activator of silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is beneficial for neurodegenerative disorders. The present study is designed to explore whether resveratrol regulates the fate of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol would be efficacious in the treatment of neurodegeneration in a mouse model of AD through SIRT1 signaling. Herein, we report that resveratrol facilitates hUC-MSCs engraftment in the hippocampus of AD mice and resveratrol enhances the therapeutic effects of hUC-MSCs in this model as demonstrated by improved learning and memory in the Morris water maze, enhanced neurogenesis and alleviated neural apoptosis in the hippocampus of the AD mice. Moreover, hUC-MSCs and resveratrol jointly regulate expression of hippocampal SIRT1, PCNA, p53, ac-p53, p21, and p16. These data strongly suggests that hUC-MSCs transplantation combined with resveratrol may be an effective therapy for AD. Copyright © 2017. Published by Elsevier B.V.

An atlas of H-alpha-emitting regions in M33: A systematic search for SS433 star candidates

NASA Technical Reports Server (NTRS)

Calzetti, Daniela; Kinney, Anne L.; Ford, Holland; Doggett, Jesse; Long, Knox S.

1995-01-01

We report finding charts and accurate positions for 432 compact H-alpha emitting regions in the Local Group galaxy M 33 (NGC 598), in an effort to isolate candidates for an SS433-like stellar system. The objects were extracted from narrow band images, centered in the rest-frame H-alpha (lambda 6563 A) and in the red continuum at 6100 A. The atlas is complete down to V approximately equal to 20 and includes 279 compact HII regions and 153 line emitting point-like sources. The point-like sources undoubtedly include a variety of objects: very small HII regions, early type stars with intense stellar winds, and Wolf-Rayet stars, but should also contain objects with the characteristics of SS433. This extensive survey of compact H-alpha regions in M 33 is a first step towards the identification of peculiar stellar systems like SS433 in external galaxies.

Quantification of process variables for carbothermic synthesis of UC 1-xN x fuel microspheres

DOE PAGES

Lindemer, Terrance B.; Silva, Chinthaka M.; Henry, Jr, John James; ...

2016-11-05

This report details the continued investigation of process variables involved in converting sol-gel-derived, urania-carbon microspheres to ~820-μm-dia. UC 1-xN x fuel kernels in flow-through, vertical Mo and W crucibles at temperatures up to 2123 K. Experiments included calcining of air-dried UO 3-H 2O-C microspheres in Ar and H 2-containing gases, conversion of the resulting UO 2-C kernels to dense UO2:2UC in the same gases and vacuum, and its conversion in N 2 to UC 1-xN x (x = ~0.85). The thermodynamics of the relevant reactions were applied extensively to interpret and control the process variables. Producing the precursor UO 2:2UCmore » kernel of ~96% theoretical density was required, but its subsequent conversion to UC 1-xN x at 2123 K was not accompanied by sintering and resulted in ~83-86% of theoretical density. Increasing the UC 1-xN x kernel nitride component to ~0.98 in flowing N 2-H 2 mixtures to evolve HCN was shown to be quantitatively consistent with present and past experiments and the only useful application of H 2 in the entire process.« less

Hubble Space Telescope Hx Imaging of Star-forming Galaxies at z approximately equal to 1-1.5: Evolution in the Size and Luminosity of Giant H II Regions

NASA Technical Reports Server (NTRS)

Livermore, R. C.; Jones, T.; Richard, J.; Bower, R. G.; Ellis, R. S.; Swinbank, A. M.; Rigby, J. R.; Smail, Ian; Arribas, S.; Rodriguez-Zaurin, J.;

Quantitative spectroscopy of Wolf-Rayet stars in HD97950 and R136a - the cores of giant HII regions

NASA Astrophysics Data System (ADS)

Crowther, P. A.; Dessart, Luc

1998-05-01

We present quantitative analyses of Wolf-Rayet stars in the cores of two giant Hii regions - HD97950 in NGC3603 and R136a in 30 Doradus - based on archive Hubble Space Telescope (HST) spectroscopy. We confirm previous WN6h+abs classifications for components A1, B and C in HD97950, while classifications for R136a1-3 are revised from O3If^*/WN6 to WN5h. From detailed non-local thermodynamic equilibrium analyses, we find that all Wolf-Rayet stars exhibit products of CNO-processed material at their surface since they are rich in both helium (H/He~3-6, by number) and nitrogen (N/He~0.002-0.006). Their luminosities, log(L/Lsolar)=6.0-6.3, are amongst the highest known for Wolf-Rayet stars. Consequently they are very massive stars (M_init>=100Msolar) at a relatively low age (~2Myr), reminiscent of the late WN stars in the Carina Nebula. We obtain a revised distance modulus of 15.03mag (=10.1kpc) to NGC3603 based on available photometry, an updated M_v calibration for early O stars and a reddening of E(B-V)=1.23mag towards its core. From a census of the massive stellar content of the two central clusters we conclude that their global properties are comparable. We evaluate the contribution made by Wolf-Rayet stars to the total Lyman continuum ionizing flux and kinetic energy released into the ISM. We discuss how simple calibrations can be used to estimate stellar luminosities, ionizing fluxes and mass-loss rates of luminous OB stars. Wolf-Rayet stars provide ~20 per cent of the total ionizing flux (~1.3x10^51 Ly photons^-1) within 0.5pc of their cores, and ~60 per cent of the total kinetic energy injected into the ISM (5-6x10^38ergs^-1), despite representing only 10 per cent of the massive stellar population. For the larger R136 cluster in 30 Doradus (r<=10pc), 117 massive stars provide a total ionizing flux of 4x10^51 Ly photons^-1 and release a total kinetic energy of 1.6x10^39 ergs^-1 into the ISM, the latter being dominated by nine WR (43 per cent) and six O3If^*/WN (29

Physician Perspectives on Unresolved Issues in the Management of Ulcerative Colitis: The UC Horizons Project.

PubMed

Gisbert, Javier P; Barreiro-de Acosta, Manuel; Esteve, María; García-Sánchez, Valle; Gomollón, Fernando; Guardiola, Jordi; Hinojosa, Joaquin; Martín Arranz, Maria-Dolores; Minguez, Miguel; Taxonera, Carlos; Vera, Isabel

2016-03-01

There is still uncertainty about what constitutes the best therapeutic practice in ulcerative colitis (UC). The purpose of the "UC Horizons Project" was to raise a series of questions regarding the management of UC to provide responses based on the best scientific evidence available. The 11 members of the scientific committee prepared draft answers to the 10 questions from available evidence after a literature search. A total of 48 Spanish gastroenterology specialists nationwide participated in the project. The national meeting discussed the 10 issues in working groups and reached consensus regarding the recommendations by anonymous, interactive vote following the Delphi methodology. Final answers were developed, based on evidence and clinical experience of the participants. All the recommendations achieved a high level of agreement in the plenary vote, although the quality of the evidence was markedly heterogeneous. The lowest percentage of agreement corresponded to the questions with the weakest level of evidence, highlighting the necessity of conducting further studies in these areas. The recommendations focused on (1) aminosalicylates therapy (regarding dose and appropriateness of coadministration with thiopurines), (2) corticosteroid therapy (regarding dose and route of administration), (3) thiopurine treatment (regarding indications and possibility of withdrawal), (4) anti-tumor necrosis factor therapy (regarding appropriateness of combination with thiopurines, intensification, or discontinuation of treatment), and (5) colorectal cancer (regarding risk and time trends). The UC Horizons Project raised a series of eminently practical questions about the management of UC and provided responses based on the best scientific evidence available.

MF2KtoMF05UC, a Program To Convert MODFLOW-2000 Files to MODFLOW-2005 and UCODE_2005 Files

USGS Publications Warehouse

Harbaugh, Arlen W.

2007-01-01

The program MF2KtoMF05UC has been developed to convert MODFLOW-2000 input files for use by MODFLOW-2005 and UCODE_2005. MF2KtoMF05UC was written in the Fortran 90 computer language. This report documents the use of MF2KtoMF05UC.

H-II launch vehicle telemetry system realizing intelligent control of pre-processed data from remote terminal

NASA Astrophysics Data System (ADS)

Tanioka, Noritaka; Yoshida, Yasunori; Obi, Shinzo; Chiba, Ryoichi; Nakai, Kazumoto

The development of a PCM telemetry system for the Japanese H-II launch vehicle is discussed. PCM data streams acquire and process data from remote terminals which can be located at any place near the data source. The data are synchronized by a clock and are individually controlled by a central PCM data processing unit. The system allows the launch vehicle to acquire data from many different areas of the rocket, with a total of 879 channels. The data are multiplexed and processed into one PCM data stream and are down-linked on a phase-modulated RF carrier.

Environmental Profiles of Paper vs. Electronic UC-CEAS Annual Reports

EPA Science Inventory

In 2010, the University of Cincinnati College of Engineering and Applied Sciences (UC-CEAS) created a new electronic format for the Annual Report that could be distributed through the college’s website to replace the prior print version. In order to determine the environmental co...

Disk Evaporation in Star Forming Regions

NASA Technical Reports Server (NTRS)

Hollenbach, David; DeVincenzi, Donald L. (Technical Monitor)

2000-01-01

Young stars produce sufficient ultraviolet photon luminosity and mechanical luminosity in their winds to significantly affect the structure and evolution of the accretion disks surrounding them. The Lyman continuum photons create a nearly static, ionized, isothermal 10(exp 4) K atmosphere forms above the neutral disk at small distances from the star. Further out, they create a photoevaporative flow which relatively rapidly destroys the disk. The resulting slow (10-50 km/s) ionized outflow, which persists for approx. greater than 10(exp 5) years for disk masses M(sub d) approx. 0.3M(sub *), may explain the observational characteristics of many ultracompact HII regions. We compare model results to the observed radio free-free spectra and luminosities of ultracompact HII regions and to the interesting source MWC349, which is observed to produce hydrogen masers. We apply the results to Ae and Be stars in order to determine the lifetimes of disks around such stars. We also apply the results to the early solar nebula to explain the the dispersal of the solar nebula and the differences in hydrogen content in the giant planets. Finally, we model the small bright objects ("proplyds") observed in the Orion Nebula as disks around young, low mass stars which are externally illuminated by the UV photons from the nearby massive star Theta(sup 1) C.

Star formation in the inner galaxy: A far-infrared and radio study of two H2 regions

NASA Technical Reports Server (NTRS)

Lester, D. F.; Dinerstein, H. L.; Werner, M. W.; Harvey, P. M.; Evans, N. J.; Brown, R. L.

1985-01-01

Far-infrared and radio continuum maps have been made of the central 6' of the inner-galaxy HII regions G30.8-0.0 (in the W43 complex) and G25.4-0.2, along with radio and molecular line measurements at selected positions. The purpose of this study is an effort to understand star formation in the molecular ring at 5 kpc in galactic radius. Measurements at several far infrared wavelengths allow the dust temperature structures and total far infrared fluxes to be determined. Comparison of the radio and infrared maps shows a close relationship between the ionized gas and the infrared-emitting material. There is evidence that parts of G30.8 are substantially affected by extinction, even at far-infrared wavelengths. Using radio recombination line and CO line data for G25.4-0.2, the distance ambiguity for this source is resolved. The large distance previously ascribed to the entire complex is found to apply to only one of the two main components. The confusion in distance determination is found to result from an extraordinary near-superposition of two bright HII regions. Using the revised distances of 4.3 kpc for G25.4SE and 12 kpc for G25.4NW, it is found that the latter, which is apparently the fainter of the two sources, is actually the more luminous. The ratio of total luminosity to ionizing luminosity is very similar to that of HII regions in the solar circle. Assuming a coeval population of ionizing stars, a normal initial mass function is indicated.

Spotted star light curve numerical modeling technique and its application to HII 1883 surface imaging

NASA Astrophysics Data System (ADS)

Kolbin, A. I.; Shimansky, V. V.

2014-04-01

We developed a code for imaging the surfaces of spotted stars by a set of circular spots with a uniform temperature distribution. The flux from the spotted surface is computed by partitioning the spots into elementary areas. The code takes into account the passing of spots behind the visible stellar limb, limb darkening, and overlapping of spots. Modeling of light curves includes the use of recent results of the theory of stellar atmospheres needed to take into account the temperature dependence of flux intensity and limb darkening coefficients. The search for spot parameters is based on the analysis of several light curves obtained in different photometric bands. We test our technique by applying it to HII 1883.

Space Station UCS antenna pattern computation and measurement. [UHF Communication Subsystem

NASA Technical Reports Server (NTRS)

Hwu, Shian U.; Lu, Ba P.; Johnson, Larry A.; Fournet, Jon S.; Panneton, Robert J.; Ngo, John D.; Eggers, Donald S.; Arndt, G. D.

1993-01-01

The purpose of this paper is to analyze the interference to the Space Station Ultrahigh Frequency (UHF) Communication Subsystem (UCS) antenna radiation pattern due to its environment - Space Station. A hybrid Computational Electromagnetics (CEM) technique was applied in this study. The antenna was modeled using the Method of Moments (MOM) and the radiation patterns were computed using the Uniform Geometrical Theory of Diffraction (GTD) in which the effects of the reflected and diffracted fields from surfaces, edges, and vertices of the Space Station structures were included. In order to validate the CEM techniques, and to provide confidence in the computer-generated results, a comparison with experimental measurements was made for a 1/15 scale Space Station mockup. Based on the results accomplished, good agreement on experimental and computed results was obtained. The computed results using the CEM techniques for the Space Station UCS antenna pattern predictions have been validated.

Corresponding color datasets and a chromatic adaptation model based on the OSA-UCS system.

PubMed

Oleari, Claudio

2014-07-01

Today chromatic adaptation transforms (CATs) are reconsidered, since their mathematical inconsistency has been shown in Color Res. Appl.38, 188 (2013) and by the CIE technical committee TC 8-11: CIECAM02 Mathematics. In 2004-2005 the author proposed an adaptation transform based on the uniform color scale system of the Optical Society of America (OSA-UCS) [J. Opt. Soc. Am. A21, 677 (2004); Color Res. Appl. 30, 31 (2005)] that transforms the cone-activation stimuli into adapted stimuli. The present work considers all the 37 available corresponding color (CC) datasets selected by CIE and (1) shows that the adapted stimuli obtained from CC data are defined up to an unknown transformation, and an unambiguous definition of the adapted stimuli requires additional hypotheses or suitable experimental data (as it is in the OSA-UCS system); (2) produces a CAT, represented by a linear transformation between CCs, associated with any CC dataset, whose high quality measured in ΔE units discards the possibility of nonlinear transformations; (3) analyzes these color-conversion matrices in a heuristic way with a reference adaptation that is approximately that of the OSA-UCS adapted colors for the D65 illuminant and particularly shows accordance with the Hunt effect and the Bezold-Brücke hue shift; (4) proposes the measurements of CC stimuli with a reference adaptation equal to that of the visual situation of the OSA-UCS system for defining adapted colors for any considered illumination adaptation and therefore for defining a general CAT formula.

Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

PubMed Central

2013-01-01

Background UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis. The purpose of this study was to assess the efficacy and tolerability of UC-II in moderating joint function and joint pain due to strenuous exercise in healthy subjects. Methods This randomized, double-blind, placebo-controlled study was conducted in healthy subjects who had no prior history of arthritic disease or joint pain at rest but experienced joint discomfort with physical activity. Fifty-five subjects who reported knee pain after participating in a standardized stepmill performance test were randomized to receive placebo (n = 28) or the UC-II (40 mg daily, n = 27) product for 120 days. Joint function was assessed by changes in degree of knee flexion and knee extension as well as measuring the time to experiencing and recovering from joint pain following strenuous stepmill exertion. Results After 120 days of supplementation, subjects in the UC-II group exhibited a statistically significant improvement in average knee extension compared to placebo (81.0 ± 1.3º vs 74.0 ± 2.2º; p = 0.011) and to baseline (81.0 ± 1.3º vs 73.2 ± 1.9º; p = 0.002). The UC-II cohort also demonstrated a statistically significant change in average knee extension at day 90 (78.8 ± 1.9º vs 73.2 ± 1.9º; p = 0.045) versus baseline. No significant change in knee extension was observed in the placebo group at any time. It was also noted that the UC-II group exercised longer before experiencing any initial joint discomfort at day 120 (2.8 ± 0.5 min, p = 0.019), compared to baseline (1.4 ± 0.2 min). By contrast, no significant changes were seen in the placebo group. No product related adverse events were observed during the study. At study conclusion, five

Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers.

PubMed

Lugo, James P; Saiyed, Zainulabedin M; Lau, Francis C; Molina, Jhanna Pamela L; Pakdaman, Michael N; Shamie, Arya Nick; Udani, Jay K

2013-10-24

UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis. The purpose of this study was to assess the efficacy and tolerability of UC-II in moderating joint function and joint pain due to strenuous exercise in healthy subjects. This randomized, double-blind, placebo-controlled study was conducted in healthy subjects who had no prior history of arthritic disease or joint pain at rest but experienced joint discomfort with physical activity. Fifty-five subjects who reported knee pain after participating in a standardized stepmill performance test were randomized to receive placebo (n = 28) or the UC-II (40 mg daily, n = 27) product for 120 days. Joint function was assessed by changes in degree of knee flexion and knee extension as well as measuring the time to experiencing and recovering from joint pain following strenuous stepmill exertion. After 120 days of supplementation, subjects in the UC-II group exhibited a statistically significant improvement in average knee extension compared to placebo (81.0 ± 1.3º vs 74.0 ± 2.2º; p = 0.011) and to baseline (81.0 ± 1.3º vs 73.2 ± 1.9º; p = 0.002). The UC-II cohort also demonstrated a statistically significant change in average knee extension at day 90 (78.8 ± 1.9º vs 73.2 ± 1.9º; p = 0.045) versus baseline. No significant change in knee extension was observed in the placebo group at any time. It was also noted that the UC-II group exercised longer before experiencing any initial joint discomfort at day 120 (2.8 ± 0.5 min, p = 0.019), compared to baseline (1.4 ± 0.2 min). By contrast, no significant changes were seen in the placebo group. No product related adverse events were observed during the study. At study conclusion, five individuals in the UC-II cohort

20 CFR 603.23 - What information must State UC agencies obtain from other agencies, and crossmatch with wage...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What information must State UC agencies obtain from other agencies, and crossmatch with wage information, for purposes of an IEVS? 603.23 Section 603.23 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL-STATE UNEMPLOYMENT COMPENSATION (UC) PROGRAM;...

Role of oral nitrate in the nitrosation of ( UC)proline by conventional microflora and germ-free rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mallett, A.K.; Rowland, I.R.; Walters, D.G.

1985-11-01

The urinary excretion of N-nitroso-L-(U- UC)proline by conventional microflora and germ free rats was used to assess the role of the gut bacteria and oral nitrate in the endogenous formation of N-nitroso compounds. The formation of nitrosoproline was qualitatively similar in conventional and germfree rats suggesting no involvement of the intestinal flora in this reaction. Furthermore, nitrosamino acid production was similar following the administration of nitrate and (U- UC)proline or (U- UC)proline alone, demonstrating no involvement of exogenous nitrate under the conditions of the experiment. Dietary contamination with nitrate/nitrite was negligible. The results are consistent with the suggestion that nitrate/nitritemore » reserves in the body are important in the formation of nitrosoproline in vivo.« less

UNIVERSITY OF CALIFORNIA – CENTER FOR ENVIRONMENTAL IMPLICATIONS OF NANOTECHNOLOGY (UC-CEIN)

EPA Science Inventory

EPA GRANT NUMBER: 0830117
Title: University of California – Center for Environmental Implications of Nanotechnology (UC-CEIN)
Investigator: Andre E. Nel
Institution: University of California - Los Angeles
EPA Project Officer: Nor...

Molecular insight on the non-covalent interactions between carbapenems and uc(l,d)-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study

NASA Astrophysics Data System (ADS)

Ntombela, Thandokuhle; Fakhar, Zeynab; Ibeji, Collins U.; Govender, Thavendran; Maguire, Glenn E. M.; Lamichhane, Gyanu; Kruger, Hendrik G.; Honarparvar, Bahareh

2018-05-01

Tuberculosis remains a dreadful disease that has claimed many human lives worldwide and elimination of the causative agent Mycobacterium tuberculosis also remains elusive. Multidrug-resistant TB is rapidly increasing worldwide; therefore, there is an urgent need for improving the current antibiotics and novel drug targets to successfully curb the TB burden. uc(l,d)-Transpeptidase 2 is an essential protein in Mtb that is responsible for virulence and growth during the chronic stage of the disease. Both uc(d,d)- and uc(l,d)-transpeptidases are inhibited concurrently to eradicate the bacterium. It was recently discovered that classic penicillins only inhibit uc(d,d)-transpeptidases, while uc(l,d)-transpeptidases are blocked by carbapenems. This has contributed to drug resistance and persistence of tuberculosis. Herein, a hybrid two-layered ONIOM (B3LYP/6-31G+(d): AMBER) model was used to extensively investigate the binding interactions of LdtMt2 complexed with four carbapenems (biapenem, imipenem, meropenem, and tebipenem) to ascertain molecular insight of the drug-enzyme complexation event. In the studied complexes, the carbapenems together with catalytic triad active site residues of LdtMt2 (His187, Ser188 and Cys205) were treated at with QM [B3LYP/6-31+G(d)], while the remaining part of the complexes were treated at MM level (AMBER force field). The resulting Gibbs free energy (ΔG), enthalpy (ΔH) and entropy (ΔS) for all complexes showed that the carbapenems exhibit reasonable binding interactions towards LdtMt2. Increasing the number of amino acid residues that form hydrogen bond interactions in the QM layer showed significant impact in binding interaction energy differences and the stabilities of the carbapenems inside the active pocket of LdtMt2. The theoretical binding free energies obtained in this study reflect the same trend of the experimental observations. The electrostatic, hydrogen bonding and Van der Waals interactions between the carbapenems and Ldt

HII 2407: AN ECLIPSING BINARY REVEALED BY K2 OBSERVATIONS OF THE PLEIADES

DOE Office of Scientific and Technical Information (OSTI.GOV)

David, Trevor J.; Hillenbrand, Lynne A.; Zhang, Celia

2015-11-20

The star HII 2407 is a member of the relatively young Pleiades star cluster and was previously discovered to be a single-lined spectroscopic binary. It is newly identified here within Kepler/K2 photometric time series data as an eclipsing binary system. Mutual fitting of the radial velocity and photometric data leads to an orbital solution and constraints on fundamental stellar parameters. While the primary has arrived on the main sequence, the secondary is still pre-main sequence and we compare our results for the M/M{sub ⊙} and R/R{sub ⊙} values with stellar evolutionary models. We also demonstrate that the system is likelymore » to be tidally synchronized. Follow-up infrared spectroscopy is likely to reveal the lines of the secondary, allowing for dynamically measured masses and elevating the system to benchmark eclipsing binary status.« less

EOP and SAA Undergraduates Who Left UC Davis without a Degree.

ERIC Educational Resources Information Center

Rasor, Marianne

Undergraduate students enrolled in the Educational Opportunity Program (EOP) or the Student Affirmative Action (SAA) program at the University of California (UC), Davis, who withdrew before graduation were surveyed in 1981. Attention was directed to the respondents' educational experiences after leaving, their current employment, and their…

UC Davis Fuel Cell, Hydrogen, and Hybrid Vehicle (FCH2V) GATE Center of Excellence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erickson, Paul

This is the final report of the UC Davis Fuel Cell, Hydrogen, and Hybrid Vehicle (FCH2V) GATE Center of Excellence which spanned from 2005-2012. The U.S. Department of Energy (DOE) established the Graduate Automotive Technology Education (GATE) Program, to provide a new generation of engineers and scientists with knowledge and skills to create advanced automotive technologies. The UC Davis Fuel Cell, Hydrogen, and Hybrid Vehicle (FCH2V) GATE Center of Excellence established in 2005 is focused on research, education, industrial collaboration and outreach within automotive technology. UC Davis has had two independent GATE centers with separate well-defined objectives and research programsmore » from 1998. The Fuel Cell Center, administered by ITS-Davis, has focused on fuel cell technology. The Hybrid-Electric Vehicle Design Center (HEV Center), administered by the Department of Mechanical and Aeronautical Engineering, has focused on the development of plug-in hybrid technology using internal combustion engines. The merger of these two centers in 2005 has broadened the scope of research and lead to higher visibility of the activity. UC Davis's existing GATE centers have become the campus's research focal points on fuel cells and hybrid-electric vehicles, and the home for graduate students who are studying advanced automotive technologies. The centers have been highly successful in attracting, training, and placing top-notch students into fuel cell and hybrid programs in both industry and government.« less

Effects of defoliation in the developing leaf zone on young Populus Xeuramericana plants. II. Distribution of UC-photosynthate after defoliation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bassman, J.H.; Dickmann, D.I.

Patterns of UC-photosynthate distribution in growth chamber-grown Populus xeuramericana cv. Negrito de Granada were determined 24 h, 3 weeks, and 5 weeks after defoliation in the developing leaf zone. Translocation patterns were determined by exposing leaves below, within, or above the defoliated zone to UCO2 and determining UC distribution within the plant after 48 h. Translocation patterns were altered within 24 h after defoliation. When leaves below or remaining tissue of leaves within the zone of defoliation were exposed to UCO2, a greater percentage of UC-photosynthate was transported to the expanding shoot and lateral branches and less to the rootsmore » in defoliated plants compared to controls. Little difference between defoliated and control plants and UC distribution occurred when new leaves produced subsequent to defoliation were exposed to UCO2. By 5 weeks after defoliation there was little difference in patterns of UC distribution between defoliated and control plants. These results substantiate biomass partitioning data which showed that a single defoliation of young poplar plants did not affect diameter or height growth, whereas leaf growth was stimulated and root growth reduced.« less

Numerical simulation for turbulent heating around the forebody fairing of H-II rocket

NASA Astrophysics Data System (ADS)

Nomura, Shigeaki; Yamamoto, Yukimitsu; Fukushima, Yukio

Concerning the heat transfer distributions around the nose fairing of the Japanese new launch vehicle H-II rocket, numerical simulations have been conducted for the conditions along its nominal ascent trajectory and some experimental tests have been conducted additionally to confirm the numerical results. The thin layer approximated Navier-Stokes equations with Baldwin-Lomax's algebraic turbulent model were solved by the time dependent finite difference method. Results of numerical simulations showed that a high peak heating would occur near the stagnation point on the spherical nose portion due to the transition to turbulent flow during the period when large stagnation point heating was predicted. The experiments were conducted under the condition of M = 5 and Re = 10 to the 6th which was similar to the flight condition where the maximum stagnation point heating would occur. The experimental results also showed a high peak heating near the stagnation point over the spherical nose portion.

Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism.

PubMed

Chen, Ke; Wang, Ding; Du, Wei Ting; Han, Zhi-Bo; Ren, He; Chi, Ying; Yang, Shao Guang; Zhu, Delin; Bayard, Francis; Han, Zhong Chao

2010-06-01

Human umbilical-cord-derived mesenchymal stem cells (hUC-MSCs) constitute an attractive alternative to bone-marrow-derived MSCs for potential clinical applications because of easy preparation and lower risk of viral contamination. In this study, both proliferation of human peripheral blood mononuclear cells (hPBMCs) and their IFN-gamma production in response to mitogenic or allogeneic stimulus were effectively inhibited by hUC-MSCs. Co-culture experiments in transwell systems indicated that the suppression was largely mediated by soluble factor(s). Blocking experiments identified prostaglandin E(2) (PGE(2)) as the major factor, because inhibition of PGE(2) synthesis almost completely mitigated the immunosuppressive effects, whereas neutralization of TGF-beta, IDO, and NO activities had little effects. Moreover, the inflammatory cytokines, IFN-gamma and IL-1beta, produced by hPBMCs upon activation notably upregulated the expression of cyclooxygenase-2 (COX-2) and the production of PGE(2) by hUC-MSCs. In conclusion, our data have demonstrated for the first time the PGE(2)-mediated mechanism by which hUC-MSCs exert their immunomodulatory effects. Copyright 2010 Elsevier Inc. All rights reserved.

A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region.

PubMed

Wang, H C; Liu, C; He, H Y; Wang, M X

2015-06-01

The incidence of urinary calculus (UC) is very high in Uyghur children in the Kashi region of Xinjiang, China, which seriously affects the growth and life quality of these children. This study was aimed at investigating the risk factors of UC in Uyghur children in Kashi region. One hundred fifteen Uyghur children (age <7 years) with UC who were treated in First People's Hospital in Kashi were enrolled in the case group. A 1:1 case-control study with a questionnaire was performed. The results showed that, among the 115 UC patients, there were more boys (71.3%) than girls (28.7%), and most cases had an onset age of 1-3 years (75.7%). A lower than primary school education in the mother, drinking unboiled water, water intake <500 mL/day, and eating too much sweets were risk factors [odds ratio (OR) = 2.385, 9.160, 3.263, and 8.945, respectively], whereas vegetable intake and exposure to summer sunshine of <2 h/day were protective factors against UC onset (OR = 0.154 and 0.344, respectively). Analysis of UC-related factors in 99 cases of <3-year-old children revealed that breastfeeding was also a protective factor (OR = 0.007), whereas frequent cow's milk intake within 5 months (OR = 2.414) and frequent "panada" intake (OR = 2.529) were risk factors. The occurrence of UC in Uyghur children in the Kashi region is mainly affected by maternal educational background, quality of drinking water, water intake volume, and dietary pattern. Furthermore, geography may also have a role.

Using Optical Markers of Non-dysplastic Rectal Epithelial Cells to Identify Patients With Ulcerative Colitis (UC) - Associated Neoplasia

PubMed Central

Bista, Rajan K.; Brentnall, Teresa A.; Bronner, Mary P.; Langmead, Christopher J.; Brand, Randall E.; Liu, Yang

2011-01-01

BACKGROUND Current surveillance guidelines for patients with long-standing ulcerative colitis (UC) recommend repeated colonoscopy with random biopsies, which is time-consuming, discomforting and expensive. A less invasive strategy is to identify neoplasia by analyzing biomarkers from the more accessible rectum to predict the need for a full colonoscopy. The goal of this pilot study is to evaluate whether optical markers of rectal mucosa derived from a novel optical technique – partial-wave spectroscopic microscopy (PWS) could identify UC patients with high-grade dysplasia (HGD) or cancer (CA) present anywhere in their colon. METHODS Banked frozen non-dysplastic mucosal rectal biopsies were used from 28 UC patients (15 without dysplasia and 13 with concurrent HGD or CA). The specimen slides were made using a touch prep method and underwent PWS analysis. We divided the patients into two groups: 13 as a training set and an independent 15 as a validation set. RESULTS We identified six optical markers, ranked by measuring the information gain with respect to the outcome of cancer. The most effective markers were selected by maximizing the cross validated training accuracy of a Naive Bayes classifier. The optimal classifier was applied to the validation data yielding 100% sensitivity and 75% specificity. CONCLUSIONS Our results indicate that the PWS-derived optical markers can accurately predict UC patients with HGD/CA through assessment of rectal epithelial cells. By aiming for a high sensitivity, our approach could potentially simplify the surveillance of UC patients and improve overall resource utilization by identifying patients with HGD/CA who should proceed with colonoscopy. PMID:21351200

Regional Neuroplastic Brain Changes in Patients with Chronic Inflammatory and Non-Inflammatory Visceral Pain

PubMed Central

Hong, Jui-Yang; Labus, Jennifer S.; Jiang, Zhiguo; Ashe-Mcnalley, Cody; Dinov, Ivo; Gupta, Arpana; Shi, Yonggang; Stains, Jean; Heendeniya, Nuwanthi; Smith, Suzanne R.; Tillisch, Kirsten; Mayer, Emeran A.

2014-01-01

Regional cortical thickness alterations have been reported in many chronic inflammatory and painful conditions, including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS), even though the mechanisms underlying such neuroplastic changes remain poorly understood. In order to better understand the mechanisms contributing to grey matter changes, the current study sought to identify the differences in regional alterations in cortical thickness between healthy controls and two chronic visceral pain syndromes, with and without chronic gut inflammation. 41 healthy controls, 11 IBS subjects with diarrhea, and 16 subjects with ulcerative colitis (UC) underwent high-resolution T1-weighted magnetization-prepared rapid acquisition gradient echo scans. Structural image preprocessing and cortical thickness analysis within the region of interests were performed by using the Laboratory of Neuroimaging Pipeline. Group differences were determined using the general linear model and linear contrast analysis. The two disease groups differed significantly in several cortical regions. UC subjects showed greater cortical thickness in anterior cingulate cortical subregions, and in primary somatosensory cortex compared with both IBS and healthy subjects. Compared with healthy subjects, UC subjects showed lower cortical thickness in orbitofrontal cortex and in mid and posterior insula, while IBS subjects showed lower cortical thickness in the anterior insula. Large effects of correlations between symptom duration and thickness in the orbitofrontal cortex and postcentral gyrus were only observed in UC subjects. The findings suggest that the mechanisms underlying the observed gray matter changes in UC subjects represent a consequence of peripheral inflammation, while in IBS subjects central mechanisms may play a primary role. PMID:24416245

MYSST: Mapping Young Stars in Space and Time - The HII Complex N44 in the LMC

NASA Astrophysics Data System (ADS)

Gouliermis, Dimitrios

2016-10-01

The stellar initial mass function (IMF), and the timescale and lengthscale of star formation (SF) are critical issues for our understanding of how stars form. Low-mass pre-main-sequence (PMS) stars, having typical contraction times on the order of a few 10 Myr, are the live chronometers of the SF process and primary informants on the low-mass IMF of their host clusters. Our studies show that young star clusters, embedded in star-forming regions of the Large Magellanic Cloud (LMC), encompass rich samples of PMS stars, sufficient to study clustered SF in low-metallicities with optical HST photometry. Yet, the lack of a complete comprehensive stellar sample retains important questions about the universality of the IMF, and the time- and length-scale of SF across a typical molecular cloud unanswered. We propose to address these issues by employing both ACS and WFC3 with their high sensitivity and spatial resolving power to obtain deep photometry (m_555 29 mag) of the LMC star-forming complex N44. We will accomplish a detailed mapping of PMS stars that will trace the whole hierarchy of star formation springing from one giant molecular cloud. Our analysis will provide an unbiased determination of the timescale for SF and the sub-solar IMF down to the hydrogen burning limit in a variety of clustering scales for the first time. Our findings will have a significant impact on our comprehensive understanding of SF in the low-metallicity environment of the LMC. We maximize the HST observing efficiency using both ACS/WFC and WFC3/UVIS in parallel for the simultaneous observations of N44, its ensemble of HII regions and their young stellar clusters in the same F555W and F814W filters.

Overexpressed Calponin3 by Subsonic Vibration Induces Neural Differentiation of hUC-MSCs by Regulating the Ionotropic Glutamate Receptor.

PubMed

Kim, Hyun-Jung; Kim, Jin-Hee; Song, Yeo-Ju; Seo, Young-Kwon; Park, Jung-Keug; Kim, Chan-Wha

2015-09-01

In this study, we used proteomics to investigate the effects of sonic vibration (SV) on mesenchymal stem cells derived from human umbilical cords (hUC-MSCs) during neural differentiation to understand how SV enhances neural differentiation of hUC-MSCs. We investigated the levels of gene and protein related to neural differentiation after 3 or 5 days in a group treated with 40-Hz SV. In addition, protein expression patterns were compared between the control and the 40-Hz SV-treated hUC-MSC groups via a proteomic approach. Among these proteins, calponin3 (CNN3) was confirmed to have 299 % higher expression in the 40-Hz SV stimulated hUC-MSCs group than that in the control by Western blotting. Notably, overexpression of CNN3-GFP in Chinese hamster ovary (CHO)-K1 cells had positive effects on the stability and reorganization of F-actin compared with that in GFP-transfected cells. Moreover, CNN3 changed the morphology of the cells by making a neurite-like form. After being subjected to SV, messenger RNA (mRNA) levels of glutamate receptors such as PSD95, GluR1, and NR1 as well as intracellular calcium levels were upregulated. These results suggest that the activity of glutamate receptors increased because of CNN3 characteristics. Taken together, these results demonstrate that overexpressed CNN3 during SV increases expression of glutamate receptors and promotes functional neural differentiation of hUC-MSCs.

What Was It like? Being in the Pioneer Class at UC Merced

ERIC Educational Resources Information Center

Perry, Lisa

2007-01-01

Entering the UC Merced campus and turning onto Scholars Lane, students saw, in this order, large cow pastures surrounding the campus, tall chainlink fences enclosing construction materials, orange fences stating "limits of construction," and across the small road, the residence facilities. Students who were willing to brave this…

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

46 CFR 54.25-8 - Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Radiography (modifies UW-11(a), UCS-57, UNF-57, UHA-33, and UHT-57). 54.25-8 Section 54.25-8 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PRESSURE VESSELS Construction With Carbon, Alloy, and Heat Treated Steels § 54.25-8 Radiography (modifies UW-11(a), UCS-57, UNF...

Serum levels of soluble CD30 are increased in ulcerative colitis (UC) but not in Crohn's disease (CD)

PubMed Central

Giacomelli, R; Passacantando, A; Parzanese, I; Vernia, P; Klidara, N; Cucinelli, F; Lattanzio, R; Santori, E; Cipriani, P; Caprilli, R; Tonietti, G

1998-01-01

Imbalance in Th1 and Th2 subsets and their derived cytokines seems to be involved in the immune abnormalities underlying UC and CD. CD30 is a member of the tumour necrosis factor/nerve growth receptor superfamily expressed on T cells producing Th2 cytokines and released as a soluble form. In this study high levels of soluble CD30 were found in sera of UC patients independently of disease activity. Furthermore, increased titres of soluble CD30 molecule were shown, in the same patients, by mitogen-stimulated cultures of peripheral blood mononuclear cells. Our data seem to indicate that an activation of Th2 immune response is involved in the pathogenesis of UC, but not of CD. Furthermore, this finding indicates that serum soluble CD30 measurement may be helpful for differentiating these two forms of inflammatory bowel disease. PMID:9528894

Total Ionizing Dose Test Report for the UC1823A Pulse Width Modulator

NASA Technical Reports Server (NTRS)

Chen, Dakai; Forney, James

2017-01-01

The purpose of this study is to examine the total ionizing dose susceptibility for the UC1823A pulse width modulator manufactured by Texas Instruments, Inc. The part is suspected to be vulnerable to enhanced low dose rate sensitivity (ELDRS).

Molecular dynamics approach to water structure of HII mesophase of monoolein

NASA Astrophysics Data System (ADS)

Kolev, Vesselin; Ivanova, Anela; Madjarova, Galia; Aserin, Abraham; Garti, Nissim

2012-02-01

The goal of the present work is to study theoretically the structure of water inside the water cylinder of the inverse hexagonal mesophase (HII) of glyceryl monooleate (monoolein, GMO), using the method of molecular dynamics. To simplify the computational model, a fixed structure of the GMO tube is maintained. The non-standard cylindrical geometry of the system required the development and application of a novel method for obtaining the starting distribution of water molecules. A predictor-corrector schema is employed for generation of the initial density of water. Molecular dynamics calculations are performed at constant volume and temperature (NVT ensemble) with 1D periodic boundary conditions applied. During the simulations the lipid structure is kept fixed, while the dynamics of water is unrestrained. Distribution of hydrogen bonds and density as well as radial distribution of water molecules across the water cylinder show the presence of water structure deep in the cylinder (about 6 Å below the GMO heads). The obtained results may help understanding the role of water structure in the processes of insertion of external molecules inside the GMO/water system. The present work has a semi-quantitative character and it should be considered as the initial stage of more comprehensive future theoretical studies.

Production of UC-labeled gas in BACTEC Neisseria Differentiation kits by Neisseria cinerea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyce, J.M.; Mitchell, E.B. Jr.; Knapp, J.S.

1985-09-01

Six strains of Neisseria cinerea were tested in BACTEC Neisseria Differentiation kits (Johnston Laboratories, Inc., Towson, Md.), and all yielded positive glucose growth indices and negative maltose and fructose growth indices. These results were similar to those achieved with Neisseria gonorrhoeae. However, most of the N. cinerea isolates tested yielded 3-h glucose growth indices that were lower than those obtained with gonococci. UC-labeled gas was produced significantly faster by N. gonorrhoeae than by N. cinerea. Additional studies suggested that the UC-labeled gas produced by N. cinerea was carbon dioxide. N. cinerea strains were similar to Branhamella catarrhalis strains because bothmore » species failed to produce detectable acid from glucose, maltose, sucrose, fructose, and lactose in cysteine-tryptic agar media. However, in contrast to N. cinerea strains, B. catarrhalis strains did not metabolize glucose in BACTEC Neisseria Differentiation kits.« less

Initial source and site characterization studies for the U.C. Santa Barbara campus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archuleta, R.; Nicholson, C.; Steidl, J.

1997-12-01

The University of California Campus-Laboratory Collaboration (CLC) project is an integrated 3 year effort involving Lawrence Livermore National Laboratory (LLNL) and four UC campuses - Los Angeles (UCLA), Riverside (UCR), Santa Barbara (UCSB), and San Diego (UCSD) - plus additional collaborators at San Diego State University (SDSU), at Los Alamos National Laboratory and in industry. The primary purpose of the project is to estimate potential ground motions from large earthquakes and to predict site-specific ground motions for one critical structure on each campus. This project thus combines the disciplines of geology, seismology, geodesy, soil dynamics, and earthquake engineering into amore » fully integrated approach. Once completed, the CLC project will provide a template to evaluate other buildings at each of the four UC campuses, as well as provide a methodology for evaluating seismic hazards at other critical sites in California, including other UC locations at risk from large earthquakes. Another important objective of the CLC project is the education of students and other professional in the application of this integrated, multidisciplinary, state-of-the-art approach to the assessment of earthquake hazard. For each campus targeted by the CLC project, the seismic hazard study will consist of four phases: Phase I - Initial source and site characterization, Phase II - Drilling, logging, seismic monitoring, and laboratory dynamic soil testing, Phase III - Modeling of predicted site-specific earthquake ground motions, and Phase IV - Calculations of 3D building response. This report cover Phase I for the UCSB campus and incudes results up through March 1997.« less

UC Berkeley's Celebration of the International Year of Astronomy 2009

NASA Astrophysics Data System (ADS)

Cobb, B. E.; Croft, S.; Silverman, J. M.; Klein, C.; Modjaz, M.

2010-08-01

We present the astronomy outreach efforts undertaken for the International Year of Astronomy 2009 at the University of California, Berkeley. Our department-wide endeavors included a monthly public lecture series by UC Berkeley astronomers and a major astronomy outreach event during a campus-wide university "open house," which included solar observing and a Starlab Planetarium. In addition to sharing our outreach techniques and outcomes, we discuss some of our unique strategies for advertising our events to the local community.

Distinguishing between HII regions and planetary nebulae with Hi-GAL, WISE, MIPSGAL, and GLIMPSE

NASA Astrophysics Data System (ADS)

Anderson, L. D.; Zavagno, A.; Barlow, M. J.; García-Lario, P.; Noriega-Crespo, A.

2012-01-01

Context. H II regions and planetary nebulae (PNe) both emit at radio and infrared (IR) wavelengths, and angularly small H II regions can be mistaken for PNe. This problem of classification is most severe for H II regions in an early evolutionary stage, those that are extremely distant, or those that are both young and distant. Previous work has shown that H II regions and PNe can be separated based on their infrared colors. Aims: Using data from the Herschel Hi-GAL survey, as well as WISE and the Spitzer MIPSGAL and GLIMPSE surveys, we wish to establish characteristic IR colors that can be used to distinguish between H II regions and PNe. Methods: We perform aperture photometry measurements for a sample of 126 H II regions and 43 PNe at wavelengths from 8.0 μm to 500 μm. Results: We find that H II regions and PNe have distinct IR colors. The most robust discriminating color criteria are [F12/F8] < 0.3, [F160/F12] > 1.3, and [F160/F24] > 0.8 (or alternately [F160/F22] > 0.8), where the brackets indicate the log of the flux ratio. All three of these criteria are individually satisfied by over 98% of our sample of H II regions and by ~10% of our sample of PNe. Combinations of these colors are more robust in separating the two populations; for example all H II regions and no PNe satisfy [F12/F8] < 0.4 and [F160/F22] > 0.8. When applied to objects of unknown classification, these criteria prove useful in separating the two populations. The dispersion in color is relatively small for H II regions; this suggests that any evolution in these colors with time for H II regions must be relatively modest. The spectral energy distributions (SEDs) of H II regions can be separated into "warm" and "cold" components. The "cold" component is well-fit by a grey-body of temperature 25 K. The SEDs of nearly two-thirds of our sample of H II regions peak at 160 μm and one third peak at 70 μm. For PNe, 67% of the SEDs peak at 70 μm, 23% peak at either 22 μm or 24 μm, and 9% (two

H II Regions in the Disks of Spiral Galaxies

NASA Astrophysics Data System (ADS)

Rozas, M.

1997-06-01

The objective of the research presented in the thesis is to use photometrically calibrated high quality images in \\ha\\ of the disks of spiral galaxies to study their global star forming properties. In the first part of the study we catalog and study statistically the \\hii\\ regions in a set of spirals, imaged in \\ha\\ . The observed parameters of each region are its fluxes and diameters, from which we can also derive the mean surface brightness and its internal radial gradient (the latter for the largest most luminous regions). Plotting the luminosity function (LF) for a given galaxy (the number of regions versus \\ha\\ flux) we find a characteristic discontinuity: a peak accompanied by a change in gradient of the function, at a luminosity of 10$^{38.6}$ erg s$^{-1}$ per region. We attribute this to the change from ionization-bounded \\hii\\ regions, at luminosities below the transition, to density-bounded regions above the transition, and explain with a quantitative model based on this assumption why the transition takes place at a well-defined luminosity, and one which varies very little from galaxy to galaxy. In the six galaxies observed and analyzed in this way, the variance is 0.07 mag., making the transition a good prima facie candidate to be a powerful standard candle for accurate extragalactic distance measurements. Confirmation of the nature of the transition is provided by measurements of the internal brightness gradients, which show a jump from a constant value (predicted for ionization bounded regions) below the transition to a larger and increasing value above the transition. The theoretical model which can account for the transition was used to show how the gradients of the LF in the ionization bounded and the density bounded regimes can be used to derive the mass function of the ionizing stars in regions close to the transition luminosity, yielding a mean value for the slope of the MF in the galaxies observed of -2.4; the brightest stars in these

Linking academic and clinical missions: UC Davis' integrated AHC.

PubMed

Pomeroy, Claire; Rice, Ann; McGowan, William; Osburn, Nathan

2008-09-01

Academic health centers (AHCs) rely on cross-subsidization of education and research programs by the clinical enterprise, but this is becoming more challenging as clinical reimbursements decline. These new realities provide an important opportunity to reevaluate the relationships between medical schools and academic medical centers. The authors examine the benefits of their ongoing commitment to create a fully integrated AHC at the University of California (UC) Davis, discussing strategies that serve as catalysts for continued growth. They explore how investments of proceeds from the clinical enterprise directly enhance educational and research initiatives, which, in turn, increase the success of patient-care programs. This has created a cycle of excellence that leads to an enhanced reputation for the entire health system. One strategy involves using clinical margins to "prime the pump" in anticipation of major research initiatives, resulting in rapid increases in external research funding and academic recognition. In turn, this facilitates recruitment of high-quality faculty and staff, improving the ability to deliver expert clinical care. The overall enhanced institutional reputation positions both the clinical and academic programs for further success. The authors posit that such approaches require executive-level commitment to a single strategic vision, unified leadership, and collaborative financial and operational decision making. Adopting such changes is not without challenges, which are discussed, but the authors suggest that an integrated AHC fosters optimized operations, enhanced reputation, and stronger performance across all mission areas. They also provide examples of how the UC Davis Health System has thus attracted philanthropists and investments from the private sector.

Structural studies of the cell wall polysaccharide from Lactococcus lactis UC509.9.

PubMed

Vinogradov, Evgeny; Sadovskaya, Irina; Grard, Thierry; Murphy, James; Mahony, Jennifer; Chapot-Chartier, Marie-Pierre; van Sinderen, Douwe

2018-05-22

Lactococcus lactis is the most widely utilised starter bacterial species in dairy fermentations. The L. lactis cell envelope contains polysaccharides, which, among other known functions, serve as bacteriophage receptors. Our previous studies have highlighted the structural diversity of these so-called cell wall polysaccharides (CWPSs) among L. lactis strains that could account for the narrow host range of most lactococcal bacteriophages. In the present work, we studied the CWPS of L. lactis strain UC509.9, an Irish dairy starter strain that is host to the temperate and well-characterized P335-type phage Tuc2009. The UC509.9 CWPS structure was analyzed by methylation, deacetylation/deamination, Smith degradation and 2D NMR spectroscopy. The CWPS consists of a linear backbone composed of a tetrasaccharide repeat unit, partially substituted with a branched phosphorylated oligosaccharide having a common trisaccharide and three non-stoichiometric substitutions. Copyright © 2018 Elsevier Ltd. All rights reserved.

Examination of electromagnetic powers with the example of a uc(Faraday) disc dynamo

NASA Astrophysics Data System (ADS)

Reich, Felix A.; Müller, Wolfgang H.

2018-03-01

This paper studies the mathematical form of electromagnetic powers and their influence on the balance of energy by using the example of a uc(Faraday) disc. First, two forms of energy (and balances thereof) are discussed. These employ different forms of powers, which can be distinguished w.r.t. their physical origins and their interpretations in context with the notions of supply and production. The stationary uc(Faraday) disc experiment is modeled following the description by Kovetz (Electromagnetic theory, Oxford University Press, Oxford, 2000). Concepts for formulating the electromagnetic field equations for the rotating disc are discussed, and the corresponding approximate analytical solutions are presented. Based on the obtained electromagnetic fields, the powers of the disc are analyzed for a stationary process. The conversion of mechanical power to heating and electromagnetic powering of an external resistor is explained. The paper concludes with the computation of the time evolution of the angular velocity for a magnetically induced breaking process of the disc.

The Impact of Diffuse Ionized Gas on Emission-line Ratios and Gas Metallicity Measurements

NASA Astrophysics Data System (ADS)

Zhang, Kai; Yan, Renbin; MaNGA Team

2016-01-01

Diffuse Ionized Gas (DIG) is prevalent in star-forming galaxies. Using a sample of galaxies observed by MaNGA, we demonstrate how DIG in star-forming galaxies impact the measurements of emission line ratios, hence the gas-phase metallicity measurements and the interpretation of diagnostic diagrams. We demonstrate that emission line surface brightness (SB) is a reasonably good proxy to separate HII regions from regions dominated by diffuse ionized gas. For spatially-adjacent regions or regions at the same radius, many line ratios change systematically with emission line surface brightness, reflecting a gradual increase of dominance by DIG towards low SB. DIG could significantly bias the measurement of gas metallicity and metallicity gradient. Because DIG tend to have a higher temperature than HII regions, at fixed metallicity DIG displays lower [NII]/[OII] ratios. DIG also show lower [OIII]/[OII] ratios than HII regions, due to extended partially-ionized regions that enhance all low-ionization lines ([NII], [SII], [OII], [OI]). The contamination by DIG is responsible for a substantial portion of the scatter in metallicity measurements. At different surface brightness, line ratios and line ratio gradients can differ systematically. As DIG fraction could change with radius, it can affect the metallicity gradient measurements in systematic ways. The three commonly used strong-line metallicity indicators, R23, [NII]/[OII], O3N2, are all affected in different ways. To make robust metallicity gradient measurements, one has to properly isolate HII regions and correct for DIG contamination. In line ratio diagnostic diagrams, contamination by DIG moves HII regions towards composite or LINER-like regions.

Mutational Hotspots in the Mitochondrial D-Loop Region of Cancerous and Precancerous Colorectal Lesions in Egyptian Patients

PubMed Central

El-Guendy, Nadia; Tantawy, Marwa; Abdelhady, Hala; El-Ghor, Akmal; Abdel Wahab, Abdel Hady

2011-01-01

Mutations in the mitochondrial genome (mtDNA) are associated with different types of cancer, specifically colorectal cancer (CRC). However, few studies have been performed on precancerous lesions, such as ulcerative colitis (UC) lesions and adenomatous polyps (AP). The aim of this study was to identify mtDNA mutations in the cancerous and precancerous lesions of Egyptian patients. An analysis of the mutations found in six regions of the mtDNA genome (ND1, ND5, COI, tRNAser, D-loop 1, and 2) in 80 Egyptian patients (40 CRC, 20 UC, and 20 AP) was performed using polymerase chain reaction–single-strand conformational polymorphism techniques and followed up by direct sequencing. The overall incidence of mutations was 25%, 25%, and 35% in CRC, UC, and AP cases, respectively. Although there was no common mutation pattern within each group, a large number of mutations were detected in the D-loop region in all of the groups. Some mutations (e.g., T414G) were detected repeatedly in precancerous (UC and AP) and cancerous lesions. Mutations detected in patients with CRC were predominantly found in the ND1 gene (40%). Our preliminary study suggests that Egyptian patients with CRC have a large number of mtDNA mutations, especially in the D-loop region, which have not been previously reported. Mutations in the mtDNA of precancerous lesions (i.e., AP and UC) may contribute to transformation events that lead to CRC. PMID:21612400

Draft Genome Sequence of Vancomycin-Heteroresistant Staphylococcus epidermidis Strain UC7032, Isolated from Food

PubMed Central

Pietta, Ester; Bassi, Daniela; Fontana, Cecilia; Puglisi, Edoardo; Cappa, Fabrizio; Cocconcelli, Pier Sandro

2013-01-01

Staphylococcus epidermidis strain UC7032 was isolated from ready-to-eat cured meat and is heteroresistant to glycopeptide antibiotics. The draft whole-genome analysis revealed that this strain shows common characteristics typical of strains that are involved in nosocomial infections. PMID:24072859

Sixteen years of collaborative learning through active sense-making in physics (CLASP) at UC Davis

NASA Astrophysics Data System (ADS)

Potter, Wendell; Webb, David; Paul, Cassandra; West, Emily; Bowen, Mark; Weiss, Brenda; Coleman, Lawrence; De Leone, Charles

2014-02-01

This paper describes our large reformed introductory physics course at UC Davis, which bioscience students have been taking since 1996. The central feature of this course is a focus on sense-making by the students during the 5 h per week discussion/labs in which the students take part in activities emphasizing peer-peer discussions, argumentation, and presentations of ideas. The course differs in many fundamental ways from traditionally taught introductory physics courses. After discussing the unique features of CLASP and its implementation at UC Davis, various student outcome measures are presented that show increased performance by students who took the CLASP course compared to students who took a traditionally taught introductory physics course. Measures we use include upper-division GPAs, MCAT scores, FCI gains, and MPEX-II scores.

