Sample records for ultrashort infrared laser

  1. Optical reprogramming of human somatic cells using ultrashort Bessel-shaped near-infrared femtosecond laser pulses

    NASA Astrophysics Data System (ADS)

    Uchugonova, Aisada; Breunig, Hans Georg; Batista, Ana; König, Karsten

    2015-11-01

    We report a virus-free optical approach to human cell reprogramming into induced pluripotent stem cells with low-power nanoporation using ultrashort Bessel-shaped laser pulses. Picojoule near-infrared sub-20 fs laser pulses at a high 85 MHz repetition frequency are employed to generate transient nanopores in the membrane of dermal fibroblasts for the introduction of four transcription factors to induce the reprogramming process. In contrast to conventional approaches which utilize retro- or lentiviruses to deliver genes or transcription factors into the host genome, the laser method is virus-free; hence, the risk of virus-induced cancer generation limiting clinical application is avoided.

  2. Mid-infrared laser filaments in the atmosphere

    PubMed Central

    Mitrofanov, A. V.; Voronin, A. A.; Sidorov-Biryukov, D. A.; Pugžlys, A.; Stepanov, E. A.; Andriukaitis, G.; Flöry, T.; Ališauskas, S.; Fedotov, A. B.; Baltuška, A.; Zheltikov, A. M.

    2015-01-01

    Filamentation of ultrashort laser pulses in the atmosphere offers unique opportunities for long-range transmission of high-power laser radiation and standoff detection. With the critical power of self-focusing scaling as the laser wavelength squared, the quest for longer-wavelength drivers, which would radically increase the peak power and, hence, the laser energy in a single filament, has been ongoing over two decades, during which time the available laser sources limited filamentation experiments in the atmosphere to the near-infrared and visible ranges. Here, we demonstrate filamentation of ultrashort mid-infrared pulses in the atmosphere for the first time. We show that, with the spectrum of a femtosecond laser driver centered at 3.9 μm, right at the edge of the atmospheric transmission window, radiation energies above 20 mJ and peak powers in excess of 200 GW can be transmitted through the atmosphere in a single filament. Our studies reveal unique properties of mid-infrared filaments, where the generation of powerful mid-infrared supercontinuum is accompanied by unusual scenarios of optical harmonic generation, giving rise to remarkably broad radiation spectra, stretching from the visible to the mid-infrared. PMID:25687621

  3. Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

    NASA Astrophysics Data System (ADS)

    Tsen, K. T.; Tsen, Shaw-Wei D.; Fu, Q.; Lindsay, S. M.; Kibler, K.; Jacobs, B.; Wu, T. C.; Li, Zhe; Yan, Hao; Cope, Stephanie; Vaiana, Sara; Kiang, Juliann G.

    2010-02-01

    We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

  4. Multifunctional gold nanorods for selective plasmonic photothermal therapy in pancreatic cancer cells using ultra-short pulse near-infrared laser irradiation.

    PubMed

    Patino, Tania; Mahajan, Ujjwal; Palankar, Raghavendra; Medvedev, Nikolay; Walowski, Jakob; Münzenberg, Markus; Mayerle, Julia; Delcea, Mihaela

    2015-03-12

    Gold nanorods (AuNRs) have attracted considerable attention in plasmonic photothermal therapy for cancer treatment by exploiting their selective and localized heating effect due to their unique photophysical properties. Here we describe a strategy to design a novel multifunctional platform based on AuNRs to: (i) specifically target the adenocarcinoma MUC-1 marker through the use of the EPPT-1 peptide, (ii) enhance cellular uptake through a myristoylated polyarginine peptide (MPAP) and (iii) selectively induce cell death by ultra-short near infrared laser pulses. We used a biotin-avidin based approach to conjugate EPPT-1 and MPAP to AuNRs. Dual-peptide (EPPT-1+MPAP) labelled AuNRs showed a significantly higher uptake by pancreatic ductal adenocarcinoma cells when compared to their single peptide or avidin conjugated counterparts. In addition, we selectively induced cell death by ultra-short near infrared laser pulses in small target volumes (∼1 μm3), through the creation of plasmonic nanobubbles that lead to the destruction of a local cell environment. Our approach opens new avenues for conjugation of multiple ligands on AuNRs targeting cancer cells and tumors and it is relevant for plasmonic photothermal therapy.

  5. Non-destructive testing of ceramic materials using mid-infrared ultrashort-pulse laser

    NASA Astrophysics Data System (ADS)

    Sun, S. C.; Qi, Hong; An, X. Y.; Ren, Y. T.; Qiao, Y. B.; Ruan, Liming M.

    2018-04-01

    The non-destructive testing (NDT) of ceramic materials using mid-infrared ultrashort-pulse laser is investigated in this study. The discrete ordinate method is applied to solve the transient radiative transfer equation in 2D semitransparent medium and the emerging radiative intensity on boundary serves as input for the inverse analysis. The sequential quadratic programming algorithm is employed as the inverse technique to optimize objective function, in which the gradient of objective function with respect to reconstruction parameters is calculated using the adjoint model. Two reticulated porous ceramics including partially stabilized zirconia and oxide-bonded silicon carbide are tested. The retrieval results show that the main characteristics of defects such as optical properties, geometric shapes and positions can be accurately reconstructed by the present model. The proposed technique is effective and robust in NDT of ceramics even with measurement errors.

  6. Multifunctional gold nanorods for selective plasmonic photothermal therapy in pancreatic cancer cells using ultra-short pulse near-infrared laser irradiation

    NASA Astrophysics Data System (ADS)

    Patino, Tania; Mahajan, Ujjwal; Palankar, Raghavendra; Medvedev, Nikolay; Walowski, Jakob; Münzenberg, Markus; Mayerle, Julia; Delcea, Mihaela

    2015-03-01

    Gold nanorods (AuNRs) have attracted considerable attention in plasmonic photothermal therapy for cancer treatment by exploiting their selective and localized heating effect due to their unique photophysical properties. Here we describe a strategy to design a novel multifunctional platform based on AuNRs to: (i) specifically target the adenocarcinoma MUC-1 marker through the use of the EPPT-1 peptide, (ii) enhance cellular uptake through a myristoylated polyarginine peptide (MPAP) and (iii) selectively induce cell death by ultra-short near infrared laser pulses. We used a biotin-avidin based approach to conjugate EPPT-1 and MPAP to AuNRs. Dual-peptide (EPPT-1 + MPAP) labelled AuNRs showed a significantly higher uptake by pancreatic ductal adenocarcinoma cells when compared to their single peptide or avidin conjugated counterparts. In addition, we selectively induced cell death by ultra-short near infrared laser pulses in small target volumes (~1 μm3), through the creation of plasmonic nanobubbles that lead to the destruction of a local cell environment. Our approach opens new avenues for conjugation of multiple ligands on AuNRs targeting cancer cells and tumors and it is relevant for plasmonic photothermal therapy.Gold nanorods (AuNRs) have attracted considerable attention in plasmonic photothermal therapy for cancer treatment by exploiting their selective and localized heating effect due to their unique photophysical properties. Here we describe a strategy to design a novel multifunctional platform based on AuNRs to: (i) specifically target the adenocarcinoma MUC-1 marker through the use of the EPPT-1 peptide, (ii) enhance cellular uptake through a myristoylated polyarginine peptide (MPAP) and (iii) selectively induce cell death by ultra-short near infrared laser pulses. We used a biotin-avidin based approach to conjugate EPPT-1 and MPAP to AuNRs. Dual-peptide (EPPT-1 + MPAP) labelled AuNRs showed a significantly higher uptake by pancreatic ductal adenocarcinoma

  7. Laser ablation mechanism of transparent layers on semiconductors with ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Rublack, Tino; Hartnauer, Stefan; Mergner, Michael; Muchow, Markus; Seifert, Gerhard

    2011-12-01

    Transparent dielectric layers on semiconductors are used as anti-reflection coatings both for photovoltaic applications and for mid-infrared optical elements. We have shown recently that selective ablation of such layers is possible using ultrashort laser pulses at wavelengths being absorbed by the semiconductor. To get a deeper understanding of the ablation mechanism, we have done ablation experiments for different transparent materials, in particular SiO2 and SixNy on silicon, using a broad range of wavelengths ranging from UV to IR, and pulse durations between 50 and 2000 fs. The characterization of the ablated regions was done by light microscopy and atomic force microscopy (AFM). Utilizing laser wavelengths above the silicon band gap, selective ablation of the dielectric layer without noticeable damage of the opened silicon surface is possible. In contrast, ultrashort pulses (1-2 ps) at mid-infrared wavelengths already cause damage in the silicon at lower intensities than in the dielectric layer, even when a vibrational resonance (e.g. at λ = 9.26 μm for SiO2) is addressed. The physical processes behind this, on the first glance counterintuitive, observation will be discussed.

  8. Ultrashort Pulse (USP) Laser-Matter Interactions

    DTIC Science & Technology

    2013-03-05

    spectroscopy • Frequency/time transfer • High-capacity comms • Coherent LIDAR • Optical clocks • Calibration Material Science ultrashort, high...Laboratory 41 Laser -driven x-rays generation (0.1 – 10 MeV) • Scattering from a 300 MeV electron beam can Doppler shift a 1-eV energy laser ...1 Integrity  Service  Excellence Ultrashort Pulse (USP) Laser – Matter Interactions 5 MAR 2013 Dr. Riq Parra Program Officer AFOSR/RTB

  9. Laser system using ultra-short laser pulses

    DOEpatents

    Dantus, Marcos [Okemos, MI; Lozovoy, Vadim V [Okemos, MI; Comstock, Matthew [Milford, MI

    2009-10-27

    A laser system using ultrashort laser pulses is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal.

  10. Ultrashort-pulse laser generated nanoparticles of energetic materials

    DOEpatents

    Welle, Eric J [Niceville, NM; Tappan, Alexander S [Albuquerque, NM; Palmer, Jeremy A [Albuquerque, NM

    2010-08-03

    A process for generating nanoscale particles of energetic materials, such as explosive materials, using ultrashort-pulse laser irradiation. The use of ultrashort laser pulses in embodiments of this invention enables one to generate particles by laser ablation that retain the chemical identity of the starting material while avoiding ignition, deflagration, and detonation of the explosive material.

  11. 0.4-1.4 μm Visible to Near-Infrared Widely Broadened Super Continuum Generation with Er-doped Ultrashort Pulse Fiber Laser System

    NASA Astrophysics Data System (ADS)

    Nishizawa, Norihiko; Mitsuzawa, Hideyuki; Sumimura, Kazuhiko

    2009-03-01

    Visible to near-infrared widely broadened super continuum generation is demonstrated using ultrashort-pulse fiber laser system. Er-doped fiber chirped-pulse amplification system operated at 1550 nm in wavelength is used for the amplifier system, which generated ultrashort-pulse of 112 fs in FWHM with output power of 160 mW, on average. Almost pedestal free 200 fs second harmonic generation pulse is generated at 780 nm region using periodically poled LiNbO3 and conversion efficiency is as high as 37%. 0.45-1.40 μm widely broadened super continuum is generated in highly nonlinear photonic crystal fiber and spectrum flatness is within ±6 dB. All of the fiber devices are fusion spliced so that this system shows a good stability.

  12. Relativistic Electron Acceleration with Ultrashort Mid-IR Laser Pulses

    NASA Astrophysics Data System (ADS)

    Feder, Linus; Woodbury, Daniel; Shumakova, Valentina; Gollner, Claudia; Miao, Bo; Schwartz, Robert; Pugžlys, Audrius; Baltuška, Andrius; Milchberg, Howard

    2017-10-01

    We report the first results of laser plasma wakefield acceleration driven by ultrashort mid-infrared laser pulses (λ = 3.9 μm , pulsewidth 100 fs, energy <20 mJ, peak power <1 TW), which enables near- and above-critical density interactions with moderate-density gas jets. We present thresholds for electron acceleration based on critical parameters for relativistic self-focusing and target width, as well as trends in the accelerated beam profiles, charge and energy spectra which are supported by 3D particle-in-cell simulations. These results extend earlier work with sub-TW self-modulated laser wakefield acceleration using near IR drivers to the Mid-IR, and enable us to capture time-resolved images of relativistic self-focusing of the laser pulse. This work supported by DOE (DESC0010706TDD, DESC0015516); AFOSR(FA95501310044, FA95501610121); NSF(PHY1535519); DHS.

  13. Ultrashort Carbon Nanotubes That Fluoresce Brightly in the Near-Infrared.

    PubMed

    Danné, Noémie; Kim, Mijin; Godin, Antoine G; Kwon, Hyejin; Gao, Zhenghong; Wu, Xiaojian; Hartmann, Nicolai F; Doorn, Stephen K; Lounis, Brahim; Wang, YuHuang; Cognet, Laurent

    2018-06-14

    The intrinsic near-infrared photoluminescence observed in long single-walled carbon nanotubes is known to be quenched in ultrashort nanotubes due to their tiny size as compared to the exciton diffusion length in these materials (>100 nm). Here, we show that intense photoluminescence can be created in ultrashort nanotubes (∼40 nm length) upon incorporation of exciton-trapping sp 3 defect sites. Using super-resolution photoluminescence imaging at <25 nm resolution, we directly show the preferential localization of excitons at the nanotube ends, which separate by less than 40 nm and behave as independent emitters. This unexpected observation opens the possibility to synthesize fluorescent ultrashort nanotubes-a goal that has been long thought impossible-for bioimaging applications, where bright near-infrared photoluminescence and small size are highly desirable, and for quantum information science, where high quality and well-controlled near-infrared single photon emitters are needed.

  14. Acousto-optic replication of ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Yushkov, Konstantin B.; Molchanov, Vladimir Ya.; Ovchinnikov, Andrey V.; Chefonov, Oleg V.

    2017-10-01

    Precisely controlled sequences of ultrashort laser pulses are required in various scientific and engineering applications. We developed a phase-only acousto-optic pulse shaping method for replication of ultrashort laser pulses in a TW laser system. A sequence of several Fourier-transform-limited pulses is generated from a single femtosecond laser pulse by means of applying a piecewise linear phase modulation over the whole emission spectrum. Analysis demonstrates that the main factor which limits maximum delay between the pulse replicas is spectral resolution of the acousto-optic dispersive delay line used for pulse shaping. In experiments with a Cr:forsterite laser system, we obtained delays from 0.3 to 3.5 ps between two replicas of 190 fs transform-limited pulses at the central wavelength of laser emission, 1230 nm.

  15. Post-filament self-trapping of ultrashort laser pulses.

    PubMed

    Mitrofanov, A V; Voronin, A A; Sidorov-Biryukov, D A; Andriukaitis, G; Flöry, T; Pugžlys, A; Fedotov, A B; Mikhailova, J M; Panchenko, V Ya; Baltuška, A; Zheltikov, A M

    2014-08-15

    Laser filamentation is understood to be self-channeling of intense ultrashort laser pulses achieved when the self-focusing because of the Kerr nonlinearity is balanced by ionization-induced defocusing. Here, we show that, right behind the ionized region of a laser filament, ultrashort laser pulses can couple into a much longer light channel, where a stable self-guiding spatial mode is sustained by the saturable self-focusing nonlinearity. In the limiting regime of negligibly low ionization, this post-filamentation beam dynamics converges to a large-scale beam self-trapping scenario known since the pioneering work on saturable self-focusing nonlinearities.

  16. Mid-infrared beam splitter for ultrashort pulses.

    PubMed

    Somma, Carmine; Reimann, Klaus; Woerner, Michael; Kiel, Thomas; Busch, Kurt; Braun, Andreas; Matalla, Mathias; Ickert, Karina; Krüger, Olaf

    2017-08-01

    A design is presented for a beam splitter suitable for ultrashort pulses in the mid-infrared and terahertz spectral range consisting of a structured metal layer on a diamond substrate. Both the theory and experiment show that this beam splitter does not distort the temporal pulse shape.

  17. Laser-Material Interaction of Powerful Ultrashort Laser Pulses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Komashko, A

    2003-01-06

    Laser-material interaction of powerful (up to a terawatt) ultrashort (several picoseconds or shorter) laser pulses and laser-induced effects were investigated theoretically in this dissertation. Since the ultrashort laser pulse (USLP) duration time is much smaller than the characteristic time of the hydrodynamic expansion and thermal diffusion, the interaction occurs at a solid-like material density with most of the light energy absorbed in a thin surface layer. Powerful USLP creates hot, high-pressure plasma, which is quickly ejected without significant energy diffusion into the bulk of the material, Thus collateral damage is reduced. These and other features make USLPs attractive for amore » variety of applications. The purpose of this dissertation was development of the physical models and numerical tools for improvement of our understanding of the process and as an aid in optimization of the USLP applications. The study is concentrated on two types of materials - simple metals (materials like aluminum or copper) and wide-bandgap dielectrics (fused silica, water). First, key physical phenomena of the ultrashort light interaction with metals and the models needed to describe it are presented. Then, employing one-dimensional plasma hydrodynamics code enhanced with models for laser energy deposition and material properties at low and moderate temperatures, light absorption was self-consistently simulated as a function of laser wavelength, pulse energy and length, angle of incidence and polarization. Next, material response on time scales much longer than the pulse duration was studied using the hydrocode and analytical models. These studies include examination of evolution of the pressure pulses, effects of the shock waves, material ablation and removal and three-dimensional dynamics of the ablation plume. Investigation of the interaction with wide-bandgap dielectrics was stimulated by the experimental studies of the USLP surface ablation of water (water is a

  18. Ultrashort-Pulse Laser System: Theory of Operation and Operating Procedures

    DTIC Science & Technology

    1992-07-01

    Nov 89 - Jul 92 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Ultrashort-Pulse Laser System : Theory of Operation and C - F33615-88-C-0631 Operating...i ’IR~A&, D2;" T.&B [E] al uicod [] j 0 Avhi lp.bilty C: oded’ Avail i Qiv ULTRASHORT-PULSE LASER SYSTEM : THEORY OF OPERATION AND OPERATING PROCEDURES

  19. Influence of dispersion stretching of ultrashort UV laser pulse on the critical power for self-focusing

    NASA Astrophysics Data System (ADS)

    Ionin, A. A.; Mokrousova, D. V.; Piterimov, D. A.; Seleznev, L. V.; Sinitsyn, D. V.; Sunchugasheva, E. S.

    2018-04-01

    The critical power for self-focusing in air for ultrashort ultraviolet laser pulses, stretched due to dispersion from 90 to 730 fs, was experimentally measured. It was shown that the pulse duration enhancement due to its propagation in condensed media leads to an almost linear decrease in the critical power for self-focusing. It was also observed that when the pulse peak power exceeds the critical one, the maximum of linear plasma distribution along the ultraviolet laser filament does not shift in the direction opposite to the laser pulse propagation, as observed for infrared laser filaments, but remains at the geometrical focus.

  20. Fundamentals and industrial applications of ultrashort pulsed lasers at Bosch

    NASA Astrophysics Data System (ADS)

    König, Jens; Bauer, Thorsten

    2011-03-01

    Fundamental results of ablation processes of metals with ultrashort laser pulses in the far threshold fluence regime are shown and discussed. Time-resolved measurements of the plasma transmission exhibit two distinctive minima. The minima occurring within the first nanoseconds can be attributed to electrons and sublimated material emitted from the target surface, whereas the subsequent minimum after several 10 ns is due to particles and droplets after a thermal boiling process. Industrial applications of ultrashort pulsed laser micro machining in the Bosch Group are also shown with the production of exhaust gas sensors and common rail diesel systems. Since 2007, ultrashort laser pulses are used at the BOSCH plant in Bamberg for producing lambda-probes, which are made of a special ceramic layer system and can measure the exhaust gas properties faster and more accurately. This enables further reduction of emissions by optimized combustion control. Since 2009, BOSCH uses ultrashort pulsed lasers for micro-structuring the injector of common rail diesel systems. A drainage groove allows a tight system even at increased pressures up to 2000 bar. Diesel injection is thus even more reliable, powerful and environment-friendly.

  1. Monolithic hybrid optics for focusing ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Fuchs, U.

    2014-03-01

    Almost any application of ultrashort laser pulses involves focusing them in order to reach high intensities and/or small spot sizes as needed for micro-machining or Femto-LASIK. Hence, it is indispensable to be able to understand pulse front distortion caused by real world optics. Focusing causes pulse front distortion due to aberrations, dispersion and diffraction. Thus, the spatio-temporal profile of ultrashort laser is altered, which increases automatically the pulse duration and the focusing spot. Consequently, the main advantage of having ultrashort laser pulses - pulse durations way below 100 fs - can be lost in that one last step of the experimental set-up by focusing them unfavorable. Since compensating for dispersion, aberration and diffraction effects is quite complicated and not always possible, we pursue a different approach. We present a specially designed monolithic hybrid optics comprising refraction and diffraction effects for tight spatial and temporal focusing of ultrashort laser pulses. Both aims can be put into practice by having a high numerical aperture (NA = 0.35) and low internal dispersion at the same time. The focusing properties are very promising, due to a design, which provides diffraction limited focusing for 100 nm bandwidth at 780 nm center wavelength. Thus, pulses with durations as short as 10 fs can be focused without pulse front distortion. The outstanding performance of this optics is shown in theory and experimentally. Above that, such focusing optics are easily adapted to their special purpose - changing the center wavelength, achromatic bandwidth or even correcting for focusing into material is possible.

  2. Controlling Plasma Channels through Ultrashort Laser Pulse Filamentation

    NASA Astrophysics Data System (ADS)

    Ionin, Andrey; Seleznev, Leonid; Sunchugasheva, Elena

    2013-09-01

    A review of studies fulfilled at the Lebedev Institute in collaboration with the Moscow State University and Institute of Atmospheric Optics in Tomsk on influence of various characteristics of ultrashort laser pulse on plasma channels formed under its filamentation is presented. Filamentation of high-power laser pulses with wavefront controlled by a deformable mirror, with cross-sections spatially formed by various diaphragms and with different wavelengths was experimentally and numerically studied. An application of plasma channels formed due to filamentation of ultrashort laser pulse including a train of such pulses for triggering and guiding long electric discharges is discussed. The research was supported by RFBR Grants 11-02-12061-ofi-m and 11-02-01100, and EOARD Grant 097007 through ISTC Project 4073 P

  3. Nanosurgery of cells and chromosomes using near-infrared twelve-femtosecond laser pulses

    NASA Astrophysics Data System (ADS)

    Uchugonova, Aisada; Lessel, Matthias; Nietzsche, Sander; Zeitz, Christian; Jacobs, Karin; Lemke, Cornelius; König, Karsten

    2012-10-01

    Laser-assisted surgery based on multiphoton absorption of near-infrared laser light has great potential for high precision surgery at various depths within the cells and tissues. Clinical applications include refractive surgery (fs-LASIK). The non-contact laser method also supports contamination-free cell nanosurgery. In this paper we describe usage of an ultrashort femtosecond laser scanning microscope for sub-100 nm surgery of human cells and metaphase chromosomes. A mode-locked 85 MHz Ti:Sapphire laser with an M-shaped ultrabroad band spectrum (maxima: 770 nm/830 nm) and an in situ pulse duration at the target ranging from 12 fs up to 3 ps was employed. The effects of laser nanoprocessing in cells and chromosomes have been quantified by atomic force microscopy. These studies demonstrate the potential of extreme ultrashort femtosecond laser pulses at low mean milliwatt powers for sub-100 nm surgery of cells and cellular organelles.

  4. Nanosurgery of cells and chromosomes using near-infrared twelve-femtosecond laser pulses.

    PubMed

    Uchugonova, Aisada; Lessel, Matthias; Nietzsche, Sander; Zeitz, Christian; Jacobs, Karin; Lemke, Cornelius; König, Karsten

    2012-10-01

    ABSTRACT. Laser-assisted surgery based on multiphoton absorption of near-infrared laser light has great potential for high precision surgery at various depths within the cells and tissues. Clinical applications include refractive surgery (fs-LASIK). The non-contact laser method also supports contamination-free cell nanosurgery. In this paper we describe usage of an ultrashort femtosecond laser scanning microscope for sub-100 nm surgery of human cells and metaphase chromosomes. A mode-locked 85 MHz Ti:Sapphire laser with an M-shaped ultrabroad band spectrum (maxima: 770  nm/830  nm) and an in situ pulse duration at the target ranging from 12 fs up to 3 ps was employed. The effects of laser nanoprocessing in cells and chromosomes have been quantified by atomic force microscopy. These studies demonstrate the potential of extreme ultrashort femtosecond laser pulses at low mean milliwatt powers for sub-100 nm surgery of cells and cellular organelles.

  5. New methods of generation of ultrashort laser pulses for ranging

    NASA Technical Reports Server (NTRS)

    Jelinkova, Helena; Hamal, Karel; Kubecek, V.; Prochazka, Ivan

    1993-01-01

    To reach the millimeter satellite laser ranging accuracy, the goal for nineties, new laser ranging techniques have to be applied. To increase the laser ranging precision, the application of the ultrashort laser pulses in connection with the new signal detection and processing techniques, is inevitable. The two wavelength laser ranging is one of the ways to measure the atmospheric dispersion to improve the existing atmospheric correction models and hence, to increase the overall system ranging accuracy to the desired value. We are presenting a review of several nonstandard techniques of ultrashort laser pulses generation, which may be utilized for laser ranging: compression of the nanosecond pulses using stimulated Brillouin and Raman backscattering; compression of the mode-locked pulses using Raman backscattering; passive mode-locking technique with nonlinear mirror; and passive mode-locking technique with the negative feedback.

  6. Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries.

    PubMed

    Santos, Moises Oliveira Dos; Latrive, Anne; De Castro, Pedro Arthur Augusto; De Rossi, Wagner; Zorn, Telma Maria Tenorio; Samad, Ricardo Elgul; Freitas, Anderson Zanardi; Cesar, Carlos Lenz; Junior, Nilson Dias Vieira; Zezell, Denise Maria

    2017-03-01

    Thousands of people die every year from burn injuries. The aim of this study is to evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns. We used an in vivo animal model and monitored the healing process using 4 different imaging modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation (SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized Wistar rats were burned by water vapor exposure and subsequently treated either by classical surgical debridement, by laser ablation, or left without treatment. Skin burn tissues were non-invasively characterized by OCT images and biopsied for further histopathology analysis, SHG imaging and FTIR spectroscopy at 3, 5, 7 and 14 days after burn. The laser protocol was found as efficient as the classical treatment for promoting the healing process. The study concludes to the validation of femtosecond ultra-short pulses laser treatment for skinburns, with the advantage of minimizing operatory trauma.

  7. Calculus removal on a root cement surface by ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Kraft, Johan F.; Vestentoft, Kasper; Christensen, Bjarke H.; Løvschall, Henrik; Balling, Peter

    2008-01-01

    Ultrashort-pulse-laser ablation of dental calculus (tartar) and cement is performed on root surfaces. The investigation shows that the threshold fluence for ablation of calculus is a factor of two to three times smaller than that of a healthy root cement surface. This indicates that ultrashort laser pulses may provide an appropriate tool for selective removal of calculus with minimal damage to the underlying root cement. Future application of an in situ profiling technique allows convenient on-line monitoring of the ablation process.

  8. Pathogen Reduction in Human Plasma Using an Ultrashort Pulsed Laser

    PubMed Central

    Tsen, Shaw-Wei D.; Kingsley, David H.; Kibler, Karen; Jacobs, Bert; Sizemore, Sara; Vaiana, Sara M.; Anderson, Jeanne; Tsen, Kong-Thon; Achilefu, Samuel

    2014-01-01

    Pathogen reduction is a viable approach to ensure the continued safety of the blood supply against emerging pathogens. However, the currently licensed pathogen reduction techniques are ineffective against non-enveloped viruses such as hepatitis A virus, and they introduce chemicals with concerns of side effects which prevent their widespread use. In this report, we demonstrate the inactivation of both enveloped and non-enveloped viruses in human plasma using a novel chemical-free method, a visible ultrashort pulsed laser. We found that laser treatment resulted in 2-log, 1-log, and 3-log reductions in human immunodeficiency virus, hepatitis A virus, and murine cytomegalovirus in human plasma, respectively. Laser-treated plasma showed ≥70% retention for most coagulation factors tested. Furthermore, laser treatment did not alter the structure of a model coagulation factor, fibrinogen. Ultrashort pulsed lasers are a promising new method for chemical-free, broad-spectrum pathogen reduction in human plasma. PMID:25372037

  9. Effect of pulse temporal shape on optical trapping and impulse transfer using ultrashort pulsed lasers.

    PubMed

    Shane, Janelle C; Mazilu, Michael; Lee, Woei Ming; Dholakia, Kishan

    2010-03-29

    We investigate the effects of pulse duration on optical trapping with high repetition rate ultrashort pulsed lasers, through Lorentz-Mie theory, numerical simulation, and experiment. Optical trapping experiments use a 12 femtosecond duration infrared pulsed laser, with the trapping microscope's temporal dispersive effects measured and corrected using the Multiphoton Intrapulse Interference Phase Scan method. We apply pulse shaping to reproducibly stretch pulse duration by 1.5 orders of magnitude and find no material-independent effects of pulse temporal profile on optical trapping of 780nm silica particles, in agreement with our theory and simulation. Using pulse shaping, we control two-photon fluorescence in trapped fluorescent particles, opening the door to other coherent control applications with trapped particles.

  10. Hawking radiation from ultrashort laser pulse filaments.

    PubMed

    Belgiorno, F; Cacciatori, S L; Clerici, M; Gorini, V; Ortenzi, G; Rizzi, L; Rubino, E; Sala, V G; Faccio, D

    2010-11-12

    Event horizons of astrophysical black holes and gravitational analogues have been predicted to excite the quantum vacuum and give rise to the emission of quanta, known as Hawking radiation. We experimentally create such a gravitational analogue using ultrashort laser pulse filaments and our measurements demonstrate a spontaneous emission of photons that confirms theoretical predictions.

  11. Multiphoton photoemission from a copper cathode illuminated by ultrashort laser pulses in an RF photoinjector.

    PubMed

    Musumeci, P; Cultrera, L; Ferrario, M; Filippetto, D; Gatti, G; Gutierrez, M S; Moody, J T; Moore, N; Rosenzweig, J B; Scoby, C M; Travish, G; Vicario, C

    2010-02-26

    In this Letter we report on the use of ultrashort infrared laser pulses to generate a copious amount of electrons by a copper cathode in an rf photoinjector. The charge yield verifies the generalized Fowler-Dubridge theory for multiphoton photoemission. The emission is verified to be prompt using a two pulse autocorrelation technique. The thermal emittance associated with the excess kinetic energy from the emission process is comparable with the one measured using frequency tripled uv laser pulses. In the high field of the rf gun, up to 50 pC of charge can be extracted from the cathode using a 80 fs long, 2 microJ, 800 nm pulse focused to a 140 mum rms spot size. Taking into account the efficiency of harmonic conversion, illuminating a cathode directly with ir laser pulses can be the most efficient way to employ the available laser power.

  12. Ultrashort laser pulse driven inverse free electron laser accelerator experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moody, J. T.; Anderson, S. G.; Anderson, G.

    In this paper we discuss the ultrashort pulse high gradient Inverse Free Electron laser accelerator experiment carried out at the Lawrence Livermore National Laboratory which demonstrated gra- dients exceeding 200 MV/m using a 4 TW 100 fs long 800 nm Ti:Sa laser pulse. Due to the short laser and electron pulse lengths, synchronization was determined to be one of the main challenges in this experiment. This made necessary the implementation of a single-shot, non destructive, electro-optic sampling based diagnostics to enable time-stamping of each laser accelerator shot with < 100 fs accuracy. The results of this experiment are expected tomore » pave the way towards the development of future GeV-class IFEL accelerators.« less

  13. Ultrashort laser pulse driven inverse free electron laser accelerator experiment

    DOE PAGES

    Moody, J. T.; Anderson, S. G.; Anderson, G.; ...

    2016-02-29

    In this paper we discuss the ultrashort pulse high gradient Inverse Free Electron laser accelerator experiment carried out at the Lawrence Livermore National Laboratory which demonstrated gra- dients exceeding 200 MV/m using a 4 TW 100 fs long 800 nm Ti:Sa laser pulse. Due to the short laser and electron pulse lengths, synchronization was determined to be one of the main challenges in this experiment. This made necessary the implementation of a single-shot, non destructive, electro-optic sampling based diagnostics to enable time-stamping of each laser accelerator shot with < 100 fs accuracy. The results of this experiment are expected tomore » pave the way towards the development of future GeV-class IFEL accelerators.« less

  14. Optical control of filamentation-induced damage to DNA by intense, ultrashort, near-infrared laser pulses

    PubMed Central

    Dharmadhikari, J. A.; Dharmadhikari, A. K.; Kasuba, K. C.; Bharambe, H.; D’Souza, J. S.; Rathod, K. D.; Mathur, D.

    2016-01-01

    We report on damage to DNA in an aqueous medium induced by ultrashort pulses of intense laser light of 800 nm wavelength. Focusing of such pulses, using lenses of various focal lengths, induces plasma formation within the aqueous medium. Such plasma can have a spatial extent that is far in excess of the Rayleigh range. In the case of water, the resulting ionization and dissociation gives rise to in situ generation of low-energy electrons and OH-radicals. Interactions of these with plasmid DNA produce nicks in the DNA backbone: single strand breaks (SSBs) are induced as are, at higher laser intensities, double strand breaks (DSBs). Under physiological conditions, the latter are not readily amenable to repair. Systematic quantification of SSBs and DSBs at different values of incident laser energy and under different external focusing conditions reveals that damage occurs in two distinct regimes. Numerical aperture is the experimental handle that delineates the two regimes, permitting simple optical control over the extent of DNA damage. PMID:27279565

  15. Ultrashort megaelectronvolt positron beam generation based on laser-accelerated electrons

    NASA Astrophysics Data System (ADS)

    Xu, Tongjun; Shen, Baifei; Xu, Jiancai; Li, Shun; Yu, Yong; Li, Jinfeng; Lu, Xiaoming; Wang, Cheng; Wang, Xinliang; Liang, Xiaoyan; Leng, Yuxin; Li, Ruxin; Xu, Zhizhan

    2016-03-01

    Experimental generation of ultrashort MeV positron beams with high intensity and high density using a compact laser-driven setup is reported. A high-density gas jet is employed experimentally to generate MeV electrons with high charge; thus, a charge-neutralized MeV positron beam with high density is obtained during laser-accelerated electrons irradiating high-Z solid targets. It is a novel electron-positron source for the study of laboratory astrophysics. Meanwhile, the MeV positron beam is pulsed with an ultrashort duration of tens of femtoseconds and has a high peak intensity of 7.8 × 1021 s-1, thus allows specific studies of fast kinetics in millimeter-thick materials with a high time resolution and exhibits potential for applications in positron annihilation spectroscopy.

  16. Reduction of protection from laser eyewear with ultrashort exposure

    NASA Astrophysics Data System (ADS)

    Stolarski, David J.; Stolarski, Jacob; Noojin, Gary D.; Rockwell, Benjamin A.; Thomas, Robert J.

    2001-07-01

    We have measured the optical density of various laser eye protection samples as a function of increasing irradiance. We show that the protective quality of some eyewear degrades as irradiance increases. In previous studies this problem has been demonstrated in samples irradiated by nanosecond pulses, but the current study shows that the modern laser eye protection seems to be robust except for the irradiance possible with ultrashort laser pulse exposure. We discuss the most likely saturation mechanisms in this pulse duration regime and discuss relevance to laser safety.

  17. The life cycle of infrared ultra-short high intensity laser pulses in air

    NASA Astrophysics Data System (ADS)

    Ma, Cunliang; Lin, Wenbin

    2015-08-01

    The life cycle of ultra-short high intensity laser pulses propagation in air is studied. As the controversial of the high-order Kerr indices measured by Loriot et al. [Opt. Express 18, 3011 (2010)], we focus on two models which are high-order Kerr effect included and not included. Two factors are mainly analyzed, group-velocity-dispersion and the energy evolution of the pulse. It is found that the group-velocity-dispersion can not be simply ignored even though the pulse's duration is as long as several hundreds femtoseconds. The energy loss due to the multi-photon-absorption is very small, and it may hardly change the propagation length of the pulse. Another contribution of this work is to introduce a probability quantity, which may be useful in validating the positive and negative alternating of the Kerr and high-order Kerr indices.

  18. Ultrashort laser pulses and electromagnetic pulse generation in air and on dielectric surfaces.

    PubMed

    Sprangle, P; Peñano, J R; Hafizi, B; Kapetanakos, C A

    2004-06-01

    Intense, ultrashort laser pulses propagating in the atmosphere have been observed to emit sub-THz electromagnetic pulses (EMPS). The purpose of this paper is to analyze EMP generation from the interaction of ultrashort laser pulses with air and with dielectric surfaces and to determine the efficiency of conversion of laser energy to EMP energy. In our self-consistent model the laser pulse partially ionizes the medium, forms a plasma filament, and through the ponderomotive forces associated with the laser pulse, drives plasma currents which are the source of the EMP. The propagating laser pulse evolves under the influence of diffraction, Kerr focusing, plasma defocusing, and energy depletion due to electron collisions and ionization. Collective effects and recombination processes are also included in the model. The duration of the EMP in air, at a fixed point, is found to be a few hundred femtoseconds, i.e., on the order of the laser pulse duration plus the electron collision time. For steady state laser pulse propagation the flux of EMP energy is nonradiative and axially directed. Radiative EMP energy is present only for nonsteady state or transient laser pulse propagation. The analysis also considers the generation of EMP on the surface of a dielectric on which an ultrashort laser pulse is incident. For typical laser parameters, the power and energy conversion efficiency from laser radiation to EMP radiation in both air and from dielectric surfaces is found to be extremely small, < 10(-8). Results of full-scale, self-consistent, numerical simulations of atmospheric and dielectric surface EMP generation are presented. A recent experiment on atmospheric EMP generation is also simulated.

  19. Laser Applications in Microelectronic and Optoelectronic Manufacturing IV

    DTIC Science & Technology

    1999-07-15

    laser irradiation of the clusters with 6000 laser pulses of X...insulating ma- terials during and after irradiation by tunable, ultrashort pulses from a mid-infrared laser . The three salient examples we con- sider...with ultrashort pulses re- sembles the rear-side ablation seen in irradiation of calcite by Nd:YAG lasers (1064 nm), while the off-resonance FEL

  20. Selective laser melting of hypereutectic Al-Si40-powder using ultra-short laser pulses

    NASA Astrophysics Data System (ADS)

    Ullsperger, T.; Matthäus, G.; Kaden, L.; Engelhardt, H.; Rettenmayr, M.; Risse, S.; Tünnermann, A.; Nolte, S.

    2017-12-01

    We investigate the use of ultra-short laser pulses for the selective melting of Al-Si40-powder to fabricate complex light-weight structures with wall sizes below 100 μ {m} combined with higher tensile strength and lower thermal expansion coefficient in comparison to standard Al-Si alloys. During the cooling process using conventional techniques, large primary silicon particles are formed which impairs the mechanical and thermal properties. We demonstrate that these limitations can be overcome using ultra-short laser pulses enabling the rapid heating and cooling in a non-thermal equilibrium process. We analyze the morphology characteristics and micro-structures of single tracks and thin-walled structures depending on pulse energy, repetition rate and scanning velocity utilizing pulses with a duration of 500 {fs} at a wavelength of 1030 {nm}. The possibility to specifically change and optimize the microstructure is shown.

  1. Ultrashort megaelectronvolt positron beam generation based on laser-accelerated electrons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xu, Tongjun; Shen, Baifei, E-mail: bfshen@mail.shcnc.ac.cn; Xu, Jiancai, E-mail: jcxu@siom.ac.cn

    Experimental generation of ultrashort MeV positron beams with high intensity and high density using a compact laser-driven setup is reported. A high-density gas jet is employed experimentally to generate MeV electrons with high charge; thus, a charge-neutralized MeV positron beam with high density is obtained during laser-accelerated electrons irradiating high-Z solid targets. It is a novel electron–positron source for the study of laboratory astrophysics. Meanwhile, the MeV positron beam is pulsed with an ultrashort duration of tens of femtoseconds and has a high peak intensity of 7.8 × 10{sup 21} s{sup −1}, thus allows specific studies of fast kinetics in millimeter-thick materials withmore » a high time resolution and exhibits potential for applications in positron annihilation spectroscopy.« less

  2. Critical dimension control using ultrashort laser for improving wafer critical dimension uniformity

    NASA Astrophysics Data System (ADS)

    Avizemer, Dan; Sharoni, Ofir; Oshemkov, Sergey; Cohen, Avi; Dayan, Asaf; Khurana, Ranjan; Kewley, Dave

    2015-07-01

    Requirements for control of critical dimension (CD) become more demanding as the integrated circuit (IC) feature size specifications become tighter and tighter. Critical dimension control, also known as CDC, is a well-known laser-based process in the IC industry that has proven to be robust, repeatable, and efficient in adjusting wafer CD uniformity (CDU) [Proc. SPIE 6152, 615225 (2006)]. The process involves locally and selectively attenuating the deep ultraviolet light which goes through the photomask to the wafer. The input data for the CDC process in the wafer fab is typically taken from wafer CDU data, which is measured by metrology tools such as wafer-critical dimension-scanning electron microscopy (CD-SEM), wafer optical scatterometry, or wafer level CD (WLCD). The CD correction process uses the CDU data in order to create an attenuation correction contour, which is later applied by the in-situ ultrashort laser system of the CDC to locally change the transmission of the photomask. The ultrashort pulsed laser system creates small, partially scattered, Shade-In-Elements (also known as pixels) by focusing the laser beam inside the quartz bulk of the photomask. This results in the formation of a localized, intravolume, quartz modified area, which has a different refractive index than the quartz bulk itself. The CDC process flow for improving wafer CDU in a wafer fab with detailed explanations of the shading elements formation inside the quartz by the ultrashort pulsed laser is reviewed.

  3. Surface ablation of aluminum and silicon by ultrashort laser pulses of variable width

    NASA Astrophysics Data System (ADS)

    Zayarny, D. A.; Ionin, A. A.; Kudryashov, S. I.; Makarov, S. V.; Kuchmizhak, A. A.; Vitrik, O. B.; Kulchin, Yu. N.

    2016-06-01

    Single-shot thresholds of surface ablation of aluminum and silicon via spallative ablation by infrared (IR) and visible ultrashort laser pulses of variable width τlas (0.2-12 ps) have been measured by optical microscopy. For increasing laser pulse width τlas < 3 ps, a drastic (threefold) drop of the ablation threshold of aluminum has been observed for visible pulses compared to an almost negligible threshold variation for IR pulses. In contrast, the ablation threshold in silicon increases threefold with increasing τlas for IR pulses, while the corresponding thresholds for visible pulses remained almost constant. In aluminum, such a width-dependent decrease in ablation thresholds has been related to strongly diminished temperature gradients for pulse widths exceeding the characteristic electron-phonon thermalization time. In silicon, the observed increase in ablation thresholds has been ascribed to two-photon IR excitation, while in the visible range linear absorption of the material results in almost constant thresholds.

  4. [Flexible Guidance of Ultra-Short Laser Pulses in Ophthalmic Therapy Systems].

    PubMed

    Blum, J; Blum, M; Rill, M S; Haueisen, J

    2017-01-01

    In the last 20 years, the role of ultrashort pulsed lasers in ophthalmology has become increasingly important. However, it is still impossible to guide ultra-short laser pulses with standard glass fibres. The highly energetic femtosecond pulses would destroy the fibre material, and non-linear dispersion effects would significantly change beam parameters. In contrast, photonic crystal fibres mainly guide the laser pulses in air, so that absorption and dispersive pulse broadening have essentially no effect. This article compares classical beam guidance with mirrors, lenses and prisms with photonic crystal fibres and describes the underlying concepts and the current state of technology. A classical mirror arm possesses more variable optical properties, while the HCF (Hollow-Core Photonic Crystal Fibre) must be matched in terms of the laser energy and the laser spectrum. In contrast, the HCF has more advantages in respect of handling, system integration and costs. For applications based on photodisruptive laser-tissue interaction, the relatively low damage threshold of photonic crystal fibres compared to classic beam guiding systems is unacceptable. If, however, pulsed laser radiation has a sufficiently low peak intensity, e.g. as used for plasma-induced ablation, photonic crystal fibres can definitely be considered as an alternative solution to classic beam guidance. Georg Thieme Verlag KG Stuttgart · New York.

  5. Ultra-short wavelength operation in Thulium-doped silica fiber laser with bidirectional pumping

    NASA Astrophysics Data System (ADS)

    Xiao, Xusheng; Guo, Haitao; Yan, Zhijun; Wang, Hushan; Xu, Yantao; Lu, Min; Wang, Yishan; Peng, Bo

    2017-02-01

    An ultra-short wavelength operation of Tm-doped all fiber laser based on fiber Bragg gratings (FBGs) was developed. A bi-directional pump configuration for the ultra-short wavelength operation was designed and investigated for the first time. the laser yielded 3.15W of continuous-wave output at 1706.75nm with a narrow-linewidth of 50pm and a maximum slope efficiency of 42.1%. The dependencies of the slope efficiencies and pump threshold of the laser versus the length of active fiber and reflectivity of the output mirror (FBG) were investigated in detail. An experimental comparative study between two Thulium-doped fiber lasers (TDFLs) with two different pumping configuration(forward unidirectional pumping and bidirectional pumping) was presented. It is indisputable that the development of 1.7μm silicate fiber lasers with Watt-level output power open up a number of heart-stirring and tempting application windows.

  6. Manipulation of Molecular Quantum Wavepackets with Ultrashort Laser Pulses for Non-destructive Detection of Volatile Explosives

    DTIC Science & Technology

    2013-02-01

    DTRA-TR-12-65 Manipulation of Molecular Quantum Wavepackets with Ultrashort Laser Pulses for Non-destructive Detection of Volatile Explosives ...Manipulation of Molecular Quantum Wavepackets with Ultrashort Laser Pulses for Non-destructive Detection of Volatile Explosives HDTRA1-09-1-0021 Valery...destructive detection of volatile explosives . Moshe Shapiro1, Valery Milner1 and Jun Ye2 1University of British Columbia, Vancouver, Canada 2JILA

  7. Modification of transparent materials with ultrashort laser pulses: What is energetically and mechanically meaningful?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bulgakova, Nadezhda M., E-mail: nadezhda.bulgakova@hilase.cz; Institute of Thermophysics SB RAS, 1 Lavrentyev Ave., 630090 Novosibirsk; Zhukov, Vladimir P.

    A comprehensive analysis of laser-induced modification of bulk glass by single ultrashort laser pulses is presented which is based on combination of optical Maxwell-based modeling with thermoelastoplastic simulations of post-irradiation behavior of matter. A controversial question on free electron density generated inside bulk glass by ultrashort laser pulses in modification regimes is addressed on energy balance grounds. Spatiotemporal dynamics of laser beam propagation in fused silica have been elucidated for the regimes used for direct laser writing in bulk glass. 3D thermoelastoplastic modeling of material relocation dynamics under laser-induced stresses has been performed up to the microsecond timescale when allmore » motions in the material decay. The final modification structure is found to be imprinted into material matrix already at sub-nanosecond timescale. Modeling results agree well with available experimental data on laser light transmission through the sample and the final modification structure.« less

  8. High-power ultrashort fiber laser for solar cells micromachining

    NASA Astrophysics Data System (ADS)

    Lecourt, J.-B.; Duterte, C.; Liegeois, F.; Lekime, D.; Hernandez, Y.; Giannone, D.

    2012-02-01

    We report on a high-power ultra-short fiber laser for thin film solar cells micromachining. The laser is based on Chirped Pulse Amplification (CPA) scheme. The pulses are stretched to hundreds of picoseconds prior to amplification and can be compressed down to picosecond at high energy. The repetition rate is adjustable from 100 kHz to 1 MHz and the optical average output power is close to 13 W (before compression). The whole setup is fully fibred, except the compressor achieved with bulk gratings, resulting on a compact and reliable solution for cold ablation.

  9. Pair Production Induced by Ultrashort and Ultraintense Laser Pulses in Plasmas

    NASA Astrophysics Data System (ADS)

    Luo, Yue-E.; Wang, Xue-Wen; Wang, Yuan-Sheng; Ji, Shen-Tong; Yu, Hong

    2018-06-01

    The probability of Schwinger pair production is calculated, which is induced by an ultraintense and ultrashort laser pulse propagating in a plasma. The dependence of the probability on the amplitude of the laser pulse and the frequency of plasmas is analyzed. Particularly, the effect of the pulse duration on the probability is discussed, by introducing a pulse-shape function to describe the temporal shape of the laser pulse. The results show that a laser with shorter pulse is more efficient in pair production. The probability of pair production increases when the order of the duration is comparable to the period of a laser.

  10. Precision resection of intestine using ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Beck, Rainer J.; Gora, Wojciech S.; Jayne, David; Hand, Duncan P.; Shephard, Jonathan D.

    2016-03-01

    Endoscopic resection of early colorectal neoplasms typically employs electrocautery tools, which lack precision and run the risk of full thickness thermal injury to the bowel wall with subsequent perforation. We present a means of endoluminal colonic ablation using picosecond laser pulses as a potential alternative to mitigate these limitations. High intensity ultrashort laser pulses enable nonlinear absorption processes, plasma generation, and as a consequence a predominantly non-thermal ablation regimen. Robust process parameters for the laser resection are demonstrated using fresh ex vivo pig intestine samples. Square cavities with comparable thickness to early colorectal neoplasms are removed for a wavelength of 1030 nm and 515 nm using a picosecond laser system. The corresponding histology sections exhibit in both cases only minimal collateral damage to the surrounding tissue. The ablation depth can be controlled precisely by means of the pulse energy. Overall, the application of ultrafast lasers for the resection of intestine enables significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional electrocautery.

  11. Laser mass spectrometry of chemical warfare agents using ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Weickhardt, C.; Grun, C.; Grotemeyer, J.

    1998-12-01

    Fast relaxation processes in excited molecules such as IC, ISC, and fragmentation are observed in many environmentally and technically relevant substances. They cause severe problems to resonance ionization mass spectrometry because they reduce the ionization yield and lead to mass spectra which do not allow the identification of the compound. By the use of ultrashort laser pulses these problems can be overcome and the advantages of REMPI over conventional ionization techniques in mass spectrometry can be regained. This is demonstrated using soil samples contaminated with a chemical warfare agent.

  12. Ultrashort pulse laser processing of hard tissue, dental restoration materials, and biocompatibles

    NASA Astrophysics Data System (ADS)

    Yousif, A.; Strassl, M.; Beer, F.; Verhagen, L.; Wittschier, M.; Wintner, E.

    2007-07-01

    During the last few years, ultra-short laser pulses have proven their potential for application in medical tissue treatment in many ways. In hard tissue ablation, their aptitude for material ablation with negligible collateral damage provides many advantages. Especially teeth representing an anatomically and physiologically very special region with less blood circulation and lower healing rates than other tissues require most careful treatment. Hence, overheating of the pulp and induction of microcracks are some of the most problematic issues in dental preparation. Up till now it was shown by many authors that the application of picosecond or femtosecond pulses allows to perform ablation with very low damaging potential also fitting to the physiological requirements indicated. Beside the short interaction time with the irradiated matter, scanning of the ultra-short pulse trains turned out to be crucial for ablating cavities of the required quality. One main reason for this can be seen in the fact that during scanning the time period between two subsequent pulses incident on the same spot is so much extended that no heat accumulation effects occur and each pulse can be treated as a first one with respect to its local impact. Extension of this advantageous technique to biocompatible materials, i.e. in this case dental restoration materials and titanium plasma-sprayed implants, is just a matter of consequence. Recently published results on composites fit well with earlier data on dental hard tissue. In case of plaque which has to be removed from implants, it turns out that removal of at least the calcified version is harder than tissue removal. Therefore, besides ultra-short lasers, also Diode and Neodymium lasers, in cw and pulsed modes, have been studied with respect to plaque removal and sterilization. The temperature increase during laser exposure has been experimentally evaluated in parallel.

  13. Complete wavefront and polarization control for ultrashort-pulse laser microprocessing.

    PubMed

    Allegre, O J; Jin, Y; Perrie, W; Ouyang, J; Fearon, E; Edwardson, S P; Dearden, G

    2013-09-09

    We report on new developments in wavefront and polarization control for ultrashort-pulse laser microprocessing. We use two Spatial Light Modulators in combination to structure the optical fields of a picosecond-pulse laser beam, producing vortex wavefronts and radial or azimuthal polarization states. We also carry out the first demonstration of multiple first-order beams with vortex wavefronts and radial or azimuthal polarization states, produced using Computer Generated Holograms. The beams produced are used to nano-structure a highly polished metal surface. Laser Induced Periodic Surface Structures are observed and used to directly verify the state of polarization in the focal plane and help to characterize the optical properties of the setup.

  14. Optical reprogramming with ultrashort femtosecond laser pulses

    NASA Astrophysics Data System (ADS)

    Uchugonova, Aisada; Breunig, Hans G.; Batista, Ana; König, Karsten

    2015-03-01

    The use of sub-15 femtosecond laser pulses in stem cell research is explored with particular emphasis on the optical reprogramming of somatic cells. The reprogramming of somatic cells into induced pluripotent stem (iPS) cells can be evoked through the ectopic expression of defined transcription factors. Conventional approaches utilize retro/lenti-viruses to deliver genes/transcription factors as well as to facilitate the integration of transcription factors into that of the host genome. However, the use of viruses may result in insertional mutations caused by the random integration of genes and as a result, this may limit the use within clinical applications due to the risk of the formation of cancer. In this study, a new approach is demonstrated in realizing non-viral reprogramming through the use of ultrashort laser pulses, to introduce transcription factors into the cell so as to generate iPS cells.

  15. Ablation enhancement of silicon by ultrashort double-pulse laser ablation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhao, Xin; Shin, Yung C.

    In this study, the ultrashort double-pulse ablation of silicon is investigated. An atomistic simulation model is developed to analyze the underlying physics. It is revealed that the double-pulse ablation could significantly increase the ablation rate of silicon, compared with the single pulse ablation with the same total pulse energy, which is totally different from the case of metals. In the long pulse delay range (over 1 ps), the enhancement is caused by the metallic transition of melted silicon with the corresponding absorption efficiency. At ultrashort pulse delay (below 1 ps), the enhancement is due to the electron excitation by the first pulse.more » The enhancement only occurs at low and moderate laser fluence. The ablation is suppressed at high fluence due to the strong plasma shielding effect.« less

  16. Shock ion acceleration by an ultrashort circularly polarized laser pulse via relativistic transparency in an exploded target.

    PubMed

    Kim, Young-Kuk; Cho, Myung-Hoon; Song, Hyung Seon; Kang, Teyoun; Park, Hyung Ju; Jung, Moon Youn; Hur, Min Sup

    2015-10-01

    We investigated ion acceleration by an electrostatic shock in an exploded target irradiated by an ultrashort, circularly polarized laser pulse by means of one- and three-dimensional particle-in-cell simulations. We discovered that the laser field penetrating via relativistic transparency (RT) rapidly heated the upstream electron plasma to enable the formation of a high-speed electrostatic shock. Owing to the RT-based rapid heating and the fast compression of the initial density spike by a circularly polarized pulse, a new regime of the shock ion acceleration driven by an ultrashort (20-40 fs), moderately intense (1-1.4 PW) laser pulse is envisaged. This regime enables more efficient shock ion acceleration under a limited total pulse energy than a linearly polarized pulse with crystal laser systems of λ∼1μm.

  17. Laser-Bioplasma Interaction: The Blood Type Transmutation Induced by Multiple Ultrashort Wavelength Laser Beams

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2015-11-01

    The interaction of ultrashort wavelength multi laser beams with the flowing blood thin films leads to the transmutation of the blood types A, B, and AB into O type. This is a novel mechanism of importance for the transfusion medicine. Laser radiation is in resonance with the eigen-frequency modes of the antigen proteins and forces the proteins to parametrically oscillate until they get kicked out from the surface. The stripping away of antigens is done by the scanning-multiple-lasers of a high repetition rate in the blue-purple frequency domain. The guiding-lasers are in the red-green frequency domain. The laser force, (parametric interaction with the antigen eigen-oscillation), upon the antigen protein molecule must exceed its weight. The scanning laser beam is partially reflected as long as the antigen(s) is not eliminated. The process of the protein detachment can last a few minutes. Supported by Nikola Tesla Labs., Stefan University.

  18. Control of electron excitation and localization in the dissociation of H2(+) and its isotopes using two sequential ultrashort laser pulses.

    PubMed

    He, Feng; Ruiz, Camilo; Becker, Andreas

    2007-08-24

    We study the control of dissociation of the hydrogen molecular ion and its isotopes exposed to two ultrashort laser pulses by solving the time-dependent Schrödinger equation. While the first ultraviolet pulse is used to excite the electron wave packet on the dissociative 2psigma{u} state, a second time-delayed near-infrared pulse steers the electron between the nuclei. Our results show that by adjusting the time delay between the pulses and the carrier-envelope phase of the near-infrared pulse, a high degree of control over the electron localization on one of the dissociating nuclei can be achieved (in about 85% of all fragmentation events). The results demonstrate that current (sub-)femtosecond technology can provide a control over both electron excitation and localization in the fragmentation of molecules.

  19. Multioctave infrared supercontinuum generation in large-core As₂S₃ fibers.

    PubMed

    Théberge, Francis; Thiré, Nicolas; Daigle, Jean-François; Mathieu, Pierre; Schmidt, Bruno E; Messaddeq, Younès; Vallée, Réal; Légaré, François

    2014-11-15

    We report on infrared supercontinuum (SC) generation through laser filamentation and subsequent nonlinear propagation in a step-index As2S3 fiber. The 100 μm core and high-purity As2S3 fiber used exhibit zero-dispersion wavelength around 4.5 μm, a mid-infrared background loss of 0.2  dB/m, and a maximum loss of only 0.55  dB/m at the S-H absorption peak around 4.05 μm. When pumping with ultrashort laser pulses slightly above the S-H absorption band, broadband infrared supercontinua were generated with a 20 dB spectral flatness spanning from 1.5 up to 7 μm. The efficiency and spectral shape of the SC produced by ultrashort pulses in large-core As2S3 fiber are mainly determined by its dispersion, the S-H contaminant absorption, and the mid-infrared nonlinear absorption.

  20. Photon-induced positron annihilation lifetime spectroscopy using ultrashort laser-Compton-scattered gamma-ray pulses

    NASA Astrophysics Data System (ADS)

    Taira, Y.; Toyokawa, H.; Kuroda, R.; Yamamoto, N.; Adachi, M.; Tanaka, S.; Katoh, M.

    2013-05-01

    High-energy ultrashort gamma-ray pulses can be generated via laser Compton scattering with 90° collisions at the UVSOR-II electron storage ring. As an applied study of ultrashort gamma-ray pulses, a new photon-induced positron annihilation lifetime spectroscopy approach has been developed. Ultrashort gamma-ray pulses with a maximum energy of 6.6 MeV and pulse width of 2.2 ps created positrons throughout bulk lead via pair production. Annihilation gamma rays were detected by a BaF2 scintillator mounted on a photomultiplier tube. A positron lifetime spectrum was obtained by measuring the time difference between the RF frequency of the electron storage ring and the detection time of the annihilation gamma rays. We calculated the response of the BaF2 scintillator and the time jitter caused by the variation in the total path length of the ultrashort gamma-ray pulses, annihilation gamma rays, and scintillation light using a Monte Carlo simulation code. The positron lifetime for bulk lead was successfully measured.

  1. Propagation of an ultra-short, intense laser in a relativistic fluid

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ritchie, A.B.; Decker, C.D.

    1997-12-31

    A Maxwell-relativistic fluid model is developed to describe the propagation of an ultrashort, intense laser pulse through an underdense plasma. The model makes use of numerically stabilizing fast Fourier transform (FFT) computational methods for both the Maxwell and fluid equations, and it is benchmarked against particle-in-cell (PIC) simulations. Strong fields generated in the wake of the laser are calculated, and the authors observe coherent wake-field radiation generated at harmonics of the plasma frequency due to nonlinearities in the laser-plasma interaction. For a plasma whose density is 10% of critical, the highest members of the plasma harmonic series begin to overlapmore » with the first laser harmonic, suggesting that widely used multiple-scales-theory, by which the laser and plasma frequencies are assumed to be separable, ceases to be a useful approximation.« less

  2. Generation of UV light by intense ultrashort laser pulses in air

    NASA Astrophysics Data System (ADS)

    Alexeev, Ilya; Ting, Antonio; Gordon, Daniel; Briscoe, Eldridge; Penano, Joe; Sprangle, Phillip

    2004-11-01

    The propagation of collimated high-peak-power ultrashort laser pulses in air has attracted considerable attention, which may have a variety of important applications including remote sensing and chemical-biological aerosols standoff detection. Sub-millimeter diameter laser filaments can develop without any focusing optics and instead solely from laser self-focusing and plasma formation in air. These filaments can produce ultraviolet radiations in the form of the 3rd harmonic of the fundamental frequency and also through spectral broadening due to self-phase modulation of the laser pulse. Using femtosecond laser pulses produced by a high power Ti:Sapphire laser (0.8 TW, 50 fs, 800 nm) we observed generation of the third harmonic radiation light in air (centered around 267 nm) by the laser filaments. Characterization of the 3rd harmonic generation with respect to the major gas components of the air will be reported. Supported by the ONR and RDECOM. I. Alexeev is NRC/NRL Post-Doc.

  3. Ultra-short pulse laser micro patterning with highest throughput by utilization of a novel multi-beam processing head

    NASA Astrophysics Data System (ADS)

    Homburg, Oliver; Jarczynski, Manfred; Mitra, Thomas; Brüning, Stephan

    2017-02-01

    In the last decade much improvement has been achieved for ultra-short pulse lasers with high repetition rates. This laser technology has vastly matured so that it entered a manifold of industrial applications recently compared to mainly scientific use in the past. Compared to ns-pulse ablation ultra-short pulses in the ps- or even fs regime lead to still colder ablation and further reduced heat-affected zones. This is crucial for micro patterning when structure sizes are getting smaller and requirements are getting stronger at the same time. An additional advantage of ultra-fast processing is its applicability to a large variety of materials, e.g. metals and several high bandgap materials like glass and ceramics. One challenge for ultra-fast micro machining is throughput. The operational capacity of these processes can be maximized by increasing the scan rate or the number of beams - parallel processing. This contribution focuses on process parallelism of ultra-short pulsed lasers with high repetition rate and individually addressable acousto-optical beam modulation. The core of the multi-beam generation is a smooth diffractive beam splitter component with high uniform spots and negligible loss, and a prismatic array compressor to match beam size and pitch. The optical design and the practical realization of an 8 beam processing head in combination with a high average power single mode ultra-short pulsed laser source are presented as well as the currently on-going and promising laboratory research and micro machining results. Finally, an outlook of scaling the processing head to several tens of beams is given.

  4. Infrared Lasers in Chemistry.

    ERIC Educational Resources Information Center

    John, Phillip

    1982-01-01

    Selected infrared laser chemistry topics are discussed including carbon dioxide lasers, infrared quanta and molecules, laser-induced chemistry, structural isomerization (laser purification, sensitized reactions, and dielectric breakdown), and fundamental principles of laser isotope separation, focusing on uranium isotope separation. (JN)

  5. High-energy ultra-short pulse thin-disk lasers: new developments and applications

    NASA Astrophysics Data System (ADS)

    Michel, Knut; Klingebiel, Sandro; Schultze, Marcel; Tesseit, Catherine Y.; Bessing, Robert; Häfner, Matthias; Prinz, Stefan; Sutter, Dirk; Metzger, Thomas

    2016-03-01

    We report on the latest developments at TRUMPF Scientific Lasers in the field of ultra-short pulse lasers with highest output energies and powers. All systems are based on the mature and industrialized thin-disk technology of TRUMPF. Thin Yb:YAG disks provide a reliable and efficient solution for power and energy scaling to Joule- and kW-class picosecond laser systems. Due to its efficient one dimensional heat removal, the thin-disk exhibits low distortions and thermal lensing even when pumped under extremely high pump power densities of 10kW/cm². Currently TRUMPF Scientific Lasers develops regenerative amplifiers with highest average powers, optical parametric amplifiers and synchronization schemes. The first few-ps kHz multi-mJ thin-disk regenerative amplifier based on the TRUMPF thindisk technology was developed at the LMU Munich in 20081. Since the average power and energy have continuously been increased, reaching more than 300W (10kHz repetition rate) and 200mJ (1kHz repetition rate) at pulse durations below 2ps. First experiments have shown that the current thin-disk technology supports ultra-short pulse laser solutions >1kW of average power. Based on few-picosecond thin-disk regenerative amplifiers few-cycle optical parametric chirped pulse amplifiers (OPCPA) can be realized. These systems have proven to be the only method for scaling few-cycle pulses to the multi-mJ energy level. OPA based few-cycle systems will allow for many applications such as attosecond spectroscopy, THz spectroscopy and imaging, laser wake field acceleration, table-top few-fs accelerators and laser-driven coherent X-ray undulator sources. Furthermore, high-energy picosecond sources can directly be used for a variety of applications such as X-ray generation or in atmospheric research.

  6. Development of ultrashort x-ray/gamma-ray sources using ultrahigh power lasers (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Kim, Hyung Taek; Nakajima, Kazuhisa; Hojbota, Calin; Jeon, Jong Ho; Rhee, Yong-Joo; Lee, Kyung Hwan; Lee, Seong Ku; Sung, Jae Hee; Lee, Hwang Woon; Pathak, Vishwa B.; Pae, Ki Hong; Sebban, Stéphane; Tissandier, Fabien; Gautier, Julien; Ta Phuoc, Kim; Malka, Victor; Nam, Chang Hee

    2017-05-01

    Short-pulse x-ray/gamma-ray sources have become indispensable light sources for investigating material science, bio technology, and photo-nuclear physics. In past decades, rapid advancement of high intensity laser technology led extensive progresses in the field of radiation sources based on laser-plasma interactions - x-ray lasers, betatron radiation and Compton gamma-rays. Ever since the installation of a 100-TW laser in 2006, we have pursued the development of ultrashort x-ray/gamma-ray radiations, such as x-ray lasers, relativistic high-order harmonics, betatron radiation and all-optical Compton gamma-rays. With the construction of two PW Ti:Sapphire laser beamlines having peak powers of 1.0 PW and 1.5 PW in 2010 and 2012, respectively [1], we have investigated the generation of multi-GeV electron beams [2] and MeV betatron radiations. We plan to carry out the Compton backscattering to generate MeV gamma-rays from the interaction of a GeV electron beam and a PW laser beam. Here, we present the recent progress in the development of ultrashort x-ray/gamma-ray radiation sources based on laser plasma interactions and the plan for developing Compton gamma-ray sources driven by the PW lasers. In addition, we will present the applications of laser-plasma x-ray lasers to x-ray holography and coherent diffraction imaging. [references] 1. J. H. Sung, S. K. Lee, T. J. Yu, T. M. Jeong, and J. Lee, Opt. Lett. 35, 3021 (2010). 2. H. T. Kim, K. H. Pae, H. J. Cha, I J. Kim, T. J. Yu, J. H. Sung, S. K. Lee, T. M. Jeong, J. Lee, Phys. Rev. Lett. 111, 165002 (2013).

  7. Ultrashort high-brightness pulses from storage rings

    NASA Astrophysics Data System (ADS)

    Khan, Shaukat

    2017-09-01

    The brightness of short-wavelength radiation from accelerator-based sources can be increased by coherent emission in which the radiation intensity scales with the number of contributing electrons squared. This requires a microbunched longitudinal electron distribution, which is the case in free-electron lasers. The brightness of light sources based on electron storage rings was steadily improved, but could profit further from coherent emission. The modulation of the electron energy by a continuous-wave laser field may provide steady-state microbunching in the infrared regime. For shorter wavelengths, the energy modulation can be converted into a temporary density modulation by a dispersive chicane. One particular goal is coherent emission from a very short "slice" within an electron bunch in order to produce ultrashort radiation pulses with high brightness.

  8. Wear-reducing Surface Functionalization of Implant Materials Using Ultrashort Laser Pulses

    NASA Astrophysics Data System (ADS)

    Oldorf, P.; Peters, R.; Reichel, S.; Schulz, A.-P.; Wendlandt, R.

    The aim of the project called "EndoLas" is the development of a reproducible and reliable method for a functionalization of articulating surfaces on hip joint endoprostheses due to a reduction of abrasion and wear by the generation of micro structures using ultrashort laser pulses. On the one hand, the microstructures shall ensure the capture of abraded particles, which cause third-body wear and thereby increase aseptic loosening. On the other hand, the structures shall improve or maintain the tribologically important lubricating film. Thereby, the cavities serve as a reservoir for the body's own synovial fluid. The dry friction, which promotes abrasion and is a part of the mixed friction in the joint, shall therefore be reduced. In experimental setups it was shown, that the abrasive wear can be reduced significantly due to micro-structuring the articulating implant surfaces. To shape the fine and deterministic cavities on the surfaces, an ultra-short pulsed laser, which is integrated in a high-precision, 5-axes micro-machining system, was used. The laser system, based on an Yb:YAG thin-disk regenerative amplifier, has an average output power of 50 W at the fundamental wavelength of 1030 nm, a maximum repetition rate of 400 kHz and a pulse duration of 6 ps. Due to this, a maximum pulse energy of 125 μJ is achievable. Furthermore external second and third harmonic generation enables the usage of wavelengths in the green and violet spectral range.

