Sample records for um centro urbano

  1. Study of the Local Horizon. (Spanish Title: Estudio del Horizonte Local.) Estudo do Horizonte Local

    NASA Astrophysics Data System (ADS)

    Ros, Rosa M.

    2009-12-01

    The study of the horizon is fundamental to easy the first observations of the students at any education center. A simple model, to be developed in each center, allows to easy the study and comprehension of the rudiments of astronomy. The constructed model is presented in turn as a simple equatorial clock, other models (horizontal and vertical) may be constructed starting from it. El estudio del horizonte es fundamental para poder facilitar las primeras observaciones de los alumnos en un centro educativo. Un simple modelo, que debe realizarse para cada centro, nos permite facilitar el estudio y la comprensión de los primeros rudimentos astronómicos. El modelo construido se presenta a su vez como un sencillo modelo de reloj ecuatorial y a partir de él se pueden construir otros modelos (horizontal y vertical). O estudo do horizonte é fundamental para facilitar as primeiras observações dos alunos num centro educativo. Um modelo simples, que deve ser feito para cada centro, permite facilitar o estudo e a compreensão dos primeiros rudimentos astronômicos. O modelo construído apresenta-se, por sua vez, como um modelo simples de relógio equatorial e a partir dele pode-se construir outros modelos (horizontal e vertical)

  2. Centro de Divulgação da Astronomia - o Observatório de São Carlos

    NASA Astrophysics Data System (ADS)

    Dias, W. S.; Hönel, J.; Líbero, V. L.; Anderlini, A.; de Andrade, D.; Scatena, E.; Lazo, M. J.; Trevisan, M.; de Castro, V.

    2005-07-01

    Apresentamos as principais características do Centro de Divulgação da Astronomia, que é constituído e um observatório cujo objetivo é a divulgação da Astronomia junto à comunidade, através de palestras e de observação direta dos astros. Descrevemos, neste trabalho, as atividades desenvolvidas desde sua fundação em 1986, e mostramos sua importância na região através de números anuais das atividades realizadas.

  3. [In Process Citation].

    PubMed

    Cuerda, Cristina; Álvarez, Julia; Ramos, Primitivo; Abánades, Juan Carlos; García-de-Lorenzo, Abelardo; Gil, Pedro; De-la-Cruz, Juan José

    2016-03-25

    Introducción: la desnutrición relacionada con la enfermedad (DRE) es un problema sociosanitario frecuente que afecta preferentemente a los mayores de 65 años, que aumenta la morbimortalidad y disminuye la calidad de vida.  Objetivo: estudiar la prevalencia de DRE en mayores de 65 años en diferentes centros sociosanitarios del Servicio Regional de Bienestar Social de la Comunidad de Madrid. Métodos: estudio transversal en 33 centros sociosanitarios de Madrid (6 centros de atención primaria [AP], 9 centros de mayores [CM], 9 hospitales [H] y 9 residencias [R]) seleccionados mediante muestreo polietápico. Las variables estudiadas fueron edad, sexo, nivel de dependencia según la escala de incapacidad de la Cruz Roja, motivo de ingreso y enfermedad de base, hábitat (urbano-periurbano-rural) y distribución geográfica (norte centro-sur). Como herramienta de cribado nutricional se utilizó el Mini Nutritional Assessment (MNA-cribaje) en todos los centros. En los pacientes con cribado positivo (en riesgo-desnutrición) se realizó el MNA-evaluación. El estudio estadístico se realizó con el paquete SSS 21.0 e incluyó estadística descriptiva, test de Chi-cuadrado y prueba exacta de Fisher, ANOVA de un factor, Kruskal-Wallis y análisis de regresión logística (RL) binaria univariante y multivariante. Se consideró significación estadística p < 0,05. Resultados: se reclutaron 1.103 sujetos (275 AP, 278 CM, 281 H, 269 R), edad media de 79,5 ± 8,4 años (41,2% varones, 58,8% mujeres). Los sujetos procedentes de H y R tuvieron un mayor grado de incapacidad (p < 0,001). La prevalencia global de DRE fue del 10%, encontrándose un 23,3% en riesgo de desnutrición, con diferencias entre los cuatro tipos de centros sociosanitarios (p < 0,001). El análisis univariante de RL mostró diferencia significativas en la prevalencia de desnutrición según la edad, sexo, grado de dependencia, tipo de centro sociosanitario, hábitat y zona geográfica. Sin embargo, en el análisis multivariante solo el grado de dependencia, el tipo de centro y el hábitat tuvieron significación estadística. Conclusiones: la prevalencia de DRE en mayores de 65 años en la Comunidad de Madrid es del 10%, encontrándose además un 23,3% en riesgo de desnutrición. Las únicas variables que se relacionaron de forma independiente con la desnutrición en el análisis multivariante fueron el nivel de dependencia de los pacientes y el tipo y hábitat de centro sociosanitario.