The Massive Stellar Population in the Diffuse Ionized Gas of M33

NASA Technical Reports Server (NTRS)

Hoopes, Charles G.; Walterbos, Rene A. M.

1995-01-01

We compare Far-UV, H alpha, and optical broadband images of the nearby spiral galaxy M33, to investigate the massive stars associated with the diffuse ionized gas. The H-alpha/FUV ratio is higher in HII regions than in the DIG, possibly indicating that an older population ionizes the DIG. The broad-band colors support this conclusion. The HII region population is consistent with a young burst, while the DIG colors resemble an older population with constant star formation. Our results indicate that there may be enough massive field stars to ionize the DIG, without the need for photon leakage from HII regions.

Creating an Engaging Library Orientation: First Year Experience Courses at UC San Diego

ERIC Educational Resources Information Center

Goldman, Crystal; Turnbow, Dominique; Roth, Amanda; Friedman, Lia; Heskett, Karen

2016-01-01

This article focuses on the development of an engaging library orientation module for UC San Diego First Year Experience (FYE) courses. The library module included a brief in-class presentation about research concepts and library services, an online interactive library scavenger hunt given as an in-class activity, and a homework assignment where…

H-II Transfer Vehicle (HTV) and the Operations Concept for Extravehicular Activity (EVA) Hardware

NASA Technical Reports Server (NTRS)

Chullen, Cinda

2010-01-01

With the retirement of the Space Shuttle fleet imminent in 2011, a new concept of operations will become reality to meet the transportation challenges of the International Space Station (ISS). The planning associated with the retirement of the Space Shuttle has been underway since the announcement in 2004. Since then, several companies and government entities have had to look for innovative low-cost commercial orbital transportation systems to continue to achieve the objectives of ISS delivery requirements. Several options have been assessed and appear ready to meet the large and demanding delivery requirements of the ISS. Options that have been identified that can facilitate the challenge include the Russian Federal Space Agency's Soyuz and Progress spacecraft, European Space Agency's Automated Transfer Vehicle (ATV), the Japan Aerospace Exploration Agency's (JAXA's) H-II Transfer Vehicle (HTV) and the Boeing Delta IV Heavy (DIV-H). The newest of these options is the JAXA's HTV. This paper focuses on the HTV, mission architecture and operations concept for Extra-Vehicular Activities (EVA) hardware, the associated launch system, and details of the launch operations approach.

H-II Transfer Vehicle (HTV) and the Operations Concept for Extravehicular Activity (EVA) Hardware

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Blome, Elizabeth; Tetsuya, Sakashita

2011-01-01

With the retirement of the Space Shuttle fleet imminent in 2011, a new operations concept will become reality to meet the transportation challenges of the International Space Station (ISS). The planning associated with the retirement of the Space Shuttle has been underway since the announcement in 2004. Since then, several companies and government entities have had to look for innovative low-cost commercial orbital transportation systems to continue to achieve the objectives of ISS delivery requirements. Several options have been assessed and appear ready to meet the large and demanding delivery requirements of the ISS. Options that have been identified that can facilitate the challenge include the Russian Federal Space Agency's Soyuz and Progress spacecraft, European Space Agency's Automated Transfer Vehicle (ATV), and the Japan Aerospace Exploration Agency's (JAXA s) H-II Transfer Vehicle (HTV). The newest of these options is the JAXA's HTV. This paper focuses on the HTV, mission architecture and operations concept for Extra-Vehicular Activities (EVA) hardware, the associated launch system, and details of the launch operations approach.

Lyman-continuum leakage as dominant source of diffuse ionized gas in the Antennae galaxy

NASA Astrophysics Data System (ADS)

Weilbacher, Peter M.; Monreal-Ibero, Ana; Verhamme, Anne; Sandin, Christer; Steinmetz, Matthias; Kollatschny, Wolfram; Krajnović, Davor; Kamann, Sebastian; Roth, Martin M.; Erroz-Ferrer, Santiago; Marino, Raffaella Anna; Maseda, Michael V.; Wendt, Martin; Bacon, Roland; Dreizler, Stefan; Richard, Johan; Wisotzki, Lutz

2018-04-01

The Antennae galaxy (NGC 4038/39) is the closest major interacting galaxy system and is therefore often studied as a merger prototype. We present the first comprehensive integral field spectroscopic dataset of this system, observed with the MUSE instrument at the ESO VLT. We cover the two regions in this system which exhibit recent star formation: the central galaxy interaction and a region near the tip of the southern tidal tail. In these fields, we detect HII regions and diffuse ionized gas to unprecedented depth. About 15% of the ionized gas was undetected by previous observing campaigns. This newly detected faint ionized gas is visible everywhere around the central merger, and shows filamentary structure. We estimate diffuse gas fractions of about 60% in the central field and 10% in the southern region. We are able to show that the southern region contains a significantly different population of HII regions, showing fainter luminosities. By comparing HII region luminosities with the HST catalog of young star clusters in the central field, we estimate that there is enough Lyman-continuum leakage in the merger to explain the amount of diffuse ionized gas that we detect. We compare the Lyman-continuum escape fraction of each HII region against emission line ratios that are sensitive to the ionization parameter. While we find no systematic trend between these properties, the most extreme line ratios seem to be strong indicators of density bounded ionization. Extrapolating the Lyman-continuum escape fractions to the southern region, we conclude that simply from the comparison of the young stellar populations to the ionized gas there is no need to invoke other ionization mechanisms than Lyman-continuum leaking HII regions for the diffuse ionized gas in the Antennae. FITS images and Table of HII regions are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/611/A95 and at http://muse-vlt.eu/science/antennae/

Design and synthesis of a novel multifunctional stabilizer for highly stable uc(dl)-tetrahydropalmatine nanosuspensions and in vitro study

NASA Astrophysics Data System (ADS)

Yan, Beibei; Wang, Yancai; Wang, Lulu; Zhou, Yuqi; Shang, Xueyun; Zhao, Juan; Liu, Yangyang; Du, Juan

2018-05-01

The present study aimed to prepare stable uc(dl)-tetrahydropalmatine (uc(dl)-THP) nanosuspensions of optimized formulation with PEGylated chitosan as a multifunctional stabilizer using the antisolvent precipitation method. A central composite design project of three factors and five-level full factorial (53) was applied to design the experimental program, and response surface methodology analysis was used to optimize the experimental conditions. The effects of critical influencing factors such as PEGylated chitosan concentration, operational temperature, and ultrasonic energy on particle size and zeta potential were investigated. Under the optimization nanosuspension formulation, the particle size was 269 nm and zeta potential was at 37.4 mV. Also, the uc(dl)-THP nanosuspensions maintained good physical stability after 2 months, indicating the potential ability of the multifunctional stabilizer for stable nanosuspension formulation. Hence, the present findings indicated that PEGylated chitosan could be used as the ideal stabilizer to form a physically stable nanosuspension formulation.

Theoretical study of actinide monocarbides (ThC, UC, PuC, and AmC)

NASA Astrophysics Data System (ADS)

Pogány, Peter; Kovács, Attila; Visscher, Lucas; Konings, Rudy J. M.

2016-12-01

A study of four representative actinide monocarbides, ThC, UC, PuC, and AmC, has been performed with relativistic quantum chemical calculations. The two applied methods were multireference complete active space second-order perturbation theory (CASPT2) including the Douglas-Kroll-Hess Hamiltonian with all-electron basis sets and density functional theory with the B3LYP exchange-correlation functional in conjunction with relativistic pseudopotentials. Beside the ground electronic states, the excited states up to 17 000 cm-1 have been determined. The molecular properties explored included the ground-state geometries, bonding properties, and the electronic absorption spectra. According to the occupation of the bonding orbitals, the calculated electronic states were classified into three groups, each leading to a characteristic bond distance range for the equilibrium geometry. The ground states of ThC, UC, and PuC have two doubly occupied π orbitals resulting in short bond distances between 1.8 and 2.0 Å, whereas the ground state of AmC has significant occupation of the antibonding orbitals, causing a bond distance of 2.15 Å.

Distribution of water in the G327.3-0.6 massive star-forming region

NASA Astrophysics Data System (ADS)

Leurini, S.; Herpin, F.; van der Tak, F.; Wyrowski, F.; Herczeg, G. J.; van Dishoeck, E. F.

2017-06-01

Aims: Following our past study of the distribution of warm gas in the G327.3-0.6 massive star-forming region, we aim here at characterizing the large-scale distribution of water in this active region of massive star formation made of individual objects in different evolutionary phases. We investigate possible variations of the water abundance as a function of evolution. Methods: We present Herschel/PACS (4'× 4') continuum maps at 89 and179 μm encompassing the whole region (Hii region and the infrared dark cloud, IRDC) and an APEX/SABOCA (2'× 2') map at 350 μm of the IRDC. New spectral Herschel/HIFI maps toward the IRDC region covering the low-energy water lines at 987 and 1113 GHz (and their H218O counterparts) are also presented and combined with HIFI pointed observations toward the G327 hot core region. We infer the physical properties of the gas through optical depth analysis and radiative transfer modeling of the HIFI lines. Results: The distribution of the continuum emission at 89 and 179 μm follows the thermal continuum emission observed at longer wavelengths, with a peak at the position of the hot core and a secondary peak in the Hii region, and an arch-like layer of hot gas west of this Hii region. The same morphology is observed in the p-H2O 111-000 line, in absorption toward all submillimeter dust condensations. Optical depths of approximately 80 and 15 are estimated and correspond to column densities of 1015 and 2 × 1014 cm-2, respectively, for the hot core and IRDC position. These values indicate an abundance of water relative to H2 of 3 × 10-8 toward the hot core, while the abundance of water does not change along the IRDC with values close to some 10-8. Infall (over at least 20″) is detected toward the hot core position with a rate of 1-1.3 × 10-2M⊙ /yr, high enough to overcome the radiation pressure that is due to the stellar luminosity. The source structure of the hot core region appears complex, with a cold outer gas envelope in

LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells.

PubMed

Chen, Ting; Gu, Chengxin; Xue, Cailin; Yang, Tao; Zhong, Yun; Liu, Shiming; Nie, Yuqiang; Yang, Hui

2017-01-01

Long non-coding RNAs (lncRNAs) have been implicated in liver carcinogenesis. We previously showed that the induction of lncRNA-uc002mbe.2 is positively associated with the apoptotic effect of trichostatin A (TSA) in hepatocellular carcinoma (HCC) cells. The current study further analyzed the role of uc002mbe.2 in TSA-induced liver cancer cell death. The level of uc002mbe.2 was markedly increased by TSA in the cytoplasm of HCC cells. Knockdown of uc002mbe.2 prohibited TSA-induced G2/M cell cycle arrest, p21 induction, and apoptosis of Huh7 cells and reversed the TSA-mediated decrease in p-AKT. RNA pull-down and RNA-binding protein immunoprecipitation (RIP) assays revealed that TSA induced an interaction between uc002mbe.2 and heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in Huh7 cells. This interaction mediated AKT deactivation and p21 induction in liver cancer cells. In an athymic xenograft mouse model, knockdown of uc002mbe.2 significantly prohibited the TSA-mediated reduction in tumor size and weight. In addition, the ability of TSA to reduce hnRNPA2B1 and p-AKT levels and induce p21 in the xenograft tumors was prevented by uc002mbe.2 knockdown. Therefore, the interaction of uc002mbe.2 and hnRNPA2B1 in mediating AKT deactivation and p21 induction is involved in the cytostatic effect of trichostatin in liver cancer cells.

LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia.

PubMed

Wang, Shouyu; Xu, Hong; Zou, Lifang; Xie, Jinyang; Wu, Hong; Wu, Bing; Yi, Zhihua; Lv, Qiulan; Zhang, Xi; Ying, Mofeng; Liu, Shuangmei; Li, Guilin; Gao, Yun; Xu, Changshui; Zhang, Chunping; Xue, Yun; Liang, Shangdong

2016-03-01

Some long non-coding RNAs (lncRNAs) participate in physiological processes that maintain cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs is involved in the onset and progression of many pathological conditions. Research has indicated that the genetic knockout of some lncRNAs in mice resulted in peri- or postnatal lethality or developmental defects. Diabetes mellitus (DM) is a major cause of peripheral neuropathy. Our studies showed that the expression levels of lncRNA uc.48+ in the diabetic rat dorsal root ganglia (DRG) and the DM patients' serum samples were increased. It suggested that lncRNA uc.48+ was involved in the pathophysiological process of DM. The aim of this study was to investigate the effects of lncRNA uc.48+ small interfering RNA (siRNA) on diabetic neuropathic pain (DNP) mediated by the P2X3 receptor in the DRG. The values of the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured by the von Frey test and Hargreaves' test, respectively. The levels of P2X3 protein and messenger RNA (mRNA) in the DRG were detected by reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and western blotting. The experiments showed that the MWT and TWL values in DM rats were lower than those in the control rats. The MWT and TWL values in DM rats treated with lncRNA uc.48+ siRNA were increased compared to those in DM rats, but there was no significant difference between the DM rat group and the DM + scramble siRNA group. The levels of P2X3 protein and mRNA in the DM DRG were higher than those in the control, while the levels of P2X3 protein and mRNA in the DG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in DM rats. The expression levels of TNF-α in the DRG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in the DM group. The phosphorylation and activation of ERK1/2 in the DM DRG were decreased by

In Vitro Evaluation of Nonnucleoside Reverse Transcriptase Inhibitors UC-781 and TMC120-R147681 as Human Immunodeficiency Virus Microbicides†

PubMed Central

Van Herrewege, Yven; Michiels, Jo; Van Roey, Jens; Fransen, Katrien; Kestens, Luc; Balzarini, Jan; Lewi, Paul; Vanham, Guido; Janssen, Paul

2004-01-01

The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV. PMID:14693562

Long Noncoding RNA uc002yug.2 Activates HIV-1 Latency through Regulation of mRNA Levels of Various RUNX1 Isoforms and Increased Tat Expression.

PubMed

Huan, Chen; Li, Zhaolong; Ning, Shanshan; Wang, Hong; Yu, Xiao-Fang; Zhang, Wenyan

2018-05-01

The HIV-1 reservoir is a major obstacle to complete eradication of the virus. Although many proteins and RNAs have been characterized as regulators in HIV-1/AIDS pathogenesis and latency, only a few long noncoding RNAs (lncRNAs) have been shown to be closely associated with HIV-1 replication and latency. In this study, we demonstrated that lncRNA uc002yug.2 plays a key role in HIV-1 replication and latency. uc002yug.2 potentially enhances HIV-1 replication, long terminal repeat (LTR) activity, and the activation of latent HIV-1 in both cell lines and CD4 + T cells from patients. Further investigation revealed that uc002yug.2 activates latent HIV-1 through downregulating RUNX1b and -1c and upregulating Tat protein expression. The accumulated evidence supports our model that the Tat protein has the key role in the uc002yug.2-mediated regulatory effect on HIV-1 reactivation. Moreover, uc002yug.2 showed an ability to activate HIV-1 similar to that of suberoylanilide hydroxamic acid or phorbol 12-myristate 13-acetate using latently infected cell models. These findings improve our understanding of lncRNA regulation of HIV-1 replication and latency, providing new insights into potential targeted therapeutic interventions. IMPORTANCE The latent viral reservoir is the primary obstacle to curing HIV-1 disease. To date, only a few lncRNAs, which play major roles in various biological processes, including viral infection, have been identified as regulators in HIV-1 latency. In this study, we demonstrated that lncRNA uc002yug.2 is important for both HIV-1 replication and activation of latent viruses. Moreover, uc002yug.2 was shown to activate latent HIV-1 through regulating alternative splicing of RUNX1 and increasing the expression of Tat protein. These findings highlight the potential merit of targeting lncRNA uc002yug.2 as an activating agent for latent HIV-1. Copyright © 2018 American Society for Microbiology.

Populations of High-Luminosity Density-Bounded HII Regions in Spiral Galaxies? Evidence and Implications

NASA Technical Reports Server (NTRS)

Beckman, J. E.; Rozas, M.; Zurita, A.; Watson, R. A.; Knapen, J. H.

2000-01-01

In this paper we present evidence that the H II regions of high luminosity in disk galaxies may be density bounded, so that a significant fraction of the ionizing photons emitted by their exciting OB stars escape from the regions. The key piece of evidence is the presence, in the Ha luminosity functions (LFs) of the populations of H iI regions, of glitches, local sharp peaks at an apparently invariant luminosity, defined as the Stromgren luminosity Lstr), LH(sub alpha) = Lstr = 10(sup 38.6) (+/- 10(sup 0.1)) erg/ s (no other peaks are found in any of the LFs) accompanying a steepening of slope for LH(sub alpha) greater than Lstr This behavior is readily explicable via a physical model whose basic premises are: (a) the transition at LH(sub alpha) = Lstr marks a change from essentially ionization bounding at low luminosities to density bounding at higher values, (b) for this to occur the law relating stellar mass in massive star-forming clouds to the mass of the placental cloud must be such that the ionizing photon flux produced within the cloud is a function which rises more steeply than the mass of the cloud. Supporting evidence for the hypothesis of this transition is also presented: measurements of the central surface brightnesses of H II regions for LH(sub alpha) less than Lstr are proportional to L(sup 1/3, sub H(sub alpha)), expected for ionization bounding, but show a sharp trend to a steeper dependence for LH(sub alpha) greater than Lstr, and the observed relation between the internal turbulence velocity parameter, sigma, and the luminosity, L, at high luminosities, can be well explained if these regions are density bounded. If confirmed, the density-bounding hypothesis would have a number of interesting implications. It would imply that the density-bounded regions were the main sources of the photons which ionize the diffuse gas in disk galaxies. Our estimates, based on the hypothesis, indicate that these regions emit sufficient Lyman continuum not only to

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.

PubMed

Fischer, Anika; Zundler, Sebastian; Atreya, Raja; Rath, Timo; Voskens, Caroline; Hirschmann, Simon; López-Posadas, Rocío; Watson, Alastair; Becker, Christoph; Schuler, Gerold; Neufert, Clemens; Atreya, Imke; Neurath, Markus F

2016-10-01

Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15. We assessed the expression of homing receptors on T cells in peripheral blood and inflamed mucosa. We studied the migration pattern and homing of Teff and Treg cells to the inflamed gut using intravital confocal microscopy and FACS in a humanised mouse model in dextran sodium sulfate-treated NSG (NOD.Cg-Prkdcscid-Il2rgtm1Wjl/SzJ) mice. Expression of GPR15 and α4β7 was significantly increased on Treg rather than Teff cells in peripheral blood of patients with UC as compared with Crohn's disease and controls. In vivo analysis in a humanised mouse model showed augmented gut homing of UC Treg cells as compared with controls. Moreover, suppression of UC (but not control) Teff and Treg cell homing was noted upon treatment with the α4β7 antibody vedolizumab. In contrast, siRNA blockade of GPR15 had only effects on homing of Teff cells but did not affect Treg homing in UC. Clinical vedolizumab treatment was associated with marked expansion of UC Treg cells in peripheral blood. α4β7 rather than GPR15 is crucial for increased colonic homing of UC Treg cells in vivo, while both receptors control UC Teff cell homing. Vedolizumab treatment impairs homing of UC Treg cells leading to their accumulation in peripheral blood with subsequent suppression of systemic Teff cell expansion. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

PubMed Central

Fischer, Anika; Zundler, Sebastian; Atreya, Raja; Rath, Timo; Voskens, Caroline; Hirschmann, Simon; López-Posadas, Rocío; Watson, Alastair; Becker, Christoph; Schuler, Gerold; Neufert, Clemens; Atreya, Imke; Neurath, Markus F

2016-01-01

Objective Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15. Design We assessed the expression of homing receptors on T cells in peripheral blood and inflamed mucosa. We studied the migration pattern and homing of Teff and Treg cells to the inflamed gut using intravital confocal microscopy and FACS in a humanised mouse model in dextran sodium sulfate-treated NSG (NOD.Cg-Prkdcscid-Il2rgtm1Wjl/SzJ) mice. Results Expression of GPR15 and α4β7 was significantly increased on Treg rather than Teff cells in peripheral blood of patients with UC as compared with Crohn’s disease and controls. In vivo analysis in a humanised mouse model showed augmented gut homing of UC Treg cells as compared with controls. Moreover, suppression of UC (but not control) Teff and Treg cell homing was noted upon treatment with the α4β7 antibody vedolizumab. In contrast, siRNA blockade of GPR15 had only effects on homing of Teff cells but did not affect Treg homing in UC. Clinical vedolizumab treatment was associated with marked expansion of UC Treg cells in peripheral blood. Conclusions α4β7 rather than GPR15 is crucial for increased colonic homing of UC Treg cells in vivo, while both receptors control UC Teff cell homing. Vedolizumab treatment impairs homing of UC Treg cells leading to their accumulation in peripheral blood with subsequent suppression of systemic Teff cell expansion. PMID:26209553

A change in temperature modulates defence to yellow (stripe) rust in wheat line UC1041 independently of resistance gene Yr36.

PubMed

Bryant, Ruth R M; McGrann, Graham R D; Mitchell, Alice R; Schoonbeek, Henk-Jan; Boyd, Lesley A; Uauy, Cristobal; Dorling, Steve; Ridout, Christopher J

2014-01-08

Rust diseases are of major importance in wheat production worldwide. With the constant evolution of new rust strains and their adaptation to higher temperatures, consistent and durable disease resistance is a key challenge. Environmental conditions affect resistance gene performance, but the basis for this is poorly understood. Here we show that a change in day temperature affects wheat resistance to Puccinia striiformis f. sp tritici (Pst), the causal agent of yellow (or stripe) rust. Using adult plants of near-isogenic lines UC1041 +/- Yr36, there was no significant difference between Pst percentage uredia coverage in plants grown at day temperatures of 18°C or 25°C in adult UC1041 + Yr36 plants. However, when plants were transferred to the lower day temperature at the time of Pst inoculation, infection increased up to two fold. Interestingly, this response was independent of Yr36, which has previously been reported as a temperature-responsive resistance gene as Pst development in adult UC1041 -Yr36 plants was similarly affected by the plants experiencing a temperature reduction. In addition, UC1041 -Yr36 plants grown at the lower temperature then transferred to the higher temperature were effectively resistant and a temperature change in either direction was shown to affect Pst development up to 8 days prior to inoculation. Results for seedlings were similar, but more variable compared to adult plants. Enhanced resistance to Pst was observed in seedlings of UC1041 and the cultivar Shamrock when transferred to the higher temperature. Resistance was not affected in seedlings of cultivar Solstice by a temperature change in either direction. Yr36 is effective at 18°C, refining the lower range of temperature at which resistance against Pst is conferred compared to previous studies. Results reveal previously uncharacterised defence temperature sensitivity in the UC1041 background which is caused by a change in temperature and independently of Yr36. This novel

Theoretical Model for Volume Fraction of UC, 235U Enrichment, and Effective Density of Final U 10Mo Alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devaraj, Arun; Prabhakaran, Ramprashad; Joshi, Vineet V.

2016-04-12

The purpose of this document is to provide a theoretical framework for (1) estimating uranium carbide (UC) volume fraction in a final alloy of uranium with 10 weight percent molybdenum (U-10Mo) as a function of final alloy carbon concentration, and (2) estimating effective 235U enrichment in the U-10Mo matrix after accounting for loss of 235U in forming UC. This report will also serve as a theoretical baseline for effective density of as-cast low-enriched U-10Mo alloy. Therefore, this report will serve as the baseline for quality control of final alloy carbon content

Observations of the photodissociated HI region that surrounds G213.880-11.837

NASA Astrophysics Data System (ADS)

Rodríguez-Rico, C. A.; Gómez, Y.; Garay, G.; Neria, C.; Rodríguez, L. F.; Escalante, V.; Lizano, S.; Lebrón, M.

2011-10-01

New observations of the HI 21 cm line toward the cometary HII region G213.880-11.837 are presented. These observations, carried out with an angular resolution of 15'', reveal that the neutral gas in this region is part of an expanding flow. The analysis of the kinematics of the HI gas suggests that the HI gas is undergoing a champagne flow: based on the difference between the radial velocities of the neutral gas in the tail ( 4km s^{-1}) compared to the velocities of the ambient molecular gas ( 11.5 km s^{-1}) and the asymmetry of the HI emission. Besides this photodissociated region, there is only one other reported following an HI champagne flow (G111.61+0.37).

Molecular structure of uranium carbides: Isomers of UC3

NASA Astrophysics Data System (ADS)

Zalazar, M. Fernanda; Rayón, Víctor M.; Largo, Antonio

2013-03-01

In this article, the most relevant isomers of uranium tricarbide are studied through quantum chemical methods. It is found that the most stable isomer has a fan geometry in which the uranium atom is bonded to a quasilinear C3 unit. Both, a rhombic and a ring CU(C2) structures are found about 104-125 kJ/mol higher in energy. Other possible isomers including linear geometries are located even higher. For each structure, we provide predictions for those molecular properties (vibrational frequencies, IR intensities, dipole moments) that could eventually help in their experimental detection. We also discuss the possible routes for the formation of the different UC3 isomers as well as the bonding situation by means of a topological analysis of the electron density.

Molecular structure of uranium carbides: isomers of UC3.

PubMed

Zalazar, M Fernanda; Rayón, Víctor M; Largo, Antonio

2013-03-21

In this article, the most relevant isomers of uranium tricarbide are studied through quantum chemical methods. It is found that the most stable isomer has a fan geometry in which the uranium atom is bonded to a quasilinear C3 unit. Both, a rhombic and a ring CU(C2) structures are found about 104-125 kJ/mol higher in energy. Other possible isomers including linear geometries are located even higher. For each structure, we provide predictions for those molecular properties (vibrational frequencies, IR intensities, dipole moments) that could eventually help in their experimental detection. We also discuss the possible routes for the formation of the different UC3 isomers as well as the bonding situation by means of a topological analysis of the electron density.

The Impact Of Galactic Environment On Star Formation

NASA Astrophysics Data System (ADS)

Kreckel, Kathryn

2016-09-01

While spiral arms are the most prominent sites for star formation in disk galaxies, interarm star formation contributes significantly to the overall star formation budget. However, it is still an open question if the star formation proceeds differently in the arm and inter-arm environment. We use deep VLT/MUSE optical IFU spectroscopy to resolve and fully characterize the physical properties of 428 interarm and arm HII regions in the nearby grand design spiral galaxy NGC 628. Unlike molecular clouds (the fuel for star formation) which exhibit a clear dependence on galactic environment, we find that most HII region properties (luminosity, size, metallicity, ionization parameter) are independent of environment. One clear exception is the diffuse ionized gas (DIG) contribution to the arm and interarm flux (traced via the temperature sensitive [SII]/Halpha line ratio inside and outside of the HII region boundaries). We find a systematically higher DIG background within HII regions, particularly on the spiral arms. Correcting for this DIG contamination can result in significant (70%) changes to the star formation rate measured. We also show preliminary results comparing well@corrected star formation rates from our MUSE HII regions to ALMA CO(2-1) molecular gas observations at matched 1"=35pc resolution, tracing the Kennicutt-Schmidt star formation law at the scales relevant to the physics of star formation. We estimate the timescales relevant for GMC evolution using distance from the spiral arm as a proxy for age, and test whether star formation feedback or galactic@scale dynamical processes dominate GMC disruption.

The impact of galactic environment on star formation

NASA Astrophysics Data System (ADS)

Kreckel, Kathryn; Blanc, Guillermo A.; Schinnerer, Eva; Groves, Brent; Adamo, Angela; Hughes, Annie; Meidt, Sharon; SFNG Collaboration

2017-01-01

While spiral arms are the most prominent sites for star formation in disk galaxies, interarm star formation contributes significantly to the overall star formation budget. However, it is still an open question if the star formation proceeds differently in the arm and inter-arm environment. We use deep VLT/MUSE optical IFU spectroscopy to resolve and fully characterize the physical properties of 428 interarm and arm HII regions in the nearby grand design spiral galaxy NGC 628. Unlike molecular clouds (the fuel for star formation) which exhibit a clear dependence on galactic environment, we find that most HII region properties (luminosity, size, metallicity, ionization parameter) are independent of environment. One clear exception is the diffuse ionized gas (DIG) contribution to the arm and interarm flux (traced via the temperature sensitive [SII]/Halpha line ratio inside and outside of the HII region boundaries). We find a systematically higher DIG background within HII regions, particularly on the spiral arms. Correcting for this DIG contamination can result in significant (70%) changes to the star formation rate measured. We also show preliminary results comparing well-corrected star formation rates from our MUSE HII regions to ALMA CO(2-1) molecular gas observations at matched 1"=50pc resolution, tracing the Kennicutt-Schmidt star formation law at the scales relevant to the physics of star formation. We estimate the timescales relevant for GMC evolution using distance from the spiral arm as a proxy for age, and test whether star formation feedback or galactic-scale dynamical processes dominate GMC disruption.

LncRNA uc.48+ is involved in the diabetic immune and inflammatory responses mediated by P2X7 receptor in RAW264.7 macrophages.

PubMed

Wu, Hong; Wen, Fang; Jiang, Mei; Liu, Qiang; Nie, Yijun

2018-08-01

High glucose combined with high FFAs can contribute to the unfavorable development of type 2 diabetes mellitus (T2DM) and monocytes/macrophages are important in the occurrence and development of T2DM, which is regarded as a type of low‑grade inflammation. Although our previous study demonstrated that increased expression of P2X7 receptor (P2X7R) in peripheral blood monocytes may alter the innate immune system and that long non‑coding (lnc)RNA uc.48+ was involved in diabetic neuropathic pain, the involvement of uc.48+ mediated by the P2X7R in monocyte/macrophages during T2DM has not been reported. In the present study, the effectsof uc.48+ small interference RNA (siRNA) on factors, including the mRNA and protein expression of P2X7R, apoptosis and proliferation, levels of reactive oxygen species (ROS), cytokine levels, and expression of phosphorylated (p‑) extracellular signal‑regulated kinase (ERK)1/2, were examined in RAW264.7 macrophages following exposure to high glucose and high plasma free fatty acids (FFAs). After RAW264.7 cells were transfected with uc.48+ siRNA under high glucose conditions and FFAs treatment, the mRNA expression levels of uc.48+ and P2X7 receptor were detected by reverse transcription‑polymerase chain reaction. The protein mass of P2X7 receptor and ERK signaling pathway were assessed by western blotting. ROS and calcium concentrations, and culture supernatant cytokine content [tumor necrosis factor‑α, interleukin (IL)‑10, IL‑1β] were detected by fluorescent probes and ELISA respectively. Cell viability and apoptosis were determined by MTS test and flow cytometry, respectively. It was found that treatment of RAW264.7 cells with high glucose and FFAs, which exhibited increased expression of uc.48+, evoked P2X7R‑mediated immune and inflammatory responses through several means, including cytokine secretion, ROS formation, and activation of the ERK signaling pathway. The uc.48+ siRNA regulated these factors and thus

UCS Protein Rng3p Is Essential for Myosin-II Motor Activity during Cytokinesis in Fission Yeast

PubMed Central

Stark, Benjamin C.; James, Michael L.; Pollard, Luther W.; Sirotkin, Vladimir; Lord, Matthew

2013-01-01

UCS proteins have been proposed to operate as co-chaperones that work with Hsp90 in the de novo folding of myosin motors. The fission yeast UCS protein Rng3p is essential for actomyosin ring assembly and cytokinesis. Here we investigated the role of Rng3p in fission yeast myosin-II (Myo2p) motor activity. Myo2p isolated from an arrested rng3-65 mutant was capable of binding actin, yet lacked stability and activity based on its expression levels and inactivity in ATPase and actin filament gliding assays. Myo2p isolated from a myo2-E1 mutant (a mutant hyper-sensitive to perturbation of Rng3p function) showed similar behavior in the same assays and exhibited an altered motor conformation based on limited proteolysis experiments. We propose that Rng3p is not required for the folding of motors per se, but instead works to ensure the activity of intrinsically unstable myosin-II motors. Rng3p is specific to conventional myosin-II and the actomyosin ring, and is not required for unconventional myosin motor function at other actin structures. However, artificial destabilization of myosin-I motors at endocytic actin patches (using a myo1-E1 mutant) led to recruitment of Rng3p to patches. Thus, while Rng3p is specific to myosin-II, UCS proteins are adaptable and can respond to changes in the stability of other myosin motors. PMID:24244528

From Luminous Hot Stars to Starburst Galaxies

NASA Astrophysics Data System (ADS)

Conti, Peter S.; Crowther, Paul A.; Leitherer, Claus

2012-10-01

1. Introduction; 2. Observed properties; 3. Stellar atmospheres; 4. Stellar winds; 5. Evolution of single stars; 6. Binaries; 7. Birth of massive stars and star clusters; 8. The interstellar environment; 9. From giant HII regions to HII galaxies; 10. Starburst phenomena; 11. Cosmological implications; References; Index.

Follow the Money: Engineering at Stanford and UC Berkeley during the Rise of Silicon Valley

ERIC Educational Resources Information Center

Adams, Stephen B.

2009-01-01

A comparison of the engineering schools at UC Berkeley and Stanford during the 1940s and 1950s shows that having an excellent academic program is necessary but not sufficient to make a university entrepreneurial (an engine of economic development). Key factors that made Stanford more entrepreneurial than Cal during this period were superior…

Development of X-ray computed tomography inspection facility for the H-II solid rocket boosters

NASA Astrophysics Data System (ADS)

Sasaki, M.; Fujita, T.; Fukushima, Y.; Shimizu, M.; Itoh, S.; Satoh, A.; Miyamoto, H.

The National Space Development Agency of Japan (NASDA) initiated the development of an X-ray computed tomography (CT) equipment for the H-II solid rocket boosters (SRBs) in 1987 for the purpose of minimizing inspection time and achieving high cost-effectiveness. The CT facility has been completed in Jan. 1991 in Tanegashima Space Center for the inspection of the SRBs transported from the manufacturer's factory to the launch site. It was first applied to the qualification model SRB from Feb. to Apr. in 1991. Through the CT inspection of the SRB, it has been confirmed that inspection time decreased significantly compared with the X-ray radiography method and that even an unskilled inspector could find various defects. As a result, the establishment of a new reliable inspection method for the SRB has been verified. In this paper, the following are discussed: (1) the defect detectability of the CT equipment using a dummy SRB with various artificial defects, (2) the performance comparison between the CT method and the X-ray radiography method, (3) the reliability of the CT equipment, and (4) the radiation shield design of the nondestructive test building.

Cloning and Characterization of the Pyrrolomycin Biosynthetic Gene Clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. Strain UC 11065▿

PubMed Central

Zhang, Xiujun; Parry, Ronald J.

2007-01-01

The pyrrolomycins are a family of polyketide antibiotics, some of which contain a nitro group. To gain insight into the nitration mechanism associated with the formation of these antibiotics, the pyrrolomycin biosynthetic gene cluster from Actinosporangium vitaminophilum was cloned. Sequencing of ca. 56 kb of A. vitaminophilum DNA revealed 35 open reading frames (ORFs). Sequence analysis revealed a clear relationship between some of these ORFs and the biosynthetic gene cluster for pyoluteorin, a structurally related antibiotic. Since a gene transfer system could not be devised for A. vitaminophilum, additional proof for the identity of the cloned gene cluster was sought by cloning the pyrrolomycin gene cluster from Streptomyces sp. strain UC 11065, a transformable pyrrolomycin producer. Sequencing of ca. 26 kb of UC 11065 DNA revealed the presence of 17 ORFs, 15 of which exhibit strong similarity to ORFs in the A. vitaminophilum cluster as well as a nearly identical organization. Single-crossover disruption of two genes in the UC 11065 cluster abolished pyrrolomycin production in both cases. These results confirm that the genetic locus cloned from UC 11065 is essential for pyrrolomycin production, and they also confirm that the highly similar locus in A. vitaminophilum encodes pyrrolomycin biosynthetic genes. Sequence analysis revealed that both clusters contain genes encoding the two components of an assimilatory nitrate reductase. This finding suggests that nitrite is required for the formation of the nitrated pyrrolomycins. However, sequence analysis did not provide additional insights into the nitration process, suggesting the operation of a novel nitration mechanism. PMID:17158935

Spitzer Observations of M33 & M83 and the Hot Star, Hii Region Connection

NASA Astrophysics Data System (ADS)

Rubin, R.; Simpson, J.; Colgan, S.; Dufour, R.; Citron, R.; Ray, K.; Erickson, E.; Haas, M.; Pauldrach, A.

2007-05-01

H II regions play a crucial role in the measurement of current interstellar abundances. They also serve as laboratories for atomic physics and provide fundamental data about heavy element abundances that serve to constrain models of galactic chemical evolution. We observed emission lines of [S IV] 10.5, H (7-6) 12.4, [Ne II] 12.8, [Ne III] 15.6, & [S III] 18.7 micron cospatially with the Spitzer Space Telescope using the Infrared Spectrograph (IRS) in short-high mode (SH). Here we concentrate on the galaxy M33 and compare the results with our earlier similar study of M83. In each of these substantially face-on spirals, we observed ˜25 H II regions, covering a full range of galactocentric radii (RG). For most of the M33 H II regions, we were able to measure the H (7-6) line while none were detectable in M83. This limited our M83 study to a determination of the Ne++/Ne+, /, and S3+/S++ abundance ratios vs. RG. Angular brackets denote fractional ionizations. As well as having the addition of fluxes for the H(7-6) line, the M33 H II regions are generally of much higher ionization than those in M83, resulting in larger Ne++/Ne+ and S3+/ S++ abundance ratios. For M33, in addition to what we derived for those nebulae in M83, we are also able to derive Ne/H, S/H and Ne/S vs. RG. Important advantages compared with prior optical studies are: 1) the IR lines have a weak and similar electron temperature (Te) dependence while optical lines vary exponentially with Te and 2) the IR lines suffer far less from interstellar extinction. Additionally, these data may be used as constraints on the ionizing spectral energy distribution for the stars exciting these nebulae by comparing the above ionic ratios with predictions using stellar atmosphere models from several different non-LTE model sets. This work is based on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under NASA contract

Recent Changes in UC Admissions Policies. Parent/Student Guide = Unos cambios recientes en los reglamentos de ingreso de la universidad de California. Guia de padres/estudiantes.

ERIC Educational Resources Information Center

EdSource, Inc., Palo Alto, CA.

This parent/student guide describes recent changes in admissions policies at the University of California (UC). Traditionally, UC admitted the top 12.5% of high school graduating seniors, but beginning in 2001, the top 4% of students in the graduating class of every high school are eligible if they have completed 11 specific "a-f"…

Whole-Blood Thiopurine S-Methyltransferase Genotype and Phenotype Concordance in Iranian Kurdish Ulcerative Colitis (UC) Patients.

PubMed

Bahrehmand, Fariborz; Vaisi-Raygani, Asad; Kiani, Amir; Bashiri, Homayoun; Zobeiri, Mahdi; Tanhapour, Maryam; Pourmotabbed, Tayebeh

2017-05-01

Thiopurine methyl transferase (TPMT), a drug-metabolizing enzyme, catalyzes methylation and consequently, the metabolism of thiopurine compounds used for treatment of inflammatory bowel disease (IBD). Individuals who are homozygous recessive or have extremely low TPMT activity need to avoid thiopurines because of concern for significant leukopenia. The aim of this research was to determine TPMT phenotypes and genotypes in IBD patients to predict the risk of thiopurine toxicity before treatment. The present case-control study consisted of 210 ulcerative colitis patients and 212 unrelated healthy controls from the population of western Iran. TPMT phenotype and genotype were determined by HPLC and allele specific PCR and PCR-RFLP, respectively. TPMT phenotyping and genotyping were compatible and demonstrated no frequency for deficient, 2.2% for low, and 97.8% for normal-activity which is different compared with the results of other studies. There was a significant negative correlation between TPMT activities as calculated based on nmol6MTG/gHb/h and the Hb levels in both UC (r = -0.54, p < 0.001) and control groups (r = -0.27, p < 0.001). Interestingly, a significant positive correlation between Hb levels and TPMT activities was seen when the enzyme activity was calculated in mU/L in both UC patients (r = 0.14, p = 0.05) and in control subjects (r = 0.43, p < 0.001). The overall concordance rate between TPMT phenotypes and genotypes of mutants to alleles (9 out of 422), based on receiver-operating characteristic (ROC) curve, yielded a sensitivity of 94.7% and specificity of 90% for mU/L and a sensitivity of 85.6% and specificity of 90% for nmol6MTG/gHb/h. The use of mU/L is more appropriate than nmol6MTG/gHb/h for expressing TPMT activity, and there is better correlation between genotypes and phenotypes of TPMT based on mU/L. The frequency of known mutant TPMT alleles in western Iran (Kurd population) is low suggesting low risk of thiopurine drug toxicity in IBD

VizieR Online Data Catalog: Infrared morphology of HII regions (Topchieva+, 2017)

NASA Astrophysics Data System (ADS)

Topchieva, A. P.; Wiebe, D. S.; Kirsanova, M. S.; Krushinskii, V. V.

2018-03-01

The 20-cm New GPS survey (http://third.ucllnl.org/gps), created using the MAGPIS database of radio images of regions with Galactic coordinates |bGal|<0.8° and 5°

Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study.

PubMed

Reinisch, Walter; Panés, Julián; Khurana, Sunil; Toth, Gabor; Hua, Fei; Comer, Gail M; Hinz, Michelle; Page, Karen; O'Toole, Margot; Moorehead, Tara McDonnell; Zhu, Hua; Sun, YanHui; Cataldi, Fabio

2015-06-01

Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody that inhibits human IL-13, was evaluated for the treatment of UC. In a multicentre, randomised, double-blind, placebo-controlled study, patients with active UC (Mayo score ≥4 and <10) were randomised to anrukinzumab 200, 400 or 600 mg or placebo. Patients received five intravenous administrations over 14 weeks. The primary endpoint was fold change from baseline in faecal calprotectin (FC) at Week 14. Secondary endpoints included safety, pharmacokinetics and IL-13 levels. The modified intention-to-treat population included 84 patients (21 patients/arm). Fold change of FC from baseline at Week 14 was not significantly different for any treatment groups compared with the placebo. The study had a high dropout rate, in part, related to lack of efficacy. The exploratory comparisons of each dose were not significantly different from placebo in terms of change from baseline in total Mayo score, clinical response, clinical remission and proportion of subjects with mucosal healing. An increase in serum total IL-13 (free and bound to anrukinzumab) was observed for all anrukinzumab groups but not with placebo. This suggests significant binding of anrukinzumab to IL-13. The safety profile was not different between the anrukinzumab and placebo groups. A statistically significant therapeutic effect of anrukinzumab could not be demonstrated in patients with active UC in spite of binding of anrukinzumab to IL-13. ClinicalTrials.gov number NCT01284062. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Placebo Response is Driven by UCS Revaluation: Evidence, Neurophysiological Consequences and a Quantitative Model

PubMed Central

Puviani, Luca; Rama, Sidita

2016-01-01

Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms, theoretical modeling of the placebo response remains poorly developed. The most extensively accepted theories are expectation and conditioning, involving both conscious and unconscious information processing. However, it is not completely understood how these mechanisms can shape the placebo response. We focus here on neural processes which can account for key properties of the response to substance intake. It is shown that placebo response can be conceptualized as a reaction of a distributed neural system within the central nervous system. Such a reaction represents an integrated component of the response to open substance administration (or to substance intake) and is updated through “unconditioned stimulus (UCS) revaluation learning”. The analysis leads to a theorem, which proves the existence of two distinct quantities coded within the brain, these are the expected or prediction outcome and the reactive response. We show that the reactive response is updated automatically by implicit revaluation learning, while the expected outcome can also be modulated through conscious information processing. Conceptualizing the response to substance intake in terms of UCS revaluation learning leads to the theoretical formulation of a potential neuropharmacological treatment for increasing unlimitedly the effectiveness of a given drug. PMID:27436417

Placebo Response is Driven by UCS Revaluation: Evidence, Neurophysiological Consequences and a Quantitative Model.

PubMed

Puviani, Luca; Rama, Sidita

2016-07-20

Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms, theoretical modeling of the placebo response remains poorly developed. The most extensively accepted theories are expectation and conditioning, involving both conscious and unconscious information processing. However, it is not completely understood how these mechanisms can shape the placebo response. We focus here on neural processes which can account for key properties of the response to substance intake. It is shown that placebo response can be conceptualized as a reaction of a distributed neural system within the central nervous system. Such a reaction represents an integrated component of the response to open substance administration (or to substance intake) and is updated through "unconditioned stimulus (UCS) revaluation learning". The analysis leads to a theorem, which proves the existence of two distinct quantities coded within the brain, these are the expected or prediction outcome and the reactive response. We show that the reactive response is updated automatically by implicit revaluation learning, while the expected outcome can also be modulated through conscious information processing. Conceptualizing the response to substance intake in terms of UCS revaluation learning leads to the theoretical formulation of a potential neuropharmacological treatment for increasing unlimitedly the effectiveness of a given drug.

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with "F-5" Gene.

PubMed

Leng, Xiangfeng; Fan, Yongle; Wang, Yating; Sun, Jian; Cai, Xia; Hu, Chunnan; Ding, Xiaoying; Hu, Xiaoying; Chen, Zhengyu

2017-06-06

BACKGROUND Recent studies have shown that skin flap transplantation technique plays an important role in surgical procedures. However, there are many problems in the process of skin flap transplantation surgeries, especially ischemia-reperfusion injury, which directly affects the survival rate of the skin flap and patient prognosis after surgeries. MATERIAL AND METHODS In this study, we used a new method of the "stem cells-gene" combination therapy. The "F-5" gene fragment of heat shock protein 90-α (Hsp90-α) was transfected into human umbilical cord mesenchymal stem cells (hUC-MSCs) by genetic engineering technique. RESULTS The synergistic effects of "F-5" gene and hUC-MSCs in the treatment of ischemia-reperfusion injury of the skin flap were confirmed by histochemical and immunohistochemical methods. CONCLUSIONS This study showed that the hUC-MSCs transfected with "F-5" gene can effectively improve the repair of ischemia-reperfusion injury.

Regional Integrated Assessments in Support of Decision-making: Process, Product, and Policy

NASA Astrophysics Data System (ADS)

Luers, A. L.; Hayhoe, K.

2006-12-01

Regional integrated climate assessments are increasingly viewed as critical for informing sound climate policy. Yet, the scientific information in many assessments often is not effectively transformed in to policies to protect the environment. Why are some assessments more effective at informing policies than others? We will provide some insight into this question by describing the lessons learned from a series of regional assessments organized by the Union of Concerned Scientists (UCS). Working with independent experts in the global change research community, UCS has produced assessments in three regions of the US California, the Great Lakes, and the Gulf Coast. The reports from each of these assessments continue to be used by local, state and regional decision-makers in related management and policy initiatives. We attribute the success of these assessments in motivating and supporting climate-related decisions to four factors: (1) credibility, attained both through scientific peer-review and by engaging local scientific and community leaders; (2) regional relevance of assessment focus areas; (3) accessible presentation of the results to non-technical audiences; and (4) wide communication and distribution of the report to the media, the public, civic groups, and public officials.

Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA).

PubMed

Bagi, C M; Berryman, E R; Teo, S; Lane, N E

2017-12-01

The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery 10 rats received vehicle and another 10 rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition 10 naïve rats were used as an intact control and another 10 rats received sham surgery. Study endpoints included a weight-bearing capacity of front and hind legs, serum biomarkers of bone and cartilage metabolism, analyses of subchondral and cancellous bone at the tibial epiphysis and metaphysis, and cartilage pathology at the medial tibial plateau using histological methods. PMMT surgery produced moderate OA at the medial tibial plateau. Specifically, the deterioration of articular cartilage negatively impacted the weight bearing capacity of the operated limb. Immediate treatment with the UC-II preserved the weight-bearing capacity of the injured leg, preserved integrity of the cancellous bone at tibial metaphysis and limited the excessive osteophyte formation and deterioration of articular cartilage. Study results demonstrate that a clinically relevant daily dose of UC-II when applied immediately after injury can improve the mechanical function of the injured knee and prevent excessive deterioration of articular cartilage. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Evolution of the X-ray luminosity in young HII galaxies

NASA Astrophysics Data System (ADS)

Rosa González, D.; Terlevich, E.; Jiménez Bailón, E.; Terlevich, R.; Ranalli, P.; Comastri, A.; Laird, E.; Nandra, K.

2009-10-01

In an effort to understand the correlation between X-ray emission and present star formation rate, we obtained XMM-Newton data to estimate the X-ray luminosities of a sample of actively star-forming HII galaxies. The obtained X-ray luminosities are compared to other well-known tracers of star formation activity such as the far-infrared and the ultraviolet luminosities. We also compare the obtained results with empirical laws from the literature and with recently published analysis applying synthesis models. We use the time delay between the formation of the stellar cluster and that of the first X-ray binaries, in order to put limits on the age of a given stellar burst. We conclude that the generation of soft X-rays, as well as the Hα or infrared luminosities is instantaneous. The relation between the observed radio and hard X-ray luminosities, on the other hand, points to the existence of a time delay between the formation of the stellar cluster and the explosion of the first massive stars and the consequent formation of supernova (SN) remnants and high-mass X-ray binaries, which originate the radio and hard X-ray fluxes, respectively. When comparing hard X-rays with a star formation indicator that traces the first million years of evolution (e.g. Hα luminosities), we found a deficit in the expected X-ray luminosity. This deficit is not found when the X-ray luminosities are compared with infrared luminosities, a star formation tracer that represents an average over the last 108yr. The results support the hypothesis that hard X-rays are originated in X-ray binaries which, as SN remnants, have a formation time delay of a few mega years after the star-forming burst. Partially based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and NASA. E-mail: danrosa@inaoep.mx ‡ Visiting Fellow, IoA, Cambridge, UK.

Far infrared spectroscopy of star formation regions in M82

NASA Technical Reports Server (NTRS)

Duffy, P. B.; Erickson, E. F.; Haas, M. R.; Houck, J. R.

1986-01-01

Emission lines of (O III) at 52 microns and 88 microns and of (N III) at 57 microns in the nucleus of the galaxy M82 have been observed from the Kuiper Airborne Observatory with the facility's cooled grating spectrometer. The (N III) line has not been previously detected in any extragalactic source. The fluxes in the lines indicate approx 4 x 10 to the 7th power M of ionized gas and a large population of massive stars (equivalent to 5 x 10 to the 5th power 08.5 stars), sufficient to power the infrared luminosity of the nucleus. We use the 52 to 88 micron line intensity ratio to find an average electron density of 210 + or 75 in the nucleus; this is 10 to 100 times lower than values typically observed in individual compact HII regions in our Galaxy. The relative line strengths of the (O III) and (N III) lines imply an N(++)/O(++) ratio of 0.45 + or - 0.1, significantly lower than is measured by the same method in individual HII regions at similar galactocentric distances (equal to or less than 400 pc) in our Galaxy. This lower N(++)/O(++) ratio may be due to a lower N/O ratio, higher stellar temperatures, or both, in M82. At spectral resolutions of approx. 90 km/s, all three line profiles are similarly asymmetric. They can be well fitted by two Gaussian distributions with widths of approx. 150 km/s and central velocities of approx. 110 and approx. 295 km/s, bracketing the systemic velocity of the nucleus of approx. 210 km/s. Within uncertainties, both the N(++)/O(++) ratio and the electron density are the same for both Gaussian components; this indicates no major large-scale gradient in either quantity within the nucleus.

Recruitment, Advancement and Retention of Women in the Physical Sciences at U.C. Irvine

NASA Astrophysics Data System (ADS)

Druffel, E. R.; Smecker-Hane, T.; Kehoe, P.; Bryant, S. V.

2004-12-01

Strategies for the recruitment, retention and advancement of women in the physical sciences at U.C. Irvine are presented. The NSF-funded ADVANCE Program has implemented several new initiatives. Among these are new requirements for recruitment committees, participation by school equity advisors, personalized mentoring programs and establishment of senior chairs. Progress towards our goals are reviewed and evaluated. Issues such as dual career couples and the balance between family/personal time and work are also addressed.

UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II

PubMed Central

Lord, Matthew; Pollard, Thomas D.

