Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management.

PubMed

Sinnecker, Tim; Kuchling, Joseph; Dusek, Petr; Dörr, Jan; Niendorf, Thoralf; Paul, Friedemann; Wuerfel, Jens

2015-01-01

Conventional magnetic resonance imaging (MRI) at 1.5 Tesla (T) is limited by modest spatial resolution and signal-to-noise ratio (SNR), impeding the identification and classification of inflammatory central nervous system changes in current clinical practice. Gaining from enhanced susceptibility effects and improved SNR, ultrahigh field MRI at 7 T depicts inflammatory brain lesions in great detail. This review summarises recent reports on 7 T MRI in neuroinflammatory diseases and addresses the question as to whether ultrahigh field MRI may eventually improve clinical decision-making and personalised disease management.

Advancement in the Understanding of the Field and Frequency Dependent Microwave Surface Resistance of Niobium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martinello, M.; Aderhold, S.; Chandrasekaran, S. K.

The radio-frequency surface resistance of niobium resonators is incredibly reduced when nitrogen impurities are dissolved as interstitial in the material, conferring ultra-high Q-factors at medium values of accelerating field. This effect has been observed in both high and low temperature nitrogen treatments. As a matter of fact, the peculiar anti Q-slope observed in nitrogen doped cavities, i.e. the decreasing of the Q-factor with the increasing of the radio-frequency field, come from the decreasing of the BCS surface resistance component as a function of the field. Such peculiar behavior has been considered consequence of the interstitial nitrogen present in the niobiummore » lattice after the doping treatment. The study here presented show the field dependence of the BCS surface resistance of cavities with different resonant frequencies, such as: 650 MHz, 1.3 GHz, 2.6 GHz and 3.9 GHz, and processed with different state-of-the-art surface treatments. These findings show for the first time that the anti Q-slope might be seen at high frequency even for clean Niobium cavities, revealing useful suggestion on the physics underneath the anti Q-slope effect.« less

Design and Test of Magnetic Wall Decoupling for Dipole Transmit/Receive Array for MR Imaging at the Ultrahigh Field of 7T.

PubMed

Yan, Xinqiang; Zhang, Xiaoliang; Wei, Long; Xue, Rong

2015-01-01

Radio-frequency coil arrays using dipole antenna technique have been recently applied for ultrahigh field magnetic resonance (MR) imaging to obtain the better signal-noise-ratio (SNR) gain at the deep area of human tissues. However, the unique structure of dipole antennas makes it challenging to achieve sufficient electromagnetic decoupling among the dipole antenna elements. Currently, there is no decoupling methods proposed for dipole antenna arrays in MR imaging. The recently developed magnetic wall (MW) or induced current elimination decoupling technique has demonstrated its feasibility and robustness in designing microstrip transmission line arrays, L/C loop arrays and monopole arrays. In this study, we aim to investigate the possibility and performance of MW decoupling technique in dipole arrays for MR imaging at the ultrahigh field of 7T. To achieve this goal, a two-channel MW decoupled dipole array was designed, constructed and analyzed experimentally through bench test and MR imaging. Electromagnetic isolation between the two dipole elements was improved from about -3.6 dB (without any decoupling treatments) to -16.5 dB by using the MW decoupling method. MR images acquired from a water phantom using the MW decoupled dipole array and the geometry factor maps were measured, calculated and compared with those acquired using the dipole array without decoupling treatments. The MW decoupled dipole array demonstrated well-defined image profiles from each element and had better geometry factor over the array without decoupling treatments. The experimental results indicate that the MW decoupling technique might be a promising solution to reducing the electromagnetic coupling of dipole arrays in ultrahigh field MRI, consequently improving their performance in SNR and parallel imaging.

Splice length of prestressing strand in field-cast ultra-high performance concrete connections, TechBrief

DOT National Transportation Integrated Search

2014-02-02

The objective of this research was to determine the lap splice length of untensioned prestressing strand in field-cast ultrahigh performance concrete (UHPC). This document is a technical summary of the Federal Highway Administration report, Splice Le...

Long range ultra-high frequency (UHF) radio frequency identification (RFID) antenna design

NASA Astrophysics Data System (ADS)

Reynolds, Nathan D.

There is an ever-increasing demand for radio frequency identification (RFID) tags that are passive, long range, and mountable on multiple surfaces. Currently, RFID technology is utilized in numerous applications such as supply chain management, access control, and public transportation. With the combination of sensory systems in recent years, the applications of RFID technology have been extended beyond tracking and identifying. This extension includes applications such as environmental monitoring and healthcare applications. The available sensory systems usually operate in the medium or high frequency bands and have a low read range. However, the range limitations of these systems are being overcome by the development of RFID sensors focused on utilizing tags in the ultra-high frequency (UHF) band. Generally, RFID tags have to be mounted to the object that is being identified. Often the objects requiring identification are metallic. The inherent properties of metallic objects have substantial effects on nearby electromagnetic radiation; therefore, the operation of the tag antenna is affected when mounted on a metallic surface. This outlines one of the most challenging problems for RFID systems today: the optimization of tag antenna performance in a complex environment. In this research, a novel UHF RFID tag antenna, which has a low profile, long range, and is mountable on metallic surfaces, is designed analytically and simulated using a 3-D electromagnetic simulator, ANSYS HFSS. A microstrip patch antenna is selected as the antenna structure, as patch antennas are low profile and suitable for mounting on metallic surfaces. Matching and theoretical models of the microstrip patch antenna are investigated. Once matching and theory of a microstrip patch antenna is thoroughly understood, a unique design technique using electromagnetic band gap (EBG) structures is explored. This research shows that the utilization of an EBG structure in the patch antenna design yields

An adjustable multi-scale single beam acoustic tweezers based on ultrahigh frequency ultrasonic transducer.

PubMed

Chen, Xiaoyang; Lam, Kwok Ho; Chen, Ruimin; Chen, Zeyu; Yu, Ping; Chen, Zhongping; Shung, K Kirk; Zhou, Qifa

2017-11-01

This paper reports the fabrication, characterization, and microparticle manipulation capability of an adjustable multi-scale single beam acoustic tweezers (SBAT) that is capable of flexibly changing the size of "tweezers" like ordinary metal tweezers with a single-element ultrahigh frequency (UHF) ultrasonic transducer. The measured resonant frequency of the developed transducer at 526 MHz is the highest frequency of piezoelectric single crystal based ultrasonic transducers ever reported. This focused UHF ultrasonic transducer exhibits a wide bandwidth (95.5% at -10 dB) due to high attenuation of high-frequency ultrasound wave, which allows the SBAT effectively excite with a wide range of excitation frequency from 150 to 400 MHz by using the "piezoelectric actuator" model. Through controlling the excitation frequency, the wavelength of ultrasound emitted from the SBAT can be changed to selectively manipulate a single microparticle of different sizes (3-100 μm) by using only one transducer. This concept of flexibly changing "tweezers" size is firstly introduced into the study of SBAT. At the same time, it was found that this incident ultrasound wavelength play an important role in lateral trapping and manipulation for microparticle of different sizes. Biotechnol. Bioeng. 2017;114: 2637-2647. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Clinical applications at ultrahigh field (7  T). Where does it make the difference?

PubMed

Trattnig, Siegfried; Bogner, Wolfgang; Gruber, Stephan; Szomolanyi, Pavol; Juras, Vladimir; Robinson, Simon; Zbýň, Štefan; Haneder, Stefan

2016-09-01

Presently, three major MR vendors provide commercial 7-T units for clinical research under ethical permission, with the number of operating 7-T systems having increased to over 50. This rapid increase indicates the growing interest in ultrahigh-field MRI because of improved clinical results with regard to morphological as well as functional and metabolic capabilities. As the signal-to-noise ratio scales linearly with the field strength (B0 ) of the scanner, the most obvious application at 7 T is to obtain higher spatial resolution in the brain, musculoskeletal system and breast. Of specific clinical interest for neuro-applications is the cerebral cortex at 7 T, for the detection of changes in cortical structure as a sign of early dementia, as well as for the visualization of cortical microinfarcts and cortical plaques in multiple sclerosis. In the imaging of the hippocampus, even subfields of the internal hippocampal anatomy and pathology can be visualized with excellent resolution. The dynamic and static blood oxygenation level-dependent contrast increases linearly with the field strength, which significantly improves the pre-surgical evaluation of eloquent areas before tumor removal. Using susceptibility-weighted imaging, the plaque-vessel relationship and iron accumulation in multiple sclerosis can be visualized for the first time. Multi-nuclear clinical applications, such as sodium imaging for the evaluation of repair tissue quality after cartilage transplantation and (31) P spectroscopy for the differentiation between non-alcoholic benign liver disease and potentially progressive steatohepatitis, are only possible at ultrahigh fields. Although neuro- and musculoskeletal imaging have already demonstrated the clinical superiority of ultrahigh fields, whole-body clinical applications at 7 T are still limited, mainly because of the lack of suitable coils. The purpose of this article was therefore to review the clinical studies that have been performed thus

Ultrahigh Energy Density in SrTiO3 Film Capacitors.

PubMed

Hou, Chuangming; Huang, Weichuan; Zhao, Wenbo; Zhang, Dalong; Yin, Yuewei; Li, Xiaoguang

2017-06-21

Solid-state dielectric film capacitors with high-energy-storage density will further promote advanced electronic devices and electrical power systems toward miniaturization, lightweight, and integration. In this study, the influence of interface and thickness on energy storage properties of SrTiO 3 (STO) films grown on La 0.67 Sr 0.33 MnO 3 (LSMO) electrode are systematically studied. The cross-sectional high resolution transmission electron microscopy reveals an ion interdiffusion layer and oxygen vacancies at the STO/LSMO interface. The capacitors show good frequency stability and increased dielectric constant with increasing STO thickness (410-710 nm). The breakdown strength (E b ) increases with decreasing STO thickness and reaches 6.8 MV/cm. Interestingly, the E b under positive field is enhanced significantly and an ultrahigh energy density up to 307 J/cm 3 with a high efficiency of 89% is realized. The enhanced E b may be related to the modulation of local electric field and redistribution of oxygen vacancies at the STO/LSMO interface. Our results should be helpful for potential strategies to design devices with ultrahigh energy density.

Investigation of Molecular Exchange Using DEXSY with Ultra-High Pulsed Field Gradients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gratz, Marcel; Galvosas, Petrik

2008-12-05

Diffusion exchange spectroscopy has been employed for the investigation of water exchange between different regions of a cosmetic lotion as well as for the exchange of n-pentane between the inter- and intra-crystalline space in zeolite NaX. We successfully combined this two-dimensional (2D) NMR experiment with methods for the application of ultra-high pulsed field gradients of up to 35 T/m, resulting in observation times and mixing times as short as 2 ms and 2.8 ms, respectively.

Temporal reliability of ultra-high field resting-state MRI for single-subject sensorimotor and language mapping.

PubMed

Branco, Paulo; Seixas, Daniela; Castro, São Luís

2018-03-01

Resting-state fMRI is a well-suited technique to map functional networks in the brain because unlike task-based approaches it requires little collaboration from subjects. This is especially relevant in clinical settings where a number of subjects cannot comply with task demands. Previous studies using conventional scanner fields have shown that resting-state fMRI is able to map functional networks in single subjects, albeit with moderate temporal reliability. Ultra-high resolution (7T) imaging provides higher signal-to-noise ratio and better spatial resolution and is thus well suited to assess the temporal reliability of mapping results, and to determine if resting-state fMRI can be applied in clinical decision making including preoperative planning. We used resting-state fMRI at ultra-high resolution to examine whether the sensorimotor and language networks are reliable over time - same session and one week after. Resting-state networks were identified for all subjects and sessions with good accuracy. Both networks were well delimited within classical regions of interest. Mapping was temporally reliable at short and medium time-scales as demonstrated by high values of overlap in the same session and one week after for both networks. Results were stable independently of data quality metrics and physiological variables. Taken together, these findings provide strong support for the suitability of ultra-high field resting-state fMRI mapping at the single-subject level. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Development of lead-free single-element ultrahigh frequency (170 – 320 MHz) ultrasonic transducers

PubMed Central

Lam, Kwok Ho; Ji, Hong Fen; Zheng, Fan; Ren, Wei; Zhou, Qifa; Shung, K. Kirk

2013-01-01

This paper presents the design, fabrication and characterization of single-element ultrahigh frequency (UHF) ultrasonic transducers in which the center frequency ranged from 170 to 320 MHz. The center frequency of > 300 MHz is the highest value of lead-free ceramic ultrasonic transducers ever reported. With concern in the environmental pollution of lead-based materials, the transducer elements presented in this work were lead-free K0.5Na0.5NbO3/Bi0.5Na0.5TiO3 (KNN/BNT) composite thick films. All transducers were evaluated in a pulse-echo arrangement. The measured −6 dB bandwidth of the transducers ranged from 35 to 64 %. With the optimized piezoelectric properties of the composite film, the insertion loss of the UHF transducers was measured and determined to range from −50 to −60 dB. In addition to the pulse-echo measurement, a 6-μm tungsten wire phantom was also imaged with a 205 MHz transducer to demonstrate the imaging capability. The measured −6 dB axial and lateral resolutions were found to be 12 μm and 50 μm, respectively. The transducer performance presented in this work is shown to be better or comparable to previously reported results even though the frequency is much higher. PMID:23485349

27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells

PubMed Central

Zhang, Lei; Hou, Yubin; Li, Zhiyuan; Ji, Xinmiao; Wang, Ze; Wang, Huizhen; Tian, Xiaofei; Yu, Fazhi; Yang, Zhenye; Pi, Li; Mitchison, Timothy J; Lu, Qingyou; Zhang, Xin

2017-01-01

Purified microtubules have been shown to align along the static magnetic field (SMF) in vitro because of their diamagnetic anisotropy. However, whether mitotic spindle in mammalian cells can be aligned by magnetic field has not been experimentally proved. In particular, the biological effects of SMF of above 20 T (Tesla) on mammalian cells have never been reported. Here we found that in both CNE-2Z and RPE1 human cells spindle orients in 27 T SMF. The direction of spindle alignment depended on the extent to which chromosomes were aligned to form a planar metaphase plate. Our results show that the magnetic torque acts on both microtubules and chromosomes, and the preferred direction of spindle alignment relative to the field depends more on chromosome alignment than microtubules. In addition, spindle morphology was also perturbed by 27 T SMF. This is the first reported study that investigated the mammalian cellular responses to ultra-high magnetic field of above 20 T. Our study not only found that ultra-high magnetic field can change the orientation and morphology of mitotic spindles, but also provided a tool to probe the role of spindle orientation and perturbation in developmental and cancer biology. DOI: http://dx.doi.org/10.7554/eLife.22911.001 PMID:28244368

A Simple Semaphore Signaling Technique for Ultra-High Frequency Spacecraft Communications

NASA Technical Reports Server (NTRS)

Butman, S.; Satorius, E.; Ilott, P.

2005-01-01

For planetary lander missions such as the upcoming Phoenix mission to Mars, the most challenging phase of the spacecraft-to-ground communications is during the critical phase termed entry, descent, and landing (EDL). At 8.4 GHz (X-band), the signals received by the largest Deep Space Network (DSN) antennas can be too weak for even 1 bit per second (bps) and therefore not able to communicate critical information to Earth. Fortunately, the lander s ultra-high frequency (UHF) link to an orbiting relay can meet the EDL requirements, but the data rate needs to be low enough to fit the capability of the UHF link during some or all of EDL. On Phoenix, the minimum data rate of the as-built UHF radio is 8 kbps and requires a signal level at the Odyssey orbiter of at least -120 dBm. For lower signaling levels, the effective data rate needs to be reduced, but without incurring the cost of rebuilding and requalifying the equipment. To address this scenario, a simple form of frequency-shift keying (FSK) has been devised by appropriately programming the data stream that is input to the UHF transceiver. This article describes this technique and provides performance estimates. Laboratory testing reveals that input signal levels at -140 dBm and lower can routinely be demodulated with the proposed signaling scheme, thereby providing a 20-dB and greater margin over the 8-kbps threshold.

A Simple Semaphore Signaling Technique for Ultra-High Frequency Spacecraft Communications

NASA Astrophysics Data System (ADS)

Butman, S.; Satorius, E.; Illott, P.

2005-11-01

For planetary lander missions such as the upcoming Phoenix mission to Mars, the most challenging phase of the spacecraft-to-ground communications is during the critical phase termed entry, descent, and landing (EDL). At 8.4 GHz (X-band), the signals received by the largest Deep Space Network (DSN) antennas can be too weak for even 1 bit per second (bps) and therefore not able to communicate critical information to Earth. Fortunately, the lander's ultra-high frequency (UHF) link to an orbiting relay can meet the EDL requirements, but the data rate needs to be low enough to fit the capability of the UHF link during some or all of EDL. On Phoenix, the minimum data rate of the as-built UHF radio is 8 kbps and requires a signal level at the Odyssey orbiter of at least minus 120 dBm. For lower signaling levels, the effective data rate needs to be reduced, but without incurring the cost of rebuilding and requalifying the equipment. To address this scenario, a simple form of frequency-shift keying (FSK) has been devised by appropriately programming the data stream that is input to the UHF transceiver. This article describes this technique and provides performance estimates. Laboratory testing reveals that input signal levels at minus 140 dBm and lower can routinely be demodulated with the proposed signaling scheme, thereby providing a 20-dB and greater margin over the 8-kbps threshold.

Progress and promises of human cardiac magnetic resonance at ultrahigh fields: a physics perspective.

PubMed

Niendorf, Thoralf; Graessl, Andreas; Thalhammer, Christof; Dieringer, Matthias A; Kraus, Oliver; Santoro, Davide; Fuchs, Katharina; Hezel, Fabian; Waiczies, Sonia; Ittermann, Bernd; Winter, Lukas

2013-04-01

A growing number of reports eloquently speak about explorations into cardiac magnetic resonance (CMR) at ultrahigh magnetic fields (B0≥7.0 T). Realizing the progress, promises and challenges of ultrahigh field (UHF) CMR this perspective outlines current trends in enabling MR technology tailored for cardiac MR in the short wavelength regime. For this purpose many channel radiofrequency (RF) technology concepts are outlined. Basic principles of mapping and shimming of transmission fields including RF power deposition considerations are presented. Explorations motivated by the safe operation of UHF-CMR even in the presence of conductive implants are described together with the physics, numerical simulations and experiments, all of which detailing antenna effects and RF heating induced by intracoronary stents at 7.0 T. Early applications of CMR at 7.0 T and their clinical implications for explorations into cardiovascular diseases are explored including assessment of cardiac function, myocardial tissue characterization, MR angiography of large and small vessels as well as heteronuclear MR of the heart and the skin. A concluding section ventures a glance beyond the horizon and explores future directions. The goal here is not to be comprehensive but to inspire the biomedical and diagnostic imaging communities to throw further weight behind the solution of the many remaining unsolved problems and technical obstacles of UHF-CMR with the goal to transfer MR physics driven methodological advancements into extra clinical value. Copyright © 2012 Elsevier Inc. All rights reserved.

Simulations of ultra-high energy cosmic rays in the local Universe and the origin of cosmic magnetic fields

NASA Astrophysics Data System (ADS)

Hackstein, S.; Vazza, F.; Brüggen, M.; Sorce, J. G.; Gottlöber, S.

2018-04-01

We simulate the propagation of cosmic rays at ultra-high energies, ≳1018 eV, in models of extragalactic magnetic fields in constrained simulations of the local Universe. We use constrained initial conditions with the cosmological magnetohydrodynamics code ENZO. The resulting models of the distribution of magnetic fields in the local Universe are used in the CRPROPA code to simulate the propagation of ultra-high energy cosmic rays. We investigate the impact of six different magneto-genesis scenarios, both primordial and astrophysical, on the propagation of cosmic rays over cosmological distances. Moreover, we study the influence of different source distributions around the Milky Way. Our study shows that different scenarios of magneto-genesis do not have a large impact on the anisotropy measurements of ultra-high energy cosmic rays. However, at high energies above the Greisen-Zatsepin-Kuzmin (GZK)-limit, there is anisotropy caused by the distribution of nearby sources, independent of the magnetic field model. This provides a chance to identify cosmic ray sources with future full-sky measurements and high number statistics at the highest energies. Finally, we compare our results to the dipole signal measured by the Pierre Auger Observatory. All our source models and magnetic field models could reproduce the observed dipole amplitude with a pure iron injection composition. Our results indicate that the dipole is observed due to clustering of secondary nuclei in direction of nearby sources of heavy nuclei. A light injection composition is disfavoured, since the increase in dipole angular power from 4 to 8 EeV is too slow compared to observation by the Pierre Auger Observatory.

Ultra-high field magnets for whole-body MRI

NASA Astrophysics Data System (ADS)

Warner, Rory

2016-09-01

For whole-body MRI, an ultra-high field (UHF) magnet is currently defined as a system operating at 7 T or above. Over 70 UHF magnets have been built, all with the same technical approach originally developed by Magnex Scientific Ltd. The preferred coil configuration is a compensated solenoid. In this case, the majority of the field is generated by a simple long solenoid that stretches the entire length of the magnet. Additional coils are wound on a separate former outside the main windings with the purpose of balancing the homogeneity. Most of the magnets currently in operation are passively shielded systems where the magnet is surrounded by a steel box of 200-870 tonnes of carbon steel. More recently actively shielded magnets have been built for operation at 7 T; in this case the stray field is controlled by with reverse turns wound on a separate former outside the primary coils. Protection against quench damage is much more complex with an actively shielded magnet design due to the requirement to prevent the stray field from increasing during a quench. In the case of the 7 T 900 magnet this controlled by combining some of the screening coils into each section of the protection circuit. Correction of the field variations caused by manufacturing tolerances and environmental effects are made with a combination of superconducting shims and passive shims. Modern UHF magnets operate in zero boil-off mode with the use of cryocoolers with cooling capacity at 4.2 K. Although there are no cryogen costs associated with normal operation UHF magnets require a significant volume (10 000-20 000 l) of liquid helium for the cool-down. Liquid helium is expensive therefore new methods of cool-down using high-power cryocoolers are being implemented to reduce the requirement.

Ultrahigh Frequency Nanomechanical Piezoresistive Amplifiers for Direct Channel-Selective Receiver Front-Ends.

PubMed

Ramezany, Alireza; Pourkamali, Siavash

2018-04-11

Channel-selective filtering and amplification in ultrahigh frequency (UHF) receiver front-ends are crucial for realization of cognitive radio systems and the future of wireless communication. In the past decade, there have been significant advances in the performance of microscale electromechanical resonant devices. However, such devices have not yet been able to meet the requirements for direct channel selection at RF. They also occupy a relatively large area on the chip making implementation of large arrays to cover several frequency bands challenging. On the other hand, electromechanical piezoresistive resonant devices are active devices that have recently shown the possibility of simultaneous signal amplification and channel-select filtering at lower frequencies. It has been theoretically predicted that if scaled down into the nanoscale, they can operate in the UHF range with a very low power consumption. Here, for the first time nanomechanical piezoresistive amplifiers with active element dimensions as small as 50 nm × 200 nm are demonstrated. With a device area of less than 1.5 μm 2 a piezoresistive amplifier operating at 730 MHz shows effective quality factor ( Q) of 89,000 for a 50Ω load and gains as high as 10 dB and Q of 330,000 for a 250Ω load while consuming 189 μW of power. On the basis of the measurement results, it is shown that for piezoresistor dimensions of 30 nm × 100 nm it is possible to get a similar performance at 2.4 GHz with device footprint of less than 0.2 μm 2 .

Ultrahigh density alignment of carbon nanotube arrays by dielectrophoresis.

PubMed

Shekhar, Shashank; Stokes, Paul; Khondaker, Saiful I

2011-03-22

We report ultrahigh density assembly of aligned single-walled carbon nanotube (SWNT) two-dimensional arrays via AC dielectrophoresis using high-quality surfactant-free and stable SWNT solutions. After optimization of frequency and trapping time, we can reproducibly control the linear density of the SWNT between prefabricated electrodes from 0.5 SWNT/μm to more than 30 SWNT/μm by tuning the concentration of the nanotubes in the solution. Our maximum density of 30 SWNT/μm is the highest for aligned arrays via any solution processing technique reported so far. Further increase of SWNT concentration results in a dense array with multiple layers. We discuss how the orientation and density of the nanotubes vary with concentrations and channel lengths. Electrical measurement data show that the densely packed aligned arrays have low sheet resistances. Selective removal of metallic SWNTs via controlled electrical breakdown produced field-effect transistors with high current on-off ratio. Ultrahigh density alignment reported here will have important implications in fabricating high-quality devices for digital and analog electronics.

High-frequency (13.56-MHz) and ultrahigh-frequency (915-MHz) radio identification systems do not affect platelet activation and functions.

PubMed

Rogowska, Anna; Chabowska, Anna Małgorzata; Lipska, Alina; Boczkowska-Radziwon, Barbara; Bujno, Magdalena; Rusak, Tomasz; Dziemianczuk, Mateusz; Radziwon, Piotr

2016-05-01

In radiofrequency identification (RFID) systems used in labeling of blood components, blood cells are subjected to the direct influence of electromagnetic waves throughout the storage period. The aim of this study was to prove the safety of storage of platelet concentrates (PCs) in containers labeled with RFID tags. Ten pooled PCs obtained from 12 buffy coats each suspended in additive solution were divided into three separate containers that were assigned to three groups: control, PCs labeled with ultrahigh frequency (UHF) range tags and exposed to 915-MHz radio waves, and PCs labeled with high-frequency (HF) range tags and exposed to 13.56-MHz radio waves. PCs were stored at 20 to 24°C for 7 days. In vitro tests of platelet (PLT) function were performed on the first, fifth, and seventh days of storage. There were no significant differences in pH; hypotonic shock resistance; surface expression of CD62P, CD42a, or CD63; release of PLT-derived microparticles; PLT aggregation; and number of PLTs between PCs stored at a constant exposure to radio waves of two different frequencies and the control group on the first, fifth, and seventh days of storage. The results of the study indicate no impact of electromagnetic radiation generated in HF and UHF RFID systems and constant contact with the tags on the quality of stored PCs. © 2016 AABB.

Ultrahigh resolution optical coherence elastography using a Bessel beam for extended depth of field

NASA Astrophysics Data System (ADS)

Curatolo, Andrea; Villiger, Martin; Lorenser, Dirk; Wijesinghe, Philip; Fritz, Alexander; Kennedy, Brendan F.; Sampson, David D.

2016-03-01

Visualizing stiffness within the local tissue environment at the cellular and sub-cellular level promises to provide insight into the genesis and progression of disease. In this paper, we propose ultrahigh-resolution optical coherence elastography, and demonstrate three-dimensional imaging of local axial strain of tissues undergoing compressive loading. The technique employs a dual-arm extended focus optical coherence microscope to measure tissue displacement under compression. The system uses a broad bandwidth supercontinuum source for ultrahigh axial resolution, Bessel beam illumination and Gaussian beam detection, maintaining sub-2 μm transverse resolution over nearly 100 μm depth of field, and spectral-domain detection allowing high displacement sensitivity. The system produces strain elastograms with a record resolution (x,y,z) of 2×2×15 μm. We benchmark the advances in terms of resolution and strain sensitivity by imaging a suitable inclusion phantom. We also demonstrate this performance on freshly excised mouse aorta and reveal the mechanical heterogeneity of vascular smooth muscle cells and elastin sheets, otherwise unresolved in a typical, lower resolution optical coherence elastography system.

The frequency-difference and frequency-sum acoustic-field autoproducts.

PubMed

Worthmann, Brian M; Dowling, David R

2017-06-01

The frequency-difference and frequency-sum autoproducts are quadratic products of solutions of the Helmholtz equation at two different frequencies (ω + and ω - ), and may be constructed from the Fourier transform of any time-domain acoustic field. Interestingly, the autoproducts may carry wave-field information at the difference (ω + - ω - ) and sum (ω + + ω - ) frequencies even though these frequencies may not be present in the original acoustic field. This paper provides analytical and simulation results that justify and illustrate this possibility, and indicate its limitations. The analysis is based on the inhomogeneous Helmholtz equation and its solutions while the simulations are for a point source in a homogeneous half-space bounded by a perfectly reflecting surface. The analysis suggests that the autoproducts have a spatial phase structure similar to that of a true acoustic field at the difference and sum frequencies if the in-band acoustic field is a plane or spherical wave. For multi-ray-path environments, this phase structure similarity persists in portions of the autoproduct fields that are not suppressed by bandwidth averaging. Discrepancies between the bandwidth-averaged autoproducts and true out-of-band acoustic fields (with potentially modified boundary conditions) scale inversely with the product of the bandwidth and ray-path arrival time differences.

Ultrahigh-Resolution Magnetic Resonance in Inhomogeneous Magnetic Fields: Two-Dimensional Long-Lived-Coherence Correlation Spectroscopy

NASA Astrophysics Data System (ADS)

Chinthalapalli, Srinivas; Bornet, Aurélien; Segawa, Takuya F.; Sarkar, Riddhiman; Jannin, Sami; Bodenhausen, Geoffrey

2012-07-01

A half-century quest for improving resolution in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) has enabled the study of molecular structures, biological interactions, and fine details of anatomy. This progress largely relied on the advent of sophisticated superconducting magnets that can provide stable and homogeneous fields with temporal and spatial variations below ΔB0/B0<0.01ppm. In many cases however, inherent properties of the objects under investigation, pulsating arteries, breathing lungs, tissue-air interfaces, surgical implants, etc., lead to fluctuations and losses of local homogeneity. A new method dubbed “long-lived-coherence correlation spectroscopy” (LLC-COSY) opens the way to overcome both inhomogeneous and homogeneous broadening, which arise from local variations in static fields and fluctuating dipole-dipole interactions, respectively. LLC-COSY makes it possible to obtain ultrahigh resolution two-dimensional spectra, with linewidths on the order of Δν=0.1 to 1 Hz, even in very inhomogeneous fields (ΔB0/B0>10ppm or 5000 Hz at 9.7 T), and can improve resolution by a factor up to 9 when the homogeneous linewidths are determined by dipole-dipole interactions. The resulting LLC-COSY spectra display chemical shift differences and scalar couplings in two orthogonal dimensions, like in “J spectroscopy.” LLC-COSY does not require any sophisticated gradient switching or frequency-modulated pulses. Applications to in-cell NMR and to magnetic resonance spectroscopy (MRS) of selected volume elements in MRI appear promising, particularly when susceptibility variations tend to preclude high resolution.

Post-mortem inference of the human hippocampal connectivity and microstructure using ultra-high field diffusion MRI at 11.7 T.

PubMed

Beaujoin, Justine; Palomero-Gallagher, Nicola; Boumezbeur, Fawzi; Axer, Markus; Bernard, Jeremy; Poupon, Fabrice; Schmitz, Daniel; Mangin, Jean-François; Poupon, Cyril

2018-06-01

The human hippocampus plays a key role in memory management and is one of the first structures affected by Alzheimer's disease. Ultra-high magnetic resonance imaging provides access to its inner structure in vivo. However, gradient limitations on clinical systems hinder access to its inner connectivity and microstructure. A major target of this paper is the demonstration of diffusion MRI potential, using ultra-high field (11.7 T) and strong gradients (750 mT/m), to reveal the extra- and intra-hippocampal connectivity in addition to its microstructure. To this purpose, a multiple-shell diffusion-weighted acquisition protocol was developed to reach an ultra-high spatio-angular resolution with a good signal-to-noise ratio. The MRI data set was analyzed using analytical Q-Ball Imaging, Diffusion Tensor Imaging (DTI), and Neurite Orientation Dispersion and Density Imaging models. High Angular Resolution Diffusion Imaging estimates allowed us to obtain an accurate tractography resolving more complex fiber architecture than DTI models, and subsequently provided a map of the cross-regional connectivity. The neurite density was akin to that found in the histological literature, revealing the three hippocampal layers. Moreover, a gradient of connectivity and neurite density was observed between the anterior and the posterior part of the hippocampus. These results demonstrate that ex vivo ultra-high field/ultra-high gradients diffusion-weighted MRI allows the mapping of the inner connectivity of the human hippocampus, its microstructure, and to accurately reconstruct elements of the polysynaptic intra-hippocampal pathway using fiber tractography techniques at very high spatial/angular resolutions.

Ultrahigh near infrared photoresponsive organic field-effect transistors with lead phthalocyanine/C60 heterojunction on poly(vinyl alcohol) gate dielectric.

PubMed

Sun, Lei; Zhang, Jianping; Zhao, Feiyu; Luo, Xiao; Lv, Wenli; li, Yao; Ren, Qiang; Wen, Zhanwei; Peng, Yingquan; Liu, Xingyuan

2015-05-08

Performances of photoresponsive organic field-effect transistors (photOFETs) operating in the near infrared (NIR) region utilizing SiO2 as the gate dielectric is generally low due to low carrier mobility of the channel. We report on NIR photOFETs based on lead phthalocyanine (PbPc)/C60 heterojunction with ultrahigh photoresponsivity by utilizing poly(vinyl alcohol) (PVA) as the gate dielectric. For 808 nm NIR illumination of 1.69 mW cm(-2), an ultrahigh photoresponsivity of 21 A W(-1), and an external quantum efficiency of 3230% were obtained at a gate voltage of 30 V and a drain voltage of 80 V, which are 124 times and 126 times as large as the reference device with SiO2 as the gate dielectric, respectively. The ultrahigh enhancement of photoresponsivity is resulted from the huge increase of electron mobility of C60 film grown on PVA dielectric. AFM investigations revealed that the C60 film grown on PVA is much smooth and uniform and the grain size is much larger than that grown on SiO2 dielectric, which together results in four orders of magnitude increase of the field-effect electron mobility of C60 film.

Ultra-high field MRI for primate imaging using the travelling-wave concept.

PubMed

Mallow, Johannes; Herrmann, Tim; Kim, Kyoung-Nam; Stadler, Joerg; Mylius, Judith; Brosch, Michael; Bernarding, Johannes

2013-08-01

Ultra-high field (UHF) neuroimaging is usually conducted with volume transmit (Tx) and phased array receive (Rx) coils, both tightly enclosing the object. The travelling-wave (TW) concept allows a remote excitation offering more flexible experimental setups. To investigate the feasibility of primate MRI in horizontal UHF MRI, we first compared the distribution of the electromagnetic fields in an oil phantom and then verified the concept with an in vivo experiment. In the phantom experiments an in-house circularly polarized hybrid birdcage coil and a self-developed patch antenna were used for Tx and an eight-element phased array antenna for Rx. B1+ fields were calculated and measured for both approaches. For in vivo experiments the Rx part was replaced with an optimized three-element phased array head coil. The SAR was calculated using field simulation. In the phantom the field distribution was homogenous in a central volume of interest of about 10 cm diameter. The TW concept showed a slightly better homogeneity. Examination of a female crab-eating macaque led to homogeneous high-contrast images with a good delineation of anatomical details. The TW concept opens up a new approach for MRI of medium-sized animals in horizontal UHF scanners.

R&D Progress of HTS Magnet Project for Ultrahigh-field MRI

NASA Astrophysics Data System (ADS)

Tosaka, Taizo; Miyazaki, Hiroshi; Iwai, Sadanori; Otani, Yasumi; Takahashi, Masahiko; Tasaki, Kenji; Nomura, Shunji; Kurusu, Tsutomu; Ueda, Hiroshi; Noguchi, So; Ishiyama, Atsushi; Urayama, Shinichi; Fukuyama, Hidenao

An R&D project on high-temperature superconducting (HTS) magnets using rare-earth Ba2Cu3O7 (REBCO) wires was started in 2013. The project objective is to investigate the feasibility of adapting REBCO magnets to ultrahigh field (UHF) magnetic resonance imaging (MRI) systems. REBCO wires are promising components for UHF-MRI magnets because of their superior superconducting and mechanical properties, which make them smaller and lighter than conventional ones. Moreover, REBCO magnets can be cooled by the conduction-cooling method, making liquid helium unnecessary. In the past two years, some test coils and model magnets have been fabricated and tested. This year is the final year of the project. The goals of the project are: (1) to generate a 9.4 T magnetic field with a small test coil, (2) to generate a homogeneous magnetic field in a 200 mm diameter spherical volume with a 1.5 T model magnet, and (3) to perform imaging with the 1.5 T model magnet. In this paper, the progress of this R&D is described. The knowledge gained through these R&D results will be reflected in the design of 9.4 T MRI magnets for brain and whole body imaging.

Ultra-high strain in epitaxial silicon carbide nanostructures utilizing residual stress amplification

NASA Astrophysics Data System (ADS)

Phan, Hoang-Phuong; Nguyen, Tuan-Khoa; Dinh, Toan; Ina, Ginnosuke; Kermany, Atieh Ranjbar; Qamar, Afzaal; Han, Jisheng; Namazu, Takahiro; Maeda, Ryutaro; Dao, Dzung Viet; Nguyen, Nam-Trung

2017-04-01

Strain engineering has attracted great attention, particularly for epitaxial films grown on a different substrate. Residual strains of SiC have been widely employed to form ultra-high frequency and high Q factor resonators. However, to date, the highest residual strain of SiC was reported to be limited to approximately 0.6%. Large strains induced into SiC could lead to several interesting physical phenomena, as well as significant improvement of resonant frequencies. We report an unprecedented nanostrain-amplifier structure with an ultra-high residual strain up to 8% utilizing the natural residual stress between epitaxial 3C-SiC and Si. In addition, the applied strain can be tuned by changing the dimensions of the amplifier structure. The possibility of introducing such a controllable and ultra-high strain will open the door to investigating the physics of SiC in large strain regimes and the development of ultra sensitive mechanical sensors.

Fringing-field dielectrophoretic assembly of ultrahigh-density semiconducting nanotube arrays with a self-limited pitch

NASA Astrophysics Data System (ADS)

Cao, Qing; Han, Shu-Jen; Tulevski, George S.

2014-09-01

One key challenge of realizing practical high-performance electronic devices based on single-walled carbon nanotubes is to produce electronically pure nanotube arrays with both a minuscule and uniform inter-tube pitch for sufficient device-packing density and homogeneity. Here we develop a method in which the alternating voltage-fringing electric field formed between surface microelectrodes and the substrate is utilized to assemble semiconducting nanotubes into well-aligned, ultrahigh-density and submonolayered arrays, with a consistent pitch as small as 21±6 nm determined by a self-limiting mechanism, based on the unique field focusing and screening effects of the fringing field. Field-effect transistors based on such nanotube arrays exhibit record high device transconductance (>50 μS μm-1) and decent on current per nanotube (~1 μA per tube) together with high on/off ratios at a drain bias of -1 V.

Dielectric waveguides for ultrahigh field magnetic resonance imaging.

PubMed

Bluemink, Johanna J; Raaijmakers, Alexander J E; Koning, Wouter; Andreychenko, Anna; Rivera, Debra S; Luijten, Peter R; Klomp, Dennis W J; van den Berg, Cornelis A T

2016-10-01

The design of RF coils for MRI transmit becomes increasingly challenging at high frequencies required for MRI at 7T and above. Our goal is to show a proof of principle of a new type of transmit coil for higher field strengths. We demonstrate an alternative transmit coil design based on dielectric waveguide principles which transfers energy via evanescent wave coupling. The operating principles and conditions are explored by simulations. The waveguide is applied for in vivo imaging at 7T. The waveguide can be an efficient transmit coil when four conditions are fulfilled: (1) the waveguide should be operated just above the cutoff frequency of the lowest order transverse electric mode, (2) the waveguide should not operate at a frequency where the wavelength fits an integer number of times in the waveguide length and standing wave patterns become very prominent, (3) for homogeneous excitation, the waveguide should be bent around the object, and (4) there should be an air gap between the waveguide and the object. By choosing the dielectric and the dimensions adequately, the dielectric waveguide couples the magnetic field efficiently into the body. The waveguide can be redesigned for higher frequencies by simple adaptations and may be a promising transmit alternative. Magn Reson Med 76:1314-1324, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Wideband spectrum analysis of ultra-high frequency radio-wave signals due to advanced one-phonon non-collinear anomalous light scattering.

PubMed

Shcherbakov, Alexandre S; Arellanes, Adan Omar

2017-04-20

We present a principally new acousto-optical cell providing an advanced wideband spectrum analysis of ultra-high frequency radio-wave signals. For the first time, we apply a recently developed approach with the tilt angle to a one-phonon non-collinear anomalous light scattering. In contrast to earlier cases, now one can exploit a regime with the fixed optical wavelength for processing a great number of acoustic frequencies simultaneously in the linear regime. The chosen rutile-crystal combines a moderate acoustic velocity with low acoustic attenuation and allows us wide-band data processing within GHz-frequency acoustic waves. We have created and experimentally tested a 6-cm aperture rutile-made acousto-optical cell providing the central frequency 2.0 GHz, frequency bandwidth ∼0.52  GHz with the frequency resolution about 68.3 kHz, and ∼7620 resolvable spots. A similar cell permits designing an advanced ultra-high-frequency arm within a recently developed multi-band radio-wave acousto-optical spectrometer for astrophysical studies. This spectrometer is intended to operate with a few parallel optical arms for processing the multi-frequency data flows within astrophysical observations. Keeping all the instrument's advantages of the previous schematic arrangement, now one can create the highest-frequency arm using the developed rutile-based acousto-optical cell. It permits optimizing the performances inherent in that arm via regulation of both the central frequency and the frequency bandwidth for spectrum analysis.

Rapid brain MRI acquisition techniques at ultra-high fields

PubMed Central

Setsompop, Kawin; Feinberg, David A.; Polimeni, Jonathan R.

2017-01-01

Ultra-high-field MRI provides large increases in signal-to-noise ratio as well as enhancement of several contrast mechanisms in both structural and functional imaging. Combined, these gains result in a substantial boost in contrast-to-noise ratio that can be exploited for higher spatial resolution imaging to extract finer-scale information about the brain. With increased spatial resolution, however, is a concurrent increased image encoding burden that can cause unacceptably long scan times for structural imaging and slow temporal sampling of the hemodynamic response in functional MRI—particularly when whole-brain imaging is desired. To address this issue, new directions of imaging technology development—such as the move from conventional 2D slice-by-slice imaging to more efficient Simultaneous MultiSlice (SMS) or MultiBand imaging (which can be viewed as “pseudo-3D” encoding) as well as full 3D imaging—have provided dramatic improvements in acquisition speed. Such imaging paradigms provide higher SNR efficiency as well as improved encoding efficiency. Moreover, SMS and 3D imaging can make better use of coil sensitivity information in multi-channel receiver arrays used for parallel imaging acquisitions through controlled aliasing in multiple spatial directions. This has enabled unprecedented acceleration factors of an order of magnitude or higher in these imaging acquisition schemes, with low image artifact levels and high SNR. Here we review the latest developments of SMS and 3D imaging methods and related technologies at ultra-high field for rapid high-resolution functional and structural imaging of the brain. PMID:26835884

Texture analysis of ultrahigh field T2*-weighted MR images of the brain: application to Huntington's disease.

PubMed

Doan, Nhat Trung; van den Bogaard, Simon J A; Dumas, Eve M; Webb, Andrew G; van Buchem, Mark A; Roos, Raymund A C; van der Grond, Jeroen; Reiber, Johan H C; Milles, Julien

2014-03-01

To develop a framework for quantitative detection of between-group textural differences in ultrahigh field T2*-weighted MR images of the brain. MR images were acquired using a three-dimensional (3D) T2*-weighted gradient echo sequence on a 7 Tesla MRI system. The phase images were high-pass filtered to remove phase wraps. Thirteen textural features were computed for both the magnitude and phase images of a region of interest based on 3D Gray-Level Co-occurrence Matrix, and subsequently evaluated to detect between-group differences using a Mann-Whitney U-test. We applied the framework to study textural differences in subcortical structures between premanifest Huntington's disease (HD), manifest HD patients, and controls. In premanifest HD, four phase-based features showed a difference in the caudate nucleus. In manifest HD, 7 magnitude-based features showed a difference in the pallidum, 6 phase-based features in the caudate nucleus, and 10 phase-based features in the putamen. After multiple comparison correction, significant differences were shown in the putamen in manifest HD by two phase-based features (both adjusted P values=0.04). This study provides the first evidence of textural heterogeneity of subcortical structures in HD. Texture analysis of ultrahigh field T2*-weighted MR images can be useful for noninvasive monitoring of neurodegenerative diseases. Copyright © 2013 Wiley Periodicals, Inc.

Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model.

PubMed

Mori, Yuki; Murakami, Masaaki; Arima, Yasunobu; Zhu, Dasong; Terayama, Yasuo; Komai, Yutaka; Nakatsuji, Yuji; Kamimura, Daisuke; Yoshioka, Yoshichika

2014-02-01

Magnetic resonance imaging (MRI) is widely employed for the diagnosis of multiple sclerosis (MS). However, sometimes, the lesions found by MRI do not correlate with the neurological impairments observed in MS patients. We recently showed autoreactive T cells accumulate in the fifth lumbar cord (L5) to pass the blood-brain barrier and cause inflammation in the central nervous system of experimental autoimmune encephalomyelitis (EAE) mice, an MS model. We here investigated this early event using ultrahigh-field MRI. T2-weighted image signals, which conform to the water content, increased in L4 and L5 during the development of EAE. At the same time, the sizes of L4 and L5 changed. Moreover, angiographic images of MRI showed branch positions of the blood vessels in the lower lumbar cords were significantly altered. Interestingly, EAE mice showed occluded and thickened vessels, particularly during the peak phase, followed by reperfusion in the remission phase. Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events. These results suggest that inflammation-mediated alterations in the lower lumbar cord change the homeostasis of the spinal cord and demonstrate that ultrahigh-field MRI enables the detection of previously invisible pathological alterations in EAE.

Low frequency electric and magnetic fields

NASA Technical Reports Server (NTRS)

Spaniol, Craig

1989-01-01

Following preliminary investigations of the low frequency electric and magnetic fields that may exists in the Earth-ionospheric cavity, measurements were taken with state-of-the art spectrum analyzers. As a follow up to this activity, an investigation was initiated to determine sources and values for possible low frequency signal that would appear in the cavity. The lowest cavity resonance is estimated at about 8 Hz, but lower frequencies may be an important component of our electromagnetic environment. The potential field frequencies produced by the electron were investigated by a classical model that included possible cross coupling of the electric and gravitation fields. During this work, an interesting relationship was found that related the high frequency charge field with the extremely low frequency of the gravitation field. The results of numerical calculations were surprisingly accurate and this area of investigation is continuing. The work toward continued development of a standardized monitoring facility is continuing with the potential of installing the prototype at West Virginia State College early in 1990. This installation would be capable of real time monitoring of ELF signals in the Earth-ionoshpere cavity and would provide some directional information. A high gain, low noise, 1/f frequency corrected preamplifier was designed and tested for the ferrite core magnetic sensor. The potential application of a super conducting sensor for the ELF magnetic field detection is under investigation. It is hoped that a fully operational monitoring network could pinpoint the location of ELF signal sources and provide new information on where these signals originate and what causes them, assuming that they are natural in origin.

A search for ultrahigh-energy neutrinos and measurement of cosmic ray radio emission with the Antarctic Impulsive Transient Antenna

NASA Astrophysics Data System (ADS)

Hoover, Stephen Lam Douglas

2010-11-01

New astronomical messengers may reveal unexpected aspects of the Universe and have often provided a unique source of fresh physical insights. Neutrinos are a promising new messenger particle, capable of carrying information from otherwise inaccessible sources. The ANtarctic Impulsive Transient Antenna (ANITA) seeks to make the first detection of an ultrahigh-energy (E > 1018 eV) neutrino flux. Such a neutrino flux almost certainly exists, produced in interactions of ultrahigh-energy cosmic rays with photons from the cosmic microwave background. ANITA is a balloon payload which monitors large volumes of the Antarctic ice sheet from an altitude of 38 km. An ultrahigh-energy neutrino which interacts in the ice sheet will produce a particle shower which will coherently radiate Cherenkov radiation in radio wavelengths (<3 GHz). Antennas on the balloon payload can then detect the resulting impulsive radio signal. The full ANITA flew for the first time from 15 December 2006 to 19 January 2007. In this dissertation, I will describe the ground calibration system used to transmit calibration signals to the payload in-flight. I will then describe techniques for analysis of ANITA data and give limits on the ultrahigh-energy neutrino flux implied by the null result of that analysis. Finally, I will demonstrate that ANITA is also sensitive to ultrahigh-energy cosmic rays and show the detection of 16 ultrahigh-energy cosmic-ray events during ANITA's first flight. This constitutes the highest frequency and widest bandwidth radio observations of cosmic-ray emission to date I show the average waveform and spectrum of these events and describe their polarization properties, which are strongly correlated with the geomagnetic field.

MRI of the Musculoskeletal System: Advanced Applications using High and Ultrahigh Field MRI.

PubMed

Alizai, Hamza; Chang, Gregory; Regatte, Ravinder R

2015-09-01

In vivo MRI has revolutionized the diagnosis and treatment of musculoskeletal disorders over the past 3 decades. Traditionally performed at 1.5 T, MRI at higher field strengths offers several advantages over lower field strengths including increased signal-to-noise ratio, higher spatial resolution, improved spectral resolution for spectroscopy, improved sensitivity for X-nucleus imaging, and decreased image acquisition times. However, the physics of imaging at higher field strengths also presents technical challenges. These include B0 and B1+ field inhomogeneity, design and construction of dedicated radiofrequency (RF) coils for use at high field, increased chemical shift and susceptibility artifacts, increased RF energy deposition (specific absorption rate), increased metal artifacts, and changes in relaxation times compared with the lower field scanners. These challenges were overcome in optimizing high-field (HF) (3 T) MRI over a decade ago. HF MRI systems have since gained universal acceptance for clinical musculoskeletal imaging and have also been widely utilized for the study of musculoskeletal anatomy and physiology. Recently there has been an increasing interest in exploring musculoskeletal applications of ultrahigh field (UHF) (7 T) systems. However, technical challenges similar to those encountered when moving from 1.5 T to 3 T have to be overcome to optimize 7 T musculoskeletal imaging. In this narrative review, we discuss the many potential opportunities and technical challenges presented by the HF and UHF MRI systems. We highlight recent developments in in vivo imaging of musculoskeletal tissues that benefit most from HF imaging including cartilage, skeletal muscle, and bone. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Mapping the Ice Depth of Europa with Ultrahigh Energy Particles

NASA Astrophysics Data System (ADS)

Romero-Wolf, A.; Naudet, C. J.

2012-12-01

There has been recent interest in applying radio emission of ultra-high energy neutrinos interacting in the ice of Europa. The idea was first described by Gorham (2004)[1] in the context of ultra-high energy particle detection. Shoji, Kurita, and Tanaka (2011)[2] proposed a technique for measuring ice depth using the radio intensity distribution of radio impulses emitted by interactions deep in the Europan ice. Miller, Schaefer, and Sequeira (2012)[3] follow up this study with a simulation of a radio detector mission to constrain the ice depth of Europa. The radio signal results from an effect proposed by Askar'yan (1962)[4] where the particle shower induced by the neutrino interaction accumulates a charge excess traveling faster than the speed of light in the medium and produces a coherent Cherenkov pulse at radio frequencies. We evaluate the feasibility of such a mission given the current state of knowledge of ultra-high energy particle detection and radio pulse production. References [1] Gorham (2004), Planet-sized Detectors for Ultra-high Energy Neutrinos & Cosmic Rays, NASA Advanced Planning Office's Capability Roadmap Public Workshop, Nov. 30, 2004, astro-ph/0411510 [2] Shoji, Kurita, and Tanaka (2011), Constraint of Europan ice thickness by measuring electromagnetic emissions induced by neutrino interaction, Geophysical Research Letters, 38, L08202 [3] Miller, Shaefer, Sequeira, PRIDE (Passive Radio [frequency] Ice Depth Experiment): An instrument to passively measure ice depth from a Europan orbiter using neutrinos, Icarus 220 877-888 [4] Askar'yan (1962), Excess negative charge of an electron photon shower and its coherent radiation originating from it. Radio recording of showers under the ground and on the Moon, Sov. Phys. JETP, 14, 441-443.

Integration of ultra-high field MRI and histology for connectome based research of brain disorders

PubMed Central

Yang, Shan; Yang, Zhengyi; Fischer, Karin; Zhong, Kai; Stadler, Jörg; Godenschweger, Frank; Steiner, Johann; Heinze, Hans-Jochen; Bernstein, Hans-Gert; Bogerts, Bernhard; Mawrin, Christian; Reutens, David C.; Speck, Oliver; Walter, Martin

2013-01-01

Ultra-high field magnetic resonance imaging (MRI) became increasingly relevant for in vivo neuroscientific research because of improved spatial resolutions. However, this is still the unchallenged domain of histological studies, which long played an important role in the investigation of neuropsychiatric disorders. While the field of biological psychiatry strongly advanced on macroscopic levels, current developments are rediscovering the richness of immunohistological information when attempting a multi-level systematic approach to brain function and dysfunction. For most studies, histology sections lost information on three-dimensional reconstructions. Translating histological sections to 3D-volumes would thus not only allow for multi-stain and multi-subject alignment in post mortem data, but also provide a crucial step in big data initiatives involving the network analyses currently performed with in vivo MRI. We therefore investigated potential pitfalls during integration of MR and histological information where no additional blockface information is available. We demonstrated that strengths and requirements from both methods can be effectively combined at a spatial resolution of 200 μm. However, the success of this approach is heavily dependent on choices of hardware, sequence and reconstruction. We provide a fully automated pipeline that optimizes histological 3D reconstructions, providing a potentially powerful solution not only for primary human post mortem research institutions in neuropsychiatric research, but also to help alleviate the massive workloads in neuroanatomical atlas initiatives. We further demonstrate (for the first time) the feasibility and quality of ultra-high spatial resolution (150 μm isotopic) imaging of the entire human brain MRI at 7T, offering new opportunities for analyses on MR-derived information. PMID:24098272

Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review.

PubMed

Henning, Anke

2018-03-01

Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more than 20 metabolites and compounds in the central nervous system of humans. The aim of this review is to give a comprehensive overview about the advantages, challenges and advances of ultra-high field MRS with regard to methodological development, discoveries and applications from its beginnings around 15 years ago up to the current state. The review is limited to human brain and spinal cord application at field strength of 7T and 9.4T and includes all relevant nuclei ( 1 H, 31 P, 13 C). Copyright © 2017 Elsevier Inc. All rights reserved.

Study of cavity type antenna structure of large-area 915 MHz ultra-high frequency wave plasma device based on three-dimensional finite difference time-domain analysis

NASA Astrophysics Data System (ADS)

Chang, Xijiang; Kunii, Kazuki; Liang, Rongqing; Nagatsu, Masaaki

2013-11-01

A large-area planar plasma source with a resonant cavity type launcher driven by a 915 MHz ultra-high frequency wave was developed. Theoretical analysis with the three-dimensional finite difference time-domain simulation was carried out to determine the optimized launcher structure by analyzing the resonant transverse magnetic mode in the resonant cavity. Numerical result expects that the resonant electric field distribution inside the cavity dominantly consists of the TM410 mode. The resonant cavity type launcher having 8 holes in an octagonal geometry was designed to fit the resonant transverse magnetic mode. Adjusting 8 hole positions of the launcher to the field pattern of the resonant TM410 mode, we found that the plasma density increased about 40%˜50% from 1.0˜1.1 × 1011 cm-3 to ˜1.5 × 1011 cm-3 at the same incident power of 2.5 kW, compared with the previous results with the launcher having 6 holes in the hexagonal geometry. It is also noted that the electron density changes almost linearly with the incident wave power without any mode jumps.

Introduction to power-frequency electric and magnetic fields.

PubMed Central

Kaune, W T

1993-01-01

This paper introduces the reader to electric and magnetic fields, particularly those fields produced by electric power systems and other sources using frequencies in the power-frequency range. Electric fields are produced by electric charges; a magnetic field also is produced if these charges are in motion. Electric fields exert forces on other charges; if in motion, these charges will experience magnetic forces. Power-frequency electric and magnetic fields induce electric currents in conducting bodies such as living organisms. The current density vector is used to describe the distribution of current within a body. The surface of the human body is an excellent shield for power-frequency electric fields, but power-frequency magnetic fields penetrate without significant attenuation; the electric fields induced inside the body by either exposure are comparable in magnitude. Electric fields induced inside a human by most environmental electric and magnetic fields appear to be small in magnitude compared to levels naturally occurring in living tissues. Detection of such fields thus would seem to require the existence of unknown biological mechanisms. Complete characterization of a power-frequency field requires measurement of the magnitudes and electrical phases of the fundamental and harmonic amplitudes of its three vector components. Most available instrumentation measures only a small subset, or some weighted average, of these quantities. Hand-held survey meters have been used widely to measure power-frequency electric and magnetic fields. Automated data-acquisition systems have come into use more recently to make electric- and magnetic-field recordings, covering periods of hours to days, in residences and other environments.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8206045

Measurement of ciliary beat frequency using ultra-high resolution optical coherence tomography

NASA Astrophysics Data System (ADS)

Chen, Jason J.; Jing, Joseph C.; Su, Erica; Badger, Christopher; Coughlan, Carolyn A.; Chen, Zhongping; Wong, Brian J. F.

2016-02-01

Ciliated epithelial cells populate up to 80% of the surface area of the human airway and are responsible for mucociliary transport, which is the key protective mechanism that provides the first line of defense in the respiratory tract. Cilia beat in a rhythmic pattern and may be easily affected by allergens, pollutants, and pathogens, altering ciliary beat frequency (CBF) subsequently. Diseases including cystic fibrosis, chronic obstructive pulmonary disease, and primary ciliary dyskinesia may also decrease CBF. CBF is therefore a critical component of respiratory health. The current clinical method of measuring CBF is phase-contrast microscopy, which involves a tissue biopsy obtained via brushing of the nasal cavity. While this method is minimally invasive, the tissue sample must be oriented to display its profile view, making the visualization of a single layer of cilia challenging. In addition, the conventional method requires subjective analysis of CBF, e.g., manually counting by visual inspection. On the contrary, optical coherence tomography (OCT) has been used to study the retina in ophthalmology as well as vasculature in cardiology, and offers higher resolution than conventional computed tomography and magnetic resonance imaging. Based on this technology, our lab specifically developed an ultra-high resolution OCT system to image the microstructure of the ciliated epithelial cells. Doppler analysis was also performed to determine CBF. Lastly, we also developed a program that utilizes fast Fourier transform to determine CBF under phase-contrast microscopy, providing a more objective method compared to the current method.

Sterilization of liquid foods by pulsed electric fields-an innovative ultra-high temperature process.

PubMed

Reineke, Kai; Schottroff, Felix; Meneses, Nicolas; Knorr, Dietrich

2015-01-01

The intention of this study was to investigate the inactivation of endospores by a combined thermal and pulsed electric field (PEF) treatment. Therefore, self-cultivated spores of Bacillus subtilis and commercial Geobacillus stearothermophilus spores with certified heat resistance were utilized. Spores of both strains were suspended in saline water (5.3 mS cm(-1)), skim milk (0.3% fat; 5.3 mS cm(-1)) and fresh prepared carrot juice (7.73 mS cm(-1)). The combination of moderate preheating (70-90°C) and an insulated PEF-chamber, combined with a holding tube (65 cm) and a heat exchanger for cooling, enabled a rapid heat up to 105-140°C (measured above the PEF chamber) within 92.2-368.9 μs. To compare the PEF process with a pure thermal inactivation, each spore suspension was heat treated in thin glass capillaries and D-values from 90 to 130°C and its corresponding z-values were calculated. For a comparison of the inactivation data, F-values for the temperature fields of both processes were calculated by using computational fluid dynamics (CFD). A preheating of saline water to 70°C with a flow rate of 5 l h(-1), a frequency of 150 Hz and an energy input of 226.5 kJ kg(-1), resulted in a measured outlet temperature of 117°C and a 4.67 log10 inactivation of B. subtilis. The thermal process with identical F-value caused only a 3.71 log10 inactivation. This synergism of moderate preheating and PEF was even more pronounced for G. stearothermophilus spores in saline water. A preheating to 95°C and an energy input of 144 kJ kg(-1) resulted in an outlet temperature of 126°C and a 3.28 log10 inactivation, whereas nearly no inactivation (0.2 log10) was achieved during the thermal treatment. Hence, the PEF technology was evaluated as an alternative ultra-high temperature process. However, for an industrial scale application of this process for sterilization, optimization of the treatment chamber design is needed to reduce the occurring inhomogeneous temperature fields.

A graphene based frequency quadrupler

NASA Astrophysics Data System (ADS)

Cheng, Chuantong; Huang, Beiju; Mao, Xurui; Zhang, Zanyun; Zhang, Zan; Geng, Zhaoxin; Xue, Ping; Chen, Hongda

2017-04-01

Benefit from exceptional electrical transport properties, graphene receives worldwide attentions, especially in the domain of high frequency electronics. Due to absence of effective bandgap causing off-state the device, graphene material is extraordinarily suitable for analog circuits rather than digital applications. With this unique ambipolar behavior, graphene can be exploited and utilized to achieve high performance for frequency multipliers. Here, dual-gated graphene field-effect transistors have been firstly used to achieve frequency quadrupling. Two Dirac points in the transfer curves of the designed GFETs can be observed by tuning top-gate voltages, which is essential to generate the fourth harmonic. By applying 200 kHz sinusoid input, arround 50% of the output signal radio frequency power is concentrated at the desired frequency of 800 kHz. Additionally, in suitable operation areas, our devices can work as high performance frequency doublers and frequency triplers. Considered both simple device structure and potential superhigh carrier mobility of graphene material, graphene-based frequency quadruplers may have lots of superiorities in regards to ultrahigh frequency electronic applications in near future. Moreover, versatility of carbon material system is far-reaching for realization of complementary metal-oxide-semiconductor compatible electrically active devices.

An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography.

PubMed

Glover, Paul M; Watkins, Roger H; O'Neill, George C; Ackerley, Rochelle; Sanchez-Panchuelo, Rosa; McGlone, Francis; Brookes, Matthew J; Wessberg, Johan; Francis, Susan T

2017-10-01

Intra-neural microstimulation (INMS) is a technique that allows the precise delivery of low-current electrical pulses into human peripheral nerves. Single unit INMS can be used to stimulate individual afferent nerve fibres during microneurography. Combining this with neuroimaging allows the unique monitoring of central nervous system activation in response to unitary, controlled tactile input, with functional magnetic resonance imaging (fMRI) providing exquisite spatial localisation of brain activity and magnetoencephalography (MEG) high temporal resolution. INMS systems suitable for use within electrophysiology laboratories have been available for many years. We describe an INMS system specifically designed to provide compatibility with both ultra-high field (7T) fMRI and MEG. Numerous technical and safety issues are addressed. The system is fully analogue, allowing for arbitrary frequency and amplitude INMS stimulation. Unitary recordings obtained within both the MRI and MEG screened-room environments are comparable with those obtained in 'clean' electrophysiology recording environments. Single unit INMS (current <7μA, 200μs pulses) of individual mechanoreceptive afferents produces appropriate and robust responses during fMRI and MEG. This custom-built MRI- and MEG-compatible stimulator overcomes issues with existing INMS approaches; it allows well-controlled switching between recording and stimulus mode, prevents electrical shocks because of long cable lengths, permits unlimited patterns of stimulation, and provides a system with improved work-flow and participant comfort. We demonstrate that the requirements for an INMS-integrated system, which can be used with both fMRI and MEG imaging systems, have been fully met. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

Impact on storage quality of red blood cells and platelets by ultrahigh-frequency radiofrequency identification tags.