  4. Transferências orbitais dentro do modelo quase bicircular no sistema Terra-Lua-Sol

    NASA Astrophysics Data System (ADS)

    Corrêa, A. A.; de Almeida Prado, A. F. B.; Stuchi, T. J.; Beaugé, C.

    2003-08-01

    O problema quase bicircular planar consiste na determinação da dinâmica de um corpo, de massa desprezível, que se move sob o campo gravitacional de três corpos. No caso estudado, o quarto corpo é considerado um satélite artificial e os demais são a Terra, a Lua e o Sol, formando o sistema de três corpos. Este modelo permite a construção de uma hamiltoniana similar a do problema restrito de três corpos (PRTC), incluindo termos periódicos não autônomos, provenientes da presença do Sol, portanto pode ser entendido como uma perturbação ao PRTC. Suas órbitas periódicas aparecem isoladas e possuem o mesmo período solar. Os pontos de equilíbrio colineares possuem o mesmo caráter de estabilidade linear dos pontos lagrangianos (L1, L2 e L3) do PRTC, sendo do tipo sela x centro x centro, instável na direção x e estáveis nas direções y e z. As órbitas periódicas tridimensionais ao redor do ponto colinear é chamada órbita Halo. O objetivo deste trabalho é determinar órbitas de transferências de baixo consumo de combustível para um veículo espacial partindo de uma órbita de estacionamento ao redor da Terra em direção a uma órbita Halo do ponto L1, situado entre a Terra e Lua. Esta tarefa pode ser transformada no problema de valor de contorno: dado um ponto inicial na órbita de estacionamento, um ponto final na órbita halo e o tempo de transferência, deseja-se obter a trajetória que liga estes dois pontos e que minimize os incrementos de velocidade do veículo. Essas transferências são realizadas baseadas no método de Lambert e analisadas de modo a fornecer um baixo consumo. Posteriormente, é feita uma comparação de consumo com as órbitas de transferência equivalentes do PRTC.

  5. Astronomia para/com crianças carentes em Limeira

    NASA Astrophysics Data System (ADS)

    Bretones, P. S.; Oliveira, V. C.

    2003-08-01

    Em 2001, o Instituto Superior de Ciências Aplicadas (ISCA Faculdades de Limeira) iniciou um projeto pelo qual o Observatório do Morro Azul empreendeu uma parceria com o Centro de Promoção Social Municipal (CEPROSOM), instituição mantida pela Prefeitura Municipal de Limeira para atender crianças e adolescentes carentes. O CEPROSOM contava com dois projetos: Projeto Centro de Convivência Infantil (CCI) e Programa Criança e Adolescente (PCA), que atendiam crianças e adolescentes em Centros Comunitários de diversas áreas da cidade. Esses projetos têm como prioridades estabelecer atividades prazerosas para as crianças no sentido de retirá-las das ruas. Assim sendo, as crianças passaram a ter mais um tipo de atividade - as visitas ao observatório. Este painel descreve as várias fases do projeto, que envolveu: reuniões de planejamento, curso de Astronomia para as orientadoras dos CCIs e PCAs, atividades relacionadas a visitas das crianças ao Observatório, proposta de construção de gnômons e relógios de Sol nos diversos Centros Comunitários de Limeira e divulgação do projeto na imprensa. O painel inclui discussões sobre a aprendizagem de crianças carentes, relatos que mostram a postura das orientadoras sobre a pertinência do ensino de Astronomia, relatos do monitor que fez o atendimento no Observatório e o que o número de crianças atendidas representou para as atividades da instituição desde o início de suas atividades e, em particular, em 2001. Os resultados são baseados na análise de relatos das orientadoras e do monitor do Observatório, registros de visitas e matérias da imprensa local. Conclui com uma avaliação do que tal projeto representou para as Instituições participantes. Para o Observatório, em particular, foi feita uma análise com relação às outras modalidades de atendimentos que envolvem alunos de escolas e público em geral. Também é abordada a questão do compromisso social do Observatório na educação do público em questão.