2004-01-01

We purified native Myo2p/Cdc4p/Rlc1p (Myo2), the myosin-II motor required for cytokinesis by Schizosaccharomyces pombe. The Myo2p heavy chain associates with two light chains, Cdc4p and Rlc1p. Although crude Myo2 supported gliding motility of actin filaments in vitro, purified Myo2 lacked this activity in spite of retaining full Ca-ATPase activity and partial actin-activated Mg-ATPase activity. Unc45-/Cro1p-/She4p-related (UCS) protein Rng3p restored the full motility and actin-activated Mg-ATPase activity of purified Myo2. The COOH-terminal UCS domain of Rng3p alone restored motility to pure Myo2. Thus, Rng3p contributes directly to the motility activity of native Myo2. Consistent with a role in Myo2 activation, Rng3p colocalizes with Myo2p in the cytokinetic contractile ring. The absence of Rlc1p or mutations in the Myo2p head or Rng3p compromise the in vitro motility of Myo2 and explain the defects in cytokinesis associated with some of these mutations. In contrast, Myo2 with certain temperature-sensitive forms of Cdc4p has normal motility, so these mutations compromise other functions of Cdc4p required for cytokinesis. PMID:15504913

C. Judson King of UC Berkeley

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prausnitz, John

2005-06-01

In the middle of the UC Berkeley campus, next to the Main Library, South Hall is the last surviving building from the original campus, founded about 135 years ago. A tiny tree-shaded appendix to this venerated classical building houses Berkeley's Center for Studies in Higher Education, directed by C. Judson King, former Provost and Senior Vice President--Academic Affairs of the ten-campus University of California and long-time Professor of Chemical Engineering at Berkeley. Jud came to Berkeley in 1963 as assistant professor of chemical engineering, following receipt of a doctor's degree from MIT and a subsequent short appointment as director ofmore » the MIT chemical engineering practice school station at what was then Esso (now Exxon) in New Jersey. His undergraduate degree is from Yale. Starting with his MIT doctoral dissertation on gas absorption, Jud has devoted much of his professional career to separation processes. His teaching and research activities have been primarily concerned with separation of mixtures with emphasis on liquid-liquid extraction and drying. As a consultant to Procter and Gamble, he contributed to the technology of making instant coffee. His life-long activities in hiking and camping stimulated Jud's interest in the manufacture of freeze-dried foods (e.g. turkey meat) to minimize the weight of his hiking back-pack. Jud is internationally known not only for his many research publications but even more, for his acclaimed textbook ''Separation Processses'' (McGraw-Hill, second edition 1980) that is used in standard chemical engineering courses in the US and abroad.« less

VLA HI Zeeman Observations of the Cygnus X Region: DR 22 And ON 2

NASA Astrophysics Data System (ADS)

Mayo, Elizabeth A.; Troland, T. H.

2010-01-01

The Very Large Array in Socorro, New Mexico has been used to study the Zeeman Effect in the 21cm HI line seen in absorption against radio sources in the Cygnus X region. Cygnus X is geometrically favorable for Zeeman effect observations as the region lies along the mean field direction of the diffuse interstellar medium (ISM) of the galaxy. We present observations of two compact HII regions within Cygnus X, DR 22 and ON 2. The data show magnetic field strengths of the order -80 μG toward DR 22 alone with no significant detections toward ON 2. This information is used to estimate the magnetic energy of the DR 22 star-forming cloud, and allows for a complete analysis of the energetics of the region revealing the role of the magnetic field. Support for this work was provided by the NSF PAARE program to South Carolina State University under award AST-0750814.

The Chicago Public Schools (CPS)/University of Chicago (UC) Internet Project (CUIP)

NASA Astrophysics Data System (ADS)

Richardson, D.; Rebull, L. M.; Munoz-Franco, L.; Jay, M. J.; Burke, R. D.; Fenstermacher, K. D.; Lenz, D. D.; MacNaught, H.; Marks, M. D.; Murphy, J.; Thomas, C.; York, D. G.; Anderson, D.; Chisom, Y.; Dynis, R.; Letts, J.; Lewis, E.; Harris, E.; Segneri, L.

1998-01-01

The Chicago Public Schools (CPS)/University of Chicago (UC) Internet Project (CUIP) is a collaborative pilot project among the UC, CPS Central Administration, and 24 public schools in the Woodlawn, Hyde Park/ South Kenwood, and North Kenwood/Oakland neighborhoods. Our primary goal is connecting these schools to the Internet, emphasizing the continued support of the schools and their teachers after the computers and connections are in place. We work with principals, department heads, and individual teachers to create and nurture a self-sustaining computer culture that will both maintain the network systems and incorporate the technology into the curriculum. We also encourage the schools to take advantage of ther new connectivity by collaborating and sharing resources among themselves. Formal interactions are fostered with museums and research centers, locally and nationally. CUIP is committed to supporting these schools as they use the Internet to enhance student learning. CUIP's goals include: providing T-1 internet connectivity to 24 local schools, supporting the technology coordinator in each school in order to ensure continuous Internet connectivity, and developing effective technology plans, including technology upgrades; nurturing and supporting teachers interested in incorporating technology in their classroom; fostering an environment in which the students can acquire a wide range of comptuer skills appropriate to the current job market; and fostering similar community-based efforts, around Chicago and the nation. CUIP's milestones include: internet service connected to 12 schools; technology interns placed in some CUIP schools in collaboration with Governors State University; email provided to more than half of the 660 teachers in connected schools; and World Wide Web for Teachers, a summer class on curriculum uses of the Web, taught by CUIP staff to 23 of over 100 public school teacher applicants.

Site Monitoring at the U.C. Observatory of Santa Martina

NASA Astrophysics Data System (ADS)

Gatica, C.; Vanzi, L.; Toledo, I.; Lombardi, G.

2011-11-01

This work presents an astroclimatologic analysis of the UC Santa Martina Observatory site. This site is located near Santiago at latitude 33.3°S, longitude 70.5°W and an altitude of 1492 meters above sea level. The analysis was performed using data of temperature, pressure, humidity, and wind collected with a Davis Net Vantage Pro 2 meteo station in a period from December 2007 to January 2011. We estimated average values for the parameters monitored on different time scales and examined daily as well as seasonal variations. We also estimated the downtime due to clouds average with an 37.23% of nights in 2010, humidity, wind over the period examined. The average relative humidity is 49%, wind is predominantly (24% of time) from southsouthwest with an average speed of 0.6 m/s. Finally, we describe Seeing measurements obtained with a DIMM monitor recently installed in the site.

Downregulation of viral RNA translation by hepatitis C virus non-structural protein NS5A requires the poly(U/UC) sequence in the 3' UTR.

PubMed

Hoffman, Brett; Li, Zhubing; Liu, Qiang

2015-08-01

Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is essential for viral replication; however, its effect on HCV RNA translation remains controversial partially due to the use of reporters lacking the 3' UTR, where NS5A binds to the poly(U/UC) sequence. We investigated the role of NS5A in HCV translation using a monocistronic RNA containing a Renilla luciferase gene flanked by the HCV UTRs. We found that NS5A downregulated viral RNA translation in a dose-dependent manner. This downregulation required both the 5' and 3' UTRs of HCV because substitution of either sequence with the 5' and 3' UTRs of enterovirus 71 or a cap structure at the 5' end eliminated the effects of NS5A on translation. Translation of the HCV genomic RNA was also downregulated by NS5A. The inhibition of HCV translation by NS5A required the poly(U/UC) sequence in the 3' UTR as NS5A did not affect translation when it was deleted. In addition, we showed that, whilst the amphipathic α-helix of NS5A has no effect on viral translation, the three domains of NS5A can inhibit translation independently, also dependent on the presence of the poly(U/UC) sequence in the 3' UTR. These results suggested that NS5A downregulated HCV RNA translation through a mechanism involving the poly(U/UC) sequence in the 3' UTR.

FIFI: The MPE Garching/UC Berkeley Far-Infrared Imaging Fabry-Perot Interferometer

NASA Technical Reports Server (NTRS)

Geis, Norbert; Genzel, Reinhard; Haggerty, M.; Herrmann, F.; Jackson, J.; Madden, Suzanne C.; Nikola, T.; Poglitsch, Albrecht; Rumitz, M.; Stacey, G. J.

1995-01-01

We describe the performance characteristics of the MPE Garching/UC Berkeley Far-Infrared Imaging Fabry-Perot Interferometer (FIFI) for the Kuiper Airborne Observatory (KAO). The spectrometer features two or three cryogenic tunable Fabry-Perot filters in series giving spectral resolution R of up to 10(exp 5) in the range of 40 microns less than lambda less than 200 microns, and an imaging 5x5 array of photoconductive detectors with variable focal plane plate scale. The instrument works at background limited sensitivity of up to 2 x 10(exp -19) W cm(exp -2) Hz(exp -1/2) per pixel per resolution element at R = 10(exp 5) on the KAO.

Fotometria WHBY |o lll|/HB de Regiones H 11 Y la HISTORIA de la Formacion ESTELAR Reciente EN la PEQUENA NUBE de Magallanes

NASA Astrophysics Data System (ADS)

Copetti, M. V. F.; Dottori, H. A.

1987-05-01

El ancho equivalente WHβ de la linea de Hβ en emisión y la razón [0 III]/Hβ del par λλ4959, 50 7 A del [0111], fueron medidos en 23 regiones HII de la Peque˜a Nube de Magallanes, por medio de la fotometría fotoeléctrica a través de un sistema de tres filtros interferenciales: dos Hβ , con bandas pasantes de 100 y 30 A, y un [0111] centrado en 5000 A y con banda pasante de 50 A. Las observaciones fueron realizadas con los telescopios de 1.60-m y 0.60-m del Laboratorio Nacional de Astrofísica, Brasópolis, Brasil. Fueron escogidos diafragmas suficientemente grandes para captar la radiación integrada de cada región HII. Las medidas fueron calibradas por comparación a un conjunto de nebulosas planetarias con flujos absolutos bien definidos. A través de la comparación entre los datos observacionales y modelos evolutivos de WHβ y [0 III] /Hβ (Copetti et al.1986', Astr. and Ap., 156, 111), las edades de las regiones HIl fueron estimadas. Basada en la distribución espacial de las edades de regiones HIl, la historia de la formación estelar reciente en la Pequeña Nube de Magallanes es analizada. La similitud de las medidas de WH&beta y [OIII]/WHβ entre las regiones H II observadas sugiere que hubo una explosión de formación estelar a 4±1 x106 años en la Pequeña Nube de Magallanes. (Parcialmente financiado por CNPq).

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with “F-5” Gene

PubMed Central

Leng, Xiangfeng; Fan, Yongle; Wang, Yating; Sun, Jian; Cai, Xia; Hu, Chunnan; Ding, Xiaoying; Hu, Xiaoying; Chen, Zhenyu

2017-01-01

Background Recent studies have shown that skin flap transplantation technique plays an important role in surgical procedures. However, there are many problems in the process of skin flap transplantation surgeries, especially ischemia-reperfusion injury, which directly affects the survival rate of the skin flap and patient prognosis after surgeries. Material/Methods In this study, we used a new method of the “stem cells-gene” combination therapy. The “F-5” gene fragment of heat shock protein 90-α (Hsp90-α) was transfected into human umbilical cord mesenchymal stem cells (hUC-MSCs) by genetic engineering technique. Results The synergistic effects of “F-5” gene and hUC-MSCs in the treatment of ischemia-reperfusion injury of the skin flap were confirmed by histochemical and immunohistochemical methods. Conclusions This study showed that the hUC-MSCs transfected with “F-5” gene can effectively improve the repair of ischemia-reperfusion injury. PMID:28586321

Chemical Abundances and Physical Parameters of H II Regions in the Magellanic Clouds

NASA Astrophysics Data System (ADS)

Reyes, R. E. C.

The chemical abundances and physical parameters of H II regions are important pa rameters to determine in order to understand how stars and galaxies evolve. The Magellanic Clouds offer us a unique oportunity to persue such studies in low metallicity galaxies. In this contribution we present the results of the photoionization modeling of 5 H II regions in each of the Large Magellanic Cloud (LMC) and Small Magellanic Cloud (SMC) sys tems. Optical data were collected from the literature, complemented by our own observa tions (Carlos Reyes et al. 1998), including UV spectra from the new IUE data ban k and infrared fluxes from the IRAS satellite. The chemical abundances of He, C, N, O, Ne, S, Ar and physical parameters like the densities, the ionized masses, the luminosities, the ionization temperatures , the filling factor and optical depth are determined. A comparison of the abundances of these HII regions with those of typical planetary nebulae and supergiants stars is also presented.

Biofilm Formation on Stainless Steel by Streptococcus thermophilus UC8547 in Milk Environments Is Mediated by the Proteinase PrtS.

PubMed

Bassi, D; Cappa, F; Gazzola, S; Orrù, L; Cocconcelli, P S

2017-04-15

In Streptococcus thermophilus , gene transfer events and loss of ancestral traits over the years contribute to its high level of adaptation to milk environments. Biofilm formation capacity, a phenotype that is lost in the majority of strains, plays a role in persistence in dairy environments, such as milk pasteurization and cheese manufacturing plants. To investigate this property, we have studied S. thermophilus UC8547, a fast-acidifying dairy starter culture selected for its high capacity to form biofilm on stainless steel under environmental conditions resembling the dairy environment. Using a dynamic flow cell apparatus, it was shown that S. thermophilus UC8547 biofilm formation on stainless steel depends on the presence of milk proteins. From this strain, which harbors the prtS gene for the cell wall protease and shows an aggregative phenotype, spontaneous mutants with impaired biofilm capacity can be isolated at high frequency. These mutants lack the PrtS expendable island, as confirmed by comparison of the genome sequence of UC8547Δ3 with that of the parent strain. The prtS island excision occurs between two 26-bp direct repeats located in the two copies of the IS Sth1 flanking this genomic island. The central role of PrtS was confirmed by analyzing the derivative strain UC8547Δ16, whose prtS gene was interrupted by an insertional mutation, thereby making it incapable of biofilm formation. PrtS, acting as a binding substance between the milk proteins adhered to stainless steel and S. thermophilus cell envelopes, mediates biofilm formation in dairy environments. This feature provides S. thermophilus with an ecological benefit for its survival and persistence in this environment. IMPORTANCE The increased persistence of S. thermophilus biofilm has consequences in the dairy environment: if, on the one hand, the release of this microorganism from biofilm can promote the fermentation of artisanal cheeses, under industrial conditions it may lead to undesirable

Biofilm Formation on Stainless Steel by Streptococcus thermophilus UC8547 in Milk Environments Is Mediated by the Proteinase PrtS

PubMed Central

Cappa, F.; Gazzola, S.; Orrù, L.

2017-01-01

ABSTRACT In Streptococcus thermophilus, gene transfer events and loss of ancestral traits over the years contribute to its high level of adaptation to milk environments. Biofilm formation capacity, a phenotype that is lost in the majority of strains, plays a role in persistence in dairy environments, such as milk pasteurization and cheese manufacturing plants. To investigate this property, we have studied S. thermophilus UC8547, a fast-acidifying dairy starter culture selected for its high capacity to form biofilm on stainless steel under environmental conditions resembling the dairy environment. Using a dynamic flow cell apparatus, it was shown that S. thermophilus UC8547 biofilm formation on stainless steel depends on the presence of milk proteins. From this strain, which harbors the prtS gene for the cell wall protease and shows an aggregative phenotype, spontaneous mutants with impaired biofilm capacity can be isolated at high frequency. These mutants lack the PrtS expendable island, as confirmed by comparison of the genome sequence of UC8547Δ3 with that of the parent strain. The prtS island excision occurs between two 26-bp direct repeats located in the two copies of the ISSth1 flanking this genomic island. The central role of PrtS was confirmed by analyzing the derivative strain UC8547Δ16, whose prtS gene was interrupted by an insertional mutation, thereby making it incapable of biofilm formation. PrtS, acting as a binding substance between the milk proteins adhered to stainless steel and S. thermophilus cell envelopes, mediates biofilm formation in dairy environments. This feature provides S. thermophilus with an ecological benefit for its survival and persistence in this environment. IMPORTANCE The increased persistence of S. thermophilus biofilm has consequences in the dairy environment: if, on the one hand, the release of this microorganism from biofilm can promote the fermentation of artisanal cheeses, under industrial conditions it may lead to

Hydrophobic nanoparticles promote lamellar to inverted hexagonal transition in phospholipid mesophases.

PubMed

Bulpett, Jennifer M; Snow, Tim; Quignon, Benoit; Beddoes, Charlotte M; Tang, T-Y D; Mann, Stephen; Shebanova, Olga; Pizzey, Claire L; Terrill, Nicholas J; Davis, Sean A; Briscoe, Wuge H

2015-12-07

This study focuses on how the mesophase transition behaviour of the phospholipid dioleoyl phosphatidylethanolamine (DOPE) is altered by the presence of 10 nm hydrophobic and 14 nm hydrophilic silica nanoparticles (NPs) at different concentrations. The lamellar to inverted hexagonal phase transition (Lα-HII) of phospholipids is energetically analogous to the membrane fusion process, therefore understanding the Lα-HII transition with nanoparticulate additives is relevant to how membrane fusion may be affected by these additives, in this case the silica NPs. The overriding observation is that the HII/Lα boundaries in the DOPE p-T phase diagram were shifted by the presence of NPs: the hydrophobic NPs enlarged the HII phase region and thus encouraged the inverted hexagonal (HII) phase to occur at lower temperatures, whilst hydrophilic NPs appeared to stabilise the Lα phase region. This effect was also NP-concentration dependent, with a more pronounced effect for higher concentration of the hydrophobic NPs, but the trend was less clear cut for the hydrophilic NPs. There was no evidence that the NPs were intercalated into the mesophases, and as such it was likely that they might have undergone microphase separation and resided at the mesophase domain boundaries. Whilst the loci and exact roles of the NPs invite further investigation, we tentatively discuss these results in terms of both the surface chemistry of the NPs and the effect of their curvature on the elastic bending energy considerations during the mesophase transition.

LncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats mediated by P2X7 receptor in SCG.

PubMed

Wu, Bing; Zhang, Chunping; Zou, Lifang; Ma, Yucheng; Huang, Kangyu; Lv, Qiulan; Zhang, Xi; Wang, Shouyu; Xue, Yun; Yi, Zhihua; Jia, Tianyu; Zhao, Shanhong; Liu, Shuangmei; Xu, Hong; Li, Guilin; Liang, Shangdong

2016-05-01

Diabetic autonomic neuropathy includes the sympathetic ganglionic dysfunction. P2X7 receptor in superior cervical ganglia (SCG) participated in the pathological changes of cardiac dysfunction. Abnormal expression of long noncoding RNAs (lncRNAs) was reported to be involved in nervous system diseases. Our preliminary results obtained from rat lncRNA array profiling revealed that the expression of the uc.48+ was significantly increased in the rat SCG in response to diabetic sympathetic pathology. In this study, we found that lncRNAuc.48+ and P2X7 receptor in the SCG were increased in type 2 diabetic rats and were associated with the cardiac dysfunction. The uc.48+ small interference RNA (siRNA) improved the cardiac autonomic dysfunction and decreased the up-regulation P2X7 and the ratio of phosphorylated extracellular regulated protein kinases1/2 (p-ERK1/2) to ERK1/2 in SCG of type 2 diabetic rats. In conclusion, lncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats through regulating the expression of P2X7 and ERK signaling in SCG. Copyright © 2016 Elsevier B.V. All rights reserved.

Former University of California Chancellors Urge New Funding Models for UC. Research & Occasional Paper Series: CSHE.15.11

ERIC Educational Resources Information Center

Center for Studies in Higher Education, 2011

2011-01-01

In this era of massive budget cuts, the survival of the University of California as a great institution of learning has become the subject of increasingly urgent debate. Twenty-two of the twenty-nine living former UC chancellors met in San Francisco on June 26-28, 2011 to discuss the current threats facing the University and all of California…

Location of WR stars in NGC 6744

NASA Astrophysics Data System (ADS)

Bibby, Joanne; Crowther, Paul; Sandford, Emily

2013-06-01

Following our recent survey of Wolf-Rayet (WR) stars in NGC 6744 we present a preliminary investigation into the location of these stars. Using high spatial resolution Hα images we find that the majority of WR stars are associated with nebular emission, albeit faint in many cases. We can use this HII association to constrain the lifetime and mass of the WR star since HII regions are such short-lived.

Development of telescope control system for the 50cm telescope of UC Observatory Santa Martina

NASA Astrophysics Data System (ADS)

Shen, Tzu-Chiang; Soto, Ruben; Reveco, Johnny; Vanzi, Leonardo; Fernández, Jose M.; Escarate, Pedro; Suc, Vincent

2012-09-01

The main telescope of the UC Observatory Santa Martina is a 50cm optical telescope donated by ESO to Pontificia Universidad Catolica de Chile. During the past years the telescope has been refurbished and used as the main facility for testing and validating new instruments under construction by the center of Astro-Engineering UC. As part of this work, the need to develop a more efficient and flexible control system arises. The new distributed control system has been developed on top of Internet Communication Engine (ICE), a framework developed by Zeroc Inc. This framework features a lightweight but powerful and flexible inter-process communication infrastructure and provides binding to classic and modern programming languages, such as, C/C++, java, c#, ruby-rail, objective c, etc. The result of this work shows ICE as a real alternative for CORBA and other de-facto distribute programming framework. Classical control software architecture has been chosen and comprises an observation control system (OCS), the orchestrator of the observation, which controls the telescope control system (TCS), and detector control system (DCS). The real-time control and monitoring system is deployed and running over ARM based single board computers. Other features such as logging and configuration services have been developed as well. Inter-operation with other main astronomical control frameworks are foreseen in order achieve a smooth integration of instruments when they will be integrated in the main observatories in the north of Chile

Tackling the Transition to UC: To Implement Unified Communications on Campus, It Often Pays to Take a Phased Approach

ERIC Educational Resources Information Center

Ramaswami, Rama

2011-01-01

In this article, the author talks about the challenges faced by two schools that lie, coincidentally, just 110 miles apart in the vast spaces of North Dakota. Both schools, members of the North Dakota University System, decided to forge ahead with a unified communications (UC) implementation. And while their final solutions differ, how the two…

Characterization of UC781-Tenofovir Combination Gel Products for HIV-1 Infection Prevention in an Ex Vivo Ectocervical Model

PubMed Central

Cost, Marilyn; Dezzutti, Charlene S.; Clark, Meredith R.; Friend, David R.; Akil, Ayman

2012-01-01

HIV continues to be a problem worldwide. Topical vaginal microbicides represent one option being evaluated to stop the spread of HIV. With drug candidates that have a specific action against HIV now being studied, it is important that, when appropriate and based on the mechanism of action, the drug permeates the tissue so that it can be delivered to specific targets which reside there. Novel formulations of the nucleotide reverse transcriptase inhibitor tenofovir (TFV) and the nonnucleoside reverse transcriptase inhibitor UC781 have been developed and evaluated here. Gels with three distinct rheological properties were prepared. The three gels released both UC781 and TFV under in vitro conditions at concentrations equal to or above the reported 50% effective concentrations (EC50s). The drug concentrations in ectocervical tissues were well in excess of the reported EC50s. The gels maintain ectocervical viability and prevent infection of ectocervical explants after a HIV-1 challenge. This study successfully demonstrates the feasibility of using this novel combination of antiretroviral agents in an aqueous gel as an HIV infection preventative. PMID:22430977

On the Deduction of Galactic Abundances with Evolutionary Neural Networks

NASA Astrophysics Data System (ADS)

Taylor, M.; Diaz, A. I.

2007-12-01

A growing number of indicators are now being used with some confidence to measure the metallicity(Z) of photoionisation regions in planetary nebulae, galactic HII regions(GHIIRs), extra-galactic HII regions(EGHIIRs) and HII galaxies(HIIGs). However, a universal indicator valid also at high metallicities has yet to be found. Here, we report on a new artificial intelligence-based approach to determine metallicity indicators that shows promise for the provision of improved empirical fits. The method hinges on the application of an evolutionary neural network to observational emission line data. The network's DNA, encoded in its architecture, weights and neuron transfer functions, is evolved using a genetic algorithm. Furthermore, selection, operating on a set of 10 distinct neuron transfer functions, means that the empirical relation encoded in the network solution architecture is in functional rather than numerical form. Thus the network solutions provide an equation for the metallicity in terms of line ratios without a priori assumptions. Tapping into the mathematical power offered by this approach, we applied the network to detailed observations of both nebula and auroral emission lines from 0.33μ m-1μ m for a sample of 96 HII-type regions and we were able to obtain an empirical relation between Z and S_{23} with a dispersion of only 0.16 dex. We show how the method can be used to identify new diagnostics as well as the nonlinear relationship supposed to exist between the metallicity Z, ionisation parameter U and effective (or equivalent) temperature T*.

Characteristics of low energy ions in the Heavy Ions In Space (HIIS) experiment

NASA Technical Reports Server (NTRS)

Kleis, Thomas; Tylka, Allan J.; Boberg, Paul R.; Adams, James H., Jr.; Beahm, Lorraine P.

1995-01-01

We present preliminary data on heavy ions (Z greater than or equal to 10) detected in the topmost Lexan sheets of the track detector stacks of the Heavy Ions in space (HIIS) experiment (M0001) on LDEF. The energy interval covered by these observations varies with the element, with (for example) Ne observable at 18-100 MeV nuc and Fe at 45-200 MeV/nuc. All of the observed ions are at energies far below the geomagnetic cutoff for fully-ionized particles at the LDEF orbit. Above 50 MeV/nuc (where most of our observed particles are Fe), the ions arrive primarily from the direction of lowest geomagnetic cutoff. This suggests that these particles originate outside the magnetosphere from a source with a steeply-falling spectrum and may therefore be associated with solar energetic particle (SEP) events. Below 50 MeV/nuc, the distribution of arrival directions suggests that most of the observed heavy ions are trapped in the Earth's magnetic field. Preliminary analysis, however, shows that these trapped heavy ions have a very surprising composition: they include not only Ne and Ar, which are expected from the trapping of anomalous cosmic rays (ACR's), but also Mg and Si, which are not part of the anomalous component. Our preliminary analysis shows that trapped heavy ions at 12 less than or equal to Zeta less than or equal to 14 have a steeply-falling spectrum, similar to that reported by the Kiel experiment (exp 1,2,3) on LDEF (M0002) for trapped Ar and Fe at E less than 50 MeV/nuc. The trapped Mg, Si, and Fe may also be associated with SEP events, but the mechanism by which they have appeared to deep in the inner magnetosphere requires further theoretical investigation.

The role of unstable NH3 in the formation of nitrogen-rich alpha-U2N(3+x) by the reaction of UC or U with NH3

NASA Astrophysics Data System (ADS)

Katsura, Masahiro; Hirota, Masayuki; Miyake, Masanobu

1994-10-01

Reactions of U or UC with a stream of NH3 or N2 were carried out at 600 and 900 C. It has been found that in high temperature reactions of U or UC with flowing NH3, the catalytic decomposition of NH3 proceeds in parallel with the nitridation reaction of U or UC by action of NH3, which leads to the formation alpha-U2N(3+x), and eventually a steady state is established where the partial pressures of NH3, H2 and N2 (PNH3, PH2, and PN2) in the flowing gas and the N:U ratio of alpha-U2N(3+x) are all uniquely determined. The nitrogen activity a(sub N) of the flowing gas may be increased by suppressing the decomposition of NH3 into H2 and N2. The N:U ratio of alpha-U2N(3+x) increases as the extent of dissociation of NH3, alpha, decreases.

Infrared spectra and quantum chemical calculations of the uranium-carbon molecules UC, CUC, UCH, and U(CC)2

NASA Astrophysics Data System (ADS)

Wang, Xuefeng; Andrews, Lester; Ma, Dongxia; Gagliardi, Laura; Gonçalves, António P.; Pereira, Cláudia C. L.; Marçalo, Joaquim; Godart, Claude; Villeroy, Benjamin

2011-06-01

Laser evaporation of carbon rich uranium/carbon alloy targets into condensing argon or neon matrix samples gives weak infrared absorptions that increase on annealing, which can be assigned to new uranium carbon bearing species. New bands at 827.6 cm-1 in solid argon or 871.7 cm-1 in neon become doublets with mixed carbon 12 and 13 isotopes and exhibit the 1.0381 carbon isotopic frequency ratio for the UC diatomic molecule. Another new band at 891.4 cm-1 in argon gives a three-band mixed isotopic spectrum with the 1.0366 carbon isotopic frequency ratio, which is characteristic of the anti-symmetric stretching vibration of a linear CUC molecule. No evidence was found for the lower energy cyclic U(CC) isomer. Other bands at 798.6 and 544.0 cm-1 are identified as UCH, which has a uranium-carbon triple bond similar to that in UC. Evidence is found for bicyclic U(CC)2 and tricyclic U(CC)3. This work shows that U and C atoms react spontaneously to form the uranium carbide U≡C and C≡U≡C molecules with uranium-carbon triple bonds.

SOFIA/FORCAST Observations of the Arched Filamentary Region in the Galactic Center

NASA Astrophysics Data System (ADS)

Hankins, Matthew; Lau, Ryan M.; Morris, Mark; Herter, Terry L.

2016-06-01

Abstract: We present 19.7, 25.2, 31.5, and 37.1 μm maps of the Thermal Arched Filament region in the Galactic Center taken with the Faint Object Infrared Camera for the SOFIA Telescope (FORCAST) with an angular resolution of 3.2-3.8". We calculate the integrated infrared luminosity of the Arched Filaments and show that they are consistent with being heated by the nearby Arches cluster. Additionally, using our observations, we infer dust temperatures (75 - 90 K) across the Arched Filaments which are remarkably consistent over large spatial scales (˜ 25 pc). We discuss the possible geometric effects needed to recreate this temperature structure. Additionally, we compare the observed morphology of the Arches in the FORCAST maps with the Paschen-α emission in the region to study what fraction of the infrared emission may be coming from dust in the HII region versus the PDR beneath it. Finally, we use Spitzer/IRAC 8 μm data to look for spatial variations in PAH abundance in the rich UV environment of the young (~2-4 Myr) and massive Arches cluster.

Massive Stars and the Ionization of the Diffuse Medium

NASA Astrophysics Data System (ADS)

Kahre, Lauren E.; Walterbos, Rene A. M.

2015-08-01

Diffuse ionized Gas (DIG, sometimes called the warm ionized medium or WIM) has been recognized as a major component of the interstellar medium (ISM) in disk galaxies. A general understanding of the characteristics of the DIG is emerging, but several questions remain unanswered. One of these is the ionization mechanism for this gas, believed to be connected to OB stars and HII regions. Using 5-band (NUV (2750 A), U, V, B, and I) photometric imaging data from the Hubble Space Telescope (HST) Legacy Extragalactic Ultraviolet Survey (LEGUS) and ground-based Halpha data from the Local Volume Legacy (LVL) survey and HST Halpha data from LEGUS, we will investigate the photoionization of HII regions and DIG in nearly 50 galaxies. The 5-band photometry will enable us to determine properties of the most massive stars and reddening corrections for specific regions within a galaxy. Luminosities and ages for groups and clusters will be obtained from SED-fitting of photometric data. For individual stars ages will be determined from isochrone-fitting using reddening-corrected color-magnitude diagrams. We can then obtain estimates of the ionizing luminosities by matching these photometric properties for massive stars and clusters to various stellar atmosphere models. We will compare these predictions to the inferred Lyman continuum production rates from reddening-corrected ground- and HST-based Halpha data for HII regions and DIG. This particular presentation will demonstrate the above process for a set of selected regions in galaxies within the LEGUS sample. It will subsequently be expanded to cover the full LEGUS sample, with the overall goals of obtaining a better understanding of the radiative energy feedback from massive stars on the ISM, particularly their ability to ionize the surrounding ISM over a wide range of spatial scales and SFR surface densities, and to connect the ionization of the ISM to HII region morphologies.

Fractionation of radioactivity in the milk of goats administered UC-aflatoxin B1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goto, T.; Hsieh, D.P.

A detailed fractionation of radioactivity in the milk of goats administered UC-aflatoxin B1 at low doses was performed. The milk collected in the first 24 h following dosing contained radioactivity equivalent to 0.45-1.1% of the dose given. The radioactivity in each sample was partitioned into 4 fractions: ether, protein, dichloromethane, and water-alcohol. Over 80% of the radioactivity was detected in the dichloromethane fraction, of which over 95% was attributable to aflatoxin M1. No aflatoxin B1 or other known aflatoxin metabolites were detected in any fraction. The results indicate that the major metabolite of aflatoxin B1 in goat milk is aflatoxinmore » M1 and that other metabolites, including conjugates, are of minor significance.« less

Southern California Regional Technology Acceleration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ochoa, Rosibel; Rasochova, Lada

2014-09-30

UC San Diego and San Diego State University are partnering to address these deficiencies in the renewable energy space in the greater San Diego region, accelerating the movement of clean energy innovation from the university laboratory into the marketplace, building on the proven model of the William J. von Liebig Center’s (vLC’s) Proof of Concept (POC) program and virtualizing the effort to enable a more inclusive environment for energy innovation and expansion of the number of clean energy start-ups and/or technology licenses in greater California.

The Cosmic Abundance of 3He: Green Bank Telescope Observations

NASA Astrophysics Data System (ADS)

Balser, Dana; Bania, Thomas

2018-01-01

The Big Bang theory for the origin of the Universe predicts that during the first ~1,000 seconds significant amounts of the light elements (2H, 3He, 4He, and 7Li) were produced. Many generations of stellar evolution in the Galaxy modifies these primordial abundances. Observations of the 3He+ hyperfine transition in Galactic HII regions reveals a 3He/H abundance ratio that is constant with Galactocentric radius to within the uncertainties, and is consistent with the primordial value as determined from cosmic microwave background experiments (e.g., WMAP). This "3He Plateau" indicates that the net production and destruction of 3He in stars is approximately zero. Recent stellar evolution models that include thermohaline mixing, however, predict that 3He/H abundance ratios should slightly decrease with Galactocentric radius, or in places in the Galaxy with lower star formation rates. Here we discuss sensitive Green Bank Telescope (GBT) observations of 3He+ at 3.46 cm in a subset of our HII region sample. We develop HII region models and derive accurate 3He/H abundance ratios to better constrain these new stellar evolution models.

A study of the Galactic star forming region IRAS 02593+6016/S 201 in infrared and radio wavelengths

NASA Astrophysics Data System (ADS)

Ojha, D. K.; Ghosh, S. K.; Kulkarni, V. K.; Testi, L.; Verma, R. P.; Vig, S.

2004-03-01

We present infrared and radio continuum observations of the S 201 star forming region. A massive star cluster is seen, which contains different classes of young stellar objects. The near-infrared colour-colour and colour-magnitude diagrams are studied to determine the nature of these sources. We have discovered knots of molecular hydrogen emission at 2.122 μm in the central region of S 201. These knots are clearly seen along the diffuse emission to the north-west and are probably obscured Herbig-Haro objects. High sensitivity and high resolution radio continuum images from GMRT observations at 610 and 1280 MHz show an arc-shaped structure due to the interaction between the HII region and the adjacent molecular cloud. The ionization front at the interface between the HII region and the molecular cloud is clearly seen comparing the radio, molecular hydrogen and Brγ images. The emission from the carriers of Unidentified Infrared Bands in the mid-infrared 6-9 μm (possibly due to PAHs) as extracted from the Midcourse Space Experiment survey (at 8, 12, 14 and 21 μm) is compared with the radio emission. The HIRES processed IRAS maps at 12, 25, 60 and 100 μm have also been used for comparison. The spatial distribution of the temperature and the optical depth of the warm dust component around the S 201 region has been generated from the mid-infrared images. This paper is based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Centro Galileo Galilei of the CNAA (Consorzio Nazionale per l'Astronomia e l'Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. This publication makes use of data products from the Two Micron All Sky Survey, which is a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center/California Institute of Technology, funded by the National Aeronautics and Space Administration and the

Spitzer Space Telescope IRS Spectral Mapping of Photoionized Columns in M16 and the Carina HII Regions

NASA Astrophysics Data System (ADS)

Cotera, Angela; Simpson, J. P.; Sellgren, K.; Stolovy, S. R.

2013-01-01

Photoevaporated columns of dust and gas - also called elephant trunks, pillars or fingers - are found in the periphery of many H II regions. They have been observed within the Galaxy, the SMC and the LMC. These features are thought to be sites of current star formation, but the question remains whether the columns persist because stars formed in the denser regions prior to interactions with the UV radiation and stellar winds of nearby massive stars, or because of core collapse resulting from these interactions. We have obtained Spitzer IRS spectral maps of three columns within M 16 and three columns within the Carina nebula, to test our understanding of the impact on these transitory features of differing stellar populations and initial conditions. We use the wealth of molecular, atomic and PAH emission lines located within the spectral range of the high resolution IRS modes (9.9-37.2 micron) to determine the excitation state, dust and gas temperatures, and probe the shock characteristics within the columns as a function of location. Using the IRS spectral mapping mode, in conjunction with the CUBISM tool and the CLOUDY H II region model code, we have constructed detailed maps of the accessible emission lines and derived parameters for each column. Mapping the distribution of the physical states of the dust and gas in these columns is enhancing our understanding of the competing processes within these dynamic objects. The data presented here represent the only IRS spectral maps of photoionized pillars.

Shut out of the System: As Competition Increases for Slots at UC-Berkeley, Admission Offers to Minority Students Continue to Decline

ERIC Educational Resources Information Center

Burdman, Pamela

2004-01-01

As University of California officials announced admissions results for the fall, it appeared that increasing competition for seats at the university, rising tuition costs, and continued controversy over the role of race in admissions were conspiring to reduce the slots offered to African American students at UC-Berkeley. At the same time, the…

On the Nature and History of Blue Amorphous Galaxies

NASA Astrophysics Data System (ADS)

Marlowe, Amanda True

1998-07-01

Dwarf galaxies play an important role in our understanding of galaxy formation and evolution. We have embarked on a systematic study of 12 blue amorphous galaxies (BAGs) whose properties suggest that they are dwarf galaxies in a starburst or post-burst state. It seems likely that BAGs are related to other 'starburst' dwarfs such as blue compact dwarfs (BCDs) and HII galaxies. The BAGs in our sample, however, are considerably closer than BCDs and HII galaxies in other samples, and therefore easier to study. These galaxies may offer important insights into dwarf galaxy evolution. In an effort to clarify the role of BAGs in evolutionary scenarios for dwarf galaxies, we present and analyze Hα and UBVI data for our sample. BAGs, like BCDs and HII galaxies, have surface brightness profiles that are exponential in the outer regions but have a predominantly blue central blue excess, suggesting a young burst in an older, redder galaxy. Seven of the galaxies have the bubble or filamentary Hα morphology and double peaked emission lines that are the signature of superbubbles or superwind activity. These galaxies are typically the ones with the strongest central excesses. The starbursting regions are young events compared to the older underlying galaxy, which follow an exponential surface brightness law. Not all of the galaxies develop superwinds: the appearance of superwinds is most sensitive to the concentration and rate of star formation in the starbursting core. The underlying exponential galaxies are very similar to those found in BCDs and HII galaxies, though the 'burst' colors are slightly redder than those found in HII galaxies. BAGs are structurally similar to BCDs and HII galaxies. How BAGs fit into the dwarf galaxy evolutionary debate is less clear. While some compact dIs have properties similar to those of the underlying exponential galaxy in our sample, issues such as mass loss from superwinds, the impact of the starbursting core on the underlying galaxy, and

The effect of whole-body cooling on brain metabolism following perinatal hypoxic-ischemic injury.

PubMed

Corbo, Elizabeth T; Bartnik-Olson, Brenda L; Machado, Sandra; Merritt, T Allen; Peverini, Ricardo; Wycliffe, Nathaniel; Ashwal, Stephen

2012-01-01

Magnetic resonance imaging (MRI) and spectroscopy (MRS) have proven valuable in evaluating neonatal hypoxic-ischemic injury (HII). MRI scores in the basal ganglia of HII/HT(+) neonates were significantly lower than HII/HT(-) neonates, indicating less severe injury and were associated with lower discharge encephalopathy severity scores in the HII/HT(+) group (P = 0.01). Lactate (Lac) was detected in the occipital gray matter (OGM) and thalamus (TH) of significantly more HII/HT(-) neonates (31.6 and 35.3%) as compared to the HII/HT(+) group (10.5 and 15.8%). In contrast, the -N-acetylaspartate (NAA)-based ratios in the OGM and TH did not differ between the HII groups. Our data show that the HT was associated with a decrease in the number of HII neonates with detectable cortical and subcortical Lac as well as a decrease in the number of MRI-detectable subcortical lesions. We retrospectively compared the medical and neuroimaging data of 19 HII neonates who received 72 h of whole-body cooling (HII/HT(+)) with those of 19 noncooled HII neonates (HII/HT(-)) to determine whether hypothermia was associated with improved recovery from the injury as measured by MRI and MRS within the first 14 days of life. MRI scores and metabolite ratios of HII/HT(+) and HII/HT(-) neonates were also compared with nine healthy, nonasphyxiated "control" neonates.

Stellar population in star formation regions of galaxies

NASA Astrophysics Data System (ADS)

Gusev, Alexander S.; Shimanovskaya, Elena V.; Shatsky, Nikolai I.; Sakhibov, Firouz; Piskunov, Anatoly E.; Kharchenko, Nina V.

2018-05-01

We developed techniques for searching young unresolved star groupings (clusters, associations, and their complexes) and of estimating their physical parameters. Our study is based on spectroscopic, spectrophotometric, and UBVRI photometric observations of 19 spiral galaxies. In the studied galaxies, we found 1510 objects younger than 10 Myr and present their catalogue. Having combined photometric and spectroscopic data, we derived extinctions, chemical abundances, sizes, ages, and masses of these groupings. We discuss separately the specific cases, when the gas extinction does not agree with the interstellar one. We assume that this is due to spatial offset of Hii clouds with respect to the related stellar population.We developed a method to estimate age of stellar population of the studied complexes using their morphology and the relation with associated H emission region. In result we obtained the estimates of chemical abundances for 80, masses for 63, and ages for 57 young objects observed in seven galaxies.

Unveiling the Hot Molecular Core in the Ultracompact H II Region with Extended Emission G12.21-0.10

NASA Astrophysics Data System (ADS)

de la Fuente, E.; Trinidad, M. A.; Porras, A.; Rodríguez-Rico, C.; Araya, E. D.; Kurtz, S.; Hofner, P.; Nigoche-Netro, A.

2018-04-01

We present a multiwavelength study of the cometary H II region G12.21-0.10 using the VLA and OVRO. Both radio continuum (0.3, 0.7, 2 and 3.6 cm) and spectral lines of H41α, 13CS(2-1) & (1-0), and NH3(2,2) & (4,4) observations are included. We find two 3 mm continuum peaks toward G12.21-0.10; one of them is spatially coincident with the UC H II region, while the other coincides spatially with a molecular clump. We also find that the 0.7, 2 and 3.6 cm continuum and H41α line are only detected toward the UC H II region, while the 13CS, and NH3 are spatially associated with the molecular clump. Based on the morphology, kinetic temperature (≍86 K), volumetric density (≍1.5×106 cm-3) and linear size (≍0.22 pc) of the molecular clump, we suggest this source is consistent with a hot molecular core.

Re-dating Zhoukoudian Upper Cave, northern China and its regional significance.

PubMed

Li, Feng; Bae, Christopher J; Ramsey, Christopher B; Chen, Fuyou; Gao, Xing

2018-05-31

Due to the presence of multiple partial modern human skeletons thought to have been interred along with a diversity of evidence of symbolic behavior, Zhoukoudian Upper Cave (ZKD UC; formally "Choukoutien") from northern China has long been a critical site for understanding Late Quaternary human evolution and particularly the role eastern Asia played. Unfortunately, uncertainty regarding ZKD UC's chronology has long hindered determination of its importance in the debate over modern human origins. This situation has been particularly problematic because dates from the primary archaeological layers of ZKD UC have ranged from the Late Pleistocene to the Early Holocene (∼34-10 ka), with clearly different implications depending on which age is used. Here, we present a new set of accelerator mass spectrometry radiocarbon dating results from ZKD UC. Based on this new set of dates and further re-evaluations of the previous dating analyses, archaeological materials, published excavation reports and stratigraphy, we conclude that the ZKD UC archaeological layers minimally date to 35.1-33.5 ka. Given the similarities between the human fossils and archaeology between ZKD UC and western Eurasia, it is likely that the ZKD UC human foragers were part of dispersal events across northern Eurasia toward Siberia and eventually reaching into northern China. Copyright © 2018 Elsevier Ltd. All rights reserved.

Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.

PubMed

Gomez-Escalante, Susana; Piper, Peter W; Millson, Stefan H

2017-01-01

Folding of the myosin head often requires the joint actions of Hsp90 and a dedicated UNC45, Cro1, She4 (UCS) domain-containing cochaperone protein. Relatively weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS proteins of higher organisms (the general cell and smooth muscle UNC45s; UNC45-GC and UNC45-SM respectively). In vertebrates, UNC45-GC facilitates cytoskeletal function whereas the 55% identical UNC45-SM assists in the assembly of the contractile apparatus of cardiac and skeletal muscles. UNC45-SM, unlike UNC45-GC, shares with yeast She4 an IDSL sequence motif known to be a site of in vivo serine phosphorylation in yeast. Investigating this further, we found that both a non-phosphorylatable (S18A) and a phosphomimetic (S18E) mutant form of She4 could rescue the type 1 myosin localisation and endocytosis defects of the yeast she4Δ mutant at 39 °C. Nevertheless, at higher temperature (45 °C), only She4 (S18A), not She4(S18E), could substantially rescue the cell lysis defect of she4Δ mutant cells. In the yeast two-hybrid system, the non-phosphorylatable S18A and S251A mutant forms of She4 and UNC45-SM still displayed the stress-enhanced in vivo interaction with Hsp90 seen with the wild-type She4 and UNC45-SM. Such high-temperature enforcement to interaction was though lost with the phosphomimetic mutant forms (She4(S18E) and UNC45-SM (S251E)), an indication that phosphorylation might suppress these increases in She4/Hsp90 and UNC45-SM/Hsp90 interaction with stress.

Galactic Abundance Gradients fro IR Fine Strucuture LInes in Compact H II regions

NASA Technical Reports Server (NTRS)

Afflerbach, A.; Churchwell, E.; Werner, M. W.

1996-01-01

We present observations of the [S III]19(micro)m, [O III]52 and 88(micro)m, and [N III]57(micro)m lines toward 18 compact and ultracompact (UC) H II regions. These data were combined with data from the literature and high-resolution radio continuum maps to construct detailed statistical equilibrium and ionization equilibrium models of 34 compact H II regions located at galactocentric distances (Dg)0-12kpc. Our models simultaneously fit the observed IR fine-structure lines and high-resolution radio continuum maps.

Structural and optical characterization of NaGdF{sub 4}: Ho{sup 3+}/Yb{sup 3+} UC nano-particles for lateral finger mark detections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, A., E-mail: ak.phy87@gmail.com; Tiwari, S. P.; Krishna, K. M.

2016-05-23

Ho{sup 3+}/Yb{sup 3+} co-doped NaGdF{sub 4} up-conversion (UC) nano-particles were synthesized by thermal decomposition method. X-ray diffraction and FE-SEM image analysis were done to confirm the structure, morphology and determination of particle size. The UC emission spectra for as prepared as well as 100°C, 200°C, 300°C, 400°C, 800°C, 1000°C and 1200°C heated for 3h samples were recorded and there emission intensities were compared at a constant pump power of excitations 98.1 W/cm{sup 2}. The effect of emission intensity on decay time was also studied through focused and unfocused excitations. The synthesized material was successfully utilized in lateral finger mark detections onmore » the glass substrate through powder dusting method.« less

The observed spiral structure of the Milky Way

NASA Astrophysics Data System (ADS)

Hou, L. G.; Han, J. L.

2014-09-01

Context. The spiral structure of the Milky Way is not yet well determined. The keys to understanding this structure are to increase the number of reliable spiral tracers and to determine their distances as accurately as possible. HII regions, giant molecular clouds (GMCs), and 6.7 GHz methanol masers are closely related to high mass star formation, and hence they are excellent spiral tracers. The distances for many of them have been determined in the literature with trigonometric, photometric, and/or kinematic methods. Aims: We update the catalogs of Galactic HII regions, GMCs, and 6.7 GHz methanol masers, and then outline the spiral structure of the Milky Way. Methods: We collected data for more than 2500 known HII regions, 1300 GMCs, and 900 6.7 GHz methanol masers. If the photometric or trigonometric distance was not yet available, we determined the kinematic distance using a Galaxy rotation curve with the current IAU standard, R0 = 8.5 kpc and Θ0 = 220 km s-1, and the most recent updated values of R0 = 8.3 kpc and Θ0 = 239 km s-1, after velocities of tracers are modified with the adopted solar motions. With the weight factors based on the excitation parameters of HII regions or the masses of GMCs, we get the distributions of these spiral tracers. Results: The distribution of tracers shows at least four segments of arms in the first Galactic quadrant, and three segments in the fourth quadrant. The Perseus Arm and the Local Arm are also delineated by many bright HII regions. The arm segments traced by massive star forming regions and GMCs are able to match the HI arms in the outer Galaxy. We found that the models of three-arm and four-arm logarithmic spirals are able to connect most spiral tracers. A model of polynomial-logarithmic spirals is also proposed, which not only delineates the tracer distribution, but also matches the observed tangential directions. Appendix A is available in electronic form at http://www.aanda.orgFull Tables A.1-A.3 are only

Examination of UC-ZrC after long term irradiation at thermionic temperature

NASA Technical Reports Server (NTRS)

Yang, L.; Johnson, H. O.

1972-01-01

Two fluoride tungsten clad UC-ZrC fueled capsules, designated as V-2C and V-2D, were examined a hot cell after irradiation in NASA Plum Brook Reactor at a maximum cladding temperature of 1930 K for 11,089 and 12,031 hours to burnups of 3.0 x 10 to the 20th power and 2.1 x 10 to the 20th power fission/c.c. respectively. Percentage of fission gas release from the fuel material was measured by radiochemical means. Cladding deformation, fuel-cladding interaction and microstructures of fuel, cladding, and fuel-cladding interface were studied metallographically. Compositions of dispersions in fuel, fuel matrix and fuel-cladding interaction layer were analyzed by electron microprobe techniques. Axial and radial distributions of burnup were determined by gamma-scan, autoradiography and isotopic burnup analysis. The results are presented and discussed in conjunction with the requirements of thermionic fuel elements for space power application.

Binary system and jet precession and expansion in G35.20-0.74N

NASA Astrophysics Data System (ADS)

Beltrán, M. T.; Cesaroni, R.; Moscadelli, L.; Sánchez-Monge, Á.; Hirota, T.; Kumar, M. S. N.

2016-09-01

Context. Atacama Large Millimeter/submillimeter Array (ALMA) observations of the high-mass star-forming region G35.20-0.74N have revealed the presence of a Keplerian disk in core B rotating about a massive object of 18 M⊙, as computed from the velocity field. The luminosity of such a massive star would be comparable to (or higher than) the luminosity of the whole star-forming region. To solve this problem it has been proposed that core B could harbor a binary system. This could also explain the possible precession of the radio jet associated with this core, which has been suggested by its S-shaped morphology. Aims: We establish the origin of the free-free emission from core B and investigate the existence of a binary system at the center of this massive core and the possible precession of the radio jet. Methods: We carried out VLA continuum observations of G35.20-0.74N at 2 cm in the B configuration and at 1.3 cm and 7 mm in the A and B configurations. The bandwidth at 7 mm covers the CH3OH maser line at 44.069 GHz. Continuum images at 6 and 3.6 cm in the A configuration were obtained from the VLA archive. We also carried out VERA observations of the H2O maser line at 22.235 GHz. Results: The observations have revealed the presence of a binary system of UC/HC Hii regions at the geometrical center of the radio jet in G35.20-0.74N. This binary system, which is associated with a Keplerian rotating disk, consists of two B-type stars of 11 and 6 M⊙. The S-shaped morphology of the radio jet has been successfully explained as being due to precession produced by the binary system. The analysis of the precession of the radio jet has allowed us to better interpret the IR emission in the region, which would be not tracing a wide-angle cavity open by a single outflow with a position angle of ~55°, but two different flows: a precessing one in the NE-SW direction associated with the radio jet, and a second one in an almost E-W direction. Comparison of the radio jet images

Galactic Supernova Remnant Candidates Discovered by THOR

NASA Astrophysics Data System (ADS)

Anderson, Loren; Wang, Yuan; Bihr, Simon; Rugel, Michael; Beuther, Henrik; THOR Team

2018-01-01

There is a considerable deficiency in the number of known supernova remnants (SNRs) in the Galaxy compared to that expected. Searches for extended low-surface brightness radio sources may find new Galactic SNRs, but confusion with the much larger population of HII regions makes identifying such features challenging. SNRs can, however, be separated from HII regions using their significantly lower mid-infrared (MIR) to radio continuum intensity ratios. We use the combination of high-resolution 1-2 GHz continuum data from The HI, OH, Recombination line survey of the Milky Way (THOR) and lower-resolution VLA 1.4 GHz Galactic Plane Survey (VGPS) continuum data, together with MIR data from the Spitzer GLIMPSE, Spitzer MIPSGAL, and WISE surveys to identify SNR candidates. To ensure that the candidates are not being confused with HII regions, we exclude radio continuum sources from the WISE Catalog of Galactic HII Regions, which contains all known and candidate H II regions in the Galaxy. We locate 76 new Galactic SNR candidates in the THOR and VGPS combined survey area of 67.4deg>l>17.5deg, |b|<1.25deg and measure the radio flux density for 52 previously-known SNRs. The candidate SNRs have a similar spatial distribution to the known SNRs, although we note a large number of new candidates near l=30deg, the tangent point of the Scutum spiral arm. The candidates are on average smaller in angle compared to the known regions, 6.4'+/-4.7' versus 11.0'+/-7.8', and have lower integrated flux densities. If the 76 candidates are confirmed as true SNRs, for example using radio polarization measurements or by deriving radio spectral indices, this would more than double the number of known Galactic SNRs in the survey area. This large increase would still, however, leave a discrepancy between the known and expected SNR populations of about a factor of two.

Triggering Star Formation: From the Pillars of Creation to the Formation of Our Solar System

NASA Astrophysics Data System (ADS)

Gritschneder, Matthias; Lin, Douglas N. C.