PubMed

Wang, Quan-Li; Wang, Xiao-Wei; Zhuo, Hai-Long; Shao, Chun-Yan; Wang, Jie; Wang, Hai-Ping

2013-04-01

Compared to ISBT128 code labels, radiofrequency identification (RFID) tags have incomparable advantages and gradually applied in blood management system. However, there is no global standard for the uses of RFID frequency. Even though ISBT recommended high-frequency RFID with 13.56MHz, 820- to 960-MHz ultrahigh frequency (UHF) RFID technology in many ways has even more advantages. For this reason, we studied the effect of UHF RFID tags with 820- to 960-MHz exposure on storage quality of red blood cells (RBCs) and platelets (PLTs). Thirty units of collected and prepared suspended RBCs (sRBCs) and PLTs were divided into two bags, one each for the test and control groups. The sRBCs were stored in 4±2°C refrigerator and the PLTs in a 22±2°C rocking box. The test groups were exposed to RF reader continuously during storage. Sampling at different time points and biologic changes were tested. As the extension of storage and the pH and chlorine levels in the supernatant of sRBCs were reduced, free hemoglobin, potassium, and sodium increased, but were not significant between test and control groups (p>0.05). During the storage period, the pH levels, PLT count, and PLT aggregation rate were decreased in both test and control groups, but were not significant (p>0.05). When exposed to 820- to 960-MHz RF, the biologic and biochemical indexes are not found to be exacerbated during 35 days of storage for sRBCs and 5 days for PLTs, respectively. © 2012 American Association of Blood Banks.

Tracking the unconscious generation of free decisions using ultra-high field fMRI.

PubMed

Bode, Stefan; He, Anna Hanxi; Soon, Chun Siong; Trampel, Robert; Turner, Robert; Haynes, John-Dylan

2011-01-01

Recently, we demonstrated using functional magnetic resonance imaging (fMRI) that the outcome of free decisions can be decoded from brain activity several seconds before reaching conscious awareness. Activity patterns in anterior frontopolar cortex (BA 10) were temporally the first to carry intention-related information and thus a candidate region for the unconscious generation of free decisions. In the present study, the original paradigm was replicated and multivariate pattern classification was applied to functional images of frontopolar cortex, acquired using ultra-high field fMRI at 7 Tesla. Here, we show that predictive activity patterns recorded before a decision was made became increasingly stable with increasing temporal proximity to the time point of the conscious decision. Furthermore, detailed questionnaires exploring subjects' thoughts before and during the decision confirmed that decisions were made spontaneously and subjects were unaware of the evolution of their decision outcomes. These results give further evidence that FPC stands at the top of the prefrontal executive hierarchy in the unconscious generation of free decisions.

Ultra-high quality factors in superconducting niobium cavities in ambient magnetic fields up to 190 mG

DOE PAGES

Romanenko, A.; Grassellino, A.; Crawford, A. C.; ...

2014-12-10

Ambient magnetic field, if trapped in the penetration depth, leads to the residual resistance and therefore sets the limit for the achievable quality factors in superconducting niobium resonators for particle accelerators. Here, we show that a complete expulsion of the magnetic flux can be performed and leads to: (1) record quality factors Q > 2 x 10¹¹ up to accelerating gradient of 22 MV/m; (2) Q ~ 3 x 10¹⁰ at 2 K and 16 MV/m in up to 190 mG magnetic fields. This is achieved by large thermal gradients at the normal/superconducting phase front during the cooldown. Our findingsmore » open up a way to ultra-high quality factors at low temperatures and show an alternative to the sophisticated magnetic shielding implemented in modern superconducting accelerators.« less

A graphene based frequency quadrupler

PubMed Central

Cheng, Chuantong; Huang, Beiju; Mao, Xurui; Zhang, Zanyun; Zhang, Zan; Geng, Zhaoxin; Xue, Ping; Chen, Hongda

2017-01-01

Benefit from exceptional electrical transport properties, graphene receives worldwide attentions, especially in the domain of high frequency electronics. Due to absence of effective bandgap causing off-state the device, graphene material is extraordinarily suitable for analog circuits rather than digital applications. With this unique ambipolar behavior, graphene can be exploited and utilized to achieve high performance for frequency multipliers. Here, dual-gated graphene field-effect transistors have been firstly used to achieve frequency quadrupling. Two Dirac points in the transfer curves of the designed GFETs can be observed by tuning top-gate voltages, which is essential to generate the fourth harmonic. By applying 200 kHz sinusoid input, arround 50% of the output signal radio frequency power is concentrated at the desired frequency of 800 kHz. Additionally, in suitable operation areas, our devices can work as high performance frequency doublers and frequency triplers. Considered both simple device structure and potential superhigh carrier mobility of graphene material, graphene-based frequency quadruplers may have lots of superiorities in regards to ultrahigh frequency electronic applications in near future. Moreover, versatility of carbon material system is far-reaching for realization of complementary metal-oxide-semiconductor compatible electrically active devices. PMID:28418013

Brain–heart interactions: challenges and opportunities with functional magnetic resonance imaging at ultra-high field

PubMed Central

Raven, Erika P.; Duyn, Jeff H.

2016-01-01

Magnetic resonance imaging (MRI) at ultra-high field (UHF) strengths (7 T and above) offers unique opportunities for studying the human brain with increased spatial resolution, contrast and sensitivity. However, its reliability can be compromised by factors such as head motion, image distortion and non-neural fluctuations of the functional MRI signal. The objective of this review is to provide a critical discussion of the advantages and trade-offs associated with UHF imaging, focusing on the application to studying brain–heart interactions. We describe how UHF MRI may provide contrast and resolution benefits for measuring neural activity of regions involved in the control and mediation of autonomic processes, and in delineating such regions based on anatomical MRI contrast. Limitations arising from confounding signals are discussed, including challenges with distinguishing non-neural physiological effects from the neural signals of interest that reflect cardiorespiratory function. We also consider how recently developed data analysis techniques may be applied to high-field imaging data to uncover novel information about brain–heart interactions. PMID:27044994

Brain-heart interactions: challenges and opportunities with functional magnetic resonance imaging at ultra-high field.

PubMed

Chang, Catie; Raven, Erika P; Duyn, Jeff H

2016-05-13

Magnetic resonance imaging (MRI) at ultra-high field (UHF) strengths (7 T and above) offers unique opportunities for studying the human brain with increased spatial resolution, contrast and sensitivity. However, its reliability can be compromised by factors such as head motion, image distortion and non-neural fluctuations of the functional MRI signal. The objective of this review is to provide a critical discussion of the advantages and trade-offs associated with UHF imaging, focusing on the application to studying brain-heart interactions. We describe how UHF MRI may provide contrast and resolution benefits for measuring neural activity of regions involved in the control and mediation of autonomic processes, and in delineating such regions based on anatomical MRI contrast. Limitations arising from confounding signals are discussed, including challenges with distinguishing non-neural physiological effects from the neural signals of interest that reflect cardiorespiratory function. We also consider how recently developed data analysis techniques may be applied to high-field imaging data to uncover novel information about brain-heart interactions. © 2016 The Author(s).

THE CENTAURUS A ULTRAHIGH-ENERGY COSMIC-RAY EXCESS AND THE LOCAL EXTRAGALACTIC MAGNETIC FIELD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yueksel, Hasan; Kronberg, Philipp P.; Stanev, Todor

2012-10-10

The ultrahigh-energy cosmic-ray (UHECR) anisotropies discovered by the Pierre Auger Observatory provide the potential to finally address both the particle origins and properties of the nearby extragalactic magnetic field (EGMF). We examine the implications of the excess of {approx}10{sup 20} eV events around the nearby radio galaxy Centaurus A. We find that, if Cen A is the source of these cosmic rays, the angular distribution of events constrains the EGMF strength within several Mpc of the Milky Way to {approx}> 20 nG for an assumed primary proton composition. Our conclusions suggest that either the observed excess is a statistical anomalymore » or the local EGMF is stronger than conventionally thought. We discuss several implications, including UHECR scattering from more distant sources, time delays from transient sources, and the possibility of using magnetic lensing signatures to attain tighter constraints.« less

Ultrahigh 6D-brightness electron beams for the light sources of the next generation

NASA Astrophysics Data System (ADS)

Habib, Fahim; Manahan, Grace G.; Scherkl, Paul; Heinemann, Thomas; Sheng, Z. M.; Bruhwiler, D. L.; Cary, J. R.; Rosenzweig, J. B.; Hidding, Bernhard

2017-10-01

The plasma photocathode mechanism (aka Trojan Horse) enables a path towards electron beams with nm-level normalized emittance and kA range peak currents, hence ultrahigh 5D-brightness. This ultrahigh 5D-brightness beams hold great prospects to realize laboratory scale free-electron-lasers. However, the GV/m-accelerating gradient in plasma accelerators leads to substantial energy chirp and spread. The large energy spread is a major show-stopper towards key application such as the free-electron-laser. Here we present a novel method for energy chirp compensation which takes advantage of tailored beam loading due to a second ``escort'' bunch released via plasma photocathode. The escort bunch reverses the accelerating field locally at the trapping position of the ultrahigh 5D-brightness beam. This induces a counter-clockwise rotation within the longitudinal phase space and allows to compensate the chirp completely. Analytical scaling predicts energy spread values below 0.01 percentage level. Ultrahigh 5D-brightness combined with minimized energy spread opens a path towards witness beams with unprecedented ultrahigh 6D-brightness.

REVIEWS OF TOPICAL PROBLEMS: Properties of matter in ultrahigh magnetic fields and the structure of the surface of neutron stars

NASA Astrophysics Data System (ADS)

Liberman, Mikhail A.; Johansson, B.

1995-02-01

The physical properties of atoms, molecules, and solids in ultrahigh magnetic fields B gg 109 G that are believed to exist on the surface of neutron stars are discussed. In these fields, atoms are strongly deformed and elongated along the magnetic field lines; the binding energy and ionizing energy of the atoms are substantially increased and the interatomic interaction is dramatically changed. This strongly modifies the properties of matter at the surface of magnetic neutron stars which are crucial for modelling the pulsar magnetosphere. A scenario for magnetosphere evolution is proposed which suggests free emission for a young pulsar and strong binding of the matter to the surface at a later stage. This later stage is due to strongly bound chains of alternate heavy atoms and light atoms accreted on the surface of the star.

Photonuclear interactions of ultrahigh energy cosmic rays and their astrophysical consequences

NASA Technical Reports Server (NTRS)

Puget, J. L.; Stecker, F. W.; Bredekamp, J. H.

1975-01-01

Results of detailed Monte Carlo calculations of the interaction histories of ultrahigh energy cosmic-ray nuclei with intergalactic radiation fields are presented. Estimates of these fields and empirical determinations of photonuclear cross sections are used, including multinuclear disintegrations for nuclei up to 56Fe. Intergalactic and galactic energy loss rates and nucleon loss rates for nuclei up to 56Fe are also given. Astrophysical implications are discussed in terms of expected features in the cosmic-ray spectrum between quintillion and sextillion eV for the universal and supercluster origin hypotheses. The results of these calculations indicate that ultrahigh energy cosmic rays cannot be universal in origin regardless of whether they are protons or nuclei. Both the supercluster and galactic origin hypotheses, however, are possible regardless of nuclear composition.

A diamond-based scanning probe spin sensor operating at low temperature in ultra-high vacuum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schaefer-Nolte, E.; Wrachtrup, J.; 3rd Institute of Physics and Research Center SCoPE, University Stuttgart, 70569 Stuttgart

2014-01-15

We present the design and performance of an ultra-high vacuum (UHV) low temperature scanning probe microscope employing the nitrogen-vacancy color center in diamond as an ultrasensitive magnetic field sensor. Using this center as an atomic-size scanning probe has enabled imaging of nanoscale magnetic fields and single spins under ambient conditions. In this article we describe an experimental setup to operate this sensor in a cryogenic UHV environment. This will extend the applicability to a variety of molecular systems due to the enhanced target spin lifetimes at low temperature and the controlled sample preparation under UHV conditions. The instrument combines amore » tuning-fork based atomic force microscope (AFM) with a high numeric aperture confocal microscope and the facilities for application of radio-frequency (RF) fields for spin manipulation. We verify a sample temperature of <50 K even for strong laser and RF excitation and demonstrate magnetic resonance imaging with a magnetic AFM tip.« less

Pulsed-High Field/High-Frequency EPR Spectroscopy

NASA Astrophysics Data System (ADS)

Fuhs, Michael; Moebius, Klaus

Pulsed high-field/high-frequency electron paramagnetic resonance (EPR) spectroscopy is used to disentangle many kinds of different effects often obscured in continuous wave (cw) EPR spectra at lower magnetic fields/microwave frequencies. While the high magnetic field increases the resolution of G tensors and of nuclear Larmor frequencies, the high frequencies allow for higher time resolution for molecular dynamics as well as for transient paramagnetic intermediates studied with time-resolved EPR. Pulsed EPR methods are used for example for relaxation-time studies, and pulsed Electron Nuclear DOuble Resonance (ENDOR) is used to resolve unresolved hyperfine structure hidden in inhomogeneous linewidths. In the present article we introduce the basic concepts and selected applications to structure and mobility studies on electron transfer systems, reaction centers of photosynthesis as well as biomimetic models. The article concludes with an introduction to stochastic EPR which makes use of an other concept for investigating resonance systems in order to increase the excitation bandwidth of pulsed EPR. The limited excitation bandwidth of pulses at high frequency is one of the main limitations which, so far, made Fourier transform methods hardly feasible.

Double Donut Schmidt Camera, a wide-field, large-aperture, and lightweight space telescope for the detection of ultrahigh energy cosmic rays.

PubMed

Sandri, Paolo; Mazzinghi, Piero; Da Deppo, Vania

2018-04-20

A wide-field, large-aperture, and lightweight Schmidt configuration has been studied for a space mission proposal named Extreme Universe Space Observatory free flyer (EUSO-FF). EUSO-FF will be devoted to the study of ultrahigh energy cosmic rays, i.e., with energy >5×10 19   eV, through the detection of UV fluorescence light emitted by air showers in the Earth's atmosphere. The proposed telescope has a field of view of about 50° and an entrance pupil diameter of 4.2 m. The mirror is deployable and segmented to fit the diameter of the launcher fairing; the corrector is a lightweight annular corona.

Formation of Multi-Layer Structures in Bi3Pb7 Intermetallic Compounds under an Ultra-High Gravitational Field

NASA Astrophysics Data System (ADS)

Mashimo, T.; Iguchi, Y.; Bagum, R.; Sano, T.; Sakata, O.; Ono, M.; Okayasu, S.

2008-02-01

Ultra-high gravitational field (Mega-gravity field) can promote sedimentation of atoms (diffusion) even in solids, and is expected to form a compositionally-graded structure and/or nonequilibrium phase in multi-component condensed matter. We had achieved sedimentation of substitutional solute atoms in miscible systems (Bi-Sb, In-Pb, etc.). In this study, a mega-gravity experiment at high temperature was performed on a thin-plate sample (0.7 mm in thickness) of the intermetallic compound Bi3Pb7. A visible four-layer structure was produced, which exhibited different microscopic structures. In the lowest-gravity region layer, Bi phase appeared. In the mid layers, a compositionally-graded structure was formed, with differences observed in the powder X-ray diffraction patterns. Such a multi-layer structure is expected to exhibit unique physical properties such as superconductivity.

REVIEWS OF TOPICAL PROBLEMS: Ultrahigh-energy neutrinos from astrophysical sources and superheavy particle decays

NASA Astrophysics Data System (ADS)

Ryabov, Vladimir A.

2006-09-01

Problems in the fields of neutrino astronomy and ultrahigh-energy astrophysics are reviewed. Neutrino fluxes produced in various astrophysical sources (bottom-up acceleration scenarios) and resulting from the decay of superheavy particles (top-down scenarios) are considered. Neutrino oscillation processes and the absorption and regeneration of neutrinos inside the earth are analyzed and some other factors affecting the intensity and flavor composition of astrophysical neutrino fluxes are discussed. Details of ultrahigh-energy neutrino interactions are discussed within the Standard Model, as well as using nonstandard scenarios predicting an anomalous increase in the inelastic neutrino-nucleon cross section. Ultrahigh-energy neutrino detection techniques currently in use in new-generation neutrino telescopes and cosmic ray detectors are also discussed.

The Travelling-Wave Primate System: A New Solution for Magnetic Resonance Imaging of Macaque Monkeys at 7 Tesla Ultra-High Field.

PubMed

Herrmann, Tim; Mallow, Johannes; Plaumann, Markus; Luchtmann, Michael; Stadler, Jörg; Mylius, Judith; Brosch, Michael; Bernarding, Johannes

2015-01-01

Neuroimaging of macaques at ultra-high field (UHF) is usually conducted by combining a volume coil for transmit (Tx) and a phased array coil for receive (Rx) tightly enclosing the monkey's head. Good results have been achieved using vertical or horizontal magnets with implanted or near-surface coils. An alternative and less costly approach, the travelling-wave (TW) excitation concept, may offer more flexible experimental setups on human whole-body UHF magnetic resonance imaging (MRI) systems, which are now more widely available. Goal of the study was developing and validating the TW concept for in vivo primate MRI. The TW Primate System (TWPS) uses the radio frequency shield of the gradient system of a human whole-body 7 T MRI system as a waveguide to propagate a circularly polarized B1 field represented by the TE11 mode. This mode is excited by a specifically designed 2-port patch antenna. For receive, a customized neuroimaging monkey head receive-only coil was designed. Field simulation was used for development and evaluation. Signal-to-noise ratio (SNR) was compared with data acquired with a conventional monkey volume head coil consisting of a homogeneous transmit coil and a 12-element receive coil. The TWPS offered good image homogeneity in the volume-of-interest Turbo spin echo images exhibited a high contrast, allowing a clear depiction of the cerebral anatomy. As a prerequisite for functional MRI, whole brain ultrafast echo planar images were successfully acquired. The TWPS presents a promising new approach to fMRI of macaques for research groups with access to a horizontal UHF MRI system.

The Travelling-Wave Primate System: A New Solution for Magnetic Resonance Imaging of Macaque Monkeys at 7 Tesla Ultra-High Field

PubMed Central

Herrmann, Tim; Mallow, Johannes; Plaumann, Markus; Luchtmann, Michael; Stadler, Jörg; Mylius, Judith; Brosch, Michael; Bernarding, Johannes

2015-01-01

Introduction Neuroimaging of macaques at ultra-high field (UHF) is usually conducted by combining a volume coil for transmit (Tx) and a phased array coil for receive (Rx) tightly enclosing the monkey’s head. Good results have been achieved using vertical or horizontal magnets with implanted or near-surface coils. An alternative and less costly approach, the travelling-wave (TW) excitation concept, may offer more flexible experimental setups on human whole-body UHF magnetic resonance imaging (MRI) systems, which are now more widely available. Goal of the study was developing and validating the TW concept for in vivo primate MRI. Methods The TW Primate System (TWPS) uses the radio frequency shield of the gradient system of a human whole-body 7 T MRI system as a waveguide to propagate a circularly polarized B1 field represented by the TE11 mode. This mode is excited by a specifically designed 2-port patch antenna. For receive, a customized neuroimaging monkey head receive-only coil was designed. Field simulation was used for development and evaluation. Signal-to-noise ratio (SNR) was compared with data acquired with a conventional monkey volume head coil consisting of a homogeneous transmit coil and a 12-element receive coil. Results The TWPS offered good image homogeneity in the volume-of-interest Turbo spin echo images exhibited a high contrast, allowing a clear depiction of the cerebral anatomy. As a prerequisite for functional MRI, whole brain ultrafast echo planar images were successfully acquired. Conclusion The TWPS presents a promising new approach to fMRI of macaques for research groups with access to a horizontal UHF MRI system. PMID:26066653

Photonuclear interactions of ultrahigh energy cosmic rays and their astrophysical consequences

NASA Technical Reports Server (NTRS)

Puget, J. L.; Stecker, F. W.; Bredekamp, J. H.

1976-01-01

Results are presented for detailed Monte Carlo calculations of the interaction histories of ultrahigh-energy cosmic-ray nuclei with intergalactic radiation fields, using improved estimates of these fields and empirical determinations of photonuclear cross sections, including multinuclear disintegrations for nuclei up to Fe-56. Intergalactic and galactic energy-loss rates and nucleon-loss rates for nuclei up to Fe-56 are also given. Astrophysical implications are discussed in terms of expected features in the cosmic-ray spectrum between 10 to the 18th and 10 to the 21st power eV for the universal and supercluster origin hypotheses. The results of these calculations indicate that ultrahigh-energy cosmic rays cannot be universal in origin regardless of whether they are protons or nuclei. Both the supercluster and galactic origin hypotheses, however, are possible regardless of nuclear composition.

Ultra-high vacuum compatible induction-heated rod casting furnace

NASA Astrophysics Data System (ADS)

Bauer, A.; Neubauer, A.; Münzer, W.; Regnat, A.; Benka, G.; Meven, M.; Pedersen, B.; Pfleiderer, C.

2016-06-01

We report the design of a radio-frequency induction-heated rod casting furnace that permits the preparation of polycrystalline ingots of intermetallic compounds under ultra-high vacuum compatible conditions. The central part of the system is a bespoke water-cooled Hukin crucible supporting a casting mold. Depending on the choice of the mold, typical rods have a diameter between 6 mm and 10 mm and a length up to 90 mm, suitable for single-crystal growth by means of float-zoning. The setup is all-metal sealed and may be baked out. We find that the resulting ultra-high vacuum represents an important precondition for processing compounds with high vapor pressures under a high-purity argon atmosphere up to 3 bars. Using the rod casting furnace, we succeeded to prepare large high-quality single crystals of two half-Heusler compounds, namely, the itinerant antiferromagnet CuMnSb and the half-metallic ferromagnet NiMnSb.

Ultra-high vacuum compatible induction-heated rod casting furnace.

PubMed

Bauer, A; Neubauer, A; Münzer, W; Regnat, A; Benka, G; Meven, M; Pedersen, B; Pfleiderer, C

2016-06-01

We report the design of a radio-frequency induction-heated rod casting furnace that permits the preparation of polycrystalline ingots of intermetallic compounds under ultra-high vacuum compatible conditions. The central part of the system is a bespoke water-cooled Hukin crucible supporting a casting mold. Depending on the choice of the mold, typical rods have a diameter between 6 mm and 10 mm and a length up to 90 mm, suitable for single-crystal growth by means of float-zoning. The setup is all-metal sealed and may be baked out. We find that the resulting ultra-high vacuum represents an important precondition for processing compounds with high vapor pressures under a high-purity argon atmosphere up to 3 bars. Using the rod casting furnace, we succeeded to prepare large high-quality single crystals of two half-Heusler compounds, namely, the itinerant antiferromagnet CuMnSb and the half-metallic ferromagnet NiMnSb.

Ultrahigh-Repetition Pulse Train with Absolute-Phase Control Produced by AN Adiabatic Raman Process

NASA Astrophysics Data System (ADS)

Katsuragawa, M.; Suzuki, T.; Shiraga, K.; Arakawa, M.; Onose, T.; Yokoyama, K.; Hong, F. L.; Misawa, K.

2010-02-01

We describe the generation of an ultrahigh-repetition-rate train of ultrashort pulses on the basis of an adiabatic Raman process. We also describe recent progress in studies toward the ultimate regime: realization of an ultrahigh-repetition-rate train of monocycle pulses with control of the absolute phase. We comment on the milestones expected in the near future in terms of the study of such novel light sources and the new field of optical science stimulated by their development.

Bridging ultrahigh-Q devices and photonic circuits

NASA Astrophysics Data System (ADS)

Yang, Ki Youl; Oh, Dong Yoon; Lee, Seung Hoon; Yang, Qi-Fan; Yi, Xu; Shen, Boqiang; Wang, Heming; Vahala, Kerry

2018-05-01

Optical microresonators are essential to a broad range of technologies and scientific disciplines. However, many of their applications rely on discrete devices to attain challenging combinations of ultra-low-loss performance (ultrahigh Q) and resonator design requirements. This prevents access to scalable fabrication methods for photonic integration and lithographic feature control. Indeed, finding a microfabrication bridge that connects ultrahigh-Q device functions with photonic circuits is a priority of the microcavity field. Here, an integrated resonator having a record Q factor over 200 million is presented. Its ultra-low-loss and flexible cavity design brings performance to integrated systems that has been the exclusive domain of discrete silica and crystalline microcavity devices. Two distinctly different devices are demonstrated: soliton sources with electronic repetition rates and high-coherence/low-threshold Brillouin lasers. This multi-device capability and performance from a single integrated cavity platform represents a critical advance for future photonic circuits and systems.

Development of Non-Proprietary Ultra-High Performance Concrete : Research Topic Statement

DOT National Transportation Integrated Search

2014-05-29

Ultra-high performance concrete became commercially available in the U.S. in 2000. Since then, UHPC has been actively promoted by the Federal Highway Administration. UHPC has mostly been used in the U.S. for field-cast connections of prefabricated br...

Energy deposition processes in biological tissue: nonthermal biohazards seem unlikely in the ultra-high frequency range.

PubMed

Pickard, W F; Moros, E G

2001-02-01

The prospects of ultra high frequency (UHF, 300--3000 MHz) irradiation producing a nonthermal bioeffect are considered theoretically and found to be small. First, a general formula is derived within the framework of macroscopic electrodynamics for the specific absorption rate of microwaves in a biological tissue; this involves the complex Poynting vector, the mass density of the medium, the angular frequency of the electromagnetic field, and the three complex electromagnetic constitutive parameters of the medium. In the frequency ranges used for cellular telephony and personal communication systems, this model predicts that the chief physical loss mechanism will be ionic conduction, with increasingly important contributions from dielectric relaxation as the frequency rises. However, even in a magnetite unit cell within a magnetosome the deposition rate should not exceed 1/10 k(B)T per second. This supports previous arguments for the improbability of biological effects at UHF frequencies unless a mechanism can be found for accumulating energy over time and space and focussing it. Second, three possible nonthermal accumulation mechanisms are then considered and shown to be unlikely: (i) multiphoton absorption processes; (ii) direct electric field effects on ions; (iii) cooperative effects and/or coherent excitations. Finally, it is concluded that the rate of energy deposition from a typical field and within a typical tissue is so small as to make unlikely any significant nonthermal biological effect. Copyright 2001 Wiley-Liss, Inc.

Laser beam welding of new ultra-high strength and supra-ductile steels

NASA Astrophysics Data System (ADS)

Dahmen, Martin

2015-03-01

Ultra-high strength and supra-ductile are entering fields of new applications. Those materials are excellent candidates for modern light-weight construction and functional integration. As ultra-high strength steels the stainless martensitic grade 1.4034 and the bainitic steel UNS 53835 are investigated. For the supra-ductile steels stand two high austenitic steels with 18 and 28 % manganese. As there are no processing windows an approach from the metallurgical base on is required. Adjusting the weld microstructure the Q+P and the QT steels require weld heat treatment. The HSD steel is weldable without. Due to their applications the ultra-high strength steels are welded in as-rolled and strengthened condition. Also the reaction of the weld on hot stamping is reflected for the martensitic grades. The supra-ductile steels are welded as solution annealed and work hardened by 50%. The results show the general suitability for laser beam welding.

Features of Extrusion Processing of Ultrahigh Molecular Weight Polyethylene. Experiment and Theory

NASA Astrophysics Data System (ADS)

Skul‧skii, O. I.; Slavnov, E. V.

2018-05-01

Experimental studies have been made of the permissible regimes of processing ultrahigh molecular weight polyethylene GUR 2122 with molecular mass of 4.5 million g/moles in a laboratory extruder with an auger diameter 32 mm and a ratio L/D = 20 at temperatures of 155-165oC. On the basis of rotational viscometry, the rheological properties of the melt are described. A mathematical model and a numerical method for calculating the motion of ultrahigh molecular weight polyethylene melt in the auger and in the moulding rigging are proposed. The velocity and stress fields have been determined.

Ultra-high resistive and anisotropic CoPd-CaF2 nanogranular soft magnetic films prepared by tandem-sputtering deposition

NASA Astrophysics Data System (ADS)

Naoe, Masayuki; Kobayashi, Nobukiyo; Ohnuma, Shigehiro; Iwasa, Tadayoshi; Arai, Ken-Ichi; Masumoto, Hiroshi

2015-10-01

Ultra-high resistive and anisotropic soft magnetic films for gigahertz applications are desirable to demonstrate the really practical films. Here we present a study of novel nanogranular films fabricated by tandem-sputtering deposition. Their electromagnetic properties and nanostructure have also been discussed. These films consisted of nanocrystallized CoPd alloy-granules and CaF2 matrix, and a specimen having a composition of (Co0.69Pd0.31)52-(Ca0.31F0.69)48 exhibited distinct in-plane uniaxial anisotropy after uniaxial field annealing with granule growth. Its complex permeability spectra have a ferromagnetic resonance frequency extending to the Super-High-Frequency band due to its higher anisotropy field, and its frequency response was quite well reproduced by a numerical calculation based on the Landau-Lifshitz-Gilbert equation. Furthermore, it was clarified that the CaF2-based nanogranular film exhibits a hundredfold higher electrical resistivity than conventional oxide or nitride-based films. Higher resistivity enables the film thickness to achieve a margin exceeding threefold against eddy current loss. The greater resistivity of nanogranular films is attributed to the wide energy bandgap and superior crystallinity of CaF2 matrix.

Development of ultra-high temperature material characterization capabilities using digital image correlation analysis

NASA Astrophysics Data System (ADS)

Cline, Julia Elaine

2011-12-01

Ultra-high temperature deformation measurements are required to characterize the thermo-mechanical response of material systems for thermal protection systems for aerospace applications. The use of conventional surface-contacting strain measurement techniques is not practical in elevated temperature conditions. Technological advancements in digital imaging provide impetus to measure full-field displacement and determine strain fields with sub-pixel accuracy by image processing. In this work, an Instron electromechanical axial testing machine with a custom-designed high temperature gripping mechanism is used to apply quasi-static tensile loads to graphite specimens heated to 2000°F (1093°C). Specimen heating via Joule effect is achieved and maintained with a custom-designed temperature control system. Images are captured at monotonically increasing load levels throughout the test duration using an 18 megapixel Canon EOS Rebel T2i digital camera with a modified Schneider Kreutznach telecentric lens and a combination of blue light illumination and narrow band-pass filter system. Images are processed using an open-source Matlab-based digital image correlation (DIC) code. Validation of source code is performed using Mathematica generated images with specified known displacement fields in order to gain confidence in accurate software tracking capabilities. Room temperature results are compared with extensometer readings. Ultra-high temperature strain measurements for graphite are obtained at low load levels, demonstrating the potential for non-contacting digital image correlation techniques to accurately determine full-field strain measurements at ultra-high temperature. Recommendations are given to improve the experimental set-up to achieve displacement field measurements accurate to 1/10 pixel and strain field accuracy of less than 2%.

High-frequency electric field measurement using a toroidal antenna

DOEpatents

Lee, Ki Ha

2002-01-01

A simple and compact method and apparatus for detecting high frequency electric fields, particularly in the frequency range of 1 MHz to 100 MHz, uses a compact toroidal antenna. For typical geophysical applications the sensor will be used to detect electric fields for a wide range of spectrum starting from about 1 MHz, in particular in the frequency range between 1 to 100 MHz, to detect small objects in the upper few meters of the ground. Time-varying magnetic fields associated with time-varying electric fields induce an emf (voltage) in a toroidal coil. The electric field at the center of (and perpendicular to the plane of) the toroid is shown to be linearly related to this induced voltage. By measuring the voltage across a toroidal coil one can easily and accurately determine the electric field.

Study of ultra-high energy emission from Cygnus X-3 and Hercules X-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dingus, B.L.

1988-11-01

The CYGNUS experiment, consisting of an extensive air shower detector and a muon detector, was built at Los Alamos, New Mexico (latitude 36 N, longitude 107W, altitude 2310 meters), to search for point sources of ultra-high energy (>10/sup 14/ eV) particles. These particles must be long-lived neutral particles because of the long source distances and the presence of the intragalactic magnetic field. Gamma rays are the most likely candidates because of the short neutron lifetime and the small neutrino cross section. Therefore, the muon content of the source showers is examined to determine if these events are muon poor asmore » is expected for gamma-initiated showers. The data set from April 1986 to July 1987 is searched for continual emission from Cygnus X-3 and Hercules X-1, and an upper bound to flux is determined for both sources. The flux limit for Cygnus X-3, 2.0 /times/ 10/sup /minus/13/ cm/sup /minus/2/ sec/sup /minus/1/ above 50 TeV, is lower than previous ultra-high energy observations. Hercules X-1 has never been observed continually at ultra-high energies. Cygnus X-3 is observed for a shorter interval of time, beginning on 17 April 1986 and ending 1 June 1986. There is one chance in 300 that the observation is due to a random fluctuation. The signal is correlated with the 4.8 hour orbital period, and the muon content of the showers in the signal is inconsistent with the conventional prediction of gamma- initiated showers. An episodic signal is also reported for Hercules X-1, and it consists of two bursts of less than one hour duration on 24 July 1986. The probability is one chance in 12,000 that this observation is not associated with Hercules X-1. The signal is pulsed at frequency near, but significantly different from, the x-ray pulsar frequency. The muon content of the signal showers is also anomalous, assuming the showers are initiated by gamma rays. 62 refs., 60 figs.« less

High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength.

PubMed

Henley, W Hampton; He, Yan; Mellors, J Scott; Batz, Nicholas G; Ramsey, J Michael; Jorgenson, James W

2017-11-10

Ultra-high voltage capillary electrophoresis with high electric field strength has been applied to the separation of the charge variants, drug conjugates, and disulfide isomers of monoclonal antibodies. Samples composed of many closely related species are difficult to resolve and quantify using traditional analytical instrumentation. High performance instrumentation can often save considerable time and effort otherwise spent on extensive method development. Ideally, the resolution obtained for a given CE buffer system scales with the square root of the applied voltage. Currently available commercial CE instrumentation is limited to an applied voltage of approximately 30kV and a maximum electric field strength of 1kV/cm due to design limitations. The instrumentation described here is capable of safely applying potentials of at least 120kV with electric field strengths over 2000V/cm, potentially doubling the resolution of the best conventional CE buffer/capillary systems while decreasing analysis time in some applications. Separations of these complex mixtures using this new instrumentation demonstrate the potential of ultra-high voltage CE to identify the presence of previously unresolved components and to reduce analysis time for complex mixtures of antibody variants and drug conjugates. Copyright © 2017 Elsevier B.V. All rights reserved.

Study of cavity type antenna structure of large-area 915 MHz ultra-high frequency wave plasma device based on three-dimensional finite difference time-domain analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Xijiang; Graduate School of Science and Engineering, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561; Kunii, Kazuki

2013-11-14

A large-area planar plasma source with a resonant cavity type launcher driven by a 915 MHz ultra-high frequency wave was developed. Theoretical analysis with the three-dimensional finite difference time-domain simulation was carried out to determine the optimized launcher structure by analyzing the resonant transverse magnetic mode in the resonant cavity. Numerical result expects that the resonant electric field distribution inside the cavity dominantly consists of the TM{sub 410} mode. The resonant cavity type launcher having 8 holes in an octagonal geometry was designed to fit the resonant transverse magnetic mode. Adjusting 8 hole positions of the launcher to the fieldmore » pattern of the resonant TM{sub 410} mode, we found that the plasma density increased about 40%∼50% from 1.0∼1.1 × 10{sup 11} cm{sup −3} to ∼1.5 × 10{sup 11} cm{sup −3} at the same incident power of 2.5 kW, compared with the previous results with the launcher having 6 holes in the hexagonal geometry. It is also noted that the electron density changes almost linearly with the incident wave power without any mode jumps.« less

Real Space Imaging of the Microscopic Origins of the Ultrahigh Dielectric Constant in Polycrystalline CaCu 3Ti 4O 12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinin, Sergei V; Shin, Junsoo; Veith, Gabriel M

2005-01-01

The origins of an ultrahigh dielectric constant in polycrystalline CaCu{sub 3}Ti{sub 4}O{sub 12} (CCTO) were studied using the combination of impedance spectroscopy, electron microscopy, and scanning probe microscopy (SPM). Impedance spectra indicate that the transport properties in the 0.1 Hz-1 MHz frequency range are dominated by a single parallel resistive-capacitive (RC) element with a characteristic relaxation frequency of 16 Hz. dc potential distributions measurements by SPM illustrate that significant potential drops occur at the grain boundaries, which thus can be unambiguously identified as the dominant RC element. High frequency ac amplitude and phase distributions illustrate very weak grain boundary contrastmore » in SPM, indicative of strong capacitive coupling across the interfaces. These results demonstrate that the ultrahigh dielectric constant reported for polycrystalline CCTO materials is related to grain-boundary behavior.« less

Choriocapillaris and Choroidal Microvasculature Imaging with Ultrahigh Speed OCT Angiography

PubMed Central

Choi, WooJhon; Mohler, Kathrin J.; Potsaid, Benjamin; Lu, Chen D.; Liu, Jonathan J.; Jayaraman, Vijaysekhar; Cable, Alex E.; Duker, Jay S.; Huber, Robert; Fujimoto, James G.

2013-01-01

We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a 400 kHz A-scan rate is developed for three-dimensional ultrahigh speed imaging of the posterior eye. OCT angiography is used to image three-dimensional vascular structure without the need for exogenous fluorophores by detecting erythrocyte motion contrast between OCT intensity cross-sectional images acquired rapidly and repeatedly from the same location on the retina. En face OCT angiograms of the choriocapillaris and choroidal vasculature are visualized by acquiring cross-sectional OCT angiograms volumetrically via raster scanning and segmenting the three-dimensional angiographic data at multiple depths below the retinal pigment epithelium (RPE). Fine microvasculature of the choriocapillaris, as well as tightly packed networks of feeding arterioles and draining venules, can be visualized at different en face depths. Panoramic ultra-wide field stitched OCT angiograms of the choriocapillaris spanning ∼32 mm on the retina show distinct vascular structures at different fundus locations. Isolated smaller fields at the central fovea and ∼6 mm nasal to the fovea at the depths of the choriocapillaris and Sattler's layer show vasculature structures consistent with established architectural morphology from histological and electron micrograph corrosion casting studies. Choriocapillaris imaging was performed in eight healthy volunteers with OCT angiograms successfully acquired from all subjects. These results demonstrate the feasibility of ultrahigh speed OCT for in vivo dye-free choriocapillaris and choroidal vasculature imaging, in addition to conventional structural imaging. PMID:24349078

Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography.

PubMed

Choi, WooJhon; Mohler, Kathrin J; Potsaid, Benjamin; Lu, Chen D; Liu, Jonathan J; Jayaraman, Vijaysekhar; Cable, Alex E; Duker, Jay S; Huber, Robert; Fujimoto, James G

2013-01-01

We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a 400 kHz A-scan rate is developed for three-dimensional ultrahigh speed imaging of the posterior eye. OCT angiography is used to image three-dimensional vascular structure without the need for exogenous fluorophores by detecting erythrocyte motion contrast between OCT intensity cross-sectional images acquired rapidly and repeatedly from the same location on the retina. En face OCT angiograms of the choriocapillaris and choroidal vasculature are visualized by acquiring cross-sectional OCT angiograms volumetrically via raster scanning and segmenting the three-dimensional angiographic data at multiple depths below the retinal pigment epithelium (RPE). Fine microvasculature of the choriocapillaris, as well as tightly packed networks of feeding arterioles and draining venules, can be visualized at different en face depths. Panoramic ultra-wide field stitched OCT angiograms of the choriocapillaris spanning ∼32 mm on the retina show distinct vascular structures at different fundus locations. Isolated smaller fields at the central fovea and ∼6 mm nasal to the fovea at the depths of the choriocapillaris and Sattler's layer show vasculature structures consistent with established architectural morphology from histological and electron micrograph corrosion casting studies. Choriocapillaris imaging was performed in eight healthy volunteers with OCT angiograms successfully acquired from all subjects. These results demonstrate the feasibility of ultrahigh speed OCT for in vivo dye-free choriocapillaris and choroidal vasculature imaging, in addition to conventional structural imaging.

Ultra-flattened nearly-zero dispersion and ultrahigh nonlinear slot silicon photonic crystal fibers with ultrahigh birefringence

NASA Astrophysics Data System (ADS)

Liao, Jianfei; Xie, Yingmao; Wang, Xinghua; Li, Dongbo; Huang, Tianye

2017-07-01

A slot silicon photonic crystal fiber (PCF) is proposed to simultaneously achieve ultrahigh birefringence, large nonlinearity and ultra-flattened nearly-zero dispersion over a wide wavelength range. By taking advantage on the slot effect, ultrahigh birefringence up to 0.0736 and ultrahigh nonlinear coefficient up to 211.48 W-1 m-1 for quasi-TE mode can be obtained at the wavelength of 1.55 μm. Moreover, ultra-flattened dispersion of 0.49 ps/(nm km) for quasi-TE mode can be achieved over a 180 nm wavelength range with low dispersion slope of 1.85 × 10-3 ps/(nm2 km) at 1.55 μm. Leveraging on these advantages, the proposed slot PCF has great potential for efficient all-optical signal processing applications.

Driving ferromagnetic resonance frequency of FeCoB/PZN-PT multiferroic heterostructures to Ku-band via two-step climbing: composition gradient sputtering and magnetoelectric coupling

PubMed Central

Li, Shandong; Xue, Qian; Duh, Jenq-Gong; Du, Honglei; Xu, Jie; Wan, Yong; Li, Qiang; Lü, Yueguang

2014-01-01

RF/microwave soft magnetic films (SMFs) are key materials for miniaturization and multifunctionalization of monolithic microwave integrated circuits (MMICs) and their components, which demand that the SMFs should have higher self-bias ferromagnetic resonance frequency fFMR, and can be fabricated in an IC compatible process. However, self-biased metallic SMFs working at X-band or higher frequency were rarely reported, even though there are urgent demands. In this paper, we report an IC compatible process with two-step superposition to prepare SMFs, where the FeCoB SMFs were deposited on (011) lead zinc niobate–lead titanate substrates using a composition gradient sputtering method. As a result, a giant magnetic anisotropy field of 1498 Oe, 1–2 orders of magnitude larger than that by conventional magnetic annealing method, and an ultrahigh fFMR of up to 12.96 GHz reaching Ku-band, were obtained at zero magnetic bias field in the as-deposited films. These ultrahigh microwave performances can be attributed to the superposition of two effects: uniaxial stress induced by composition gradient and magnetoelectric coupling. This two-step superposition method paves a way for SMFs to surpass X-band by two-step or multi-step, where a variety of magnetic anisotropy field enhancing methods can be cumulated together to get higher ferromagnetic resonance frequency. PMID:25491374

Review of total cross sections and forward scattering parameters at ultra-high energies

NASA Astrophysics Data System (ADS)

Block, M. M.; White, A. R.

1991-10-01

We review the field of the elastic scattering of pp and (bar p)p at the ultra-high energies. The recent total cross section, sigma (sub tot), and rho-value results from the Fermilab Tevatron Collider experiments presented at the 4th 'Blois' Workshop on Elastic and Diffractive Scattering (Elba, Italy, in May, 1991), allow us a comprehensive overview of the field.

[The influence of ultrahigh-frequency electromagnetic radiation and low-intensity laser radiation on the body core temperature and basal metabolism in rats with systemic inflammation].

PubMed

Zhavoronok, I P; Molchanova, A Iu; Ulashik, V S

2012-01-01

The effects of ultrahigh-frequency electromagnetic radiation (UHF EMR) and low-intensity laser irradiation (LILI) on the body and skin temperature, oxygen consumption, production of carbon dioxide and heat release were investigated in the experiments on intact rats and during LPS-induced polyphasic fever. It was found that UHF EMR with the wavelength of 4,9 mm, 5,6 mm or 7,1 mm and LILI with the wavelength of 0.47 microm, 0.67 microm and 0.87 microm caused modulation of basal metabolism and thermal response to systemically administered lipopolysaccharide (LPS). These findings suggest that the most pronounced antipyretic and hypometabolic effects were observed after the treatment with UHF EMR at 7,1 mm and LILI at 470 microm.

Characterization of Hand Clenching in Human Sensorimotor Cortex Using High-, and Ultra-High Frequency Band Modulations of Electrocorticogram

PubMed Central

Jiang, Tianxiao; Liu, Su; Pellizzer, Giuseppe; Aydoseli, Aydin; Karamursel, Sacit; Sabanci, Pulat A.; Sencer, Altay; Gurses, Candan; Ince, Nuri F.

2018-01-01

Functional mapping of eloquent cortex before the resection of a tumor is a critical procedure for optimizing survival and quality of life. In order to locate the hand area of the motor cortex in two patients with low-grade gliomas (LGG), we recorded electrocorticogram (ECoG) from a 113 channel hybrid high-density grid (64 large contacts with diameter of 2.7 mm and 49 small contacts with diameter of 1 mm) while they executed hand clenching movements. We investigated the spatio-spectral characteristics of the neural oscillatory activity and observed that, in both patients, the hand movements were consistently associated with a wide spread power decrease in the low frequency band (LFB: 8–32 Hz) and a more localized power increase in the high frequency band (HFB: 60–280 Hz) within the sensorimotor region. Importantly, we observed significant power increase in the ultra-high frequency band (UFB: 300–800 Hz) during hand movements of both patients within a restricted cortical region close to the central sulcus, and the motor cortical “hand knob.” Among all frequency bands we studied, the UFB modulations were closest to the central sulcus and direct cortical stimulation (DCS) positive site. Both HFB and UFB modulations exhibited different timing characteristics at different locations. Power increase in HFB and UFB starting before movement onset was observed mostly at the anterior part of the activated cortical region. In addition, the spatial patterns in HFB and UFB indicated a probable postcentral shift of the hand motor function in one of the patients. We also compared the task related subband modulations captured by the small and large contacts in our hybrid grid. We did not find any significant difference in terms of band power changes. This study shows initial evidence that event-driven neural oscillatory activity recorded from ECoG can reach up to 800 Hz. The spatial distribution of UFB oscillations was found to be more focalized and closer to the central

Characterization of Hand Clenching in Human Sensorimotor Cortex Using High-, and Ultra-High Frequency Band Modulations of Electrocorticogram.

PubMed

Jiang, Tianxiao; Liu, Su; Pellizzer, Giuseppe; Aydoseli, Aydin; Karamursel, Sacit; Sabanci, Pulat A; Sencer, Altay; Gurses, Candan; Ince, Nuri F

2018-01-01

Functional mapping of eloquent cortex before the resection of a tumor is a critical procedure for optimizing survival and quality of life. In order to locate the hand area of the motor cortex in two patients with low-grade gliomas (LGG), we recorded electrocorticogram (ECoG) from a 113 channel hybrid high-density grid (64 large contacts with diameter of 2.7 mm and 49 small contacts with diameter of 1 mm) while they executed hand clenching movements. We investigated the spatio-spectral characteristics of the neural oscillatory activity and observed that, in both patients, the hand movements were consistently associated with a wide spread power decrease in the low frequency band (LFB: 8-32 Hz) and a more localized power increase in the high frequency band (HFB: 60-280 Hz) within the sensorimotor region. Importantly, we observed significant power increase in the ultra-high frequency band (UFB: 300-800 Hz) during hand movements of both patients within a restricted cortical region close to the central sulcus, and the motor cortical "hand knob." Among all frequency bands we studied, the UFB modulations were closest to the central sulcus and direct cortical stimulation (DCS) positive site. Both HFB and UFB modulations exhibited different timing characteristics at different locations. Power increase in HFB and UFB starting before movement onset was observed mostly at the anterior part of the activated cortical region. In addition, the spatial patterns in HFB and UFB indicated a probable postcentral shift of the hand motor function in one of the patients. We also compared the task related subband modulations captured by the small and large contacts in our hybrid grid. We did not find any significant difference in terms of band power changes. This study shows initial evidence that event-driven neural oscillatory activity recorded from ECoG can reach up to 800 Hz. The spatial distribution of UFB oscillations was found to be more focalized and closer to the central sulcus

Ultrahigh-field NMR spectroscopy of quadrupolar transition metals: 55Mn NMR of several solid manganese carbonyls.

PubMed

Ooms, Kristopher J; Feindel, Kirk W; Terskikh, Victor V; Wasylishen, Roderick E

2006-10-16

55Mn NMR spectra acquired at 21.14 T (nu(L)(55Mn) = 223.1 MHz) are presented and demonstrate the advantages of using ultrahigh magnetic fields for characterizing the chemical shift tensors of several manganese carbonyls: eta5-CpMn(CO)3, Mn2(CO)10, and (CO)5MnMPh3 (M = Ge, Sn, Pb). For the compounds investigated, the anisotropies of the manganese chemical shift tensors are less than 250 ppm except for eta5-CpMn(CO)3, which has an anisotropy of 920 ppm. At 21.14 T, one can excite the entire m(I) = 1/2 <--> m(I) = -1/2 central transition of eta5-CpMn(CO)3, which has a breadth of approximately 700 kHz. The breadth arises from second-order quadrupolar broadening due to the 55Mn quadrupolar coupling constant of 64.3 MHz, as well as the anisotropic shielding. Subtle variations in the electric field gradient tensors at the manganese are observed for crystallographically unique sites in two of the solid pentacarbonyls, resulting in measurably different C(Q) values. MQMAS experiments are able to distinguish four magnetically unique Mn sites in (CO)(5)MnPbPh3, each with slightly different values of delta(iso), C(Q), and eta(Q).

Design and performance of an ultra-high vacuum scanning tunneling microscope operating at dilution refrigerator temperatures and high magnetic fields.

PubMed

Misra, S; Zhou, B B; Drozdov, I K; Seo, J; Urban, L; Gyenis, A; Kingsley, S C J; Jones, H; Yazdani, A

2013-10-01

We describe the construction and performance of a scanning tunneling microscope capable of taking maps of the tunneling density of states with sub-atomic spatial resolution at dilution refrigerator temperatures and high (14 T) magnetic fields. The fully ultra-high vacuum system features visual access to a two-sample microscope stage at the end of a bottom-loading dilution refrigerator, which facilitates the transfer of in situ prepared tips and samples. The two-sample stage enables location of the best area of the sample under study and extends the experiment lifetime. The successful thermal anchoring of the microscope, described in detail, is confirmed through a base temperature reading of 20 mK, along with a measured electron temperature of 250 mK. Atomically resolved images, along with complementary vibration measurements, are presented to confirm the effectiveness of the vibration isolation scheme in this instrument. Finally, we demonstrate that the microscope is capable of the same level of performance as typical machines with more modest refrigeration by measuring spectroscopic maps at base temperature both at zero field and in an applied magnetic field.

Feature Screening in Ultrahigh Dimensional Cox's Model.

PubMed

Yang, Guangren; Yu, Ye; Li, Runze; Buu, Anne

Survival data with ultrahigh dimensional covariates such as genetic markers have been collected in medical studies and other fields. In this work, we propose a feature screening procedure for the Cox model with ultrahigh dimensional covariates. The proposed procedure is distinguished from the existing sure independence screening (SIS) procedures (Fan, Feng and Wu, 2010, Zhao and Li, 2012) in that the proposed procedure is based on joint likelihood of potential active predictors, and therefore is not a marginal screening procedure. The proposed procedure can effectively identify active predictors that are jointly dependent but marginally independent of the response without performing an iterative procedure. We develop a computationally effective algorithm to carry out the proposed procedure and establish the ascent property of the proposed algorithm. We further prove that the proposed procedure possesses the sure screening property. That is, with the probability tending to one, the selected variable set includes the actual active predictors. We conduct Monte Carlo simulation to evaluate the finite sample performance of the proposed procedure and further compare the proposed procedure and existing SIS procedures. The proposed methodology is also demonstrated through an empirical analysis of a real data example.

Assessment of the Nucleus-to-Cytoplasmic Ratio in MCF-7 Cells Using Ultra-high Frequency Ultrasound and Photoacoustics

NASA Astrophysics Data System (ADS)

Moore, M. J.; Strohm, E. M.; Kolios, M. C.

2016-12-01

The nucleus-to-cytoplasmic (N:C) ratio of a cell is often used when assessing histology for the presence of malignant disease. In this proof of concept study, we present a new, non-optical method for determination of the N:C ratio using ultra-high Frequency ultrasound (US) and photoacoustics (PA). When using transducers in the 100 MHz-500 MHz range, backscattered US pulses and emitted PA waves are encoded with information pertaining to the dimension and morphology of micron-sized objects. If biological cells are interrogated, the diameter of the scattering or absorbing structure can be assessed by fitting the power spectra of the measured US or PA signals to theoretical models for US backscatter and PA emission from a fluid sphere. In this study, the cell and nucleus diameters of 9 MCF-7 breast cancer cells were determined using a new simplified model that calculates the theoretical values of the location of the power spectra minima for both US and PA signals. These diameters were then used to calculate the N:C ratio of the measured cells. The average cell diameter determined by US pulses from a transducer with a central frequency of 375 MHz was found to be 15.5 μ m± 1.8 μ m. The PA waves emitted by the cell nuclei were used to determine an average nuclear diameter of 12.0 μ m± 1.3 μ m. The N:C ratio for these cells was calculated to be 1.9± 1.0, which agrees well with previously reported N:C values for this cell type.

Ultrahigh energy cosmic rays from nearby starburst galaxies

NASA Astrophysics Data System (ADS)

Attallah, Reda; Bouchachi, Dallel

2018-04-01

Ultrahigh energy cosmic rays are the most energetic of any subatomic particles ever observed in nature. The quest for their mysterious origin is currently a major scientific challenge. Here we explore the possibility that these particles originate from nearby starburst galaxies, a scenario that matches the recent observation by the Telescope Array experiment of a cosmic-ray hotspot above 57 EeV not far from the direction of the starburst galaxy M82. Specifically, we study the stochastic propagation in space of ultrahigh energy cosmic rays through the state-of-the-art simulation framework CRPropa 3, taking into account all relevant particle interactions as well as deflections by the intervening magnetic fields. To ensure a comprehensive understanding of this model, we consider the energy spectrum, the cosmogenic neutrinos and gamma rays, and the distribution of arrival directions. The starburst galaxy scenario reproduces well observations from both the Telescope Array and Pierre Auger Observatories, making it very attractive for explaining the origin of cosmic rays at the highest energies.

Ultrahigh energy cosmic rays from nearby starburst galaxies

NASA Astrophysics Data System (ADS)

Attallah, Reda; Bouchachi, Dallel

2018-07-01

Ultrahigh energy cosmic rays are the most energetic of any subatomic particles ever observed in nature. The quest for their mysterious origin is currently a major scientific challenge. Here we explore the possibility that these particles originate from nearby starburst galaxies, a scenario that matches the recent observation by the Telescope Array experiment of a cosmic ray hotspot above 57 EeV not far from the direction of the starburst galaxy M82. Specifically, we study the stochastic propagation in space of ultrahigh ENERGY cosmic rays through the state-of-the-art simulation framework CRPROPA 3, taking into account all relevant particle interactions as well as deflections by the intervening magnetic fields. To ensure a comprehensive understanding of this model, we consider the energy spectrum, the cosmogenic neutrinos and gamma rays, and the distribution of arrival directions. The starburst galaxy scenario reproduces well observations from both the Telescope Array and Pierre Auger Observatories, making it very attractive for explaining the origin of cosmic rays at the highest energies.

Effects of low-frequency magnetic fields on embryonic development and pregnancy.

PubMed

Juutilainen, J

1991-06-01

Experimental and epidemiologic studies on the effects of low-frequency magnetic fields on pregnancy are reviewed. The literature suggests that these fields have adverse effects on chick embryo development. The interaction mechanism is not known. The results of experiments with mammals are inconsistent. There is more evidence of effects on mice than on rats, and the data suggest that fetal loss might be increased rather than malformations. Most of the epidemiologic studies related to pregnancy and low-frequency magnetic fields have concerned operators of a video display terminal (VDT). The results do not provide evidence for an association between adverse pregnancy outcome and use of a VDT. Other (stronger) sources of low-frequency magnetic fields have been addressed in only a few studies. It is not yet possible to conclude whether occupational or residential exposure to low-frequency magnetic fields affects human prenatal development. There is an apparent need for further investigation.

Development of a driving method suitable for ultrahigh-speed shooting in a 2M-fps 300k-pixel single-chip color camera

NASA Astrophysics Data System (ADS)

Yonai, J.; Arai, T.; Hayashida, T.; Ohtake, H.; Namiki, J.; Yoshida, T.; Etoh, T. Goji

2012-03-01

We have developed an ultrahigh-speed CCD camera that can capture instantaneous phenomena not visible to the human eye and impossible to capture with a regular video camera. The ultrahigh-speed CCD was specially constructed so that the CCD memory between the photodiode and the vertical transfer path of each pixel can store 144 frames each. For every one-frame shot, the electric charges generated from the photodiodes are transferred in one step to the memory of all the parallel pixels, making ultrahigh-speed shooting possible. Earlier, we experimentally manufactured a 1M-fps ultrahigh-speed camera and tested it for broadcasting applications. Through those tests, we learned that there are cases that require shooting speeds (frame rate) of more than 1M fps; hence we aimed to develop a new ultrahigh-speed camera that will enable much faster shooting speeds than what is currently possible. Since shooting at speeds of more than 200,000 fps results in decreased image quality and abrupt heating of the image sensor and drive circuit board, faster speeds cannot be achieved merely by increasing the drive frequency. We therefore had to improve the image sensor wiring layout and the driving method to develop a new 2M-fps, 300k-pixel ultrahigh-speed single-chip color camera for broadcasting purposes.

Measurements and modeling of radio frequency field structures in a helicon plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, C. A.; Chen, Guangye; Arefiev, A. V.

2011-01-01

Measurements of the radio frequency (rf) field structure, plasma density, and electron temperature are presented for a 1 kW argon helicon plasma source. The measured profiles change considerably when the equilibrium magnetic field is reversed. The measured rf fields are identified as fields of radially localized helicon waves, which propagate in the axial direction. The rf field structure is compared to the results of two-dimensional cold plasma full-wave simulations for the measured density profiles. Electron collision frequency is adjusted in the simulations to match the simulated and measured field profiles. The resulting frequency is anomalously high, which is attributed tomore » the excitation of an ion-acoustic instability. The calculated power deposition is insensitive to the collision frequency and accounts for most of the power supplied by the rf-generator.« less

Simulation of ultra-high energy photon propagation in the geomagnetic field

NASA Astrophysics Data System (ADS)

Homola, P.; Góra, D.; Heck, D.; Klages, H.; PeĶala, J.; Risse, M.; Wilczyńska, B.; Wilczyński, H.

2005-12-01

The identification of primary photons or specifying stringent limits on the photon flux is of major importance for understanding the origin of ultra-high energy (UHE) cosmic rays. UHE photons can initiate particle cascades in the geomagnetic field, which leads to significant changes in the subsequent atmospheric shower development. We present a Monte Carlo program allowing detailed studies of conversion and cascading of UHE photons in the geomagnetic field. The program named PRESHOWER can be used both as an independent tool or together with a shower simulation code. With the stand-alone version of the code it is possible to investigate various properties of the particle cascade induced by UHE photons interacting in the Earth's magnetic field before entering the Earth's atmosphere. Combining this program with an extensive air shower simulation code such as CORSIKA offers the possibility of investigating signatures of photon-initiated showers. In particular, features can be studied that help to discern such showers from the ones induced by hadrons. As an illustration, calculations for the conditions of the southern part of the Pierre Auger Observatory are presented. Catalogue identifier:ADWG Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWG Program obtainable: CPC Program Library, Quen's University of Belfast, N. Ireland Computer on which the program has been thoroughly tested:Intel-Pentium based PC Operating system:Linux, DEC-Unix Programming language used:C, FORTRAN 77 Memory required to execute with typical data:<100 kB No. of bits in a word:32 Has the code been vectorized?:no Number of lines in distributed program, including test data, etc.:2567 Number of bytes in distributed program, including test data, etc.:25 690 Distribution format:tar.gz Other procedures used in PRESHOWER:IGRF [N.A. Tsyganenko, National Space Science Data Center, NASA GSFC, Greenbelt, MD 20771, USA, http://nssdc.gsfc.nasa.gov/space/model/magnetos/data-based/geopack.html], bessik

Chemically etched ultrahigh-Q wedge-resonator on a silicon chip

NASA Astrophysics Data System (ADS)

Lee, Hansuek; Chen, Tong; Li, Jiang; Yang, Ki Youl; Jeon, Seokmin; Painter, Oskar; Vahala, Kerry J.

2012-06-01

Ultrahigh-Q optical resonators are being studied across a wide range of fields, including quantum information, nonlinear optics, cavity optomechanics and telecommunications. Here, we demonstrate a new resonator with a record Q-factor of 875 million for on-chip devices. The fabrication of our device avoids the requirement for a specialized processing step, which in microtoroid resonators has made it difficult to control their size and achieve millimetre- and centimetre-scale diameters. Attaining these sizes is important in applications such as microcombs and potentially also in rotation sensing. As an application of size control, stimulated Brillouin lasers incorporating our device are demonstrated. The resonators not only set a new benchmark for the Q-factor on a chip, but also provide, for the first time, full compatibility of this important device class with conventional semiconductor processing. This feature will greatly expand the range of possible `system on a chip' functions enabled by ultrahigh-Q devices.

Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging

PubMed Central

Raval, Shailesh B.; Britton, Cynthia A.; Zhao, Tiejun; Krishnamurthy, Narayanan; Santini, Tales; Gorantla, Vijay S.; Ibrahim, Tamer S.