  6. Perfil das alterações vasculares periféricas em dependentes de crack acompanhados em Centro de Atenção Psicossocial para Álcool e Drogas (CAPS-AD)

    PubMed Central

    da Costa, Antônio Fagundes; Baldaçara, Leonardo Rodrigo; da Silva, Sílvio Alves; Tavares, Ana Célia de Freitas Ramos; Orsolin, Ederson de Freitas; Prehl, Vinícius Barros; Gondo, Fernando Hirohito Beltran; Santana, Hernani Lopes

    2016-01-01

    Resumo Contexto O consumo de crack é um dos grandes desafios em saúde pública, e o uso dessa droga tem efeitos diretos na saúde de seus usuários. Objetivos Avaliar o perfil das alterações vasculares em pacientes com dependência de crack em Centro de Atenção Psicossocial para Álcool e Drogas (CAPS-AD) e observar os possíveis efeitos vasculares periféricos. Métodos Trata-se de um estudo observacional, descritivo, de corte transversal. Os pacientes da amostra foram submetidos a um questionário objetivo para avaliar questões demográficas, padrão de uso da droga, coexistência de diabetes melito, hipertensão arterial ou tabagismo, exame físico e ecográfico. Os dados foram sumarizados e analisados estatisticamente com teste qui-quadrado ou teste exato de Fisher. Resultados A média de idade da amostra foi de 33,29 (±7,15) anos, e 74% eram do gênero masculino. A média de idade de início de uso da droga foi de 23,4 (±7,78) anos, com tempo médio de uso de 9,58 (±5,64) anos. O consumo médio diário de pedras de crack foi de 21,45 (±8,32) pedras. A alteração de pulsos em membros inferiores foi mais frequente em mulheres. A prevalência do espessamento da parede arterial nos membros inferiores foi de 94,8%. O tempo de uso da droga apresentou associação estatística (p = 0,0096) com alteração do padrão de curva espectral das artérias dos membros inferiores. Conclusões Há alterações vasculares periféricas em usuários de crack. O tempo de uso da droga exerceu um maior impacto nesse sistema, o que sugere associação entre o uso do crack e a diminuição de fluxo arterial.

  7. Uso de terreno urbano y rural en Puerto Rico

    Treesearch

    Sebastian Martinuzzi; William A. Gould; Olga M. Ramos Gonzalez; Maya Quinones; Michael E. Jimenez

    2008-01-01

    El Proyecto de Analisis de Gap de Puerto Rico (PRGAP) (Gould et al. 2008) desarrollo tres usos de terrenos para Puerto Rico: Urbano, Suburbano, y Rural (Martinuzzi et al. 2007). Estas regiones tambien pueden ser consideradas como urbano, densamente-poblado rural, y escasamente-poblado rural, o como urbano y area silvestre con una interfase de area silvestre-urbana. La...

  8. Astronomía en la cultura

    NASA Astrophysics Data System (ADS)

    López, A.; Giménez Benitez, S.; Fernández, L.