We study the evolution of molecular clouds under the influence of ionizing radiation. We propose that the Pipe Nebula is an HII region shell swept up by the B2 IV β Cephei star θ Ophiuchi. After reviewing the recent observations, we perform a series of analytical calculations. We are able to show that the current size, mass and pressure of the region can be explained in this scenario. The Pipe Nebula can be best described by a three phase medium in pressure equilibrium. The pressure support is provided by the ionized gas and mediated by an atomic component to confine the cores at the observed current pressure. We then present simulations on the future evolution as soon as the massive star explodes in a supernova. We show that a surviving core at the border of the HII-region (D = 5 pc) is getting enriched sufficiently with supernova material and is triggered into collapse fast enough to be consistent with the tight constraints put by meteoritic data of e.g.26Al on the formation of our Solar System. We therefore propose that the formation of the Solar System was triggered by the shock wave of a type IIa supernova interacting with surviving cold structures similar to the Pillars of Creation at the border of HII-regions.

Ionized gas clouds near the Sagittarius Arm tangent

NASA Astrophysics Data System (ADS)

Hou, Li-Gang; Dong, Jian; Gao, Xu-Yang; Han, Jin-Lin

2017-04-01

Radio recombination lines (RRLs) are the best tracers of ionized gas. Simultaneous observations of multi-transitions of RRLs can significantly improve survey sensitivity. We conducted pilot RRL observations near the Sagittarius Arm tangent by using the 65-m Shanghai Tian Ma Radio Telescope (TMRT) equipped with broadband feeds and a digital backend. Six hydrogen RRLs (H96 α - H101α) at C band (6289 MHz-7319 MHz) were observed simultaneously toward a sky area of 2° × 1.2° by using on-the-fly mapping mode. These transitions were then stacked together for detection of ionized gas. Star forming complexes G48.6+0.1 and G49.5-0.3 were detected in the integrated intensity map. We found agreements between our measured centroid velocities and previous results for the 21 known HII regions in the mapped area. For more than 80 cataloged HII region candidates without previous RRL measurements, we obtained new RRL spectra at 30 targeted positions. In addition, we detected 25 new discrete RRL sources with spectral S/N > 5 σ, and they were not listed in the catalogs of previously known HII regions. The distances for 44 out of these 55 new RRL sources were estimated.

Poblacion estelar joven embebida en la nube molecular galactica asociada a la fuente IRAS 18236-1205

NASA Astrophysics Data System (ADS)

Romero, Ricardo Retes

2008-06-01

En esta tesis presento una metodología de seleccion y estudio de la población estelar embebida en la nube molecular galactica asociada a la fuente IRAS 18236-1205. La fuente IRAS posee colores de region Ultra Compacta HII (UCHII) y tiene deteccióon en monosulfuro de carbono (CS), trazador molecular de alta densidad, lo cual da la posibilidad de definir la nube molecular asociada hacia esta region. Lo anterior muestra que esta es buena candidata a región de formación estelar masiva. La metodología de seleccion de la población embebida, est à basada por una parte, en la distribución del gas molecular monoxido de carbono (13CO) asociado a la fuente IRAS, nube molecular seleccionada del mapeo Galactic Ring Survey (GRS) realizado en 13CO. Otros pasos de la seleccion, se basan en los diagramas color-color y color-magnitud con datos del cercano infrarrrojo de 2MASS. Para el estudio de la componente estelar se usaron los catalogos de fuentes puntuales en el cercano, medio y lejano infrarrojo de 2MASS, SPITZER e IRAS, respectivamente. De los diagramas color-color y color-magnitud, usando datos de 2MASS, se construyo un criterio fotométrico para identificar los objetos estelares j ovenes embebidos en la region molecular. Aplicando modelos a la distribución espectral de energía (SED) de algunos ellos, se encontraron parametros estelares de objetos estelares j ovenes embebidos de masa intermedia y alta. Adicionalmente, se encontro un objeto de masa ´ intermedia no identifiado por el catalogo de 2MASS y su efecto sobre el medio interestelar, emision en la banda de [4.5] μm de IRAC-Spitzer asociado a un outflow. Dos de los objetos seleccionados por el criterio fotometrico resultaron ser objetos estelares jovenes de alta e intermedia masa (B1V/B2V y B8V/A0V respectivamente), los cuales deben estar asociados a la emision radiativa responsable de los colores de región UC HII. Otro objeto estelar joven de baja masa (F0V/F5V) fue encontrado en la region de estudio

High-mass Star Formation and Its Initial Conditions

NASA Astrophysics Data System (ADS)

Zhang, C. P.

2017-11-01

In this thesis, we present four works on the infrared dark clouds, fragmentation and deuteration of compact and cold cores, hyper-compact (HC) HII regions, and infrared dust bubbles, respectively. They are not only the products of early high-mass star formation, but reflect different evolutionary sequences of high-mass star formation. (1) Using the IRAM (Institut de Radioastronomie Millimétrique) 30 m telescope, we obtained HCO^+, HNC, N_2^+, and C^{18}O emission in six IRDCs (infrared dark clouds), and study their dynamics, stability, temperature, and density. (2) Fragmentation at the earliest phases is an important process of massive star formation. Eight massive precluster clumps (G18.17, G18.21, G23.97N, G23.98, G23.44, G23.97S, G25.38, and G25.71) were selected from the SCUBA (submillimetre Common-User Bolometer Array) 850 μm and 450 μm data. The VLA (Very Large Array) at 1.3 cm, PbBI at 3.5 mm and 1.3 mm, APEX (Atacama Pathfinder Experiment telescope) at 870 μm observations were followed up, and archival infrared data at 4.5 μm, 8.0 μm, 24 μm, and 70 μm were combined to study the fragmentation and evolution of these clumps. We explored the habitats of the massive clumps at large scale, cores/condensations at small scale, and the fragmentation process at different wavelengths. Star formation in these eight clumps may have been triggered by the UC (ultra-compact) HII regions nearby. (3) The formation of hyper-compact (HC) HII regions is an important stage in massive star formation. We present high angular resolution observations carried out with the SMA (Submillimeter Array) and the VLA (Very Large Array) toward the HC HII region G35.58-0.03. With the 1.3 mm SMA and 1.3 cm VLA, we detected a total of about 25 transitions of 8 different species and their isotopologues (CO, CH_3CN, SO_2, CH_3CCH, OCS, CS, H30α/38β, and NH_{3}). G35.58-0.03 consists of an HC HII core with electron temperature Te* ≥ 5500 K, emission measure EM ≈ 1.9×10^{9} pc

A census of Hα emitters in the intergalactic medium of the NGC 2865 system

NASA Astrophysics Data System (ADS)

Urrutia-Viscarra, F.; Arnaboldi, M.; Mendes de Oliveira, C.; Gerhard, O.; Torres-Flores, S.; Carrasco, E. R.; de Mello, D.

2014-09-01

Tidal debris, which are rich in HI gas and formed in interacting and merging systems, are suitable laboratories to study star formation outside galaxies. Recently, several such systems were observed, which contained many young star forming regions outside the galaxies. In previous works, we have studied young star forming regions outside galaxies in different systems with optical and/or gaseous tidal debris, in order to understand how often they occur and in which type of environments. In this paper, we searched for star forming regions around the galaxy NGC 2865, a shell galaxy that is circled by a ring of HI with a total mass of 1.2 × 109 M⊙. Using the multi-slit imaging spectroscopy technique with the Gemini telescope, we detected all Hα emitting sources in the surroundings of the galaxy NGC 2865, down to a flux limit of 10-18 erg cm-2 s-1 Å-1. With the spectra information and the near and far-ultraviolet flux, we characterize the star formation rates, masses, ages, and metallicities for these HII regions. In total, we found 26 emission-line sources in a 60 × 60 Kpc field centered over the southeastern tail of the HI gas present around the galaxy NGC 2865. Out of the 26 Hα emitters, 19 are in the satellite galaxy FGCE 0745, and seven are intergalactic HII regions scattered over the south tail of the HI gas around NGC 2865. We found that the intergalactic HII regions are young (<200 Myr) with stellar masses in the range 4 × 103 M⊙ to 17 × 106 M⊙. These are found in a region of low HI gas density, where the probability of forming stars is expected to be low. For one of the intergalactic HII regions, we estimated a solar oxygen abundance of 12 + log(O/H) ~ 8.7. We also were able to estimate the metallicity for the satellite galaxy FGCE 0745 to be 12 + log(O/H) ~ 8.0. Given these physical parameters, the intergalactic HII regions are consistent with young star forming regions (or clusters), which are born in situ outside the NGC 2865 galaxy from a pre

Graduate and Professional School Applications, Admissions and Enrollments (1981-1988): A Status Report on Ethnic Groups Underrepresented at UC Davis. Research Synopsis No. 29.

ERIC Educational Resources Information Center

California Univ., Davis. Office of Student Affairs Research and Information.

This report describes postgraduate enrollment trends for ethnic groups underrepresented at University of California, Davis. The UC Davis Student Affirmative Action (SAA) Plan identifies the following groups as underrepresented in both the Graduate Division and professional schools: American Indian, Black/African-American, Chicano/Mexican American,…

[Integrated management of patients with chronic inflammatory bowel disease in the Rhine-Main Region: results of the first integrated health-care project IBD in Germany].

PubMed

Blumenstein, I; Tacke, W; Filmann, N; Zosel, C; Bock, H; Heuzeroth, V; Zeuzem, S; Schröder, O

2013-07-01

In our previous studies investigating the drug therapy in patients suffering from inflammatory bowel disease (IBD) in the Rhein-Main region, Germany, we detected serious discrepancies between treatment reality and treatment guidelines. Consecutively, patient outcome in this cohort was compromised. Following this pilot project a network between primary deliverers of care for IBD patients and one large health-care insurance company [BKK Taunus (Gesundheit), the second largest insurance company in Hessen, Germany] was established. An analysis of treatment and socioeconomic data from 220 IBD patients (Crohn's disease - CD = 96, ulcerative colitis - UC = 124) entering the integrative health-care programme between 1.1.-30.9.2009 was performed. Remission rates for CD and UC in the integrated health-care programme could be improved from 60 - 73 % (CD) and from 61 - 79 % (UC). Guideline-conform treatment was observed in 81 % of patients with CD and 85 % with UC, respectively. Although medication costs increased, total costs could be cut by 162 304.- €, as secondary costs for hospitalisation and days off work could be reduced. The study shows that networking of deliverers of care for IBD patients with health insurances provides an excellent possibility to optimise medical treatment and can cut down costs significantly. © Georg Thieme Verlag KG Stuttgart · New York.

Physical and genetic map of Streptococcus thermophilus A054.

PubMed Central

Roussel, Y; Pebay, M; Guedon, G; Simonet, J M; Decaris, B

1994-01-01

The three restriction endonucleases SfiI, BssHII, and SmaI were found to generate fragments with suitable size distributions for mapping the genome of Streptococcus thermophilus A054. A total of 5, 8, and 24 fragments were produced with SfiI, BssHII, and SmaI, respectively. An average genome size of 1,824 kb was determined by summing the total fragment sizes obtained by digestions with these three enzymes. Partial and multiple digestions of genomic DNA in conjunction with Southern hybridization were used to map SfiI, BssHII, and SmaI fragments. All restriction fragments were arranged in a unique circular chromosome. Southern hybridization analysis with specific probes allowed 23 genetic markers to be located on the restriction map. Among them, six rrn loci were precisely located. The area of the chromosome containing the ribosomal operons was further detailed by mapping some of the ApaI and SgrAI sites. Comparison of macrorestriction patterns from three clones derived from strain A054 revealed two variable regions in the chromosome. One was associated with the tandem rrnD and rrnE loci, and the other was mapped in the region of the lactose operon. Images PMID:8002562

pYEMF, a pUC18-derived XcmI T-vector for efficient cloning of PCR products.

PubMed

Gu, Jingsong; Ye, Chunjiang

2011-03-01

A 1330-bp DNA sequence with two XcmI cassettes was inserted into pUC18 to construct an efficient XcmI T-vector parent plasmid, pYEMF. The large size of the inserted DNA fragment improved T-vector cleavage efficiency, and guaranteed good separation of the molecular components after restriction digestion. The pYEMF-T-vector generated from parent plasmid pYEMF permits blue/white colony screening; cloning efficiency analysis showed that most white colonies (>75%) were putative transformants which carried the cloning product. The sequence analysis and design approach presented here will facilitate applications in the fields of molecular biology and genetic engineering.

An open, component-based information infrastructure for integrated health information networks.

PubMed

Tsiknakis, Manolis; Katehakis, Dimitrios G; Orphanoudakis, Stelios C

2002-12-18

A fundamental requirement for achieving continuity of care is the seamless sharing of multimedia clinical information. Different technological approaches can be adopted for enabling the communication and sharing of health record segments. In the context of the emerging global information society, the creation of and access to the integrated electronic health record (I-EHR) of a citizen has been assigned high priority in many countries. This requirement is complementary to an overall requirement for the creation of a health information infrastructure (HII) to support the provision of a variety of health telematics and e-health services. In developing a regional or national HII, the components or building blocks that make up the overall information system ought to be defined and an appropriate component architecture specified. This paper discusses current international priorities and trends in developing the HII. It presents technological challenges and alternative approaches towards the creation of an I-EHR, being the aggregation of health data created during all interactions of an individual with the healthcare system. It also presents results from an ongoing Research and Development (R&D) effort towards the implementation of the HII in HYGEIAnet, the regional health information network of Crete, Greece, using a component-based software engineering approach. Critical design decisions and related trade-offs, involved in the process of component specification and development, are also discussed and the current state of development of an I-EHR service is presented. Finally, Human Computer Interaction (HCI) and security issues, which are important for the deployment and use of any I-EHR service, are considered.

Multi-Wavelength Diagnostics of Starbirth in Starbursts

NASA Astrophysics Data System (ADS)

Waller, William

2005-07-01

From the Orion Nebula to the Hubble Deep Field, starburst activity can be seen transforming galaxian clouds of gas into populous clusters of stars. The pyrotechnics and chemical enrichment associated with this activity have led to outcomes as ubiquitous as interstellar dust and as exquisite as life on Earth. In this talk, I will focus on the circumstances of star formation in the environmental context of ongoing starburst activity. I begin with the premises that (1) the formation of a single star takes time, (2) the formation of a populous cluster takes even more time, and (3) ``stuff'' happens in the interim. Hubble images of the Orion Nebula and Eagle Nebula show how hot stars can excavate neighboring clouds of gas and photoevaporate the star-forming cores that are exposed. Hubble observations of giant HII regions in M33 reveal a significant variation in the stellar populations, such that the most metal-rich HII regions contain the greatest proportions of the most massive stars. ISO and Spitzer observations of these same HII regions reveal corresponding variations in the nebular response. These multi-wavelength diagnostics of the stellar-nebular feedback in galaxian starbursts suggest a star-forming mechanism which is subject to photo-evaporative ablation -- an erosive process that is mediated by the metal abundance and corresponding amounts of protective dust in the starbursting environment.

Study of chromosomal region 5p13.1 in Crohn's disease, ulcerative colitis, and rheumatoid arthritis.

PubMed

Perdigones, Nieves; Martín, Ezequiel; Robledo, Gema; Lamas, José Ramón; Taxonera, Carlos; Díaz-Rubio, Manuel; de la Concha, Emilio G; López-Nevot, Miguel Angel; García, Antonio; Gómez-García, María; Fernández-Gutiérrez, Benjamín; Martín, Javier; Urcelay, Elena

2010-08-01

Chromosomal region 5p13 includes regulatory elements of the prostaglandin receptor EP4 (PTGER4) gene and is associated with inflammatory bowel disease (IBD) susceptibility. We aimed at corroborating the association of the PTGER4 risk variant in IBD. Given the proinflammatory activity of prostaglandin E(2) in rheumatoid arthritis (RA), the reduction in incidence and severity of collagen-induced arthritis observed in mice deficient in the prostaglandin receptor EP4, and a modest signal of association found in an RA genome-wide scan, we proposed to extend the investigation of this locus to RA patients. A total of 709 Crohn's disease (CD) patients, 662 ulcerative colitis (UC) patients, and 1369 control subjects were genotyped for rs17234657. This polymorphism was also analyzed in 605 RA patients, and rs6871834 was studied in the RA patient group. Replication of the previous finding in CD was achieved in our independent collections, although with a milder effect (odds ratios = 1.23) than that originally described. No further association of the previously mentioned polymorphisms was detected with either UC or RA patients. We validated this 5p13 signal as a genuine susceptibility factor for CD in Caucasian populations. Our data seem to rule out a major influence of these polymorphisms on UC or RA predisposition. Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Nucleosynthesis of intermediate mass stars: inferences from the observed abundances in photoionized nebulae of the Local Group

NASA Astrophysics Data System (ADS)

Maciel, W. J.; Costa, R. D. D.; Cavichia, O.

2018-01-01

Photoionized nebulae, comprising HII regions and planetary nebulae, are excellent laboratories to investigate the nucleosynthesis and chemical evolution of several elements in the Galaxy and other galaxies of the Local Group. Our purpose in this investigation is threefold: (i) to compare the abundances of HII regions and planetary nebulae in each system in order to investigate the differences derived from the age and origin of these objects, (ii) to compare the chemical evolution in different systems, such as the Milky Way, the Magellanic Clouds, and other galaxies of the Local Group, and (iii) to investigate to what extent the nucleosynthesis contributions from the progenitor stars affect the observed abundances in planetary nebulae, especially for oxygen and neon, which places constraints on the amount of these elements that can be produced by intermediate mass stars.

Inflammatory bowel disease incidence in Czech children: A regional prospective study, 2000-2015

PubMed Central

Schwarz, Jan; Sýkora, Josef; Cvalínová, Dominika; Pomahačová, Renáta; Klečková, Jana; Kryl, Martin; Včelák, Petr

2017-01-01

AIM To examine the incidence and trends in pediatric inflammatory bowel diseases (IBDs) over 2000-2015 and project the incidence to 2018. METHODS A 16-year prospective study of IBD patients < 19 years of age was conducted in the Czech Republic (the Pilsen region). All incident IBD cases within a well-defined geographical area were retrieved from a prospectively collected computerized clinical database. Historical Czech data were used for comparison (1990-2001). Our catchment population was determined from the census data. We calculated the incidence by relating the number of newly diagnosed cases to the size of the pediatric population-at-risk in each calendar year. Age/sex, disease type, place of residence, and race/ethnicity were identified. RESULTS In total, 170 new IBD cases [105 Crohn’s disease (CD), 48 ulcerative colitis (UC), and 17 IBD-unclassified (IBD-U)] were identified. The median age at IBD diagnosis was 14.2 years, 59.4% were males, and 97.1% were Caucasians. A male preponderance of IBD (P = 0.026) and CD (P = 0.016) was observed. With 109209 person-years in the catchment area, the average incidence of IBD per 100000 person-years was 10.0 (6.2 for CD, 2.8 for UC, and 1.0 for IBD-U) for children aged 0 to 19 years; for those aged 0 to 15 years, the incidence rate was 7.3 (4.6 for CD, 2.0 for UC, and 0.7 for IBD-U). An increase in incidence with age was observed (P = 0.0003). Over the 16-year period, the incidence increased for IBD patients (P = 0.01) and CD in particular (P < 0.0001), whereas the incidence for UC (P = 0.09) and IBD-U (P = 0.339) remained unchanged. IBD-projected data from 2016 to 2018 were 12.1, 12.3 and 12.6 per 100000 person-years, respectively. CONCLUSION Pediatric-onset IBD incidence is around its highest point. The increase, which is particularly pronounced for CD, may be challenging to relate to causes of pediatric disease. PMID:28652662

Post-Vietnam military herbicide exposures in UC-123 Agent Orange spray aircraft.

PubMed

Lurker, Peter A; Berman, Fred; Clapp, Richard W; Stellman, Jeanne Mager

2014-04-01

During the Vietnam War, approximately 20 million gallons of herbicides, including ~10.5 million gallons of dioxin-contaminated Agent Orange, were sprayed by about 34 UC-123 aircraft that were subsequently returned to the United States, without decontamination or testing, to three Air Force reserve units for transport operations (~1971-1982). In 1996, observed dioxin contamination led to withdrawal of these UC-123s from public auction and to their smelting in 2009. Current Air Force and Department of Veterans Affairs policies stipulate that "dried residues" of chemical herbicides and dioxin had not lead to meaningful exposures to flight crew and maintenance personnel, who are thus ineligible for Agent Orange-related benefits or medical examinations and treatment. Sparse monitoring data are available for analysis. Three complementary approaches for modeling potential exposures to dioxin in the post-Vietnam war aircraft were employed: (1) using 1994 and 2009 Air Force surface wipe data to model personnel exposures and to estimate dioxin body burden for dermal-oral exposure for dried residues using modified generic US Environmental Protection Agency intake algorithms; (2) comparing 1979 Air Force 2,4- dichlorophenoxyacetic acid and 2,4-5-trichlorophenoxyacetic acid air samples to saturated vapor pressure concentrations to estimate potential dioxin exposure through inhalation, ingestion and skin contact with contaminated air and dust; and (3) applying emission models for semivolatile organic compounds from contaminated surfaces to estimate airborne contamination. Model (1): Body-burden estimates for dermal-oral exposure were 0.92 and 5.4pg/kg body-weight-day for flight crew and maintainers. The surface wipe concentrations were nearly two orders of magnitude greater than the US Army guidance level. Model (2): measured airborne concentrations were at least five times greater than saturated vapor pressure, yielding dioxin estimates that ranged from 13.2-27.0pg/m(3), thus

Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.

PubMed

Glas, Jürgen; Stallhofer, Johannes; Ripke, Stephan; Wetzke, Martin; Pfennig, Simone; Klein, Wolfram; Epplen, Jörg T; Griga, Thomas; Schiemann, Uwe; Lacher, Martin; Koletzko, Sibylle; Folwaczny, Matthias; Lohse, Peter; Göke, Burkhard; Ochsenkühn, Thomas; Müller-Myhsok, Bertram; Brand, Stephan

2009-07-01

Recently, a genome-wide association study showed that single-nucleotide polymorphisms (SNPs) in the chromosome 4q27 region containing IL2 and IL21 are associated with celiac disease. Given the increased prevalence of inflammatory bowel disease (IBD) among celiac disease patients, we investigated the possible involvement of these SNPs in IBD. Five SNPs strongly associated with celiac disease within the KIAA1109/TENR/IL2/IL21 linkage disequilibrium block on chromosome 4q27 and one coding SNP within the IL21 gene were analyzed in a large German IBD cohort. The study population comprised a total of 2,948 Caucasian individuals, including 1,461 IBD patients (ulcerative colitis (UC): n=514, Crohn's disease (CD): n=947) and 1,487 healthy unrelated controls. Three of the five celiac disease risk markers had a protective effect on UC susceptibility, and this effect remained significant after correcting for multiple testing: rs6840978: P=0.0082, P(corr)=0.049, odds ratio (OR) 0.77, 95% confidence interval (CI) 0.63-0.93; rs6822844: P=0.0028, P(corr)=0.017, OR 0.73, 95% CI 0.59-0.90; rs13119723: P=0.0058, P(corr)=0.035, OR 0.75, 95% CI 0.61-0.92. A haplotype consisting of the six SNPs tested was markedly associated with UC susceptibility (P=0.0025, P(corr)=0.015, OR 0.72, 95% CI 0.58-0.89). Moreover, in UC, epistasis was observed between the IL23R SNP rs1004819 and three SNPs in the KIAA1109/TENR/IL2/IL21 block (rs13151961, rs13119723, and rs6822844). Similar to other autoimmune diseases such as celiac disease, rheumatoid arthritis, type 1 diabetes, Graves' disease, and psoriatic arthritis, genetic variation in the chromosome 4q27 region predisposes to UC, suggesting a common genetic background for these diseases.

Inflammatory bowel disease in the Asia-Pacific area: a comparison with developed countries and regional differences.

PubMed

Ahuja, Vineet; Tandon, Rakesh K

2010-06-01

The Asia-Pacific region has been marked as an area with a low incidence of inflammatory bowel disease (IBD), although confusion always existed as to whether this low incidence was a result of low diagnostic awareness, a high incidence of infective diarrhoea and its diagnostic overlap or a true low incidence. As epidemiological studies from this region are being made available it is clear that the incidence and prevalence rates of IBD in Asia-Pacific region are low compared with Europe and North America. They are however, increasing rapidly. There are substantial variations in the incidence and prevalence rates of IBD in various ethnic groups in Asia. The highest incidence rates are recorded from India, Japan and the Middle East and there exists a genetic predisposition of South Asians (Indians, Pakistanis and Bangladeshis) to ulcerative colitis (UC). It appears that certain racial groups are more prone than others to develop IBD. For instance, Indians in South-East Asia have higher rates than Chinese and Malays. While there is a host genetic predisposition, environmental factor(s) may be responsible for this difference. The clinical phenotypes and complication rates of Asian IBD resemble those of the Caucasian population in general, but some heterogeneity is observed in different regions of Asia. There is no evidence of a north-south or an east-west divide in the Asia-Pacific region. The available studies suggest an increasing incidence of UC in the Asia-Pacific region and hence it is an appropriate time to launch well-designed epidemiological studies so that etiopathogenetic factors can be identified. There is a male predominance in Crohn's disease in the Asian population. The NOD2/CARD15 gene is not associated with CD in the Japanese, Korean, Chinese and Indian population.

VizieR Online Data Catalog: CALIFA color/metallicity gradients connections (Marino+, 2016)

NASA Astrophysics Data System (ADS)

Marino, R. A.; Gil de Paz, A.; Sanchez, S. F.; Sanchez-Blazquez, P.; Cardiel, N.; Castillo-Morales, A.; Pascual, S.; Vilchez, J.; Kehrig, C.; Molla, M.; Mendez-Abreu, J.; Catalan-Torrecilla, C.; Florido, E.; Perez, I.; Ruiz-Lara, T.; Ellis, S.; Lopez-Sanchez, A. R.; Gonzalez Delgado, R. M.; de Lorenzo-Caceres, A.; Garcia-Benito, R.; Galbany, L.; Zibetti, S.; Cortijo, C.; Kalinova, V.; Mast, D.; Iglesias-Paramo, J.; Papaderos, P.; Walcher, C. J.; Bland-Hawthorn, J.

2016-03-01

We have selected the 350 galaxies observed by the CALIFA survey (Sanchez et al., 2012A&A...538A...8S) at the CAHA 3.5m telescope with Potsdam Multi Aperture Spectrograph (PMAS) in the PPak mode and processed by the CALIFA v1.5 pipeline up to September 2014. The SDSS g' and r' SB and (g'-r') color profiles were derived using the DR10 data products, in particular, we used the swarp mosaicking code (Ahn et al., 2014ApJS..211...17A). We obtain spectroscopic information for ~15130 HII regions (or complexes) from our 324 CALIFA data cubes using HII explorer. (2 data files).

X-ray ionization of the intergalactic medium by quasars

NASA Astrophysics Data System (ADS)

Graziani, Luca; Ciardi, B.; Glatzle, M.

2018-06-01

We investigate the impact of quasars on the ionization of the surrounding intergalactic medium (IGM) with the radiative transfer code CRASH4, now accounting for X-rays and secondary electrons. After comparing with analytic solutions, we post-process a cosmic volume (≈1.5 × 104 Mpc3h-3) containing a ULAS J1120+0641-like quasar (QSO) hosted by a 5 × 1011M⊙h-1 dark matter (DM) halo. We find that: (i) the average HII region (R ˜ 3.2 pMpc in a lifetime tf = 107 yrs) is mainly set by UV flux, in agreement with semi-analytic scaling relations; (ii) a largely neutral (xHII < 0.001), warm (T ˜ 103 K) tail extends up to few Mpc beyond the ionization front, as a result of the X-ray flux; (iii) LyC-opaque inhomogeneities induce a line of sight (LOS) scatter in R as high as few physical Mpc, consistent with the DLA scenario proposed to explain the anomalous size of the ULAS J1120+0641 ionized region. On the other hand, with an ionization rate \\dot{N}_{γ ,0} ˜ 10^{57} s-1, the assumed DLA clustering and gas opacity, only one LOS shows an HII region compatible with the observed one. We deduce that either the ionization rate of the QSO is at least one order of magnitude lower or the ULAS J1120+0641 bright phase is shorter than 107 yrs.

Physical properties of the ionized gas and brightness distribution in NGC4736

NASA Astrophysics Data System (ADS)

Rodrigues, I.; Dottori, H.; Cepa, J.; Vilchez, J.

1998-03-01

In this work we study the galaxy NGC4736, using narrow band interference filters imaging centered at the emission lines {Oii} {3727+3729}, Hβ, {Oiii} {5007}, Hα, {Sii} {6716+6730} and {Siii} {9070} and nearby continua. We have obtained sizes, positions, emission line absolute fluxes, and continua intensities for 90 Hii regions, mainly distributed in a ring-like structure of 3.2kpc in diameter. The Hα luminosities are in the range 37.3 <= log L_Hα <= 39.4 ergs(-1) . The Hii regions size distribution presents a characteristic diameter D_0 = 115pc and verifies the relation log (L_Hα ) ~D(3) . The temperature of the ionizing sources and the metallicity of the Hii regions are respectively in the ranges 3.410(4) <~T_⋆ <~ 4.010(4) K and 8.5 <~12 + log (O/H) <~9.3. The masses of the ionizing clusters are in the range 510(3) <~M_T/M_sun <~210(5) . The continua radial surface brightness distribution is better fitted by the superposition of a de Vaucouleurs', a thin and a thick exponential disk laws. The monochromatic colors show that outside the star forming ring the disk presents a younger stellar population than inside it. Tables 3 and 4 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html

Costs of ulcerative colitis from a societal perspective in a regional health care area in Spain: A database study.

PubMed

Aldeguer, Xavier; Sicras-Mainar, Antoni

2016-01-01

To estimate the management of UC associated costs from the societal perspective in Spain. Observational, longitudinal study with retrospective data collection based on reviews of outpatient health records. Socio-demographic, clinical and sick leave information was gathered. Patients diagnosed of UC between 2002 and 2012, older than 18 years, followed-up by a minimum of 12 months post diagnosis, with at least two clinical and use of resources data recorded, were included. 285 UC patients [51.2% men; 44.5 (SD: 15.6) years old; 88.4% without family history of UC; 39.3% proctitis; 5.6 (2.5) years disease follow-up] participated. More than half (65.6%) were active workers, 75.9% were on sick leave for reasons different from UC [mean 0.66 (0.70) times per year] during (mean) 28.43 (34.45) days. Only 64 patients were on UC-related sick-leaves, lasting (mean) 26.17 (37.43) days. Absenteeism due to medical visits caused loss of 29.55 (21.38) working hours per year. Mean direct and indirect annual cost per UC patient were €1754.10 (95%CI: 1473.37-2034.83) and €399.32 (282.31-422.69), respectively. Absenteeism was estimated at €88.21(32.72-50.06) per patient per year, in which sick-leaves were the main component of indirect costs (88.2%). Age, UC family history, diarrhea at diagnosis, blood and blood-forming organs diseases and psychological disorders were the main predictors of indirect costs. UC is a costly disease for the society and the Spanish National Healthcare System. Indirect costs imply a major burden by affecting the most productive years of patients. Further research is needed considering all components of productivity loss, including presenteeism-associated costs. Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

Change of motion and localization of cholesterol molecule during L(alpha)-H(II) transition.

PubMed Central

Hayakawa, E; Naganuma, M; Mukasa, K; Shimozawa, T; Araiso, T

1998-01-01

Formation of the inverted hexagonal (H(II)) phase from the lamellar (L(alpha)) phase of bovine brain-extracted phosphatidylcholine (BBPC) and phosphatidylethanolamine (BBPE) was investigated using 31P-NMR with or without cholesterol. When the ratio of BBPC to BBPE was 1:1, the H(II) formation was observed in the presence of 33 mol% cholesterol (i.e., BBPC:BBPE:cholesterol = 1:1:1) at 47 degrees C. The fraction of the H(II) phase in the BBPC/BBPE/cholesterol system could be controlled by the addition of dioleoylglycerol. The change of molecular motion of cholesterol affected by the H(II) formation was measured at various ratios of the L(alpha) to H(II) phase with the time-resolved fluorescence depolarization method, using dehydroergosterol as a fluorescent probe. It is observed that the motion of cholesterol became vigorous in the mixture state of the L(alpha) and the H(II) phases compared to that in the L(alpha) or the H(II) phase only. These facts show that cholesterol has the strong ability to induce the H(II) phase, probably by special molecular motion, which includes change of its location from the headgroup area to the acyl-chain area. PMID:9533700

VizieR Online Data Catalog: Bubble HII region Sh2-39 (N5) (Duronea+, 2017)

NASA Astrophysics Data System (ADS)

Duronea, N. U.; Cappa, C. E.; Bronfman, L.; Borissova, J.; Gromadzki, M.; Kuhn, M. A.

2017-06-01

The molecular observations were carried out in August 2015 with the 10m Atacama Submillimeter Telescope Experiment (ASTE). We used DASH345, a two sideband single-polarization heterodyne receiver, tunable in LO frequency range from 327GHz to 370GHz at observable frequency range from 321GHz to 376GHz. The XF digital spectrometer was set to a bandwidth and spectral resolution of 128MHz and 125KHz, respectively. The spectral velocity resolution was 0.11km/s, the half power beamwidth (HPBW) is ~22", and the main beam efficiency (mb) is 0.65. Observations were made using the on-the-fly (OTF) mode with two orthogonal scan directions along RA and Dec. (J2000) centered on RA, Dec.(J2000)= (18:17:02.1, -18:40:19). We observed simultaneously the lines CO(3-2) (345.796GHz) and HCO+(4-3) (356.734) in a region of ~17'x17' (see Fig. 1). The spectra were reduced with NOSTAR2 using the standard procedure. The brightest star projected at the center of [BDS2003] 6 (2MASS J18165113-1841488) was observed on August 2016 with Astronomy Research using the Cornell Infra Red Imaging Spectrograph (ARCoIRIS), a cross-dispersed, single-object, longslit, infrared imaging spectrograph,mounted on Blanco 4-m Telescope, CTIO. The spectra cover a simultaneous wavelength range of 0.80 to 2.47um, at a spectral resolution of about 3500 λ{δλ, encompassing the entire zYJHK photometric range. The spectrum was taken with 480 sec integration time, at 1.03 average airmass. The HD163336 telluric A0 V standard is observed immediately after target. The basic steps of the reduction procedure are described in Chene et al. (2012A&A...545A..54C, Cat. J/A+A/545/A54, 2013A&A...549A..98C). We used the corresponding pipeline. (3 data files).

Evolução química de galáxias HII anãs

NASA Astrophysics Data System (ADS)

Ferraresi, M., Jr.; Cuisinier, F.; Telles, E.

2003-08-01

Galáxias HII anãs são galáxias de baixa massa, com alto conteúdo de gás, e se encontram em uma fase intensa de formação estelar. A taxa de formação estelar está tão alta nestas galáxias que não pode ter se mantido durante sua vida inteira. O tempo máximo de duração do episódio atual de formação estelar deve ser no máximo de algumas dezenas de milhões de anos, bem inferior à idade destas galáxias. Isto leva naturalmente a idéia de que já aconteceram surtos anteriores. Abundâncias químicas oferecem uma ferramenta poderosa para investigar a história evolutiva destas galáxias, porque aumentam de geração em geração estelar. O hidrogênio, o oxigênio, o nitrogênio produzem algumas das linhas mais importantes em um gás foto-ionizado, permitindo a determinação das abundâncias destes elementos facilmente. A dispersão das abundâncias em oxigênio e nitrogênio é significativa, sendo maior que os erros observacionais. O oxigênio é produzido em estrelas massivas, que explodem quase instâneamente, enquanto o nitrogênio é produzido em estrelas de massa intermediária, que só o liberam depois de um atraso de @ 500 mihões de anos. Construímos um modelo de evolução química semi-analítico, utilizando rendimentos empíricos baseados nas abundâncias observadas destes dois elementos. Conseguimos através deste modelo rudimentar explicar nas galáxias de mais baixas metalicidades as abundâncias de oxigênio e de nitrogênio, assim como a dispersão dos dados observacionais devida a formação estelar descontínua, e isto com um número baixo de surtos (1 ou 2, no máximo 3).

Molecular gas associated with IRAS 10361-5830

NASA Astrophysics Data System (ADS)

Vazzano, M. M.; Cappa, C. E.; Vasquez, J.; Rubio, M.; Romero, G. A.

2014-10-01

Aims: We analyze the distribution of the molecular gas and dust in the molecular clump linked to IRAS 10361-5830, located in the environs of the bubble-shaped Hii region Gum 31 in the Carina region, with the aim of determining the main parameters of the associated material and of investigating the evolutionary state of the young stellar objects identified there. Methods: Using the APEX telescope, we mapped the molecular emission in the J = 3-2 transition of three CO isotopologues, 12CO, 13CO and C18O, over a 1.´5 × 1.´5 region around the IRAS position. We also observed the high-density tracers CS and HCO+ toward the source. The cold- dust distribution was analyzed using submillimeter continuum data at 870 μm obtained with the APEX telescope. Complementary IR and radio data at different wavelengths were used to complete the study of the interstellar medium. Results: The molecular gas distribution reveals a cavity and a shell-like structure of ~0.32 pc in radius centered at the position of the IRAS source, with some young stellar objects projected onto the cavity. The total molecular mass in the shell and the mean H2volume density are ~40 M⊙ and ~(1-2) × 103 cm-3. The cold-dust counterpart of the molecular shell has been detected in the far-IR at 870 μm and in Herschel data at 350 μm. Weak extended emission at 24 μm from warm dust is projected onto the cavity, as well as weak radio continuum emission. Conclusions: A comparison of the distribution of cold and warm dust, and molecular and ionized gas allows us to conclude that a compact Hii region has developed in the molecular clump, indicating that this is an area of recent massive star formation. Probable exciting sources capable of creating the compact Hii region are investigated. The 2MASS source 10380461-5846233 (MSX G286.3773-00.2563) seems to be responsible for the formation of the Hii region. FITS files with datacubes corresponding to 12CO, 13CO, C180 maps are only available at the CDS via anonymous

Coupling XRD, EXAFS, and 13C NMR to study the effect of the carbon stoichiometry on the local structure of UC(1±x).

PubMed

Carvajal Nuñez, U; Martel, L; Prieur, D; Lopez Honorato, E; Eloirdi, R; Farnan, I; Vitova, T; Somers, J

2013-10-07

A series of uranium carbide samples, prepared by arc melting with a C/U ratio ranging from 0.96 to 1.04, has been studied by X-ray diffraction (XRD), (13)C nuclear magnetic resonance (NMR), and extended X-ray absorption fine structure (EXAFS). XRD determines phase uniqueness and the increase of the lattice parameter versus the carbon content. In contrast, (13)C NMR detects the different carbon environments in the lattice and in this study, clearly identifies the presence of discrete peaks for carbon in the octahedral lattice site in UC and an additional peak associated with excess carbon in hyperstoichiometric samples. Two peaks associated with different levels of carbon deficiency are detected for all hypostoichiometric compositions. More than one carbon environment is always detected by (13)C NMR. This exemplifies the difficulty in obtaining a perfect stoichiometric uranium monocarbide UC(1.00). The (13)C MAS spectra of uranium carbides exhibit the effects resulting from the carbon content on both the broadening of the peaks and on the Knight shift. An abrupt spectral change occurs between hypo- and hyperstoichiometric samples. The results obtained by EXAFS highlight subtle differences between the different stoichiometries, and in the hyperstoichiometric samples, the EXAFS results are consistent with the excess carbon atoms being in the tetrahedral interstitial position.

Geological and geomechanical properties of the carbonate rocks at the eastern Black Sea Region (NE Turkey)

NASA Astrophysics Data System (ADS)

Ersoy, Hakan; Yalçinalp, Bülent; Arslan, Mehmet; Babacan, Ali Erden; Çetiner, Gözde

2016-11-01

Turkey located in the Alpine-Himalayan Mountain Belt has 35% of the natural stone reserves of the world and has good quality marble, limestone, travertine and onyx reserves especially in the western regions of the country. The eastern Black Sea Region with a 1.4 million meters cubes reserve has a little role on the natural stone production in the country. For this reason, this paper deals with investigation on the potential of carbonate stone in the region and determination of the geological and geo-mechanical properties of these rocks in order to provide economic contribution to the national economy. While the study sites are selected among the all carbonate rock sites, the importance as well as the representative of the sites were carefully considered for the region. After representative samples were analyzed for major oxide and trace element compositions to find out petrochemical variations, the experimental program conducted on rock samples for determination of both physical and strength properties of the carbonate rocks. The results of the tests showed that there are significant variations in the geo-mechanical properties of the studied rock groups. The density values vary from 2.48 to 2.70 gr/cm3, water absorption by weight values range from 0.07 to 1.15% and the apparent porosity of the carbonate rocks are between 0.19 and 3.29%. However, the values of the UCS shows variation from 36 to 80 MPa. Tensile and bending strength values range from 3.2 to 7.5 MPa and 6.0-9.2 MPa respectively. Although the onyx samples have the lowest values of apparent porosity and water absorption by weight, these samples do not have the highest values of UCS values owing to occurrence of the micro-cracks. The UCS values of the rock samples were also found after cycling tests However, the limestone samples have less than 5% deterioration after freezing-thawing and wetting-drying tests, but travertine and onyx samples have more than 15% deterioration. Exception of the apparent

Performance of the Hack's Impairment Index Score: A Novel Tool to Assess Impairment from Alcohol in Emergency Department Patients.

PubMed

Hack, Jason B; Goldlust, Eric J; Ferrante, Dennis; Zink, Brian J

2017-10-01

Over 35 million alcohol-impaired (AI) patients are cared for in emergency departments (EDs) annually. Emergency physicians are charged with ensuring AI patients' safety by identifying resolution of alcohol-induced impairment. The most common standard evaluation is an extemporized clinical examination, as ethanol levels are not reliable or predictive of clinical symptoms. There is no standard assessment of ED AI patients. The objective was to evaluate a novel standardized ED assessment of alcohol impairment, Hack's Impairment Index (HII score), in a busy urban ED. A retrospective chart review was performed for all AI patients seen in our busy urban ED over 24 months. Trained nurses evaluated AI patients with both "usual" and HII score every 2 hours. Patients were stratified by frequency of visits for AI during this time: high (≥ 6), medium (2-5), and low (1). Within each category, comparisons were made between HII scores, measured ethanol levels, and usual nursing assessment of AI. Changes in HII scores over time were also evaluated. A total of 8,074 visits from 3,219 unique patients were eligible for study, including 7,973 (98.7%) with ethanol levels, 5,061 (62.7%) with complete HII scores, and 3,646 (45.2%) with health care provider assessments. Correlations between HII scores and ethanol levels were poor (Pearson's R 2  = 0.09, 0.09, and 0.17 for high-, medium-, and low-frequency strata). HII scores were excellent at discriminating nursing assessment of AI, while ethanol levels were less effective. Omitting extrema, HII scores fell consistently an average 0.062 points per hour, throughout patients' visits. The HII score applied a quantitative, objective assessment of alcohol impairment. HII scores were superior to ethanol levels as an objective clinical measure of impairment. The HII declines in a reasonably predictable manner over time, with serial evaluations corresponding well with health care provider evaluations. © 2017 by the Society for Academic

Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.

PubMed Central

Vakulenko, S B; Tóth, M; Taibi, P; Mobashery, S; Lerner, S A

1995-01-01

To examine the effect of disruption of the salt bridge (between Arg-164 and Asp-179 [numbering of Ambler et al. (Biochem J. 267:269-272, 1991)]) that anchors the conserved omega-loop in class A beta-lactamases, we obtained mutant enzymes with each of the 19 other amino acid residues replacing Asp-179 in the TEM beta-lactamase encoded by pUC19 and studied the level of resistance to various beta-lactams conferred by each enzyme. All mutations of Asp-179 compromised the level of resistance to ampicillin, but most of them enhanced resistance to ceftazidime. In contrast, mutations of Asp-179 generally impaired the low levels of resistance to cefepime and aztreonam. One might expect to find clinical isolates with mutant TEM beta-lactamases with replacements of Asp-179 that express an expanded spectrum of resistance to beta-lactams including ceftazidime. PMID:7486939

Study of the Optimum Zone of the Independent Variables of an ORGEL Reactor Connected to a 250-MWeb Power Plant. Self Supporting Fuel Elements Made of UC, with Sap Cladding with Four Fuel Rods and Individual Pressure Tubes; STUDIE DER OPTIMALEN ZONE DER UNABHANGIGEN PARAMETER EINES ORGEL- REAKTORS IN EINEM 250-MWe-KRAFTWERK. SELBST-TRAGENDES BRENNELEMENT AUS UC, SAP-UMHUL-LUNG MIT 4 BRENNSTOFFSTABEN UND INDIVIDUELLEN DRUCKROHREN

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFontaine, F.; Tauch, P.

The optimum range of the independent variables of and ORGEL reactor connected to a 250-Mw power plant (4 fuel rods of UC with individual pressure tubes), as well as the geometry of the reactor core and the operation of the plant, is described. (auth)

Solvation Dynamics in Different Phases of the Lyotropic Liquid Crystalline System.

PubMed

Roy, Bibhisan; Satpathi, Sagar; Gavvala, Krishna; Koninti, Raj Kumar; Hazra, Partha

2015-09-03

Reverse hexagonal (HII) liquid crystalline material based on glycerol monooleate (GMO) is considered as a potential carrier for drugs and other important biomolecules due to its thermotropic phase change and excellent morphology. In this work, the dynamics of encapsulated water, which plays important role in stabilization and formation of reverse hexagonal mesophase, has been investigated by time dependent Stokes shift method using Coumarin-343 as a solvation probe. The formation of the reverse hexagonal mesophase (HII) and transformation to the L2 phase have been monitored using small-angle X-ray scattering and polarized light microscopy experiments. REES studies suggest the existence of different polar regions in both HII and L2 systems. The solvation dynamics study inside the reverse hexagonal (HII) phase reveals the existence of two different types of water molecules exhibiting dynamics on a 120-900 ps time scale. The estimated diffusion coefficients of both types of water molecules obtained from the observed dynamics are in good agreement with the measured diffusion coefficient collected from the NMR study. The calculated activation energy is found to be 2.05 kcal/mol, which is associated with coupled rotational-translational water relaxation dynamics upon the transition from "bound" to "quasi-free" state. The observed ∼2 ns faster dynamics of the L2 phase compared to the HII phase may be associated with both the phase transformation as well as thermotropic effect on the relaxation process. Microviscosities calculated from time-resolved anisotropy studies infer that the interface is almost ∼22 times higher viscous than the central part of the cylinder. Overall, our results reveal the unique dynamical features of water inside the cylinder of reverse hexagonal and inverse micellar phases.

Enigmatic Extinction: An Investigation of the 2175Å Extinction Bump in M101

NASA Astrophysics Data System (ADS)

Danowski, Meredith E.; Cook, Timothy; Gordon, Karl D.; Chakrabarti, Supriya; Lawton, Brandon L.; Misselt, Karl A.

2014-06-01

Evidence from studies of starburst galaxies indicates that active formation of high mass stars modifies the UV dust extinction curve as seen by a lack of the characteristic 2175Å bump. For over 45 years, the source of the 2175Å extinction feature has yet to be positively identified. Small aromatic/PAH grains are suggested as a leading contender in dust grain models. The face-on spiral galaxy M101 is an ideal laboratory for the study of dust, with many well-studied HII regions and a steep metallicity and ionization gradient.The Interstellar Medium Absorption Gradient Experiment Rocket (IMAGER) probes the correlation between dust extinction, and the metallicity and radiation environment in M101 at ultraviolet wavelengths. IMAGER simultaneously images M101 in three 400Å-wide bandpasses, measuring the apparent strength of the 2175Å bump and the UV continuum.Combining data from IMAGER with high S/N far- and near- UV observations from the MAMA detectors on the Hubble STIS instrument, we examine the apparent strength of the 2175Å bump in HII regions of M101. With additional infrared data from Spitzer, the DIRTY radiative transfer model, and stellar evolution models, we probe the correlation between the 2175Å feature and the aromatic/PAH features across HII regions of varying metallicity and radiation field hardness. The results of this experiment will directly impact our understanding of the nature of dust and our ability to accurately account for the effects of dust on observations at all redshifts.

High mass star formation in the galaxy

NASA Technical Reports Server (NTRS)

Scoville, N. Z.; Good, J. C.

1987-01-01

The Galactic distributions of HI, H2, and HII regions are reviewed in order to elucidate the high mass star formation occurring in galactic spiral arms and in active galactic nuclei. Comparison of the large scale distributions of H2 gas and radio HII regions reveals that the rate of formation of OB stars depends on (n sub H2) sup 1.9 where (n sub H2) is the local mean density of H2 averaged over 300 pc scale lengths. In addition the efficiency of high mass star formation is a decreasing function of cloud mass in the range 200,000 to 3,000,000 solar mass. These results suggest that high mass star formation in the galactic disk is initiated by cloud-cloud collisions which are more frequent in the spiral arms due to orbit crowding. Cloud-cloud collisions may also be responsible for high rates of OB star formation in interacting galaxies and galactic nuclei. Based on analysis of the Infrared Astronomy Satellite (IRAS) and CO data for selected GMCs in the Galaxy, the ratio L sub IR/M sub H2 can be as high as 30 solar luminosity/solar mass for GMCs associated with HII regions. The L sub IR/M sub H2 ratios and dust temperature obtained in many of the high luminosity IRAS galaxies are similar to those encountered in galactic GMCs with OB star formation. High mass star formation is therefore a viable explanation for the high infrared luminosity of these galaxies.

Looking for high-mass young stellar objects: H2O and OH masers in ammonia cores

NASA Astrophysics Data System (ADS)

Codella, C.; Cesaroni, R.; López-Sepulcre, A.; Beltrán, M. T.; Furuya, R.; Testi, L.

2010-02-01

Context. The earliest stages of high-mass star formation have yet to be characterised well, because high-angular resolution observations are required to infer the properties of the molecular gas hosting the newly formed stars. Aims: We search for high-mass molecular cores in a large sample of 15 high-mass star-forming regions that are observed at high-angular resolution, extending a pilot survey based on a smaller number of objects. Methods: The sample was chosen from surveys of H2O and OH masers to favour the earliest phases of high-mass star formation. Each source was first observed with the 32-m single-dish Medicina antenna in the (1, 1) and (2, 2) inversion transitions at 1.3 cm of ammonia, which is an excellent tracer of dense gas. High-resolution maps in the NH3(2, 2) and (3, 3) lines and the 1.3 cm continuum were obtained successively with the VLA interferometer. Results: We detect continuum emission in almost all the observed star-forming regions, which corresponds to extended and UCHii regions created by young stellar objects with typical luminosities of ˜10^4~L⊙. However, only in three cases do we find a projected overlap between Hii regions and H2O and OH maser spots. On the other hand, the VLA images detect eight ammonia cores closely associated with the maser sources. The ammonia cores have sizes of ˜10^4 AU, and high masses (up to 104M⊙), and are very dense (from ˜10^6 to a few ×10^9 cm-3). The typical relative NH3 abundance is ≤10-7, in agreement with previous measurements in high-mass star-forming regions. Conclusions: The statistical analysis of the distribution between H2O and OH masers, NH3 cores, and Hii regions confirms that the earliest stages of high-mass star formation are characterised by high-density molecular cores with temperatures of on average ≥30 K, either without a detectable ionised region or associated with a hypercompact Hii region.

Effect of benzene, toluene, ethylbenzene, and p-xylene (BTEX) mixture on biodegradation of methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA) by pure culture UC1.

PubMed

Pruden, Amy; Suidan, Makram

2004-08-01

The effect of a BTEX mixture on the biodegradation of methyl tert-butyl ether (MTBE) and its degradation intermediate, tert-butyl alcohol (TBA) was investigated in the pure bacterial culture UC1, which has been identified to be a strain of the known MTBE-degrader PM1 based on greater than 99% 16S rDNA similarity. Several degradation studies were carried out on UC1 at three initial concentration levels of MTBE or TBA: 6-7; 15-17; and 40-45 mg/l, both with and without BTEX present cumulatively at about half of the MTBE or TBA molar mass in the system. The BTEX mixture was observed not to affect either the rate or the degradation lag period of MTBE or TBA degradation, except that the TBA degradation rate actually increased when BTEX was present initially in the highest concentration studies. When serving as the sole substrate, the MTBE degradation rate ranged from 48 +/- 1.2 to 200 +/- 7.0 mg(MTBE)/g(dw) h, and the TBA degradation rate from 140 +/- 18 to 530 +/- 70 mg(TBA)/g(dw) h. When present with BTEX, MTBE and TBA rates ranged from 46 +/- 2.2 to 210 +/- 14 and 170 +/- 28 to 780 +/- 43 mg(TBA)/g(dw) h, respectively. In studies where varying concentrations of TBA were present with 5 mg/l MTBE, both compounds were degraded simultaneously with no obvious preference for either substrate. In the highest concentration study of TBA with 5 mg/l MTBE, BTEX was also observed to increase the ultimate rate of TBA degradation. In addition to exploring the affect of BTEX, this study also provides general insight into the metabolism of MTBE and TBA by pure culture UC1.

Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis.

PubMed

Nomura, E; Kinouchi, Y; Negoro, K; Kojima, Y; Oomori, S; Sugimura, M; Hiroki, M; Takagi, S; Aihara, H; Takahashi, S; Hiwatashi, N; Shimosegawa, T

2004-09-01

Ulcerative colitis (UC) is a multifactorial disorder with both genetic and environmental factors. HLA-B*52 and DRB1*1502 are reported to be strongly associated with UC in Japan. However, the actual susceptible gene has not been identified yet. In this study, to map precisely the susceptible locus for UC, we performed association mapping in the chromosome 6p using 24 microsatellite markers distributed over 16 Mb. A total of 183 patients with UC and 186 healthy controls (HC) were included in this study. In all, 15 markers around the human leukocyte antigen (HLA) region showed statistical significance in the genotypic differentiation test concerned with the allelic distribution between the UC and HC. Especially, the markers between the centromeric region of HLA class I and the telomeric region of class III showed remarkably low P-values and the allele239 of C2-4-4 in class I marker showed the strongest association (Pc=2.9 x 10(-9): OR=3.74, 95% CI=2.50-5.60). Furthermore, we found strong linkage disequilibrium (LD) between the allele239 of C2-4-4 and HLA-B*52 in haplotype analysis. These results provide evidence that, in Japanese, important determinants of disease susceptibility to UC may exist in HLA, especially between the centromeric region of class I and the telomeric region of class III, under the strong LD with HLA-B*52.