2017-01-01

Objective The purpose of this study was to explore the efficacy of Ultra-high field [UHF] 7 Tesla [T] MRI as compared to 3T MRI in non-contrast enhanced [nCE] imaging of structural anatomy in the elbow, forearm, and hand [upper extremity]. Materials and method A wide range of sequences including T1 weighted [T1] volumetric interpolate breath-hold exam [VIBE], T2 weighted [T2] double-echo steady state [DESS], susceptibility weighted imaging [SWI], time-of-flight [TOF], diffusion tensor imaging [DTI], and diffusion spectrum imaging [DSI] were optimized and incorporated with a radiofrequency [RF] coil system composed of a transverse electromagnetic [TEM] transmit coil combined with an 8-channel receive-only array for 7T upper extremity [UE] imaging. In addition, Siemens optimized protocol/sequences were used on a 3T scanner and the resulting images from T1 VIBE and T2 DESS were compared to that obtained at 7T qualitatively and quantitatively [SWI was only qualitatively compared]. DSI studio was utilized to identify nerves based on analysis of diffusion weighted derived fractional anisotropy images. Images of forearm vasculature were extracted using a paint grow manual segmentation method based on MIPAV [Medical Image Processing, Analysis, and Visualization]. Results High resolution and high quality signal-to-noise ratio [SNR] and contrast-to-noise ratio [CNR]—images of the hand, forearm, and elbow were acquired with nearly homogeneous 7T excitation. Measured [performed on the T1 VIBE and T2 DESS sequences] SNR and CNR values were almost doubled at 7T vs. 3T. Cartilage, synovial fluid and tendon structures could be seen with higher clarity in the 7T T1 and T2 weighted images. SWI allowed high resolution and better quality imaging of large and medium sized arteries and veins, capillary networks and arteriovenous anastomoses at 7T when compared to 3T. 7T diffusion weighted sequence [not performed at 3T] demonstrates that the forearm nerves are clearly delineated by

Atmospheric pressure reaction cell for operando sum frequency generation spectroscopy of ultrahigh vacuum grown model catalysts

NASA Astrophysics Data System (ADS)

Roiaz, Matteo; Pramhaas, Verena; Li, Xia; Rameshan, Christoph; Rupprechter, Günther

2018-04-01

A new custom-designed ultrahigh vacuum (UHV) chamber coupled to a UHV and atmospheric-pressure-compatible spectroscopic and catalytic reaction cell is described, which allows us to perform IR-vis sum frequency generation (SFG) vibrational spectroscopy during catalytic (kinetic) measurements. SFG spectroscopy is an exceptional tool to study vibrational properties of surface adsorbates under operando conditions, close to those of technical catalysis. This versatile setup allows performing surface science, SFG spectroscopy, catalysis, and electrochemical investigations on model systems, including single crystals, thin films, and deposited metal nanoparticles, under well-controlled conditions of gas composition, pressure, temperature, and potential. The UHV chamber enables us to prepare the model catalysts and to analyze their surface structure and composition by low energy electron diffraction and Auger electron spectroscopy, respectively. Thereafter, a sample transfer mechanism moves samples under UHV to the spectroscopic cell, avoiding air exposure. In the catalytic cell, SFG spectroscopy and catalytic tests (reactant/product analysis by mass spectrometry or gas chromatography) are performed simultaneously. A dedicated sample manipulation stage allows the model catalysts to be examined from LN2 temperature to 1273 K, with gaseous reactants in a pressure range from UHV to atmospheric. For post-reaction analysis, the SFG cell is rapidly evacuated and samples are transferred back to the UHV chamber. The capabilities of this new setup are demonstrated by benchmark results of CO adsorption on Pt and Pd(111) single crystal surfaces and of CO adsorption and oxidation on a ZrO2 supported Pt nanoparticle model catalyst grown by atomic layer deposition.

Wave-field decay rate estimate from the wavenumber-frequency spectra

NASA Astrophysics Data System (ADS)

Comisel, H.; Narita, Y.; Voros, Z.

2017-12-01

Observational data for wave or turbulent fields are conveniently analyzed and interpreted in the Fourier domain spanning the frequencies and the wavenumbers. If a wave field has not only oscillatory components (characterized by real parts of frequency) but also temporally decaying components (characterized by imaginary parts of frequency), the energy spectrum shows a frequency broadening around the peak due to the imaginary parts of frequency (or the decay rate). The mechanism of the frequency broadening is the same as that of the Breit-Wigner spectrum in nuclear resonance phenomena. We show that the decay rate can observationally and directly be estimated once multi-point data are available, and apply the method to Cluster four-point magnetometer data in the solar wind on a spatial scale of about 1000 km. The estimated decay rate is larger than the eddy turnover time, indicating that the decay profile of solar wind turbulence is more plasma physical such as excitation of whistler waves and other modes rather than hydrodynamic turbulence behavior.

Terapascal static pressure generation with ultrahigh yield strength nanodiamond.

PubMed

Dubrovinskaia, Natalia; Dubrovinsky, Leonid; Solopova, Natalia A; Abakumov, Artem; Turner, Stuart; Hanfland, Michael; Bykova, Elena; Bykov, Maxim; Prescher, Clemens; Prakapenka, Vitali B; Petitgirard, Sylvain; Chuvashova, Irina; Gasharova, Biliana; Mathis, Yves-Laurent; Ershov, Petr; Snigireva, Irina; Snigirev, Anatoly

2016-07-01

Studies of materials' properties at high and ultrahigh pressures lead to discoveries of unique physical and chemical phenomena and a deeper understanding of matter. In high-pressure research, an achievable static pressure limit is imposed by the strength of available strong materials and design of high-pressure devices. Using a high-pressure and high-temperature technique, we synthesized optically transparent microballs of bulk nanocrystalline diamond, which were found to have an exceptional yield strength (~460 GPa at a confining pressure of ~70 GPa) due to the unique microstructure of bulk nanocrystalline diamond. We used the nanodiamond balls in a double-stage diamond anvil cell high-pressure device that allowed us to generate static pressures beyond 1 TPa, as demonstrated by synchrotron x-ray diffraction. Outstanding mechanical properties (strain-dependent elasticity, very high hardness, and unprecedented yield strength) make the nanodiamond balls a unique device for ultrahigh static pressure generation. Structurally isotropic, homogeneous, and made of a low-Z material, they are promising in the field of x-ray optical applications.

Terapascal static pressure generation with ultrahigh yield strength nanodiamond

PubMed Central

Dubrovinskaia, Natalia; Dubrovinsky, Leonid; Solopova, Natalia A.; Abakumov, Artem; Turner, Stuart; Hanfland, Michael; Bykova, Elena; Bykov, Maxim; Prescher, Clemens; Prakapenka, Vitali B.; Petitgirard, Sylvain; Chuvashova, Irina; Gasharova, Biliana; Mathis, Yves-Laurent; Ershov, Petr; Snigireva, Irina; Snigirev, Anatoly

2016-01-01

Studies of materials’ properties at high and ultrahigh pressures lead to discoveries of unique physical and chemical phenomena and a deeper understanding of matter. In high-pressure research, an achievable static pressure limit is imposed by the strength of available strong materials and design of high-pressure devices. Using a high-pressure and high-temperature technique, we synthesized optically transparent microballs of bulk nanocrystalline diamond, which were found to have an exceptional yield strength (~460 GPa at a confining pressure of ~70 GPa) due to the unique microstructure of bulk nanocrystalline diamond. We used the nanodiamond balls in a double-stage diamond anvil cell high-pressure device that allowed us to generate static pressures beyond 1 TPa, as demonstrated by synchrotron x-ray diffraction. Outstanding mechanical properties (strain-dependent elasticity, very high hardness, and unprecedented yield strength) make the nanodiamond balls a unique device for ultrahigh static pressure generation. Structurally isotropic, homogeneous, and made of a low-Z material, they are promising in the field of x-ray optical applications. PMID:27453944

Ionic liquid gating on atomic layer deposition passivated GaN: Ultra-high electron density induced high drain current and low contact resistance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Hong; Du, Yuchen; Ye, Peide D., E-mail: yep@purdue.edu

2016-05-16

Herein, we report on achieving ultra-high electron density (exceeding 10{sup 14 }cm{sup −2}) in a GaN bulk material device by ionic liquid gating, through the application of atomic layer deposition (ALD) of Al{sub 2}O{sub 3} to passivate the GaN surface. Output characteristics demonstrate a maximum drain current of 1.47 A/mm, the highest reported among all bulk GaN field-effect transistors, with an on/off ratio of 10{sup 5} at room temperature. An ultra-high electron density exceeding 10{sup 14 }cm{sup −2} accumulated at the surface is confirmed via Hall-effect measurement and transfer length measurement. In addition to the ultra-high electron density, we also observe a reductionmore » of the contact resistance due to the narrowing of the Schottky barrier width on the contacts. Taking advantage of the ALD surface passivation and ionic liquid gating technique, this work provides a route to study the field-effect and carrier transport properties of conventional semiconductors in unprecedented ultra-high charge density regions.« less

Automatic NMR field-frequency lock-pulsed phase locked loop approach.

PubMed

Kan, S; Gonord, P; Fan, M; Sauzade, M; Courtieu, J

1978-06-01

A self-contained deuterium frequency-field lock scheme for a high-resolution NMR spectrometer is described. It is based on phase locked loop techniques in which the free induction decay signal behaves as a voltage-controlled oscillator. By pulsing the spins at an offset frequency of a few hundred hertz and using a digital phase-frequency discriminator this method not only eliminates the usual phase, rf power, offset adjustments needed in conventional lock systems but also possesses the automatic pull-in characteristics that dispense with the use of field sweeps to locate the NMR line prior to closure of the lock loop.

Active stabilization of error field penetration via control field and bifurcation of its stable frequency range

NASA Astrophysics Data System (ADS)

Inoue, S.; Shiraishi, J.; Takechi, M.; Matsunaga, G.; Isayama, A.; Hayashi, N.; Ide, S.

2017-11-01

An active stabilization effect of a rotating control field against an error field penetration is numerically studied. We have developed a resistive magnetohydrodynamic code ‘AEOLUS-IT’, which can simulate plasma responses to rotating/static external magnetic field. Adopting non-uniform flux coordinates system, the AEOLUS-IT simulation can employ high magnetic Reynolds number condition relevant to present tokamaks. By AEOLUS-IT, we successfully clarified the stabilization mechanism of the control field against the error field penetration. Physical processes of a plasma rotation drive via the control field are demonstrated by the nonlinear simulation, which reveals that the rotation amplitude at a resonant surface is not a monotonic function of the control field frequency, but has an extremum. Consequently, two ‘bifurcated’ frequency ranges of the control field are found for the stabilization of the error field penetration.

Radio frequency sheaths in an oblique magnetic field

DOE PAGES

Myra, James R.; D'Ippolito, Daniel A.

2015-06-01

The physics of radio-frequency (rf) sheaths near a conducting surface is studied for plasmas immersed in a magnetic field that makes an oblique angle θ with the surface. A set of one-dimensional equations is developed that describe the dynamics of the time-dependent magnetic presheath and non-neutral Debye sheath. The model employs Maxwell-Boltzmann electrons, and the magnetization and mobility of the ions is determined by the magnetic field strength, and wave frequency, respectively. The angle, θ assumed to be large enough to insure an electron-poor sheath, is otherwise arbitrary. Concentrating on the ion-cyclotron range of frequencies, the equations are solved numericallymore » to obtain the rectified (dc) voltage, the rf voltage across the sheath and the rf current flowing through the sheath. As an application of this model, the sheath voltage-current relation is used to obtain the rf sheath impedance, which in turn gives an rf sheath boundary condition for the electric field at the sheath-plasma interface that can be used in rf wave codes. In general the impedance has both resistive and capacitive contributions, and generalizes previous sheath boundary condition models. The resistive part contributes to parasitic power dissipation at the wall.« less

Scalable Graphene-Based Membranes for Ionic Sieving with Ultrahigh Charge Selectivity.

PubMed

Hong, Seunghyun; Constans, Charlotte; Surmani Martins, Marcos Vinicius; Seow, Yong Chin; Guevara Carrió, Juan Alfredo; Garaj, Slaven

2017-02-08

Nanostructured graphene-oxide (GO) laminate membranes, exhibiting ultrahigh water flux, are excellent candidates for next generation nanofiltration and desalination membranes, provided the ionic rejection could be further increased without compromising the water flux. Using microscopic drift-diffusion experiments, we demonstrated the ultrahigh charge selectivity for GO membranes, with more than order of magnitude difference in the permeabilities of cationic and anionic species of equivalent hydration radii. Measuring diffusion of a wide range of ions of different size and charge, we were able to clearly disentangle different physical mechanisms contributing to the ionic sieving in GO membranes: electrostatic repulsion between ions and charged chemical groups; and the compression of the ionic hydration shell within the membrane's nanochannels, following the activated behavior. The charge-selectivity allows us to rationally design membranes with increased ionic rejection and opens up the field of ion exchange and electrodialysis to the GO membranes.

Quantile Regression for Analyzing Heterogeneity in Ultra-high Dimension

PubMed Central

Wang, Lan; Wu, Yichao

2012-01-01

Ultra-high dimensional data often display heterogeneity due to either heteroscedastic variance or other forms of non-location-scale covariate effects. To accommodate heterogeneity, we advocate a more general interpretation of sparsity which assumes that only a small number of covariates influence the conditional distribution of the response variable given all candidate covariates; however, the sets of relevant covariates may differ when we consider different segments of the conditional distribution. In this framework, we investigate the methodology and theory of nonconvex penalized quantile regression in ultra-high dimension. The proposed approach has two distinctive features: (1) it enables us to explore the entire conditional distribution of the response variable given the ultra-high dimensional covariates and provides a more realistic picture of the sparsity pattern; (2) it requires substantially weaker conditions compared with alternative methods in the literature; thus, it greatly alleviates the difficulty of model checking in the ultra-high dimension. In theoretic development, it is challenging to deal with both the nonsmooth loss function and the nonconvex penalty function in ultra-high dimensional parameter space. We introduce a novel sufficient optimality condition which relies on a convex differencing representation of the penalized loss function and the subdifferential calculus. Exploring this optimality condition enables us to establish the oracle property for sparse quantile regression in the ultra-high dimension under relaxed conditions. The proposed method greatly enhances existing tools for ultra-high dimensional data analysis. Monte Carlo simulations demonstrate the usefulness of the proposed procedure. The real data example we analyzed demonstrates that the new approach reveals substantially more information compared with alternative methods. PMID:23082036

A model explaining synchronization of neuron bioelectric frequency under weak alternating low frequency magnetic field

NASA Astrophysics Data System (ADS)

del Moral, A.; Azanza, María J.

2015-03-01

A biomagnetic-electrical model is presented that explains rather well the experimentally observed synchronization of the bioelectric potential firing rate ("frequency"), f, of single unit neurons of Helix aspersa mollusc under the application of extremely low frequency (ELF) weak alternating (AC) magnetic fields (MF). The proposed model incorporates to our widely experimentally tested model of superdiamagnetism (SD) and Ca2+ Coulomb explosion (CE) from lipid (LP) bilayer membrane (SD-CE model), the electrical quadrupolar long range interaction between the bilayer LP membranes of synchronized neuron pairs, not considered before. The quadrupolar interaction is capable of explaining well the observed synchronization. Actual extension of our SD-CE-model shows that the neuron firing frequency field, B, dependence becomes not modified, but the bioelectric frequency is decreased and its spontaneous temperature, T, dependence is modified. A comparison of the model with synchronization experimental results of pair of neurons under weak (B0 ≅0.2-15 mT) AC-MF of frequency fM=50 Hz is reported. From the deduced size of synchronized LP clusters under B, is suggested the formation of small neuron networks via the membrane lipid correlation.

Ultrahigh pressure extraction of bioactive compounds from plants-A review.

PubMed

Xi, Jun

2017-04-13

Extraction of bioactive compounds from plants is one of the most important research areas for pharmaceutical and food industries. Conventional extraction techniques are usually associated with longer extraction times, lower yields, more organic solvent consumption, and poor extraction efficiency. A novel extraction technique, ultrahigh pressure extraction, has been developed for the extraction of bioactive compounds from plants, in order to shorten the extraction time, decrease the solvent consumption, increase the extraction yields, and enhance the quality of extracts. The mild processing temperature of ultrahigh pressure extraction may lead to an enhanced extraction of thermolabile bioactive ingredients. A critical review is conducted to introduce the different aspects of ultrahigh pressure extraction of plants bioactive compounds, including principles and mechanisms, the important parameters influencing its performance, comparison of ultrahigh pressure extraction with other extraction techniques, advantages, and disadvantages. The future opportunities of ultrahigh pressure extraction are also discussed.

Frequency-dependent local field factors in dielectric liquids by a polarizable force field and molecular dynamics simulations

NASA Astrophysics Data System (ADS)

Davari, Nazanin; Haghdani, Shokouh; Åstrand, Per-Olof

2015-12-01

A force field model for calculating local field factors, i.e. the linear response of the local electric field for example at a nucleus in a molecule with respect to an applied electric field, is discussed. It is based on a combined charge-transfer and point-dipole interaction model for the polarizability, and thereby it includes two physically distinct terms for describing electronic polarization: changes in atomic charges arising from transfer of charge between the atoms and atomic induced dipole moments. A time dependence is included both for the atomic charges and the atomic dipole moments and if they are assumed to oscillate with the same frequency as the applied electric field, a model for frequency-dependent properties are obtained. Furthermore, if a life-time of excited states are included, a model for the complex frequency-dependent polariability is obtained including also information about excited states and the absorption spectrum. We thus present a model for the frequency-dependent local field factors through the first molecular excitation energy. It is combined with molecular dynamics simulations of liquids where a large set of configurations are sampled and for which local field factors are calculated. We are normally not interested in the average of the local field factor but rather in configurations where it is as high as possible. In electrical insulation, we would like to avoid high local field factors to reduce the risk for electrical breakdown, whereas for example in surface-enhanced Raman spectroscopy, high local field factors are desired to give dramatically increased intensities.

Geophysical exploration with audio frequency magnetic fields

NASA Astrophysics Data System (ADS)

Labson, V. F.

1985-12-01

Experience with the Audio Frequency Magnetic (AFMAG) method has demonstrated that an electromagnetic exploration system using the Earth's natural audiofrequency magnetic fields as an energy source, is capable of mapping subsurface electrical structure in the upper kilometer of the Earth's crust. The limitations are resolved by adapting the tensor analysis and remote reference noise bias removal techniques from the geomagnetic induction and magnetotelluric methods to the computation of the tippers. After a through spectral study of the natural magnetic fields, lightweight magnetic field sensors, capable of measuring the magnetic field throughout the year were designed. A digital acquisition and processing sytem, with the ability to provide audiofrequency tipper results in the field, was then built to complete the apparatus. The new instrumetnation was used in a study of the Mariposa, California site previously mapped with AFMAG. The usefulness of natural magnetic field data in mapping an electrical conductive body was again demonstrated. Several field examples are used to demonstrate that the proposed procedure yields reasonable results.

Advanced Photon Source accelerator ultrahigh vacuum guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, C.; Noonan, J.

1994-03-01

In this document the authors summarize the following: (1) an overview of basic concepts of ultrahigh vacuum needed for the APS project, (2) a description of vacuum design and calculations for major parts of APS, including linac, linac waveguide, low energy undulator test line, positron accumulator ring (PAR), booster synchrotron ring, storage ring, and insertion devices, and (3) cleaning procedures of ultrahigh vacuum (UHV) components presently used at APS.

Large-scale three-dimensional phase-field simulations for phase coarsening at ultrahigh volume fraction on high-performance architectures

NASA Astrophysics Data System (ADS)

Yan, Hui; Wang, K. G.; Jones, Jim E.

2016-06-01

A parallel algorithm for large-scale three-dimensional phase-field simulations of phase coarsening is developed and implemented on high-performance architectures. From the large-scale simulations, a new kinetics in phase coarsening in the region of ultrahigh volume fraction is found. The parallel implementation is capable of harnessing the greater computer power available from high-performance architectures. The parallelized code enables increase in three-dimensional simulation system size up to a 5123 grid cube. Through the parallelized code, practical runtime can be achieved for three-dimensional large-scale simulations, and the statistical significance of the results from these high resolution parallel simulations are greatly improved over those obtainable from serial simulations. A detailed performance analysis on speed-up and scalability is presented, showing good scalability which improves with increasing problem size. In addition, a model for prediction of runtime is developed, which shows a good agreement with actual run time from numerical tests.

FIBER OPTICS. ACOUSTOOPTICS: High-frequency magnetooptics of fiber waveguides

NASA Astrophysics Data System (ADS)

Antonov, S. N.; Bulyuk, A. N.; Vetoshko, P. M.; Shkerdin, G. N.

1990-07-01

An investigation is made of the hf distributed magnetooptic interaction in fiber waveguides associated with the Faraday effect observed under the conditions of both spatial and temporal phase matching between the normal modes of the waveguide and an external magentic field. Analytic expressions are obtained for the main relationships governing modulation of the state of polarization of light in a long fiber waveguide at high and ultrahigh frequencies. An analysis is made of several variants of hf magnetooptic modulators. It is shown that in the specific case when a 10-m long quartz fiber waveguide wound to form a cylindrical coil is placed inside the cavity of a coaxial microwave resonator and the microwave control power is 10 W, the efficiency of modulation of light should be 50%. The main theoretical predictions were supported by the reported experiments. These experiments showed that at a frequency of 80 MHz the modulation efficiency was 1% when the control power was 0.5 W.

High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T.

PubMed

Nassirpour, Sahar; Chang, Paul; Henning, Anke

2018-03-01

Magnetic resonance spectroscopic imaging (MRSI) is a promising technique for mapping the spatial distribution of multiple metabolites in the human brain. These metabolite maps can be used as a diagnostic tool to gain insight into several biochemical processes and diseases in the brain. In comparison to lower field strengths, MRSI at ultra-high field strengths benefits from a higher signal to noise ratio (SNR) as well as higher chemical shift dispersion, and hence spectral resolution. This study combines the benefits of an ultra-high field magnet with the advantages of an ultra-short TE and TR single-slice FID-MRSI sequence (such as negligible J-evolution and loss of SNR due to T 2 relaxation effects) and presents the first metabolite maps acquired at 9.4T in the healthy human brain at both high (voxel size of 97.6µL) and ultra-high (voxel size of 24.4µL) spatial resolutions in a scan time of 11 and 46min respectively. In comparison to lower field strengths, more anatomically-detailed maps with higher SNR from a larger number of metabolites are shown. A total of 12 metabolites including glutamate (Glu), glutamine (Gln), N-acetyl-aspartyl-glutamate (NAAG), Gamma-aminobutyric acid (GABA) and glutathione (GSH) are reliably mapped. Comprehensive description of the methodology behind these maps is provided. Copyright © 2016 Elsevier Inc. All rights reserved.

Frequency Response of Graphene Electrolyte-Gated Field-Effect Transistors

PubMed Central

McVay, Elaine; Palacios, Tomás

2018-01-01

This work develops the first frequency-dependent small-signal model for graphene electrolyte-gated field-effect transistors (EGFETs). Graphene EGFETs are microfabricated to measure intrinsic voltage gain, frequency response, and to develop a frequency-dependent small-signal model. The transfer function of the graphene EGFET small-signal model is found to contain a unique pole due to a resistive element, which stems from electrolyte gating. Intrinsic voltage gain, cutoff frequency, and transition frequency for the microfabricated graphene EGFETs are approximately 3.1 V/V, 1.9 kHz, and 6.9 kHz, respectively. This work marks a critical step in the development of high-speed chemical and biological sensors using graphene EGFETs. PMID:29414868

Sensitivity and specificity considerations for fMRI encoding, decoding, and mapping of auditory cortex at ultra-high field.

PubMed

Moerel, Michelle; De Martino, Federico; Kemper, Valentin G; Schmitter, Sebastian; Vu, An T; Uğurbil, Kâmil; Formisano, Elia; Yacoub, Essa

2018-01-01

Following rapid technological advances, ultra-high field functional MRI (fMRI) enables exploring correlates of neuronal population activity at an increasing spatial resolution. However, as the fMRI blood-oxygenation-level-dependent (BOLD) contrast is a vascular signal, the spatial specificity of fMRI data is ultimately determined by the characteristics of the underlying vasculature. At 7T, fMRI measurement parameters determine the relative contribution of the macro- and microvasculature to the acquired signal. Here we investigate how these parameters affect relevant high-end fMRI analyses such as encoding, decoding, and submillimeter mapping of voxel preferences in the human auditory cortex. Specifically, we compare a T 2 * weighted fMRI dataset, obtained with 2D gradient echo (GE) EPI, to a predominantly T 2 weighted dataset obtained with 3D GRASE. We first investigated the decoding accuracy based on two encoding models that represented different hypotheses about auditory cortical processing. This encoding/decoding analysis profited from the large spatial coverage and sensitivity of the T 2 * weighted acquisitions, as evidenced by a significantly higher prediction accuracy in the GE-EPI dataset compared to the 3D GRASE dataset for both encoding models. The main disadvantage of the T 2 * weighted GE-EPI dataset for encoding/decoding analyses was that the prediction accuracy exhibited cortical depth dependent vascular biases. However, we propose that the comparison of prediction accuracy across the different encoding models may be used as a post processing technique to salvage the spatial interpretability of the GE-EPI cortical depth-dependent prediction accuracy. Second, we explored the mapping of voxel preferences. Large-scale maps of frequency preference (i.e., tonotopy) were similar across datasets, yet the GE-EPI dataset was preferable due to its larger spatial coverage and sensitivity. However, submillimeter tonotopy maps revealed biases in assigned frequency

Technique for Predicting the Radio Frequency Field Strength Inside an Enclosure

NASA Technical Reports Server (NTRS)

Hallett, Michael P.; Reddell, Jerry P.

1997-01-01

This technical memo represents a simple analytical technique for predicting the Radio Frequency (RF) field inside an enclosed volume in which radio frequency occurs. The technique was developed to predict the RF field strength within a launch vehicle fairing in which some payloads desire to launch with their telemetry transmitter radiating. This technique considers both the launch vehicle and the payload aspects.

Demonstration of the frequency offset errors introduced by an incorrect setting of the Zeeman/magnetic field adjustment on the cesium beam frequency standard

NASA Technical Reports Server (NTRS)

Kaufmann, D. C.

1976-01-01

The fine frequency setting of a cesium beam frequency standard is accomplished by adjusting the C field control with the appropriate Zeeman frequency applied to the harmonic generator. A novice operator in the field, even when using the correct Zeeman frequency input, may mistakenly set the C field to any one of seven major Beam I peaks (fingers) represented by the Ramsey curve. This can result in frequency offset errors of as much as 2.5 parts in ten to the tenth. The effects of maladjustment are demonstrated and suggestions are discussed on how to avoid the subtle traps associated with C field adjustments.

Ultrahigh-speed ultrahigh-resolution adaptive optics: optical coherence tomography system for in-vivo small animal retinal imaging

NASA Astrophysics Data System (ADS)

Jian, Yifan; Xu, Jing; Zawadzki, Robert J.; Sarunic, Marinko V.

2013-03-01

Small animal models of human retinal diseases are a critical component of vision research. In this report, we present an ultrahigh-resolution ultrahigh-speed adaptive optics optical coherence tomography (AO-OCT) system for small animal retinal imaging (mouse, fish, etc.). We adapted our imaging system to different types of small animals in accordance with the optical properties of their eyes. Results of AO-OCT images of small animal retinas acquired with AO correction are presented. Cellular structures including nerve fiber bundles, capillary networks and detailed double-cone photoreceptors are visualized.

Development of a 300,000-pixel ultrahigh-speed high-sensitivity CCD

NASA Astrophysics Data System (ADS)

Ohtake, H.; Hayashida, T.; Kitamura, K.; Arai, T.; Yonai, J.; Tanioka, K.; Maruyama, H.; Etoh, T. Goji; Poggemann, D.; Ruckelshausen, A.; van Kuijk, H.; Bosiers, Jan T.

2006-02-01

We are developing an ultrahigh-speed, high-sensitivity broadcast camera that is capable of capturing clear, smooth slow-motion videos even where lighting is limited, such as at professional baseball games played at night. In earlier work, we developed an ultrahigh-speed broadcast color camera1) using three 80,000-pixel ultrahigh-speed, highsensitivity CCDs2). This camera had about ten times the sensitivity of standard high-speed cameras, and enabled an entirely new style of presentation for sports broadcasts and science programs. Most notably, increasing the pixel count is crucially important for applying ultrahigh-speed, high-sensitivity CCDs to HDTV broadcasting. This paper provides a summary of our experimental development aimed at improving the resolution of CCD even further: a new ultrahigh-speed high-sensitivity CCD that increases the pixel count four-fold to 300,000 pixels.

High frequency circular translation pin-on-disk method for accelerated wear testing of ultrahigh molecular weight polyethylene as a bearing material in total hip arthroplasty.

PubMed

Saikko, Vesa

2015-01-21

The temporal change of the direction of sliding relative to the ultrahigh molecular weight polyethylene (UHMWPE) component of prosthetic joints is known to be of crucial importance with respect to wear. One complete revolution of the resultant friction vector is commonly called a wear cycle. It was hypothesized that in order to accelerate the wear test, the cycle frequency may be substantially increased if the circumference of the slide track is reduced in proportion, and still the wear mechanisms remain realistic and no overheating takes place. This requires an additional slow motion mechanism with which the lubrication of the contact is maintained and wear particles are conveyed away from the contact. A three-station, dual motion high frequency circular translation pin-on-disk (HF-CTPOD) device with a relative cycle frequency of 25.3 Hz and an average sliding velocity of 27.4 mm/s was designed. The pins circularly translated at high frequency (1.0 mm per cycle, 24.8 Hz, clockwise), and the disks at low frequency (31.4mm per cycle, 0.5 Hz, counter-clockwise). In a 22 million cycle (10 day) test, the wear rate of conventional gamma-sterilized UHMWPE pins against polished CoCr disks in diluted serum was 1.8 mg per 24 h, which was six times higher than that in the established 1 Hz CTPOD device. The wear mechanisms were similar. Burnishing of the pin was the predominant feature. No overheating took place. With the dual motion HF-CTPOD method, the wear testing of UHMWPE as a bearing material in total hip arthroplasty can be substantially accelerated without concerns of the validity of the wear simulation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Solution pH change in non-uniform alternating current electric fields at frequencies above the electrode charging frequency

PubMed Central

An, Ran; Massa, Katherine

2014-01-01

AC Faradaic reactions have been reported as a mechanism inducing non-ideal phenomena such as flow reversal and cell deformation in electrokinetic microfluidic systems. Prior published work described experiments in parallel electrode arrays below the electrode charging frequency (fc), the frequency for electrical double layer charging at the electrode. However, 2D spatially non-uniform AC electric fields are required for applications such as in plane AC electroosmosis, AC electrothermal pumps, and dielectrophoresis. Many microscale experimental applications utilize AC frequencies around or above fc. In this work, a pH sensitive fluorescein sodium salt dye was used to detect [H+] as an indicator of Faradaic reactions in aqueous solutions within non-uniform AC electric fields. Comparison experiments with (a) parallel (2D uniform fields) electrodes and (b) organic media were employed to deduce the electrode charging mechanism at 5 kHz (1.5fc). Time dependency analysis illustrated that Faradaic reactions exist above the theoretically predicted electrode charging frequency. Spatial analysis showed [H+] varied spatially due to electric field non-uniformities and local pH changed at length scales greater than 50 μm away from the electrode surface. Thus, non-uniform AC fields yielded spatially varied pH gradients as a direct consequence of ion path length differences while uniform fields did not yield pH gradients; the latter is consistent with prior published data. Frequency dependence was examined from 5 kHz to 12 kHz at 5.5 Vpp potential, and voltage dependency was explored from 3.5 to 7.5 Vpp at 5 kHz. Results suggest that Faradaic reactions can still proceed within electrochemical systems in the absence of well-established electrical double layers. This work also illustrates that in microfluidic systems, spatial medium variations must be considered as a function of experiment time, initial medium conditions, electric signal potential, frequency, and spatial

Measurements of intermediate-frequency electric and magnetic fields in households

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aerts, Sam, E-mail: sam.aerts@intec.ugent.be

Historically, assessment of human exposure to electric and magnetic fields has focused on the extremely-low-frequency (ELF) and radiofrequency (RF) ranges. However, research on the typically emitted fields in the intermediate-frequency (IF) range (300 Hz to 1 MHz) as well as potential effects of IF fields on the human body remains limited, although the range of household appliances with electrical components working in the IF range has grown significantly (e.g., induction cookers and compact fluorescent lighting). In this study, an extensive measurement survey was performed on the levels of electric and magnetic fields in the IF range typically present in residencesmore » as well as emitted by a wide range of household appliances under real-life circumstances. Using spot measurements, residential IF field levels were found to be generally low, while the use of certain appliances at close distance (20 cm) may result in a relatively high exposure. Overall, appliance emissions contained either harmonic signals, with fundamental frequencies between 6 kHz and 300 kHz, which were sometimes accompanied by regions in the IF spectrum of rather noisy, elevated field strengths, or much more capricious spectra, dominated by 50 Hz harmonics emanating far in the IF domain. The maximum peak field strengths recorded at 20 cm were 41.5 V/m and 2.7 A/m, both from induction cookers. Finally, none of the appliance emissions in the IF range exceeded the exposure summation rules recommended by the International Commission on Non-Ionizing Radiation Protection guidelines and the International Electrotechnical Commission (IEC 62233) standard at 20 cm and beyond (maximum exposure quotients EQ{sub E} 1.0 and {sub E}Q{sub H} 0.13). - Highlights: • Survey of residential electric and magnetic fields at intermediate frequencies (IF). • IF-EF and -MF emitted by 280 household appliances were characterised. • Strongest emitters were induction cookers, CFLs, LCD-TVs, and microwave ovens. �

Precise measurement of a magnetic field generated by the electromagnetic flux compression technique.

PubMed

Nakamura, D; Sawabe, H; Matsuda, Y H; Takeyama, S

2013-04-01

The precision of the values of a magnetic field generated by electromagnetic flux compression was investigated in ultra-high magnetic fields of up to 700 T. In an attempt to calibrate the magnetic field measured by pickup coils, precise Faraday rotation (FR) measurements were conducted on optical (quartz and crown) glasses. A discernible "turn-around" phenomenon was observed in the FR signal as well as the pickup coils before the end of a liner implosion. We found that the magnetic field measured by pickup coils should be corrected by taking into account the high-frequency response of the signal transmission line. Near the peak magnetic field, however, the pickup coils failed to provide reliable values, leaving the FR measurement as the only method to precisely measure extremely high magnetic fields.

Ultrahigh-pressure polyamorphism in GeO2 glass with coordination number >6

NASA Astrophysics Data System (ADS)

Kono, Yoshio; Kenney-Benson, Curtis; Ikuta, Daijo; Shibazaki, Yuki; Wang, Yanbin; Shen, Guoyin

2016-03-01

Knowledge of pressure-induced structural changes in glasses is important in various scientific fields as well as in engineering and industry. However, polyamorphism in glasses under high pressure remains poorly understood because of experimental challenges. Here we report new experimental findings of ultrahigh-pressure polyamorphism in GeO2 glass, investigated using a newly developed double-stage large-volume cell. The Ge-O coordination number (CN) is found to remain constant at ∼6 between 22.6 and 37.9 GPa. At higher pressures, CN begins to increase rapidly and reaches 7.4 at 91.7 GPa. This transformation begins when the oxygen-packing fraction in GeO2 glass is close to the maximal dense-packing state (the Kepler conjecture = ∼0.74), which provides new insights into structural changes in network-forming glasses and liquids with CN higher than 6 at ultrahigh-pressure conditions.

Stunning Aurora Borealis from Space - Ultra-High Definition 4K

NASA Image and Video Library

2016-04-17

NASA Television’s newest offering, NASA TV UHD, brings ultra-high definition video to a new level with the kind of imagery only the world’s leader in space exploration could provide. Harmonic produced this show exclusively for NASA TV UHD, using time-lapses shot from the International Space Station, showing both the Aurora Borealis and Aurora Australis phenomena that occur when electrically charged electrons and protons in the Earth's magnetic field collide with neutral atoms in the upper atmosphere.

47 CFR 5.87 - Frequencies for field strength surveys or equipment demonstrations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Frequencies for field strength surveys or... EXPERIMENTAL RADIO SERVICE (OTHER THAN BROADCAST) Applications and Licenses § 5.87 Frequencies for field strength surveys or equipment demonstrations. (a) Authorizations issued under §§ 5.3 (e) and (f) of this...

47 CFR 5.87 - Frequencies for field strength surveys or equipment demonstrations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Frequencies for field strength surveys or... EXPERIMENTAL RADIO SERVICE (OTHER THAN BROADCAST) Applications and Licenses § 5.87 Frequencies for field strength surveys or equipment demonstrations. (a) Authorizations issued under §§ 5.3 (e) and (f) of this...

47 CFR 5.87 - Frequencies for field strength surveys or equipment demonstrations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 1 2011-10-01 2011-10-01 false Frequencies for field strength surveys or... EXPERIMENTAL RADIO SERVICE (OTHER THAN BROADCAST) Applications and Licenses § 5.87 Frequencies for field strength surveys or equipment demonstrations. (a) Authorizations issued under §§ 5.3 (e) and (f) of this...

Coherence Volume of an Optical Wave Field with Broad Frequency and Angular Spectra

NASA Astrophysics Data System (ADS)

Lyakin, D. V.; Mysina, N. Yu.; Ryabukho, V. P.

2018-03-01

We consider the sizes of a region in a three-dimensional space in which an optical wave field excites mutually coherent perturbations. We discuss the conditions under which the length of this region along the direction of propagation of the wave field and, correspondingly, its volume are determined either by the width of the frequency spectrum of the field or by the width of its angular spectrum, or by the parameters of these spectra simultaneously. We obtain expressions for estimating extremely small values of the coherence volume of the fields with a broad frequency spectrum and an extremely broad angular spectrum. Using the notion of instantaneous speckle-modulation of the wave field, we give a physical interpretation to the occurrence of a limited coherence volume of the field. The length of the spatiotemporal coherence region in which mutually coherent perturbations occur at different times is determined. The coherence volume of a wave field that illuminates an object in high-resolution microscopy with frequency broadband light is considered. The conditions for the dominant influence of the angular or frequency spectra on the longitudinal length of the coherence region are given, and the conditions for the influence of the frequency spectrum width on the transverse coherence of the wave field are examined. We show that, when using fields with broad and ultrabroad spectra in high-resolution microscopy, this influence should be taken into account.

Analysis on optical heterodyne frequency error of full-field heterodyne interferometer

NASA Astrophysics Data System (ADS)

Li, Yang; Zhang, Wenxi; Wu, Zhou; Lv, Xiaoyu; Kong, Xinxin; Guo, Xiaoli

2017-06-01

The full-field heterodyne interferometric measurement technology is beginning better applied by employing low frequency heterodyne acousto-optical modulators instead of complex electro-mechanical scanning devices. The optical element surface could be directly acquired by synchronously detecting the received signal phases of each pixel, because standard matrix detector as CCD and CMOS cameras could be used in heterodyne interferometer. Instead of the traditional four-step phase shifting phase calculating, Fourier spectral analysis method is used for phase extracting which brings lower sensitivity to sources of uncertainty and higher measurement accuracy. In this paper, two types of full-field heterodyne interferometer are described whose advantages and disadvantages are also specified. Heterodyne interferometer has to combine two different frequency beams to produce interference, which brings a variety of optical heterodyne frequency errors. Frequency mixing error and beat frequency error are two different kinds of inescapable heterodyne frequency errors. In this paper, the effects of frequency mixing error to surface measurement are derived. The relationship between the phase extraction accuracy and the errors are calculated. :: The tolerance of the extinction ratio of polarization splitting prism and the signal-to-noise ratio of stray light is given. The error of phase extraction by Fourier analysis that caused by beat frequency shifting is derived and calculated. We also propose an improved phase extraction method based on spectrum correction. An amplitude ratio spectrum correction algorithm with using Hanning window is used to correct the heterodyne signal phase extraction. The simulation results show that this method can effectively suppress the degradation of phase extracting caused by beat frequency error and reduce the measurement uncertainty of full-field heterodyne interferometer.

Optical Measurements of Strong Radio-Frequency Fields Using Rydberg Atoms

NASA Astrophysics Data System (ADS)

Miller, Stephanie Anne

There has recently been an initiative toward establishing atomic measurement standards for field quantities, including radio-frequency, millimeter-wave, and micro-wave electric fields. Current measurement standards are obtained using dipole antennas, which are fundamentally limited in frequency bandwidth (set by the physical size of the antenna) and accuracy (due to the metal perturbing the field during the measurement). Establishing an atomic standard rectifies these problems. My thesis work contributes to an ongoing effort towards establishing the viability of using Rydberg electromagnetically induced transparency (EIT) to perform atom-based measurements of radio-frequency (RF) fields over a wide range of frequencies and field strengths, focusing on strong-field measurements. Rydberg atoms are atoms with an electron excited to a high principal quantum number, resulting in a high sensitivity to an applied field. A model based on Floquet theory is implemented to accurately describe the observed atomic energy level shifts from which information about the field is extracted. Additionally, the effects due to the different electric field domains within the measurement volume are accurately modeled. Absolute atomic measurements of fields up to 296 V/m within a +/-0.35% relative uncertainty are demonstrated. This is the strongest field measured at the time of data publication. Moreover, the uncertainty is over an order of magnitude better than that of current standards. A vacuum chamber setup that I implemented during my graduate studies is presented and its unique components are detailed. In this chamber, cold-atom samples are generated and Rydberg atoms are optically excited within the ground-state sample. The Rydberg ion detection and imaging procedure are discussed, particularly the high magnification that the system provides. By analyzing the position of the ions, the spatial correlation g(2) (r) of Rydberg-atom distributions can be extracted. Aside from ion

Anisotropy in the Arrival Directions of Ultrahigh-Energy Cosmic Rays

NASA Astrophysics Data System (ADS)

Villaseñor, Luis

2017-06-01

In this article we illustrate, in an interactive way, the analysis and visualization of anisotropy properties in the arrival directions of ultrahigh-energy cosmic rays detected by the Telescope Array and the Pierre Auger experiments by using data released by both collaborations. We describe the use of several programs that we have written in Python and Julia languages for this purpose. We also discuss the potential sources and analyse the effect of correcting the arrival directions to take into account the deflections of the cosmic rays by the magnetic field of our galaxy for one specific model of the galactic magnetic field under several assumptions about the composition of the primary cosmic rays.

Ultra-High Accelerating Gradients in Radio-Frequency Cryogenic Copper Structures

NASA Astrophysics Data System (ADS)

Cahill, Alexander David

Normal conducting radio-frequency (rf) particle accelerators have many applications, including colliders for high energy physics, high-intensity synchrotron light sources, non-destructive testing for security, and medical radiation therapy. In these applications, the accelerating gradient is an important parameter. Specifically for high energy physics, increasing the accelerating gradient extends the potential energy reach and is viewed as a way to mitigate their considerable cost. Furthermore, a gradient increase will enable for more compact and thus accessible free electron lasers (FELs). The major factor limiting larger accelerating gradients is vacuum rf breakdown. Basic physics of this phenomenon has been extensively studied over the last few decades. During which, the occurrence of rf breakdowns was shown to be probabilistic, and can be characterized by a breakdown rate. The current consensus is that vacuum rf breakdowns are caused by movements of crystal defects induced by periodic mechanical stress. The stress may be caused by pulsed surface heating and large electric fields. A compelling piece of evidence that supports this hypothesis is that accelerating structures constructed from harder materials exhibit larger accelerating gradients for similar breakdown rates. One possible method to increase sustained electric fields in copper cavities is to cool them to temperatures below 77 K, where the rf surface resistance and coefficient of thermal expansion decrease, while the yield strength (which correlates with hardness) and thermal conductivity increase. These changes in material properties at low temperature increases metal hardness and decreases the mechanical stress from exposure to rf electromagnetic fields. To test the validity of the improvement in breakdown rate, experiments were conducted with cryogenic accelerating cavities in the Accelerator Structure Test Area (ASTA) at SLAC National Accelerator Laboratory. A short 11.4 GHz standing wave

High-beta spherical tokamak startup in TS-4 merging experiment by use of toroidal field ramp-up

NASA Astrophysics Data System (ADS)

Kaminou, Yasuhiro; , Toru, II; Kato, Joji; Inomoto, Michiaki; Ono, Yasushi; TS Group Team; National InstituteFusion Science Collaboration

2014-10-01

We demonstrated the formation method of an ultrahigh-beta spherical tokamak by use of a field-reversed configuration and a spheromak in TS-4 device (R ~ 0.5 m, A ~ 1.5, Ip ~ 30-100 kA, B ~ 100 mT). This method is composed of the following steps: 1. Two spheromaks are merged together and a high-beta spheromak or FRC is formed by reconnection heating. 2. External toroidal magnetic field is added (current rising time ~50 μs), and spherical tokamak-like configuration is formed. In this way, the ultrahigh-beta ST is formed. The ultrahigh-beta ST formed by FRC has a diamagnetic toroidal field, and it presumed to be in a second-stable state for ballooning stability, and the one formed by spheromak has a weak paramagnetic toroidal magnetic field, while a spheormak has a strong paramagnetic toroidal magnetic field. This diamagnetic current derives from inductive electric field by ramping up the external toroidal magnetic field, and the diamagnetic current sustains high thermal pressure of the ultrahigh-beta spherical tokamak. And the beta of the ultrahigh-beta ST formed by FRC reaches about 50%. To sustain the high-beta state, 0.6 MW neutral beam injection and center solenoid coils are installed to the TS-4 device. In the poster, we report the experimental results of ultrahigh-beta spherical tokamak startup and sustainment by NBI and CS current driving experiment.

Ultrahigh-Resolution Optical Coherence Tomography in Glaucoma

PubMed Central

Wollstein, Gadi; Paunescu, Leila A.; Ko, Tony H.; Fujimoto, James G.; Kowalevicz, Andrew; Hartl, Ingmar; Beaton, Siobahn; Ishikawa, Hiroshi; Mattox, Cynthia; Singh, Omah; Duker, Jay; Drexler, Wolfgang; Schuman, Joel S.

2007-01-01

Objective Optical coherence tomography (OCT) has been shown to be a valuable tool in glaucoma assessment. We investigated a new ultrahigh-resolution OCT (UHR-OCT) imaging system in glaucoma patients and compared the findings with those obtained by conventional-resolution OCT. Design Retrospective comparative case series. Participants A normal subject and 4 glaucoma patients representing various stages of glaucomatous damage. Testing All participants were scanned with StratusOCT (axial resolution of ~10 μm) and UHR-OCT (axial resolution of ~3 μm) at the same visit. Main Outcome Measure Comparison of OCT findings detected with StratusOCT and UHR-OCT. Results Ultrahigh-resolution OCT provides a detailed cross-sectional view of the scanned retinal area that allows differentiation between retinal layers. These UHR images were markedly better than those obtained by the conventional-resolution OCT. Conclusions Ultrahigh-resolution OCT provides high-resolution images of the ocular posterior segment, which improves the ability to detect retinal abnormalities due to glaucoma. PMID:15691556

Frequency-tuned microwave photon counter based on a superconductive quantum interferometer

NASA Astrophysics Data System (ADS)

Shnyrkov, V. I.; Yangcao, Wu; Soroka, A. A.; Turutanov, O. G.; Lyakhno, V. Yu.

2018-03-01

Various types of single-photon counters operating in infrared, ultraviolet, and optical wavelength ranges are successfully used to study electromagnetic fields, analyze radiation sources, and solve problems in quantum informatics. However, their operating principles become ineffective at millimeter band, S-band, and ultra-high frequency bands of wavelengths due to the decrease in quantum energy by 4-5 orders of magnitude. Josephson circuits with discrete Hamiltonians and qubits are a good foundation for the construction of single-photon counters at these frequencies. This paper presents a frequency-tuned microwave photon counter based on a single-junction superconducting quantum interferometer and flux qutrit. The control pulse converts the interferometer into a two-level system for resonance absorption of photons. Decay of the photon-induced excited state changes the magnetic flux in the interferometer, which is measured by a SQUID magnetometer. Schemes for recording the magnetic flux using a DC SQUID or ideal parametric detector, based on a qutrit with high-frequency excitation, are discussed. It is shown that the counter consisting of an interferometer with a Josephson junction and a parametric detector demonstrates high performance and is capable of detecting single photons in a microwave band.

Trends in residential exposure to electromagnetic fields from 2006 to 2009.

PubMed

Tomitsch, J; Dechant, E

2012-05-01

After measuring extremely low frequency electric and magnetic fields (ELF-EFs, ELF-MFs) and radio frequency electromagnetic fields (RF-EMFs) in 2006, a follow-up investigation was done in 2009. Overall, 130 measurements in bedrooms at identical and 83 at changed locations within the same or a neighbouring building were performed. The median of ELF-EFs decreased from 25.15 to 17.35 V m(-1) from 2006 to 2009. The median of all-night ELF-MFs from power supply decreased from 16.86 to 12.76 nT, whereas the arithmetic mean was almost unchanged (+0.1%). No difference in the medians of all-night ELF-MFs of railway current was observed. RF-EMFs increased from 41.35 to 59.56 µW m(-2). Increases primarily occurred in the frequency ranges of Global System for Mobile 900 MHz, Universal Mobile Telecommunications System and Wireless Local Area Network. Television changeover from analogue to digital resulted in a reduction within the Ultra-high Frequency-band from 0.47 to 0.35 µW m(-2). The base stations of the recently established terrestrial trunked radio system caused a median of 0.05 µW m(-2).

Occupational exposure to intermediate frequency and extremely low frequency magnetic fields among personnel working near electronic article surveillance systems.

PubMed

Roivainen, Päivi; Eskelinen, Tuomo; Jokela, Kari; Juutilainen, Jukka

2014-05-01

Cashiers are potentially exposed to intermediate frequency (IF) magnetic fields at their workplaces because of the electronic article surveillance (EAS) systems used in stores to protect merchandise against theft. This study aimed at investigating occupational exposure of cashiers to IF magnetic fields in Finnish stores. Exposure to extremely low frequency (ELF) magnetic fields was also evaluated because cashiers work near various devices operating with 50 Hz electric power. The peak magnetic flux density was measured for IF magnetic fields, and was found to vary from 0.2 to 4 µT at the cashier's seat. ELF magnetic fields from 0.03 to 4.5 µT were found at the cashier's seat. These values are much lower than exposure limits. However, according to the International Commission on Non-Ionizing Radiation Protection (ICNIRP) occupational reference levels for IF magnetic fields (141 µT for the peak field) were exceeded in some cases (maximum 189 µT) for short periods of time when cashiers walked through the EAS gates. As the ICNIRP reference levels do not define any minimum time for exposure, additional investigations are recommended to determine compliance with basic restrictions. Even if the basic restrictions are not exceeded, persons working near EAS devices represent an exceptional group of workers with respect to exposure to electromagnetic fields. This group could serve as a basis for epidemiological studies addressing possible health effects of IF magnetic fields. Compliance with the reference levels for IF fields was evaluated using both broadband measurement of peak fields and the ICNIRP summation rule for multiple frequencies. The latter was generally more conservative, and the difference between the two methods was large (>10-fold) for EAS systems using a 58 kHz signal with complex waveform. This indicates that the ICNIRP multiple frequency rule can be unnecessarily conservative when measuring complex waveforms. © 2014 Wiley Periodicals, Inc.

Field stabilization studies for a radio frequency quadrupole accelerator

NASA Astrophysics Data System (ADS)

Gaur, R.; Kumar, V.

2014-07-01

The Radio Frequency Quadrupole (RFQ) linear accelerator is an accelerator that efficiently focuses, bunches and accelerates a high intensity DC beam from an ion source, for various applications. Unlike other conventional RF linear accelerators, the electromagnetic mode used for its operation is not the lowest frequency mode supported by the structure. In a four vane type RFQ, there are several undesired electromagnetic modes having frequency close to that of the operating mode. While designing an RFQ accelerator, care must be taken to ensure that the frequencies of these nearby modes are sufficiently separated from the operating mode. If the undesired nearby modes have frequencies close to the operating mode, the electromagnetic field pattern in the presence of geometrical errors will not be stabilized to the desired field profile, and will be perturbed by the nearby modes. This will affect the beam dynamics and reduce the beam transmission. In this paper, we present a detailed study of the electromagnetic modes supported, which is followed by calculations for implementation of suitable techniques to make the desired operating mode stable against mixing with unwanted modes for an RFQ being designed for the proposed Indian Spallation Neutron Source (ISNS) project at Raja Ramanna Centre for Advanced Technology, Indore. Resonant coupling scheme, along with dipole stabilization rods has been proposed to increase the mode separation. The paper discusses the details of a generalized optimization procedure that has been used for the design of mode stabilization scheme.

Bridging the gap between system and cell: The role of ultra-high field MRI in human neuroscience.

PubMed

Turner, Robert; De Haan, Daniel

2017-01-01

The volume of published research at the levels of systems and cellular neuroscience continues to increase at an accelerating rate. At the same time, progress in psychiatric medicine has stagnated and scientific confidence in cognitive psychology research is under threat due to careless analysis methods and underpowered experiments. With the advent of ultra-high field MRI, with submillimeter image voxels, imaging neuroscience holds the potential to bridge the cellular and systems levels. Use of these accurate and precisely localized quantitative measures of brain activity may go far in providing more secure foundations for psychology, and hence for more appropriate treatment and management of psychiatric illness. However, fundamental issues regarding the construction of testable mechanistic models using imaging data require careful consideration. This chapter summarizes the characteristics of acceptable models of brain function and provides concise descriptions of the relevant types of neuroimaging data that have recently become available. Approaches to data-driven experiments and analyses are described that may lead to more realistic conceptions of the competences of neural assemblages, as they vary across the brain's complex neuroanatomy. © 2017 Elsevier B.V. All rights reserved.

Two-dimensional single-shot diffusion-weighted stimulated EPI with reduced FOV for ultrahigh-b radial diffusion-weighted imaging of spinal cord.

PubMed

Sapkota, Nabraj; Shi, Xianfeng; Shah, Lubdha M; Bisson, Erica F; Rose, John W; Jeong, Eun-Kee

2017-06-01

High-resolution diffusion-weighted imaging (DWI) of the spinal cord (SC) is problematic because of the small cross-section of the SC and the large field inhomogeneity. Obtaining the ultrahigh-b DWI poses a further challenge. The purpose of the study was to design and validate two-dimensional (2D) single-shot diffusion-weighted stimulated echo planar imaging with reduced field of view (2D ss-DWSTEPI-rFOV) for ultrahigh-b radial DWI (UHB-rDWI) of the SC. A novel time-efficient 2D ss-DWSTEPI-rFOV sequence was developed based on the stimulated echo sequence. Reduced-phase field of view was obtained by using two slice-selective 90 ° radiofrequency pulses in the presence of the orthogonal slice selection gradients. The sequence was validated on a cylindrical phantom and demonstrated on SC imaging. Ultrahigh-b radial diffusion-weighted ( bmax = 7300 s/mm2) images of the SC with greatly reduced distortion were obtained. The exponential plus constant fitting of the diffusion-decay curve estimated the constant fraction (restricted water fraction) as 0.36 ± 0.05 in the SC white matter. A novel 2D ss-DWSTEPI-rFOV sequence has been designed and demonstrated for high-resolution UHB-rDWI of localized anatomic structures with significantly reduced distortion induced by nonlinear static field inhomogeneity. Magn Reson Med 77:2167-2173, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Magnetization Switching of a Co /Pt Multilayered Perpendicular Nanomagnet Assisted by a Microwave Field with Time-Varying Frequency

NASA Astrophysics Data System (ADS)

Suto, Hirofumi; Kanao, Taro; Nagasawa, Tazumi; Mizushima, Koichi; Sato, Rie

2018-05-01

Microwave-assisted magnetization switching (MAS) is attracting attention as a method for reversing nanomagnets with a high magnetic anisotropy by using a small-amplitude magnetic field. We experimentally study MAS of a perpendicularly magnetized nanomagnet by applying a microwave magnetic field with a time-varying frequency. Because the microwave field frequency can follow the nonlinear decrease of the resonance frequency, larger magnetization excitation than that in a constant-frequency microwave field is induced, which enhances the MAS effect. The switching field decreases almost linearly as the start value of the time-varying microwave field frequency increases, and it becomes smaller than the minimum switching field in a constant-frequency microwave field. To obtain this enhancement of the MAS effect, the end value of the time-varying microwave field frequency needs to be almost the same as or lower than the critical frequency for MAS in a constant-frequency microwave field. In addition, the frequency change typically needs to take 1 ns or longer to make the rate of change slow enough for the magnetization to follow the frequency change. This switching behavior is qualitatively explained by the theory based on the macrospin model.

Analysis and design of an ultrahigh temperature hydrogen-fueled MHD generator

NASA Technical Reports Server (NTRS)

Moder, Jeffrey P.; Myrabo, Leik N.; Kaminski, Deborah A.

1993-01-01

A coupled gas dynamics/radiative heat transfer analysis of partially ionized hydrogen, in local thermodynamic equilibrium, flowing through an ultrahigh temperature (10,000-20,000 K) magnetohydrodynamic (MHD) generator is performed. Gas dynamics are modeled by a set of quasi-one-dimensional, nonlinear differential equations which account for friction, convective and radiative heat transfer, and the interaction between the ionized gas and applied magnetic field. Radiative heat transfer is modeled using nongray, absorbing-emitting 2D and 3D P-1 approximations which permit an arbitrary variation of the spectral absorption coefficient with frequency. Gas dynamics and radiative heat transfer are coupled through the energy equation and through the temperature- and density-dependent absorption coefficient. The resulting nonlinear elliptic problem is solved by iterative methods. Design of such MHD generators as onboard, open-cycle, electric power supplies for a particular advanced airbreathing propulsion concept produced an efficient and compact 128-MWe generator characterized by an extraction ratio of 35.5 percent, a power density of 10,500 MWe/cu m, and a specific (extracted) energy of 324 MJe/kg of hydrogen. The maximum wall heat flux and total wall heat load were 453 MW/sq m and 62 MW, respectively.

Ultrahigh Sensitive and Flexible Magnetoelectronics with Magnetic Nanocomposites: Toward an Additional Perception of Artificial Intelligence.

PubMed

Cai, Shu-Yi; Chang, Cheng-Han; Lin, Hung-I; Huang, Yuan-Fu; Lin, Wei-Ju; Lin, Shih-Yao; Liou, Yi-Rou; Shen, Tien-Lin; Huang, Yen-Hsiang; Tsao, Po-Wei; Tzou, Chen-Yang; Liao, Yu-Ming; Chen, Yang-Fang

2018-05-23

In recent years, flexible magnetoelectronics has attracted a great attention for its intriguing functionalities and potential applications, such as healthcare, memory, soft robots, navigation, and touchless human-machine interaction systems. Here, we provide the first attempt to demonstrate a new type of magneto-piezoresistance device, which possesses an ultrahigh sensitivity with several orders of resistance change under an external magnetic field (100 mT). In our device, Fe-Ni alloy powders are embedded in the silver nanowire-coated micropyramid polydimethylsiloxane films. Our devices can not only serve as an on/off switch but also act as a sensor that can detect different magnetic fields because of its ultrahigh sensitivity, which is very useful for the application in analog signal communication. Moreover, our devices contain several key features, including large-area and easy fabrication processes, fast response time, low working voltage, low power consumption, excellent flexibility, and admirable compatibility onto a freeform surface, which are the critical criteria for the future development of touchless human-machine interaction systems. On the basis of all of these unique characteristics, we have demonstrated a nontouch piano keyboard, instantaneous magnetic field visualization, and autonomous power system, making our new devices be integrable with magnetic field and enable to be implemented into our daily life applications with unfamiliar human senses. Our approach therefore paves a useful route for the development of wearable electronics and intelligent systems.

Metamaterial-based transmit and receive system for whole-body magnetic resonance imaging at ultra-high magnetic fields.

PubMed

Herrmann, Tim; Liebig, Thorsten; Mallow, Johannes; Bruns, Christian; Stadler, Jörg; Mylius, Judith; Brosch, Michael; Svedja, Jan Taro; Chen, Zhichao; Rennings, Andreas; Scheich, Henning; Plaumann, Markus; Hauser, Marcus J B; Bernarding, Johannes; Erni, Daniel

2018-01-01

Magnetic resonance imaging (MRI) at ultra-high fields (UHF), such as 7 T, provides an enhanced signal-to-noise ratio and has led to unprecedented high-resolution anatomic images and brain activation maps. Although a variety of radio frequency (RF) coil architectures have been developed for imaging at UHF conditions, they usually are specialized for small volumes of interests (VoI). So far, whole-body coil resonators are not available for commercial UHF human whole-body MRI systems. The goal of the present study was the development and validation of a transmit and receive system for large VoIs that operates at a 7 T human whole-body MRI system. A Metamaterial Ring Antenna System (MRAS) consisting of several ring antennas was developed, since it allows for the imaging of extended VoIs. Furthermore, the MRAS not only requires lower intensities of the irradiated RF energy, but also provides a more confined and focused injection of excitation energy on selected body parts. The MRAS consisted of several antennas with 50 cm inner diameter, 10 cm width and 0.5 cm depth. The position of the rings was freely adjustable. Conformal resonant right-/left-handed metamaterial was used for each ring antenna with two quadrature feeding ports for RF power. The system was successfully implemented and demonstrated with both a silicone oil and a water-NaCl-isopropanol phantom as well as in vivo by acquiring whole-body images of a crab-eating macaque. The potential for future neuroimaging applications was demonstrated by the acquired high-resolution anatomic images of the macaque's head. Phantom and in vivo measurements of crab-eating macaques provided high-resolution images with large VoIs up to 40 cm in xy-direction and 45 cm in z-direction. The results of this work demonstrate the feasibility of the MRAS system for UHF MRI as proof of principle. The MRAS shows a substantial potential for MR imaging of larger volumes at 7 T UHF. This new technique may provide new diagnostic potential

Metamaterial-based transmit and receive system for whole-body magnetic resonance imaging at ultra-high magnetic fields

PubMed Central

Liebig, Thorsten; Mallow, Johannes; Bruns, Christian; Stadler, Jörg; Mylius, Judith; Brosch, Michael; Svedja, Jan Taro; Chen, Zhichao; Rennings, Andreas; Scheich, Henning; Plaumann, Markus; Hauser, Marcus J. B.; Bernarding, Johannes; Erni, Daniel

2018-01-01

Magnetic resonance imaging (MRI) at ultra-high fields (UHF), such as 7 T, provides an enhanced signal-to-noise ratio and has led to unprecedented high-resolution anatomic images and brain activation maps. Although a variety of radio frequency (RF) coil architectures have been developed for imaging at UHF conditions, they usually are specialized for small volumes of interests (VoI). So far, whole-body coil resonators are not available for commercial UHF human whole-body MRI systems. The goal of the present study was the development and validation of a transmit and receive system for large VoIs that operates at a 7 T human whole-body MRI system. A Metamaterial Ring Antenna System (MRAS) consisting of several ring antennas was developed, since it allows for the imaging of extended VoIs. Furthermore, the MRAS not only requires lower intensities of the irradiated RF energy, but also provides a more confined and focused injection of excitation energy on selected body parts. The MRAS consisted of several antennas with 50 cm inner diameter, 10 cm width and 0.5 cm depth. The position of the rings was freely adjustable. Conformal resonant right-/left-handed metamaterial was used for each ring antenna with two quadrature feeding ports for RF power. The system was successfully implemented and demonstrated with both a silicone oil and a water-NaCl-isopropanol phantom as well as in vivo by acquiring whole-body images of a crab-eating macaque. The potential for future neuroimaging applications was demonstrated by the acquired high-resolution anatomic images of the macaque’s head. Phantom and in vivo measurements of crab-eating macaques provided high-resolution images with large VoIs up to 40 cm in xy-direction and 45 cm in z-direction. The results of this work demonstrate the feasibility of the MRAS system for UHF MRI as proof of principle. The MRAS shows a substantial potential for MR imaging of larger volumes at 7 T UHF. This new technique may provide new diagnostic potential

Wide-field high spatial frequency domain imaging of tissue microstructure

NASA Astrophysics Data System (ADS)

Lin, Weihao; Zeng, Bixin; Cao, Zili; Zhu, Danfeng; Xu, M.

2018-02-01

Wide-field tissue imaging is usually not capable of resolving tissue microstructure. We present High Spatial Frequency Domain Imaging (HSFDI) - a noncontact imaging modality that spatially maps the tissue microscopic scattering structures over a large field of view. Based on an analytical reflectance model of sub-diffusive light from forward-peaked highly scattering media, HSFDI quantifies the spatially-resolved parameters of the light scattering phase function from the reflectance of structured light modulated at high spatial frequencies. We have demonstrated with ex vivo cancerous tissue to validate the robustness of HSFDI in significant contrast and differentiation of the microstructutral parameters between different types and disease states of tissue.

[Effect of extremely low frequency magnetic field on glutathione in rat muscles].