  9. Generation and application of ultrashort coherent mid-infrared electromagnetic radiation

    NASA Astrophysics Data System (ADS)

    Wandel, Scott

    Particle accelerators are useful instruments that help address critical issues for the future development of nuclear energy. Current state-of-the-art accelerators based on conventional radio-frequency (rf) cavities are too large and expensive for widespread commercial use, and alternative designs must be considered for supplying relativistic beams to small-scale applications, including medical imaging, secu- rity screening, and scientific research in a university-scale laboratory. Laser-driven acceleration using micro-fabricated dielectric photonic structures is an attractive approach because such photonic microstructures can support accelerating fields that are 10 to 100 times higher than that of rf cavity-based accelerators. Dielectric laser accelerators (DLAs) use commercial lasers as a driving source, which are smaller and less expensive than the klystrons used to drive current rf-based accelerators. Despite the apparent need for compact and economical laser sources for laser-driven acceleration, the availability of suitable high-peak-power lasers that cover a broad spectral range is currently limited. To address the needs of several innovative acceleration mechanisms like DLA, it is proposed to develop a coherent source of mid-infrared (IR) electromagnetic radiation that can be implemented as a driving source of laser accelerators. The use of ultrashort mid-IR high peak power laser systems in various laser-driven acceleration schemes has shown the potential to greatly reduce the optical pump intensities needed to realize high acceleration gradients. The optical intensity needed to achieve a given ponderomotive potential is 25 times less when using a 5-mum mid-IR laser as compared to using a 1-mum near-IR solid-state laser. In addition, dielectric structure breakdown caused by multiphoton ionization can be avoided by using longer-wavelength driving lasers. Current mid-IR laser sources do not produce sufficiently short pulse durations, broad spectral bandwidths

  10. Coulomb explosion of hydrogen clusters irradiated by an ultrashort intense laser pulse

    NASA Astrophysics Data System (ADS)

    Li, Hongyu; Liu, Jiansheng; Wang, Cheng; Ni, Guoquan; Li, Ruxin; Xu, Zhizhan

    2006-08-01

    The explosion dynamics of hydrogen clusters driven by an ultrashort intense laser pulse has been analyzed analytically and numerically by employing a simplified Coulomb explosion model. The dependence of average and maximum proton kinetic energy on cluster size, pulse duration, and laser intensity has been investigated respectively. The existence of an optimum cluster size allows the proton energy to reach the maximum when the cluster size matches with the intensity and the duration of the laser pulse. In order to explain our experimental results such as the measured proton energy spectrum and the saturation effect of proton energy, the effects of cluster size distribution as well as the laser intensity distribution on the focus spot should be considered. A good agreement between them is obtained.

  11. The diagnostics of ultra-short pulse laser-produced plasma

    NASA Astrophysics Data System (ADS)

    Roth, Markus

    2011-09-01

    Since the invention of the laser, coherent light has been used to break down solid or gaseous material and transform it into a plasma. Over the last three decades two things have changed. Due to multiple advancements and design of high power lasers it is now possible to increase the electric and magnetic field strength that pushed the electron motion towards the regime of relativistic plasma physics. Moreover, due to the short pulse duration of the driving laser the underlying physics has become so transient that concepts like thermal equilibrium (even a local one) or spatial isotropy start to fail. Consequently short pulse laser-driven plasmas have become a rich source of new phenomena that we are just about beginning to explore. Such phenomena, like particle acceleration, nuclear laser-induced reactions, the generation of coherent secondary radiation ranging from THz to high harmonics and the production of attosecond pulses have excited an enormous interest in the study of short pulse laser plasmas. The diagnostics of such ultra-short pulse laser plasmas is a challenging task that involves many and different techniques compared to conventional laser-produced plasmas. While this review cannot cover the entire field of diagnostics that has been developed over the last years, we will try to give a summarizing description of the most important techniques that are currently being used.

  12. Characteristics of Ions Emission from Ultrashort Laser Produced Plasma

    PubMed Central

    Elsied, Ahmed M.; Termini, Nicholas C.; Diwakar, Prasoon K.; Hassanein, Ahmed

    2016-01-01

    The dynamic characteristics of the ions emitted from ultrashort laser interaction with materials were studied. A series of successive experiments were conducted for six different elements (C, Al, Cu, Mo, Gd, and W) using 40 fs, 800 nm Ti: Sapphire laser. Time-of-flight (TOF) ion profile was analyzed and charge emission dependencies were investigated. The effects of incident laser interaction with each element were studied over a wide range of laser fluences (0.8 J/cm2 to 24 J/cm2) corresponding to laser intensities (2.0 × 1013 W/cm2 to 6.0 × 1014 W/cm2). The dependencies of the angular resolved ion flux and energy were also investigated. The TOF ion profile exhibits two peaks corresponding to a fast and a slow ion regime. The slow ions emission was the result of thermal vaporization while fast ions emission was due to time dependent ambipolar electric field. A theoretical model is proposed to predict the total ion flux emitted during femtosecond laser interaction that depends on laser parameters, material properties, and plume hydrodynamics. Incident laser fluence directly impacts average charge state and in turn affects the ion flux. Slow ions velocity exhibited different behavior from fast ions velocity. The fast ions energy and flux were found to be more collimated. PMID:27905553

  13. Time-resolved microscopy reveals the driving mechanism of particle formation during ultrashort pulse laser ablation of dentin-like ivory

    NASA Astrophysics Data System (ADS)

    Domke, Matthias; Gavrilova, Anna; Rapp, Stephan; Frentzen, Matthias; Meister, Joerg; Huber, Heinz P.

    2015-07-01

    In dental health care, the application of ultrashort laser pulses enables dental tissue ablation free from thermal side effects, such as melting and cracking. However, these laser types create undesired micro- and nanoparticles, which might cause a health risk for the patient or surgeon. The aim of this study was to investigate the driving mechanisms of micro- and nanoparticle formation during ultrashort pulse laser ablation of dental tissue. Time-resolved microscopy was chosen to observe the ablation dynamics of mammoth ivory after irradiation with 660 fs laser pulses. The results suggest that nanoparticles might arise in the excited region. The thermal expansion of the excited material induces high pressure in the surrounding bulk tissue, generating a pressure wave. The rarefaction wave behind this pressure wave causes spallation, leading to ejection of microparticles.

  14. The time resolved measurement of ultrashort terahertz-band electric fields without an ultrashort probe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walsh, D. A., E-mail: david.walsh@stfc.ac.uk; Snedden, E. W.; Jamison, S. P.

    The time-resolved detection of ultrashort pulsed THz-band electric field temporal profiles without an ultrashort laser probe is demonstrated. A non-linear interaction between a narrow-bandwidth optical probe and the THz pulse transposes the THz spectral intensity and phase information to the optical region, thereby generating an optical pulse whose temporal electric field envelope replicates the temporal profile of the real THz electric field. This optical envelope is characterised via an autocorrelation based FROG (frequency resolved optical gating) measurement, hence revealing the THz temporal profile. The combination of a narrow-bandwidth, long duration, optical probe, and self-referenced FROG makes the technique inherently immunemore » to timing jitter between the optical probe and THz pulse and may find particular application where the THz field is not initially generated via ultrashort laser methods, such as the measurement of longitudinal electron bunch profiles in particle accelerators.« less

  15. Underwater acoustic wave generation by filamentation of terawatt ultrashort laser pulses.

    PubMed

    Jukna, Vytautas; Jarnac, Amélie; Milián, Carles; Brelet, Yohann; Carbonnel, Jérôme; André, Yves-Bernard; Guillermin, Régine; Sessarego, Jean-Pierre; Fattaccioli, Dominique; Mysyrowicz, André; Couairon, Arnaud; Houard, Aurélien

    2016-06-01

    Acoustic signals generated by filamentation of ultrashort terawatt laser pulses in water are characterized experimentally. Measurements reveal a strong influence of input pulse duration on the shape and intensity of the acoustic wave. Numerical simulations of the laser pulse nonlinear propagation and the subsequent water hydrodynamics and acoustic wave generation show that the strong acoustic emission is related to the mechanism of superfilamention in water. The elongated shape of the plasma volume where energy is deposited drives the far-field profile of the acoustic signal, which takes the form of a radially directed pressure wave with a single oscillation and a very broad spectrum.

  16. Photo-ionization and modification of nanoparticles on transparent substrates by ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Gruzdev, Vitaly; Komolov, Vladimir; Li, Hao; Yu, Qingsong; Przhibel'skii, Sergey; Smirnov, Dmitry

    2011-02-01

    The objective of this combined experimental and theoretical research is to study the dynamics and mechanisms of nanoparticle interaction with ultrashort laser pulses and related modifications of substrate surface. For the experimental effort, metal (gold), dielectric (SiO2) and dielectric with metal coating (about 30 nm thick) spherical nanoparticles deposited on glass substrate are utilized. Size of the particles varies from 20 to 200 nm. Density of the particles varies from low (mean inter-particle distance 100 nm) to high (mean inter-particle distance less than 1 nm). The nanoparticle assemblies and the corresponding empty substrate surfaces are irradiated with single 130-fs laser pulses at wavelength 775 nm and different levels of laser fluence. Large diameter of laser spot (0.5-2 mm) provides gradient variations of laser intensity over the spot and allows observing different laser-nanoparticle interactions. The interactions vary from total removal of the nanoparticles in the center of laser spot to gentle modification of their size and shape and totally non-destructive interaction. The removed particles frequently form specific sub-micrometer-size pits on the substrate surface at their locations. The experimental effort is supported by simulations of the nanoparticle interactions with high-intensity ultrashort laser pulse. The simulation employs specific modification of the molecular dynamics approach applied to model the processes of non-thermal particle ablation following laser-induced electron emission. This technique delivers various characteristics of the ablation plume from a single nanoparticle including energy and speed distribution of emitted ions, variations of particle size and overall dynamics of its ablation. The considered geometry includes single isolated particle as well a single particle on a flat substrate that corresponds to the experimental conditions. The simulations confirm existence of the different regimes of laser

  17. Coulomb explosion of hydrogen clusters irradiated by an ultrashort intense laser pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li Hongyu; Liu Jiansheng; Wang Cheng

    The explosion dynamics of hydrogen clusters driven by an ultrashort intense laser pulse has been analyzed analytically and numerically by employing a simplified Coulomb explosion model. The dependence of average and maximum proton kinetic energy on cluster size, pulse duration, and laser intensity has been investigated respectively. The existence of an optimum cluster size allows the proton energy to reach the maximum when the cluster size matches with the intensity and the duration of the laser pulse. In order to explain our experimental results such as the measured proton energy spectrum and the saturation effect of proton energy, the effectsmore » of cluster size distribution as well as the laser intensity distribution on the focus spot should be considered. A good agreement between them is obtained.« less

  18. Fabrication of Nb/Pb structures through ultrashort pulsed laser deposition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gontad, Francisco; Lorusso, Antonella, E-mail: antonella.lorusso@le.infn.it; Perrone, Alessio

    This work reports the fabrication of Nb/Pb structures with an application as photocathode devices. The use of relatively low energy densities for the ablation of Nb with ultrashort pulses favors the reduction of droplets during the growth of the film. However, the use of laser fluences in this ablation regime results in a consequent reduction in the average deposition rate. On the other hand, despite the low deposition rate, the films present a superior adherence to the substrate and an excellent coverage of the irregular substrate surface, avoiding the appearance of voids or discontinuities on the film surface. Moreover, themore » low energy densities used for the ablation favor the growth of nanocrystalline films with a similar crystalline structure to the bulk material. Therefore, the use of low ablation energy densities with ultrashort pulses for the deposition of the Nb thin films allows the growth of very adherent and nanocrystalline films with adequate properties for the fabrication of Nb/Pb structures to be included in superconducting radiofrequency cavities.« less

  19. Generation of Ultrashort Pulses from Chromium - Forsterite Laser

    NASA Astrophysics Data System (ADS)

    Seas, Antonios

    This thesis discusses the generation of ultrashort pulses from the chromium-doped forsterite laser, the various designs, construction and operation of forsterite laser systems capable of generating picosecond and femtosecond pulses in the near infrared. Various mode-locking techniques including synchronous optical pumping, active mode-locking, and self-mode-locking were successfully engineered and implemented. Active and synchronously pumped mode-locking using a three mirror, astigmatically compensated cavity design and a forsterite crystal with a figure of merit of 26 (FOM = alpha_{rm 1064nm} /alpha_{rm 1250nm }) generated pulses with FWHM of 49 and 260 ps, respectively. The tuning range of the mode-locked forsterite laser in both cases was determined to be in the order of 100 nm limited only by the dielectric coatings of the mirrors used in the cavity. The slope efficiency was measured to be 12.5% for synchronous pumping and 9.1% for active mode-locking. A four mirror astigmatically compensated cavity was found to be more appropriate for mode-locking. Active mode-locking using the four-mirror cavity generated pulses with FWHM of 31 ps. The pulsewidth was further reduced to 6 ps by using a forsterite crystal with a higher figure of merit (FOM = 39). Pulsewidth-bandwidth measurements indicated the presence of chirp in the output pulses. Numerical calculation of the phase characteristics of various optical materials indicated that a pair of prisms made of SF 14 optical glass can be used in the cavity in order to compensate for the chirp. The insertion of the prisms in the cavity resulted in a reduction of the pulsewidth from 6 ps down to 900 fs. Careful optimization of the laser cavity resulted in the generation of stable 90-fs pulses. Pulses as short as 60 fs were generated and self-mode-locked mode of operation using the Cr:forsterite laser was demonstrated for the first time. Pure self-mode-locking was next achieved generating 105-fs pulses tunable between 1230

  20. Two-dimensional angular energy spectrum of electrons accelerated by the ultra-short relativistic laser pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Borovskiy, A. V.; Galkin, A. L.; Department of Physics of MBF, Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, Moscow 117997

    The new method of calculating energy spectra of accelerated electrons, based on the parameterization by their initial coordinates, is proposed. The energy spectra of electrons accelerated by Gaussian ultra-short relativistic laser pulse at a selected angle to the axis of the optical system focusing the laser pulse in a low density gas are theoretically calculated. The two-peak structure of the electron energy spectrum is obtained. Discussed are the reasons for its appearance as well as an applicability of other models of the laser field.

  1. Prompt increase of ultrashort laser pulse transmission through thin silver films

    NASA Astrophysics Data System (ADS)

    Bezhanov, S. G.; Danilov, P. A.; Klekovkin, A. V.; Kudryashov, S. I.; Rudenko, A. A.; Uryupin, S. A.

    2018-03-01

    We study experimentally and numerically the increase in ultrashort laser pulse transmissivity through thin silver films caused by the heating of electrons. Low to moderate energy femtosecond laser pulse transmission measurements through 40-125 nm thickness silver films were carried out. We compare the experimental data with the values of transmitted fraction of energy obtained by solving the equations for the field together with the two-temperature model. The measured values were fitted with sufficient accuracy by varying the electron-electron collision frequency whose exact values are usually poorly known. Since transmissivity experiences more pronounced changes with the increase in temperature compared to reflectivity, we suggest this technique for studying the properties of nonequilibrium metals.

  2. Studies of Inactivation Mechanism of non-enveloped icosahedral viruses by a visible ultrashort pulsed laser

    USDA-ARS?s Scientific Manuscript database

    The inactivation mechanism of ultrashort pulsed laser irradiation at a wavelength of 425 nm has been studied using two different-sized, non-enveloped icosahedral viruses, murine norovirus-1 (MNV-1) and human papillomavirus-16 (HPV-16) pseudovirions. Our experimental results are consistent with a mo...

  3. Anomalous transmission of an ultrashort ionizing laser pulse through a thin foil.

    PubMed

    Ferrante, G; Zarcone, M; Uryupin, S A

    2003-08-22

    The formation of a highly anisotropic photoelectron velocity distribution as a result of the interaction of a powerful ultrashort laser pulse with a thin foil is found to yield a large skin-layer depth and an anomalous increase of the transmission coefficient. The physical reason for the effect is the influence of the incident wave magnetic field, through the Lorenz force, on the electron kinetics in the skin layer.

  4. Crack-free conditions in welding of glass by ultrashort laser pulse.

    PubMed

    Miyamoto, Isamu; Cvecek, Kristian; Schmidt, Michael

    2013-06-17

    The spatial distribution of the laser energy absorbed by nonlinear absorption process in bulk glass w(z) is determined and thermal cycles due to the successive ultrashort laser pulse (USLP) is simulated using w(z) based on the transient thermal conduction model. The thermal stress produced in internal melting of bulk glass by USLP is qualitatively analyzed based on a simple thermal stress model, and crack-free conditions are studied in glass having large coefficient of thermal expansion. In heating process, cracks are prevented when the laser pulse impinges into glass with temperatures higher than the softening temperature of glass. In cooling process, shrinkage stress is suppressed to prevent cracks, because the embedded molten pool produced by nonlinear absorption process behaves like an elastic body under the compressive stress field unlike the case of CW-laser welding where the molten pool having a free surface produced by linear absorption process is plastically deformed under the compressive stress field.

  5. Nonlinear Thomson scattering of a relativistically strong tightly focused ultrashort laser pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vais, O. E.; Bochkarev, S. G., E-mail: bochkar@sci.lebedev.ru; Bychenkov, V. Yu.

    The problem of nonlinear Thomson scattering of a relativistically strong linearly polarized ultrashort laser pulse tightly focused into a spot with a diameter of D{sub F} ≳ λ (where λ is the laser wavelength) is solved. The energy, spectral, and angular distributions of radiation generated due to Thomson scattering from test electrons located in the focal region are found. The characteristics of scattered radiation are studied as functions of the tightness of laser focusing and the initial position of test particles relative to the center of the focal region for a given laser pulse energy. It is demonstrated that themore » ultratight focusing is not optimal for obtaining the brightest and hardest source of secondary electromagnetic radiation. The hardest and shortest radiation pulse is generated when the beam waist diameter is ≃10λ.« less

  6. Numerical calculation of nonlinear ultrashort laser pulse propagation in transparent Kerr media

    NASA Astrophysics Data System (ADS)

    Arnold, Cord L.; Heisterkamp, Alexander; Ertmer, Wolfgang; Lubatschowski, Holger

    2005-03-01

    In the focal region of tightly focused ultrashort laser pulses, sufficient high intensities to initialize nonlinear ionization processes are easily achieved. Due to these nonlinear ionization processes, mainly multiphoton ionization and cascade ionization, free electrons are generated in the focus resulting in optical breakdown. A model including both nonlinear pulse propagation and plasma generation is used to calculate numerically the interaction of ultrashort pulses with their self-induced plasma in the vicinity of the focus. The model is based on a (3+1)-dimensional nonlinear Schroedinger equation describing the pulse propagation coupled to a system of rate equations covering the generation of free electrons. It is applicable to any transparent Kerr medium, whose linear and nonlinear optical parameters are known. Numerical calculations based on this model are used to understand nonlinear side effects, such as streak formation, occurring in addition to optical breakdown during short pulse refractive eye surgeries like fs-LASIK. Since the optical parameters of water are a good first-order approximation to those of corneal tissue, water is used as model substance. The free electron density distribution induced by focused ultrashort pulses as well as the pulses spatio-temporal behavior are studied in the low-power regime around the critical power for self-focusing.

  7. Dynamics of laser-induced damage of spherical nanoparticles by high-intensity ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Komolov, Vladimir L.; Gruzdev, Vitaly E.; Przhibelskii, Sergey G.; Smirnov, Dmitry S.

    2012-12-01

    Damage of a metal spherical nanoparticle by femtosecond laser pulses is analyzed by splitting the overall process into two steps. The fast step includes electron photoemission from a nanoparticle. It takes place during direct action of a laser pulse and its rate is evaluated as a function of laser and particle parameters by two approaches. Obtained results suggest the formation of significant positive charge of the nanoparticles due to the photoemission. The next step includes ion emission that removes the excessive positive charge and modifies particle structure. It is delayed with respect to the photo-emission and is analyzed by a simple analytical model and modified molecular dynamics. Obtained energy distribution suggests generation of fast ions capable of penetrating into surrounding material and generating defects next to the nanoparticle. The modeling is extended to the case of a nanoparticle on a solid surface to understand the basic mechanism of surface laser damage initiated by nano-contamination. Simulations predict embedding the emitted ions into substrate within a spot with size significantly exceeding the original particle size. We discuss the relation of those effects to the problem of bulk and surface laser-induced damage of optical materials by single and multiple ultrashort laser pulses.

  8. Growth and Spectral Assessment of Yb3+-Doped KBaGd(MoO4)3 Crystal: A Candidate for Ultrashort Pulse and Tunable Lasers

    PubMed Central

    Yu, Yi; Huang, Yisheng; Zhang, Lizhen; Lin, Zhoubin; Wang, Guofu

    2013-01-01

    In order to explore new more powerful ultrashort pulse laser and tunable laser for diode-pumping, this paper reports the growth and spectral assessment of Yb3+-doped KBaGd(MoO4)3 crystal. An Yb3+:KBaGd(MoO4)3 crystal with dimensions of 50×40×9 mm3 was grown by the TSSG method from the K2Mo2O7 flux. The investigated spectral properties indicated that Yb3+:KBaGd(MoO4)3 crystal exhibits broad absorption and emission bands, except the large emission and gain cross-sections. This feature of the broad absorption and emission bands is not only suitable for the diode pumping, but also for the production of ultrashort pulses and tunability. Therefore, Yb3+:KBaGd(MoO4)3 crystal can be regarded as a candidate for the ultrashort pulse and tunable lasers. PMID:23349892

  9. Growth and spectral assessment of Yb(3+)-doped KBaGd(MoO4)3 crystal: a candidate for ultrashort pulse and tunable lasers.

    PubMed

    Yu, Yi; Huang, Yisheng; Zhang, Lizhen; Lin, Zhoubin; Wang, Guofu

    2013-01-01

    In order to explore new more powerful ultrashort pulse laser and tunable laser for diode-pumping, this paper reports the growth and spectral assessment of Yb(3+)-doped KBaGd(MoO(4))(3) crystal. An Yb(3+):KBaGd(MoO(4))(3) crystal with dimensions of 50×40×9 mm(3) was grown by the TSSG method from the K(2)Mo(2)O(7) flux. The investigated spectral properties indicated that Yb(3+):KBaGd(MoO(4))(3) crystal exhibits broad absorption and emission bands, except the large emission and gain cross-sections. This feature of the broad absorption and emission bands is not only suitable for the diode pumping, but also for the production of ultrashort pulses and tunability. Therefore, Yb(3+):KBaGd(MoO(4))(3) crystal can be regarded as a candidate for the ultrashort pulse and tunable lasers.

  10. Electromagnetic fields of an ultra-short tightly-focused radially-polarized laser pulse

    NASA Astrophysics Data System (ADS)

    Salamin, Yousef I.; Li, Jian-Xing

    2017-12-01

    Fully analytic expressions, for the electric and magnetic fields of an ultrashort and tightly focused laser pulse of the radially polarized category, are presented to lowest order of approximation. The fields are derived from scalar and vector potentials, along the lines of our earlier work for a similar pulse of the linearly polarized variety. A systematic program is also described from which the fields may be obtained to any desired accuracy, analytically or numerically.

  11. Propagation of an ultrashort, intense laser pulse in a relativistic plasma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ritchie, B.; Decker, C.D.

    1997-12-31

    A Maxwell-relativistic fluid model is developed for the propagation of an ultrashort, intense laser pulse through an underdense plasma. The separability of plasma and optical frequencies ({omega}{sub p} and {omega} respectively) for small {omega}{sub p}/{omega} is not assumed; thus the validity of multiple-scales theory (MST) can be tested. The theory is valid when {omega}{sub p}/{omega} is of order unity or for cases in which {omega}{sub p}/{omega} {much_lt} 1 but strongly relativistic motion causes higher-order plasma harmonics to be generated which overlap the region of the first-order laser harmonic, such that MST would not expected to be valid although its principalmore » validity criterion {omega}{sub p}/{omega} {much_lt} 1 holds.« less

  12. Interaction of ultrashort laser pulses and silicon solar cells under short circuit conditions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mundus, M., E-mail: markus.mundus@ise.fraunhofer.de; Giesecke, J. A.; Fischer, P.

    Ultrashort pulse lasers are promising tools for numerous measurement purposes. Among other benefits their high peak powers allow for efficient generation of wavelengths in broad spectral ranges and at spectral powers that are orders of magnitude higher than in conventional light sources. Very recently this has been exploited for the establishment of sophisticated measurement facilities for electrical characterization of photovoltaic (PV) devices. As the high peak powers of ultrashort pulses promote nonlinear optical effects they might also give rise to nonlinear interactions with the devices under test that possibly manipulate the measurement outcome. In this paper, we present a comprehensivemore » theoretical and experimental study of the nonlinearities affecting short circuit current (I{sub SC}) measurements of silicon (Si) solar cells. We derive a set of coupled differential equations describing the radiation-device interaction and discuss the nonlinearities incorporated in those. By a semi-analytical approach introducing a quasi-steady-state approximation and integrating a Green's function we solve the system of equations and obtain simulated I{sub SC} values. We validate the theoretical model by I{sub SC} ratios obtained from a double ring resonator setup capable for reproducible generation of various ultrashort pulse trains. Finally, we apply the model to conduct the most prominent comparison of I{sub SC} generated by ultrashort pulses versus continuous illumination. We conclude by the important finding that the nonlinearities induced by ultrashort pulses are negligible for the most common I{sub SC} measurements. However, we also find that more specialized measurements (e.g., of concentrating PV or Si-multijunction devices as well as highly localized electrical characterizations) will be biased by two-photon-absorption distorting the I{sub SC} measurement.« less

  13. Highlighting the DNA damage response with ultrashort laser pulses in the near infrared and kinetic modeling

    PubMed Central

    Ferrando-May, Elisa; Tomas, Martin; Blumhardt, Philipp; Stöckl, Martin; Fuchs, Matthias; Leitenstorfer, Alfred

    2013-01-01

    Our understanding of the mechanisms governing the response to DNA damage in higher eucaryotes crucially depends on our ability to dissect the temporal and spatial organization of the cellular machinery responsible for maintaining genomic integrity. To achieve this goal, we need experimental tools to inflict DNA lesions with high spatial precision at pre-defined locations, and to visualize the ensuing reactions with adequate temporal resolution. Near-infrared femtosecond laser pulses focused through high-aperture objective lenses of advanced scanning microscopes offer the advantage of inducing DNA damage in a 3D-confined volume of subnuclear dimensions. This high spatial resolution results from the highly non-linear nature of the excitation process. Here we review recent progress based on the increasing availability of widely tunable and user-friendly technology of ultrafast lasers in the near infrared. We present a critical evaluation of this approach for DNA microdamage as compared to the currently prevalent use of UV or VIS laser irradiation, the latter in combination with photosensitizers. Current and future applications in the field of DNA repair and DNA-damage dependent chromatin dynamics are outlined. Finally, we discuss the requirement for proper simulation and quantitative modeling. We focus in particular on approaches to measure the effect of DNA damage on the mobility of nuclear proteins and consider the pros and cons of frequently used analysis models for FRAP and photoactivation and their applicability to non-linear photoperturbation experiments. PMID:23882280

  14. Generation of ultrashort pulses with minimum duration of 90\\ {\\text{fs}} in a hybrid mode-locked erbium-doped all-fibre ring laser

    NASA Astrophysics Data System (ADS)

    Dvoretskiy, D. A.; Sazonkin, S. G.; Voropaev, V. S.; Negin, M. A.; Leonov, S. O.; Pnev, A. B.; Karasik, V. E.; Denisov, L. K.; Krylov, A. A.; Davydov, V. A.; Obraztsova, E. D.

    2016-11-01

    Regimes of ultrashort pulse generation in an erbium-doped all-fibre ring laser with hybrid mode locking based on single-wall carbon - boron nitride nanotubes and the nonlinear Kerr effect in fibre waveguides are studied. Stable dechirped ultrashort pulses are obtained with a duration of ˜ 90 {\\text{fs}}, a repetition rate of ˜ 42.2 {\\text{MHz}}, and an average output power of ˜ 16.7 {\\text{mW}}, which corresponds to a pulse energy of ˜ 0.4 {\\text{nJ}} and a peak laser power of ˜ 4.4 {\\text{kW}}.

  15. Ultra-short laser interactions with nanoparticles in different media: from electromagnetic to thermal and electrostatic effects

    NASA Astrophysics Data System (ADS)

    Itina, Tatiana E.

    2017-02-01

    Key issues of the controlled synthesis of nanoparticles and nanostructures, as well as laser-particle interactions are considered in the context of the latest applications appearing in many fields such as photonics, medicine, 3D printing, etc. The results of a multi-physics numerical study of laser interaction with nanoparticles will be presented in the presence of several environments. In particular, attention will be paid to the numerical study of laser interactions with heterogeneous materials (eg. colloidal liquids and/or nanoparticles in a dielectric medium) and the aggregation/sintering/fragmentation processes induced by ultra-short laser pulses.

  16. Limits of applicability of a two-temperature model under nonuniform heating of metal by an ultrashort laser pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Polyakov, D S; Yakovlev, E B

    The heating of metals (silver and aluminium) by ultrashort laser pulses is analysed proceeding from a spatially nonuniform kinetic equation for the electron distribution function. The electron subsystem thermalisation is estimated in a wide range of absorbed pulse energy density. The limits of applicability are determined for the two-temperature model. (interaction of laser radiation with matter)

  17. Towards a petawatt-class few-cycle infrared laser system via dual-chirped optical parametric amplification.

    PubMed

    Fu, Yuxi; Midorikawa, Katsumi; Takahashi, Eiji J

    2018-05-16

    Expansion of the wavelength range for an ultrafast laser is an important ingredient for extending its range of applications. Conventionally, optical parametric amplification (OPA) has been employed to expand the laser wavelength to the infrared (IR) region. However, the achievable pulse energy and peak power have been limited to the mJ and the GW level, respectively. A major difficulty in the further energy scaling of OPA results from a lack of suitable large nonlinear crystals. Here, we circumvent this difficulty by employing a dual-chirped optical parametric amplification (DC-OPA) scheme. We successfully generate a multi-TW IR femtosecond laser pulse with an energy of 100 mJ order, which is higher than that reported in previous works. We also obtain excellent energy scaling ability, ultrashort pulses, flexiable wavelength tunability, and high-energy stability, which prove that DC-OPA is a superior method for the energy scaling of IR pulses to the 10 J/PW level.

  18. Mimicking lizard-like surface structures upon ultrashort laser pulse irradiation of inorganic materials

    NASA Astrophysics Data System (ADS)

    Hermens, U.; Kirner, S. V.; Emonts, C.; Comanns, P.; Skoulas, E.; Mimidis, A.; Mescheder, H.; Winands, K.; Krüger, J.; Stratakis, E.; Bonse, J.

    2017-10-01

    Inorganic materials, such as steel, were functionalized by ultrashort laser pulse irradiation (fs- to ps-range) to modify the surface's wetting behavior. The laser processing was performed by scanning the laser beam across the surface of initially polished flat sample material. A systematic experimental study of the laser processing parameters (peak fluence, scan velocity, line overlap) allowed the identification of different regimes associated with characteristic surface morphologies (laser-induced periodic surface structures, grooves, spikes, etc.). Analyses of the surface using optical as well as scanning electron microscopy revealed morphologies providing the optimum similarity to the natural skin of lizards. For mimicking skin structures of moisture-harvesting lizards towards an optimization of the surface wetting behavior, additionally a two-step laser processing strategy was established for realizing hierarchical microstructures. In this approach, micrometer-scaled capillaries (step 1) were superimposed by a laser-generated regular array of small dimples (step 2). Optical focus variation imaging measurements finally disclosed the three dimensional topography of the laser processed surfaces derived from lizard skin structures. The functionality of these surfaces was analyzed in view of wetting properties.

  19. Heat input and accumulation for ultrashort pulse processing with high average power

    NASA Astrophysics Data System (ADS)

    Finger, Johannes; Bornschlegel, Benedikt; Reininghaus, Martin; Dohrn, Andreas; Nießen, Markus; Gillner, Arnold; Poprawe, Reinhart

    2018-05-01

    Materials processing using ultrashort pulsed laser radiation with pulse durations <10 ps is known to enable very precise processing with negligible thermal load. However, even for the application of picosecond and femtosecond laser radiation, not the full amount of the absorbed energy is converted into ablation products and a distinct fraction of the absorbed energy remains as residual heat in the processed workpiece. For low average power and power densities, this heat is usually not relevant for the processing results and dissipates into the workpiece. In contrast, when higher average powers and repetition rates are applied to increase the throughput and upscale ultrashort pulse processing, this heat input becomes relevant and significantly affects the achieved processing results. In this paper, we outline the relevance of heat input for ultrashort pulse processing, starting with the heat input of a single ultrashort laser pulse. Heat accumulation during ultrashort pulse processing with high repetition rate is discussed as well as heat accumulation for materials processing using pulse bursts. In addition, the relevance of heat accumulation with multiple scanning passes and processing with multiple laser spots is shown.

  20. Femtosecond synchronism of x-rays and visible/infrared light in an x-ray free-electron laser

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, B. W.

    2007-12-15

    A way is proposed to obtain ultrashort pulses of intense infrared/visible light in few-femtosecond synchronism with x-rays from an x-ray free-electron laser (XFEL). It makes use of the recently proposed emittance-slicing technique [Emma et al., Phys. Rev. Lett. 92, 074801 (2004)] to both restrict the duration of self-amplified spontaneous emission (SASE) to a few femtoseconds and to lead to a coherence enhancement of near-infrared transition undulator radiation (CTUR). The x-rays and the near-infrared light originate within the XFEL undulator from the same slice of electrons within a bunch and are therefore perfectly synchronized with each other. An example of realizingmore » the scheme at the Linac Coherent Light Source is presented. A few side issues are explored briefly, such as the magnitude of the velocity term versus the acceleration term in the Lienard-Wiechert fields and the possible use of the CTUR as a diagnostic tool for the SASE process itself.« less

  1. Optimization of the parameters for intrastromal refractive surgery with ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Heisterkamp, Alexander; Ripken, Tammo; Lubatschowski, Holger; Welling, Herbert; Dommer, Wolfgang; Luetkefels, Elke; Mamom, Thanongsak; Ertmer, Wolfgang

    2001-06-01

    Focussing femtosecond laser pulses into a transparent media, such as corneal tissue, leads to optical breakdown, generation of a micro-plasma and, thus, a cutting effect inside the tissue. To proof the potential of fs-lasers in refractive surgery, three-dimensional cutting within the corneal stroma was evaluated. With the use of ultrashort laser pulses within the LASIK procedure (laser in situ keratomileusis) possible complications in handling of a mechanical knife, the microkeratome, can be reduced by using the treatment laser as the keratome itself. To study woundhealing effects, animal studies were carried out in rabbit specimen. The surgical outcome was analyzed by means of histological sections, as well as light and scanning electron microscopy. Dependencies on the dispersion caused by focussing optics were evaluated and optimized. Thus, pulse energies well below 1 (mu) J were sufficient to perform the intrastromal cuts. The laser pulses with a duration of 180 fs and energies of 0.5-100 (mu) J were provided by a modelocked frequency doubled erbium fiber-laser with subsequent chirped pulse amplification in a titanium sapphire amplifier at up to 3 kHz.

  2. co2amp: A software program for modeling the dynamics of ultrashort pulses in optical systems with CO 2 amplifiers

    DOE PAGES

    Polyanskiy, Mikhail N.

    2015-01-01

    We describe a computer code for simulating the amplification of ultrashort mid-infrared laser pulses in CO 2 amplifiers and their propagation through arbitrary optical systems. This code is based on a comprehensive model that includes an accurate consideration of the CO 2 active medium and a physical optics propagation algorithm, and takes into account the interaction of the laser pulse with the material of the optical elements. Finally, the application of the code for optimizing an isotopic regenerative amplifier is described.

  3. X-ray emission as a potential hazard during ultrashort pulse laser material processing

    NASA Astrophysics Data System (ADS)

    Legall, Herbert; Schwanke, Christoph; Pentzien, Simone; Dittmar, Günter; Bonse, Jörn; Krüger, Jörg

    2018-06-01

    In laser machining with ultrashort laser pulses unwanted X-ray radiation in the keV range can be generated when a critical laser intensity is exceeded. Even if the emitted X-ray dose per pulse is low, high laser repetition rates can lead to an accumulation of X-ray doses beyond exposure safety limits. For 925 fs pulse duration at a center wavelength of 1030 nm, the X-ray emission was investigated up to an intensity of 2.6 × 1014 W/cm2. The experiments were performed in air with a thin disk laser at a repetition rate of 400 kHz. X-ray spectra and doses were measured for various planar target materials covering a wide range of the periodic table from aluminum to tungsten. Without radiation shielding, the measured radiation doses at this high repetition rate clearly exceed the regulatory limits. Estimations for an adequate radiation shielding are provided.

  4. Fracture toughness of ultrashort pulse-bonded fused silica

    NASA Astrophysics Data System (ADS)

    Richter, S.; Naumann, F.; Zimmermann, F.; Tünnermann, A.; Nolte, S.

    2016-02-01

    We determined the bond interface strength of ultrashort pulse laser-welded fused silica for different processing parameters. To this end, we used a high repetition rate ultrashort pulse laser system to inscribe parallel welding lines with a specific V-shaped design into optically contacted fused silica samples. Afterward, we applied a micro-chevron test to measure the fracture toughness and surface energy of the laser-inscribed welding seams. We analyzed the influence of different processing parameters such as laser repetition rate and line separation on the fracture toughness and fracture surface energy. Welding the entire surface a fracture toughness of 0.71 {MPa} {m}^{1/2}, about 90 % of the pristine bulk material ({≈ } 0.8 {MPa} {m}^{1/2}), is obtained.

  5. Multi-dimensional simulation package for ultrashort pulse laser-matter interactions

    NASA Astrophysics Data System (ADS)

    Suslova, Anastassiya; Hassanein, Ahmed

    2017-10-01

    Advanced simulation models recently became a popular tool of investigation of ultrashort pulse lasers (USPLs) to enhance understanding of the physics and allow minimizing the experimental costs for optimization of laser and target parameters for various applications. Our research interest is focused on developing multi-dimensional simulation package FEMTO-2D to investigate the USPL-matter interactions and laser induced effects. The package is based on solution of two heat conduction equations for electron and lattice sub-systems - enhanced two temperature model (TTM). We have implemented theoretical approach based on the collision theory to define the thermal dependence of target material optical properties and thermodynamic parameters. Our approach allowed elimination of fitted parameters commonly used in TTM based simulations. FEMTO-2D is used to simulated the light absorption and interactions for several metallic targets as a function of wavelength and pulse duration for wide range of laser intensity. The package has capability to consider different angles of incidence and polarization. It has also been used to investigate the damage threshold of the gold coated optical components with the focus on the role of the film thickness and substrate heat sink effect. This work was supported by the NSF, PIRE project.

  6. Estimation of ultrashort laser irradiation effect over thin transparent biopolymer films morphology

    NASA Astrophysics Data System (ADS)

    Daskalova, A.; Nathala, C.; Bliznakova, I.; Slavov, D.; Husinsky, W.

    2015-01-01

    The collagen - elastin biopolymer thin films treated by CPA Ti:Sapphire laser (Femtopower - Compact Pro) at 800nm central wavelength with 30fs and 1kHz repetition rate are investigated. A process of surface modifications and microporous scaffold creation after ultrashort laser irradiation has been observed. The single-shot (N=1) and multi-shot (N<1) ablation threshold values were estimated by studying the linear relationship between the square of the crater diameter D2 and the logarithm of the laser fluence F for determination of the threshold fluences for N=1, 2, 5, 10, 15 and 30 number of laser pulses. The incubation analysis by calculation of the incubation coefficient ξ for multi - shot fluence threshold for selected materials by power - law relationship form Fth(N)=Fth(1)Nξ-1 was also obtained. In this paper, we have also shown another consideration of the multi - shot ablation threshold calculation by logarithmic dependence of the ablation rate d on the laser fluence. The morphological surface changes of the modified regions were characterized by scanning electron microscopy to estimate the generated variations after the laser treatment.

  7. Near infrared lasers in flow cytometry.

    PubMed

    Telford, William G

    2015-07-01

    Technology development in flow cytometry has closely tracked laser technology, the light source that flow cytometers almost exclusively use to excite fluorescent probes. The original flow cytometers from the 1970s and 1980s used large water-cooled lasers to produce only one or two laser lines at a time. Modern cytometers can take advantage of the revolution in solid state laser technology to use almost any laser wavelength ranging from the ultraviolet to the near infrared. Commercial cytometers can now be equipped with many small solid state lasers, providing almost any wavelength needed for cellular analysis. Flow cytometers are now equipped to analyze 20 or more fluorescent probes simultaneously, requiring multiple laser wavelengths. Instrument developers are now trying to increase this number by designing fluorescent probes that can be excited by laser wavelength at the "edges" of the visible light range, in the near ultraviolet and near-infrared region. A variety of fluorescent probes have been developed that excite with violet and long wavelength ultraviolet light; however, the near-infrared range (660-800 nm) has yet seen only exploitation in flow cytometry. Fortunately, near-infrared laser diodes and other solid state laser technologies appropriate for flow cytometry have been in existence for some time, and can be readily incorporated into flow cytometers to accelerate fluorescent probe development. The near infrared region represents one of the last "frontiers" to maximize the number of fluorescent probes that can be analyzed by flow cytometry. In addition, near infrared fluorescent probes used in biomedical tracking and imaging could also be employed for flow cytometry with the correct laser wavelengths. This review describes the available technology, including lasers, fluorescent probes and detector technology optimal for near infrared signal detection. Published by Elsevier Inc.

  8. Investigation of ultrashort-pulsed laser on dental hard tissue

    NASA Astrophysics Data System (ADS)

    Uchizono, Takeyuki; Awazu, Kunio; Igarashi, Akihiro; Kato, Junji; Hirai, Yoshito

    2007-02-01

    Ultrashort-pulsed laser (USPL) can ablate various materials with precious less thermal effect. In laser dentistry, to solve the problem that were the generation of crack and carbonized layer by irradiating with conventional laser such as Er:YAG and CO II laser, USPL has been studied to ablate dental hard tissues by several researchers. We investigated the effectiveness of ablation on dental hard tissues by USPL. In this study, Ti:sapphire laser as USPL was used. The laser parameter had the pulse duration of 130 fsec, 800nm wavelength, 1KHz of repetition rate and the average power density of 90~360W/cm2. Bovine root dentin plates and crown enamel plates were irradiated with USPL at 1mm/sec using moving stage. The irradiated samples were analyzed by SEM, EDX, FTIR and roughness meter. In all irradiated samples, the cavity margin and wall were sharp and steep, extremely. In irradiated dentin samples, the surface showed the opened dentin tubules and no smear layer. The Ca/P ratio by EDX measurement and the optical spectrum by FTIR measurement had no change on comparison irradiated samples and non-irradiated samples. These results confirmed that USPL could ablate dental hard tissue, precisely and non-thermally. In addition, the ablation depths of samples were 10μm, 20μm, and 60μm at 90 W/cm2, 180 W/cm2, and 360 W/cm2, approximately. Therefore, ablation depth by USPL depends on the average power density. USPL has the possibility that can control the precision and non-thermal ablation with depth direction by adjusting the irradiated average power density.

  9. Ultrashort pulse high repetition rate laser system for biological tissue processing

    DOEpatents

    Neev, Joseph; Da Silva, Luiz B.; Matthews, Dennis L.; Glinsky, Michael E.; Stuart, Brent C.; Perry, Michael D.; Feit, Michael D.; Rubenchik, Alexander M.

    1998-01-01

    A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.

  10. Ultrashort pulse high repetition rate laser system for biological tissue processing

    DOEpatents

    Neev, J.; Da Silva, L.B.; Matthews, D.L.; Glinsky, M.E.; Stuart, B.C.; Perry, M.D.; Feit, M.D.; Rubenchik, A.M.

    1998-02-24

    A method and apparatus are disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment. 8 figs.

  11. D-shaped fiber grating refractive index sensor induced by an ultrashort pulse laser.

    PubMed

    Liao, Changrui; Wang, Qiao; Xu, Lei; Liu, Shen; He, Jun; Zhao, Jing; Li, Zhengyong; Wang, Yiping

    2016-03-01

    The fabrication of fiber Bragg gratings was here demonstrated using ultrashort pulse laser point-by-point inscription. This is a very convenient means of creating fiber Bragg gratings with different grating periods and works by changing the translation speed of the fiber. The laser energy was first optimized in order to improve the spectral properties of the fiber gratings. Then, fiber Bragg gratings were formed into D-shaped fibers for use as refractive index sensors. A nonlinear relationship was observed between the Bragg wavelength and liquid refractive index, and a sensitivity of ∼30  nm/RIU was observed at 1.450. This shows that D-shaped fiber Bragg gratings might be used to develop promising biochemical sensors.

  12. Ultrashort pulse energy distribution for propulsion in space

    NASA Astrophysics Data System (ADS)

    Bergstue, Grant Jared

    This thesis effort focuses on the development of a novel, space-based ultrashort pulse transmission system for spacecraft. The goals of this research include: (1) ultrashort pulse transmission strategies for maximizing safety and efficiency; (2) optical transmission system requirements; (3) general system requirements including control techniques for stabilization; (4) optical system requirements for achieving effective ablative propulsion at the receiving spacecraft; and (5) ultrashort pulse transmission capabilities required for future missions in space. A key element of the research is the multiplexing device required for aligning the ultrashort pulses from multiple laser sources along a common optical axis for transmission. This strategy enables access to the higher average and peak powers required for useful missions in space.

  13. Dynamics of the Coulomb explosion of large hydrogen iodide clusters irradiated by superintense ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Krainov, V. P.; Roshchupkin, A. S.

    2001-12-01

    Dynamics of the inner and outer above-barrier ionization and of the Coulomb explosion are calculated for large hydrogen iodide clusters irradiated by superintense ultrashort laser pulses. We have found that the Coulomb forces predominate in the expansion of these clusters in comparison with the hydrodynamic forces. The energy distribution of the iodine multiple atomic ions in laser focal volume is derived. Results of our calculations are in a good agreement with the recent experimental data of Tisch et al. [Phys. Rev. A 60, 3076 (1999)].

  14. Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser

    PubMed Central

    2014-01-01

    Background Low-power ultrashort pulsed (USP) lasers operating at wavelengths of 425 nm and near infrared region have been shown to effectively inactivate viruses such as human immunodeficiency virus (HIV), M13 bacteriophage, and murine cytomegalovirus (MCMV). It was shown previously that non-enveloped, helical viruses such as M13 bacteriophage, were inactivated by a USP laser through an impulsive stimulated Raman scattering (ISRS) process. Recently, enveloped virus like MCMV has been shown to be inactivated by a USP laser via protein aggregation induced by an ISRS process. However, the inactivation mechanism for a clinically important class of viruses – non-enveloped, icosahedral viruses remains unknown. Results and discussions We have ruled out the following four possible inactivation mechanisms for non-enveloped, icosahedral viruses, namely, (1) inactivation due to ultraviolet C (UVC) photons produced by non-linear optical process of the intense, fundamental laser beam at 425 nm; (2) inactivation caused by thermal heating generated by the direct laser absorption/heating of the virion; (3) inactivation resulting from a one-photon absorption process via chromophores such as porphyrin molecules, or indicator dyes, potentially producing reactive oxygen or other species; (4) inactivation by the USP lasers in which the extremely intense laser pulse produces shock wave-like vibrations upon impact with the viral particle. We present data which support that the inactivation mechanism for non-enveloped, icosahedral viruses is the impulsive stimulated Raman scattering process. Real-time PCR experiments show that, within the amplicon size of 273 bp tested, there is no damage on the genome of MNV-1 caused by the USP laser irradiation. Conclusion We conclude that our model non-enveloped virus, MNV-1, is inactivated by the ISRS process. These studies provide fundamental knowledge on photon-virus interactions on femtosecond time scales. From the analysis of the transmission

  15. Nanoplasmonic generation of ultrashort EUV pulses

    NASA Astrophysics Data System (ADS)

    Choi, Joonhee; Lee, Dong-Hyub; Han, Seunghwoi; Park, In-Yong; Kim, Seungchul; Kim, Seung-Woo

    2012-10-01

    Ultrashort extreme-ultraviolet (EUV) light pulses are an important tool for time-resolved pump-probe spectroscopy to investigate the ultrafast dynamics of electrons in atoms and molecules. Among several methods available to generate ultrashort EUV light pulses, the nonlinear frequency upconversion process of high-harmonic generation (HHG) draws attention as it is capable of producing coherent EUV pulses with precise control of burst timing with respect to the driving near-infrared (NIR) femtosecond laser. In this report, we present and discuss our recent experimental data obtained by the plasmon-driven HHG method that generate EUV radiation by means of plasmonic nano-focusing of NIR femtosecond pulses. For experiment, metallic waveguides having a tapered hole of funnel shape inside were fabricated by adopting the focused-ion-beam process on a micro-cantilever substrate. The plasmonic field formed within the funnelwaveguides being coupled with the incident femtosecond pulse permitted intensity enhancement by a factor of ~350, which creates a hot spot of sub-wavelength size with intensities strong enough for HHG. Experimental results showed that with injection of noble gases into the funnel-waveguides, EUV radiation is generated up to wavelengths of 32 nm and 29.6 nm from Ar and Ne gas atoms, respectively. Further, it was observed that lower-order EUV harmonics are cut off in the HHG spectra by the tiny exit aperture of the funnel-waveguide.

  16. Process Properties of Electronic High Voltage Discharges Triggered by Ultra-short Pulsed Laser Filaments

    NASA Astrophysics Data System (ADS)

    Cvecek, Kristian; Gröschel, Benjamin; Schmidt, Michael

    Remote processing of metallic workpieces by techniques based on electric arc discharge or laser irradiation for joining or cutting has a long tradition and is still being intensively investigated in present-day research. In applications that require high power processing, both approaches exhibit certain advantages and disadvantages that make them specific for a given task. While several hybrid approaches exist that try to combine the benefits of both techniques, none were as successful in providing a fixed electric discharge direction as discharges triggered by plasma filaments generated by ultra-short pulsed lasers. In this work we investigate spatial and temporal aspects of laser filament guided discharges and give an upper time delay between the filament creation and the electrical build-up of a dischargeable voltage for a successful filament triggered discharge.

  17. Dislocation structure produced by an ultrashort shock pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Matsuda, Tomoki, E-mail: t-matsu@mapse.eng.osaka-u.ac.jp; Hirose, Akio; Sano, Tomokazu

    We found an ultrashort shock pulse driven by a femtosecond laser pulse on iron generates a different dislocation structure than the shock process which is on the nanosecond timescale. The ultrashort shock pulse produces a highly dense dislocation structure that varies by depth. According to transmission electron microscopy, dislocations away from the surface produce microbands via a network structure similar to a long shock process, but unlike a long shock process dislocations near the surface have limited intersections. Considering the dislocation motion during the shock process, the structure near the surface is attributed to the ultrashort shock duration. This approachmore » using an ultrashort shock pulse will lead to understanding the whole process off shock deformation by clarifying the early stage.« less

  18. Development of safe infrared gas lasers

    NASA Astrophysics Data System (ADS)

    Mainuddin; Singhal, Gaurav; Tyagi, R. K.; Maini, A. K.

    2013-04-01

    Infrared gas lasers find application in numerous civil and military areas. Such lasers are therefore being developed at different institutions around the world. However, the development of chemical infrared gas lasers such as chemical oxygen iodine lasers (COIL) involves the use of several hazardous chemicals. In order to exploit full potential of these lasers, one must take diligent care of the safety issues associated with the handling of these chemicals and the involved processes. The present paper discusses the safety aspects to be taken into account in the development of these infrared gas lasers including various detection sensors working in conjunction with a customized data acquisition system loaded with safety interlocks for safe operation. The developed safety schemes may also be implemented for CO2 gas dynamic laser (GDL) and hydrogen fluoride-deuterium fluoride (HF-DF) Laser.

  19. Tuning the frequency of ultrashort laser pulses by a cross-phase-modulation-induced shift in a photonic crystal fiber.

    PubMed

    Konorov, S O; Akimov, D A; Zheltikov, A M; Ivanov, A A; Alfimov, M V; Scalora, M

    2005-06-15

    Femtosecond pulses of fundamental Cr:forsterite laser radiation are used as a pump field to tune the frequency of copropagating second-harmonic pulses of the same laser through cross-phase modulation in a photonic crystal fiber. Sub-100-kW femtosecond pump pulses coupled into a photonic crystal fiber with an appropriate dispersion profile can shift the central frequency of the probe field by more than 100 nm, suggesting a convenient way to control propagation and spectral transformations of ultrashort laser pulses.

  20. Temporal characterization of ultrashort linearly chirped electron bunches generated from a laser wakefield accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, C. J.; Hua, J. F.; Wan, Y.

    A new method for diagnosing the temporal characteristics of ultrashort electron bunches with linear energy chirp generated from a laser wakefield accelerator is described. When the ionization-injected bunch interacts with the back of the drive laser, it is deflected and stretched along the direction of the electric field of the laser. Upon exiting the plasma, if the bunch goes through a narrow slit in front of the dipole magnet that disperses the electrons in the plane of the laser polarization, it can form a series of bunchlets that have different energies but are separated by half a laser wavelength. Sincemore » only the electrons that are undeflected by the laser go through the slit, the energy spectrum of the bunch is modulated. By analyzing the modulated energy spectrum, the shots where the bunch has a linear energy chirp can be recognized. Consequently, the energy chirp and beam current profile of those bunches can be reconstructed. Lastly, this method is demonstrated through particle-in-cell simulations and experiment.« less

  1. Interaction of intense ultrashort pulse lasers with clusters.

    NASA Astrophysics Data System (ADS)

    Petrov, George

    2007-11-01

    The last ten years have witnessed an explosion of activity involving the interaction of clusters with intense ultrashort pulse lasers. Atomic or molecular clusters are targets with unique properties, as they are halfway between solid and gases. The intense laser radiation creates hot dense plasma, which can provide a compact source of x-rays and energetic particles. The focus of this investigation is to understand the salient features of energy absorption and Coulomb explosion by clusters. The evolution of clusters is modeled with a relativistic time-dependent 3D Molecular Dynamics (MD) model [1]. The Coulomb interaction between particles is handled by a fast tree algorithm, which allows large number of particles to be used in simulations [2]. The time histories of all particles in a cluster are followed in time and space. The model accounts for ionization-ignition effects (enhancement of the laser field in the vicinity of ions) and a variety of elementary processes for free electrons and charged ions, such as optical field and collisional ionization, outer ionization and electron recapture. The MD model was applied to study small clusters (1-20 nm) irradiated by a high-intensity (10^16-10^20 W/cm^2) sub-picosecond laser pulse. We studied fundamental cluster features such as energy absorption, x-ray emission, particle distribution, average charge per atom, and cluster explosion as a function of initial cluster radius, laser peak intensity and wavelength. Simulations of novel applications, such as table-top nuclear fusion from exploding deuterium clusters [3] and high power synchrotron radiation for biological applications and imaging [4] have been performed. The application for nuclear fusion was motivated by the efficient absorption of laser energy (˜100%) and its high conversion efficiency into ion kinetic energy (˜50%), resulting in neutron yield of 10^6 neutrons/Joule laser energy. Contributors: J. Davis and A. L. Velikovich. [1] G. M. Petrov, et al Phys

  2. Novel oral applications of ultra-short laser pulses

    NASA Astrophysics Data System (ADS)

    Wieger, V.; Wernisch, J.; Wintner, E.

    2007-02-01

    In the past decades, many efforts have been made to replace mechanical tools in oral applications by various laser systems. The reasons therefore are manifold: i) Friction causes high temperatures damaging adjacent tissue. ii) Smear layers and rough surfaces are produced. iii) Size and shape of traditional tools are often unsuitable for geometrically complicated incisions and for minimum invasive treatment. iv) Mechanical damage of the remaining tissue occurs. v) Online diagnosis for feedback is not available. Different laser systems in the µs and sub-&mrgs-pulse regime, among them Erbium lasers, have been tested in the hope to overcome the mentioned drawbacks and, to some extent, they represent the current state of the art with respect to commercial and hence practical application. In the present work the applicability of scanned ultrashort pulse lasers (USPLs) for biological hard tissue as well as dental restoration material removal was tested. It is shown that cavities with features superior to mechanically treated or Erbium laser ablated cavities can be generated if appropriate scan algorithms and optimum laser parameters are matched. Smooth cavity rims, no microcracks, melting or carbonisation and precise geometry are the advantages of scanned USLP ablation. For bone treatment better healing conditions are expected as the natural structure remains unaffected by the preparation procedure. The novelty of this work is represented by a comprehensive compilation of various experimental results intended to assess the performance of USPLs. In this context, various pulse durations in the picosecond and femtosecond regime were applied to dental and bone tissue as well as dental restoration materials which is considered to be indispensable for a complete assessment. Parameters like ablation rates describing the efficiency of the ablation process, and ablation thresholds were determined - some of them for the first time - and compared to the corresponding Erbium

  3. Development of experimental techniques for the characterization of ultrashort photon pulses of extreme ultraviolet free-electron lasers

    NASA Astrophysics Data System (ADS)

    Düsterer, S.; Rehders, M.; Al-Shemmary, A.; Behrens, C.; Brenner, G.; Brovko, O.; DellAngela, M.; Drescher, M.; Faatz, B.; Feldhaus, J.; Frühling, U.; Gerasimova, N.; Gerken, N.; Gerth, C.; Golz, T.; Grebentsov, A.; Hass, E.; Honkavaara, K.; Kocharian, V.; Kurka, M.; Limberg, Th.; Mitzner, R.; Moshammer, R.; Plönjes, E.; Richter, M.; Rönsch-Schulenburg, J.; Rudenko, A.; Schlarb, H.; Schmidt, B.; Senftleben, A.; Schneidmiller, E. A.; Siemer, B.; Sorgenfrei, F.; Sorokin, A. A.; Stojanovic, N.; Tiedtke, K.; Treusch, R.; Vogt, M.; Wieland, M.; Wurth, W.; Wesch, S.; Yan, M.; Yurkov, M. V.; Zacharias, H.; Schreiber, S.

    2014-12-01

    One of the most challenging tasks for extreme ultraviolet, soft and hard x-ray free-electron laser photon diagnostics is the precise determination of the photon pulse duration, which is typically in the sub 100 fs range. Nine different methods, able to determine such ultrashort photon pulse durations, were compared experimentally at FLASH, the self-amplified spontaneous emission free-electron laser at DESY in Hamburg, in order to identify advantages and disadvantages of different methods. Radiation pulses at a wavelength of 13.5 and 24.0 nm together with the corresponding electron bunch duration were measured by indirect methods like analyzing spectral correlations, statistical fluctuations, and energy modulations of the electron bunch and also by direct methods like autocorrelation techniques, terahertz streaking, or reflectivity changes of solid state samples. In this paper, we present a comprehensive overview of the various techniques and a comparison of the individual experimental results. The information gained is of utmost importance for the future development of reliable pulse duration monitors indispensable for successful experiments with ultrashort extreme ultraviolet pulses.

  4. Shock wave acceleration of protons in inhomogeneous plasma interacting with ultrashort intense laser pulses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lecz, Zs.; Andreev, A.; Max-Born Institute, Berlin

    The acceleration of protons, triggered by solitary waves in expanded solid targets is investigated using particle-in-cell simulations. The near-critical density plasma is irradiated by ultrashort high power laser pulses, which generate the solitary wave. The transformation of this soliton into a shock wave during propagation in plasma with exponentially decreasing density profile is described analytically, which allows to obtain a scaling law for the proton energy. The high quality proton bunch with small energy spread is produced by reflection from the shock-front. According to the 2D simulations, the mechanism is stable only if the laser pulse duration is shorter thanmore » the characteristic development time of the parasitic Weibel instability.« less

  5. Mode-locking peculiarities in an all-fiber erbium-doped ring ultrashort pulse laser with a highly-nonlinear resonator

    NASA Astrophysics Data System (ADS)

    Dvoretskiy, Dmitriy A.; Sazonkin, Stanislav G.; Kudelin, Igor S.; Orekhov, Ilya O.; Pnev, Alexey B.; Karasik, Valeriy E.; Denisov, Lev K.

    2017-12-01

    Today ultrashort pulse (USP) fiber lasers are in great demand in a frequency metrology field, THz pulse spectroscopy, optical communication, quantum optics application, etc. Therefore mode-locked (ML) fiber lasers have been extensively investigated over the last decade due the number of scientific, medical and industrial applications. It should be noted, that USP fiber lasers can be treated as an ideal platform to expand future applications due to the complex ML nonlinear dynamics in a laser resonator. Up to now a series of novel ML regimes have been investigated e.g. self-similar pulses, noise-like pulses, multi-bound solitons and soliton rain generation. Recently, we have used a highly nonlinear germanosilicate fiber (with germanium oxides concentration in the core 50 mol. %) inside the resonator for more reliable and robust launching of passive mode-locking based on the nonlinear polarization evolution effect in fibers. In this work we have measured promising and stable ML regimes such as stretched pulses, soliton rain and multi-bound solitons formed in a highly-nonlinear ring laser and obtained by intracavity group velocity dispersion (GVD) variation in slightly negative region. As a result, we have obtained the low noise ultrashort pulse generation with duration < 250 fs (more than 20 bound pulses when obtained multi-bound soliton generation with intertemporal width 5 ps) at a repetition rate 11.3 MHz (with signal-to-noise ratio at fundamental frequency > 59 dB) and relative intensity noise <-101 dBc / Hz.

  6. Comparison of retina damage thresholds simulating the femtosecond-laser in situ keratomileusis (fs-LASIK) process with two laser systems in the CW- and fs-regime

    NASA Astrophysics Data System (ADS)

    Sander, M.; Minet, O.; Zabarylo, U.; Müller, M.; Tetz, M. R.

    2012-04-01

    The femtosecond-laser in situ keratomileusis procedure affords the opportunity to correct ametropia by cutting transparent corneal tissue with ultra-short laser pulses. Thereby the tissue cut is generated by a laser-induced optical breakdown in the cornea with ultra-short laser pulses in the near-infrared range. Compared to standard procedures such as photorefractive keratectomy and laser in-situ keratomileusis with the excimer laser, where the risk potential for the eye is low due to the complete absorption of ultraviolet irradiation from corneal tissue, only a certain amount of the pulse energy is deposited in the cornea during the fs-LASIK process. The remaining energy propagates through the eye and interacts with the retina and the strong absorbing tissue layers behind. The objective of the presented study was to determine and compare the retina damage thresholds during the fs-LASIK process simulated with two various laser systems in the CW- and fs-regime.

  7. Ultra-short pulse delivery at high average power with low-loss hollow core fibers coupled to TRUMPF's TruMicro laser platforms for industrial applications

    NASA Astrophysics Data System (ADS)

    Baumbach, S.; Pricking, S.; Overbuschmann, J.; Nutsch, S.; Kleinbauer, J.; Gebs, R.; Tan, C.; Scelle, R.; Kahmann, M.; Budnicki, A.; Sutter, D. H.; Killi, A.

    2017-02-01

    Multi-megawatt ultrafast laser systems at micrometer wavelength are commonly used for material processing applications, including ablation, cutting and drilling of various materials or cleaving of display glass with excellent quality. There is a need for flexible and efficient beam guidance, avoiding free space propagation of light between the laser head and the processing unit. Solid core step index fibers are only feasible for delivering laser pulses with peak powers in the kW-regime due to the optical damage threshold in bulk silica. In contrast, hollow core fibers are capable of guiding ultra-short laser pulses with orders of magnitude higher peak powers. This is possible since a micro-structured cladding confines the light within the hollow core and therefore minimizes the spatial overlap between silica and the electro-magnetic field. We report on recent results of single-mode ultra-short pulse delivery over several meters in a lowloss hollow core fiber packaged with industrial connectors. TRUMPF's ultrafast TruMicro laser platforms equipped with advanced temperature control and precisely engineered opto-mechanical components provide excellent position and pointing stability. They are thus perfectly suited for passive coupling of ultra-short laser pulses into hollow core fibers. Neither active beam launching components nor beam trackers are necessary for a reliable beam delivery in a space and cost saving packaging. Long term tests with weeks of stable operation, excellent beam quality and an overall transmission efficiency of above 85 percent even at high average power confirm the reliability for industrial applications.

  8. Quasi-matched propagation of an ultrashort and intense laser pulse in a plasma channel

    NASA Astrophysics Data System (ADS)

    Benedetti, Carlo; Schroeder, Carl; Esarey, Eric; Leemans, Wim

    2011-10-01

    The propagation of an ultrashort and relativistically-intense laser pulse in a preformed parabolic plasma channel is investigated. The nonlinear paraxial wave equation is solved both analytically and numerically. Numerical solutions are obtained using the 2D cylindrical, envelope, ponderomotive, hybrid PIC/fluid code INF&RNO, recently developed at LBNL. For an arbitrary laser pulse profile with a given power for each longitudinal slice (less then the critical power for self-focusing), we determine the laser intensity distribution ensuring matched propagation in the channel, neglecting non-paraxial effects (self-steepening, red-shifting, etc.). Similarly, in the case of a Gaussian pulse profile, we determine the optimal channel depth yielding a quasi-matched laser propagation, including the plasma density modification induced by the laser-pulse. The analytical results obtained for both cases in the weakly-relativistic intensity regime are presented and validated through comparison with numerical simulations. Work supported by the Office of Science, Office of High Energy Physics, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.

  9. Graphics-processing-unit-accelerated finite-difference time-domain simulation of the interaction between ultrashort laser pulses and metal nanoparticles

    NASA Astrophysics Data System (ADS)

    Nikolskiy, V. P.; Stegailov, V. V.

    2018-01-01

    Metal nanoparticles (NPs) serve as important tools for many modern technologies. However, the proper microscopic models of the interaction between ultrashort laser pulses and metal NPs are currently not very well developed in many cases. One part of the problem is the description of the warm dense matter that is formed in NPs after intense irradiation. Another part of the problem is the description of the electromagnetic waves around NPs. Description of wave propagation requires the solution of Maxwell’s equations and the finite-difference time-domain (FDTD) method is the classic approach for solving them. There are many commercial and free implementations of FDTD, including the open source software that supports graphics processing unit (GPU) acceleration. In this report we present the results on the FDTD calculations for different cases of the interaction between ultrashort laser pulses and metal nanoparticles. Following our previous results, we analyze the efficiency of the GPU acceleration of the FDTD algorithm.

  10. Investigation of Temperature Change under Influence of Ultrashort Laser Pulses Taking into Account Relaxation Properties of Materials

    NASA Astrophysics Data System (ADS)

    Eremin, A. V.; Kudinov, V. A.; Stefanyuk, E. V.; Kudinov, I. V.

    2018-03-01

    By using the modified Fourier law’s formula considering the relaxation of heat flow and temperature gradient, a mathematical model of the local non-equilibrium process of plate heating with ultrashort laser pulses was developed. The research showed that consideration of non-locality results in the delayed plate heat up irrespective of the laser radiation flow intensity. It was also shown that in consideration of the relaxation phenomena, the boundary conditions may not be fulfilled immediately – they may be set only within a definite range of the initial time.

  11. Infrared laser system

    DOEpatents

    Cantrell, Cyrus D.; Carbone, Robert J.; Cooper, Ralph S.

    1977-01-01

    An infrared laser system and method for isotope separation may comprise a molecular gas laser oscillator to produce a laser beam at a first wavelength, Raman spin flip means for shifting the laser to a second wavelength, a molecular gas laser amplifier to amplify said second wavelength laser beam to high power, and optical means for directing the second wavelength, high power laser beam against a desired isotope for selective excitation thereof in a mixture with other isotopes. The optical means may include a medium which shifts the second wavelength high power laser beam to a third wavelength, high power laser beam at a wavelength coincidental with a corresponding vibrational state of said isotope and which is different from vibrational states of other isotopes in the gas mixture.

  12. Infrared laser system

    DOEpatents

    Cantrell, Cyrus D.; Carbone, Robert J.; Cooper, Ralph

    1982-01-01

    An infrared laser system and method for isotope separation may comprise a molecular gas laser oscillator to produce a laser beam at a first wavelength, Raman spin flip means for shifting the laser to a second wavelength, a molecular gas laser amplifier to amplify said second wavelength laser beam to high power, and optical means for directing the second wavelength, high power laser beam against a desired isotope for selective excitation thereof in a mixture with other isotopes. The optical means may include a medium which shifts the second wavelength high power laser beam to a third wavelength, high power laser beam at a wavelength coincidental with a corresponding vibrational state of said isotope and which is different from vibrational states of other isotopes in the gas mixture.

  13. Electric field detection of phase-locked near-infrared pulses using photoconductive antenna.

    PubMed

    Katayama, I; Akai, R; Bito, M; Matsubara, E; Ashida, M

    2013-07-15

    We have demonstrated that a photoconductive antenna gated with 5-fs ultrashort laser pulses can detect electric field transients of near-infrared pulses at least up to 180 THz. Measured sensitivity spectrum of the antenna shows a good agreement with a simple calculation, demonstrating the promising capability of the antenna to near infrared spectroscopy. Using this setup, near-infrared time-domain spectroscopy and characterization of phase controlled near-infrared pulses are demonstrated. Observed absorption spectrum of a polystyrene film and complex refractive index dispersion of a fused silica plate both agree well with those obtained by the conventional methods.

  14. Optical field ionization of atoms and ions using ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Fittinghoff, D. N.