Inverted micellar intermediates and the transitions between lamellar, cubic, and inverted hexagonal lipid phases. II. Implications for membrane-membrane interactions and membrane fusion.

PubMed Central

Siegel, D P

1986-01-01

Results of a kinetic model of thermotropic L alpha----HII phase transitions are used to predict the types and order-of-magnitude rates of interactions between unilamellar vesicles that can occur by intermediates in the L alpha----HII phase transition. These interactions are: outer monolayer lipid exchange between vesicles; vesicle leakage subsequent to aggregation; and (only in systems with ratios of L alpha and HII phase structural dimensions in a certain range or with unusually large bilayer lateral compressibilities) vesicle fusion with retention of contents. It was previously proposed that inverted micellar structures mediate membrane fusion. These inverted micellar structures are thought to form in all systems with such transitions. However, I show that membrane fusion probably occurs via structures that form from these inverted micellar intermediates, and that fusion should occur in only a sub-set of lipid systems that can adopt the HII phase. For single-component phosphatidylethanolamine (PE) systems with thermotropic L alpha----HII transitions, lipid exchange should be observed starting at temperatures several degrees below TH and at all higher temperatures, where TH is the L alpha----HII transition temperature. At temperatures above TH, the HII phase forms between apposed vesicles, and eventually ruptures them (leakage). In most single-component PE systems, fusion via L alpha----HII transition intermediates should not occur. This is the behavior observed by Bentz, Ellens, Lai, Szoka, et al. in PE vesicle systems. Fusion is likely to occur under circumstances in which multilamellar samples of lipid form the so-called "inverted cubic" or "isotropic" phase. This is as observed in the mono-methyl DOPE system (Ellens, H., J. Bentz, and F. C. Szoka. 1986. Fusion of phosphatidylethanolamine containing liposomes and the mechanism of the L alpha-HII phase transition. Biochemistry. In press.) In lipid systems with L alpha----HII transitions driven by cation binding

NGC 3503 and its molecular environment

NASA Astrophysics Data System (ADS)

Duronea, N. U.; Vasquez, J.; Cappa, C. E.; Corti, M.; Arnal, E. M.

2012-01-01

Aims: We present a study of the molecular gas and interstellar dust distribution in the environs of the Hii region NGC 3503 associated with the open cluster Pis 17 with the aim of investigating the spatial distribution of the molecular gas linked to the nebula and achieving a better understanding of the interaction of the nebula and Pis 17 with their molecular environment. Methods: We based our study on 12CO(1-0) observations of a region of ~0.6° in size obtained with the 4-m NANTEN telescope, unpublished radio continuum data at 4800 and 8640 MHz obtained with the ATCA telescope, radio continuum data at 843 MHz obtained from SUMSS, and available IRAS, MSX, IRAC-GLIMPSE, and MIPSGAL images. Results: We found a molecular cloud (Component 1) having a mean velocity of -24.7 km s-1 ,compatible with the velocity of the ionized gas, which is associated with the nebula and its surroundings. Adopting a distance of 2.9 ± 0.4 kpc, the total molecular mass yields (7.6 ± 2.1) × 103M⊙ and density yields 400 ± 240 cm-3. The radio continuum data confirm the existence of an electron density gradient in NGC 3503. The IR emission shows a PDR bordering the higher density regions of the nebula. The spatial distribution of the CO emission shows that the nebula coincides with a molecular clump, and the strongest CO emission peak is located close to the higher electron density region. The more negative velocities of the molecular gas (about -27 km s-1), are coincident with NGC 3503. Candidate young stellar objects (YSOs) were detected toward the Hii region, suggesting that embedded star formation may be occurring in the neighborhood of the nebula. The clear electron density gradient, along with the spatial distribution of the molecular gas and PAHs in the region indicates that NGC 3503 is a blister-type Hii region that has probably undergone a champagne phase.

Balloon observations of galactic and extragalactic objects at 100 microns.

NASA Technical Reports Server (NTRS)

Hoffmann, W. F.

1972-01-01

Recent far-infrared balloon-borne instruments have yielded observations of a number of bright sources at 100 microns. Many of these coincide with HII regions where molecular line emision has been detected. There is some indication of 100 micron emission which does not coincide with radio measurements.

VizieR Online Data Catalog: Distance-limited sample of MYSOs (Maud+, 2015)

NASA Astrophysics Data System (ADS)

Maud, L. T.; Lumsden, S. L.; Moore, T. J. T.; Mottram, J. C.; Urquhart, J. S.; Cicchini, A.

2016-01-01

The sources were chosen from all MYSOs and HII regions in the RMS survey that are located within a distance of ~6kpc, have luminosities >~3000 L{sun}, and are observable with the James Clerk Maxwell Telescope (JCMT; declinations -25° to +65°), with some additional right ascension constraints set by the observing dates. In addition, for the HII regions, only those sources which appear compact in higher resolution mid-IR images were selected. Finally although all of the sources with L>10000L{sun} were observed, only a random sample of the less luminous ones were included All 99 sources were observed with the JCMT as part of projects M07AU08, M07BU16, M08AU19 and M08BU18 during 2007 and 2008. The 15m dish yields a full-width at half-maximum (FWHM) beam size of 15.3-arcsec at ~329GHz for the C18O (3-2) line. (4 data files).

IRAS01202+6133: A Possible Case of Protostellar Collapse Triggered by a Small HIIRegion

NASA Astrophysics Data System (ADS)

Kang, Sung-Ju; Kerton, C.

2012-01-01

The molecular gas surrounding an HII region is thought to be a place where star formation can be induced. One of the main questions in the study of star formation is how protostars accrete material from their parent molecular clouds and observations of infall motions are needed to provide direct evidence for accretion. This poster will present an analysis of submm spectroscopic observations of the submm/infrared source IRAS 01202+6133 located on the periphery of the HII region KR 120. HCO+(J=3-2) spectra of this source show a classic blue-dominated double-peaked profile indicative of infall motions that would be expected to occur in the envelope surrounding a young protostellar object. The HCO+ spectrum toward the core was fitted using models incorporating both outflow and infall components along with basic assumptions regarding excitation temperature trends within molecular cloud cores. Using the models, we derive physical properties of the infall kinematics and the envelope structure.

Deep optical survey of the stellar content of Sh2-311 region

NASA Astrophysics Data System (ADS)

Yadav, Ram Kesh; Pandey, A. K.; Sharma, Saurabh; Jose, J.; Ogura, K.; Kobayashi, N.; Samal, M. R.; Eswaraiah, C.; Chandola, H. C.

2015-01-01

The stellar content in and around Sh2-311 region have been studied using the deep optical observations as well as near-infrared (NIR) data from 2MASS. The region contains three clusters, viz. NGC 2467, Haffner 18 and Haffner 19. We have made an attempt to distinguish the stellar content of these individual regions as well as to re-determine their fundamental parameters such as distance, reddening, age, onto the basis of a new and more extended optical and infrared photometric data set. NGC 2467 and Haffner 19 are found to be located in the Perseus arm at the distances of 5.0 ± 0.4 kpc and 5.7 ± 0.4 kpc, respectively, whereas Haffner 18 is located at the distance of 11.2 ± 1.0 kpc. The clusters NGC 2467 and Haffner 19 might have formed from the same molecular cloud, whereas the cluster Haffner 18 is located in the outer galactic arm, i.e. the Norma-Cygnus arm. We identify 8 class II young stellar objects (YSOs) using the NIR (J-H)/(H-K) two colour diagram. We have estimated the age and mass of the YSOs identified in the present work and those by Snider et al. (2009) using the V/(V-I) colour-magnitude diagram. The estimated ages and mass range of the majority of the YSOs are ≲1 Myr and ∼0.4-3.5 M⊙, respectively, indicating that these sources could be T-Tauri stars or their siblings. Spatial distribution of the YSOs shows that some of the YSOs are distributed around the HII region Sh2-311, suggesting a triggered star formation at its periphery.

BVRI photometry of ASASSN-15qi using the Tautenburg Schmidt telescope

NASA Astrophysics Data System (ADS)

Stecklum, Bringfried; Eisloeffel, Jochen; Scholz, Alexander

2015-10-01

We report on photometric observations of the optical transient ASASSN-15qi performed at the Th & uuml;ringer Landessternwarte Tautenburg. The brightening of this source was discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN, Shappee et al. 2014, ApJ, 788, 48). The object is located west of the HII region SH2-148 and a likely member of the star forming region.

A Survey of Large Molecules toward the Protoplanetary Nebula CRL 61 8

NASA Technical Reports Server (NTRS)

Remijan, Anthony J.; Wyrowski, Friedrich; Friedel, Douglas N.; Meier, David S.; Snyder, Lewis E.

2005-01-01

We present the results of our survey toward the protoplanetary nebula CRL 618 for several large, highly saturated, oxygen bearing organic molecules of biological importance including acetaldehyde (CH3CHO), acetic acid (CH3OOH), dimethyl ether (CH3OCH3), ethanol (CH3CH2OH), formic acid (HCOOH) and methyl formate (HCOOCH3); large carbon chain molecules including methyl cyanide (CH3CN) , methylcyanoacetylene (CH3C3N), cyanoacetylene (HC3N), cyanodiacetylene (HC5N), and C6H; and finally smaller molecules including SO-34, SO2, O(C-34)S and MgNC. No biologically important organic molecules were detected. However, we report the first interferometric detections of CH3CN and vibrationally excited HC3N and HC5N toward this source. The temperature and distribution of CH3CN toward CRL 618 indicates it is formed in the outer envelope surrounding the UC HII region. Furthermore, the P-Cygni line profile and corresponding channel maps of vibrationally excited HC5N supports its distribution in the extended envelope expanding radially from the central star. The detection of vibrationally excited HC3N confirmed the temperature structure and column density of HC3N in the inner envelope found by Wyrowski and colleagues (2003). Finally, our observations clearly indicate that CRL 618 is a good source of large carbon chain species but is a very poor source to detect or produce organic species of biological importance.

A new supernova remnant candidate in the UWIFE [Fe II] line survey

NASA Astrophysics Data System (ADS)

Kim, Yesol; Koo, Bon-Chul

2016-06-01

We report the discovery of a new supernova remnant (SNR) candidate in the narrow-band [Fe II] 1.644 um line imaging survey UWIFE (UKIRT Widefield Infrared Survey for Fe). UWIFE covers the first quadrant of the Galactic plane (7degrees < l < 62degrees, |b| < 1.5degrees), and, by visual inspection, we have found ~300 extended Ionized Fe objects (IFOs) in the survey area. Most of IFOs are associated with SNRs, young stellar objects, HII regions, and planetary nebulae. But about 12% of IFOs are not associated with any known astronomical objects, and the SNR candidate, IFO J183740.829-061452.41 (hereafter IFO J183740) is one of those. IFO J183740 is a 6`-long, faint, arc-like filament with small-scale irregular structures. It appears to be a portion of a circular loop, but the rest of the loop is not seen in [Fe II] emission. It is found to coincide with a well-defined radio continuum arc. The radio arc has a complicated morphology, and IFO J183740 coincides with the bright inner part of the radio arc. Hydrogen recombination lines have been detected toward the radio arc from low-resolution surveys, so it has been known as an HII region (G25.8+0.2) at a kinematic distance of 6.5 kpc. But the inside of this radio arc is filled with soft X-rays, while, just outside the arc to the north, there is hard X-ray nebula harboring a young pulsar. Therefore, the nature of this arc-like structure seen in radio and [Fe II] emission is uncertain. In this presentation, we present the results of follow-up spectroscopic study of IFO J183740 using IGRINS (Immersion Grating Infrared Spectrograph) which is high spectral resolution (R~40,000) spectrograph covering H and K-bands, simultaneously. We have found that the [Fe II] filaments are both spatially and kinematically distinct from the HII filaments. The intensity ratios of [Fe II] to Brγ lines suggest that the HII filaments are photoionized while the [Fe II] filaments are shock-ionized, which supports the SNR origin for IFO J183740. We

Deriving the pattern speed using dynamical modelling of gas flows in barred galaxies .

NASA Astrophysics Data System (ADS)

Pérez, I.; Freeman, K. C.; Fux, R.; Zurita, A.

In this paper we analyse the methodology to derive the bar pattern speed from dynamical simulations. The results are robust to the changes in the vertical-scale height and in the mass-to-light (M/L) ratios. There is a small range of parameters for which the kinematics can be fitted. We have also taken into account the use of different type of dynamical modelling and the effect of using 2-D vs 1-D models in deriving the pattern speeds. We conclude that the derivation of the bar streaming motions and strength and position of shocks is not greatly affected by the fluid dynamical model used. We show new results on the derivation of the pattern speed for NGC 1530. The best fit pattern speed is around 10 km s-1 kpc-1 , which corresponds to a R_cor/R_bar = 1.4, implying a slower bar than previously derived from more indirect assumptions. With this pattern speed, the global and most local kinematic features are beautifully reproduced. However, the simulations fail to reproduce the velocity gradients close to some bright HII regions in the bar. We have shown from the study of the H{alpha } equivalent widths that the HII regions that are located further away from the bar dust-lane in its leading side, downstream from the main bar dust-lane, are older than the rest by 1.5-2.5 Myr. In addition, a clear spatial correlation was found between the location of HII regions, dust spurs on the trailing side of the bar dust-lane, and the loci of maximum velocity gradients parallel to the bar major axis.

Addressing Ionization and Depletion in the ISM of Nearby Star-Forming Galaxies

NASA Astrophysics Data System (ADS)

Aloisi, Alessandra

2017-08-01

Measuring galaxy metallicity with cosmic time is of paramount importance to understand galaxy formation. ISM abundances are typically determined using emission-line spectroscopy of HII regions. However, HII regions may be self-enriched and not typical of the whole galaxy. This is particularly true for star-forming galaxies (SFGs) where the bulk of metals may be in the neutral gas. Quantifying metals in the ISM is thus important to assess how reliably HII regions trace galaxy abundances at any redshift. We were awarded 34 HST orbits (Cycle 17) to measure abundances in the neutral ISM of 9 nearby SFGs using absorption lines in the COS G130M/1291 spectra of bright UV background sources within the galaxy itself. We found metallicities that differ by up to 2 dex depending on the element. These variations could be real or due to observational effects. Here we request 22 orbits in the new G130M/1222 and in G160M/1623 to access new FUV spectral transitions that will help us characterize ionized-gas contamination and dust depletion, and ultimately nail down the abundances of the different elements. These new data will nicely complement our Cycle 17 COS and Gemini/GMOS IFU programs, the latter aimed at deriving nebular abundances along the same COS sightlines. This first detailed and spatially-accurate comparison between neutral- and ionized-gas abundances in local (z 0) SFGs will provide crucial insights into the metallicity of galaxies at any redshift. If this UV spectroscopic study is not undertaken before HST ceases operation, the (in)homogeneity of the ISM in galaxies of the local Universe will continue to remain uncertain for at least another decade.

Database of emission lines

NASA Astrophysics Data System (ADS)

Binette, L.; Ortiz, P.; Joguet, B.; Rola, C.

1998-11-01

A widely accessible data bank (available through Netscape) and consiting of all (or most) of the emission lines reported in the litterature is being built. It will comprise objects as diverse as HII regions, PN, AGN, HHO. One of its use will be to define/refine existing diagnostic emission line diagrams.

VizieR Online Data Catalog: Spectrophotometric distances of HII regions (Moises+, 2011)

NASA Astrophysics Data System (ADS)

Moises, A. P.; Damineli, A.; Figueredo, E.; Blum, R. D.; Conti, P. S.; Barbosa, C. L.

2011-11-01

The J-band (λ1.28um, δλ=0.3um), H-band (λ1.63um, δλ=0.3um) and Ks-band (λ2.19um, δλ=0.4um) images were obtained on the nights of 1999 May 1, 4 and 20, 2000 May 19 and 21 and 2001 July 10 and 12, at the Cerro Tololo Inter-American Observatory (CTIO) 4-m Blanco telescope, using the facility's infrared imager OSIRIS, which has a field of view (FOV) of 93x93arcsec2 and a pixel scale of 0.161arcsec/pixel. On the nights of 2005 Jult 3-6 and 11 and 2006 June 3-7, we obtained images using the facility's infrared imager ISPI (with a FOV of 10.25x10.25arcmin2 and a pixel scale of 0.3arcsec/pix), also at the 4-m Blanco telescope. Also, on the nights of 1998 August 28 and 29, we obtained images on the CTIO 4-m telescope using the facility's infrared imager CIRIM (with a FOV of 102x102arcsec2 and a pixel scale of 0.40arcsec/pix). (3 data files).

Colin Gum and the discovery of the Gum nebula

NASA Technical Reports Server (NTRS)

Kerr, F. J.

1971-01-01

The research of Colin Gum in the field of astronomy is reviewed. It includes a radio survey at 200 MHz, a photographic survey for HII regions in the Southern Milky Way from longitude 220 deg to 20 deg, and a catalogue of 85 physically separate regions. He suggested that certain faint nebulosities were part of a large, nearby H II region excited by gamma Velorum and zeta Puppis. He was also concerned with 21-cm studies.

Activation Energy of the Low-pH-Induced Lamellar to Bicontinuous Cubic Phase Transition in Dioleoylphosphatidylserine/Monoolein.

PubMed

Oka, Toshihiko; Saiki, Takahiro; Alam, Jahangir Md; Yamazaki, Masahito

2016-02-09

Electrostatic interaction is an important factor for phase transitions between lamellar liquid-crystalline (Lα) and inverse bicontinuous cubic (QII) phases. We investigated the effect of temperature on the low-pH-induced Lα to double-diamond cubic (QII(D)) phase transition in dioleoylphosphatidylserine (DOPS)/monoolein (MO) using time-resolved small-angle X-ray scattering with a stopped-flow apparatus. Under all conditions of temperature and pH, the Lα phase was directly transformed into an intermediate inverse hexagonal (HII) phase, and subsequently the HII phase slowly converted to the QII(D) phase. We obtained the rate constants of the initial step (i.e., the Lα to HII phase transition) and of the second step (i.e., the HII to QII(D) phase transition) using the non-negative matrix factorization method. The rate constant of the initial step increased with temperature. By analyzing this result, we obtained the values of its apparent activation energy, Ea (Lα → HII), which did not change with temperature but increased with an increase in pH. In contrast, the rate constant of the second step decreased with temperature at pH 2.6, although it increased with temperature at pH 2.7 and 2.8. These results indicate that the value of Ea (HII → QII(D)) at pH 2.6 increased with temperature, but the values of Ea (HII → QII(D)) at pH 2.7 and 2.8 were constant with temperature. The values of Ea (HII → QII(D)) were smaller than those of Ea (Lα → HII) at the same pH. We analyzed these results using a modified quantitative theory on the activation energy of phase transitions of lipid membranes proposed initially by Squires et al. (Squires, A. M.; Conn, C. E.; Seddon, J. M.; Templer, R. H. Soft Matter 2009, 5, 4773). On the basis of these results, we discuss the mechanism of this phase transition.

A distância e o conteúdo estelar da região HII gigante G333.1-0.4 - vínculos para a taxa de formação estelar da galáxia

NASA Astrophysics Data System (ADS)

Figuerêdo, E.; Damineli, A.; Blum, R.; Conti, P.

2003-08-01

Neste trabalho apresentamos imagens de alta resolução angular da região HII gigante G333.1-0.4 obtidas através dos filtros J, H e K no telescópio de 4-m do CTIO. Este trabalho faz parte de um estudo de regiões HII gigantes no infravermelho próximo que tem por objetivo estudar a natureza da formação de estrelas massivas e traçar a estrutura espiral de nossa galáxia. Nossa determinação da distância é baseada no método da paralaxe espectroscópica de estrelas OB localizadas na seqüência principal de idade zero (ZAMS) do Diagrama HR. No caso de G333.1-0.4, a magnitude aparente das estrelas localizadas na ZAMS indica que a distância não pode ser maior do que o limite inferior determinado por técnica rádio (2,8 kpc). Resultados semelhantes foram encontrados para regiões estudadas anteriormente, reforçando a idéia de que a taxa de formação estelar na Via Láctea é menor do que o determinado a partir de dados rádio. Nossos resultados mais recentes sobre o conteúdo estelar de G333.1-0.4 revelaram vários objetos que possuem cores bastante avermelhadas (H-K > 2,0). Nós identificamos estes objetos usando os diagramas cor-cor e cor-magnitude dos aglomerados. Estes objetos apresentam um forte excesso em emissão na banda K e possivelmente se tratam de estrelas do tipo OB envolvidas por um disco/envelope circumestelar espesso. O estudo da função de massa inical desta região, em conjunto com resultados de nossos trabalhos anteriores, aponta para uma IMF independente da posição galática. A contagem de estrelas nos fornece um valor para o número de fótons no contínuo de Lyman que corrobora com a afirmação de que G333.1-0.4 se encontra mais próxima da menor distância determinada por rádio.

Investigation of Crohn’s Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

PubMed Central

ANDERSON, CARL A.; MASSEY, DUNECAN C. O.; BARRETT, JEFFREY C.; PRESCOTT, NATALIE J.; TREMELLING, MARK; FISHER, SHEILA A.; GWILLIAM, RHIAN; JACOB, JEMIMA; NIMMO, ELAINE R.; DRUMMOND, HAZEL; LEES, CHARLIE W.; ONNIE, CLIVE M.; HANSON, CATHERINE; BLASZCZYK, KATARZYNA; RAVINDRARAJAH, RADHI; HUNT, SARAH; VARMA, DHIRAJ; HAMMOND, NAOMI; LEWIS, GREGORY; ATTLESEY, HEATHER; WATKINS, NICK; OUWEHAND, WILLEM; STRACHAN, DAVID; MCARDLE, WENDY; LEWIS, CATHRYN M.; LOBO, ALAN; SANDERSON, JEREMY; JEWELL, DEREK P.; DELOUKAS, PANOS; MANSFIELD, JOHN C.; MATHEW, CHRISTOPHER G.; SATSANGI, JACK; PARKES, MILES

2009-01-01

Background & Aims Identifying shared and disease-specific susceptibility loci for Crohn’s disease (CD) and ulcerative colitis (UC) would help define the biologic relationship between the inflammatory bowel diseases. More than 30 CD susceptibility loci have been identified. These represent important candidate susceptibility loci for UC. Loci discovered by the index genome scans in CD have previously been tested for association with UC, but those identified in the recent meta-analysis await such investigation. Furthermore, the recently identified UC locus at ECM1 requires formal testing for association with CD. Methods We analyzed 45 single nucleotide polymorphisms, tagging 29 of the loci recently associated with CD in 2527 UC cases and 4070 population controls. We also genotyped the UC-associated ECM1 variant rs11205387 in 1560 CD patients and 3028 controls. Results Nine regions showed association with UC at a threshold corrected for the 29 loci tested (P < .0017). The strongest association (P = 4.13 × 10-8; odds ratio = 1.27) was identified with a 170-kilobase region on chromosome 1q32 that contains 3 genes. We also found association with JAK2 and replicated a recently reported association with STAT3, further implicating the role of this signaling pathway in inflammatory bowel disease. Additional novel UC susceptibility genes were LYRM4 and CDKAL1. Twenty of the loci were not associated with UC, and several appear to be specific to CD. ECM1 variation was not associated with CD. Conclusions Collectively, these data help define the genetic relationship between CD and UC and characterize common, as well as disease-specific mechanisms of pathogenesis. PMID:19068216

Photochemical methods to assay DNA photocleavage using supercoiled pUC18 DNA and LED or xenon arc lamp excitation.

PubMed

Prussin, Aaron J; Zigler, David F; Jain, Avijita; Brown, Jared R; Winkel, Brenda S J; Brewer, Karen J

2008-04-01

Methods for the study of DNA photocleavage are illustrated using a mixed-metal supramolecular complex [{(bpy)(2)Ru(dpp)}(2)RhCl(2)]Cl(5). The methods use supercoiled pUC18 plasmid as a DNA probe and either filtered light from a xenon arc lamp source or monochromatic light from a newly designed, high-intensity light-emitting diode (LED) array. Detailed methods for performing the photochemical experiments and analysis of the DNA photoproduct are delineated. Detailed methods are also given for building an LED array to be used for DNA photolysis experiments. The Xe arc source has a broad spectral range and high light flux. The LEDs have a high-intensity, nearly monochromatic output. Arrays of LEDs have the advantage of allowing tunable, accurate output to multiple samples for high-throughput photochemistry experiments at relatively low cost.

ALMA view of the massive dense clump in the Galactic center 50 km s-1 molecular cloud .

NASA Astrophysics Data System (ADS)

Uehara, K.; Tsuboi, M.; Kitamura, Y.; Miyawaki, R.; Miyazaki, A.

We observed the 50 km s-1 molecular cloud with a high angular resolution (˜1.5 arcsec) using ALMA in the H13CO+ J=1-0, C34S J=2-1, CS J=2-1 and SiO v=0 J=2-1 emission lines. This cloud is a candidate for the massive star forming region induced by cloud-cloud collision (CCC). We newly found a massive dense clump (DC1) with a size of ˜0.3 pc in the CCC region of the cloud in the H13CO+ J=1-0 map. The DC1 seems to be located on a line where the four HII regions line up. Furthermore, the DC1 has a broad velocity width covering ˜30 km s-1 and ˜60 km s-1 components in the CS J=2-1 map; the 30 km s-1 component has filamentary structures and the 60 km s-1 one a sheet-like structure. From the position-velocity diagrams of the H13CO+ J=1-0 and CS J=2-1 lines and the intensity ratio of T(SiO v=0 J=2-1)/T(H13CO+ J=1-0), i.e., a shock tracer, we consider that the DC1 has formed by the CCC between the filaments and the sheet-like gas. The LTE mass and virial parameter of the DC1 is estimated to be ˜1.3×104 M_ȯ and ˜5, respectively. These facts suggest that the DC1 is likely in a gravitationally bound state and may start massive star formation. We propose a scenario that the CCC induced the massive star formation in the HII region A ˜105 years ago and now causes the formation and collapse of the DC1; the clump would evolve to an HII region within ˜105 years.

Developing a standardized measurement of alcohol intoxication.

PubMed

Benoit, Justin L; Hart, Kimberly W; Soliman, Adam A; Barczak, Christopher M; Sibilia, Robert S; Lindsell, Christopher J; Fermann, Gregory J

2017-05-01

We assessed multiple examinations and assessment tools to develop a standardized measurement of alcohol intoxication to aid medical decision making in the Emergency Department. Volunteers underwent an alcohol challenge. Pre- and post-alcohol challenge, subjects were videotaped performing three standardized clinical examinations: (1) Standardized Field Sobriety Test (SFST) examination, (2) Hack's Impairment Index (HII) examination, and (3) Cincinnati Intoxication Examination (CIE). Emergency clinicians evaluated the level of intoxication using five standardized assessment tools in a blinded and randomized fashion: (1) SFST assessment tool (range 0-18), (2) HII assessment tool (range 0-1), (3) St. Elizabeth Alcohol Intoxication Scale (STE, range 0-17), (4) a Visual Analog Scale (VAS, range 0-100), and (5) a Binary Intoxication Question (BIQ). Construct validity was assessed along with inter- and intra-rater reliability. Median scores pre- and post-alcohol challenge were: SFST 6 (interquartile range 5) and 11 (3), respectively; HII 0 (0.05), 0.1 (0.1); STE 0 (1), 1 (2); VAS 10 (22), 33 (31). For BIQ, 59% and 91% indicated intoxication, respectively. Inter-rater reliability scores were: SFST 0.71 (95% confidence interval 0.48-0.86) to 0.93 (0.88-0.97) depending on examination component; HII 0.90 (0.82-0.95); STE 0.86 (0.75-0.93); VAS 0.92 (0.88-0.94); BIQ 0.3. Intra-rater reliability scores were: SFST 0.74 (0.64-0.82) to 0.87 (0.81-0.91); HII 0.85 (0.79-0.90); STE 0.78 (0.68-0.85); VAS 0.82 (0.74-0.87); BIQ 0.71. VAS reliability was best when paired with the HII and SFST examinations. HII examination, paired with either a VAS or HII assessment tool, yielded valid and reliable measurements of alcohol intoxication. Copyright © 2017 Elsevier Inc. All rights reserved.

VizieR Online Data Catalog: Diffuse ionized gas database DIGEDA (Flores-Fajardo+ 2009)

NASA Astrophysics Data System (ADS)

Flores-Fajardo, N.; Morisset, C.; Binette, L.

2009-09-01

DIGEDA is a comprehensive database comprising 1061 DIG and HII region spectroscopic observations of 29 different galaxies (25 spiral galaxies and 4 irregulars) from 18 bibliographic references. This survey contains galaxies with significant spread in star formation rates, Halpha luminosities, distances, disk inclinations, slit positions and slit orientations. The 1061 observations obtained from these references were extracted by digitalization of published figures or tables. The data were subsequently normalized and incorporated in DIGEDA. This resulted in a table of 26 columns containing 1061 data lines or records (DIGEDA.dat file). We have not performed any reddening by dust correction or for the presence of underlying absorption lines, although we did use the reddening corrected ratios when made available by the authors. Missing entries are represented by (-1) in the corresponding data field. In DIGEDA the observed areas are classificated in three possible emission region types: HII region, transition zones or DIG. When this classification was not reported (no matter the criterion) for the authors, we introduce our own classification taking into account the value of |z| as described in the paper. (4 data files).

The Galactic Distribution of Massive Star Formation from the Red MSX Source Survey

NASA Astrophysics Data System (ADS)

Figura, Charles C.; Urquhart, J. S.

2013-01-01

Massive stars inject enormous amounts of energy into their environments in the form of UV radiation and molecular outflows, creating HII regions and enriching local chemistry. These effects provide feedback mechanisms that aid in regulating star formation in the region, and may trigger the formation of subsequent generations of stars. Understanding the mechanics of massive star formation presents an important key to understanding this process and its role in shaping the dynamics of galactic structure. The Red MSX Source (RMS) survey is a multi-wavelength investigation of ~1200 massive young stellar objects (MYSO) and ultra-compact HII (UCHII) regions identified from a sample of colour-selected sources from the Midcourse Space Experiment (MSX) point source catalog and Two Micron All Sky Survey. We present a study of over 900 MYSO and UCHII regions investigated by the RMS survey. We review the methods used to determine distances, and investigate the radial galactocentric distribution of these sources in context with the observed structure of the galaxy. The distribution of MYSO and UCHII regions is found to be spatially correlated with the spiral arms and galactic bar. We examine the radial distribution of MYSOs and UCHII regions and find variations in the star formation rate between the inner and outer Galaxy and discuss the implications for star formation throughout the galactic disc.

Report on the Program "Fluid-mediated particle transport in geophysical flows" at the Kavli Institute for Theoretical Physics, UC Santa Barbara, September 23 to December 12, 2013

NASA Astrophysics Data System (ADS)

Jenkins, James T.; Meiburg, Eckart; Valance, Alexandre

2015-09-01

The Kavli Institute of Theoretical Physics (KITP) program held at UC Santa Barbara in the fall of 2013 addressed the dynamics of dispersed particulate flows in the environment. By focusing on the prototypes of aeolian transport and turbidity currents, it aimed to establish the current state of our understanding of such two-phase flows, to identify key open questions, and to develop collaborative research strategies for addressing these questions. Here, we provide a brief summary of the program outcome.

Characterization and Mapping of Leaf Rust and Stripe Rust Resistance Loci in Hexaploid Wheat Lines UC1110 and PI610750 under Mexican Environments.

PubMed

Lan, Caixia; Hale, Iago L; Herrera-Foessel, Sybil A; Basnet, Bhoja R; Randhawa, Mandeep S; Huerta-Espino, Julio; Dubcovsky, Jorge; Singh, Ravi P

2017-01-01

Growing resistant wheat varieties is a key method of minimizing the extent of yield losses caused by the globally important wheat leaf rust (LR) and stripe rust (YR) diseases. In this study, a population of 186 F 8 recombinant inbred lines (RILs) derived from a cross between a synthetic wheat derivative (PI610750) and an adapted common wheat line (cv. "UC1110") were phenotyped for LR and YR response at both seedling and adult plant stages over multiple seasons. Using a genetic linkage map consisting of single sequence repeats and diversity arrays technology markers, in combination with inclusive composite interval mapping analysis, we detected a new LR adult plant resistance (APR) locus, QLr.cim-2DS , contributed by UC1110. One co-located resistance locus to both rusts, QLr.cim-3DC/QYr.cim-3DC , and the known seedling resistance gene Lr26 were also mapped. QLr.cim-2DS and QLr.cim-3DC showed a marginally significant interaction for LR resistance in the adult plant stage. In addition, two previously reported YR APR loci, QYr.ucw-3BS and Yr48 , were found to exhibit stable performances in rust environments in both Mexico and the United States and showed a highly significant interaction in the field. Yr48 was also observed to confer intermediate seedling resistance against Mexican YR races, thus suggesting it should be re-classified as an all-stage resistance gene. We also identified 5 and 2 RILs that possessed all detected YR and LR resistance loci, respectively. With the closely linked molecular markers reported here, these RILs could be used as donors for multiple resistance loci to both rusts in wheat breeding programs.

Preparation of UC0.07-0.10N0.90-0.93 spheres for TRISO coated fuel particles

NASA Astrophysics Data System (ADS)

Hunt, R. D.; Silva, C. M.; Lindemer, T. B.; Johnson, J. A.; Collins, J. L.

2014-05-01

The US Department of Energy is considering a new nuclear fuel that would be less susceptible to ruptures during a loss-of-coolant accident. The fuel would consist of tristructural isotropic coated particles with dense uranium nitride (UN) kernels with diameters of 650 or 800 μm. The objectives of this effort are to make uranium oxide microspheres with adequately dispersed carbon nanoparticles and to convert these microspheres into UN spheres, which could be then sintered into kernels. Recent improvements to the internal gelation process were successfully applied to the production of uranium gel spheres with different concentrations of carbon black. After the spheres were washed and dried, a simple two-step heat profile was used to produce porous microspheres with a chemical composition of UC0.07-0.10N0.90-0.93. The first step involved heating the microspheres to 2023 K in a vacuum, and in the second step, the microspheres were held at 1873 K for 6 h in flowing nitrogen.

The Cygnus OB2 Star Forming Complex

NASA Astrophysics Data System (ADS)

Rybarczyk, Daniel R.; Bania, Thomas

2018-01-01

Almost all astrophysical systems—from planets to stars to supernovae to entire galaxies—are impacted by the process of star formation. The brightest, most massive stars (OB stars) form in hot young clusters called OB associations. Cygnus OB2 is an OB association containing over 160 OB stars, making it one of the largest in the Milky Way Galaxy. At a distance of less than 1.5 kpc, its proximity to the Sun makes it optimal for assessing the process of Galactic star formation and its implications for stellar evolution, Galactic structure, and Galactic chemical evolution. Using existing data sets, we derive comprehensive maps of the distribution of thermal continuum, atomic, and molecular emission from the interstellar gas in Cyg OB2. The thermal continuum emission stems from the plasma ionized by OB stars. The atomic gas is probed by emission from atomic hydrogen, HI, at 21 cm wavelength. The molecular gas is traced by emission from the CO molecule which is a proxy for molecular hydrogen, H2. We combine these atomic and molecular data to derive a map of the total proton column density distribution in Cyg OB2. We also analyze the velocity fields of the OB stars, the atomic and molecular hydrogen gas, and the HII regions' radio recombination emission. As expected, we find HII regions to be spatially coincident with zones of higher cloud density. Surrounding the greatest concentration of OB stars is a cavity in the radio continuum and CO emission. This results from shock waves produced by the combined action of the high HII region pressure and winds from the OB stars. Such a distribution implies that Cyg OB2 is old enough to have evolved to this state.

The GBT Diffuse Ionized Gas Survey (GDIGS)

NASA Astrophysics Data System (ADS)

Luisi, Matteo; Anderson, Loren Dean; Liu, Bin; Bania, Thomas; Balser, Dana; Wenger, Trey; Haffner, Lawrence Matthew

2018-01-01

Diffuse ionized gas in the Galactic mid-plane known as the "Warm Ionized Medium" (WIM) makes up ~20% of the gas mass of the Milky Way and >90% of its ionized gas. It is the last major component of the interstellar medium (ISM) that has not yet been studied at high spatial and spectral resolution, and therefore many of its fundamental properties remain unclear. The Green Bank Telescope (GBT) Diffuse Ionized Gas Survey (GDIGS) is a new large survey of the Milky Way disk at C-band (4-8 GHz). The main goals of GDIGS are to investigate the properties of the WIM and to determine the connection between the WIM and high-mass star formation over the Galactic longitude and latitude range of 32 deg > l > -5 deg, |b| < 0.5 deg. We use the new VEGAS spectrometer to simultaneously observe 22 Hn-alpha radio recombination lines, 25 Hn-beta lines, 8 Hn-gamma lines, and 9 molecular lines (namely CH3OH and H2CO), and also continuum at ~60 frequencies. We average the Hn-alpha lines to produce Nyquist-sampled maps on a spatial grid of 1 arcmin, a velocity resolution of 0.5 km/s and rms sensitivities of ~3 mJy per beam. GDIGS observations are currently underway and are expected to be completed by late 2018. These data will allow us to: 1) Study for the first time the inner-Galaxy WIM unaffected by confusion from discrete HII regions, 2) determine the distribution of the inner Galaxy WIM, 3) investigate the ionization state of the WIM, 4) explore the connection between the WIM and HII regions, and 5) analyze the effect of leaked photons from HII regions on ISM dust temperatures.

Chemical abundances of the PRGs UGC 7576 and UGC 9796. I. Testing the formation scenario

NASA Astrophysics Data System (ADS)

Spavone, M.; Iodice, E.; Arnaboldi, M.; Longo, G.; Gerhard, O.

2011-07-01

Context. The study of both the chemical abundances of HII regions in polar ring galaxies and their implications for the evolutionary scenario of these systems has been a step forward both in tracing the formation history of the galaxy and giving hints toward the mechanisms at work during the building of a disk by cold accretion process. It is now important to establish whether such results are typical of the class of polar disk galaxies as a whole. Aims: The present work aims at checking the cold accretion of gas through a "cosmic filament" as a possible scenario for the formation of the polar structures in UGC 7576 and UGC 9796. If these form by cold accretion, we expect the HII regions abundances and metallicities to be lower than those of same-luminosity spiral disks, with values of Z ~ 1/10 Z⊙, as predicted by cosmological simulations. Methods: We used deep long-slit spectra, obtained with DOLORES@TNG in the optical wavelengths, of the brightest HII regions associated with the polar structures to derive their chemical abundances and star formation rate. We used the empirical methods, based on the intensities of easily observable lines, to derive the oxygen abundance 12 + log (O/H) of both galaxies. Such values are compared with those typical of different morphological galaxy types of comparable luminosity. Results: The average metallicity values for UGC 7576 and UGC 9796 are Z = 0.4 Z⊙ and Z = 0.1 Z⊙, respectively. Both values are lower than those measured for ordinary spirals of similar luminosity, and UGC 7576 presents no metallicity gradient along the polar structure. These data, together with other observed features available for the two PRGs in previous works, are compared with the predictions of simulations of tidal accretion, cold accretion, and merging to disentangle these scenarios.

Evolution of the High Velocity X-Ray Emission in SN 1987A

NASA Astrophysics Data System (ADS)

Dewey, Daniel; Haberl, F.; Dwarkadas, V. V.; Burrows, D. N.; Park, S.

2011-01-01

Chandra HETG observations of SN 1987A in late 1999 showed very broad lines with observed FWHM of order 7000 km/s (Michael et al. 2002). At this time (SN day 4600) the blastwave was already interacting with the HII region around the progenitor and optical spots had recently appeared. High-resolution spectra taken from May 2003 ( day 5900) to the present by XMM-Newton and Chandra have been well fit by models with FWHM less than 2000 km/s (Zhekov et al. 2005; Dewey et al. 2008; Sturm et al 2010). The emission is increasingly dominated by these narrower components as the blastwave encounters more of the dense equatorial ring. However emission from the HII region out of the ring plane is still expected at late times and would contribute a high-velocity component to the spectra. We analyze 6 epochs of SN 1987A grating data and include an additional very broad component in the spectral model. We find that deep HETG 2007 data are better fit when one quarter of the flux comes from a component with FWHM 8500 km/s, and that RGS 2003 data show an improved fit with a very-broad fraction that is between the 1999 and 2007 values. Later data continue a progression to lower, but still significant, very-broad fractions. The measurements are discussed in terms of the density and extent of the out-of-plane HII region, hydrodynamical simulations, and 3D models of SN 1987A's emission. Support for this work was provided by NASA/USA through contract NAS8-03060 to the Smithsonian Astrophysical Observatory (SAO) and further SAO sub-contracts TM9-0004X to VVD (U Chicago) and SV3-73016 to MIT for support of the CXC.

Ngc7538 Irs1 - A Highly Collimated Ionized Wind Source Powered By Accretion

NASA Astrophysics Data System (ADS)

Sandell, Goran H. L.; Wright, M.; Goss, W.; Corder, S.

2009-01-01

Recent images show that NGC7538 IRS1 is not a conventional Ultracompact or Hypercompact HII region, but is completely wind-excited (other broad recombination line hypercompact HII regions may be similar to IRS1). NGC 7538 IRS1 is a well studied young high-mass star (L 2 10^5 L_Sun).VLA images at 6 and 2 cm (Cambell 1984; ApJ, 282, L27) showed a compact bipolar core (lobe separation 0.2") with more extended faint lobes. Recombination line observations (Gaume et al. 1995, ApJ, 438, 776) show extremely wide line profiles indicating substantial mass motion of the ionized gas. We re-analyzed high angular resolution VLA archive data from 6 cm to 7 mm, and measured the flux from the compact core and the extended (1.5 - 2") bipolar lobes. We find that the compact core has a spectral index, alpha 0.6, which could be explained by an optically thick hypercompact core with a density gradient. However, the size of the core shrinks with increasing frequency; from 0.24" at 6 cm to 0.1" at 7 mm, consistent with that expected for a collimated jet (Reynolds 1986, ApJ, 304, 713). If we do a crude size correction so that we compare emission from the optically thick inner part of the jet for a set of 2 cm and 7 mm observations we get alpha 1.6, i.e. close to the optically thick value. BIMA and CARMA continuum observations at 3 mm show some dust excess, while. HCO+ J=1-0 observations combined with FCRAO single dish data show a clear inverse P Cygni profile towards IRS1. These observations confirm that IRS1 is heavily accreting with an accretion rate 2 10^-4 M_Sun/year, sufficient to quench the formation of an HII region.

Enhanced cell survival and paracrine effects of mesenchymal stem cells overexpressing hepatocyte growth factor promote cardioprotection in myocardial infarction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Liyan; Liu, Xiaolin; Zhang, Yuelin

Poor cell survival post transplantation compromises the therapeutic benefits of mesenchymal stem cells (MSCs) in myocardial infarction (MI). Hepatocyte growth factor (HGF) is an important cytokine for angiogenesis, anti-inflammation and anti-apoptosis. This study aimed to evaluate the cardioprotective effects of MSCs overexpressing HGF in a mouse model of MI. The apoptosis of umbilical cord-derived MSCs (UC-MSCs) and HGF-UC-MSCs under normoxic and hypoxic conditions was detected. The conditioned medium (CdM) of UC-MSCs and HGF-UC-MSCs under a hypoxic condition was harvested and its protective effect on neonatal cardiomyocytes (NCMs) exposed to a hypoxic challenge was examined. UC-MSCs and HGF-UC-MSCs were transplanted intomore » the peri-infarct region in mice following MI and heart function assessed 4 weeks post transplantation. The apoptosis of HGF-UC-MSCs under hypoxic conditions was markedly decreased compared with that of UC-MSCs. NCMs treated with HGF-UC-MSC hypoxic CdM (HGF-UC-MSCs-hy-CdM) exhibited less cell apoptosis in response to hypoxic challenge than those treated with UC-MSC hypoxic CdM (UC-MSCs-hy-CdM). HGF-UC-MSCs-hy-CdM released the inhibited p-Akt and lowered the enhanced ratio of Bax/Bcl-2 induced by hypoxia in the NCMs. HGF-UC-MSCs-hy-CdM expressed higher levels of HGF, EGF, bFGF and VEGF than UC-MSCs-hy-CdM. Transplantation of HGF-UC-MSCs or UC-MSCs greatly improved heart function in the mouse model of MI. Compared with UC-MSCs, transplantation of HGF-UC-MSCs was associated with less cardiomyocyte apoptosis, enhanced angiogenesis and increased proliferation of cardiomyocytes. This study may provide a novel therapeutic strategy for MSC-based therapy in cardiovascular disease.« less

Nationwide analysis on the impact of socioeconomic land use factors and incidence of urothelial carcinoma.

PubMed

Brandt, Maximilian P; Gust, Kilian M; Mani, Jens; Vallo, Stefan; Höfner, Thomas; Borgmann, Hendrik; Tsaur, Igor; Thomas, Christian; Haferkamp, Axel; Herrmann, Eva; Bartsch, Georg

2018-02-01

Incidence rates for urothelial carcinoma (UC) have been reported to differ between countries within the European Union (EU). Besides occupational exposure to chemicals, other substances such as tobacco and nitrite in groundwater have been identified as risk factors for UC. We investigated if regional differences in UC incidence rates are associated with agricultural, industrial and residential land use. Newly diagnosed cases of UC between 2003 and 2010 were included. Information within 364 administrative districts of Germany from 2004 for land use factors were obtained and calculated as a proportion of the total area of the respective administrative district and as a smoothed proportion. Furthermore, information on smoking habits was included in our analysis. Kulldorff spatial clustering was used to detect different clusters. A negative binomial model was used to test the spatial association between UC incidence as a ratio of observed versus expected incidence rates, land use and smoking habits. We identified 437,847,834 person years with 171,086 cases of UC. Cluster analysis revealed areas with higher incidence of UC than others (p=0.0002). Multivariate analysis including significant pairwise interactions showed that the environmental factors were independently associated with UC (p<0.001). The RR was 1.066 (95% CI 1.052-1.080), 1.066 (95% CI 1.042-1.089) and 1.067 (95% CI 1.045-1.093) for agricultural, industrial and residential areas, respectively, and 0.996 (95% CI 0.869-0.999) for the proportion of never smokers. This study displays regional differences in incidence of UC in Germany. Additionally, results suggest that socioeconomic factors based on agricultural, industrial and residential land use may be associated with UC incidence rates. Copyright © 2017 Elsevier Ltd. All rights reserved.

Evaluation of the Program in Medical Education for the Urban Underserved (PRIME-US) at the UC Berkeley-UCSF Joint Medical Program (JMP): The First 4 Years.

PubMed

Sokal-Gutierrez, Karen; Ivey, Susan L; Garcia, Roxanna M; Azzam, Amin

2015-01-01

Medical educators, clinicians, and health policy experts widely acknowledge the need to increase the diversity of our healthcare workforce and build our capacity to care for medically underserved populations and reduce health disparities. The Program in Medical Education for the Urban Underserved (PRIME-US) is part of a family of programs across the University of California (UC) medical schools aiming to recruit and train physicians to care for underserved populations, expand the healthcare workforce to serve diverse populations, and promote health equity. PRIME-US selects medical students from diverse backgrounds who are committed to caring for underserved populations and provides a 5-year curriculum including a summer orientation, a longitudinal seminar series with community engagement and leadership-development activities, preclerkship clinical immersion in an underserved setting, a master's degree, and a capstone rotation in the final year of medical school. This is a mixed-methods evaluation of the first 4 years of the PRIME-US at the UC Berkeley-UC San Francisco Joint Medical Program (JMP). From 2006 to 2010, focus groups were conducted each year with classes of JMP PRIME-US students, for a total of 11 focus groups; major themes were identified using content analysis. In addition, 4 yearly anonymous, online surveys of all JMP students, faculty and staff were conducted and analyzed. Most PRIME-US students came from socioeconomically disadvantaged backgrounds and ethnic backgrounds underrepresented in medicine, and all were committed to caring for underserved populations. The PRIME-US students experienced many program benefits including peer support, professional role models and mentorship, and curricular enrichment activities that developed their knowledge, skills, and sustained commitment to care for underserved populations. Non-PRIME students, faculty, and staff also benefited from participating in PRIME-sponsored seminars and community-based activities

Surprises in Studies of Superdeformation in the Mass A ~80 Region.

NASA Astrophysics Data System (ADS)

Lafosse, Dennis R.

1996-11-01

The study of superdeformation (SD) in the light nuclei around A ~80 only recently began with the advent of the third generation of γ-ray detector arrays. The uc(gammasphere) array in conjunction with the Washington University uc(microball) have offered unprecedented sensitivity in this mass region, which has been applied effectively to the study of these nuclei. Whereas there were no SD bands known in this light mass region only two years ago, over 20 bands in 9 nuclei have recently been discovered. Interesting systematic properties are beginning to emerge. For example, the measured deformations of the yrast SD bands in _38Sr nuclei show a large dependence on neutron number; the deformation of the yrast band in ^80Sr was determined to be surprisingly small, and comparable to that of the yrast normal-deformed states! Individual nuclei have also revealed surprising features. For example, an SD band in ^81Sr was found to decay out to another (SD?) state, but then to decay back into the SD band. A very interesting result was found in ^87Nb. Two SD bands in ^87Nb have been found to mutually interact with each other, and resulting cross transitions between the two bands have been observed. This interaction has been traced to a crossing of two neutron orbitals. Finally, future surprises may be in store. SD bands in this mass region are observed to extremely high rotational frequencies, often approaching hbarω=1.5 MeV. The extreme Coriolis force then brings the N=6 i_13/2 orbital down to the Fermi surface. Thus, SD bands having deformations approaching β_2=0.8 may be observed as a result of the high deformation driving property of these ``superintruder'' orbitals. The first hint of such states may have already been discovered in ^87Nb. One of the SD bands in this nucleus reveals a crossing which is likely due to the occupation of the i_13/2 orbital at the highest frequencies. The work to be presented is the result of an ongoing collaboration between Washington

Expanding the Graduate Education Experience at Scripps Institution of Oceanography, UC San Diego

NASA Astrophysics Data System (ADS)

Peach, C. L.; Kilb, D. L.; Zmarzly, D.; Abeyta, E.

2016-02-01

Emerging career pathways for graduate students in earth, ocean and climate sciences increasingly require skills in teaching and communication. This is true of academic careers, in which demonstrated teaching skills make applicants for faculty positions far more competitive, and traditionally less conventional careers outside of academia that require cross-disciplinary collaboration and/or communication to audiences not directly involved in science research (e.g. policy makers, educators, the public). Yet most graduate education programs provide little to no opportunity or incentive for young investigators to develop and hone these skills, and graduate students are often discouraged from deviating from the traditional "research apprenticeship" model during their graduate education. At Scripps, the Birch Aquarium at Scripps, and UC San Diego Extension, we are developing new ways to integrate teaching, communication, and outreach into our graduate education program, thus broadening the scope of graduate training and better serving the needs and evolving career aspirations of our graduate students. This effort is an integral part of our overall outreach strategy a Scripps in which we seek to combine high quality STEM outreach and teaching with opportunities for Scripps graduate students to put their teaching and communications training into practice. The overall effort is a "win-win" both for our students and for the highly diverse K-16 community in San Diego County. In this talk we will summarize the programmatic efforts currently underway at Scripps, our strategic collaboration with UCSD Extension, which is expanding the capacity and reach of our integrated program, and our plans for sustaining these efforts for the long term.

Report on the Program “Fluid-mediated particle transport in geophysical flows” at the Kavli Institute for Theoretical Physics, UC Santa Barbara, September 23 to December 12, 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jenkins, James T.; Meiburg, Eckart; Valance, Alexandre

2015-09-15

The Kavli Institute of Theoretical Physics (KITP) program held at UC Santa Barbara in the fall of 2013 addressed the dynamics of dispersed particulate flows in the environment. By focusing on the prototypes of aeolian transport and turbidity currents, it aimed to establish the current state of our understanding of such two-phase flows, to identify key open questions, and to develop collaborative research strategies for addressing these questions. Here, we provide a brief summary of the program outcome.

Enhanced performance of dye-sensitized solar cells based on TiO{sub 2} with NIR-absorption and visible upconversion luminescence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, Li; Yulin, Yang, E-mail: ylyang@hit.edu.cn; Mi, Zhou

2013-02-15

TiO{sub 2} with NIR-absorption and visible upconversion luminescence (UC-TiO{sub 2}) is prepared by a sol-gel method and calcined at 700 Degree-Sign C for 6 h. The material broadens the response region of dye sensitized solar cells (DSSCs) from an ultraviolet-visible region to the whole region of the solar spectrum. It shifts NIR sunlight to visible light which matches the strong absorbing region of the dye (N719). DSSCs based on UC-TiO{sub 2} achieved higher conversion efficiency than that on raw TiO{sub 2}. UC-TiO{sub 2} was mixed with commercial raw TiO{sub 2} as additive, and the short-circuit current density, open-circuit voltage andmore » conversion efficiency of the DSSC reached to the optimum values 13.38 mA/cm{sup 2}, 0.78 V and 6.63% (AM1.5 global), comparing with the blank values: 7.99 mA/cm{sup 2}, 0.75 V and 4.07%, respectively. Also the mechanisms of upconversion by multiphoton absorption and energy transfer processes are interpreted in this paper. - Graphical abstract: By introducing TiO{sub 2} with NIR-absorption and visible up-conversion luminescence into DSSC, a signal reflection was explored from ultra-violet region to visible region, and to near-IR region. Highlights: Black-Right-Pointing-Pointer TiO{sub 2} with NIR-absorption and visible up-conversion luminescence (UC-TiO{sub 2}) was prepared by a sol-gel method. Black-Right-Pointing-Pointer A systematic characterization and analysis was carried out to discuss the mechanism. Black-Right-Pointing-Pointer A significantly enhanced performance of DSSC was explored by using UC-TiO{sub 2} as an additive.« less

Cloning of the Pseudomonas aeruginosa outer membrane porin protein P gene: evidence for a linked region of DNA homology.