PubMed

Ciejka, Elzbieta; Jakubowska, Ewa; Zelechowska, Paulina; Huk-Kolega, Halina; Kowalczyk, Agata; Goraca, Anna

2014-01-01

Free radicals (FR) are atoms, molecules or their fragments. Their excess leads to the development of oxidizing stress, the cause of many neoplastic, neurodegenerative and inflammatory diseases, and aging of the organism. Industrial pollution, tobacco smoke, ionizing radiation, ultrasound and magnetic field are the major FR exogenous sources. The low frequency magnetic field is still more commonly applied in the physical therapy. The aim of the presented study was to evaluate the effect of extremely low frequency magnetic field used in the magnetotherapy on the level of total glutathione, oxidized and reduced, and the redox state of the skeletal muscle cells, depending on the duration of exposure to magnetic field. The male rats, weight of 280-300 g, were randomly devided into 3 experimental groups: controls (group I) and treatment groups exposed to extremely low frequency magnetic field (ELF-MF) (group II exposed to 40 Hz, 7 mT for 0.5 h/day for 14 days and group III exposed to 40 Hz, 7 mT for 1 h/day for 14 days). Control rats were kept in a separate room not exposed to extremely low frequency magnetic field. Immediately after the last exposure, part of muscles was taken under pentobarbital anesthesia. Total glutathione, oxidized and reduced, and the redox state in the muscle tissue of animals were determined after exposure to magnetic fields. Exposure to low magnetic field: 40 Hz, 7 mT for 30 min/day and 60 min/day for 2 weeks significantly increased the total glutathione levels in the skeletal muscle compared to the control group (p < 0.001). Exposure to magnetic fields used in the magnetic therapy plays an important role in the development of adaptive mechanisms responsible for maintaining the oxidation-reduction balance in the body and depends on exposure duration.

High Speed Intact Protein Characterization Using 4X Frequency Multiplication, Ion Trap Harmonization, and 21 Tesla FTICR-MS.

PubMed

Shaw, Jared B; Gorshkov, Mikhail V; Wu, Qinghao; Paša-Tolić, Ljiljana

2018-05-01

Mass spectrometric characterization of large biomolecules, such as intact proteins, requires the specificity afforded by ultrahigh resolution mass measurements performed at both the intact mass and product ion levels. Although the performance of time-of-flight mass analyzers is steadily increasing, the choice of mass analyzer for large biomolecules (e.g., proteins >50 kDa) is generally limited to the Fourier transform family of mass analyzers such as Orbitrap and ion cyclotron resonance (FTICR-MS), with the latter providing unmatched mass resolving power and measurement accuracy. Yet, protein analyses using FTMS are largely hindered by the low acquisition rates of spectra with ultrahigh resolving power. Frequency multiple detection schemes enable FTICR-MS to overcome this fundamental barrier and achieve resolving powers and acquisition speeds 4× greater than the limits imposed by magnetic field strength. Here we expand upon earlier work on the implementation of this technique for biomolecular characterization. We report the coupling of 21T FTICR-MS, 4X frequency multiplication, ion trapping field harmonization technology, and spectral data processing methods to achieve unprecedented acquisition rates and resolving power in mass spectrometry of large intact proteins. Isotopically resolved spectra of multiply charged ubiquitin ions were acquired using detection periods as short as 12 ms. Large proteins such as apo-transferrin (MW = 78 kDa) and monoclonal antibody (MW = 150 kDa) were isotopically resolved with detection periods of 384 and 768 ms, respectively. These results illustrate the future capability of accurate characterization of large proteins on time scales compatible with online separations.

The influence of low-frequency magnetic field on plasma antioxidant capacity and heart rate.

PubMed

Ciejka, Elzbieta B; Goraca, Anna

2009-01-01

Low-frequency magnetic field is widely applied as magnetotherapy in physiotherapeutic treatment. Recognition of positive and negative effects of the magnetic field has been the subject of numerous studies. Experimental studies concern, among others, the effect of this field on the heart rate and plasma antioxidant capacity. The aim of the study was to check whether a time-variable magnetic field of constant frequency and induction affects the heart rate and plasma antioxidant capacity. The tests were performed on Spraque-Dawley rats exposed to the magnetic field of the following parameters: frequency - 40 Hz, induction - 7 mT, time of exposure - 30 and 60 minutes. The measurements of ECG and plasma antioxidant capacity expressed in the number of reduced iron ions were performed on experimental animals: before, after a single exposure and after 14 days of exposure. A significant decrease of the heart rate was observed after 14 days of exposure. A variable magnetic field of the parameters: frequency - 40 Hz, induction - 7 mT and exposure time of 14 days caused an increase of the organism antioxidant defence, whereas a variable magnetic field of the frequency of 40 Hz, induction - 7 mT and exposure time 60 minutes for 14 days caused a significant decrease of the organism antioxidant defence. The exposure time affects heart rate, plasma antioxidant capacity and the organism defense ability against free radicals.

The Sterilization Effect of Cooperative Treatment of High Voltage Electrostatic Field and Variable Frequency Pulsed Electromagnetic Field on Heterotrophic Bacteria in Circulating Cooling Water

NASA Astrophysics Data System (ADS)

Gao, Xuetong; Liu, Zhian; Zhao, Judong

2018-01-01

Compared to other treatment of industrial circulating cooling water in the field of industrial water treatment, high-voltage electrostatic field and variable frequency pulsed electromagnetic field co-sterilization technology, an advanced technology, is widely used because of its special characteristics--low energy consumption, nonpoisonous and environmentally friendly. In order to get a better cooling water sterilization effect under the premise of not polluting the environment, some experiments about sterilization of heterotrophic bacteria in industrial circulating cooling water by cooperative treatment of high voltage electrostatic field and variable frequency pulsed electromagnetic field were carried out. The comparison experiment on the sterilization effect of high-voltage electrostatic field and variable frequency pulsed electromagnetic field co-sterilization on heterotrophic bacteria in industrial circulating cooling water was carried out by change electric field strength and pulse frequency. The results show that the bactericidal rate is selective to the frequency and output voltage, and the heterotrophic bacterium can only kill under the condition of sweep frequency range and output voltage. When the voltage of the high voltage power supply is 4000V, the pulse frequency is 1000Hz and the water temperature is 30°C, the sterilization rate is 48.7%, the sterilization rate is over 90%. Results of this study have important guiding significance for future application of magnetic field sterilization.

Effect of radio frequency waves of electromagnetic field on the tubulin.

PubMed

Taghi, Mousavi; Gholamhosein, Riazi; Saeed, Rezayi-Zarchi

2013-09-01

Microtubules (MTs) are macromolecular structures consisting of tubulin heterodimers and present in almost every eukaryotic cell. MTs fulfill all conditions for generation of electromagnetic field and are electrically polar due to the electrical polarity of a tubulin heterodimer. The calculated static electric dipole moment of about 1000 Debye makes them capable of being aligned parallel to the applied electromagnetic field direction. In the present study, the tubulin heterodimers were extracted and purified from the rat brains. MTs were obtained by polymerization in vitro. Samples of microtubules were adsorbed in the absence and in the presence of electromagnetic fields with radio frequency of 900 Hz. Our results demonstrate the effect of electromagnetic field with 900 Hz frequency to change the structure of MTs. In this paper, a related patent was used that will help to better understand the studied subject.

Spectral analysis to assess exposure to extremely low frequency magnetic fields in cars.

PubMed

Paniagua, Jesús M; Rufo, Montaña; Jiménez, Antonio; Antolín, Alicia; Barberá, Jorge

2017-04-15

A type of contamination that has been little studied in cars comes from the extremely low frequency (ELF) magnetic fields generated by the vehicle's electrical devices and the magnetized metal in the tyres. The magnetic fields in cars are frequently analysed with broadband meters sensitive to a frequency range above 30Hz. This has the disadvantage that they neither detect the magnetic field of the spinning tyres nor give any information on the spectral components, which makes it impossible to adequately assess exposure. The objective of the present study was to perform spectral analyses of ELF magnetic fields in cars, to identify their frequencies, and to assess exposure based on the ICNIRP regulatory guidelines. To do this, a meter and a spectrum analyser sensitive to magnetic fields in the 5Hz-2kHz frequency range were used. Spectra were acquired for different seats, heights, and speeds, and spatially averaged exposure coefficients were calculated. The results indicated that the main emissions were detected in the 5-100Hz range, where the wheel rotation frequencies and their harmonics are found. The intensity of the rest of the emissions were negligible in comparison. The exposure quotient increases with speed, and is approximately twice as great at foot level as at head level. The magnetic field levels are lower than the reference levels (the maximum represents 3% of the ICNIRP standard), but higher than those found in residential environments and than the cut-off threshold used by the IARC to classify ELF magnetic fields in Group 2B. Copyright © 2017 Elsevier B.V. All rights reserved.

FFT-impedance spectroscopy analysis of the growth of magnetic metal nanowires in ultra-high aspect ratio InP membranes

NASA Astrophysics Data System (ADS)

Gerngross, M.-D.; Carstensen, J.; Föll, H.; Adelung, R.

2016-01-01

This paper reports on the characterization of the electrochemical growth process of magnetic nanowires in ultra-high-aspect ratio InP membranes via in situ fast Fourier transform impedance spectroscopy in a typical frequency range from 75 Hz to 18.5 kHz. The measured impedance data from the Ni, Co, and FeCo can be very well fitted using the same electric equivalent circuit consisting of a series resistance in serial connection to an RC-element and a Maxwell element. The impedance data clearly indicate the similarities in the growth behavior of Ni, Co and FeCo nanowires in ultra-high aspect ratio InP membranes—the beneficial impact of boric acid on the metal deposition in ultra-high aspect ratio membranes and the diffusion limitation of boric acid, as well as differences such as passivation or side reactions.

W(h)ither human cardiac and body magnetic resonance at ultrahigh fields? technical advances, practical considerations, applications, and clinical opportunities.

PubMed

Niendorf, Thoralf; Paul, Katharina; Oezerdem, Celal; Graessl, Andreas; Klix, Sabrina; Huelnhagen, Till; Hezel, Fabian; Rieger, Jan; Waiczies, Helmar; Frahm, Jens; Nagel, Armin M; Oberacker, Eva; Winter, Lukas

2016-09-01

The objective of this study was to document and review advances and groundbreaking progress in cardiac and body MR at ultrahigh fields (UHF, B0 ≥ 7.0 T) with the goal to attract talent, clinical adopters, collaborations and resources to the biomedical and diagnostic imaging communities. This review surveys traits, advantages and challenges of cardiac and body MR at 7.0 T. The considerations run the gamut from technical advances to clinical opportunities. Key concepts, emerging technologies, practical considerations, frontier applications and future directions of UHF body and cardiac MR are provided. Examples of UHF cardiac and body imaging strategies are demonstrated. Their added value over the kindred counterparts at lower fields is explored along with an outline of research promises. The achievements of cardiac and body UHF-MR are powerful motivators and enablers, since extra speed, signal and imaging capabilities may be invested to overcome the fundamental constraints that continue to hamper traditional cardiac and body MR applications. If practical obstacles, concomitant physics effects and technical impediments can be overcome in equal measure, sophisticated cardiac and body UHF-MR will help to open the door to new MRI and MRS approaches for basic research and clinical science, with the lessons learned at 7.0 T being transferred into broad clinical use including diagnostics and therapy guiding at lower fields. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Measurements of crossed-field demagnetisation rate of trapped field magnets at high frequencies and below 77 K

NASA Astrophysics Data System (ADS)

Baskys, A.; Patel, A.; Glowacki, B. A.

2018-06-01

Design requirements of the next generation of electric aircraft place stringent requirements on the power density required from electric motors. A future prototype planned in the scope of the European project ‘Advanced Superconducting Motor Experimental Demonstrator’ (ASuMED) considers a permanent magnet synchronous motor, where the conventional ferromagnets are replaced with superconducting trapped field magnets, which promise higher flux densities and thus higher output power without adding weight. Previous work has indicated that stacks of tape show lower cross-field demagnetisation rates to bulk (RE)BCO whilst retaining similar performance for their size, however the crossed-field demagnetisation rate has not been studied in the temperature, the magnetic field and frequency range that are relevant for the operational prototype motor. This work investigates crossed-field demagnetisation in 2G high temperature superconducting stacks at temperatures below 77 K and a frequency range above 10 Hz. This information is crucial in developing designs and determining operational time before re-magnetisation could be required.

Critical frequency for coalescence of emulsions in an AC electric field

NASA Astrophysics Data System (ADS)

Liu, Zhou; Ali, Faizi Hammad; Shum, Ho Cheung

2017-11-01

Applying an electric field to trigger the coalescence of emulsions has been applied in various applications which include crude oil recovery, emulsion stability characterization as well as pico-injection and droplet-based chemical reaction in microfluidics. In this work, we systematically investigated the responses of surfactant-stabilized emulsions to a controlled AC electric field using a customer-built chip. At a given amplitude of the AC voltage, we found a critical frequency beyond which the emulsions remain stable. When the frequency is decreased to below the critical value, emulsions coalesce immediately. Such critical frequency is found to be dependent of amplitude of the AC voltage, viscosity of the fluids, concentration and type of the surfactant as well as the electric conductivity of the droplet phase. Using a model based on the drainage of thin film, we have explored the mechanism behind and interpret this phenomenon systematically. Our work extends the understanding of the electro-coalescence of emulsions and can be beneficial for any applications involve the coalescence of droplets in an AC electric field.

Atmospheric Electric Field Measurements at 100 Hz and High Frequency Electric Phenomena

NASA Astrophysics Data System (ADS)

Conceição, Ricardo; Gonçalves da Silva, Hugo; Matthews, James; Bennett, Alec; Chubb, John

2016-04-01

Spectral response of Atmospheric Electric Potential Gradient (PG), symmetric to the Atmospheric Electric Field, gives important information about phenomena affecting these measurements with characteristic time-scales that appear in the spectra as specific periodicities. This is the case of urban pollution that has a clear weekly dependence and reveals itself on PG measurements by a ~7 day periodicity (Silva et al., 2014). While long-term time-scales (low frequencies) have been exhaustively explored in literature, short-term time-scales (high frequencies), above 1 Hz, have comparatively received much less attention (Anisimov et al., 1999). This is mainly because of the technical difficulties related with the storage of such a huge amount of data (for 100 Hz sampling two days of data uses a ~1 Gb file) and the response degradation of the field-meters at such frequencies. Nevertheless, important Electric Phenomena occurs for frequencies above 1 Hz that are worth pursuing, e.g. the Schumann Resonances have a signature of worldwide thunderstorm activity at frequencies that go from ~8 up to ~40 Hz. To that end the present work shows preliminary results on PG measurements at 100 Hz that took place on two clear-sky days (17th and 18th June 2015) on the South of Portugal, Évora (38.50° N, 7.91° W). The field-mill used is a JCI 131F installed in the University of Évora campus (at 2 m height) with a few trees and two buildings in its surroundings (~50 m away). This device was developed by John Chubb (Chubb, 2014) and manufactured by Chilworth (UK). It was calibrated in December 2013 and recent work by the author (who is honored in this study for his overwhelming contribution to atmospheric electricity) reveals basically a flat spectral response of the device up to frequencies of 100 Hz (Chubb, 2015). This makes this device suitable for the study of High Frequency Electric Phenomena. Anisimov, S.V., et al. (1999). On the generation and evolution of aeroelectric structures

Temperature dependence of frequency response characteristics in organic field-effect transistors

NASA Astrophysics Data System (ADS)

Lu, Xubing; Minari, Takeo; Liu, Chuan; Kumatani, Akichika; Liu, J.-M.; Tsukagoshi, Kazuhito

2012-04-01

The frequency response characteristics of semiconductor devices play an essential role in the high-speed operation of electronic devices. We investigated the temperature dependence of dynamic characteristics in pentacene-based organic field-effect transistors and metal-insulator-semiconductor capacitors. As the temperature decreased, the capacitance-voltage characteristics showed large frequency dispersion and a negative shift in the flat-band voltage at high frequencies. The cutoff frequency shows Arrhenius-type temperature dependence with different activation energy values for various gate voltages. These phenomena demonstrate the effects of charge trapping on the frequency response characteristics, since decreased mobility prevents a fast charge response for alternating current signals at low temperatures.

Ultrahigh-speed non-invasive widefield angiography

NASA Astrophysics Data System (ADS)

Blatter, Cedric; Klein, Thomas; Grajciar, Branislav; Schmoll, Tilman; Wieser, Wolfgang; Andre, Raphael; Huber, Robert; Leitgeb, Rainer A.

2012-07-01

Retinal and choroidal vascular imaging is an important diagnostic benefit for ocular diseases such as age-related macular degeneration. The current gold standard for vessel visualization is fluorescence angiography. We present a potential non-invasive alternative to image blood vessels based on functional Fourier domain optical coherence tomography (OCT). For OCT to compete with the field of view and resolution of angiography while maintaining motion artifacts to a minimum, ultrahigh-speed imaging has to be introduced. We employ Fourier domain mode locking swept source technology that offers high quality imaging at an A-scan rate of up to 1.68 MHz. We present retinal angiogram over ˜48 deg acquired in a few seconds in a single recording without the need of image stitching. OCT at 1060 nm allows for high penetration in the choroid and efficient separate characterization of the retinal and choroidal vascularization.

Decoding the direction of imagined visual motion using 7 T ultra-high field fMRI

PubMed Central

Emmerling, Thomas C.; Zimmermann, Jan; Sorger, Bettina; Frost, Martin A.; Goebel, Rainer

2016-01-01

There is a long-standing debate about the neurocognitive implementation of mental imagery. One form of mental imagery is the imagery of visual motion, which is of interest due to its naturalistic and dynamic character. However, so far only the mere occurrence rather than the specific content of motion imagery was shown to be detectable. In the current study, the application of multi-voxel pattern analysis to high-resolution functional data of 12 subjects acquired with ultra-high field 7 T functional magnetic resonance imaging allowed us to show that imagery of visual motion can indeed activate the earliest levels of the visual hierarchy, but the extent thereof varies highly between subjects. Our approach enabled classification not only of complex imagery, but also of its actual contents, in that the direction of imagined motion out of four options was successfully identified in two thirds of the subjects and with accuracies of up to 91.3% in individual subjects. A searchlight analysis confirmed the local origin of decodable information in striate and extra-striate cortex. These high-accuracy findings not only shed new light on a central question in vision science on the constituents of mental imagery, but also show for the first time that the specific sub-categorical content of visual motion imagery is reliably decodable from brain imaging data on a single-subject level. PMID:26481673

Design and performance of an ultra-high vacuum spin-polarized scanning tunneling microscope operating at 30 mK and in a vector magnetic field

NASA Astrophysics Data System (ADS)

von Allwörden, Henning; Eich, Andreas; Knol, Elze J.; Hermenau, Jan; Sonntag, Andreas; Gerritsen, Jan W.; Wegner, Daniel; Khajetoorians, Alexander A.

2018-03-01

We describe the design and performance of a scanning tunneling microscope (STM) that operates at a base temperature of 30 mK in a vector magnetic field. The cryogenics is based on an ultra-high vacuum (UHV) top-loading wet dilution refrigerator that contains a vector magnet allowing for fields up to 9 T perpendicular and 4 T parallel to the sample. The STM is placed in a multi-chamber UHV system, which allows in situ preparation and exchange of samples and tips. The entire system rests on a 150-ton concrete block suspended by pneumatic isolators, which is housed in an acoustically isolated and electromagnetically shielded laboratory optimized for extremely low noise scanning probe measurements. We demonstrate the overall performance by illustrating atomic resolution and quasiparticle interference imaging and detail the vibrational noise of both the laboratory and microscope. We also determine the electron temperature via measurement of the superconducting gap of Re(0001) and illustrate magnetic field-dependent measurements of the spin excitations of individual Fe atoms on Pt(111). Finally, we demonstrate spin resolution by imaging the magnetic structure of the Fe double layer on W(110).

Design and performance of an ultra-high vacuum spin-polarized scanning tunneling microscope operating at 30 mK and in a vector magnetic field.

PubMed

von Allwörden, Henning; Eich, Andreas; Knol, Elze J; Hermenau, Jan; Sonntag, Andreas; Gerritsen, Jan W; Wegner, Daniel; Khajetoorians, Alexander A

2018-03-01

We describe the design and performance of a scanning tunneling microscope (STM) that operates at a base temperature of 30 mK in a vector magnetic field. The cryogenics is based on an ultra-high vacuum (UHV) top-loading wet dilution refrigerator that contains a vector magnet allowing for fields up to 9 T perpendicular and 4 T parallel to the sample. The STM is placed in a multi-chamber UHV system, which allows in situ preparation and exchange of samples and tips. The entire system rests on a 150-ton concrete block suspended by pneumatic isolators, which is housed in an acoustically isolated and electromagnetically shielded laboratory optimized for extremely low noise scanning probe measurements. We demonstrate the overall performance by illustrating atomic resolution and quasiparticle interference imaging and detail the vibrational noise of both the laboratory and microscope. We also determine the electron temperature via measurement of the superconducting gap of Re(0001) and illustrate magnetic field-dependent measurements of the spin excitations of individual Fe atoms on Pt(111). Finally, we demonstrate spin resolution by imaging the magnetic structure of the Fe double layer on W(110).

Concurrent recording of RF pulses and gradient fields - comprehensive field monitoring for MRI.

PubMed

Brunner, David O; Dietrich, Benjamin E; Çavuşoğlu, Mustafa; Wilm, Bertram J; Schmid, Thomas; Gross, Simon; Barmet, Christoph; Pruessmann, Klaas P

2016-09-01

Reconstruction of MRI data is based on exact knowledge of all magnetic field dynamics, since the interplay of RF and gradient pulses generates the signal, defines the contrast and forms the basis of resolution in spatial and spectral dimensions. Deviations caused by various sources, such as system imperfections, delays, eddy currents, drifts or externally induced fields, can therefore critically limit the accuracy of MRI examinations. This is true especially at ultra-high fields, because many error terms scale with the main field strength, and higher available SNR renders even smaller errors relevant. Higher baseline field also often requires higher acquisition bandwidths and faster signal encoding, increasing hardware demands and the severity of many types of hardware imperfection. To address field imperfections comprehensively, in this work we propose to expand the concept of magnetic field monitoring to also encompass the recording of RF fields. In this way, all dynamic magnetic fields relevant for spin evolution are covered, including low- to audio-frequency magnetic fields as produced by main magnets, gradients and shim systems, as well as RF pulses generated with single- and multiple-channel transmission systems. The proposed approach permits field measurements concurrently with actual MRI procedures on a strict common time base. The combined measurement is achieved with an array of miniaturized field probes that measure low- to audio-frequency fields via (19) F NMR and simultaneously pick up RF pulses in the MRI system's (1) H transmit band. Field recordings can form the basis of system calibration, retrospective correction of imaging data or closed-loop feedback correction, all of which hold potential to render MRI more robust and relax hardware requirements. The proposed approach is demonstrated for a range of imaging methods performed on a 7 T human MRI system, including accelerated multiple-channel RF pulses. Copyright © 2015 John Wiley & Sons, Ltd

Isotropy Constraints on Powerful Sources of Ultrahigh-energy Cosmic Rays at 1019 eV

NASA Astrophysics Data System (ADS)

Takami, Hajime; Murase, Kohta; Dermer, Charles D.

2016-01-01

Anisotropy in the arrival direction distribution of ultrahigh-energy cosmic rays (UHECRs) produced by powerful sources is numerically evaluated. We show that nondetection of significant anisotropy at ≈ {10}19 eV at present and in future experiments imposes general upper limits on UHECR proton luminosity of steady sources as a function of source redshifts. The upper limits constrain the existence of typical steady {10}19 eV UHECR sources in the local universe and limit their local density to ≳ {10}-3 Mpc {}-3, assuming average intergalactic magnetic fields less than {10}-9 G. This isotropy, being stronger than that measured at the highest energies, may indicate the transient generation of UHECRs. Our calculations are applied for extreme high-frequency-peaked BL Lacertae objects 1ES 0229+200, 1ES 1101-232, and 1ES 0347-121, to test the UHECR-induced cascade model, in which beamed UHECR protons generate TeV radiation in transit from sources. While the magnetic-field structure surrounding the sources affects the required absolute cosmic-ray luminosity of the blazars, the magnetic-field structure surrounding the Milky Way directly affects the observed anisotropy. If these magnetic fields are weak enough, significant UHECR anisotropy from these blazars is detectable by the Pierre Auger Observatory unless the maximum energy of UHECR protons is below 1019 eV. Furthermore, if these are the sources of UHECRs above 1019 eV, a local magnetic structure surrounding the Milky Way is needed to explain the observed isotropy at ˜ {10}19 eV, which may be incompatible with large magnetic structures around all galaxies for the UHECR-induced cascade model to work with reasonable jet powers.

High Frequency Near-Field Ground Motion Excited by Strike-Slip Step Overs

NASA Astrophysics Data System (ADS)

Hu, Feng; Wen, Jian; Chen, Xiaofei

2018-03-01

We performed dynamic rupture simulations on step overs with 1-2 km step widths and present their corresponding horizontal peak ground velocity distributions in the near field within different frequency ranges. The rupture speeds on fault segments are determinant in controlling the near-field ground motion. A Mach wave impact area at the free surface, which can be inferred from the distribution of the ratio of the maximum fault-strike particle velocity to the maximum fault-normal particle velocity, is generated in the near field with sustained supershear ruptures on fault segments, and the Mach wave impact area cannot be detected with unsustained supershear ruptures alone. Sub-Rayleigh ruptures produce stronger ground motions beyond the end of fault segments. The existence of a low-velocity layer close to the free surface generates large amounts of high-frequency seismic radiation at step over discontinuities. For near-vertical step overs, normal stress perturbations on the primary fault caused by dipping structures affect the rupture speed transition, which further determines the distribution of the near-field ground motion. The presence of an extensional linking fault enhances the near-field ground motion in the extensional regime. This work helps us understand the characteristics of high-frequency seismic radiation in the vicinities of step overs and provides useful insights for interpreting the rupture speed distributions derived from the characteristics of near-field ground motion.

Characterization of ultrahigh-molecular weight cationic polyacrylamide using frit-inlet asymmetrical flow field-flow fractionation and multi-angle light scattering.

PubMed

Woo, Sohee; Lee, Ju Yong; Choi, Woonjin; Moon, Myeong Hee

2016-01-15

In this study, frit inlet asymmetrical flow field-flow fractionation (FlFFF) with multi-angle light scattering (MALS) and differential refractive index (DRI) detection is utilized for size separation, determination of molecular weight (MW), and conformation of ultrahigh-MW (10(7)-10(9) g/mol) cationic polyacrylamides (C-PAMs), a class of water-soluble copolymers based on acrylamide and vinyl-type comonomers with quaternary ammonium cations that are widely used in wastewater treatment and in paper industries. Linear and branched C-PAM copolymers prepared in two different polymerization methods (solution and emulsion) from varying amounts of crosslinking agent and initiator were size fractionated by FlFFF with field-programming. It was found experimentally that the linear copolymers from both polymerization methods were less than 10(8) g/mol in MW with compact, nearly spherical structures, while the branched C-PAM copolymers from the emulsion polymerization showed a significant increase in average MW up to ∼ 10(9)g/mol, which was about 20-fold greater than those from the solution method, and the branched copolymers had more compact or shrunken conformations. While both linear and branched copolymers less than 10(8) g/mol MW were well resolved in an increasing order of MW (normal mode), it was noted that branched copolymers prepared through emulsion polymerization exhibited significantly larger MWs of 10(8-)10(9) g/mol and eluted in the steric/hyperlayer mode, in which the elution order is reversed in an extreme run condition (strong initial field strength followed by a fast field decay during programming). Copyright © 2015 Elsevier B.V. All rights reserved.

Surface oxidation of GaN(0001): Nitrogen plasma-assisted cleaning for ultrahigh vacuum applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gangopadhyay, Subhashis; Schmidt, Thomas, E-mail: tschmidt@ifp.uni-bremen.de; Kruse, Carsten

The cleaning of metal-organic vapor-phase epitaxial GaN(0001) template layers grown on sapphire has been investigated. Different procedures, performed under ultrahigh vacuum conditions, including degassing and exposure to active nitrogen from a radio frequency nitrogen plasma source have been compared. For this purpose, x-ray photoelectron spectroscopy, reflection high-energy electron diffraction, and scanning tunneling microscopy have been employed in order to assess chemical as well as structural and morphological surface properties. Initial degassing at 600 °C under ultrahigh vacuum conditions only partially eliminates the surface contaminants. In contrast to plasma assisted nitrogen cleaning at temperatures as low as 300 °C, active-nitrogen exposure at temperaturesmore » as high as 700 °C removes the majority of oxide species from the surface. However, extended high-temperature active-nitrogen cleaning leads to severe surface roughening. Optimum results regarding both the removal of surface oxides as well as the surface structural and morphological quality have been achieved for a combination of initial low-temperature plasma-assisted cleaning, followed by a rapid nitrogen plasma-assisted cleaning at high temperature.« less

Frequency Agile Microwave Photonic Notch Filter in a Photonic Chip

DTIC Science & Technology

2016-10-21

AFRL-AFOSR-JP-TR-2016-0087 Frequency Agile Microwave Photonic Notch Filter in a Photonic Chip Benjamin Eggleton UNIVERSITY OF SYDNEY Final Report 10...REPORT TYPE      Final 3.  DATES COVERED (From - To)      14 May 2014 to 13 May 2016 4.  TITLE AND SUBTITLE Frequency Agile Microwave Photonic Notch Filter ...primary objective is to explore a novel class microwave photonic (MWP) notch filter with a very narrow isolation bandwidth, an ultrahigh stopband

The interference of electronic implants in low frequency electromagnetic fields.

PubMed

Silny, J

2003-04-01

Electronic implants such as cardiac pacemakers or nerve stimulators can be impaired in different ways by amplitude-modulated and even continuous electric or magnetic fields of strong field intensities. For the implant bearer, possible consequences of a temporary electromagnetic interference may range from a harmless impairment of his well-being to a perilous predicament. Electromagnetic interferences in all types of implants cannot be covered here due to their various locations in the body and their different sensing systems. Therefore, this presentation focuses exemplarily on the most frequently used implant, the cardiac pacemaker. In case of an electromagnetic interference the cardiac pacemaker reacts by switching to inhibition mode or to fast asynchronous pacing. At a higher disturbance voltage on the input of the pacemaker, a regular asynchronous pacing is likely to arise. In particular, the first-named interference could be highly dangerous for the pacemaker patient. The interference threshold of cardiac pacemakers depends in a complex way on a number of different factors such as: electromagnetic immunity and adjustment of the pacemaker, the composition of the applied low-frequency fields (only electric or magnetic fields or combinations of both), their frequencies and modulations, the type of pacemaker system (bipolar, unipolar) and its location in the body, as well as the body size and orientation in the field, and last but not least, certain physiological conditions of the patient (e.g. inhalation, exhalation). In extensive laboratory studies we have investigated the interference mechanisms in more than 100 cardiac pacemakers (older types as well as current models) and the resulting worst-case conditions for pacemaker patients in low-frequency electric and magnetic fields. The verification of these results in different practical everyday-life situations, e.g. in the fields of high-voltage overhead lines or those of electronic article surveillance systems is

Harmonic generation by yeast cells in response to low-frequency electric fields

NASA Astrophysics Data System (ADS)

Nawarathna, D.; Claycomb, J. R.; Cardenas, G.; Gardner, J.; Warmflash, D.; Miller, J. H., Jr.; Widger, W. R.

2006-05-01

We report on harmonic generation by budding yeast cells (Saccharomyces cerevisiae, 108cells/ml ) in response to sinusoidal electric fields with amplitudes ranging from zero to 5V/cm in the frequency range 10-300Hz . The cell-generated harmonics are found to exhibit strong amplitude and frequency dependence. Sodium metavanadate, an inhibitor of the proton pump known as H+ -ATPase, and glucose, a substrate of H+ -ATPase, are found to increase harmonic production at low amplitudes while reducing it at large amplitudes. This P-type proton pump can be driven by an oscillatory transmembrane potential, and its nonlinear response is believed to be largely responsible for harmonic production at low frequencies in yeast cells. We find that the observed harmonics show dramatic changes with time and in their field and frequency dependence after perturbing the system by adding an inhibitor, substrate, or membrane depolarizer to the cell suspension.

Separation of major catechins from green tea by ultrahigh pressure extraction.

PubMed

Jun, Xi; Shuo, Zhao; Bingbing, Lu; Rui, Zhang; Ye, Li; Deji, Shen; Guofeng, Zhou

2010-02-15

This study presents a novel extraction technique, ultrahigh pressure extraction, to obtain major catechins from green tea leaves. The effects of various high pressure level (100, 200, 300, 400, 500, 600 MPa) on the extract are examined. HPLC chromatographic analyses determine the concentration of four major catechins and caffeine. The extraction yields of active ingredients with ultrahigh pressure extraction (400 MPa pressure) for only 15 min were given the same as those of organic solvent extraction for 2h. These excellent results for the ultrahigh pressure extraction are promising for the future separation of active ingredients from traditional Chinese herbal medicine. Copyright 2009 Elsevier B.V. All rights reserved.

Acute nonlymphocytic leukemia and residential exposure to power frequency magnetic fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Severson, R.K.

1986-01-01

A population-based case-control study of adult acute nonlymphocytic leukemia (ANLL) and residential exposure to power frequency magnetic fields was conducted in King, Pierce and Snohomish Counties in Washington state. Of 164 cases who were diagnosed from January 1, 1981 through December 31, 1984, 114 were interviewed. Controls were selected from the study area on the basis of random digit dialing and frequency matched to the cases by age and sex. Analyses were undertaken to evaluate whether exposure to high levels of power frequency magnetic fields in the residence were associated with an increased risk of ANLL. Neither the directly measuredmore » magnetic fields nor the surrogate values based on the wiring configurations were associated with ANLL. Additional analyses suggested that persons with prior allergies were at decreased risk of acute myelocytic leukemia (AML). Also, persons with prior autoimmune diseases were at increased risk of AML. The increase in AML risk in rheumatoid arthritics was of borderline statistical significance. Finally, cigarette smoking was associated with an increased risk of AML. The risk of AML increased significantly with the number of years of cigarette smoking.« less

Imaging of cartilage degeneration progression in vivo using ultrahigh-resolution OCT

NASA Astrophysics Data System (ADS)

Herz, Paul R.; Bourquin, Stephane; Hsiung, Pei-lin; Ko, Tony H.; Schneider, Karl; Fujimoto, James G.; Adams, Samuel, Jr.; Roberts, Mark; Patel, Nirlep; Brezinski, Mark

2003-10-01

Ultrahigh resolution OCT is used to visualize experimentally induced osteoarthritis in a rat knee model. Using a Cr4+:Forsterite laser, ultrahigh image resolutions of 5um are achieved. Progression of osteoarthritic remodeling and cartilage degeneration are quantified. The utility of OCT for the assessment of cartilage integrity is demonstrated.

Disposable photonic integrated circuits for evanescent wave sensors by ultra-high volume roll-to-roll method.

PubMed

Aikio, Sanna; Hiltunen, Jussi; Hiitola-Keinänen, Johanna; Hiltunen, Marianne; Kontturi, Ville; Siitonen, Samuli; Puustinen, Jarkko; Karioja, Pentti

2016-02-08

Flexible photonic integrated circuit technology is an emerging field expanding the usage possibilities of photonics, particularly in sensor applications, by enabling the realization of conformable devices and introduction of new alternative production methods. Here, we demonstrate that disposable polymeric photonic integrated circuit devices can be produced in lengths of hundreds of meters by ultra-high volume roll-to-roll methods on a flexible carrier. Attenuation properties of hundreds of individual devices were measured confirming that waveguides with good and repeatable performance were fabricated. We also demonstrate the applicability of the devices for the evanescent wave sensing of ambient refractive index. The production of integrated photonic devices using ultra-high volume fabrication, in a similar manner as paper is produced, may inherently expand methods of manufacturing low-cost disposable photonic integrated circuits for a wide range of sensor applications.

Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclear 2H, 17O and 31P MRS at ultra-high field.

PubMed

Zhu, Xiao-Hong; Lu, Ming; Chen, Wei

2018-07-01

Brain energy metabolism relies predominantly on glucose and oxygen utilization to generate biochemical energy in the form of adenosine triphosphate (ATP). ATP is essential for maintaining basal electrophysiological activities in a resting brain and supporting evoked neuronal activity under an activated state. Studying complex neuroenergetic processes in the brain requires sophisticated neuroimaging techniques enabling noninvasive and quantitative assessment of cerebral energy metabolisms and quantification of metabolic rates. Recent state-of-the-art in vivo X-nuclear MRS techniques, including 2 H, 17 O and 31 P MRS have shown promise, especially at ultra-high fields, in the quest for understanding neuroenergetics and brain function using preclinical models and in human subjects under healthy and diseased conditions. Copyright © 2018 Elsevier Inc. All rights reserved.

Analysis of a piezoelectric power harvester with adjustable frequency by precise electric field method.

PubMed

Wang, Yujue; Lian, Ziyang; Yao, Mingge; Wang, Ji; Hu, Hongping

2013-10-01

A power harvester with adjustable frequency, which consists of a hinged-hinged piezoelectric bimorph and a concentrated mass, is studied by the precise electric field method (PEFM), taking into account a distribution of the electric field over the thickness. Usually, using the equivalent electric field method (EEFM), the electric field is approximated as a constant value in the piezoelectric layer. Charge on the upper electrode (UEC) of the bimorph is often assumed as output charge. However, different output charge can be obtained by integrating on electric displacement over the electrode with different thickness coordinates. Therefore, an average charge (AC) on thickness is often assumed as the output value. This method is denoted EEFM AC. The flexural vibration of the bimorph is calculated by the three methods and their results are compared. Numerical results illustrate that EEFM UEC overestimates resonant frequency, output power, and efficiency. EEFM AC can accurately calculate the output power and efficiency, but underestimates resonant frequency. The performance of the harvester, which depends on concentrated mass weight, position, and circuit load, is analyzed using PEFM. The resonant frequency can be modulated 924 Hz by moving the concentrated mass along the bimorph. This feature suggests that the natural frequency of the harvester can be adjusted conveniently to adapt to frequency fluctuation of the ambient vibration.

Routes to spatiotemporal chaos in Kerr optical frequency combs.

PubMed

Coillet, Aurélien; Chembo, Yanne K

2014-03-01

We investigate the various routes to spatiotemporal chaos in Kerr optical frequency combs, obtained through pumping an ultra-high Q-factor whispering-gallery mode resonator with a continuous-wave laser. The Lugiato-Lefever model is used to build bifurcation diagrams with regards to the parameters that are externally controllable, namely, the frequency and the power of the pumping laser. We show that the spatiotemporal chaos emerging from Turing patterns and solitons display distinctive dynamical features. Experimental spectra of chaotic Kerr combs are also presented for both cases, in excellent agreement with theoretical spectra.

Effects of radio frequency magnetic fields on iron release from cage proteins.

PubMed

Céspedes, Oscar; Ueno, Shoogo

2009-07-01

Ferritin, the iron cage protein, contains a superparamagnetic ferrihydrite nanoparticle formed from the oxidation and absorption of Fe(2+) ions. This nanoparticle increases its internal energy when exposed to alternating magnetic fields due to magnetization lag. The energy is then dissipated to the surrounding proteic cage, affecting its functioning. In this article we show that the rates of iron chelation with ferrozine, an optical marker, are reduced by up to a factor of 3 in proteins previously exposed to radio frequency magnetic fields of 1 MHz and 30 microT for several hours. The effect is non-thermal and depends on the frequency-amplitude product of the magnetic field. (c) 2009 Wiley-Liss, Inc.

SMALLER FOOTPRINT DRILLING SYSTEM FOR DEEP AND HARD ROCK ENVIRONMENTS; FEASIBILITY OF ULTRA-HIGH SPEED DIAMOND DRILLING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alan Black; Arnis Judzis

2004-10-01

The two phase program addresses long-term developments in deep well and hard rock drilling. TerraTek believes that significant improvements in drilling deep hard rock will be obtained by applying ultra-high (greater than 10,000 rpm) rotational speeds. The work includes a feasibility of concept research effort aimed at development and test results that will ultimately result in the ability to reliably drill ''faster and deeper'' possibly with rigs having a smaller footprint to be more mobile. The principle focus is on demonstration testing of diamond bits rotating at speeds in excess of 10,000 rpm to achieve high rate of penetration rockmore » cutting with substantially lower inputs of energy and loads. The project draws on TerraTek results submitted to NASA's ''Drilling on Mars'' program. The objective of that program was to demonstrate miniaturization of a robust and mobile drilling system that expends small amounts of energy. TerraTek successfully tested ultrahigh speed ({approx}40,000 rpm) small kerf diamond coring. Adaptation to the oilfield will require innovative bit designs for full hole drilling or continuous coring and the eventual development of downhole ultra-high speed drives. For domestic operations involving hard rock and deep oil and gas plays, improvements in penetration rates is an opportunity to reduce well costs and make viable certain field developments. An estimate of North American hard rock drilling costs is in excess of $1,200 MM. Thus potential savings of $200 MM to $600 MM are possible if drilling rates are doubled [assuming bit life is reasonable]. The net result for operators is improved profit margin as well as an improved position on reserves. The significance of the ''ultra-high rotary speed drilling system'' is the ability to drill into rock at very low weights on bit and possibly lower energy levels. The drilling and coring industry today does not practice this technology. The highest rotary speed systems in oil field and mining

SMALLER FOOTPRINT DRILLING SYSTEM FOR DEEP AND HARD ROCK ENVIRONMENTS; FEASIBILITY OF ULTRA-HIGH SPEED DIAMOND DRILLING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alan Black; Arnis Judzis

2004-10-01

The two phase program addresses long-term developments in deep well and hard rock drilling. TerraTek believes that significant improvements in drilling deep hard rock will be obtained by applying ultra-high (greater than 10,000 rpm) rotational speeds. The work includes a feasibility of concept research effort aimed at development and test results that will ultimately result in the ability to reliably drill ''faster and deeper'' possibly with rigs having a smaller footprint to be more mobile. The principle focus is on demonstration testing of diamond bits rotating at speeds in excess of 10,000 rpm to achieve high rate of penetration rockmore » cutting with substantially lower inputs of energy and loads. The project draws on TerraTek results submitted to NASA's ''Drilling on Mars'' program. The objective of that program was to demonstrate miniaturization of a robust and mobile drilling system that expends small amounts of energy. TerraTek successfully tested ultrahigh speed ({approx}40,000 rpm) small kerf diamond coring. Adaptation to the oilfield will require innovative bit designs for full hole drilling or continuous coring and the eventual development of downhole ultra-high speed drives. For domestic operations involving hard rock and deep oil and gas plays, improvements in penetration rates is an opportunity to reduce well costs and make viable certain field developments. An estimate of North American hard rock drilling costs is in excess of $1,200 MM. Thus potential savings of $200 MM to $600 MM are possible if drilling rates are doubled [assuming bit life is reasonable]. The net result for operators is improved profit margin as well as an improved position on reserves. The significance of the ''ultra-high rotary speed drilling system'' is the ability to drill into rock at very low weights on bit and possibly lower energy levels. The drilling and coring industry today does not practice this technology. The highest rotary speed systems in oil field and mining

Optical field enhancement of nanometer-sized gaps at near-infrared frequencies.

PubMed

Ahn, Jae Sung; Kang, Taehee; Singh, Dilip K; Bahk, Young-Mi; Lee, Hyunhwa; Choi, Soo Bong; Kim, Dai-Sik

2015-02-23

We report near-field and far-field measurements of transmission through nanometer-sized gaps at near-infrared frequencies with varying the gap size from 1 nm to 10 nm. In the far-field measurements, we excluded direct transmission on the metal film surface via interferometric method. Kirchhoff integral formalism was used to relate the far-field intensity to the electric field at the nanogaps. In near-field measurements, field enhancement factors of the nanogaps were quantified by measuring transmission of the nanogaps using near-field scanning optical microscopy. All the measurements produce similar field enhancements of about ten, which we put in the context of comparing with the giant field enhancements in the terahertz regime.

Assessment of the metrological performance of an in situ storage image sensor ultra-high speed camera for full-field deformation measurements

NASA Astrophysics Data System (ADS)

Rossi, Marco; Pierron, Fabrice; Forquin, Pascal

2014-02-01

Ultra-high speed (UHS) cameras allow us to acquire images typically up to about 1 million frames s-1 for a full spatial resolution of the order of 1 Mpixel. Different technologies are available nowadays to achieve these performances, an interesting one is the so-called in situ storage image sensor architecture where the image storage is incorporated into the sensor chip. Such an architecture is all solid state and does not contain movable devices as occurs, for instance, in the rotating mirror UHS cameras. One of the disadvantages of this system is the low fill factor (around 76% in the vertical direction and 14% in the horizontal direction) since most of the space in the sensor is occupied by memory. This peculiarity introduces a series of systematic errors when the camera is used to perform full-field strain measurements. The aim of this paper is to develop an experimental procedure to thoroughly characterize the performance of such kinds of cameras in full-field deformation measurement and identify the best operative conditions which minimize the measurement errors. A series of tests was performed on a Shimadzu HPV-1 UHS camera first using uniform scenes and then grids under rigid movements. The grid method was used as full-field measurement optical technique here. From these tests, it has been possible to appropriately identify the camera behaviour and utilize this information to improve actual measurements.

Research on Wide-field Imaging Technologies for Low-frequency Radio Array

NASA Astrophysics Data System (ADS)

Lao, B. Q.; An, T.; Chen, X.; Wu, X. C.; Lu, Y.

2017-09-01

Wide-field imaging of low-frequency radio telescopes are subject to a number of difficult problems. One particularly pernicious problem is the non-coplanar baseline effect. It will lead to distortion of the final image when the phase of w direction called w-term is ignored. The image degradation effects are amplified for telescopes with the wide field of view. This paper summarizes and analyzes several w-term correction methods and their technical principles. Their advantages and disadvantages have been analyzed after comparing their computational cost and computational complexity. We conduct simulations with two of these methods, faceting and w-projection, based on the configuration of the first-phase Square Kilometre Array (SKA) low frequency array. The resulted images are also compared with the two-dimensional Fourier transform method. The results show that image quality and correctness derived from both faceting and w-projection are better than the two-dimensional Fourier transform method in wide-field imaging. The image quality and run time affected by the number of facets and w steps have been evaluated. The results indicate that the number of facets and w steps must be reasonable. Finally, we analyze the effect of data size on the run time of faceting and w-projection. The results show that faceting and w-projection need to be optimized before the massive amounts of data processing. The research of the present paper initiates the analysis of wide-field imaging techniques and their application in the existing and future low-frequency array, and fosters the application and promotion to much broader fields.

Extremely low-frequency electromagnetic fields cause DNA strand breaks in normal cells

PubMed Central

2014-01-01

Background Extremely low frequency electromagnetic fields aren’t considered as a real carcinogenic agent despite the fact that some studies have showed impairment of the DNA integrity in different cells lines. The aim of this study was evaluation of the late effects of a 100 Hz and 5.6 mT electromagnetic field, applied continuously or discontinuously, on the DNA integrity of Vero cells assessed by alkaline Comet assay and by cell cycle analysis. Normal Vero cells were exposed to extremely low frequency electromagnetic fields (100 Hz, 5.6 mT) for 45 minutes. The Comet assay and cell cycle analysis were performed 48 hours after the treatment. Results Exposed samples presented an increase of the number of cells with high damaged DNA as compared with non-exposed cells. Quantitative evaluation of the comet assay showed a significantly (<0.001) increase of the tail lengths, of the quantity of DNA in tail and of Olive tail moments, respectively. Cell cycle analysis showed an increase of the frequency of the cells in S phase, proving the occurrence of single strand breaks. The most probable mechanism of induction of the registered effects is the production of different types of reactive oxygen species. Conclusions The analysis of the registered comet indices and of cell cycle showed that extremely low frequency electromagnetic field of 100 Hz and 5.6 mT had a genotoxic impact on Vero cells. PMID:24401758

[Extreme (complicated, ultra-high) refractive errors: terminological misconceptions!?

PubMed

Avetisov, S E

2018-01-01

The article reviews development mechanisms of different refractive errors accompanied by marked defocus of light rays reaching the retina. Terminology used for such ametropias includes terms extreme, ultra-high and complicated. Justification of their usage for primary ametropias, whose symptom complex is based on changes in axial eye length, is an ongoing discussion. To comply with thesaurus definitions of 'diagnosis' and 'pathogenesis', to characterize refractive and anatomical-functional disorders in patients with primary ametropias it is proposed to use the terms 'hyperaxial and hypoaxial syndromes' with elaboration of specific symptoms instead of such expressions as extreme (ultra-high) myopia and hypermetropia.

Ultra-High Surface Speed for Metal Removal, Artillery Shell

DTIC Science & Technology

1981-07-01

TECHNICAL LIBRARY "y/a^^cr^ AD-E400 660 CONTRACTOR REPORT ARLCD-CR- 81019 ULTRA-HIGH SURFACE SPEED FOR METAL REMOVAL, ARTILLERY SHELL RICHARD F...Report ARLCD-CR- 81019 2. GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER 4. TITLE (and Subtitle) ULTRA-HIGH SURFACE SPEED FOR METAL...UNIT* tuiPPtO 1 MIL -STD-43CA i, ASTM A-274-64 EF A1SI~1340 SEHI FIN FORGING STEEL 6 RC SQ ■ IP 120093* a LIFTS 38 PCS

An ultra-high vacuum scanning tunneling microscope operating at sub-Kelvin temperatures and high magnetic fields for spin-resolved measurements

NASA Astrophysics Data System (ADS)

Salazar, C.; Baumann, D.; Hänke, T.; Scheffler, M.; Kühne, T.; Kaiser, M.; Voigtländer, R.; Lindackers, D.; Büchner, B.; Hess, C.

2018-06-01

We present the construction and performance of an ultra-low-temperature scanning tunneling microscope (STM), working in ultra-high vacuum (UHV) conditions and in high magnetic fields up to 9 T. The cryogenic environment of the STM is generated by a single-shot 3He magnet cryostat in combination with a 4He dewar system. At a base temperature (300 mK), the cryostat has an operation time of approximately 80 h. The special design of the microscope allows the transfer of the STM head from the cryostat to a UHV chamber system, where samples and STM tips can be easily exchanged. The UHV chambers are equipped with specific surface science treatment tools for the functionalization of samples and tips, including high-temperature treatments and thin film deposition. This, in particular, enables spin-resolved tunneling measurements. We present test measurements using well-known samples and tips based on superconductors and metallic materials such as LiFeAs, Nb, Fe, and W. The measurements demonstrate the outstanding performance of the STM with high spatial and energy resolution as well as the spin-resolved capability.

Enhancing thermal reliability of fiber-optic sensors for bio-inspired applications at ultra-high temperatures

NASA Astrophysics Data System (ADS)

Kang, Donghoon; Kim, Heon-Young; Kim, Dae-Hyun

2014-07-01

The rapid growth of bio-(inspired) sensors has led to an improvement in modern healthcare and human-robot systems in recent years. Higher levels of reliability and better flexibility, essential features of these sensors, are very much required in many application fields (e.g. applications at ultra-high temperatures). Fiber-optic sensors, and fiber Bragg grating (FBG) sensors in particular, are being widely studied as suitable sensors for improved structural health monitoring (SHM) due to their many merits. To enhance the thermal reliability of FBG sensors, thermal sensitivity, generally expressed as αf + ξf and considered a constant, should be investigated more precisely. For this purpose, the governing equation of FBG sensors is modified using differential derivatives between the wavelength shift and the temperature change in this study. Through a thermal test ranging from RT to 900 °C, the thermal sensitivity of FBG sensors is successfully examined and this guarantees thermal reliability of FBG sensors at ultra-high temperatures. In detail, αf + ξf has a non-linear dependence on temperature and varies from 6.0 × 10-6 °C-1 (20 °C) to 10.6 × 10-6 °C-1 (650 °C). Also, FBGs should be carefully used for applications at ultra-high temperatures due to signal disappearance near 900 °C.

An electrostatic glass actuator for ultrahigh vacuum: A rotating light trap for continuous beams of laser-cooled atoms.

PubMed

Füzesi, F; Jornod, A; Thomann, P; Plimmer, M D; Dudle, G; Moser, R; Sache, L; Bleuler, H

2007-10-01

This article describes the design, characterization, and performance of an electrostatic glass actuator adapted to an ultrahigh vacuum environment (10(-8) mbar). The three-phase rotary motor is used to drive a turbine that acts as a velocity-selective light trap for a slow continuous beam of laser-cooled atoms. This simple, compact, and nonmagnetic device should find applications in the realm of time and frequency metrology, as well as in other areas of atomic, molecular physics and elsewhere.

Two-Wavelength Multi-Gigahertz Frequency Comb-Based Interferometry for Full-Field Profilometry

NASA Astrophysics Data System (ADS)

Choi, Samuel; Kashiwagi, Ken; Kojima, Shuto; Kasuya, Yosuke; Kurokawa, Takashi

2013-10-01

The multi-gigahertz frequency comb-based interferometer exhibits only the interference amplitude peak without the phase fringes, which can produce a rapid axial scan for full-field profilometry and tomography. Despite huge technical advantages, there remain problems that the interference intensity undulations occurred depending on the interference phase. To avoid such problems, we propose a compensation technique of the interference signals using two frequency combs with slightly varied center wavelengths. The compensated full-field surface profile measurements of cover glass and onion skin were demonstrated experimentally to verify the advantages of the proposed method.

Digital output compensation for precise frequency transfer over commercial fiber link

NASA Astrophysics Data System (ADS)

Ci, Cheng; Wu, Hong; Tang, Ran; Liu, Bo; Chen, Xing; Zhang, Xue-song; Zhang, Yu; Zhao, Ying-xin

2018-03-01

An ultra-highly precise and long-term stable frequency transmission system over 120 km commercial fiber link has been proposed and experimentally demonstrated. This system is based on digital output compensation technique to suppress phase fluctuations during the frequency transmission process. A mode-locked erbium-doped fiber laser driven by a hydrogen maser serves as an optical transmitter. Moreover, a dense wavelength division multiplexing system is able to separate forward and backward signals with reflection effect excluded. The ultimate fractional frequency instabilities for the long-distance frequency distributed system are up to 3.14×10-15 at 1 s and 2.96×10-19 at 10 000 s, respectively.

[Application study of qualitatively diagnosing prostate cancer using ultrahigh b-value DWI].

PubMed

Ji, L B; Lu, Z H; Yao, H H; Cao, Y; Lu, W W; Qian, W X; Wang, X M; Hu, C H

2017-07-18

Objective: To explore the value of ultrahigh b-value DWI in diagnosis of prostate cancer. Methods: From October 2015 to October 2016, a total of 84 cases from Affiliated Changshu Hospital of Soochow University(39 cases of prostate cancer with a total of 57 lesions, 45 cases of benign prostate hyperplasia) were examined with T(2)WI, high b-value DWI (b=1 000 s/mm(2)) and ultrahigh b-value DWI (b=2 000 s/mm(2)) .Three image sets were rated respectively based on PI-RADS V2 by two radiologists and the scores were compared with biopsy results.The differences of the area under the ROC curve (AUC) among the three groups of each observer were compared by Z test. Results: The difference of AUC between ultrahigh b-value DWI and T(2)WI in the diagnosis of peripheral and transitional zone cancer was statistically significant between the two observers ( P =0.009 9, 0.008 2, 0.010 8 and 0.004 5 respectively), and there was no significant difference of AUC between ultrahigh b-value DWI and high b-value DWI in the diagnosis of peripheral and transitional zone cancer.The inter-reader agreement was found to be perfect for all lesions, peripheral zone lesions and transition zone lesions at ultrahigh b-value DWI ( kappa values were 0.738, 0.709 and 0.768 respectively). Conclusion: The diagnostic performance of ultrahigh b-value DWI is superior to high b-value DWI and T(2)WI in both peripheral zone and transition zone cancers.

Recent developments in novel freezing and thawing technologies applied to foods.

PubMed

Wu, Xiao-Fei; Zhang, Min; Adhikari, Benu; Sun, Jincai

2017-11-22

This article reviews the recent developments in novel freezing and thawing technologies applied to foods. These novel technologies improve the quality of frozen and thawed foods and are energy efficient. The novel technologies applied to freezing include pulsed electric field pre-treatment, ultra-low temperature, ultra-rapid freezing, ultra-high pressure and ultrasound. The novel technologies applied to thawing include ultra-high pressure, ultrasound, high voltage electrostatic field (HVEF), and radio frequency. Ultra-low temperature and ultra-rapid freezing promote the formation and uniform distribution of small ice crystals throughout frozen foods. Ultra-high pressure and ultrasound assisted freezing are non-thermal methods and shorten the freezing time and improve product quality. Ultra-high pressure and HVEF thawing generate high heat transfer rates and accelerate the thawing process. Ultrasound and radio frequency thawing can facilitate thawing process by volumetrically generating heat within frozen foods. It is anticipated that these novel technologies will be increasingly used in food industries in the future.

Fetal exposure to low frequency electric and magnetic fields

NASA Astrophysics Data System (ADS)

Cech, R.; Leitgeb, N.; Pediaditis, M.

2007-02-01

To investigate the interaction of low frequency electric and magnetic fields with pregnant women and in particular with the fetus, an anatomical voxel model of an 89 kg woman at week 30 of pregnancy was developed. Intracorporal electric current density distributions due to exposure to homogeneous 50 Hz electric and magnetic fields were calculated and results were compared with basic restrictions recommended by ICNIRP guidelines. It could be shown that the basic restriction is met within the central nervous system (CNS) of the mother at exposure to reference level of either electric or magnetic fields. However, within the fetus the basic restriction is considerably exceeded. Revision of reference levels might be necessary.

Fractional kinetics of glioma treatment by a radio-frequency electric field

NASA Astrophysics Data System (ADS)

Iomin, A.

2013-09-01

A realistic model for estimation of the medical effect of brain cancer (glioma) treatment by a radio-frequency (RF) electric field is suggested. This low intensity, intermediate-frequency alternating electric field is known as the tumor-treating field (TTF). The model is based on a construction of 3D comb model for a description of the cancer cells dynamics, where the migration-proliferation dichotomy becomes naturally apparent, and the outer-invasive region of glioma cancer is considered as a fractal composite embedded in the 3D space. In the framework of this model, the interplay between the TTF and the migration-proliferation dichotomy of cancer cells is considered, and the efficiency of this TTF is estimated. It is shown that the efficiency of the medical treatment by the TTF depends essentially on the mass fractal dimension of the cancer in the outer-invasive region.

Ultrahigh piezoelectricity in ferroelectric ceramics by design

NASA Astrophysics Data System (ADS)

Li, Fei; Lin, Dabin; Chen, Zibin; Cheng, Zhenxiang; Wang, Jianli; Li, ChunChun; Xu, Zhuo; Huang, Qianwei; Liao, Xiaozhou; Chen, Long-Qing; Shrout, Thomas R.; Zhang, Shujun

2018-03-01

Piezoelectric materials, which respond mechanically to applied electric field and vice versa, are essential for electromechanical transducers. Previous theoretical analyses have shown that high piezoelectricity in perovskite oxides is associated with a flat thermodynamic energy landscape connecting two or more ferroelectric phases. Here, guided by phenomenological theories and phase-field simulations, we propose an alternative design strategy to commonly used morphotropic phase boundaries to further flatten the energy landscape, by judiciously introducing local structural heterogeneity to manipulate interfacial energies (that is, extra interaction energies, such as electrostatic and elastic energies associated with the interfaces). To validate this, we synthesize rare-earth-doped Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT), as rare-earth dopants tend to change the local structure of Pb-based perovskite ferroelectrics. We achieve ultrahigh piezoelectric coefficients d33 of up to 1,500 pC N-1 and dielectric permittivity ɛ33/ɛ0 above 13,000 in a Sm-doped PMN-PT ceramic with a Curie temperature of 89 °C. Our research provides a new paradigm for designing material properties through engineering local structural heterogeneity, expected to benefit a wide range of functional materials.

Ultrahigh piezoelectricity in ferroelectric ceramics by design.

PubMed

Li, Fei; Lin, Dabin; Chen, Zibin; Cheng, Zhenxiang; Wang, Jianli; Li, ChunChun; Xu, Zhuo; Huang, Qianwei; Liao, Xiaozhou; Chen, Long-Qing; Shrout, Thomas R; Zhang, Shujun

2018-04-01

Piezoelectric materials, which respond mechanically to applied electric field and vice versa, are essential for electromechanical transducers. Previous theoretical analyses have shown that high piezoelectricity in perovskite oxides is associated with a flat thermodynamic energy landscape connecting two or more ferroelectric phases. Here, guided by phenomenological theories and phase-field simulations, we propose an alternative design strategy to commonly used morphotropic phase boundaries to further flatten the energy landscape, by judiciously introducing local structural heterogeneity to manipulate interfacial energies (that is, extra interaction energies, such as electrostatic and elastic energies associated with the interfaces). To validate this, we synthesize rare-earth-doped Pb(Mg 1/3 Nb 2/3 )O 3 -PbTiO 3 (PMN-PT), as rare-earth dopants tend to change the local structure of Pb-based perovskite ferroelectrics. We achieve ultrahigh piezoelectric coefficients d 33 of up to 1,500 pC N -1 and dielectric permittivity ε 33 /ε 0 above 13,000 in a Sm-doped PMN-PT ceramic with a Curie temperature of 89 °C. Our research provides a new paradigm for designing material properties through engineering local structural heterogeneity, expected to benefit a wide range of functional materials.

Design Method For Ultra-High Resolution Linear CCD Imagers

NASA Astrophysics Data System (ADS)

Sheu, Larry S.; Truong, Thanh; Yuzuki, Larry; Elhatem, Abdul; Kadekodi, Narayan

1984-11-01

This paper presents the design method to achieve ultra-high resolution linear imagers. This method utilizes advanced design rules and novel staggered bilinear photo sensor arrays with quadrilinear shift registers. Design constraint in the detector arrays and shift registers are analyzed. Imager architecture to achieve ultra-high resolution is presented. The characteristics of MTF, aliasing, speed, transfer efficiency and fine photolithography requirements associated with this architecture are also discussed. A CCD imager with advanced 1.5 um minimum feature size was fabricated. It is intended as a test vehicle for the next generation small sampling pitch ultra-high resolution CCD imager. Standard double-poly, two-phase shift registers were fabricated at an 8 um pitch using the advanced design rules. A special process step that blocked the source-drain implant from the shift register area was invented. This guaranteed excellent performance of the shift registers regardless of the small poly overlaps. A charge transfer efficiency of better than 0.99995 and maximum transfer speed of 8 MHz were achieved. The imager showed excellent performance. The dark current was less than 0.2 mV/ms, saturation 250 mV, adjacent photoresponse non-uniformity ± 4% and responsivity 0.7 V/ μJ/cm2 for the 8 μm x 6 μm photosensor size. The MTF was 0.6 at 62.5 cycles/mm. These results confirm the feasibility of the next generation ultra-high resolution CCD imagers.

High frequency source localization in a shallow ocean sound channel using frequency difference matched field processing.