    1993-12-01

    This dissertation research is an investigation of the strong optical field ionization of atoms and ions by 120-fs, 614-run laser pulses and 130-fs, 800-nm laser pulses. The experiments have shown ionization that is enhanced above the predictions of sequential tunneling models for He(+2), Ne(+2), and Ar(+2). The ion yields for He(+1), Ne(sup +1) and Ar(sup +1) agree well with the theoretical predictions of optical tunneling models. Investigation of the polarization dependence of the ionization indicates that the enhancements are consistent with a nonsequential ionization mechanism in which the linearly polarized field drives the electron wavefunction back toward the ion core and causes double ionization through inelastic e-2e scattering. These investigations have initiated a number of other studies by other groups and are of current scientific interest in the fields of high-irradiance laser-matter interactions and production of high-density plasmas. This work involved the following: (1) Understanding the characteristic nature of the ion yields produced by tunneling ionization through investigation of analytic solutions for tunneling at optical frequencies. (2) Extensive characterization of the pulses produced by 614-nm and 800-ran ultrashort pulse lasers. Absolute calibration of the irradiance scale produced shows the practicality of the inverse problem--measuring peak laser irradiance using ion yields. (3) Measuring the ion yields for three noble gases using linear, circular and elliptical polarizations of laser pulses at 614-nm and 800-nm. The measurements are some of the first measurements for pulse widths as low as 120-fs.

  15. Active mode locking of quantum cascade lasers in an external ring cavity.

    PubMed

    Revin, D G; Hemingway, M; Wang, Y; Cockburn, J W; Belyanin, A

    2016-05-05

    Stable ultrashort light pulses and frequency combs generated by mode-locked lasers have many important applications including high-resolution spectroscopy, fast chemical detection and identification, studies of ultrafast processes, and laser metrology. While compact mode-locked lasers emitting in the visible and near infrared range have revolutionized photonic technologies, the systems operating in the mid-infrared range where most gases have their strong absorption lines, are bulky and expensive and rely on nonlinear frequency down-conversion. Quantum cascade lasers are the most powerful and versatile compact light sources in the mid-infrared range, yet achieving their mode-locked operation remains a challenge, despite dedicated effort. Here we report the demonstration of active mode locking of an external-cavity quantum cascade laser. The laser operates in the mode-locked regime at room temperature and over the full dynamic range of injection currents.

  16. Active mode locking of quantum cascade lasers in an external ring cavity

    PubMed Central

    Revin, D. G.; Hemingway, M.; Wang, Y.; Cockburn, J. W.; Belyanin, A.

    2016-01-01

    Stable ultrashort light pulses and frequency combs generated by mode-locked lasers have many important applications including high-resolution spectroscopy, fast chemical detection and identification, studies of ultrafast processes, and laser metrology. While compact mode-locked lasers emitting in the visible and near infrared range have revolutionized photonic technologies, the systems operating in the mid-infrared range where most gases have their strong absorption lines, are bulky and expensive and rely on nonlinear frequency down-conversion. Quantum cascade lasers are the most powerful and versatile compact light sources in the mid-infrared range, yet achieving their mode-locked operation remains a challenge, despite dedicated effort. Here we report the demonstration of active mode locking of an external-cavity quantum cascade laser. The laser operates in the mode-locked regime at room temperature and over the full dynamic range of injection currents. PMID:27147409

  17. Lunar laser ranging in infrared at the Grasse laser station

    NASA Astrophysics Data System (ADS)

    Courde, C.; Torre, J. M.; Samain, E.; Martinot-Lagarde, G.; Aimar, M.; Albanese, D.; Exertier, P.; Fienga, A.; Mariey, H.; Metris, G.; Viot, H.; Viswanathan, V.

    2017-06-01

    For many years, lunar laser ranging (LLR) observations using a green wavelength have suffered an inhomogeneity problem both temporally and spatially. This paper reports on the implementation of a new infrared detection at the Grasse LLR station and describes how infrared telemetry improves this situation. Our first results show that infrared detection permits us to densify the observations and allows measurements during the new and the full Moon periods. The link budget improvement leads to homogeneous telemetric measurements on each lunar retro-reflector. Finally, a surprising result is obtained on the Lunokhod 2 array which attains the same efficiency as Lunokhod 1 with an infrared laser link, although those two targets exhibit a differential efficiency of six with a green laser link.

  18. Targeted disruption of deep-lying neocortical microvessels in rat using ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Nishimura, Nozomi; Schaffer, Christopher B.; Friedman, Beth; Tsai, Philbert S.; Lyden, Patrick D.; Kleinfeld, David

    2004-06-01

    The study of neurovascular diseases such as vascular dementia and stroke require novel models of targeted vascular disruption in the brain. We describe a model of microvascular disruption in rat neocortex that uses ultrashort laser pulses to induce localized injury to specific targeted microvessels and uses two-photon microscopy to monitor and guide the photodisruption process. In our method, a train of high-intensity, 100-fs laser pulses is tightly focused into the lumen of a blood vessel within the upper 500 μm of cortex. Photodisruption induced by these laser pulses creates injury to a single vessel located at the focus of the laser, leaving the surrounding tissue intact. This photodisruption results in three modalities of localized vascular injury. At low power, blood plasma extravasation can be induced. The vessel itself remains intact, while serum is extravasated into the intercellular space. Localized ischemia caused by an intravascular clot results when the photodisruption leads to a brief disturbance of the vascular walls that initiates an endogenous clotting cascade. The formation of a localized thrombus stops the blood flow at the location of the photodisruption. A hemorrhage, defined as a large extravasation of blood including plasma and red blood cells, results when higher laser power is used. The targeted vessel does not remain intact.

  19. Nanosurgery with near-infrared 12-femtosecond and picosecond laser pulses

    NASA Astrophysics Data System (ADS)

    Uchugonova, Aisada; Zhang, Huijing; Lemke, Cornelius; König, Karsten

    2011-03-01

    Laser-assisted surgery based on multiphoton absorption of NIR laser light has great potential for high precision surgery at various depths within the cells and tissues. Clinical applications include refractive surgery (fs-LASIK). The non-contact laser method also supports contamination-free cell nanosurgery. Here we apply femtosecond laser scanning microscopes for sub-100 nm surgery of human cells and metaphase chromosomes. A mode-locked 85 MHz Ti:Sapphire laser with an M-shaped ultrabroad band spectrum (maxima: 770 nm/830 nm) with an in situ pulse duration at the target ranging from 12 femtoseconds up to 3 picoseconds was employed. The effects of laser nanoprocessing in cells and chromosomes have been quantified by atomic force microscopy (AFM) and electron microscopy. These studies demonstrate the potential of extreme ultrashort femtosecond laser pulses at low mean milliwatt powers for sub-100 nm surgery.

  20. Precise ablation of dental hard tissues with ultra-short pulsed lasers. Preliminary exploratory investigation on adequate laser parameters.

    PubMed

    Bello-Silva, Marina Stella; Wehner, Martin; Eduardo, Carlos de Paula; Lampert, Friedrich; Poprawe, Reinhart; Hermans, Martin; Esteves-Oliveira, Marcella

    2013-01-01

    This study aimed to evaluate the possibility of introducing ultra-short pulsed lasers (USPL) in restorative dentistry by maintaining the well-known benefits of lasers for caries removal, but also overcoming disadvantages, such as thermal damage of irradiated substrate. USPL ablation of dental hard tissues was investigated in two phases. Phase 1--different wavelengths (355, 532, 1,045, and 1,064 nm), pulse durations (picoseconds and femtoseconds) and irradiation parameters (scanning speed, output power, and pulse repetition rate) were assessed for enamel and dentin. Ablation rate was determined, and the temperature increase measured in real time. Phase 2--the most favorable laser parameters were evaluated to correlate temperature increase to ablation rate and ablation efficiency. The influence of cooling methods (air, air-water spray) on ablation process was further analyzed. All parameters tested provided precise and selective tissue ablation. For all lasers, faster scanning speeds resulted in better interaction and reduced temperature increase. The most adequate results were observed for the 1064-nm ps-laser and the 1045-nm fs-laser. Forced cooling caused moderate changes in temperature increase, but reduced ablation, being considered unnecessary during irradiation with USPL. For dentin, the correlation between temperature increase and ablation efficiency was satisfactory for both pulse durations, while for enamel, the best correlation was observed for fs-laser, independently of the power used. USPL may be suitable for cavity preparation in dentin and enamel, since effective ablation and low temperature increase were observed. If adequate laser parameters are selected, this technique seems to be promising for promoting the laser-assisted, minimally invasive approach.

  1. [Infrared spectroscopy based on quantum cascade lasers].

    PubMed

    Wen, Zhong-Quan; Chen, Gang; Peng, Chen; Yuan, Wei-Qing

    2013-04-01

    Quantum cascade lasers (QCLs) are promising infrared coherent sources. Thanks to the quantum theory and band-gap engineering, QCL can access the wavelength in the range from 3 to 100 microm. Since the fingerprint spectrum of most gases are located in the mid-infrared range, mid-infrared quantum cascade laser based gas sensing technique has become the research focus world wide because of its high power, narrow linewidth and fast scanning. Recent progress in the QCL technology leads to a great improvement in laser output power and efficiency, which stimulates a fast development in the infrared laser spectroscopy. The present paper gives a broad review on the QCL based spectroscopy techniques according to their working principles. A discussion on their applications in gas sensing and explosive detecting is also given at the end of the paper.

  2. Bibliography of Soviet Laser Developments, Number 81, January-February 1986

    DTIC Science & Technology

    1987-04-24

    Lasers , Liquid Lasers ; Gas Lasers ; Chemical Lasers , Laser Components Nonlinear Optics, Spectroscopy of Laser Materials, Ultrashort Pulse Generation...spectroscopy of laser materials; ultrashort pulse generation; theoretical aspects of advanced lasers ; and general laser theory. Laser applications are...28 6. Acoustic Interaction ................ 28 G. Spectroscopy of Laser Materials ......... 28 H. Ultrashort

  3. Bibliography of Soviet Laser Developments, Number 44 November - December 1979.

    DTIC Science & Technology

    1980-08-13

    Laser Materials, Ultrashort Pulse Generation, X-ray Lasers , Gamma Lasers , Laser Theory, Laser Biological Effects, Laser Communications, Laser Beam... lasers ; components; nonlinear optics; spectroscopy of laser materials; ultrashort pulse generation; theoretical aspects of advanced lasers ; and...and V.P. Feshchenko (51). Stimulated Raman scattering in absorbing media during pumping by ultrashort laser

  4. Comparative hazard evaluation of near-infrared diode lasers.

    PubMed

    Marshall, W J

    1994-05-01

    Hazard evaluation methods from various laser protection standards differ when applied to extended-source, near-infrared lasers. By way of example, various hazard analyses are applied to laser training systems, which incorporate diode lasers, specifically those that assist in training military or law enforcement personnel in the proper use of weapons by simulating actual firing by the substitution of a beam of near-infrared energy for bullets. A correct hazard evaluation of these lasers is necessary since simulators are designed to be directed toward personnel during normal use. The differences among laser standards are most apparent when determining the hazard class of a laser. Hazard classification is based on a comparison of the potential exposures with the maximum permissible exposures in the 1986 and 1993 versions of the American National Standard for the Safe Use of Lasers, Z136.1, and the accessible emission limits of the federal laser product performance standard. Necessary safety design features of a particular system depend on the hazard class. The ANSI Z136.1-1993 standard provides a simpler and more accurate hazard assessment of low-power, near-infrared, diode laser systems than the 1986 ANSI standard. Although a specific system is evaluated, the techniques described can be readily applied to other near-infrared lasers or laser training systems.

  5. Measurement and compensation schemes for the pulse front distortion of ultra-intensity ultra-short laser pulses

    NASA Astrophysics Data System (ADS)

    Wu, Fenxiang; Xu, Yi; Yu, Linpeng; Yang, Xiaojun; Li, Wenkai; Lu, Jun; Leng, Yuxin

    2016-11-01

    Pulse front distortion (PFD) is mainly induced by the chromatic aberration in femtosecond high-peak power laser systems, and it can temporally distort the pulse in the focus and therefore decrease the peak intensity. A novel measurement scheme is proposed to directly measure the PFD of ultra-intensity ultra-short laser pulses, which can work not only without any extra struggle for the desired reference pulse, but also largely reduce the size of the required optical elements in measurement. The measured PFD in an experimental 200TW/27fs laser system is in good agreement with the calculated result, which demonstrates the validity and feasibility of this method effectively. In addition, a simple compensation scheme based on the combination of concave lens and parabolic lens is also designed and proposed to correct the PFD. Based on the theoretical calculation, the PFD of above experimental laser system can almost be completely corrected by using this compensator with proper parameters.

  6. Bibliography of Soviet Laser Developments, Number 85, September - October 1986.

    DTIC Science & Technology

    1987-11-01

    Ultrashort Pulse Generation, Laser Crystal Growing, Free Electron Lasers , Laser Theory, Laser Biological Effects, Laser Communications, Laser ...liquid, gas, and chemical lasers ; components; nonlinear optics; spectroscopy of laser materials; ultrashort pulse generation; crystal growing; theoretical...30 5. Self-focusing 30 6. Acoustic Interaction ................ 30 G. Spectroscopy of Laser Materials ......... 33 H. Ultrashort

  7. Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment

    NASA Astrophysics Data System (ADS)

    Tsen, Shaw-Wei David; Donthi, Nisha; La, Victor; Hsieh, Wen-Han; Li, Yen-Der; Knoff, Jayne; Chen, Alexander; Wu, Tzyy-Choou; Hung, Chien-Fu; Achilefu, Samuel; Tsen, Kong-Thon

    2015-05-01

    There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic inactivated vaccines is lacking. Conventional pathogen inactivation methods such as formalin, heat, ultraviolet light, and gamma rays cause structural alterations in vaccines that lead to reduced neutralizing antibody specificity, and in some cases, disastrous T helper type 2-mediated immune pathology. We have evaluated the potential of a visible ultrashort pulsed (USP) laser method to generate safe and immunogenic WIV vaccines without adjuvants. Specifically, we demonstrate that vaccination of mice with laser-inactivated H1N1 influenza virus at about a 10-fold lower dose than that required using conventional formalin-inactivated influenza vaccines results in protection against lethal H1N1 challenge in mice. The virus, inactivated by the USP laser irradiation, has been shown to retain its surface protein structure through hemagglutination assay. Unlike conventional inactivation methods, laser treatment did not generate carbonyl groups in protein, thereby reducing the risk of adverse vaccine-elicited T helper type 2 responses. Therefore, USP laser treatment is an attractive potential strategy to generate WIV vaccines with greater potency and safety than vaccines produced by current inactivation techniques.

  8. Plasma-driven ultrashort bunch diagnostics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dornmair, I.; Schroeder, C. B.; Floettmann, K.

    2016-06-10

    Ultrashort electron bunches are crucial for an increasing number of applications, however, diagnosing their longitudinal phase space remains a challenge. We propose a new method that harnesses the strong electric fields present in a laser driven plasma wakefield. By transversely displacing driver laser and witness bunch, a streaking field is applied to the bunch. This field maps the time information to a transverse momentum change and, consequently, to a change of transverse position. We illustrate our method with simulations where we achieve a time resolution in the attosecond range.

  9. Fabrication of amorphous micro-ring arrays in crystalline silicon using ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Fuentes-Edfuf, Yasser; Garcia-Lechuga, Mario; Puerto, Daniel; Florian, Camilo; Garcia-Leis, Adianez; Sanchez-Cortes, Santiago; Solis, Javier; Siegel, Jan

    2017-05-01

    We demonstrate a simple way to fabricate amorphous micro-rings in crystalline silicon using direct laser writing. This method is based on the fact that the phase of a thin surface layer can be changed into the amorphous phase by irradiation with a few ultrashort laser pulses (800 nm wavelength and 100 fs duration). Surface-depressed amorphous rings with a central crystalline disk can be fabricated without the need for beam shaping, featuring attractive optical, topographical, and electrical properties. The underlying formation mechanism and phase change pathway have been investigated by means of fs-resolved microscopy, identifying fluence-dependent melting and solidification dynamics of the material as the responsible mechanism. We demonstrate that the lateral dimensions of the rings can be scaled and that the rings can be stitched together, forming extended arrays of structures not limited to annular shapes. This technique and the resulting structures may find applications in a variety of fields such as optics, nanoelectronics, and mechatronics.

  10. High-throughput machining using high average power ultrashort pulse lasers and ultrafast polygon scanner

    NASA Astrophysics Data System (ADS)

    Schille, Joerg; Schneider, Lutz; Streek, André; Kloetzer, Sascha; Loeschner, Udo

    2016-03-01

    In this paper, high-throughput ultrashort pulse laser machining is investigated on various industrial grade metals (Aluminium, Copper, Stainless steel) and Al2O3 ceramic at unprecedented processing speeds. This is achieved by using a high pulse repetition frequency picosecond laser with maximum average output power of 270 W in conjunction with a unique, in-house developed two-axis polygon scanner. Initially, different concepts of polygon scanners are engineered and tested to find out the optimal architecture for ultrafast and precision laser beam scanning. Remarkable 1,000 m/s scan speed is achieved on the substrate, and thanks to the resulting low pulse overlap, thermal accumulation and plasma absorption effects are avoided at up to 20 MHz pulse repetition frequencies. In order to identify optimum processing conditions for efficient high-average power laser machining, the depths of cavities produced under varied parameter settings are analyzed and, from the results obtained, the characteristic removal values are specified. The maximum removal rate is achieved as high as 27.8 mm3/min for Aluminium, 21.4 mm3/min for Copper, 15.3 mm3/min for Stainless steel and 129.1 mm3/min for Al2O3 when full available laser power is irradiated at optimum pulse repetition frequency.

  11. Practical issues in ultrashort-laser-pulse measurement using frequency-resolved optical gating

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DeLong, K.W.; Fittinghoff, D.N.; Trebino, R.

    1996-07-01

    The authors explore several practical experimental issues in measuring ultrashort laser pulses using the technique of frequency-resolved optical gating (FROG). They present a simple method for checking the consistency of experimentally measured FROG data with the independently measured spectrum and autocorrelation of the pulse. This method is a powerful way of discovering systematic errors in FROG experiments. They show how to determine the optimum sampling rate for FROG and show that this satisfies the Nyquist criterion for the laser pulse. They explore the low- and high-power limits to FROG and determine that femtojoule operation should be possible, while the effectsmore » of self-phase modulation limit the highest signal efficiency in FROG to 1%. They also show quantitatively that the temporal blurring due to a finite-thickness medium in single-shot geometries does not strongly limit the FROG technique. They explore the limiting time-bandwidth values that can be represented on a FROG trace of a given size. Finally, they report on a new measure of the FROG error that improves convergence in the presence of noise.« less

  12. Infrared laser spectroscopic trace gas sensing

    NASA Astrophysics Data System (ADS)

    Sigrist, Markus

    2016-04-01

    Chemical sensing and analyses of gas samples by laser spectroscopic methods are attractive owing to several advantages such as high sensitivity and specificity, large dynamic range, multi-component capability, and lack of pretreatment or preconcentration procedures. The preferred wavelength range comprises the fundamental molecular absorption range in the mid-infared between 3 and 15 μm, whereas the near-infrared range covers the (10-100 times weaker) higher harmonics and combination bands. The availability of near-infrared and, particularly, of broadly tunable mid-infrared sources like external cavity quantum cascade lasers (EC-QCLs), interband cascade lasers (ICLs), difference frequency generation (DFG), optical parametric oscillators (OPOs), recent developments of diode-pumped lead salt semiconductor lasers, of supercontinuum sources or of frequency combs have eased the implementation of laser-based sensing devices. Sensitive techniques for molecular absorption measurements include multipass absorption, various configurations of cavity-enhanced techniques such as cavity ringdown (CRD), or of photoacoustic spectroscopy (PAS) including quartz-enhanced (QEPAS) or cantilever-enhanced (CEPAS) techniques. The application requirements finally determine the optimum selection of laser source and detection scheme. In this tutorial talk I shall discuss the basic principles, present various experimental setups and illustrate the performance of selected systems for chemical sensing of selected key atmospheric species. Applications include an early example of continuous vehicle emission measurements with a mobile CO2-laser PAS system [1]. The fast analysis of C1-C4 alkanes at sub-ppm concentrations in gas mixtures is of great interest for the petrochemical industry and was recently achieved with a new type of mid-infrared diode-pumped piezoelectrically tuned lead salt vertical external cavity surface emitting laser (VECSEL) [2]. Another example concerns measurements on short

  13. Sub-wavelength ripples in fused silica after irradiation of the solid/liquid interface with ultrashort laser pulses.

    PubMed

    Böhme, R; Vass, C; Hopp, B; Zimmer, K

    2008-12-10

    Laser-induced backside wet etching (LIBWE) is performed using ultrashort 248 nm laser pulses with a pulse duration of 600 fs to obtain sub-wavelength laser-induced periodic surface structures (LIPSS) on the back surface of fused silica which is in contact with a 0.5 mol l(-1) solution of pyrene in toluene. The LIPSS are strictly one-dimensional patterns, oriented parallel to the polarization of the laser radiation, and have a constant period of about 140 nm at all applied laser fluences (0.33-0.84 J cm(-2)) and pulse numbers (50-1000 pulses). The LIPSS amplitude varies due to the inhomogeneous fluence in the laser spot. The LIPSS are examined with scanning electron microscopy (SEM) and atomic force microscopy (AFM). Their power spectral density (PSD) distribution is analysed at a measured area of 10 µm × 10 µm. The good agreement of the measured and calculated LIPSS periods strongly supports a mechanism based on the interference of surface-scattered and incident waves.

  14. ICPP: Relativistic Plasma Physics with Ultra-Short High-Intensity Laser Pulses

    NASA Astrophysics Data System (ADS)

    Meyer-Ter-Vehn, Juergen

    2000-10-01

    Recent progress in generating ultra-short high-intensity laser pulses has opened a new branch of relativistic plasma physics, which is discussed in this talk in terms of particle-in-cell (PIC) simulations. These pulses create small plasma volumes of high-density plasma with plasma fields above 10^12 V/m and 10^8 Gauss. At intensities beyond 10^18 W/cm^2, now available from table-top systems, they drive relativistic electron currents in self-focussing plasma channels. These currents are close to the Alfven limit and allow to study relativistic current filamentation. A most remarkable feature is the generation of well collimated relativistic electron beams emerging from the channels with energies up to GeV. In dense matter they trigger cascades of gamma-rays, e^+e^- pairs, and a host of nuclear and particle processes. One of the applications may be fast ignition of compressed inertial fusion targets. Above 10^23 W/cm^2, expected to be achieved in the future, solid-density matter becomes relativistically transparent for optical light, and the acceleration of protons to multi-GeV energies is predicted in plasma layers less than 1 mm thick. These results open completely new perspectives for plasma-based accelerator schemes. Three-dimensional PIC simulations turn out to be the superior tool to explore the relativistic plasma kinetics at such intensities. Results obtained with the VLPL code [1] are presented. Different mechanisms of particle acceleration are discussed. Both laser wakefield and direct laser acceleration in plasma channels (by a mechanism similar to inverse free electron lasers) have been identified. The latter describes recent MPQ experimental results. [1] A. Pukhov, J. Plasma Physics 61, 425 - 433 (1999): Three-dimensional electromagnetic relativistic particle-in-cell code VLPL (Virtual Laser Plasma Laboratory).

  15. Comprehensive studies of ultrashort laser pulse ablation of tin target at terawatt power

    NASA Astrophysics Data System (ADS)

    Elsied, Ahmed M.; Diwakar, Prasoon K.; Hassanein, Ahmed

    2018-01-01

    The fundamental properties of ultrashort laser interactions with metals using up to terawatt power were comprehensively studied, i.e., specifically mass ablation, nanoparticle formation, and ion dynamics using multitude of diagnostic techniques. Results of this study can be useful in many fields of research including spectroscopy, micromachining, thin film fabrication, particle acceleration, physics of warm dense matter, and equation-of-state determination. A Ti:Sapphire femtosecond laser system (110 mJ maximum energy, 40 fs, 800 nm, P-polarized, single pulse mode) was used, which delivered up to 3 terawatt laser power to ablate 1 mm tin film in vacuum. The experimental analysis includes the effect of the incident laser fluence on the ablated mass, size of the ablated area, and depth of ablation using white light profilometer. Atomic force microscope was used to measure the emitted particles size distribution at different laser fluence. Faraday cup (FC) detector was used to analyze the emitted ions flux by measuring the velocity, and the total charge of the emitted ions. The study shows that the size of emitted particles follows log-normal distribution with peak shifts depending on incident laser fluence. The size of the ablated particles ranges from 20 to 80 nm. The nanoparticles deposited on the wafer tend to aggregate and to be denser as the incident laser fluence increases as shown by AFM images. Laser ablation depth was found to increase logarithmically with laser fluence then leveling off at laser fluence > 400 J/cm2. The total ablated mass tends to increase logarithmically with laser fluence up to 60 J/cm2 while, increases gradually at higher fluence due to the increase in the ablated area. The measured ion emitted flux shows a linear dependence on laser fluence with two distinct regimes. Strong dependence on laser fluence was observed at fluences < 350 J/cm2. Also, a slight enhancement in ion velocity was observed with increasing laser fluence up to 350 J

  16. High Resolution Frequency Measurements of Far-Infrared Laser Lines

    DTIC Science & Technology

    2010-04-01

    1 High Resolution Frequency Measurements of Far-Infrared Laser Lines Elizabeth J. Ehasz, Thomas M. Goyette, Robert H. Giles and William E. Nixon...Abstract—The frequency of four previously reported far- infrared laser lines have been measured to an accuracy of 100 kHz. These laser lines were measured ... frequencies measured here and the listed frequencies for these laser lines ranged from 59 MHz to 3.9 GHz. Index Terms—FIR Laser, Gas Laser, Molecular

  17. Atomistic simulations of ultra-short pulse laser ablation of aluminum: validity of the Lambert-Beer law

    NASA Astrophysics Data System (ADS)

    Eisfeld, Eugen; Roth, Johannes

    2018-05-01

    Based on hybrid molecular dynamics/two-temperature simulations, we study the validity of the application of Lambert-Beer's law, which is conveniently used in various modeling approaches of ultra-short pulse laser ablation of metals. The method is compared to a more rigorous treatment, which involves solving the Helmholtz wave equation for different pulse durations ranging from 100 fs to 5 ps and a wavelength of 800 nm. Our simulations show a growing agreement with increasing pulse durations, and we provide appropriate optical parameters for all investigated pulse durations.

  18. Characterizing Far-infrared Laser Emissions and the Measurement of Their Frequencies

    PubMed Central

    Jackson, Michael; Zink, Lyndon R.

    2015-01-01

    The generation and subsequent measurement of far-infrared radiation has found numerous applications in high-resolution spectroscopy, radio astronomy, and Terahertz imaging. For about 45 years, the generation of coherent, far-infrared radiation has been accomplished using the optically pumped molecular laser. Once far-infrared laser radiation is detected, the frequencies of these laser emissions are measured using a three-laser heterodyne technique. With this technique, the unknown frequency from the optically pumped molecular laser is mixed with the difference frequency between two stabilized, infrared reference frequencies. These reference frequencies are generated by independent carbon dioxide lasers, each stabilized using the fluorescence signal from an external, low pressure reference cell. The resulting beat between the known and unknown laser frequencies is monitored by a metal-insulator-metal point contact diode detector whose output is observed on a spectrum analyzer. The beat frequency between these laser emissions is subsequently measured and combined with the known reference frequencies to extrapolate the unknown far-infrared laser frequency. The resulting one-sigma fractional uncertainty for laser frequencies measured with this technique is ± 5 parts in 107. Accurately determining the frequency of far-infrared laser emissions is critical as they are often used as a reference for other measurements, as in the high-resolution spectroscopic investigations of free radicals using laser magnetic resonance. As part of this investigation, difluoromethane, CH2F2, was used as the far-infrared laser medium. In all, eight far-infrared laser frequencies were measured for the first time with frequencies ranging from 0.359 to 1.273 THz. Three of these laser emissions were discovered during this investigation and are reported with their optimal operating pressure, polarization with respect to the CO2 pump laser, and strength. PMID:26709957

  19. Characterizing Far-infrared Laser Emissions and the Measurement of Their Frequencies.

    PubMed

    Jackson, Michael; Zink, Lyndon R

    2015-12-18

    The generation and subsequent measurement of far-infrared radiation has found numerous applications in high-resolution spectroscopy, radio astronomy, and Terahertz imaging. For about 45 years, the generation of coherent, far-infrared radiation has been accomplished using the optically pumped molecular laser. Once far-infrared laser radiation is detected, the frequencies of these laser emissions are measured using a three-laser heterodyne technique. With this technique, the unknown frequency from the optically pumped molecular laser is mixed with the difference frequency between two stabilized, infrared reference frequencies. These reference frequencies are generated by independent carbon dioxide lasers, each stabilized using the fluorescence signal from an external, low pressure reference cell. The resulting beat between the known and unknown laser frequencies is monitored by a metal-insulator-metal point contact diode detector whose output is observed on a spectrum analyzer. The beat frequency between these laser emissions is subsequently measured and combined with the known reference frequencies to extrapolate the unknown far-infrared laser frequency. The resulting one-sigma fractional uncertainty for laser frequencies measured with this technique is ± 5 parts in 10(7). Accurately determining the frequency of far-infrared laser emissions is critical as they are often used as a reference for other measurements, as in the high-resolution spectroscopic investigations of free radicals using laser magnetic resonance. As part of this investigation, difluoromethane, CH2F2, was used as the far-infrared laser medium. In all, eight far-infrared laser frequencies were measured for the first time with frequencies ranging from 0.359 to 1.273 THz. Three of these laser emissions were discovered during this investigation and are reported with their optimal operating pressure, polarization with respect to the CO2 pump laser, and strength.

  20. Short infrared laser pulses block action potentials in neurons

    NASA Astrophysics Data System (ADS)

    Walsh, Alex J.; Tolstykh, Gleb P.; Martens, Stacey L.; Ibey, Bennett L.; Beier, Hope T.

    2017-02-01

    Short infrared laser pulses have many physiological effects on cells including the ability to stimulate action potentials in neurons. Here we show that short infrared laser pulses can also reversibly block action potentials. Primary rat hippocampal neurons were transfected with the Optopatch2 plasmid, which contains both a blue-light activated channel rhodopsin (CheRiff) and a red-light fluorescent membrane voltage reporter (QuasAr2). This optogenetic platform allows robust stimulation and recording of action potential activity in neurons in a non-contact, low noise manner. For all experiments, QuasAr2 was imaged continuously on a wide-field fluorescent microscope using a Krypton laser (647 nm) as the excitation source and an EMCCD camera operating at 1000 Hz to collect emitted fluorescence. A co-aligned Argon laser (488 nm, 5 ms at 10Hz) provided activation light for CheRiff. A 200 mm fiber delivered infrared light locally to the target neuron. Reversible action potential block in neurons was observed following a short infrared laser pulse (0.26-0.96 J/cm2; 1.37-5.01 ms; 1869 nm), with the block persisting for more than 1 s with exposures greater than 0.69 J/cm2. Action potential block was sustained for 30 s with the short infrared laser pulsed at 1-7 Hz. Full recovery of neuronal activity was observed 5-30s post-infrared exposure. These results indicate that optogenetics provides a robust platform for the study of action potential block and that short infrared laser pulses can be used for non-contact, reversible action potential block.

  1. Study of Nonlinear Propagation of Ultrashort Laser Pulses and Its Application to Harmonic Generation

    NASA Astrophysics Data System (ADS)

    Weerawarne, Darshana L.

    Laser filamentation, which is one of the exotic nonlinear optical phenomena, is self-guidance of high-power laser beams due to the dynamic balance between the optical Kerr effect (self-focusing) and other nonlinear effects such as plasma defocusing. It has many applications including supercontinuum generation (SCG), high-order harmonic generation (HHG), lightning guiding, stand-off sensing, and rain making. The main focus of this work is on studying odd-order harmonic generation (HG) (i.e., 3o, 5o, 7o, etc., where o is the angular frequency) in centrosymmetric media while a high-power, ultrashort harmonic-driving pulse undergoes nonlinear propagation such as laser filamentation. The investigation of highly-controversial nonlinear indices of refraction by measuring low-order HG in air is carried out. Furthermore, time-resolved (i.e., pump-probe) experiments and significant harmonic enhancements are presented and a novel HG mechanism based on higher-order nonlinearities is proposed to explain the experimental results. C/C++ numerical simulations are used to solve the nonlinear Schrodinger equation (NLSE) which supports the experimental findings. Another project which I have performed is selective sintering using lasers. Short-pulse lasers provide a fascinating tool for material processing, especially when the conventional oven-based techniques fail to process flexible materials for smart energy/electronics applications. I present experimental and theoretical studies on laser processing of nanoparticle-coated flexible materials, aiming to fabricate flexible electronic devices.

  2. Bibliography of Soviet Laser Developments, September-October 1987

    DTIC Science & Technology

    1988-10-01

    Lasers , Gas Lasers , Chemical Lasers , Laser Components Nonlinear Optics, Spectroscopy of Laser Materials, Ultrashort Pulse Generation, Laser ...optics; spectroscopy of laser materials; ultrashort pulse generation; crystal growing; theoretical aspects of advanced lasers ; and general laser theory...focusing ....................... 26 6. Acoustic Interaction ................ 26 G. Spectroscopy of Laser Materials ......... 28 H.

  3. Femtosecond timing-jitter between photo-cathode laser and ultra-short electron bunches by means of hybrid compression

    NASA Astrophysics Data System (ADS)

    Pompili, R.; Anania, M. P.; Bellaveglia, M.; Biagioni, A.; Castorina, G.; Chiadroni, E.; Cianchi, A.; Croia, M.; Di Giovenale, D.; Ferrario, M.; Filippi, F.; Gallo, A.; Gatti, G.; Giorgianni, F.; Giribono, A.; Li, W.; Lupi, S.; Mostacci, A.; Petrarca, M.; Piersanti, L.; Di Pirro, G.; Romeo, S.; Scifo, J.; Shpakov, V.; Vaccarezza, C.; Villa, F.

    2016-08-01

    The generation of ultra-short electron bunches with ultra-low timing-jitter relative to the photo-cathode (PC) laser has been experimentally proved for the first time at the SPARC_LAB test-facility (INFN-LNF, Frascati) exploiting a two-stage hybrid compression scheme. The first stage employs RF-based compression (velocity-bunching), which shortens the bunch and imprints an energy chirp on it. The second stage is performed in a non-isochronous dogleg line, where the compression is completed resulting in a final bunch duration below 90 fs (rms). At the same time, the beam arrival timing-jitter with respect to the PC laser has been measured to be lower than 20 fs (rms). The reported results have been validated with numerical simulations.

  4. Start-to-end simulation of single-particle imaging using ultra-short pulses at the European X-ray Free-Electron Laser

    DOE PAGES

    Fortmann-Grote, Carsten; Buzmakov, Alexey; Jurek, Zoltan; ...

    2017-09-01

    Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules. This potential exists because ultra-short intense pulses can produce interpretable diffraction data notwithstanding radiation damage. This paper explores the impact of pulse duration on the interpretability of diffraction data using comprehensive and realistic simulations of an imaging experiment at the European X-ray Free-Electron Laser. In conclusion, it is found that the optimal pulse duration for molecules with a few thousand atoms at 5 keV lies between 3 and 9 fs.

  5. Start-to-end simulation of single-particle imaging using ultra-short pulses at the European X-ray Free-Electron Laser

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fortmann-Grote, Carsten; Buzmakov, Alexey; Jurek, Zoltan

    Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules. This potential exists because ultra-short intense pulses can produce interpretable diffraction data notwithstanding radiation damage. This paper explores the impact of pulse duration on the interpretability of diffraction data using comprehensive and realistic simulations of an imaging experiment at the European X-ray Free-Electron Laser. In conclusion, it is found that the optimal pulse duration for molecules with a few thousand atoms at 5 keV lies between 3 and 9 fs.

  6. Start-to-end simulation of single-particle imaging using ultra-short pulses at the European X-ray Free-Electron Laser

    PubMed Central

    Buzmakov, Alexey; Jurek, Zoltan; Loh, Ne-Te Duane; Samoylova, Liubov; Santra, Robin; Schneidmiller, Evgeny A.; Tschentscher, Thomas; Yakubov, Sergey; Yoon, Chun Hong; Yurkov, Michael V.; Ziaja-Motyka, Beata; Mancuso, Adrian P.

    2017-01-01

    Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules. This potential exists because ultra-short intense pulses can produce interpretable diffraction data notwithstanding radiation damage. This paper explores the impact of pulse duration on the interpretability of diffraction data using comprehensive and realistic simulations of an imaging experiment at the European X-ray Free-Electron Laser. It is found that the optimal pulse duration for molecules with a few thousand atoms at 5 keV lies between 3 and 9 fs. PMID:28989713

  7. Temperature control of the ultra-short laser pulse compression in a one-dimensional photonic band gap structure with nematic liquid crystal as a defect layer

    NASA Astrophysics Data System (ADS)

    Shiri, Ramin; Safari, Ebrahim; Bananej, Alireza

    2018-04-01

    We investigate numerically the controllable chirped pulse compression in a one-dimensional photonic structure containing a nematic liquid crystal defect layer using the temperature dependent refractive index of the liquid crystal. We consider the structure under irradiation by near-infrared ultra-short laser pulses polarized parallel to the liquid crystal director at a normal angle of incidence. It is found that the dispersion behaviour and consequently the compression ability of the system can be changed in a controlled manner due to the variation in the defect temperature. When the temperature increased from 290 to 305 K, the transmitted pulse duration decreased from 75 to 42 fs in the middle of the structure, correspondingly. As a result, a novel low-loss tunable pulse compressor with a really compact size and high compression factor is achieved. The so-called transfer matrix method is utilized for numerical simulations of the band structure and reflection/transmission spectra of the structure under investigation.

  8. Ultrashort x-ray backlighters and applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Umstadter, D., University of Michigan

    Previously, using ultrashort laser pulses focused onto solid targets, we have experimentally studied a controllable ultrafast broadband radiation source in the extreme ultraviolet for time-resolved dynamical studies in ultrafast science [J. Workman, A. Maksimchuk, X. Llu, U. Ellenberger, J. S. Coe, C.-Y. Chien, and D. Umstadter, ``Control of Bright Picosecond X-Ray Emission from Intense Sub- Picosecond Laser-Plasma Interactions,`` Phys. Rev. Lett. 75, 2324 (1995)]. Once armed with a bright ultrafast broadband continuum x-ray source and appropriate detectors, we used the source as a backlighter to study a remotely produced plasma. The application of the source to a problem relevant tomore » high-density matter completes the triad: creating and controlling, efficiently detecting, and applying the source. This work represented the first use of an ultrafast laser- produced x-ray source as a time-resolving probe in an application relevant to atomic, plasma and high-energy-density matter physics. Using the x-ray source as a backlighter, we adopted a pump-probe geometry to investigate the dynamic changes in electronic structure of a thin metallic film as it is perturbed by an ultrashort laser pulse. Because the laser deposits its energy in a skin depth of about 100 {Angstrom} before expansion occurs, up to gigabar pressure shock waves lasting picosecond in duration have been predicted to form in these novel plasmas. This raises the possibility of studying high- energy-density matter relevant to inertial confinement fusion (ICF) and astrophysics in small-scale laboratory experiments. In the past, time-resolved measurements of K-edge shifts in plasmas driven by nanosecond pulses have been used to infer conditions in highly compressed materials. In this study, we used 100-fs laser pulses to impulsively drive shocks into a sample (an untamped 1000 {Angstrom} aluminum film on 2000 {Angstrom} of parylene-n), measuring L-edge shifts.« less

  9. Enhanced hole boring with two-color relativistic laser pulses in the fast ignition scheme

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Changhai; Tian, Ye; Li, Wentao

    A scheme of using two-color laser pulses for hole boring into overdense plasma as well as energy transfer into electron and ion beams has been studied using particle-in-cell simulations. Following an ultra-short ultra-intense hole-boring laser pulse with a short central wavelength in extreme ultra-violet range, the main infrared driving laser pulse can be guided in the hollow channel preformed by the former laser and propagate much deeper into an overdense plasma, as compared to the case using the infrared laser only. In addition to efficiently transferring the main driving laser energy into energetic electrons and ions generation deep inside themore » overdense plasma, the ion beam divergence can be greatly reduced. The results might be beneficial for the fast ignition concept of inertial confinement fusion.« less

  10. A tunable mid-infrared laser source for remote sensing

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.

    1991-01-01

    Many remote sensing needs can be effectively addressed with a tunable laser source in the mid infrared. One potential laser source is an optical parametric oscillator and amplifier system pumped by a near infrared solid state laser. Advantages of such a system and progress made at NASA Langley Research Center to date on such a system are described.

  11. The new methods of treatment for age-related macular degeneration using the ultra-short pulsed laser

    NASA Astrophysics Data System (ADS)

    Iwamoto, Yumiko; Awazu, Kunio; Suzuki, Sachiko; Ohshima, Tetsuro; Sawa, Miki; Sakaguchi, Hirokazu; Tano, Yasuo; Ohji, Masahito

    2007-02-01

    The non-invasive methods of treatments have been studying for the improvement of quality of life (QOL) of patients undergoing treatment. A photodynamic therapy (PDT) is one of the non-invasive treatments. PDT is the methods of treatment using combination of a laser and a photosensitizer. PDT has few risks for patients. Furthermore, PDT enables function preservation of a disease part. PDT has been used for early cancer till now, but in late years it is applied for age-related macular degeneration (AMD). AMD is one of the causes of vision loss in older people. However, PDT for AMD does not produce the best improvement in visual acuity. The skin photosensivity by an absorption characteristic of a photosensitizer is avoided. We examined new PDT using combination of an ultra-short pulsed laser and indocyanine green (ICG).

  12. Infrared laser optogalvanic spectroscopy of molecules

    NASA Technical Reports Server (NTRS)

    Webster, C. R.; Menzies, R. T.

    1983-01-01

    Infrared laser optogalvanic spectra of portions of the NH3 nu3 band at 9.5 microns and the NO2 nu3 band at 6.2 microns have been recorded using CW tunable diode lasers to probe dc electrical discharges in pure NH3 and an NO2/He gas mixture. Two contributions to the optogalvanic signal are identified: one which corresponds to an increase in discharge impedance and is seen only for irradiation of the negative glow region; and a second which corresponds to a decrease in discharge impedance and is seen for irradiation of all other discharge regions and the volume outside the interelectrode region. Mechanisms by which infrared laser irradiation may cause impedance changes in the discharge are proposed.

  13. Au-C allotrope nano-composite films at extreme conditions generated by intense ultra-short laser

    NASA Astrophysics Data System (ADS)

    Khan, Saif A.; Saravanan, K.; Tayyab, M.; Bagchi, S.; Avasthi, D. K.

    2016-07-01

    Structural evolution of gold-carbon allotrope nano-composite films under relativistically intense, ultra-short laser pulse irradiation is studied in this work. Au-C nano-composite films, having 4 and 10 at.% of Au, were deposited by co-sputtering technique on silicon substrates. Au-C60 NC films with 2.5 at.% Au were deposited on 12 μm thick Al foil using co-evaporation technique. These samples were radiated with single pulse from 45 fs, 10 TW Ti:Sapphire Laser at RRCAT at an intensity of 3 × 1018 W cm-2. The morphological and compositional changes were investigated using scanning electron microscopy (SEM) and Rutherford back-scattering spectrometry (RBS) techniques. Laser pulse created three morphologically distinct zones around the point of impact on samples with silicon substrates. The gold content in 600 μm circular region around a point of impact is found to reduce by a factor of five. Annular rings of ∼70 nm in diameter were observed in case of Au-C NC film after irradiation. Laser pulse created a hole of about 400 μm in the sample with Al foil as substrate and wavy structures of 6 μm wavelength are found to be created around this hole. The study shows radial variation in nano-structure formation with varying local intensity of laser pulse.

  14. Laser-induced breakdown spectroscopy using mid-infrared femtosecond pulses

    DOE PAGES

    Hartig, K. C.; Colgan, J.; Kilcrease, D. P.; ...

    2015-07-30

    Here, we report on a laser-induced breakdown spectroscopy (LIBS) experiment driven by mid-infrared (2.05-μm) fs pulses, in which time-resolved emission spectra of copper were studied. Ab-initio modeling is consistent with the results of new fs measurements at 2.05 μm and traditional 800-nm fs-LIBS. Ablation by mid-infrared fs pulses results in a plasma with a lower plasma density and temperature compared to fs-LIBS performed at shorter laser wavelength. LIBS driven by mid-infrared fs pulses results in a signal-to-background ratio ~50% greater and a signal-to-noise ratio ~40% lower than fs-LIBS at near-infrared laser wavelength.

  15. Effects of clinical infrared laser on superficial radial nerve conduction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Greathouse, D.G.; Currier, D.P.; Gilmore, R.L.

    The purposes of this study were to demonstrate the effects of infrared laser radiation on the sensory nerve conduction of a specified peripheral nerve in man and determine temperature changes in the tissue surrounding the treated nerve. Twenty healthy adults were divided into three groups: control (n = 5); experimental (n = 10), infrared laser radiation at 20 sec/cm2; and experimental (n = 5), infrared laser radiation treatment at 120 sec/cm2. Antidromic sensory nerve conduction studies were performed on the superficial radial nerve of each subject's right forearm. The infrared laser radiation was applied at a fixed intensity for fivemore » 1-cm2 segments. Latency, amplitude, and temperature measurements were recorded pretest; posttest; and posttest intervals of 1, 3, 5, 10, and 15 minutes. An analysis of variance with repeated measures was used to examine the data. No significant change was noted in the distal sensory latency or amplitude of the evoked sensory potential in either experimental or control groups as a result of the applications of the infrared laser radiation treatment. This study demonstrates that infrared laser used at clinically applied intensities does not alter conduction of sensory nerves nor does it elevate the subcutaneous temperature.« less

  16. High-throughput machining using a high-average power ultrashort pulse laser and high-speed polygon scanner

    NASA Astrophysics Data System (ADS)

    Schille, Joerg; Schneider, Lutz; Streek, André; Kloetzer, Sascha; Loeschner, Udo

    2016-09-01

    High-throughput ultrashort pulse laser machining is investigated on various industrial grade metals (aluminum, copper, and stainless steel) and Al2O3 ceramic at unprecedented processing speeds. This is achieved by using a high-average power picosecond laser in conjunction with a unique, in-house developed polygon mirror-based biaxial scanning system. Therefore, different concepts of polygon scanners are engineered and tested to find the best architecture for high-speed and precision laser beam scanning. In order to identify the optimum conditions for efficient processing when using high-average laser powers, the depths of cavities made in the samples by varying the processing parameter settings are analyzed and, from the results obtained, the characteristic removal values are specified. For overlapping pulses of optimum fluence, the removal rate is as high as 27.8 mm3/min for aluminum, 21.4 mm3/min for copper, 15.3 mm3/min for stainless steel, and 129.1 mm3/min for Al2O3, when a laser beam of 187 W average laser powers irradiates. On stainless steel, it is demonstrated that the removal rate increases to 23.3 mm3/min when the laser beam is very fast moving. This is thanks to the low pulse overlap as achieved with 800 m/s beam deflection speed; thus, laser beam shielding can be avoided even when irradiating high-repetitive 20-MHz pulses.

  17. Measurement of ultrashort laser pulses using single-crystal films of 4-aminobenzophenone

    NASA Astrophysics Data System (ADS)

    Bhowmik, Achintya K.; Tan, Shida; Ahyi, Ayayi C.; Dharmadhikari, J. A.; Dharmadhikari, A. K.; Mathur, D.

    2007-12-01

    Single-crystal thin-film of an organic second-order nonlinear optical material, 4-aminobenzophenone (ABP), is used to measure the pulsewidth of a Ti-Sapphire laser producing ˜45 fs pulses at 1 kHz repetition rate, by the non-collinear second-harmonic generation (SHG) intensity autocorrelation technique. These films are suitable for measurements over a broad wavelength range, down to 780 nm, due to their wide optical transparency. The single-crystal film with thickness (˜3 μm) less than the coherence length requires no phase-matching for efficient broadband SHG. Pulse walk-off due to group-velocity mismatch (GVM) and temporal broadening of the pulses due to group-velocity dispersion (GVD) are found to be negligible. These effects have been estimated for pulse width down to few-cycle pulses (˜10 fs), and the analyses show that these films can be used to characterize such ultrashort optical pulses.

  18. Process for laser machining and surface treatment

    DOEpatents

    Neil, George R.; Shinn, Michelle D.

    2004-10-26

    An improved method and apparatus increasing the accuracy and reducing the time required to machine materials, surface treat materials, and allow better control of defects such as particulates in pulsed laser deposition. The speed and quality of machining is improved by combining an ultrashort pulsed laser at high average power with a continuous wave laser. The ultrashort pulsed laser provides an initial ultrashort pulse, on the order of several hundred femtoseconds, to stimulate an electron avalanche in the target material. Coincident with the ultrashort pulse or shortly after it, a pulse from a continuous wave laser is applied to the target. The micromachining method and apparatus creates an initial ultrashort laser pulse to ignite the ablation followed by a longer laser pulse to sustain and enlarge on the ablation effect launched in the initial pulse. The pulse pairs are repeated at a high pulse repetition frequency and as often as desired to produce the desired micromachining effect. The micromachining method enables a lower threshold for ablation, provides more deterministic damage, minimizes the heat affected zone, minimizes cracking or melting, and reduces the time involved to create the desired machining effect.

  19. Strong-field physics with mid-infrared lasers

    NASA Astrophysics Data System (ADS)

    Pogorelsky, I. V.

    2002-04-01

    Mid-infrared gas laser technology promises to become a unique tool for research in strong-field relativistic physics. The degree to which physics is relativistic is determined by a ponderomotive potential. At a given intensity, a 10 μm wavelength CO2 laser reaches a 100 times higher ponderomotive potential than the 1 μm wavelength solid state lasers. Thus, we can expect a proportional increase in the throughput of such processes as laser acceleration, x-ray production, etc. These arguments have been confirmed in proof-of-principle Thomson scattering and laser acceleration experiments conducted at BNL and UCLA where the first terawatt-class CO2 lasers are in operation. Further more, proposals for the 100 TW, 100 fs CO2 lasers based on frequency-chirped pulse amplification have been conceived. Such lasers can produce physical effects equivalent to a hypothetical multi-petawatt solid state laser. Ultra-fast mid-infrared lasers will open new routes to the next generation electron and ion accelerators, ultra-bright monochromatic femtosecond x-ray and gamma sources, allow to attempt the study of Hawking-Unruh radiation, and explore relativistic aspects of laser-matter interactions. We review the present status and experiments with terawatt-class CO2 lasers, sub-petawatt projects, and prospective applications in strong-field science. .

  20. Investigation on laser-plasma coupling in intense, ultrashort irradiation of a nanostructured silicon target

    NASA Astrophysics Data System (ADS)

    Cristoforetti, G.; Anzalone, A.; Baffigi, F.; Bussolino, G.; D'Arrigo, G.; Fulgentini, L.; Giulietti, A.; Koester, P.; Labate, L.; Tudisco, S.; Gizzi, L. A.

    2014-09-01

    One of the most interesting research fields in laser-matter interaction studies is the investigation of effects and mechanisms produced by nano- or micro-structured targets, mainly devoted to the enhancing of laser-target or laser-plasma coupling. In intense and ultra-intense laser interaction regimes, the observed enhancement of x-ray plasma emission and/or hot electron conversion efficiency is explained by a variety of mechanisms depending on the dimensions and shape of the structures irradiated. In the present work, the attention is mainly focused on the lowering of the plasma formation threshold which is induced by the larger absorptivity. Flat and nanostructured silicon targets were here irradiated with an ultrashort laser pulse, in the range 1 × 1017-2 × 1018 W µm2 cm-2. The effects of structures on laser-plasma coupling were investigated at different laser pulse polarizations, by utilizing x-ray yield and 3/2ω harmonics emission. While the measured enhancement of x-ray emission is negligible at intensities larger than 1018 W µm2 cm-2, due to the destruction of the structures by the amplified spontaneous emission (ASE) pre-pulse, a dramatic enhancement, strongly dependent on pulse polarization, was observed at intensities lower than ˜3.5 × 1017 W µm2 cm-2. Relying on the three-halves harmonic emission and on the non-isotropic character of the x-ray yield, induced by the two-plasmon decay instability, the results are explained by the significant lowering of the plasma threshold produced by the nanostructures. In this view, the strong x-ray enhancement obtained by s-polarized pulses is produced by the interaction of the laser pulse with the preplasma, resulting from the interaction of the ASE pedestal with the nanostructures.

  1. In situ accurate determination of the zero time delay between two independent ultrashort laser pulses by observing the oscillation of an atomic excited wave packet.

    PubMed

    Zhang, Qun; Hepburn, John W

    2008-08-15

    We propose a novel method that uses the oscillation of an atomic excited wave packet observed through a pump-probe technique to accurately determine the zero time delay between a pair of ultrashort laser pulses. This physically based approach provides an easy fix for the intractable problem of synchronizing two different femtosecond laser pulses in a practical experimental environment, especially where an in situ time zero measurement with high accuracy is required.

  2. Advanced infrared laser modulator development

    NASA Technical Reports Server (NTRS)

    Cheo, P. K.; Wagner, R.; Gilden, M.

    1984-01-01

    A parametric study was conducted to develop an electrooptic waveguide modulator for generating continuous tunable sideband power from an infrared CO2 laser. Parameters included were the waveguide configurations, microstrip dimensions device impedance, and effective dielectric constants. An optimum infrared laser modulator was established and was fabricated. This modulator represents the state-of-the-art integrated optical device, which has a three-dimensional topology to accommodate three lambda/4 step transformers for microwave impedance matching at both the input and output terminals. A flat frequency response of the device over 20 HGz or = 3 dB) was achieved. Maximum single sideband to carrier power greater than 1.2% for 20 W microwave input power at optical carrier wavelength of 10.6 microns was obtained.

  3. Mimicking bug-like surface structures and their fluid transport produced by ultrashort laser pulse irradiation of steel

    NASA Astrophysics Data System (ADS)

    Kirner, S. V.; Hermens, U.; Mimidis, A.; Skoulas, E.; Florian, C.; Hischen, F.; Plamadeala, C.; Baumgartner, W.; Winands, K.; Mescheder, H.; Krüger, J.; Solis, J.; Siegel, J.; Stratakis, E.; Bonse, J.

    2017-12-01

    Ultrashort laser pulses with durations in the fs-to-ps range were used for large area surface processing of steel aimed at mimicking the morphology and extraordinary wetting behaviour of bark bugs (Aradidae) found in nature. The processing was performed by scanning the laser beam over the surface of polished flat sample surfaces. A systematic variation of the laser processing parameters (peak fluence and effective number of pulses per spot diameter) allowed the identification of different regimes associated with characteristic surface morphologies (laser-induced periodic surface structures, i.e., LIPSS, grooves, spikes, etc.). Moreover, different laser processing strategies, varying laser wavelength, pulse duration, angle of incidence, irradiation atmosphere, and repetition rates, allowed to achieve a range of morphologies that resemble specific structures found on bark bugs. For identifying the ideal combination of parameters for mimicking bug-like structures, the surfaces were inspected by scanning electron microscopy. In particular, tilted micrometre-sized spikes are the best match for the structure found on bark bugs. Complementary to the morphology study, the wetting behaviour of the surface structures for water and oil was examined in terms of philic/phobic nature and fluid transport. These results point out a route towards reproducing complex surface structures inspired by nature and their functional response in technologically relevant materials.

  4. Ultrashort polarization-tailored bichromatic fields

    NASA Astrophysics Data System (ADS)

    Kerbstadt, Stefanie; Englert, Lars; Bayer, Tim; Wollenhaupt, Matthias

    2017-06-01

    We present a novel concept for the generation of ultrashort polarization-shaped bichromatic laser fields. The scheme utilizes a 4f polarization pulse shaper based on a liquid crystal spatial light modulator for independent amplitude and phase modulation of femtosecond laser pulses. By choice of either a conventional (p) or a composite (p-s) polarizer in the Fourier plane, the shaper setup enables the generation of parallel linearly and orthogonal linearly polarized bichromatic fields. Additional use of a ? wave plate behind the setup yields co-rotating and counter-rotating circularly polarized bichromatic fields. The scheme allows to independently control the spectral amplitude, phase and polarization profile of the output fields, offering an enormous versatility of bichromatic waveforms.

  5. Beam uniformity analysis of infrared laser illuminators

    NASA Astrophysics Data System (ADS)

    Allik, Toomas H.; Dixon, Roberta E.; Proffitt, R. Patrick; Fung, Susan; Ramboyong, Len; Soyka, Thomas J.

    2015-02-01

    Uniform near-infrared (NIR) and short-wave infrared (SWIR) illuminators are desired in low ambient light detection, recognition, and identification of military applications. Factors that contribute to laser illumination image degradation are high frequency, coherent laser speckle and low frequency nonuniformities created by the laser or external laser cavity optics. Laser speckle analysis and beam uniformity improvements have been independently studied by numerous authors, but analysis to separate these two effects from a single measurement technique has not been published. In this study, profiles of compact, diode laser NIR and SWIR illuminators were measured and evaluated. Digital 12-bit images were recorded with a flat-field calibrated InGaAs camera with measurements at F/1.4 and F/16. Separating beam uniformity components from laser speckle was approximated by filtering the original image. The goal of this paper is to identify and quantify the beam quality variation of illumination prototypes, draw awareness to its impact on range performance modeling, and develop measurement techniques and methodologies for military, industry, and vendors of active sources.

  6. Bibliography of Soviet Laser Developments. Number 43, September-October 1979.

    DTIC Science & Technology

    1980-06-01

    Laser Materials, Ultrashort Pulse Generation, X-ray Lasers , Gamma Lasers , Laser Theory, Laser Biological Effects, Laser Communications, Laser ...chemical lasers ; components; nonlinear optics; spectroscopy of laser materials; ultrashort pulse generation; theoretical aspects of advanced lasers ; and...and A.L. Traynin (0). Study on single crystals of shaped germanium, irradiated by a pulsed CO 2 laser .

  7. X-ray absorption of a warm dense aluminum plasma created by an ultra-short laser pulse

    NASA Astrophysics Data System (ADS)

    Lecherbourg, L.; Renaudin, P.; Bastiani-Ceccotti, S.; Geindre, J.-P.; Blancard, C.; Cossé, P.; Faussurier, G.; Shepherd, R.; Audebert, P.

    2007-05-01

    Point-projection K-shell absorption spectroscopy has been used to measure absorption spectra of transient aluminum plasma created by an ultra-short laser pulse. The 1s-2p and 1s-3p absorption lines of weakly ionized aluminum were measured for an extended range of densities in a low-temperature regime. Independent plasma characterization was obtained using frequency domain interferometry diagnostic (FDI) that allows the interpretation of the absorption spectra in terms of spectral opacities. A detailed opacity code using the density and temperature inferred from the FDI reproduce the measured absorption spectra except in the last stage of the recombination phase.

  8. STRONG FIELD PHYSICS WITH MID INFRARED LASERS.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    POGORELSKY,I.V.

    2001-08-27

    Mid-infrared gas laser technology promises to become a unique tool for research in strong-field relativistic physics. The degree to which physics is relativistic is determined by a ponderomotive potential. At a given intensity, a 10 {micro}m wavelength CO{sub 2} laser reaches a 100 times higher ponderomotive potential than the 1 {micro}m wavelength solid state lasers. Thus, we can expect a proportional increase in the throughput of such processes as laser acceleration, x-ray production, etc. These arguments have been confirmed in proof-of-principle Thomson scattering and laser acceleration experiments conducted at BNL and UCLA where the first terawatt-class CO{sub 2} lasers aremore » in operation. Further more, proposals for the 100 TW, 100 fs CO{sub 2} lasers based on frequency-chirped pulse amplification have been conceived. Such lasers can produce physical effects equivalent to a hypothetical multi-petawatt solid state laser. Ultra-fast mid-infrared lasers will open new routes to the next generation electron and ion accelerators, ultra-bright monochromatic femtosecond x-ray and gamma sources, allow to attempt the study of Hawking-Unruh radiation, and explore relativistic aspects of laser-matter interactions. We review the present status and experiments with terawatt-class CO{sub 2} lasers, sub-petawatt projects, and prospective applications in strong-field science.« less

  9. Efficient dielectric metasurface collimating lenses for mid-infrared quantum cascade lasers.

    PubMed

    Arbabi, Amir; Briggs, Ryan M; Horie, Yu; Bagheri, Mahmood; Faraon, Andrei

    2015-12-28

    Light emitted from single-mode semiconductor lasers generally has large divergence angles, and high numerical aperture lenses are required for beam collimation. Visible and near infrared lasers are collimated using aspheric glass or plastic lenses, yet collimation of mid-infrared quantum cascade lasers typically requires more costly aspheric lenses made of germanium, chalcogenide compounds, or other infrared-transparent materials. Here we report mid-infrared dielectric metasurface flat lenses that efficiently collimate the output beam of single-mode quantum cascade lasers. The metasurface lenses are composed of amorphous silicon posts on a flat sapphire substrate and can be fabricated at low cost using a single step conventional UV binary lithography. Mid-infrared radiation from a 4.8 μm distributed-feedback quantum cascade laser is collimated using a polarization insensitive metasurface lens with 0.86 numerical aperture and 79% transmission efficiency. The collimated beam has a half divergence angle of 0.36° and beam quality factor of M2=1.02.

  10. Efficient dielectric metasurface collimating lenses for mid-infrared quantum cascade lasers

    DOE PAGES

    Arbabi, Amir; Briggs, Ryan M.; Horie, Yu; ...

    2015-01-01

    Light emitted from single-mode semiconductor lasers generally has large divergence angles, and high numerical aperture lenses are required for beam collimation. Visible and near infrared lasers are collimated using aspheric glass or plastic lenses, yet collimation of mid-infrared quantum cascade lasers typically requires more costly aspheric lenses made of germanium, chalcogenide compounds, or other infrared-transparent materials. We report mid-infrared dielectric metasurface flat lenses that efficiently collimate the output beam of single-mode quantum cascade lasers. The metasurface lenses are composed of amorphous silicon posts on a flat sapphire substrate and can be fabricated at low cost using a single step conventionalmore » UV binary lithography. Mid-infrared radiation from a 4.8 μm distributed-feedback quantum cascade laser is collimated using a polarization insensitive metasurface lens with 0.86 numerical aperture and 79% transmission efficiency. The collimated beam has a half divergence angle of 0.36° and beam quality factor of M² =1.02.« less

  11. A review of ultra-short pulse lasers for military remote sensing and rangefinding

    NASA Astrophysics Data System (ADS)

    Lamb, Robert A.

    2009-09-01

    Advances in ultra-short pulse laser technology have resulted in commercially available laser systems capable of generating high peak powers >1GW in tabletop systems. This opens the prospect of generating very wide spectral emissions with a combination of non-linear optical effects in photonic crystal fibres to produce supercontinuua in systems that are readily accessible to military applications. However, military remote sensing rarely requires bandwidths spanning two octaves and it is clear that efficient systems require controlled spectral emission in relevant bands. Furthermore, the limited spectral responsivity of focal plane arrays may impose further restriction on the usable spectrum. A recent innovation which temporally encodes a spectrum using group velocity dispersion allows detection with a photodiode, opening the prospect for high speed hyperspectral sensing and imaging. At the opposite end of the power spectrum, ultra-low power remote sensing using time-correlated single photon counting (SPC) has reduced the laser power requirement and demonstrated remote sensing over 5km during daylight with repetition rates of ~10MHz with ps pulses. Recent research has addressed uncorrelated SPC and waveform transmission to increase data rates for absolute rangefinding whilst avoiding range aliasing. This achievement opens the prospect of combining SPC with high repetition rate temporal encoding of supercontinuua to realise practical hyperspectral remote sensing lidar. The talk will present an overview of these technologies and present a concept which combines them into a single system for high-speed hyperspectral imaging and remote sensing.

  12. Kinetic study of terahertz generation based on the interaction of two-color ultra-short laser pulses with molecular hydrogen gas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soltani Gishini, M. S.; Ganjovi, A., E-mail: Ganjovi@kgut.ac.ir; Saeed, M.

    In this work, using a two dimensional particle in cell-Monte Carlo collision simulation scheme, interaction of two-color ultra-short laser pulses with the molecular hydrogen gas (H{sub 2}) is examined. The operational laser parameters, i.e., its pulse shape, duration, and waist, are changed and, their effects on the density and kinetic energy of generated electrons, THz electric field, intensity, and spectrum are studied. It is seen that the best pulse shape generating the THz signal radiation with the highest intensity is a trapezoidal pulse, and the intensity of generated THz radiation is increased at the higher pulse durations and waists. Formore » all the operational laser parameters, the maximum value of emitted THz signal frequency always remains lower than 5 THz. The intensity of applied laser pulses is taken about 10{sup 14} w/cm{sup 2}, and it is observed that while a small portion of the gaseous media gets ionized, the radiated THz signal is significant.« less

  13. Single-pass, efficient type-I phase-matched frequency doubling of high-power ultrashort-pulse Yb-fiber laser using LiB_3O_5

    NASA Astrophysics Data System (ADS)

    Shukla, Mukesh Kumar; Kumar, Samir; Das, Ritwick

    2016-05-01

    We report 48 % efficient single-pass second harmonic generation of high-power ultrashort-pulse ({≈ }250 fs) Yb-fiber laser by utilizing type-I phase matching in LiB_3O_5 (LBO) crystal. The choice of LBO among other borate crystals for high-power frequency doubling is essentially motivated by large thermal conductivity, low birefringence and weak group velocity dispersion. By optimally focussing the beam in a 4-mm-long LBO crystal, we have generated about 2.3 W of average power at 532 nm using 4.8 W of available pump power at 1064 nm. The ultrashort green pulses were found out to be near-transform limited sech^2 pulses with a pulse width of Δ τ ≈ 150 fs and being delivered at 78 MHz repetition rate. Due to appreciably low spatial walk-off angle for LBO ({≈ }0.4°), we obtain M^2<1.26 for the SH beam which signifies marginal distortion in comparison with the pump beam (M^2<1.15). We also discuss the impact of third-order optical nonlinearity of the LBO crystal on the generated ultrashort SH pulses.

  14. Tunable far infrared laser spectrometers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blake, G.A.; Laughlin, K.B.; Cohen, R.C.

    The state of the art in far infrared (FIR) spectroscopy is reviewed. The development of tunable, coherent FIR radiation sources is discussed. Applications of tunable FIR laser spectrometers for measurement of rotational spectra and dipole moments of molecular ions and free radicals, vibration-rotation-tunneling (VRT) spectra of weakly bound complexes, and vibration-rotation spectra of linear carbon clusters are presented. A detailed description of the Berkeley tunable FIR laser spectrometers is presented in the following article.

  15. Randomized, Controlled Trial of Fractional Carbon Dioxide Laser Resurfacing Followed by Ultrashort Incubation Aminolevulinic Acid Blue Light Photodynamic Therapy for Actinic Keratosis.

    PubMed

    Alexiades, Macrene

    2017-08-01

    Aminolevulinic acid (ALA) photodynamic therapy (PDT) is an established treatment option for actinic keratosis (AK), and recently fractional carbon dioxide (CO2) laser was shown to improve outcomes; but studies of short incubation photosensitizer are lacking. Assess the efficacy of short incubation ALA followed by blue light PDT with and without previous fractional CO2 treatment for the treatment of AK. Randomized, paired split-design, controlled trial of fractional CO2 followed by ultrashort 15-minute versus 30-minute incubation ALA and blue light PDT for the treatment of AK on the face. The complete clearance rates (CRs) at 8 weeks after ALA PDT with and without FxCO2 at 30- and 15-minute ALA incubation times were 89.78% (+FxCO2) versus 71.20% CR (-FxCO2) at 30', and 86.38% (+FxCO2) versus 69.23% (-FxCO2) at 15' ALA incubation. All lesion improvements were statistically significant. This randomized, comparative paired group controlled clinical study demonstrates that ultrashort 15- and 30-minute incubation ALA PDTs are of limited efficacy for the treatment of AK. Pretreatment with fractional ablative resurfacing yields statistically significant greater AK clearance with ALA-PDT at ultrashort ALA incubations followed by blue light.

  16. Mid-infrared supercontinuum covering the 1.4-13.3 μm molecular fingerprint region using ultra-high NA chalcogenide step-index fibre

    NASA Astrophysics Data System (ADS)

    Petersen, Christian Rosenberg; Møller, Uffe; Kubat, Irnis; Zhou, Binbin; Dupont, Sune; Ramsay, Jacob; Benson, Trevor; Sujecki, Slawomir; Abdel-Moneim, Nabil; Tang, Zhuoqi; Furniss, David; Seddon, Angela; Bang, Ole

    2014-11-01

    The mid-infrared spectral region is of great technical and scientific interest because most molecules display fundamental vibrational absorptions in this region, leaving distinctive spectral fingerprints. To date, the limitations of mid-infrared light sources such as thermal emitters, low-power laser diodes, quantum cascade lasers and synchrotron radiation have precluded mid-infrared applications where the spatial coherence, broad bandwidth, high brightness and portability of a supercontinuum laser are all required. Here, we demonstrate experimentally that launching intense ultra-short pulses with a central wavelength of either 4.5 μm or 6.3 μm into short pieces of ultra-high numerical-aperture step-index chalcogenide glass optical fibre generates a mid-infrared supercontinuum spanning 1.5 μm to 11.7 μm and 1.4 μm to 13.3 μm, respectively. This is the first experimental demonstration to truly reveal the potential of fibres to emit across the mid-infrared molecular ‘fingerprint region’, which is of key importance for applications such as early cancer diagnostics, gas sensing and food quality control.