    La Astronomía en la Cultura es el estudio interdisciplinario a nivel global de la astronomía prehistórica, antigua y tradicional, en el marco de su contexto cultural. Esta disciplina abarca cualquier tipo de estudios o líneas de investigación en que se relacione a la astronomía con las ciencias humanas o sociales. En ella se incluyen tanto fuentes escritas, relatos orales como fuentes arqueológicas, abarcando entre otros, los siguientes temas: calendarios, observación práctica, cultos y mitos, representación simbólica de eventos, conceptos y objetos astronómicos, orientación astronómica de tumbas, templos, santuarios y centros urbanos, cosmología tradicional y la aplicación ceremonial de tradiciones astronómicas, la propia historia de la astronomía y la etnoastronomía (Krupp, 1989) (Iwaniszewski, 1994). En nuestro trabajo abordamos la historia y situación actual de esta disciplina, sus métodos y sus relaciones con otras áreas de investigación.

  9. Sweat test and cystic fibrosis: overview of test performance at public and private centers in the state of São Paulo, Brazil.

    PubMed

    Servidoni, Maria Fátima; Gomez, Carla Cristina Souza; Marson, Fernando Augusto Lima; Toro, Adyléia Aparecida Dalbo Contrera; Ribeiro, Maria Ângela Gonçalves de Oliveira; Ribeiro, José Dirceu; Ribeiro, Antônio Fernando

    2017-01-01

    The sweat test (ST) measures chloride levels in sweat and is considered the gold standard for the diagnosis of cystic fibrosis (CF). However, the reliability of a ST depends on their being performed by experienced technicians and in accordance with strict guidelines. Our aim was to evaluate how sweat stimulation, sweat collection, and chloride measurement are performed at 14 centers (9 public centers and 5 private centers) that routinely perform STs in the state of São Paulo, which has the highest frequency of CF in Brazil. This was a cross-sectional cohort study, using a standardized questionnaire administered in loco to the staff responsible for conducting STs. No uniformity regarding the procedures was found among the centers. Most centers were noncompliant with the international guidelines, especially regarding the collection of sweat (the samples were insufficient in 10-50% of the subjects tested); availability of stimulation equipment (which was limited at 2 centers); modernity and certification of stimulation equipment (most of the equipment having been used for 3-23 years); and written protocols (which were lacking at 12 centers). Knowledge of ST guidelines was evaluated at only 1 center. Our results show that STs largely deviate from internationally accepted guidelines at the participating centers. Therefore, there is an urgent need for standardization of STs, training of qualified personnel, and acquisition/certification of suitable equipment. These are essential conditions for a reliable diagnosis of CF, especially with the increasing demand due to newborn screening nationwide, and for the assessment of a possible clinical benefit from the use of modulator drugs. O teste do suor (TS) mede os níveis de cloro no suor e é considerado o padrão ouro para o diagnóstico da fibrose cística (FC). Contudo, a confiabilidade do TS depende de sua realização por técnicos experientes e segundo diretrizes rígidas. Nosso objetivo foi avaliar como são realizadas a estimulação e coleta do suor e a dosagem de cloro em 14 centros (9 públicos e 5 privados) que realizam TS rotineiramente no estado de São Paulo, que possui a maior frequência de FC do Brasil. Estudo de coorte transversal utilizando um questionário padronizado aplicado in loco ao pessoal responsável pela realização dos TS. Não houve uniformidade entre os centros quanto aos procedimentos. A maioria dos centros não era aderente às diretrizes internacionais, especialmente quanto à coleta do suor (amostras insuficientes em 10-50% dos indivíduos testados), disponibilidade de equipamentos de estimulação (limitada em 2 centros), modernidade e certificação dos mesmos (a maioria utilizada há 3-23 anos) e protocolos escritos (ausentes em 12 centros). Avaliou-se o conhecimento sobre diretrizes para TS em apenas 1 centro. Nossos resultados mostram que, nos centros participantes, os TS estão muito distantes das diretrizes internacionalmente aceitas. Portanto, há necessidade urgente de padronização dos TS, de treinamento de pessoal qualificado e de aquisição/certificação de equipamentos adequados. Essas são condições essenciais para um diagnóstico confiável de FC, especialmente com a crescente demanda resultante da triagem neonatal em todo o país, e para a avaliação do possível benefício clínico do uso de moduladores.