PubMed

Worthmann, Brian M; Song, H C; Dowling, David R

2015-12-01

Matched field processing (MFP) is an established technique for source localization in known multipath acoustic environments. Unfortunately, in many situations, particularly those involving high frequency signals, imperfect knowledge of the actual propagation environment prevents accurate propagation modeling and source localization via MFP fails. For beamforming applications, this actual-to-model mismatch problem was mitigated through a frequency downshift, made possible by a nonlinear array-signal-processing technique called frequency difference beamforming [Abadi, Song, and Dowling (2012). J. Acoust. Soc. Am. 132, 3018-3029]. Here, this technique is extended to conventional (Bartlett) MFP using simulations and measurements from the 2011 Kauai Acoustic Communications MURI experiment (KAM11) to produce ambiguity surfaces at frequencies well below the signal bandwidth where the detrimental effects of mismatch are reduced. Both the simulation and experimental results suggest that frequency difference MFP can be more robust against environmental mismatch than conventional MFP. In particular, signals of frequency 11.2 kHz-32.8 kHz were broadcast 3 km through a 106-m-deep shallow ocean sound channel to a sparse 16-element vertical receiving array. Frequency difference MFP unambiguously localized the source in several experimental data sets with average peak-to-side-lobe ratio of 0.9 dB, average absolute-value range error of 170 m, and average absolute-value depth error of 10 m.

Field optimization method of a dual-axis atomic magnetometer based on frequency-response and dynamics

NASA Astrophysics Data System (ADS)

Xing, Li; Quan, Wei; Fan, Wenfeng; Li, Rujie; Jiang, Liwei; Fang, Jiancheng

2018-05-01

The frequency-response and dynamics of a dual-axis spin-exchange-relaxation-free (SERF) atomic magnetometer are investigated by means of transfer function analysis. The frequency-response at different bias magnetic fields is tested to demonstrate the effect of the residual magnetic field. The resonance frequency of alkali atoms and magnetic linewidth can be obtained simultaneously through our theoretical model. The coefficient of determination of the fitting results is superior to 0.995 with 95% confidence bounds. Additionally, step responses are applied to analyze the dynamics of the control system and the effect of imperfections. Finally, a noise-limited magnetic field resolution of 15 fT {{\\sqrt{Hz}}-1} has been achieved for our dual-axis SERF atomic magnetometer through magnetic field optimization.

Electrochemical growth of Co nanowires in ultra-high aspect ratio InP membranes: FFT-impedance spectroscopy of the growth process and magnetic properties.

PubMed

Gerngross, Mark-Daniel; Carstensen, Jürgen; Föll, Helmut

2014-01-01

The electrochemical growth of Co nanowires in ultra-high aspect ratio InP membranes has been investigated by fast Fourier transform-impedance spectroscopy (FFT-IS) in the frequency range from 75 Hz to 18.5 kHz. The impedance data could be fitted very well using an electric circuit equivalent model with a series resistance connected in series to a simple resistor-capacitor (RC) element and a Maxwell element. Based on the impedance data, the Co deposition in ultra-high aspect ratio InP membranes can be divided into two different Co deposition processes. The corresponding share of each process on the overall Co deposition can be determined directly from the transfer resistances of the two processes. The impedance data clearly show the beneficial impact of boric acid on the Co deposition and also indicate a diffusion limitation of boric acid in ultra-high aspect ratio InP membranes. The grown Co nanowires are polycrystalline with a very small grain size. They show a narrow hysteresis loop with a preferential orientation of the easy magnetization direction along the long nanowire axis due to the arising shape anisotropy of the Co nanowires.

High-frequency field-deployable isotope analyzer for hydrological applications

Treesearch

Elena S.F. Berman; Manish Gupta; Chris Gabrielli; Tina Garland; Jeffrey J. McDonnell

2009-01-01

A high-frequency, field-deployable liquid water isotope analyzer was developed. The instrument was deployed for 4 contiguous weeks in the H. J. Andrews Experimental Forest Long-term Ecological Research site in western Oregon, where it was used for real-time measurement of the isotope ratios of precipitation and stream water during three large storm events. We were able...

Efficient Ultra-High Speed Communication with Simultaneous Phase and Amplitude Regenerative Sampling (SPARS)

NASA Astrophysics Data System (ADS)

Carlowitz, Christian; Girg, Thomas; Ghaleb, Hatem; Du, Xuan-Quang

2017-09-01

For ultra-high speed communication systems at high center frequencies above 100 GHz, we propose a disruptive change in system architecture to address major issues regarding amplifier chains with a large number of amplifier stages. They cause a high noise figure and high power consumption when operating close to the frequency limits of the underlying semiconductor technologies. Instead of scaling a classic homodyne transceiver system, we employ repeated amplification in single-stage amplifiers through positive feedback as well as synthesizer-free self-mixing demodulation at the receiver to simplify the system architecture notably. Since the amplitude and phase information for the emerging oscillation is defined by the input signal and the oscillator is only turned on for a very short time, it can be left unstabilized and thus come without a PLL. As soon as gain is no longer the most prominent issue, relaxed requirements for all the other major components allow reconsidering their implementation concepts to achieve further improvements compared to classic systems. This paper provides the first comprehensive overview of all major design aspects that need to be addressed upon realizing a SPARS-based transceiver. At system level, we show how to achieve high data rates and a noise performance comparable to classic systems, backed by scaled demonstrator experiments. Regarding the transmitter, design considerations for efficient quadrature modulation are discussed. For the frontend components that replace PA and LNA amplifier chains, implementation techniques for regenerative sampling circuits based on super-regenerative oscillators are presented. Finally, an analog-to-digital converter with outstanding performance and complete interfaces both to the analog baseband as well as to the digital side completes the set of building blocks for efficient ultra-high speed communication.

Effect of low frequency magnetic fields on the growth of MNP-treated HT29 colon cancer cells

NASA Astrophysics Data System (ADS)

Spyridopoulou, K.; Makridis, A.; Maniotis, N.; Karypidou, N.; Myrovali, E.; Samaras, T.; Angelakeris, M.; Chlichlia, K.; Kalogirou, O.

2018-04-01

Recent investigations have attempted to understand and exploit the impact of magnetic field-actuated internalized magnetic nanoparticles (MNPs) on the proliferation rate of cancer cells. Due to the complexity of the parameters governing magnetic field-exposure though, individual studies to date have raised contradictory results. In our approach we performed a comparative analysis of key parameters related to the cell exposure of cancer cells to magnetic field-actuated MNPs, and to the magnetic field, in order to better understand the factors affecting cellular responses to magnetic field-stimulated MNPs. We used magnetite MNPs with a hydrodynamic diameter of 100 nm and studied the proliferation rate of MNPs-treated versus untreated HT29 human colon cancer cells, exposed to either static or alternating low frequency magnetic fields with varying intensity (40-200 mT), frequency (0-8 Hz) and field gradient. All three parameters, field intensity, frequency, and field gradient affected the growth rate of cells, with or without internalized MNPs, as compared to control MNPs-untreated and magnetic field-untreated cells. We observed that the growth inhibitory effects induced by static and rotating magnetic fields were enhanced by pre-treating the cells with MNPs, while the growth promoting effects observed in alternating field-treated cells were weakened by MNPs. Compared to static, rotating magnetic fields of the same intensity induced a similar extend of cell growth inhibition, while alternating fields of varying intensity (70 or 100 mT) and frequency (0, 4 or 8 Hz) induced cell proliferation in a frequency-dependent manner. These results, highlighting the diverse effects of mode, intensity, and frequency of the magnetic field on cell growth, indicate that consistent and reproducible results can be achieved by controlling the complexity of the exposure of biological samples to MNPs and external magnetic fields, through monitoring crucial experimental parameters. We

Detection of Ultrahigh-Energy Cosmic Rays with the Auger Engineering Radio Array

NASA Astrophysics Data System (ADS)

Krause, Raphael; Pierre Auger Collaboration

2017-02-01

Ultrahigh-energy cosmic rays interact with the Earth's atmosphere and produce great numbers of secondary particles forming an extensive air shower. These air showers emit radiation in the radio frequency range which delivers important information about the processes of radio emission in extensive air showers and properties of the primary cosmic rays, e.g. arrival direction, energy and mass with a duty cycle close to 100%. The radio extension of the world's largest cosmic-ray experiment, the Pierre Auger Observatory, is called the Auger Engineering Radio Array (AERA). In addition to the particle and fluorescence detectors of the Pierre Auger Observatory, AERA investigates the electromagnetic component of extensive air showers using 153 autonomous radio stations on an area of 17km2 .

High-frequency analysis of Earth gravity field models based on terrestrial gravity and GPS/levelling data: a case study in Greece

NASA Astrophysics Data System (ADS)

Papanikolaou, T. D.; Papadopoulos, N.

2015-06-01

The present study aims at the validation of global gravity field models through numerical investigation in gravity field functionals based on spherical harmonic synthesis of the geopotential models and the analysis of terrestrial data. We examine gravity models produced according to the latest approaches for gravity field recovery based on the principles of the Gravity field and steadystate Ocean Circulation Explorer (GOCE) and Gravity Recovery And Climate Experiment (GRACE) satellite missions. Furthermore, we evaluate the overall spectrum of the ultra-high degree combined gravity models EGM2008 and EIGEN-6C3stat. The terrestrial data consist of gravity and collocated GPS/levelling data in the overall Hellenic region. The software presented here implements the algorithm of spherical harmonic synthesis in a degree-wise cumulative sense. This approach may quantify the bandlimited performance of the individual models by monitoring the degree-wise computed functionals against the terrestrial data. The degree-wise analysis performed yields insight in the short-wavelengths of the Earth gravity field as these are expressed by the high degree harmonics.

Frequency-dependent electrodeformation of giant phospholipid vesicles in AC electric field

PubMed Central

2010-01-01

A model of vesicle electrodeformation is described which obtains a parametrized vesicle shape by minimizing the sum of the membrane bending energy and the energy due to the electric field. Both the vesicle membrane and the aqueous media inside and outside the vesicle are treated as leaky dielectrics, and the vesicle itself is modeled as a nearly spherical shape enclosed within a thin membrane. It is demonstrated (a) that the model achieves a good quantitative agreement with the experimentally determined prolate-to-oblate transition frequencies in the kilohertz range and (b) that the model can explain a phase diagram of shapes of giant phospholipid vesicles with respect to two parameters: the frequency of the applied alternating current electric field and the ratio of the electrical conductivities of the aqueous media inside and outside the vesicle, explored in a recent paper (S. Aranda et al., Biophys J 95:L19–L21, 2008). A possible use of the frequency-dependent shape transitions of phospholipid vesicles in conductometry of microliter samples is discussed. PMID:21886342

Field camera measurements of gradient and shim impulse responses using frequency sweeps.

PubMed

Vannesjo, S Johanna; Dietrich, Benjamin E; Pavan, Matteo; Brunner, David O; Wilm, Bertram J; Barmet, Christoph; Pruessmann, Klaas P

2014-08-01

Applications of dynamic shimming require high field fidelity, and characterizing the shim field dynamics is therefore necessary. Modeling the system as linear and time-invariant, the purpose of this work was to measure the impulse response function with optimal sensitivity. Frequency-swept pulses as inputs are analyzed theoretically, showing that the sweep speed is a key factor for the measurement sensitivity. By adjusting the sweep speed it is possible to achieve any prescribed noise profile in the measured system response. Impulse response functions were obtained for the third-order shim system of a 7 Tesla whole-body MR scanner. Measurements of the shim fields were done with a dynamic field camera, yielding also cross-term responses. The measured shim impulse response functions revealed system characteristics such as response bandwidth, eddy currents and specific resonances, possibly of mechanical origin. Field predictions based on the shim characterization were shown to agree well with directly measured fields, also in the cross-terms. Frequency sweeps provide a flexible tool for shim or gradient system characterization. This may prove useful for applications involving dynamic shimming by yielding accurate estimates of the shim fields and a basis for setting shim pre-emphasis. Copyright © 2013 Wiley Periodicals, Inc.

Radio-frequency and microwave energies, magnetic and electric fields

NASA Technical Reports Server (NTRS)

Michaelson, S. M.

1975-01-01

The biological effects of radio frequency, including microwave, radiation are considered. Effects on body temperature, the eye, reproductive systems, internal organs, blood cells, the cardiovascular system, and the central nervous system are included. Generalized effects of electric and magnetic fields are also discussed. Experimentation with animals and clinical studies on humans are cited, and possible mechanisms of the effects observed are suggested.

Ultrahigh-rate supercapacitors with large capacitance based on edge oriented graphene coated carbonized cellulous paper as flexible freestanding electrodes

NASA Astrophysics Data System (ADS)

Ren, Guofeng; Li, Shiqi; Fan, Zhao-Xia; Hoque, Md Nadim Ferdous; Fan, Zhaoyang

2016-09-01

Large-capacitance and ultrahigh-rate electrochemical supercapacitors (UECs) with frequency response up to kilohertz (kHz) range are reported using light, thin, and flexible freestanding electrodes. The electrode is formed by perpendicularly edge oriented multilayer graphene/thin-graphite (EOG) sheets grown radially around individual fibers in carbonized cellulous paper (CCP), with cellulous carbonization and EOG deposition implemented in one step. The resulted ∼10 μm thick EOG/CCP electrode is light and flexible. The oriented porous structure of EOG with large surface area, in conjunction with high conductivity of the electrode, ensures ultrahigh-rate performance of the fabricated cells, with large areal capacitance of 0.59 mF cm-2 and 0.53 mF cm-2 and large phase angle of -83° and -80° at 120 Hz and 1 kHz, respectively. Particularly, the hierarchical EOG/CCP sheet structure allows multiple sheets stacked together for thick electrodes with almost linearly increased areal capacitance while maintaining the volumetric capacitance nearly no degradation, a critical merit for developing practical faraday-scale UECs. 3-layers of EOG/CCP electrode achieved an areal capacitance of 1.5 mF cm-2 and 1.4 mF cm-2 at 120 Hz and 1 kHz, respectively. This demonstration moves a step closer to the goal of bridging the frequency/capacitance gap between supercapacitors and electrolytic capacitors.

AC electric field induced dielectrophoretic assembly behavior of gold nanoparticles in a wide frequency range

NASA Astrophysics Data System (ADS)

Liu, Weiyu; Wang, Chunhui; Ding, Haitao; Shao, Jinyou; Ding, Yucheng

2016-05-01

In this work, we focus on frequency-dependence of pearl chain formations (PCF) of gold nanoparticles driven by AC dielectrophoresis (DEP), especially in a low field-frequency range, where induced double-layer charging effect at ideally polarizable surfaces on particle DEP behavior and surrounding liquid motion need not be negligible. As field frequency varies, grown features of DEP assembly structures ranging from low-frequency non-bridged gap to high-frequency single gold nanoparticle-made nanowires bridging the electrodes are demonstrated experimentally. Specifically, at 10 kHz, a kind of novel channel-like structure with parallel opposing banks is formed at the center of interelectrode gap. In stark contrast, at 1 MHz, thin PCF with diameter of 100 nm is created along the shortest distance of the isolation spacing. Moreover, a particular conductive path of nanoparticle chains is produced at 1 MHz in a DEP device embedded with multiple floating electrodes. A theoretical framework taking into account field-induced double-layer polarization at both the particle/electrolyte and electrode/electrolyte interface is developed to correlate these experimental observations with induced-charge electrokinetic (ICEK) phenomenon. And a RC circuit model is helpful in accounting for the formation of this particular non-bridged channel-like structure induced by a low-frequency AC voltage. As compared to thin PCF formed at high field frequency that effectively short circuits the electrode pair, though it is difficult for complete PCF bridging to occur at low frequency, the non-bridged conducting microstructure has potential to further miniaturize the size of electrode gap fabricated by standard micromachining process and may find useful application in biochemical sensing.

Ultra-high sensitivity Fabry-Perot interferometer gas refractive index fiber sensor based on photonic crystal fiber and Vernier effect.

PubMed

Quan, Mingran; Tian, Jiajun; Yao, Yong

2015-11-01

An ultra-high sensitivity open-cavity Fabry-Perot interferometer (FPI) gas refractive index (RI) sensor based on the photonic crystal fiber (PCF) and Vernier effect is proposed and demonstrated. The sensor is prepared by splicing a section of PCF to a section of fiber tube fused with a section of single mode fiber. The air holes running along the cladding of the PCF enable the gas to enter or leave the cavity freely. The reflection beam from the last end face of the PCF is used to generate the Vernier effect, which significantly improves the sensitivity of the sensor. Experimental results show that the proposed sensor can provide an ultra-high RI sensitivity of 30899 nm/RIU. This sensor has potential applications in fields such as gas concentration analyzing and humidity monitoring.

Feature Screening for Ultrahigh Dimensional Categorical Data with Applications.

PubMed

Huang, Danyang; Li, Runze; Wang, Hansheng

2014-01-01

Ultrahigh dimensional data with both categorical responses and categorical covariates are frequently encountered in the analysis of big data, for which feature screening has become an indispensable statistical tool. We propose a Pearson chi-square based feature screening procedure for categorical response with ultrahigh dimensional categorical covariates. The proposed procedure can be directly applied for detection of important interaction effects. We further show that the proposed procedure possesses screening consistency property in the terminology of Fan and Lv (2008). We investigate the finite sample performance of the proposed procedure by Monte Carlo simulation studies, and illustrate the proposed method by two empirical datasets.

Effect of Nb on Delayed Fracture Resistance of Ultra-High Strength Martensitic Steels

NASA Astrophysics Data System (ADS)

Song, Rongjie; Fonstein, Nina; Pottore, Narayan; Jun, Hyun Jo; Bhattacharya, Debanshu; Jansto, Steve

Ultra-high strength steels are materials of considerable interest for automotive and structural applications and are increasingly being used in those areas. Higher strength, however, makes steels more prone to hydrogen embrittlement (HE). The effects of Nb and other alloying elements on the hydrogen-induced delayed fracture resistance of cold rolled martensitic steels with ultra-high strength 2000 MPa were studied using an acid immersion test, thermal desorption analysis (TDA) and measuring of permeation. The microstructure was characterized by high resolution field emission Scanning Electron Microscopy (SEM) with Electron Backscattered Diffraction (EBSD) and Transmission Electron Microscopy (TEM). It was shown that the combined addition of Nb significantly improved the delayed fracture resistance of investigated steel. The addition of Nb to alloyed martensitic steels resulted in very apparent grain refinement of the prior austenite grain size. The Nb microalloyed steel contained a lower diffusible hydrogen content during thermal desorption analysis as compared to the base steel and had a higher trapped hydrogen amount after charging. The reason that Nb improved the delayed fracture resistance of steels can be attributed mostly to both hydrogen trapping and grain refinement.

Dynamic blocked transfer stiffness method of characterizing the magnetic field and frequency dependent dynamic viscoelastic properties of MRE

NASA Astrophysics Data System (ADS)

Poojary, Umanath R.; Hegde, Sriharsha; Gangadharan, K. V.

2016-11-01

Magneto rheological elastomer (MRE) is a potential resilient element for the semi active vibration isolator. MRE based isolators adapt to different frequency of vibrations arising from the source to isolate the structure over wider frequency range. The performance of MRE isolator depends on the magnetic field and frequency dependent characteristics of MRE. Present study is focused on experimentally evaluating the dynamic stiffness and loss factor of MRE through dynamic blocked transfer stiffness method. The dynamic stiffness variations of MRE exhibit strong magnetic field and mild frequency dependency. Enhancements in dynamic stiffness saturate with the increase in magnetic field and the frequency. The inconsistent variations of loss factor with the magnetic field substantiate the inability of MRE to have independent control over its damping characteristics.

Ultrahigh vacuum gauge having two collector electrodes

NASA Technical Reports Server (NTRS)

Torney, F. L., Jr. (Inventor)

1967-01-01

A gauge for measuring ultrahigh vacuums with great accuracy is described. It provides a means for ionizing the gas whose pressure is being measured, and consists of a collector electrode, a suppressor, radiation shielding, and a second collector.

Acute neuroprotective effects of extremely low-frequency electromagnetic fields after traumatic brain injury in rats.

PubMed

Yang, Yang; Li, Ling; Wang, Yan-Gang; Fei, Zhou; Zhong, Jun; Wei, Li-Zhou; Long, Qian-Fa; Liu, Wei-Ping

2012-05-10

Traumatic brain injury commonly has a result of a short window of opportunity between the period of initial brain injury and secondary brain injury, which provides protective strategies and can reduce damages of brain due to secondary brain injury. Previous studies have reported neuroprotective effects of extremely low-frequency electromagnetic fields. However, the effects of extremely low-frequency electromagnetic fields on neural damage after traumatic brain injury have not been reported yet. The present study aims to investigate effects of extremely low-frequency electromagnetic fields on neuroprotection after traumatic brain injury. Male Sprague-Dawley rats were used for the model of lateral fluid percussion injury, which were placed in non-electromagnetic fields and 15 Hz (Hertz) electromagnetic fields with intensities of 1 G (Gauss), 3 G and 5 G. At various time points (ranging from 0.5 to 30 h) after lateral fluid percussion injury, rats were treated with kainic acid (administered by intraperitoneal injection) to induce apoptosis in hippocampal cells. The results were as follows: (1) the expression of hypoxia-inducible factor-1α was dramatically decreased during the neuroprotective time window. (2) The kainic acid-induced apoptosis in the hippocampus was significantly decreased in rats exposed to electromagnetic fields. (3) Electromagnetic fields exposure shortened the escape time in water maze test. (4) Electromagnetic fields exposure accelerated the recovery of the blood-brain barrier after brain injury. These findings revealed that extremely low-frequency electromagnetic fields significantly prolong the window of opportunity for brain protection and enhance the intensity of neuroprotection after traumatic brain injury. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

[Design of MC-III low frequency pulsed strong magnetic fields generator].

PubMed

Wen, Jun; Zhong, Lisheng; Xie, Hengkun; Qu, Xuemin; Ju, Hongbo; Yang, Jiqing; Wang, Sigang

2002-12-01

In this paper, We designed and accomplished a low frequency pulsed strong magnetic fields generator, which provides a pulsed magnetic field with the intensity range from 0.1-2.5 T and the adjusted time interval of pulse. This device is easy to operate and performs reliably. It can work steady for a long time and has been successful used in the experiments of biological effects of electromagnetics.

Exposure assessment of extremely low frequency electric fields in Tehran, Iran, 2010.

PubMed

Nassiri, Parvin; Esmaeilpour, Mohammad Reza Monazzam; Gharachahi, Ehsan; Haghighat, Gholamali; Yunesian, Masoud; Zaredar, Narges

2013-01-01

Extremely Low-Frequency (ELF) electric and magnetic fields belonging to the nonionizing electromagnetic radiation spectrum have a frequency of 50 - 60 Hz. All people are exposed to a complex set of electric and magnetic fields that spread throughout the environment. The current study was carried out to assess people's exposure to an ELF electric field in the Tehran metropolitan area in 2010. The measurement of the electronic fields was performed using an HI-3604 power frequency field strength measurement device. A total number of 2,753 measurements were performed. Afterward, the data obtained were transferred to the base map using Arc View Version 3.2 and Arc Map Version 9.3. Finally, an interpolation method was applied to expand the intensity of the electric field to the entire city. Based on the results obtained, the electric field was divided into three parts with various intensities including 0-5 V m, 5-15 V m, and >15 V m. It should be noted that the status of high voltage transmission lines, electric substations, and specific points including schools and hospitals were also marked on the map. Minimum and maximum electric field intensities were measured tantamount to 0.31 V m and 19.80 V m, respectively. In all measurements, the electric field was much less than the amount provided in the ICNIRP Guide. The results revealed that 141 hospitals and 6,905 schools are situated in an area with electric field intensity equal to 0-5 V m, while 15 hospitals and 95 schools are located in zones of 5-15 V m and more than 15 V m. Examining high voltage transmission lines and electric substations in Tehran and its suburbs suggested that the impact of the lines on the background electric field of the city was low. Accordingly, 0.97 km of Tehran located on the city border adjacent to the high voltage transmission lines have an electric field in the range of 5 to 15 V m. The noted range is much lower than the available standards. In summary, it can be concluded that the public

A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field.

PubMed

Cronin, Matthew John; Wharton, Samuel; Al-Radaideh, Ali; Constantinescu, Cris; Evangelou, Nikos; Bowtell, Richard; Gowland, Penny Anne

2016-06-01

The aim of this study was to compare the use of high-resolution phase and QSM images acquired at ultra-high field in the investigation of multiple sclerosis (MS) lesions with peripheral rings, and to discuss their usefulness for drawing inferences about underlying tissue composition. Thirty-nine Subjects were scanned at 7 T, using 3D T 2*-weighted and T 1-weighted sequences. Phase images were then unwrapped and filtered, and quantitative susceptibility maps were generated using a thresholded k-space division method. Lesions were compared visually and using a 1D profiling algorithm. Lesions displaying peripheral rings in the phase images were identified in 10 of the 39 subjects. Dipolar projections were apparent in the phase images outside of the extent of several of these lesions; however, QSM images showed peripheral rings without such projections. These projections appeared ring-like in a small number of phase images where no ring was observed in QSM. 1D profiles of six well-isolated example lesions showed that QSM contrast corresponds more closely to the magnitude images than phase contrast. Phase images contain dipolar projections, which confounds their use in the investigation of tissue composition in MS lesions. Quantitative susceptibility maps correct these projections, providing insight into the composition of MS lesions showing peripheral rings.

Ultrahigh-speed Si-integrated on-chip laser with tailored dynamic characteristics

NASA Astrophysics Data System (ADS)

Park, Gyeong Cheol; Xue, Weiqi; Piels, Molly; Zibar, Darko; Mørk, Jesper; Semenova, Elizaveta; Chung, Il-Sug

2016-12-01

For on-chip interconnects, an ideal light source should have an ultralow energy consumption per bandwidth (operating en-ergy) as well as sufficient output power for error-free detection. Nanocavity lasers have been considered the most ideal for smaller operating energy. However, they have a challenge in obtaining a sufficient output power. Here, as an alternative, we propose an ultrahigh-speed microcavity laser structure, based on a vertical cavity with a high-contrast grating (HCG) mirror for transverse magnetic (TM) polarisation. By using the TM HCG, a very small mode volume and an un-pumped compact optical feedback structure can be realised, which together tailor the frequency response function for achieving a very high speed at low injection currents. Furthermore, light can be emitted laterally into a Si waveguide. From an 1.54-μm optically-pumped laser, a 3-dB frequency of 27 GHz was obtained at a pumping level corresponding to sub-mA. Using measured 3-dB frequen-cies and calculated equivalent currents, the modulation current efficiency factor (MCEF) is estimated to be 42.1 GHz/mA1/2, which is superior among microcavity lasers. This shows a high potential for a very high speed at low injection currents or avery small heat generation at high bitrates, which are highly desirable for both on-chip and off-chip applications.

Study of magnetic fields from power-frequency current on water lines.

PubMed

Lanera, D; Zapotosky, J E; Colby, J A

1997-01-01

The magnetic fields from power-frequency current flowing on water lines were investigated in a new approach that involved an area-wide survey in a small town. Magnetic fields were measured outside the residence under power cables and over water lines, and each residence was characterized as to whether it received water from a private well or the municipal water system. The magnetic field data revealed two statistical modes when they were related to water supply type. The data also showed that in the case of the high mode, the magnetic field remained constant along the line formed by power drop wires, at the back of the house, and the water hookup service, in front of the house, all the way to the street. The patterns are explained by the coincidence of measurement points and the presence of net current flowing on power mains, power drop conductors, residential plumbing, water service hookups, and water mains. These patterns, together with other characteristics of this magnetic field source, such as the gradual spatial fall-off of this field and the presence of a constant component in the time sequence, portray a magnetic field more uniform and constant in the residential environment than has been thought to exist. Such characteristics make up for the weakness of the source and make net current a significant source of exposure in the lives of individuals around the house, when human exposure to magnetic fields is assumed to be a cumulative effect over time. This, together with the bimodal statistical distribution of the residential magnetic field (related to water supply type), presents opportunities for retrospective epidemiological analysis. Water line type and its ability to conduct power-frequency current can be used as the historical marker for a bimodal exposure inference, as Wertheimer et al. have shown.

Ultrahigh-Resolution Optical Coherence Tomography of Surgically Closed Macular Holes

PubMed Central

Ko, Tony H.; Witkin, Andre J.; Fujimoto, James G.; Chan, Annie; Rogers, Adam H.; Baumal, Caroline R.; Schuman, Joel S.; Drexler, Wolfgang; Reichel, Elias; Duker, Jay S.

2007-01-01

Objective To evaluate retinal anatomy using ultrahigh-resolution optical coherence tomography (OCT) in eyes after successful surgical repair of full-thickness macular hole. Methods Twenty-two eyes of 22 patients were diagnosed as having macular hole, underwent pars plana vitrectomy, and had flat/closed macular anatomy after surgery, as confirmed with biomicroscopic and OCT examination findings. An ultrahigh-resolution–OCT system developed for retinal imaging, with the capability to achieve approximately 3-μm axial resolution, was used to evaluate retinal anatomy after hole repair. Results Despite successful closure of the macular hole, all 22 eyes had macular abnormalities on ultrahigh-resolution–OCT images after surgery. These abnormalities were separated into the following 5 categories: (1) outer foveal defects in 14 eyes (64%), (2) persistent foveal detachment in 4 (18%), (3) moderately reflective foveal lesions in 12 (55%), (4) epiretinal membranes in 14 (64%), and (5) nerve fiber layer defects in 3 (14%). Conclusions With improved visualization of fine retinal architectural features, ultrahigh-resolution OCT can visualize persistent retinal abnormalities despite anatomically successful macular hole surgery. Outer foveal hyporeflective disruptions of the junction between the inner and outer segments of the photoreceptors likely represent areas of foveal photoreceptor degeneration. Moderately reflective lesions likely represent glial cell proliferation at the site of hole reapproximation. Thin epiretinal membranes do not seem to decrease visual acuity and may play a role in reestablishing foveal anatomy after surgery. PMID:16769836

Frequency dependence of the acoustic field generated from a spherical cavity transducer with open ends

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Faqi; Zeng, Deping; He, Min

2015-12-15

Resolution of high intensity focused ultrasound (HIFU) focusing is limited by the wave diffraction. We have developed a spherical cavity transducer with two open ends to improve the focusing precision without sacrificing the acoustic intensity (App Phys Lett 2013; 102: 204102). This work aims to theoretically and experimentally investigate the frequency dependence of the acoustic field generated from the spherical cavity transducer with two open ends. The device emits high intensity ultrasound at the frequency ranging from 420 to 470 kHz, and the acoustic field is measured by a fiber optic probe hydrophone. The measured results shows that the sphericalmore » cavity transducer provides high acoustic intensity for HIFU treatment only in its resonant modes, and a series of resonant frequencies can be choosen. Furthermore, a finite element model is developed to discuss the frequency dependence of the acoustic field. The numerical simulations coincide well with the measured results.« less

Ultrahigh contrast from a frequency-doubled chirped-pulse-amplification beamline.

PubMed

Hillier, David; Danson, Colin; Duffield, Stuart; Egan, David; Elsmere, Stephen; Girling, Mark; Harvey, Ewan; Hopps, Nicholas; Norman, Michael; Parker, Stefan; Treadwell, Paul; Winter, David; Bett, Thomas

2013-06-20

This paper describes frequency-doubled operation of a high-energy chirped-pulse-amplification beamline. Efficient type-I second-harmonic generation was achieved using a 3 mm thick 320 mm aperture KDP crystal. Shots were fired at a range of energies achieving more than 100 J in a subpicosecond, 527 nm laser pulse with a power contrast of 10(14).

Low-frequency approximation for high-order harmonic generation by a bicircular laser field

NASA Astrophysics Data System (ADS)

Milošević, D. B.

2018-01-01

We present low-frequency approximation (LFA) for high-order harmonic generation (HHG) process. LFA represents the lowest-order term of an expansion of the final-state interaction matrix element in powers of the laser-field frequency ω . In this approximation the plane-wave recombination matrix element which appears in the strong-field approximation is replaced by the exact laser-free recombination matrix element calculated for the laser-field dressed electron momenta. First, we have shown that the HHG spectra obtained using the LFA agree with those obtained solving the time-dependent Schrödinger equation. Next, we have applied this LFA to calculate the HHG rate for inert gases exposed to a bicircular field. The bicircular field, which consists of two coplanar counter-rotating fields having different frequencies (usually ω and 2 ω ), is presently an important subject of scientific research since it enables efficient generation of circularly polarized high-order harmonics (coherent soft x rays). Analyzing the photorecombination matrix element we have found that the HHG rate can efficiently be calculated using the angular momentum basis with the states oriented in the direction of the bicircular field components. Our numerical results show that the HHG rate for atoms having p ground state, for higher high-order harmonic energies, is larger for circularly polarized harmonics having the helicity -1 . For lower energies the harmonics having helicity +1 prevails. The transition between these two harmonic energy regions can appear near the Cooper minimum, which, in the case of Ar atoms, makes the selection of high-order harmonics having the same helicity much easier. This is important for applications (for example, for generation of attosecond pulse trains of circularly polarized harmonics).

Unusual polarity-dependent patterns in a bent-core nematic liquid crystal under low-frequency ac field.

PubMed

Xiang, Ying; Zhou, Meng-jie; Xu, Ming-Ya; Salamon, Péter; Éber, Nándor; Buka, Ágnes

2015-04-01

Electric-field-induced patterns of diverse morphology have been observed over a wide frequency range in a recently synthesized bent-core nematic (BCN) liquid crystal. At low frequencies (up to ∼25 Hz), the BCN exhibited unusual polarity-dependent patterns. When the amplitude of the ac field was enhanced, these two time-asymmetrical patterns turned into time-symmetrical prewavylike stripes. At ac frequencies in the middle-frequency range (∼50-3000 Hz), zigzag patterns were detected whose obliqueness varied with the frequency. Finally, if the frequency was increased above 3 kHz, the zigzag pattern was replaced by another, prewavylike pattern, whose threshold voltage depended on the frequency; however, the wave vector did not. For a more complete characterization, material parameters such as elastic constants, dielectric permittivities, and the anisotropy of the diamagnetic susceptibility were also determined.

Evaluation of Tumor Treatment of Magnetic Nanoparticles Driven by Extremely Low Frequency Magnetic Field

PubMed Central

Li, Weitao; Liu, Yangyang; Qian, Zhiyu; Yang, Yamin

2017-01-01

Recently, magnetic nanoparticles (MNPs), which can be manipulated in the magnetic field, have received much attention in tumor therapy. Extremely low frequency magnetic field (ELMF) system can initiate MNPs vibrating and the movement of MNPs inside of cells can be controlled by adjusting the frequency and intensity of ELMF towards irreversible cell damages. In this study, we investigated the detrimental effects on tumor cells with MNPs under various ELMF exposure conditions. An in-house built ELMF system was developed and utilized for evaluating the treatment efficiency of MNPs on tumor cells with specific intensities (2–20 Hz) and frequencies (0.1–20 mT). Significant morphological changes were found in tumor cells treated with MNPs in combing with ELMF, which were consistent with noticeable decrease in cell viability. With the increase of the intensity and frequency of the magnetic field, the structural integrity of tumor tissue can be further destroyed. Destructive effects of MNPs and ELMF on tumor tissues were further determined by the pathophysiological changes observed in vivo in animal study. Taken together, the combination of MNPs and ELMF had a great potential as an innovative treatment approach for tumor intervention. PMID:28397790

Bioelectric fields of marine organisms: voltage and frequency contributions to detectability by electroreceptive predators.

PubMed

Bedore, Christine N; Kajiura, Stephen M

2013-01-01

Behavioral responses of elasmobranch fishes to weak electric fields have been well studied. These studies typically employ a stimulator that produces a dipole electric field intended to simulate the natural electric field of prey items. However, the characteristics of bioelectric fields have not been well described. The magnitude and frequency of the electric field produced by 11 families of marine organisms were quantified in this study. Invertebrate electric potentials ranged from 14 to 28 μV and did not differ from those of elasmobranchs, which ranged from 18 to 30 μV. Invertebrates and elasmobranchs produced electric potentials smaller than those of teleost fishes, which ranged from 39 to 319 μV. All species produced electric fields within the frequency range that is detectable by elasmobranch predators (<16 Hz), with the highest frequencies produced by the penaeids (10.3 Hz) and the gerreids (4.6 Hz). Although voltage differed by family, there was no relationship between voltage and mass or length of prey. Differences in prey voltage may be related to osmoregulatory strategies; invertebrates and elasmobranchs are osmoconformers and have less ion exchange with the surrounding seawater than teleosts species, which are hyposmotic. As predicted, voltage production was greatest at the mucous membrane-lined mouth and gills, which are sites of direct ion exchange with the environment.

A multi-frequency radiometric measurement of soil moisture content over bare and vegetated fields

NASA Technical Reports Server (NTRS)

Wang, J. R.; Schmugge, T. J.; Mcmurtrey, J. E., III; Gould, W. I.; Glazar, W. S.; Fuchs, J. E. (Principal Investigator)

1981-01-01

A USDA Beltsville Agricultural Research Center site was used for an experiment in which soil moisture remote sensing over bare, grass, and alfalfa fields was conducted over a three-month period using 0.6 GHz, 1.4 GHz, and 10.6 GHz Dicke-type microwave radiometers mounted on mobile towers. Ground truth soil moisture content and ambient air and sil temperatures were obtained concurrently with the radiometric measurements. Biomass of the vegetation cover was sampled about once a week. Soil density for each of the three fields was measured several times during the course of the experiment. Results of the radiometric masurements confirm the frequency dependence of moisture sensing sensitivity reduction reported earlier. Observations over the bare, wet field show that the measured brightness temperature is lowest at 5.0 GHz and highest of 0.6 GHz frequency, a result contrary to expectation based on the estimated dielectric permittivity of soil water mixtures and current radiative transfer model in that frequency range.

An ultrahigh-speed color video camera operating at 1,000,000 fps with 288 frame memories

NASA Astrophysics Data System (ADS)

Kitamura, K.; Arai, T.; Yonai, J.; Hayashida, T.; Kurita, T.; Maruyama, H.; Namiki, J.; Yanagi, T.; Yoshida, T.; van Kuijk, H.; Bosiers, Jan T.; Saita, A.; Kanayama, S.; Hatade, K.; Kitagawa, S.; Etoh, T. Goji

2008-11-01

We developed an ultrahigh-speed color video camera that operates at 1,000,000 fps (frames per second) and had capacity to store 288 frame memories. In 2005, we developed an ultrahigh-speed, high-sensitivity portable color camera with a 300,000-pixel single CCD (ISIS-V4: In-situ Storage Image Sensor, Version 4). Its ultrahigh-speed shooting capability of 1,000,000 fps was made possible by directly connecting CCD storages, which record video images, to the photodiodes of individual pixels. The number of consecutive frames was 144. However, longer capture times were demanded when the camera was used during imaging experiments and for some television programs. To increase ultrahigh-speed capture times, we used a beam splitter and two ultrahigh-speed 300,000-pixel CCDs. The beam splitter was placed behind the pick up lens. One CCD was located at each of the two outputs of the beam splitter. The CCD driving unit was developed to separately drive two CCDs, and the recording period of the two CCDs was sequentially switched. This increased the recording capacity to 288 images, an increase of a factor of two over that of conventional ultrahigh-speed camera. A problem with the camera was that the incident light on each CCD was reduced by a factor of two by using the beam splitter. To improve the light sensitivity, we developed a microlens array for use with the ultrahigh-speed CCDs. We simulated the operation of the microlens array in order to optimize its shape and then fabricated it using stamping technology. Using this microlens increased the light sensitivity of the CCDs by an approximate factor of two. By using a beam splitter in conjunction with the microlens array, it was possible to make an ultrahigh-speed color video camera that has 288 frame memories but without decreasing the camera's light sensitivity.

Frequency modulation detection atomic force microscopy in the liquid environment

NASA Astrophysics Data System (ADS)

Jarvis, S. P.; Ishida, T.; Uchihashi, T.; Nakayama, Y.; Tokumoto, H.

True atomic resolution imaging using frequency modulation detection is already well established in ultra-high vacuum. In this paper we demonstrate that it also has great potential in the liquid environment. Using a combination of magnetic activation and high-aspect-ratio carbon nanotube probes, we show that imaging can be readily combined with point spectroscopy, revealing both the tip-sample interaction and the structure of the intermediate liquid.

On the Contribution of Curl-Free Current Patterns to the Ultimate Intrinsic Signal-to-Noise Ratio at Ultra-High Field Strength.

PubMed

Pfrommer, Andreas; Henning, Anke

2017-05-01

The ultimate intrinsic signal-to-noise ratio (SNR) is a coil independent performance measure to compare different receive coil designs. To evaluate this benchmark in a sample, a complete electromagnetic basis set is required. The basis set can be obtained by curl-free and divergence-free surface current distributions, which excite linearly independent solutions to Maxwell's equations. In this work, we quantitatively investigate the contribution of curl-free current patterns to the ultimate intrinsic SNR in a spherical head-sized model at 9.4 T. Therefore, we compare the ultimate intrinsic SNR obtained with having only curl-free or divergence-free current patterns, with the ultimate intrinsic SNR obtained from a combination of curl-free and divergence-free current patterns. The influence of parallel imaging is studied for various acceleration factors. Moreover results for different field strengths (1.5 T up to 11.7 T) are presented at specific voxel positions and acceleration factors. The full-wave electromagnetic problem is analytically solved using dyadic Green's functions. We show, that at ultra-high field strength (B 0 ⩾7T) a combination of curl-free and divergence-free current patterns is required to achieve the best possible SNR at any position in a spherical head-sized model. On 1.5- and 3T platforms, divergence-free current patterns are sufficient to cover more than 90% of the ultimate intrinsic SNR. Copyright © 2017 John Wiley & Sons, Ltd.

Nonlinear response of the immune system to power-frequency magnetic fields.

PubMed

Marino, A A; Wolcott, R M; Chervenak, R; Jourd'Heuil, F; Nilsen, E; Frilot, C

2000-09-01

Studies of the effects of power-frequency electromagnetic fields (EMFs) on the immune and other body systems produced positive and negative results, and this pattern was usually interpreted to indicate the absence of real effects. However, if the biological effects of EMFs were governed by nonlinear laws, deterministic responses to fields could occur that were both real and inconsistent, thereby leading to both types of results. The hypothesis of real inconsistent effects due to EMFs was tested by exposing mice to 1 G, 60 Hz for 1-105 days and observing the effect on 20 immune parameters, using flow cytometry and functional assays. The data were evaluated by means of a novel statistical procedure that avoided averaging away oppositely directed changes in different animals, which we perceived to be the problem in some of the earlier EMF studies. The reliability of the procedure was shown using appropriate controls. In three independent experiments involving exposure for 21 or more days, the field altered lymphoid phenotype even though the changes in individual immune parameters were inconsistent. When the data were evaluated using traditional linear statistical methods, no significant difference in any immune parameter was found. We were able to mimic the results by sampling from known chaotic systems, suggesting that deterministic chaos could explain the effect of fields on the immune system. We conclude that exposure to power-frequency fields produced changes in the immune system that were both real and inconsistent.

Ultra-high field NMR and MRI - the role of magnet technology to increase sensitivity and specificity

NASA Astrophysics Data System (ADS)

Moser, Ewald; Laistler, Elmar; Schmitt, Franz; Kontaxis, Georg

2017-08-01

"History, of course, is difficult to write, if for no other reason, than that it has so many players and so many authors." - P. J. Keating (former Australian Prime Minister) Starting with post-war developments in nuclear magnetic resonance (NMR) a race for stronger and stronger magnetic fields has begun in the 1950s to overcome the inherently low sensitivity of this promising method. Further challenges were larger magnet bores to accommodate small animals and eventually humans. Initially, resistive electromagnets with small pole distances, or sample volumes, and field strengths up to 2.35 T (or 100 MHz 1H frequency) were used in applications in physics, chemistry, and material science. This was followed by stronger and more stable (NbTi based) superconducting magnet technology typically implemented first for small-bore systems in analytical chemistry, biochemistry and structural biology, and eventually allowing larger horizontal-bore magnets with diameters large enough to fit small laboratory animals. By the end of the 1970s, first low-field resistive magnets big enough to accommodate humans were developed and superconducting whole-body systems followed. Currently, cutting-edge analytical NMR systems are available at proton frequencies up to 1 GHz (23.5 T) based on Nb3Sn at 1.9 K. A new 1.2 GHz system (28 T) at 1.9 K, operating in persistent mode but using a combination of low and high temperature multi-filament superconductors is to be released. Preclinical instruments range from small-bore animal systems with typically 600 - 800 MHz (14.1 - 18.8 T) up to 900 MHz (21 T) at 1.9 K. Human whole-body MRI systems currently operate up to 10.5 T. Hybrid combined superconducting and resistive electromagnets with even higher field strength of 45 T dc and 100 T pulsed, are available for material research, of course with smaller free bore diameters. This rather costly development towards higher and higher field strength is a consequence of the inherently low and, thus

Ultra-high density aligned Carbon-nanotube with controled nano-morphology for supercapacitors

NASA Astrophysics Data System (ADS)

Ghaffari, Mehdi; Zhao, Ran; Liu, Yang; Zhou, Yue; Cheng, Jiping; Guzman de Villoria, Roberto; Wardle, B. L.; Zhang, Q. M.

2012-02-01

Recent advances in fabricating controlled-morphology vertically aligned carbon nanotubes (VA-CNTs) with ultrahigh volume fractioncreate unique opportunities for developing unconventional supercapacitors with ultra-high energy density, power density, and long charge/discharge cycle life.Continuous paths through inter-VA-CNT channels allow fast ion transport, and high electrical conduction of the aligned CNTs in the composite electrodes lead to fast discharge speed. We investigate the charge-discharge characteristics of VA-CNTs with >20 vol% of CNT and ionic liquids as electrolytes. By employing both the electric and electromechanical spectroscopes, as well as nanostructured materials characterization, the ion transport and storage behaviors in porous electrodes are studied. The results suggest pathways for optimizing the electrode morphology in supercapacitorsusing ultra-high volume fraction VA-CNTs to further enhance performance.

Interior sound field control using generalized singular value decomposition in the frequency domain.

PubMed

Pasco, Yann; Gauthier, Philippe-Aubert; Berry, Alain; Moreau, Stéphane

2017-01-01

The problem of controlling a sound field inside a region surrounded by acoustic control sources is considered. Inspired by the Kirchhoff-Helmholtz integral, the use of double-layer source arrays allows such a control and avoids the modification of the external sound field by the control sources by the approximation of the sources as monopole and radial dipole transducers. However, the practical implementation of the Kirchhoff-Helmholtz integral in physical space leads to large numbers of control sources and error sensors along with excessive controller complexity in three dimensions. The present study investigates the potential of the Generalized Singular Value Decomposition (GSVD) to reduce the controller complexity and separate the effect of control sources on the interior and exterior sound fields, respectively. A proper truncation of the singular basis provided by the GSVD factorization is shown to lead to effective cancellation of the interior sound field at frequencies below the spatial Nyquist frequency of the control sources array while leaving the exterior sound field almost unchanged. Proofs of concept are provided through simulations achieved for interior problems by simulations in a free field scenario with circular arrays and in a reflective environment with square arrays.

Defect-free ultrahigh flux asymmetric membranes

DOEpatents

Pinnau, Ingo; Koros, William J.

1990-01-01

Defect-free, ultrahigh flux integrally-skinned asymmetric membranes having extremely thin surface layers (<0.2 .mu.m) comprised of glassy polymers are disclosed. The membranes are formed by casting an appropriate drope followed by forced convective evaporation of solvent to obtain a dry phase separated asymmetrical structure. The structure is then washed in a precipitation liquid and dried.

Coupled modes, frequencies and fields of a dielectric resonator and a cavity using coupled mode theory

NASA Astrophysics Data System (ADS)

Elnaggar, Sameh Y.; Tervo, Richard; Mattar, Saba M.

2014-01-01

Probes consisting of a dielectric resonator (DR) inserted in a cavity are important integral components of electron paramagnetic resonance (EPR) spectrometers because of their high signal-to-noise ratio. This article studies the behavior of this system, based on the coupling between its dielectric and cavity modes. Coupled-mode theory (CMT) is used to determine the frequencies and electromagnetic fields of this coupled system. General expressions for the frequencies and field distributions are derived for both the resulting symmetric and anti-symmetric modes. These expressions are applicable to a wide range of frequencies (from MHz to THz). The coupling of cavities and DRs of various sizes and their resonant frequencies are studied in detail. Since the DR is situated within the cavity then the coupling between them is strong. In some cases the coupling coefficient, κ, is found to be as high as 0.4 even though the frequency difference between the uncoupled modes is large. This is directly attributed to the strong overlap between the fields of the uncoupled DR and cavity modes. In most cases, this improves the signal to noise ratio of the spectrometer. When the DR and the cavity have the same frequency, the coupled electromagnetic fields are found to contain equal contributions from the fields of the two uncoupled modes. This situation is ideal for the excitation of the probe through an iris on the cavity wall. To verify and validate the results, finite element simulations are carried out. This is achieved by simulating the coupling between a cylindrical cavity's TE011 and the dielectric insert's TE01δ modes. Coupling between the modes of higher order is also investigated and discussed. Based on CMT, closed form expressions for the fields of the coupled system are proposed. These expressions are crucial in the analysis of the probe's performance.

Ultra-High Temperature Materials Characterization for Propulsion Applications

NASA Technical Reports Server (NTRS)

Rogers, Jan; Hyers, Robert

2007-01-01

Propulsion system efficiency increases as operating temperatures are increased. Some very high-temperature materials are being developed, including refractory metal alloys, carbides, borides, and silicides. System design requires data for materials properties at operating temperatures. Materials property data are not available for many materials of interest at the desired operating temperatures (up to approx. 3000 K). The objective of this work is to provide important physical property data at ultra-high temperatures. The MSFC Electrostatic levitation (ESL) facility can provide measurements of thermophysical properties which include: creep strength, density and thermal expansion for materials being developed for propulsion applications. The ESL facility uses electrostatic fields to position samples between electrodes during processing and characterization studies. Because the samples float between the electrodes during studies, they are free from any contact with a container or test apparatus. This provides a high purity environment for the study of high-temperature, reactive materials. ESL can be used to process a wide variety of materials including metals, alloys, ceramics, glasses and semiconductors. The MSFC ESL has provided non-contact measurements of properties of materials up to 3400 C. Density and thermal expansion are measured by analyzing digital images of the sample at different temperatures. Our novel, non-contact method for measuring creep uses rapid rotation to deform the sample. Digital images of the deformed samples are analyzed to obtain the creep properties, which match those obtained using ASTM Standard E-139 for Nb at 1985 C. Data from selected ESL-based characterization studies will be presented. The ESL technique could support numerous propulsion technologies by advancing the knowledge base and the technology readiness level for ultra-high temperature materials. Applications include non-eroding nozzle materials and lightweight, high

A Power-Frequency Electric Field Sensor for Portable Measurement

PubMed Central

Xiao, Dongping; Ma, Qichao; Xie, Yutong; Zheng, Qi

2018-01-01

In this paper, a new type of electric field sensor is proposed for the health and safety protection of inspection staff in high-voltage environments. Compared with the traditional power frequency electric field measurement instruments, the portable instrument has some special performance requirements and, thus, a new kind of double spherical shell sensor is presented. First, the mathematical relationships between the induced voltage of the sensor, the output voltage of the measurement circuit, and the original electric field in free space are deduced theoretically. These equations show the principle of the proposed sensor to measure the electric field and the effect factors of the measurement. Next, the characteristics of the sensor are analyzed through simulation. The simulation results are in good agreement with the theoretical analysis. The influencing rules of the size and material of the sensor on the measurement results are summarized. Then, the proposed sensor and the matching measurement system are used in a physical experiment. After calibration, the error of the measurement system is discussed. Lastly, the directional characteristic of the proposed sensor is experimentally tested. PMID:29614753

A Power-Frequency Electric Field Sensor for Portable Measurement.

PubMed

Xiao, Dongping; Ma, Qichao; Xie, Yutong; Zheng, Qi; Zhang, Zhanlong

2018-03-31

In this paper, a new type of electric field sensor is proposed for the health and safety protection of inspection staff in high-voltage environments. Compared with the traditional power frequency electric field measurement instruments, the portable instrument has some special performance requirements and, thus, a new kind of double spherical shell sensor is presented. First, the mathematical relationships between the induced voltage of the sensor, the output voltage of the measurement circuit, and the original electric field in free space are deduced theoretically. These equations show the principle of the proposed sensor to measure the electric field and the effect factors of the measurement. Next, the characteristics of the sensor are analyzed through simulation. The simulation results are in good agreement with the theoretical analysis. The influencing rules of the size and material of the sensor on the measurement results are summarized. Then, the proposed sensor and the matching measurement system are used in a physical experiment. After calibration, the error of the measurement system is discussed. Lastly, the directional characteristic of the proposed sensor is experimentally tested.

A multi-frequency radiometric measurement of soil moisture content over bare and vegetated fields

NASA Technical Reports Server (NTRS)

Wang, J. R.; Schmugge, T. J.; Gould, W. I.; Glazar, W. S.; Fuchs, J. E.; Mcmurtrey, J. E., III

1982-01-01

An experiment on soil moisture remote sensing was conducted during July to September 1981 on bare, grass, and alfalfa fields at frequencies of 0.6, 1.4, 5.0, and 10.6 GHz with radiometers mounted on mobile towers. The results confirm the frequency dependence of sensitivity reduction due to the presence of vegetation cover. For the type of vegetated fields reported here, the vegetation effect is appreciable even at 0.6 GHz. Measurements over bare soil show that when the soil is wet, the measured brightness temperature is lowest at 5.0 GHz and highest at 0.6 GHz, a result contrary to the expectation based on the estimated dielectric permittivity of soil-water mixtures and the current radiative transfer model in that frequency range.

Ultra-high Temperature Emittance Measurements for Space and Missile Applications

NASA Technical Reports Server (NTRS)

Rogers, Jan; Crandall, David

2009-01-01

Advanced modeling and design efforts for many aerospace components require high temperature emittance data. Applications requiring emittance data include propulsion systems, radiators, aeroshells, heatshields/thermal protection systems, and leading edge surfaces. The objective of this work is to provide emittance data at ultra-high temperatures. MSFC has a new instrument for the measurement of emittance at ultra-high temperatures, the Ultra-High Temperature Emissometer System (Ultra-HITEMS). AZ Technology Inc. developed the instrument, designed to provide emittance measurements over the temperature range 700-3500K. The Ultra-HITEMS instrument measures the emittance of samples, heated by lasers, in vacuum, using a blackbody source and a Fourier Transform Spectrometer. Detectors in a Nicolet 6700 FT-IR spectrometer measure emittance over the spectral range of 0.4-25 microns. Emitted energy from the specimen and output from a Mikron M390S blackbody source at the same temperature with matched collection geometry are measured. Integrating emittance over the spectral range yields the total emittance. The ratio provides a direct measure of total hemispherical emittance. Samples are heated using lasers. Optical pyrometry provides temperature data. Optical filters prevent interference from the heating lasers. Data for Inconel 718 show excellent agreement with results from literature and ASTM 835. Measurements taken from levitated spherical specimens provide total hemispherical emittance data; measurements taken from flat specimens mounted in the chamber provide near-normal emittance data. Data from selected characterization studies will be presented. The Ultra-HITEMS technique could advance space and missile technologies by advancing the knowledge base and the technology readiness level for ultra-high temperature materials.

Herpin effective media resonant underlayers and resonant overlayer designs for ultra-high NA interference lithography.

PubMed

Bourke, Levi; Blaikie, Richard J

2017-12-01

Dielectric waveguide resonant underlayers are employed in ultra-high NA interference photolithography to effectively double the depth of field. Generally a single high refractive index waveguiding layer is employed. Here multilayer Herpin effective medium methods are explored to develop equivalent multilayer waveguiding layers. Herpin equivalent resonant underlayers are shown to be suitable replacements provided at least one layer within the Herpin trilayer supports propagating fields. In addition, a method of increasing the intensity incident upon the photoresist using resonant overlayers is also developed. This method is shown to greatly enhance the intensity within the photoresist making the use of thicker, safer, non-absorbing, low refractive index matching liquids potentially suitable for large-scale applications.

Wireless actuation of piezoelectric coupled micromembrane using radio frequency magnetic field for biomedical applications

NASA Astrophysics Data System (ADS)

Sinha, Dhiraj

2017-04-01

We report on a novel technique of wireless actuation of a micromembrane mounted on a piezoelectric stack using radio frequency magnetic fields. The magnetic field component of the radio frequency field induces time varying voltage across the leads of the piezoelectric stack which results in vibrations of the piezoelectric stack which are eventually transferred to a micromembrane of silicon nitride mounted on top of it. Thus, wireless actuation of micromembranes is achieved which is measured using a laser-photodetector system. Wireless actuation of micromembranes has applications in controlled drug delivery with rates of the order of tens of nanolitres per second. It can also be used in controlling capsule endoscopes, in vivo sensors, and micromachines for biomedical applications.

High-frequency noise characterization of graphene field effect transistors on SiC substrates

NASA Astrophysics Data System (ADS)

Yu, C.; He, Z. Z.; Song, X. B.; Liu, Q. B.; Dun, S. B.; Han, T. T.; Wang, J. J.; Zhou, C. J.; Guo, J. C.; Lv, Y. J.; Cai, S. J.; Feng, Z. H.

2017-07-01

Considering its high carrier mobility and high saturation velocity, a low-noise amplifier is thought of as being the most attractive analogue application of graphene field-effect transistors. The noise performance of graphene field-effect transistors at frequencies in the K-band remains unknown. In this work, the noise parameters of a graphene transistor are measured from 10 to 26 GHz and noise models are built with the data. The extrinsic minimum noise figure for a graphene transistor reached 1.5 dB, and the intrinsic minimum noise figure was as low as 0.8 dB at a frequency of 10 GHz, which were comparable with the results from tests on Si CMOS and started to approach those for GaAs and InP transistors. Considering the short development time, the current results are a significant step forward for graphene transistors and show their application potential in high-frequency electronics.

Method for imaging with low frequency electromagnetic fields

DOEpatents

Lee, Ki H.; Xie, Gan Q.

1994-01-01

A method for imaging with low frequency electromagnetic fields, and for interpreting the electromagnetic data using ray tomography, in order to determine the earth conductivity with high accuracy and resolution. The imaging method includes the steps of placing one or more transmitters, at various positions in a plurality of transmitter holes, and placing a plurality of receivers in a plurality of receiver holes. The transmitters generate electromagnetic signals which diffuse through a medium, such as earth, toward the receivers. The measured diffusion field data H is then transformed into wavefield data U. The traveltimes corresponding to the wavefield data U, are then obtained, by charting the wavefield data U, using a different regularization parameter .alpha. for each transform. The desired property of the medium, such as conductivity, is then derived from the velocity, which in turn is constructed from the wavefield data U using ray tomography.

Method for imaging with low frequency electromagnetic fields

DOEpatents

Lee, K.H.; Xie, G.Q.

1994-12-13

A method is described for imaging with low frequency electromagnetic fields, and for interpreting the electromagnetic data using ray tomography, in order to determine the earth conductivity with high accuracy and resolution. The imaging method includes the steps of placing one or more transmitters, at various positions in a plurality of transmitter holes, and placing a plurality of receivers in a plurality of receiver holes. The transmitters generate electromagnetic signals which diffuse through a medium, such as earth, toward the receivers. The measured diffusion field data H is then transformed into wavefield data U. The travel times corresponding to the wavefield data U, are then obtained, by charting the wavefield data U, using a different regularization parameter [alpha] for each transform. The desired property of the medium, such as conductivity, is then derived from the velocity, which in turn is constructed from the wavefield data U using ray tomography. 13 figures.

Search for Ultra-High Energy Photons with the Pierre Auger Observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Homola, Piotr

One of key scientific objectives of the Pierre Auger Observatory is the search for ultra-high energy photons. Such photons could originate either in the interactions of energetic cosmic-ray nuclei with the cosmic microwave background (so-called cosmogenic photons) or in the exotic scenarios, e.g. those assuming a production and decay of some hypothetical super-massive particles. The latter category of models would imply relatively large fluxes of photons with ultra-high energies at Earth, while the former, involving interactions of cosmic-ray nuclei with the microwave background - just the contrary: very small fractions. The investigations on the data collected so far in themore » Pierre Auger Observatory led to placing very stringent limits to ultra-high energy photon fluxes: below the predictions of the most of the exotic models and nearing the predicted fluxes of the cosmogenic photons. In this paper the status of these investigations and perspectives for further studies are summarized.« less

A Spatial-frequency Method for Analyzing Antenna-to-Probe Interactions in Near-field Antenna Measurements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brock, Billy C.

The measurement of the radiation characteristics of an antenna on a near-field range requires that the antenna under test be located very close to the near-field probe. Although the direct coupling is utilized for characterizing the near field, this close proximity also presents the opportunity for significant undesired interactions (for example, reflections) to occur between the antenna and the near-field probe. When uncompensated, these additional interactions will introduce error into the measurement, increasing the uncertainty in the final gain pattern obtained through the near-field-to-far-field transformation. Quantifying this gain-uncertainty contribution requires quantifying the various additional interactions. A method incorporating spatial-frequency analysismore » is described which allows the dominant interaction contributions to be easily identified and quantified. In addition to identifying the additional antenna-to-probe interactions, the method also allows identification and quantification of interactions with other nearby objects within the measurement room. Because the method is a spatial-frequency method, wide-bandwidth data is not required, and it can be applied even when data is available at only a single temporal frequency. This feature ensures that the method can be applied to narrow-band antennas, where a similar time-domain analysis would not be possible. - 3 - - 4 -« less

NOTE Effects of skeletal muscle anisotropy on induced currents from low-frequency magnetic fields

NASA Astrophysics Data System (ADS)

Tachas, Nikolaos J.; Samaras, Theodoros; Baskourelos, Konstantinos; Sahalos, John N.

2009-12-01

Studies which take into account the anisotropy of tissue dielectric properties for the numerical assessment of induced currents from low-frequency magnetic fields are scarce. In the present study, we compare the induced currents in two anatomical models, using the impedance method. In the first model, we assume that all tissues have isotropic conductivity, whereas in the second one, we assume anisotropic conductivity for the skeletal muscle. Results show that tissue anisotropy should be taken into account when investigating the exposure to low-frequency magnetic fields, because it leads to higher induced current values.

Radio frequency magnetic field effects on molecular dynamics and iron uptake in cage proteins.

PubMed

Céspedes, Oscar; Inomoto, Osamu; Kai, Shoichi; Nibu, Yoshinori; Yamaguchi, Toshio; Sakamoto, Nobuyoshi; Akune, Tadahiro; Inoue, Masayoshi; Kiss, Takanobu; Ueno, Shoogo

2010-05-01

The protein ferritin has a natural ferrihydrite nanoparticle that is superparamagnetic at room temperature. For native horse spleen ferritin, we measure the low field magnetic susceptibility of the nanoparticle as 2.2 x 10(-6) m(3) kg(-1) and its Néel relaxation time at about 10(-10) s. Superparamagnetic nanoparticles increase their internal energy when exposed to radio frequency magnetic fields due to the lag between magnetization and applied field. The energy is dissipated to the surrounding peptidic cage, altering the molecular dynamics and functioning of the protein. This leads to an increased population of low energy vibrational states under a magnetic field of 30 microT at 1 MHz, as measured via Raman spectroscopy. After 2 h of exposure, the proteins have a reduced iron intake rate of about 20%. Our results open a new path for the study of non-thermal bioeffects of radio frequency magnetic fields at the molecular scale.

Visible-to-visible four-photon ultrahigh resolution microscopic imaging with 730-nm diode laser excited nanocrystals.