  17. Polarization-maintaining, high-energy, wavelength-tunable, Er-doped ultrashort pulse fiber laser using carbon-nanotube polyimide film.

    PubMed

    Senoo, Y; Nishizawa, N; Sakakibara, Y; Sumimura, K; Itoga, E; Kataura, H; Itoh, K

    2009-10-26

    A high-energy, wavelength-tunable, all-polarization-maintaining Er-doped ultrashort fiber laser was demonstrated using a polyimide film dispersed with single-wall carbon nanotubes. A variable output coupler and wavelength filter were used in the cavity configuration, and high-power operation was demonstrated. The maximum average power was 12.6 mW and pulse energy was 585 pJ for stable single-pulse operation with an output coupling ratio as high as 98.3%. Wide wavelength-tunable operation at 1532-1562 nm was also demonstrated by controlling the wavelength filter. The RF amplitude noise characteristics were examined in terms of their dependence on output coupling ratio and oscillation wavelength.

  18. Room temperature optical anisotropy of a LaMnO 3 thin-film induced by ultra-short pulse laser

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Munkhbaatar, Purevdorj; Marton, Zsolt; Tsermaa, Bataarchuluun

    Ultra-short laser pulse induced optical anisotropy of LaMnO 3 thin films grown on SrTiO 3 substrates were observed by irradiation with a femto-second laser pulse with the fluence of less than 0.1 mJ/cm 2 at room temperature. The transmittance and reflectance showed different intensities for different polarization states of the probe pulse after pump pulse irradiation. The theoretical optical transmittance and re ectance that assumed an orbital ordering of the 3d eg electrons in Mn 3+ ions resulted in an anisotropic time dependent changes similar to those obtained from the experimental results, suggesting that the photo-induced optical anisotropy of LaMnOmore » 3 is a result of photo-induced symmetry breaking of the orbital ordering for an optically excited state.« less

  19. Ultra-short pulse generation in the hybridly mode-locked erbium-doped all-fiber ring laser with a distributed polarizer

    NASA Astrophysics Data System (ADS)

    Krylov, Alexander A.; Sazonkin, Stanislav G.; Lazarev, Vladimir A.; Dvoretskiy, Dmitriy A.; Leonov, Stanislav O.; Pnev, Alexey B.; Karasik, Valeriy E.; Grebenyukov, Vyacheslav V.; Pozharov, Anatoly S.; Obraztsova, Elena D.; Dianov, Evgeny M.

    2015-06-01

    We report for the first time to the best of our knowledge on the ultra-short pulse (USP) generation in the dispersion-managed erbium-doped all-fiber ring laser hybridly mode-locked with boron nitride-doped single-walled carbon nanotubes in the co-action with a nonlinear polarization evolution in the ring cavity with a distributed polarizer. Stable 92.6 fs dechirped pulses were obtained via precise polarization state adjustment at a central wavelength of 1560 nm with 11.2 mW average output power, corresponding to the 2.9 kW maximum peak power. We have also observed the laser switching from a USP generation regime to a chirped pulse one with a corresponding pulse-width of 7.1 ps at the same intracavity dispersion.

  20. Interface modification based ultrashort laser microwelding between SiC and fused silica.

    PubMed

    Zhang, Guodong; Bai, Jing; Zhao, Wei; Zhou, Kaiming; Cheng, Guanghua

    2017-02-06

    It is a big challenge to weld two materials with large differences in coefficients of thermal expansion and melting points. Here we report that the welding between fused silica (softening point, 1720°C) and SiC wafer (melting point, 3100°C) is achieved with a near infrared femtosecond laser at 800 nm. Elements are observed to have a spatial distribution gradient within the cross section of welding line, revealing that mixing and inter-diffusion of substances have occurred during laser irradiation. This is attributed to the femtosecond laser induced local phase transition and volume expansion. Through optimizing the welding parameters, pulse energy and interval of the welding lines, a shear joining strength as high as 15.1 MPa is achieved. In addition, the influence mechanism of the laser ablation on welding quality of the sample without pre-optical contact is carefully studied by measuring the laser induced interface modification.

  1. Control of intracellular ionic concentrations by mid-infrared laser irradiation

    NASA Astrophysics Data System (ADS)

    Takebe, G.; Yamauchi, T.; Shimizu, Y.; Dougakiuchi, T.

    2018-02-01

    We successfully induced intracellular ion concentration changes in live culture cells using mid-infrared laser irradiation. The laser used for irradiation was a quantum cascade laser with a wavelength of 6.1 micrometers. We tuned the power of the laser to be between 30 to 60 mW at the sample. Cell lines, namely HeLa and Chinese hamster ovary cell lines, were used. They were cultured on specially fabricated silicon-bottom dishes. Live cells were stained using ion-sensitive dyes such as Calcium Green-1. The mid-infrared light was incident on the cell samples from the bottom of the dish through the silicon plate, and fluorescence imaging of the ion concentrations was performed using an upright fluorescence microscope placed on top of the sample stage. The mid-infrared lasers were operated in the continuous wave mode and light irradiations onto the cells were temporally controlled using a mechanical shutter in a periodical on-and-off pattern in the second timescale. The cells showed oscillations in their ionic concentration, which was synchronized with the periodical mid-infrared irradiation, and the threshold power needed for evoking the ion concentration change was dependent on the cell types and ion species. These results demonstrated that mid-infrared light directly changed the ionic response within cells and had the ability to change cell functions.

  2. Triangular laser-induced submicron textures for functionalising stainless steel surfaces

    NASA Astrophysics Data System (ADS)

    Romano, Jean-Michel; Garcia-Giron, Antonio; Penchev, Pavel; Dimov, Stefan

    2018-05-01

    Processing technologies that engineer surfaces with sub-micron topographies are of a growing interest to a range of optical, hydrophobic and microbiological applications. One of the promising technologies for creating such topographies employs ultra-short laser pulses to produce laser-induced periodic surface structures (LIPSS) that often result in non-regular, quasi-periodic nanoripples and nanopillars. In this research near infrared ultra-short pulses of 310 fs with a circular polarisation was used to texture ferritic stainless steel workpieces. A single-step process was designed to generate low spatial frequency LIPSS (LSFL) over relatively large areas. Apart from highly regular and homogeneous parallel lines with approximately 900 nm periodicity, extraordinarily uniform triangular-LSFL in hexagonal arrangements was created. The generation of such LSFL was found to be highly repeatable but very sensitive to the used laser processing settings. Therefore, the sensitivity of triangular-LSFL formation to the used laser processing settings, i.e. pulse to pulse distance, pulse fluence and focal plane offsets, were investigated in regard to the resulting morphologies and functional properties, i.e. structural colors and super-hydrophobicity. Finally, the capability of this technology for producing uniform triangular-shaped LSFL on relatively large surface areas of stainless steel plates was studied.

  3. Theoretical analysis and simulations of strong terahertz radiation from the interaction of ultrashort laser pulses with gases

    NASA Astrophysics Data System (ADS)

    Chen, Min; Pukhov, Alexander; Peng, Xiao-Yu; Willi, Oswald

    2008-10-01

    Terahertz (THz) radiation from the interaction of ultrashort laser pulses with gases is studied both by theoretical analysis and particle-in-cell (PIC) simulations. A one-dimensional THz generation model based on the transient ionization electric current mechanism is given, which explains the results of one-dimensional PIC simulations. At the same time the relation between the final THz field and the initial transient ionization current is shown. One- and two-dimensional simulations show that for the THz generation the contribution of the electric current due to ionization is much larger than the one driven by the usual ponderomotive force. Ionization current generated by different laser pulses and gases is also studied numerically. Based on the numerical results we explain the scaling laws for THz emission observed in the recent experiments performed by Xie [Phys. Rev. Lett. 96, 075005 (2006)]. We also study the effective parameter region for the carrier envelop phase measurement by the use of THz generation.

  4. Theoretical analysis and simulations of strong terahertz radiation from the interaction of ultrashort laser pulses with gases.

    PubMed

    Chen, Min; Pukhov, Alexander; Peng, Xiao-Yu; Willi, Oswald

    2008-10-01

    Terahertz (THz) radiation from the interaction of ultrashort laser pulses with gases is studied both by theoretical analysis and particle-in-cell (PIC) simulations. A one-dimensional THz generation model based on the transient ionization electric current mechanism is given, which explains the results of one-dimensional PIC simulations. At the same time the relation between the final THz field and the initial transient ionization current is shown. One- and two-dimensional simulations show that for the THz generation the contribution of the electric current due to ionization is much larger than the one driven by the usual ponderomotive force. Ionization current generated by different laser pulses and gases is also studied numerically. Based on the numerical results we explain the scaling laws for THz emission observed in the recent experiments performed by Xie et al. [Phys. Rev. Lett. 96, 075005 (2006)]. We also study the effective parameter region for the carrier envelop phase measurement by the use of THz generation.

  5. Ultraviolet-infrared laser-induced domain inversion in MgO-doped congruent LiNbO3 and near stoichiometric LiTaO3 crystals

    NASA Astrophysics Data System (ADS)

    Zhi, Ya'nan; Qu, Weijuan; Liu, De'an; Sun, Jianfeng; Yan, Aimin; Liu, Liren

    2008-08-01

    Laser-induced domain inversion is a promising technique for domain engineering in LiNbO3 and LiTaO3. The ultraviolet-infrared laser induced domain inversions in MgO-doped congruent LiNbO3 and near stoichiometric LiTaO3 crystals are investigated for the first time here. Within the wavelength range from 351 to 799 nm, the different reductions of nucleation field induced by the focused continuous laser irradiation are systematically investigated in the MgO-doped congruent LiNbO3 crystals. The investigation of ultrashort-pulse laser-induced domain inversion in MgO-doped congruent LiNbO3 is performed with 800 nm wavelength irradiation. The focused continuous ultraviolet laser-induced ferroelectric domain inversion in the near stoichiometric LiTaO3 is also investigated. The different physical explanations, based on space charge field and defect formation, are presented for the laser-induced domain inversion, and the solid experimental proofs are also presented. The results provide the solid experimental proofs and feasible schemes for the further investigation of laser-induced domain engineering in MgO-doped LiNbO3 and near stoichiometric LiTaO3 crystals. The important characteristics of domain inversion, including domain wall and internal field, in LiNbO3 crystals are also investigated by the digital holographic interferometry with an improved reconstruction method, and some creative experimental results and conclusions are achieved.

  6. Application of Advanced Laser Diagnostics to High-Impact Technologies: Science and Applications of Ultrafast, Ultraintense Lasers

    DTIC Science & Technology

    2013-11-01

    ultrashort - pulse lasers because of the very large photon density. As the intensity increases, the electric field of the light can modify the Coulomb ...absorption studies of argon clusters in intense laser pulses ,” Physics of Plasmas 16(4), 043301-1 – 043301-5. Lu, W., Nicoul, M., Shymanovich, U... intensity of ultrashort - pulse lasers , possess unique and advantageous capabilities for use in a wide variety of applications and are

  7. Low intensity infrared laser induces filamentation in Escherichia coli cells

    NASA Astrophysics Data System (ADS)

    Fonseca, A. S.; Presta, G. A.; Geller, M.; Paoli, F.

    2011-10-01

    Low intensity continuous wave and pulsed emission modes laser is used in treating many diseases and the resulting biostimulative effect on tissues has been described, yet the photobiological basis is not well understood. The aim of this wok was to evaluate, using bacterial filamentation assay, effects of laser on Escherichia coli cultures in exponential and stationary growth phase. E. coli cultures, proficient and deficient on DNA repair, in exponential and stationary growth phase, were exposed to low intensity infrared laser, aliquots were spread onto microscopic slides, stained by Gram method, visualized by optical microscopy, photographed and percentage of bacterial filamentation were determined. Low intensity infrared laser with therapeutic fluencies and different emission modes can induce bacterial filamentation in cultures of E. coli wild type, fpg/ mutM, endonuclease III and exonuclease III mutants in exponential and stationary growth phase. This study showed induction of bacterial, filamentation in E. coli cultures expose to low intensity infrared laser and attention to laser therapy protocols, which should take into account fluencies, wavelengths, tissue conditions, and genetic characteristics of cells before beginning treatment.

  8. Nonlinear scattering of ultrashort laser pulses on two-level system

    NASA Astrophysics Data System (ADS)

    Astapenko, Valery A.; Sakhno, Sergey V.

    2015-05-01

    The presentation is devoted to the theoretical investigation of nonlinear scattering of ultrashort electromagnetic pulses (USP) on two-level quantum system. We consider the scattering of several types of USP, namely, so called corrected Gaussian pulse (CGP) and cosine wavelet pulse. Such pulses have no constant component in their spectrum in contrast with traditional Gaussian pulse. It should be noted that the presence of constant component in the limit of ultrashort pulse durations leads to unphysical results. The main purpose of the present work is the investigation of the change of pulse temporal shape after scattering as a function of initial phase at different distances from the target. Numerical calculations are based on the solution of Bloch equations and expression for scattering field strength via dipole moment of two-level system exposed by the action of incident USP. In our calculation we also account for the influence of refracting index of the air on electric field strength in the pulse after scattering.

  9. Cryogenic Tm: YAG Laser in the Near Infrared

    DTIC Science & Technology

    2015-05-29

    Applications Group. The focus of his work at Lincoln Laboratory has been solid-state lasers including microchip lasers , external-cavity diode lasers ...REPLACE THIS LINE WITH YOUR PAPER IDENTIFICATION NUMBER (DOUBLE-CLICK HERE TO EDIT) < Cryogenic Tm:YAG Laser in the Near Infrared* Tso Yee Fan...Senior Member, IEEE, Juan R. Ochoa, and Patricia A. Reed Abstract- Thulium laser operation on the 3H4 - 3H6 transition at 823 nm has been demonstrated

  10. Transient Infrared Measurement of Laser Absorption Properties of Porous Materials

    NASA Astrophysics Data System (ADS)

    Marynowicz, Andrzej

    2016-06-01

    The infrared thermography measurements of porous building materials have become more frequent in recent years. Many accompanying techniques for the thermal field generation have been developed, including one based on laser radiation. This work presents a simple optimization technique for estimation of the laser beam absorption for selected porous building materials, namely clinker brick and cement mortar. The transient temperature measurements were performed with the use of infrared camera during laser-induced heating-up of the samples' surfaces. As the results, the absorbed fractions of the incident laser beam together with its shape parameter are reported.

  11. Laser- and Particle-Beam Chemical Processes on Surfaces. Volume 129

    DTIC Science & Technology

    1989-12-26

    explosive decomposition of organometallic compounds with single pulse laser irradiation . This new... ultrashort , meaning ultra high intensity , excimer laser pulses , two-photon absorption becomes important and limits the penetration depth of the laser ...requires a higher photon load before suffering damage to its chemical structure. With extremely high light intensities , ultrashort excimer laser pulses

  12. Satellite and lunar laser ranging in infrared

    NASA Astrophysics Data System (ADS)

    Courde, Clement; Torre, Jean-Marie; Samain, Etienne; Martinot-Lagarde, Gregoire; Aimar, Mourad; Albanese, Dominique; Maurice, Nicolas; Mariey, Hervé; Viot, Hervé; Exertier, Pierre; Fienga, Agnes; Viswanathan, Vishnu

    2017-05-01

    We report on the implementation of a new infrared detection at the Grasse lunar laser ranging station and describe how infrared telemetry improves the situation. We present our first results on the lunar reflectors and show that infrared detection permits us to densify the observations and allows measurements during the new and the full moon periods. We also present the benefit obtained on the ranging of Global Navigation Satellite System (GNSS) satellites and on RadioAstron which have a very elliptic orbit.

  13. Development of selective laser treatment techniques using mid-infrared tunable nanosecond pulsed laser.

    PubMed

    Ishii, Katsunori; Saiki, Masayuki; Hazama, Hisanao; Awazu, Kunio

    2010-01-01

    Mid-infrared (MIR) laser with a specific wavelength can excite the corresponding biomolecular site to regulate chemical, thermal and mechanical interactions to biological molecules and tissues. In laser surgery and medicine, tunable MIR laser irradiation can realize the selective and less-invasive treatments and the special diagnosis by vibrational spectroscopic information. This paper showed a novel selective therapeutic technique for a laser angioplasty of atherosclerotic plaques and a laser dental surgery of a carious dentin using a MIR tunable nanosecond pulsed laser.

  14. Cutting and skin-ablative properties of pulsed mid-infrared laser surgery.

    PubMed

    Kaufmann, R; Hartmann, A; Hibst, R

    1994-02-01

    Pulsed mid-infrared lasers allow a precise removal of soft tissues with only minimal thermal damage. To study the potential dermatosurgical usefulness of currently available systems at different wavelengths (2010-nm Thulium:YAG laser, 2100-nm Holmium:YAG laser, 2790-nm Erbium:YSGG laser, and 2940-nm Erbium:YAG laser) in vivo on pig skin. Immediate effects and wound healing of superficial laser-abrasions and incisions were compared with those of identical control lesions produced by dermabrasion, scalpel incisions, or laser surgery performed by a 1060-nm Nd:YAG and a 1060-nm CO2 laser (continuous and superpulsed mode). Best efficiency and least thermal injury was found for the pulsed Erbium:YAG laser, leading to ablative and incisional lesions comparable to those obtained by dermabrasion or superficial scalpel incisions, respectively. In contrast to other mid-infrared lasers tested, the 2940-nm Erbium:YAG laser thus provides a potential instrument for future applications in skin surgery, especially when aiming at a careful ablative removal of delicate superficial lesions with maximum sparing of adjacent tissue structures. However, in the purely incisional application mode pulsed mid-infrared lasers, though of potential usefulness in microsurgical indications (eg, surgery of the cornea), do not offer a suggestive alternative to simple scalpel surgery of the skin.

  15. Airborne laser systems for atmospheric sounding in the near infrared

    NASA Astrophysics Data System (ADS)

    Sabatini, Roberto; Richardson, Mark A.; Jia, Huamin; Zammit-Mangion, David

    2012-06-01

    This paper presents new techniques for atmospheric sounding using Near Infrared (NIR) laser sources, direct detection electro-optics and passive infrared imaging systems. These techniques allow a direct determination of atmospheric extinction and, through the adoption of suitable inversion algorithms, the indirect measurement of some important natural and man-made atmospheric constituents, including Carbon Dioxide (CO2). The proposed techniques are suitable for remote sensing missions performed by using aircraft, satellites, Unmanned Aerial Vehicles (UAV), parachute/gliding vehicles, Roving Surface Vehicles (RSV), or Permanent Surface Installations (PSI). The various techniques proposed offer relative advantages in different scenarios. All are based on measurements of the laser energy/power incident on target surfaces of known geometric and reflective characteristics, by means of infrared detectors and/or infrared cameras calibrated for radiance. Experimental results are presented relative to ground and flight trials performed with laser systems operating in the near infrared (NIR) at λ = 1064 nm and λ = 1550 nm. This includes ground tests performed with 10 Hz and 20 KHz PRF NIR laser systems in a variety of atmospheric conditions, and flight trials performed with a 10 Hz airborne NIR laser system installed on a TORNADO aircraft, flying up to altitudes of 22,000 ft above ground level. Future activities are planned to validate the atmospheric retrieval algorithms developed for CO2 column density measurements, with emphasis on aircraft related emissions at airports and other high air-traffic density environments.

  16. Modeling ultrashort electromagnetic pulses with a generalized Kadomtsev-Petviashvili equation

    NASA Astrophysics Data System (ADS)

    Hofstrand, A.; Moloney, J. V.

    2018-03-01

    In this paper we derive a properly scaled model for the nonlinear propagation of intense, ultrashort, mid-infrared electromagnetic pulses (10-100 femtoseconds) through an arbitrary dispersive medium. The derivation results in a generalized Kadomtsev-Petviashvili (gKP) equation. In contrast to envelope-based models such as the Nonlinear Schrödinger (NLS) equation, the gKP equation describes the dynamics of the field's actual carrier wave. It is important to resolve these dynamics when modeling ultrashort pulses. We proceed by giving an original proof of sufficient conditions on the initial pulse for a singularity to form in the field after a finite propagation distance. The model is then numerically simulated in 2D using a spectral-solver with initial data and physical parameters highlighting our theoretical results.

  17. Mid-Infrared Laser Orbital Septal Tightening

    PubMed Central

    Chu, Eugene A.; Li, Michael; Lazarow, Frances B.; Wong, Brian J. F.

    2014-01-01

    IMPORTANCE Blepharoplasty is one of the most commonly performed facial aesthetic surgeries. While myriad techniques exist to improve the appearance of the lower eyelids, there is no clear consensus on the optimal management of the orbital septum. OBJECTIVES To evaluate the safety and feasibility of the use of the holmium:yttrium aluminum garnet (Ho:YAG) laser for orbital septal tightening, and to determine whether modest use of this laser would provide some degree of clinical efficacy. DESIGN, SETTING, AND PARTICIPANTS Direct laser irradiation of ex vivo bovine tissue was used to determine appropriate laser dosimetry using infrared thermal imaging and optical coherence tomography before conducting a pilot clinical study in 5 patients. Laser irradiation of the lower eyelid orbital septum was performed through a transconjunctival approach. Standardized preoperative and postoperative photographs were taken for each patient and evaluated by 6 unbiased aesthetic surgeons. EXPOSURE Use of the Ho:YAG laser for orbital septal tightening. MAIN OUTCOME AND MEASURE To determine appropriate laser dosimetry, infrared thermal imaging and optical coherence tomography were used to monitor temperature and tissue shape changes of ex vivo bovine tissue that was subjected to direct laser irradiation. For the clinical study, preoperative and postoperative photographs were evaluated by 6 surgeons on a 10-point Likert scale. RESULTS Optical coherence tomography demonstrated that laser irradiation of bovine tissue to a temperature range of 60°C to 80°C resulted in an increase in thickness of up to 2-fold. There were no complications or adverse cosmetic outcomes in the patient study. Patient satisfaction with the results of surgery averaged 7 on a 10-point Likert scale. For 3 patients, 3 (50%) of the evaluators believed there was a mild improvement in appearance of the lower eyelids after surgery. The remaining patients were thought to have no significant changes. CONCLUSIONS AND

  18. Infrared-laser-based fundus angiography

    NASA Astrophysics Data System (ADS)

    Klingbeil, Ulrich; Canter, Joseph M.; Lesiecki, Michael L.; Reichel, Elias

    1994-06-01

    Infrared fundus angiography, using the fluorescent dye indocyanine green (ICG), has shown great potential in delineating choroidal neovascularization (CNV) otherwise not detectable. A digital retinal imaging system containing a diode laser for illumination has been developed and optimized to perform high sensitivity ICG angiography. The system requires less power and generates less pseudo-fluorescence background than nonlaser devices. During clinical evaluation at three retinal centers more than 200 patients, the majority of which had age-related macular degeneration, were analyzed. Laser based ICG angiography was successful in outlining many of the ill-defined or obscure CNV as defined by fluorescein angiography. The procedure was not as successful with classic CNV. ICG angiograms were used to prepare and guide laser treatment.

  19. Study of cylindrical optical micro-structure technology used in infrared laser protection

    NASA Astrophysics Data System (ADS)

    Sun, Yanjun; Liu, Shunrui; Wang, Zhining; Zhao, Yixuan; Wu, Boqi; Leng, Yanbing; Wang, Li

    2016-10-01

    The paper aimed at the problem that strong absorption in visible wavelengths and equipment or operator injury caused by specular reflection exist in infrared laser protection technology to propose an infrared laser non-specular reflection optical micro-structure formed from optical window surface. It has the function of little effect on visible light transmission and large-angle scattering to 1064nm infrared laser in order to enable laser protection. The paper uses light track method to design double-side micro-cylindrical lens arrays with dislocation construction. Array period T and curvature radius of lens units R should meet the condition:0infrared laser reflection is about 75%, divergence angle is greater than 30%,which greatly reduces the single-directivity reflection echo energy of laser to achieve the purpose of laser protection.

  20. Phase-locked, erbium-fiber-laser-based frequency comb in the near infrared.

    PubMed

    Washburn, Brian R; Diddams, Scott A; Newbury, Nathan R; Nicholson, Jeffrey W; Yan, Man F; Jørgensen, Carsten G

    2004-02-01

    A phase-locked frequency comb in the near infrared is demonstrated with a mode-locked, erbium-doped, fiber laser whose output is amplified and spectrally broadened in dispersion-flattened, highly nonlinear optical fiber to span from 1100 to >2200 nm. The supercontinuum output comprises a frequency comb with a spacing set by the laser repetition rate and an offset by the carrier-envelope offset frequency, which is detected with the standard f-to-2f heterodyne technique. The comb spacing and offset frequency are phase locked to a stable rf signal with a fiber stretcher in the laser cavity and by control of the pump laser power, respectively. This infrared comb permits frequency metrology experiments in the near infrared in a compact, fiber-laser-based system.

  1. Improving executive function using transcranial infrared laser stimulation

    PubMed Central

    Blanco, Nathaniel J.; Maddox, W. Todd; Gonzalez-Lima, F.

    2015-01-01

    Transcranial infrared laser stimulation is a new non-invasive form of low-level light therapy that may have a wide range of neuropsychological applications. It entails using low-power and high-energy density infrared light from lasers to increase metabolic energy. Preclinical work showed that this intervention can increase cortical metabolic energy, thereby improving frontal cortex-based memory function in rats. Barrett & Gonzalez-Lima (2013) discovered that transcranial laser stimulation can enhance sustained attention and short-term memory in humans. We extend this line of work to executive function. Specifically, we ask whether transcranial laser stimulation enhances performance in the Wisconsin Card Sorting Task (WCST) that is considered the gold-standard of executive function and is compromised in normal aging and a number of neuropsychological disorders. We used a laser of a specific wavelength (1064 nm) that photostimulates cytochrome oxidase—the enzyme catalyzing oxygen consumption for metabolic energy production. Increased cytochrome oxidase activity is considered the primary mechanism of action of this intervention. Participants who received laser treatment made fewer errors and showed improved set-shifting ability relative to placebo controls. These results suggest that transcranial laser stimulation improves executive function and may have exciting potential for treating or preventing deficits resulting from neuropsychological disorders or normal aging. PMID:26017772

  2. An infrared search for extraterrestrial laser signals

    NASA Technical Reports Server (NTRS)

    Betz, A.

    1986-01-01

    The focus of project SETI is on microwave frequencies, where receivers fundamentally have the best sensitivity for the detection of narrow band signals. Such receivers, when coupled to existing radio telescopes, form an optimum system for broad area searches over the sky. Detection of narrow band infrared signals is best done with a laser heterodyne reciever similar in function to a microwave spectral line receiver. A receiver was built for astrophysical observations at 30 THz (10 microns) and the spectrometer is being adapted for SETI work. The receiver uses a small CO2 laser as the local oscillator, a HgCdTe diode as the photomixer, and a multichannel intermediate frequency (IF) filterbank. An advanced multichannel IF processor is now being built to detect infrared line radiation in 1000 spectral channels each 1 MHz wide. When completed this processor will be used with a ground based telescope next year for a survey of several hundred selected stars for narrow band CO2 laser signals at 30 THz.

  3. Determination of ultra-short laser induced damage threshold of KH{sub 2}PO{sub 4} crystal: Numerical calculation and experimental verification

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cheng, Jian; Department of Physics, The Ohio State University, 191 W. Woodruff Ave, Columbus, OH 43210; Chen, Mingjun, E-mail: chenmj@hit.edu.cn, E-mail: chowdhury.24@osu.edu

    Rapid growth and ultra-precision machining of large-size KDP (KH{sub 2}PO{sub 4}) crystals with high laser damage resistance are tough challenges in the development of large laser systems. It is of high interest and practical significance to have theoretical models for scientists and manufacturers to determine the laser-induced damage threshold (LIDT) of actually prepared KDP optics. Here, we numerically and experimentally investigate the laser-induced damage on KDP crystals in ultra-short pulse laser regime. On basis of the rate equation for free electron generation, a model dedicated to predicting the LIDT is developed by considering the synergistic effect of photoionization, impact ionizationmore » and decay of electrons. Laser damage tests are performed to measure the single-pulse LIDT with several testing protocols. The testing results combined with previously reported experimental data agree well with those calculated by the model. By taking the light intensification into consideration, the model is successfully applied to quantitatively evaluate the effect of surface flaws inevitably introduced in the preparation processes on the laser damage resistance of KDP crystals. This work can not only contribute to further understanding of the laser damage mechanisms of optical materials, but also provide available models for evaluating the laser damage resistance of exquisitely prepared optical components used in high power laser systems.« less

  4. Infrared laser damage thresholds in corneal tissue phantoms using femtosecond laser pulses

    NASA Astrophysics Data System (ADS)

    Boretsky, Adam R.; Clary, Joseph E.; Noojin, Gary D.; Rockwell, Benjamin A.

    2018-02-01

    Ultrafast lasers have become a fixture in many biomedical, industrial, telecommunications, and defense applications in recent years. These sources are capable of generating extremely high peak power that can cause laser-induced tissue breakdown through the formation of a plasma upon exposure. Despite the increasing prevalence of such lasers, current safety standards (ANSI Z136.1-2014) do not include maximum permissible exposure (MPE) values for the cornea with pulse durations less than one nanosecond. This study was designed to measure damage thresholds in corneal tissue phantoms in the near-infrared and mid-infrared to identify the wavelength dependence of laser damage thresholds from 1200-2500 nm. A high-energy regenerative amplifier and optical parametric amplifier outputting 100 femtosecond pulses with pulse energies up to 2 mJ were used to perform exposures and determine damage thresholds in transparent collagen gel tissue phantoms. Three-dimensional imaging, primarily optical coherence tomography, was used to evaluate tissue phantoms following exposure to determine ablation characteristics at the surface and within the bulk material. The determination of laser damage thresholds in the near-IR and mid-IR for ultrafast lasers will help to guide safety standards and establish the appropriate MPE levels for exposure sensitive ocular tissue such as the cornea. These data will help promote the safe use of ultrafast lasers for a wide range of applications.

  5. All-fiber mode-locked erbium-doped ring laser based on a highly-nonlinear resonator with a low-noise ultrashort pulse generation

    NASA Astrophysics Data System (ADS)

    Kudelin, Igor S.; Dvoretskiy, Dmitriy A.; Sazonkin, Stanislav G.; Orekhov, Ilya O.; Pnev, Alexey B.; Karasik, Valeriy E.; Denisov, Lev K.

    2018-04-01

    Ultrashort pulse (USP) fiber lasers have found applications in such various fields as frequency metrology and spectroscopy, telecommunication systems, etc. For the last decade, mode-locking (ML) fiber lasers have been under carefully investigations for scientific, medical and industrial applications. Also, USP fiber sources can be treated as an ideal platform to expand future applications due to the complex ML nonlinear dynamics with a presence of high value of group velocity dispersion (GVD) and the third order dispersion in the resonator. For more reliable and robust launching of passive mode-locking based on a nonlinear polarization evolution, we used a highly nonlinear germanosilicate fiber (with germanium oxides concentration in the core 50 mol. %) inside the cavity and we have obtained ultrashort stretched pulses with a high peak power and energy. In this work relative intensity noise and frequency repetition stability is improved by applying isolator-polarizer (ISO-PM) with increased extinction ratio Pext and by compensation of intracavity group-velocity dispersion from the value β2 - 0.021 ps2 to - 0.0053 ps2 at 1550 nm. As a result, we have obtained the low-noise stretched pulse generation with duration 180 fs at a repetition rate 11.3 MHz (with signal-tonoise ratio at fundamental frequency 59 dB) with Allan deviation of a pulse repetition frequency for 1 s interval 5,7 * 10-9 and a relative intensity noise < -101 dBc / Hz.

  6. LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Application of the Wigner function and matrix optics to describe variations in the shape of ultrashort laser pulses propagating through linear optical systems

    NASA Astrophysics Data System (ADS)

    Gitin, Andrey V.

    2006-04-01

    The transformation of the shape of ultrashort laser pulses (USPs) in time can be described similarly to the process of image formation in space. It is shown that the wave description of imaging is simplified by using the Wigner function, this description in the quadratic approximation being identical to the use of the ABCD matrices. The transformation of USPs propagating through linear optical systems was described and these systems were classified by the methods of matrix optics.

  7. Deposition of functional nanoparticle thin films by resonant infrared laser ablation.

    NASA Astrophysics Data System (ADS)

    Haglund, Richard; Johnson, Stephen; Park, Hee K.; Appavoo, Kannatessen

    2008-03-01

    We have deposited thin films containing functional nanoparticles, using tunable infrared light from a picosecond free-electron laser (FEL). Thin films of the green light-emitting molecule Alq3 were first deposited by resonant infrared laser ablation at 6.68 μm, targeting the C=C ring mode of the Alq3. TiO2 nanoparticles 50-100 nm diameter were then suspended in a water matrix, frozen, and transferred by resonant infrared laser ablation at 2.94 μm through a shadow mask onto the Alq3 film. Photoluminescence was substantially enhanced in the regions of the film covered by the TiO2 nanoparticles. In a second experiment, gold nanoparticles with diameters in the range of 50-100 nm were suspended in the conducting polymer and anti-static coating material PEDOT:PSS, which was diluted by mixing with N-methyl pyrrolidinone (NMP). The gold nanoparticle concentration was 8-10% by weight. The mixture was frozen and then ablated by tuning the FEL to 3.47 μm, the C-H stretch mode of NMP. Optical spectroscopy of the thin film deposited by resonant infrared laser ablation exhibited the surface-plasmon resonance characteristic of the Au nanoparticles. These experiments illustrate the versatility of matrix-assisted resonant infrared laser ablation as a technique for depositing thin films containing functionalized nanoparticles.

  8. Cavity Optical Pulse Extraction: ultra-short pulse generation as seeded Hawking radiation.

    PubMed

    Eilenberger, Falk; Kabakova, Irina V; de Sterke, C Martijn; Eggleton, Benjamin J; Pertsch, Thomas

    2013-01-01

    We show that light trapped in an optical cavity can be extracted from that cavity in an ultrashort burst by means of a trigger pulse. We find a simple analytic description of this process and show that while the extracted pulse inherits its pulse length from that of the trigger pulse, its wavelength can be completely different. Cavity Optical Pulse Extraction is thus well suited for the development of ultrashort laser sources in new wavelength ranges. We discuss similarities between this process and the generation of Hawking radiation at the optical analogue of an event horizon with extremely high Hawking temperature. Our analytic predictions are confirmed by thorough numerical simulations.

  9. Improving executive function using transcranial infrared laser stimulation.

    PubMed

    Blanco, Nathaniel J; Maddox, W Todd; Gonzalez-Lima, Francisco

    2017-03-01

    Transcranial infrared laser stimulation is a new non-invasive form of low-level light therapy that may have a wide range of neuropsychological applications. It entails using low-power and high-energy-density infrared light from lasers to increase metabolic energy. Preclinical work showed that this intervention can increase cortical metabolic energy, thereby improving frontal cortex-based memory function in rats. Barrett and Gonzalez-Lima (2013, Neuroscience, 230, 13) discovered that transcranial laser stimulation can enhance sustained attention and short-term memory in humans. We extend this line of work to executive function. Specifically, we ask whether transcranial laser stimulation enhances performance in the Wisconsin Card Sorting Task that is considered the gold standard of executive function and is compromised in normal ageing and a number of neuropsychological disorders. We used a laser of a specific wavelength (1,064 nm) that photostimulates cytochrome oxidase - the enzyme catalysing oxygen consumption for metabolic energy production. Increased cytochrome oxidase activity is considered the primary mechanism of action of this intervention. Participants who received laser treatment made fewer errors and showed improved set-shifting ability relative to placebo controls. These results suggest that transcranial laser stimulation improves executive function and may have exciting potential for treating or preventing deficits resulting from neuropsychological disorders or normal ageing. © 2015 The British Psychological Society.

  10. Parametric infrared tunable laser system

    NASA Technical Reports Server (NTRS)

    Garbuny, M.; Henningsen, T.; Sutter, J. R.

    1980-01-01

    A parametric tunable infrared laser system was built to serve as transmitter for the remote detection and density measurement of pollutant, poisonous, or trace gases in the atmosphere. The system operates with a YAG:Nd laser oscillator amplifier chain which pumps a parametric tunable frequency converter. The completed system produced pulse energies of up to 30 mJ. The output is tunable from 1.5 to 3.6 micrometers at linewidths of 0.2-0.5 /cm (FWHM), although the limits of the tuning range and the narrower line crystals presently in the parametric converter by samples of the higher quality already demonstrated is expected to improve the system performance further.

  11. Fields of an ultrashort tightly focused radially polarized laser pulse in a linear response plasma

    NASA Astrophysics Data System (ADS)

    Salamin, Yousef I.

    2017-10-01

    Analytical expressions for the fields of a radially polarized, ultrashort, and tightly focused laser pulse propagating in a linear-response plasma are derived and discussed. The fields are obtained from solving the inhomogeneous wave equations for the vector and scalar potentials, linked by the Lorenz gauge, in a plasma background. First, the scalar potential is eliminated using the gauge condition, then the vector potential is synthesized from Fourier components of an initial uniform distribution of wavenumbers, and the inverse Fourier transformation is carried out term-by-term in a truncated series (finite sum). The zeroth-order term in, for example, the axial electric field component is shown to model a pulse much better than its widely used paraxial approximation counterpart. Some of the propagation characteristics of the fields are discussed and all fields are shown to have manifested the expected limits for propagation in a vacuum.

  12. Dipolar effects on propagation of ultrashort laser pulse in one-dimensional para-nitroaniline (pNA) molecules

    NASA Astrophysics Data System (ADS)

    Zhao, Ke; Li, Hong-Yu; Liu, Ji-Cai; Wang, Chuan-Kui; Luo, Yi

    2005-12-01

    The dynamic behaviour of ultrashort (femtosecond) laser pulses in a molecular medium is studied by solving the full Maxwell-Bloch equations beyond the limits of the slowly varying envelope approximation and the rotating-wave approximation under the resonant and the non-resonant conditions. A one-dimensional asymmetric charge-transfer molecule, para-nitroaniline, is used as a model molecule whose electronic properties are calculated with the time-dependent hybrid density functional theory. Under the one-photon resonant condition, 4π pulse is separated into two sub-pulses. The weight of the second-harmonic component mainly contributed by the two-photon excitation becomes stronger with longer propagation time. Under the two-photon resonant condition, the separation of 4π pulse is not induced and many higher-order spectral components beyond the second-harmonic generation occur. Interestingly, when the pulse propagates for long enough, the carrier modification becomes so significant that a continuous spectrum is generated. The Fourier transform of the high-harmonic spectrum demonstrates that an even shorter laser pulse can be produced in both resonant and non-resonant propagations. The effects of permanent dipole moments on the pulse evolution are discussed.

  13. Mid-infrared laser phase-locking to a remote near-infrared frequency reference for high-precision molecular spectroscopy

    NASA Astrophysics Data System (ADS)

    Chanteau, B.; Lopez, O.; Zhang, W.; Nicolodi, D.; Argence, B.; Auguste, F.; Abgrall, M.; Chardonnet, C.; Santarelli, G.; Darquié, B.; Le Coq, Y.; Amy-Klein, A.

    2013-07-01

    We present a method for accurate mid-infrared frequency measurements and stabilization to a near-infrared ultra-stable frequency reference, transmitted with a long-distance fibre link and continuously monitored against state-of-the-art atomic fountain clocks. As a first application, we measure the frequency of an OsO4 rovibrational molecular line around 10 μm with an uncertainty of 8 × 10-13. We also demonstrate the frequency stabilization of a mid-infrared laser with fractional stability better than 4 × 10-14 at 1 s averaging time and a linewidth below 17 Hz. This new stabilization scheme gives us the ability to transfer frequency stability in the range of 10-15 or even better, currently accessible in the near infrared or in the visible, to mid-infrared lasers in a wide frequency range.

  14. Infrared laser in the treatment of craniomandibular disorders, arthrogenous pain.

    PubMed

    Hansson, T L

    1989-05-01

    The fast removal of intra-articular inflammation of the temporomandibular joint in five different patients after infrared laser application is described. Parameters of clinical evaluation was maximum mouth opening and subjective pain. The application of infrared laser of 700 Hz frequency for 3 minutes during five consecutive days at the skin over the painful area of the temporomandibular joint was used. However, the importance of concomitant mandibular stabilization is stressed to achieve optimal result.

  15. Laser capture microdissection: Arcturus(XT) infrared capture and UV cutting methods.

    PubMed

    Gallagher, Rosa I; Blakely, Steven R; Liotta, Lance A; Espina, Virginia

    2012-01-01

    Laser capture microdissection (LCM) is a technique that allows the precise procurement of enriched cell populations from a heterogeneous tissue under direct microscopic visualization. LCM can be used to harvest the cells of interest directly or can be used to isolate specific cells by ablating the unwanted cells, resulting in histologically enriched cell populations. The fundamental components of laser microdissection technology are (a) visualization of the cells of interest via microscopy, (b) transfer of laser energy to a thermolabile polymer with either the formation of a polymer-cell composite (capture method) or transfer of laser energy via an ultraviolet laser to photovolatize a region of tissue (cutting method), and (c) removal of cells of interest from the heterogeneous tissue section. Laser energy supplied by LCM instruments can be infrared (810 nm) or ultraviolet (355 nm). Infrared lasers melt thermolabile polymers for cell capture, whereas ultraviolet lasers ablate cells for either removal of unwanted cells or excision of a defined area of cells. LCM technology is applicable to an array of applications including mass spectrometry, DNA genotyping and loss-of-heterozygosity analysis, RNA transcript profiling, cDNA library generation, proteomics discovery, and signal kinase pathway profiling. This chapter describes the unique features of the Arcturus(XT) laser capture microdissection instrument, which incorporates both infrared capture and ultraviolet cutting technology in one instrument, using a proteomic downstream assay as a model.

  16. Self-calibrating d-scan: measuring ultrashort laser pulses on-target using an arbitrary pulse compressor.

    PubMed

    Alonso, Benjamín; Sola, Íñigo J; Crespo, Helder

    2018-02-19

    In most applications of ultrashort pulse lasers, temporal compressors are used to achieve a desired pulse duration in a target or sample, and precise temporal characterization is important. The dispersion-scan (d-scan) pulse characterization technique usually involves using glass wedges to impart variable, well-defined amounts of dispersion to the pulses, while measuring the spectrum of a nonlinear signal produced by those pulses. This works very well for broadband few-cycle pulses, but longer, narrower bandwidth pulses are much more difficult to measure this way. Here we demonstrate the concept of self-calibrating d-scan, which extends the applicability of the d-scan technique to pulses of arbitrary duration, enabling their complete measurement without prior knowledge of the introduced dispersion. In particular, we show that the pulse compressors already employed in chirped pulse amplification (CPA) systems can be used to simultaneously compress and measure the temporal profile of the output pulses on-target in a simple way, without the need of additional diagnostics or calibrations, while at the same time calibrating the often-unknown differential dispersion of the compressor itself. We demonstrate the technique through simulations and experiments under known conditions. Finally, we apply it to the measurement and compression of 27.5 fs pulses from a CPA laser.

  17. Low-level infrared laser modulates muscle repair and chromosome stabilization genes in myoblasts.

    PubMed

    da Silva Neto Trajano, Larissa Alexsandra; Stumbo, Ana Carolina; da Silva, Camila Luna; Mencalha, Andre Luiz; Fonseca, Adenilson S

    2016-08-01

    Infrared laser therapy is used for skeletal muscle repair based on its biostimulative effect on satellite cells. However, shortening of telomere length limits regenerative potential in satellite cells, which occurs after each cell division cycle. Also, laser therapy could be more effective on non-physiologic tissues. This study evaluated low-level infrared laser exposure effects on mRNA expression from muscle injury repair and telomere stabilization genes in myoblasts in normal and stressful conditions. Laser fluences were those used in clinical protocols. C2C12 myoblast cultures were exposed to low-level infrared laser (10, 35, and 70 J/cm(2)) in standard or normal (10 %) and reduced (2 %) fetal bovine serum concentrations; total RNA was extracted for mRNA expression evaluation from muscle injury repair (MyoD and Pax7) and chromosome stabilization (TRF1 and TRF2) genes by real time quantitative polymerization chain reaction. Data show that low-level infrared laser increases the expression of MyoD and Pax7 in 10 J/cm(2) fluence, TRF1 expression in all fluences, and TRF2 expression in 70 J/cm(2) fluence in both 10 and 2 % fetal bovine serum. Low-level infrared laser increases mRNA expression from genes related to muscle repair and telomere stabilization in myoblasts in standard or normal and stressful conditions.

  18. Infrared technique for decoding of invisible laser markings

    NASA Astrophysics Data System (ADS)

    Haferkamp, Heinz; Jaeschke, Peter; Stein, Johannes; Goede, Martin

    2002-03-01

    Counterfeiting and product piracy continues to be an important issue not only for the Western industry, but also for the society in general. Due to the drastic increase in product imitation and the request for plagiarism protection as well as for reducing thefts there is a high interest in new protection methods providing new security features. The method presented here consists of security markings which are included below paint layers. These markings are invisible for the human eye due to the non-transparency of the upper layers in the visible spectral range. However, the markings can be detected by an infrared technique taking advantage on the partial transparency of the upper paint layers in the IR-region. Metal sheets are marked using laser radiation. The beam of a Nd:YAG-laser provides a modification of the surface structure, resulting in dark markings due to the annealing effect. After coating of the laser-marked material, the markings are invisible for the bare eye. In order to read out the invisible information below the coating, an infrared reflection technique is used. The samples are illuminated with halogen lamps or infrared radiators. Many coating materials (i. e. paints) show a certain transparency in the mid-infrared region, especially between 3 - 5 micrometers . The reflected radiation is detected using an IR-camera with a sensitivity range from 3.4 - 5 micrometers . Due to the different reflection properties between the markings and their surrounding, the information can be detected.

  19. Low-intensity infrared laser effects on zymosan-induced articular inflammatory response

    NASA Astrophysics Data System (ADS)

    Januária dos Anjos, Lúcia Mara; da Fonseca, Adenilson d. S.; Gameiro, Jacy; de Paoli, Flávia

    2015-03-01

    Low-level therapy laser is a phototherapy treatment that involves the application of low power light in the red or infrared wavelengths in various diseases such as arthritis. In this work, we investigated whether low-intensity infrared laser therapy could cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosaninduced articular inflammatory process. Inflammatory process was induced in C57BL/6 mouse by intra-articular injection of zymosan into rear tibio-tarsal joints. Thirty animals were divided in five groups: (I) control, (II) laser, (III) zymosan-induced, (IV) zymosan-induced + laser and (V). Laser exposure was performed after zymosan administration with low-intensity infrared laser (830 nm), power 10 mW, fluence 3.0 J/cm2 at continuous mode emission, in five doses. Twenty-four hours after last irradiation, the animals were sacrificed and the right joints fixed and demineralized. Morphological analysis was observed by hematoxylin and eosin stain, pro-apoptotic (caspase-6) was analyzed by immunocytochemistry and DNA fragmentation was performed by TUNEL assay in articular cartilage cells. Inflammatory process was observed in connective tissue near to articular cartilage, in IV and V groups, indicating zymosan effect. This process was decreased in both groups after laser treatment and dexamethasone. Although groups III and IV presented higher caspase-6 and DNA fragmentation percentages, statistical differences were not observed when compared to groups I and II. Our results suggest that therapies based on low-intensity infrared lasers could reduce inflammatory process and could not cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosan-induced articular inflammatory process.

  20. Cavity Optical Pulse Extraction: ultra-short pulse generation as seeded Hawking radiation

    PubMed Central

    Eilenberger, Falk; Kabakova, Irina V.; de Sterke, C. Martijn; Eggleton, Benjamin J.; Pertsch, Thomas

    2013-01-01

    We show that light trapped in an optical cavity can be extracted from that cavity in an ultrashort burst by means of a trigger pulse. We find a simple analytic description of this process and show that while the extracted pulse inherits its pulse length from that of the trigger pulse, its wavelength can be completely different. Cavity Optical Pulse Extraction is thus well suited for the development of ultrashort laser sources in new wavelength ranges. We discuss similarities between this process and the generation of Hawking radiation at the optical analogue of an event horizon with extremely high Hawking temperature. Our analytic predictions are confirmed by thorough numerical simulations. PMID:24060831

  1. Steering population transfer of the Na2 molecule by an ultrashort pulse train

    NASA Astrophysics Data System (ADS)

    Niu, Dong-Hua; Wang, Shuo; Zhan, Wei-Shen; Tao, Hong-Cai; Wang, Si-Qi

    2018-05-01

    We theoretically investigate the complete population transfer among quantum states of the Na2 molecule using ultrashort pulse trains using the time-dependent wave packet method. The population accumulation of the target state can be steered by controlling the laser parameters, such as the variable pulse pairs, the different pulse widths, the time delays and the repetition period between two contiguous pulses; in particular, the pulse pairs and the pulse widths have a great effect on the population transfer. The calculations show that the ultrashort pulse train is a feasible solution, which can steer the population transfer from the initial state to the target state efficiently with lower peak intensities.

  2. Interaction dynamics of fs-laser induced cavitation bubbles and their impact on the laser-tissue-interaction of modern ophthalmic laser systems

    NASA Astrophysics Data System (ADS)

    Tinne, N.; Ripken, T.; Lubatschowski, H.; Heisterkamp, A.

    2011-07-01

    A today well-known laser based treatment in ophthalmology is the LASIK procedure which nowadays includes cutting of the corneal tissue with ultra-short laser pulses. Instead of disposing a microkeratome for cutting a corneal flap, a focused ultra-short laser pulse is scanned below the surface of biological tissue causing the effect of an optical breakdown and hence obtaining a dissection. Inside the tissue, the energy of the laser pulses is absorbed by non-linear processes; as a result a cavitation bubble expands and ruptures the tissue. Hence, positioning of several optical breakdowns side by side generates an incision. Due to a reduction of the amount of laser energy, with a moderate duration of treatment at the same time, the current development of ultra-short pulse laser systems points to higher repetition rates in the range of even Megahertz instead of tens or hundreds of Kilohertz. In turn, this results in a pulse overlap and therefor a probable occurrence of interaction between different optical breakdowns and respectively cavitation bubbles of adjacent optical breakdowns. While the interaction of one single laser pulse with biological tissue is analyzed reasonably well experimentally and theoretically, the interaction of several spatial and temporal following pulses is scarcely determined yet. Thus, the aim of this study is to analyse the dynamic and interaction of two cavitation bubbles by using high speed photography. The applied laser pulse energy, the energy ratio and the spot distance between different cavitation bubbles were varied. Depending on a change of these parameters different kinds of interactions such as a flattening and deformation of bubble shape or jet formation are observed. The effects will be discussed regarding the medical ophthalmic application of fs-lasers. Based on these results a further research seems to be inevitable to comprehend and optimize the cutting effect of ultra-short pulse laser systems with high (> 500 kHz) repetition

  3. A review of infrared laser energy absorption and subsequent healing in the cornea

    NASA Astrophysics Data System (ADS)

    Saunders, Latica L.; Johnson, Thomas E.; Neal, Thomas A.

    2004-07-01

    The purpose of this review is to compile information on the optical and healing properties of the cornea when exposed to infrared lasers. Our long-term goal is to optimize the treatment parameters for corneal injuries after exposure to infrared laser systems. The majority of the information currently available in the literature focuses on corneal healing after therapeutic vision correction surgery with LASIK or PRK. Only a limited amount of information is available on corneal healing after injury with an infrared laser system. In this review we will speculate on infrared photon energy absorption in corneal injury and healing to include the role of the tear layer. The aim of this review is to gain a better understanding of infrared energy absorption in the cornea and how it might impact healing.

  4. Birefringence profile adjustment by spatial overlap of nanogratings induced by ultra-short laser pulses inside fused silica

    NASA Astrophysics Data System (ADS)

    Arabanian, Atoosa Sadat; Najafi, Somayeh; Ajami, Aliasghar; Husinsky, Wolfgang; Massudi, Reza

    2018-02-01

    We have succeeded in realizing a method to control the spatial distribution of optical retardation as a result of nanogratings in bulk-fused silica induced by ultrashort laser pulses. A colorimetry-based retardation measurement (CBRM) based on the Michel-Levy interference color chart using a polarization microscope is used to determine the profiles of the optical retardation. Effects of the spatial overlap of written regions as well as the energy and polarization of the writing pulses on the induced retardations are studied. It has been found that the spatial overlap of lines written by pulse trains with different energies and polarizations can result in an adjustment of the induced birefringence in the overlap region. This approach offers the possibility of designing polarization-sensitive components with a desired birefringence profile.

  5. Modeling of ultrashort pulsed laser irradiation in the cornea based on parabolic and hyperbolic heat equations using electrical analogy

    NASA Astrophysics Data System (ADS)

    Gheitaghy, A. M.; Takabi, B.; Alizadeh, M.

    2014-03-01

    Hyperbolic and parabolic heat equations are formulated to study a nonperfused homogeneous transparent cornea irradiated by high power and ultrashort pulsed laser in the Laser Thermo Keratoplasty (LTK) surgery. Energy absorption inside the cornea is modeled using the Beer-Lambert law that is incorporated as an exponentially decaying heat source. The hyperbolic and parabolic bioheat models of the tissue were solved by exploiting the mathematical analogy between thermal and electrical systems, by using robust circuit simulation program called Hspice to get the solutions of simultaneous RLC and RC transmission line networks. This method can be used to rapidly calculate the temperature in laser-irradiated tissue at time and space domain. It is found that internal energy gained from the irradiated field results in a rapid rise of temperature in the cornea surface during the early heating period, while the hyperbolic wave model predicts a higher temperature rise than the classical heat diffusion model. In addition, this paper investigates and examines the effect of some critical parameters such as relaxation time, convection coefficient, radiation, tear evaporation and variable thermal conductivity of cornea. Accordingly, it is found that a better accordance between hyperbolic and parabolic models will be achieved by time.

  6. Low-intensity red and infrared laser effects at high fluences on Escherichia coli cultures

    PubMed Central

    Barboza, L.L.; Campos, V.M.A.; Magalhães, L.A.G.; Paoli, F.; Fonseca, A.S.

    2015-01-01

    Semiconductor laser devices are readily available and practical radiation sources providing wavelength tenability and high monochromaticity. Low-intensity red and near-infrared lasers are considered safe for use in clinical applications. However, adverse effects can occur via free radical generation, and the biological effects of these lasers from unusually high fluences or high doses have not yet been evaluated. Here, we evaluated the survival, filamentation induction and morphology of Escherichia coli cells deficient in repair of oxidative DNA lesions when exposed to low-intensity red and infrared lasers at unusually high fluences. Cultures of wild-type (AB1157), endonuclease III-deficient (JW1625-1), and endonuclease IV-deficient (JW2146-1) E. coli, in exponential and stationary growth phases, were exposed to red and infrared lasers (0, 250, 500, and 1000 J/cm2) to evaluate their survival rates, filamentation phenotype induction and cell morphologies. The results showed that low-intensity red and infrared lasers at high fluences are lethal, induce a filamentation phenotype, and alter the morphology of the E. coli cells. Low-intensity red and infrared lasers have potential to induce adverse effects on cells, whether used at unusually high fluences, or at high doses. Hence, there is a need to reinforce the importance of accurate dosimetry in therapeutic protocols. PMID:26445339

  7. Dispersion engineering of mode-locked fibre lasers

    NASA Astrophysics Data System (ADS)

    Woodward, R. I.

    2018-03-01

    Mode-locked fibre lasers are important sources of ultrashort pulses, where stable pulse generation is achieved through a balance of periodic amplitude and phase evolutions. A range of distinct cavity pulse dynamics have been revealed, arising from the interplay between dispersion and nonlinearity in addition to dissipative processes such as filtering. This has led to the discovery of numerous novel operating regimes, offering significantly improved laser performance. In this Topical Review, we summarise the main steady-state pulse dynamics reported to date through cavity dispersion engineering, including average solitons, dispersion-managed solitons, dissipative solitons, giant-chirped pulses and similaritons. Characteristic features and the stabilisation mechanism of each regime are described, supported by numerical modelling, in addition to the typical performance and limitations. Opportunities for further pulse energy scaling are discussed, in addition to considering other recent advances including automated self-tuning cavities and fluoride-fibre-based mid-infrared mode-locked lasers.

  8. Integrated all-optical infrared switchable plasmonic quantum cascade laser.

    PubMed

    Kohoutek, John; Bonakdar, Alireza; Gelfand, Ryan; Dey, Dibyendu; Nia, Iman Hassani; Fathipour, Vala; Memis, Omer Gokalp; Mohseni, Hooman

    2012-05-09

    We report a type of infrared switchable plasmonic quantum cascade laser, in which far field light in the midwave infrared (MWIR, 6.1 μm) is modulated by a near field interaction of light in the telecommunications wavelength (1.55 μm). To achieve this all-optical switch, we used cross-polarized bowtie antennas and a centrally located germanium nanoslab. The bowtie antenna squeezes the short wavelength light into the gap region, where the germanium is placed. The perturbation of refractive index of the germanium due to the free carrier absorption produced by short wavelength light changes the optical response of the antenna and the entire laser intensity at 6.1 μm significantly. This device shows a viable method to modulate the far field of a laser through a near field interaction.

  9. Enhanced water window x-ray emission from in situ formed carbon clusters irradiated by intense ultra-short laser pulses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chakravarty, U.; Rao, B. S.; Arora, V.

    Enhanced water window x-ray emission (23–44 Å) from carbon clusters, formed in situ using a pre-pulse, irradiated by intense (I > 10{sup 17} W/cm{sup 2}) ultra-short laser pulse, is demonstrated. An order of magnitude x-ray enhancement over planar graphite target is observed in carbon clusters, formed by a sub-ns pre-pulse, interacting with intense main pulse after a delay. The effect of the delay and the duration of the main pulse is studied for optimizing the x-ray emission in the water window region. This x-ray source has added advantages of being an efficient, high repetition rate, and low debris x-ray source.

  10. Ultrafast Laser Interaction Processes for Libs and Other Sensing Technologies

    DTIC Science & Technology

    2013-04-05

    Wang. Propagation of ultrashort pulses through water, Optics Express, (02 2007): . doi: 12/02/2009 8.00 Z. Chen, S. Mao. Femtosecond laser -induced...Richardson, "Nd:YAG-CO2 double- pulse laser -induced breakdown spectroscopy for explosive residues detection" SPIE Defense, Security, Sensing; Orlando, FL... Ultrashort Pulse Laser Workshop, Directed Energy Professional Society; Newton, MA, USA; 06/29,2009. 63. Martin C. Richardson, Michael Sigman

  11. Transcranial infrared laser stimulation improves rule-based, but not information-integration, category learning in humans.

    PubMed

    Blanco, Nathaniel J; Saucedo, Celeste L; Gonzalez-Lima, F

    2017-03-01

    This is the first randomized, controlled study comparing the cognitive effects of transcranial laser stimulation on category learning tasks. Transcranial infrared laser stimulation is a new non-invasive form of brain stimulation that shows promise for wide-ranging experimental and neuropsychological applications. It involves using infrared laser to enhance cerebral oxygenation and energy metabolism through upregulation of the respiratory enzyme cytochrome oxidase, the primary infrared photon acceptor in cells. Previous research found that transcranial infrared laser stimulation aimed at the prefrontal cortex can improve sustained attention, short-term memory, and executive function. In this study, we directly investigated the influence of transcranial infrared laser stimulation on two neurobiologically dissociable systems of category learning: a prefrontal cortex mediated reflective system that learns categories using explicit rules, and a striatally mediated reflexive learning system that forms gradual stimulus-response associations. Participants (n=118) received either active infrared laser to the lateral prefrontal cortex or sham (placebo) stimulation, and then learned one of two category structures-a rule-based structure optimally learned by the reflective system, or an information-integration structure optimally learned by the reflexive system. We found that prefrontal rule-based learning was substantially improved following transcranial infrared laser stimulation as compared to placebo (treatment X block interaction: F(1, 298)=5.117, p=0.024), while information-integration learning did not show significant group differences (treatment X block interaction: F(1, 288)=1.633, p=0.202). These results highlight the exciting potential of transcranial infrared laser stimulation for cognitive enhancement and provide insight into the neurobiological underpinnings of category learning. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Dynamics of bulk electron heating and ionization in solid density plasmas driven by ultra-short relativistic laser pulses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huang, L. G., E-mail: lingen.huang@hzdr.de; Kluge, T.; Cowan, T. E.

    The dynamics of bulk heating and ionization is investigated both in simulations and theory, which determines the crucial plasma parameters such as plasma temperature and density in ultra-short relativistic laser-solid target interactions. During laser-plasma interactions, the solid density plasma absorbs a fraction of laser energy and converts it into kinetic energy of electrons. A portion of the electrons with relativistic kinetic energy goes through the solid density plasma and transfers energy into the bulk electrons, which results in bulk electron heating. The bulk electron heating is finally translated into the processes of bulk collisional ionization inside the solid target. Amore » simple model based on the Ohmic heating mechanism indicates that the local and temporal profile of bulk return current is essential to determine the temporal evolution of bulk electron temperature. A series of particle-in-cell simulations showing the local heating model is robust in the cases of target with a preplasma and without a preplasma. Predicting the bulk electron heating is then benefit for understanding the collisional ionization dynamics inside the solid targets. The connection of the heating and ionization inside the solid target is further studied using Thomas-Fermi model.« less

  13. Low-intensity infrared lasers alter actin gene expression in skin and muscle tissue

    NASA Astrophysics Data System (ADS)

    Fonseca, A. S.; Mencalha, A. L.; Campos, V. M. A.; Ferreira-Machado, S. C.; Peregrino, A. A. F.; Magalhães, L. A. G.; Geller, M.; Paoli, F.

    2013-02-01

    The biostimulative effect of low-intensity lasers is the basis for treatment of diseases in soft tissues. However, data about the influence of biostimulative lasers on gene expression are still scarce. The aim of this work was to evaluate the effects of low-intensity infrared lasers on the expression of actin mRNA in skin and muscle tissue. Skin and muscle tissue of Wistar rats was exposed to low-intensity infrared laser radiation at different fluences and frequencies. One and 24 hours after laser exposure, tissue samples were withdrawn for total RNA extraction, cDNA synthesis and evaluation of actin gene expression by quantitative polymerase chain reaction. The data obtained show that laser radiation alters the expression of actin mRNA differently in skin and muscle tissue of Wistar rats depending of the fluence, frequency and time after exposure. The results could be useful for laser dosimetry, as well as to justify the therapeutic protocols for treatment of diseases of skin and muscle tissues based on low-intensity infrared laser radiation.

  14. The edge detection method of the infrared imagery of the laser spot

    NASA Astrophysics Data System (ADS)

    Che, Jinxi; Zhang, Jinchun; Li, Zhongmin

    2016-01-01

    In the jamming effectiveness experiments, in which the thermal infrared imager was interfered by the CO2 Laser, in order to evaluate the jamming effect of the thermal infrared imager by the CO2 Laser, it was needed to analyses the obtained infrared imagery of laser spot. Because the laser spot pictures obtained from the thermal infrared imager are irregular, the edge detection is an important process. The image edge is one of the most basic characteristics of the image, and it contains most of the information of the image. Generally, because of the thermal balance effect, the partly temperature of objective is no quite difference; therefore the infrared imagery's ability of reflecting the local detail of object is obvious week. At the same time, when the information of heat distribution of the thermal imagery was combined with the basic information of target, such as the object size, the relative position of field of view, shape and outline, and so on, the information just has more value. Hence, it is an important step for making image processing to extract the objective edge of the infrared imagery. Meanwhile it is an important part of image processing procedure and it is the premise of many subsequent processing. So as to extract outline information of the target from the original thermal imagery, and overcome the disadvantage, such as the low image contrast of the image and serious noise interference, and so on, the edge of thermal imagery needs detecting and processing. The principles of the Roberts, Sobel, Prewitt and Canny operator were analyzed, and then they were used to making edge detection on the thermal imageries of laser spot, which were obtained from the jamming effect experiments of CO2 laser jamming the thermal infrared imager. On the basis of the detection result, their performances were compared. At the end, the characteristics of the operators were summarized, which provide reference for the choice of edge detection operators in thermal imagery

  15. Self similar solution of superradiant amplification of ultrashort laser pulses in plasma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moghadasin, H.; Niknam, A. R., E-mail: a-niknam@sbu.ac.ir; Shokri, B.

    2015-05-15

    Based on the self-similar method, superradiant amplification of ultrashort laser pulses by the counterpropagating pump in a plasma is investigated. Here, we present a governing system of partial differential equations for the signal pulse and the motion of the electrons. These equations are transformed to ordinary differential equations by the self-similar method and numerically solved. It is found that the increase of the signal intensity is proportional to the square of the propagation distance and the signal frequency has a red shift. Also, depending on the pulse width, the signal breaks up into a train of short pulses or itsmore » duration decreases with the inverse square root of the distance. Moreover, we identified two distinct categories of the electrons by the phase space analysis. In the beginning, one of them is trapped in the ponderomotive potential well and oscillates while the other is untrapped. Over time, electrons of the second kind also join to the trapped electrons. In the potential well, the electrons are bunched to form an electron density grating which reflects the pump pulse into the signal pulse. It is shown that the backscattered intensity is enhanced with the increase of the electron bunching parameter which leads to the enhanced efficiency of superradiant amplification.« less

  16. Dynamic target ionization using an ultrashort pulse of a laser field

    NASA Astrophysics Data System (ADS)

    Makarov, D. N.; Matveev, V. I.; Makarova, K. A.

    2014-09-01

    Ionization processes under the interaction of an ultrashort pulse of an electromagnetic field with atoms in nonstationary states are considered. As an example, the ionization probability of the hydrogen-like atom upon the decay of quasi-stationary state is calculated. The method developed can be applied to complex systems, including targets in collisional states and various chemical reactions.

  17. High-speed high-sensitivity infrared spectroscopy using mid-infrared swept lasers (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Childs, David T. D.; Groom, Kristian M.; Hogg, Richard A.; Revin, Dmitry G.; Cockburn, John W.; Rehman, Ihtesham U.; Matcher, Stephen J.

    2016-03-01

    Infrared spectroscopy is a highly attractive read-out technology for compositional analysis of biomedical specimens because of its unique combination of high molecular sensitivity without the need for exogenous labels. Traditional techniques such as FTIR and Raman have suffered from comparatively low speed and sensitivity however recent innovations are challenging this situation. Direct mid-IR spectroscopy is being speeded up by innovations such as MEMS-based FTIR instruments with very high mirror speeds and supercontinuum sources producing very high sample irradiation levels. Here we explore another possible method - external cavity quantum cascade lasers (EC-QCL's) with high cavity tuning speeds (mid-IR swept lasers). Swept lasers have been heavily developed in the near-infrared where they are used for non-destructive low-coherence imaging (OCT). We adapt these concepts in two ways. Firstly by combining mid-IR quantum cascade gain chips with external cavity designs adapted from OCT we achieve spectral acquisition rates approaching 1 kHz and demonstrate potential to reach 100 kHz. Secondly we show that mid-IR swept lasers share a fundamental sensitivity advantage with near-IR OCT swept lasers. This makes them potentially able to achieve the same spectral SNR as an FTIR instrument in a time x N shorter (N being the number of spectral points) under otherwise matched conditions. This effect is demonstrated using measurements of a PDMS sample. The combination of potentially very high spectral acquisition rates, fundamental SNR advantage and the use of low-cost detector systems could make mid-IR swept lasers a powerful technology for high-throughput biomedical spectroscopy.

  18. Involvement of small carbon clusters in the enhancement of high-order harmonic generation of ultrashort pulses in the plasmas produced during ablation of carbon-contained nanoparticles

    NASA Astrophysics Data System (ADS)

    Ganeev, R. A.

    2017-09-01

    Various carbon-based nanoparticles ablated at the conditions suitable for efficient harmonic generation during propagation of ultrashort pulses through the laser-produced plasmas were studied. The transmission electron microscopy of ablated debris and the time-of-flight mass-spectroscopy studies of plasmas are presented. The conditions of laser ablation of the carbon-contained nanoparticles (fullerenes, graphene, carbon nanotubes, carbon nanofibers, and diamond nanoparticles) were varied to define the impeding processes restricting the harmonic yield from such laser-produced plasmas. These studies show that the enhancement of harmonics during ablation of nanoparticle targets was related with the appearance of small carbon clusters at the moment of propagation of the ultrashort laser pulses though such plasmas.

  19. Table-top laser-driven ultrashort electron and X-ray source: the CIBER-X source project

    NASA Astrophysics Data System (ADS)

    Girardeau-Montaut, Jean-Pierre; Kiraly, Bélà; Girardeau-Montaut, Claire; Leboutet, Hubert

    2000-09-01

    We report on the development of a new laser-driven table-top ultrashort electron and X-ray source, also called the CIBER-X source . X-ray pulses are produced by a three-step process which consists of the photoelectron emission from a thin metallic photocathode illuminated by 16 ps duration laser pulses at 213 nm. The e-gun is a standard Pierce diode electrode type, in which electrons are accelerated by a cw electric field of ˜11 MV/m up to a hole made in the anode. The photoinjector produces a train of 70-80 keV electron pulses of ˜0.5 nC and 20 A peak current at a repetition rate of 10 Hz. The electrons are then transported outside the diode along a path of 20 cm length, and are focused onto a target of thullium by magnetic fields produced by two electromagnetic coils. X-rays are then produced by the impact of electrons on the target. Simulations of geometrical, electromagnetic fields and energetic characteristics of the complete source were performed previously with the assistance of the code PIXEL1 also developed at the laboratory. Finally, experimental electron and X-ray performances of the CIBER-X source as well as its application to very low dose imagery are presented and discussed. source Compacte d' Impulsions Brèves d' Electrons et de Rayons X

  20. Doping of germanium and silicon crystals with non-hydrogenic acceptors for far infrared lasers

    DOEpatents

    Haller, Eugene E.; Brundermann, Erik

    2000-01-01

    A method for doping semiconductors used for far infrared lasers with non-hydrogenic acceptors having binding energies larger than the energy of the laser photons. Doping of germanium or silicon crystals with beryllium, zinc or copper. A far infrared laser comprising germanium crystals doped with double or triple acceptor dopants permitting the doped laser to be tuned continuously from 1 to 4 terahertz and to operate in continuous mode. A method for operating semiconductor hole population inversion lasers with a closed cycle refrigerator.