PubMed Central

Siehnel, R J; Worobec, E A; Hancock, R E

1988-01-01

The gene encoding the outer membrane phosphate-selective porin protein P from Pseudomonas aeruginosa was cloned into Escherichia coli. The protein product was expressed and transported to the outer membrane of an E. coli phoE mutant and assembled into functional trimers. Expression of a product of the correct molecular weight was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot (immunoblot) analysis, using polyclonal antibodies to protein P monomer and trimer forms. Protein P trimers were partially purified from the E. coli clone and shown to form channels with the same conductance as those formed by protein P from P. aeruginosa. The location and orientation of the protein P-encoding (oprP) gene on the cloned DNA was identified by three methods: (i) mapping the insertion point of transposon Tn501 in a previously isolated P. aeruginosa protein P-deficient mutant; (ii) hybridization of restriction fragments from the cloned DNA to an oligonucleotide pool synthesized on the basis of the amino-terminal protein sequence of protein P; and (iii) fusion of a PstI fragment of the cloned DNA to the amino terminus of the beta-galactosidase gene of pUC8, producing a fusion protein that contained protein P-antigenic epitopes. Structural analysis of the cloned DNA and P. aeruginosa chromosomal DNA revealed the presence of two adjacent PstI fragments which cross-hybridized, suggesting a possible gene duplication. The P-related (PR) region hybridized to the oligonucleotide pool described above. When the PstI fragment which contained the PR region was fused to the beta-galactosidase gene of pUC8, a fusion protein was produced which reacted with a protein P-specific antiserum. However, the restriction endonuclease patterns of the PR region and the oprP gene differed significantly beyond the amino-terminal one-third of the two genes. Images PMID:2834340

Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study.

PubMed

Watanabe, Zen; Iwama, Noriyuki; Nishigori, Hidekazu; Nishigori, Toshie; Mizuno, Satoshi; Sakurai, Kasumi; Ishikuro, Mami; Obara, Taku; Tatsuta, Nozomi; Nishijima, Ichiko; Fujiwara, Ikuma; Nakai, Kunihiko; Arima, Takahiro; Takeda, Takashi; Sugawara, Junichi; Kuriyama, Shinichi; Metoki, Hirohito; Yaegashi, Nobuo

2016-01-15

To examine psychological distress among pregnant women in Miyagi prefecture which was directly affected by the Great East Japan Earthquake and tsunami and compare other areas of Japan that were less damaged. This study was conducted in conjunction with the Japan Environment and Children's Study (JECS). We examined 10,129 Japanese women using the primary fixed data of the JECS. The Kessler 6-item psychological distress scale (K6) was administered to 7473 eligible women including 998 in Miyagi unit center ('Miyagi UC') and 6475 in the other unit centers ('13UCs'). We compared the prevalence and the risk of distress (K6 ≥ 13) during pregnancy in 'Miyagi UC' and '13UCs'. More women in 'Miyagi UC' (4.9%) suffered psychological distress, compared with '13UCs' (3.1%) (p<0.001). A significantly higher prevalence of women in 'Miyagi UC' (55.5%) had experienced negative life events, whereas '13UCs' showed 42.7% (p<0.0001). In multivariable logistic analyses adjusted for baseline characteristics, there was a significant regional difference of psychological distress (adjusted odds ratio; aOR in Miyagi UC=1.488; 95%CI, 1.059-2.090). After further adjusting for negative life events, the association was diminished (aOR=1.338; 95%CI, 0.949-1.884). The JECS had no data before the earthquake and the extent of damage was not investigated. Possible regional representativeness is also a limitation. After the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress (K6 ≥ 13) were high in Miyagi prefecture. Especially in the coastal area directly affected by tsunami, it is high with or without negative life events experienced. Copyright © 2015 Elsevier B.V. All rights reserved.

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

PubMed Central

Shapiro, S. G.; Raghunath, S.; Williams, C.; Motsinger-Reif, A. A.; Cullen, J. M.; Liu, T.; Albertson, D.; Ruvolo, M.; Lucas, A. Bergstrom; Jin, J.; Knapp, D. W.; Schiffman, J. D.

2015-01-01

Urothelial carcinoma (UC), also referred to as transitional cell carcinoma (TCC), is the most common bladder malignancy in both human and canine populations. In human UC, numerous studies have demonstrated the prevalence of chromosomal imbalances. Although the histopathology of the disease is similar in both species, studies evaluating the genomic profile of canine UC are lacking, limiting the discovery of key comparative molecular markers associated with driving UC pathogenesis. In the present study, we evaluated 31 primary canine UC biopsies by oligonucleotide array comparative genomic hybridization (oaCGH). Results highlighted the presence of three highly recurrent numerical aberrations: gain of dog chromosome (CFA) 13 and 36 and loss of CFA 19. Regional gains of CFA 13 and 36 were present in 97% and 84% of cases, respectively, and losses on CFA 19 were present in 77% of cases. Fluorescence in situ hybridization (FISH), using targeted bacterial artificial chromosome (BAC) clones and custom Agilent SureFISH probes, was performed to detect and quantify these regions in paraffin-embedded biopsy sections and urine-derived urothelial cells. The data indicate that these three aberrations are potentially diagnostic of UC. Comparison of our canine oaCGH data with that of 285 human cases identified a series of shared copy number aberrations. Using an informatics approach to interrogate the frequency of copy number aberrations across both species, we identified those that had the highest joint probability of association with UC. The most significant joint region contained the gene PABPC1, which should be considered further for its role in UC progression. In addition, cross-species filtering of genome-wide copy number data highlighted several genes as high-profile candidates for further analysis, including CDKN2A, S100A8/9, and LRP1B. We propose that these common aberrations are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to

Canine urothelial carcinoma: genomically aberrant and comparatively relevant.

PubMed

Shapiro, S G; Raghunath, S; Williams, C; Motsinger-Reif, A A; Cullen, J M; Liu, T; Albertson, D; Ruvolo, M; Bergstrom Lucas, A; Jin, J; Knapp, D W; Schiffman, J D; Breen, M

2015-06-01

Urothelial carcinoma (UC), also referred to as transitional cell carcinoma (TCC), is the most common bladder malignancy in both human and canine populations. In human UC, numerous studies have demonstrated the prevalence of chromosomal imbalances. Although the histopathology of the disease is similar in both species, studies evaluating the genomic profile of canine UC are lacking, limiting the discovery of key comparative molecular markers associated with driving UC pathogenesis. In the present study, we evaluated 31 primary canine UC biopsies by oligonucleotide array comparative genomic hybridization (oaCGH). Results highlighted the presence of three highly recurrent numerical aberrations: gain of dog chromosome (CFA) 13 and 36 and loss of CFA 19. Regional gains of CFA 13 and 36 were present in 97 % and 84 % of cases, respectively, and losses on CFA 19 were present in 77 % of cases. Fluorescence in situ hybridization (FISH), using targeted bacterial artificial chromosome (BAC) clones and custom Agilent SureFISH probes, was performed to detect and quantify these regions in paraffin-embedded biopsy sections and urine-derived urothelial cells. The data indicate that these three aberrations are potentially diagnostic of UC. Comparison of our canine oaCGH data with that of 285 human cases identified a series of shared copy number aberrations. Using an informatics approach to interrogate the frequency of copy number aberrations across both species, we identified those that had the highest joint probability of association with UC. The most significant joint region contained the gene PABPC1, which should be considered further for its role in UC progression. In addition, cross-species filtering of genome-wide copy number data highlighted several genes as high-profile candidates for further analysis, including CDKN2A, S100A8/9, and LRP1B. We propose that these common aberrations are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes

ULTRAVIOLET SPECTROSCOPY OF RAPIDLY ROTATING SOLAR-MASS STARS: EMISSION-LINE REDSHIFTS AS A TEST OF THE SOLAR-STELLAR CONNECTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linsky, Jeffrey L.; Bushinsky, Rachel; Ayres, Tom

2012-07-20

We compare high-resolution ultraviolet spectra of the Sun and thirteen solar-mass main-sequence stars with different rotational periods that serve as proxies for their different ages and magnetic field structures. In this, the second paper in the series, we study the dependence of ultraviolet emission-line centroid velocities on stellar rotation period, as rotation rates decrease from that of the Pleiades star HII314 (P{sub rot} = 1.47 days) to {alpha} Cen A (P{sub rot} = 28 days). Our stellar sample of F9 V to G5 V stars consists of six stars observed with the Cosmic Origins Spectrograph on the Hubble Space Telescopemore » (HST) and eight stars observed with the Space Telescope Imaging Spectrograph on HST. We find a systematic trend of increasing redshift with more rapid rotation (decreasing rotation period) that is similar to the increase in line redshift between quiet and plage regions on the Sun. The fastest-rotating solar-mass star in our study, HII314, shows significantly enhanced redshifts at all temperatures above log T = 4.6, including the corona, which is very different from the redshift pattern observed in the more slowly rotating stars. This difference in the redshift pattern suggests that a qualitative change in the magnetic-heating process occurs near P{sub rot} = 2 days. We propose that HII314 is an example of a solar-mass star with a magnetic heating rate too large for the physical processes responsible for the redshift pattern to operate in the same way as for the more slowly rotating stars. HII314 may therefore lie above the high activity end of the set of solar-like phenomena that is often called the 'solar-stellar connection'.« less

VizieR Online Data Catalog: Giant HII regions BOND abundances (Vale Asari+, 2016)

NASA Astrophysics Data System (ADS)

Vale Asari, N.; Stasinska, G.; Morisset, C.; Cid Fernandes, R.

2017-10-01

BOND determines nitrogen and oxygen gas-phase abundances by using strong and semistrong lines and comparing them to a grid of photoionization models in a Bayesian framework. The code is written in python and its source is publicly available at http://bond.ufsc.br. The grid of models presented here is included in the 3MdB data base (Morisset, Delgado-Inglada & Flores-Fajardo 2015RMxAA..51..103M, see https://sites.google.com/site/mexicanmillionmodels/) under the reference 'BOND'. The Bayesian posterior probability calculated by bond stands on two pillars: our grid of models and our choice of observational constraints (from which we calculate our likelihoods). We discuss each of these in turn. (2 data files).

Searching for Compact Radio Sources Associated with UCH ii Regions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Masqué, Josep M.; Trinidad, Miguel A.; Rodríguez-Rico, Carlos A.

Ultra-compact (UC)H ii regions represent a very early stage of massive star formation. The structure and evolution of these regions are not yet fully understood. Interferometric observations showed in recent years that compact sources of uncertain nature are associated with some UCH ii regions. To examine this, we carried out VLA 1.3 cm observations in the A configuration of selected UCH ii regions in order to report additional cases of compact sources embedded in UCH ii regions. With these observations, we find 13 compact sources that are associated with 9 UCH ii regions. Although we cannot establish an unambiguous naturemore » for the newly detected sources, we assess some of their observational properties. According to the results, we can distinguish between two types of compact sources. One type corresponds to sources that are probably deeply embedded in the dense ionized gas of the UCH ii region. These sources are photoevaporated by the exciting star of the region and will last for 10{sup 4}–10{sup 5} years. They may play a crucial role in the evolution of the UCH ii region as the photoevaporated material could replenish the expanding plasma and might provide a solution to the so-called lifetime problem of these regions. The second type of compact sources is not associated with the densest ionized gas of the region. A few of these sources appear resolved and may be photoevaporating objects such as those of the first type, but with significantly lower mass depletion rates. The remaining sources of this second type appear unresolved, and their properties are varied. We speculate on the similarity between the sources of the second type and those of the Orion population of radio sources.« less

Radio Observations of Sgr B2

NASA Astrophysics Data System (ADS)

Mao, Xin-Jie; Su, Jiang-Tao

2001-10-01

The 13CO (J=1-0) map of the molecular cloud Sgr B2 reveals that the mass center of the molecular cloud nucleus does not coincide with that of compact HII regions which are likely to be the outcome of a shock on the cloud. We find evidence of cloud contraction probably resulting from cloud-cloud collision at subsonic speed.

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

PubMed

Visschedijk, Marijn C; Alberts, Rudi; Mucha, Soren; Deelen, Patrick; de Jong, Dirk J; Pierik, Marieke; Spekhorst, Lieke M; Imhann, Floris; van der Meulen-de Jong, Andrea E; van der Woude, C Janneke; van Bodegraven, Adriaan A; Oldenburg, Bas; Löwenberg, Mark; Dijkstra, Gerard; Ellinghaus, David; Schreiber, Stefan; Wijmenga, Cisca; Rivas, Manuel A; Franke, Andre; van Diemen, Cleo C; Weersma, Rinse K

2016-01-01

Genome-wide association studies have revealed several common genetic risk variants for ulcerative colitis (UC). However, little is known about the contribution of rare, large effect genetic variants to UC susceptibility. In this study, we performed a deep targeted re-sequencing of 122 genes in Dutch UC patients in order to investigate the contribution of rare variants to the genetic susceptibility to UC. The selection of genes consists of 111 established human UC susceptibility genes and 11 genes that lead to spontaneous colitis when knocked-out in mice. In addition, we sequenced the promoter regions of 45 genes where known variants exert cis-eQTL-effects. Targeted pooled re-sequencing was performed on DNA of 790 Dutch UC cases. The Genome of the Netherlands project provided sequence data of 500 healthy controls. After quality control and prioritization based on allele frequency and pathogenicity probability, follow-up genotyping of 171 rare variants was performed on 1021 Dutch UC cases and 1166 Dutch controls. Single-variant association and gene-based analyses identified an association of rare variants in the MUC2 gene with UC. The associated variants in the Dutch population could not be replicated in a German replication cohort (1026 UC cases, 3532 controls). In conclusion, this study has identified a putative role for MUC2 on UC susceptibility in the Dutch population and suggests a population-specific contribution of rare variants to UC.

Collaboration in Action: Measuring and Improving Contracting Performance in the University of California Contracting Network

ERIC Educational Resources Information Center

Tran, Tam; Bowman-Carpio, LeeAnna; Buscher, Nate; Davidson, Pamela; Ford, Jennifer J.; Jenkins, Erick; Kalay, Hillary Noll; Nakazono, Terry; Orescan, Helene; Sak, Rachael; Shin, Irene

2017-01-01

In 2013, the University of California, Biomedical Research, Acceleration, Integration, and Development (UC BRAID) convened a regional network of contracting directors from the five University of California (UC) health campuses to: (i) increase collaboration, (ii) operationalize and measure common metrics as a basis for performance improvement…

The heavy ions in space experiment

NASA Technical Reports Server (NTRS)

Adams, J. H., Jr.; Beahm, L. P.; Stiller, B.

1985-01-01

The Heavy Ions in Space (HIIS) experiment was developed and is currently in orbit onboard the long duration facility (LDEF). The HIIS will record relativistic cosmic ray nuclei heavier than magnesium and stopping nuclei down to helium. The experiment uses plastic track detectors that have a charge resolution of 0.15 charge units at krypton and 0.10 charge units, or better, for nuclei lighter than cobalt. The HIIS has a collecting power of 2 square meter steradians and it has already collected more than a year's data.

Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis.

PubMed

Kevans, D; Tyler, A D; Holm, K; Jørgensen, K K; Vatn, M H; Karlsen, T H; Kaplan, G G; Eksteen, B; Gevers, D; Hov, J R; Silverberg, M S

2016-03-01

There is an unexplained association between ulcerative colitis [UC] and primary sclerosing cholangitis [PSC], with the intestinal microbiota implicated as an important factor. The study aim was to compare the structure of the intestinal microbiota of patients with UC with and without PSC. UC patients with PSC [PSC-UC] and without PSC [UC] were identified from biobanks at Oslo University Hospital, Foothills Hospital Calgary and Mount Sinai Hospital Toronto. Microbial DNA was extracted from colonic tissue and sequencing performed of the V4 region of the 16S rRNA gene on Illumina MiSeq. Sequences were assigned to operational taxonomic units [OTUs] using Quantitative Insights Into Microbial Ecology [QIIME]. Microbial alpha diversity, beta diversity, and relative abundance were compared between PSC-UC and UC phenotypes. In all, 31 PSC-UC patients and 56 UC patients were included. Principal coordinate analysis [PCoA] demonstrated that city of sample collection was the strongest determinant of taxonomic profile. In the Oslo cohort, Chao 1 index was modestly decreased in PSC-UC compared with UC [p = 0.04] but did not differ significantly in the Calgary cohort. No clustering by PSC phenotype was observed using beta diversity measures. For multiple microbial genera there were nominally significant differences between UC and PSC-UC, but results were not robust to false-discovery rate correction. No strong PSC-specific microbial associations in UC patients consistent across different cohorts were identified. Recruitment centre had a strong effect on microbial composition. Future studies should include larger cohorts to increase power and the ability to control for confounding factors. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

High pressure behaviour of uranium dicarbide (UC{sub 2}): Ab-initio study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sahoo, B. D., E-mail: bdsahoo@barc.gov.in; Mukherjee, D.; Joshi, K. D.

2016-08-28

The structural stability of uranium dicarbide has been examined under hydrostatic compression employing evolutionary structure search algorithm implemented in the universal structure predictor: evolutionary Xtallography (USPEX) code in conjunction with ab-initio electronic band structure calculation method. The ab-initio total energy calculations involved for this purpose have been carried out within both generalized gradient approximations (GGA) and GGA + U approximations. Our calculations under GGA approximation predict the high pressure structural sequence of tetragonal → monoclinic → orthorhombic for this material with transition pressures of ∼8 GPa and 42 GPa, respectively. The same transition sequence is predicted by calculations within GGA + U also with transition pressuresmore » placed at ∼24 GPa and ∼50 GPa, respectively. Further, on the basis of comparison of zero pressure equilibrium volume and equation of state with available experimental data, we find that GGA + U approximation with U = 2.5 eV describes this material better than the simple GGA approximation. The theoretically predicted high pressure structural phase transitions are in disagreement with the only high experimental study by Dancausse et al. [J. Alloys. Compd. 191, 309 (1993)] on this compound which reports a tetragonal to hexagonal phase transition at a pressure of ∼17.6 GPa. Interestingly, during lowest enthalpy structure search using USPEX, we do not see any hexagonal phase to be closer to the predicted monoclinic phase even within 0.2 eV/f. unit. More experiments with varying carbon contents in UC{sub 2} sample are required to resolve this discrepancy. The existence of these high pressure phases predicted by static lattice calculations has been further substantiated by analyzing the elastic and lattice dynamic stability of these structures in the pressure regimes of their structural stability. Additionally, various thermo-physical quantities such

H-alpha LEGUS: Insights into the Field OB Star Population in Nearby Galaxies

NASA Astrophysics Data System (ADS)

Lee, Janice; Thilker, David; Kayitesi, Bridget; Chandar, Rupali; Halpha LEGUS Team

2018-01-01

The question of whether O-stars can form in isolation, without attendant clusters or associations of lower mass stars, is a topic of interest because the answer to the question can distinguish between models of star formation. To begin to investigate whether such isolated O-stars can be identified in nearby galaxies beyond the Local Group, we identify candidate field OB-stars in NGC 1313, NGC 4395 and NGC 7793, the three nearest spiral galaxies in the HST Legacy ExtraGalactic Ultraviolet Survey (LEGUS). Candidates are selected using a technique based on: (1) a reddening-free Q parameter, adapted for photometry in HST filters covering the NUV, U, & B bands; (2) isolation based on projected distance from the nearest young cluster and candidate OB star, and (3) the presence of an HII region, identified based on HST H-alpha narrowband imaging. Our catalogs enable a range of follow-up studies on massive stars, and in particular provide targets for future spectroscopic observation and analysis. We describe the candidate OB star sample, the spatial distribution of the stars, and their HII region properties, with special focus on the most isolated objects in the sample.

Ionization of the diffuse gas in galaxies: Hot low-mass evolved stars at work

NASA Astrophysics Data System (ADS)

Flores-Fajardo, N.; Morisset, C.; Stasinska, G.; Binette, L.

2011-10-01

The Diffuse Ionized Medium (DIG) is visible through its faint optical line emission outside classical HII regions (Reynolds 1971) and turns out to be a major component of the interstellar medium in galaxies. OB stars in galaxies likely represent the main source of ionizing photons for the DIG. However, an additional source is needed to explain the increase of [NII]/Hα, [SII]/Hα with galactic height.

Cosmochemistry

NASA Astrophysics Data System (ADS)

Esteban, C.; García López, R. J.; Herrero, A.; Sánchez, F.

2004-03-01

1. Primordial alchemy: from the Big Bang to the present Universe G. Steigman; 2. Stellar nucleosynthesis N. Langer; 3. Obervational aspects of stellar nucleosynthesis D. L. Lambert; 4. Abundance determinations in HII regions and planetary nebulae G. Stasinska; 5. Element abundances in nearby galaxies D. R. Garnett; 6. Chemical evolution of galaxies and intracluster medium F.Matteucci; 7. Element abundances through the cosmic ages M. Pettini.

Cosmochemistry

NASA Astrophysics Data System (ADS)

Esteban, C.; García López, R. J.; Herrero, A.; Sánchez, F.

2011-01-01

1. Primordial alchemy: from the Big Bang to the present Universe G. Steigman; 2. Stellar nucleosynthesis N. Langer; 3. Obervational aspects of stellar nucleosynthesis D. L. Lambert; 4. Abundance determinations in HII regions and planetary nebulae G. Stasinska; 5. Element abundances in nearby galaxies D. R. Garnett; 6. Chemical evolution of galaxies and intracluster medium F.Matteucci; 7. Element abundances through the cosmic ages M. Pettini.

Cartwheel Galaxy

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

A peculiar galaxy in the constellation of Sculptor that derives its name from its wheel-like appearance. The Cartwheel has a ring-shaped `rim', 150 000 light-years in diameter, that contains billions of recently formed stars and which is dominated by massive clusters of bright blue stars and HII regions. The nucleus, or `hub' of the galaxy contains a predominantly older population of stars and is...

VizieR Online Data Catalog: G346.056-0.021 and G346.077-0.056 radio images (Das+, 2018)

NASA Astrophysics Data System (ADS)

Das, S. R.; Tej, A.; Vig, S.; Liu, T.; Ghosh, S. K.; Chandra, C. H. I.

2018-02-01

To probe the ionized emission associated with the HII regions, radio continuum mapping was carried out at 610 and 1280MHz using the Giant Metrewave Radio Telescope (GMRT), Pune India. The continuum observations were carried out at 610 and 1280MHz with a bandwidth of 32MHz. For any clarification kindly contact : swagat.12(at)iist.ac.in / dasswagat77(at)gmail.com (2 data files).

An HL7/CDA Framework for the Design and Deployment of Telemedicine Services

DTIC Science & Technology

2001-10-25

schemes and prescription databases. Furthermore, interoperability with the Electronic Health Re- cord ( EHR ) facilitates automatic retrieval of relevant...local EHR system or the integrated electronic health record (I- EHR ) [9], which indexes all medical contacts of a patient in the regional net- work...suspected medical problem. Interoperability with middleware services of the HII and other data sources such as the local EHR sys- tem affects

Enhanced lipid accumulation and biodiesel production by oleaginous Chlorella protothecoides under a structured heterotrophic-iron (II) induction strategy.

PubMed

Li, Yuqin; Mu, Jinxiu; Chen, Di; Xu, Hua; Han, Fangxin

2015-05-01

A structured heterotrophic-iron (II) induction (HII) strategy was proposed to enhance lipid accumulation in oleaginous Chlorella protothecoides. C. protothecoides subjected to heterotrophic-iron (II) induction achieved a favorable lipid accumulation up to 62 % and a maximum lipid productivity of 820.17 mg/day, representing 2.78-fold and 3.64-fold increase respectively over heterotrophic cultivation alone. HII-induced cells produced significantly elevated levels of 16:0, 18:1(Δ9), and 18:2(Δ9,12) fatty acids (over 90 %). The lipid contents and plant lipid-like fatty acid compositions exhibit the potential of HII-induced C. protothecoides as biodiesel feedstock. Furthermore, 31 altered proteins in HII-induced algal cells were successfully identified. These differentially expressed proteins were assigned into nine molecular function categories, including carbohydrate metabolism, lipid biosynthesis, Calvin cycle, cellular respiration, photosynthesis, energy and transport, protein biosynthesis, regulate and defense, and unclassified. Analysis using the Kyoto encyclopedia of genes and genomes and gene ontology annotation showed that malic enzyme, acyltransferase, and ACP were key metabolic checkpoints found to modulate lipid accumulation in C. protothecoides. The results provided possible applications of HII cultivation strategy in other microalgal species and new possibilities in developing genetic and metabolic engineering microalgae for desirable lipid productivity.

GAME: GAlaxy Machine learning for Emission lines

NASA Astrophysics Data System (ADS)

Ucci, G.; Ferrara, A.; Pallottini, A.; Gallerani, S.

2018-06-01

We present an updated, optimized version of GAME (GAlaxy Machine learning for Emission lines), a code designed to infer key interstellar medium physical properties from emission line intensities of ultraviolet /optical/far-infrared galaxy spectra. The improvements concern (a) an enlarged spectral library including Pop III stars, (b) the inclusion of spectral noise in the training procedure, and (c) an accurate evaluation of uncertainties. We extensively validate the optimized code and compare its performance against empirical methods and other available emission line codes (PYQZ and HII-CHI-MISTRY) on a sample of 62 SDSS stacked galaxy spectra and 75 observed HII regions. Very good agreement is found for metallicity. However, ionization parameters derived by GAME tend to be higher. We show that this is due to the use of too limited libraries in the other codes. The main advantages of GAME are the simultaneous use of all the measured spectral lines and the extremely short computational times. We finally discuss the code potential and limitations.

Preliminary results from the heavy ions in space experiment

NASA Technical Reports Server (NTRS)

Adams, James H., Jr.; Beahm, Lorraine P.; Tylka, Allan J.

1992-01-01

The Heavy Ions In Space (HIIS) experiment has two primary objectives: (1) to measure the elemental composition of ultraheavy galactic cosmic rays, beginning in the tin-barium region of the periodic table; and (2) to study heavy ions which arrive at LDEF below the geomagnetic cutoff, either because they are not fully stripped of electrons or because their source is within the magnetosphere. Both of these objectives have practical as well as astrophysical consequences. In particular, the high atomic number of the ultraheavy galactic cosmic rays puts them among the most intensely ionizing particles in Nature. They are therefore capable of upsetting electronic components normally considered immune to such effects. The below cutoff heavy ions are intensely ionizing because of their low velocity. They can be a significant source of microelectronic anomalies in low inclination orbits, where Earth's magnetic field protects satellites from most particles from interplanetary space. The HIIS results will lead to significantly improved estimates of the intensely ionizing radiation environment.

HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis.

PubMed

Aizawa, H; Kinouchi, Y; Negoro, K; Nomura, E; Imai, G; Takahashi, S; Takagi, S; Kakuta, Y; Tosa, M; Mochida, A; Matsumura, Y; Endo, K; Shimosegawa, T

2009-06-01

Recently, a genome-wide association study for ulcerative colitis (UC) in the UK population was reported, and several susceptibility loci including the human leukocyte antigen (HLA) region were identified. The strongest association in the HLA region was found at a 400 kb haplotype block containing HLA-DRB1. In Japanese population, previous study suggested the association between UC and HLA-B*52; however, HLA typing was determined using serotyping with the small sample size. The purpose of this study was to perform an association study in HLA-B by genotyping. A total of 320 patients with UC and 322 healthy controls were recruited in this case-control study. All subjects were Japanese. Genotyping of HLA-B was performed by polymerase chain reaction using a sequence-specific primer. When the allele frequencies were compared, significant associations were found with B*52 [odds ratio (OR) = 3.65, P = 1.6 x 10(-17), P(c) = 3.7 x 10(-16)] and B*4002 (OR = 0.52, P = 0.00030, P(c) = 0.0068). The allele frequency of B*52 was significantly higher in patients diagnosed before 40 years of age than in those diagnosed after 40 years (OR = 1.79, P = 0.010, P(c) = 0.020). A combination association map of Japanese UC using our current and previous studies showed two equal peaks of association on HLA-DRB1 and HLA-B, indicating the possible existence of two casual variants in the HLA region inside and outside the 400 kb block found in UK. We conclude that HLA-B contributes to the susceptibility to Japanese UC, especially cases with younger age of onset. The strength of association for HLA-B was equal to that for HLA-DRB1 in Japanese UC, in contrast to the UK population.

Extended Galactic emission at l=312°: a comparison of mid-infrared and radio continuum (843 MHz) images

NASA Astrophysics Data System (ADS)

Cohen, Martin; Green, Anne J.

2001-08-01

We report on the comparison of images of a region of the Galactic plane (centred on l=312°) as seen by the Midcourse Space Experiment (MSX) at 8.3μm and by the Molonglo Observatory Synthesis Telescope (MOST) at 843MHz in the radio continuum. We note that the survey from each telescope is without peer and occupies a niche in panoramic coverage with high spatial resolution. Using independent classification of sources in the selected region, a detailed comparison of the two surveys was made. The aim of the project was to seek global characteristics for different types of source, with a view to establishing predictive criteria for identification and hence emission mechanisms. Several strong trends were found. There is a complete absence in this field of any detected MSX counterparts to non-thermal radio sources. Almost every Hii region in the radio image has its MSX counterpart, in the form of a polycyclic aromatic hydrocarbon halo in the neutral zone surrounding the ionized gas. Both surveys show large-scale `braided' filamentary structures, extending over 1°, which appear to be produced by thermal processes. These filaments may be structures in the warm ionized phase of the interstellar medium or extended haloes around Hii regions. The comparisons in this paper were made using both preliminary MSX 8.3-μm results with 46-arcsec resolution and final MSX images with the intrinsic 20-arcsec resolution of the instruments.

Probing the Extreme Environment of the Galactic Center with Observations from SOFIA/FORCAST

NASA Astrophysics Data System (ADS)

Lau, Ryan M.; Herter, Terry L.; Morris, Mark; Adams, Joseph D; Becklin, Eric E.

2014-06-01

In this thesis we present a study of the inner 40 pc of the Galactic center addressing the dense, dusty torus around Sgr A*, dust production around massive stars, and massive star formation. Observations of warm dust emission from the Galactic center were performed using the Faint Object Infrared Camera for the SOFIA Telescope (FORCAST). A dense, molecular torus referred to as the Circumnuclear Disk (CND) orbits Sgr A* with an inner radius of ~1.4 pc and extending to ~7 pc. The inner edge of the CND, which we refer to as the Circumnuclear Ring (CNR), exhibits features of a classic HII region and appears consistent with the prevailing paradigm in which the dust is heated by the Central cluster of hot, young stars. We do not detect any star formation occurring in the CNR; however, we reveal the presence of density “clumps” along the inner edge of the CNR. These clumps are not dense enough to be stable against tidal shear from Sgr A* and will be sheared out before completing a full orbit 10^5 yrs). Three Luminous Blue Variables (LBVs) are located in and near the Quintuplet Cluster 40 pc in projection from Sgr A*: qF362, the Pistol star, G0.120-0.048 (LBV3). FORCAST observation reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding LBV3. However, no detection of hot dust associated with qF362 is made. We argue that the Pistol star and LBV3 are identical “twins” that exhibit contrasting nebulae due to the external influence of their different environments. G-0.02-0.07, a complex consisting of three compact HII regions and one ultracompact HII region, is located at the edge of a molecular cloud 6 pc in projection to the east of Sgr A* and contains the most recent episode of star formation in the Galactic center. We probe the dust morphology, energetics, and composition of the regions to study the star forming conditions of a molecular

F-106 Scheduled Maintenance Study. User’s Manual,

DTIC Science & Technology

1972-09-01

TO HIST-TlTLE-1. 99030 MOVt HliT-NO-IF-OBS TO HIST-ERR-2. 9OUD0 HHITF HIST-HE^ FROM HIiT -TlTLE. 99050 MOVt III TO HISf-FLAO, 99U60...OCCURANCE INTO APPROPRIATE CHANNEL. 97bl0 MOVt 2L*0 TO HIST-INDEX-2. 97620 HIST-OCCUHANCf. 97b30 ADD 1 TO hIST-INDEX-2, 976*0 MOVt HIiT . VALUE t...WRITE HIST-REC FROM HIST-TITLE. C96970 MOVE IIS T3 HIST-FLAG. C98970 GO TO ENO-HIST. C98970 HIST-ERKOH-4. C98970 MOVt HIiT -ERR-i» TO HIST-TITLE-1

Involving Undergraduates in Aging Research at a University in Transition: An AREA Award

ERIC Educational Resources Information Center

Wood, Stacey

2006-01-01

Involving students in research with older adults at a university in transition has its unique challenges. The goal of this paper is to discuss some of the rewards and lessons learned in undertaking a research program involving undergraduates at the University of Colorado, Colorado Springs (UC-CS). UC-CS is a regional university in transition from…

Extension and flexion in the upper cervical spine in neck pain patients.

PubMed

Ernst, Markus J; Crawford, Rebecca J; Schelldorfer, Sarah; Rausch-Osthoff, Anne-Kathrin; Barbero, Marco; Kool, Jan; Bauer, Christoph M

2015-08-01

Neck pain is a common problem in the general population with high risk of ongoing complaints or relapses. Range of motion (ROM) assessment is scientifically established in the clinical process of diagnosis, prognosis and outcome evaluation in neck pain. Anatomically, the cervical spine (CS) has been considered in two regions, the upper and lower CS. Disorders like cervicogenic headache have been clinically associated with dysfunctions of the upper CS (UCS), yet ROM tests and measurements are typically conducted on the whole CS. A cross-sectional study assessing 19 subjects with non-specific neck pain was undertaken to examine UCS extension-flexion ROM in relation to self-reported disability and pain (via the Neck Disability Index (NDI)). Two measurement devices (goniometer and electromagnetic tracking) were employed and compared. Correlations between ROM and the NDI were stronger for the UCS compared to the CS, with the strongest correlation between UCS flexion and the NDI-headache (r = -0.62). Correlations between UCS and CS ROM were fair to moderate, with the strongest correlation between UCS flexion and CS extension ROM (r = -0.49). UCS flexion restriction is related to headache frequency and intensity. Consistency and agreement between both measurement systems and for all tests was high. The results demonstrate that separate UCS ROM assessments for extension and flexion are useful in patients with neck pain. Copyright © 2014 Elsevier Ltd. All rights reserved.

Formation des etoiles massives dans les galaxies spirales

NASA Astrophysics Data System (ADS)

Lelievre, Mario

Le but de cette thèse est de décrire la formation des étoiles massives dans les galaxies spirales appartenant à divers types morphologiques. L'imagerie Hα profonde combinée à une robuste méthode d'identification des régions HII ont permis de détecter et de mesurer les propriétés (position, taille, luminosité, taux de formation d'étoiles) de plusieurs régions HII situées dans le disque interne (R < R25) de dix galaxies mais aussi à leur périphérie (R ≥ R 25). De façon générale, la répartition des régions HII ne montre aucune évidence de structure morphologique à R < R25 (bras spiraux, anneau, barre) à moins de limiter l'analyse aux régions HII les plus grosses ou les plus lumineuses. La répartition des régions HII, de même que leur taille et leur luminosité, sont toutefois sujettes à de forts effets de sélection qui dépendent de la distance des galaxies et qu'il faut corriger en ramenant l'échantillon à une résolution spatiale commune. Les fonctions de luminosité montrent que les régions HII les plus brillantes ont tendance à se former dans la portion interne du disque. De plus, l'analyse des pentes révèle une forte corrélation linéaire par rapport au type morphologique. Aucun pic n'est observé dans les fonctions de luminosité à log L-37 qui révèlerait la transition entre les régions HII bornées par l'ionisation et par la densité. Une relation cubique est obtenue entre la taille et la luminosité des régions HII, cette relation variant toutefois de façon significative entre le disque interne et la périphérie d'une même galaxie. La densité et la dynamique du gaz et des étoiles pourraient influencer de façon significative la stabilité des nuages moléculaires face à l'effondrement gravitationnel. D'une part, l'étendue du disque de régions HII pour cinq galaxies de l'échantillon coïncide avec celle de l'hydrogène atomique. D'autre part, en analysant la stabilité des disques galactiques, on conclue

VizieR Online Data Catalog: Ultra-compact HII regions & methanol masers. I. (Hu+, 2016)

NASA Astrophysics Data System (ADS)

Hu, B.; Menten, K. M.; Wu, Y.; Bartkiewicz, A.; Rygl, K.; Reid, M. J.; Urquhart, J. S.; Zheng, X.

2017-03-01

372 unique targets were selected from the following methanol maser surveys: the Methanol Multi-Beam catalog (MMB; Caswell & Breen 2010MNRAS.407.2599C; Green+ 2010-2012, VIII/96), the Arecibo Methanol Maser Galactic Plane Survey (AMGPS; Pandian+ 2011ApJ...730...55P), the Torun catalog of 6.7GHz methanol masers (Szymczak+ 2012, J/AN/333/634), and other individual observations of known 6.7GHz methanol masers or MSFRs (Caswell+ 1995MNRAS.272...96C; Walsh+ 1997, J/MNRAS/291/261; 1998, J/MNRAS/301/640; Xu+ 2008A&A...485..729X; Caswell 2009, J/other/PASA/26.454). The observations were conducted with the VLA in C-configuration using five sessions from 2012 February 28 to April 16. Spectral line data used 2048 channels across 8MHz, yielding a channel spacing of 3.90625kHz at the central frequency of 6.6685192GHz and a velocity resolution of 0.176km/s. The continuum observations employed two 1GHz sub-bands from 4.9840 to 6.0080GHz (the low band) and from 6.6245 to 7.6485GHz (the high band) and each sub-band was divided into 16 channels. (4 data files).

VizieR Online Data Catalog: Galactic HII region IRAS 16148-5011 content (Mallick+, 2015)

NASA Astrophysics Data System (ADS)

Mallick, K. K.; Ojha, D. K.; Tamura, M.; Linz, H.; Samal, M. R.; Ghosh, S. K.

2015-11-01

NIR photometric observations in J (1.25um), H (1.63um), and Ks (2.14um) bands (centred on RA=16:18:31, DE=-50:17:32 (2000)) were carried out on 2004 July 29 using the 1.4m Infrared Survey Facility (IRSF) telescope, South Africa. The observations were taken with the help of the Simultaneous InfraRed Imager for Unbiased Survey (SIRIUS) instrument, a three colour simultaneous camera mounted at the f/10 Cassegrain focus of the telescope. Radio continuum observations at 1280MHz were obtained on 2012 November 09 using the Giant Metrewave Radio Telescope (GMRT) array. The GMRT array consists of 30 antennas arranged in an approximate Y-shaped configuration, with each antenna having a diameter of 45m. This translates to a primary beam-size of 26.2-arcmin at 1280MHz. (2 data files).

Florid urticarial vasculitis heralding a flare up of ulcerative colitis.

PubMed

Boules, Evon; Lyon, Calum

2014-12-22

A 75-year-old man with ulcerative colitis (UC) and diet controlled diabetes mellitus presented with a 3-week history of slightly itchy, red plaques on both lower limbs ascending gradually to cover the trunk and arms. One week later, he developed a flare up of his UC. Routine blood tests showed modest drop in haemoglobin (122 g/L) and C reactive protein (85 mg/L). Serology was remarkable for high antiproteinase 3 (c-ANCA). Serum electrophoresis showed a mildly positive paraprotein band (γ region). Stool culture was negative. Urine analysis showed proteinuria. Skin biopsy showed features of urticarial vasculitis (UV). He underwent a flexible sigmoidoscopy after the flare up showed mildly active UC. The patient was given hydrocortisone for 7 days and then prednisolone. Both rash and UC subsided. Electrophoresis was repeated 4 weeks later showing normal pattern. Prednisolone has been gradually reduced. Although rare, UV can be considered as one of the skin manifestations of UC. 2014 BMJ Publishing Group Ltd.

Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.

PubMed

Venkateswaran, Suresh; Prince, Jarod; Cutler, David J; Marigorta, Urko M; Okou, David T; Prahalad, Sampath; Mack, David; Boyle, Brendan; Walters, Thomas; Griffiths, Anne; Sauer, Cary G; LeLeiko, Neal; Keljo, David; Markowitz, James; Baker, Susan S; Rosh, Joel; Pfefferkorn, Marian; Heyman, Melvin B; Patel, Ashish; Otley, Anthony; Baldassano, Robert; Noe, Joshua; Rufo, Paul; Oliva-Hemker, Maria; Davis, Sonia; Zwick, Michael E; Gibson, Greg; Denson, Lee A; Hyams, Jeffrey; Kugathasan, Subra

2018-03-19

The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84-1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59). To study the genetic contribution to exclusive pediatric onset UC, a GWAS was performed on 466 cases with 2099 healthy controls using UK Biobank array. SNP2HLA was used to impute classical HLA alleles and their corresponding amino acids, and the results are compared with adult onset UC. HLA explained the almost entire association signal, dominated with 191 single nucleotide polymorphisms (SNPs) (p = 5 x 10-8 to 5 x 10-10). Although very small effects, established SNPs in adult onset UC loci had similar direction and magnitude in pediatric onset UC. SNP2HLA imputation identified HLA-DRB1*0103 (odds ratio [OR] = 6.941, p = 1.92*10-13) as the most significant association for pediatric UC compared with adult onset UC (OR = 3.59). Further conditioning showed independent effects for HLA-DRB1*1301 (OR = 2.25, p = 7.92*10-9) and another SNP rs17188113 (OR = 0.48, p = 7.56*10-9). Two HLA-DRB1 causal alleles are shared with adult onset UC, while at least 2 signals are unique to pediatric UC. Subsequent stratified analyses indicated that HLA-DRB1*0103 has stronger association for extensive disease (E4: OR = 8.28, p = 4.66x10-10) and female gender (OR = 8.85, p = 4.82x10-13). In pediatric onset UC, the HLA explains almost the entire genetic associations. In addition, the HLA association is approximately twice as strong in pediatric UC compared with adults, due to a combination of novel and shared effects. We speculate the paramount importance of antigenic stimulation either by infectious or noninfectious stimuli as a causal event in pediatric UC onset.

Stability and adaptability of popcorn genotypes in the State of Rio de Janeiro, Brazil.

PubMed

Pena, G F; do Amaral, A T; Gonçalves, L S A; Candido, L S; Vittorazzi, C; Ribeiro, R M; Freitas, S P

2012-08-31

This study aimed to obtain estimates of stability and adaptability of phase launched materials and materials recommended in the country, for the northern and northwestern regions of Rio de Janeiro State, Brazil, and made a comparative analysis of different methods to evaluate stability and adaptability of grain yield and popping expansion. To this end, 10 genotypes were evaluated (UNB2U-C3, UNB2U-C4, BRS Angela, Viçosa, Beija-Flor, IAC 112, IAC 125, Zélia, Jade, and UFVM2 Barão de Viçosa) in five environments. The Yates and Cochran method revealed that genotypes UFV2M Barão de Viçosa, BRS Angela and UNB2U-C3 were the most stable for grain yield. This method also indicated superiority of genotypes UNB2U-C3, UNB2U-C4, BRS Angela, Viçosa, IAC 125, and Zélia for popping expansion. The Plaisted and Peterson and Wricke methods demonstrated that genotypes Zélia and UNB2U-C4 were the most productive and stable. These methods indicated genotypes UNB2U-C3 and BRS Angela as the most stable for popping expansion. The Kang and Phan ranking system uses methods based on analysis of variance and classified population UNB2U-C4 as the genotype with the highest stability of grain production and confirmed cultivar BRS Angela as the most stable for popping expansion. Genotypes IAC 112 and UNB2U-C4 were the most stable and adapted for grain yield, according to the Lin and Binns method. The P(i) statistics also ranked UNB2U-C3 and UNB2U-C4 as the genotypes with the best predictability and capacity for popping expansion.

Creep behavior of uranium carbide-based alloys

NASA Technical Reports Server (NTRS)

Seltzer, M. S.; Wright, T. R.; Moak, D. P.

1975-01-01

The present work gives the results of experiments on the influence of zirconium carbide and tungsten on the creep properties of uranium carbide. The creep behavior of high-density UC samples follows the classical time-dependence pattern of (1) an instantaneous deformation, (2) a primary creep region, and (3) a period of steady-state creep. Creep rates for unalloyed UC-1.01 and UC-1.05 are several orders of magnitude greater than those measured for carbide alloys containing a Zr-C and/or W dispersoid. The difference in creep strength between alloyed and unalloyed materials varies with temperature and applied stress.

Molecules, dust, and protostars in NGC 3503

NASA Astrophysics Data System (ADS)

Duronea, N. U.; Vasquez, J.; Romero, G. A.; Cappa, C. E.; Barbá, R.; Bronfman, L.

2014-05-01

Aims: We present here a follow-up study of the molecular gas and dust in the environs of the star forming region NGC 3503. This study aims at dealing with the interaction of the Hii region NGC 3503 with its parental molecular cloud, and also with the star formation in the region, that was possibly triggered by the expansion of the ionization front against the parental cloud. Methods: To analyze the molecular gas we use CO(J = 2 → 1), 13CO(J = 2 → 1), C18O(J = 2 → 1), and HCN(J = 3 → 2) line data obtained with the on-the-fly technique from the APEX telescope. To study the distribution of the dust, we make use of unpublished images at 870 μm from the ATLASGAL survey and IRAC-GLIMPSE archival images. We use public 2MASS and WISE data to search for infrared candidate young stellar objects (YSOs) in the region. Results: The new APEX observations allowed the substructure of the molecular gas in the velocity range from ~-28 km s-1 to -23 km s-1 to be imaged in detail. The morphology of the molecular gas close to the nebula, the location of the PDR, and the shape of radio continuum emission suggest that the ionized gas is expanding against its parental cloud, and confirm the champagne flow scenario. We have identified several molecular clumps and determined some of their physical and dynamical properties such as density, excitation temperature, mass, and line width. Clumps adjacent to the ionization front are expected to be affected by the Hii region, unlike those that are distant from it. We have compared the physical properties of the two kinds of clumps to investigate how the molecular gas has been affected by the Hii region. Clumps adjacent to the ionization fronts of NGC 3503 and/or the bright rimmed cloud SFO 62 have been heated and compressed by the ionized gas, but their line width is not different from those that are too distant from the ionization fronts. We identified several candidate YSOs in the region. Their spatial distribution suggests that stellar

Urothelial carcinoma involving the distal penis.

PubMed

Dason, Shawn; Sheikh, Adeel; Wang, Jing Gennie; Tauqir, Syeda; Davies, Timothy O; Shayegan, Bobby

2012-04-01

Urothelial carcinoma (UC) rarely metastasizes to the penis and skin. We report the case of a 73-year-old man with UC metastases to the corpus spongiosum and dermis of the distal penis. We also review the clinicopathologic characteristics and management options for UC metastasizing to the penis. The patient presented with priapism and edema of the genital region. This follows a 5-year history of urothelial carcinoma in situ that progressed to invasive cancer despite intravesical immunotherapy. Seventeen months prior to presentation, the patient underwent a radical cystectomy with adjuvant chemotherapy. The cystectomy specimen demonstrated a pT4a N2 M0 G3 UC and margins were positive for carcinoma in situ. Follow-up had been negative for recurrence until his presentation with priapism. Incisional biopsy of the glans revealed UC and radical penectomy was performed with negative margins. The penile specimen demonstrated extensive involvement of the corpus spongiosum by UC with lymphovascular invasion and subepidermal involvement. Three months after penectomy, the patient presented with inguinal nodal recurrence. Palliative radiotherapy was administered and the patient passed away eight months after surgery.

NuSTAR Search for Hard X-ray Emission from the Star Formation Regions in Sh2-104

NASA Astrophysics Data System (ADS)

Gotthelf, Eric V.

2016-04-01

We present NuSTAR hard X-ray observations of Sh2-104, a compact Hii region containing several young massive stellar clusters (YMSCs). We have detected distinct hard X-ray sources coincident with localized VERITAS TeV emission recently resolved from the giant gamma-ray complex MGRO J2019+37 in the Cygnus region. Faint, diffuse X-ray emission coincident with the eastern YMSC in Sh2-104 is likely the result of colliding winds of component stars. Just outside the radio shell of Sh2-104 lies 3XMM J201744.7+365045 and nearby nebula NuSTAR J201744.3+364812, whose properties are most consistent with extragalactic objects. The combined XMM-Newton and NuSTAR spectrum of 3XMM J201744.7+365045 is well-fit to an absorbed power-law model with NH = (3.1+/-1.0)E22 1/cm^2 and photon index Gamma = 2.1+/-0.1. Based on possible long-term flux variation and lack of detected pulsations (<43% modulation), this object is likely a background AGN rather than a Galactic pulsar. The spectrum of the NuSTAR nebula shows evidence of an emission line at E = 5.6 keV suggesting an optically obscured galaxy cluster at z = 0.19+/-0.02 (d = 800 Mpc) and Lx = 1.2E44 erg/s. Follow-up Chandra observations of Sh2-104 will help identify the nature of the X-ray sources and their relation to MGRO J2019+37.

Prevalence of inflammatory bowel disease in two districts of Sri Lanka: a hospital based survey

PubMed Central

2010-01-01

Background Inflammatory bowel disease (IBD) is being increasingly diagnosed in Asia. However there are few epidemiological data from the region. Methods To determine prevalence and clinical characteristics of IBD, a hospital-based survey was performed in the Colombo and Gampaha districts (combined population 4.5 million) in Sri Lanka. Patients with established ulcerative colitis (UC) and Crohn's disease (CD), who were permanent residents of these adjoining districts, were recruited from hospital registries and out-patient clinics. Clinical information was obtained from medical records and patient interviews. Results There were 295 cases of IBD (UC = 240, CD = 55), of which 34 (UC = 30, CD = 4) were newly diagnosed during the study year. The prevalence rate for UC was 5.3/100,000 (95% CI 5.0-5.6/100,000), and CD was 1.2/100,000 (95% CI 1.0-1.4/100,000). The incidence rates were 0.69/100,000 (95% CI 0.44-0.94/100,000) for UC and 0.09/100,000 (95% CI 0.002-0.18/100,000) for CD. Female:male ratios were 1.5 for UC and 1.0 for CD. Mean age at diagnosis was (males and females) 36.6 and 38.1y for UC and 33.4 and 36.2y for CD. Among UC patients, 51.1% had proctitis and at presentation 58.4% had mild disease. 80% of CD patients had only large bowel involvement. Few patients had undergone surgery. Conclusions The prevalence of IBD in this population was low compared to Western populations, but similar to some in Asia. There was a female preponderance for UC. UC was mainly mild, distal or left-sided, while CD mainly involved the large bowel. PMID:20302651

Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis.

PubMed

Iwamoto, Taku; Yashima, Kazuo; Morio, Keiko; Ueda, Naoki; Ikebuchi, Yuichiro; Kawaguchi, Koichiro; Harada, Kenichi; Isomoto, Hajime

2018-03-01

The human leukocyte antigen (HLA) region has been found to be involved in the pathogenesis of inflammatory bowel disease (IBD), which is classified into ulcerative colitis (UC) and Crohn's disease (CD), by genome-wide association studies. The aim of this study was to confirm whether HLA-alleles confer susceptibility to UC and to determine whether HLA-allel1es are associated with the clinical phenotypes in Japanese patients with UC. In this study, HLA typing was performed by PCR-sequence-specific oligonucleotides (PCR-SSO) to confirm the correlation between UC and HLA alleles (for HLA-A, B, DRB1) in 45 Japanese UC patients. In addition, whether the HLA alleles are related to patient and clinical background characteristics was examined. Overall, 62.2%, and 66.7% of the 45 UC patients had HLA-B*52 and HLA-DRB1*15, respectively. These allele frequencies were significantly higher than in previously reported Japanese control persons ( P < 0.0001). The frequencies of extraintestinal manifestations [odds ratio (OR) = 0.12, P = 0.039] and a history of colectomy (OR = 0.18, P = 0.046) were lower in HLA-B*52-positive UC patients than in HLA-B*52 negative UC patients. The white blood cell (WBC) count was significantly higher in HLA-DRB1*15-positive patients (9430 ± 4592/μL) than in HLA-DRB1*15-negative patients (6729 ± 2160/μL). Thus, HLA-B*52 and DRB1*15 appear to be associated with disease features and severity in Japanese UC patients. These results indicate that HLA-B*52 and DRB1*15 are not only associated with overall UC susceptibility, but also with the clinical phenotypes in Japanese patients.

Sub-mm CO Measurements of the Orion Molecular Cloud

NASA Astrophysics Data System (ADS)

Wilson, T. L.; Muders, D.; Kramer, C.; Henkel, C.