  10. Systemic Arterial Hypertension in Patients Exposed to Cesium-137 in Goiânia-GO: Prevalence Study.

    PubMed

    Rodrigues, José Victor Rabelo; Pinto, Murillo Macêdo; Figueredo, Roberto Miller Pires; Lima, Helen de; Souto, Rafael; Sacchetim, Sylvana de Castro

    2017-01-01

    Systemic Arterial Hypertension (SAH) in the Brazilian population, in populations not exposed to Césio-137, presents a prevalence of 28% nationwide. However, in the group of radioactivity victims, these values are unknown. To analyze the prevalence of hypertension in patients exposed to Cesium-137 in Goiânia, enrolled in the Sistema de Monitoramento dos Radioacidentados (SISRAD) (Radioactivtity Victims Monitoring System) of the Centro de Assistência aos Radioacidentados (C.A.R.A) (Assistence Center for Radioactivity Victims). This is a descriptive, observational cross-sectional epidemiological study carried out in Goiânia-Goiás, from August 2013 to October 2014, with a group of patients enrolled in the Sistema de Monitoramento dos Radioacidentados (SISRAD) of the Centro de Assistência a Radioacidentados (C.A.R.A.). A total of 102 radioactive patients were divided into two groups: group 1 with 40 and group 2 with 62 participants. A field survey was conducted with a closed and semi-structured questionnaire in which the following contexts were addressed: sociodemographic profile, life habits and personal background. A database was created using the Google Forms application from the Google Web technologies company. The duly collected and stored data were imported and analyzed in the statistical software SPSS, version 21. The prevalence of SAH reached a total of 25% (12 individuals) of the 48 interviewees, 50% of women (24) and 50% of men (24), of which 22.9% (11) of the radioactivity victims revealed to be smokers. The prevalence of SAH in the radioactivity victims population is similar to that of the population in general. A Hipertensão Arterial Sistêmica (HAS) na população brasileira, em populações não expostas ao Césio-137, apresenta prevalência de 28% em âmbito nacional. Porém, no grupo de radioacidentados, esses valores são desconhecidos. Analisar a prevalência da HAS em pacientes expostos ao Césio-137 ocorrido em Goiânia, cadastrados no Sistema de Monitoramento dos Radioacidentados (SISRAD) do Centro de Assistência aos Radioacidentados (C.A.R.A). Estudo epidemiológico do tipo descritivo, observacional de caráter transversal realizado em Goiânia-Goiás, no período de agosto de 2013 a outubro de 2014, com grupo de pacientes cadastrados no Sistema de Monitoramento dos Radioacidentados (SISRAD) do Centro de Assistência aos Radioacidentados (C.A.R.A). Participaram da pesquisa 48 radioacidentados de um total de 102 que foram subdivididos em dois grupos: grupo 1 com 40 e o grupo 2 com 62 participantes. Realizou-se uma pesquisa de campo com questionário fechado e semi-estruturado em que foram abordados os seguintes contextos: perfil sociodemográfico, hábitos de vida e antecedentes pessoais. Criou-se um banco de dados utilizando-se o aplicativo Google Forms, da empresa de tecnologias na Web Google. Os dados devidamente coletados e armazenados foram importados e analisados no software estatístico SPSS, versão 21. Dos 48 entrevistados a prevalência de HAS atingiu um total 25% deles (12 indivíduos), sendo 50% de mulheres (24) e 50% de homens (24), dentre estes, 22,9% (11) dos radioacidentados revelaram ser tabagistas. A prevalência de HAS na população de radioacidentados se manifesta de forma semelhante ao da população em geral.

  11. VizieR Online Data Catalog: Circumnuclear star-forming regions (Alvarez-Alvarez+, 2015)

    NASA Astrophysics Data System (ADS)

    Alvarez-Alvarez, M.; Diaz, A. I.; Terlevich, E.; Terlevich, R.