  1. Advancements in quantum cascade laser-based infrared microscopy of aqueous media.

    PubMed

    Haase, K; Kröger-Lui, N; Pucci, A; Schönhals, A; Petrich, W

    2016-06-23

    The large mid-infrared absorption coefficient of water frequently hampers the rapid, label-free infrared microscopy of biological objects in their natural aqueous environment. However, the high spectral power density of quantum cascade lasers is shifting this limitation such that mid-infrared absorbance images can be acquired in situ within signal-to-noise ratios of up to 100. Even at sample thicknesses well above 50 μm, signal-to-noise ratios above 10 are readily achieved. The quantum cascade laser-based microspectroscopy of aqueous media is exemplified by imaging an aqueous yeast solution and quantifying glucose consumption, ethanol generation as well as the production of carbon dioxide gas during fermentation.

  2. Ultrashort pulsed laser ablation for decollation of solid state lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Hördemann, C.; Anand, H.; Gillner, A.

    2017-08-01

    Rechargeable lithium-ion batteries with liquid electrolytes are the main energy source for many electronic devices that we use in our everyday lives. However, one of the main drawbacks of this energy storage technology is the use of liquid electrolyte, which can be hazardous to the user as well as the environment. Moreover, lithium-ion batteries are limited in voltage, energy density and operating temperature range. One of the most novel and promising battery technologies available to overcome the above-mentioned drawbacks is the Solid-State Lithium-Ion Battery (SSLB). This battery type can be produced without limitations to the geometry and is also bendable, which is not possible with conventional batteries1 . Additionally, SSLBs are characterized by high volumetric and gravimetric energy density and are intrinsically safe since no liquid electrolyte is used2-4. Nevertheless, the manufacturing costs of these batteries are still high. The existing production-technologies are comparable to the processes used in the semiconductor industry and single cells are produced in batches with masked-deposition at low deposition rates. In order to decrease manufacturing costs and to move towards continuous production, Roll2Roll production methods are being proposed5, 6. These methods offer the possibility of producing large quantities of substrates with deposited SSLB-layers. From this coated substrate, single cells can be cut out. For the flexible decollation of SSLB-cells from the substrate, new manufacturing technologies have to be developed since blade-cutting, punching or conventional laser-cutting processes lead to short circuiting between the layers. Here, ultra-short pulsed laser ablation and cutting allows the flexible decollation of SSLBs. Through selective ablation of individual layers, an area for the cutting kerf is prepared to ensure a shortcut-free decollation.

  3. Infrared heterodyne spectroscopy for astronomical purposes. [laser applications

    NASA Technical Reports Server (NTRS)

    Townes, C. H.

    1978-01-01

    Heterodyne infrared astronomy was carried out using CO2 lasers and some solid state tunable lasers. The best available detectors are mercury cadmium telluride photodiodes. Their quantum efficiencies reach values near 0.5 and in an overall system an effective quantum efficiency, taking into account optical losses and amplifier noise, of about 0.25 was demonstrated. Initial uses of 10 micron heterodyne spectroscopy were for the study of planetary molecular spectra.

  4. Detailed Experimental Study of Ion Acceleration by Interaction of an Ultra-Short Intense Laser with an Underdense Plasma

    PubMed Central

    Kahaly, S.; Sylla, F.; Lifschitz, A.; Flacco, A.; Veltcheva, M.; Malka, V.

    2016-01-01

    Ion acceleration from intense (Iλ2 > 1018 Wcm−2 μm2) laser-plasma interaction is experimentally studied within a wide range of He gas densities. Focusing an ultrashort pulse (duration  ion plasma period) on a newly designed submillimetric gas jet system, enabled us to inhibit total evacuation of electrons from the central propagation channel reducing the radial ion acceleration associated with ponderomotive Coulomb explosion, a mechanism predominant in the long pulse scenario. New ion acceleration mechanism have been unveiled in this regime leading to non-Maxwellian quasi monoenergetic features in the ion energy spectra. The emitted nonthermal ion bunches show a new scaling of the ion peak energy with plasma density. The scaling identified in this new regime differs from previously reported studies. PMID:27531755

  5. Quantum Cascade Lasers in Biomedical Infrared Imaging.

    PubMed

    Bird, Benjamin; Baker, Matthew J

    2015-10-01

    Technological advances, namely the integration of quantum cascade lasers (QCLs) within an infrared (IR) microscope, are enabling the development of valuable label-free biomedical-imaging tools capable of targeting and detecting salient chemical species within practical clinical timeframes. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Ultrashort laser-matter interaction at moderate intensities: two-temperature relaxation, foaming of stretched melt, and freezing of evolving nanostructures

    NASA Astrophysics Data System (ADS)

    Inogamov, Nail A.; Zhakhovsky, Vasily V.; Petrov, Yurii V.; Khokhlov, Viktor A.; Ashitkov, Sergey I.; Migdal, Kirill P.; Ilnitsky, Denis K.; Emirov, Yusuf N.; Khishchenko, Konstantin V.; Komarov, Pavel S.; Shepelev, Vadim V.; Agranat, Mikhail B.; Anisimov, Sergey I.; Oleynik, Ivan I.; Fortov, Vladimir E.

    2013-11-01

    Interaction of ultrashort laser pulse with metals is considered. Ultrafast heating in our range of absorbed fluences Fabs > 10 mJjcm2 transfers matter into two-temperature (2T) state and induces expressed thermomechani­ cal response. To analyze our case, where 2T, thermomechanical, and multidimensional (formation of surface structures) effects are significant, we use density functional theory (DFT), solutions of kinetic equations in τ- approximation, 2T-hydrodynamics, and molecular dynamics simulations. We have studied transition from light absorption in a skin layer to 2T state, and from 2T stage to hydrodynamical motions. We describe (i) formation of very peculiar (superelasticity) acoustic wave irradiated from the laser heated surface layer and (ii) rich com­ plex of surface phenomena including fast melting, nucleation of seed bubbles in hydrodynamically stretched fluid, evolution of vapor-liquid mixture into very spatially extended foam, mechanical breaking of liquid membranes in foam (foam disintegration), strong surface tension oscillations driven by breaking of membranes, non-equilibrium freezing of overcooled molten metals, transition to nano-domain solid, and formation of surface nanostructures.

  7. Supercomputations and big-data analysis in strong-field ultrafast optical physics: filamentation of high-peak-power ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Voronin, A. A.; Panchenko, V. Ya; Zheltikov, A. M.

    2016-06-01

    High-intensity ultrashort laser pulses propagating in gas media or in condensed matter undergo complex nonlinear spatiotemporal evolution where temporal transformations of optical field waveforms are strongly coupled to an intricate beam dynamics and ultrafast field-induced ionization processes. At the level of laser peak powers orders of magnitude above the critical power of self-focusing, the beam exhibits modulation instabilities, producing random field hot spots and breaking up into multiple noise-seeded filaments. This problem is described by a (3  +  1)-dimensional nonlinear field evolution equation, which needs to be solved jointly with the equation for ultrafast ionization of a medium. Analysis of this problem, which is equivalent to solving a billion-dimensional evolution problem, is only possible by means of supercomputer simulations augmented with coordinated big-data processing of large volumes of information acquired through theory-guiding experiments and supercomputations. Here, we review the main challenges of supercomputations and big-data processing encountered in strong-field ultrafast optical physics and discuss strategies to confront these challenges.

  8. Ultrafast lasers for precise and corrosion free marking on chirurgical steels

    NASA Astrophysics Data System (ADS)

    Neugebauer, Christoph; Aalderink, Dennis; Maurer, Erich; Faisst, Birgit; Budnicki, Aleksander

    2017-02-01

    The unique properties of ultrashort laser pulses and the decrease of invest pave the way to numerous novel applications. Even in the very price sensitive field of laser marking, ultrashort laser can compete due to a new cost structure and remarkable properties of the marking results. In this study we concentrated on industrial marking of medical equipment by using IR ultrashort lasers and compared the results with common marking laser systems. We demonstrate the benefits of ultrashort lasers marking on chirurgical devices, observing the influence of pulse energy, pulse duration, scanning velocity in respect to the visibility, corrosion resistance and long term durability under clinical conditions. Nowadays many parts and products are marked for the purpose of identification and traceability. One kind of laser marking is the well known annealing of stainless steel by nanosecond marking lasers. When annealing occurs a colored oxide layer grows due to the local heating of the material surface. Compared to the raw material, the annealed marking shows increased corrosion sensitivity. Regarding the traceability, the poor durability of the ns marking resulting in contrast reduction and the corrosion susceptibility are a huge problem. Therefore three different laser sources with ns-psfs pulse duration were observed. The focus rests on the realization of parameter studies (various lasers) and their effect on the corrosion and passivation behavior. Furthermore analysis of the oxide layers by use of EDX and XRD were performed to obtain further information on the composition and structure of the markings.

  9. Neon in ultrashort and intense x-rays from free electron lasers

    NASA Astrophysics Data System (ADS)

    Buth, Christian; Beerwerth, Randolf; Obaid, Razib; Berrah, Nora; Cederbaum, Lorenz S.; Fritzsche, Stephan

    2018-03-01

    We theoretically examine neon atoms in ultrashort and intense x-rays from free electron lasers and compare our results with data from experiments conducted at the Linac Coherent Light Source. For this purpose, we treat in detail the electronic structure in all possible nonrelativistic cationic configurations using a relativistic multiconfiguration approach. The interaction with the x-rays is described in rate-equation approximation. To understand the mechanisms of the interaction, a path analysis is devised which allows us to investigate what sequences of photoionization and decay processes lead to a specific configuration and with what probability. Thereby, we uncover a connection to the mathematics of graph theory and formal languages. In detail, we study the ion yields and find that plain rate equations do not provide a satisfactory description. We need to extend the rate equations for neon to incorporate double Auger decay of a K-shell vacancy and photoionization shake off for neutral neon. Shake off is included for valence and core ionization; the former has hitherto been overlooked but has important consequences for the ion yields from an x-ray energy below the core ionization threshold. Furthermore, we predict the photon yields from XUV and x-ray fluorescence these allow one insights into the configurations populated by the interaction with the x-rays. Finally, we discover that inaccuracies in those Auger decay widths employed in previous studies have only a minor influence on ion and photon yields.

  10. DNA fragmentation and nuclear phenotype in tendons exposed to low-intensity infrared laser

    NASA Astrophysics Data System (ADS)

    de Paoli, Flavia; Ramos Cerqueira, Larissa; Martins Ramos, Mayara; Campos, Vera M.; Ferreira-Machado, Samara C.; Geller, Mauro; de Souza da Fonseca, Adenilson

    2015-03-01

    Clinical protocols are recommended in device guidelines outlined for treating many diseases on empirical basis. However, effects of low-intensity infrared lasers at fluences used in clinical protocols on DNA are controversial. Excitation of endogenous chromophores in tissues and free radicals generation could be described as a consequence of laser used. DNA lesions induced by free radicals cause changes in DNA structure, chromatin organization, ploidy degrees and cell death. In this work, we investigated whether low-intensity infrared laser therapy could alter the fibroblasts nuclei characteristics and induce DNA fragmentation. Tendons of Wistar rats were exposed to low-intensity infrared laser (830 nm), at different fluences (1, 5 and 10 J/cm2), in continuous wave (power output of 10mW, power density of 79.6 mW/cm2). Different frequencies were analyzed for the higher fluence (10 J/cm2), at pulsed emission mode (2.5, 250 and 2500 Hz), with the laser source at surface of skin. Geometric, densitometric and textural parameters obtained for Feulgen-stained nuclei by image analysis were used to define nuclear phenotypes. Significant differences were observed on the nuclear phenotype of tendons after exposure to laser, as well as, high cell death percentages was observed for all fluences and frequencies analyzed here, exception 1 J/cm2 fluence. Our results indicate that low-intensity infrared laser can alter geometric, densitometric and textural parameters in tendon fibroblasts nuclei. Laser can also induce DNA fragmentation, chromatin lost and consequently cell death, using fluences, frequencies and emission modes took out from clinical protocols.

  11. Attosecond time-energy structure of X-ray free-electron laser pulses

    NASA Astrophysics Data System (ADS)

    Hartmann, N.; Hartmann, G.; Heider, R.; Wagner, M. S.; Ilchen, M.; Buck, J.; Lindahl, A. O.; Benko, C.; Grünert, J.; Krzywinski, J.; Liu, J.; Lutman, A. A.; Marinelli, A.; Maxwell, T.; Miahnahri, A. A.; Moeller, S. P.; Planas, M.; Robinson, J.; Kazansky, A. K.; Kabachnik, N. M.; Viefhaus, J.; Feurer, T.; Kienberger, R.; Coffee, R. N.; Helml, W.

    2018-04-01

    The time-energy information of ultrashort X-ray free-electron laser pulses generated by the Linac Coherent Light Source is measured with attosecond resolution via angular streaking of neon 1s photoelectrons. The X-ray pulses promote electrons from the neon core level into an ionization continuum, where they are dressed with the electric field of a circularly polarized infrared laser. This induces characteristic modulations of the resulting photoelectron energy and angular distribution. From these modulations we recover the single-shot attosecond intensity structure and chirp of arbitrary X-ray pulses based on self-amplified spontaneous emission, which have eluded direct measurement so far. We characterize individual attosecond pulses, including their instantaneous frequency, and identify double pulses with well-defined delays and spectral properties, thus paving the way for X-ray pump/X-ray probe attosecond free-electron laser science.

  12. [Observation of carbon-bear free radicals using far infrared laser magnetic resonance spectroscopy].

    PubMed

    Huang, Guang-ming; Shi, Li-hua; Cai, Xin; Liu, Yu-yan

    2003-06-01

    The principle and technical characters of far infrared laser magnetic resonance (FIRLMR) spectrometer built up in China are introduced. A CO2 transversely pumped far infrared laser is adopted. In order to obtain high sensitivity, the sample absorption cell is placed in the FIR laser cavity and separated from laser gain cavity with thin polypropylene film. The spectrometer can be employed to study short lived free radicals. The spectra of many transient free radicals including CCH, CF and CH2 have been detected by the spectrometer. These transients are generated by mixing CH4 with the fluorine atoms produced with microwave discharge.

  13. Nonsequential double ionization with mid-infrared laser fields

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Ying -Bin; Wang, Xu; Yu, Ben -Hai

    Using a full-dimensional Monte Carlo classical ensemble method, we present a theoretical study of atomic nonsequential double ionization (NSDI) with mid-infrared laser fields, and compare with results from near-infrared laser fields. Unlike single-electron strong-field processes, double ionization shows complex and unexpected interplays between the returning electron and its parent ion core. As a result of these interplays, NSDI for mid-IR fields is dominated by second-returning electron trajectories, instead of first-returning trajectories for near-IR fields. Here, some complex NSDI channels commonly happen with near-IR fields, such as the recollision-excitation-with-subsequent-ionization (RESI) channel, are virtually shut down by mid-IR fields. Besides, the finalmore » energies of the two electrons can be extremely unequal, leading to novel e-e momentum correlation spectra that can be measured experimentally.« less

  14. Nonsequential double ionization with mid-infrared laser fields

    DOE PAGES

    Li, Ying -Bin; Wang, Xu; Yu, Ben -Hai; ...

    2016-11-18

    Using a full-dimensional Monte Carlo classical ensemble method, we present a theoretical study of atomic nonsequential double ionization (NSDI) with mid-infrared laser fields, and compare with results from near-infrared laser fields. Unlike single-electron strong-field processes, double ionization shows complex and unexpected interplays between the returning electron and its parent ion core. As a result of these interplays, NSDI for mid-IR fields is dominated by second-returning electron trajectories, instead of first-returning trajectories for near-IR fields. Here, some complex NSDI channels commonly happen with near-IR fields, such as the recollision-excitation-with-subsequent-ionization (RESI) channel, are virtually shut down by mid-IR fields. Besides, the finalmore » energies of the two electrons can be extremely unequal, leading to novel e-e momentum correlation spectra that can be measured experimentally.« less

  15. Low-intensity red and infrared lasers on XPA and XPC gene expression

    NASA Astrophysics Data System (ADS)

    Fonseca, A. S.; Magalhães, L. A. G.; Mencalha, A. L.; Ferreira-Machado, S. C.; Geller, M.; Paoli, F.

    2014-09-01

    Laser devices emit monochromatic, coherent, and highly collimated intense beams of light that are useful for a number of biomedical applications. However, for low-intensity lasers, possible adverse effects of laser light on DNA are still controversial. In this work, the expression of XPA and XPC genes in skin and muscle tissue exposed to low-intensity red and infrared lasers was evaluated. Skin and muscle tissue of Wistar rats were exposed to low-intensity red and infrared lasers at different fluences in continuous mode emission. Skin and muscle tissue samples were withdrawn for total RNA extraction, cDNA synthesis, and evaluation of actin gene expression by quantitative polymerase chain reaction. Data obtained show that laser radiation alters the expression of XPA and XPC mRNA differently in skin and muscle tissue of Wistar rats, depending on physical (fluence and wavelength) and biological (tissue) parameters. Laser light could modify expression of genes related to the nucleotide excision repair pathway at fluences and wavelengths used in clinical protocols.

  16. Laser cutting of bone tissue under bulk water with a pulsed ps-laser at 532 nm.

    PubMed

    Tulea, Cristian-Alexander; Caron, Jan; Gehlich, Nils; Lenenbach, Achim; Noll, Reinhard; Loosen, Peter

    2015-10-01

    Hard-tissue ablation was already investigated for a broad variety of pulsed laser systems, which cover almost the entire range of available wavelengths and pulse parameters. Most effective in hard-tissue ablation are Er:YAG and CO2 lasers, both utilizing the effect of absorption of infrared wavelengths by water and so-called explosive vaporization, when a thin water film or water–air spray is supplied. The typical flow rates and the water layer thicknesses are too low for surgical applications where bleeding occurs and wound flushing is necessary. We studied a 20 W ps-laser with 532 nm wavelength and a pulse energy of 1 mJ to effectively ablate bones that are submerged 14 mm under water. For these laser parameters, the plasma-mediated ablation mechanism is dominant. Simulations based on the blow-off model predict the cut depth and cross-sectional shape of the incision. The model is modified considering the cross section of the Gaussian beam, the incident angle, and reflections. The ablation rate amounts to 0.2  mm3/s, corresponding to an increase by at least 50% of the highest values published so far for ultrashort laser ablation of hard tissue.

  17. Spectroscopic Study of Terahertz Generation in Mid-Infrared Quantum Cascade Lasers.

    PubMed

    Jiang, Yifan; Vijayraghavan, Karun; Jung, Seungyong; Jiang, Aiting; Kim, Jae Hyun; Demmerle, Frederic; Boehm, Gerhard; Amann, Markus C; Belkin, Mikhail A

    2016-02-16

    Terahertz quantum cascade laser sources based on intra-cavity difference-frequency generation are currently the only room-temperature mass-producible diode-laser-like emitters of coherent 1-6 THz radiation. Device performance has improved dramatically over the past few years to reach milliwatt-level power output and broad tuning from 1.2 to 5.9 THz, all at room-temperature. Terahertz output in these sources originates from intersubband optical nonlinearity in the laser active region. Here we report the first comprehensive spectroscopic study of the optical nonlinearity and investigate its dependence on the mid-infrared pump frequencies. Our work shows that the terahertz generation efficiency can vary by a factor of 2 or greater depending on the spectral position of the mid-infrared pumps for a fixed THz difference-frequency. We have also measured for the first time the linewidth for transitions between the lower quantum cascade laser states, which is critical for determining terahertz nonlinearity and predicting optical loss in quantum cascade laser waveguides.

  18. New solid state lasers from the ultraviolet to the mid-infrared

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Payne, S.A.; Krupke, W.F.; Beach, R.J.

    The authors discuss three new laser materials that offer improved access to the ultraviolet, near infrared and mid-infrared spectral regions. In order for each of these materials to have been identified, a particular hurdle needed to be overcome with respect to the fundamental laser physics impacting the material. In the case of the 280-320nm Ce:LiSAF laser, the main issue is the need to reduce the loss associated with excited state absorption, while for 1047nm Yb:S-FAP it is the ground state absorption at the laser wavelength that must be minimized. Cr:ZnSe has been down-selected from a number of potential candidates whichmore » could lase in the 2200-3000nm region, in order to mitigate the detrimental impact of nonradiative decay. In all three cases the authors discuss how appropriate consideration of fundamental concerns has led to the identification and understanding of the new laser system.« less

  19. Mid-infrared coronary laser angioplasty with multifiber catheters

    NASA Astrophysics Data System (ADS)

    White, Christopher J.; Ramee, Stephen R.; Collins, Tyrone J.

    1993-06-01

    Mid-infrared laser wavelengths offer advantages as a source for coronary angioplasty based upon the excellent fiberoptic transmission and the enhanced tissue absorption of these photons. We report the results of a pilot clinical trial of a Holmium:YAG (2.1 micrometers ) coronary laser angioplasty using a prototype (1.6 mm and 2.0 mm) multifiber catheters. Coronary laser angioplasty with or without adjunctive balloon angioplasty or directional atherectomy was performed in 14 patients with 17 coronary stenoses. Laser success was obtained in 13/14 (93%) patients and 16/17 (94%) lesions. Uncomplicated procedural success was achieved in 9/14 (64%) patients and 12/17 (71%) lesions. Our initial laser success rate was very encouraging using this prototype multifiber catheter with a holmium:YAG laser. However, our overall procedural success rate was disappointing, and not superior to that expected with conventional angioplasty alone. The holmium laser remains an attractive energy source for laser angioplasty, but its utility is limited by catheters which create inadequate channels for stand-alone laser angioplasty.

  20. Short infrared laser pulses increase cell membrane fluidity

    NASA Astrophysics Data System (ADS)

    Walsh, Alex J.; Cantu, Jody C.; Ibey, Bennett L.; Beier, Hope T.

    2017-02-01

    Short infrared laser pulses induce a variety of effects in cells and tissues, including neural stimulation and inhibition. However, the mechanism behind these physiological effects is poorly understood. It is known that the fast thermal gradient induced by the infrared light is necessary for these biological effects. Therefore, this study tests the hypothesis that the fast thermal gradient induced in a cell by infrared light exposure causes a change in the membrane fluidity. To test this hypothesis, we used the membrane fluidity dye, di-4-ANEPPDHQ, to investigate membrane fluidity changes following infrared light exposure. Di-4-ANEPPDHQ fluorescence was imaged on a wide-field fluorescence imaging system with dual channel emission detection. The dual channel imaging allowed imaging of emitted fluorescence at wavelengths longer and shorter than 647 nm for ratiometric assessment and computation of a membrane generalized polarization (GP) value. Results in CHO cells show increased membrane fluidity with infrared light pulse exposure and this increased fluidity scales with infrared irradiance. Full recovery of pre-infrared exposure membrane fluidity was observed. Altogether, these results demonstrate that infrared light induces a thermal gradient in cells that changes membrane fluidity.

  1. Heat generation caused by ablation of dental hard tissues with an ultrashort pulse laser (USPL) system.

    PubMed

    Braun, Andreas; Krillke, Raphael Franz; Frentzen, Matthias; Bourauel, Christoph; Stark, Helmut; Schelle, Florian

    2015-02-01

    Heat generation during the removal of dental hard tissues may lead to a temperature increase and cause painful sensations or damage dental tissues. The aim of this study was to assess heat generation in dental hard tissues following laser ablation using an ultrashort pulse laser (USPL) system. A total of 85 specimens of dental hard tissues were used, comprising 45 specimens of human dentine evaluating a thickness of 1, 2, and 3 mm (15 samples each) and 40 specimens of human enamel with a thickness of 1 and 2 mm (20 samples each). Ablation was performed with an Nd:YVO4 laser at 1,064 nm, a pulse duration of 9 ps, and a repetition rate of 500 kHz with an average output power of 6 W. Specimens were irradiated for 0.8 s. Employing a scanner system, rectangular cavities of 1-mm edge length were generated. A temperature sensor was placed at the back of the specimens, recording the temperature during the ablation process. All measurements were made employing a heat-conductive paste without any additional cooling or spray. Heat generation during laser ablation depended on the dental hard tissue (enamel or dentine) and the thickness of the respective tissue (p < 0.05). Highest temperature increase could be observed in the 1-mm thickness group for enamel. Evaluating the 1-mm group for dentine, a significantly lower temperature increase could be measured (p < 0.05) with lowest values in the 3-mm group (p < 0.05). A time delay for temperature increase during the ablation process depending on the material thickness was observed for both hard tissues (p < 0.05). Employing the USPL system to remove dental hard tissues, heat generation has to be considered. Especially during laser ablation next to pulpal tissues, painful sensations and potential thermal injury of pulp tissue might occur.

  2. Spatiotemporal mode-locking in multimode fiber lasers

    NASA Astrophysics Data System (ADS)

    Wright, Logan G.; Christodoulides, Demetrios N.; Wise, Frank W.

    2017-10-01

    A laser is based on the electromagnetic modes of its resonator, which provides the feedback required for oscillation. Enormous progress has been made toward controlling the interactions of longitudinal modes in lasers with a single transverse mode. For example, the field of ultrafast science has been built on lasers that lock many longitudinal modes together to form ultrashort light pulses. However, coherent superposition of longitudinal and transverse modes in a laser has received little attention. We show that modal and chromatic dispersions in fiber lasers can be counteracted by strong spatial and spectral filtering. This allows locking of multiple transverse and longitudinal modes to create ultrashort pulses with a variety of spatiotemporal profiles. Multimode fiber lasers thus open new directions in studies of nonlinear wave propagation and capabilities for applications.

  3. Design and Validation of an Infrared Badal Optometer for Laser Speckle (IBOLS)

    PubMed Central

    Teel, Danielle F. W.; Copland, R. James; Jacobs, Robert J.; Wells, Thad; Neal, Daniel R.; Thibos, Larry N.

    2009-01-01

    Purpose To validate the design of an infrared wavefront aberrometer with a Badal optometer employing the principle of laser speckle generated by a spinning disk and infrared light. The instrument was designed for subjective meridional refraction in infrared light by human patients. Methods Validation employed a model eye with known refractive error determined with an objective infrared wavefront aberrometer. The model eye was used to produce a speckle pattern on an artificial retina with controlled amounts of ametropia introduced with auxiliary ophthalmic lenses. A human observer performed the psychophysical task of observing the speckle pattern (with the aid of a video camera sensitive to infrared radiation) formed on the artificial retina. Refraction was performed by adjusting the vergence of incident light with the Badal optometer to nullify the motion of laser speckle. Validation of the method was performed for different levels of spherical ametropia and for various configurations of an astigmatic model eye. Results Subjective measurements of meridional refractive error over the range −4D to + 4D agreed with astigmatic refractive errors predicted by the power of the model eye in the meridian of motion of the spinning disk. Conclusions Use of a Badal optometer to control laser speckle is a valid method for determining subjective refractive error at infrared wavelengths. Such an instrument will be useful for comparing objective measures of refractive error obtained for the human eye with autorefractors and wavefront aberrometers that employ infrared radiation. PMID:18772719

  4. Monolithically Integrated Mid-Infrared Quantum Cascade Laser and Detector

    PubMed Central

    Schwarz, Benedikt; Reininger, Peter; Detz, Hermann; Zederbauer, Tobias; Andrews, Aaron Maxwell; Schrenk, Werner; Strasser, Gottfried

    2013-01-01

    We demonstrate the monolithic integration of a mid-infrared laser and detector utilizing a bi-functional quantum cascade active region. When biased, this active region provides optical gain, while it can be used as a detector at zero bias. With our novel approach we can measure the light intensity of the laser on the same chip without the need of external lenses or detectors. Based on a bound-to-continuum design, the bi-functional active region has an inherent broad electro-luminescence spectrum of 200 cm−1, which indicate sits use for single mode laser arrays. We have measured a peak signal of 191.5 mV at theon-chip detector, without any amplification. The room-temperature pulsed emission with an averaged power consumption of 4 mW and the high-speed detection makes these devices ideal for low-power sensors. The combination of the on-chip detection functionality, the broad emission spectrum and the low average power consumption indicates the potential of our bi-functional quantum cascade structures to build a mid-infrared lab-on-a-chip based on quantum cascade laser technology. PMID:23389348

  5. Infrared Mass Spectrometry for Environmental and Biomedical Applications

    NASA Astrophysics Data System (ADS)

    Baltz-Knorr, M. L.; Papantonakis, M. R.; Ermer Haglund, D. R., Jr.

    2000-11-01

    Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) using a tunable, ultrashort pulse, mid-infrared free electron laser (FEL) has many applications for both environmental and biomedical research. Environmentally, the characterization of stored nuclear materials has been an important area of research. We are developing a method to determine nuclear tank waste constituents using MALDI MS. This includes desorption and ionization of small organic molecules from sodium nitrate solids and slurries (similar to the salt cake found in some tanks) and also from traditional MALDI matrices. Important aspects of the technique are that it does not produce a secondary waste stream and it is potentially field-deployable using solid-state lasers. Biomedically, the ability to do proteomics is being enhanced by the sensitivity and mass accuracy provided by MALDI MS. We are using MALDI MS to identify proteins embedded in liquid matrix materials, which provide a more natural environment for the biomolecules. We are also working on coupling MALDI MS to traditional protein identification and sequencing techniques for rapid analysis of large numbers of proteins. Research supported by the Office of Naval Research and the U.S. Department of Energy

  6. Continuous glucose determination using fiber-based tunable mid-infrared laser spectroscopy

    NASA Astrophysics Data System (ADS)

    Yu, Songlin; Li, Dachao; Chong, Hao; Sun, Changyue; Xu, Kexin

    2014-04-01

    Wavelength-tunable laser spectroscopy in combination with a small-sized fiber-optic attenuated total reflection (ATR) sensor (fiber-based evanescent field analysis, FEFA) is reported for the continuous measurement of the glucose level. We propose a method of controlling and stabilizing the wavelength and power of laser emission and present a newly developed mid-infrared wavelength-tunable laser with a broad emission spectrum band of 9.19-9.77 μm (1024-1088 cm-1). The novel small-sized flow-through fiber-optic ATR sensor with long optical sensing length was used for glucose level determination. The experimental results indicate that the noise-equivalent concentration of this laser measurement system is as low as 3.8 mg/dL, which is among the most precise glucose measurements using mid-infrared spectroscopy. The sensitivity, which is three times that of conventional Fourier transform infrared spectrometer, was acquired because of the higher laser power and higher spectral resolution. The best prediction of the glucose concentration in phosphate buffered saline solution was achieved using the five-variable partial least-squares model, yielding a root-mean-square error of prediction as small as 3.5 mg/dL. The high sensitivity, multiple tunable wavelengths and small fiber-based sensor with long optical sensing length make glucose determination possible in blood or interstitial fluid in vivo.

  7. Fiber based infrared lasers and their applications in medicine, spectroscopy and metrology

    NASA Astrophysics Data System (ADS)

    Alexander, Vinay Varkey

    In my thesis, I have demonstrated the development of fiber based infrared lasers and devices for applications in medicine, spectroscopy and metrology. One of the key accomplishments presented in this thesis for medical applications is the demonstration of a focused infrared laser to perform renal denervation both in vivo and in vitro. Hypertension is a significant health hazard in the US and throughout the world, and the laser based renal denervation procedure may be a potential treatment for resistant hypertension. Compared to current treatment modalities, lasers may be able to perform treatments with lesser collateral tissue damage and quicker treatment times helping to reduce patient discomfort and pain. An additional medical application demonstrated in this thesis is the use of infrared fiber lasers to damage sebaceous glands in human skin as a potential treatment for acne. Another significant work presented in this thesis is a field trial performed at the Wright Patterson Air Force Base using a Short Wave Infrared (SWIR) Supercontinuum (SC) laser as an active illumination source for long distance reflectance measurements. In this case, an SC laser developed as part of this thesis is kept on a 12 story tower and propagated through the atmosphere to a target kept 1.6 km away and used to perform spectroscopy measurements. In the future this technology may permit 24/7 surveillance based on looking for the spectral signatures of materials. Beyond applications in defense, this technology may have far reaching commercial applications as well, including areas such as oil and natural resources exploration. Beyond these major contributions to the state-of-the-art, this thesis also describes other significant studies such as power scalability of SWIR SC sources and non-invasive measurement of surface roughness.

  8. Nonresonant interaction of ultrashort electromagnetic pulses with multilevel quantum systems

    NASA Technical Reports Server (NTRS)

    Belenov, E.; Isakov, V.; Nazarkin, A.

    1994-01-01

    Some features of the excitation of multilevel quantum systems under the action of electromagnetic pulses which are shorter than the inverse frequency of interlevel transitions are considered. It is shown that the interaction is characterized by a specific type of selectivity which is not connected with the resonant absorption of radiation. The simplest three-level model displays the inverse population of upper levels. The effect of an ultrashort laser pulse on a multilevel molecule was regarded as an instant reception of the oscillation velocity by the oscillator and this approach showed an effective excitation and dissociation of the molecule. The estimations testify to the fact that these effects can be observed using modern femtosecond lasers.

  9. Mid-Infrared Photonic Devices Fabricated by Ultrafast Laser Inscription

    DTIC Science & Technology

    2016-07-01

    active and passive photonic devices in single crystal, ceramic and glass substrates. This range of devices span applications such as: astrophysics [16...waveguide has been published this year in Applied Physics Letters. Reference: Macdonald, J.R., et al., Compact mid-infrared Cr:ZnSe channel...waveguide laser. Applied Physics Letters, 2013. 102(16): p. 161110. High efficiency circular cladding WG laser The initial demonstration of square double

  10. Use of near infrared femtosecond lasers as sub-micron radiation microbeam for cell DNA damage and repair studies.

    PubMed

    Botchway, S W; Reynolds, P; Parker, A W; O'Neill, P

    2010-01-01

    Laser induced radiation microbeam technology for radiobiology research is undergoing rapid growth because of the increased availability and ease of use of femtosecond laser sources. The main processes involved are multiphoton absorption and/or plasma formation. The high peak powers these lasers generate make them ideal tools for depositing sub-micrometer size radiant energy within a region of a living cell nucleus to activate ionising and/or photochemically driven processes. The technique allows questions relating to the effects of low doses of radiation, the propagation and treatment of deoxyribonucleic acid (DNA) damage and repair in individual live cells as well as non-targeted cell to cell effects to be addressed. This mini-review focuses on the use of near infrared (NIR) ca. 800nm radiation to induce damage that is radically different from the early and subsequent ultraviolet microbeam techniques. Ultrafast pulsed NIR instrumentation has many benefits including the ability to eliminate issues of unspecific UV absorption by the many materials prevalent within cells. The multiphoton interaction volume also permits energy deposition beyond the diffraction limit. Work has established that the fundamental process of the damage induced by the ultrashort laser pulses is different to those induced from continuous wave light sources. Pioneering work has demonstrated that NIR laser microbeam radiation can mimic ionising radiation via multiphoton absorption within the 3D femtolitre volume of the highly focused Gaussian beam. This light-matter interaction phenomenon provides a novel optical microbeam probe for mimicking both complex ionising and UV radiation-type cell damage including double strand breaks (DSBs) and base damage. A further advantage of the pulsed laser technique is that it provides further scope for time-resolved experiments. Recently the NIR laser microbeam technique has been used to investigate the recruitment of repair proteins to the sub

  11. Dental enamel irradiated with infrared diode laser and photoabsorbing cream: Part 1 -- FT-Raman Study.

    PubMed

    de Sant'anna, Giselle Rodrigues; dos Santos, Edson Aparecido Pereira; Soares, Luís Eduardo Silva; do Espírito Santo, Ana Maria; Martin, Airton Abrahão; Duarte, Danilo Antônio; Pacheco-Soares, Cristina; Brugnera, Aldo

    2009-06-01

    The aim of this FT-Raman study was to investigate laser-induced compositional changes in enamel after therapy with a low-level infrared diode laser and a photoabsorbing cream, in order to intensify the superficial light absorption before and after cariogenic challenge. Dental caries remains the most prevalent disease during childhood and adolescence. Preventive modalities include the use of fluoride, reduction of dietary cariogenic refined carbohydrates, plaque removal and oral hygiene techniques, and antimicrobial prescriptions. A relatively simple and noninvasive caries preventive regimen is treating tooth enamel with laser irradiation, either alone or in combination with topical fluoride treatment, resulting in reduced enamel solubility and dissolution rates. Due to their high cost, high-powered lasers are still not widely employed in private practice in developing countries. Thus, low-power red and near-infrared lasers appear to be an appealing alternative. Twenty-four extracted or exfoliated caries-free deciduous molars were divided into six groups: control group (no treatment; n = 8); infrared laser treatment (L; n = 8) (810 nm at 100 mW/cm(2) for 90 sec); infrared diode laser irradiation (810 nm at 100 mW/cm(2) for 90 sec) and photoabsorbing cream (IVL; n = 8); photoabsorbing cream alone (IV; n = 8); infrared diode laser irradiation (810 nm at 100 mW/cm(2) for 90 sec) and fluorinated photoabsorbing agent (IVLF; n = 8); and fluorinated photoabsorbing agent alone (IVF; n = 8). Samples were analyzed using FT-Raman spectroscopy before and after pH cycling cariogenic challenge. There was a significant laser-induced reduction and possible modification of the organic matrix content in enamel treated with the low-level diode laser (the L, IVL, and IVFL groups). The FT-Raman technique may be suitable for detecting compositional and structural changes occurring in mineral phases and organic phases of lased enamel under cariogenic challenge.

  12. Real-time quantum cascade laser-based infrared microspectroscopy in-vivo

    NASA Astrophysics Data System (ADS)

    Kröger-Lui, N.; Haase, K.; Pucci, A.; Schönhals, A.; Petrich, W.

    2016-03-01

    Infrared microscopy can be performed to observe dynamic processes on a microscopic scale. Fourier-transform infrared spectroscopy-based microscopes are bound to limitations regarding time resolution, which hampers their potential for imaging fast moving systems. In this manuscript we present a quantum cascade laser-based infrared microscope which overcomes these limitations and readily achieves standard video frame rates. The capabilities of our setup are demonstrated by observing dynamical processes at their specific time scales: fermentation, slow moving Amoeba Proteus and fast moving Caenorhabditis elegans. Mid-infrared sampling rates between 30 min and 20 ms are demonstrated.

  13. Ultrashort pulse laser micro-welding of cyclo-olefin copolymers

    NASA Astrophysics Data System (ADS)

    Roth, Gian-Luca; Rung, Stefan; Hellmann, Ralf

    2017-06-01

    We report on the joining of transparent thermoplastic polymers using infrared femtosecond laser pulses. Due to nonlinear absorption, the developed micro-welding process for cyclo-olefin copolymers does not require any intermediate absorbing layers or any surface pre-processing of the welding partners. In view of an optimized and stable micro-welding process, the influence of the welding speed and focal position on both, the quality and shear force strength are investigated. We highlight that welding seam widths of down to 65 μm are feasible for welding speeds of up to 75 mm/s. However, a variation of the welding speed affects the required focal position for a successful joining process. The shear force strength of the welding seam is determined to 37 MPa, which corresponds to 64% of the shear strength of the bulk material and is not affected by the welding speed.

  14. Broadly tunable terahertz generation in mid-infrared quantum cascade lasers.

    PubMed

    Vijayraghavan, Karun; Jiang, Yifan; Jang, Min; Jiang, Aiting; Choutagunta, Karthik; Vizbaras, Augustinas; Demmerle, Frederic; Boehm, Gerhard; Amann, Markus C; Belkin, Mikhail A

    2013-01-01

    Room temperature, broadly tunable, electrically pumped semiconductor sources in the terahertz spectral range, similar in operation simplicity to diode lasers, are highly desired for applications. An emerging technology in this area are sources based on intracavity difference-frequency generation in dual-wavelength mid-infrared quantum cascade lasers. Here we report terahertz quantum cascade laser sources based on an optimized non-collinear Cherenkov difference-frequency generation scheme that demonstrates dramatic improvements in performance. Devices emitting at 4 THz display a mid-infrared-to-terahertz conversion efficiency in excess of 0.6 mW W(-2) and provide nearly 0.12 mW of peak power output. Devices emitting at 2 and 3 THz fabricated on the same chip display 0.09 and 0.4 mW W(-2) conversion efficiencies at room temperature, respectively. High terahertz-generation efficiency and relaxed phase-matching conditions offered by the Cherenkov scheme allowed us to demonstrate, for the first time, an external-cavity terahertz quantum cascade laser source tunable between 1.70 and 5.25 THz.

  15. Direct femtosecond laser writing of buried infrared waveguides in chalcogenide glasses

    NASA Astrophysics Data System (ADS)

    Le Coq, D.; Bychkov, E.; Masselin, P.

    2016-02-01

    Direct laser writing technique is now widely used in particular in glass, to produce both passive and active photonic devices. This technique offers a real scientific opportunity to generate three-dimensional optical components and since chalcogenide glasses possess transparency properties from the visible up to mid-infrared range, they are of great interest. Moreover, they also have high optical non-linearity and high photo-sensitivity that make easy the inscription of refractive index modification. The understanding of the fundamental and physical processes induced by the laser pulses is the key to well-control the laser writing and consequently to realize integrated photonic devices. In this paper, we will focus on two different ways allowing infrared buried waveguide to be obtained. The first part will be devoted to a very original writing process based on a helical translation of the sample through the laser beam. In the second part, we will report on another original method based on both a filamentation phenomenon and a point by point technique. Finally, we will demonstrate that these two writing techniques are suitable for the design of single mode waveguide for wavelength ranging from the visible up to the infrared but also to fabricate optical components.

  16. Near-Infrared Laser Adjuvant for Influenza Vaccine

    PubMed Central

    Kashiwagi, Satoshi; Yuan, Jianping; Forbes, Benjamin; Hibert, Mathew L.; Lee, Eugene L. Q.; Whicher, Laura; Goudie, Calum; Yang, Yuan; Chen, Tao; Edelblute, Beth; Collette, Brian; Edington, Laurel; Trussler, James; Nezivar, Jean; Leblanc, Pierre; Bronson, Roderick; Tsukada, Kosuke; Suematsu, Makoto; Dover, Jeffrey; Brauns, Timothy; Gelfand, Jeffrey; Poznansky, Mark C.

    2013-01-01

    Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or biological agents, significantly increases immune responses to intradermal influenza vaccination without augmenting IgE. The NIR laser-adjuvanted vaccine confers increased protection in a murine influenza lethal challenge model as compared to unadjuvanted vaccine. We show that NIR laser treatment induces the expression of specific chemokines in the skin resulting in recruitment and activation of dendritic cells and is safe to use in both mice and humans. The NIR laser adjuvant technology provides a novel, safe, low-cost, simple-to-use, potentially broadly applicable and clinically feasible approach to enhancing vaccine efficacy as an alternative to chemical and biological adjuvants. PMID:24349390

  17. Femtosecond measurements of near-infrared pulse induced mid-infrared transmission modulation of quantum cascade lasers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cai, Hong; Liu, Sheng; Center for Advanced Studied in Photonics Research

    2014-05-26

    We temporally resolved the ultrafast mid-infrared transmission modulation of quantum cascade lasers (QCLs) using a near-infrared pump/mid-infrared probe technique at room temperature. Two different femtosecond wavelength pumps were used with photon energy above and below the quantum well (QW) bandgap. The shorter wavelength pump modulates the mid-infrared probe transmission through interband transition assisted mechanisms, resulting in a high transmission modulation depth and several nanoseconds recovery lifetime. In contrast, pumping with a photon energy below the QW bandgap induces a smaller transmission modulation depth but much faster (several picoseconds) recovery lifetime, attributed to intersubband transition assisted mechanisms. The latter ultrafast modulationmore » (>60 GHz) could provide a potential way to realize fast QCL based free space optical communication.« less

  18. Self-cleaning effect in high quality percussion ablating of cooling hole by picosecond ultra-short pulse laser

    NASA Astrophysics Data System (ADS)

    Zhao, Wanqin; Yu, Zhishui

    2018-06-01

    Comparing with the trepanning technology, cooling hole could be processed based on the percussion drilling with higher processing efficiency. However, it is widely believed that the ablating precision of hole is lower for percussion drilling than for trepanning, wherein, the melting spatter materials around the hole surface and the recast layer inside the hole are the two main issues for reducing the ablating precision of hole, especially for the recast layer, it can't be eliminated completely even through the trepanning technology. In this paper, the self-cleaning effect which is a particular property just for percussion ablating of holes has been presented in detail. In addition, the reasons inducing the self-cleaning effect have been discussed. At last, based on the self-cleaning effect of percussion drilling, high quality cooling hole without the melting spatter materials around the hole surface and recast layer inside the hole could be ablated in nickel-based superalloy by picosecond ultra-short pulse laser.

  19. PHOTONICS AND NANOTECHNOLOGY Laser nanostructuring of materials surfaces

    NASA Astrophysics Data System (ADS)

    Zavestovskaya, I. N.

    2010-12-01

    This paper reviews results of experimental and theoretical studies of surface micro- and nanostructuring of metals and other materials irradiated directly by short and ultrashort laser pulses. Special attention is paid to direct laser action involving melting of the material (with or without ablation), followed by ultrarapid surface solidification, which is an effective approach to producing surface nanostructures. Theoretical analysis of recrystallisation kinetics after irradiation by ultrashort laser pulses makes it possible to determine the volume fraction of crystallised phase and the average size of forming crystalline structures as functions of laser treatment regime and thermodynamic properties of the material. The present results can be used to optimise pulsed laser treatment regime in order to ensure control nanostructuring of metal surfaces.

  20. Interference-Free and Interference-Dominated Photoionization: Synthesis of Ultrashort and Coherent Single-Electron Wave Packets

    NASA Astrophysics Data System (ADS)

    Cajiao Vélez, F.; Kamiński, J. Z.; Krajewska, K.

    2018-04-01

    Ionization of hydrogen-like ions driven by intense, short, and circularly-polarized laser pulses is considered under the scope of the relativistic strong-field approximation. We show that the energy spectra of photoelectrons can exhibit two types of structures, i.e., interference-dominated or interference-free ones. These structures are analyzed in connection to the time-dependent ponderomotive energy of electrons in the laser field. A possibility of synthesis of ultrashort single-electron pulses from those structures is also investigated.

  1. Dual sub-picosecond and sub-nanosecond laser system

    NASA Astrophysics Data System (ADS)

    Xie, Xinglong; Liu, Fengqiao; Yang, Jingxin; Yang, Xin; Li, Meirong; Xue, Zhiling; Gao, Qi; Guan, Fuyi; Zhang, Weiqing; Huang, Guanlong; Zhuang, Yifei; Han, Aimei; Lin, Zunqi

    2003-11-01

    A high power laser system delivering a 20-TW, 0.5 - 0.8 ps ultra-short laser pulse and a 20-J, 500-ps long pulse simultaneously in one shot is completed. This two-beam laser operates at the wavelength of 1053 nm and uses Nd doped glass as the gain media of the main amplification chain. The chirped-pulse amplification (CPA) technology is used to compress the stretched laser pulse. After compression, the ultrashort laser pulse is measured: energy above 16.0 J, S/N contrast ratio ~ 10^(5) : 1, filling factor ~>52.7%. Another long pulse beam is a non-compressed chirped laser pulse, which is measured: energy ~ 20 J, pulse duration 500 ps. The two beams are directed onto the target surface at an angle of 15°.

  2. A new efficient far-infrared optically pumped laser Gas - CH3(O-18)(H)

    NASA Astrophysics Data System (ADS)

    Ioli, N.; Moretti, A.; Pereira, D.; Strumia, F.; Garelli, G.

    1989-04-01

    The (C-12)(H3)(O-18)(H) molecule has been investigated for new far-infrared laser lines by optically pumping it with a CW waveguide CO2 laser. The larger tunability (318 MHz) with respect to a conventional CO2 laser permits the pumping of many (C-12)(H3)(O-18)(H) lines. As a consequence 100 new laser lines have been discovered, ranging from 34.6 to 653.2-microns in wavelength. The infrared spectrum of (C-12)(H3)(O-18)(H) has been observed and all the fundamental vibration energies measured.

  3. Mid-infrared absorption spectroscopy using quantum cascade lasers

    NASA Astrophysics Data System (ADS)

    Haibach, Fred; Erlich, Adam; Deutsch, Erik

    2011-06-01

    Block Engineering has developed an absorption spectroscopy system based on widely tunable Quantum Cascade Lasers (QCL). The QCL spectrometer rapidly cycles through a user-selected range in the mid-infrared spectrum, between 6 to 12 μm (1667 to 833 cm-1), to detect and identify substances on surfaces based on their absorption characteristics from a standoff distance of up to 2 feet with an eye-safe laser. It can also analyze vapors and liquids in a single device. For military applications, the QCL spectrometer has demonstrated trace explosive, chemical warfare agent (CWA), and toxic industrial chemical (TIC) detection and analysis. The QCL's higher power density enables measurements from diffuse and highly absorbing materials and substrates. Other advantages over Fourier Transform Infrared (FTIR) spectroscopy include portability, ruggedness, rapid analysis, and the ability to function from a distance through free space or a fiber optic probe. This paper will discuss the basic technology behind the system and the empirical data on various safety and security applications.

  4. Efficient, High-Power Mid-Infrared Laser for National Securityand Scientific Applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kiani, Leily S.

    The LLNL fiber laser group developed a unique short-wave-infrared, high-pulse energy, highaverage- power fiber based laser. This unique laser source has been used in combination with a nonlinear frequency converter to generate wavelengths, useful for remote sensing and other applications in the mid-wave infrared (MWIR). Sources with high average power and high efficiency in this MWIR wavelength region are not yet available with the size, weight, and power requirements or energy efficiency necessary for future deployment. The LLNL developed Fiber Laser Pulsed Source (FiLPS) design was adapted to Erbium doped silica fibers for 1.55 μm pumping of Cadmium Silicon Phosphidemore » (CSP). We have demonstrated, for the first time optical parametric amplification of 2.4 μm light via difference frequency generation using CSP with an Erbium doped fiber source. In addition, for efficiency comparison purposes, we also demonstrated direct optical parametric generation (OPG) as well as optical parametric oscillation (OPO).« less

  5. Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy

    PubMed Central

    Sato, Kazuhide; Watanabe, Rira; Hanaoka, Hirofumi; Nakajima, Takahito; Choyke, Peter L.; Kobayashi, Hisataka

    2016-01-01

    Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light. Herein we compare two NIR-light sources; light emitting diodes (LEDs) and Lasers, for their effectiveness in NIR-PIT. A photosensitizer, IRDye-700DX, conjugated to panitumumab (pan-IR700), was incubated with EGFR-expressing A431 and MDA-MB-468-luc cells. NIR-light was provided by LEDs or Lasers at the same light dose. Laser-light produced more cytotoxicity and greater reductions in IR700-fluorescence intensity than LED-light. Laser-light also produced more cytotoxicity in vivo in both cell lines. Assessment of super-enhanced permeability and retention (SUPR) effects were stronger with Laser than LED. These results suggest that Laser-light produced significantly more cytotoxic effects compared to LEDs. Although LED is less expensive, Laser-light produces superior results in NIR-PIT. PMID:26885688

  6. Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy.

    PubMed

    Sato, Kazuhide; Watanabe, Rira; Hanaoka, Hirofumi; Nakajima, Takahito; Choyke, Peter L; Kobayashi, Hisataka

    2016-03-22

    Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light. Herein we compare two NIR-light sources; light emitting diodes (LEDs) and Lasers, for their effectiveness in NIR-PIT. A photosensitizer, IRDye-700DX, conjugated to panitumumab (pan-IR700), was incubated with EGFR-expressing A431 and MDA-MB-468-luc cells. NIR-light was provided by LEDs or Lasers at the same light dose. Laser-light produced more cytotoxicity and greater reductions in IR700-fluorescence intensity than LED-light. Laser-light also produced more cytotoxicity in vivo in both cell lines. Assessment of super-enhanced permeability and retention (SUPR) effects were stronger with Laser than LED. These results suggest that Laser-light produced significantly more cytotoxic effects compared to LEDs. Although LED is less expensive, Laser-light produces superior results in NIR-PIT.

  7. Ultrashort-pulse lasers treating the crystalline lens: will they cause vision-threatening cataract? (An American Ophthalmological Society thesis).

    PubMed

    Krueger, Ronald R; Uy, Harvey; McDonald, Jared; Edwards, Keith

    2012-12-01

    To demonstrate that ultrashort-pulse laser treatment in the crystalline lens does not form a focal, progressive, or vision-threatening cataract. An Nd:vanadate picosecond laser (10 ps) with prototype delivery system was used. Primates: 11 rhesus monkey eyes were prospectively treated at the University of Wisconsin (energy 25-45 μJ/pulse and 2.0-11.3M pulses per lens). Analysis of lens clarity and fundus imaging was assessed postoperatively for up to 4½ years (5 eyes). Humans: 80 presbyopic patients were prospectively treated in one eye at the Asian Eye Institute in the Philippines (energy 10 μJ/pulse and 0.45-1.45M pulses per lens). Analysis of lens clarity, best-corrected visual acuity, and subjective symptoms was performed at 1 month, prior to elective lens extraction. Bubbles were immediately seen, with resolution within the first 24 to 48 hours. Afterwards, the laser pattern could be seen with faint, noncoalescing, pinpoint micro-opacities in both primate and human eyes. In primates, long-term follow-up at 4½ years showed no focal or progressive cataract, except in 2 eyes with preexisting cataract. In humans, <25% of patients with central sparing (0.75 and 1.0 mm radius) lost 2 or more lines of best spectacle-corrected visual acuity at 1 month, and >70% reported acceptable or better distance vision and no or mild symptoms. Meanwhile, >70% without sparing (0 and 0.5 mm radius) lost 2 or more lines, and most reported poor or severe vision and symptoms. Focal, progressive, and vision-threatening cataracts can be avoided by lowering the laser energy, avoiding prior cataract, and sparing the center of the lens.

  8. Dental enamel irradiated with infrared diode laser and photo-absorbing cream: part 2--EDX study.

    PubMed

    de Sant'Anna, Giselle Rodrigues; dos Santos, Edson Aparecido Pereira; Soares, Luís Eduardo Silva; do Espírito Santo, Ana Maria; Martin, Airton Abrahão; Duarte, Danilo Antônio; Pacheco-Soares, Cristina; Brugnera, Aldo

    2009-10-01

    The effects of laser-induced compositional changes on the enamel were investigated by energy-dispersive X-ray fluorescence spectrometry (micro-EDX). After cariogenic challenge, we administered treatment of low-level infrared diode laser and a photo-absorbing cream (used to intensify the superficial light absorption). Dental caries is considered the most prevalent oral disease. A simple and noninvasive caries preventive regimen is treating tooth enamel with a laser, either alone or in combination with fluoride, which reduces enamel solubility and dissolution rates. High power lasers are still not widely used in private practice. Low-power near-infrared lasers may be an alternative approach. Energy-dispersive micro-EDX is a versatile and nondestructive spectroscopic technique that allows for a qualitative and quantitative elemental analysis of inorganic enamel components, such as calcium and phosphorus. Twenty-four extracted or exfoliated caries-free deciduous molars were divided into six groups: 1) control group (CTR-no treatment); 2) infrared laser treatment (L) (lambda = 810 nm, 100 mW/cm(2), 90 sec, 4.47 J/cm(2), 9 J); 3) infrared laser irradiation and photo-absorbing agent (CL); 4) photo-absorbing agent alone (C); 5) infrared laser irradiation and fluoridated photo-absorbing agent (FCL); and 6) fluoridated photo-absorbing agent alone (FC). Samples were analyzed using micro-EDX after two sets of treatments and pH cycling cariogenic challenges. The CL group showed statistically significant increases in calcium and phosphorus (wt%) compared with the CTR group. The Ca/P ratio was similar in the FCL and CTR groups. There was a significant laser-induced reduction compared with the CTR group, and there was a possible modification of the organic balance content in enamel treated with laser and cream. micro-EDX may be able to detect compositional changes in mineral phases of lased enamel under cariogenic challenge. Our results suggest that with a combined laser and photo

  9. Near-infrared induced optical quenching effects on mid-infrared quantum cascade lasers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guo, Dingkai, E-mail: dingk1@umbc.edu; Talukder, Muhammad Anisuzzaman; Chen, Xing

    In space communications, atmospheric absorption and Rayleigh scattering are the dominant channel impairments. Transmission using mid-infrared (MIR) wavelengths offers the benefits of lower loss and less scintillation effects. In this work, we report the telecom wavelengths (1.55 μm and 1.3 μm) induced optical quenching effects on MIR quantum cascade lasers (QCLs), when QCLs are operated well above their thresholds. The QCL output power can be near 100% quenched using 20 mW of near-infrared (NIR) power, and the quenching effect depends on the input NIR intensity as well as wavelength. Time resolved measurement was conducted to explore the quenching mechanism. The measured recovery timemore » is around 14 ns, which indicates that NIR generated electron-hole pairs may play a key role in the quenching process. The photocarrier created local field and band bending can effectively deteriorate the dipole transition matrix element and quench the QCL. As a result, MIR QCLs can be used as an optical modulator and switch controlled by NIR lasers. They can also be used as “converters” to convert telecom optical signals into MIR optical signals.« less

  10. Near-infrared laser irradiation improves the development of mouse pre-implantation embryos

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yokoo, Masaki; Mori, Miho

    The aim of the present study was to assess the effects of near-infrared laser irradiation on the in vitro development of mouse embryos. Female ICR mice were superovulated with pregnant mare serum gonadotropin and human chorionic gonadotropin (hCG), and mated with male mice. Two-cell stage embryos were collected 40 h after administering hCG and cultured in M16 medium. Two-cell embryos (0 h after culture), 8-cell embryos (approx. 30 h after culture), morula (approx. 48 h after culture), and blastocysts (approx. 73 h after culture) were irradiated at 904 nm for 60 s. These embryos were cultured in a time-lapse monitoring system and the timing ofmore » blastocyst hatching was evaluated. Some of the irradiated blastocysts were transferred to the uterine horns of pseudopregnant recipients immediately after irradiation. Pregnancy rates, and offspring growth and fertility, were evaluated. Near-infrared laser irradiation increased the speed of in vitro mouse embryo development. In irradiated blastocysts, hatching was faster than in control (non-irradiated) blastocysts (18.4 vs. 28.2 h, P < 0.05). When 195 irradiated blastocysts were transferred to 18 pseudopregnant mice, all became pregnant and 92 (47.2%) normal-looking pups were born alive. When 182 control blastocysts were transferred to 17 pseudopregnant mice, 14 (82.4%) became pregnant and 54 (29.7%) normal-looking pups were born alive. The growth trajectories (up to 5 weeks) of offspring from irradiated blastocysts were similar to those from control blastocysts. Second generation offspring from transplanted animals were all fertile. These results indicate that near-infrared laser irradiation improves the quality of mouse embryo development in vitro, and increases the live birth rate without affecting the normality of the offspring. Thus, the near-infrared laser method may enhance the quality of embryos and contribute to improvements in reproductive technologies in mammals. - Highlights: • Irradiation of

  11. First-principles simulation of the optical response of bulk and thin-film α-quartz irradiated with an ultrashort intense laser pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Kyung-Min; Min Kim, Chul; Moon Jeong, Tae, E-mail: jeongtm@gist.ac.kr

    A computational method based on a first-principles multiscale simulation has been used for calculating the optical response and the ablation threshold of an optical material irradiated with an ultrashort intense laser pulse. The method employs Maxwell's equations to describe laser pulse propagation and time-dependent density functional theory to describe the generation of conduction band electrons in an optical medium. Optical properties, such as reflectance and absorption, were investigated for laser intensities in the range 10{sup 10} W/cm{sup 2} to 2 × 10{sup 15} W/cm{sup 2} based on the theory of generation and spatial distribution of the conduction band electrons. The method was applied tomore » investigate the changes in the optical reflectance of α-quartz bulk, half-wavelength thin-film, and quarter-wavelength thin-film and to estimate their ablation thresholds. Despite the adiabatic local density approximation used in calculating the exchange–correlation potential, the reflectance and the ablation threshold obtained from our method agree well with the previous theoretical and experimental results. The method can be applied to estimate the ablation thresholds for optical materials, in general. The ablation threshold data can be used to design ultra-broadband high-damage-threshold coating structures.« less

  12. Ultra-short ion and neutron pulse production

    DOEpatents

    Leung, Ka-Ngo; Barletta, William A.; Kwan, Joe W.

    2006-01-10

    An ion source has an extraction system configured to produce ultra-short ion pulses, i.e. pulses with pulse width of about 1 .mu.s or less, and a neutron source based on the ion source produces correspondingly ultra-short neutron pulses. To form a neutron source, a neutron generating target is positioned to receive an accelerated extracted ion beam from the ion source. To produce the ultra-short ion or neutron pulses, the apertures in the extraction system of the ion source are suitably sized to prevent ion leakage, the electrodes are suitably spaced, and the extraction voltage is controlled. The ion beam current leaving the source is regulated by applying ultra-short voltage pulses of a suitable voltage on the extraction electrode.

  13. Ultrashort pulse laser deposition of thin films

    DOEpatents

    Perry, Michael D.; Banks, Paul S.; Stuart, Brent C.

    2002-01-01

    Short pulse PLD is a viable technique of producing high quality films with properties very close to that of crystalline diamond. The plasma generated using femtosecond lasers is composed of single atom ions with no clusters producing films with high Sp.sup.3 /Sp.sup.2 ratios. Using a high average power femtosecond laser system, the present invention dramatically increases deposition rates to up to 25 .mu.m/hr (which exceeds many CVD processes) while growing particulate-free films. In the present invention, deposition rates is a function of laser wavelength, laser fluence, laser spot size, and target/substrate separation. The relevant laser parameters are shown to ensure particulate-free growth, and characterizations of the films grown are made using several diagnostic techniques including electron energy loss spectroscopy (EELS) and Raman spectroscopy.

  14. Standard measurement procedures for the characterization of fs-laser optical components

    NASA Astrophysics Data System (ADS)

    Starke, Kai; Ristau, Detlev; Welling, Herbert

    2003-05-01

    Ultra-short pulse laser systems are considered as promising tools in the fields of precise micro-machining and medicine applications. In the course of the development of reliable table top laser systems, a rapid growth of ultra-short pulse applications could be observed during the recent years. The key for improving the performance of high power laser systems is the quality of the optical components concerning spectral characteristics, optical losses and the power handling capability. In the field of ultra-short pulses, standard measurement procedures in quality management have to be validated in respect to effects induced by the extremely high peak power densities. The present work, which is embedded in the EUREKA-project CHOCLAB II, is predominantly concentrated on measuring the multiple-pulse LIDT (ISO 11254-2) in the fs-regime. A measurement facility based on a Ti:Sapphire-CPA system was developed to investigate the damage behavior of optical components. The set-up was supplied with an improved pulse energy detector discriminating the influence of pulse-to-pulse energy fluctuations on the incidence of damage. Aditionally, a laser-calorimetric measurement facility determining the absorption (ISO 11551) utilizing a fs-Ti:Sapphire laser was accomplished. The investigation for different pulse durations between 130 fs and 1 ps revealed a drastic increase of absorption in titania coatings for ultra-short pulses.

  15. Far-infrared laser diagnostics on the HT-6M tokamak

    NASA Astrophysics Data System (ADS)

    Gao, X.; Lu, H. J.; Guo, Q. L.; Wan, Y. X.; Tong, X. D.

    1995-01-01

    A multichannel far-infrared (FIR) hydrogen cyanide (HCN) laser interferometer was developed to measure plasma electron density profile on the HT-6M tokamak. The structure of the seven-channel FIR laser interferometer is described. The laser source used in the interferometer was a continuous-wave glow discharge HCN laser with a cavity length of 3.4 m and power output of about 100 mW at 337 μm. The detection sensitivity was 1/15 fringe with a temporal resolution of 0.1 ms. Experimental results were measured by the seven-channel FIR HCN laser interferometer with edge Ohmic heating, a pumping limiter, and ion cyclotron resonant heating on the HT-6M tokamak are reported.

  16. Mechanisms of high-regularity periodic structuring of silicon surface by sub-MHz repetition rate ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Gnilitskyi, Iaroslav; Gruzdev, Vitaly; Bulgakova, Nadezhda M.; Mocek, Tomáš; Orazi, Leonardo

    2016-10-01

    Silicon is one of the most abundant materials which is used in many areas of modern research and technology. A variety of those applications require surface nanopatterning with minimum structure defects. However, the high-quality nanostructuring of large areas of silicon surface at industrially acceptable speed is still a challenge. Here, we report a rapid formation of highly regular laser-induced periodic surface structures (HR-LIPSS) in the regime of strong ablation by infrared femtosecond laser pulses at sub-MHz repetition rate. Parameters of the laser-surface interactions and obtained experimental results suggest an important role of electrostatically assisted bond softening in initiating the HR-LIPSS formation.

  17. Bibliography of Soviet Laser Developments, No. 18, October - December 1974

    DTIC Science & Technology

    1975-04-25

    IIV Lasers, Laser Theory , Laser Biological Effects, Laser Communications, Laser Computer Technology, Holography, Laser Chemical Effects...spectros.copy of laser materials; ultrashort pulse generation; crystal growing; theoretical aspects of advanced lasers; and general laser theory Laser...Semiconductor: Mixed Junction 5 6. Semiconductor: Heterojunction ^ 7. Semiconductor: Theory 8. Nd:Glass B. Liquid Lasers 1

  18. Laser capture microdissection: should an ultraviolet or infrared laser be used?

    PubMed

    Vandewoestyne, Mado; Goossens, Karen; Burvenich, Christian; Van Soom, Ann; Peelman, Luc; Deforce, Dieter

    2013-08-15

    Laser capture microdissection (LCM) is a well-established cell separation technique. It combines microscopy with laser beam technology and allows targeting of specific cells or tissue regions that need to be separated from others. Consequently, this biological material can be used for genome or transcriptome analyses. Appropriate methods of sample preparation, however, are crucial for the success of downstream molecular analysis. The aim of this study was to objectively compare the two main LCM systems, one based on an ultraviolet (UV) laser and the other based on an infrared (IR) laser, on different criteria ranging from user-friendliness to sample quality. The comparison was performed on two types of samples: peripheral blood mononuclear cells and blastocysts. The UV laser LCM system had several advantages over the IR laser LCM system. Not only does the UV system allow faster and more precise sample collection, but also the obtained samples-even single cell samples-can be used for DNA extraction and downstream polymerase chain reaction (PCR) applications. RNA-based applications are more challenging for both LCM systems. Although sufficient RNA can be extracted from as few as 10 cells for reverse transcription quantitative PCR (RT-qPCR) analysis, the low RNA quality should be taken into account when designing the RT-qPCR assays. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Investigation of the Comparative Effects of Red and Infrared Laser Therapy on Skeletal Muscle Repair in Diabetic Rats.

    PubMed

    Assis, Lívia; Manis, Camila; Fernandes, Kelly Rossetti; Cabral, Daniel; Magri, Angela; Veronez, Suellen; Renno, Ana Claudia Muniz

    2016-07-01

    The aim of this study was to evaluate the in vivo response of 2 different laser wavelengths (red and infrared) on skeletal muscle repair process in diabetic rats. Forty Wistar rats were randomly divided into 4 experimental groups: basal control-nondiabetic and muscle-injured animals without treatment (BC); diabetic muscle-injured without treatment (DC); diabetic muscle-injured, treated with red laser (DCR) and infrared laser (DCIR). The injured region was irradiated daily for 7 consecutive days, starting immediately after the injury using a red (660 nm) and an infrared (808 nm) laser. The histological results demonstrated in both treated groups (red and infrared wavelengths) a modulation of the inflammatory process and a better tissue organization located in the site of the injury. However, only infrared light significantly reduced the injured area and increased MyoD and myogenin protein expression. Moreover, both red and infrared light increased the expression of the proangiogenic vascular endothelial growth factor and reduced the cyclooxygenase 2 protein expression. These results suggest that low-level laser therapy was efficient in promoting skeletal muscle repair in diabetic rats. However, the effect of infrared wavelength was more pronounced by reducing the area of the injury and modulating the expression proteins related to the repair.