PubMed

Wang, Baoju; Zhan, Qiuqiang; Zhao, Yuxiang; Wu, Ruitao; Liu, Jing; He, Sailing

2016-01-25

Further development of multiphoton microscopic imaging is confronted with a number of limitations, including high-cost, high complexity and relatively low spatial resolution due to the long excitation wavelength. To overcome these problems, for the first time, we propose visible-to-visible four-photon ultrahigh resolution microscopic imaging by using a common cost-effective 730-nm laser diode to excite the prepared Nd(3+)-sensitized upconversion nanoparticles (Nd(3+)-UCNPs). An ordinary multiphoton scanning microscope system was built using a visible CW diode laser and the lateral imaging resolution as high as 161-nm was achieved via the four-photon upconversion process. The demonstrated large saturation excitation power for Nd(3+)-UCNPs would be more practical and facilitate the four-photon imaging in the application. A sample with fine structure was imaged to demonstrate the advantages of visible-to-visible four-photon ultrahigh resolution microscopic imaging with 730-nm diode laser excited nanocrystals. Combining the uniqueness of UCNPs, the proposed visible-to-visible four-photon imaging would be highly promising and attractive in the field of multiphoton imaging.

Adaptive frequency-difference matched field processing for high frequency source localization in a noisy shallow ocean.

PubMed

Worthmann, Brian M; Song, H C; Dowling, David R

2017-01-01

Remote source localization in the shallow ocean at frequencies significantly above 1 kHz is virtually impossible for conventional array signal processing techniques due to environmental mismatch. A recently proposed technique called frequency-difference matched field processing (Δf-MFP) [Worthmann, Song, and Dowling (2015). J. Acoust. Soc. Am. 138(6), 3549-3562] overcomes imperfect environmental knowledge by shifting the signal processing to frequencies below the signal's band through the use of a quadratic product of frequency-domain signal amplitudes called the autoproduct. This paper extends these prior Δf-MFP results to various adaptive MFP processors found in the literature, with particular emphasis on minimum variance distortionless response, multiple constraint method, multiple signal classification, and matched mode processing at signal-to-noise ratios (SNRs) from -20 to +20 dB. Using measurements from the 2011 Kauai Acoustic Communications Multiple University Research Initiative experiment, the localization performance of these techniques is analyzed and compared to Bartlett Δf-MFP. The results show that a source broadcasting a frequency sweep from 11.2 to 26.2 kHz through a 106 -m-deep sound channel over a distance of 3 km and recorded on a 16 element sparse vertical array can be localized using Δf-MFP techniques within average range and depth errors of 200 and 10 m, respectively, at SNRs down to 0 dB.

Study on creep of fiber reinforced ultra-high strength concrete based on strength

NASA Astrophysics Data System (ADS)

Peng, Wenjun; Wang, Tao

2018-04-01

To complement the creep performance of ultra-high strength concrete, the long creep process of fiber reinforced concrete was studied in this paper. The long-term creep process and regularity of ultra-high strength concrete with 0.5% PVA fiber under the same axial compression were analyzed by using concrete strength (C80/C100/C120) as a variable. The results show that the creep coefficient of ultra-high strength concrete decreases with the increase of concrete strength. Compared with ACI209R (92), GL2000 models, it is found that the predicted value of ACI209R (92) are close to the experimental value, and the creep prediction model suitable for this experiment is proposed based on ACI209R (92).

Low frequency electric field variations during HF transmissions on a mother-daughter rocket

NASA Technical Reports Server (NTRS)

Rosenberg, T. J.; Maynard, M. C.; Holtet, J. A.; Karlsen, N. O.; Egeland, A.; Moe, T. E.; Troim, J.

1977-01-01

HF wave propagation experiments were conducted on Mother-Daughter rockets in the polar ionosphere. Swept frequency transmissions from the Mother, nominally covering the range from 0.5 to 5 MHz in both CW and pulse modes, are received by the Daughter. In the most recent rocket of the series, the Mother also contained an AC electric field spectrometer covering the frequency range from 10 Hz to 100 kHz in four decade bands. The low frequency response of the ionosphere with respect to waves emitted from the onboard HF transmitter is examined.

Recent advances in capillary ultrahigh pressure liquid chromatography.

PubMed

Blue, Laura E; Franklin, Edward G; Godinho, Justin M; Grinias, James P; Grinias, Kaitlin M; Lunn, Daniel B; Moore, Stephanie M

2017-11-10

In the twenty years since its initial demonstration, capillary ultrahigh pressure liquid chromatography (UHPLC) has proven to be one of most powerful separation techniques for the analysis of complex mixtures. This review focuses on the most recent advances made since 2010 towards increasing the performance of such separations. Improvements in capillary column preparation techniques that have led to columns with unprecedented performance are described. New stationary phases and phase supports that have been reported over the past decade are detailed, with a focus on their use in capillary formats. A discussion on the instrument developments that have been required to ensure that extra-column effects do not diminish the intrinsic efficiency of these columns during analysis is also included. Finally, the impact of these capillary UHPLC topics on the field of proteomics and ways in which capillary UHPLC may continue to be applied to the separation of complex samples are addressed. Copyright © 2017 Elsevier B.V. All rights reserved.

Tunable terahertz wave-plate based on dual-frequency liquid crystal controlled by alternating electric field.

PubMed

Yu, Jian-Ping; Chen, Sai; Fan, Fei; Cheng, Jie-Rong; Xu, Shi-Tong; Wang, Xiang-Hui; Chang, Sheng-Jiang

2018-01-22

In this work, the optically anisotropic property of dual-frequency liquid crystals (DFLC) in terahertz (THz) regime has been experimentally investigated, which indicates that the refractive index and birefringence of DFLC can be continuously modulated by both the alternating frequency and intensity of the alternating electric field. This tunability originates from the rotation of DFLC molecules induced by alternating electric fields. The results show that by modulating the alternating frequency from 1 kHz to 100 kHz under 30 kV/m electric field, the 600 μm thickness DFLC cell can play as a tunable quarter-wave plate above 0.68 THz, or a half-wave plate above 1.33 THz. Besides, it can be viewed as a tunable THz phase shifter from 0 to π. Therefore, due to its novel tuning mechanism, DFLC will be of great significance in dynamic manipulating on THz phase and polarization.

The use of ultra-high pressure liquid chromatography with tandem mass spectrometric detection of analysis of agrochemical residues and mycotoxines in food - challenges and applications

USDA-ARS?s Scientific Manuscript database

In the field of food contaminant analysis, the most significant development of recent years has been the integration of ultra-high pressure liquid chromatography (UHPLC), coupled to tandem quadrupole mass spectrometry (MS/MS), into analytical applications. In this review, we describe the emergence o...

A minimally invasive blood-extraction system: elastic self-recovery actuator integrated with an ultrahigh- aspect-ratio microneedle.

PubMed

Li, Cheng Guo; Lee, Kwang; Lee, Chang Yeol; Dangol, Manita; Jung, Hyungil

2012-08-28

A minimally invasive blood-extraction system is fabricated by the integration of an elastic self-recovery actuator and an ultrahigh-aspect-ratio microneedle. The simple elastic self-recovery actuator converts finger force to elastic energy to provide power for blood extraction and transport without requiring an external source of power. This device has potential utility in the biomedical field within the framework of complete micro-electromechanical systems. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Behavioral in-effectiveness of high frequency electromagnetic field in mice.

PubMed

Salunke, Balwant P; Umathe, Sudhir N; Chavan, Jagatpalsingh G

2015-03-01

The present investigation was carried out with an objective to study the influence of high frequency electromagnetic field (HF-EMF) on anxiety, obsessive compulsive disorder (OCD) and depression-like behavior. For exposure to HF-EMF, non-magnetic material was used to fabricate the housing. Mice were exposed to HF-EMF (2.45GHz), 60min/day for 7 or 30 or 60 or 90 or 120days. The exposure was carried out by switching-on inbuilt class-I BLUETOOTH device that operates on 2.45GHz frequency in file transfer mode at a peak density of 100mW. Mice were subjected to the assessment of anxiety, OCD and depression-like behavior for 7 or 30 or 60 or 90 or 120days of exposure. The anxiety-like behavior was assessed by elevated plus maze, open field test and social interaction test. OCD-like behavior was assessed by marble burying behavior, whereas depression-like behavior was assessed by forced swim test and tail suspension test. The present experiment demonstrates that up to 120days of exposure to HF-EMF does not produce anxiety, OCD and depression-like behavior in mice. Copyright © 2014 Elsevier Inc. All rights reserved.

Generation of zonal magnetic fields by low-frequency dispersive electromagnetic waves in a nonuniform dusty magnetoplasma.

PubMed

Shukla, P K

2004-04-01

It is shown that zonal magnetic fields can be parametrically excited by low-frequency dispersive driftlike compressional electromagnetic (DDCEM) modes in a nonuniform dusty magnetoplasma. For this purpose, we derive a pair of coupled equations which exhibits the nonlinear coupling between DDCEM modes and zonal magnetic fields. The coupled mode equations are Fourier analyzed to derive a nonlinear dispersion relation. The latter depicts that zonal magnetic fields are nonlinearly generated at the expense of the low-frequency DDCEM wave energy. The relevance of our investigation to the transfer of energy from short scale DDCEM waves to long scale zonal magnetic field structures in dark molecular clouds is discussed.

Femtosecond pulse with THz repetition frequency based on the coupling between quantum emitters and a plasmonic resonator

NASA Astrophysics Data System (ADS)

Li, Shilei; Ding, Yinxing; Jiao, Rongzhen; Duan, Gaoyan; Yu, Li

2018-03-01

Nanoscale pulsed light is highly desirable in nano-integrated optics. In this paper, we obtained femtosecond pulses with THz repetition frequency via the coupling between quantum emitters (QEs) and plasmonic resonators. Our structure consists of a V -groove (VG) plasmonic resonator and a nanowire embedded with two-level QEs. The influences of the incident light intensity and QE number density on the transmission response for this hybrid system are investigated through semiclassical theory and simulation. The results show that the transmission response can be modulated to the pulse form. And the repetition frequency and extinction ratio of the pulses can be controlled by the incident light intensity and QE number density. The reason is that the coupling causes the output power of nanowire to behave as an oscillating form, the oscillating output power in turn causes the field amplitude in the resonator to oscillate over time. A feedback system is formed between the plasmonic resonator and the QEs in the nanowire. This provides a method for generating narrow pulsed lasers with ultrahigh repetition frequencies in plasmonic systems using a continuous wave input, which has potential applications in generating optical clock signals at the nanoscale.

High harmonic emission from a superposition of multiple unrelated frequency fields.

PubMed

Siegel, T; Torres, R; Hoffmann, D J; Brugnera, L; Procino, I; Zaïr, A; Underwood, Jonathan G; Springate, E; Turcu, I C E; Chipperfield, L E; Marangos, J P

2010-03-29

We report observations and analysis of high harmonic generation driven by a superposition of fields at 1290 nm and 780 nm. These fields are not commensurate in frequency and the superposition leads to an increase in the yield of the mid-plateau harmonics of more than two orders of magnitude compared to using the 1290 nm field alone. Significant extension of the cut-off photon energy is seen even by adding only a small amount of the 780 nm field. These observations are explained by calculations performed in the strong field approximation. Most importantly we find that enhancement is found to arise as a consequence of both increased ionization in the sum-field and modification of the electron trajectories leading to an earlier return time. The enhanced yield even when using modest intensity fields of 5 x 10(13) Wcm(-2) is extended to the 80 eV range and is a promising route to provide a greater photon number for applications in XUV imaging and time-resolved experiments at a high repetition rate.

AMANDA Observations Constrain the Ultrahigh Energy Neutrino Flux

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halzen, Francis; /Wisconsin U., Madison; Hooper, Dan

2006-05-01

A number of experimental techniques are currently being deployed in an effort to make the first detection of ultra-high energy cosmic neutrinos. To accomplish this goal, techniques using radio and acoustic detectors are being developed, which are optimally designed for studying neutrinos with energies in the PeV-EeV range and above. Data from the AMANDA experiment, in contrast, has been used to place limits on the cosmic neutrino flux at less extreme energies (up to {approx}10 PeV). In this letter, we show that by adopting a different analysis strategy, optimized for much higher energy neutrinos, the same AMANDA data can bemore » used to place a limit competitive with radio techniques at EeV energies. We also discuss the sensitivity of the IceCube experiment, in various stages of deployment, to ultra-high energy neutrinos.« less

MEASUREMENT OF SMALL MECHANICAL VIBRATIONS OF BRAIN TISSUE EXPOSED TO EXTREMELY-LOW-FREQUENCY ELECTRIC FIELDS

EPA Science Inventory

Electromagnetic fields can interact with biological tissue both electrically and mechanically. This study investigated the mechanical interaction between brain tissue and an extremely-low-frequency (ELF) electric field by measuring the resultant vibrational amplitude. The exposur...

Spin Biochemistry Modulates Reactive Oxygen Species (ROS) Production by Radio Frequency Magnetic Fields

PubMed Central

Usselman, Robert J.; Hill, Iain; Singel, David J.; Martino, Carlos F.

2014-01-01

The effects of weak magnetic fields on the biological production of reactive oxygen species (ROS) from intracellular superoxide (O2 •−) and extracellular hydrogen peroxide (H2O2) were investigated in vitro with rat pulmonary arterial smooth muscle cells (rPASMC). A decrease in O2 •− and an increase in H2O2 concentrations were observed in the presence of a 7 MHz radio frequency (RF) at 10 μTRMS and static 45 μT magnetic fields. We propose that O2 •− and H2O2 production in some metabolic processes occur through singlet-triplet modulation of semiquinone flavin (FADH•) enzymes and O2 •− spin-correlated radical pairs. Spin-radical pair products are modulated by the 7 MHz RF magnetic fields that presumably decouple flavin hyperfine interactions during spin coherence. RF flavin hyperfine decoupling results in an increase of H2O2 singlet state products, which creates cellular oxidative stress and acts as a secondary messenger that affects cellular proliferation. This study demonstrates the interplay between O2 •− and H2O2 production when influenced by RF magnetic fields and underscores the subtle effects of low-frequency magnetic fields on oxidative metabolism, ROS signaling, and cellular growth. PMID:24681944

Space Flyable Hg(sup +) Frequency Standards

NASA Technical Reports Server (NTRS)

Prestage, John D.; Maleki, Lute

1994-01-01

We discuss a design for a space based atomic frequency standard (AFS) based on Hg(sup +) ions confined in a linear ion trap. This newly developed AFS should be well suited for space borne applications because it can supply the ultra-high stability of a H-maser but its total mass is comparable to that of a NAVSTAR/GPS cesium clock, i.e., about 11kg. This paper will compare the proposed Hg(sup +) AFS to the present day GPS cesium standards to arrive at the 11 kg mass estimate. The proposed space borne Hg(sup +) standard is based upon the recently developed extended linear ion trap architecture which has reduced the size of existing trapped Hg(sup +) standards to a physics package which is comparable in size to a cesium beam tube. The demonstrated frequency stability to below 10(sup -15) of existing Hg(sup +) standards should be maintained or even improved upon in this new architecture. This clock would deliver far more frequency stability per kilogram than any current day space qualified standard.

Ultrahigh-energy cosmic rays from tidally-ignited white dwarfs

NASA Astrophysics Data System (ADS)

Alves Batista, Rafael; Silk, Joseph

2017-11-01

Ultrahigh-energy cosmic rays (UHECRs) can be accelerated by tidal disruption events of stars by black holes. We suggest a novel mechanism for UHECR acceleration wherein white dwarfs (WDs) are tidally compressed by intermediate-mass black holes (IMBHs), leading to their ignition and subsequent explosion as a supernova. Cosmic rays accelerated by the supernova may receive an energy boost when crossing the accretion-powered jet. The rate of encounters between WDs and IMBHs can be relatively high, as the number of IMBHs may be substantially augmented once account is taken of their likely presence in dwarf galaxies. Here we show that this kind of tidal disruption event naturally provides an intermediate composition for the observed UHECRs, and suggest that dwarf galaxies and globular clusters are suitable sites for particle acceleration to ultrahigh energies.

Dynamical mean field theory equations on nearly real frequency axis

NASA Astrophysics Data System (ADS)

Fathi, M. B.; Jafari, S. A.

2010-03-01

The iterated perturbation theory (IPT) equations of the dynamical mean field theory (DMFT) for the half-filled Hubbard model are solved on nearly real frequencies at various values of the Hubbard parameters, U, to investigate the nature of metal-insulator transition (MIT) at finite temperatures. This method avoids the instabilities associated with the infamous Padé analytic continuation and reveals fine structures across the MIT at finite temperatures, which cannot be captured by conventional methods for solving DMFT-IPT equations on Matsubara frequencies. Our method suggests that at finite temperatures, there is a crossover from a bad metal to a bad insulator in which the height of the quasi-particle (Kondo) peak decreases to a non-zero small bump, which gradually suppresses as one moves deeper into the bad insulating regime.

Radio frequency magnetic field limits of Nb and Nb 3Sn

DOE PAGES

Posen, S.; Valles, N.; Liepe, M.

2015-07-21

Superconducting radio frequency (srf) cavities, essential components of many large particle accelerators, rely on the metastable flux-free state of superconducting materials. In this Letter, we present results of experiments measuring the magnetic field limits of two srf materials, Nb and Nb 3Sn. Resonators made using these materials were probed using both high power rf pulses and dc magnetic fields. Nb, which is the current standard material for srf cavities in applications, was found to be limited by the superheating field H sh when prepared using methods to avoid excessive rf dissipation at high fields. Nb 3Sn, which is a promisingmore » alternative material that is still in the early stages of development for srf purposes, was found to be limited between the onset field of metastability H c1 and H sh. Furthermore, analysis of the results shows that the limitation is consistent with nucleation of flux penetration at defects in the rf layer.« less

Radio frequency electromagnetic field compliance assessment of multi-band and MIMO equipped radio base stations.

PubMed

Thors, Björn; Thielens, Arno; Fridén, Jonas; Colombi, Davide; Törnevik, Christer; Vermeeren, Günter; Martens, Luc; Joseph, Wout

2014-05-01

In this paper, different methods for practical numerical radio frequency exposure compliance assessments of radio base station products were investigated. Both multi-band base station antennas and antennas designed for multiple input multiple output (MIMO) transmission schemes were considered. For the multi-band case, various standardized assessment methods were evaluated in terms of resulting compliance distance with respect to the reference levels and basic restrictions of the International Commission on Non-Ionizing Radiation Protection. Both single frequency and multiple frequency (cumulative) compliance distances were determined using numerical simulations for a mobile communication base station antenna transmitting in four frequency bands between 800 and 2600 MHz. The assessments were conducted in terms of root-mean-squared electromagnetic fields, whole-body averaged specific absorption rate (SAR) and peak 10 g averaged SAR. In general, assessments based on peak field strengths were found to be less computationally intensive, but lead to larger compliance distances than spatial averaging of electromagnetic fields used in combination with localized SAR assessments. For adult exposure, the results indicated that even shorter compliance distances were obtained by using assessments based on localized and whole-body SAR. Numerical simulations, using base station products employing MIMO transmission schemes, were performed as well and were in agreement with reference measurements. The applicability of various field combination methods for correlated exposure was investigated, and best estimate methods were proposed. Our results showed that field combining methods generally considered as conservative could be used to efficiently assess compliance boundary dimensions of single- and dual-polarized multicolumn base station antennas with only minor increases in compliance distances. © 2014 Wiley Periodicals, Inc.

BAKABLE ULTRA-HIGH VACUUM VALVE

DOEpatents

Mark, J.T.; Gantz, I.H.

1962-07-10

S>This patent relates to a valve useful in applications involving successively closing and opening a communication between a chamber evacuated to an ultra-high vacuum condition of the order of 10/sup -10/ millimeters of mercury and another chamber or the ambient. The valve is capable of withstanding extended baking at 450 deg C and repeated opening and closing without repiacement of the valve seat (approximately 200 cycle limit). The seal is formed by mutual interdiffusion weld, coerced by a pneumatic actuator. (AEC)

Application of ultra-high performance concrete to bridge girders.

DOT National Transportation Integrated Search

2009-02-01

"Ultra-High Performance Concrete (UHPC) is a new class of concrete that has superior performance characteristics : compared to conventional concrete. The enhanced strength and durability properties of UHPC are mainly due to optimized : particle grada...

Remote enzyme activation using gold coated magnetite as antennae for radio frequency fields

NASA Astrophysics Data System (ADS)

Collins, Christian B.; Ackerson, Christopher J.

2018-02-01

The emerging field of remote enzyme activation, or the ability to remotely turn thermophilic increase enzyme activity, could be a valuable tool for understanding cellular processes. Through exploitation of the temperature dependence of enzymatic processes and high thermal stability of thermophilic enzymes these experiments utilize nanoparticles as `antennae' that convert radiofrequency (RF) radiation into local heat, increasing activity of the enzymes without increasing the temperature of the surrounding bulk solution. To investigate this possible tool, thermolysin, a metalloprotease was covalently conjugated to 4nm gold coated magnetite particles via peptide bond formation with the protecting ligand shell. RF stimulated protease activity at 17.76 MHz in a solenoid shaped antenna, utilizing both electric and magnetic field interactions was investigated. On average 40 percent higher protease activity was observed in the radio frequency fields then when bulk heating the sample to the same temperature. This is attributed to electrophoretic motion of the nanoparticle enzyme conjugates and local regions of heat generated by the relaxation of the magnetite cores with the oscillating field. Radio frequency local heating of nanoparticles conjugated to enzymes as demonstrated could be useful in the activation of specific enzymes in complex cellular environments.

Response of Cultured Neuronal Network Activity After High-Intensity Power Frequency Magnetic Field Exposure

PubMed Central

Saito, Atsushi; Takahashi, Masayuki; Makino, Kei; Suzuki, Yukihisa; Jimbo, Yasuhiko; Nakasono, Satoshi

2018-01-01

High-intensity and low frequency (1–100 kHz) time-varying electromagnetic fields stimulate the human body through excitation of the nervous system. In power frequency range (50/60 Hz), a frequency-dependent threshold of the external electric field-induced neuronal modulation in cultured neuronal networks was used as one of the biological indicator in international guidelines; however, the threshold of the magnetic field-induced neuronal modulation has not been elucidated. In this study, we exposed rat brain-derived neuronal networks to a high-intensity power frequency magnetic field (hPF-MF), and evaluated the modulation of synchronized bursting activity using a multi-electrode array (MEA)-based extracellular recording technique. As a result of short-term hPF-MF exposure (50–400 mT root-mean-square (rms), 50 Hz, sinusoidal wave, 6 s), the synchronized bursting activity was increased in the 400 mT-exposed group. On the other hand, no change was observed in the 50–200 mT-exposed groups. In order to clarify the mechanisms of the 400 mT hPF-MF exposure-induced neuronal response, we evaluated it after blocking inhibitory synapses using bicuculline methiodide (BMI); subsequently, increase in bursting activity was observed with BMI application, and the response of 400 mT hPF-MF exposure disappeared. Therefore, it was suggested that the response of hPF-MF exposure was involved in the inhibitory input. Next, we screened the inhibitory pacemaker-like neuronal activity which showed autonomous 4–10 Hz firing with CNQX and D-AP5 application, and it was confirmed that the activity was reduced after 400 mT hPF-MF exposure. Comparison of these experimental results with estimated values of the induced electric field (E-field) in the culture medium revealed that the change in synchronized bursting activity occurred over 0.3 V/m, which was equivalent to the findings of a previous study that used the external electric fields. In addition, the results suggested that the

Assessing human exposure to power-frequency electric and magnetic fields.

PubMed Central

Kaune, W T

1993-01-01

This paper reviews published literature and current problems relating to the assessment of occupational and residential human exposures to power-frequency electric and magnetic fields. Available occupational exposure data suggest that the class of job titles known as electrical workers may be an effective surrogate for time-weighted-average (TWA) magnetic-field (but not electric-field) exposure. Current research in occupational-exposure assessment is directed to the construction of job-exposure matrices based on electric- and magnetic-field measurements and estimates of worker exposures to chemicals and other factors of interest. Recent work has identified five principal sources of residential magnetic fields: electric power transmission lines, electric power distribution lines, ground currents, home wiring, and home appliances. Existing residential-exposure assessments have used one or more of the following techniques: questionnaires, wiring configuration coding, theoretical field calculations, spot electric- and magnetic-field measurements, fixed-site magnetic-field recordings, personal- exposure measurements, and geomagnetic-field measurements. Available normal-power magnetic-field data for residences differ substantially between studies. It is not known if these differences are due to geographical differences, differences in measurement protocols, or instrumentation differences. Wiring codes and measured magnetic fields (but not electric fields) are associated weakly. Available data suggest, but are far from proving, that spot measurements may be more effective than wire codes as predictors of long-term historical magnetic-field exposure. Two studies find that away-from-home TWA magnetic-field exposures are less variable than at-home exposures. The importance of home appliances as contributors to total residential magnetic-field exposure is not known at this time. It also is not known what characteristics (if any) of residential electric and magnetic fields are

Ultra-high resolution profiles of macular intra-retinal layer thicknesses and associations with visual field defects in primary open angle glaucoma

NASA Astrophysics Data System (ADS)

Chen, Qi; Huang, Shenghai; Ma, Qingkai; Lin, Huiling; Pan, Mengmeng; Liu, Xinting; Lu, Fan; Shen, Meixiao

2017-02-01

The structural characteristics of the outer retinal layers in primary open angle glaucoma (POAG) are still controversial, and these changes, along with those in the inner retinal layers, could have clinical and/or pathophysiological significance. A custom-built ultra-high resolution optical coherence tomography (UHR-OCT) combined with an automated segmentation algorithm can image and measure the eight intra-retinal layers. The purpose of this study is to determine the thickness characteristics of the macular intra-retinal layers, especially the outer layers, in POAG patients. Thirty-four POAG patients (56 eyes) and 33 normal subjects (63 eyes) were enrolled. Thickness profiles of the eight intra-retinal layers along a 6-mm length centred on the fovea at the horizontal and vertical meridians were obtained and the regional thicknesses were compared between two groups. The associations between the thicknesses of each intra-retinal layer and the macular visual field (VF) sensitivity were then analysed. POAG affected not only the inner retinal layers but also the photoreceptor layers and retinal pigment epithelium of the outer retina. However, the VF loss was correlated mainly with the damage of the inner retinal layers. UHR-OCT with automated algorithm is a useful tool in detecting microstructural changes of macula with respect to the progression of glaucoma.

A selective ultrahigh responding high temperature ethanol sensor using TiO2 nanoparticles.

PubMed

Arafat, M M; Haseeb, A S M A; Akbar, Sheikh A

2014-07-28

In this research work, the sensitivity of TiO2 nanoparticles towards C2H5OH, H2 and CH4 gases was investigated. The morphology and phase content of the particles was preserved during sensing tests by prior heat treatment of the samples at temperatures as high as 750 °C and 1000 °C. Field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) analysis were employed to characterize the size, morphology and phase content of the particles. For sensor fabrication, a film of TiO2 was printed on a Au interdigitated alumina substrate. The sensing temperature was varied from 450 °C to 650 °C with varying concentrations of target gases. Results show that the sensor has ultrahigh response towards ethanol (C2H5OH) compared to hydrogen (H2) and methane (CH4). The optimum sensing temperature was found to be 600 °C. The response and recovery times of the sensor are 3 min and 15 min, respectively, for 20 ppm C2H5OH at the optimum operating temperature of 600 °C. It is proposed that the catalytic action of TiO2 with C2H5OH is the reason for the ultrahigh response of the sensor.

A Selective Ultrahigh Responding High Temperature Ethanol Sensor Using TiO2 Nanoparticles

PubMed Central

Arafat, M. M.; Haseeb, A. S. M. A.; Akbar, Sheikh A.

2014-01-01

In this research work, the sensitivity of TiO2 nanoparticles towards C2H5OH, H2 and CH4 gases was investigated. The morphology and phase content of the particles was preserved during sensing tests by prior heat treatment of the samples at temperatures as high as 750 °C and 1000 °C. Field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) analysis were employed to characterize the size, morphology and phase content of the particles. For sensor fabrication, a film of TiO2 was printed on a Au interdigitated alumina substrate. The sensing temperature was varied from 450 °C to 650 °C with varying concentrations of target gases. Results show that the sensor has ultrahigh response towards ethanol (C2H5OH) compared to hydrogen (H2) and methane (CH4). The optimum sensing temperature was found to be 600 °C. The response and recovery times of the sensor are 3 min and 15 min, respectively, for 20 ppm C2H5OH at the optimum operating temperature of 600 °C. It is proposed that the catalytic action of TiO2 with C2H5OH is the reason for the ultrahigh response of the sensor. PMID:25072346

Ultra-High Temperature Materials Characterization for Space and Missile Applications

NASA Technical Reports Server (NTRS)

Rogers, Jan; Hyers, Robert

2007-01-01

Numerous advanced space and missile technologies including propulsion systems require operations at high temperatures. Some very high-temperature materials are being developed to meet these needs, including refractory metal alloys, carbides, borides, and silicides. System design requires data for materials properties at operating temperatures. Materials property data are not available at the desired operating temperatures for many materials of interest. The objective of this work is to provide important physical property data at ultra-high temperatures. The MSFC Electrostatic Levitation (ESL) facility can provide measurements of thermophysical properties which include: creep strength, emissivity, density and thermal expansion. ESL uses electrostatic fields to position samples between electrodes during processing and characterization experiments. Samples float between the electrodes during studies and are free from any contact with a container or test apparatus. This provides a high purity environment for the study of high-temperature, reactive materials. ESL can be used to process a wide variety of materials including metals, alloys, ceramics, glasses and semiconductors. A system for the determination of total hemispherical emissivity is being developed for the MSFC ESL facility by AZ Technology Inc. The instrument has been designed to provide emissivity measurements for samples during ESL experiments over the temperature range 700-3400K. A novel non-contact technique for the determination of high-temperature creep strength has been developed. Data from selected ESL-based characterization studies will be presented. The ESL technique could advance space and missile technologies by advancing the knowledge base and the technology readiness level for ultra-high temperature materials. Applications include non-eroding nozzle materials and lightweight, high-temperature alloys for turbines and structures.

Inactivation of Lactobacillus plantarum in apple cider using radio frequency electric fields

USDA-ARS?s Scientific Manuscript database

Radio frequency electric fields (RFEF) processing is effective at inactivating Gram negative bacteria in fruit juices at moderately low temperatures, but has yet to be shown to be effective at reducing Gram positive bacteria. Lactobacillus plantarum ATCC 49445, a Gram positive bacterium, was inocula...

The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review.

PubMed

Glenthøj, Louise Birkedal; Hjorthøj, Carsten; Kristensen, Tina Dam; Davidson, Charlie Andrew; Nordentoft, Merete

2017-01-01

Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional improvements. This study systematically reviewed the evidence on the effectiveness of cognitive remediation in the ultra-high risk population. The electronic databases MEDLINE, PsycINFO, and Embase were searched using keywords related to cognitive remediation and the UHR state. Studies were included if they were peer-reviewed, written in English, and included a population meeting standardized ultra-high risk criteria. Six original research articles were identified. All the studies provided computerized, bottom-up-based cognitive remediation, predominantly targeting neurocognitive function. Four out of five studies that reported a cognitive outcome found cognitive remediation to improve cognition in the domains of verbal memory, attention, and processing speed. Two out of four studies that reported on functional outcome found cognitive remediation to improve the functional outcome in the domains of social functioning and social adjustment. Zero out of the five studies that reported such an outcome found cognitive remediation to affect the magnitude of clinical symptoms. Research on the effect of cognitive remediation in the ultra-high risk state is still scarce. The current state of evidence indicates an effect of cognitive remediation on cognition and functioning in ultra-high risk individuals. More research on cognitive remediation in ultra-high risk is needed, notably in large-scale trials assessing the effect of neurocognitive and/or social cognitive remediation on multiple outcomes.

Velocity field measurements on high-frequency, supersonic microactuators

NASA Astrophysics Data System (ADS)

Kreth, Phillip A.; Ali, Mohd Y.; Fernandez, Erik J.; Alvi, Farrukh S.

2016-05-01

The resonance-enhanced microjet actuator which was developed at the Advanced Aero-Propulsion Laboratory at Florida State University is a fluidic-based device that produces pulsed, supersonic microjets by utilizing a number of microscale, flow-acoustic resonance phenomena. The microactuator used in this study consists of an underexpanded source jet that flows into a cylindrical cavity with a single, 1-mm-diameter exhaust orifice through which an unsteady, supersonic jet issues at a resonant frequency of 7 kHz. The flowfields of a 1-mm underexpanded free jet and the microactuator are studied in detail using high-magnification, phase-locked flow visualizations (microschlieren) and two-component particle image velocimetry. These are the first direct measurements of the velocity fields produced by such actuators. Comparisons are made between the flow visualizations and the velocity field measurements. The results clearly show that the microactuator produces pulsed, supersonic jets with velocities exceeding 400 m/s for roughly 60 % of their cycles. With high unsteady momentum output, this type of microactuator has potential in a range of ow control applications.

Performance of field-emitting resonating carbon nanotubes as radio-frequency demodulators

NASA Astrophysics Data System (ADS)

Vincent, P.; Poncharal, P.; Barois, T.; Perisanu, S.; Gouttenoire, V.; Frachon, H.; Lazarus, A.; de Langre, E.; Minoux, E.; Charles, M.; Ziaei, A.; Guillot, D.; Choueib, M.; Ayari, A.; Purcell, S. T.

2011-04-01

We report on a systematic study of the use of resonating nanotubes in a field emission (FE) configuration to demodulate radio frequency signals. We particularly concentrate on how the demodulation depends on the variation of the field amplification factor during resonance. Analytical formulas describing the demodulation are derived as functions of the system parameters. Experiments using AM and FM demodulations in a transmission electron microscope are also presented with a determination of all the pertinent experimental parameters. Finally we discuss the use of CNTs undergoing FE as nanoantennae and the different geometries that could be used for optimization and implementation.

Processing of fibre suspensions at ultra-high consistencies

Treesearch

Daniel F. Caulfield; Rodney E. Jacobson

2004-01-01

Typically the paper physicist considers pulp suspensions greater than 0.5% consistency as high consistency. In our research on cellulose fibre- reinforced engineering plastics we have had to develop a two-step method for the processing of fibers suspensions at ultrahigh consistencies (consistencies greater than 30%).

Rescue of Moribund Chicken Embryos by Extremely Low-Frequency Electric Fields.

PubMed

Cooper, Peter D

Modern living is awash with low-frequency electromagnetic radiation raising concern over health effects, birth defects, and infant cancers especially leukemias. Medical/scientific opinion is ambivalent, especially regarding possible mechanisms of action despite our bodies׳ many electric currents. Are some cancers induced by morphogenetic changes rather than direct mutation? We wished to see if morphogenetic effects of weak, extremely low-frequency electric (ELF) fields in embryonated hen׳s eggs could induce cancers, knowing that such treatment is usually deleterious. We report a pilot study intended to reveal a promising cell source in which to search for cancer cells by established methods and then to check for DNA damage. Stored (5°C for 1-36 days) fresh, fertile hens׳ eggs were incubated (38°C, total five or six days) in presence or absence of a weak ELF oscillating electric field (1-40V/cm, 1-50Hz and two to six days). Separated embryos were assessed for development stage. Storage of untreated eggs (>12 days, 5°C) allows a steady loss of normal embryo formation at 38°C (few viable by 25 days, half-life ~18 days). Surprisingly, incubation in a weak ELF field during the period of declining viability significantly (P: 0.03-0.0001) improved viability and condition of the embryos (new half-life ~21 days), rather than the expected converse. Thus for a few days, the field could keep viable some embryos that would otherwise not have survived. The rescued embryos and their untreated controls seem the most promising place to seek any carcinogenic effects of ELF fields. The nature of the presumed critical component keeping them viable during 5°C storage is at least of equal interest. Copyright © 2016 Elsevier Inc. All rights reserved.

Thermal noise limit for ultra-high vacuum noncontact atomic force microscopy.

PubMed

Lübbe, Jannis; Temmen, Matthias; Rode, Sebastian; Rahe, Philipp; Kühnle, Angelika; Reichling, Michael

2013-01-01

The noise of the frequency-shift signal Δf in noncontact atomic force microscopy (NC-AFM) consists of cantilever thermal noise, tip-surface-interaction noise and instrumental noise from the detection and signal processing systems. We investigate how the displacement-noise spectral density d(z) at the input of the frequency demodulator propagates to the frequency-shift-noise spectral density d(Δ) (f) at the demodulator output in dependence of cantilever properties and settings of the signal processing electronics in the limit of a negligible tip-surface interaction and a measurement under ultrahigh-vacuum conditions. For a quantification of the noise figures, we calibrate the cantilever displacement signal and determine the transfer function of the signal-processing electronics. From the transfer function and the measured d(z), we predict d(Δ) (f) for specific filter settings, a given level of detection-system noise spectral density d(z) (ds) and the cantilever-thermal-noise spectral density d(z) (th). We find an excellent agreement between the calculated and measured values for d(Δ) (f). Furthermore, we demonstrate that thermal noise in d(Δ) (f), defining the ultimate limit in NC-AFM signal detection, can be kept low by a proper choice of the cantilever whereby its Q-factor should be given most attention. A system with a low-noise signal detection and a suitable cantilever, operated with appropriate filter and feedback-loop settings allows room temperature NC-AFM measurements at a low thermal-noise limit with a significant bandwidth.

Thermal noise limit for ultra-high vacuum noncontact atomic force microscopy

PubMed Central

Lübbe, Jannis; Temmen, Matthias; Rode, Sebastian; Rahe, Philipp; Kühnle, Angelika

2013-01-01

Summary The noise of the frequency-shift signal Δf in noncontact atomic force microscopy (NC-AFM) consists of cantilever thermal noise, tip–surface-interaction noise and instrumental noise from the detection and signal processing systems. We investigate how the displacement-noise spectral density d z at the input of the frequency demodulator propagates to the frequency-shift-noise spectral density d Δ f at the demodulator output in dependence of cantilever properties and settings of the signal processing electronics in the limit of a negligible tip–surface interaction and a measurement under ultrahigh-vacuum conditions. For a quantification of the noise figures, we calibrate the cantilever displacement signal and determine the transfer function of the signal-processing electronics. From the transfer function and the measured d z, we predict d Δ f for specific filter settings, a given level of detection-system noise spectral density d z ds and the cantilever-thermal-noise spectral density d z th. We find an excellent agreement between the calculated and measured values for d Δ f. Furthermore, we demonstrate that thermal noise in d Δ f, defining the ultimate limit in NC-AFM signal detection, can be kept low by a proper choice of the cantilever whereby its Q-factor should be given most attention. A system with a low-noise signal detection and a suitable cantilever, operated with appropriate filter and feedback-loop settings allows room temperature NC-AFM measurements at a low thermal-noise limit with a significant bandwidth. PMID:23400758

Radio-frequency measurements of UNiX compounds (X=Al, Ga, Ge) in high magnetic fields

NASA Astrophysics Data System (ADS)

Alsmadi, A. M.; Alyones, S.; Mielke, C. H.; McDonald, R. D.; Zapf, V.; Altarawneh, M. M.; Lacerda, A.; Chang, S.; Adak, S.; Kothapalli, K.; Nakotte, H.

2009-11-01

We performed radio-frequency (RF) skin-depth measurements of antiferromagnetic UNiX compounds (X=Al, Ga, Ge) in magnetic fields up to 60 T and at temperatures between 1.4 to ~60 K. Magnetic fields are applied along different crystallographic directions and RF penetration-depth was measured using a tunnel-diode oscillator (TDO) circuit. The sample is coupled to the inductive element of a TDO resonant tank circuit, and the shift in the resonant frequency Δ f of the circuit is measured. The UNiX compounds exhibit field-induced magnetic transitions at low temperatures, and those transitions are accompanied by a drastic change in Δ f. The results of our skin-depth measurements were compared with previously published B- T phase diagrams for these three compounds.

Radiometric measurements over bare and vegetated fields at 1.4 GHz and 5 GHz frequencies. [Beltsville Agricultural Research Center, Maryland

NASA Technical Reports Server (NTRS)

Wang, J. R.; Mcmurtrey, J. E., III; Engman, E. T.; Jackson, T. J.; Schmugge, T. J.; Gould, W. I.; Glazar, W. S.; Fuchs, J. E. (Principal Investigator)

1981-01-01

Microwave emission from bare and vegetated fields was measured with dual polarized radiometers at 1.4 GHz and 5 GHz frequencies. The measured brightness temperatures over bare fields are shown to compare favorably with those calculated from radiative transfer theory with two constant parameters characterizing surface roughness effect. The presence of vegetation cover is found to reduce the sensitivity to soil moisture variation. This sensitivity reduction is generally pronounced the denser, the vegetation cover and the higher the frequency of observation. The effect of vegetation cover is also examined with respect to the measured polarization factor at both frequencies. With the exception of dry corn fields, the measured polarization factor over vegetated fields is found appreciably reduced compared to that over bare fields. A much larger reduction in this factor is found at 5GHz than at 1.4GHz frequency.

An improved oxygen diffusion model to explain the effect of low-temperature baking on high field losses in niobium superconducting cavities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ciovati, Gianluigi

Radio-frequency (RF) superconducting cavities made of high purity niobium are widely used to accelerate charged particle beams in particle accelerators. The major limitation to achieve RF field values approaching the theoretical limit for niobium is represented by ''anomalous'' losses which degrade the quality factor of the cavities starting at peak surface magnetic fields of about 100 mT, in absence of field emission. These high field losses are often referred to as ''Q-drop''. It has been observed that the Q-drop is drastically reduced by baking the cavities at 120 C for about 48 h under ultrahigh vacuum. An improved oxygen diffusionmore » model for the niobium-oxide system is proposed to explain the benefit of the low-temperature baking on the Q-drop in niobium superconducting rf cavities. The model shows that baking at 120 C for 48 h allows oxygen to diffuse away from the surface, and therefore increasing the lower critical field towards the value for pure niobium.« less

Refined tip preparation by electrochemical etching and ultrahigh vacuum treatment to obtain atomically sharp tips for scanning tunneling microscope and atomic force microscope.

PubMed

Hagedorn, Till; El Ouali, Mehdi; Paul, William; Oliver, David; Miyahara, Yoichi; Grütter, Peter

2011-11-01

A modification of the common electrochemical etching setup is presented. The described method reproducibly yields sharp tungsten tips for usage in the scanning tunneling microscope and tuning fork atomic force microscope. In situ treatment under ultrahigh vacuum (p ≤10(-10) mbar) conditions for cleaning and fine sharpening with minimal blunting is described. The structure of the microscopic apex of these tips is atomically resolved with field ion microscopy and cross checked with field emission. © 2011 American Institute of Physics

The propagation characteristics of electromagnetic waves through plasma in the near-field region of low-frequency loop antenna

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, DongLin, E-mail: donglinliu@stu.xidian.edu.cn; Li, XiaoPing; Xie, Kai

2015-10-15

A high-speed vehicle flying through the atmosphere between 100 and 20 km may suffer from a “communication blackout.” In this paper, a low frequency system with an on-board loop antenna to receive signals is presented as a potential blackout mitigation method. Because the plasma sheath is in the near-field region of the loop antenna, the traditional scattering matrix method that is developed for the far-field region may overestimate the electromagnetic (EM) wave's attenuation. To estimate the EM wave's attenuation in the near-field region, EM interference (EMI) shielding theory is introduced. Experiments are conducted, and the results verify the EMI shielding theory'smore » effectiveness. Simulations are also conducted with different plasma parameters, and the results obtained show that the EM wave's attenuation in the near-field region is far below than that in the far-field region. The EM wave's attenuation increases with the increase in electron density and decreases with the increase in collision frequency. The higher the frequency, the larger is the EM wave's attenuation. During the entire re-entry phase of a RAM-C module, the EM wave's attenuations are below 10 dB for EM waves with a frequency of 1 MHz and below 1 dB for EM waves with a frequency of 100 kHz. Therefore, the low frequency systems (e.g., Loran-C) may provide a way to transmit some key information to high-speed vehicles even during the communication “blackout” period.« less

Assessment of extremely low frequency magnetic field exposure from GSM mobile phones.

PubMed

Calderón, Carolina; Addison, Darren; Mee, Terry; Findlay, Richard; Maslanyj, Myron; Conil, Emmanuelle; Kromhout, Hans; Lee, Ae-kyoung; Sim, Malcolm R; Taki, Masao; Varsier, Nadège; Wiart, Joe; Cardis, Elisabeth

2014-04-01

Although radio frequency (RF) electromagnetic fields emitted by mobile phones have received much attention, relatively little is known about the extremely low frequency (ELF) magnetic fields emitted by phones. This paper summarises ELF magnetic flux density measurements on global system for mobile communications (GSM) mobile phones, conducted as part of the MOBI-KIDS epidemiological study. The main challenge is to identify a small number of generic phone models that can be used to classify the ELF exposure for the different phones reported in the study. Two-dimensional magnetic flux density measurements were performed on 47 GSM mobile phones at a distance of 25 mm. Maximum resultant magnetic flux density values at 217 Hz had a geometric mean of 221 (+198/-104) nT. Taking into account harmonic data, measurements suggest that mobile phones could make a substantial contribution to ELF exposure in the general population. The maximum values and easily available variables were poorly correlated. However, three groups could be defined on the basis of field pattern indicating that manufacturers and shapes of mobile phones may be the important parameters linked to the spatial characteristics of the magnetic field, and the categorization of ELF magnetic field exposure for GSM phones in the MOBI-KIDS study may be achievable on the basis of a small number of representative phones. Such categorization would result in a twofold exposure gradient between high and low exposure based on type of phone used, although there was overlap in the grouping. © 2013 Wiley Periodicals, Inc.

Mechanical flip-chip for ultra-high electron mobility devices

DOE PAGES

Bennaceur, Keyan; Schmidt, Benjamin A.; Gaucher, Samuel; ...

2015-09-22

In this study, electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC), electron interferometers and quantum dots. To fabricate these gates, processing is usually performed on the 2DEG material, which is in many cases detrimental to its electron mobility. Here we propose an alternative process which does not require any processing of the 2DEG material other than for the ohmic contacts. Thismore » approach relies on processing a separate wafer that is then mechanically mounted on the 2DEG material in a flip-chip fashion. This technique proved successful to fabricate quantum point contacts on both GaAs/AlGaAs materials with both moderate and ultra-high electron mobility.« less

[Electric traction magnetic fields of ultra-low frequency as an occupational risk factor of ischemic heart disease].

PubMed

Ptitsyna, N G; Kudrin, V A; Villorezi, D; Kopytenko, Iu A; Tiasto, M I; Kopytenko, E A; Bochko, V A; Iuchchi, N

1996-01-01

The study was inspired by earlier results that displayed influence of variable natural geomagnetic field (0.005-10 Hz range-ultra-low frequencies) on circulatory system, indicated possible correlation between industrial ultra-low frequency fields and prevalence of myocardial infarction. The authors conducted unique measurements of ultra-low frequency fields produced by electric engines. The results were compared with data on morbidity among railway transport workers. The findings are that level of magnetic variations in electric locomotive cabin can exceed 280 micro Tesla, whereas that in car sections reaches 50 micro Tesla. Occurrence of coronary heart disease among the locomotive operators appeared to be 2.0 + 0.2 times higher than that among the car section operators. Higher risk of coronary heart disease in the locomotive operators is associated with their increased occupational magnetic load.

Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies

PubMed Central

Zimmerman, Jacquelyn W.; Jimenez, Hugo; Pennison, Michael J.; Brezovich, Ivan; Morgan, Desiree; Mudry, Albert; Costa, Frederico P.; Barbault, Alexandre; Pasche, Boris

2013-01-01

In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer. PMID:24206915

Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies.

PubMed

Zimmerman, Jacquelyn W; Jimenez, Hugo; Pennison, Michael J; Brezovich, Ivan; Morgan, Desiree; Mudry, Albert; Costa, Frederico P; Barbault, Alexandre; Pasche, Boris

2013-11-01

In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer.

Evaluation and characterization of fetal exposures to low frequency magnetic fields generated by laptop computers.

PubMed

Zoppetti, Nicola; Andreuccetti, Daniele; Bellieni, Carlo; Bogi, Andrea; Pinto, Iole

2011-12-01

Portable - or "laptop" - computers (LCs) are widely and increasingly used all over the world. Since LCs are often used in tight contact with the body even by pregnant women, fetal exposures to low frequency magnetic fields generated by these units can occur. LC emissions are usually characterized by complex waveforms and are often generated by the main AC power supply (when connected) and by the display power supply sub-system. In the present study, low frequency magnetic field emissions were measured for a set of five models of portable computers. For each of them, the magnetic flux density was characterized in terms not just of field amplitude, but also of the so called "weighted peak" (WP) index, introduced in the 2003 ICNIRP Statement on complex waveforms and confirmed in the 2010 ICNIRP Guidelines for low frequency fields. For the model of LC presenting the higher emission, a deeper analysis was also carried out, using numerical dosimetry techniques to calculate internal quantities (current density and in-situ electric field) with reference to a digital body model of a pregnant woman. Since internal quantities have complex waveforms too, the concept of WP index was extended to them, considering the ICNIRP basic restrictions defined in the 1998 Guidelines for the current density and in the 2010 Guidelines for the in-situ electric field. Induced quantities and WP indexes were computed using an appropriate original formulation of the well known Scalar Potential Finite Difference (SPFD) numerical method for electromagnetic dosimetry in quasi-static conditions. Copyright © 2011 Elsevier Ltd. All rights reserved.

Review of Studies Concerning Electromagnetic Field (EMF) Exposure Assessment in Europe: Low Frequency Fields (50 Hz–100 kHz)

PubMed Central

Gajšek, Peter; Ravazzani, Paolo; Grellier, James; Samaras, Theodoros; Bakos, József; Thuróczy, György

2016-01-01

We aimed to review the findings of exposure assessment studies done in European countries on the exposure of the general public to low frequency electric and magnetic fields (EMFs) of various frequencies. The study shows that outdoor average extremely low frequency magnetic fields (ELF-MF) in public areas in urban environments range between 0.05 and 0.2 µT in terms of flux densities, but stronger values (of the order of a few µT) may occur directly beneath high-voltage power lines, at the walls of transformer buildings, and at the boundary fences of substations. In the indoor environment, high values have been measured close to several domestic appliances (up to the mT range), some of which are held close to the body, e.g., hair dryers, electric shavers. Common sources of exposure to intermediate frequencies (IF) include induction cookers, compact fluorescent lamps, inductive charging systems for electric cars and security or anti-theft devices. No systematic measurement surveys or personal exposimetry data for the IF range have been carried out and only a few reports on measurements of EMFs around such devices are mentioned. According to the available European exposure assessment studies, three population exposure categories were classified by the authors regarding the possible future risk analysis. This classification should be considered a crucial advancement for exposure assessment, which is a mandatory step in any future health risk assessment of EMFs exposure. PMID:27598182

Review of Studies Concerning Electromagnetic Field (EMF) Exposure Assessment in Europe: Low Frequency Fields (50 Hz-100 kHz).

PubMed

Gajšek, Peter; Ravazzani, Paolo; Grellier, James; Samaras, Theodoros; Bakos, József; Thuróczy, György

2016-09-01

We aimed to review the findings of exposure assessment studies done in European countries on the exposure of the general public to low frequency electric and magnetic fields (EMFs) of various frequencies. The study shows that outdoor average extremely low frequency magnetic fields (ELF-MF) in public areas in urban environments range between 0.05 and 0.2 µT in terms of flux densities, but stronger values (of the order of a few µT) may occur directly beneath high-voltage power lines, at the walls of transformer buildings, and at the boundary fences of substations. In the indoor environment, high values have been measured close to several domestic appliances (up to the mT range), some of which are held close to the body, e.g., hair dryers, electric shavers. Common sources of exposure to intermediate frequencies (IF) include induction cookers, compact fluorescent lamps, inductive charging systems for electric cars and security or anti-theft devices. No systematic measurement surveys or personal exposimetry data for the IF range have been carried out and only a few reports on measurements of EMFs around such devices are mentioned. According to the available European exposure assessment studies, three population exposure categories were classified by the authors regarding the possible future risk analysis. This classification should be considered a crucial advancement for exposure assessment, which is a mandatory step in any future health risk assessment of EMFs exposure.

Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography.

PubMed

Herz, P R; Chen, Y; Aguirre, A D; Schneider, K; Hsiung, P; Fujimoto, J G; Madden, K; Schmitt, J; Goodnow, J; Petersen, C

2004-10-01

A distally actuated, rotational-scanning micromotor endoscope catheter probe is demonstrated for ultrahigh-resolution in vivo endoscopic optical coherence tomography (OCT) imaging. The probe permits focus adjustment for visualization of tissue morphology at varying depths with improved transverse resolution compared with standard OCT imaging probes. The distal actuation avoids nonuniform scanning motion artifacts that are present with other probe designs and can permit a wider range of imaging speeds. Ultrahigh-resolution endoscopic imaging is demonstrated in a rabbit with <4-microm axial resolution by use of a femtosecond Cr:forsterite laser light source. The micromotor endoscope catheter probe promises to improve OCT imaging performance in future endoscopic imaging applications.

Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography

NASA Astrophysics Data System (ADS)

Herz, P. R.; Chen, Y.; Aguirre, A. D.; Schneider, K.; Hsiung, P.; Fujimoto, J. G.; Madden, K.; Schmitt, J.; Goodnow, J.; Petersen, C.

2004-10-01

A distally actuated, rotational-scanning micromotor endoscope catheter probe is demonstrated for ultrahigh-resolution in vivo endoscopic optical coherence tomography (OCT) imaging. The probe permits focus adjustment for visualization of tissue morphology at varying depths with improved transverse resolution compared with standard OCT imaging probes. The distal actuation avoids nonuniform scanning motion artifacts that are present with other probe designs and can permit a wider range of imaging speeds. Ultrahigh-resolution endoscopic imaging is demonstrated in a rabbit with <4-µm axial resolution by use of a femtosecond Crforsterite laser light source. The micromotor endoscope catheter probe promises to improve OCT imaging performance in future endoscopic imaging applications.

Ultrahigh-Density Nanowire Arrays Grown in Self-Assembled Diblock Copolymer Templates

NASA Astrophysics Data System (ADS)

Thurn-Albrecht, T.; Schotter, J.; Kästle, G. A.; Emley, N.; Shibauchi, T.; Krusin-Elbaum, L.; Guarini, K.; Black, C. T.; Tuominen, M. T.; Russell, T. P.

2000-12-01

We show a simple, robust, chemical route to the fabrication of ultrahigh-density arrays of nanopores with high aspect ratios using the equilibrium self-assembled morphology of asymmetric diblock copolymers. The dimensions and lateral density of the array are determined by segmental interactions and the copolymer molecular weight. Through direct current electrodeposition, we fabricated vertical arrays of nanowires with densities in excess of 1.9 × 1011 wires per square centimeter. We found markedly enhanced coercivities with ferromagnetic cobalt nanowires that point toward a route to ultrahigh-density storage media. The copolymer approach described is practical, parallel, compatible with current lithographic processes, and amenable to multilayered device fabrication.

Ultrahigh-density nanowire arrays grown in self-assembled diblock copolymer templates.

PubMed

Thurn-Albrecht, T; Schotter, J; Kästle, G A; Emley, N; Shibauchi, T; Krusin-Elbaum, L; Guarini, K; Black, C T; Tuominen, M T; Russell, T P

2000-12-15

We show a simple, robust, chemical route to the fabrication of ultrahigh-density arrays of nanopores with high aspect ratios using the equilibrium self-assembled morphology of asymmetric diblock copolymers. The dimensions and lateral density of the array are determined by segmental interactions and the copolymer molecular weight. Through direct current electrodeposition, we fabricated vertical arrays of nanowires with densities in excess of 1.9 x 10(11) wires per square centimeter. We found markedly enhanced coercivities with ferromagnetic cobalt nanowires that point toward a route to ultrahigh-density storage media. The copolymer approach described is practical, parallel, compatible with current lithographic processes, and amenable to multilayered device fabrication.

Development of High Frequency Transition-Edge-Sensor Polarimeters for Next Generation Cosmic Microwave Background Experiments and Galactic Foreground Measurements

NASA Astrophysics Data System (ADS)

Walker, Samantha; Sierra, Carlos E.; Austermann, Jason Edward; Beall, James; Becker, Dan; Dober, Bradley; Duff, Shannon; Hilton, Gene; Hubmayr, Johannes; Van Lanen, Jeffrey L.; McMahon, Jeff; Simon, Sara M.; Ullom, Joel; Vissers, Michael R.; NIST Quantum Sensors Group

2018-06-01

Observations of the cosmic microwave background (CMB) provide a powerful tool for probing the earliest moments of the universe and therefore have the potential to transform our understanding of cosmology. In particular, precision measurements of its polarization can reveal the existence of gravitational waves produced during cosmic inflation. However, these observations are complicated by the presence of astrophysical foregrounds, which may be separated by using broad frequency coverage, as the spectral energy distribution between foregrounds and the CMB is distinct. For this purpose, we are developing large-bandwidth, feedhorn-coupled transition-edge-sensor (TES) arrays that couple polarized light from waveguide to superconducting microstrip by use of a symmetric, planar orthomode transducer (OMT). In this work, we describe two types of pixels, an ultra-high frequency (UHF) design, which operates from 195 GHz-315 GHz, and an extended ultra-high frequency (UHF++) design, which operates from 195 GHz-420 GHz, being developed for next generation CMB experiments that will come online in the next decade, such as CCAT-prime and the Simons Observatory. We present the designs, simulation results, fabrication, and preliminary measurements of these prototype pixels.

Imaging of the interaction of low frequency electric fields with biological tissues by optical coherence tomography

NASA Astrophysics Data System (ADS)

Peña, Adrian F.; Devine, Jack; Doronin, Alexander; Meglinski, Igor

2014-03-01

We report the use of conventional Optical Coherence Tomography (OCT) for visualization of propagation of low frequency electric field in soft biological tissues ex vivo. To increase the overall quality of the experimental images an adaptive Wiener filtering technique has been employed. Fourier domain correlation has been subsequently applied to enhance spatial resolution of images of biological tissues influenced by low frequency electric field. Image processing has been performed on Graphics Processing Units (GPUs) utilizing Compute Unified Device Architecture (CUDA) framework in the frequencydomain. The results show that variation in voltage and frequency of the applied electric field relates exponentially to the magnitude of its influence on biological tissue. The magnitude of influence is about twice more for fresh tissue samples in comparison to non-fresh ones. The obtained results suggest that OCT can be used for observation and quantitative evaluation of the electro-kinetic changes in biological tissues under different physiological conditions, functional electrical stimulation, and potentially can be used non-invasively for food quality control.

Survival of Chinese Hamster Ovary Cells Following Ultrahigh Dose Rate Electron and Bremsstrahlung Radiation

DTIC Science & Technology

1990-04-01

and a stepped lead flattening filter. The electron energy used for these studies was 13 MeV. Dosimetry was performed by the Health Physics Division...VolI LJSAFSAPA-TR-90-4 AD-A222 722 SURVIVAL OF CHINESE HAMSTER OVARY CELLS FOLLOWING ULTRAHIGH DOSE RATE ELECTRON AND BREMISSTRAHLUNG RADIATION...Include Security ;a!. iatcn) Survival of Chinese Hamster Ovary Cells Following Ultrahigh Dose Rate Electron and Bremsstrahlung Radiation 12 PERSONAL

Spatially-Resolved Characterization Techniques to Investigate Impact Damage in Ultra-High Performance Concretes

DTIC Science & Technology

2013-04-01

Concretes G eo te ch n ic al a n d S tr u ct u re s La b or at or y Robert D. Moser, Paul G. Allison, and Mei Q. Chandler April 2013 Approved...Impact Damage in Ultra-High Performance Concretes Robert D. Moser, Paul G. Allison, and Mei Q. Chandler Geotechnical and Structures Laboratory US...Portland Cement concrete (OPC) and Ultra-High Performance Concretes (UHPCs) under high-strain impact and penetration loads at lower length scales

Time resolved dosimetry of human brain exposed to low frequency pulsed magnetic fields.

PubMed

Paffi, Alessandra; Camera, Francesca; Lucano, Elena; Apollonio, Francesca; Liberti, Micaela

2016-06-21

An accurate dosimetry is a key issue to understanding brain stimulation and related interaction mechanisms with neuronal tissues at the basis of the increasing amount of literature revealing the effects on human brain induced by low-level, low frequency pulsed magnetic fields (PMFs). Most literature on brain dosimetry estimates the maximum E field value reached inside the tissue without considering its time pattern or tissue dispersivity. Nevertheless a time-resolved dosimetry, accounting for dispersive tissues behavior, becomes necessary considering that the threshold for an effect onset may vary depending on the pulse waveform and that tissues may filter the applied stimulatory fields altering the predicted stimulatory waveform's size and shape. In this paper a time-resolved dosimetry has been applied on a realistic brain model exposed to the signal presented in Capone et al (2009 J. Neural Transm. 116 257-65), accounting for the broadband dispersivity of brain tissues up to several kHz, to accurately reconstruct electric field and current density waveforms inside different brain tissues. The results obtained by exposing the Duke's brain model to this PMF signal show that the E peak in the brain is considerably underestimated if a simple monochromatic dosimetry is carried out at the pulse repetition frequency of 75 Hz.

Time resolved dosimetry of human brain exposed to low frequency pulsed magnetic fields

NASA Astrophysics Data System (ADS)

Paffi, Alessandra; Camera, Francesca; Lucano, Elena; Apollonio, Francesca; Liberti, Micaela

2016-06-01

An accurate dosimetry is a key issue to understanding brain stimulation and related interaction mechanisms with neuronal tissues at the basis of the increasing amount of literature revealing the effects on human brain induced by low-level, low frequency pulsed magnetic fields (PMFs). Most literature on brain dosimetry estimates the maximum E field value reached inside the tissue without considering its time pattern or tissue dispersivity. Nevertheless a time-resolved dosimetry, accounting for dispersive tissues behavior, becomes necessary considering that the threshold for an effect onset may vary depending on the pulse waveform and that tissues may filter the applied stimulatory fields altering the predicted stimulatory waveform’s size and shape. In this paper a time-resolved dosimetry has been applied on a realistic brain model exposed to the signal presented in Capone et al (2009 J. Neural Transm. 116 257-65), accounting for the broadband dispersivity of brain tissues up to several kHz, to accurately reconstruct electric field and current density waveforms inside different brain tissues. The results obtained by exposing the Duke’s brain model to this PMF signal show that the E peak in the brain is considerably underestimated if a simple monochromatic dosimetry is carried out at the pulse repetition frequency of 75 Hz.

Ultrahigh Pressure Dynamic Compression

NASA Astrophysics Data System (ADS)

Duffy, T. S.