2000-05-01

Images of a >3' region around the Orion KL source have been made in the J=4-3 (461 GHz) and J=7-6 (806 GHz) lines of CO with angular resolutions of 18'' and 13'', using the 10-meter Heinrich Hertz Telescope (HHT) of the Sub-Millimeter Telescope Observatory (SMTO). This region contains a variety of objects: (1) the Hot Core (a region containing complex molecules) and Orion KL outflow (NE of the center of the 10'' diameter Hot Core, and very likely associated with the continuum source `I' (Menten & Reid 1995 ApJ 445, L157)), (2) another outflow source, Orion-S ( ~100'' south of the Hot Core (Rodriguez-Franco et al. 1999 A&A 344, L57)), (3) the ionized-neutral interface at the rear of the Orion HII region, and (4) the Orion Bar feature (an ionized-neutral interface to the SW of the HII region). Regions (3) and (4) are examples of `Photon Dominated Regions' or `PDR's'. The sub-mm CO lines are emitted from warm gas; the J=7-6 line is emitted from an energy level 156 Kelvin above the ground state. The excellent pointing and low sidelobes of the HHT allow accurate comparisons with high r! esolution CO images in lower J lines and images of other species. Our J=7-6 CO image was made with the Harvard-Smithsonian Center for Astrophysics Hot Electron Bolometer (Kawamura et al. 1999 IEEE Trans. on Appl. Superconductivity 9, 3753. The HHT is operated by the Submillimeter Telescope Observatory on behalf of the Max-Planck-Institut f. Radioastronomie and Steward Observatory of The University of Arizona. We thank the CfA receiver group for providing the Hot Electron Bolometer used to take the J=7-6 CO line data.

VizieR Online Data Catalog: Diffuse ionized gas in the Antennae galaxy (Weilbacher+, 2018)

NASA Astrophysics Data System (ADS)

Weilbacher, P. M.; Monreal-Ibero, A.; Verhamme, A.; Sandin, C.; Steinmetz, M.; Kollatschny, W.; Krajnovic, D.; Kamann, S.; Roth, M. M.; Erroz-Ferrer, S.; Marino, R. A.; Maseda, M. V.; Wendt, M.; Bacon, R.; Dreizler, S.; Richard, J.; Wisotzki, L.

2017-11-01

We provide two-dimensional maps of two different ways to measure the diffuse ionized gas as traced by the Halpha emission line in the Antennae Galaxy, both for the central field and the field at the end of the southern tidal tail. We provide a velocity map derived from the Halpha emission line, binned to a S/N~30. Finally, we provide line measurements and derived properties for all HII regions discussed in the paper. (4 data files).

Magnetic Fields in the Galaxy

NASA Astrophysics Data System (ADS)

Mayo, Elizabeth A.

2009-01-01

Interstellar magnetic fields are believed to play a crucial role in the star-formation process, therefore a comprehensive study of magnetic fields is necessary in understanding the origins of stars. These projects use observational data obtained from the Very Large Array (VLA) in Socorro, NM. The data reveal interstellar magnetic field strengths via the Zeeman effect in radio frequency spectral lines. This information provides an estimate of the magnetic energy in star-forming interstellar clouds in the Galaxy, and comparisons can be made with these energies and the energies of self-gravitation and internal motions. From these comparisons, a better understanding of the role of magnetic fields in the origins of stars will emerge. NGC 6334 A is a compact HII region at the center of what is believed to be a large, rotating molecular torus (Kramer et al. (1997)). This is a continuing study based on initial measurements of the HI and OH Zeeman effect (Sarma et al. (2000)). The current study includes OH observations performed by the VLA at a higher spatial resolution than previously published data, and allows for a better analysis of the spatial variations of the magnetic field. A new model of the region is also developed based on OH opacity studies, dust continuum maps, radio spectral lines, and infrared (IR) maps. The VLA has been used to study the Zeeman effect in the 21cm HI line seen in absorption against radio sources in the Cygnus-X region. These sources are mostly galactic nebulae or HII regions, and are bright and compact in this region of the spectrum. HI absorption lines are strong against these regions and the VLA is capable of detecting the weak Zeeman effect within them. Support for this work was provided by the NSF PAARE program to South Carolina State University under award AST-0750814.

Estructura, Cinemática y Condiciones Físicas del Merger NGC3256

NASA Astrophysics Data System (ADS)

Lípari, S.; Díaz, R. J.; Carranza, G.

We studied in detail the structure, the kinematics, and the physical conditions in the nuclear, central and external regions of the nearby merger and luminous IR source NGC 3256 (LIR = 3.3 × 1011Lsolar). Using broad-- (B, V, I) and narrow--band (Hα, [OIII]λ5007) images --obtained at ESO-NTT and CASLEO during march'89 to july'97-- we studied the properties of the main structures in this merger. In particular, we analyzed in detail the giant HII regions which are extended in the nuclear and central region of NGC 3256 and are probably associated to a massive starburst originated in the merger process of two gas rich spirals galaxies.

The israeli virtual national health record: a robust national health information infrastructure based on a firm foundation of trust.

PubMed

Saiag, Esther

2005-01-01

In many developed countries, a coordinated effort is underway to build national and regional Health Information Infrastructures (HII) for the linking of disparate sites of care, so that an access to a comprehensive Health Record will be feasible when critical medical decisions are made [1]. However, widespread adoption of such national projects is hindered by a series of barriers- regulatory, technical, financial and cultural. Above all, a robust national HII requires a firm foundation of trust: patients must be assured that their confidential health information will not be misused and that there are adequate legal remedies in the event of inappropriate behavior on the part of either authorized or unauthorized parties[2].The Israeli evolving National HII is an innovative state of the art implementation of a wide-range clinical inter-organizational data exchange, based on a unique concept of virtually temporary sharing of information. A logically connection of multiple caregivers and medical organizations creates a patient-centric virtual repository, without centralization. All information remains in its original format, location, system and ownership. On demand, relevant information is instantly integrated and delivered to the point of care. This system, successfully covering more than half of Israel's population, is currently evolving from a voluntary private-public partnership (dbMOTION and CLALIT HMO) to a formal national reality. The governmental leadership, now taking over the process, is essential to achieve a full potential of the health information technology. All partners of the Israeli health system are coordinated in concert with each other, driven with a shared vision - realizing that a secured, private, confidential health information exchange is assured.

The Distribution of Massive Stars in M101

NASA Astrophysics Data System (ADS)

Bibby, J.; Shara, M.; Zurek, D.; Crowther, P. A.; Moffat, A. F. J.; Drissen, L.; Wilde, M.

75 WR stars and 164 RSGs are identified in a single WFC3 pointing of our M101 survey. We find that within it's large star-forming complex NGC 5462 WR stars are preferentially located in the core whilst RSGs are found in the halo, suggesting two bursts of star-formation. A review of our WR candidates reveals that only ˜30% are detected in the archival broad-band ACS imaging whilst only ˜50% are associated with HII regions.

The Photoevaporation of a Neutral Structure by an EUV+FUV Radiation Field

NASA Astrophysics Data System (ADS)

Lora, Veronica; Vasconcelos, M. J.; Raga, A. C.; Cerqueira, A. H.; Esquivel, A.

The expansion of an HII region into a surrounding inhomogeneous molecular cloud, leads to the formation of elongated "elephant trunk" structures. The EUV photo-ionising radiation and FUV dissociating radiation from newly born stars photo-evaporate their parental neutral cloud, leading to the formation of dense clumps in the tips of elephant trunks, that could in principle eventually form stars. We study th effects of including a photo-dissociating FUV flux in models of fragmentation of a photo-evaporating, self-gravitating molecular cloud.

The annihilation of galactic positrons

NASA Technical Reports Server (NTRS)

Bussard, R.; Rematy, R.

1978-01-01

The probabilities of various channels of galactic positron annihilation were evaluated and the spectrum of the resulting radiation was calculated. The narrow width (FWHM less than 3.2 keV) of the 0.511 MeV line observed from the galactic center implies that a large fraction of positrons should annihilate in a medium of temperature less than 100,000 K and ionization fraction greater than 0.05. HII regions at the galactic center could be possible sites of annihilation.

High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial.

PubMed

Aoun, Mabel; Makki, Maha; Azar, Hiba; Matta, Hiam; Chelala, Dania Nehme

2017-06-07

Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular calcifications. Supplementation of hemodialysis patients with vitamin K 2 (menaquinone-7) has been studied in Europe with a maximum 61% drop of dp-ucMGP levels. The aim of this study is to assess first the drop of dp-ucMGP in an Eastern Mediterranean cohort after vitamin K 2 treatment and second the correlation between baseline dp-ucMGP and vascular calcification score. This is a prospective, pre-post intervention clinical trial involving 50 hemodialysis patients who received daily 360 μg of menaquinone-7 for 4 weeks. At baseline they were assessed for plasma dp-ucMGP levels and vascular calcification scores (AC-24) as well as for other demographic, clinical and biological variables. Dp-ucMGP levels were measured a second time at 4 weeks. At baseline, dp-ucMGP levels were extremely elevated with a median of 3179.15 (1825.25; 4339.50) pM and correlated significantly with AC-24 (Spearman's rho = 0.43, P = 0.002). Using a bivariate regression analysis, the association between dp-ucMGP levels and AC-24 was most significant when comparing dp-ucMGP levels less than 1000 to those more than 1000 pM (P = 0.02). Dp-ucMGP levels higher than 5000 pM were significantly associated with females, patients with recent fracture and patients with lower serum albumin (respectively P = 0.02, 0.004 and 0.046). The average drop of dp-ucMGP at 4 weeks of treatment was found to be 86% with diabetics having the lowest drop rate (P = 0.01). Vitamin K deficiency, as assessed by high dp-ucMGP levels, is profound in hemodialysis patients from the Eastern Mediterranean region and it is significantly correlated with vascular calcifications. Daily 360 μg of menaquinone-7, given for 4 weeks, effectively reduces dp-ucMGP in this population. Future studies are needed to assess

Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis

PubMed Central

Nahar, Saifun; Iraha, Atsushi; Hokama, Akira; Uehara, Ayako; Parrott, Gretchen; Ohira, Tetsuya; Kaida, Masatoshi; Kinjo, Tetsu; Kinjo, Takeshi; Hirata, Tetsuo; Kinjo, Nagisa; Fujita, Jiro

2015-01-01

AIM: To evaluate a multiplex PCR assay for the detection of bacterial and viral enteropathogens in stool samples from patients with ulcerative colitis (UC). METHODS: We prospectively analyzed 300 individuals, including immunocompetent patients, immunocompromised patients, and patients with UC. Stool samples were collected from the recto-sigmoid region of the colon by endoscopy. The samples were qualitatively analyzed for bacterial and viral enteropathogens with a multiplex PCR assay using a Seeplex® Kit. Additional clinical and laboratory data were collected from the medical records. RESULTS: A multiplex PCR assay detected 397 pathogens (191 bacteria and 206 viruses) in 215 samples (71.7%). The most frequently detected bacteria were Escherichia coli H7, 85 (28.3%); followed by Aeromonas spp., 43 (14.3%); and Clostridium perfringens, 36 (12.0%) samples. The most prevalent viruses were Epstein-Barr virus (EBV), 90 (30.0%); followed by human herpes virus-6 (HHV-6), 53 (17.7%); and cytomegalovirus (CMV), 37 (12.3%) samples. The prevalence rate of CMV infection was significantly higher in the immunocompromised group than in the immunocompetent group (P < 0.01). CMV infection was more common in patients with UC (26/71; 36.6%) than in the immunocompetent patients excluding UC (6/188; 3.2%) (P < 0.01). CMV infection was more prevalent in UC active patients (25/58; 43.1%) than in UC inactive patients (1/13; 7.7%) (P < 0.05). Among 4 groups which defined by the UC activity and immunosuppressive drugs, the prevalence rate of CMV infection was highest in the UC active patients with immunosuppressive drugs (19/34; 55.8%). Epstein-Barr virus (EBV) infection was more common in the immunocompromised patients excluding UC (18/41; 43.9%) than in the immunocompetent patients excluding UC (47/188; 25.0%) (P < 0.05). The simultaneous presence of CMV and EBV and/or HHV6 in UC active patients (14/58; 24.1%) was greater than in immunocompromised patients excluding UC (5/41; 12.2%) (P < 0

First Detection of the [O(sub III)] 88 Micrometers Line at High Redshifts: Characterizing the Starburst and Narrow-Line Regions in Extreme Luminosity Systems

NASA Technical Reports Server (NTRS)

Ferkinhoff, C.; Hailey-Dunsheath, S.; Nikola, T.; Parshley, S. C.; Stacey, G. J.; Benford, D. J.; Staguhn, J. G.

2010-01-01

We have made the first detections of the 88 micrometers [O(sub III)] line from galaxies in the early universe, detecting the line from the lensed active galactic nucleus (AGN)/starburst composite systems APM 08279+5255 at z 3.911 and SMM J02399-0136 at z = 2.8076. The line is exceptionally bright from both systems, with apparent (lensed) luminosities approx.10(exp 11) Solar Luminosity, For APM 08279, the [O(sub III)] line flux can be modeled in a star formation paradigm, with the stellar radiation field dominated by stars with effective temperatures, T(sub eff) > 36,000 K, similar to the starburst found in M82. The model implies approx.35% of the total far-IR luminosity of the system is generated by the starburst, with the remainder arising from dust heated by the AGN. The 881,tm line can also be generated in the narrow-line region of the AGN if gas densities are around a few 1000 cu cm. For SMM J02399, the [O(sub III)] line likely arises from HII regions formed by hot (T(sub eff) > 40,000 K) young stars in a massive starburst that dominates the far-IR luminosity of the system. The present work demonstrates the utility of the [O(sub III)] line for characterizing starbursts and AGN within galaxies in the early universe. These are the first detections of this astrophysically important line from galaxies beyond a redshift of 0.05.s

U.S. Department of Energy Pacific Region Clean Energy Application Center (PCEAC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lipman, Tim; Kammen, Dan; McDonell, Vince

2013-09-30

The U.S. Department of Energy Pacific Region Clean Energy Application Center (PCEAC) was formed in 2009 by the U.S. Department of Energy (DOE) and the California Energy Commission to provide education, outreach, and technical support to promote clean energy -- combined heat and power (CHP), district energy, and waste energy recovery (WHP) -- development in the Pacific Region. The region includes California, Nevada, Hawaii, and the Pacific territories. The PCEAC was operated as one of nine regional clean energy application centers, originally established in 2003/2004 as Regional Application Centers for combined heat and power (CHP). Under the Energy Independence andmore » Security Act of 2007, these centers received an expanded charter to also promote district energy and waste energy recovery, where economically and environmentally advantageous. The centers are working in a coordinated fashion to provide objective information on clean energy system technical and economic performance, direct technical assistance for clean energy projects and additional outreach activities to end users, policy, utility, and industry stakeholders. A key goal of the CEACs is to assist the U.S. in achieving the DOE goal to ramp up the implementation of CHP to account for 20% of U.S. generating capacity by 2030, which is estimated at a requirement for an additional 241 GW of installed clean technologies. Additional goals include meeting the Obama Administration goal of 40 GW of new CHP by 2020, key statewide goals such as renewable portfolio standards (RPS) in each state, California’s greenhouse gas emission reduction goals under AB32, and Governor Brown’s “Clean Energy Jobs Plan” goal of 6.5 GW of additional CHP over the next twenty years. The primary partners in the PCEAC are the Department of Civil and Environmental Engineering and the Energy and Resources Group (ERG) at UC Berkeley, the Advanced Power and Energy Program (APEP) at UC Irvine, and the Industrial Assessment

Summer School on Interstellar Processes: Abstracts of contributed papers

NASA Technical Reports Server (NTRS)

Hollenbach, D. J. (Editor); Thronson, H. A., Jr. (Editor)

1986-01-01

The Summer School on Interstellar Processes was held to discuss the current understanding of the interstellar medium and to analyze the basic physical processes underlying interstellar phenomena. Extended abstracts of the contributed papers given at the meeting are presented. Many of the papers concerned the local structure and kinematics of the interstellar medium and focused on such objects as star formation regions, molecular clouds, HII regions, reflection nebulae, planetary nebulae, supernova remnants, and shock waves. Other papers studied the galactic-scale structure of the interstellar medium either in the Milky Way or other galaxies. Some emphasis was given to observations of interstellar grains and

Thackeray's Globules in IC 2944

NASA Technical Reports Server (NTRS)

2002-01-01

Strangely glowing dark clouds float serenely in this remarkable and beautiful image taken with NASA's Hubble Space Telescope. These dense, opaque dust clouds - known as 'globules' - are silhouetted against nearby bright stars in the busy star-forming region, IC 2944. These globules were first found in IC 2944 by astronomer A.D. Thackeray in 1950. Although globules like these have been known since Dutch-American astronomer Bart Bok first drew attention to such objects in 1947, little is still known about their origin and nature, except that they are generally associated with areas of star formation, called 'HII regions' due to the presence of hydrogen gas. The largest of the globules in this image is actually two separate clouds that gently overlap along our line of sight. Each cloud is nearly 1.4 light-years (50 arcseconds) along its longest dimension, and collectively, they contain enough material to equal over 15 solar masses. IC 2944, the surrounding HII region, is filled with gas and dust that is illuminated and heated by a loose cluster of O-type stars. These stars are much hotter and much more massive than our Sun. IC 2944 is relatively close by, located only 5900 light-years (1800 parsecs) away in the constellation Centaurus. Thanks to the remarkable resolution offered by the Hubble Space Telescope, astronomers can for the first time study the intricate structure of these globules. The globules appear to be heavily fractured, as if major forces were tearing them apart. When radio astronomers observed the faint hiss of molecules within the globules, they realized that the globules are actually in constant, churning motion, moving supersonically among each other. This may be caused by the powerful ultraviolet radiation from the luminous, massive stars, which also heat up the gas in the HII region, causing it to expand and stream against the globules, leading to their destruction. Despite their serene appearance, the globules may actually be likened to clumps

Studies on the organization and regeneration of bone marrow: origin, growth, and differentiation of endocloned hematopoietic colonies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lambertsen, R.H.; Weiss, L.

1983-04-01

Hematopoietic colonies were studied by light microscopy in the marrow of alternate fraction x-irradiated mice (C576J/B1) to investigate the microenvironmental organization of marrow and identify early hematopoietic cell-stromal cell interactions. Undifferentiated colonies (UC) were detected at 3 days postirradiation, showed a marked predilection for bone surfaces, and disappeared as differentiated colonies developed. Some UC occurred along marrow arteries. Neutrophilic granulocyte colonies (GC) occurred in all areas at 3 days but grew rapidly only subosteally. Few eosinophilic colonies (GCe) occurred. Erythrocytic colonies (EC) appeared at 4 days as dispersed populations of motile cells within a localized area of marrow; these tendedmore » to proliferate initially in intermediate and central marrow zones. Macrophage colonies (M phi C) of two ''subtypes'' were detected, peaking in relative frequency at 4 days. These appeared active in stromal repair and monocytopoiesis. Megakaryocyte colonies (MC) originated along bone and differentiated away from bone. These results were interpreted as evidence that in x-irradiated marrow: (1) hematopoietic microenvironments (HMs) for stem-cell proliferation and commitment to differentiation, with the possible exception of HMs determining erythroid differentiation, occur in endosteal and periarterial regions; (2) a proliferative and/or chemotactic stimulus to erythroid progenitors exists in intermediate and central marrow regions; and (3) some subosteal regions may exclude erythropoiesis, or preferentially support nonerythroid differentiation. Elaborate associations occurred between macrophages and early UC, GC, and EC, but not MC hematopoietic cells. UC and GC often associated with osteoclasts. Reticular and other fibroblastic cells associated with the cells of all colony types.« less

New Triplet Sensitization Routes for Photon Upconversion: Thermally Activated Delayed Fluorescence Molecules, Inorganic Nanocrystals, and Singlet-to-Triplet Absorption.

PubMed

Yanai, Nobuhiro; Kimizuka, Nobuo

2017-10-17

Photon upconversion based on triplet-triplet annihilation (TTA-UC) has attracted much interest because of its possible applications to renewable energy production and biological fields. In particular, the UC of near-infrared (NIR) light to visible (vis) light is imperative to overcome the Shockley-Queisser limit of single-junction photovoltaic cells, and the efficiency of photocatalytic hydrogen production from water can also be improved with the aid of vis-to-ultraviolet (UV) UC. However, both processes have met limitations in the wavelength range, efficiency, and sensitivity for weak incident light. This Account describes recent breakthroughs that solve these major problems, new triplet sensitization routes to significantly enlarge the range of conversion wavelength by minimizing the energy loss during intersystem crossing (ISC) of triplet sensitizers or bypassing the ISC process. The photochemical processes of TTA-UC in general start with the absorption of longer wavelength incident light by triplet sensitizers, which generate the triplet states via ISC. This ISC inevitably accompanies the energy loss of hundreds of millielectronvolts, which significantly limits the TTA-UC with large anti-Stokes shifts. The small S 1 -T 1 gap of molecules showing thermally activated delayed fluorescence (TADF) allows the sensitization of emitters with the highest T 1 and S 1 energy levels ever employed in TTA-UC, which results in efficient vis-to-UV UC. As alternatives to molecular sensitizers in the NIR region, inorganic nanocrystals with broad NIR absorption bands have recently been shown to work as effective sensitizers for NIR-to-vis TTA-UC. Their small exchange splitting minimizes the energy loss during triplet sensitization. The modification of nanocrystal surfaces with organic acceptors via coordination bonds allows efficient energy transfer between the components and succeeding TTA processes. To remove restrictions on the energy loss during ISC, molecules with direct

On the Measurement of Elemental Abundance Ratios in Inner Galaxy H II Regions

NASA Technical Reports Server (NTRS)

Simpson, Janet P.; Rubin, Robert H.; Colgan, Sean W. J.; Erickson, Edwin F.; Haas, Michael R.

2004-01-01

Although abundance gradients in the Milky Way Galaxy certainly exist, details remain uncertain, particularly in the inner Galaxy, where stars and H II regions in the Galactic plane are obscured optically. In this paper we revisit two previously studied, inner Galaxy H II regions: G333.6-0.2 and W43. We observed three new positions in G333.6-0.2 with the Kuiper Airborne Observatory and reobserved the central position with the Infrared Space Observatory's Long Wavelength Spectrometer in far-infrared lines of S++, N++, N+, and O++. We also added the N+ lines at 122 and 205 microns to the suite of lines measured in W43 by Simpson et al.. The measured electron densities range from approx. 40 to over 4000 per cu cm in a single HII region, indicating that abundance analyses must consider density variations, since the critical densities of the observed lines range from 40 to 9000 per cu cm. We propose a method to handle density variations and make new estimates of the S/H and N/H abundance ratios. We find that our sulfur abundance estimates for G333.6-0.2 and W43 agree with the S/H abundance ratios expected for the gradient previously reported by Simpson et al., with the S/H values revised to be smaller owing to changes in collisional excitation cross sections. The estimated N/H, S/H, and N/S ratios are the most reliable because of their small corrections for unseen ionization states (< or approx. 10%). The estimated N/S ratios for the two sources are smaller than what would be calculated from the N/H and S/H ratios in our previous paper. If all low excitation H II regions had similar changes to their N/S ratios as a result of adding measurements of N+ to previous measurements of N++, there would be no or only a very small gradient in N/S. This is interesting because nitrogen is considered to be a secondary element and sulfur is a primary element in galactic chemical evolution calculations. We compute models of the two H II regions to estimate corrections for the other

Lithostratigraphy, biostratigraphy and chemostratigraphy of Upper Cretaceous sediments from southern Tanzania: Tanzania drilling project sites 21-26

NASA Astrophysics Data System (ADS)

Jiménez Berrocoso, Álvaro; MacLeod, Kenneth G.; Huber, Brian T.; Lees, Jacqueline A.; Wendler, Ines; Bown, Paul R.; Mweneinda, Amina K.; Isaza Londoño, Carolina; Singano, Joyce M.

2010-04-01

The 2007 drilling season by the Tanzania drilling project (TDP) reveals a much more expanded Upper Cretaceous sequence than was recognized previously in the Lindi region of southern Tanzania. This TDP expedition targeted recovery of excellently preserved microfossils (foraminifera and calcareous nannofossils) for Late Cretaceous paleoclimatic, paleoceanographic and biostratigraphic studies. A total of 501.17 m of core was drilled at six Upper Cretaceous sites (TDP Sites 21, 22, 23, 24, 24B and 26) and a thin Miocene-Pleistocene section (TDP Site 25). Microfossil preservation at all these sites is good to excellent, with foraminifera often showing glassy shells and consistently good preservation of small and delicate nannofossil taxa. In addition to adding to our knowledge of the subsurface geology, new surface exposures were mapped and the geological map of the region is revised herein. TDP Sites 24, 24B and 26 collectively span the upper Albian to lower-middle Turonian (planktonic foraminiferal Planomalina buxtorfi- Whiteinella archaeocretacea Zones and calcareous nannofossil zones UC0a-UC8a). The bottom of TDP Site 21 is barren, but the rest of the section represents the uppermost Cenomanian-Coniacian ( W. archaeocretacea- Dicarinella concavata Zones and nannofossil zones UC5c-UC10). Bulk organic δ 13C data suggest recovery of part of Ocean Anoxic Event 2 (OAE2) from these four sites. In the upper part of this interval, the lower Turonian nannofossil zones UC6a-7 are characterized by a low-diversity nannoflora that may be related to OAE2 surface-water conditions. TDP Site 22 presents a 122-m-thick, lower-middle Turonian ( W. archaeocretacea- Helvetoglobotruncana helvetica Zones) sequence that includes the nannofossil zones UC6a(-7?), but invariable isotopic curves. Further, a lower to upper Campanian ( Globotruncana ventricosa- Radotruncana calcarata Zones and nannofossil subzones UC15b TP-UC15d TP) succession was drilled at TDP Site 23. Lithologies of the new

Seasonal variation in the acute presentation of urinary calculi over 8 years in Auckland, New Zealand.

PubMed

Lo, Sum Sum; Johnston, Richard; Al Sameraaii, Ahmed; Metcalf, Patricia A; Rice, Michael L; Masters, Jonathan G

2010-07-01

Symptom prevalence (retrospective cohort) Level of Evidence 2b. To determine the incidence of acute presentation of urinary calculi (UC) in Auckland, New Zealand, during the period 1999-2007, and whether there was any significant seasonal variation. The details of all UC within the population presenting acutely to public hospitals in Auckland between 1999 and 2007 were collected using clinical coding searches International Classification of Disease 10th revision (Australian Modification) N132 and N20. Climatic variables for the Auckland region were obtained from the National Institute of Water and Atmospheric Research, New Zealand. The mean atmospheric temperature, hours of sunshine and humidity data were calculated monthly for this period. During the study there were 7668 acute presentations of UC in the Auckland region. A Poisson regression model showed that the number of presentations was significantly related to temperature (P < 0.001) and hours of sunshine (P = 0.004) but not humidity (P = 0.14). For each degree increase in temperature the number of presentations increased by 2.8% (95% confidence interval 1.3-4.3%). For each 1-h increase in sunshine, the number of presentations increased by 0.2% (0.06-0.33)%. The acute presentation of UC in Auckland, New Zealand, varies significantly with temperature and hours of sunshine. Humidity was not a significant factor.

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion.

PubMed

Santillán, Orlando; Ramírez-Romero, Miguel A; Dávila, Guillermo

2017-06-25

Here, we present chimera assembly by plasmid recovery and restriction enzyme site insertion (CAPRRESI). CAPRRESI benefits from many strengths of the original plasmid recovery method and introduces restriction enzyme digestion to ease DNA ligation reactions (required for chimera assembly). For this protocol, users clone wildtype genes into the same plasmid (pUC18 or pUC19). After the in silico selection of amino acid sequence regions where chimeras should be assembled, users obtain all the synonym DNA sequences that encode them. Ad hoc Perl scripts enable users to determine all synonym DNA sequences. After this step, another Perl script searches for restriction enzyme sites on all synonym DNA sequences. This in silico analysis is also performed using the ampicillin resistance gene (ampR) found on pUC18/19 plasmids. Users design oligonucleotides inside synonym regions to disrupt wildtype and ampR genes by PCR. After obtaining and purifying complementary DNA fragments, restriction enzyme digestion is accomplished. Chimera assembly is achieved by ligating appropriate complementary DNA fragments. pUC18/19 vectors are selected for CAPRRESI because they offer technical advantages, such as small size (2,686 base pairs), high copy number, advantageous sequencing reaction features, and commercial availability. The usage of restriction enzymes for chimera assembly eliminates the need for DNA polymerases yielding blunt-ended products. CAPRRESI is a fast and low-cost method for fusing protein-coding genes.

Navy Virginia (SSN 774) Class Attack Submarine Procurement: Background and Issues for Congress

DTIC Science & Technology

2016-10-25

proposed plan include the following:  GD/EB is to be the prime contractor for designing and building Ohio replacement boats;  HII/NNS is to be a...boats, and HII/NNS would receive 22%-23%;  GD/EB is to continue as prime contractor for the Virginia-class program, but to help balance out projected...execute this strategy, GDEB has been selected as the prime contractor for OR with the responsibilities to deliver the twelve OR [Ohio replacement

Measurement of the Ecological Integrity of Cerrado Streams Using Biological Metrics and the Index of Habitat Integrity

PubMed Central

dos Reis, Deusiano Florêncio; Salazar, Ayala Eduardo; Machado, Mayana Mendes Dias; Couceiro, Sheyla Regina Marques; de Morais, Paula Benevides

2017-01-01

Generally, aquatic communities reflect the effects of anthropogenic changes such as deforestation or organic pollution. The Cerrado stands among the most threatened ecosystems by human activities in Brazil. In order to evaluate the ecological integrity of the streams in a preserved watershed in the Northern Cerrado biome corresponding to a mosaic of ecosystems in transition to the Amazonia biome in Brazil, biological metrics related to diversity, structure, and sensitivity of aquatic macroinvertebrates were calculated. Sampling included collections along stretches of 200 m of nine streams and measurements of abiotic variables (temperature, electrical conductivity, pH, total dissolved solids, dissolved oxygen, and discharge) and the Index of Habitat Integrity (HII). The values of the abiotic variables and the HII indicated that most of the streams have good ecological integrity, due to high oxygen levels and low concentrations of dissolved solids and electric conductivity. Two streams showed altered HII scores mainly related to small dams for recreational and domestic use, use of Cerrado natural pasture for cattle raising, and spot deforestation in bathing areas. However, this finding is not reflected in the biological metrics that were used. Considering all nine streams, only two showed satisfactory ecological quality (measured by Biological Monitoring Working Party (BMWP), total richness, and EPT (Ephemeroptera, Plecoptera, and Trichoptera) richness), only one of which had a low HII score. These results indicate that punctual measures of abiotic parameters do not reveal the long-term impacts of anthropic activities in these streams, including related fire management of pasture that annually alters the vegetation matrix and may act as a disturbance for the macroinvertebrate communities. Due to this, biomonitoring of low order streams in Cerrado ecosystems of the Northern Central Brazil by different biotic metrics and also physical attributes of the riparian zone

Measurement of the Ecological Integrity of Cerrado Streams Using Biological Metrics and the Index of Habitat Integrity.

PubMed

Reis, Deusiano Florêncio Dos; Salazar, Ayala Eduardo; Machado, Mayana Mendes Dias; Couceiro, Sheyla Regina Marques; Morais, Paula Benevides de

2017-01-12

Generally, aquatic communities reflect the effects of anthropogenic changes such as deforestation or organic pollution. The Cerrado stands among the most threatened ecosystems by human activities in Brazil. In order to evaluate the ecological integrity of the streams in a preserved watershed in the Northern Cerrado biome corresponding to a mosaic of ecosystems in transition to the Amazonia biome in Brazil, biological metrics related to diversity, structure, and sensitivity of aquatic macroinvertebrates were calculated. Sampling included collections along stretches of 200 m of nine streams and measurements of abiotic variables (temperature, electrical conductivity, pH, total dissolved solids, dissolved oxygen, and discharge) and the Index of Habitat Integrity (HII). The values of the abiotic variables and the HII indicated that most of the streams have good ecological integrity, due to high oxygen levels and low concentrations of dissolved solids and electric conductivity. Two streams showed altered HII scores mainly related to small dams for recreational and domestic use, use of Cerrado natural pasture for cattle raising, and spot deforestation in bathing areas. However, this finding is not reflected in the biological metrics that were used. Considering all nine streams, only two showed satisfactory ecological quality (measured by Biological Monitoring Working Party (BMWP), total richness, and EPT (Ephemeroptera, Plecoptera, and Trichoptera) richness), only one of which had a low HII score. These results indicate that punctual measures of abiotic parameters do not reveal the long-term impacts of anthropic activities in these streams, including related fire management of pasture that annually alters the vegetation matrix and may act as a disturbance for the macroinvertebrate communities. Due to this, biomonitoring of low order streams in Cerrado ecosystems of the Northern Central Brazil by different biotic metrics and also physical attributes of the riparian zone

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

PubMed Central

Cho, Judy H.; Nicolae, Dan L.; Gold, Leslee H.; Fields, Carter T.; LaBuda, Michele C.; Rohal, Patrick M.; Pickles, Michael R.; Qin, Li; Fu, Yifan; Mann, Jasdeep S.; Kirschner, Barbara S.; Jabs, Ethylin Wang; Weber, James; Hanauer, Stephen B.; Bayless, Theodore M.; Brant, Steven R.

1998-01-01

The idiopathic inflammatory bowel diseases, Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin concordance, and ethnic differences in familial risks have established that CD and UC are complex, non-Mendelian, related genetic disorders. We performed a genome-wide screen using 377 autosomal markers, on 297 CD, UC, or mixed relative pairs from 174 families, 37% Ashkenazim. We observed evidence for linkage at 3q for all families (multipoint logarithm of the odds score (MLod) = 2.29, P = 5.7 × 10−4), with greatest significance for non-Ashkenazim Caucasians (MLod = 3.39, P = 3.92 × 10−5), and at chromosome 1p (MLod = 2.65, P = 2.4 × 10−4) for all families. In a limited subset of mixed families (containing one member with CD and another with UC), evidence for linkage was observed on chromosome 4q (MLod = 2.76, P = 1.9 × 10−4), especially among Ashkenazim. There was confirmatory evidence for a CD locus, overlapping IBD1, in the pericentromeric region of chromosome 16 (MLod = 1.69, P = 2.6 × 10−3), particularly among Ashkenazim (MLod = 1.51, P = 7.8 × 10−3); however, positive MLod scores were observed over a very broad region of chromosome 16. Furthermore, evidence for epistasis between IBD1 and chromosome 1p was observed. Thirteen additional loci demonstrated nominal (MLod > 1.0, P < 0.016) evidence for linkage. This screen provides strong evidence that there are several major susceptibility loci contributing to the genetic risk for CD and UC. PMID:9636179

Analysing horizontal equity in enrolment in Disease Management Programmes for coronary heart disease in Germany 2008-2010.

PubMed

Bozorgmehr, Kayvan; San Sebastian, Miguel; Brenner, Hermann; Razum, Oliver; Maier, Werner; Saum, Kai-Uwe; Holleczek, Bernd; Miksch, Antje; Szecsenyi, Joachim

2015-03-10

Disease Management Programmes (DMPs) have been introduced in Germany ten years ago with the aim to improve effectiveness and equity of care, but little is known about the degree to which enrolment in the programme meets the principles of equity in health care. We aimed to analyse horizontal equity in DMP enrolment among patients with coronary heart disease (CHD). Cross-sectional analysis of horizontal inequities in physician-reported enrolment in the DMP for CHD in a large population-based cohort-study in Germany (2008-2010). We calculated horizontal inequity indices (HII) and their 95% confidence intervals [95%CI] for predicted need-standardised DMP enrolment across two measures of socio-economic status (SES) (educational attainment, regional deprivation) stratified by sex. Need-standardised DMP enrolment was predicted in multi-level logistic regression models. Among N = 1,280 individuals aged 55-84 years and diagnosed with CHD, DMP enrolment rates were 22.2% (women) and 35.0% (men). Education-related inequities in need-standardised DMP enrolment favoured groups with lower education, but HII estimates were not significant. Deprivation-related inequities among women significantly favoured groups with higher SES (HII = 0.086 [0.007 ; 0.165]. No such deprivation-related inequities were seen among men (HII = 0.014 [-0.048 ; 0.077]). Deprivation-related inequities across the whole population favoured groups with higher SES (HII estimates not significant). Need-standardised DMP enrolment was fairly equitable across educational levels. Deprivation-related inequities in DMP enrolment favoured women living in less deprived areas relative to those living in areas with higher deprivation. Further research is needed to gain a better understanding of the mechanisms that contribute to deprivation-related horizontal inequities in DMP enrolment among women.

ESO089-G018 and ESO089-G019: long-slit spectroscopy of emission-line galaxies

NASA Astrophysics Data System (ADS)

da Rocha-Poppe, P. C.; Faúndez-Abans, M.; Fernandes-Martin, V. A.; Fernandes, I. F.; de Oliveira-Abans, M.; Rodrígues-Ardila, A.

2010-03-01

We present the first spectroscopic observations for the galaxies ESO089-G018 (hereafter G18, an Sb(?)-type galaxy seen nearly edge-on) and ESO089-G019 (hereafter G19, an SA(s): a peculiar galaxy), extracted from the sample of ring-shaped galaxies compiled in Faúndez-Abans & de Oliveira-Abans. The main goal of this work is to investigate the spectral classification using the three line-ratio diagrams, called diagnostic diagrams, of Veilleux & Osterbrock. However, in order to separate the different types of galaxies [HII galaxies, Seyfert 2 galaxies and low-ionization nuclear emission-line region galaxies (LINERs)] we have to used empirical boundaries between them. Based on the observed spectra, we suggest G18 is a `weak-[OI] LINER' or even a `transition object' or LINER/HII. In the case of G19, we see Hβ in absorption and no [OIII] lines, impeding the [OIII]/Hβ ratio to be estimated. However, other lines ratios have been evaluated for the discussion. We classify the nature of G19 as ambiguous, because of the difficulty in determining its ionizing source (narrow-line active galactic nuclei or HII galaxies) in different diagnostic diagrams. The errors in the fluxes were mostly caused by uncertainties in the placement of the continuum level. We have estimated nuclear redshift of z = 0.034 (G18) and z = 0.039 (G19), corresponding to a heliocentric velocity of 10246 and 11734kms-1, respectively. Some other physical parameters have been derived whenever possible. All spectra were reduced and analysed in a homogeneous way with the standard IRAF procedures. Based on observations carried out at Observatório do Pico dos Dias (OPD), which operated by the LNA/MCT, Brazil-MG. E-mail: paulopoppe@gmail.com

Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities.

PubMed

Chen, Guang-Lan; Zhang, Ye; Wang, Wang-Yue; Ji, Xue-Liang; Meng, Fei; Xu, Pei-Song; Yang, Ning-Min; Ye, Fu-Qiang; Bo, Xiao-Chen

2017-07-07

To investigate alterations in the fecal microbiome using 16S rRNA amplicon sequencing in couples in the same cohabitation environment. Fecal samples were collected from eight ulcerative colitis (UC) patients and their healthy partners at Lishui People's Hospital, Zhejiang Province, China. DNA was extracted and the variable regions V3 and V4 of the 16S rRNA genes were PCR amplified using a two-step protocol. Clear reads were clustered into operational taxonomic units (OTUs) at the 97% sequence similarity level using UCLUST v1.2.22. The Wilcoxon rank-sum test (R v3.1.2) was used to compare inter-individual differences. Differences with a P value < 0.05 were considered statistically significant. Fecal microbial communities were more similar among UC patients than their healthy partners ( P = 0.024). UC individuals had a lower relative abundance of bacteria belonging to the Firmicutes , especially Blautia , Clostridium , Coprococcus and Roseburia ( P < 0.05). Microbiota dysbiosis was detected in UC patients and their healthy partners. Relevant genera included Akkermansiam , Bacteroides , Escherichia , Lactobacillales , Klebsiella and Parabacteroides . The enriched pathways in fecal samples of UC patients were related to lipid and nucleotide metabolism. Additionally, the pathways involved in membrane transport and metabolism of cofactors and vitamins were more abundant in the healthy partners. Our results suggested that the microbial composition might be affected in healthy partners cohabiting with UC patients, especially in terms of microbiota dysbiosis.

Heavy Lift Helicopter Flight Control System. Volume III. Automatic Flight Control System Development and Feasibility Demonstration

DTIC Science & Technology

1977-09-01

vdI1 SCCLRITY CLASSIFICATIOlN OF THIS PAGE(When DMae ffnifod) Block 20 (Cont): ------ AFCS control laws are examined. Associated documents are: Volume I...both the HII gain and LO gain outputs. Both were traced to defective components. In the former, the HII gain output amplifier AR4 was replaced and in...the latter, a relay in the relay module was defective . 613 S. . ......-. . . 6.2.2.4 ExcessivC Time Lag During the BARO altitude hold evaluation, the

Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.

PubMed

Uetani, Teruyoshi; Nakayama, Hironao; Okayama, Hideki; Okura, Takafumi; Higaki, Jitsuo; Inoue, Hirofumi; Higashiyama, Shigeki

2009-05-01

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a cardiogenic and cardiohypertrophic growth factor. ProHB-EGF, a product of the Hb-egf gene and the precursor of HB-EGF, is anchored to the plasma membrane. Its ectodomain region is shed by a disintegrin and metalloproteases (ADAMs) when activated by various stimulations. It has been reported that an uncleavable mutant of Hb-egf, uc-Hb-egf, produces uc-proHB-EGF, which is not cleaved by ADAMs and causes dilation of the heart in knock-in mice. This suggests that the shedding of proHB-EGF is essential for the development and survival of cardiomyocytes: however, the molecular mechanism involved has remained unclear. In this study, we investigated the relationship between uc-proHB-EGF expression and cardiomyocyte survival. Human uc-proHB-EGF was adenovirally introduced into the rat cardiomyoblast cell line H9c2, and the cells were cultured under normoxic and hypoxic conditions. Uc-proHB-EGF-expressing H9c2 cells underwent apoptosis under normoxic conditions, which distinctly increased under hypoxic conditions. Furthermore, we observed an increased Caspase-3 activity, reactive oxygen species accumulation, and an increased c-Jun N-terminal kinase (JNK) activity in the uc-proHB-EGF-expressing H9c2 cells. Treatment of the uc-proHB-EGF transfectants with inhibitors of Caspase-3, reactive oxygen species, and JNK, namely, Z-VAD-fmk, N-acetylcysteine, and SP600125, respectively, significantly reduced hypoxic cell death. These data indicate that insufficiency of proHB-EGF shedding under hypoxic stress leads to cardiomyocyte apoptosis via Caspase-3- and JNK-dependent pathways.

CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis.

PubMed

Lee, Young Ho; Kim, Jae-Hoon; Seo, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu

2014-05-01

The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms, and (AT)n repeat in the 3' untranslated region (UTR) and UC and CD susceptibility. A total of 15 comparison studies were considered in our meta-analysis. Meta-analysis revealed no association between UC and the CTLA-4 +49 G and CTLA-4 -318 T alleles in all subjects (OR=0.982, 95% CI=0.851-1.1339, p=0.804; OR=0.500, 95% CI=0.223-1.124, p=0.094). No association was found between UC and the CTLA-4 CT60 A/G polymorphism in Europeans. However, a significant association was observed between the longer allele (⩾118bp) of the (AT)n and UC in Asian population (OR=6.073, 95% CI=4.246-8.684, p=1.0×10(-9)). Meta-analysis of the CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms showed no association with CD. This meta-analysis demonstrates that the CTLA-4 (AT)n repeat in 3' UTR may be associated with susceptibility to UC in Asians, while no association was found between the CTLA-4 +49 A/G, -318 C/T, and CD60 A/G polymorphism and susceptibility to UC and CD. Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Advancing Space Sciences through Undergraduate Research Experiences at UC Berkeley's Space Sciences Laboratory - a novel approach to undergraduate internships for first generation community college students

NASA Astrophysics Data System (ADS)

Raftery, C. L.; Davis, H. B.; Peticolas, L. M.; Paglierani, R.

2015-12-01

The Space Sciences Laboratory at UC Berkeley launched an NSF-funded Research Experience for Undergraduates (REU) program in the summer of 2015. The "Advancing Space Sciences through Undergraduate Research Experiences" (ASSURE) program recruited heavily from local community colleges and universities, and provided a multi-tiered mentorship program for students in the fields of space science and engineering. The program was focussed on providing a supportive environment for 2nd and 3rd year undergraduates, many of whom were first generation and underrepresented students. This model provides three levels of mentorship support for the participating interns: 1) the primary research advisor provides academic and professional support. 2) The program coordinator, who meets with the interns multiple times per week, provides personal support and helps the interns to assimilate into the highly competitive environment of the research laboratory. 3) Returning undergraduate interns provided peer support and guidance to the new cohort of students. The impacts of this program on the first generation students and the research mentors, as well as the lessons learned will be discussed.

UC Irvine CHRS Real-time Global Satellite Precipitation Monitoring System (G-WADI PERSIANN-CCS GeoServer) for Hydrometeorological Applications

NASA Astrophysics Data System (ADS)

Sorooshian, S.; Hsu, K. L.; Gao, X.; Imam, B.; Nguyen, P.; Braithwaite, D.; Logan, W. S.; Mishra, A.

2015-12-01

The G-WADI Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Cloud Classification System (PERSIANN-CCS) GeoServer has been successfully developed by the Center for Hydrometeorology and Remote Sensing (CHRS) at the University of California Irvine in collaboration with the UNESCO's International Hydrological Programme (IHP) and a number of its international centers. The system employs state-of-the-art technologies in remote sensing and artificial intelligence to estimate precipitation globally from satellite imagery in real-time and high spatiotemporal resolution (4km, hourly). It offers graphical tools and data service to help the user in emergency planning and management for natural disasters related to hydrological processes. The G-WADI PERSIANN-CCS GeoServer has been upgraded with new user-friendly functionalities. The precipitation data generated by the GeoServer is disseminated to the user community through support provided by ICIWaRM (The International Center for Integrated Water Resources Management), UNESCO and UC Irvine. Recently a number of new applications for mobile devices have been developed by our students. The RainMapper has been available on App Store and Google Play for the real-time PERSIANN-CCS observations. A global crowd sourced rainfall reporting system named iRain has also been developed to engage the public globally to provide qualitative information about real-time precipitation in their location which will be useful in improving the quality of the PERSIANN-CCS data. A number of recent examples of the application and use of the G-WADI PERSIANN-CCS GeoServer information will also be presented.

Model nebulae and determination of the chemical composition of the Magellanic Clouds

PubMed Central

Aller, L. H.; Keyes, C. D.; Czyzak, S. J.

1979-01-01

An analysis of previously presented photoelectric spectrophotometry of HII regions (emission-line diffuse nebulae) in the two Magellanic Clouds is carried out with the aid of theoretical nebular models, which are used primarily as interpolation devices. Some advantages and limitations of such theoretical models are discussed. A comparison of the finally obtained chemical compositions with those found by other observers shows generally a good agreement, suggesting that it is possible to obtain reliable chemical compositions from low excitation gaseous nebulae in our own galaxy as well as in distant stellar systems. PMID:16592633

X-ray diving in the center of Sh2-129: looking for the driving source of Ou4

NASA Astrophysics Data System (ADS)

Grosso, Nicolas

2012-10-01

The outflow phenomenon is associated both with the early and the last phase of the stellar evolution. Recently, a unique bipolar outflow with an angular size of 1.2 degrees was discovered in the blister HII region Sh2-129. Ou4, nicknamed "The Giant Squid", is to our knowledge the bipolar outflow with the largest angular size ever found. We propose joint XMM-Newton/EPIC (35 ks) and Chandra/HRC-I (16 ks) observations to look for the driving source of Ou4 and to clarify the nature of this object.

Measuring star formation rates in blue galaxies

NASA Technical Reports Server (NTRS)

Gallagher, John S., III; Hunter, Deidre A.

1987-01-01

The problems associated with measurements of star formation rates in galaxies are briefly reviewed, and specific models are presented for determinations of current star formation rates from H alpha and Far Infrared (FIR) luminosities. The models are applied to a sample of optically blue irregular galaxies, and the results are discussed in terms of star forming histories. It appears likely that typical irregular galaxies are forming stars at nearly constant rates, although a few examples of systems with enhanced star forming activity are found among HII regions and luminous irregular galaxies.

Isolated Star-Forming Cloud Discovered in Intracluster Space

NASA Astrophysics Data System (ADS)

2003-01-01

Subaru and VLT Join Forces in New Study of Virgo Galaxy Cluster [1] Summary At a distance of some 50 million light-years, the Virgo Cluster is the nearest galaxy cluster. It is located in the zodiacal constellation of the same name (The Virgin) and is a large and dense assembly of hundreds of galaxies. The "intracluster" space between the Virgo galaxies is permeated by hot X-ray emitting gas and, as has become clear recently, by a sparse "intracluster population of stars". So far, stars have been observed to form in the luminous parts of galaxies. The most massive young stars are often visible indirectly by the strong emission from surrounding cocoons of hot gas, which is heated by the intense radiation from the embedded stars. These "HII regions" (pronounced "Eitch-Two" and so named because of their content of ionized hydrogen) may be very bright and they often trace the beautiful spiral arms seen in disk galaxies like our own Milky Way. New observations by the Japanese 8-m Subaru telescope and the ESO Very Large Telescope (VLT) have now shown that massive stars can also form in isolation, far from the luminous parts of galaxies. During a most productive co-operation between astronomers working at these two world-class telescopes, a compact HII region has been discovered at the very boundary between the outer halo of a Virgo cluster galaxy and Virgo intracluster space. This cloud is illuminated and heated by a few hot and massive young stars. The estimated total mass of the stars in the cloud is only a few hundred times that of the Sun. Such an object is rare at the present epoch. However, there may have been more in the past, at which time they were perhaps responsible for the formation of a fraction of the intracluster stellar population in clusters of galaxies. Massive stars in such isolated HII regions will explode as supernovae at the end of their short lives, and enrich the intracluster medium with heavy elements. Observations of two other Virgo cluster

The American Indian Summer Institute in Earth System Science (AISESS) at UC Irvine: A Two-Week Residential Summer Program for High School Students

NASA Astrophysics Data System (ADS)

Johnson, K. R.; Polequaptewa, N.; Leon, Y.

2012-12-01

Native Americans remain severely underrepresented in the geosciences, despite a clear need for qualified geoscience professionals within Tribal communities to address critical issues such as natural resource and land management, water and air pollution, and climate change. In addition to the need for geoscience professionals within Tribal communities, increased participation of Native Americans in the geosciences would enhance the overall diversity of perspectives represented within the Earth science community and lead to improved Earth science literacy within Native communities. To address this need, the Department of Earth System Science and the American Indian Resource Program at the University California have organized a two-week residential American Indian Summer Institute in Earth System Science (AISESS) for high-school students (grades 9-12) from throughout the nation. The format of the AISESS program is based on the highly-successful framework of a previous NSF Funded American Indian Summer Institute in Computer Science (AISICS) at UC Irvine and involves key senior personnel from the AISICS program. The AISESS program, however, incorporates a week of camping on the La Jolla Band of Luiseño Indians reservation in Northern San Diego County, California. Following the week of camping and field projects, the students spend a week on the campus of UC Irvine participating in Earth System Science lectures, laboratory activities, and tours. The science curriculum is closely woven together with cultural activities, native studies, and communication skills programs The program culminates with a closing ceremony during which students present poster projects on environmental issues relevant to their tribal communities. The inaugural AISESS program took place from July 15th-28th, 2012. We received over 100 applications from Native American high school students from across the nation. We accepted 40 students for the first year, of which 34 attended the program. The

THE NASA-UC ETA-EARTH PROGRAM. II. A PLANET ORBITING HD 156668 WITH A MINIMUM MASS OF FOUR EARTH MASSES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howard, Andrew W.; Marcy, Geoffrey W.; Isaacson, Howard

2011-01-10

We report the discovery of HD 156668 b, an extrasolar planet with a minimum mass of M{sub P} sin i = 4.15 M{sub +}. This planet was discovered through Keplerian modeling of precise radial velocities from Keck-HIRES and is the second super-Earth to emerge from the NASA-UC Eta-Earth Survey. The best-fit orbit is consistent with circular and has a period of P = 4.6455 days. The Doppler semi-amplitude of this planet, K = 1.89 m s{sup -1}, is among the lowest ever detected, on par with the detection of GJ 581 e using HARPS. A longer period (P {approx} 2.3more » years), low-amplitude signal of unknown origin was also detected in the radial velocities and was filtered out of the data while fitting the short-period planet. Additional data are required to determine if the long-period signal is due to a second planet, stellar activity, or another source. Photometric observations using the Automated Photometric Telescopes at Fairborn Observatory show that HD 156668 (an old, quiet K3 dwarf) is photometrically constant over the radial velocity period to 0.1 mmag, supporting the existence of the planet. No transits were detected down to a photometric limit of {approx}3 mmag, ruling out transiting planets dominated by extremely bloated atmospheres, but not precluding a transiting solid/liquid planet with a modest atmosphere.« less

The galactic gamma-ray distribution: Implications for galactic structure and the radial cosmic ray gradient

NASA Technical Reports Server (NTRS)

Harding, A. K.; Stecker, F. W.

1984-01-01

The radial distribution of gamma ray emissivity in the Galaxy was derived from flux longitude profiles, using both the final SAS-2 results and the recently corrected COS-B results and analyzing the northern and southern galactic regions separately. The recent CO surveys of the Southern Hemisphere, were used in conjunction with the Northern Hemisphere data, to derive the radial distribution of cosmic rays on both sides of the galactic plane. In addition to the 5 kpc ring, there is evidence from the radial asymmetry for spiral features which are consistent with those derived from the distribution of bright HII regions. Positive evidence was also found for a strong increase in the cosmic ray flux in the inner Galaxy, particularly in the 5 kpc region in both halves of the plane.

Current status of the CALET mission

NASA Astrophysics Data System (ADS)

Mori, Masaki

2017-01-01

The CALorimeteric Electron Telescope (CALET) is a Japanese-led international mission being developed as part of the utilization plan for the International Space Station (ISS). CALET was launched by an H-II B rocket utilizing the Japanese developed HTV (H-II Transfer Vehicle) in August 2015, and has been measuring high-energy electrons, cosmic rays as well as gamma rays above 10 GeV to about 10 TeV with high accuracy. In this paper we describe the current status of the CALET mission focused on gamma-ray observations.