    2016-01-01

    In order to achieve our scientific goals, we have studied a diverse population of galaxies with reported circumnuclear rings of SFRs in the bibliography. The data were acquired during five observing runs. For the first two runs (from 1988 to 1990), we used a blue sensitive GEC CCD at the f/15 Cassegrain focus of the 1.0m. Jacobus Kaptein Telescope of the Isaac Newton Group at the Observatorio del Roque de los Muchachos, La Palma, Spain. The CCD had 578x385 pixels 22um wide. The last three observing runs were carried on from 1999 to 2000 at the Centro Astronomico Hispano Aleman de Calar Alto, Almeria, Spain. (3 data files).

  12. Characterisation of gas and particle emissions from wildfires =

    NASA Astrophysics Data System (ADS)

    Vicente, Ana Margarida Proenca

    Os incendios florestais sao uma importante fonte de emissao de compostos gasosos e de aerossois. Em Portugal, onde a maioria dos incendios ocorre no norte e centro do pais, os incendios destroem todos os anos milhares de hectares, com importantes perdas em termos economicos, de vidas humanas e qualidade ambiental. As emissoes podem alterar consideravelmente a quimica da atmosfera, degradar a qualidade do ar e alterar o clima. Contudo, a informacao sobre as carateristicas das emissoes dos incendios florestais nos paises do Mediterrâneo e limitada. Tanto a nivel nacional como internacional, existe um interesse crescente na elaboracao de inventarios de emissoes e de regulamentos sobre as emissoes de carbono para a atmosfera. Do ponto de vista atmosferico da monitorizacao atmosferica, os incendios sao considerados um desafio, dada a sua variabilidade temporal e espacial, sendo de esperar um aumento da sua frequencia, dimensao e severidade, e tambem porque as estimativas de emissoes dependem das carateristicas dos biocombustiveis e da fase de combustao. O objetivo deste estudo foi quantificar e caraterizar as emissoes de gases e aerossois de alguns dos mais representativos incendios florestais que ocorreram no centro de Portugal nos veroes de 2009 e de 2010. Efetuou-se a colheita de amostras de gases e de duas fracoes de particulas (PM2.5 e PM2.5-10) nas plumas de fumo em sacos Tedlar e em filtros de quartzo acoplados a um amostrador de elevado volume, respetivamente. Os hidrocarbonetos totais (THC) e oxidos de carbono (CO e CO2) nas amostras gasosas foram analisados em instrumentos automaticos de ionizacao de chama e detetores nao dispersivos de infravermelhos, respetivamente. Para algumas amostras, foram tambem quantificados alguns compostos de carbonilo apos reamostragem do gas dos sacos Tedlar em cartuchos de silica gel revestidos com 2,4-dinitrofenilhidrazina (DNPH), seguida de analise por cromatografia liquida de alta resolucao. Nas particulas, analisou-se o carbono orgânico e elementar (tecnica termo-optica), ioes soluveis em agua (cromatografia ionica) e elementos (espectrometria de massa com plasma acoplado por inducao ou analise instrumental por ativacao com neutroes). A especiacao orgânica foi obtida por cromatografia gasosa acoplada a espectrometria de massa apos extracao com recurso a varios solventes e separacao dos extratos orgânicos em diversas classes de diferentes polaridades atraves do fracionamento com silica gel. Tendo em conta que a estimativa das emissoes dos incendios florestais requer um conhecimento de fatores de emissao apropriados para cada biocombustivel, a base de dados abrangente obtida neste estudo e potencialmente util para atualizar os inventarios de emissoes. Tem vindo a ser observado que a fase de combustao latente sem chama, a qual pode ocorrer simultaneamente com a fase de chama e durar varias horas ou dias, pode contribuir para uma quantidade consideravel de poluentes atmosfericos, pelo que os fatores de emissao correspondentes devem ser considerados no calculo das emissoes globais de incendios florestais. Devido a falta de informacao detalhada sobre perfis quimicos de emissao, a base de dados obtida neste estudo pode tambem ser util para a aplicacao de modelos no recetor no sul da Europa. (Abstract shortened by ProQuest.).