2017-12-01

Laser-based dynamic compression provides a new opportunity to study the lattice structure and other properties of geological materials to ultrahigh pressure conditions ranging from 100 - 1000 GPa (1 TPa) and beyond. Such studies have fundamental applications to understanding the Earth's core as well as the interior structure of super-Earths and giant planets. This talk will review recent dynamic compression experiments using high-powered lasers on materials including Fe-Si, MgO, and SiC. Experiments were conducted at the Omega laser (University of Rochester) and the Linac Coherent Light Source (LCLS, Stanford). At Omega, laser drives as large as 2 kJ are applied over 10 ns to samples that are 50 microns thick. At peak compression, the sample is probed with quasi-monochromatic X-rays from a laser-plasma source and diffraction is recorded on image plates. At LCLS, shock waves are driven into the sample using a 40-J laser with a 10-ns pulse. The sample is probed with X-rays form the LCLS free electron laser providing 1012 photons in a monochromatic pulse near 10 keV energy. Diffraction is recorded using pixel array detectors. By varying the delay between the laser and the x-ray beam, the sample can be probed at various times relative to the shock wave transiting the sample. By controlling the shape and duration of the incident laser pulse, either shock or ramp (shockless) loading can be produced. Ramp compression produces less heating than shock compression, allowing samples to be probed to ultrahigh pressures without melting. Results for iron alloys, oxides, and carbides provide new constraints on equations of state and phase transitions that are relevant to the interior structure of large, extrasolar terrestrial-type planets.

Radio-frequency measurements of UNiX compounds (X= Al, Ga, Ge) in high magnetic fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mielke, Charles H; Mcdonald, David R; Zapf, Vivien

2009-01-01

We performed radio-frequency (RF) skin-depth measurements of antiferromagnetic UNiX compounds (X=Al, Ga, Ge) in magnetic fields up to 60 T and at temperatures between 1.4 to {approx}60 K. Magnetic fields are applied along different crystallographic directions and RF penetration-depth was measured using a tunnel-diode oscillator (TDO) circuit. The sample is coupled to the inductive element of a TDO resonant tank circuit, and the shift in the resonant frequency {Delta}f of the circuit is measured. The UNiX compounds exhibit field-induced magnetic transitions at low temperatures, and those transitions are accompanied by a drastic change in {Delta}f. The results of our skin-depthmore » measurements were compared with previously published B-T phase diagrams for these three compounds.« less

[Comparative assessment of MR-semiotics of acutest intracerebral hematomas in low- and extra high-field frequency magnetic resonance tomography].

PubMed

Skvortsova, V I; Burenchev, D V; Tvorogova, T V; Guseva, O I; Prokhorov, A V; Smirnov, A M; Kupriianov, D A; Pirogov, Iu A

2009-01-01

An objective of the study was to compare sensitivity of low- and extra high-field frequency magnetic resonance (MR) tomography of acutest intracerebral hematomas (ICH) and to assess differences between symptoms in obtained images. A study was conducted using experimental ICH in rats (n=6). Hematomas were formed by two injections of autologic blood into the brain. MR-devices "Bio Spec 70/30" with magnetic field strength of 7 T and "Ellipse-150" with magnetic field strength of 0,15 T were used in the study. MR-tomography was carried out 3-5 h after the injections. Both MR-devices revealed the presence of pathological lesion in all animals. Extra highfield frequency MR-tomography showed the specific signs of ICH caused by the paramagnetic effect of deoxyhemoglobin in T2 and T2*-weighted images (WI) and low frequency MR-tomography - in T2*-WI only. The comparable sensitivity of low- and extra high-field frequency MR-devices in acutest ICH was established.

Monitoring Sea Surface Processes Using the High Frequency Ambient Sound Field

DTIC Science & Technology

2006-09-30

Pacific (ITCZ 10ºN, 95ºW), 3) Bering Sea coastal shelf, 4) Ionian Sea, 5) Carr Inlet, Puget Sound , Washington, and 6) Haro Strait, Washington/BC...Southern Resident Killer Whale ( Puget Sound ). In coastal and inland waterways, anthropogenic noise is often present. These signals are usually...Monitoring Sea Surface Processes Using the High Frequency Ambient Sound Field Jeffrey A. Nystuen Applied Physics Laboratory University of

Ultrahigh hydrostatic pressure extraction of flavonoids from Epimedium koreanum Nakai

NASA Astrophysics Data System (ADS)

Hou, Lili; Zhang, Shouqin; Dou, Jianpeng; Zhu, Junjie; Liang, Qing

2011-02-01

Herba Epimedii is one of the most famous Chinese herbal medicines listed in the Pharmacopoeia of the People's Republic of China, as one of the representatives of traditional Chinese herb, it has been widely applied in the field of invigorate the kidney and strengthen 'Yang'. The attention to Epimedium extract has more and more increased in recent years. In this work, a novel extraction technique, ultra-high hydrostatic pressure extraction (UPE) technology was applied to extract the total flavonoids of E. koreanum. Three factors (pressure, ethanol concentration and extraction time) were chosen as the variables of extraction experiments, and the optimum UPE conditions were pressure 350 MPa; ethanol concentration 50% (v/v); extraction time 5 min. Compared with Supercritical CO2 extraction, Reflux extraction and Ultrasonic-assisted extraction, UPE has excellent advantages (shorter extraction time, higher yield, better antioxidant activity, lower energy consumption and eco-friendly).

High-speed light field camera and frequency division multiplexing for fast multi-plane velocity measurements.

PubMed

Fischer, Andreas; Kupsch, Christian; Gürtler, Johannes; Czarske, Jürgen

2015-09-21

Non-intrusive fast 3d measurements of volumetric velocity fields are necessary for understanding complex flows. Using high-speed cameras and spectroscopic measurement principles, where the Doppler frequency of scattered light is evaluated within the illuminated plane, each pixel allows one measurement and, thus, planar measurements with high data rates are possible. While scanning is one standard technique to add the third dimension, the volumetric data is not acquired simultaneously. In order to overcome this drawback, a high-speed light field camera is proposed for obtaining volumetric data with each single frame. The high-speed light field camera approach is applied to a Doppler global velocimeter with sinusoidal laser frequency modulation. As a result, a frequency multiplexing technique is required in addition to the plenoptic refocusing for eliminating the crosstalk between the measurement planes. However, the plenoptic refocusing is still necessary in order to achieve a large refocusing range for a high numerical aperture that minimizes the measurement uncertainty. Finally, two spatially separated measurement planes with 25×25 pixels each are simultaneously acquired with a measurement rate of 0.5 kHz with a single high-speed camera.

Characterization of extremely low frequency magnetic fields from diesel, gasoline and hybrid cars under controlled conditions.

PubMed

Hareuveny, Ronen; Sudan, Madhuri; Halgamuge, Malka N; Yaffe, Yoav; Tzabari, Yuval; Namir, Daniel; Kheifets, Leeka

2015-01-30

This study characterizes extremely low frequency (ELF) magnetic field (MF) levels in 10 car models. Extensive measurements were conducted in three diesel, four gasoline, and three hybrid cars, under similar controlled conditions and negligible background fields. Averaged over all four seats under various driving scenarios the fields were lowest in diesel cars (0.02 μT), higher for gasoline (0.04-0.05 μT) and highest in hybrids (0.06-0.09 μT), but all were in-line with daily exposures from other sources. Hybrid cars had the highest mean and 95th percentile MF levels, and an especially large percentage of measurements above 0.2 μT. These parameters were also higher for moving conditions compared to standing while idling or revving at 2500 RPM and higher still at 80 km/h compared to 40 km/h. Fields in non-hybrid cars were higher at the front seats, while in hybrid cars they were higher at the back seats, particularly the back right seat where 16%-69% of measurements were greater than 0.2 μT. As our results do not include low frequency fields (below 30 Hz) that might be generated by tire rotation, we suggest that net currents flowing through the cars' metallic chassis may be a possible source of MF. Larger surveys in standardized and well-described settings should be conducted with different types of vehicles and with spectral analysis of fields including lower frequencies due to magnetization of tires.

Imaging interactions of metal oxide nanoparticles with macrophage cells by ultra-high resolution scanning electron microscopy techniques.

PubMed

Plascencia-Villa, Germán; Starr, Clarise R; Armstrong, Linda S; Ponce, Arturo; José-Yacamán, Miguel

2012-11-01

Use of engineered metal oxide nanoparticles in a plethora of biological applications and custom products has warned about some possible dose-dependent cytotoxic effects. Macrophages are key components of the innate immune system used to study possible toxic effects and internalization of different nanoparticulate materials. In this work, ultra-high resolution field emission scanning electron microscopy (FE-SEM) was used to offer new insights into the dynamical processes of interaction of nanomaterials with macrophage cells dosed with different concentrations of metal oxide nanoparticles (CeO(2), TiO(2) and ZnO). The versatility of FE-SEM has allowed obtaining a detailed characterization of processes of adsorption and endocytosis of nanoparticles, by using advanced analytical and imaging techniques on complete unstained uncoated cells, including secondary electron imaging, high-sensitive backscattered electron imaging, X-ray microanalysis and stereoimaging. Low voltage BF/DF-STEM confirmed nanoparticle adsorption and internalization into endosomes of CeO(2) and TiO(2), whereas ZnO develop apoptosis after 24 h of interaction caused by dissolution and invasion of cell nucleus. Ultra-high resolution scanning electron microscopy techniques provided new insights into interactions of inorganic nanoparticles with macrophage cells with high spatial resolution.

Imaging interactions of metal oxide nanoparticles with macrophage cells by ultra-high resolution scanning electron microscopy techniques†

PubMed Central

Plascencia-Villa, Germán; Starr, Clarise R.; Armstrong, Linda S.; Ponce, Arturo

2016-01-01

Use of engineered metal oxide nanoparticles in a plethora of biological applications and custom products has warned about some possible dose-dependent cytotoxic effects. Macrophages are key components of the innate immune system used to study possible toxic effects and internalization of different nanoparticulate materials. In this work, ultra-high resolution field emission scanning electron microscopy (FE-SEM) was used to offer new insights into the dynamical processes of interaction of nanomaterials with macrophage cells dosed with different concentrations of metal oxide nanoparticles (CeO2, TiO2 and ZnO). The versatility of FE-SEM has allowed obtaining a detailed characterization of processes of adsorption and endocytosis of nanoparticles, by using advanced analytical and imaging techniques on complete unstained uncoated cells, including secondary electron imaging, high-sensitive backscattered electron imaging, X-ray microanalysis and stereoimaging. Low voltage BF/DF-STEM confirmed nanoparticle adsorption and internalization into endosomes of CeO2 and TiO2, whereas ZnO develop apoptosis after 24 h of interaction caused by dissolution and invasion of cell nucleus. Ultra-high resolution scanning electron microscopy techniques provided new insights into interactions of inorganic nanoparticles with macrophage cells with high spatial resolution. PMID:23023106

Boron arsenide phonon dispersion from inelastic x-ray scattering: Potential for ultrahigh thermal conductivity

NASA Astrophysics Data System (ADS)

Ma, Hao; Li, Chen; Tang, Shixiong; Yan, Jiaqiang; Alatas, Ahmet; Lindsay, Lucas; Sales, Brian C.; Tian, Zhiting

2016-12-01

Cubic boron arsenide (BAs) was predicted to have an exceptionally high thermal conductivity (k ) ˜2000 W m-1K-1 at room temperature, comparable to that of diamond, based on first-principles calculations. Subsequent experimental measurements, however, only obtained a k of ˜200 W m-1K-1 . To gain insight into this discrepancy, we measured phonon dispersion of single-crystal BAs along high symmetry directions using inelastic x-ray scattering and compared these with first-principles calculations. Based on the measured phonon dispersion, we have validated the theoretical prediction of a large frequency gap between acoustic and optical modes and bunching of acoustic branches, which were considered the main reasons for the predicted ultrahigh k . This supports its potential to be a super thermal conductor if very-high-quality single-crystal samples can be synthesized.

Boron arsenide phonon dispersion from inelastic x-ray scattering: Potential for ultrahigh thermal conductivity

DOE PAGES

Ma, Hao; Li, Chen; Tang, Shixiong; ...

2016-12-14

Cubic boron arsenide (BAs) was predicted to have an exceptionally high thermal conductivity (k) ~2000 Wm -1K -1 at room temperature, comparable to that of diamond, based on first-principles calculations. Subsequent experimental measurements, however, only obtained a k of ~200 Wm-1K-1. To gain insight into this discrepancy, we measured phonon dispersion of single crystal BAs along high symmetry directions using inelastic x-ray scattering (IXS) and compared these with first-principles calculations. Based on the measured phonon dispersion, we have validated the theoretical prediction of a large frequency gap between acoustic and optical modes and bunching of acoustic branches, which were consideredmore » the main reasons for the predicted ultrahigh k. This supports its potential to be a super thermal conductor if very high-quality single crystal samples can be synthesized.« less

Hadron diffractive production at ultrahigh energies and shadow effects

NASA Astrophysics Data System (ADS)

Anisovich, V. V.; Matveev, M. A.; Nikonov, V. A.

2016-10-01

Shadow effects at collisions of hadrons with light nuclei at high energies were subject of scientific interest of V.N. Gribov, first, we mean his study of the hadron-deuteron scattering, see Sov. Phys. JETP 29, 483 (1969) [Zh. Eksp. Teor. Fiz. 56, 892 (1969)] and discovery of the reinforcement of shadowing due to inelastic diffractive rescatterings. It turns out that the similar effect exists on hadron level though at ultrahigh energies. Diffractive production is considered in the ultrahigh energy region where pomeron exchange amplitudes are transformed into black disk ones due to rescattering corrections. The corresponding corrections in hadron reactions h1 + h3 → h1 + h2 + h3 with small momenta transferred (q1→12 ˜ m2/ln2s, q3→32 ˜ m2/ln2s) are calculated in terms of the K-matrix technique modified for ultrahigh energies. Small values of the momenta transferred are crucial for introducing equations for amplitudes. The three-body equation for hadron diffractive production reaction h1 + h3 → h1 + h2 + h3 is written and solved precisely in the eikonal approach. In the black disk regime final state scattering processes do not change the shapes of amplitudes principally but dump amplitudes by a factor ˜ 1 4; initial state rescatterings result in additional factor ˜ 1 2. In the resonant disk regime initial and final state scatterings damp strongly the production amplitude that corresponds to σinel/σtot → 0 at s →∞ in this mode.

Hadron Diffractive Production at Ultrahigh Energies and Shadow Effects

NASA Astrophysics Data System (ADS)

Anisovich, V. V.; Matveev, M. A.; Nikonov, V. A.

Shadow effects at collisions of hadrons with light nuclei at high energies were subject of scientific interest of V.N. Gribov, first, we mean his study of the hadron-deuteron scattering, see Sov. Phys. JETP 29, 483 (1969) [Zh. Eksp. Teor. Fiz. 56, 892 (1969)] and discovery of the reinforcement of shadowing due to inelastic diffractive rescatterings. It turns out that the similar effect exists on hadron level though at ultrahigh energies... Diffractive production is considered in the ultrahigh energy region where pomeron exchange amplitudes are transformed into black disk ones due to rescattering corrections. The corresponding corrections in hadron reactions h1 + h3 → h1 + h2 + h3 with small momenta transferred (q^2_{1 to 1} m^2/ ln^2 s, q^2_{3 to 3} m^2/ ln^2 s) are calculated in terms of the K-matrix technique modified for ultrahigh energies. Small values of the momenta transferred are crucial for introducing equations for amplitudes. The three-body equation for hadron diffractive production reaction h1 + h3 → h1 + h2 + h3 is written and solved precisely in the eikonal approach. In the black disk regime final state scattering processes do not change the shapes of amplitudes principally but dump amplitudes by a factor 1/4 initial state rescatterings result in additional factor 1/2. In the resonant disk regime initial and final state scatterings damp strongly the production amplitude that corresponds to σ_{inel}/σ_{tot} to 0 at √{s}to ∞ in this mode.

Examining the association between social cognition and functioning in individuals at ultra-high risk for psychosis.

PubMed

Cotter, Jack; Bartholomeusz, Cali; Papas, Alicia; Allott, Kelly; Nelson, Barnaby; Yung, Alison R; Thompson, Andrew

2017-01-01

Social and role functioning are compromised for the majority of individuals at ultra-high risk of psychosis, and it is important to identify factors that contribute to this functional decline. This study aimed to investigate social cognitive abilities, which have previously been linked to functioning in schizophrenia, as potential factors that impact social, role and global functioning in ultra-high risk patients. A total of 30 ultra-high risk patients were recruited from an established at-risk clinical service in Melbourne, Australia, and completed a battery of social cognitive, neurocognitive, clinical and functioning measures. We examined the relationships between all four core domains of social cognition (emotion recognition, theory of mind, social perception and attributional style), neurocognitive, clinical and demographic variables with three measures of functioning (the Global Functioning Social and Role scales and the Social and Occupational Functioning Assessment Scale) using correlational and multiple regression analyses. Performance on a visual theory of mind task (visual jokes task) was significantly correlated with both concurrent role ( r = 0.425, p = 0.019) and global functioning ( r = 0.540, p = 0.002). In multivariate analyses, it also accounted for unique variance in global, but not role functioning after adjusting for negative symptoms and stress. Social functioning was not associated with performance on any of the social cognition tasks. Among specific social cognitive abilities, only a test of theory of mind was associated with functioning in our ultra-high risk sample. Further longitudinal research is needed to examine the impact of social cognitive deficits on long-term functional outcome in the ultra-high risk group. Identifying social cognitive abilities that significantly impact functioning is important to inform the development of targeted intervention programmes for ultra-high risk individuals.

Ultrahigh vacuum process for the deposition of nanotubes and nanowires

DOEpatents

Das, Biswajit; Lee, Myung B

2015-02-03

A system and method A method of growing an elongate nanoelement from a growth surface includes: a) cleaning a growth surface on a base element; b) providing an ultrahigh vacuum reaction environment over the cleaned growth surface; c) generating a reactive gas of an atomic material to be used in forming the nanoelement; d) projecting a stream of the reactive gas at the growth surface within the reactive environment while maintaining a vacuum of at most 1.times.10.sup.-4 Pascal; e) growing the elongate nanoelement from the growth surface within the environment while maintaining the pressure of step c); f) after a desired length of nanoelement is attained within the environment, stopping direction of reactive gas into the environment; and g) returning the environment to an ultrahigh vacuum condition.

A continuously weighing, high frequency sand trap: Wind tunnel and field evaluations

NASA Astrophysics Data System (ADS)

Yang, Fan; Yang, XingHua; Huo, Wen; Ali, Mamtimin; Zheng, XinQian; Zhou, ChengLong; He, Qing

2017-09-01

A new continuously weighing, high frequency sand trap (CWHF) has been designed. Its sampling efficiency is evaluated in a wind tunnel and the potential of the new trap has been demonstrated in field trials. The newly designed sand trap allows fully automated and high frequency measurement of sediment fluxes over extensive periods. We show that it can capture the variations and structures of wind-driven sand transport processes and horizontal sediment flux, and reveal the relationships between sand transport and meteorological parameters. Its maximum sampling frequency can reach 10 Hz. Wind tunnel tests indicated that the sampling efficiency of the CWHF sand trap varies between 39.2 to 64.3%, with an average of 52.5%. It achieved a maximum sampling efficiency of 64.3% at a wind speed of 10 m s- 1. This is largely achieved by the inclusion of a vent hole which leads to a higher sampling efficiency than that of a step-like sand trap at high wind speeds. In field experiments, we show a good agreement between the mass of sediment from the CWHF sand trap, the wind speed at 2 m and the number of saltating particles at 5 cm above the ground surface. According to analysis of the horizontal sediment flux at four heights from the CWHF sand trap (25, 35, 50, and 100 cm), the vertical distribution of the horizontal sediment flux up to a height of 100 cm above the sand surface follows an exponential function. Our field experiments show that the new instrument can capture more detailed information on sediment transport with much reduced labor requirement. Therefore, it has great potential for application in wind-blown sand monitoring and process studies.

Ultrahigh vacuum focused ion beam micromill and articles therefrom

DOEpatents

Lamartine, Bruce C.; Stutz, Roger A.

1998-01-01

An ultrahigh vacuum focused ion beam micromilling apparatus and process are isclosed. Additionally, a durable data storage medium using the micromilling process is disclosed, the durable data storage medium capable of storing, e.g., digital or alphanumeric characters as well as graphical shapes or characters.

Bond Behavior of Reinforcing Steel in Ultra-High Performance Concrete

DOT National Transportation Integrated Search

2014-11-01

Ultra-high performance concrete (UHPC) has garnered interest from the highway infrastructure community for its greatly enhanced mechanical and durability properties. The objective of this research is to extensively evaluate the factors that affect bo...

T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 μm.

PubMed

Lüsebrink, Falk; Sciarra, Alessandro; Mattern, Hendrik; Yakupov, Renat; Speck, Oliver

2017-03-14

We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T 1 -weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 μm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximately 1.2 TB and was acquired in eight hours total scan time. The resolution of this dataset is far beyond any previously published in vivo structural whole brain dataset. Its potential use is to build an in vivo MR brain atlas. Methods for image reconstruction and image restoration can be improved as the raw data is made available. Pre-processing and segmentation procedures can possibly be enhanced for high magnetic field strength and ultrahigh resolution data. Furthermore, potential resolution induced changes in quantitative data analysis can be assessed, e.g., cortical thickness or volumetric measures, as high quality images with an isotropic resolution of 1 and 0.5 mm of the same subject are included in the repository as well.

T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 μm

NASA Astrophysics Data System (ADS)

Lüsebrink, Falk; Sciarra, Alessandro; Mattern, Hendrik; Yakupov, Renat; Speck, Oliver

2017-03-01

We present an ultrahigh resolution in vivo human brain magnetic resonance imaging (MRI) dataset. It consists of T1-weighted whole brain anatomical data acquired at 7 Tesla with a nominal isotropic resolution of 250 μm of a single young healthy Caucasian subject and was recorded using prospective motion correction. The raw data amounts to approximately 1.2 TB and was acquired in eight hours total scan time. The resolution of this dataset is far beyond any previously published in vivo structural whole brain dataset. Its potential use is to build an in vivo MR brain atlas. Methods for image reconstruction and image restoration can be improved as the raw data is made available. Pre-processing and segmentation procedures can possibly be enhanced for high magnetic field strength and ultrahigh resolution data. Furthermore, potential resolution induced changes in quantitative data analysis can be assessed, e.g., cortical thickness or volumetric measures, as high quality images with an isotropic resolution of 1 and 0.5 mm of the same subject are included in the repository as well.

Effects of the plasma profiles on photon and pair production in ultrahigh intensity laser solid interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tian, Y. X.; Jin, X. L., E-mail: jinxiaolin@uestc.edu.cn; Yan, W. Z.

The model of photon and pair production in strong field quantum electrodynamics is implemented into our 1D3V particle-in-cell code with Monte Carlo algorithm. Using this code, the evolution of the particles in ultrahigh intensity laser (∼10{sup 23} W/cm{sup 2}) interaction with aluminum foil target is observed. Four different initial plasma profiles are considered in the simulations. The effects of initial plasma profiles on photon and pair production, energy spectra, and energy evolution are analyzed. The results imply that one can set an optimal initial plasma profile to obtain the desired photon distributions.

EQUALIZING THE ELECTRIC FIELD INTENSITY WITHIN CHICK BRAIN IMMERSED IN BUFFER SOLUTION AT DIFFERENT CARRIER FREQUENCIES

EPA Science Inventory

Presented here are the numerical relationships between incident power densities that produce the same average electric field intensity within a chick brain half immersed in buffered saline solution and exposed to a uniform electromagnetic field at carrier frequencies of 50, 147, ...

[The influence of application of a low-frequency magnetic field on the serum corticosterone level (an experimental study)].

PubMed

Alabovskiĭ, V V; Gotovskiĭ, M Iu; Vinokurov, A A; Maslov, O V

2013-01-01

The results of analysis of the literature publications suggest the necessity of experimental studies aimed at investigation of modulating effect of low-frequency magnetic fields on endocrine organs. The present study was carried out using 200 outbred white male rats (body weight 200-220 g). Corticosterone was measured in blood sera following the application of a low-frequency magnetic field (20 and 53 Hz with induction from 0.4 to 6 mT) generated by a Mini-Expert-T apparatus for induction magnetic therapy during 30 minutes. It was shown that the application of the alternating magnetic field to the adrenal region of the rats in the selected frequency and induction ranges caused a significant increase in the serum corticosterone levels. The results of the present study on the hormonal activity of rat adrenals give reason to consider the influence of the alternating magnetic fields as being modulatory. Analysis of the data thus obtained has demonstrated the non-linear dependence of glucocorticoid activity of the rat adrenal glands on the induction strength of the alternating magnetic field.

Experimental observation of the inductive electric field and related plasma nonuniformity in high frequency capacitive discharge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahn, S. K.; Chang, H. Y.

To elucidate plasma nonuniformity in high frequency capacitive discharges, Langmuir probe and B-dot probe measurements were carried out in the radial direction in a cylindrical capacitive discharge driven at 90 MHz with argon pressures of 50 and 400 mTorr. Through the measurements, a significant inductive electric field (i.e., time-varying magnetic field) was observed at the radial edge, and it was found that the inductive electric field creates strong plasma nonuniformity at high pressure operation. The plasma nonuniformity at high pressure operation is physically similar to the E-H mode transition typically observed in inductive discharges. This result agrees well with themore » theories of electromagnetic effects in large area and/or high frequency capacitive discharges.« less

Development of Non-Proprietary Ultra-High Performance Concrete : Final Report

DOT National Transportation Integrated Search

2017-12-01

Ultra-high performance concrete (UHPC) has mechanical and durability properties that far exceed those of conventional concrete. Particularly, UHPC has compressive and post-cracking tensile strengths of around 20 ksi and 0.72 ksi, respectively. Thus, ...

Ultrahigh sensitivity endoscopic camera using a new CMOS image sensor: providing with clear images under low illumination in addition to fluorescent images.

PubMed

Aoki, Hisae; Yamashita, Hiromasa; Mori, Toshiyuki; Fukuyo, Tsuneo; Chiba, Toshio

2014-11-01

We developed a new ultrahigh-sensitive CMOS camera using a specific sensor that has a wide range of spectral sensitivity characteristics. The objective of this study is to present our updated endoscopic technology that has successfully integrated two innovative functions; ultrasensitive imaging as well as advanced fluorescent viewing. Two different experiments were conducted. One was carried out to evaluate the function of the ultrahigh-sensitive camera. The other was to test the availability of the newly developed sensor and its performance as a fluorescence endoscope. In both studies, the distance from the endoscopic tip to the target was varied and those endoscopic images in each setting were taken for further comparison. In the first experiment, the 3-CCD camera failed to display the clear images under low illumination, and the target was hardly seen. In contrast, the CMOS camera was able to display the targets regardless of the camera-target distance under low illumination. Under high illumination, imaging quality given by both cameras was quite alike. In the second experiment as a fluorescence endoscope, the CMOS camera was capable of clearly showing the fluorescent-activated organs. The ultrahigh sensitivity CMOS HD endoscopic camera is expected to provide us with clear images under low illumination in addition to the fluorescent images under high illumination in the field of laparoscopic surgery.

A new method for gravity field recovery based on frequency analysis of spherical harmonics

NASA Astrophysics Data System (ADS)

Cai, Lin; Zhou, Zebing

2017-04-01

All existing methods for gravity field recovery are mostly based on the space-wise and time-wise approach, whose core processes are constructing the observation equations and solving them by the least square method. It's should be pointed that the least square method means the approximation. On the other hand, we can directly and precisely obtain the coefficients of harmonics by computing the Fast Fourier Transform (FFT) when we do 1-D data (time series) analysis. So the question whether we directly and precisely obtain the coefficients of spherical harmonic by computing 2-D FFT of measurements of satellite gravity mission is of great significance, since this may guide us to a new understanding of the signal components of gravity field and make us determine it quickly by taking advantage of FFT. Like the 1-D data analysis, the 2-D FFT of measurements of satellite can be computed rapidly. If we can determine the relationship between spherical harmonics and 2-D Fourier frequencies and the transfer function from measurements to spherical coefficients, the question mentioned above can be solved. So the objective of this research project is to establish a new method based on frequency analysis of spherical harmonic, which directly compute the confidents of spherical harmonic of gravity field, which is differ from recovery by least squares. There is a one to one correspondence between frequency spectrum and the time series in 1-D FFT. The 2-D FFT has a similar relationship to 1-D FFT. Owing to the fact that any degree or order (higher than one) of spherical function has multi frequencies and these frequencies may be aliased. Fortunately, the elements and ratio of these frequencies of spherical function can be determined, and we can compute the coefficients of spherical function from 2-D FFT. This relationship can be written as equations and equivalent to a matrix, which is solid and can be derived in advance. Until now the relationship has be determined. Some preliminary

Extremely low-frequency magnetic fields can impair spermatogenesis recovery after reversible testicular damage induced by heat.

PubMed

Tenorio, Bruno Mendes; Ferreira Filho, Moisés Bonifacio Alves; Jimenez, George Chaves; de Morais, Rosana Nogueira; Peixoto, Christina Alves; Nogueira, Romildo de Albuquerque; da Silva Junior, Valdemiro Amaro

2014-06-01

Male infertility is often related to reproductive age couples experiencing fertility-related issues. Men may have fertility problems associated with reversible testicular damage. Considering that men have been increasingly exposed to extremely low-frequency magnetic fields generated by the production, distribution and use of electricity, this study analyzed whether 60 Hz and 1 mT magnetic field exposure may impair spermatogenesis recovery after reversible testicular damage induced by heat shock using rats as an experimental model. Adult male rats were subjected to a single testicular heat shock (HS, 43 °C for 12 min) and then exposed to the magnetic field for 15, 30 and 60 d after HS. Magnetic field exposure during the spermatogenesis recovery induced changes in testis components volume, cell ultrastructure and histomorphometrical parameters. Control animals had a reestablished and active spermatogenesis at 60 d after heat shock, while animals exposed to magnetic field still showed extensive testicular degeneration. Magnetic field exposure did not change the plasma testosterone. In conclusion, extremely low-frequency magnetic field may be harmful to fertility recovery in males affected by reversible testicular damage.

Ultrahigh vacuum focused ion beam micromill and articles therefrom

DOEpatents

Lamartine, B.C.; Stutz, R.A.

1998-02-24

An ultrahigh vacuum focused ion beam micromilling apparatus and process are disclosed. Additionally, a durable data storage medium using the micromilling process is disclosed, the durable data storage medium capable of storing, e.g., digital or alphanumeric characters as well as graphical shapes or characters. 6 figs.

Radio Frequency (RF) Trap for Confinement of Antimatter Plasmas Using Rotating Wall Electric Fields

NASA Technical Reports Server (NTRS)

Sims, William Herbert, III; Pearson, J. Boise

2004-01-01

Perturbations associated with a rotating wall electric field enable the confinement of ions for periods approaching weeks. This steady state confinement is a result of a radio frequency manipulation of the ions. Using state-of-the-art techniques it is shown that radio frequency energy can produce useable manipulation of the ion cloud (matter or antimatter) for use in containment experiments. The current research focuses on the improvement of confinement systems capable of containing and transporting antimatter.

In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI

PubMed Central

Mainero, C; Benner, T; Radding, A; van der Kouwe, A; Jensen, R; Rosen, B R.; Kinkel, R P.

2009-01-01

Objective: We used ultra-high field MRI to visualize cortical lesion types described by neuropathology in 16 patients with multiple sclerosis (MS) compared with 8 age-matched controls; to characterize the contrast properties of cortical lesions including T2*, T2, T1, and phase images; and to investigate the relationship between cortical lesion types and clinical data. Methods: We collected, on a 7-T scanner, 2-dimensional fast low-angle shot (FLASH)-T2*-weighted spoiled gradient-echo, T2-weighted turbo spin-echo (TSE) images (0.33 × 033 × 1 mm3), and a 3-dimensional magnetization-prepared rapid gradient echo. Results: Overall, 199 cortical lesions were detected in patients on both FLASH-T2* and T2-TSE scans. Seven-tesla MRI allowed for characterization of cortical plaques into type I (leukocortical), type II (intracortical), and type III/IV (subpial extending partly or completely through the cortical width) lesions as described histopathologically. Types III and IV were the most frequent type of cortical plaques (50.2%), followed by type I (36.2%) and type II (13.6%) lesions. Each lesion type was more frequent in secondary progressive than in relapsing–remitting MS. This difference, however, was significant only for type III/IV lesions. T2*-weighted images showed the highest, while phase images showed the lowest, contrast-to-noise ratio for all cortical lesion types. In patients, the number of type III/IV lesions was associated with greater disability (p < 0.02 by Spearman test) and older age (p < 0.04 by Spearman test). Conclusions: Seven-tesla MRI detected different histologic cortical lesion types in our small multiple sclerosis (MS) sample, suggesting, if validated in a larger population, that it may prove a valuable tool to assess the contribution of cortical MS pathology to clinical disability. GLOSSARY ANOVA = analysis of variance; BN = background noise; CNR = contrast-to-noise ratio; DIR = double-inversion recovery; EDSS = Expanded Disability Status

Stereo Sound Field Controller Design Using Partial Model Matching on the Frequency Domain

NASA Astrophysics Data System (ADS)

Kumon, Makoto; Miike, Katsuhiro; Eguchi, Kazuki; Mizumoto, Ikuro; Iwai, Zenta

The objective of sound field control is to make the acoustic characteristics of a listening room close to those of the desired system. Conventional methods apply feedforward controllers, such as digital filters, to achieve this objective. However, feedback controllers are also necessary in order to attenuate noise or to compensate the uncertainty of the acoustic characteristics of the listening room. Since acoustic characteristics are well modeled on the frequency domain, it is efficient to design controllers with respect to frequency responses, but it is difficult to design a multi input multi output (MIMO) control system on a wide frequency domain. In the present study, a partial model matching method on the frequency domain was adopted because this method requires only sampled data, rather than complex mathematical models of the plant, in order to design controllers for MIMO systems. The partial model matching method was applied to design two-degree-of-freedom controllers for acoustic equalization and noise reduction. Experiments demonstrated effectiveness of the proposed method.

Manganese oxide micro-supercapacitors with ultra-high areal capacitance

NASA Astrophysics Data System (ADS)

Wang, Xu; Myers, Benjamin D.; Yan, Jian; Shekhawat, Gajendra; Dravid, Vinayak; Lee, Pooi See

2013-05-01

A symmetric micro-supercapacitor is constructed by electrochemically depositing manganese oxide onto micro-patterned current collectors. High surface-to-volume ratio of manganese oxide and short diffusion distance between electrodes give an ultra-high areal capacitance of 56.3 mF cm-2 at a current density of 27.2 μA cm-2.A symmetric micro-supercapacitor is constructed by electrochemically depositing manganese oxide onto micro-patterned current collectors. High surface-to-volume ratio of manganese oxide and short diffusion distance between electrodes give an ultra-high areal capacitance of 56.3 mF cm-2 at a current density of 27.2 μA cm-2. Electronic supplementary information (ESI) available: Experimental procedures; optical images of micro-supercapacitors; areal capacitances of samples M-0.3C, M-0.6C and M-0.9C; illustration of interdigital finger electrodes; Nyquist plot of Co(OH)2 deposited on micro-electrodes. See DOI: 10.1039/c3nr00210a

Study of extremely low frequency electromagnetic fields in infant incubators.

PubMed

Cermáková, Eleonora

2003-01-01

The aim of the work was to present the results of measurements of extremely low frequency electromagnetic fields (ELF EMF), namely the magnetic flux density, inside infant incubators, and to compare these results with the data published by other authors who point out to a possible association between leukemia or other diseases observed in newborns kept in incubators after the birth and the ELF EMF exposure in the incubator. The measured magnetic flux densities were compared with the reference values for this frequency range indicated in the European Union (EU) recommendations. The repeated measurements in incubators were made with a calibrated magnetometer EFA 300 in the frequency range of 5-30 kHz. Effective values of magnetic flux densities of ELF EMF were determined taking account of the reference values. The results of many repeated measurements showing the values of magnetic flux density in modern incubators with plastic supporting frame, were compared with those obtained in old type incubators with iron skeleton. A power frequency of 50 Hz was detected in the incubator and the ELF EMF values were by over two orders lower than the EU reference values. The paper emphasizes the need to take a special care of newborns kept in incubators even if only the sub-reference values are detected. The EU reference values are intended for the adult human population. A baby in an incubator has much smaller dimensions, higher electric conductivity and maybe trigger another mechanism of response to ELF EMF than that indicated in this paper.

On the frequency spectra of the core magnetic field Gauss coefficients

NASA Astrophysics Data System (ADS)

Lesur, Vincent; Wardinski, Ingo; Baerenzung, Julien; Holschneider, Matthias

2018-03-01

From monthly mean observatory data spanning 1957-2014, geomagnetic field secular variation values were calculated by annual differences. Estimates of the spherical harmonic Gauss coefficients of the core field secular variation were then derived by applying a correlation based modelling. Finally, a Fourier transform was applied to the time series of the Gauss coefficients. This process led to reliable temporal spectra of the Gauss coefficients up to spherical harmonic degree 5 or 6, and down to periods as short as 1 or 2 years depending on the coefficient. We observed that a k-2 slope, where k is the frequency, is an acceptable approximation for these spectra, with possibly an exception for the dipole field. The monthly estimates of the core field secular variation at the observatory sites also show that large and rapid variations of the latter happen. This is an indication that geomagnetic jerks are frequent phenomena and that significant secular variation signals at short time scales - i.e. less than 2 years, could still be extracted from data to reveal an unexplored part of the core dynamics.

[Influence of extremely low-frequency magnetic field on circadian rhythm of cryptochrome in mouse embryonic fibroblasts].

PubMed

Sun, Z Y; Geng, D Y; Chen, C F; Wang, P P; Song, T

2017-06-20

Objective: To investigate the influence of extremely low-frequency magnetic field on periodical expression of cryptochrome ( Cry ) gene in mouse embryonic fibroblast NIH3T3 cells. Methods: The NIH3T3 cells were divided into magnetic field group and sham-exposure group. The NIH3T3 cells in the magnetic field group were stimulated by horse serum and then exposed to an extremely low-frequency magnetic field (50 Hz and 0.3 mT) for 48 hours, and those in the sham-exposure group were also stimulated by horse serum and then exposed to a coil for 48 hours. The NIH3T3 cells were collected, total RNA was extracted, and cDNA was obtained via reverse transcription. Real-time fluorescent quantitative RT-PCR was used to measure the changes in transcription cycles of Cry and Period genes in both groups. Results: There was no significant difference in the proliferation rate at 0, 12, 24, and 48 hours of exposure between the two groups ( P >0.05) . Both sham-exposure group and magnetic field group showed a rhythmic change in the expression of Cry gene, and compared with the sham-exposure group, the magnetic field group had a significantly shortened circadian rhythm of Cry gene in NIH3T3 cells ( t =2.57, P <0.05) . Both groups had rhythmic and periodical expression of Period gene and there was no significant difference between the two groups ( t =0.70, P >0.05) . Conclusion: Extremely low-frequency magnetic field can significantly shorten the circadian rhythm of Cry gene in mouse embryonic fibroblasts, while there is no significant change in the circadian rhythm of Period gene.

Characterization of Extremely Low Frequency Magnetic Fields from Diesel, Gasoline and Hybrid Cars under Controlled Conditions

PubMed Central

Hareuveny, Ronen; Sudan, Madhuri; Halgamuge, Malka N.; Yaffe, Yoav; Tzabari, Yuval; Namir, Daniel; Kheifets, Leeka

2015-01-01

This study characterizes extremely low frequency (ELF) magnetic field (MF) levels in 10 car models. Extensive measurements were conducted in three diesel, four gasoline, and three hybrid cars, under similar controlled conditions and negligible background fields. Averaged over all four seats under various driving scenarios the fields were lowest in diesel cars (0.02 μT), higher for gasoline (0.04–0.05 μT) and highest in hybrids (0.06–0.09 μT), but all were in-line with daily exposures from other sources. Hybrid cars had the highest mean and 95th percentile MF levels, and an especially large percentage of measurements above 0.2 μT. These parameters were also higher for moving conditions compared to standing while idling or revving at 2500 RPM and higher still at 80 km/h compared to 40 km/h. Fields in non-hybrid cars were higher at the front seats, while in hybrid cars they were higher at the back seats, particularly the back right seat where 16%–69% of measurements were greater than 0.2 μT. As our results do not include low frequency fields (below 30 Hz) that might be generated by tire rotation, we suggest that net currents flowing through the cars’ metallic chassis may be a possible source of MF. Larger surveys in standardized and well-described settings should be conducted with different types of vehicles and with spectral analysis of fields including lower frequencies due to magnetization of tires. PMID:25647323

Characterization of Indoor Extremely Low Frequency and Low Frequency Electromagnetic Fields in the INMA-Granada Cohort

PubMed Central

Calvente, Irene; Dávila-Arias, Cristina; Ocón-Hernández, Olga; Pérez-Lobato, Rocío; Ramos, Rosa; Artacho-Cordón, Francisco; Olea, Nicolás; Núñez, María Isabel; Fernández, Mariana F.

2014-01-01

Objective To characterize the exposure to electric fields and magnetic fields of non-ionizing radiation in the electromagnetic spectrum (15 Hz to 100 kHz) in the dwellings of children from the Spanish Environment and Childhood-“INMA” population-based birth cohort. Methodology The study sample was drawn from the INMA-Granada cohort. Out of 300 boys participating in the 9–10 year follow-up, 123 families agreed to the exposure assessment at home and completed a specific ad hoc questionnaire gathering information on sources of non-ionizing radiation electric and magnetic fields inside the homes and on patterns of use. Long-term indoor measurements were carried out in the living room and bedroom. Results Survey data showed a low exposure in the children's homes according to reference levels of the International Commission on Non-Ionizing Radiation Protection but with large differences among homes in mean and maximum values. Daytime electrostatic and magnetic fields were below the quantification limit in 78.6% (92 dwellings) and 92.3% (108 dwellings) of houses, with an arithmetic mean value (± standard deviation) of 7.31±9.32 V/m and 162.30±91.16 nT, respectively. Mean magnetic field values were 1.6 lower during the night than the day. Nocturnal electrostatic values were not measured. Exposure levels were influenced by the area of residence (higher values in urban/semi-urban versus rural areas), type of dwelling, age of dwelling, floor of the dwelling, and season. Conclusion Given the greater sensitivity to extremely low-frequency electromagnetic fields of children and following the precautionary principle, preventive measures are warranted to reduce their exposure. PMID:25192253

Characterization of indoor extremely low frequency and low frequency electromagnetic fields in the INMA-Granada cohort.

PubMed

Calvente, Irene; Dávila-Arias, Cristina; Ocón-Hernández, Olga; Pérez-Lobato, Rocío; Ramos, Rosa; Artacho-Cordón, Francisco; Olea, Nicolás; Núñez, María Isabel; Fernández, Mariana F

2014-01-01

To characterize the exposure to electric fields and magnetic fields of non-ionizing radiation in the electromagnetic spectrum (15 Hz to 100 kHz) in the dwellings of children from the Spanish Environment and Childhood-"INMA" population-based birth cohort. The study sample was drawn from the INMA-Granada cohort. Out of 300 boys participating in the 9-10 year follow-up, 123 families agreed to the exposure assessment at home and completed a specific ad hoc questionnaire gathering information on sources of non-ionizing radiation electric and magnetic fields inside the homes and on patterns of use. Long-term indoor measurements were carried out in the living room and bedroom. Survey data showed a low exposure in the children's homes according to reference levels of the International Commission on Non-Ionizing Radiation Protection but with large differences among homes in mean and maximum values. Daytime electrostatic and magnetic fields were below the quantification limit in 78.6% (92 dwellings) and 92.3% (108 dwellings) of houses, with an arithmetic mean value (± standard deviation) of 7.31±9.32 V/m and 162.30±91.16 nT, respectively. Mean magnetic field values were 1.6 lower during the night than the day. Nocturnal electrostatic values were not measured. Exposure levels were influenced by the area of residence (higher values in urban/semi-urban versus rural areas), type of dwelling, age of dwelling, floor of the dwelling, and season. Given the greater sensitivity to extremely low-frequency electromagnetic fields of children and following the precautionary principle, preventive measures are warranted to reduce their exposure.

Frequency-tuning radiofrequency plasma source operated in inductively-coupled mode under a low magnetic field

NASA Astrophysics Data System (ADS)

Takahashi, Kazunori; Nakano, Yudai; Ando, Akira

2017-07-01

A radiofrequency (rf) inductively-coupled plasma source is operated with a frequency-tuning impedance matching system, where the rf frequency is variable in the range of 20-50 MHz and the maximum power is 100 W. The source consists of a 45 mm-diameter pyrex glass tube wound by an rf antenna and a solenoid providing a magnetic field strength in the range of 0-200 Gauss. A reflected rf power for no plasma case is minimized at the frequency of ˜25 MHz, whereas the frequency giving the minimum reflection with the high density plasma is about 28 MHz, where the density jump is observed when minimizing the reflection. A high density argon plasma above 1× {{10}12} cm-3 is successfully obtained in the source for the rf power of 50-100 W, where it is observed that an external magnetic field of a few tens of Gauss yields the highest plasma density in the present configuration. The frequency-tuning plasma source is applied to a compact and high-speed silicon etcher in an Ar-SF6 plasma; then the etching rate of 8~μ m min-1 is obtained for no bias voltage to the silicon wafer, i.e. for the case that a physical ion etching process is eliminated.

Regulation of cellular function via electromagnetic field frequency and extracellular environment: A theoretical- experimental approach

NASA Astrophysics Data System (ADS)

Taghian, Toloo; Sheikh, Abdul; Narmoneva, Daria; Kogan, Andrei

2015-03-01

Application of external electric field (EF) as a non-pharmacological, non-invasive tool to control cell function is of great therapeutic interest. We developed a theoretical-experimental approach to investigate the biophysical mechanisms of EF interaction with cells in electrode-free physiologically-relevant configuration. Our numerical results demonstrated that EF frequency is the major parameter to control cell response to EF. Non-oscillating or low-frequency EF leads to charge accumulation on the cell surface membrane that may mediate membrane initiated cell responses. In contrast, high-frequency EF penetrates the cell membrane and reaches cell cytoplasm, where it may directly activate intracellular responses. The theoretical predictions were confirmed in our experimental studies of the effects of applied EF on vascular cell function. Results show that non-oscillating EF increases vascular endothelial growth factor (VEGF) expression while field polarity controls cell adhesion rate. High-frequency, but not low frequency, EF provides differential regulation of cytoplasmic focal adhesion kinase and VEGF expression depending on the substrate, with increased expression in cells cultured on RGD-rich synthetic hydrogels, and decreased expression for matrigel culture. The authors acknowledge the financial support from the NSF (DMR-1206784 & DMR-0804199 to AK); the NIH (1R21 DK078814-01A1 to DN) and the University of Cincinnati (Interdisciplinary Faculty Research Support Grant to DN and AK).

Ultrahigh Ductility, High-Carbon Martensitic Steel

NASA Astrophysics Data System (ADS)

Qin, Shengwei; Liu, Yu; Hao, Qingguo; Zuo, Xunwei; Rong, Yonghua; Chen, Nailu

2016-10-01

Based on the proposed design idea of the anti-transformation-induced plasticity effect, both the additions of the Nb element and pretreatment of the normalization process as a novel quenching-partitioning-tempering (Q-P-T) were designed for Fe-0.63C-1.52Mn-1.49Si-0.62Cr-0.036Nb hot-rolled steel. This high-carbon Q-P-T martensitic steel exhibits a tensile strength of 1890 MPa and elongation of 29 pct accompanied by the excellent product of tensile and elongation of 55 GPa pct. The origin of ultrahigh ductility for high-carbon Q-P-T martensitic steel is revealed from two aspects: one is the softening of martensitic matrix due to both the depletion of carbon in the matensitic matrix during the Q-P-T process by partitioning of carbon from supersaturated martensite to retained austenite and the reduction of the dislocation density in a martensitic matrix by dislocation absorption by retained austenite effect during deformation, which significantly enhances the deformation ability of martensitic matrix; another is the high mechanical stability of considerable carbon-enriched retained austenite, which effectively reduces the formation of brittle twin-type martensite. This work verifies the correctness of the design idea of the anti-TRIP effect and makes the third-generation advanced high-strength steels extend to the field of high-carbon steels from low- and medium-carbon steels.

Experimental determination of the frequency and field dependence of Specific Loss Power in Magnetic Fluid Hyperthermia

NASA Astrophysics Data System (ADS)

Cobianchi, M.; Guerrini, A.; Avolio, M.; Innocenti, C.; Corti, M.; Arosio, P.; Orsini, F.; Sangregorio, C.; Lascialfari, A.

2017-12-01

Magnetic nanoparticles are promising systems for biomedical applications and in particular for Magnetic Fluid Hyperthermia, a therapy that utilizes the heat released by such systems to damage tumor cells. We present an experimental study of the physical properties that influences the capability of heat release, i.e. the Specific Loss Power, SLP, of three biocompatible ferrofluid samples having a magnetic core of maghemite with different diameter d = 10.2, 14.6 and 19.7 nm. The SLP was measured as a function of frequency f and intensity H of the applied alternating magnetic field, and it turned out to depend on the core diameter, as expected. The results allowed us to highlight experimentally that the physical mechanism responsible for the heating is size-dependent and to establish, at applied constant frequency, the phenomenological functional relationship SLP = c·Hx, with 2 ≤ x<3 for all samples. The x-value depends on sample size and field frequency, here chosen in the typical range of operating magnetic hyperthermia devices. For the smallest sample, the effective relaxation time τeff ≈ 19.5 ns obtained from SLP data is in agreement with the value estimated from magnetization data, thus confirming the validity of the Linear Response Theory model for this system at properly chosen field intensity and frequency.

Bond behavior of reinforcing steel in ultra-high performance concrete.

DOT National Transportation Integrated Search

2014-10-01

Ultra-High Performance Concrete (UHPC) is a relatively new class of advanced cementitious composite : materials, which exhibits high compressive [above 21.7 ksi (150 MPa)] and tensile [above 0.72 ksi (5 MPa)] : strengths. The discrete steel fiber rei...

Ultra-high speed vacuum pump system with first stage turbofan and second stage turbomolecular pump

DOEpatents

Jostlein, Hans

2006-04-04

An ultra-high speed vacuum pump evacuation system includes a first stage ultra-high speed turbofan and a second stage conventional turbomolecular pump. The turbofan is either connected in series to a chamber to be evacuated, or is optionally disposed entirely within the chamber. The turbofan employs large diameter rotor blades operating at high linear blade velocity to impart an ultra-high pumping speed to a fluid. The second stage turbomolecular pump is fluidly connected downstream from the first stage turbofan. In operation, the first stage turbofan operates in a pre-existing vacuum, with the fluid asserting only small axial forces upon the rotor blades. The turbofan imparts a velocity to fluid particles towards an outlet at a high volume rate, but moderate compression ratio. The second stage conventional turbomolecular pump then compresses the fluid to pressures for evacuation by a roughing pump.

Salt Neutrino Detector for Ultrahigh-Energy Neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiba, M.; Yasuda, O.; Kamijo, T.

2004-11-01

Rock salt and limestone are studied to determine their suitability for use as a radio-wave transmission medium in an ultrahigh energy (UHE) cosmic neutrino detector. A sensible radio wave would be emitted by the coherent Cherenkov radiation from negative excess charges inside an electromagnetic shower upon interaction of a UHE neutrino in a high-density medium (Askar'yan effect). If the attenuation length for the radio wave in the material is large, a relatively small number of radio-wave sensors could detect the interaction occurring in the massive material. We measured the complex permittivity of the rock salt and limestone by the perturbedmore » cavity resonator method at 9.4 and 1 GHz to good precision. We obtained new results of measurements at the frequency at 1.0 GHz. The measured value of the radio-wave attenuation length of synthetic rock salt samples is 1080 m. The samples from the Hockley salt mine in the United States show attenuation length of 180 m at 1 GHz, and then we estimate it by extrapolation to be as long as 900 m at 200 MHz. The results show that there is a possibility of utilizing natural massive deposits of rock salt for a UHE neutrino detector. A salt neutrino detector with a size of 2 x 2 x 2 km would detect 10 UHE neutrino/yr generated through the GZK process.« less

Radio frequency self-resonant coil for contactless AC-conductivity in 100 T class ultra-strong pulse magnetic fields

NASA Astrophysics Data System (ADS)

Nakamura, D.; Altarawneh, M. M.; Takeyama, S.

2018-03-01

A contactless measurement system of electrical conductivity was developed for application under pulsed high magnetic fields over 100 T by using a self-resonant-type, high-frequency circuit. Electromagnetic fields in the circuit were numerically analysed by the finite element method, to show how the resonant power spectra of the circuit depends on the electrical conductivity of a sample set on the probe-coil. The performance was examined using a high-temperature cuprate superconductor, La2-x Sr x CuO4, in magnetic fields up to 102 T with a high frequency of close to 800 MHz. As a result, the upper critical field could be determined with a good signal-to-noise ratio.

High-speed and ultrahigh-speed cinematographic recording techniques

NASA Astrophysics Data System (ADS)

Miquel, J. C.

1980-12-01

A survey is presented of various high-speed and ultrahigh-speed cinematographic recording systems (covering a range of speeds from 100 to 14-million pps). Attention is given to the functional and operational characteristics of cameras and to details of high-speed cinematography techniques (including image processing, and illumination). A list of cameras (many of them French) available in 1980 is presented

The Role of Ultrahigh Resolution Fourier Transform Mass Spectrometry (FT-MS) in Astrobiology-Related Research: Analysis of Meteorites and Tholins.

PubMed

Somogyi, Árpád; Thissen, Roland; Orthous-Daunay, Francois-Régis; Vuitton, Véronique

2016-03-24

It is an important but also a challenging analytical problem to understand the chemical composition and structure of prebiotic organic matter that is present in extraterrestrial materials. Its formation, evolution and content in the building blocks ("seeds") for more complex molecules, such as proteins and DNA, are key questions in the field of exobiology. Ultrahigh resolution mass spectrometry is one of the best analytical techniques that can be applied because it provides reliable information on the chemical composition and structure of individual components of complex organic mixtures. Prebiotic organic material is delivered to Earth by meteorites or generated in laboratories in simulation (model) experiments that mimic space or atmospheric conditions. Recent representative examples for ultrahigh resolution mass spectrometry studies using Fourier-transform (FT) mass spectrometers such as Orbitrap and ion cyclotron resonance (ICR) mass spectrometers are shown and discussed in the present article, including: (i) the analysis of organic matter of meteorites; (ii) modeling atmospheric processes in ICR cells; and (iii) the structural analysis of laboratory made tholins that might be present in the atmosphere and surface of Saturn's largest moon, Titan.

Ultrahigh speed en face OCT capsule for endoscopic imaging

PubMed Central

Liang, Kaicheng; Traverso, Giovanni; Lee, Hsiang-Chieh; Ahsen, Osman Oguz; Wang, Zhao; Potsaid, Benjamin; Giacomelli, Michael; Jayaraman, Vijaysekhar; Barman, Ross; Cable, Alex; Mashimo, Hiroshi; Langer, Robert; Fujimoto, James G.

2015-01-01

Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or advancing the capsule while scanning the distal high-speed micromotor. Circumferential en face OCT was demonstrated in living swine at 250 Hz frame rate and 1 MHz A-scan rate using a MEMS tunable VCSEL light source at 1300 nm. Cross-sectional and en face OCT views of the upper and lower gastrointestinal tract were generated with precision distal pneumatic longitudinal actuation as well as proximal manual longitudinal actuation. These devices could enable clinical studies either as an adjunct to endoscopy, attached to an endoscope, or as a swallowed tethered capsule for non-endoscopic imaging without sedation. The combination of ultrahigh speed imaging and distal scanning capsule technology could enable both screening and surveillance applications. PMID:25909001

Ultrahigh speed en face OCT capsule for endoscopic imaging.

PubMed

Liang, Kaicheng; Traverso, Giovanni; Lee, Hsiang-Chieh; Ahsen, Osman Oguz; Wang, Zhao; Potsaid, Benjamin; Giacomelli, Michael; Jayaraman, Vijaysekhar; Barman, Ross; Cable, Alex; Mashimo, Hiroshi; Langer, Robert; Fujimoto, James G

2015-04-01

Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or advancing the capsule while scanning the distal high-speed micromotor. Circumferential en face OCT was demonstrated in living swine at 250 Hz frame rate and 1 MHz A-scan rate using a MEMS tunable VCSEL light source at 1300 nm. Cross-sectional and en face OCT views of the upper and lower gastrointestinal tract were generated with precision distal pneumatic longitudinal actuation as well as proximal manual longitudinal actuation. These devices could enable clinical studies either as an adjunct to endoscopy, attached to an endoscope, or as a swallowed tethered capsule for non-endoscopic imaging without sedation. The combination of ultrahigh speed imaging and distal scanning capsule technology could enable both screening and surveillance applications.

Identification of characteristic frequencies of damaged railway tracks using field hammer test measurements

NASA Astrophysics Data System (ADS)

Oregui, M.; Li, Z.; Dollevoet, R.

2015-03-01

In this paper, the feasibility of the Frequency Response Function (FRF)-based statistical method to identify the characteristic frequencies of railway track defects is studied. The method compares a damaged track state to a healthy state based on non-destructive field hammer test measurements. First, a study is carried out to investigate the repeatability of hammer tests in railway tracks. By changing the excitation and measurement locations it is shown that the variability introduced by the test process is negligible. Second, following the concepts of control charts employed in process monitoring, a method to define an approximate healthy state is introduced by using hammer test measurements at locations without visual damage. Then, the feasibility study includes an investigation into squats (i.e. a major type of rail surface defect) of varying severity. The identified frequency ranges related to squats agree with those found in an extensively validated vehicle-borne detection system. Therefore, the FRF-based statistical method in combination with the non-destructive hammer test measurements has the potential to be employed to identify the characteristic frequencies of damaged conditions in railway tracks in the frequency range of 300-3000 Hz.

MDOT aims for lower-cost ultra-high performance concrete : research spotlight.

DOT National Transportation Integrated Search

2016-08-01

In recent years, several vendors have developed ultra-high performance : concrete (UHPC) that surpasses traditional concrete mixes by offering : exceptional freeze-thaw resistance, reduced susceptibility to cracking : and far less reinforcement corro...

Ultrahigh-resolution optical coherence tomography with a fiber laser source at 1 microm.

PubMed

Lim, Hyungsik; Jiang, Yi; Wang, Yimin; Huang, Yu-Chih; Chen, Zhongping; Wise, Frank W

2005-05-15

We report a compact, high-power, fiber-based source for ultrahigh-resolution optical coherence tomography (OCT) near 1 microm. The practical source is based on a short-pulse, ytterbium-doped fiber laser and on generation of a continuum spectrum in a photonic crystal fiber. The broadband emission has an average power of 140 mW and offers an axial resolution of 2.1 microm in air (<1.6 microm in biological tissue). The generation of a broad bandwidth is robust and efficient. We demonstrate ultrahigh-resolution, time-domain OCT imaging of in vitro and in vivo biological tissues.

Cellular and molecular pathways of extremely-low-frequency electromagnetic field interactions with living systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tenforde, T.S.

1992-06-01

There is growing evidence that environmental electric and magnetic fields in the extremely-low-frequency (ELF) band below 300 Hz can influence biological functions by mechanisms that are only poorly understood at the present time. The primary objectives of this paper are to review the physical properties of ELF fields, their interactions with living systems at the tissue, cellular, and subcellular levels, and the key role of cell membranes ;in the transduction of signals from imposed ELF fields. Topics of discussion include signal-to-noise ratios for single cells and cell aggregates, resonance phenomena involving a combination of static and ELF magnetic fields, andmore » the possible influence of ELF fields on molecular signaling pathways that involve membrane receptors and cytoplasmic second messengers.« less

Ionization-Assisted Getter Pumping for Ultra-Stable Trapped Ion Frequency Standards

NASA Technical Reports Server (NTRS)

Tjoelker, Robert L.; Burt, Eric A.

2010-01-01

A method eliminates (or recovers from) residual methane buildup in getter-pumped atomic frequency standard systems by applying ionizing assistance. Ultra-high stability trapped ion frequency standards for applications requiring very high reliability, and/or low power and mass (both for ground-based and space-based platforms) benefit from using sealed vacuum systems. These systems require careful material selection and system processing (cleaning and high-temperature bake-out). Even under the most careful preparation, residual hydrogen outgassing from vacuum chamber walls typically limits the base pressure. Non-evaporable getter pumps (NEGs) provide a convenient pumping option for sealed systems because of low mass and volume, and no power once activated. An ion gauge in conjunction with a NEG can be used to provide a low mass, low-power method for avoiding the deleterious effects of methane buildup in high-performance frequency standard vacuum systems.

Study of Ultra-High Energy Cosmic Rays from Extensive Air Showers Radio Emission

NASA Astrophysics Data System (ADS)

Petrov, Igor; Kozlov, Vladimir; Petrov, Zim; Knurenko, Stanislav; Pravdin, Mikhail

The study of cosmic rays with the help of radio detection from extensive air showers may be an alternative to traditional detecting methods, which use a large area array installed with hundreds and thousands of scintillation detectors for charged particles, or the detectors of measuring the emission produced by relativistic particles of EAS in the optical wavelengths. Processes that lead to the emission of electromagnetic radiation are well known and calculations show that the air shower radio emission depends on the processes of development of the electromagnetic cascade, i.e. related with the longitudinal development of the shower, with the magnetic field near sea level etc. In this regard, there is a question to establish the correlation between characteristics of EAS both longitudinal and lateral development and radio emission parameters observed when air shower particles pass through the atmosphere. For this purpose, in Yakutsk, radio array for detecting air shower radio emission was established. The array consists of the antenna field on which crossed antennas are installed; antennas oriented E - W and N - S. Radio emission measurements are conducted at frequency 32 MHz, free from industrial noise. In 2008 - 2013 years, Yakutsk array has measured several seasons of registration of EAS events, including showers with energies above 10 (19) eV. In the course of the data analysis the following results were obtained: a) lateral distribution of the radio signal plotted as a function of distance from the shower axis ; b) a correlation between the amplitude of the radio signal with the energy of the shower, which is determined by measuring the fluxes of charged particles , muons and EAS Cerenkov radiation (energy balance method); c) we made evaluation of the depth of maximum development of the shower using form of radio emission LDF measured in ultra-high energy showers; g) a comparison of the Yakutsk array data with data from other arrays.

The alteration of spontaneous low frequency oscillations caused by acute electromagnetic fields exposure.

PubMed

Lv, Bin; Chen, Zhiye; Wu, Tongning; Shao, Qing; Yan, Duo; Ma, Lin; Lu, Ke; Xie, Yi

2014-02-01

The motivation of this study is to evaluate the possible alteration of regional resting state brain activity induced by the acute radiofrequency electromagnetic field (RF-EMF) exposure (30min) of Long Term Evolution (LTE) signal. We designed a controllable near-field LTE RF-EMF exposure environment. Eighteen subjects participated in a double-blind, crossover, randomized and counterbalanced experiment including two sessions (real and sham exposure). The radiation source was close to the right ear. Then the resting state fMRI signals of human brain were collected before and after the exposure in both sessions. We measured the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) to characterize the spontaneous brain activity. We found the decreased ALFF value around in left superior temporal gyrus, left middle temporal gyrus, right superior temporal gyrus, right medial frontal gyrus and right paracentral lobule after the real exposure. And the decreased fALFF value was also detected in right medial frontal gyrus and right paracentral lobule. The study provided the evidences that 30min LTE RF-EMF exposure modulated the spontaneous low frequency fluctuations in some brain regions. With resting state fMRI, we found the alteration of spontaneous low frequency fluctuations induced by the acute LTE RF-EMF exposure. Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

High- and ultrahigh-field magnetic resonance imaging of naïve, injured and scarred vocal fold mucosae in rats.