  20. Ultrashort-Pulse Lasers Treating the Crystalline Lens: Will They Cause Vision-Threatening Cataract? (An American Ophthalmological Society Thesis)

    PubMed Central

    Krueger, Ronald R.; Uy, Harvey; McDonald, Jared; Edwards, Keith

    2012-01-01

    Purpose: To demonstrate that ultrashort-pulse laser treatment in the crystalline lens does not form a focal, progressive, or vision-threatening cataract. Methods: An Nd:vanadate picosecond laser (10 ps) with prototype delivery system was used. Primates: 11 rhesus monkey eyes were prospectively treated at the University of Wisconsin (energy 25–45 μJ/pulse and 2.0–11.3M pulses per lens). Analysis of lens clarity and fundus imaging was assessed postoperatively for up to 4½ years (5 eyes). Humans: 80 presbyopic patients were prospectively treated in one eye at the Asian Eye Institute in the Philippines (energy 10 μJ/pulse and 0.45–1.45M pulses per lens). Analysis of lens clarity, best-corrected visual acuity, and subjective symptoms was performed at 1 month, prior to elective lens extraction. Results: Bubbles were immediately seen, with resolution within the first 24 to 48 hours. Afterwards, the laser pattern could be seen with faint, noncoalescing, pinpoint micro-opacities in both primate and human eyes. In primates, long-term follow-up at 4½ years showed no focal or progressive cataract, except in 2 eyes with preexisting cataract. In humans, <25% of patients with central sparing (0.75 and 1.0 mm radius) lost 2 or more lines of best spectacle-corrected visual acuity at 1 month, and >70% reported acceptable or better distance vision and no or mild symptoms. Meanwhile, >70% without sparing (0 and 0.5 mm radius) lost 2 or more lines, and most reported poor or severe vision and symptoms. Conclusions: Focal, progressive, and vision-threatening cataracts can be avoided by lowering the laser energy, avoiding prior cataract, and sparing the center of the lens. PMID:23818739

  1. Mid-infrared optical parametric oscillator pumped by an amplified random fiber laser

    NASA Astrophysics Data System (ADS)

    Shang, Yaping; Shen, Meili; Wang, Peng; Li, Xiao; Xu, Xiaojun

    2017-01-01

    Recently, the concept of random fiber lasers has attracted a great deal of attention for its feature to generate incoherent light without a traditional laser resonator, which is free of mode competition and insure the stationary narrow-band continuous modeless spectrum. In this Letter, we reported the first, to the best of our knowledge, optical parametric oscillator (OPO) pumped by an amplified 1070 nm random fiber laser (RFL), in order to generate stationary mid-infrared (mid-IR) laser. The experiment realized a watt-level laser output in the mid-IR range and operated relatively stable. The use of the RFL seed source allowed us to take advantage of its respective stable time-domain characteristics. The beam profile, spectrum and time-domain properties of the signal light were measured to analyze the process of frequency down-conversion process under this new pumping condition. The results suggested that the near-infrared (near-IR) signal light `inherited' good beam performances from the pump light. Those would be benefit for further develop about optical parametric process based on different pumping circumstances.

  2. Measurement of light penetration of near-infrared laser at the lumbosacral nerves in rats

    NASA Astrophysics Data System (ADS)

    Ishibashi, Naoya; Shimoyama, Hiroshi; Kawase, Yuki; Motohara, Shosaku; Okayama, Takamitsu; Niwa, Daisuke; Koyama, Jun

    2018-02-01

    Photobiomodulation or low level laser therapy (LLLT) has been utilized in various areas of medical practice including pain relief, wound healing, and inflammation treatment. Some recent animal studies have reported that near-infrared laser irradiation to the lumbosacral nerves transcutateously relieves neuropathic pain by controlling activity of lumbosacral nerves. However, transcutaneous laser penetration to the nerves has not yet been fully elucidated. Our aim is to determine the light penetration to lumbosacral nerves when near-infrared laser was irradiated transcutateously to lumbosacral nerves. We implanted photodiodes near the lumbosacral nerves of rats and connected the photodiodes to an oscilloscope through an amplifier. Near-infrared lasers (wavelengths: 808 nm and 830 nm) were irradiated through the skin at 2, 5 and 10 W pulses (Duty 10%, 5 Hz) and outputs of photodiodes were collected. After irradiation, the depth of the photodiodes and the nerves from the skin surface were determined by micro-CT device. The result showed that the fluence rate at the lumbosacral nerves was 179+/-19.2 mW/cm2 and 232+/-20.7 mW/cm2 when the 808-nm and 830-nm laser was irradiated at 10 W respectively. These findings would be beneficial for following study of photobiomodulation.

  3. Picosecond passively mode-locked mid-infrared fiber laser

    NASA Astrophysics Data System (ADS)

    Wei, C.; Zhu, X.; Norwood, R. A.; Kieu, K.; Peyghambarian, N.

    2013-02-01

    Mode-locked mid-infrared (mid-IR) fiber lasers are of increasing interest due to their many potential applications in spectroscopic sensors, infrared countermeasures, laser surgery, and high-efficiency pump sources for nonlinear wavelength convertors. Er3+-doped ZBLAN (ZrF4-BaF2-LaF3-AlF3-NaF) fiber lasers, which can emit mid-IR light at 2.65-2.9 μm through the transition from the upper energy level 4I11/2 to the lower laser level 4I13/2, have attracted much attention because of their broad emission range, high optical efficiency, and the ready availability of diode pump lasers at the two absorption peaks of Er3+ ions (975 nm and 976 nm). In recent years, significant progress on high power Er3+- doped ZBLAN fiber lasers has been achieved and over 20 watt cw output at 2.8 μm has been demonstrated; however, there has been little progress on ultrafast mid-IR ZBLAN fiber lasers to date. We report a passively mode-locked Er3+- doped ZBLAN fiber laser in which a Fe2+:ZnSe crystal was used as the intracavity saturable absorber. Fe2+:ZnSe is an ideal material for mid-IR laser pulse generation because of its large saturable absorption cross-section and small saturation energy along with the excellent opto-mechanical (damage threshold ~2 J/cm2) and physical characteristics of the crystalline ZnSe host. A 1.6 m double-clad 8 mol% Er3+-doped ZBLAN fiber was used in our experiment. The fiber core has a diameter of 15 μm and a numerical aperture (NA) of 0.1. The inner circular cladding has a diameter of 125 μm and an NA of 0.5. Both continuous-wave and Q-switched mode-locking pulses at 2.8 μm were obtained. Continuous-wave mode locking operation with a pulse duration of 19 ps and an average power of 51 mW were achieved when a collimated beam traversed the Fe2+:ZnSe crystal. When the cavity was modified to provide a focused beam at the Fe2+:ZnSe crystal, Q-switched mode-locked operation with a pulse duration of 60 ps and an average power of 4.6 mW was achieved. More powerful

  4. Mid-infrared, long wave infrared (4-12 μm) molecular emission signatures from pharmaceuticals using laser-induced breakdown spectroscopy (LIBS).

    PubMed

    Yang, Clayton S-C; Brown, Ei E; Kumi-Barimah, Eric; Hommerich, Uwe H; Jin, Feng; Trivedi, Sudhir B; Samuels, Alan C; Snyder, A Peter

    2014-01-01

    In an effort to augment the atomic emission spectra of conventional laser-induced breakdown spectroscopy (LIBS) and to provide an increase in selectivity, mid-wave to long-wave infrared (IR), LIBS studies were performed on several organic pharmaceuticals. Laser-induced breakdown spectroscopy signature molecular emissions of target organic compounds are observed for the first time in the IR fingerprint spectral region between 4-12 μm. The IR emission spectra of select organic pharmaceuticals closely correlate with their respective standard Fourier transform infrared spectra. Intact and/or fragment sample molecular species evidently survive the LIBS event. The combination of atomic emission signatures derived from conventional ultraviolet-visible-near-infrared LIBS with fingerprints of intact molecular entities determined from IR LIBS promises to be a powerful tool for chemical detection.

  5. Mid-infrared pulsed laser ultrasonic testing for carbon fiber reinforced plastics.

    PubMed

    Kusano, Masahiro; Hatano, Hideki; Watanabe, Makoto; Takekawa, Shunji; Yamawaki, Hisashi; Oguchi, Kanae; Enoki, Manabu

    2018-03-01

    Laser ultrasonic testing (LUT) can realize contactless and instantaneous non-destructive testing, but its signal-to-noise ratio must be improved in order to measure carbon fiber reinforced plastics (CFRPs). We have developed a mid-infrared (mid-IR) laser source optimal for generating ultrasonic waves in CFRPs by using a wavelength conversion device based on an optical parametric oscillator. This paper reports a comparison of the ultrasonic generation behavior between the mid-IR laser and the Nd:YAG laser. The mid-IR laser generated a significantly larger ultrasonic amplitude in CFRP laminates than a conventional Nd:YAG laser. In addition, our study revealed that the surface epoxy matrix of CFRPs plays an important role in laser ultrasonic generation. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Infrared free electron laser enhanced transdermal drug delivery

    NASA Astrophysics Data System (ADS)

    Awazu, Kunio; Uchizono, Takeyuki; Suzuki, Sachiko; Yoshikawa, Kazushi

    2005-08-01

    It is necessary to control enhancement of transdermal drug delivery with non-invasive. The present study was investigated to assess the effectivity of enhancing the drug delivery by irradiating 6-μm region mid infrared free electron laser (MIR-FEL). The enhancement of transdermal drug (lidocaine) delivery of the samples (hairless mouse skin) irradiated with lasers was examined for flux (μg/cm2/h) and total penetration amount (μg/cm2) of lidocaine by High performance Liquid Chromatography (HPLC). The flux and total amount penatration date was enhanced 200-300 fold faster than the control date by the laser irradiation. FEL irradiating had the stratum corneum, and had the less thermal damage in epidermis. The effect of 6-μm region MIR-FEL has the enhancement of transdermal drug delivery without removing the stratum corneum because it has the less thermal damage. It leads to enhancement drug delivery system with non-invasive laser treatment.

  7. Long wave infrared cavity-enhanced sensors using quantum cascade lasers

    NASA Astrophysics Data System (ADS)

    Taubman, Matthew S.; Scott, David C.; Myers, Tanya L.; Cannon, Bret D.

    2005-11-01

    Quantum cascade lasers (QCLs) are becoming well known as convenient and stable semiconductor laser sources operating in the mid- to long-wave infrared, and are able to be fabricated to operate virtually anywhere in the 3.5 to 25 micron region. This makes them an ideal choice for infrared chemical sensing, a topic of great interest at present, spanning at least three critical areas: national security, environmental monitoring and protection, and the early diagnosis of disease through breath analysis. There are many different laser-based spectroscopic chemical sensor architectures in use today, from simple direct detection through to more complex and highly sensitive systems. Many current sensor needs can be met by combining QCLs and appropriate sensor architectures, those needs ranging from UAV-mounted surveillance systems, through to larger ultra-sensitive systems for airport security. In this paper we provide an overview of various laser-based spectroscopic sensing techniques, pointing out advantages and disadvantages of each. As part of this process, we include our own results and observations for techniques under development at PNNL. We also present the latest performance of our ultra-quiet QCL control electronics now being commercialized, and explore how using optimized supporting electronics enables increased sensor performance and decreased sensor footprint for given applications.

  8. Relativistically induced transparency acceleration of light ions by an ultrashort laser pulse interacting with a heavy-ion-plasma density gradient.

    PubMed

    Sahai, Aakash A; Tsung, Frank S; Tableman, Adam R; Mori, Warren B; Katsouleas, Thomas C

    2013-10-01

    petawatts. The scaling of proton energy with laser power compares favorably to other mechanisms for ultrashort pulses [Schreiber et al., Phys. Rev. Lett. 97, 045005 (2006); Esirkepov et al., Phys. Rev. Lett. 92, 175003 (2004); Silva et al., Phys. Rev. Lett. 92, 015002 (2004); Fiuza et al., Phys. Rev. Lett. 109, 215001 (2012)].

  9. In vitro glucose measurement using tunable mid-infrared laser spectroscopy combined with fiber-optic sensor

    PubMed Central

    Yu, Songlin; Li, Dachao; Chong, Hao; Sun, Changyue; Yu, Haixia; Xu, Kexin

    2013-01-01

    Because mid-infrared (mid-IR) spectroscopy is not a promising method to noninvasively measure glucose in vivo, a method for minimally invasive high-precision glucose determination in vivo by mid-IR laser spectroscopy combined with a tunable laser source and small fiber-optic attenuated total reflection (ATR) sensor is introduced. The potential of this method was evaluated in vitro. This research presents a mid-infrared tunable laser with a broad emission spectrum band of 9.19 to 9.77μm(1024~1088 cm−1) and proposes a method to control and stabilize the laser emission wavelength and power. Moreover, several fiber-optic ATR sensors were fabricated and investigated to determine glucose in combination with the tunable laser source, and the effective sensing optical length of these sensors was determined for the first time. In addition, the sensitivity of this system was four times that of a Fourier transform infrared (FT-IR) spectrometer. The noise-equivalent concentration (NEC) of this laser measurement system was as low as 3.8 mg/dL, which is among the most precise glucose measurements using mid-infrared spectroscopy. Furthermore, a partial least-squares regression and Clarke error grid were used to quantify the predictability and evaluate the prediction accuracy of glucose concentration in the range of 5 to 500 mg/dL (physiologically relevant range: 30~400 mg/dL). The experimental results were clinically acceptable. The high sensitivity, tunable laser source, low NEC and small fiber-optic ATR sensor demonstrate an encouraging step in the work towards precisely monitoring glucose levels in vivo. PMID:24466493

  10. Dental Enamel Irradiated with Infrared Diode Laser and Photoabsorbing Cream: Part 1—FT-Raman Study

    PubMed Central

    Dos Santos, Edson Aparecido Pereira; Soares, Luís Eduardo Silva; Do Espírito Santo, Ana Maria; Martin, Airton Abrahão; Duarte, Danilo Antônio; Pacheco-Soares, Cristina; Brugnera, Aldo

    2009-01-01

    Abstract Objective: The aim of this FT-Raman study was to investigate laser-induced compositional changes in enamel after therapy with a low-level infrared diode laser and a photoabsorbing cream, in order to intensify the superficial light absorption before and after cariogenic challenge. Background Data: Dental caries remains the most prevalent disease during childhood and adolescence. Preventive modalities include the use of fluoride, reduction of dietary cariogenic refined carbohydrates, plaque removal and oral hygiene techniques, and antimicrobial prescriptions. A relatively simple and noninvasive caries preventive regimen is treating tooth enamel with laser irradiation, either alone or in combination with topical fluoride treatment, resulting in reduced enamel solubility and dissolution rates. Due to their high cost, high-powered lasers are still not widely employed in private practice in developing countries. Thus, low-power red and near-infrared lasers appear to be an appealing alternative. Materials and Methods: Twenty-four extracted or exfoliated caries-free deciduous molars were divided into six groups: control group (no treatment; n = 8); infrared laser treatment (L; n = 8) (810 nm at 100 mW/cm2 for 90 sec); infrared diode laser irradiation (810 nm at 100 mW/cm2 for 90 sec) and photoabsorbing cream (IVL; n = 8); photoabsorbing cream alone (IV; n = 8); infrared diode laser irradiation (810 nm at 100 mW/cm2 for 90 sec) and fluorinated photoabsorbing agent (IVLF; n = 8); and fluorinated photoabsorbing agent alone (IVF; n = 8). Samples were analyzed using FT-Raman spectroscopy before and after pH cycling cariogenic challenge. Results: There was a significant laser-induced reduction and possible modification of the organic matrix content in enamel treated with the low-level diode laser (the L, IVL, and IVFL groups). Conclusion: The FT-Raman technique may be suitable for detecting compositional and structural changes

  11. Time-resolved x-ray imaging of a laser-induced nanoplasma and its neutral residuals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fluckiger, L.; Rupp, D.; Adolph, M.

    The evolution of individual, large gas-phase xenon clusters, turned into a nanoplasma by a high power infrared laser pulse, is tracked from femtoseconds up to nanoseconds after laser excitation via coherent diffractive imaging, using ultra-short soft x-ray free electron laser pulses. A decline of scattering signal at high detection angles with increasing time delay indicates a softening of the cluster surface. Here we demonstrate, for the first time a representative speckle pattern of a new stage of cluster expansion for xenon clusters after a nanosecond irradiation. The analysis of the measured average speckle size and the envelope of the intensitymore » distribution reveals a mean cluster size and length scale of internal density fluctuations. Furthermore, the measured diffraction patterns were reproduced by scattering simulations which assumed that the cluster expands with pronounced internal density fluctuations hundreds of picoseconds after excitation.« less

  12. Time-resolved x-ray imaging of a laser-induced nanoplasma and its neutral residuals

    DOE PAGES

    Fluckiger, L.; Rupp, D.; Adolph, M.; ...

    2016-04-13

    The evolution of individual, large gas-phase xenon clusters, turned into a nanoplasma by a high power infrared laser pulse, is tracked from femtoseconds up to nanoseconds after laser excitation via coherent diffractive imaging, using ultra-short soft x-ray free electron laser pulses. A decline of scattering signal at high detection angles with increasing time delay indicates a softening of the cluster surface. Here we demonstrate, for the first time a representative speckle pattern of a new stage of cluster expansion for xenon clusters after a nanosecond irradiation. The analysis of the measured average speckle size and the envelope of the intensitymore » distribution reveals a mean cluster size and length scale of internal density fluctuations. Furthermore, the measured diffraction patterns were reproduced by scattering simulations which assumed that the cluster expands with pronounced internal density fluctuations hundreds of picoseconds after excitation.« less

  13. Ultrashort pulse laser dicing of thin Si wafers: the influence of laser-induced periodic surface structures on the backside breaking strength

    NASA Astrophysics Data System (ADS)

    Domke, Matthias; Egle, Bernadette; Piredda, Giovanni; Stroj, Sandra; Fasching, Gernot; Bodea, Marius; Schwarz, Elisabeth

    2016-11-01

    High power electronic chips are usually fabricated on about 50 µm thin Si wafers to improve heat dissipation. At these chip thicknesses mechanical dicing becomes challenging. Chippings may occur at the cutting edges, which reduce the mechanical stability of the die. Thermal load changes could then lead to sudden chip failure. Ultrashort pulsed lasers are a promising tool to improve the cutting quality, because thermal side effects can be reduced to a minimum. However, laser-induced periodic surface structures occur at the sidewalls and at the trench bottom during scribing. The goal of this study was to investigate the influence of these periodic structures on the backside breaking strength of the die. An ultrafast laser with a pulse duration of 380 fs and a wavelength of 1040 nm was used to cut a wafer into single chips. The pulse energy and the number of scans was varied. The cuts in the wafer were investigated using transmitted light microscopy, the sidewalls of the cut chips were investigated using scanning electron and confocal microscopy, and the breaking strength was evaluated using the 3-point bending test. The results indicated that periodic holes with a distance of about 20-30 µm were formed at the bottom of the trench, if the number of scans was set too low to completely cut the wafer; the wafer was only perforated. Mechanical breaking of the bridges caused 5 µm deep kerfs in the sidewall. These kerfs reduced the breaking strength at the backside of the chip to about 300 MPa. As the number of scans was increased, the bridges were ablated and the wafer was cut completely. Periodic structures were observed on the sidewall; the roughness was below 1 µm. The surface roughness remained on a constant level even when the number of scans was doubled. However, the periodic structures on the sidewall seemed to vanish and the probability to remove local flaws increases with the number of scans. As a consequence, the breaking strength was increased to about

  14. High-gain mid-infrared optical-parametric generation pumped by microchip laser.

    PubMed

    Ishizuki, Hideki; Taira, Takunori

    2016-01-25

    High-gain mid-infrared optical-parametric generation was demonstrated by simple single-pass configuration using PPMgLN devices pumped by giant-pulse microchip laser. Effective mid-infrared wavelength conversion with 1 mJ output energy from 2.4 mJ pumping using conventional PPMgLN could be realized. Broadband optical-parametric generation from 1.7 to 2.6 µm could be also measured using chirped PPMgLN.

  15. Corneal tissue welding with infrared laser irradiation after clear corneal incision.

    PubMed

    Rasier, Rfat; Ozeren, Mediha; Artunay, Ozgür; Bahçecioğlu, Halil; Seçkin, Ismail; Kalaycoğlu, Hamit; Kurt, Adnan; Sennaroğlu, Alphan; Gülsoy, Murat

    2010-09-01

    The aim of this study was to investigate the potential of infrared lasers for corneal welding to seal corneal cuts done in an experimental animal model. Full-thickness corneal cuts on freshly enucleated bovine eyes were irradiated with infrared (809-nm diode, 980-nm diode, 1070-nm YLF, and 1980-nm Tm:YAP) lasers to get immediate laser welding. An 809-nm laser was used with the topical application of indocyanine green to enhance the photothermal interaction at the weld site. In total, 60 bovine eyes were used in this study; 40 eyes were used in the first part of the study for the determination of optimal welding parameters (15 eyes were excluded because of macroscopic carbonization, opacification, or corneal shrinkage; 2 eyes were used for control), and 20 eyes were used for further investigation of more promising lasers (YLF and Tm:YAP). Laser wavelength, irradiating power, exposure time, and spot size were the dose parameters, and optimal dose for immediate closure with minimal thermal damage was estimated through histological examination of welded samples. In the first part of the study, results showed that none of the applications was satisfactory. Full-thickness success rates were 28% (2 of 7) for 809-nm and for 980-nm diode lasers and 67% (2 of 3) for 1070-nm YLF and (4 of 6) for 1980-nm Tm:YAP lasers. In the second part of the study, YLF and Tm:YAP lasers were investigated with bigger sample size. Results were not conclusive but promising again. Five corneal incisions were full-thickness welded out of 10 corneas with 1070-nm laser, and 4 corneal incisions were partially welded out of 10 corneas with 1980-nm laser in the second part of the study. Results showed that noteworthy corneal welding could be obtained with 1070-nm YLF laser and 1980-nm Tm:YAP laser wavelengths. Furthermore, in vitro and in vivo studies will shed light on the potential usage of corneal laser welding technique.

  16. Cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser.

    PubMed

    Alexsandra da Silva Neto Trajano, Larissa; da Silva, Camila Luna; de Carvalho, Simone Nunes; Cortez, Erika; Mencalha, André Luiz; de Souza da Fonseca, Adenilson; Stumbo, Ana Carolina

    2016-07-01

    Low-level infrared laser is considered safe and effective for treatment of muscle injuries. However, the mechanism involved on beneficial effects of laser therapy are not understood. The aim was to evaluate cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser at therapeutic fluences. C2C12 myoblast cultures at different (2 and 10 %) fetal bovine serum (FBS) concentrations were exposed to low-level infrared laser (808 nm, 100 mW) at different fluences (10, 35, and 70 J/cm(2)) and evaluated after 24, 48, and 72 h. Cell viability was evaluated by WST-1 assay; reactive oxygen species (ROS), apoptosis, and necrosis were evaluated by flow cytometry. Cell viability was decreased atthe lowest FBS concentration. Laser exposure increased the cell viability in myoblast cultures at 2 % FBS after 48 and 72 h, but no significant increase in ROS was observed. Apoptosis was decreased at the higher fluence and necrosis was increased at lower fluence in myoblast cultures after 24 h of laser exposure at 2 % FBS. No laser-induced alterations were obtained at 10 % FBS. Results show that level of reactive oxygen species is not altered, at least to those evaluated in this study, but low-level infrared laser exposure affects cell viability, apoptosis, and necrosis in myoblast cultures depending on laser fluence and physiologic conditions of cells.

  17. Ultrashort pulsed laser (USPL) application in dentistry: basic investigations of ablation rates and thresholds on oral hard tissue and restorative materials.

    PubMed

    Schelle, Florian; Polz, Sebastian; Haloui, Hatim; Braun, Andreas; Dehn, Claudia; Frentzen, Matthias; Meister, Jörg

    2014-11-01

    Modern ultrashort pulse lasers with scanning systems provide a huge set of parameters affecting the suitability for dental applications. The present study investigates thresholds and ablation rates of oral hard tissues and restorative materials with a view towards a clinical application system. The functional system consists of a 10 W Nd:YVO4 laser emitting pulses with a duration of 8 ps at 1,064 nm. Measurements were performed on dentin, enamel, ceramic, composite, and mammoth ivory at a repetition rate of 500 kHz. By employing a scanning system, square-shaped cavities with an edge length of 1 mm were created. Ablation threshold and rate measurements were assessed by variation of the applied fluence. Examinations were carried out employing a scanning electron microscope and optical profilometer. Irradiation time was recorded by the scanner software in order to calculate the overall ablated volume per time. First high power ablation rate measurements were performed employing a laser source with up to 50 W. Threshold values in the range of 0.45 J/cm(2) (composite) to 1.54 J/cm(2) (enamel) were observed. Differences between any two materials are statistically significant (p < 0.05). Preparation speeds up to 37.53 mm(3)/min (composite) were achieved with the 10 W laser source and differed statistically significant for any two materials (p < 0.05) with the exception of dentin and mammoth ivory (p > 0.05). By employing the 50 W laser source, increased rates up to ∼50 mm(3)/min for dentin were obtained. The results indicate that modern USPL systems provide sufficient ablation rates to be seen as a promising technology for dental applications.

  18. Novel THz radiation from relativistic laser-plasmas

    NASA Astrophysics Data System (ADS)

    Sheng, Z. M.; Wu, H. C.; Wang, W. M.; Dong, X. G.; Chen, M.; Zhang, J.

    2009-05-01

    The interaction of ultrashort intense laser pulses with plasma can produce electromagnetic radiation of ultra-broad spectra ranging from terahertz (THz) radiation to keV x-rays and beyond. Here we present a review of our recent theoretical and numerical investigation on high power THz generation from tenuous plasma or gas targets irradiated by ultrashort intense laser pulses. Three mechanisms of THz emission are addressed, which include the linear mode conversion from laser wakefields in inhomogeneous plasma, transient current emission at the plasma-vacuum boundaries, and the emission from residual transverse currents produced by temporally-asymmetric laser pulses passing through gas or plasma targets. Since there is no breakdown limit for plasma under the irradiation of high power lasers, in principle, all these mechanisms can lead to terahertz pulse emission at the power of beyond megawatt with the field strength of MV/cm, suitable for the study of high THz field physics and other applications.

  19. Dental Enamel Irradiated with Infrared Diode Laser and Photo-Absorbing Cream: Part 2—EDX Study

    PubMed Central

    dos Santos, Edson Aparecido Pereira; Soares, Luís Eduardo Silva; do Espírito Santo, Ana Maria; Martin, Airton Abrahão; Duarte, Danilo Antônio; Pacheco-Soares, Cristina; Brugnera, Aldo

    2009-01-01

    Abstract Objective: The effects of laser-induced compositional changes on the enamel were investigated by energy-dispersive X-ray fluorescence spectrometry (μ-EDX). After cariogenic challenge, we administered treatment of low-level infrared diode laser and a photo-absorbing cream (used to intensify the superficial light absorption). Background Data: Dental caries is considered the most prevalent oral disease. A simple and noninvasive caries preventive regimen is treating tooth enamel with a laser, either alone or in combination with fluoride, which reduces enamel solubility and dissolution rates. High power lasers are still not widely used in private practice. Low-power near-infrared lasers may be an alternative approach. Energy-dispersive μ-EDX is a versatile and nondestructive spectroscopic technique that allows for a qualitative and quantitative elemental analysis of inorganic enamel components, such as calcium and phosphorus. Materials and Methods: Twenty-four extracted or exfoliated caries-free deciduous molars were divided into six groups: 1) control group (CTR-no treatment); 2) infrared laser treatment (L) (λ = 810 nm, 100 mW/cm2, 90 sec, 4.47 J/cm2, 9 J); 3) infrared laser irradiation and photo-absorbing agent (CL); 4) photo-absorbing agent alone (C); 5) infrared laser irradiation and fluoridated photo-absorbing agent (FCL); and 6) fluoridated photo-absorbing agent alone (FC). Samples were analyzed using μ-EDX after two sets of treatments and pH cycling cariogenic challenges. Results: The CL group showed statistically significant increases in calcium and phosphorus (wt%) compared with the CTR group. The Ca/P ratio was similar in the FCL and CTR groups. There was a significant laser-induced reduction compared with the CTR group, and there was a possible modification of the organic balance content in enamel treated with laser and cream. Conclusion: μ-EDX may be able to detect compositional changes in mineral phases of lased enamel under

  20. Ultrashort optical waveguide excitations in uniaxial silica fibers: elastic collision scenarios.

    PubMed

    Kuetche, Victor K; Youssoufa, Saliou; Kofane, Timoleon C

    2014-12-01

    In this work, we investigate the dynamics of an uniaxial silica fiber under the viewpoint of propagation of ultimately ultrashort optical waveguide channels. As a result, we unveil the existence of three typical kinds of ultrabroadband excitations whose profiles strongly depend upon their angular momenta. Looking forward to surveying their scattering features, we unearth some underlying head-on scenarios of elastic collisions. Accordingly, we address some useful and straightforward applications in nonlinear optics through secured data transmission systems, as well as laser physics and soliton theory with optical soliton dynamics.

  1. Laser-Induced Breakdown Spectroscopy Infrared Emission From Inorganic and Organic Substances

    DTIC Science & Technology

    2006-11-01

    using a liquid-nitrogen cooled indium antimonide (InSb) detector and the signal was recorded using a gated electronic circuit (boxcar averager). All...contaminants by analyzing the atomic spectral emission lines that result subsequent to plasmas generated by laser power. The ultraviolet-visible-near infrared...UV- Vis-NIR) spectral region exploited in conventional LIBS largely elucidates the elemental composition of the laser target by profiling these

  2. Short pulse fiber lasers mode-locked by carbon nanotubes and graphene

    NASA Astrophysics Data System (ADS)

    Yamashita, Shinji; Martinez, Amos; Xu, Bo

    2014-12-01

    One and two dimensional forms of carbon, carbon nanotubes and graphene, have interesting and useful, not only electronic but also photonic, properties. For fiber lasers, they are very attractive passive mode lockers for ultra-short pulse generation, since they have saturable absorption with inherently fast recovery time (<1 ps). In this paper, we review the photonic properties of graphene and CNT and our recent works on fabrication of fiber devices and applications to ultra-short pulse mode-locked fiber lasers.

  3. Optical circular deflector with attosecond resolution for ultrashort electron beam

    DOE PAGES

    Zhang, Zhen; Du, Yingchao; Tang, Chuanxiang; ...

    2017-05-25

    A novel method using high-power laser as a circular deflector is proposed for the measurement of femtosecond (fs) and sub-fs electron beam. In the scheme, the electron beam interacts with a laser pulse operating in a radially polarized doughnut mode ( TEM 01 * ) in a helical undulator, generating angular kicks along the beam in two directions at the same time. The phase difference between the two angular kicks makes the beam form a ring after a propagation section with appropriate phase advance, which can reveal the current profile of the electron beam. Detailed theoretical analysis of the methodmore » and numerical results with reasonable parameters are both presented. Lastly, it is shown that the temporal resolution can reach up to ~ 100 attosecond, which is a significant improvement for the diagnostics of ultrashort electron beam.« less

  4. Optical circular deflector with attosecond resolution for ultrashort electron beam

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Zhen; Du, Yingchao; Tang, Chuanxiang

    A novel method using high-power laser as a circular deflector is proposed for the measurement of femtosecond (fs) and sub-fs electron beam. In the scheme, the electron beam interacts with a laser pulse operating in a radially polarized doughnut mode ( TEM 01 * ) in a helical undulator, generating angular kicks along the beam in two directions at the same time. The phase difference between the two angular kicks makes the beam form a ring after a propagation section with appropriate phase advance, which can reveal the current profile of the electron beam. Detailed theoretical analysis of the methodmore » and numerical results with reasonable parameters are both presented. Lastly, it is shown that the temporal resolution can reach up to ~ 100 attosecond, which is a significant improvement for the diagnostics of ultrashort electron beam.« less

  5. Particle in cell simulation on plasma grating contrast enhancement induced by infrared laser pulse

    NASA Astrophysics Data System (ADS)

    Li, M.; Yuan, T.; Xu, Y. X.; Wang, J. X.; Luo, S. N.

    2018-05-01

    The dynamics of plasma grating contrast enhancement (PGCE) irradiated by an infrared laser pulse is investigated with one dimensional particle-in-cell simulation where field ionization and impact ionization are simultaneously considered for the first time. The numeric results show that the impact ionization dominates the PGCE process. Upon the interaction with the laser pulse, abundant free electrons are efficiently accelerated and subsequently triggered massive impact ionizations in the density ridges of the plasma grating for the higher local plasma energy density, which efficiently enhances the grating contrast. Besides the dynamic analysis of PGCE, we explore the parameter space of the incident infrared laser pulse to optimize the PGCE effect, which can provide useful guidance to experiments related to laser-plasma-grating interactions and may find applications in prolonging the duration of the plasma grating.

  6. Towards diode-pumped mid-infrared praseodymium-ytterbium-doped fluoride fiber lasers

    NASA Astrophysics Data System (ADS)

    Woodward, R. I.; Hudson, D. D.; Jackson, S. D.

    2018-02-01

    We explore the potential of a new mid-infrared laser transition in praseodymium-doped fluoride fiber for emission around 3.4 μm, which can be conveniently pumped by 0.975 μm diodes via ytterbium sensitizer co-doping. Optimal cavity designs are determined through spectroscopic measurements and numerical modeling, suggesting that practical diode-pumped watt-level mid-infrared fiber sources beyond 3 μm could be achieved.

  7. Mid-infrared supercontinuum generation in As2S3-silica "nano-spike" step-index waveguide.

    PubMed

    Granzow, N; Schmidt, M A; Chang, W; Wang, L; Coulombier, Q; Troles, J; Toupin, P; Hartl, I; Lee, K F; Fermann, M E; Wondraczek, L; Russell, P St J

    2013-05-06

    Efficient generation of a broad-band mid-infrared supercontinuum spectrum is reported in an arsenic trisulphide waveguide embedded in silica. A chalcogenide "nano-spike", designed to transform the incident light adiabatically into the fundamental mode of a 2-mm-long uniform section 1 µm in diameter, is used to achieve high launch efficiencies. The nano-spike is fully encapsulated in a fused silica cladding, protecting it from the environment. Nano-spikes provide a convenient means of launching light into sub-wavelength scale waveguides. Ultrashort (65 fs, repetition rate 100 MHz) pulses at wavelength 2 µm, delivered from a Tm-doped fiber laser, are launched with an efficiency ~12% into the sub-wavelength chalcogenide waveguide. Soliton fission and dispersive wave generation along the uniform section result in spectral broadening out to almost 4 µm for launched energies of only 18 pJ. The spectrum generated will have immediate uses in metrology and infrared spectroscopy.

  8. Assignment of far-infrared laser lines of O-17 methanol by synchrotron FTIR spectroscopy and laser frequency measurements

    NASA Astrophysics Data System (ADS)

    Lees, R. M.; Jackson, M.; Moruzzi, G.; Predoi-Cross, Adriana; Billinghurst, B. E.

    2015-09-01

    Analysis of synchrotron FTIR spectra has revealed new assignments for a number of optically pumped far-infrared laser lines from the CH317OH isotopologue of methanol, with definitive confirmation provided by recent accurate measurements of the laser frequencies. In this Note the lasing energy level systems are discussed, and the spectroscopic evidence for the assignments is presented.

  9. Defects diagnosis in laser brazing using near-infrared signals based on empirical mode decomposition

    NASA Astrophysics Data System (ADS)

    Cheng, Liyong; Mi, Gaoyang; Li, Shuo; Wang, Chunming; Hu, Xiyuan

    2018-03-01

    Real-time monitoring of laser welding plays a very important role in the modern automated production and online defects diagnosis is necessary to be implemented. In this study, the status of laser brazing was monitored in real time using an infrared photoelectric sensor. Four kinds of braze seams (including healthy weld, unfilled weld, hole weld and rough surface weld) along with corresponding near-infrared signals were obtained. Further, a new method called Empirical Mode Decomposition (EMD) was proposed to analyze the near-infrared signals. The results showed that the EMD method had a good performance in eliminating the noise on the near-infrared signals. And then, the correlation coefficient was developed for selecting the Intrinsic Mode Function (IMF) more sensitive to the weld defects. A more accurate signal was reconstructed with the selected IMF components. Simultaneously, the spectrum of selected IMF components was solved using fast Fourier transform, and the frequency characteristics were clearly revealed. The frequency energy of different frequency bands was computed to diagnose the defects. There was a significant difference in four types of weld defects. This approach has been proved to be an effective and efficient method for monitoring laser brazing defects.

  10. Infrared Laser Optoacoustic Detection Of Gases And Vapours

    NASA Astrophysics Data System (ADS)

    Johnson, S. A.; Cummins, P. G.; Bone, S. A.; Davies, P. B.

    1988-10-01

    Mid-infrared laser optoacoustic spectroscopy has been used to detect a variety of gases and vapours. Performance was calibrated using the signal from a known concentration of ethene, and then the method applied to the perfume alcohol geraniol. Detection limits were found to be 1 ppb for ethene and 70 ppb for geraniol on their strongest absorption lines for a few seconds measurement time.

  11. Low intensity infrared laser affects expression of oxidative DNA repair genes in mitochondria and nucleus

    NASA Astrophysics Data System (ADS)

    Fonseca, A. S.; Magalhães, L. A. G.; Mencalha, A. L.; Geller, M.; Paoli, F.

    2014-11-01

    Practical properties and physical characteristics of low intensity lasers have made possible their application to treat soft tissue diseases. Excitation of intracellular chromophores by red and infrared radiation at low energy fluences with increase of mitochondrial metabolism is the basis of the biostimulation effect but free radicals can be produced. DNA lesions induced by free radicals are repaired by the base excision repair pathway. In this work, we evaluate the expression of POLγ and APEX2 genes related to repair of mitochondrial and nuclear DNA, respectively. Skin and muscle tissue of Wistar rats were exposed to low intensity infrared laser at different fluences. One hour and 24 hours after laser exposure, tissue samples were withdrawn for total RNA extraction, cDNA synthesis, and evaluation of POLγ and APEX2 mRNA expression by real time quantitative polymerase chain reaction. Skin and muscle tissue of Wistar rats exposed to laser radiation show different expression of POLγ and APEX2 mRNA depending of the fluence and time after exposure. Our study suggests that a low intensity infrared laser affects expression of genes involved in repair of oxidative lesions in mitochondrial and nuclear DNA.

  12. Ultrashort polarization-tailored bichromatic fields from a CEP-stable white light supercontinuum.

    PubMed

    Kerbstadt, Stefanie; Timmer, Daniel; Englert, Lars; Bayer, Tim; Wollenhaupt, Matthias

    2017-05-29

    We apply ultrafast polarization shaping to an ultrabroadband carrier envelope phase (CEP) stable white light supercontinuum to generate polarization-tailored bichromatic laser fields of low-order frequency ratio. The generation of orthogonal linearly and counter-rotating circularly polarized bichromatic fields is achieved by introducing a composite polarizer in the Fourier plane of a 4 f polarization shaper. The resulting Lissajous- and propeller-type polarization profiles are characterized experimentally by cross-correlation trajectories. The scheme provides full control over all bichromatic parameters and allows for individual spectral phase modulation of both colors. Shaper-based CEP control and the generation of tailored bichromatic fields is demonstrated. These bichromatic CEP-stable polarization-shaped ultrashort laser pulses provide a versatile class of waveforms for coherent control experiments.

  13. Laser-driven plasma photonic crystals for high-power lasers

    NASA Astrophysics Data System (ADS)

    Lehmann, G.; Spatschek, K. H.

    2017-05-01

    Laser-driven plasma density gratings in underdense plasma are shown to act as photonic crystals for high power lasers. The gratings are created by counterpropagating laser beams that trap electrons, followed by ballistic ion motion. This leads to strong periodic plasma density modulations with a lifetime on the order of picoseconds. The grating structure is interpreted as a plasma photonic crystal time-dependent property, e.g., the photonic band gap width. In Maxwell-Vlasov and particle-in-cell simulations it is demonstrated that the photonic crystals may act as a frequency filter and mirror for ultra-short high-power laser pulses.

  14. Subsurface thermal coagulation of tissues using near infrared lasers

    NASA Astrophysics Data System (ADS)

    Chang, Chun-Hung Jack

    Noninvasive laser therapy is currently limited primarily to cosmetic dermatological applications such as skin resurfacing, hair removal, tattoo removal and treatment of vascular birthmarks. In order to expand applications of noninvasive laser therapy, deeper optical penetration of laser radiation in tissue as well as more aggressive cooling of the tissue surface is necessary. The near-infrared laser wavelength of 1075 nm was found to be the optimal laser wavelength for creation of deep subsurface thermal lesions in liver tissue, ex vivo, with contact cooling, preserving a surface tissue layer of 2 mm. Monte Carlo light transport, heat transfer, and Arrhenius integral thermal damage simulations were conducted at this wavelength, showing good agreement between experiment and simulations. Building on the initial results, our goal is to develop new noninvasive laser therapies for application in urology, specifically for treatment of female stress urinary incontinence (SUI). Various laser balloon probes including side-firing and diffusing fibers were designed and tested for both transvaginal and transurethral approaches to treatment. The transvaginal approach showed the highest feasibility. To further increase optical penetration depth, various types and concentrations of optical clearing agents were also explored. Three cadavers studies were performed to investigate and demonstrate the feasibility of laser treatment for SUI.

  15. Mid-infrared gas absorption sensor based on a broadband external cavity quantum cascade laser

    NASA Astrophysics Data System (ADS)

    Sun, Juan; Deng, Hao; Liu, Ningwu; Wang, Hongliang; Yu, Benli; Li, Jingsong

    2016-12-01

    We developed a laser absorption sensor based on a pulsed, broadband tunable external cavity quantum cascade laser (ECQCL) centered at 1285 cm-1. Unlike traditional infrared spectroscopy system, a quartz crystal tuning fork (QCTF) as a light detector was used for laser signal detection. Fast Fourier transform was applied to extract vibration intensity information of QCTF. The sensor system is successfully tested on nitrous oxide (N2O) spectroscopy measurements and compared with a standard infrared detector. The wide wavelength tunability of ECQCL will allow us to access the fundamental vibrational bands of many chemical agents, which are well-suited for trace explosive, chemical warfare agent, and toxic industrial chemical detection and spectroscopic analysis.

  16. Mid-infrared gas absorption sensor based on a broadband external cavity quantum cascade laser.

    PubMed

    Sun, Juan; Deng, Hao; Liu, Ningwu; Wang, Hongliang; Yu, Benli; Li, Jingsong

    2016-12-01

    We developed a laser absorption sensor based on a pulsed, broadband tunable external cavity quantum cascade laser (ECQCL) centered at 1285 cm -1 . Unlike traditional infrared spectroscopy system, a quartz crystal tuning fork (QCTF) as a light detector was used for laser signal detection. Fast Fourier transform was applied to extract vibration intensity information of QCTF. The sensor system is successfully tested on nitrous oxide (N 2 O) spectroscopy measurements and compared with a standard infrared detector. The wide wavelength tunability of ECQCL will allow us to access the fundamental vibrational bands of many chemical agents, which are well-suited for trace explosive, chemical warfare agent, and toxic industrial chemical detection and spectroscopic analysis.

  17. High power parallel ultrashort pulse laser processing

    NASA Astrophysics Data System (ADS)

    Gillner, Arnold; Gretzki, Patrick; Büsing, Lasse

    2016-03-01

    The class of ultra-short-pulse (USP) laser sources are used, whenever high precession and high quality material processing is demanded. These laser sources deliver pulse duration in the range of ps to fs and are characterized with high peak intensities leading to a direct vaporization of the material with a minimum thermal damage. With the availability of industrial laser source with an average power of up to 1000W, the main challenge consist of the effective energy distribution and disposition. Using lasers with high repetition rates in the MHz region can cause thermal issues like overheating, melt production and low ablation quality. In this paper, we will discuss different approaches for multibeam processing for utilization of high pulse energies. The combination of diffractive optics and conventional galvometer scanner can be used for high throughput laser ablation, but are limited in the optical qualities. We will show which applications can benefit from this hybrid optic and which improvements in productivity are expected. In addition, the optical limitations of the system will be compiled, in order to evaluate the suitability of this approach for any given application.

  18. [Application of mid-infrared wavelength tunable laser in glucose determination].

    PubMed

    Yu, Song-Lin; Li, Da-Chao; Zhong, Hao; Sun, Chang-Yue; Xu, Ke-Xin

    2013-04-01

    The authors proposed a method of control and stabilization for laser emission wavelengths and power, and presented the mid-infrared wavelength tunable laser with broad emission spectrum band of 9.19-9.77 microm, half wave width of 4 cm(-1), spectral resolution of 2.7 x 10(4) and max power of 800 mW with fluctuation < 0.8% in the present paper. The tunable laser was employed as the light source in combination with ATR sensor for glucose measurement in PBS solution. In our experiments, absorbance at the five laser emission wavelengths, including 1 081, 1 076, 1 051, 1 041 and 1 037 cm(-1) in the 9R and 9P band of the laser emission spectrum, all correlates well with the glucose concentration (R2 > 0.99, SD < 0.0004, P < 0.000 1). Especially, the sensitivity of this laser spectroscopy system is about 4 times as high as that of traditional FTIR spectrometer.

  19. Design on compatible stealth photonic crystal of nearmiddle infrared and 1.06 μm laser

    NASA Astrophysics Data System (ADS)

    Zhang, Ji-kui; Wang, Jia-Chun; Wang, Qi-Chao

    2016-01-01

    In the near and middle infrared atmospheric window, infrared stealth material require a low absorptivity (which means a low emissivity according to Kirchhoff's law of black body), at the same time, it also requires high absorptivity so as to decrease the reflectance at military laser wavelength of 1.06μm. Under this circumstances, compatible stealth of infrared and laser is an urgent demand, but the demand is ambivalent for conventional materials. Photonic crystal (PC), as a new type of artificial periodic structure function material, can realize broadband thermal infrared stealth based on its high-reflection photon forbidden band(also called photonic band gap). The high-reflection photon forbidden band of PC can be adjusted to near and middle infrared wave band through some rational methods. When a defect was added into the periodic structure of PC, a "hole-digging" reflection spectrum, which is high absorption at military laser wavelength of 1.06μm, can be achieved, so compatible stealth of near and middle infrared and military laser wavelength of 1.06μm can be achieved too. In this paper, we selected near and middle infrared-transparent materials, Te and MgF2 , as high refractive index and low refractive index material respectively, and designed a one-dimensional one-defect-mode PC whose photon forbidden band was broadened to 1-5μm by constructing two photonic crystals into one. The optical property of the PC was calculated by Transfer matrix method(TMM) of thin-film optical theory, and the results shows that the as-designed PC has a high spectral reflectance in the near and middle infrared band, among which the reflectivity in 1.68μm 5.26μm band reached more than 90%, and the 2.48 5.07μm band even reached 99.99%. The result also shows that between the band gap of 1-5μm, there are one defect mode locating in the wavelength of 1.06μm, whose reflectance is below 0.70%, which means its spectral absorptivity is greater than 99.30%. All the above we have

  20. Medical applications of ultra-short pulse lasers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, B M; Marion, J E

    1999-06-08

    The medical applications for ultra short pulse lasers (USPLs) and their associated commercial potential are reviewed. Short pulse lasers offer the surgeon the possibility of precision cutting or disruption of tissue with virtually no thermal or mechanical damage to the surrounding areas. Therefore the USPL offers potential improvement to numerous existing medical procedures. Secondly, when USPLs are combined with advanced tissue diagnostics, there are possibilities for tissue-selective precision ablation that may allow for new surgeries that cannot at present be performed. Here we briefly review the advantages of short pulse lasers, examine the potential markets both from an investment communitymore » perspective, and from the view. of the technology provider. Finally nominal performance and cost requirements for the lasers, delivery systems and diagnostics and the present state of development will be addressed.« less

  1. Closure of skin incisions by laser-welding with a combination of two near-infrared diode lasers: preliminary study for determination of optimal parameters

    NASA Astrophysics Data System (ADS)

    Hu, Liming; Lu, Zhihua; Wang, Biao; Cao, Junsheng; Ma, Xiaobo; Tian, Zhenhua; Gao, Zhijian; Qin, Li; Wu, Xiaodong; Liu, Yun; Wang, Lijun

    2011-03-01

    Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were made on the Wistar rat's dorsal skin. The efficiencies of laser-welding with different parameters were investigated. Incision-healing, histology examination, and a tensile strength test of incisions were recorded. Laser welding with the irradiance level of 15.9 W/cm2 for both 980 and 1064-nm lasers and exposure time of 5 s per spot in continuous wave mode yielded a more effective closure and healing with minimal thermal damage, faster recovery, and stronger apposition in comparison with a suturing technique. The conclusion is that skin welding with a combination of two near-infrared diode lasers can be a good candidate for incision closure, and further investigations are in progress for clinical use.

  2. Closure of skin incisions by laser-welding with a combination of two near-infrared diode lasers: preliminary study for determination of optimal parameters.

    PubMed

    Hu, Liming; Lu, Zhihua; Wang, Biao; Cao, Junsheng; Ma, Xiaobo; Tian, Zhenhua; Gao, Zhijian; Qin, Li; Wu, Xiaodong; Liu, Yun; Wang, Lijun

    2011-03-01

    Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were made on the Wistar rat's dorsal skin. The efficiencies of laser-welding with different parameters were investigated. Incision-healing, histology examination, and a tensile strength test of incisions were recorded. Laser welding with the irradiance level of 15.9 W∕cm(2) for both 980 and 1064-nm lasers and exposure time of 5 s per spot in continuous wave mode yielded a more effective closure and healing with minimal thermal damage, faster recovery, and stronger apposition in comparison with a suturing technique. The conclusion is that skin welding with a combination of two near-infrared diode lasers can be a good candidate for incision closure, and further investigations are in progress for clinical use.

  3. Coherent infrared radiation from the ALS generated via femtosecond laser modulation of the electron beam

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Byrd, J.M.; Hao, Z.; Martin, M.C.

    2004-07-01

    Interaction of an electron beam with a femtosecond laser pulse co-propagating through a wiggler at the ALS produces large modulation of the electron energies within a short {approx}100 fs slice of the electron bunch. Propagating around the storage ring, this bunch develops a longitudinal density perturbation due to the dispersion of electron trajectories. The length of the perturbation evolves with a distance from the wiggler but is much shorter than the electron bunch length. This perturbation causes the electron bunch to emit short pulses of temporally and spatially coherent infrared light which are automatically synchronized to the modulating laser. Themore » intensity and spectra of the infrared light were measured in two storage ring locations for a nominal ALS lattice and for an experimental lattice with the higher momentum compaction factor. The onset of instability stimulated by laser e-beam interaction had been discovered. The infrared signal is now routinely used as a sensitive monitor for a fine tuning of the laser beam alignment during data accumulation in the experiments with femtosecond x-ray pulses.« less

  4. Influence of the initial surface texture on the resulting surface roughness and waviness for micro-machining with ultra-short laser pulses (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Remund, Stefan M.; Jaeggi, Beat; Kramer, Thorsten; Neuenschwander, Beat

    2017-03-01

    The resulting surface roughness and waviness after processing with ultra-short pulsed laser radiation depend on the laser parameters as well as on the machining strategy and the scanning system. However the results depend on the material and its initial surface quality and finishing as well. The improvement of surface finishing represents effort and produces additional costs. For industrial applications it is important to reduce the preparation of a workpiece for laser micro-machining to optimize quality and reduce costs. The effects of the ablation process and the influence of the machining strategy and scanning system onto the surface roughness and waviness can be differenced due to their separate manner. By using the optimal laser parameters on an initially perfect surface, the ablation process mainly increases the roughness to a certain value for most metallic materials. However, imperfections in the scanning system causing a slight variation in the scanning speed lead to a raise of the waviness on the sample surface. For a basic understanding of the influence of grinding marks, the sample surfaces were initially furnished with regular grooves of different depths and spatial frequencies to gain a homogenous and well-defined original surface. On these surfaces the effect of different beam waists and machining strategy are investigated and the results are compared with a simulation of the process. Furthermore the behaviors of common surface finishes used in industrial applications for laser micro-machining are studied and the relation onto the resulting surface roughness and waviness is presented.

  5. Several new directions for ultrafast fiber lasers [Invited].

    PubMed

    Fu, Walter; Wright, Logan G; Sidorenko, Pavel; Backus, Sterling; Wise, Frank W

    2018-04-16

    Ultrafast fiber lasers have the potential to make applications of ultrashort pulses widespread - techniques not only for scientists, but also for doctors, manufacturing engineers, and more. Today, this potential is only realized in refractive surgery and some femtosecond micromachining. The existing market for ultrafast lasers remains dominated by solid-state lasers, primarily Ti:sapphire, due to their superior performance. Recent advances show routes to ultrafast fiber sources that provide performance and capabilities equal to, and in some cases beyond, those of Ti:sapphire, in compact, versatile, low-cost devices. In this paper, we discuss the prospects for future ultrafast fiber lasers built on new kinds of pulse generation that capitalize on nonlinear dynamics. We focus primarily on three promising directions: mode-locked oscillators that use nonlinearity to enhance performance; systems that use nonlinear pulse propagation to achieve ultrashort pulses without a mode-locked oscillator; and multimode fiber lasers that exploit nonlinearities in space and time to obtain unparalleled control over an electric field.

  6. Infrared Laser Ablation with Vacuum Capture for Fingermark Sampling

    NASA Astrophysics Data System (ADS)

    Donnarumma, Fabrizio; Camp, Eden E.; Cao, Fan; Murray, Kermit K.

    2017-09-01

    Infrared laser ablation coupled to vacuum capture was employed to collect material from fingermarks deposited on surfaces of different porosity and roughness. Laser ablation at 3 μm was performed in reflection mode with subsequent capture of the ejecta with a filter connected to vacuum. Ablation and capture of standards from fingermarks was demonstrated on glass, plastic, aluminum, and cardboard surfaces. Using matrix assisted laser desorption ionization (MALDI), it was possible to detect caffeine after spiking with amounts as low as 1 ng. MALDI detection of condom lubricants and detection of antibacterial peptides from an antiseptic cream was demonstrated. Detection of explosives from fingermarks left on plastic surfaces as well as from direct deposition on the same surface using gas chromatography mass spectrometry (GC-MS) was shown. [Figure not available: see fulltext.

  7. Infrared Laser Ablation with Vacuum Capture for Fingermark Sampling.

    PubMed

    Donnarumma, Fabrizio; Camp, Eden E; Cao, Fan; Murray, Kermit K

    2017-09-01

    Infrared laser ablation coupled to vacuum capture was employed to collect material from fingermarks deposited on surfaces of different porosity and roughness. Laser ablation at 3 μm was performed in reflection mode with subsequent capture of the ejecta with a filter connected to vacuum. Ablation and capture of standards from fingermarks was demonstrated on glass, plastic, aluminum, and cardboard surfaces. Using matrix assisted laser desorption ionization (MALDI), it was possible to detect caffeine after spiking with amounts as low as 1 ng. MALDI detection of condom lubricants and detection of antibacterial peptides from an antiseptic cream was demonstrated. Detection of explosives from fingermarks left on plastic surfaces as well as from direct deposition on the same surface using gas chromatography mass spectrometry (GC-MS) was shown. Graphical Abstract ᅟ.

  8. High Efficiency, Room Temperature Mid-Infrared Semiconductor Laser Development for IR Countermeasures

    DTIC Science & Technology

    2009-05-01

    voltage (I-V) characteristics of several infrared LEDs, including a type-II W-well laser grown by Molecular Beam Epitaxy at Naval Research Laboratory...Injection Cavity (OPIC) lasers includes >4 um emission from a broadband laser and the measurement of spatial and temporal beam profiles. From August 2006...argon) at 15 mTorr, 400W ICP, and 70W RIE power, with an etch rate of 300 nm/min. Epitaxial ZnO layers were plasma etched using BCl3/SF0gas mixtures

  9. Study on laser and infrared attenuation performance of carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Liu, Xiang-cui; Liu, Qing-hai; Dai, Meng-yan; Cheng, Xiang; Fang, Guo-feng; Zhang, Tong; Liu, Haifeng

    2014-11-01

    In recent years, the weapon systems of laser and infrared (IR) imaging guidance have been widely used in modern warfare because of their high precision and strong anti-interference. However, military smoke, a rapid and effective passive jamming method, can effectively counteract the attack of precision-guided weapons by their scattering and absorbing effects. The traditional smoke has good visible light (0.4-0.76μm) obscurant performance, but hardly any effects to other electromagnetic wave bands while the weapon systems of laser and IR imaging guidance usually work in broad band, including the near-infrared (1-3μm), middle-infrared (3-5μm), far-infrared (8-14μm), and so on. Accordingly, exploiting new effective obscurant materials has attracted tremendous interest worldwide nowadays. As is known, the nano-structured materials have lots of unique properties comparing with the traditional materials suggesting that they might be the perfect alternatives to solve the problems above. Carbon nanotubes (CNTs) are well-ordered, all-carbon hollow graphitic nano-structured materials with a high aspect ratio, lengths from several hundred nanometers to several millimeters. CNTs possess many unique intrinsic physical-chemical properties and are investigated in many areas reported by the previous studies. However, no application research about CNTs in smoke technology field is reported yet. In this paper, the attenuation performances of CNTs smoke to laser and IR were assessed in 20m3 smoke chamber. The testing wavebands employed in experiments are 1.06μm and 10.6μm laser, 3-5μm and 8-14μm IR radiation. The main parameters were obtained included the attenuation rate, transmission rate, mass extinction coefficient, etc. The experimental results suggest that CNTs smoke exhibits excellent attenuation ability to the broadband IR radiation. Their mass extinction coefficients are all above 1m2·g-1. Nevertheless, the mass extinction coefficients vary with the sampling time

  10. Sub-cycle steering of the deprotonation of acetylene by intense few-cycle mid-infrared laser fields.

    PubMed

    Li, H; Kling, Nora G; Gaumnitz, T; Burger, C; Siemering, R; Schötz, J; Liu, Q; Ban, L; Pertot, Y; Wu, J; Azzeer, A M; de Vivie-Riedle, R; Wörner, H J; Kling, M F

    2017-06-26

    Directional breaking of the C-H/C-D molecular bond is manipulated in acetylene (C 2 H 2 ) and deuterated acetylene (C 2 D 2 ) by waveform controlled few-cycle mid-infrared laser pulses with a central wavelength around 1.6 μm at an intensity of about 8 × 10 13 W/cm 2 . The directionality of the deprotonation of acetylene is controlled by changing the carrier-envelope phase (CEP). The CEP-control can be attributed to the laser-induced superposition of vibrational modes, which is sensitive to the sub-cycle evolution of the laser waveform. Our experiments and simulations indicate that near-resonant, intense mid-infrared pulses permit a higher degree of control of the directionality of the reaction compared to those obtained in near-infrared fields, in particular for the deuterated species.

  11. Diode laser-induced infrared fluorescence of water vapour

    NASA Astrophysics Data System (ADS)

    Li, Hejie; Hanson, Ronald K.; Jeffries, Jay B.

    2004-07-01

    Infrared laser-induced fluorescence (LIF) of water vapour was investigated for its potential as a spatially resolved gasdynamic diagnostic. A cw diode laser operating near 1392 nm was scanned across a single absorption transition in the ngr1 + ngr3 band of H2O in a static cell, and the resulting fluorescence signal was collected near 2.7 µm (both ngr1 and ngr3 bands). Experiments were conducted at low pressure in pure water vapour and mixtures of water vapour and N2 using a 20 mW laser in a double-pass arrangement. A simple analytical model was developed to relate LIF intensity to gas properties as a function of laser power. The spectrally resolved, single-line excitation spectrum was fitted with a Voigt profile, allowing inference of the water vapour temperature from the Doppler-broadened component of the measured fluorescence lineshape. A two-line excitation scheme was also investigated as a means of measuring temperature with reduced measurement time. From these initial measurements, we estimate that a practical sensor for atmospheric pressure applications would require a minimum of 1-2 W of laser power for two-line, fixed-wavelength temperature measurements and a minimum of about 70 W of power for scanned-wavelength measurements.

  12. Anterior capsulotomy with an ultrashort-pulse laser.

    PubMed

    Tackman, Ramon Naranjo; Kuri, Jorge Villar; Nichamin, Louis D Skip; Edwards, Keith

    2011-05-01

    To assess the precision of laser anterior capsulotomy compared with that of manual continuous curvilinear capsulorhexis (CCC). Asociación Para Evitar La Ceguera en México IAP, Hospital Dr. Luis Sánchez Bulnes, Mexico City, Mexico. Nonrandomized single-center clinical trial. In patients presenting for cataract surgery, the LensAR Laser System was used to create a laser anterior capsulotomy of the surgeon's desired size. Capsule buttons were retrieved and measured and then compared with buttons retrieved from eyes having a manually torn CCC. Deviation from the intended diameter and the regularity of shape were assessed. When removing the capsule buttons at the start of surgery, the surgeon rated the ease of removal on a scale of 1 to 10 (1 = required manual capsulorhexis around the whole diameter; 10 = button free floating or required no manual detachment from remaining capsule during removal). The mean deviation from the intended diameter was 0.16 mm ± 0.17 (SD) for laser anterior capsulotomy and 0.42 ± 0.54 mm for CCC (P=.03). The mean absolute deviation from the intended diameter was 0.20 ± 0.12 mm and 0.49 ± 0.47 mm, respectively (P=.003). The mean of the average squared residuals was 0.01 ± 0.03 and 0.02 ± 0.04, respectively (P=.09). The median rating of the ease of removal was 9 (range 5 to 10). Laser anterior capsulotomy created a more precise capsule opening than CCC, and the buttons created by the laser procedure were easy to remove at the beginning of cataract surgery. Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  13. A plasma microlens for ultrashort high power lasers

    NASA Astrophysics Data System (ADS)

    Katzir, Yiftach; Eisenmann, Shmuel; Ferber, Yair; Zigler, Arie; Hubbard, Richard F.

    2009-07-01

    We present a technique for generation of miniature plasma lens system that can be used for focusing and collimating a high intensity femtosecond laser pulse. The plasma lens was created by a nanosecond laser, which ablated a capillary entrance. The spatial configuration of the ablated plasma focused a high intensity femtosecond laser pulse. This configuration offers versatility in the plasma lens small f-number for extremely tight focusing of high power lasers with no damage threshold restrictions of regular optical components.

  14. Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro.

    PubMed

    Babayan, Nelly; Hovhannisyan, Galina; Grigoryan, Bagrat; Grigoryan, Ruzanna; Sarkisyan, Natalia; Tsakanova, Gohar; Haroutiunian, Samvel; Aroutiounian, Rouben

    2017-11-01

    Laser-generated electron beams are distinguished from conventional accelerated particles by ultrashort beam pulses in the femtoseconds to picoseconds duration range, and their application may elucidate primary radiobiological effects. The aim of the present study was to determine the dose-rate effect of laser-generated ultrashort pulses of 4 MeV electron beam radiation on DNA damage and repair in human cells. The dose rate was increased via changing the pulse repetition frequency, without increasing the electron energy. The human chronic myeloid leukemia K-562 cell line was used to estimate the DNA damage and repair after irradiation, via the comet assay. A distribution analysis of the DNA damage was performed. The same mean level of initial DNA damages was observed at low (3.6 Gy/min) and high (36 Gy/min) dose-rate irradiation. In the case of low-dose-rate irradiation, the detected DNA damages were completely repairable, whereas the high-dose-rate irradiation demonstrated a lower level of reparability. The distribution analysis of initial DNA damages after high-dose-rate irradiation revealed a shift towards higher amounts of damage and a broadening in distribution. Thus, increasing the dose rate via changing the pulse frequency of ultrafast electrons leads to an increase in the complexity of DNA damages, with a consequent decrease in their reparability. Since the application of an ultrashort pulsed electron beam permits us to describe the primary radiobiological effects, it can be assumed that the observed dose-rate effect on DNA damage/repair is mainly caused by primary lesions appearing at the moment of irradiation. © The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

  15. Biodegradable microsphere-mediated cell perforation in microfluidic channel using femtosecond laser

    NASA Astrophysics Data System (ADS)

    Ishii, Atsuhiro; Ariyasu, Kazumasa; Mitsuhashi, Tatsuki; Heinemann, Dag; Heisterkamp, Alexander; Terakawa, Mitsuhiro

    2016-05-01

    The use of small particles has expanded the capability of ultrashort pulsed laser optoinjection technology toward simultaneous treatment of multiple cells. The microfluidic platform is one of the attractive systems that has obtained synergy with laser-based technology for cell manipulation, including optoinjection. We have demonstrated the delivery of molecules into suspended-flowing cells in a microfluidic channel by using biodegradable polymer microspheres and a near-infrared femtosecond laser pulse. The use of polylactic-co-glycolic acid microspheres realized not only a higher optoinjection ratio compared to that with polylactic acid microspheres but also avoids optical damage to the microfluidic chip, which is attributable to its higher optical intensity enhancement at the localized spot under a microsphere. Interestingly, optoinjection ratios to nucleus showed a difference for adhered cells and suspended cells. The use of biodegradable polymer microspheres provides high throughput optoinjection; i.e., multiple cells can be treated in a short time, which is promising for various applications in cell analysis, drug delivery, and ex vivo gene transfection to bone marrow cells and stem cells without concerns about residual microspheres.

  16. Ultrashort electron pulses as a four-dimensional diagnosis of plasma dynamics.

    PubMed

    Zhu, P F; Zhang, Z C; Chen, L; Li, R Z; Li, J J; Wang, X; Cao, J M; Sheng, Z M; Zhang, J

    2010-10-01

    We report an ultrafast electron imaging system for real-time examination of ultrafast plasma dynamics in four dimensions. It consists of a femtosecond pulsed electron gun and a two-dimensional single electron detector. The device has an unprecedented capability of acquiring a high-quality shadowgraph image with a single ultrashort electron pulse, thus permitting the measurement of irreversible processes using a single-shot scheme. In a prototype experiment of laser-induced plasma of a metal target under moderate pump intensity, we demonstrated its unique capability of acquiring high-quality shadowgraph images on a micron scale with a-few-picosecond time resolution.

  17. Investigation of SOI Raman Lasers for Mid-Infrared Gas Sensing

    PubMed Central

    Passaro, Vittorio M.N.; De Leonardis, Francesco

    2009-01-01

    In this paper, the investigation and detailed modeling of a cascaded Raman laser, operating in the midwave infrared region, is described. The device is based on silicon-on-insulator optical waveguides and a coupled resonant microcavity. Theoretical results are compared with recent experiments, demonstrating a very good agreement. Design criteria are derived for cascaded Raman lasers working as continuous wave light sources to simultaneously sense two types of gases, namely C2H6 and CO2, at a moderate power level of 130 mW. PMID:22408481

  18. Infrared Laser System for Extended Area Monitoring of Air Pollution

    NASA Technical Reports Server (NTRS)

    Snowman, L. R.; Gillmeister, R. J.

    1971-01-01

    An atmospheric pollution monitoring system using a spectrally scanning laser has been developed by the General Electric Company. This paper will report on an evaluation of a breadboard model, and will discuss applications of the concept to various ambient air monitoring situations. The system is adaptable to other tunable lasers. Operating in the middle infrared region, the system uses retroreflectors to measure average concentrations over long paths at low, safe power levels. The concept shows promise of meeting operational needs in ambient air monitoring and providing new data for atmospheric research.

  19. Scaling of an Optically Pumped Mid-Infrared Rubidium Laser

    DTIC Science & Technology

    2015-03-26

    v AFIT-ENP-MS-15-M-104 Abstract An optically pumped mid-infrared rubidium (Rb) pulsed laser has been demonstrated in a heat pipe ... Heat Pipe Assembly ........................................................................................12 Figure 3.3. Rb Number Density vs. Heat ...the first experiments that used a heat pipe as the gain cell. This experiment would influence the work of Sharma (Sharma, 1981:210). 9 Krupke

  20. Applications of infrared free electron lasers in picosecond and nonlinear spectroscopy

    NASA Astrophysics Data System (ADS)

    Fann, W. S.; Benson, S. V.; Madey, J. M. J.; Etemad, S.; Baker, G. L.; Rothberg, L.; Roberson, M.; Austin, R. H.

    1990-10-01

    In this paper we describe two different types of spectroscopic experiments that exploit the characteristics of the infrared FEL, Mark III, for studies of condensed matter: - the spectrum of χ(3)(-3ω; ω, ω, ω) in polyacetylene: an application of the free electron laser in nonlinear optical spectroscopy, and - a dynamical test of Davydov-like solitons in acetanilide using a picosecond free electron laser. These two studies highlight the unique contributions FELs can make to condensed-matter spectroscopy.

  1. Resonant infrared matrix-assisted pulsed laser evaporation of TiO2 nanoparticle films

    NASA Astrophysics Data System (ADS)

    Mayo, Daniel C.; Paul, Omari; Airuoyo, Idemudia J.; Pan, Zhengda; Schriver, Kenneth E.; Avanesyan, Sergey M.; Park, Hee K.; Mu, Richard R.; Haglund, Richard F.

    2013-03-01

    The successful development of flexible, high performance thin films that are competitive with silicon-based technology will likely require fabricating films of hybrid materials that incorporate nanomaterials, glasses, ceramics, polymers, and thin films. Resonant infrared matrix-assisted pulsed laser evaporation (RIR-MAPLE) is an ideal method for depositing organic materials and nanoparticles with minimal photochemical or photothermal damage to the deposited material. Furthermore, there are many nonhazardous solvents containing chemical functional groups with infrared absorption bands that are accessible using IR lasers. We report here results of recent work in which RIR-MAPLE has been employed successfully to deposit thin films of TiO2 nanoparticles on Si substrates. Using an Er:YAG laser ( λ=2.94 μm), we investigated a variety of MAPLE matrices containing -OH moieties, including water and all four isomers of butyl alcohol. The alcohol isomers are shown to provide effective and relatively nontoxic solvents for use in the RIR-MAPLE process. In addition, we examine the effects of varying concentration and laser fluence on film roughness and surface coverage.