  13. North America - The Energy Picture II

    DTIC Science & Technology

    2006-01-01

    Desarrollo Urbano), of the National Urban System ( Sistema Urbano Nacional), and of the specific urban North America – The Energy Picture II...and guide for participants in international electricity trade. In January 2005, the Group released a companion to the 2002 electricity report, the

  14. Survey infravermelho do braço espiral de scuttum e da barra no centro galáctico

    NASA Astrophysics Data System (ADS)

    Amôres, E. B.; Lépine, J. R. D.

    2003-08-01

    O survey infravermelho consiste de observações utilizando a CAMIV no telescópio de 60 cm do LNA. Nosso principal objetivo é melhor caracterizar a população estelar dos braços espirais e de uma estrutura existente no centro galáctico que acreditamos ser devido à existência de uma barra, cujas extremidades estariam localizadas em longitudes galácticas l~23° e l~14°. As observações realizadas em vários filtros (imagens J, H e K) são particularmente importantes nas direções que tangenciam os braços espirais, desta forma, comparamos uma direção que atravessa um braço a uma direção próxima que não passa pelo braço, sendo que ambas possuem a mesma contribuição de contagens foreground. Nas missões realizadas até o presente, observamos a região na direção tangencial ao braço de Scuttum, com observações de l = 30.04° até l = 31.04°, a cada intervalo de longitude de 0.1°, para latitude galáctica de 0.0°, 0.25°, 0.50°. Para as regiões que acreditamos serem as extremidades da barra, observamos as faixas de longitude compreendidas entre -15° £ l £ -13° e 24° £ l £ 22° a cada intervalo de 0.25°, para latitude galáctica de 0.0° e 0.25°. As observações nos filtros J e H foram feitas com tempo de integração de 60s, na banda K, as observações foram feitas utilizando o filtro C1 com tempo de integração de aproximadamente 210 s (12x15s). Elaboramos diagramas cor-cor e cor-magnitude onde podemos verificar a existência de regiões com diferentes contagens e população estelar à medida que um braço espiral é atravessado.

  15. Mentorship: A Model of Nursing

    DTIC Science & Technology

    1991-01-01

    model was role specific modeling/ teaching. The mentor’s functions were to assist the protege in writing the grant proposal, in planning and conducting...producing role expectations ( Urbano , 1986). Called the creeping, crawling phase (Gunderson and Kenner, 1988), the protege tries to adjust to a new...form with Mentor 39 colleagues ( Urbano , 1986). Called sitting, standing phase, the nurse develops fine motor skills necessary to connect knowledge with

  16. Scavenger Receptors and Resistance to Inhaled Allergens

    DTIC Science & Technology

    2010-02-01

    throughput manner which will enable future studies. We plan to continue two especially interesting aspects of these studies. First, the epigenetic control...directs mod- ified proteins to antigen presentation. Eur. J. Immunol. 29: 512–521. 30. Granucci, F., F. Petralia, M. Urbano , S. Citterio, F. Di Tota, L...11 Suppl:S32-6. 50. Granucci F, Petralia F, Urbano M, Citterio S, Di Tota F, Santambrogio L, Ricciardi-Castagnoli P: The scavenger receptor MARCO

  17. Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe

    PubMed Central

    Fernandes, Por Luís

    2011-01-01

    Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

  18. Brazilian guidelines for the diagnosis and treatment of cystic fibrosis.

    PubMed

    Athanazio, Rodrigo Abensur; Silva Filho, Luiz Vicente Ribeiro Ferreira da; Vergara, Alberto Andrade; Ribeiro, Antônio Fernando; Riedi, Carlos Antônio; Procianoy, Elenara da Fonseca Andrade; Adde, Fabíola Villac; Reis, Francisco José Caldeira; Ribeiro, José Dirceu; Torres, Lídia Alice; Fuccio, Marcelo Bicalho de; Epifanio, Matias; Firmida, Mônica de Cássia; Damaceno, Neiva; Ludwig-Neto, Norberto; Maróstica, Paulo José Cauduro; Rached, Samia Zahi; Melo, Suzana Fonseca de Oliveira