PubMed

Kishimoto, Ayami Ohno; Kishimoto, Yo; Young, David L; Zhang, Jinjin; Rowland, Ian J; Welham, Nathan V

2016-11-01

Subepithelial changes to the vocal fold mucosa, such as fibrosis, are difficult to identify using visual assessment of the tissue surface. Moreover, without suspicion of neoplasm, mucosal biopsy is not a viable clinical option, as it carries its own risk of iatrogenic injury and scar formation. Given these challenges, we assessed the ability of high- (4.7 T) and ultrahigh-field (9.4 T) magnetic resonance imaging to resolve key vocal fold subepithelial tissue structures in the rat, an important and widely used preclinical model in vocal fold biology. We conducted serial in vivo and ex vivo imaging, evaluated an array of acquisition sequences and contrast agents, and successfully resolved key anatomic features of naïve, acutely injured, and chronically scarred vocal fold mucosae on the ex vivo scans. Naïve lamina propria was hyperintense on T1-weighted imaging with gadobenate dimeglumine contrast enhancement, whereas chronic scar was characterized by reduced lamina propria T1 signal intensity and mucosal volume. Acutely injured mucosa was hypointense on T2-weighted imaging; lesion volume steadily increased, peaked at 5 days post-injury, and then decreased - consistent with the physiology of acute, followed by subacute, hemorrhage and associated changes in the magnetic state of hemoglobin and its degradation products. Intravenous administration of superparamagnetic iron oxide conferred no T2 contrast enhancement during the acute injury period. These findings confirm that magnetic resonance imaging can resolve anatomic substructures within naïve vocal fold mucosa, qualitative and quantitative features of acute injury, and the presence of chronic scar. © 2016. Published by The Company of Biologists Ltd.

High- and ultrahigh-field magnetic resonance imaging of naïve, injured and scarred vocal fold mucosae in rats

PubMed Central

Kishimoto, Ayami Ohno; Kishimoto, Yo; Young, David L.; Zhang, Jinjin

2016-01-01

ABSTRACT Subepithelial changes to the vocal fold mucosa, such as fibrosis, are difficult to identify using visual assessment of the tissue surface. Moreover, without suspicion of neoplasm, mucosal biopsy is not a viable clinical option, as it carries its own risk of iatrogenic injury and scar formation. Given these challenges, we assessed the ability of high- (4.7 T) and ultrahigh-field (9.4 T) magnetic resonance imaging to resolve key vocal fold subepithelial tissue structures in the rat, an important and widely used preclinical model in vocal fold biology. We conducted serial in vivo and ex vivo imaging, evaluated an array of acquisition sequences and contrast agents, and successfully resolved key anatomic features of naïve, acutely injured, and chronically scarred vocal fold mucosae on the ex vivo scans. Naïve lamina propria was hyperintense on T1-weighted imaging with gadobenate dimeglumine contrast enhancement, whereas chronic scar was characterized by reduced lamina propria T1 signal intensity and mucosal volume. Acutely injured mucosa was hypointense on T2-weighted imaging; lesion volume steadily increased, peaked at 5 days post-injury, and then decreased – consistent with the physiology of acute, followed by subacute, hemorrhage and associated changes in the magnetic state of hemoglobin and its degradation products. Intravenous administration of superparamagnetic iron oxide conferred no T2 contrast enhancement during the acute injury period. These findings confirm that magnetic resonance imaging can resolve anatomic substructures within naïve vocal fold mucosa, qualitative and quantitative features of acute injury, and the presence of chronic scar. PMID:27638667

Review of russian literature on biological action of DC and low-frequency AC magnetic fields.

PubMed

Zhadin, M N

2001-01-01

This review considers the Russian scientific literature on the influence of weak static and of low-frequency alternating magnetic fields on biological systems. The review covers the most interesting works and the main lines of investigation during the period 1900 to the present. Shown here are the historical roots, beginning with the ideas of V. Vernadsky and A. Chizhevsky, which led in the field of Russian biology to an increasing interest in magnetic fields, based on an intimate connection between solar activity and life on the Earth, and which determined the peculiar development of Russian magnetobiology. The variety of studies on the effects of magnetic storms and extremely low-frequency, periodic variations of the geomagnetic field on human beings and animals as well as on social phenomena are described. The diverse experiments involving artificial laboratory magnetic fields acting on different biological entities under different conditions are also considered. A series of theoretical advances are reviewed that have paved the way for a step-by-step understanding of the mechanisms of magnetic field effects on biological systems. The predominantly unfavorable influence of magnetic fields on living beings is shown, but the cases of favorable influence of magnetic fields on human beings and lower animals are demonstrated as well. The majority of Russian investigations in this area of science has been unknown among the non-Russian speaking audience for many reasons, primarily because of a language barrier. Therefore, it is hoped that this review may be of interest to the international scientific community. Copyright 2001 Wiley-Liss, Inc.

Frequency agile microwave photonic notch filter with anomalously high stopband rejection.

PubMed

Marpaung, David; Morrison, Blair; Pant, Ravi; Eggleton, Benjamin J

2013-11-01

We report a novel class microwave photonic (MWP) notch filter with a very narrow isolation bandwidth (10 MHz), an ultrahigh stopband rejection (>60 dB), a wide frequency tuning (1-30 GHz), and flexible bandwidth reconfigurability (10-65 MHz). This performance is enabled by a new concept of sideband amplitude and phase controls using an electro-optic modulator and an optical filter. This concept enables energy efficient operation in active MWP notch filters, and opens up a pathway toward enabling low-power nanophotonic devices as high-performance RF filters.

Development of Non-Proprietary Ultra-High Performance Concrete : Project Summary Report

DOT National Transportation Integrated Search

2017-12-01

Ultra-high performance concrete (UHPC) has mechanical and durability properties that far exceed those of conventional concrete. Thus, elements made with UHPC can be thinner/lighter than elements made with conventional concrete. The enhanced durabilit...

Possible Mechanism of Action of the Electromagnetic Fields of Ultralow Frequency on G-protein

NASA Astrophysics Data System (ADS)

Nava, J. J. Godina; Segura, M. A. Rodríguez; García, M. N. Jiménez; Cadena, M. S. Reyes

2008-08-01

Based in several clinical achievements and mathematical simulation of the immune sytem, previously studied, permit us to establish that a possible Mechanism of Action of ultralow frequency Electromagnetic Fields (ELF) is on G-protein as it has been proposed in specialized literature.

Effect of Electric Field Gradient on Sub-nanometer Spatial Resolution of Tip-enhanced Raman Spectroscopy

PubMed Central

Meng, Lingyan; Yang, Zhilin; Chen, Jianing; Sun, Mengtao

2015-01-01

Tip-enhanced Raman spectroscopy (TERS) with sub-nanometer spatial resolution has been recently demonstrated experimentally. However, the physical mechanism underlying is still under discussion. Here we theoretically investigate the electric field gradient of a coupled tip-substrate system. Our calculations suggest that the ultra-high spatial resolution of TERS can be partially attributed to the electric field gradient effect owning to its tighter spatial confinement and sensitivity to the infrared (IR)-active of molecules. Particularly, in the case of TERS of flat-lying H2TBPP molecules,we find the electric field gradient enhancement is the dominating factor for the high spatial resolution, which qualitatively coincides with previous experimental report. Our theoretical study offers a new paradigm for understanding the mechanisms of the ultra-high spatial resolution demonstrated in tip-enhanced spectroscopy which is of importance but neglected. PMID:25784161

Efficacy of dietary supplement with nutraceutical composed combined with extremely-low-frequency electromagnetic fields in carpal tunnel syndrome

PubMed Central

Paolucci, Teresa; Piccinini, Giulia; Nusca, Sveva Maria; Marsilli, Gabriella; Mannocci, Alice; La Torre, Giuseppe; Saraceni, Vincenzo Maria; Vulpiani, Maria Chiara; Villani, Ciro

2018-01-01

[Purpose] The aim of this study was to investigate the clinical effects of a nutraceutical composed (Xinepa®) combined with extremely-low-frequency electromagnetic fields in the carpal tunnel syndrome. [Subjects and Methods] Thirty-one patients with carpal tunnel syndrome were randomized into group 1-A (N=16) (nutraceutical + extremely-low-frequency electromagnetic fields) and group 2-C (n=15) (placebo + extremely-low-frequency electromagnetic fields). The dietary supplement with nutraceutical was twice daily for one month in the 1-A group and both groups received extremely-low-frequency electromagnetic fields at the level of the carpal tunnel 3 times per week for 12 sessions. The Visual Analogue Scale for pain, the Symptoms Severity Scale and Functional Severity Scale of the Boston Carpal Tunnel Questionnaire were used at pre-treatment (T0), after the end of treatment (T1) and at 3 months post-treatment (T2). [Results] At T1 and T2 were not significant differences in outcome measures between the two groups. In group 1-A a significant improvement in the scales were observed at T1 and T2. In group 2-C it was observed only at T1. [Conclusion] Significant clinical effects from pre-treatment to the end of treatment were shown in both groups. Only in group 1-A they were maintained at 3 months post-treatment.

An ultrahigh pressure homogenization technique for easily exfoliating few-layer phosphorene from bulk black phosphorus

NASA Astrophysics Data System (ADS)

Guan, Qing-Qing; Zhou, Hua-Jing; Ning, Ping; Lian, Pei-Chao; Wang, Bo; He, Liang; Chai, Xin-Sheng

2018-05-01

We have developed an easy and efficient method for exfoliating few-layer sheets of black phosphorus (BP) in N-methyl-2-pyrrolidone, using ultra-high pressure homogenization (UPH). The BP was first exfoliated into sheets that were a few atomic layers thick, using a homogenizer for only 30 min. Next, a double centrifugation procedure was used to separate the material into few-layer nanosheets that were examined by X-ray diffraction, atomic force microscopy (AFM), transmission electron microscopy (TEM), high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM), and energy-dispersive X-ray (EDX) spectroscopy. The results show that the products are specimens of phosphorene that are only a few-layer thick.

Towards ultrahigh resting-state functional connectivity in the mouse brain using photoacoustic microscopy

NASA Astrophysics Data System (ADS)

Hariri, Ali; Bely, Nicholas; Chen, Chen; Nasiriavanaki, Mohammadreza

2016-03-01

The increasing use of mouse models for human brain disease studies, coupled with the fact that existing high-resolution functional imaging modalities cannot be easily applied to mice, presents an emerging need for a new functional imaging modality. Utilizing both mechanical and optical scanning in the photoacoustic microscopy, we can image spontaneous cerebral hemodynamic fluctuations and their associated functional connections in the mouse brain. The images is going to be acquired noninvasively with a fast frame rate, a large field of view, and a high spatial resolution. We developed an optical resolution photoacoustic microscopy (OR-PAM) with diode laser. Laser light was raster scanned due to XY-stage movement. Images from ultra-high OR-PAM can then be used to study brain disorders such as stroke, Alzheimer's, schizophrenia, multiple sclerosis, autism, and epilepsy.

Frequency locking of a field-widened Michelson interferometer based on optimal multi-harmonics heterodyning.

PubMed

Cheng, Zhongtao; Liu, Dong; Zhou, Yudi; Yang, Yongying; Luo, Jing; Zhang, Yupeng; Shen, Yibing; Liu, Chong; Bai, Jian; Wang, Kaiwei; Su, Lin; Yang, Liming

2016-09-01

A general resonant frequency locking scheme for a field-widened Michelson interferometer (FWMI), which is intended as a spectral discriminator in a high-spectral-resolution lidar, is proposed based on optimal multi-harmonics heterodyning. By transferring the energy of a reference laser to multi-harmonics of different orders generated by optimal electro-optic phase modulation, the heterodyne signal of these multi-harmonics through the FWMI can reveal the resonant frequency drift of the interferometer very sensitively within a large frequency range. This approach can overcome the locking difficulty induced by the low finesse of the FWMI, thus contributing to excellent locking accuracy and lock acquisition range without any constraint on the interferometer itself. The theoretical and experimental results are presented to verify the performance of this scheme.

Low-frequency (1/f) noise in nanocrystal field-effect transistors.

PubMed

Lai, Yuming; Li, Haipeng; Kim, David K; Diroll, Benjamin T; Murray, Christopher B; Kagan, Cherie R

2014-09-23

We investigate the origins and magnitude of low-frequency noise in high-mobility nanocrystal field-effect transistors and show the noise is of 1/f-type. Sub-band gap states, in particular, those introduced by nanocrystal surfaces, have a significant influence on the 1/f noise. By engineering the device geometry and passivating nanocrystal surfaces, we show that in the linear and saturation regimes the 1/f noise obeys Hooge's model of mobility fluctuations, consistent with transport of a high density of accumulated carriers in extended electronic states of the NC thin films. In the subthreshold regime, the Fermi energy moves deeper into the mobility gap and sub-band gap trap states give rise to a transition to noise dominated by carrier number fluctuations as described in McWhorter's model. CdSe nanocrystal field-effect transistors have a Hooge parameter of 3 × 10(-2), comparable to other solution-deposited, thin-film devices, promising high-performance, low-cost, low-noise integrated circuitry.

Development of a Family of Ultra-High Performance Concrete Pi-Girders

DOT National Transportation Integrated Search

2014-01-01

Ultra-high performance concrete (UHPC) is an advanced cementitious composite material, which tends to exhibit superior properties such as exceptional durability, increased strength, and long-term stability. (See references 1-4.) The use of existing s...

Ultra-high performance concrete for Michigan bridges, material performance : phase I.

DOT National Transportation Integrated Search

2008-10-13

One of the latest advancements in concrete technology is Ultra-High Performance Concrete (UHPC). UHPC is : defined as concretes attaining compressive strengths exceeding 25 ksi (175 MPa). It is a fiber-reinforced, denselypacked : concrete material wh...

Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model

NASA Astrophysics Data System (ADS)

Sunderam, Sridhar; Chernyy, Nick; Peixoto, Nathalia; Mason, Jonathan P.; Weinstein, Steven L.; Schiff, Steven J.; Gluckman, Bruce J.

2009-08-01

Neural activity can be modulated by applying a polarizing low-frequency (Lt100 Hz) electric field (PLEF). Unlike conventional pulsed stimulation, PLEF stimulation has a graded, modulatory effect on neuronal excitability, and permits the simultaneous recording of neuronal activity during stimulation suitable for continuous feedback control. We tested a prototype system that allows for simultaneous PLEF stimulation with minimal recording artifact in a chronic tetanus toxin animal model (rat) of hippocampal epilepsy with spontaneous seizures. Depth electrode local field potentials recorded during seizures revealed a characteristic pattern of field postsynaptic potentials (fPSPs). Sinusoidal voltage-controlled PLEF stimulation (0.5-25 Hz) was applied in open-loop cycles radially across the CA3 of ventral hippocampus. For stimulated seizures, fPSPs were transiently entrained with the PLEF waveform. Statistical significance of entrainment was assessed with Thomson's harmonic F-test, with 45/132 stimulated seizures in four animals individually demonstrating significant entrainment (p < 0.04). Significant entrainment for multiple presentations at the same frequency (p < 0.01) was observed in three of four animals in 42/64 stimulated seizures. This is the first demonstration in chronically implanted freely behaving animals of PLEF modulation of neural activity with simultaneous recording.

Searching for New Physics with Ultrahigh Energy Cosmic Rays

NASA Technical Reports Server (NTRS)

Stecker, Floyd W.; Scully, Sean T.

2009-01-01

Ultrahigh energy cosmic rays that produce giant extensive showers of charged particles and photons when they interact in the Earth's atmosphere provide a unique tool to search for new physics. Of particular interest is the possibility of detecting a very small violation of Lorentz invariance such as may be related to the structure of space-time near the Planck scale of approximately 10 (exp -35) m. We discuss here the possible signature of Lorentz invariance violation on the spectrum of ultrahigh energy cosmic rays as compared with present observations of giant air showers. We also discuss the possibilities of using more sensitive detection techniques to improve searches for Lorentz invariance violation in the future. Using the latest data from the Pierre Auger Observatory, we derive a best fit to the LIV parameter of 3 .0 + 1.5 - 3:0 x 10 (exp -23) ,corresponding to an upper limit of 4.5 x 10-23 at a proton Lorentz factor of approximately 2 x 10(exp 11) . This result has fundamental implications for quantum gravity models.

Microfluidic active mixers employing ultra-high aspect-ratio rare-earth magnetic nano-composite polymer artificial cilia

NASA Astrophysics Data System (ADS)

Rahbar, Mona; Shannon, Lesley; Gray, Bonnie L.

2014-02-01

We present a new micromixer based on highly magnetic, flexible, high aspect-ratio, artificial cilia that are fabricated as individual micromixer elements or in arrays for improved mixing performance. These new cilia enable high efficiency, fast mixing in a microchamber, and are controlled by small electromagnetic fields. The artificial cilia are fabricated using a new micromolding process for nano-composite polymers. Cilia fibers with aspect-ratios as high as 8:0.13 demonstrate the fabrication technique's capability in creating ultra-high aspect-ratio microstructures. Cilia, which are realized in polydimethylsiloxane doped with rare-earth magnetic powder, are magnetized to produce permanent magnetic structures with bidirectional deflection capabilities, making them highly suitable as mixers controlled by electromagnetic fields. Due to the high magnetization level of the polarized nano-composite polymer, we are able to use miniature electromagnets providing relatively small magnetic fields of 1.1 to 7 mT to actuate the cilia microstructures over a very wide motion range. Mixing performances of a single cilium, as well as different arrays of multiple cilia ranging from 2 to 8 per reaction chamber, are characterized and compared with passive diffusion mixing performance. The mixer cilia are actuated at different amplitudes and frequencies to optimize mixing performance. We demonstrate that more than 85% of the total volume of the reaction chamber is fully mixed after 3.5 min using a single cilium mixer at 7 mT compared with only 20% of the total volume mixed with passive diffusion. The time to achieve over 85% mixing is further reduced to 70 s using an array of eight cilia microstructures. The novel microfabrication technique and use of rare-earth permanently-magnetizable nano-composite polymers in mixer applications has not been reported elsewhere by other researchers. We further demonstrate improved mixing over other cilia micromixers as enabled by the high aspect

Ultrahigh Elastic Strain Energy Storage in Metal-Oxide-Infiltrated Patterned Hybrid Polymer Nanocomposites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dusoe, Keith J.; Ye, Xinyi; Kisslinger, Kim

Modulus of resilience, the measure of a material’s capacity to store and release elastic strain energy, is critical for realizing advanced mechanical actuation technologies in micro/nanoelectromechanical systems. In general, engineering the modulus of resilience is difficult because it requires asymmetrically increasing yield strength and Young’s modulus against their mutual scaling behavior. This task becomes further challenging if it needs to be carried out at the nanometer scale. Here, we demonstrate organic–inorganic hybrid composite nanopillars with one of the highest modulus of resilience per density by utilizing vapor-phase aluminum oxide infiltration in lithographically patterned negative photoresist SU-8. In situ nanomechanical measurementsmore » reveal a metal-like high yield strength (~500 MPa) with an unusually low, foam-like Young’s modulus (~7 GPa), a unique pairing that yields ultrahigh modulus of resilience, reaching up to ~24 MJ/m 3 as well as exceptional modulus of resilience per density of ~13.4 kJ/kg, surpassing those of most engineering materials. The hybrid polymer nanocomposite features lightweight, ultrahigh tunable modulus of resilience and versatile nanoscale lithographic patternability with potential for application as nanomechanical components which require ultrahigh mechanical resilience and strength.« less

Ultrahigh Elastic Strain Energy Storage in Metal-Oxide-Infiltrated Patterned Hybrid Polymer Nanocomposites

DOE PAGES

Dusoe, Keith J.; Ye, Xinyi; Kisslinger, Kim; ...

2017-10-19

Modulus of resilience, the measure of a material’s capacity to store and release elastic strain energy, is critical for realizing advanced mechanical actuation technologies in micro/nanoelectromechanical systems. In general, engineering the modulus of resilience is difficult because it requires asymmetrically increasing yield strength and Young’s modulus against their mutual scaling behavior. This task becomes further challenging if it needs to be carried out at the nanometer scale. Here, we demonstrate organic–inorganic hybrid composite nanopillars with one of the highest modulus of resilience per density by utilizing vapor-phase aluminum oxide infiltration in lithographically patterned negative photoresist SU-8. In situ nanomechanical measurementsmore » reveal a metal-like high yield strength (~500 MPa) with an unusually low, foam-like Young’s modulus (~7 GPa), a unique pairing that yields ultrahigh modulus of resilience, reaching up to ~24 MJ/m 3 as well as exceptional modulus of resilience per density of ~13.4 kJ/kg, surpassing those of most engineering materials. The hybrid polymer nanocomposite features lightweight, ultrahigh tunable modulus of resilience and versatile nanoscale lithographic patternability with potential for application as nanomechanical components which require ultrahigh mechanical resilience and strength.« less

Low-frequency pulsed electromagnetic fields significantly improve time of closure and proliferation of human tendon fibroblasts

PubMed Central

2014-01-01

Background The promotion of the healing process following musculoskeletal injuries comprises growth factor signalling, migration, proliferation and apoptosis of cells. If these processes could be modulated, the healing of tendon tissue may be markedly enhanced. Here, we report the use of the Somagen™ device, which is certified for medical use according to European laws. It generates low-frequency pulsed electromagnetic fields that trigger effects of a nature that are yet to be determined. Methods A 1.5-cm wide, linear scrape was introduced into patellar tendon fibroblast cultures (N = 5 donors). Treatment was carried out every second day. The regimen was applied three times in total with 30 minutes comprising pulsed electromagnetic field packages with two fundamental frequencies (10 minutes of 33 Hz, 20 minutes of 7.8 Hz). Control cells remained untreated. All samples were analyzed for gap closure time, proliferation and apoptosis one week after induction of the scrape wound. Results The mean time for bridging the gap in the nontreated cells was 5.05 ± 0.33 days, and in treated cells, it took 3.35 ± 0.38 days (P <0.001). For cell cultures with scrape wounds, a mean value for BrdU incorporation of OD = 0.70 ± 0.16 was found. Whereas low-frequency pulsed electromagnetic fields treated samples showed OD = 1.58 ± 0.24 (P <0.001). However, the percentage of apoptotic cells did not differ between the two groups. Conclusions Our data demonstrate that low-frequency pulsed electromagnetic fields emitted by the Somagen™ device influences the in vitro wound healing of patellar tendon fibroblasts and, therefore, possibly increases wound healing potential. PMID:24996421

Reversal Frequency, Core-Mantle Conditions, and the SCOR-field Hypothesis

NASA Astrophysics Data System (ADS)

Hoffman, K. A.

2009-12-01

One of the most intriguing results from paleomagnetic data spanning the past 108 yr comes from the work of McFadden et al. (1991) who found that the variation in the rate of polarity reversal is apparently tied to the temporal variation in the harmonic content of the full-polarity field. Their finding indicates that it is the relative importance of the two dynamo families--i.e. the Primary Family (PF), the field antisymmetric about the equator, and the Secondary Family (SF), the field symmetric about the equator--that largely determines reversal frequency. More specifically, McFadden et al. found that as the relative significance of the SF increases, as is observed during the Cenozoic, so too does reversal rate. Such a finding is reminiscent of the seminal work of Allan Cox who some forty years ago proposed that interactions with the non-dipole field may provide the trigger for reversal of the axial dipole (AD) field. Hence, new questions arise: Do the two dynamo family fields interact in this manner, and, if so, how can such an interaction physically occur in the fluid core? Gaussian coefficient terms comprising the PF and SF have degree and order (n + m) that sum to an odd and even number, respectively. The most significant field term in the PF is by far that of the axial dipole (g10). The entire SF, starting with the equatorial dipole terms (g11 and h11) and the axial quadrupole (g20), are constituents of the non-axial dipole (NAD) field. By way of both paleomagnetic transition and geomagnetic data Hoffman and Singer (2008) recently proposed (1) that field sources exist within the shallow core (SCOR-field) associated with fluid motions affected by long-lived core-mantle boundary conditions; (2) that these SCOR-field sources are largely separated from, i.e. in “poor communication” with, deep field convection roll-generated sources; and (3) that the deep sources are largely responsible for the AD field, leaving the SCOR-field to be the primary source for the

A superhigh-frequency optoelectromechanical system based on a slotted photonic crystal cavity

NASA Astrophysics Data System (ADS)

Sun, Xiankai; Zhang, Xufeng; Poot, Menno; Xiong, Chi; Tang, Hong X.

2012-11-01

We develop an all-integrated optoelectromechanical system that operates in the superhigh frequency band. This system is based on an ultrahigh-Q slotted photonic crystal (PhC) nanocavity formed by two PhC membranes, one of which is patterned with electrode and capacitively driven. The strong simultaneous electromechanical and optomechanical interactions yield efficient electrical excitation and sensitive optical transduction of the bulk acoustic modes of the PhC membrane. These modes are identified up to a frequency of 4.20 GHz, with their mechanical Q factors ranging from 240 to 1730. Directly linking signals in microwave and optical domains, such optoelectromechanical systems will find applications in microwave photonics in addition to those that utilize the electromechanical and optomechanical interactions separately.

Spectrally narrow, long-term stable optical frequency reference based on a Eu3+:Y2SiO5 crystal at cryogenic temperature.

PubMed

Chen, Qun-Feng; Troshyn, Andrei; Ernsting, Ingo; Kayser, Steffen; Vasilyev, Sergey; Nevsky, Alexander; Schiller, Stephan

2011-11-25

Using an ultrastable continuous-wave laser at 580 nm we performed spectral hole burning of Eu(3+):Y(2)SiO(5) at a very high spectral resolution. The essential parameters determining the usefulness as a macroscopic frequency reference, linewidth, temperature sensitivity, and long-term stability, were characterized using a H-maser stabilized frequency comb. Spectral holes with a linewidth as low as 6 kHz were observed and the upper limit of the drift of the hole frequency was determined to be 5±3 mHz/s. We discuss the necessary requirements for achieving ultrahigh stability in laser frequency stabilization to these spectral holes.

Experimental system for drilling simulated lunar rock in ultrahigh vacuum

NASA Technical Reports Server (NTRS)

Roepke, W. W.

1975-01-01

An experimental apparatus designed for studying drillability of hard volcanic rock in a simulated lunar vacuum of 5 x 10 to the minus 10th power torr is described. The engineering techniques used to provide suitable drilling torque inside the ultrahigh vacuum chamber while excluding all hydrocarbon are detailed. Totally unlubricated bearings and gears were used to better approximate the true lunar surface conditions within the ultrahigh vacuum system. The drilling system has a starting torque of 30 in-lb with an unloaded running torque of 4 in-lb. Nominal torque increase during drilling is 4.5 in-lb or a total drilling torque of 8.5 in-lb with a 100-lb load on the drill bit at 210 rpm. The research shows conclusively that it is possible to design operational equipment for moderate loads operating under UHV conditions without the use of sealed bearings or any need of lubricants whatsoever.

Implications of Ultrahigh Energy Air Showers for Physics and Astrophysics

NASA Technical Reports Server (NTRS)

Stecker, F. W.; White, Nicholas E. (Technical Monitor)

2002-01-01

The primary ultrahigh energy particles which produce giant extensive air showers in the Earth atmosphere present an intriguing mystery from two points of view: (1) How are the base particles produced with such astounding energies, eight orders of magnitude higher than those produced by the best man-made terrestrial accelerators? (2) Since they are most likely extragalactic in origin, how do they reach us from extragalactic distances without suffering the severe losses expected from interactions with the 2.7 K thermal cosmic background photons, the so called GZK effect? The answers to these questions may involve new physics: violations of special relativity, grand unification theories, and quantum gravity theories involving large extra dimensions. They may involve new astrophysical sources, "zevatrons". Or some heretofore totally unknown physics or astrophysics may hold the answer. I will discuss here the mysteries involving the production and extragalactic propagation of ultrahigh energy cosmic rays and some suggested possible solutions.

Digital image analysis to quantify carbide networks in ultrahigh carbon steels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hecht, Matthew D.; Webler, Bryan A.; Picard, Yoosuf N., E-mail: ypicard@cmu.edu

A method has been developed and demonstrated to quantify the degree of carbide network connectivity in ultrahigh carbon steels through digital image processing and analysis of experimental micrographs. It was shown that the network connectivity and carbon content can be correlated to toughness for various ultrahigh carbon steel specimens. The image analysis approach first involved segmenting the carbide network and pearlite matrix into binary contrast representations via a grayscale intensity thresholding operation. Next, the carbide network pixels were skeletonized and parceled into braches and nodes, allowing the determination of a connectivity index for the carbide network. Intermediate image processing stepsmore » to remove noise and fill voids in the network are also detailed. The connectivity indexes of scanning electron micrographs were consistent in both secondary and backscattered electron imaging modes, as well as across two different (50 × and 100 ×) magnifications. Results from ultrahigh carbon steels reported here along with other results from the literature generally showed lower connectivity indexes correlated with higher Charpy impact energy (toughness). A deviation from this trend was observed at higher connectivity indexes, consistent with a percolation threshold for crack propagation across the carbide network. - Highlights: • A method for carbide network analysis in steels is proposed and demonstrated. • ImageJ method extracts a network connectivity index from micrographs. • Connectivity index consistent in different imaging conditions and magnifications. • Impact energy may plateau when a critical network connectivity is exceeded.« less

Length-extension resonator as a force sensor for high-resolution frequency-modulation atomic force microscopy in air.

PubMed

Beyer, Hannes; Wagner, Tino; Stemmer, Andreas

2016-01-01

Frequency-modulation atomic force microscopy has turned into a well-established method to obtain atomic resolution on flat surfaces, but is often limited to ultra-high vacuum conditions and cryogenic temperatures. Measurements under ambient conditions are influenced by variations of the dew point and thin water layers present on practically every surface, complicating stable imaging with high resolution. We demonstrate high-resolution imaging in air using a length-extension resonator operating at small amplitudes. An additional slow feedback compensates for changes in the free resonance frequency, allowing stable imaging over a long period of time with changing environmental conditions.

The Characterization and Circumvention of Carbon Nanotube Junctions - The Route to Practical Carbon Conductors Through Extreme Frequency, Fields, and Light

DTIC Science & Technology

2015-05-22

Conductors Through Extreme Frequency, Fields, and Light Krzysztof Koziol THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERISTY OF CAMBRIDGE...2011 to 31 August 2014 Air Force Research Laboratory Air Force Office of Scientific Research European Office of Aerospace Research and...Carbon Conductors Through Extreme Frequency, Fields, and Light Krzysztof Koziol THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERISTY OF CAMBRIDGE THE

MICROSTRUCTURAL ABNORMALITIES IN MEWDS DEMONSTRATED BY ULTRAHIGH RESOLUTION OPTICAL COHERENCE TOMOGRAPHY

PubMed Central

NGUYEN, MY HANH T.; WITKIN, ANDRE J.; REICHEL, ELIAS; KO, TONY H.; FUJIMOTO, JAMES G.; SCHUMAN, JOEL S.; DUKER, JAY S.

2007-01-01

Background Histopathological studies of acute multiple evanescent white dot syndrome (MEWDS) have not been reported because of the transient and benign nature of the disease. Ultrahigh resolution optical coherence tomography (UHR-OCT), capable of high resolution in vivo imaging, offers a unique opportunity to visualize retinal microstructure in the disease. Methods UHR-OCT images of the maculae of five patients with MEWDS were obtained and analyzed. Diagnosis was based on clinical presentation, examination, visual field testing, and angiography. Results UHR-OCT revealed disturbances in the photoreceptor inner/outer segment junction (IS/OS) in each of the five patients (six eyes) with MEWDS. In addition, thinning of the outer nuclear layer was seen in the case of recurrent MEWDS, suggesting that repeated episodes of MEWDS may result in photoreceptor atrophy. Conclusions Subtle disruptions of the photoreceptor IS/OS are demonstrated in all eyes affected by MEWDS. UHR-OCT may be a useful adjunct to diagnosis and monitoring of MEWDS. PMID:17420691

Microstructural abnormalities in MEWDS demonstrated by ultrahigh resolution optical coherence tomography.

PubMed

Nguyen, My Hanh T; Witkin, Andre J; Reichel, Elias; Ko, Tony H; Fujimoto, James G; Schuman, Joel S; Duker, Jay S

2007-01-01

Histopathological studies of acute multiple evanescent white dot syndrome (MEWDS) have not been reported because of the transient and benign nature of the disease. Ultrahigh resolution optical coherence tomography (UHR-OCT), capable of high resolution in vivo imaging, offers a unique opportunity to visualize retinal microstructure in the disease. UHR-OCT images of the maculae of five patients with MEWDS were obtained and analyzed. Diagnosis was based on clinical presentation, examination, visual field testing, and angiography. UHR-OCT revealed disturbances in the photoreceptor inner/outer segment junction (IS/OS) in each of the five patients (six eyes) with MEWDS. In addition, thinning of the outer nuclear layer was seen in the case of recurrent MEWDS, suggesting that repeated episodes of MEWDS may result in photoreceptor atrophy. Subtle disruptions of the photoreceptor IS/OS are demonstrated in all eyes affected by MEWDS. UHR-OCT may be a useful adjunct to diagnosis and monitoring of MEWDS.

The origin of ultrahigh piezoelectricity in relaxor-ferroelectric solid solution crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Fei; Zhang, Shujun; Yang, Tiannan

The discovery of ultrahigh piezoelectricity in relaxor-ferroelectric solid solution single crystals is a breakthrough in ferroelectric materials. A key signature of relaxor-ferroelectric solid solutions is the existence of polar nanoregions, a nanoscale inhomogeneity, that coexist with normal ferroelectric domains. Despite two decades of extensive studies, the contribution of polar nanoregions to the underlying piezoelectric properties of relaxor ferroelectrics has yet to be established. Here we quantitatively characterize the contribution of polar nanoregions to the dielectric/piezoelectric responses of relaxor-ferroelectric crystals using a combination of cryogenic experiments and phase-field simulations. The contribution of polar nanoregions to the room-temperature dielectric and piezoelectric propertiesmore » is in the range of 50–80%. A mesoscale mechanism is proposed to reveal the origin of the high piezoelectricity in relaxor ferroelectrics, where the polar nanoregions aligned in a ferroelectric matrix can facilitate polarization rotation. This mechanism emphasizes the critical role of local structure on the macroscopic properties of ferroelectric materials.« less

The origin of ultrahigh piezoelectricity in relaxor-ferroelectric solid solution crystals

DOE PAGES

Li, Fei; Zhang, Shujun; Yang, Tiannan; ...

2016-12-19

The discovery of ultrahigh piezoelectricity in relaxor-ferroelectric solid solution single crystals is a breakthrough in ferroelectric materials. A key signature of relaxor-ferroelectric solid solutions is the existence of polar nanoregions, a nanoscale inhomogeneity, that coexist with normal ferroelectric domains. Despite two decades of extensive studies, the contribution of polar nanoregions to the underlying piezoelectric properties of relaxor ferroelectrics has yet to be established. Here we quantitatively characterize the contribution of polar nanoregions to the dielectric/piezoelectric responses of relaxor-ferroelectric crystals using a combination of cryogenic experiments and phase-field simulations. The contribution of polar nanoregions to the room-temperature dielectric and piezoelectric propertiesmore » is in the range of 50–80%. A mesoscale mechanism is proposed to reveal the origin of the high piezoelectricity in relaxor ferroelectrics, where the polar nanoregions aligned in a ferroelectric matrix can facilitate polarization rotation. This mechanism emphasizes the critical role of local structure on the macroscopic properties of ferroelectric materials.« less

MESSENGER Magnetic Field Observations of Upstream Ultra-Low Frequency Waves at Mercury

NASA Technical Reports Server (NTRS)

Le, G.; Chi, P. J.; Boardsen, S.; Blanco-Cano, X.; Anderosn, B. J.; Korth, H.

2012-01-01

The region upstream from a planetary bow shock is a natural plasma laboratory containing a variety of wave particle phenomena. The study of foreshocks other than the Earth's is important for extending our understanding of collisionless shocks and foreshock physics since the bow shock strength varies with heliocentric distance from the Sun, and the sizes of the bow shocks are different at different planets. The Mercury's bow shock is unique in our solar system as it is produced by low Mach number solar wind blowing over a small magnetized body with a predominately radial interplanetary magnetic field. Previous observations of Mercury upstream ultra-low frequency (ULF) waves came exclusively from two Mercury flybys of Mariner 10. The MESSENGER orbiter data enable us to study of upstream waves in the Mercury's foreshock in depth. This paper reports an overview of upstream ULF waves in the Mercury's foreshock using high-time resolution magnetic field data, 20 samples per second, from the MESSENGER spacecraft. The most common foreshock waves have frequencies near 2 Hz, with properties similar to the I-Hz waves in the Earth's foreshock. They are present in both the flyby data and in every orbit of the orbital data we have surveyed. The most common wave phenomenon in the Earth's foreshock is the large-amplitude 30-s waves, but similar waves at Mercury have frequencies at near 0.1 Hz and occur only sporadically with short durations (a few wave cycles). Superposed on the "30-s" waves, there are spectral peaks at near 0.6 Hz, not reported previously in Mariner 10 data. We will discuss wave properties and their occurrence characteristics in this paper.

Design and fabrication of hybrid SPP waveguides for ultrahigh-bandwidth low-penalty terabit-scale data transmission.

PubMed

Du, Jing; Wang, Jian

2017-11-27

Here we design and fabricate a hybrid surface plasmon polarities (SPP) waveguide on the silicon-on-insulator (SOI) photonics platform. The designed hybrid SPP waveguide is composed of a metal ridge, an air gap, and a silicon ridge. We simulate the mode characteristics in the structure and design the waveguide with a wide air gap that can simplify the fabrication process and maintain the advantages of the hybrid SPP mode. The performance of ultrahigh-bandwidth data transmission through the proposed waveguide is then investigated using 161 wavelength-division multiplexing (WDM) channels, each carrying a 11.2-Gbit/s orthogonal frequency-division multiplexing (OFDM) 16-ary quadrature amplitude modulation (16-QAM) signal. The bit-error rates (BERs) of all 161 channels are less than 1e-3. The favorable results show the prospect of on-chip optical interconnection using the proposed hybrid SPP waveguide.

Assessment of occupational exposure to extremely low frequency magnetic fields in hospital personnel.

PubMed

Úbeda, Alejandro; Martínez, María Antonia; Cid, María Antonia; Chacón, Lucía; Trillo, María A; Leal, Jocelyne

2011-07-01

It has been proposed that chronic exposure to extremely low frequency (ELF) magnetic fields (MF) in occupational environments could represent a risk factor for a number of disorders. Medical and technical workers in hospitals have been reported to be exposed to relatively strong ELF fields. The present work aims to characterize exposure to MF in the 5 Hz to 2 kHz frequency range in a large hospital through both instantaneous environmental measurements and personal monitoring of workers. The study was conducted in different working environments of a hospital with about 4400 employees, many of them working at two or more different work stations and consequently, exposed to MF levels that were expected to be unevenly distributed in space and time. The results indicate that: (1) The dominant frequency at the studied environments was 50 Hz (average 90.8 ± 6% of the total B value); (2) The best descriptive information on a worker's exposure is obtained from personal monitoring of volunteer workers; (3) The arithmetic averages of exposure levels obtained from the monitoring ranged from 0.03 ± 0.01 µT in nurses to 0.39 ± 0.13 µT in physiotherapists; and (4) The description of the MF environment through spot measurements in the workplace, although coherent with the data from personal monitoring, might not adequately estimate MF exposure in some professional categories. Copyright © 2011 Wiley-Liss, Inc.

Frequency-dependent response of SI RA-class neurons to vibrotactile stimulation of the receptive field.

PubMed

Whitsel, B L; Kelly, E F; Xu, M; Tommerdahl, M; Quibrera, M

2001-01-01

Three types of experiment were carried out on anesthetized monkeys and cats. In the first, spike discharge activity of rapidly adapting (RA) SI neurons was recorded extracellularly during the application of different frequencies of vibrotactile stimulation to the receptive field (RF). The second used the same stimulus conditions to study the response of RA-I (RA) cutaneous mechanoreceptive afferents. The third used optical intrinsic signal (OIS) imaging and extracellular neurophysiological recording methods together, in the same sessions, to evaluate the relationship between the SI optical and RA neuron spike train responses to low- vs high-frequency stimulation of the same skin site. RA afferent entrainment was high at all frequencies of stimulation. In contrast, SI RA neuron entrainment was much lower on average, and was strongly frequency-dependent, declining in near-linear fashion from 6 to 200 Hz. Even at 200 Hz, however, unambiguous frequency-following responses were present in the spike train activity of som

Sterilization of liquid foods by pulsed electric fields–an innovative ultra-high temperature process

PubMed Central

Reineke, Kai; Schottroff, Felix; Meneses, Nicolas; Knorr, Dietrich

2015-01-01

The intention of this study was to investigate the inactivation of endospores by a combined thermal and pulsed electric field (PEF) treatment. Therefore, self-cultivated spores of Bacillus subtilis and commercial Geobacillus stearothermophilus spores with certified heat resistance were utilized. Spores of both strains were suspended in saline water (5.3 mS cm−1), skim milk (0.3% fat; 5.3 mS cm−1) and fresh prepared carrot juice (7.73 mS cm−1). The combination of moderate preheating (70–90°C) and an insulated PEF-chamber, combined with a holding tube (65 cm) and a heat exchanger for cooling, enabled a rapid heat up to 105–140°C (measured above the PEF chamber) within 92.2–368.9 μs. To compare the PEF process with a pure thermal inactivation, each spore suspension was heat treated in thin glass capillaries and D-values from 90 to 130°C and its corresponding z-values were calculated. For a comparison of the inactivation data, F-values for the temperature fields of both processes were calculated by using computational fluid dynamics (CFD). A preheating of saline water to 70°C with a flow rate of 5 l h−1, a frequency of 150 Hz and an energy input of 226.5 kJ kg−1, resulted in a measured outlet temperature of 117°C and a 4.67 log10 inactivation of B. subtilis. The thermal process with identical F-value caused only a 3.71 log10 inactivation. This synergism of moderate preheating and PEF was even more pronounced for G. stearothermophilus spores in saline water. A preheating to 95°C and an energy input of 144 kJ kg−1 resulted in an outlet temperature of 126°C and a 3.28 log10 inactivation, whereas nearly no inactivation (0.2 log10) was achieved during the thermal treatment. Hence, the PEF technology was evaluated as an alternative ultra-high temperature process. However, for an industrial scale application of this process for sterilization, optimization of the treatment chamber design is needed to reduce the occurring inhomogeneous temperature

Structural Analysis of Titan's Tholins by Ultra-High Resolution Mass Spectrometry

NASA Astrophysics Data System (ADS)

Vuitton, V.; Frisari, M.; Thissen, R.; Dutuit, O.; Bonnet, J.-Y.; Quirico, E.; Sciamma O'Brien, E.; Szopa, C.; Carrasco, N.; Somogyi, A.; Smith, M.; Hörst, S. M.; Yelle, R.

2010-04-01

We propose here a systematic ultra-high resolution mass spectrometry and MS/MS study in order to provide a more coherent and complete characterization of the structure of the molecules making up the soluble fraction of the Titan tholins.

Caveats when Analyzing Ultra-high Molar Mass Polymers by SEC

USDA-ARS?s Scientific Manuscript database

The analysis of ultra-high molar mass (M > 1 million g/mol) polymers via size-exclusion chromatography (SEC) presents a number of non-trivial challenges. Dissolution and full solvation may take days, as is the case for cellulose dissolution in non-complexing non degrading solvents; very low concent...

Super-achromatic microprobe for ultrahigh-resolution endoscopic OCT imaging at 800 nm (Conference Presentation)

NASA Astrophysics Data System (ADS)

Yuan, Wu; Alemohammad, Milad; Yu, Xiaoyun; Yu, Shaoyong; Li, Xingde

2016-03-01

In this paper, we report a super-achromatic microprobe made with fiber-optic ball lens to enable ultrahigh-resolution endoscopic OCT imaging. An axial resolution of ~2.4 µm (in air) can be achieved with a 7-fs Ti:Sapphire laser. The microprobe has minimal astigmatism which affords a high transverse resolution of ~5.6 µm. The miniaturized microprobe has an outer diameter of ~520 µm including the encasing metal guard and can be used to image small luminal organs. The performance of the ultrahigh-resolution OCT microprobe was demonstrated by imaging rat esophagus, guinea pig esophagus, and mouse rectum in vivo.

Precision requirements and innovative manufacturing for ultrahigh precision laser interferometry of gravitational-wave astronomy

NASA Astrophysics Data System (ADS)

Ni, Wei-Tou; Han, Sen; Jin, Tao

2016-11-01

With the LIGO announcement of the first direct detection of gravitational waves (GWs), the GW Astronomy was formally ushered into our age. After one-hundred years of theoretical investigation and fifty years of experimental endeavor, this is a historical landmark not just for physics and astronomy, but also for industry and manufacturing. The challenge and opportunity for industry is precision and innovative manufacturing in large size - production of large and homogeneous optical components, optical diagnosis of large components, high reflectance dielectric coating on large mirrors, manufacturing of components for ultrahigh vacuum of large volume, manufacturing of high attenuating vibration isolation system, production of high-power high-stability single-frequency lasers, production of high-resolution positioning systems etc. In this talk, we address the requirements and methods to satisfy these requirements. Optical diagnosis of large optical components requires large phase-shifting interferometer; the 1.06 μm Phase Shifting Interferometer for testing LIGO optics and the recently built 24" phase-shifting Interferometer in Chengdu, China are examples. High quality mirrors are crucial for laser interferometric GW detection, so as for ring laser gyroscope, high precision laser stabilization via optical cavities, quantum optomechanics, cavity quantum electrodynamics and vacuum birefringence measurement. There are stringent requirements on the substrate materials and coating methods. For cryogenic GW interferometer, appropriate coating on sapphire or silicon are required for good thermal and homogeneity properties. Large ultrahigh vacuum components and high attenuating vibration system together with an efficient metrology system are required and will be addressed. For space interferometry, drag-free technology and weak-light manipulation technology are must. Drag-free technology is well-developed. Weak-light phase locking is demonstrated in the laboratories while

Understanding and manipulating the RF fields at high field MRI

PubMed Central

Ibrahim, Tamer S.; Hue, YiK-Kiong; Tang, Lin

2015-01-01

This paper presents a complete overview of the electromagnetics (radiofrequency aspect) of MRI at low and high fields. Using analytical formulations, numerical modeling (computational electromagnetics), and ultrahigh field imaging experiments, the physics that impacts the electromagnetic quantities associated with MRI, namely (1) the transmit field, (2) receive field, and (3) total electromagnetic power absorption, is analyzed. The physical interpretation of the above-mentioned quantities is investigated by electromagnetic theory, to understand ‘What happens, in terms of electromagnetics, when operating at different static field strengths?’ Using experimental studies and numerical simulations, this paper also examines the physical and technological feasibilities by which all or any of these specified electromagnetic quantities can be manipulated through techniques such as B1 shimming (phased array excitation) and signal combination using a receive array in order to advance MRI at high field strengths. Pertinent to this subject and with highly coupled coils operating at 7 T, this paper also presents the first phantom work on B1 shimming without B1 measurements. PMID:19621335

On the Power Dependence of Extraneous Microwave Fields in Atomic Frequency Standards

DTIC Science & Technology

2005-01-01

uncertainty”, Metrologia 35 (1998) pp. 829-845. [6] K. Dorenwendt and A. Bauch, “Spurious Microwave Fields in Caesium Atomic Beam Standards...Cesium Beam Clocks Induced by Microwave Leakages”, IEEE Trans. UFFC 45 (1998)728-738. [8] M. Abgrall, “Evaluation des Performances de la Fontaine...Proc of the EFTF 2005 – in press. [12] A. DeMarchi, “The Optically Pumped Caesium Fountain: 10-15 Frequency Accuracy?”, Metrologia 18 (1982) pp

FieldSpec: A field portable mass spectrometer prototype for high frequency measurements of δ (2) H and δ (18) O ratios in water

NASA Astrophysics Data System (ADS)

López Días, Veneranda; Quang Hoang, Hung; Martínez-Carreras, Núria; Barnich, François; Wirtz, Tom; Pfister, Laurent; McDonnell, Jeffrey

2016-04-01

Hydrological studies relying on stable water isotopes to better understand water sources, flowpaths and transit times are currently limited by the coarse temporal resolution of sampling and analysis protocols. At present, two kinds of lab-based instruments are used : (i) the standard isotope ratio mass spectrometers (IRMS) [1] and (ii) the laser-based instruments [2, 3]. In both cases, samples need to be collected in the field and then transferred to the laboratory for the water isotopic ratio measurements (even further complex sample preparation is required for the IRMS). Hence, past and ongoing research targets the development of field deployable instruments for measuring stable water isotopes at high temporal frequencies. While recent studies have demonstrated that laser-based instruments may be taken to the field [4, 5], their size and power consumption still restrict their use to sites equipped with mains power or generators. Here, we present progress on the development of a field portable mass spectrometer (FieldSpec) for direct high frequency measurements of δ2H and δ18O ratios in water. The FieldSpec instrument is based upon the use of a double focusing magnetic sector mass spectrometer in combination with an electron impact ion source and a membrane dual inlet system. The instrument directly collects liquid water samples in the field, which are then converted into water vapour before being injected into the mass spectrometer for the stable isotope analysis. δ2H and δ18O are derived from the measured mass spectra. All the components are arranged in a vacuum case having a suit case type dimension with portable electronics and battery. Proof-of-concept experiments have been carried out to characterize the instrument. The results show that the FieldSpec instrument has good linearity (R2 = 0.99). The reproducibility of the instrument ranges between 1 and 4 ‰ for δ2H and between 0.1 and 0.4 ‰ for δ18O isotopic ratio measurements. A measurement

Electromagnetic Processing as a Way of Increasing Microbiological Safety of Animal Waste

NASA Astrophysics Data System (ADS)

Soboleva, O. M.; Kolosova, M. M.; Filipovich, L. A.; Aksenov, V. A.

2017-05-01

The article shows the possibility of using the electromagnetic field of ultrahigh frequency (EMF UHF) for drying and disinfecting of such animal waste as pig manure and poultry droppings. The studied modes included the following options: processing exposure of 60, 90, 120 sec, the capacity of 60 kW, the frequency of 915 MHz. The method of UHF processing of manure and poultry droppings is environmentally safe and effective in neutralizing the pathogenic microflora, as well as larvae and eggs of worms. The following processing mode of animal waste in the electromagnetic field of ultrahigh frequency was recognized as optimal: exposure of 90 seconds, the capacity of 60 kW, the frequency of 915 MHz. This option leads to the complete destruction of pathogenic and conditionally pathogenic microorganisms, as well as the eggs and larvae of worms. As a result of this processing, a high level of microbiological safety of pig manure and poultry droppings is achieved that allows using them as organic fertilizers. The peculiarities of some species of pathogenic fungi developing on the surface of the wheat grain are shown. Pre-processed animal waste (pig manure and and poultry droppings) were applied in experimental variants. Used organic fertilizers underwent electromagnetic processing of ultra-high frequency. The qualitative composition of the microflora on the surface of the grain depends on the type of animal waste (manure or droppings) and used dose. The safest part of the microflora of grain was marked with the application of the UHF-processed pig manure and poultry droppings in doses of 10 t/ha.

Successful Cleaning and Study of Contamination of Si(001) in Ultrahigh Vacuum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gheorghe, N. G.; Lungu, G. A.; Husanu, M. A.

2011-10-03

This paper presents the very first surface physics experiment performed in ultrahigh vacuum (UHV) in Romania, using a new molecular beam epitaxy (MBE) installation. Cleaning of a Si(001) wafer was achieved by using a very simple technique: sequences of annealing at 900-1000 deg. C in ultrahigh vacuum: low 10{sup -8} mbar, with a base pressure of 1.5x10{sup -10} mbar. The preparation procedure is quite reproducible and allows repeated cleaning of the Si(001) after contamination in ultrahigh vacuum. The Si(001) single crystal surface is characterized by low energy electron diffraction (LEED), reflection high energy electron diffraction (RHEED), and Auger electron spectroscopymore » (AES). The latter technique is utilized in order to investigate the sample contamination by the residual gas in the UHV chamber, as determined by a residual gas analyzer (RGA). Unambiguous assignment of oxidized and unoxidized silicon is provided; also, an important feature is that the LVV Auger peak at 90-92 eV cannot be solely attributed to clean Si (i.e. Si surrounded only by Si), but also to silicon atoms bounded with carbon. Even with a sum of partial pressures of oxygen and carbon containing molecules in the range of 5x10{sup -10} mbar, the sample is contaminated very quickly, having a (1/e) lifetime of about 76 minutes.« less

Effects of the ultra-high pressure on structure and α-glucosidase inhibition of polysaccharide from Astragalus.

PubMed

Zhu, Zhen-Yuan; Luo, You; Dong, Guo-Ling; Ren, Yuan-Yuan; Chen, Li-Jing; Guo, Ming-Zhu; Wang, Xiao-Ting; Yang, Xue-Ying; Zhang, Yongmin

2016-06-01

A novel homogeneous polysaccharide fraction (APS) was extracted from Astragalus by hot water and purified by Sephadex G-100 and G-75 column. Its molecular weight was 693kDa. APS and APS with ultra-high pressure treatment exhibited significant inhibitory abilities on a-glucosidase, inhibition rate from high to low in order was 400MPa-APS, 300MPa-APS, 500MPa-APS and APS. The inhibition ​percentage of 400MPa-APS (1.5mg/mL) was 49% (max.). This suggested that the inhibitory activity of APS on a-glucosidase was improved by ultra-high pressure treatment. FT-IR, SEM, CD spectra, atomic force microscope and Congo red test analysis of APS and 400MPa-APS showed ultra-high pressure treatment didn't change the preliminary structure but had an effect on its advanced structure. Copyright © 2016 Elsevier B.V. All rights reserved.

Field-scale comparison of frequency- and time-domain spectral induced polarization

NASA Astrophysics Data System (ADS)

Maurya, P. K.; Fiandaca, G.; Christiansen, A. V.; Auken, E.

2018-05-01

In this paper we present a comparison study of the time-domain (TD) and frequency-domain (FD) spectral induced polarization (IP) methods in terms of acquisition time, data quality, and spectral information retrieved from inversion. We collected TDIP and FDIP surface measurements on three profiles with identical electrode setups, at two different field sites with different lithology. In addition, TDIP data were collected in two boreholes using the El-Log drilling technique, in which apparent formation resistivity and chargeability values are measured during drilling using electrodes integrated within the stem auger.

High-frequency measurements of aeolian saltation flux: Field-based methodology and applications

NASA Astrophysics Data System (ADS)

Martin, Raleigh L.; Kok, Jasper F.; Hugenholtz, Chris H.; Barchyn, Thomas E.; Chamecki, Marcelo; Ellis, Jean T.

2018-02-01

Aeolian transport of sand and dust is driven by turbulent winds that fluctuate over a broad range of temporal and spatial scales. However, commonly used aeolian transport models do not explicitly account for such fluctuations, likely contributing to substantial discrepancies between models and measurements. Underlying this problem is the absence of accurate sand flux measurements at the short time scales at which wind speed fluctuates. Here, we draw on extensive field measurements of aeolian saltation to develop a methodology for generating high-frequency (up to 25 Hz) time series of total (vertically-integrated) saltation flux, namely by calibrating high-frequency (HF) particle counts to low-frequency (LF) flux measurements. The methodology follows four steps: (1) fit exponential curves to vertical profiles of saltation flux from LF saltation traps, (2) determine empirical calibration factors through comparison of LF exponential fits to HF number counts over concurrent time intervals, (3) apply these calibration factors to subsamples of the saltation count time series to obtain HF height-specific saltation fluxes, and (4) aggregate the calibrated HF height-specific saltation fluxes into estimates of total saltation fluxes. When coupled to high-frequency measurements of wind velocity, this methodology offers new opportunities for understanding how aeolian saltation dynamics respond to variability in driving winds over time scales from tens of milliseconds to days.

Simultaneous structural and environmental loading of an ultra-high performance concrete component

DOT National Transportation Integrated Search

2010-07-01

Ultra-high performance concrete (UHPC) is an advanced cementitious composite material which tends to exhibit superior properties such as increased durability, strength, and long-term stability. This experimental investigation focused on the flexural ...

The Effects of Magnetic Exposure on the Nervous System: A study on the effects of low-strength low-frequency magnetic fields on neurotransmitter exocytosis and cell viability through ionic cyclotron resonance frequency

NASA Astrophysics Data System (ADS)

Saveriades, George

This PhD dissertation focuses on the study of the effects of magnetic exposure on biological systems using amperometry techniques and viability assays. In our prior work based on the cyclotron resonance model, chromaffin cells in physiological saline and Ca2+-free media were exposed for 5 minutes to a 2.7 muT magnetic field, with frequency sweeps going from 30-60 Hz (targeting several ions involved in exocytosis) and 44-48 Hz (targeting specifically Ca2+ ions), with noticeable effects on exocytosis. The present study extended the work on chromaffin cells by covering frequency sweeps for different ions, manipulating the time of exposure and the strength of the magnetic field. Furthermore, amperometry was conducted on acute coronal brain slices, to demonstrate that the recorded effects could be measured on neuronal tissue. The viability of chromaffin cells and primary neuronal cultures exposed to magnetic fields was also addressed. The results demonstrate that cellular exocytosis is sensitive to the frequency of the magnetic field it is exposed to, the strength of the magnetic field and the duration of exposure. No significant effects were established with regards to the viability of the cells exposed to magnetic fields.

Ultrahigh Energy Cosmic Rays: Old Physics or New Physics?

NASA Technical Reports Server (NTRS)

Stecker, F. W.

2004-01-01

We consider the advantages of and the problems associated with hypotheses to explain the origin of ultrahigh energy cosmic rays (UHECR: E greater than 10 EeV) and the "trans-GZK" cosmic rays (TGZK: E greater than 100 EeV) both through "old physics" (acceleration in cosmic sources) and "new physics" (new particles, topological defects, fat neutrino cross sections, Lorentz invariance violation).

Adaptive sensor-based ultra-high accuracy solar concentrator tracker

NASA Astrophysics Data System (ADS)

Brinkley, Jordyn; Hassanzadeh, Ali

2017-09-01

Conventional solar trackers use information of the sun's position, either by direct sensing or by GPS. Our method uses the shading of the receiver. This, coupled with nonimaging optics design allows us to achieve ultra-high concentration. Incorporating a sensor based shadow tracking method with a two stage concentration solar hybrid parabolic trough allows the system to maintain high concentration with acute accuracy.

Large-signal model of the bilayer graphene field-effect transistor targeting radio-frequency applications: Theory versus experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasadas, Francisco, E-mail: Francisco.Pasadas@uab.cat; Jiménez, David

2015-12-28

Bilayer graphene is a promising material for radio-frequency transistors because its energy gap might result in a better current saturation than the monolayer graphene. Because the great deal of interest in this technology, especially for flexible radio-frequency applications, gaining control of it requires the formulation of appropriate models for the drain current, charge, and capacitance. In this work, we have developed them for a dual-gated bilayer graphene field-effect transistor. A drift-diffusion mechanism for the carrier transport has been considered coupled with an appropriate field-effect model taking into account the electronic properties of the bilayer graphene. Extrinsic resistances have been includedmore » considering the formation of a Schottky barrier at the metal-bilayer graphene interface. The proposed model has been benchmarked against experimental prototype transistors, discussing the main figures of merit targeting radio-frequency applications.« less

Validation of the activity expansion method with ultrahigh pressure shock equations of state

NASA Astrophysics Data System (ADS)

Rogers, Forrest J.; Young, David A.

1997-11-01

Laser shock experiments have recently been used to measure the equation of state (EOS) of matter in the ultrahigh pressure region between condensed matter and a weakly coupled plasma. Some ultrahigh pressure data from nuclear-generated shocks are also available. Matter at these conditions has proven very difficult to treat theoretically. The many-body activity expansion method (ACTEX) has been used for some time to calculate EOS and opacity data in this region, for use in modeling inertial confinement fusion and stellar interior plasmas. In the present work, we carry out a detailed comparison with the available experimental data in order to validate the method. The agreement is good, showing that ACTEX adequately describes strongly shocked matter.

Two-spoke placement optimization under explicit specific absorption rate and power constraints in parallel transmission at ultra-high field.

PubMed

Dupas, Laura; Massire, Aurélien; Amadon, Alexis; Vignaud, Alexandre; Boulant, Nicolas

2015-06-01

The spokes method combined with parallel transmission is a promising technique to mitigate the B1(+) inhomogeneity at ultra-high field in 2D imaging. To date however, the spokes placement optimization combined with the magnitude least squares pulse design has never been done in direct conjunction with the explicit Specific Absorption Rate (SAR) and hardware constraints. In this work, the joint optimization of 2-spoke trajectories and RF subpulse weights is performed under these constraints explicitly and in the small tip angle regime. The problem is first considerably simplified by making the observation that only the vector between the 2 spokes is relevant in the magnitude least squares cost-function, thereby reducing the size of the parameter space and allowing a more exhaustive search. The algorithm starts from a set of initial k-space candidates and performs in parallel for all of them optimizations of the RF subpulse weights and the k-space locations simultaneously, under explicit SAR and power constraints, using an active-set algorithm. The dimensionality of the spoke placement parameter space being low, the RF pulse performance is computed for every location in k-space to study the robustness of the proposed approach with respect to initialization, by looking at the probability to converge towards a possible global minimum. Moreover, the optimization of the spoke placement is repeated with an increased pulse bandwidth in order to investigate the impact of the constraints on the result. Bloch simulations and in vivo T2(∗)-weighted images acquired at 7 T validate the approach. The algorithm returns simulated normalized root mean square errors systematically smaller than 5% in 10 s. Copyright © 2015 Elsevier Inc. All rights reserved.

The Role of Ultrahigh Resolution Fourier Transform Mass Spectrometry (FT-MS) in Astrobiology-Related Research: Analysis of Meteorites and Tholins

PubMed Central

Somogyi, Árpád; Thissen, Roland; Orthous-Daunay, Francois-Régis; Vuitton, Véronique

2016-01-01

It is an important but also a challenging analytical problem to understand the chemical composition and structure of prebiotic organic matter that is present in extraterrestrial materials. Its formation, evolution and content in the building blocks (“seeds”) for more complex molecules, such as proteins and DNA, are key questions in the field of exobiology. Ultrahigh resolution mass spectrometry is one of the best analytical techniques that can be applied because it provides reliable information on the chemical composition and structure of individual components of complex organic mixtures. Prebiotic organic material is delivered to Earth by meteorites or generated in laboratories in simulation (model) experiments that mimic space or atmospheric conditions. Recent representative examples for ultrahigh resolution mass spectrometry studies using Fourier-transform (FT) mass spectrometers such as Orbitrap and ion cyclotron resonance (ICR) mass spectrometers are shown and discussed in the present article, including: (i) the analysis of organic matter of meteorites; (ii) modeling atmospheric processes in ICR cells; and (iii) the structural analysis of laboratory made tholins that might be present in the atmosphere and surface of Saturn’s largest moon, Titan. PMID:27023520

Seizure entrainment with polarizing low frequency electric fields in a chronic animal epilepsy model

PubMed Central

Sunderam, Sridhar; Chernyy, Nick; Peixoto, Nathalia; Mason, Jonathan P.; Weinstein, Steven L.; Schiff, Steven J.; Gluckman, Bruce J.

2009-01-01