  2. Passive and active mid-infrared semiconductor nanostructures: Three-dimensional metamaterials and high wall plug efficiency quantum cascade lasers

    NASA Astrophysics Data System (ADS)

    Hoffman, Anthony J.

    Every instant, light and matter are interacting in ways that shape the world around us. This dissertation examines the interaction of mid-infrared light with stacks of thin semiconductor layers. The work is divided into two parts: mid-infrared metamaterials and high wall plug efficiency (WPE) Quantum Cascade (QC) lasers. The mid-infrared metamaterials represent an entirely new class of material and have great potential for enabling highly-desired applications such as sub-diffraction imaging, confinement, and waveguiding. High WPE QC lasers greatly enhance the commercial feasibility of sensing, infrared countermeasures and free-space infrared communications. The first part of this dissertation describes the first three-dimensional, optical metamaterial. The all-semiconductor metamaterial is based on a strongly anisotropic dielectric function and exhibits negative refraction for a large bandwidth in the mid-infrared. The underlying theory of strongly anisotropic metamaterials is discussed, detailed characterization of several metamaterials is presented, and a macroscopic beam experiment is employed to demonstrate negative refraction. A detailed study of waveguides with strongly anisotropic cores is also presented and the low-order mode cutoff for such left-handed waveguides is observed. The second part of this dissertation discusses improvements in QC laser WPE through improved processing, packaging, and design. Devices using conventional QC design strategies processed as buried heterostructures operate with 5% WPE at room temperature in continuous wave mode, a significant improvement over previous generation devices. To further improve WPE, QC lasers based on ultra-strong coupling between the injector and upper-laser levels are designed and characterized. These devices operate with nearly 50% pulsed WPE---a true milestone for QC technology. A new type of QC laser design incorporating heterogeneous injector regions to reduce the voltage defect and thus improve WPE is

  3. Molecular dispersion spectroscopy for chemical sensing using chirped mid-infrared quantum cascade laser.

    PubMed

    Wysocki, Gerard; Weidmann, Damien

    2010-12-06

    A spectroscopic method of molecular detection based on dispersion measurements using a frequency-chirped laser source is presented. An infrared quantum cascade laser emitting around 1912 cm(-1) is used as a tunable spectroscopic source to measure dispersion that occurs in the vicinity of molecular ro-vibrational transitions. The sample under study is a mixture of nitric oxide in dry nitrogen. Two experimental configurations based on a coherent detection scheme are investigated and discussed. The theoretical models, which describe the observed spectral signals, are developed and verified experimentally. The method is particularly relevant to optical sensing based on mid-infrared quantum cascade lasers as the high chirp rates available with those sources can significantly enhance the magnitude of the measured dispersion signals. The method relies on heterodyne beatnote frequency measurements and shows high immunity to variations in the optical power received by the photodetector.

  4. Black phosphorus saturable absorber for ultrashort pulse generation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sotor, J., E-mail: jaroslaw.sotor@pwr.edu.pl; Sobon, G.; Abramski, K. M.

    Low-dimensional materials, due to their unique and versatile properties, are very interesting for numerous applications in electronics and optoelectronics. Recently rediscovered black phosphorus, with a graphite-like layered structure, can be effectively exfoliated up to the single atomic layer called phosphorene. Contrary to graphene, it possesses a direct band gap controllable by the number of stacked atomic layers. For those reasons, black phosphorus is now intensively investigated and can complement or replace graphene in various photonics and electronics applications. Here, we demonstrate that black phosphorus can serve as a broadband saturable absorber and can be used for ultrashort optical pulse generation.more » The mechanically exfoliated ∼300 nm thick layers of black phosphorus were transferred onto the fiber core, and under pulsed excitation at 1560 nm wavelength, its transmission increases by 4.6%. We have demonstrated that the saturable absorption of black phosphorus is polarization sensitive. The fabricated device was used to mode-lock an Er-doped fiber laser. The generated optical solitons with the 10.2 nm bandwidth and 272 fs duration were centered at 1550 nm. The obtained results unambiguously show that black phosphorus can be effectively used for ultrashort pulse generation with performances similar or even better than currently used graphene or carbon nanotubes. This application of black phosphorus proves its great potential to future practical use in photonics.« less

  5. Vapor-phase infrared laser spectroscopy: from gas sensing to forensic urinalysis.

    PubMed

    Bartlome, Richard; Rey, Julien M; Sigrist, Markus W

    2008-07-15

    Numerous gas-sensing devices are based on infrared laser spectroscopy. In this paper, the technique is further developed and, for the first time, applied to forensic urinalysis. For this purpose, a difference frequency generation laser was coupled to an in-house-built, high-temperature multipass cell (HTMC). The continuous tuning range of the laser was extended to 329 cm(-1) in the fingerprint C-H stretching region between 3 and 4 microm. The HTMC is a long-path absorption cell designed to withstand organic samples in the vapor phase (Bartlome, R.; Baer, M.; Sigrist, M. W. Rev. Sci. Instrum. 2007, 78, 013110). Quantitative measurements were taken on pure ephedrine and pseudoephedrine vapors. Despite featuring similarities, the vapor-phase infrared spectra of these diastereoisomers are clearly distinguishable with respect to a vibrational band centered at 2970.5 and 2980.1 cm(-1), respectively. Ephedrine-positive and pseudoephedrine-positive urine samples were prepared by means of liquid-liquid extraction and directly evaporated in the HTMC without any preliminary chromatographic separation. When 10 or 20 mL of ephedrine-positive human urine is prepared, the detection limit of ephedrine, prohibited in sports as of 10 microg/mL, is 50 or 25 microg/mL, respectively. The laser spectrometer has room for much improvement; its potential is discussed with respect to doping agents detection.

  6. Dual beam photoacoustic infrared spectroscopy of solids using an external cavity quantum cascade laser.

    PubMed

    Dehghany, M; Michaelian, K H

    2012-06-01

    Quantum cascade laser-based instrumentation for dual beam photoacoustic (PA) spectroscopy is described in this article. Experimental equipment includes a 4.55 μm (2141-2265 cm(-1)) continuous wave external cavity quantum cascade laser (EC-QCL), two gas-microphone PA cells, and two lock-in amplifiers. Correction for the time and wavenumber dependence of the laser output is effected through real-time division of the PA signals derived from the sample and reference channels. Source-compensated mid-infrared absorption spectra of carbon black powder and aromatic hydrocarbon solids were obtained to confirm the reliability of the method. Absorption maxima in the EC-QCL PA spectra of hydrocarbons are better defined than those in Fourier transform infrared spectra acquired under similar conditions, enabling the detection of several previously unknown bands.

  7. Review on short-wavelength infrared laser gated-viewing at Fraunhofer IOSB

    NASA Astrophysics Data System (ADS)

    Göhler, Benjamin; Lutzmann, Peter

    2017-03-01

    This paper reviews the work that has been done at Fraunhofer IOSB (and its predecessor institutes) in the past ten years in the area of laser gated-viewing (GV) in the short-wavelength infrared (SWIR) band. Experimental system demonstrators in various configurations have been built up to show the potential for different applications and to investigate specific topics. The wavelength of the pulsed illumination laser is 1.57 μm and lies in the invisible, retina-safe region allowing much higher pulse energies than for wavelengths in the visible or near-infrared band concerning eye safety. All systems built up, consist of gated Intevac LIVAR® cameras based on EBCCD/EBCMOS detectors sensitive in the SWIR band. This review comprises military and civilian applications in maritime and land domain-in particular vision enhancement in bad visibility, long-range applications, silhouette imaging, 3-D imaging by sliding gates and slope method, bistatic GV imaging, and looking through windows. In addition, theoretical studies that were conducted-e.g., estimating 3-D accuracy or modeling range performance-are presented. Finally, an outlook for future work in the area of SWIR laser GV at Fraunhofer IOSB is given.

  8. Infrared and laser-Raman spectroscopic studies of thermally-induced globular protein gels.

    PubMed

    Clark, A H; Saunderson, D H; Suggett, A

    1981-03-01

    Infrared and laser-Raman spectroscopy have been used to follow secondary structure changes during the heat-set gelation of a number of aqueous (D2O) globular protein solutions. Measurements of the infrared Amide I' absorption band around 1650 cm-1, for BSA gels of varying clarity and texture, have shown that the very considerable variations in network structure underlying these materials are not reflected in obvious differences in secondary structure. In all cases aggregation is accompanied by development of beta-sheet of a kind common in fibrous protein systems, but for BSA at least this does not appear to vary significantly in amount from one gel type to another. Infrared studies of gels formed from other protein systems have confirmed this tendency for beta-sheet to develop during aggregation, and the tendency is further substantiated by laser-Raman evidence which provides the extra information that in most of the examples studied alpha-helix content simultaneously falls. From these, and other observations, some generalisations are made about the thermally-induced sol-to-gel transformations of globular proteins.

  9. Near-infrared laser irradiation improves the development of mouse pre-implantation embryos.

    PubMed

    Yokoo, Masaki; Mori, Miho

    2017-05-27

    The aim of the present study was to assess the effects of near-infrared laser irradiation on the in vitro development of mouse embryos. Female ICR mice were superovulated with pregnant mare serum gonadotropin and human chorionic gonadotropin (hCG), and mated with male mice. Two-cell stage embryos were collected 40 h after administering hCG and cultured in M16 medium. Two-cell embryos (0 h after culture), 8-cell embryos (approx. 30 h after culture), morula (approx. 48 h after culture), and blastocysts (approx. 73 h after culture) were irradiated at 904 nm for 60 s. These embryos were cultured in a time-lapse monitoring system and the timing of blastocyst hatching was evaluated. Some of the irradiated blastocysts were transferred to the uterine horns of pseudopregnant recipients immediately after irradiation. Pregnancy rates, and offspring growth and fertility, were evaluated. Near-infrared laser irradiation increased the speed of in vitro mouse embryo development. In irradiated blastocysts, hatching was faster than in control (non-irradiated) blastocysts (18.4 vs. 28.2 h, P < 0.05). When 195 irradiated blastocysts were transferred to 18 pseudopregnant mice, all became pregnant and 92 (47.2%) normal-looking pups were born alive. When 182 control blastocysts were transferred to 17 pseudopregnant mice, 14 (82.4%) became pregnant and 54 (29.7%) normal-looking pups were born alive. The growth trajectories (up to 5 weeks) of offspring from irradiated blastocysts were similar to those from control blastocysts. Second generation offspring from transplanted animals were all fertile. These results indicate that near-infrared laser irradiation improves the quality of mouse embryo development in vitro, and increases the live birth rate without affecting the normality of the offspring. Thus, the near-infrared laser method may enhance the quality of embryos and contribute to improvements in reproductive technologies in mammals. Copyright © 2017 Elsevier Inc. All rights

  10. First light from the Diocles laser: Relativistic laser-plasmas and beams

    NASA Astrophysics Data System (ADS)

    Umstadter, Donald

    2007-06-01

    Reported are first experimental results from a new high-power (150 TW) laser, Diocles, now in operation at the University of Nebraska, Lincoln. Discussed are novel approaches to using the ultra-high-intensity light from this laser to study relativistic laser plasma interactions. Bright, ultrashort duration (femtosecond ) pulses of energetic (keV -- MeV) x-ray and charged-particle beams are generated through these interactions. Also covered in this talk will be applications of these unique radiation sources for research in the physical sciences, as well as biomedicine, defense and homeland security.

  11. [Laser exposure and noncoherent infrared therapy in the treatment of mandibular fractures].

    PubMed

    Deriabin, E I

    2001-01-01

    The efficiency of laser exposure and noncoherent infrared (IR) therapy in patients with mandibular fractures were compared. Non coherent IR exposure promoted a decrease in the number of inflammatory reactions and accelerated rehabilitation of patients.

  12. Hundred-watt-level high power random distributed feedback Raman fiber laser at 1150 nm and its application in mid-infrared laser generation.

    PubMed

    Zhang, Hanwei; Zhou, Pu; Wang, Xiong; Du, Xueyuan; Xiao, Hu; Xu, Xiaojun

    2015-06-29

    Two kinds of hundred-watt-level random distributed feedback Raman fiber have been demonstrated. The optical efficiency can reach to as high as 84.8%. The reported power and efficiency of the random laser is the highest one as we know. We have also demonstrated that the developed random laser can be further used to pump a Ho-doped fiber laser for mid-infrared laser generation. Finally, 23 W 2050 nm laser is achieved. The presented laser can obtain high power output efficiently and conveniently and opens a new direction for high power laser sources at designed wavelength.

  13. Ceramic Laser Materials

    PubMed Central

    Sanghera, Jasbinder; Kim, Woohong; Villalobos, Guillermo; Shaw, Brandon; Baker, Colin; Frantz, Jesse; Sadowski, Bryan; Aggarwal, Ishwar

    2012-01-01

    Ceramic laser materials have come a long way since the first demonstration of lasing in 1964. Improvements in powder synthesis and ceramic sintering as well as novel ideas have led to notable achievements. These include the first Nd:yttrium aluminum garnet (YAG) ceramic laser in 1995, breaking the 1 KW mark in 2002 and then the remarkable demonstration of more than 100 KW output power from a YAG ceramic laser system in 2009. Additional developments have included highly doped microchip lasers, ultrashort pulse lasers, novel materials such as sesquioxides, fluoride ceramic lasers, selenide ceramic lasers in the 2 to 3 μm region, composite ceramic lasers for better thermal management, and single crystal lasers derived from polycrystalline ceramics. This paper highlights some of these notable achievements. PMID:28817044

  14. Relativistically induced transparency acceleration of light ions by an ultrashort laser pulse interacting with a heavy-ion-plasma density gradient

    NASA Astrophysics Data System (ADS)

    Sahai, Aakash A.; Tsung, Frank S.; Tableman, Adam R.; Mori, Warren B.; Katsouleas, Thomas C.

    2013-10-01

    -540410.1007/3-540-47789-6_36 2331, 342 (2002)] simulations. We model the acceleration of protons to GeV energies with tens-of-femtoseconds laser pulses of a few petawatts. The scaling of proton energy with laser power compares favorably to other mechanisms for ultrashort pulses [Schreiber , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.97.045005 97, 045005 (2006); Esirkepov , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.92.175003 92, 175003 (2004); Silva , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.92.015002 92, 015002 (2004); Fiuza , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.109.215001 109, 215001 (2012)].

  15. Visible supercontinuum generation from a tunable mid-infrared laser

    NASA Astrophysics Data System (ADS)

    Marble, Christopher B.; O'Connor, Sean P.; Nodurft, Dawson T.; Yakovlev, Vladislav V.; Wharmby, Andrew W.

    2018-02-01

    Calcium fluoride, BK7 and fused silica are common optical materials used in lenses and windows. In this report, we discuss supercontinuum generation using tunable femtosecond mid-IR laser pulses with wavelengths ranging from 2.7 μm to 7.0 μm and pulse energies between 3 and 18 microjoules. We observed harmonic generation in fused silica and BK7, but not supercontinuum generation. Other borosilicate targets generated supercontinuum in both visible and near infrared regions of the spectrum. The visible supercontinuum was, in some instances, strong enough to be observed directly by the human eye. These results contribute to ongoing work being done to refine eye safety standards for femtosecond lasers.

  16. Direct inscription of Bragg gratings into coated fluoride fibers for widely tunable and robust mid-infrared lasers.

    PubMed

    Bharathan, Gayathri; Woodward, Robert I; Ams, Martin; Hudson, Darren D; Jackson, Stuart D; Fuerbach, Alex

    2017-11-27

    We report the development of a widely tunable all-fiber mid-infrared laser system based on a mechanically robust fiber Bragg grating (FBG) which was inscribed through the polymer coating of a Ho 3+ -Pr 3+ co-doped double clad ZBLAN fluoride fiber by focusing femtosecond laser pulses into the core of the fiber without the use of a phase mask. By applying mechanical tension and compression to the FBG while pumping the fiber with an 1150 nm laser diode, a continuous wave (CW) all-fiber laser with a tuning range of 37 nm, centered at 2870 nm, was demonstrated with up to 0.29 W output power. These results pave the way for the realization of compact and robust mid-infrared fiber laser systems for real-world applications in spectroscopy and medicine.

  17. Patterning of organic photovoltaic on R2R processed thin film barriers using IR laser sources

    NASA Astrophysics Data System (ADS)

    Fledderus, H.; Akkerman, H. B.; Salem, A.; Friedrich Schilling, N.; Klotzbach, U.

    2017-02-01

    We present the development of laser processes for flexible OPV on roll-to-roll (RR2R) produced thin film barrier with indium tin oxide (ITO) as transparent conductive (TC) bottom electrode. Direct laser structuring of ITO on such barrier films (so-called P1 process) is very challenging since the layers are all transparent, a complete electrical isolation is required, and the laser process should not influence the barrier performance underneath the scribes. Based on the optical properties off the SiN and ITTO, ultra-short pulse lasers inn picosecond and femtosecond regime with standard infrared (IR) wavelength as well as lasers with new a wavelength (22 μm regime) are tested for this purpose. To determine a process window for a specific laser a fixed methodology is adopted. Single pulse ablation tests were followed by scribing experiments where the pulse overlap was tuned by varying laser pulse fluence, writing speed and frequency. To verify that the laser scribing does not result inn barrier damage underneath, a new test method was developed based on the optical Ca-test. This method shows a clear improvement in damage analysis underneath laser scribes over normal optical inspection methods (e.g. microscope, optical profiler, SEM). This way clear process windows can be obtained for IR TC patterning.

  18. Surface Structuring with Polarization-Singular Femtosecond Laser Beams Generated by a q-plate

    PubMed Central

    Nivas, Jijil JJ; Cardano, Filippo; Song, Zhenming; Rubano, Andrea; Fittipaldi, Rosalba; Vecchione, Antonio; Paparo, Domenico; Marrucci, Lorenzo; Bruzzese, Riccardo; Amoruso, Salvatore

    2017-01-01

    In the last few years femtosecond optical vortex beams with different spatial distributions of the state of polarization (e.g. azimuthal, radial, spiral, etc.) have been used to generate complex, regular surface patterns on different materials. Here we present an experimental investigation on direct femtosecond laser surface structuring based on a larger class of vector beams generated by means of a q-plate with topological charge q = +1/2. In fact, voltage tuning of q-plate optical retardation allows generating a family of ultrashort laser beams with a continuous spatial evolution of polarization and fluence distribution in the focal plane. These beams can be thought of as a controlled coherent superposition of a Gaussian beam with uniform polarization and a vortex beam with a radial or azimuthal state of polarization. The use of this family of ultrashort laser beams in surface structuring leads to a further extension of the achievable surface patterns. The comparison of theoretical predictions of the vector beam characteristics at the focal plane and the generated surface patterns is used to rationalize the dependence of the surface structures on the local state of the laser beam, thus offering an effective way to either design unconventional surface structures or diagnose complex ultrashort laser beams. PMID:28169342

  19. Surface Structuring with Polarization-Singular Femtosecond Laser Beams Generated by a q-plate.

    PubMed

    Nivas, Jijil Jj; Cardano, Filippo; Song, Zhenming; Rubano, Andrea; Fittipaldi, Rosalba; Vecchione, Antonio; Paparo, Domenico; Marrucci, Lorenzo; Bruzzese, Riccardo; Amoruso, Salvatore

    2017-02-07

    In the last few years femtosecond optical vortex beams with different spatial distributions of the state of polarization (e.g. azimuthal, radial, spiral, etc.) have been used to generate complex, regular surface patterns on different materials. Here we present an experimental investigation on direct femtosecond laser surface structuring based on a larger class of vector beams generated by means of a q-plate with topological charge q = +1/2. In fact, voltage tuning of q-plate optical retardation allows generating a family of ultrashort laser beams with a continuous spatial evolution of polarization and fluence distribution in the focal plane. These beams can be thought of as a controlled coherent superposition of a Gaussian beam with uniform polarization and a vortex beam with a radial or azimuthal state of polarization. The use of this family of ultrashort laser beams in surface structuring leads to a further extension of the achievable surface patterns. The comparison of theoretical predictions of the vector beam characteristics at the focal plane and the generated surface patterns is used to rationalize the dependence of the surface structures on the local state of the laser beam, thus offering an effective way to either design unconventional surface structures or diagnose complex ultrashort laser beams.

  20. Surface Structuring with Polarization-Singular Femtosecond Laser Beams Generated by a q-plate

    NASA Astrophysics Data System (ADS)

    Nivas, Jijil Jj; Cardano, Filippo; Song, Zhenming; Rubano, Andrea; Fittipaldi, Rosalba; Vecchione, Antonio; Paparo, Domenico; Marrucci, Lorenzo; Bruzzese, Riccardo; Amoruso, Salvatore

    2017-02-01

    In the last few years femtosecond optical vortex beams with different spatial distributions of the state of polarization (e.g. azimuthal, radial, spiral, etc.) have been used to generate complex, regular surface patterns on different materials. Here we present an experimental investigation on direct femtosecond laser surface structuring based on a larger class of vector beams generated by means of a q-plate with topological charge q = +1/2. In fact, voltage tuning of q-plate optical retardation allows generating a family of ultrashort laser beams with a continuous spatial evolution of polarization and fluence distribution in the focal plane. These beams can be thought of as a controlled coherent superposition of a Gaussian beam with uniform polarization and a vortex beam with a radial or azimuthal state of polarization. The use of this family of ultrashort laser beams in surface structuring leads to a further extension of the achievable surface patterns. The comparison of theoretical predictions of the vector beam characteristics at the focal plane and the generated surface patterns is used to rationalize the dependence of the surface structures on the local state of the laser beam, thus offering an effective way to either design unconventional surface structures or diagnose complex ultrashort laser beams.

  1. Suppressing the memory state of floating gate transistors with repeated femtosecond laser backside irradiations

    NASA Astrophysics Data System (ADS)

    Chambonneau, Maxime; Souiki-Figuigui, Sarra; Chiquet, Philippe; Della Marca, Vincenzo; Postel-Pellerin, Jérémy; Canet, Pierre; Portal, Jean-Michel; Grojo, David

    2017-04-01

    We demonstrate that infrared femtosecond laser pulses with intensity above the two-photon ionization threshold of crystalline silicon induce charge transport through the tunnel oxide in floating gate Metal-Oxide-Semiconductor transistor devices. With repeated irradiations of Flash memory cells, we show how the laser-produced free-electrons naturally redistribute on both sides of the tunnel oxide until the electric field of the transistor is suppressed. This ability enables us to determine in a nondestructive, rapid and contactless way the flat band and the neutral threshold voltages of the tested device. The physical mechanisms including nonlinear ionization, quantum tunneling of free-carriers, and flattening of the band diagram are discussed for interpreting the experiments. The possibility to control the carriers in memory transistors with ultrashort pulses holds promises for fast and remote device analyses (reliability, security, and defectivity) and for considerable developments in the growing field of ultrafast microelectronics.

  2. Parallel processing of embossing dies with ultrafast lasers

    NASA Astrophysics Data System (ADS)

    Jarczynski, Manfred; Mitra, Thomas; Brüning, Stephan; Du, Keming; Jenke, Gerald

    2018-02-01

    Functionalization of surfaces equips products and components with new features like hydrophilic behavior, adjustable gloss level, light management properties, etc. Small feature sizes demand diffraction-limited spots and adapted fluence for different materials. Through the availability of high power fast repeating ultrashort pulsed lasers and efficient optical processing heads delivering diffraction-limited small spot size of around 10μm it is feasible to achieve fluences higher than an adequate patterning requires. Hence, parallel processing is becoming of interest to increase the throughput and allow mass production of micro machined surfaces. The first step on the roadmap of parallel processing for cylinder embossing dies was realized with an eight- spot processing head based on ns-fiber laser with passive optical beam splitting, individual spot switching by acousto optical modulation and an advanced imaging. Patterning of cylindrical embossing dies shows a high efficiency of nearby 80%, diffraction-limited and equally spaced spots with pitches down to 25μm achieved by a compression using cascaded prism arrays. Due to the nanoseconds laser pulses the ablation shows the typical surrounding material deposition of a hot process. In the next step the processing head was adapted to a picosecond-laser source and the 500W fiber laser was replaced by an ultrashort pulsed laser with 300W, 12ps and a repetition frequency of up to 6MHz. This paper presents details about the processing head design and the analysis of ablation rates and patterns on steel, copper and brass dies. Furthermore, it gives an outlook on scaling the parallel processing head from eight to 16 individually switched beamlets to increase processing throughput and optimized utilization of the available ultrashort pulsed laser energy.

  3. Optical trapping of nanoparticles by ultrashort laser pulses.

    PubMed

    Usman, Anwar; Chiang, Wei-Yi; Masuhara, Hiroshi

    2013-01-01

    Optical trapping with continuous-wave lasers has been a fascinating field in the optical manipulation. It has become a powerful tool for manipulating micrometer-sized objects, and has been widely applied in physics, chemistry, biology, material, and colloidal science. Replacing the continuous-wave- with pulsed-mode laser in optical trapping has already revealed some novel phenomena, including the stable trap, modifiable trapping positions, and controllable directional optical ejections of particles in nanometer scales. Due to two distinctive features; impulsive peak powers and relaxation time between consecutive pulses, the optical trapping with the laser pulses has been demonstrated to have some advantages over conventional continuous-wave lasers, particularly when the particles are within Rayleigh approximation. This would open unprecedented opportunities in both fundamental science and application. This Review summarizes recent advances in the optical trapping with laser pulses and discusses the electromagnetic formulations and physical interpretations of the new phenomena. Its aim is rather to show how beautiful and promising this field will be, and to encourage the in-depth study of this field.

  4. Following coherent multichannel nuclear wave packets in pump-probe studies of O2 with ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Xue, Shan; Du, Hongchuan; Hu, Bitao; Lin, C. D.; Le, Anh-Thu

    2018-04-01

    We reexamine the recent pump-probe experiment with O2 using short intense infrared laser pulses theoretically. Using parameters that closely mimic the experimental conditions and taking into account the angle-dependent population redistribution due to resonant coupling between the relevant states, we show that the observed kinetic energy release spectra, including the energy-dependent structure and the quantum beat frequencies, can be accurately reproduced. Our results reveal additional important channels that were missed earlier. In particular, the strong contributions from O2+a 4Πu and b 4Σg- states lead to the possibility of observing the interchannel beating. We further demonstrate that, by varying the laser parameters, the coherent nuclear wave-packet motions on different potential energy surfaces (PESs) can be probed and the properties of the PES can be examined. Future experiments with different wavelength lasers are proposed for better probing and controlling nuclear dynamics on different PESs.

  5. Physical mechanisms of SiN{sub x} layer structuring with ultrafast lasers by direct and confined laser ablation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rapp, S., E-mail: rapp@hm.edu; Erlangen Graduate School in Advanced Optical Technologies; Heinrich, G.

    2015-03-14

    In the production process of silicon microelectronic devices and high efficiency silicon solar cells, local contact openings in thin dielectric layers are required. Instead of photolithography, these openings can be selectively structured with ultra-short laser pulses by confined laser ablation in a fast and efficient lift off production step. Thereby, the ultrafast laser pulse is transmitted by the dielectric layer and absorbed at the substrate surface leading to a selective layer removal in the nanosecond time domain. Thermal damage in the substrate due to absorption is an unwanted side effect. The aim of this work is to obtain a deepermore » understanding of the physical laser-material interaction with the goal of finding a damage-free ablation mechanism. For this, thin silicon nitride (SiN{sub x}) layers on planar silicon (Si) wafers are processed with infrared fs-laser pulses. Two ablation types can be distinguished: The known confined ablation at fluences below 300 mJ/cm{sup 2} and a combined partial confined and partial direct ablation at higher fluences. The partial direct ablation process is caused by nonlinear absorption in the SiN{sub x} layer in the center of the applied Gaussian shaped laser pulses. Pump-probe investigations of the central area show ultra-fast reflectivity changes typical for direct laser ablation. Transmission electron microscopy results demonstrate that the Si surface under the remaining SiN{sub x} island is not damaged by the laser ablation process. At optimized process parameters, the method of direct laser ablation could be a good candidate for damage-free selective structuring of dielectric layers on absorbing substrates.« less

  6. FIBER AND INTEGRATED OPTICS: Compact fiber-optic compressor of ultrashort pulses

    NASA Astrophysics Data System (ADS)

    Nikitin, S. P.; Onishchukov, G. I.; Fomichev, A. A.

    1992-02-01

    A theoretical design of a universal compact fiber-optic compressor based on a monochromator with a spherical mirror in the plane of its exit slit was considered. Ultrashort pulses emitted by an actively mode-locked YAG:Nd3+ laser, whose spectrum was broadened in a fiber-optic waveguide, were compressed experimentally to 2.7 ns. A universal compact compressor was developed: it produced 4-ns pulses with an average radiation power of about 1 W. The dimensions of this compressor were several times smaller than those of a traditional scheme using a diffraction grating to compress pulses having an initial duration of about 100 ns.

  7. Influence of laser pulse duration on the electrochemical performance of laser structured LiFePO4 composite electrodes

    NASA Astrophysics Data System (ADS)

    Mangang, M.; Seifert, H. J.; Pfleging, W.

    2016-02-01

    Lithium iron phosphate is a promising cathode material for lithium-ion batteries, despite its low electrical conductivity and lithium-ion diffusion kinetic. To overcome the reduced rate performance, three dimensional (3D) architectures were generated in composite cathode layers. By using ultrashort laser radiation with pulse durations in the femtosecond regime the ablation depth per pulse is three times higher compared to nanosecond laser pulses. Due to the 3D structuring, the surface area of the active material which is in direct contact with liquid electrolyte, i.e. the active surface, is increased. As a result the capacity retention and the cycle stability were significantly improved, especially for high charging/discharging currents. Furthermore, a 3D structure leads to higher currents during cyclic voltammetry. Thus, the lithium-ion diffusion kinetic in the cell was improved. In addition, using ultrashort laser pulses results in a high aspect ratio and further improvement of the cell kinetic was achieved.

  8. Programmable, secondary frequency standard based infrared synthesizer using tunable lead-salt diode lasers

    NASA Technical Reports Server (NTRS)

    Freed, C.; Bielinski, J. W.; Lo, W.

    1983-01-01

    Quantum phase noise limited Lorentzian power spectral densities were achieved with tunable lead-salt diode lasers. Linewidths as narrow as 22 kHz were observed. A truly programmable infrared synthesizer was produced by frequency-offset-locking the tunable diode lasers to the combination of a stable CO2 (or CO) reference laser and a programmable microwave frequency synthesizer. Absolute frequency accuracy and reproducibility of about + or - 30 kHz (0.000001 kaysers) relative to the primary Cs frequency standard may now be obtained with this technique.

  9. Microprocessing of human hard tooth tissues surface by mid-infrared erbium lasers radiation

    NASA Astrophysics Data System (ADS)

    Belikov, Andrey V.; Shatilova, Ksenia V.; Skrypnik, Alexei V.

    2015-03-01

    A new method of hard tooth tissues laser treatment is described. The method consists in formation of regular microdefects on tissue surface by mid-infrared erbium laser radiation with propagation ratio M2<2 (Er-laser microprocessing). Proposed method was used for preparation of hard tooth tissues surface before filling for improvement of bond strength between tissues surface and restorative materials, microleakage reduction between tissues surface and restorative materials, and for caries prevention as a result of increasing microhardness and acid resistance of tooth enamel.

  10. Numerical investigation on high power mid-infrared supercontinuum fiber lasers pumped at 3 µm.

    PubMed

    Wei, Chen; Zhu, Xiushan; Norwood, Robert A; Song, Feng; Peyghambarian, N

    2013-12-02

    High power mid-infrared (mid-IR) supercontinuum (SC) laser sources in the 3-12 µm region are of great interest for a variety of applications in many fields. Although various mid-IR SC laser sources have been proposed and investigated experimentally and theoretically in the past several years, power scaling of mid-IR SC lasers beyond 3 μm with infrared edges extending beyond 7 μm are still challenges because the wavelengths of most previously used pump sources are below 2 μm. These problems can be solved with the recent development of mode-locked fiber lasers at 3 μm. In this paper, high power mid-IR SC laser sources based on dispersion engineered tellurite and chalcogenide fibers and pumped by ultrafast lasers at 3 µm are proposed and investigated. Our simulation results show that, when a W-type tellurite fiber with a zero dispersion wavelength (ZDW) of 2.7 µm is pumped at 2.78 μm, the power proportion of the SC laser beyond 3 µm can exceed 40% and the attainable SC output power of the proposed solid-cladding tellurite fiber is one order of magnitude higher than that of existing microstructured tellurite fibers. Our calculation also predicts that a very promising super-broadband mid-IR SC fiber laser source covering two atmospheric windows and molecules' "fingerprint" region can be obtained with a microstructured As2Se3 chalcogenide fiber pumped at 2.78 μm.

  11. Studying the mechanism of neurostimulation by infrared laser light using GCaMP6s and Rhodamine B imaging

    NASA Astrophysics Data System (ADS)

    Moreau, David; Lefort, Claire; Bardet, Sylvia M.; O'Connor, Rodney P.

    2016-03-01

    Infrared laser light radiation can be used to depolarize neurons and to stimulate neural activity. The absorption of infrared radiation and heating of biological tissue is thought to be the underlying mechanism of this phenomenon whereby local temperature increases in the plasma membrane of cells either directly influence membrane properties or act via temperature sensitive ion channels. Action potentials are typically measured electrically in neurons with microelectrodes, but they can also be observed using fluorescence microscopy techniques that use synthetic or genetically encoded calcium indicators. In this work, we studied the impact of infrared laser light on neuronal calcium signals to address the mechanism of these thermal effects. Cultured primary mouse hippocampal neurons expressing the genetically encoded calcium indicator GCaMP6s were used in combination with the temperature sensitive fluorophore Rhodamine B to measure calcium signals and temperature changes at the cellular level. Here we present our all-optical strategy for studying the influence of infrared laser light on neuronal activity.

  12. Effects of Infrared Laser Radiation on the In Vitro Isomerization of All-Trans Retinal to 11-Cis Retinal

    PubMed Central

    Liegner, J.; Taboada, J.; Tsin, A. T. C.

    2015-01-01

    The in vitro effect of infrared laser light on the isomerization of all-trans retinal dissolved in an ether/hexane and also an ethanol solvent was studied. Pulsed laser energy at 1064 nm was used to drive the molecular reconfiguration of all-trans retinal to 11-cis retinal. High pressure liquid chromatography (HPLC) was used to quantify the conversion. Overall isomerization was minimal (0.2 percent to 1.0 percent), yet, a significant difference in isomerization due to pulsed infrared laser energy over non-modulated monochromatic laser light was detected (up to 168 percent difference). Potentially, pulsed laser radiation tuned to the ethylenic stretch frequency of the C11=C12 bond of retinal may induce rotational changes to the chromophore. PMID:26321787

  13. Towards highest peak intensities for ultra-short MeV-range ion bunches

    NASA Astrophysics Data System (ADS)

    Busold, Simon; Schumacher, Dennis; Brabetz, Christian; Jahn, Diana; Kroll, Florian; Deppert, Oliver; Schramm, Ulrich; Cowan, Thomas E.; Blažević, Abel; Bagnoud, Vincent; Roth, Markus

    2015-07-01

    A laser-driven, multi-MeV-range ion beamline has been installed at the GSI Helmholtz center for heavy ion research. The high-power laser PHELIX drives the very short (picosecond) ion acceleration on μm scale, with energies ranging up to 28.4 MeV for protons in a continuous spectrum. The necessary beam shaping behind the source is accomplished by applying magnetic ion lenses like solenoids and quadrupoles and a radiofrequency cavity. Based on the unique beam properties from the laser-driven source, high-current single bunches could be produced and characterized in a recent experiment: At a central energy of 7.8 MeV, up to 5 × 108 protons could be re-focused in time to a FWHM bunch length of τ = (462 ± 40) ps via phase focusing. The bunches show a moderate energy spread between 10% and 15% (ΔE/E0 at FWHM) and are available at 6 m distance to the source und thus separated from the harsh laser-matter interaction environment. These successful experiments represent the basis for developing novel laser-driven ion beamlines and accessing highest peak intensities for ultra-short MeV-range ion bunches.

  14. Towards highest peak intensities for ultra-short MeV-range ion bunches

    PubMed Central

    Busold, Simon; Schumacher, Dennis; Brabetz, Christian; Jahn, Diana; Kroll, Florian; Deppert, Oliver; Schramm, Ulrich; Cowan, Thomas E.; Blažević, Abel; Bagnoud, Vincent; Roth, Markus

    2015-01-01

    A laser-driven, multi-MeV-range ion beamline has been installed at the GSI Helmholtz center for heavy ion research. The high-power laser PHELIX drives the very short (picosecond) ion acceleration on μm scale, with energies ranging up to 28.4 MeV for protons in a continuous spectrum. The necessary beam shaping behind the source is accomplished by applying magnetic ion lenses like solenoids and quadrupoles and a radiofrequency cavity. Based on the unique beam properties from the laser-driven source, high-current single bunches could be produced and characterized in a recent experiment: At a central energy of 7.8 MeV, up to 5 × 108 protons could be re-focused in time to a FWHM bunch length of τ = (462 ± 40) ps via phase focusing. The bunches show a moderate energy spread between 10% and 15% (ΔE/E0 at FWHM) and are available at 6 m distance to the source und thus separated from the harsh laser-matter interaction environment. These successful experiments represent the basis for developing novel laser-driven ion beamlines and accessing highest peak intensities for ultra-short MeV-range ion bunches. PMID:26212024

  15. Dispersion of near-infrared laser energy through radicular dentine when using plain or conical tips.

    PubMed

    Teo, Christine Yi Jia; George, Roy; Walsh, Laurence J

    2018-02-01

    The aim of this study was to investigate the influence of tip design on patterns of laser energy dispersion through the dentine of tooth roots when using near-infrared diode lasers. Diode laser emissions of 810 or 940 nm were used in combination with optical fiber tips with either conventional plain ends or conical ends, to irradiate tooth roots of oval or round cross-sectional shapes. The lasers were operated in continuous wave mode at 0.5 W for 5 s with the distal end of the fiber tip placed in the apical or coronal third of the root canal at preset positions. Laser light exiting through the roots and apical foramen was imaged, and the extent of lateral spread calculated. There was a significant difference in infrared light exiting the root canal apex between plain and conical fiber tips for both laser wavelengths, with more forward transmission of laser energy through the apex for plain tips. For both laser wavelengths, there were no significant differences in emission patterns when the variable of canal shape was used and all other variables were kept the same (plain vs conical tip, tip position). To ensure optimal treatment effect and to prevent the risks of inadvertent laser effects on the adjacent periapical tissues, it is important to have a good understanding of laser transmission characteristics of the root canal and root dentine. Importantly, it is also essential to understand transmission characteristics of plain and conical fibers tips.

  16. Infrared laser sealing of porcine vascular tissues using a 1,470 nm diode laser: Preliminary in vivo studies.

    PubMed

    Cilip, Christopher M; Kerr, Duane; Latimer, Cassandra A; Rosenbury, Sarah B; Giglio, Nicholas C; Hutchens, Thomas C; Nau, William H; Fried, Nathaniel M

    2017-04-01

    Infrared (IR) lasers are being explored as an alternative to radiofrequency (RF) and ultrasonic (US) devices for rapid hemostasis with minimal collateral zones of thermal damage and tissue necrosis. Previously, a 1,470 nm IR laser sealed and cut ex vivo porcine renal arteries of 1-8 mm diameter in 2 seconds, yielding burst pressures greater than 1,200 mmHg and thermal coagulation zones less than 3 mm. This preliminary study describes in vivo testing of a handheld laser probe in a porcine model. A handheld prototype with vessel/tissue clasping mechanism was tested on 73 blood vessels less than 6 mm diameter using 1,470 nm laser power of 35 W for 1-5 seconds. Device power settings, irradiation time, tissue type, vessel diameter, and histology sample number were recorded for each procedure. The probe was evaluated for hemostasis after sealing isolated and bundled arteriole/venous (A/V) vasculature of porcine abdomen and hind leg. Sealed vessel samples were collected for histological analysis of lateral thermal damage. Hemostasis was achieved in 57 of 73 seals (78%). The probe consistently sealed vasculature in small bowel mesentery, mesometrium, and gastrosplenic and epiploic regions. Seal performance was less consistent on hind leg vasculature including saphenous arteries/bundles and femoral and iliac arteries. Collagen denaturation averaged 1.6 ± 0.9 mm in eight samples excised for histologic examination. A handheld laser probe sealed porcine vessels, in vivo. Further probe development and laser parameter optimization is necessary before infrared lasers may be evaluated as an alternative to RF and US vessel sealing devices. Lasers Surg. Med. 49:366-371, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  17. Ultraviolet, visible, and infrared laser delivery using laser-to-fiber coupling via a grazing-incidence-based hollow taper

    NASA Astrophysics Data System (ADS)

    Ilev, Ilko K.; Waynant, Ronald W.

    2001-01-01

    We present a novel all-optical-waveguide method for ultraviolet (UV), visible (VIS) and infrared (IR) laser delivery including a lens-free method of laser-to-fiber coupling using a simple uncoated glass hollow taper. Based on the grazing incidence effect, the hollow taper provides a way of direct launching, without any intermediate focusing elements, high power laser radiation into delivery fibers. Because of the mutual action of the nearly parallel laser excitation, the mode coupling process, and mode filtering effect, the hollow taper serves as a mode converter that transforms the highly multimode profile of the input laser emission into a high-quality Gaussian-shaped profile at the taper output. When the grazing incidence effect of the taper is applied to laser delivery, the maintenance of high reflectance coefficients in a wide spectral region allows to utilize the same uncoated hollow taper for laser radiation in the UV, VIS and IR ranges. Applying the experimental hollow-taper based delivery systems, we obtain high laser- to-taper and taper-to-fiber coupling efficiencies.

  18. Guiding of laser pulses in plasma waveguides created by linearly-polarized femtosecond laser pulses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lemos, N.; Cardoso, L.; Geada, J.

    We experimentally demonstrate that plasma waveguides produced with ultra-short laser pulses (sub-picosecond) in gas jets are capable of guiding high intensity laser pulses. This scheme has the unique ability of guiding a high-intensity laser pulse in a plasma waveguide created by the same laser system in the very simple and stable experimental setup. A hot plasma column was created by a femtosecond class laser that expands into an on-axis parabolic low density profile suitable to act as a waveguide for high intensity laser beams. We have successfully guided ~10 15 W cm -2 laser pulses in a 8 mm longmore » hydrogen plasma waveguide with a 35% guiding efficiency.« less

  19. Guiding of laser pulses in plasma waveguides created by linearly-polarized femtosecond laser pulses

    DOE PAGES

    Lemos, N.; Cardoso, L.; Geada, J.; ...

    2018-02-16

    We experimentally demonstrate that plasma waveguides produced with ultra-short laser pulses (sub-picosecond) in gas jets are capable of guiding high intensity laser pulses. This scheme has the unique ability of guiding a high-intensity laser pulse in a plasma waveguide created by the same laser system in the very simple and stable experimental setup. A hot plasma column was created by a femtosecond class laser that expands into an on-axis parabolic low density profile suitable to act as a waveguide for high intensity laser beams. We have successfully guided ~10 15 W cm -2 laser pulses in a 8 mm longmore » hydrogen plasma waveguide with a 35% guiding efficiency.« less

  20. Non-invasive characterization and quality assurance of silicon micro-strip detectors using pulsed infrared laser

    NASA Astrophysics Data System (ADS)

    Ghosh, P.

    2016-01-01

    The Compressed Baryonic Matter (CBM) experiment at FAIR is composed of 8 tracking stations consisting of roughly 1300 double sided silicon micro-strip detectors of 3 different dimensions. For the quality assurance of prototype micro-strip detectors a non-invasive detector charaterization is developed. The test system is using a pulsed infrared laser for charge injection and characterization, called Laser Test System (LTS). The system is aimed to develop a set of characterization procedures which are non-invasive (non-destructive) in nature and could be used for quality assurances of several silicon micro-strip detectors in an efficient, reliable and reproducible way. The procedures developed (as reported here) uses the LTS to scan sensors with a pulsed infra-red laser driven by step motor to determine the charge sharing in-between strips and to measure qualitative uniformity of the sensor response over the whole active area. The prototype detector modules which are tested with the LTS so far have 1024 strips with a pitch of 58 μm on each side. They are read-out using a self-triggering prototype read-out electronic ASIC called n-XYTER. The LTS is designed to measure sensor response in an automatized procedure at several thousand positions across the sensor with focused infra-red laser light (spot size ≈ 12 μm, wavelength = 1060 nm). The pulse with a duration of ≈ 10 ns and power ≈ 5 mW of the laser pulse is selected such, that the absorption of the laser light in the 300 μm thick silicon sensor produces ≈ 24000 electrons, which is similar to the charge created by minimum ionizing particles (MIP) in these sensors. The laser scans different prototype sensors and various non-invasive techniques to determine characteristics of the detector modules for the quality assurance is reported.

  1. Air-guided photonic-crystal-fiber pulse-compression delivery of multimegawatt femtosecond laser output for nonlinear-optical imaging and neurosurgery

    NASA Astrophysics Data System (ADS)

    Lanin, Aleksandr A.; Fedotov, Il'ya V.; Sidorov-Biryukov, Dmitrii A.; Doronina-Amitonova, Lyubov V.; Ivashkina, Olga I.; Zots, Marina A.; Sun, Chi-Kuang; Ömer Ilday, F.; Fedotov, Andrei B.; Anokhin, Konstantin V.; Zheltikov, Aleksei M.

    2012-03-01

    Large-core hollow photonic-crystal fibers (PCFs) are shown to enable a fiber-format air-guided delivery of ultrashort infrared laser pulses for neurosurgery and nonlinear-optical imaging. With an appropriate dispersion precompensation, an anomalously dispersive 15-μm-core hollow PCF compresses 510-fs, 1070-nm light pulses to a pulse width of about 110 fs, providing a peak power in excess of 5 MW. The compressed PCF output is employed to induce a local photodisruption of corpus callosum tissues in mouse brain and is used to generate the third harmonic in brain tissues, which is captured by the PCF and delivered to a detector through the PCF cladding.

  2. Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves

    NASA Astrophysics Data System (ADS)

    Stahl, Charlotte S. D.; Tozburun, Serhat; Hutchens, Thomas C.; Lagoda, Gwen A.; Burnett, Arthur L.; Keller, Matthew D.; Fried, Nathaniel M.

    2013-03-01

    Optical nerve stimulation (ONS) is being explored for identification and preservation of the cavernous nerves (CN), responsible for erectile function, during prostate cancer surgery. This study compares three pulsed infrared lasers to determine whether differences in spectral linewidth and/or temporal pulse profile influence successful ONS of CN. Infrared laser radiation from the Capella diode laser (1873 nm, 5 ms, 10 Hz), Thulium fiber laser (TFL) (1873 nm, 5 ms, 10 Hz), and solid-state Holmium:YAG laser (2120 nm, 200 μs, 5 Hz) were transmitted through 400-μm-corediameter optical fibers, producing a 1-mm-diameter-spot on the nerve surface. Successful ONS was judged by an intracavernous pressure (ICP) response in the penis (n =10 rats) during a total stimulation time of 30 s. The narrow linewidth TFL (Δλ 0.5 nm) and broad linewidth Capella laser (Δλ 12 nm) performed similarly, producing ICP responses with a threshold radiant exposure of 0.45 J/cm2, and ICP response times of 12-17 s, while the Holmium laser stimulated at 0.59 J/cm2, and ICP response times of about 14-28 s. All three lasers demonstrated successful ONS of CN. ICP response time was dependent on the rate of energy deposition into the CN, rather than linewidth or temporal pulse profile.

  3. Perfluorocarbon compounds: transmitting liquids for infrared laser tissue ablation

    NASA Astrophysics Data System (ADS)

    Frenz, Martin; Pratisto, Hans S.; Toth, Cynthia A.; Jansen, E. Duco; Altermatt, Hans J.; Welch, Ashley J.; Weber, Heinz P.

    1996-05-01

    One concern during IR-laser ablation of tissue under water is the mechanical injury that may be induced in tissue due to rapid bubble expansion and collapse or due to strong laser-induced pressure waves. The objective of this study was to evaluate the feasibility of using a liquid which is transparent to the IR-region of the spectrum in order to minimize these undesired mechanical side-effects. As transmitting medium perfluorocarbon liquid was used. Free- running Er:YAG and Ho:YAG laser pulses were delivered into the liquid via a 400 micrometers fiber. Bubble formation during the ablation process was recorded with fast flash photography while pressure transients were measured with a needle hydrophone. The effect of the surrounding material (air, water, perfluorooctane) on the tissue response of chicken breast was evaluated in vitro using histology. It was observed that a large bubble (up to 6 mm in diameter) was formed under perfluorooctane driven by the ablation products. This bubble, however, does not generate a pressure wave when collapsing. Although perfluorooctane only shows a weak absorption for infrared radiation, laser-induced thermal lensing in the liquid strongly decreases the radiant exposure and therefore the ablation efficiency.

  4. Trans-cranial infrared laser stimulation induces hemodynamic and metabolic response measured by broadband near infrared spectroscopy in vivo on human forehead (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Wang, Xinlong; Nalawade, Sahil Sunil; Reddy, Divya Dhandapani; Tian, Fenghua; Gonzalez-Lima, F.; Liu, Hanli

    2017-02-01

    Transcranial infrared laser stimulation (TILS) uses infrared light (lasers or LEDs) for nondestructive and non-thermal photobiomodulation on the human brain. Although TILS has shown its beneficial effects to a variety of neurological and psychological conditions, its physiological mechanism remains unknown. Cytochrome-c-oxidase (CCO), the last enzyme in the electron transportation chain, is proposed to be the primary photoacceptor of this infrared laser. In this study, we wish to validate this proposed mechanism. We applied 8 minutes in vivo TILS on the right forehead of 11 human participants with a 1064-nm laser. Broad-band near infrared spectroscopy (bb-NIRS) from 740-900nm was also employed near the TILS site to monitor hemodynamic and metabolic responses during the stimulation and 5-minute recovery period. For rigorous comparison, we also performed similar 8-min bb-NIR measurements under placebo conditions. A multi-linear regression analysis based on the modified Beer-Lambert law was performed to estimate concentration changes of oxy-hemoglobin (Δ[HbO]), deoxy-hemoglobin (Δ[Hb]), and cytochrome-c-oxidase (Δ[CCO]). We found that TILS induced significant increases of [CCO], [HbO] and a decrease of [Hb] with dose-dependent manner as compared with placebo treatments. Furthermore, strong linear relationships or interplays between [CCO] versus [HbO] and [CCO] versus [Hb] induced by TILS were observed in vivo for the first time. These relationships have clearly revealed close coupling/relationship between the hemodynamic oxygen supply and blood volume versus up-regulation of CCO induced by photobiomodulation. Our results demonstrate the tremendous potential of bb-NIRS as a non-invasive in vivo means to study photobiomodulation mechanisms and perform treatment evaluations of TILS.

  5. Control over high peak-power laser light and laser-driven X-rays

    NASA Astrophysics Data System (ADS)

    Zhao, Baozhen; Banerjee, Sudeep; Yan, Wenchao; Zhang, Ping; Zhang, Jun; Golovin, Grigory; Liu, Cheng; Fruhling, Colton; Haden, Daniel; Chen, Shouyuan; Umstadter, Donald

    2018-04-01

    An optical system was demonstrated that enables continuous control over the peak power level of ultrashort duration laser light. The optical characteristics of amplified and compressed femtosecond-duration light from a chirped-pulse amplification laser are shown to remain invariant and maintain high-fidelity using this system. When the peak power was varied by an order-of-magnitude, up to its maximum attainable value, the phase, spectral bandwidth, polarization state, and focusability of the light remained constant. This capability led to precise control of the focused laser intensity and enabled a correspondingly high level of control over the power of an all-laser-driven Thomson X-ray light source.

  6. Laser-induced down-conversion and infrared phosphorescence emissivity of novel ligand-free perovskite nanomaterials

    NASA Astrophysics Data System (ADS)

    Ahmed, M. A.; Khafagy, Rasha M.; El-sayed, O.

    2014-03-01

    For the first time, standalone and ligand-free series of novel rare-earth-based perovskite nanomaterials are used as near infrared (NIR) and mid infrared (MIR) emitters. Nano-sized La0.7Sr0.3M0.1Fe0.9O3; where M = 0, Mn2+, Co2+ or Ni2+ were synthesized using the flash auto-combustion method and characterized using FTIR, FT-Raman, SEM and EDX. Photoluminescence spectra were spontaneously recorded during pumping the samples with 0.5 mW of green laser emitting continuously at 532 nm. La0.7Sr0.3FeO3 (where M = 0) did not result in any infrared emissivity, while intense near and mid infrared down-converted phosphorescence was released from the M-doped samples. The released phosphorescence greatly shifted among the infrared spectral region with changing the doping cation. Ni2+-doped perovskite emitted at the short-wavelength near-infrared region, while Mn2+ and Co2+-doped perovskites emitted at the mid-wavelength infrared region. The detected laser-induced spontaneous parametric down-conversion phosphorescence (SPDC) occurred through a two-photon process by emitting two NIR or MIR photons among a cooperative energy transfer between the La3+ cations and the M2+ cations. Combining SrFeO3 ceramic with both a rare earth cation (RE3+) and a transition metal cation (Mn2+, Co2+ or Ni2+), rather than introducing merely RE3+ cations, greatly improved and controlled the infrared emissivity properties of synthesized perovskites through destroying their crystal symmetry and giving rise to asymmetrical lattice vibration and the nonlinear optical character. The existence of SPDC in the M2+-doped samples verifies their nonlinear character after the absence of this character in La0.7Sr0.3FeO3. Obtained results verify that, for the first time, perovskite nanomaterials are considered as nonlinear optical crystals with intense infrared emissivity at low pumping power of visible wavelengths, which nominates them for photonic applications and requires further studies regarding their lasing

  7. Application and possible mechanisms of combining LLLT (low level laser therapy), infrared hyperthermia and ionizing radiation in the treatment of cancer

    NASA Astrophysics Data System (ADS)

    Abraham, Edward H.; Woo, Van H.; Harlin-Jones, Cheryl; Heselich, Anja; Frohns, Florian

    2014-02-01

    Benefit of concomitant infrared hyperthermia and low level laser therapy and ionizing radiation is evaluated in this study. The purpose/objectives: presentation with locally advanced bulky superficial tumors is clinically challenging. To enhance the efficacy of chemotherapy and IMRT (intensity-modulated radiation therapy) and/or electron beam therapy we have developed an inexpensive and clinically effective infrared hyperthermia approach that combines black-body infrared radiation with halogen spectrum radiation and discrete wave length infrared clinical lasers LLLT. The goal is to produce a composite spectrum extending from the far infrared to near infrared and portions of the visible spectrum with discrete penetrating wavelengths generated by the clinical infrared lasers with frequencies of 810 nm and/or 830 nm. The composite spectrum from these sources is applied before and after radiation therapy. We monitor the surface and in some cases deeper temperatures with thermal probes, but use an array of surface probes as the limiting safe thermal constraint in patient treatment while at the same time maximizing infrared entry to deeper tissue layers. Fever-grade infrared hyperthermia is produced in the first centimeters while non-thermal infrared effects act at deeper tissue layers. The combination of these effects with ionizing radiation leads to improved tumor control in many cancers.

  8. Infrared upconversion for astronomical applications. [laser applications to astronomical spectroscopy of infrared spectra

    NASA Technical Reports Server (NTRS)

    Abbas, M. M.; Kostiuk, T.; Ogilvie, K. W.

    1975-01-01

    The performance of an upconversion system is examined for observation of astronomical sources in the low to middle infrared spectral range. Theoretical values for the performance parameters of an upconversion system for astronomical observations are evaluated in view of the conversion efficiencies, spectral resolution, field of view, minimum detectable source brightness and source flux. Experimental results of blackbody measurements and molecular absorption spectrum measurements using a lithium niobate upconverter with an argon-ion laser as the pump are presented. Estimates of the expected optimum sensitivity of an upconversion device which may be built with the presently available components are given.

  9. Laser eye protection bleaching with femtosecond exposure

    NASA Astrophysics Data System (ADS)

    Stolarski, Jacob; Hayes, Kristy L.; Thomas, Robert J.; Noojin, Gary D.; Stolarski, David J.; Rockwell, Benjamin A.

    2003-06-01

    The measured optical density of various laser eye protection samples is presented as a function of irradiance using femtosecond laser pulses. We show that the protective quality of some eyewear degrades as irradiance increases. In previous studies this problem has been demonstrated for samples irradiated by nanosecond pulses, but the current study shows that some modern laser eye protection seems to be robust except for the irradiance level possible with ultrashort laser pulse exposure. We discuss the most likely saturation mechanisms in this pulse duration regime and its relevance to laser safety.

  10. Integrated ultraviolet and tunable mid-infrared laser source for analyses of proteins

    NASA Astrophysics Data System (ADS)

    Hazama, Hisanao; Takatani, Yoshiaki; Awazu, Kunio

    2007-02-01

    Mass spectrometry using matrix-assisted laser desorption/ionization (MALDI) technique is one of the most widely used method to analyze proteins in biological research fields. However, it is difficult to analyze insoluble proteins which have important roles in researches on disease mechanisms or in developments of drugs by using ultraviolet (UV) lasers which have commonly been used for MALDI. Recently, a significant improvement in MALDI process of insoluble proteins using a combination of a UV nitrogen laser and a tunable mid-infrared (MIR) free electron laser (FEL) was reported. Since the FEL is a very large and expensive equipment, we have developed a tabletop laser source which can generate both UV and tunable MIR lasers. A tunable MIR laser (5.5-10 μm) was obtained by difference frequency generation (DFG) between a Nd:YAG and a tunable Cr:forsterite lasers using two AgGaS II crystals. The MIR laser can generate pulses with an energy of up to 1.4 mJ at a repetition rate of 10 Hz. A UV laser was obtained by third harmonic generation of a Nd:YAG laser splitted from that used for DFG. A time interval between the UV and the MIR laser pulses can be adjusted with a variable optical delay.

  11. Theoretical investigation of injection-locked high modulation bandwidth quantum cascade lasers.

    PubMed

    Meng, Bo; Wang, Qi Jie

    2012-01-16

    In this study, we report for the first time to our knowledge theoretical investigation of modulation responses of injection-locked mid-infrared quantum cascade lasers (QCLs) at wavelengths of 4.6 μm and 9 μm, respectively. It is shown through a three-level rate equations model that the direct intensity modulation of QCLs gives the maximum modulation bandwidths of ~7 GHz at 4.6 μm and ~20 GHz at 9 μm. By applying the injection locking scheme, we find that the modulation bandwidths of up to ~30 GHz and ~70 GHz can be achieved for QCLs at 4.6 μm and 9 μm, respectively, with an injection ratio of 5 dB. The result also shows that an ultrawide modulation bandwidth of more than 200 GHz is possible with a 10 dB injection ratio for QCLs at 9 μm. An important characteristic of injection-locked QCLs is the nonexistence of unstable locking region in the locking map, in contrast to their diode laser counterparts. We attribute this to the ultra-short upper laser state lifetimes of QCLs.

  12. Photothermal effect of infrared lasers on ex vivo lamb brain tissues

    NASA Astrophysics Data System (ADS)

    Özgürün, Baturay; Gülsoy, Murat

    2018-02-01

    Here, the most suitable infrared laser for a neurosurgery operation is suggested, among 1940-nm thulium fiber, 1470-nm diode, 1070-nm ytterbium fiber and 980-nm diode lasers. Cortical and subcortical ex-vivo lamb brain tissues are exposed to the laser light with the combinations of some laser parameters such as output power, energy density, operation mode (continuous and pulsed-modulated) and operation time. In this way, the greatest ablation efficiency associated with the best neurosurgical laser type can be defined. The research can be divided into two parts; pre-dosimetry and dosimetry studies. The former is used to determine safe operation zones for the dosimetry study by defining coagulation and carbonization onset times for each of the brain tissues. The latter is the main part of this research, and both tissues are exposed to laser irradiation with various energy density levels associated with the output power and operation time. In addition, photo-thermal effects are compared for two laser operation modes, and then coagulation and ablation diameters to calculate the ablation efficiency are measured under a light microscope. Consequently, results are compared graphically and statistically, and it is found that thulium and 1470-nm diode lasers can be utilized as subcortical and cortical tissue ablator devices, respectively.

  13. Vibrational mid-infrared photothermal spectroscopy using a fiber laser probe: asymptotic limit in signal-to-baseline contrast.

    PubMed

    Totachawattana, Atcha; Liu, Hui; Mertiri, Alket; Hong, Mi K; Erramilli, Shyamsunder; Sander, Michelle Y

    2016-01-01

    We report on a mid-infrared photothermal spectroscopy system with a near-infrared fiber probe laser and a tunable quantum cascade pump laser. Photothermal spectra of a 6 μm-thick 4-octyl-4'-cyanobiphenyl liquid crystal sample are measured with a signal-to-baseline contrast above 103. As both the peak photothermal signal and the corresponding baseline increase linearly with probe power, the signal-to-baseline contrast converges to an asymptotic limit for a given pump power. This limit is independent of the probe power and characterizes the best contrast achievable for the system. This enables sensitive quantitative spectral characterization of linear infrared absorption features directly from photothermal spectroscopy measurements.

  14. Highly efficient broadband terahertz generation from ultrashort laser filamentation in liquids.

    PubMed

    Dey, Indranuj; Jana, Kamalesh; Fedorov, Vladimir Yu; Koulouklidis, Anastasios D; Mondal, Angana; Shaikh, Moniruzzaman; Sarkar, Deep; Lad, Amit D; Tzortzakis, Stelios; Couairon, Arnaud; Kumar, G Ravindra

    2017-10-30

    Generation and application of energetic, broadband terahertz pulses (bandwidth ~0.1-50 THz) is an active and contemporary area of research. The main thrust is toward the development of efficient sources with minimum complexities-a true table-top setup. In this work, we demonstrate the generation of terahertz radiation via ultrashort pulse induced filamentation in liquids-a counterintuitive observation due to their large absorption coefficient in the terahertz regime. The generated terahertz energy is more than an order of magnitude higher than that obtained from the two-color filamentation of air (the most standard table-top technique). Such high terahertz energies would generate electric fields of the order of MV cm -1 , which opens the doors for various nonlinear terahertz spectroscopic applications. The counterintuitive phenomenon has been explained via the solution of nonlinear pulse propagation equation in the liquid medium.

  15. Novel T-shaped GaSb/InAsN quantum wire for mid-infrared laser applications

    NASA Astrophysics Data System (ADS)

    Ridene, Said

    2017-10-01

    In this work, we investigate GaSb /InAs1-xNx T-shaped quantum wire active region in mid-infrared laser. Multi-band k.p model and variational formalism are applied to find the confinement energies, the band structures, and optical gain. We then present a method of numerical calculation that is suited to any T-shaped quantum wire. By tuning the quantum wire thickness, the TE- and TM-polarized optical gain up to 21 ×103 cm-1 can be obtained for λ = 3.11 μm at room temperature (RT), which is very promising to serve as an alternative active region for high-efficiency mid-infrared laser applications.

  16. Remote electrical arc suppression by laser filamentation.

    PubMed

    Schubert, Elise; Mongin, Denis; Kasparian, Jérôme; Wolf, Jean-Pierre

    2015-11-02

    We investigate the interaction of narrow plasma channels formed in the filamentation of ultrashort laser pulses, with a DC high voltage. The laser filaments prevent electrical arcs by triggering corona that neutralize the high-voltage electrodes. This phenomenon, that relies on the electric field modulation and free electron release around the filament, opens new prospects to lightning and over-voltage mitigation.

  17. Pulse energy dependence of subcellular dissection by femtosecond laser pulses

    NASA Technical Reports Server (NTRS)

    Heisterkamp, A.; Maxwell, I. Z.; Mazur, E.; Underwood, J. M.; Nickerson, J. A.; Kumar, S.; Ingber, D. E.

    2005-01-01

    Precise dissection of cells with ultrashort laser pulses requires a clear understanding of how the onset and extent of ablation (i.e., the removal of material) depends on pulse energy. We carried out a systematic study of the energy dependence of the plasma-mediated ablation of fluorescently-labeled subcellular structures in the cytoskeleton and nuclei of fixed endothelial cells using femtosecond, near-infrared laser pulses focused through a high-numerical aperture objective lens (1.4 NA). We find that the energy threshold for photobleaching lies between 0.9 and 1.7 nJ. By comparing the changes in fluorescence with the actual material loss determined by electron microscopy, we find that the threshold for true material ablation is about 20% higher than the photobleaching threshold. This information makes it possible to use the fluorescence to determine the onset of true material ablation without resorting to electron microscopy. We confirm the precision of this technique by severing a single microtubule without disrupting the neighboring microtubules, less than 1 micrometer away. c2005 Optical Society of America.

  18. Infrared laser effects at fluences used for treatment of dentin hypersensitivity on DNA repair in Escherichia coli and plasmids

    NASA Astrophysics Data System (ADS)

    Rocha Teixeira, Gleica; da Silva Marciano, Roberta; da Silva Sergio, Luiz Philippe; Castanheira Polignano, Giovanni Augusto; Roberto Guimarães, Oscar; Geller, Mauro; de Paoli, Flavia; de Souza da Fonseca, Adenilson

    2014-12-01

    Low-intensity infrared lasers are proposed in clinical protocols based on biostimulative effects, yet dosimetry is inaccurate and their effects on DNA at therapeutic doses are controversial. The aim of this work was to evaluate the effects of low-intensity infrared laser on survival and induction of filamentation of Escherichia coli cells, and induction of DNA lesions in bacterial plasmids. E. coli cultures were exposed to laser (808 nm, 100 mW, 40 and 60 J/cm2) to study bacterial survival and filamentation. Also, bacterial plasmids were exposed to laser to study DNA lesions by electrophoretic profile and action of DNA repair enzymes. Data indicate low-intensity infrared laser has no effect on survival of E. coli wild type and exonuclease III, but decreases the survival of formamidopyrimidine DNA glycosylase/MutM protein and endonuclease III deficient cells in stationary growth phase, induces bacterial filamentation, does not alter the electrophoretic profile of plasmids in agarose gels and does not alter the electrophoretic profile of plasmids incubated with endonuclease III, formamidopyrimidine DNA glycosylase/MutM protein and exonuclease III. Our findings show that low-intensity laser exposure causes DNA lesions at sub-lethal level and induces cellular mechanisms involved in repair of oxidative lesions in DNA. Studies about laser dosimetry and safety strategies are necessary for professionals and patients exposed to low-intensity lasers at therapeutic doses.

  19. Nucleotide excision repair pathway assessment in DNA exposed to low-intensity red and infrared lasers.

    PubMed

    Fonseca, A S; Campos, V M A; Magalhães, L A G; Paoli, F

    2015-10-01

    Low-intensity lasers are used for prevention and management of oral mucositis induced by anticancer therapy, but the effectiveness of treatment depends on the genetic characteristics of affected cells. This study evaluated the survival and induction of filamentation of Escherichia coli cells deficient in the nucleotide excision repair pathway, and the action of T4endonuclease V on plasmid DNA exposed to low-intensity red and near-infrared laser light. Cultures of wild-type (strain AB1157) E. coli and strain AB1886 (deficient in uvrA protein) were exposed to red (660 nm) and infrared (808 nm) lasers at various fluences, powers and emission modes to study bacterial survival and filamentation. Also, plasmid DNA was exposed to laser light to study DNA lesions produced in vitro by T4endonuclease V. Low-intensity lasers:i) had no effect on survival of wild-type E. coli but decreased the survival of uvrA protein-deficient cells,ii) induced bacterial filamentation, iii) did not alter the electrophoretic profile of plasmids in agarose gels, andiv) did not alter the electrophoretic profile of plasmids incubated with T4 endonuclease V. These results increase our understanding of the effects of laser light on cells with various genetic characteristics, such as xeroderma pigmentosum cells deficient in nucleotide excision pathway activity in patients with mucositis treated by low-intensity lasers.

  20. Nucleotide excision repair pathway assessment in DNA exposed to low-intensity red and infrared lasers

    PubMed Central

    Fonseca, A.S.; Campos, V.M.A.; Magalhães, L.A.G.; Paoli, F.

    2015-01-01

    Low-intensity lasers are used for prevention and management of oral mucositis induced by anticancer therapy, but the effectiveness of treatment depends on the genetic characteristics of affected cells. This study evaluated the survival and induction of filamentation of Escherichia coli cells deficient in the nucleotide excision repair pathway, and the action of T4endonuclease V on plasmid DNA exposed to low-intensity red and near-infrared laser light. Cultures of wild-type (strain AB1157) E. coli and strain AB1886 (deficient in uvrA protein) were exposed to red (660 nm) and infrared (808 nm) lasers at various fluences, powers and emission modes to study bacterial survival and filamentation. Also, plasmid DNA was exposed to laser light to study DNA lesions produced in vitro by T4endonuclease V. Low-intensity lasers:i) had no effect on survival of wild-type E. coli but decreased the survival of uvrA protein-deficient cells,ii) induced bacterial filamentation, iii) did not alter the electrophoretic profile of plasmids in agarose gels, andiv) did not alter the electrophoretic profile of plasmids incubated with T4 endonuclease V. These results increase our understanding of the effects of laser light on cells with various genetic characteristics, such as xeroderma pigmentosum cells deficient in nucleotide excision pathway activity in patients with mucositis treated by low-intensity lasers. PMID:26445337

  1. Infrared absorption nano-spectroscopy using sample photoexpansion induced by tunable quantum cascade lasers.

    PubMed

    Lu, Feng; Belkin, Mikhail A

    2011-10-10

    We report a simple technique that allows obtaining mid-infrared absorption spectra with nanoscale spatial resolution under low-power illumination from tunable quantum cascade lasers. Light absorption is detected by measuring associated sample thermal expansion with an atomic force microscope. To detect minute thermal expansion we tune the repetition frequency of laser pulses in resonance with the mechanical frequency of the atomic force microscope cantilever. Spatial resolution of better than 50 nm is experimentally demonstrated.