5-ASA in ulcerative colitis: improving treatment compliance.

PubMed

Prantera, Cosimo; Rizzi, Marina

2009-09-21

5-Aminosalicylic acid (5-ASA) compounds are a highly effective treatment for ulcerative colitis (UC). While UC patient compliance in clinical studies is over 90%, only 40% of patients in every day life take their prescribed therapy. Adherence to medication has been emphasized recently by a Cochrane meta-analysis that has suggested that future trials of 5-ASA in UC should look at patient compliance rather than drug efficacy. Better compliance can be obtained by reducing the number of tablets and times of administration. Given that the 5-ASA formulations have different delivery systems that split the active moiety in various regions of the intestine, it is particularly important that an adequate dose of the drug arrives at the inflamed part of the colon. 5-ASA Multi matrix (MMx) is a novel, high strength (1.2 g), oral formulation designed for once-daily dosing. It releases the active moiety throughout the colon. Different studies with this compound have shown that it is as effective as 5-ASA enema in the treatment of mild-to-moderate, left-sided UC, and is comparable to a pH-dependent, delayed release 5-ASA (Asacol), even if given once daily. Recently, the effectiveness in the acute phase of UC has been confirmed also in maintenance. In conclusion, at present, 5-ASA MMx seems theoretically the best agent for maintaining patient compliance, and consequently, treatment effectiveness.

OT2_pgolds01_6: Herschel [NII] Observations to Define the Source of [CII] Emission

NASA Astrophysics Data System (ADS)

Goldsmith, P.

2011-09-01

The 158 micron line of ionized carbon is the strongest single long-wavelength emission feature from the interstellar medium and is the most important coolant of gas in which hydrogen is in atomic form. It is a key determinant of the evolution of these largely atomic regions into denser, cooler molecular clouds in which new stars are formed, and is widely used as a tracer of star formation in the Milky Way and other galaxies. There is, however, an ongoing, serious controversy about the origin of the [CII] emission, which has been asserted to come from the extended low-density warm interstellar medium, but has more generally been associated with the primarily molecular photon dominated regions (PDRs) intimately associated with massive, young stars. We propose a combined HIFI and PACS study of the two far-infrared [NII] fine structure lines in order to resolve the important question of the fraction of CII emission that arises in ionized gas. Specifically, we will (1) utilize the fact that due to its ionization potential NII is found only in HII regions, and with PACS 122 and 205 micron observations, determine electron densities in a sample of such regions in the Galactic plane; (2) utilize available data on radio free-free and H-alpha emission to determine the NII column densities and from this the CII column densities in the HII regions; (3) use the electron densities to determine the fraction of CII emission arising in the ionized interstellar medium. These observations will be carried out at 150 of the positions in the Galactic plane observed in [CII] by the GOT-C+ project. We will also carry out HIFI observations of 10 selected positions in the 205 micron line to determine spectral characteristics of the NII emission line, which with CII, CI, and CO profiles already in hand will serve as a further discriminant among the proposed sources of CII emission.

The influence of phase transitions in phosphatidylethanolamine models on the activity of violaxanthin de-epoxidase.

PubMed

Vieler, Astrid; Scheidt, Holger A; Schmidt, Peter; Montag, Cindy; Nowoisky, Janine F; Lohr, Martin; Wilhelm, Christian; Huster, Daniel; Goss, Reimund

2008-04-01

In the present study, the influence of the phospholipid phase state on the activity of the xanthophyll cycle enzyme violaxanthin de-epoxidase (VDE) was analyzed using different phosphatidylethanolamine species as model lipids. By using (31)P NMR spectroscopy, differential scanning calorimetry and temperature dependent enzyme assays, VDE activity could directly be related to the lipid structures the protein is associated with. Our results show that the gel (L beta) to liquid-crystalline (L alpha) phase transition in these single lipid component systems strongly enhances both the solubilization of the xanthophyll cycle pigment violaxanthin in the membrane and the activity of the VDE. This phase transition has a significantly stronger impact on VDE activity than the transition from the L alpha to the inverted hexagonal (HII) phase. Especially at higher temperatures we found increased VDE reaction rates in the presence of the L alpha phase compared to those in the presence of HII phase forming lipids. Our data furthermore imply that the HII phase is better suited to maintain high VDE activities at lower temperatures.

Near infrared observations of S155. evidence of induced star formation?

NASA Astrophysics Data System (ADS)

Hunt, L. K.; Lisi, F.; Felli, M.; Tofani, G.

At the interface of the giant molecular cloud Cepheus OB3, S155 represents one of the most interesting examples of bright rim produced by the ionization of a nearby O-star. The interaction between the ionized HII region S155 and the hot molecular core Cepheus B may constitute the ideal site for new stars, according to the sequential star-formation theory. Past observations of molecular lines have shown the evidence of a hot spot in the cloud core, probably a compact region associated to a young stellar object. New J,H,K images recently obtained with the ARNICA array at the TIRGO telescope give evidence of stars with strong near-infrared excess, which must represent the newest generation of young stars.

Probing the End of the IMF in NGC 2024 with NIRCam on JWST: Assessing the Impact of Nebular Emission in Galactic Star Forming Regions

NASA Astrophysics Data System (ADS)

Suri, Veenu; Meyer, Michael; Greenbaum, Alexandra Z.; Bell, Cameron; Beichman, Charles; Gordon, Karl D.; Greene, Thomas P.; Hodapp, K.; Horner, Scott; Johnstone, Doug; Leisenring, Jarron; Manara, Carlos; Mann, Rita; Misselt, K.; Raileanu, Roberta; Rieke, Marcia; Roellig, Thomas

2018-01-01

We describe observations of the embedded young cluster associated with the HII region NGC 2024 planned as part of the guaranteed time observing program for the James Webb Space Telescope with the NIRCam (Near Infrared Camera) instrument. Our goal is to obtain a census of the cluster down to 2 Jupiter masses, viewed through 10-20 magnitudes of extinction, using multi-band filter photometry, both broadband filters and intermediate band filters that are expected to be sensitive to temperature and surface gravity. The cluster contains several bright point sources as well as extended emission due to reflected light, thermal emission from warm dust, as well as nebular line emission. We first developed techniques to better understand which point sources would saturate in our target fields when viewed through several JWST NIRCam filters. Using images of the field with the WISE satellite in filters W1 and W2, as well as 2MASS (J and H) bands, we devised an algorithm that takes the K-band magnitudes of point sources in the field, and the known saturation limits of several NIRCam filters to estimate the impact of the extended emission on survey sensitivity. We provide an overview of our anticipated results, detecting the low mass end of the IMF as well as planetary mass objects likely liberated through dynamical interactions.

p53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis.

PubMed

Lu, Xiaohong; Yu, Yuanjie; Tan, Shiyun

2017-10-25

Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC. Publications were searched in the PubMed, Embase, EBSCO, Wangfang, and CNKI databases. The overall odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were summarized in this study. Final 19 papers were identified in this meta-analysis, including 1068 patients with UC and 130 normal tissue samples. Immunohistochemical p53 expression was significantly higher in UC without dysplasia and carcinoma (UC group) compared to normal tissue samples (OR = 3.14, P = 0.001), higher in UC with dysplasia than in UC group (OR = 10.76, P < 0.001), and higher in UC with colorectal cancer (CRC) than in UC with dysplasia (OR = 1.69, P = 0.035). Subgroup analysis of ethnicity (UC group vs. normal tissues) showed that p53 expression was correlated with UC in Asians, but not in Caucasians. When UC with dysplasia was compared to UC group, p53 expression was linked to UC with dysplasia among both Asians and Caucasians. When UC-CRC was compared to UC with dysplasia, p53 expression was not associated with UC-CRC in both Caucasians and Asians. p53 expression was closely associated with UC-CRC development. p53 expression showed different ethnic characteristics among different pathological types of UC.

Revealing the Galactic Center in the Far-Infrared with SOFIA/FORCAST

NASA Astrophysics Data System (ADS)

Lau, Ryan M.; Herter, Terry; Morris, Mark; Li, Zhiyuan; Becklin, Eric; Adams, Joseph; Hankins, Matthew

2015-08-01

We present a summary of far-infrared imaging observations of the inner 40 pc of the Galactic center addressing the dense, dusty torus around Sgr A*, massive star formation, and dust production around massive stars and in the Sgr A East supernova remnant. Observations of warm dust emission were performed using the Faint Object Infrared Camera for the SOFIA Telescope (FORCAST). The Circumnuclear Ring (CNR) surrounding and heated by central cluster in the vicinity of Sgr A* shows no internal active star formation but does exhibit significant density “clumps,” a surprising result because tidal shearing should act quickly to smear out structure. G-0.02-0.07, a complex consisting of three compact HII regions and one ultracompact HII region, is site of the most recent confirmed star formation within ~10 pc of the Galactic center. Our observations reveal the dust morphologies and SEDs of the regions to constrain the composition and gas-to-dust mass ratios of the emitting dust and identify heating sources candidates from archival near-IR images. FORCAST observations Luminous Blue Variables (LBVs) located in and near the Quintuplet Cluster reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding G0.120-0.048. These two LBV’s have nebulae with similar quantities of dust (~0.02 M⊙) but exhibit contrasting appearances due to the external influence of their different environments. Finally, the far-infrared observations indicate the presence of ~0.02 M⊙ of warm (~100 K) dust in the hot interior of the ~10,000 yr-old SgrA East supernova remnant indicating the dust has survived the passage of the reverse shock. The results suggest that supernovae may indeed be the dominant dust production mechanism in the dense environment of early Universe galaxies.

Direct Measurement of Dust Attenuation in z approx. 1.5 Star-Forming Galaxies from 3D-HST: Implications for Dust Geometry and Star Formation Rates

NASA Technical Reports Server (NTRS)

Price, Sedona H.; Kriek, Mariska; Brammer, Gabriel B; Conroy, Charlie; Schreiber, Natascha M. Foerster; Franx, Marijn; Fumagalli, Mattia; Lundren, Britt; Momcheva, Ivelina; Nelson, Erica J.;

[Crohns disease and ulcerative colitis - current view on genetic determination, immunopathogenesis and biologic therapy].

PubMed

Buc, M

2017-01-01

Crohns disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the intestine, also called inflammatory bowel diseases (IBD), which are not caused by pathogenic microorganisms but result from non-specific inflammatory processes in the bowel. IBD are polygenic diseases, as evidenced by the genome-wide association studies (GWAS), which have discovered more than 200 genes or genetic regions to be associated with IBD. Some of them are specific for CD or UC; however, there are 110 overlapping genes. In the pathogenesis of CD, activation of adaptive immunity mediated by TH1, TH17, or TH1/TH17 cells is induced because of disturbances in the mechanisms of innate immunity and autophagocytosis. By comparison, the major events that trigger autoimmune processes in UC are an increased translocation of commensal bacteria into the submucosa because of loose inter-epithelial connections with subsequent activation of ILC2, TH9, TH2, and NKT cells. Knowledge of the pathogenesis of a disease enables an effective therapy, which is especially true for biological therapy. It is noteworthy that monoclonal antibodies directed against the major protagonists underlying both CD and UC have failed. It points to the complexity of immunopathologic processes that run in both diseases. One can suppose that a blockade of one inflammatory pathway is circumvented by an alternative pathway. TNF is the principal pro-inflammatory cytokine that plays a major role in CD and UC as well. It was therefore decided to treat IBD patients with anti-TNF monoclonal antibodies, infliximab or adalimumab. Approximately one half of the CD patients and one third of the UC patients respond to this treatment.

Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea, 2011-2014: A Nationwide Population-Based Study.

PubMed

Jung, Yoon Suk; Han, Minkyung; Kim, Won Ho; Park, Sohee; Cheon, Jae Hee

2017-08-01

The incidence of inflammatory bowel disease (IBD) is increasing in East Asia; however, population-based data from this region are lacking. We conducted a nationwide, population-based study to examine the incidence and disease course of IBD in South Korea. Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD [10,049 with ulcerative colitis (UC) and 5595 with Crohn's disease (CD)] from 2011 to 2014. During the study period, the average annual incidence of UC was 5.0 per 10 5 , while that of CD was 2.8 per 10 5 . Among patients with UC, the cumulative rates of surgery 1 and 4 years after diagnosis were 1.0 and 2.0%; those among patients with CD were 9.0 and 13.9%, respectively. The 1- and 4-year cumulative rates of moderate- to high-dose corticosteroid use were, respectively, 26.6 and 45.2% among patients with UC, and 29.9 and 50.8% among those with CD. Similarly, the 1- and 4-year cumulative rates of immunomodulator use were 14.1 and 26.4% among patients with UC, and 58.3 and 76.1% among those with CD, respectively. With regard to biologic use, the 1- and 4-year cumulative rates were 3.0 and 9.0% among patients with UC, and 11.1 and 31.7% among those with CD, respectively. The recent incidence of IBD in South Korea has been the highest in East Asia. Patients who had been diagnosed recently with IBD showed lower rates of surgery and higher rates of immunomodulator and biologic use compared to those reported ever in South Korea.

Ulcerative colitis in northern Portugal and Galicia in Spain.

PubMed

Barreiro-de Acosta, Manuel; Magro, Fernando; Carpio, Daniel; Lago, Paula; Echarri, Ana; Cotter, José; Pereira, Santos; Gonçalves, Raquel; Lorenzo, Aurelio; Carvalho, Laura; Castro, Javier; Barros, Luisa; Dias, Jorge Amil; Rodrigues, Susana; Portela, Francisco; Dias, Camila; da Costa-Pereira, Altamiro

2010-07-01

Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.

The use of a proteinaceous "cushion" with a polystyrene-binding peptide tag to control the orientation and function of a target peptide adsorbed to a hydrophilic polystyrene surface.

PubMed

Imanaka, Hiroyuki; Yamadzumi, Daisuke; Yanagita, Keisuke; Ishida, Naoyuki; Nakanishi, Kazuhiro; Imamura, Koreyoshi

2016-03-01

In immobilizing target biomolecules on a solid surface, it is essential (i) to orient the target moiety in a preferred direction and (ii) to avoid unwanted interactions of the target moiety including with the solid surface. The preferred orientation of the target moiety can be achieved by genetic conjugation of an affinity peptide tag specific to the immobilization surface. Herein, we report on a strategy for reducing the extent of direct interaction between the target moiety and surface in the immobilization of hexahistidine peptide (6His) and green fluorescent protein (GFP) on a hydrophilic polystyrene (PS) surface: Ribonuclease HII from Thermococcus kodakaraensis (cHII) was genetically inserted as a "cushion" between the PS-affinity peptide tag and target moiety. The insertion of a cushion protein resulted in a considerably stronger immobilization of target biomolecules compared to conjugation with only a PS affinity peptide tag, resulting in a substantially enhanced accessibility of the detection antibody to the target 6His peptide. The fluorescent intensity of the GFP moiety was decreased by approximately 30% as the result of fusion with cHII and the PS-affinity peptide tag but was fully retained in the immobilization on the PS surface irrespective of the increased binding force. Furthermore, the fusion of cHII did not impair the stability of the target GFP moiety. Accordingly, the use of a proteinaceous cushion appears to be promising for the immobilization of functional biomolecules on a solid surface. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:527-534, 2016. © 2016 American Institute of Chemical Engineers.

Effects of the combination of wheel running and atomoxetine on cue- and cocaine-primed reinstatement in rats selected for high or low impulsivity.

PubMed

Zlebnik, Natalie E; Carroll, Marilyn E

2015-03-01

Aerobic exercise and the attention-deficit/hyperactivity disorder medication, atomoxetine (ATO), are two monotherapies that have been shown to suppress reinstatement of cocaine-seeking in an animal model of relapse. The present study investigated the effects of combining wheel running and ATO versus each treatment alone on cocaine-seeking precipitated by cocaine and cocaine-paired cues in rats with differing susceptibility to drug abuse (i.e., high vs. low impulsive). Rats were screened for high (HiI) or low impulsivity (LoI) based on their performance on a delay-discounting task and then trained to self-administer cocaine (0.4 mg/kg/inf) for 10 days. Following 14 days of extinction, both groups were tested for reinstatement of cocaine-seeking precipitated by cocaine or cocaine-paired cues in the presence of concurrent running wheel access (W), pretreatment with ATO, or both (W+ATO). HiI rats acquired cocaine self-administration more quickly than LoI rats. While both individual treatments and W+ATO significantly attenuated cue-induced cocaine seeking in HiI and LoI rats, only W+ATO was effective in reducing cocaine-induced reinstatement compared with vehicle treatment. There were dose-dependent and phenotype-specific effects of ATO with HiI rats responsive to the low but not high ATO dose. Floor effects of ATO and W on cue-induced reinstatement prevented the assessment of combined treatment effects. These findings demonstrated greater attenuation of cue- versus cocaine-induced reinstatement by ATO and W alone and recapitulate impulsivity phenotype differences in both acquisition of cocaine self-administration and receptivity to treatment.

Disentangling the gamma-ray emission towards Cygnus X: Sh2-104

NASA Astrophysics Data System (ADS)

Gotthelf, Eric

2015-09-01

We have just discovered distinct X-ray emission coincident with VER J2018+363, a TeV source recently resolved from the giant gamma-ray complex MGRO J2019+37 in the Cygnus region. NuSTAR reveals a hard point source and a diffuse nebula adjacent to and possibly part of Sh2-104, a compact HII region containing several young massive stellar clusters. There is reasonable evidence that these X-rays probe the origin of the gamma-ray flux, however, unrelated extragalactic sources need to be excluded. We propose a short Chandra observation to localize the X-ray emission to identify a putative pulsar or stellar counterpart(s). This is an important step to fully understand the energetics of the MGRO J2019+37 complex and the production of gamma-rays in star formation regions, in general.

Japan's launch vehicle program update

NASA Astrophysics Data System (ADS)

Tadakawa, Tsuguo

1987-06-01

NASDA is actively engaged in the development of H-I and H-II launch vehicle performance capabilities in anticipation of future mission requirements. The H-I has both two-stage and three-stage versions for medium-altitude and geosynchronous orbits, respectively; the restart capability of the second stage affords considerable mission planning flexibility. The H-II vehicle is a two-stage liquid rocket primary propulsion design employing two solid rocket boosters for secondary power; it is capable of launching two-ton satellites into geosynchronous orbit, and reduces manufacture and launch costs by extensively employing off-the-shelf technology.

Yields of damage to C4' deoxyribose and to pyrimidines in pUC18 by the direct effect of ionizing radiation.

PubMed

Peoples, Anita R; Lee, Jane; Weinfeld, Michael; Milligan, Jamie R; Bernhard, William A

2012-07-01

Our mechanistic understanding of damage formation in DNA by the direct effect relies heavily on what is known of free radical intermediates studied by EPR spectroscopy. Bridging this information to stable product formation requires methods with comparable sensitivities, a criterion met by the (32)P-post-labeling assay developed by Weinfeld and Soderlind, [Weinfeld,M. and Soderlind,K.-J.M. (1991) (32)P-Postlabeling detection of radiation-induced DNA damage: identification and estimation of thymine glycols and phosphoglycolate termini. Biochemistry, 30, 1091-1097] which when applied to the indirect effect, detected phosphoglycolate (pg) and thymine glycol (Tg). Here we applied this assay to the direct effect, measuring product yields in pUC18 films with hydration levels (Γ) of 2.5, 16 or 23 waters per nucleotide and X-irradiated at either 4 K or room temperature (RT). The yields of pg [G(pg)] for Γ ≈ 2.5 were 2.8 ± 0.2 nmol/J (RT) and 0.2 ± 0.3 nmol/J (4 K), which is evidence that the C4' radical contributes little to the total deoxyribose damage via the direct effect. The yield of detectable base damage [G(B*)] at Γ ≈ 2.5 was found to be 30.2 ± 1.0 nmol/J (RT) and 12.9 ± 0.7 nmol/J (4 K). While the base damage called B*, could be due to either oxidation or reduction, we argue that two reduction products, 5,6-dihydrouracil and 5,6-dihydrothymine, are the most likely candidates.

Structural and optical investigation in Er3+ doped Y2MoO6 phosphors

NASA Astrophysics Data System (ADS)

Mondal, Manisha; Rai, Vineet Kumar

2018-05-01

The Er3+ doped Y2MoO6 phosphors have been structurally and optically characterized by X-ray Diffraction (XRD), Field emission scanning electron microscopy (FESEM), UV-Vis absorption spectroscopy and frequency upconversion (UC) emission studies. The crystal and the particles size are found to be ˜ 85 nm and ˜ 200 nm from XRD and FESEM analysis. The intense peak at ˜ 206 nm in the UV-Vis absorption spectroscopy is attributed due to the charge transfer transition between the Mo6+ and the O2- ions in the MoO4 group in the host molybdate. The frequency UC emission studies of the prepared phosphors under 980 nm diode laser excitation shows the intense UC emission in the 0.3 mol% concentrations for the Er3+ ions. In the UC emission spectra, the emission peaks at green (˜ 525 nm and ˜ 546 nm) and red (˜ 656 nm) bands are corresponding to the 2H11/2, 4S3/2 → 4I15/2 and 4F9/2 → 4I15/2 transitions of Er3+ ions. The mechanisms involved in the UC process have been explored with the help of energy level diagram. Moreover, the CIE point (0.31, 0.60) lie in the green colour region which indicates that the developed phosphor have suitable applications in NIR to visible upconverter and in making green light display devices.

Up-conversion white light of Tm 3+/Er 3+/Yb 3+ tri-doped CaF 2 phosphors

NASA Astrophysics Data System (ADS)

Cao, Chunyan; Qin, Weiping; Zhang, Jisen; Wang, Yan; Wang, Guofeng; Wei, Guodong; Zhu, Peifen; Wang, Lili; Jin, Longzhen

2008-03-01

Tm3+/Er3+/Yb3+ tri-doped CaF2 phosphors were synthesized using a hydrothermal method. The phosphors were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and up-conversion (UC) emission spectra. After annealing, the phosphors emitted white light under a 980 nm continuous wave diode laser (CW LD 2 W) excitation. As the excitation power density changed in the range of 20-260 W/cm2, the chromaticity coordinates of the UC light of the phosphor Ca0.885Tm0.005Er0.01Yb0.1F2 fell well in the white region of the 1931 CIE diagram. For the proportion of red, green and blue (RGB) in white light is strict, key factors for achieving UC white light, such as host materials, rare earth ions doping concentrations, annealing temperatures, as well as the excitation power densities, were investigated and discussed.

Regional Distribution of Longevity Population and Elements in Drinking Water in Jiangjin District, Chongqing City, China.

PubMed

Liu, Yonglin; Yuan, Yuyang; Luo, Kunli

2017-10-25

In order to determine the spatial variation of longevity population and elements contained in the drinking water of longevity region in Jiangjin and investigate the relationship between the elements in drinking water and longevity, population censuses on township level and 98 drinking water samples from Jiangjin District, Chongqing City in West China were collected and analyzed. Population statistics on township level showed that the number of centenarians per 100,000 inhabitants (OC), centenarity index (CI), and number of centenarians per 10,000 over 65-year-old subjects (UC) present obvious geographic distribution properties, generally Central region > Northern region > Southern region (Kruskal-Wallis test, p < 0.05). Moderate hard water (150 mg/L < total hardness (TH) = 156.17 mg/L < 300 mg/L) was mainly found in drinking water from longevity township (OC > 7.5) in Jiangjin District, whereas soft water (75 mg/L < TH = 111.23 mg/L < 150 mg/L) was mostly in non-longevity township (OC < 7.5). The mean concentration of strontium (Sr) (0.73 mg/L) in drinking water from the longevity township was apparently higher than that of non-longevity township (0.44 mg/L) (Mann-Whitney U test, p = 0.019 < 0.05). The concentrations of Ba, Li, Mn, Ni, and Se in drinking water from longevity township were also higher than those of non-longevity township (Mann-Whitney U test, p < 0.05). The research indicates that exercising strict control over the concentrations of TH, Sr, Ba, Li, Mn, Ni, and Se in drinking water might be good for the health and prolong people's life.

Loss of Sh3gl2/Endophilin A1 Is a Common Event in Urothelial Carcinoma that Promotes Malignant Behavior12

PubMed Central

Majumdar, Shyama; Gong, Edward M; Di Vizio, Dolores; Dreyfuss, Jonathan; DeGraff, David J; Hager, Martin H; Park, Peter J; Bellmunt, Joaquim; Matusik, Robert J; Rosenberg, Jonathan E; Adam, Rosalyn M

2013-01-01

Urothelial carcinoma (UC) causes substantial morbidity and mortality worldwide. However, the molecular mechanisms underlying urothelial cancer development and tumor progression are still largely unknown. Using informatics analysis, we identified Sh3gl2 (endophilin A1) as a bladder urothelium-enriched transcript. The gene encoding Sh3gl2 is located on chromosome 9p, a region frequently altered in UC. Sh3gl2 is known to regulate endocytosis of receptor tyrosine kinases implicated in oncogenesis, such as the epidermal growth factor receptor (EGFR) and c-Met. However, its role in UC pathogenesis is unknown. Informatics analysis of expression profiles as well as immunohistochemical staining of tissue microarrays revealed Sh3gl2 expression to be decreased in UC specimens compared to nontumor tissues. Loss of Sh3gl2 was associated with increasing tumor grade and with muscle invasion, which is a reliable predictor of metastatic disease and cancer-derived mortality. Sh3gl2 expression was undetectable in 19 of 20 human UC cell lines but preserved in the low-grade cell line RT4. Stable silencing of Sh3gl2 in RT4 cells by RNA interference 1) enhanced proliferation and colony formation in vitro, 2) inhibited EGF-induced EGFR internalization and increased EGFR activation, 3) stimulated phosphorylation of Src family kinases and STAT3, and 4) promoted growth of RT4 xenografts in subrenal capsule tissue recombination experiments. Conversely, forced re-expression of Sh3gl2 in T24 cells and silenced RT4 clones attenuated oncogenic behaviors, including growth and migration. Together, these findings identify loss of Sh3gl2 as a frequent event in UC development that promotes disease progression. PMID:23814487

The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis.

PubMed

Smolinska, A; Bodelier, A G L; Dallinga, J W; Masclee, A A M; Jonkers, D M; van Schooten, F-J; Pierik, M J

2017-05-01

To optimise treatment of ulcerative colitis (UC), patients need repeated assessment of mucosal inflammation. Current non-invasive biomarkers and clinical activity indices do not accurately reflect disease activity in all patients and cannot discriminate UC from non-UC colitis. Volatile organic compounds (VOCs) in exhaled air could be predictive of active disease or remission in Crohn's disease. To investigate whether VOCs are able to differentiate between active UC, UC in remission and non-UC colitis. UC patients participated in a 1-year study. Clinical activity index, blood, faecal and breath samples were collected at each out-patient visit. Patients with clear defined active faecal calprotectin >250 μg/g and inactive disease (Simple Clinical Colitis Activity Index <3, C-reactive protein <5 mg/L and faecal calprotectin <100 μg/g) were included for cross-sectional analysis. Non-UC colitis was confirmed by stool culture or radiological evaluation. Breath samples were analysed by gas chromatography time-of-flight mass spectrometry and kernel-based method to identify discriminating VOCs. In total, 72 UC (132 breath samples; 62 active; 70 remission) and 22 non-UC-colitis patients (22 samples) were included. Eleven VOCs predicted active vs. inactive UC in an independent internal validation set with 92% sensitivity and 77% specificity (AUC 0.94). Non-UC colitis patients could be clearly separated from active and inactive UC patients with principal component analysis. Volatile organic compounds can accurately distinguish active disease from remission in UC and profiles in UC are clearly different from profiles in non-UC colitis patients. VOCs have demonstrated potential as new non-invasive biomarker to monitor inflammation in UC. © 2017 John Wiley & Sons Ltd.

Differential Dengue Tropism & Neutralization: Potential Mechanisms of Pathogenesis

DTIC Science & Technology

2006-01-04

Dr. Guillermo Comach and Dr. Daria Camacho, Laboratorio Regional de Diagnostico e Investigacion del Dengue y otras Enfermedades Virales, Centro de... Enfermedades Virales, Centro de Investigaciones Biomedicas de la Universidad de Carabobo (LARDIDEV/BIOMED- UC), Maracay, Venezuela. 4Naval Medical Research

The mixed reality of things: emerging challenges for human-information interaction

NASA Astrophysics Data System (ADS)

Spicer, Ryan P.; Russell, Stephen M.; Rosenberg, Evan Suma

2017-05-01

Virtual and mixed reality technology has advanced tremendously over the past several years. This nascent medium has the potential to transform how people communicate over distance, train for unfamiliar tasks, operate in challenging environments, and how they visualize, interact, and make decisions based on complex data. At the same time, the marketplace has experienced a proliferation of network-connected devices and generalized sensors that are becoming increasingly accessible and ubiquitous. As the "Internet of Things" expands to encompass a predicted 50 billion connected devices by 2020, the volume and complexity of information generated in pervasive and virtualized environments will continue to grow exponentially. The convergence of these trends demands a theoretically grounded research agenda that can address emerging challenges for human-information interaction (HII). Virtual and mixed reality environments can provide controlled settings where HII phenomena can be observed and measured, new theories developed, and novel algorithms and interaction techniques evaluated. In this paper, we describe the intersection of pervasive computing with virtual and mixed reality, identify current research gaps and opportunities to advance the fundamental understanding of HII, and discuss implications for the design and development of cyber-human systems for both military and civilian use.

Detection of sulphur in the galactic center

NASA Technical Reports Server (NTRS)

Herter, T.; Briotta, D. A., Jr.; Gull, G. E.; Shure, M. A.; Houck, J. R.

1983-01-01

A strong detection at the (SIII) 18.71 micron line is reported for the Galactic Center region, Sgr A West. A line flux of 1.7 + or - 0.2x10 to the -17th power W cm(-2) is found for a 20-arc second beam-size measurement centered on IRS 1. A preliminary analysis indicates that the SIII abundance relative to hydrogen is consistent with the cosmic abundance of sulfur, 1.6x10 to the -5th power, if a filling factor of unity within the known clumps is assumed. However, the sulfur abundance in the Galactic Center may be as much as a factor of 3 overabundant if a filling factor of 0.03 is adopted, a value found to hold for some galactic HII regions.

Radio Recombination Line Surveys of the inner Galactic Plane: SIGGMA and GDIGS

NASA Astrophysics Data System (ADS)

Liu, Bin; Anderson, Loren Dean; Luisi, Matteo; Balser, Dana; Bania, Thomas; Wenger, Trey; Haffner, Lawrence Matthew; Minchin, Robert; Roshi, Anish; Churchwell, Edward; Terzian, Yervant; McIntyre, Travis; Lebron, Mayra; SIGGMA team, GDIGS team

2018-01-01

Ionized gas is one of the primary components of the interstellar medium (ISM) and plays a crucial role in star formation and galaxy evolution. Radio recombination lines (RRLs) can directly trace ionized gas in HII regions and warm ionized medium (WIM) without being affected by interstellar extinction. Single-dish telescopes like Arecibo Observatory and the Green Bank Telescope (GBT) are sensitive to low surface brightness emission, and are therefore powerful tools for the study of HII regions and the WIM. We report here on two large surveys of RRL emission: The Survey of Ionized Gas in the Galaxy, Made with the Arecibo telescope (SIGGMA) and the GBT Diffuse Ionized Gas Survey (GDIGS). These are the first large-scale fully-sampled RRL surveys, and together cover nearly the entire first quadrant of the Galactic plane at ~arcmin spatial resolution (l = -5 - 32 deg. for GDIGS and l = 32 - 70 deg. for SIGGMA). SIGGMA is performed with the Arecibo L-band Feed Array (ALFA) receiver, whose bandpass covers twelve hydrogen alpha lines from H163α to H174α. By stacking the α-lines and smoothing to 4 km/s velocity resolution, the final SIGGMA spectra have a mean rms level of ~0.65 mJy per beam. The GDIGS data were taken with the GBT C-band receiver and the VEGAS backend and include RRLs from H95α to H117α, and when stacked and smoothed to 5 km/s resolution achieve 1 mJy per beam rms. Here, we report on early analysis of the SIGGMA and GDIGS data, and present first scientific results.

The violent interstellar medium in Messier 31

NASA Technical Reports Server (NTRS)

Brinks, Elias; Braun, Robert; Unger, Stephen W.

1990-01-01

Taurus observations in the line of H alpha and Very Large Array (VLA) HI mapping of the HII complex No. 722 in M31, reveal what seems to be a spherical cavity 330 pc in diameter blown out by a stellar association of over 20(exp 6) years old. Evidence of induced star formation which was initiated less than 5(exp 6) years ago is present in the form of bright HII emission and numerous O, B and Wolf-Rayet stars which are found within the shell surrounding the cavity. The energy necessary to create the HI shell is estimated to be about 5(exp 51) erg.

H-II Transfer Vehicle (HTV)-4

NASA Image and Video Library

2013-08-09

ISS036-E-030702 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time). A blue and white part of Earth provides the backdrop for the scene.

H-II Transfer Vehicle (HTV)-4

NASA Image and Video Library

2013-08-09

ISS036-E-030638 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time). A blue and white part of Earth provides the backdrop for the scene.

Partnering with K-12 Education in Building Healthy, Sustainable, and Competitive Regions: A California Policy Symposium. Proceedings Summary & Next Steps

ERIC Educational Resources Information Center

Vincent, Jeff; McKoy, Deborah; Alex, Ken; Mitchell, Connie; Moore, Kathleen

2013-01-01

On December 6, 2012, UC Berkeley's Center for Cities & Schools, in collaboration with the California Department of Education, California Department of Public Health, Governor's Office of Planning and Research, Strategic Growth Council, and Health in All Policies Task Force, brought together leaders from across California to discuss the…

Economic evaluation of a disease management program for chronic obstructive pulmonary disease.

PubMed

Dewan, Naresh A; Rice, Kathryn L; Caldwell, Michael; Hilleman, Daniel E

2011-06-01

The data on cost savings with disease management (DM) in chronic obstructive pulmonary disease (COPD) is limited. A multicomponent DM program in COPD has recently shown in a large randomized controlled trial to reduce hospitalizations and emergency department visits compared to usual care (UC). The objectives of this study were to determine the cost of implementing the DM program and its impact on healthcare resource utilization costs compared to UC in high-risk COPD patients. This study was a post-hoc economic analysis of a multicenter randomized, adjudicator-blinded, controlled, 1-year trial comparing DM and UC at 5 Midwest region Department of Veterans Affairs (VA) medical centers. Health-care costs (hospitalizations, ED visits, respiratory medications, and the cost of the DM intervention) were compared in the COPD DM intervention and UC groups. The composite outcome for all hospitalizations or ED visits were 27% lower in the DM group (123.8 mean events per 100 patient-years) compared to the UC group (170.5 mean events per 100 patient-years) (rate ratio 0.73; 0.56-0.90; p < 0.003). The cost of the DM intervention was $241,620 or $650 per patient. The total mean ± SD per patient cost that included the cost of DM in the DM group was 4491 ± 4678 compared to $5084 ± 5060 representing a $593 per patient cost savings for the DM program. The DM intervention program in this study was unique for producing an average cost savings of $593 per patient after paying for the cost of DM intervention.

Possibilities of lunar polar orbiter

NASA Astrophysics Data System (ADS)

Iwata, T.; Nagatomo, M.

This paper describes the concept of a lunar polar orbiter (LPO), which will map the surface of the moon, especially its polar region and the far side, and send precise images of various wave lengths to earth. The primary purpose of the LPO is to identify global and local structures of lunar resources and topography and to search for a suitable site for the manned lunar base projected for next century. The concept of the LPO is based on the H-II rocket (which has a launch capability to send a rover/lander of one metric ton to the lunar surface) and earth observation technology of Japan.

An investigation of the Carina Nebula

NASA Astrophysics Data System (ADS)

Brooks, Kate J.

2000-10-01

It is well known that the radiation fields and stellar winds of massive stars can drastically affect the physical conditions, structure and chemistry of the giant molecular cloud (GMC) from which they formed. It is also thought that massive stars are at least partly responsible for triggering further star formation within a GMC. The details of this interaction, however, are not well understood and additional detailed study of massive star-forming regions is needed. This study has focused on a multi-wavelength investigation of the Carina Nebula. This is a spectacular massive star-forming region that contains two of the most massive star clusters in our galaxy, Trumpler 14 and Trumpler 16, and one of the most massive stars known -- η Car. The goal of this study has been to obtain information on the molecular gas, ionized gas and photodissociation regions (PDRs) from a collection of instruments which have the highest angular resolution and sensitivity available to date. The Mopra Telescope and the Swedish-ESO Submillimeter Telescope (SEST) were used to obtain a series of molecular line observations of the GMC between 150 and 230 GHz. Observations of H110α recombination-line emission at 4.874 GHz and the related continuum emission were obtained with the Australia Telescope Compact Array and used to study the ionized gas associated with the two HII regions, Car I and Car II. H2 1--0 S(1) (2.12 microns) and Brγ (2.16 microns) observations using the University of New South Wales Infrared Fabry-Perot (UNSWIRF) and 3.29 micron narrow-band observations obtained with the SPIREX/Abu thermal infrared camera were used to study the PDRs on the surface of molecular clumps in the Keyhole region, a dark optical feature in the vicinity of η Car. The results of these observations provide detailed information on the excitation conditions, kinematics and morphology of regions within the HII region/molecular cloud complex of the Carina Nebula. In addition, the results confirm that

Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation

PubMed Central

Shono, Akemi; Yoshida, Makiko; Yamana, Keiji; Thwin, Khin Kyae Mon; Kuroda, Jumpei; Kurokawa, Daisuke; Koda, Tsubasa; Nishida, Kosuke; Ikuta, Toshihiko; Mizobuchi, Masami; Taniguchi-Ikeda, Mariko

2017-01-01

Mesenchymal stem cells (MSCs) are a heterogeneous cell population that is isolated initially from the bone marrow (BM) and subsequently almost all tissues including umbilical cord (UC). UC-derived MSCs (UC-MSCs) have attracted an increasing attention as a source for cell therapy against various degenerative diseases due to their vigorous proliferation and differentiation. Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. In the present study, we isolated UC-MSCs from 23 infants delivered at 22–40 weeks of gestation and analyzed their gene expression and cell proliferation. Microarray analysis revealed that global gene expression in preterm UC-MSCs was distinct from term UC-MSCs. WNT signaling impacts on a variety of tissue stem cell proliferation and differentiation, and its pathway genes were enriched in differentially expressed genes between preterm and term UC-MSCs. Cell proliferation of preterm UC-MSCs was significantly enhanced compared to term UC-MSCs and counteracted by WNT signaling inhibitor XAV939. Furthermore, WNT2B expression in UC-MSCs showed a significant negative correlation with gestational age (GA). These results suggest that WNT signaling is involved in the regulation of GA-dependent UC-MSC proliferation. PMID:29138639

VizieR Online Data Catalog: PN and HII regions of West and East of NGC 3109 (Pena+, 2007)

NASA Astrophysics Data System (ADS)

Pena, M.; Richer, M. G.; Stasińska, G.

2007-03-01

Six files (fits format, 16MB) containing images of the West (W) and East (E) zones of NGC 3109 are presented. The images are a combination of frames obtained with the ESO Very Large Telescope and the Focal Reducer Spectrograph FORS1. All the frames were obtained on 29 November and 1 December 2005, with air masses smaller than 1.16 and seeing better than 0.7 arcsec. They constitute the pre-imaging of the ESO program ID 076.B-0166(A). Central coordinates of images are: West side (images named NGC3109W-xxxx.fits) RA=10:02:54.5, DE=-26:09:22, equinox 2000. East side (images named NGC3109E-xxx.fits) RA=10:03:19.8, DE=-26:09:32, equinox 2000. The image size is 6.8x6.8arcmin2. (3 data files).

Receptivity of a Cryogenic Coaxial Gas-Liquid Jet to Acoustic Disturbances (Briefing Charts)

DTIC Science & Technology

2014-03-01

meas = Δt Δs Uc,meas 2/12/1 0 2/12/1 0 , i iio thc UUU      DISTRIBUTION STATEMENT A. Approved for public release; distribution unlimited...this point, dynamic pressures are approximately equal. Uc Uo – Uc Uc – Ui (Uo > Ui) 2/12/1 2/12/1 io iioo c UUU      St = Uc fnatD If St, D, Uc

Human Umbilical Cord Mesenchymal Stem Cells: Subpopulations and Their Difference in Cell Biology and Effects on Retinal Degeneration in RCS Rats.

PubMed

Wang, L; Li, P; Tian, Y; Li, Z; Lian, C; Ou, Q; Jin, C; Gao, F; Xu, J-Y; Wang, J; Wang, F; Zhang, J; Zhang, J; Li, W; Tian, H; Lu, L; Xu, G-T

2017-01-01

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are potential candidates for treating retinal degeneration (RD). To further study the biology and therapeutic effects of the hUC-MSCs on retinal degeneration. Two hUC-MSC subpopulations, termed hUC-MSC1 and hUC-MSC2, were isolated by single-cell cloning method and their therapeutic functions were compared in RCS rat, a RD model. Although both subsets satisfied the basic requirements for hUC-MSCs, they were significantly different in morphology, proliferation rate, differentiation capacity, phenotype and gene expression. Furthermore, only the smaller, fibroblast-like, faster growing subset hUC-MSC1 displayed stronger colony forming potential as well as adipogenic and osteogenic differentiation capacities. When the two subsets were respectively transplanted into the subretinal spaces of RCS rats, both subsets survived, but only hUC-MSC1 expressed RPE cell markers Bestrophin and RPE65. More importantly, hUC-MSC1 showed stronger rescue effect on the retinal function as indicated by the higher b-wave amplitude on ERG examination, thicker retinal nuclear layer, and decreased apoptotic photoreceptors. When both subsets were treated with interleukin-6, mimicking the inflammatory environment when the cells were transplanted into the eyes with degenerated retina, hUC-MSC1 expressed much higher levels of trophic factors in comparison with hUC-MSC2. The data here, in addition to prove the heterogeneity of hUC-MSCs, confirmed that the stronger therapeutic effects of hUC-MSC1 were attributed to its stronger anti-apoptotic effect, paracrine of trophic factors and potential RPE cell differentiation capacity. Thus, the subset hUC-MSC1, not the other subset or the ungrouped hUC-MSCs should be used for effective treatment of RD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Complex molecules in Sagittarius B2(N): The importance of grain chemistry

NASA Technical Reports Server (NTRS)

Miao, Yanti; Mehringer, David M.; Kuan, Yi-Jheng; Snyder, Lewis E.

1995-01-01

The complex molecules vinyl cyanide (CH2CHCN), methyl formate (HCOOCH3), and ethyl cyanide (CH3CH2CN) were observed in the Sgr B2 star-forming region with the BIMA millimeter wavelength array. A region with diameter less than 0.1 pc toward the Sgr B2(N) molecular core is found to be the major source of these molecules. Also, this source is coincident with continuum emission from dust and a center of H2O maser activity. Ultracompact (UC) H 11 regions are located within 0.1 pc. Strikingly, none of these molecules is detected toward Sgr B2(M), a core located 1 minute south of Sgr B2(N). The existence of complex molecules, a large mass of dust, high-velocity H2O masers, and UC H 11 regions strongly suggests that the Sgr B2(N) region has just begun to form stars, while the absence of strong dust emission and large molecules suggests Sgr B2(M) is more evolved. The detection of large molecules coincident with continuum emission from dust supports the idea found in current chemical models that grain chemistry is of crucial importance for the formation of these molecules.

Expression of 9-cis-EPOXYCAROTENOID DIOXYGENASE4 Is Essential for Thermoinhibition of Lettuce Seed Germination but Not for Seed Development or Stress Tolerance[C][W

PubMed Central

Huo, Heqiang; Dahal, Peetambar; Kunusoth, Keshavulu; McCallum, Claire M.; Bradford, Kent J.

2013-01-01

Thermoinhibition, or failure of seeds to germinate at warm temperatures, is common in lettuce (Lactuca sativa) cultivars. Using a recombinant inbred line population developed from a lettuce cultivar (Salinas) and thermotolerant Lactuca serriola accession UC96US23 (UC), we previously mapped a quantitative trait locus associated with thermoinhibition of germination to a genomic region containing a gene encoding a key regulated enzyme in abscisic acid (ABA) biosynthesis, 9-cis-EPOXYCAROTENOID DIOXYGENASE4 (NCED4). NCED4 from either Salinas or UC complements seeds of the Arabidopsis thaliana nced6-1 nced9-1 double mutant by restoring germination thermosensitivity, indicating that both NCED4 genes encode functional proteins. Transgenic expression of Salinas NCED4 in UC seeds resulted in thermoinhibition, whereas silencing of NCED4 in Salinas seeds led to loss of thermoinhibition. Mutations in NCED4 also alleviated thermoinhibition. NCED4 expression was elevated during late seed development but was not required for seed maturation. Heat but not water stress elevated NCED4 expression in leaves, while NCED2 and NCED3 exhibited the opposite responses. Silencing of NCED4 altered the expression of genes involved in ABA, gibberellin, and ethylene biosynthesis and signaling pathways. Together, these data demonstrate that NCED4 expression is required for thermoinhibition of lettuce seeds and that it may play additional roles in plant responses to elevated temperature. PMID:23503626

Oncogenic Activation of Fibroblast Growth Factor Receptor-3 and RAS Genes as Non-Overlapping Mutual Exclusive Events in Urinary Bladder Cancer.

PubMed

Pandith, Arshad A; Hussain, Aashaq; Khan, Mosin S; Shah, Zafar A; Wani, M Saleem; Siddiqi, Mushtaq A

2016-01-01

Urinary bladder cancer is a common malignancy in the West and ranks as the 7th most common cancer in our region of Kashmir, India. FGFR3 mutations are frequent in superficial urothelial carcinoma (UC) differing from the RAS gene mutational pattern. The aim of this study was to analyze the frequency and association of FGFR3 and RAS gene mutations in UC cases. Paired tumor and adjacent normal tissue specimens of 65 consecutive UC patients were examined. DNA preparations were evaluated for the occurrence of FGFR3 and RAS gene mutations by PCR-SCCP and DNA sequencing. Somatic point mutations of FGFR3 were identified in 32.3% (21 of 65). The pattern and distribution were significantly associated with low grade/stage (<0.05). The overall mutations in exon 1 and 2 in all the forms of RAS genes aggregated to 21.5% and showed no association with any clinic-pathological parameters. In total, 53.8% (35 of 65) of the tumors studied had mutations in either a RAS or FGFR3 gene, but these were totally mutually exclusive in and none of the samples showed both the mutational events in mutually exclusive RAS and FGFR3. We conclude that RAS and FGFR3 mutations in UC are mutually exclusive and non-overlapping events which reflect activation of oncogenic pathways through different elements.

Receptivity of a Cryogenic Coaxial Liquid Jet to Acoustic Disturbances

DTIC Science & Technology

2014-05-21

i iio thc UUU DISTRIBUTION STATEMENT A. Approved for public release; distribution unlimited. PA Clearance 14208 12Place Proper DISTRIBUTION STATEMENT...dynamic pressures are approximately equal. Uc Uo – Uc Uc – Ui (Uo > Ui) 2/12/1 2/12/1 io iioo c UUU St = Uc fnatD If St, D, Uc are held constant then

White light emission and effect of annealing on the Ho{sup 3+}–Yb{sup 3+} codoped BaCa{sub 2}Al{sub 8}O{sub 15} phosphor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumari, Astha; Rai, Vineet Kumar, E-mail: vineetkrrai@yahoo.co.in

Graphical abstract: The upconversion emission spectra of the Ho{sup 3+}/Yb{sup 3+} doped/codoped BaCa{sub 2}Al{sub 8}O{sub 15} phosphors with different doping concentrations of Ho{sup 3+}/Yb{sup 3+} ions along with UC emission spectrum of the white light emitting phosphor annealed at 800 °C. - Highlights: • BaCa{sub 2}Al{sub 8}O{sub 15} phosphors codoped with Ho{sup 3+}–Yb{sup 3+} have been prepared by combustion method. • Phosphor annealed at 800 °C, illuminate an intense white light upon NIR excitation. • The sample annealed at higher temperatures emits in the pure green region. • The colour emitted persists in the white region even at high pumpmore » power density. • Developed phosphor is suitable for making upconverters and WLEDs. - Abstract: The BaCa{sub 2}Al{sub 8}O{sub 15} (BCAO) phosphors codoped with suitable Ho{sup 3+}–Yb{sup 3+} dopant concentration prepared by combustion method illuminate an intense white light upon near infrared diode laser excitation. The structural analysis of the phosphors and the detection of impurity contents have been performed by using the X-Ray Diffraction, FESEM and FTIR analysis. The purity of white light emitted from the sample has been confirmed by the CIE chromaticity diagram. Also, the white light emitted from the sample persists with the variation of pump power density. The phosphors emit upconversion (UC) emission bands in the blue, green and red region (three primary colours required for white light emission) along with one more band in the near infrared region of the electromagnetic spectrum. On annealing the white light emitting sample at higher temperatures, the sample starts to emit green colour and also the intensity of green and red UC emission bands get enhanced largely.« less

Model Urbanization Strategy: Summaries, Recommendations and Requirements

EPA Science Inventory

The urban canopy (UC), the layer of the atmosphere between the ground and the top of the highest buildings, is the region where people live and human activities take place. Because of this importance (e.g., human health, preservation of buildings) significant efforts have been de...

COST 728 Project Report: Urbanization of Meteorological and Air Quality Models - Chapter 5 - Model Urbanization Strategy: Summaries, Recommendations and Requirements

EPA Science Inventory

The urban canopy (UC), the layer of the atmosphere between the ground and the top of the highest buildings, is the region where people live and human activities take place. Because of this importance (e.g., human health, preservation of buildings) significant efforts have been d...

Ulcerative colitis-associated colorectal cancer

PubMed Central

Yashiro, Masakazu

2014-01-01

The association between ulcerative colitis (UC) and colorectal cancer (CRC) has been acknowledged. One of the most serious and life threatening consequences of UC is the development of CRC (UC-CRC). UC-CRC patients are younger, more frequently have multiple cancerous lesions, and histologically show mucinous or signet ring cell carcinomas. The risk of CRC begins to increase 8 or 10 years after the diagnosis of UC. Risk factors for CRC with UC patients include young age at diagnosis, longer duration, greater anatomical extent of colonic involvement, the degree of inflammation, family history of CRC, and presence of primary sclerosing cholangitis. CRC on the ground of UC develop from non-dysplastic mucosa to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma. Colonoscopy surveillance programs are recommended to reduce the risk of CRC and mortality in UC. Genetic alterations might play a role in the development of UC-CRC. 5-aminosalicylates might represent a favorable therapeutic option for chemoprevention of CRC. PMID:25469007

HLA is unlikely to be a major component of risk in familial inflammatory bowl disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathew, C.G.; Naom, I.S.; Hodgson, S.V.

1994-09-01

Inflammatory bowel disease (IBD) is a chronic inflammation of the bowel which is confined to the colon in ulcerative colitis (UC) or may affect any part of the gastrointestinal tract in Crohn`s disease (CD). The cause of IBD is unknown, but a genetic component is suggested by a 10-fold increase in risk to first degree relatives, and a higher concordance of disease in MZ versus DZ twins. Distinct associations of HLA DR2 with UC and DR1/DQw5 with CD have been reported. We are searching for susceptibility genes in IBD by linkage analysis in a panel of 43 families with 3more » or more living affected members, which includes 12 families with CD, 17 with UC and 14 {open_quotes}mixed{close_quotes} families with UC and CD. In view of the reported HLA associations in IBD, we have analyzed 5 microsatellite markers from the major histocompatibility complex for linkage to IBD using both parametric and nonparametric methods. LOD scores were calculated for 4 different genetic models, including both dominant and recessive inheritance, and haplotype sharing was analyzed in affected siblings. LOD scores for the MHC locus were negative in the full data set, and in the 3 classes of family (UC,CD,mixed). Haplotype sharing in affected sibs was very close to that expected if no linkage was present. We conclude that genes from the HLA region are unlikely to be a major component of risk in familial IBD. Linkage analysis of genes which cause chronic colitis when disrupted in transgenic mice is in progress.« less

Photon energy upconverting nanopaper: a bioinspired oxygen protection strategy.

PubMed

Svagan, Anna J; Busko, Dmitry; Avlasevich, Yuri; Glasser, Gunnar; Baluschev, Stanislav; Landfester, Katharina

2014-08-26

The development of solid materials which are able to upconvert optical radiation into photons of higher energy is attractive for many applications such as photocatalytic cells and photovoltaic devices. However, to fully exploit triplet-triplet annihilation photon energy upconversion (TTA-UC), oxygen protection is imperative because molecular oxygen is an ultimate quencher of the photon upconversion process. So far, reported solid TTA-UC materials have focused mainly on elastomeric matrices with low barrier properties because the TTA-UC efficiency generally drops significantly in glassy and semicrystalline matrices. To overcome this limit, for example, combine effective and sustainable annihilation upconversion with exhaustive oxygen protection of dyes, we prepare a sustainable solid-state-like material based on nanocellulose. Inspired by the structural buildup of leaves in Nature, we compartmentalize the dyes in the liquid core of nanocellulose-based capsules which are then further embedded in a cellulose nanofibers (NFC) matrix. Using pristine cellulose nanofibers, a sustainable and environmentally friendly functional nanomaterial with ultrahigh barrier properties is achieved. Also, an ensemble of sensitizers and emitter compounds are encapsulated, which allow harvesting of the energy of the whole deep-red sunlight region. The films demonstrate excellent lifetime in synthetic air (20.5/79.5, O2/N2)-even after 1 h operation, the intensity of the TTA-UC signal decreased only 7.8% for the film with 8.8 μm thick NFC coating. The lifetime can be further modulated by the thickness of the protective NFC coating. For comparison, the lifetime of TTA-UC in liquids exposed to air is on the level of seconds to minutes due to fast oxygen quenching.