  2. Modelling ultrafast laser ablation

    NASA Astrophysics Data System (ADS)

    Rethfeld, Baerbel; Ivanov, Dmitriy S.; E Garcia, Martin; Anisimov, Sergei I.

    2017-05-01

    This review is devoted to the study of ultrafast laser ablation of solids and liquids. The ablation of condensed matter under exposure to subpicosecond laser pulses has a number of peculiar properties which distinguish this process from ablation induced by nanosecond and longer laser pulses. The process of ultrafast ablation includes light absorption by electrons in the skin layer, energy transfer from the skin layer to target interior by nonlinear electronic heat conduction, relaxation of the electron and ion temperatures, ultrafast melting, hydrodynamic expansion of heated matter accompanied by the formation of metastable states and subsequent formation of breaks in condensed matter. In case of ultrashort laser excitation, these processes are temporally separated and can thus be studied separately. As for energy absorption, we consider peculiarities of the case of metal irradiation in contrast to dielectrics and semiconductors. We discuss the energy dissipation processes of electronic thermal wave and lattice heating. Different types of phase transitions after ultrashort laser pulse irradiation as melting, vaporization or transitions to warm dense matter are discussed. Also nonthermal phase transitions, directly caused by the electronic excitation before considerable lattice heating, are considered. The final material removal occurs from the physical point of view as expansion of heated matter; here we discuss approaches of hydrodynamics, as well as molecular dynamic simulations directly following the atomic movements. Hybrid approaches tracing the dynamics of excited electrons, energy dissipation and structural dynamics in a combined simulation are reviewed as well.

  3. Genomic Physics. Multiple Laser Beam Treatment of Alzheimer's Disease

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2014-03-01

    The synapses affected by Alzheimer's disease can be rejuvenated by the multiple ultrashort wavelength laser beams.[2] The guiding lasers scan the whole area to detect the amyloid plaques based on the laser scattering technique. The scanning lasers pinpoint the areas with plaques and eliminate them. Laser interaction is highly efficient, because of the focusing capabilities and possibility for the identification of the damaging proteins by matching the protein oscillation eigen-frequency with laser frequency.[3] Supported by Nikola Tesla Labs, La Jolla, California, USA.

  4. Stanford MFEL and Near Infrared Science Center

    DTIC Science & Technology

    2011-01-28

    guiding procedures for restoration of hearing— cochlear implants. Multifaceted approaches have been taken to understand the molecular and cellular...accompanying phenomena of cavitation, liquid flow and heat transfer in various biological tissues. In the field of laser surgery with ultrashort pulses...using yeast cell surface display, the Cochran group has generated EGF mutant libraries and have screened them by flow cytometry using fluorescently

  5. Infrared and visible laser spectroscopy for highly-charged Ni-like ions

    NASA Astrophysics Data System (ADS)

    Ralchenko, Yuri

    2017-10-01

    Application of visible or infrared (IR) lasers for spectroscopy of highly-charged ions (HCI) has not been particularly extensive so far due to a mismatch in typical energies. We show here that the energy difference between the two lowest levels within the first excited configuration 3d9 4 s in Ni-like ions of heavy elements from ZN = 60 to ZN = 92 is within the range of visible or near-IR lasers. The wavelengths of these transitions are calculated within the relativistic model potential formalism and compared with other theoretical and limited experimental data. Detailed collisional-radiative simulations of non-Maxwellian and thermal plasmas are performed showing that photopumping between these levels using relatively moderate lasers is sufficient to provide a two-order of magnitude increase of the pumped level population. This accordingly results in a similar rise of the X-ray line intensity thereby allowing control of X-ray emission with visible/IR lasers.

  6. Molecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stress

    PubMed Central

    Khan, Imran; Tang, Elieza; Arany, Praveen

    2015-01-01

    High power lasers are used extensively in medicine while lower power applications are popular for optical imaging, optogenetics, skin rejuvenation and a therapeutic modality termed photobiomodulation (PBM). This study addresses the therapeutic dose limits, biological safety and molecular pathway of near-infrared (NIR) laser phototoxicity. Increased erythema and tissue damage were noted in mice skin and cytotoxicity in cell cultures at phototoxic laser doses involving generation of reactive oxygen species (ROS) coupled with a rise in surface temperature (>45 °C). NIR laser phototoxicity results from Activating Transcription Factor-4 (ATF-4) mediated endoplasmic reticulum stress and autophagy. Neutralizations of heat or ROS and overexpressing ATF-4 were noted to rescue NIR laser phototoxicity. Further, NIR laser mediated phototoxicity was noted to be non-genotoxic and non-mutagenic. This study outlines the mechanism of NIR laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications. PMID:26030745

  7. Molecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stress.

    PubMed

    Khan, Imran; Tang, Elieza; Arany, Praveen

    2015-06-01

    High power lasers are used extensively in medicine while lower power applications are popular for optical imaging, optogenetics, skin rejuvenation and a therapeutic modality termed photobiomodulation (PBM). This study addresses the therapeutic dose limits, biological safety and molecular pathway of near-infrared (NIR) laser phototoxicity. Increased erythema and tissue damage were noted in mice skin and cytotoxicity in cell cultures at phototoxic laser doses involving generation of reactive oxygen species (ROS) coupled with a rise in surface temperature (>45 °C). NIR laser phototoxicity results from Activating Transcription Factor-4 (ATF-4) mediated endoplasmic reticulum stress and autophagy. Neutralizations of heat or ROS and overexpressing ATF-4 were noted to rescue NIR laser phototoxicity. Further, NIR laser mediated phototoxicity was noted to be non-genotoxic and non-mutagenic. This study outlines the mechanism of NIR laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications.

  8. Harmonizing HeLa cell cytoskeleton behavior by multi-Ti oxide phased nanostructure synthesized through ultrashort pulsed laser

    PubMed Central

    Chinnakkannu Vijayakumar, Chandramouli; Venkatakrishnan, Krishnan; Tan, Bo

    2015-01-01

    Knowledge about cancer cell behavior on heterogeneous nanostructures is relevant for developing a distinct biomaterial that can actuate cancer cells. In this manuscript, we have demonstrated a harmonized approach of forming multi Ti-oxide phases in a nanostructure (MTOP nanostructure) for its unique cancer cell controlling behavior.Conventionally, single phases of TiO2 are used for targeted therapy and as drug carrier systems.In this research, we have shown a biomaterial that can control HeLa cells diligently using a combination of TiO, Ti3O and TiO2 phases when compared to fibroblast (NIH3T3) cells.MTOP-nanostructures are generated by varying the ionization energy in the vapor plume of the ultrashort pulse laser; this interaction with the material allows accurate tuning and composition of phases within the nanostructure. In addition, the lattice spacing of MTOP-nanostructures was analyzed as shown by HR-TEM investigations. An FESEM investigation of MTOP-nanostructures revealed a greater reduction of HeLa cells relative to fibroblast cells. Altered cell adhesion was followed by modulation of HeLa cell architecture with a significant reduction of actin stress fibers.The intricate combination of MTOP-nanostructures renders a biomaterial that can precisely alter HeLa cell but not fibroblast cell behavior, filling a void in the research for a biomaterial to modulate cancer cell behavior. PMID:26469886

  9. Harmonizing HeLa cell cytoskeleton behavior by multi-Ti oxide phased nanostructure synthesized through ultrashort pulsed laser

    NASA Astrophysics Data System (ADS)

    Chinnakkannu Vijayakumar, Chandramouli; Venkatakrishnan, Krishnan; Tan, Bo

    2015-10-01

    Knowledge about cancer cell behavior on heterogeneous nanostructures is relevant for developing a distinct biomaterial that can actuate cancer cells. In this manuscript, we have demonstrated a harmonized approach of forming multi Ti-oxide phases in a nanostructure (MTOP nanostructure) for its unique cancer cell controlling behavior.Conventionally, single phases of TiO2 are used for targeted therapy and as drug carrier systems.In this research, we have shown a biomaterial that can control HeLa cells diligently using a combination of TiO, Ti3O and TiO2 phases when compared to fibroblast (NIH3T3) cells.MTOP-nanostructures are generated by varying the ionization energy in the vapor plume of the ultrashort pulse laser; this interaction with the material allows accurate tuning and composition of phases within the nanostructure. In addition, the lattice spacing of MTOP-nanostructures was analyzed as shown by HR-TEM investigations. An FESEM investigation of MTOP-nanostructures revealed a greater reduction of HeLa cells relative to fibroblast cells. Altered cell adhesion was followed by modulation of HeLa cell architecture with a significant reduction of actin stress fibers.The intricate combination of MTOP-nanostructures renders a biomaterial that can precisely alter HeLa cell but not fibroblast cell behavior, filling a void in the research for a biomaterial to modulate cancer cell behavior.

  10. Patient identification using a near-infrared laser scanner

    NASA Astrophysics Data System (ADS)

    Manit, Jirapong; Bremer, Christina; Schweikard, Achim; Ernst, Floris

    2017-03-01

    We propose a new biometric approach where the tissue thickness of a person's forehead is used as a biometric feature. Given that the spatial registration of two 3D laser scans of the same human face usually produces a low error value, the principle of point cloud registration and its error metric can be applied to human classification techniques. However, by only considering the spatial error, it is not possible to reliably verify a person's identity. We propose to use a novel near-infrared laser-based head tracking system to determine an additional feature, the tissue thickness, and include this in the error metric. Using MRI as a ground truth, data from the foreheads of 30 subjects was collected from which a 4D reference point cloud was created for each subject. The measurements from the near-infrared system were registered with all reference point clouds using the ICP algorithm. Afterwards, the spatial and tissue thickness errors were extracted, forming a 2D feature space. For all subjects, the lowest feature distance resulted from the registration of a measurement and the reference point cloud of the same person. The combined registration error features yielded two clusters in the feature space, one from the same subject and another from the other subjects. When only the tissue thickness error was considered, these clusters were less distinct but still present. These findings could help to raise safety standards for head and neck cancer patients and lays the foundation for a future human identification technique.

  11. Photoacoustic-based detector for infrared laser spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scholz, L.; Palzer, S., E-mail: stefan.palzer@imtek.uni-freiburg.de

    In this contribution, we present an alternative detector technology for use in direct absorption spectroscopy setups. Instead of a semiconductor based detector, we use the photoacoustic effect to gauge the light intensity. To this end, the target gas species is hermetically sealed under excess pressure inside a miniature cell along with a MEMS microphone. Optical access to the cell is provided by a quartz window. The approach is particularly suitable for tunable diode laser spectroscopy in the mid-infrared range, where numerous molecules exhibit large absorption cross sections. Moreover, a frequency standard is integrated into the method since the number densitymore » and pressure inside the cell are constant. We demonstrate that the information extracted by our method is at least equivalent to that achieved using a semiconductor-based photon detector. As exemplary and highly relevant target gas, we have performed direct spectroscopy of methane at the R3-line of the 2v{sub 3} band at 6046.95 cm{sup −1} using both detector technologies in parallel. The results may be transferred to other infrared-active transitions without loss of generality.« less

  12. TruMicro Series 2000 sub-400 fs class industrial fiber lasers: adjustment of laser parameters to process requirements

    NASA Astrophysics Data System (ADS)

    Kanal, Florian; Kahmann, Max; Tan, Chuong; Diekamp, Holger; Jansen, Florian; Scelle, Raphael; Budnicki, Aleksander; Sutter, Dirk

    2017-02-01

    The matchless properties of ultrashort laser pulses, such as the enabling of cold processing and non-linear absorption, pave the way to numerous novel applications. Ultrafast lasers arrived in the last decade at a level of reliability suitable for the industrial environment.1 Within the next years many industrial manufacturing processes in several markets will be replaced by laser-based processes due to their well-known benefits: These are non-contact wear-free processing, higher process accuracy or an increase of processing speed and often improved economic efficiency compared to conventional processes. Furthermore, new processes will arise with novel sources, addressing previously unsolved challenges. One technical requirement for these exciting new applications will be to optimize the large number of available parameters to the requirements of the application. In this work we present an ultrafast laser system distinguished by its capability to combine high flexibility and real time process-inherent adjustments of the parameters with industry-ready reliability. This industry-ready reliability is ensured by a long experience in designing and building ultrashort-pulse lasers in combination with rigorous optimization of the mechanical construction, optical components and the entire laser head for continuous performance. By introducing a new generation of mechanical design in the last few years, TRUMPF enabled its ultrashort-laser platforms to fulfill the very demanding requirements for passively coupling high-energy single-mode radiation into a hollow-core transport fiber. The laser architecture presented here is based on the all fiber MOPA (master oscillator power amplifier) CPA (chirped pulse amplification) technology. The pulses are generated in a high repetition rate mode-locked fiber oscillator also enabling flexible pulse bursts (groups of multiple pulses) with 20 ns intra-burst pulse separation. An external acousto-optic modulator (XAOM) enables linearization

  13. High power tunable mid-infrared optical parametric oscillator enabled by random fiber laser.

    PubMed

    Wu, Hanshuo; Wang, Peng; Song, Jiaxin; Ye, Jun; Xu, Jiangming; Li, Xiao; Zhou, Pu

    2018-03-05

    Random fiber laser, as a kind of novel fiber laser that utilizes random distributed feedback as well as Raman gain, has become a research focus owing to its advantages of wavelength flexibility, modeless property and output stability. Herein, a tunable optical parametric oscillator (OPO) enabled by a random fiber laser is reported for the first time. By exploiting a tunable random fiber laser to pump the OPO, the central wavelength of idler light can be continuously tuned from 3977.34 to 4059.65 nm with stable temporal average output power. The maximal output power achieved is 2.07 W. So far as we know, this is the first demonstration of a continuous-wave tunable OPO pumped by a tunable random fiber laser, which could not only provide a new approach for achieving tunable mid-infrared (MIR) emission, but also extend the application scenarios of random fiber lasers.

  14. [INVITED] Laser welding of glasses at high repetition rates - Fundamentals and prospects

    NASA Astrophysics Data System (ADS)

    Richter, Sören; Zimmermann, Felix; Tünnermann, Andreas; Nolte, Stefan

    2016-09-01

    We report on the welding of various glasses with ultrashort laser pulses. Femtosecond laser pulses at repetition rates in the MHz range are focused at the interface between two substrates, resulting in multiphoton absorption and heat accumulation from successive pulses. This leads to local melting and subsequent resolidification which can be used to weld the glasses. The fundamental interaction process was studied using an in-situ micro Raman setup to measure the laser induced temperature distribution and its temporal decay. The induced network changes were analyzed by Raman spectrocopy identifying an increase of three and four membered silicon rings within the laser irradiated area. In order to determine the stability of the laser welded samples a three point bending test was used. Thereby, we identified that the maximal achievable breaking strength is limited by laser induced stress surrounding the modified material. To minimize the amount of stress bursts of laser pulses or an post processing annealing step can be applied. Besides fused silica, we welded borosilicate glasses and glasses with a low thermal expansion coefficient. Even the welding of different glass combinations is possible demonstrating the versatility of ultrashort pulse induced laser welding.

  15. Photopumped infrared vertical-cavity surface-emitting laser

    NASA Astrophysics Data System (ADS)

    Hadji, E.; Bleuse, J.; Magnea, N.; Pautrat, J. L.

    1996-04-01

    The feasibility of a photopumped infrared vertical-cavity surface-emitting laser (VCSEL) based on CdHgTe alloys is demonstrated. The structure of the VCSEL consists of a 16.5-period Cd0.4Hg0.6Te/Cd0.75Hg0.25Te bottom Bragg reflector and a 3λ/4 thick Cd0.75Hg0.25Te cavity, containing a 100-nm-thick well, grown by molecular beam epitaxy. The top mirror is a 7-period YF3/ZnS dielectric stack. The cavity quality factor is Q=350. This heterostructure VCSEL operates at 3.06 μm with a measured power density threshold of 45 kW/cm2 at 10 K.

  16. Near infra-red astronomy with adaptive optics and laser guide stars at the Keck Observatory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Max, C.E.; Gavel, D.T.; Olivier, S.S.

    1995-08-03

    A laser guide star adaptive optics system is being built for the W. M. Keck Observatory`s 10-meter Keck II telescope. Two new near infra-red instruments will be used with this system: a high-resolution camera (NIRC 2) and an echelle spectrometer (NIRSPEC). The authors describe the expected capabilities of these instruments for high-resolution astronomy, using adaptive optics with either a natural star or a sodium-layer laser guide star as a reference. They compare the expected performance of these planned Keck adaptive optics instruments with that predicted for the NICMOS near infra-red camera, which is scheduled to be installed on the Hubblemore » Space Telescope in 1997.« less

  17. High-speed mid-infrared hyperspectral imaging using quantum cascade lasers

    NASA Astrophysics Data System (ADS)

    Kelley, David B.; Goyal, Anish K.; Zhu, Ninghui; Wood, Derek A.; Myers, Travis R.; Kotidis, Petros; Murphy, Cara; Georgan, Chelsea; Raz, Gil; Maulini, Richard; Müller, Antoine

    2017-05-01

    We report on a standoff chemical detection system using widely tunable external-cavity quantum cascade lasers (ECQCLs) to illuminate target surfaces in the mid infrared (λ = 7.4 - 10.5 μm). Hyperspectral images (hypercubes) are acquired by synchronously operating the EC-QCLs with a LN2-cooled HgCdTe camera. The use of rapidly tunable lasers and a high-frame-rate camera enables the capture of hypercubes with 128 x 128 pixels and >100 wavelengths in <0.1 s. Furthermore, raster scanning of the laser illumination allowed imaging of a 100-cm2 area at 5-m standoff. Raw hypercubes are post-processed to generate a hypercube that represents the surface reflectance relative to that of a diffuse reflectance standard. Results will be shown for liquids (e.g., silicone oil) and solid particles (e.g., caffeine, acetaminophen) on a variety of surfaces (e.g., aluminum, plastic, glass). Signature spectra are obtained for particulate loadings of RDX on glass of <1 μg/cm2.

  18. Research of infrared laser based pavement imaging and crack detection

    NASA Astrophysics Data System (ADS)

    Hong, Hanyu; Wang, Shu; Zhang, Xiuhua; Jing, Genqiang

    2013-08-01

    Road crack detection is seriously affected by many factors in actual applications, such as some shadows, road signs, oil stains, high frequency noise and so on. Due to these factors, the current crack detection methods can not distinguish the cracks in complex scenes. In order to solve this problem, a novel method based on infrared laser pavement imaging is proposed. Firstly, single sensor laser pavement imaging system is adopted to obtain pavement images, high power laser line projector is well used to resist various shadows. Secondly, the crack extraction algorithm which has merged multiple features intelligently is proposed to extract crack information. In this step, the non-negative feature and contrast feature are used to extract the basic crack information, and circular projection based on linearity feature is applied to enhance the crack area and eliminate noise. A series of experiments have been performed to test the proposed method, which shows that the proposed automatic extraction method is effective and advanced.

  19. FIBER AND INTEGRATED OPTICS, LASER APPLICATIONS, AND OTHER PROBLEMS IN QUANTUM ELECTRONICS: Spectrometer based on injection lasers emitting near-infrared radiation

    NASA Astrophysics Data System (ADS)

    Avetisov, V. G.; Kosichkin, Yu V.; Malakhova, V. I.; Merkulov, A. V.; Nadezhdinskiĭ, A. I.; Paleĭ, S. L.; Khusnutdinov, A. N.; Yakubovich, S. D.

    1989-04-01

    A two-beam spectrometer utilizing injection lasers emitting in the near infrared was constructed. The spectrometer utilizes rapid scanning of the laser emission frequency followed by recording with an analog-digital converter. The spectrometer parameters are as follows: a spectral resolution of at least 2 × 10 -3 cm-1, a response time 50 ns, and a detectivity amounting to 0.0003% of the incident power carried by one pulse.

  20. Quantitative Species Measurements in Microgravity Combustion Flames using Near-Infrared Diode Lasers

    NASA Technical Reports Server (NTRS)

    Silver, Joel A.

    1999-01-01

    Understanding the physical phenomena controlling the ignition and spread of flames in microgravity has importance for space safety as well as for characterizing dynamical and chemical combustion processes which are normally masked by buoyancy and other gravity-related effects. Unfortunately, combustion is highly complicated by fluid mechanical and chemical kinetic processes, requiring the use of numerical modeling to compare with carefully designed experiments. More sophisticated diagnostic methods are needed to provide the kind of quantitative data necessary to characterize the properties of microgravity combustion as well as provide accurate feedback to improve the predictive capabilities of the models. Diode lasers are a natural choice for use under the severe conditions of low gravity experiments. Reliable, simple solid state operation at low power satisfies the operational restrictions imposed by drop towers, aircraft and space-based studies. Modulation wavelength absorption spectroscopy (WMS) provides a means to make highly sensitive and quantitative measurements of local gas concentration and, in certain cases, temperature. With near-infrared diode lasers, detection of virtually all major combustion species with extremely rapid response time is possible in an inexpensive package. Advancements in near-infrared diode laser fabrication technology and concurrent development of optical fibers for these lasers led to their use in drop towers. Since near-infrared absorption line strengths for overtone and combination vibrational transitions are weaker than the mid-infrared fundamental bands, WMS techniques are applied to increase detection sensitivity and allow measurement of the major combustion gases. In the first microgravity species measurement, Silver et al. mounted a fiber-coupled laser at the top of the NASA 2.2-sec drop tower and piped the light through a single-mode fiber to the drop rig. A fiber splitter divided the light into eight channels that directed

  1. Portable multiwavelength laser diode source for handheld photoacoustic devices

    NASA Astrophysics Data System (ADS)

    Canal, Celine; Laugustin, Arnaud; Kohl, Andreas; Rabot, Olivier

    2016-04-01

    The ageing population faces today an increase of chronic diseases such as rheumatism/arthritis, cancer and cardio vascular diseases for which appropriate treatments based on a diagnosis at an early-stage of the disease are required. Some imaging techniques are already available in order to get structural information. Within the non-invasive group, ultrasound images are common in these fields of medicine. However, there is a need for a point-of-care device for imaging smaller structures such as blood vessels that cannot be observed with purely ultrasound based devices. Photoacoustics proved to be an attractive candidate. This novel imaging technique combines pulsed laser light for excitation of tissues and an ultrasound transducer as a receptor. Introduction of this technique into the clinic requires to drastically shrink the size and cost of the expensive and bulky nanosecond lasers generally used for light emission. In that context, demonstration of ultra-short pulse emission with highly efficient laser diodes in the near-infrared range has been performed by Quantel, France. A multi-wavelength laser source as small as a hand emitted more than 1 mJ per wavelength with four different wavelengths available in pulses of about 90 ns. Such a laser source can be integrated into high sensitivity photoacoustic handheld systems due to their outstanding electrical-to-optical efficiency of about 25 %. Further work continues to decrease the pulse length as low as 40 ns while increasing the pulse energy to 2 mJ.

  2. Production of silver-silica core-shell nanocomposites using ultra-short pulsed laser ablation in nanoporous aqueous silica colloidal solutions

    NASA Astrophysics Data System (ADS)

    Santagata, A.; Guarnaccio, A.; Pietrangeli, D.; Szegedi, Á.; Valyon, J.; De Stefanis, A.; De Bonis, A.; Teghil, R.; Sansone, M.; Mollica, D.; Parisi, G. P.

    2015-05-01

    Ultra-short pulsed laser ablation of materials in liquid has been demonstrated to be a versatile technique for nanoparticles production. In a previous paper, it has been described, for the first time, how by laser ablation in a liquid system, silver nanoparticles can be loaded onto SBA-15 and MCM-41 supports which show promising catalytic properties for the oxidation of Volatile Organic Compounds (VOCs). The aim of the present research is to demonstrate the formation of stable silver-silica core-shell nanoparticles by direct laser ablation (Ti:Sa; 800 nm pulse duration: 120 fs repetition rate: 1 kHz, pulse energy: 3.6 mJ, fluence: 9 J cm  -  2) of a Ag target submerged in a static colloidal solution of MCM-41 or SBA-15 silica nanoporous materials. In previous studies, it was discovered that a side and negligible product of the laser ablation process of silver performed in water-silica systems, could be related to the formation of silver-silica core-shell nanoparticles. In order to emphasize this side process some modifications to the laser ablation experimental set-up were performed. Among these, the most important one, in order to favor the production of the core-shell systems, was to keep the liquid silica suspension firm. The laser generated nanomaterials were then analyzed using TEM morphologic characterization. By UV-vis absorption spectra the observed features have been related to components of the colloidal solution as well as to the number of the incident laser pulses. In this manner characterizations on both the process and the resulting suspension have been performed. Significant amount of small sized silver-silica core-shell nanoparticles have been detected in the studied systems. The size distribution, polydispersivity, UV-vis plasmonic bands and stability of the produced silver-silica core-shell nanocomposites have been related to the extent of damage induced in the nanoporous silica structure during the ablation procedure adopted

  3. Numerical analysis of laser ablation and damage in glass with multiple picosecond laser pulses.

    PubMed

    Sun, Mingying; Eppelt, Urs; Russ, Simone; Hartmann, Claudia; Siebert, Christof; Zhu, Jianqiang; Schulz, Wolfgang

    2013-04-08

    This study presents a novel numerical model for laser ablation and laser damage in glass including beam propagation and nonlinear absorption of multiple incident ultrashort laser pulses. The laser ablation and damage in the glass cutting process with a picosecond pulsed laser was studied. The numerical results were in good agreement with our experimental observations, thereby revealing the damage mechanism induced by laser ablation. Beam propagation effects such as interference, diffraction and refraction, play a major role in the evolution of the crater structure and the damage region. There are three different damage regions, a thin layer and two different kinds of spikes. Moreover, the electronic damage mechanism was verified and distinguished from heat modification using the experimental results with different pulse spatial overlaps.

  4. Infrared Smartt Interferometer As An Alignment Tool For Carbon Dioxide Laser Fusion Systems

    NASA Astrophysics Data System (ADS)

    Viswanathan, V. K.; Bolen, P. D.

    1980-11-01

    It is essential to minimize the pointing and focusing errors at the focal plane for many applications involving infrared laser systems. In the case of the LASL CO2 laser fusion systems, with two beams in the Gemini System and eight beams in the Helios System, this is particularly important. The LASL Helios CO2 Laser Fusion System has eight 34-cm diameter beams emerging from the power amplifier and each beam is brought to focus by an off-aperture parabola (nearly 77.3-cm focal length) resulting in a nearly F/2.4 beam at the focal plane. The design tolerance at the focal plane for pointing accuracy is +/- 25 microns and for focusing accuracy is +/- 50 microns for this system. This paper describes an alignment scheme based on the use of the infrared Smartt interferometer' and compares the results obtained using this technique and the autocollimating Hartmann scheme2 in a laboratory setup duplicating the target chamber region of one of the beams of the Helios System. The results using the Smartt interferometer show that pointing accuracy of +/- 12.5 microns and focusing accuracies of ± 15 microns are obtained at the focal plane of the system.

  5. Generation of tunable laser sidebands in the far-infrared region

    NASA Technical Reports Server (NTRS)

    Farhoomand, J.; Frerking, M. A.; Pickett, H. M.; Blake, G. A.

    1985-01-01

    In recent years, several techniques have been developed for the generation of tunable coherent radiation at submillimeter and far-infrared (FIR) wavelengths. The harmonic generation of conventional microwave sources has made it possible to produce spectrometers capable of continuous operation to above 1000 GHz. However, the sensitivity of such instruments drops rapidly with frequency. For this reason, a great deal of attention is given to laser-based methods, which could cover the entire FIR region. Tunable FIR radiation (approximately 100 nW) has been produced by mixing FIR molecular lasers and conventional microwave sources in both open and closed mixer mounts. The present investigation is concerned with improvements in this approach. These improvements provide approximately thirty times more output power than previous results.

  6. Three-dimensional direct cell patterning in collagen hydrogels with near-infrared femtosecond laser

    PubMed Central

    Hribar, Kolin C.; Meggs, Kyle; Liu, Justin; Zhu, Wei; Qu, Xin; Chen, Shaochen

    2015-01-01

    We report a methodology for three-dimensional (3D) cell patterning in a hydrogel in situ. Gold nanorods within a cell-encapsulating collagen hydrogel absorb a focused near-infrared femtosecond laser beam, locally denaturing the collagen and forming channels, into which cells migrate, proliferate, and align in 3D. Importantly, pattern resolution is tunable based on writing speed and laser power, and high cell viability (>90%) is achieved using higher writing speeds and lower laser intensities. Overall, this patterning technique presents a flexible direct-write method that is applicable in tissue engineering systems where 3D alignment is critical (such as vascular, neural, cardiac, and muscle tissue). PMID:26603915

  7. Laser System for Photoelectron and X-Ray Production in the PLEIADES Compton Light Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gibson, D J; Barty, C J; Betts, S M

    2005-04-21

    The PLEIADES (Picosecond Laser-Electron Interaction for the Dynamic Evaluation of Structures) facility provides tunable short x-ray pulses with energies of 30-140 keV and pulse durations of 0.3-5 ps by scattering an intense, ultrashort laser pulse off a 35-75 MeV electron beam. Synchronization of the laser and electron beam is obtained by using a photoinjector gun, and using the same laser system to generate the electrons and the scattering laser. The Ti Ti:Sapphire, chirped pulse amplification based 500 mJ, 50 fs, 810 nm scattering laser and the similar 300 {micro}J, 5 ps, 266 nm photoinjector laser systems are detailed. Additionally, anmore » optical parametric chirped pulse amplification (OPCPA) system is studied as a replacement for part of the scattering laser front end. Such a change would significantly simplify the set-up the laser system by removing the need for active switching optics, as well as increase the pre-pulse contrast ratio which will be important when part of the scattering laser is used as a pump beam in pump-probe diffraction experiments using the ultrashort tunable x-rays generated as the probe.« less

  8. Fiber lasers and their applications [Invited].

    PubMed

    Shi, Wei; Fang, Qiang; Zhu, Xiushan; Norwood, R A; Peyghambarian, N

    2014-10-01

    Fiber lasers have seen progressive developments in terms of spectral coverage and linewidth, output power, pulse energy, and ultrashort pulse width since the first demonstration of a glass fiber laser in 1964. Their applications have extended into a variety of fields accordingly. In this paper, the milestones of glass fiber laser development are briefly reviewed and recent advances of high-power continuous wave, Q-switched, mode-locked, and single-frequency fiber lasers in the 1, 1.5, 2, and 3 μm regions and their applications in such areas as industry, medicine, research, defense, and security are addressed in detail.

  9. High precision and high aspect ratio laser drilling: challenges and solutions

    NASA Astrophysics Data System (ADS)

    Uchtmann, Hermann; He, Chao; Gillner, Arnold

    2016-03-01

    Laser drilling is a very versatile tool to produce high accuracy bores in small and large geometries using different technologies. In large and deep hole drilling laser drilling can be found in drilling cooling holes into turbomachinery components such as turbine blades. In micro drilling, the technology is used for the generation of nozzles and filters. However, especially in macro drilling, the process often causes microstructure changes and induces defects such as recast layers and cracks. The defects are caused by the melt dominated drilling process by using pulse durations in the range of some 100 μm up to a few ms. A solution of this problem is the use of ultrashort pulsed laser radiation with pulse durations in the range of some 100 fs up to a few ps, however with the disadvantage of long drilling times. Thus, the aim of this work is to combine the productive process by using ms pulsed fiber laser radiation with subsequent ablation of existing recast layers at the hole wall by using ultrashort pulsed laser radiation. By using fast scanning techniques the recast layer can be avoided almost completely. With a similar technology also very small hole can be produced. Using a rotating dove prism a circular oscillation of the laser spots is performed and holes are drilled at intervals in 1 mm thick stainless steel (1.4301) by ultra-short laser pulses of 7 ps at 515 nm. The formation of hole and the behavior of energy deposition differ from other drilling strategies due to the helical revolution. The temporal evolution of the hole shape is analyzed by means of SEM techniques from which three drilling phases can be distinguished.

  10. Low power infrared laser modifies the morphology of lung affected with acute injury induced by sepsis

    NASA Astrophysics Data System (ADS)

    Sergio, L. P. S.; Trajano, L. A. S. N.; Thomé, A. M. C.; Mencalha, A. L.; Paoli, F.; Fonseca, A. S.

    2018-06-01

    Acute lung injury (ALI) is a potentially fatal disease characterized by uncontrolled hyperinflammatory responses in the lungs as a consequence of sepsis. ALI is divided into two sequential and time-dependent phases, exudative and fibroproliferative phases, with increased permeability of the alveolar barrier, causing edema and inflammation. However, there are no specific treatments for ALI. Low-power lasers have been successfully used in the resolution of acute inflammatory processes. The aim of this study was to evaluate the effects of low-power infrared laser exposure on alveolus and interalveolar septa of Wistar rats affected by ALI-induced by sepsis. Laser fluences, power, and the emission mode were those used in clinical protocols for the treatment of acute inflammation. Adult male Wistar rats were randomized into six groups: control, 10 J cm‑2, 20 J cm‑2, ALI, ALI  +  10 J cm‑2, and ALI  +  20 J cm‑2. ALI was induced by intraperitoneal Escherichia coli lipopolysaccharide (LPS). Lungs were removed and processed for hematoxylin–eosin staining. Morphological alterations induced by LPS in lung tissue were quantified by morphometry with a 32-point cyclic arcs test system in Stepanizer. Data showed that exposure to low-power infrared laser in both fluences reduced the thickening of interalveolar septa in lungs affected by ALI, increasing the alveolar space; however, inflammatory infiltrate was still observed. Our research showed that exposure to low-power infrared laser improves the lung parenchyma in Wistar rats affected by ALI, which could be an alternative approach for treatment of inflammatory lung injuries.

  11. Thomson-backscattered x rays from laser-accelerated electrons.

    PubMed

    Schwoerer, H; Liesfeld, B; Schlenvoigt, H-P; Amthor, K-U; Sauerbrey, R

    2006-01-13

    We present the first observation of Thomson-backscattered light from laser-accelerated electrons. In a compact, all-optical setup, the "photon collider," a high-intensity laser pulse is focused into a pulsed He gas jet and accelerates electrons to relativistic energies. A counterpropagating laser probe pulse is scattered from these high-energy electrons, and the backscattered x-ray photons are spectrally analyzed. This experiment demonstrates a novel source of directed ultrashort x-ray pulses and additionally allows for time-resolved spectroscopy of the laser acceleration of electrons.

  12. Ultrashort Laser Retinal Damage Threshold Mechanisms

    DTIC Science & Technology

    2010-01-15

    epithelium . Below one nanosecond both stress-confinement in melanosomes and self-focusing reduce the threshold for damage as measured in corneal radiant... epithelium (RPE). Below 1 ns, both stress confinement in melanosomes and self-focusing reduce the threshold for damage as measured in corneal radiant...collimated laser light is focused to a very small spot on the retina. The retinal pigment epithelium (RPE) contains melanosomes, which are the primary

  13. Partial ablation of Ti/Al nano-layer thin film by single femtosecond laser pulse

    NASA Astrophysics Data System (ADS)

    Gaković, B.; Tsibidis, G. D.; Skoulas, E.; Petrović, S. M.; Vasić, B.; Stratakis, E.

    2017-12-01

    The interaction of ultra-short laser pulses with Titanium/Aluminium (Ti/Al) nano-layered thin film was investigated. The sample composed of alternating Ti and Al layers of a few nanometres thick was deposited by ion-sputtering. A single pulse irradiation experiment was conducted in an ambient air environment using focused and linearly polarized femtosecond laser pulses for the investigation of the ablation effects. The laser induced morphological changes and the composition were characterized using several microscopy techniques and energy dispersive X-ray spectroscopy. The following results were obtained: (i) at low values of pulse energy/fluence, ablation of the upper Ti layer only was observed; (ii) at higher laser fluence, a two-step ablation of Ti and Al layers takes place, followed by partial removal of the nano-layered film. The experimental observations were supported by a theoretical model accounting for the thermal response of the multiple layered structure upon irradiation with ultra-short laser pulses.

  14. Far-infrared laser magnetic resonance of vibrationally excited CD2

    NASA Technical Reports Server (NTRS)

    Evenson, K. M.; Sears, T. J.; Mckellar, A. R. W.

    1984-01-01

    The detection of 13 rotational transitions in the first excited bending state (010) of CD2 using the technique of far-infrared laser magnetic resonance spectroscopy is reported. Molecular parameters for this state are determined from these new data together with existing infrared observations of the v(2) band. Additional information on the ground vibrational state (000) is also provided by the observation of a new rotational transition, and this is combined with existing data to provide a refined set of molecular parameters for the CD2 ground state. One spectrum has been observed that is assigned as a rotational transition within the first excited symmetric stretching state (100) of CD2. These data will be of use in refining the structure and the potential function of the methylene radical.

  15. The method for scanning reshaping the spectrum of chirped laser pulse based on the quadratic electro-optic effects

    NASA Astrophysics Data System (ADS)

    Ye, Rong; Yin, Ming; Wu, Xianyun; Tan, Hang

    2017-10-01

    T A new method for scanning reshaping the spectrum of chirped laser pulse based on quadratic electro-optic effects is proposed. The scanning reshaping scheme with a two-beam interference system is designed and the spectrum reshaping properties are analyzed theoretically. For the Gaussian chirped laser pulse with central wavelength λ0=800nm, nearly flat-topped spectral profiles with wider bandwidth is obtained with the proposed scanning reshaping method, which is beneficial to compensate for the gain narrowing effect in CPA and OPCPA. Further numerical simulations show that the reshaped spectrum is sensitive to the time-delay and deviation of the voltage applied to the crystal. In order to avoid narrowing or distorting the reshaped spectrum pointing to target, it is necessary to reduce the unfavorable deviations. With the rapid and wide applications of ultra-short laser pulse supported by some latter research results including photo-associative formation of ultra-cold molecules from ultra-cold atoms[1-3], laser-induced communications[4], capsule implosions on the National Ignition Facility(NIF)[5-6], the control of the temporal and spectral profiles of laser pulse is very important and urgently need to be addressed. Generally, the control of the pulse profiles depends on practical applications, ranging from femtosecond and picosecond to nanosecond. For instance, the basic shaping setup is a Fourier transform system for ultra-short laser pulse. The most important element is a spatially patterned mask which modulates the phase or amplitude, or sometimes the polarization after the pulse is decomposed into its constituent spectral components by usually a grating and a lens[7]. One of the generation techniques of ultra-short laser pulse is the chirped pulse amplifications(CPA), which brings a new era of development for high energy and high peak intensity ultra-short laser pulse, proposed by D. Strcik and G. Mourou from the chirping radar technology in microwave region

  16. Development of long wavelength semiconductor diode lasers near 28 microns for use in infrared heterodyne spectrometers

    NASA Technical Reports Server (NTRS)

    Linden, K. J.

    1984-01-01

    The development of tunable diode lasers operating in the 28 micrometers spectral region for use in infrared heterodyne spectrometers is reported. A process capable of yielding lasers emitting 500 micron W of multimode power, 112 micron W in a true single mode and true single mode operation at laser currents of up to 35% above threshold was developed. Results were obtained from narrow mesastripe (20 micrometer wide) short cavity (120 micrometer length) laser configurations. Six stripe geometry lasers, with a variety of cavity widths and lengths were delivered. The techniques to fabricate such devices was obtained and the long term reliability of such lasers by reproducible electrical and optical output characteristics fabrication from lasers are demonstrated.

  17. In-well pumped mid-infrared PbTe/CdTe quantum well vertical external cavity surface emitting lasers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Khiar, A., E-mail: amir.khiar@jku.at; Witzan, M.; Hochreiner, A.

    2014-06-09

    Optical in-well pumped mid-infrared vertical external cavity surface emitting lasers based on PbTe quantum wells embedded in CdTe barriers are realized. In contrast to the usual ternary barrier materials of lead salt lasers such as PbEuTe of PbSrTe, the combination of narrow-gap PbTe with wide-gap CdTe offers an extremely large carrier confinement, preventing charge carrier leakage from the quantum wells. In addition, optical in-well pumping can be achieved with cost effective and readily available near infrared lasers. Free carrier absorption, which is a strong loss mechanism in the mid-infrared, is strongly reduced due to the insulating property of CdTe. Lasingmore » is observed from 85 K to 300 K covering a wavelength range of 3.3–4.2 μm. The best laser performance is achieved for quantum well thicknesses of 20 nm. At low temperature, the threshold power is around 100 mW{sub P} and the output power more than 700 mW{sub P}. The significance of various charge carrier loss mechanisms are analyzed by modeling the device performance. Although Auger losses are quite low in IV–VI semiconductors, an Auger coefficient of C{sub A} = 3.5 × 10{sup −27} cm{sup 6} s{sup −1} was estimated for the laser structure, which is attributed to the large conduction band offset.« less

  18. Ultrashort pulsed laser technology development program

    NASA Astrophysics Data System (ADS)

    Manke, Gerald C.

    2014-10-01

    The Department of Navy has been pursuing a technology development program for advanced, all-fiber, Ultra Short Pulsed Laser (USPL) systems via Small Business Innovative Research (SBIR) programs. Multiple topics have been published to promote and fund research that encompasses every critical component of a standard USPL system and enable the demonstration of mJ/pulse class systems with an all fiber architecture. This presentation will summarize published topics and funded programs.

  19. Infrared laser thermal fusion of blood vessels: preliminary ex vivo tissue studies.

    PubMed

    Cilip, Christopher M; Rosenbury, Sarah B; Giglio, Nicholas; Hutchens, Thomas C; Schweinsberger, Gino R; Kerr, Duane; Latimer, Cassandra; Nau, William H; Fried, Nathaniel M

    2013-05-01

    Suture ligation of blood vessels during surgery can be time-consuming and skill-intensive. Energy-based, electrosurgical, and ultrasonic devices have recently replaced the use of sutures and mechanical clips (which leave foreign objects in the body) for many surgical procedures, providing rapid hemostasis during surgery. However, these devices have the potential to create an undesirably large collateral zone of thermal damage and tissue necrosis. We explore an alternative energy-based technology, infrared lasers, for rapid and precise thermal coagulation and fusion of the blood vessel walls. Seven near-infrared lasers (808, 980, 1075, 1470, 1550, 1850 to 1880, and 1908 nm) were tested during preliminary tissue studies. Studies were performed using fresh porcine renal vessels, ex vivo, with native diameters of 1 to 6 mm, and vessel walls flattened to a total thickness of 0.4 mm. A linear beam profile was applied normal to the vessel for narrow, full-width thermal coagulation. The laser irradiation time was 5 s. Vessel burst pressure measurements were used to determine seal strength. The 1470 nm laser wavelength demonstrated the capability of sealing a wide range of blood vessels from 1 to 6 mm diameter with burst strengths of 578 ± 154, 530 ± 171, and 426 ± 174  mmHg for small, medium, and large vessel diameters, respectively. Lateral thermal coagulation zones (including the seal) measured 1.0 ± 0.4  mm on vessels sealed at this wavelength. Other laser wavelengths (1550, 1850 to 1880, and 1908 nm) were also capable of sealing vessels, but were limited by lower vessel seal pressures, excessive charring, and/or limited power output preventing treatment of large vessels (>4  mm outer diameter).

  20. Demonstration of paper cutting using single emitter laser diode and infrared-absorbing ink.

    PubMed

    Pagès, Hubert; Piombini, Hervé; Enguehard, Franck; Acher, Olivier

    2005-04-04

    We show that conventional paper can be cut using a 1W laser diode, provided the cutting lines are first traced using a proper ink. The ink should absorb the laser light, and penetrate deep into the paper. An "invisible ink" that is transparent in the visible range and absorbing in the infrared has been successfully tested. The paper is tidily cut. The laser power required to cut the paper is proportional to the displacement speed of the paper. Cutting speeds exceeding 3 cm.s-1.W-1 have been demonstrated. At higher speeds, the paper is not cut through, but easy-tearable lines and easy-folding lines are obtained. The whole inking and laser cutting process may be integrated into next generations of personal inkjet printers and expand document creation abilities.

  1. Propagation of femtosecond laser pulses through water in the linear absorption regime.

    PubMed

    Naveira, Lucas M; Strycker, Benjamin D; Wang, Jieyu; Ariunbold, Gombojav O; Sokolov, Alexei V; Kattawar, George W

    2009-04-01

    We investigate the controversy regarding violations of the Bouguer-Lambert-Beer (BLB) law for ultrashort laser pulses propagating through water. By working at sufficiently low incident laser intensities, we make sure that any nonlinear component in the response of the medium is negligible. We measure the transmitted power and spectrum as functions of water cell length in an effort to confirm or disprove alleged deviations from the BLB law. We perform experiments at two different laser pulse repetition rates and explore the dependence of transmission on pulse duration. Specifically, we vary the laser pulse duration either by cutting its spectrum while keeping the pulse shape near transform-limited or by adjusting the pulses chirp while keeping the spectral intensities fixed. Over a wide range of parameters, we find no deviations from the BLB law and conclude that recent claims of BLB law violations are inconsistent with our experimental data. We present a simple linear theory (based on the BLB law) for propagation of ultrashort laser pulses through an absorbing medium and find our experimental results to be in excellent agreement with this theory.

  2. Laser Propulsion - Quo Vadis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bohn, Willy L.

    First, an introductory overview of the different types of laser propulsion techniques will be given and illustrated by some historical examples. Second, laser devices available for basic experiments will be reviewed ranging from low power lasers sources to inertial confinement laser facilities. Subsequently, a status of work will show the impasse in which the laser propulsion community is currently engaged. Revisiting the basic relations leads to new avenues in ablative and direct laser propulsion for ground based and space based applications. Hereby, special attention will be devoted to the impact of emerging ultra-short pulse lasers on the coupling coefficient andmore » specific impulse. In particular, laser sources and laser propulsion techniques will be tested in microgravity environment. A novel approach to debris removal will be discussed with respect to the Satellite Laser Ranging (SRL) facilities. Finally, some non technical issues will be raised aimed at the future prospects of laser propulsion in the international community.« less

  3. Ultrafast Laser Interaction Processes for LIBS and Other Sensing Technologies

    DTIC Science & Technology

    2013-04-05

    Propagation of ultrashort pulses through water, Optics Express, (02 2007): . doi: 12/02/2009 8.00 Z. Chen, S. Mao. Femtosecond laser -induced electronic...CO2 double- pulse laser -induced breakdown spectroscopy for explosive residues detection" SPIE Defense, Security, Sensing; Orlando, FL, USA; 04/07...Matthieu Baudelet, Michael Sigman, Paul J Dagdigian, Martin C. Richardson, "Nd:YAG-CO2 Double- Pulse Laser Induced Breakdown Spectroscopy for Explosive

  4. A Comparison of Microvascular Responses to Visible and Near-Infrared Lasers

    PubMed Central

    Li, D.; Farshidi, D.; Wang, G.X.; He, Y.L.; Kelly, K.M.; Wu, W.J.; Chen, B.; Ying, Z.X.

    2015-01-01

    Background and Objective Pulsed dye laser (PDL) is a commonly used treatment for Port Wine Stain birthmarks (PWS). However, deeper components of PWS are often resistant to PDL. Deeper penetrating lasers, including the long pulsed Neodymium:Yttrium Aluminum Garnet (Nd:YAG) laser have been used, but carry greater risk. This study evaluates the distinct blood vessel thermal responses to visible (595 nm) and near infrared (1,064 nm) lasers using animal and numerical models. Study Design/Materials and Methods Blood vessels in the rodent dorsal skin chamber (DSC) were irradiated by a 595 nm PDL and a long-pulsed 1,064 nm Nd:YAG laser. Laser-induced immediate and 1-hour post-structural and functional changes in the vessels were documented. Numerical simulations were conducted using a 1,000 μm depth SD mouse skin fold to simulate experimental conditions. Results PDL irradiation produced immediate blood vessel hemorrhage. Modeling indicated this occurs due to preferential heating of the superior parts of large blood vessels. Nd:YAG irradiation resulted in blood vessel constriction; modeling indicated more uniform heating of vessel walls. Conclusion PDL and Nd:YAG lasers result in distinct tissue responses. This supports different observable clinical treatment end points when using these devices. Vessel constriction associated with the Nd:YAG may be more difficult to observe and is one reason this device may carry greater risk. Lasers Surg. Med. 46:479–487, 2014. PMID:24974953

  5. The protozoan, Paramecium primaurelia, as a non-sentient model to test laser light irradiation: The effects of an 808nm infrared laser diode on cellular respiration.

    PubMed

    Amaroli, Andrea; Ravera, Silvia; Parker, Steven; Panfoli, Isabella; Benedicenti, Alberico; Benedicenti, Stefano

    2015-07-01

    Photobiomodulation (PBM) has been used in clinical practice for more than 40 years. Unfortunately, conflicting literature has led to the labelling of PBM as a complementary or alternative medicine approach. However, past and ongoing clinical and research studies by reputable investigators have re-established the merits of PBM as a genuine medical therapy, and the technique has, in the last decade, seen an exponential increase in the numbers of clinical instruments available, and their applications. This resurgence has led to a clear need for appropriate experimental models to test the burgeoning laser technology being developed for medical applications. In this context, an ethical model that employs the protozoan, Paramecium primaurelia, is proposed. We studied the possibility of using the measure of oxygen consumption to test PBM by irradiation with an infrared or near-infrared laser. The results show that an 808nm infrared laser diode (1W; 64J/cm²) affects cellular respiration in P. primaurelia, inducing, in the irradiated cells, a significantly (p < 0.05) increased oxygen consumption of about 40%. Our findings indicate that Paramecium can be an excellent tool in biological assays involving infrared and near-infrared PBM, as it combines the advantages of in vivo results with the practicality of in vitro testing. This test represents a fast, inexpensive and straightforward assay, which offers an alternative to both traditional in vivo testing and more expensive mammalian cellular cultures. 2015 FRAME.

  6. Fiber-delivered mid-infrared (6-7) laser ablation of retinal tissue under perfluorodecalin

    NASA Astrophysics Data System (ADS)

    Mackanos, Mark A.; Joos, Karen M.; Jansen, E. Duco

    2003-07-01

    The Er:YAG laser (l=2.94mm) is an effective tool in vitreo-retinal surgery. Pulsed mid-infrared (l=6.45 mm) radiation from the Free Electron Laser has been touted as a potentially superior cutting tool. To date, use of this laser has been limited to applications in an air environment. The goal of this study was: 1) determine feasibility of fiberoptic delivery of 6.45mm using silverhalide fibers (d=700mm); 2) use infrared transparent vitreous substitute (perfluorodecalin) to allow non-contact ablation of the retina at 6.45mm. Fiber damage threshold=7.8J/cm2 (0.54GW/cm2) while transmission loss=0.54dB/m, allowing supra-ablative radiant exposures to the target. FTIR measurements of perfluorodecalin at 6.45mm yielded ma=3mm-1. Pump-probe imaging of ablation of a tissue-phantom through perfluorodecalin showed feasibility of non-contact ablation at l=6.45mm. Ablation of the retinal membranes of enucleated pig eyes was carried out under perfluorodecalin (5 Hz, 1.3 J/cm2). Each eye was cut along its equator to expose the retina. Vitreous was replaced by perfluorodecalin and laser radiation was delivered to the retina via the silverhalide fiber. The eye was rotated (at 2 rpm) using a stepper motor (0.9o/step) to create an ablation circle around the central axis of the retina (50% spot-to-spot overlap). Histological analysis of ablation yield and collateral damage will be presented. We have shown that using l=6.45mm delivered via silver halide fibers through perfluorodecalin allowed non-contact laser ablation. Remote structures are shielded, as the radiant exposure falls below the ablation threshold owing non-negligible absorption of perfluorodecalin at 6.45mm. This may optimize efficacy and safety of laser-based vitreoretinal surgery.

  7. Effect of high-frequency near-infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats.

    PubMed

    Gunji, Hidemi; Kunimatsu, Ryo; Tsuka, Yuji; Yoshimi, Yuki; Sumi, Keisuke; Awada, Tetsuya; Nakajima, Kengo; Kimura, Aya; Hiraki, Tomoka; Hirose, Naoto; Yanoshita, Makoto; Tanimoto, Kotaro

    2018-02-05

    Tooth movement during orthodontic treatment is associated with bone neoplasticity and bone resorption on the tension and pressure sides. Previous clinical studies have suggested that low-power laser irradiation can accelerate tooth movement during orthodontic treatment, although the underlying mechanism remains unclear. In this study, we used a high-frequency near-infrared diode laser that generates less heat and examined the histologic changes in periodontal tissue during experimental tooth movement with laser irradiation. A nickel-titanium closed coil was mounted between the maxillary left side first molar and incisor of rats to model experimental tooth movement. The laser-irradiation and the control groups were set, and the amount of movement of the first molar on 7th and 14th days after the start of pulling of the first molar tooth on the maxillary left was measured by three-dimensional analysis of µCT. After tooth movement, tissue samples from the mesial and tension sides were collected, and successive horizontal sections were prepared and examined using hematoxylin-eosin and TRAP staining and immunohistochemical staining for RANKL, OPG, ALP, and proliferating cell nuclear antigen (PCNA). Changes in tissue temperature following laser irradiation were also examined. Laser irradiation significantly increased tooth movement compared with non-irradiated controls. Histologic staining of the pressure-side mesial root in laser-irradiated rats revealed enhanced RANKL expression and increased numbers of TRAP-positive cells compared with controls. By contrast, on the tension side, laser irradiation led to increased expression of ALP and PCNA. These data indicate that high-frequency near-infrared diode laser irradiation on the pressure side upregulates RANKL expression and accelerates osteoclast differentiation, facilitating bone resorption, whereas bone formation is induced on the tension side. This study demonstrates that high-frequency near-infrared diode laser

  8. High speed FPGA-based Phasemeter for the far-infrared laser interferometers on EAST

    NASA Astrophysics Data System (ADS)

    Yao, Y.; Liu, H.; Zou, Z.; Li, W.; Lian, H.; Jie, Y.

    2017-12-01

    The far-infrared laser-based HCN interferometer and POlarimeter/INTerferometer\\break (POINT) system are important diagnostics for plasma density measurement on EAST tokamak. Both HCN and POINT provide high spatial and temporal resolution of electron density measurement and used for plasma density feedback control. The density is calculated by measuring the real-time phase difference between the reference beams and the probe beams. For long-pulse operations on EAST, the calculation of density has to meet the requirements of Real-Time and high precision. In this paper, a Phasemeter for far-infrared laser-based interferometers will be introduced. The FPGA-based Phasemeter leverages fast ADCs to obtain the three-frequency signals from VDI planar-diode Mixers, and realizes digital filters and an FFT algorithm in FPGA to provide real-time, high precision electron density output. Implementation of the Phasemeter will be helpful for the future plasma real-time feedback control in long-pulse discharge.

  9. Mid-infrared InAs/AlGaSb superlattice quantum-cascade lasers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ohtani, K.; Fujita, K.; Ohno, H.

    2005-11-21

    We report on the demonstration of mid-infrared InAs/AlGaSb superlattice quantum-cascade lasers operating at 10 {mu}m. The laser structures are grown on n-InAs (100) substrate by solid-source molecular-beam epitaxy. An InAs/AlGaSb chirped superlattice structure providing a large oscillator strength and fast carrier depopulation is employed as the active part. The observed minimum threshold current density at 80 K is 0.7 kA/cm{sup 2}, and the maximum operation temperature in pulse mode is 270 K. The waveguide loss of an InAs plasmon waveguide is estimated, and the factors that determine the operation temperature are discussed.

  10. Effects of near infrared laser radiation associated with photoabsorbing cream in preventing white spot lesions around orthodontic brackets: an in vitro study.

    PubMed

    Lacerda, Ângela Sueli Soares Braga; Hanashiro, Fernando Seishim; de Sant'Anna, Giselle Rodrigues; Steagall Júnior, Washington; Barbosa, Patrícia Silva; de Souza-Zaroni, Wanessa Christine

    2014-12-01

    The present study aims to investigate the effect of a low-power infrared laser on the inhibition of bovine enamel demineralization around orthodontic brackets. Near infrared lasers have been suggested as alternative approaches because they may produce an increase in resistance to dental caries. Forty-eight blocks of enamel obtained from bovine incisor teeth were divided into six groups: Group 1 (control), without treatment; Group 2 (C), photoabsorbing cream; Group 3 (CF), photoabsorbing cream with fluoride; Group 4 (L), irradiation with low-level infrared laser (λ=830 nm) at an energy density of 4.47 J/cm2; Group 5 (L+C), photoabsorbing cream followed by low-level infrared laser irradiation; and Group 6 (L+CF), photoabsorbing cream with fluoride followed by low-level infrared laser irradiation. After these procedures, the enamel blocks received an assortment of orthodontic brackets and were then submitted to pH cycling to simulate a highly cariogenic challenge. The enamel surface demineralization around the orthodontic brackets, according to the different treatments, was quantified by fluorescence loss analysis by quantitative light-induced fluorescence (QLF). The fluorescence loss, expressed as ΔF (percentage of loss fluorescence), was statistically examined by analysis of variance and the Tukey test. The control group (-10.48±2.85) was statistically similar to Group C (-14.52±7.80), which presented the lowest values of ΔF when compared with Groups FC (-3.67±3.21), L (-2.79±1.68), CL (-1.05±0:50), and CFL (-0.60±0:43). However, Groups FC, L, CL, and CFL showed no statistically significant differences among them. It can be concluded that both the low-level infrared laser and photoabsorbing cream with fluoride were effective in inhibiting the development of caries in enamel around orthodontic brackets, even in situations of high cariogenic challenge.

  11. Influence of laser frequency chirp on deuteron energy from laser-driven deuterated methane cluster expansion

    NASA Astrophysics Data System (ADS)

    Li, H. Y.; Liu, J. S.

    2010-06-01

    The simulations of three-dimensional particle dynamics are carried out to investigate the Coulomb explosion dynamics of deuterated methane clusters under the irradiation of an ultrashort intense laser pulse. The final kinetic energy of deuterons produced from the cluster explosion is calculated as a function of the pulse width, the laser intensity and the pulse chirp. It is found that the deuteron energy obtained in an intense laser pulse with negative chirp is higher than that with positive chirp, which agrees qualitatively with the experimental results reported by Fukuda et al. [Y. Fukuda et al., Phys. Rev. A 67, 061201 (2003)].

  12. Laser-guided energetic discharges over large air gaps by electric-field enhanced plasma filaments

    NASA Astrophysics Data System (ADS)

    Théberge, Francis; Daigle, Jean-François; Kieffer, Jean-Claude; Vidal, François; Châteauneuf, Marc

    2017-01-01

    Recent works on plasma channels produced during the propagation of ultrashort and intense laser pulses in air demonstrated the guiding of electric discharges along the laser path. However, the short plasma lifetime limits the length of the laser-guided discharge. In this paper, the conductivity and lifetime of long plasma channels produced by ultrashort laser pulses is enhanced efficiently over many orders of magnitude by the electric field of a hybrid AC-DC high-voltage source. The AC electric pulse from a Tesla coil allowed to stimulate and maintain the highly conductive channel during few milliseconds in order to guide a subsequent 500 times more energetic discharge from a 30-kV DC source. This DC discharge was laser-guided over an air gap length of two metres, which is more than two orders of magnitude longer than the expected natural discharge length. Long plasma channel induced by laser pulses and stimulated by an external high-voltage source opens the way for wireless and efficient transportation of energetic current pulses over long air gaps and potentially for guiding lightning.

  13. Laser-guided energetic discharges over large air gaps by electric-field enhanced plasma filaments

    PubMed Central

    Théberge, Francis; Daigle, Jean-François; Kieffer, Jean-Claude; Vidal, François; Châteauneuf , Marc

    2017-01-01

    Recent works on plasma channels produced during the propagation of ultrashort and intense laser pulses in air demonstrated the guiding of electric discharges along the laser path. However, the short plasma lifetime limits the length of the laser-guided discharge. In this paper, the conductivity and lifetime of long plasma channels produced by ultrashort laser pulses is enhanced efficiently over many orders of magnitude by the electric field of a hybrid AC-DC high-voltage source. The AC electric pulse from a Tesla coil allowed to stimulate and maintain the highly conductive channel during few milliseconds in order to guide a subsequent 500 times more energetic discharge from a 30-kV DC source. This DC discharge was laser-guided over an air gap length of two metres, which is more than two orders of magnitude longer than the expected natural discharge length. Long plasma channel induced by laser pulses and stimulated by an external high-voltage source opens the way for wireless and efficient transportation of energetic current pulses over long air gaps and potentially for guiding lightning. PMID:28053312

  14. Femtosecond Mode-locked Fiber Laser at 1 μm Via Optical Microfiber Dispersion Management.

    PubMed

    Wang, Lizhen; Xu, Peizhen; Li, Yuhang; Han, Jize; Guo, Xin; Cui, Yudong; Liu, Xueming; Tong, Limin

    2018-03-16

    Mode-locked Yb-doped fiber lasers around 1 μm are attractive for high power applications and low noise pulse train generation. Mode-locked fiber lasers working in soliton and stretched-pulse regime outperform others in terms of the laser noise characteristics, mechanical stability and easy maintenance. However, conventional optical fibers always show a normal group velocity dispersion around 1 μm, leading to the inconvenience for necessary dispersion management. Here we show that optical microfibers having a large anomalous dispersion around 1 μm can be integrated into mode-locked Yb-doped fiber lasers with ultralow insertion loss down to -0.06 dB, enabling convenient dispersion management of the laser cavity. Besides, optical microfibers could also be adopted to spectrally broaden and to dechirp the ultrashort pulses outside the laser cavity, giving rise to a pulse duration of about 110 fs. We believe that this demonstration may facilitate all-fiber format high-performance ultrashort pulse generation at 1 μm and may find applications in precision measurements, large-scale facility synchronization and evanescent-field-based optical sensing.

  15. Heuristic modelling of laser written mid-infrared LiNbO3 stressed-cladding waveguides.

    PubMed

    Nguyen, Huu-Dat; Ródenas, Airán; Vázquez de Aldana, Javier R; Martínez, Javier; Chen, Feng; Aguiló, Magdalena; Pujol, Maria Cinta; Díaz, Francesc

    2016-04-04

    Mid-infrared lithium niobate cladding waveguides have great potential in low-loss on-chip non-linear optical instruments such as mid-infrared spectrometers and frequency converters, but their three-dimensional femtosecond-laser fabrication is currently not well understood due to the complex interplay between achievable depressed index values and the stress-optic refractive index changes arising as a function of both laser fabrication parameters, and cladding arrangement. Moreover, both the stress-field anisotropy and the asymmetric shape of low-index tracks yield highly birefringent waveguides not useful for most applications where controlling and manipulating the polarization state of a light beam is crucial. To achieve true high performance devices a fundamental understanding on how these waveguides behave and how they can be ultimately optimized is required. In this work we employ a heuristic modelling approach based on the use of standard optical characterization data along with standard computational numerical methods to obtain a satisfactory approximate solution to the problem of designing realistic laser-written circuit building-blocks, such as straight waveguides, bends and evanescent splitters. We infer basic waveguide design parameters such as the complex index of refraction of laser-written tracks at 3.68 µm mid-infrared wavelengths, as well as the cross-sectional stress-optic index maps, obtaining an overall waveguide simulation that closely matches the measured mid-infrared waveguide properties in terms of anisotropy, mode field distributions and propagation losses. We then explore experimentally feasible waveguide designs in the search of a single-mode low-loss behaviour for both ordinary and extraordinary polarizations. We evaluate the overall losses of s-bend components unveiling the expected radiation bend losses of this type of waveguides, and finally showcase a prototype design of a low-loss evanescent splitter. Developing a realistic waveguide

  16. Novel materials as potential infrared laser hosts

    NASA Astrophysics Data System (ADS)

    Sarkies, Julian Richard

    The work presented in this thesis has concentrated on an assessment and characterisation of potential laser host media which will only support low phonon or vibrational modes. This is a necessary criterion if systems in which the active ions are lanthanides are to be made to lase in the mid-infrared, as in conventional host media non- radiative processes dominate transitions in this region. Research has concentrated upon two main areas. Firstly a spectroscopic study of lanthanide doped PBr3/AlBr3/SbBr3 was undertaken. A detailed investigation and characterisation of the stable solution formation region was carried out. The doping levels achievable were seen to vary across the lanthanide series from a maximum 0.24mol% for praesodymium to a minimum 0.15mol% for ytterbium. Energies of the characteristic 4 f absorptions of the trivalent lanthanides were measured, along with their oscillator strengths. Judd-Ofelt parameters were found for several rare earths. Stimulated emission cross sections were found to be higher than in conventional glass hosts for certain transitions, such as 6.83 × 10 -20 cm2 for the 4F3/2 --> 4I11/2 transition in the Nd3+ doped liquid. This was verified both experimentally and by the Ladenburg-Fuchtbauer relation when compared to a standard silicate glass. The behaviour, both spectroscopic and physical, of the doped solutions was seen to change dramatically upon heating. Heating the solutions gave rise to higher crystallisation rates, but lower non-radiative relaxation rates. Waveguide and laser experiments were attempted in both bulk and capillary geometries, however material factors such as crystallisation and thermal lensing prevented laser action. Secondly, rare earth doped planar waveguides of zinc sulphide were prepared. A full characterisation of the way in which waveguide loss was affected by factors such as deposition rate, doping level and waveguide masking during evaporation was performed. Waveguide losses as low as 1.5dB/cm at 980nm

  17. Infrared scanning laser ophthalmoscope imaging of the macula and its correlation with functional loss and structural changes in patients with stargardt disease.

    PubMed

    Anastasakis, Anastasios; Fishman, Gerald A; Lindeman, Martin; Genead, Mohamed A; Zhou, Wensheng

    2011-05-01

    To correlate the degree of functional loss with structural changes in patients with Stargardt disease. Eighteen eyes of 10 patients with Stargardt disease were studied. Scanning laser ophthalmoscope infrared images were compared with corresponding spectral-domain optical coherence tomography scans. Additionally, scanning laser ophthalmoscope microperimetry was performed, and results were superimposed on scanning laser ophthalmoscope infrared images and in selected cases on fundus autofluorescence images. Seventeen of 18 eyes showed a distinct hyporeflective foveal and/or perifoveal area with distinct borders on scanning laser ophthalmoscope infrared images, which was less evident on funduscopy and incompletely depicted in fundus autofluorescence images. This hyporeflective zone corresponded to areas of significantly elevated psychophysical thresholds on microperimetry testing, in addition to thinning of the retinal pigment epithelium and disorganization or loss of the photoreceptor cell inner segment-outer segment junction and external-limiting membrane on spectral-domain optical coherence tomography. Scanning laser ophthalmoscope infrared fundus images are useful for depicting retinal structural changes in patients with Stargardt disease. A spectral-domain optical coherence tomography/scanning laser ophthalmoscope microperimetry device allows for a direct correlation of structural abnormalities with functional defects that will likely be applicable for the determination of retinal areas for potential improvement of retinal function in these patients during future clinical trials and for the monitoring of the diseases' natural history.

  18. Black phosphorus saturable absorber for a diode-pumped passively Q-switched Er:CaF2 mid-infrared laser

    NASA Astrophysics Data System (ADS)

    Li, Chun; Liu, Jie; Guo, Zhinan; Zhang, Han; Ma, Weiwei; Wang, Jingya; Xu, Xiaodong; Su, Liangbi

    2018-01-01

    A multilayer black phosphorus, as a novel two dimensional saturable absorber, has superb saturable absorption properties for a Er:CaF2 solid-state pulse laser. The pulse laser is realized at mid-infrared region with the passively Q-switched technology by a diode-pumping. The high-quality black phosphorus saturable absorber is fabricated by liquid phase exfoliation method. The pulse laser generates the pulses operation with the pulse duration of 954.8 ns, the repetition rate of 41.93 kHz, the pulse energy of 4.25 μJ and the peak power of 4.45 W. Our work demonstrates that black phosphorus could be used as a kind of efficient mid-infrared region optical absorber for ultrafast photonics.

  19. Correlated multielectron dynamics in mid-infrared laser pulse interactions with neon atoms.

    PubMed

    Tang, Qingbin; Huang, Cheng; Zhou, Yueming; Lu, Peixiang

    2013-09-09

    The multielectron dynamics in nonsequential triple ionization (NSTI) of neon atoms driven by mid-infrared (MIR) laser pulses is investigated with the three-dimensional classical ensemble model. In consistent with the experimental result, our numerical result shows that in the MIR regime, the triply charged ion longitudinal momentum spectrum exhibits a pronounced double-hump structure at low laser intensity. Back analysis reveals that as the intensity increases, the responsible triple ionization channels transform from direct (e, 3e) channel to the various mixed channels. This transformation of the NSTI channels leads to the results that the shape of ion momentum spectra becomes narrow and the distinct maxima shift towards low momenta with the increase of the laser intensity. By tracing the triply ionized trajectories, the various ionization channels at different laser intensities are clearly identified and these results provide an insight into the complex dynamics of the correlated three electrons in NSTI.

  20. Design of an infrared camera based aircraft detection system for laser guide star installations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Friedman, H.; Macintosh, B.

    1996-03-05

    There have been incidents in which the irradiance resulting from laser guide stars have temporarily blinded pilots or passengers of aircraft. An aircraft detection system based on passive near infrared cameras (instead of active radar) is described in this report.