    2017-01-01

    Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening program for CF has broad coverage, and most of the Brazilian states have referral centers for the follow-up of individuals with the disease. Previously, CF was limited to the pediatric age group. However, an increase in the number of adult CF patients has been observed, because of the greater number of individuals being diagnosed with atypical forms (with milder phenotypic expression) and because of the increase in life expectancy provided by the new treatments. However, there is still great heterogeneity among the different regions of Brazil in terms of the access of CF patients to diagnostic and therapeutic methods. The objective of these guidelines was to aggregate the main scientific evidence to guide the management of these patients. A group of 18 CF specialists devised 82 relevant clinical questions, divided into five categories: characteristics of a referral center; diagnosis; treatment of respiratory disease; gastrointestinal and nutritional treatment; and other aspects. Various professionals working in the area of CF in Brazil were invited to answer the questions devised by the coordinators. We used the PubMed database to search the available literature based on keywords, in order to find the best answers to these questions. RESUMO A fibrose cística (FC) é uma doença genética autossômica recessiva caracterizada pela disfunção do gene CFTR. Trata-se de uma doença multissistêmica que ocorre mais frequentemente em populações descendentes de caucasianos. Nas últimas décadas, diversos avanços no diagnóstico e tratamento da FC mudaram drasticamente o cenário dessa doença, com aumento expressivo da sobrevida e qualidade de vida. Atualmente, o Brasil dispõe de um programa de ampla cobertura para a triagem neonatal de FC e centros de referência distribuídos na maior parte desses estados para seguimento dos indivíduos. Antigamente confinada à faixa etária pediátrica, tem-se observado um aumento de pacientes adultos com FC tanto pelo maior número de diagnósticos de formas atípicas, de expressão fenotípica mais leve, assim como pelo aumento da expectativa de vida com os novos tratamentos. Entretanto, ainda se observa uma grande heterogeneidade no acesso aos métodos diagnósticos e terapêuticos para FC entre as diferentes regiões brasileiras. O objetivo dessas diretrizes foi reunir as principais evidências científicas que norteiam o manejo desses pacientes. Um grupo de 18 especialistas em FC elaborou 82 perguntas clínicas relevantes que foram divididas em cinco categorias: características de um centro de referência; diagnóstico; tratamento da doença respiratória; tratamento gastrointestinal e nutricional; e outros aspectos. Diversos profissionais brasileiros atuantes na área da FC foram convidados a responder as perguntas formuladas pelos coordenadores. A literatura disponível foi pesquisada na base de dados PubMed com palavras-chave, buscando-se as melhores respostas às perguntas dos autores.

  19. [Four stages in the history of the Centro Médico Nacional Siglo XXI of the IMSS].

    PubMed

    Fajardo-Ortiz, Guillermo

    2015-01-01

    This document presents four stages in the history of the Centro Médico Nacional Siglo XXI (Centro Médico Nacional XXI Century) of the Instituto Mexicano del Seguro Social. The first stage started at the end of the third decade of the twentieth century and ended in 1961, it corresponded to the conception, planning and construction of what was to be the Centro Médico del Distrito Federal (Centro Médico of the Distrito Federal) belonging to the Secretaría de Salubridad y Asistencia (Ministry of Health and Assistance). The second stage began when the Center was acquired by the Institute, then was known like Centro Médico Nacional (Centro Médico Nacional ), being put into full operation in 1963, more than twenty-two years later, in 1985, an earthquake virtually ended it, immediately began its reconstruction, finishing the second stage. In 1989 began the third stage, different and new buildings complemented or replaced the structures damaged or destroyed by the earthquake which formed the now Centro Médico Nacional Siglo XXI (Centro Médico Nacional XXI Century). In 2004 the fourth stage opened when the four hospitals of the Center were categorized like Unidades Médicas de Alta Especialidad (High Specialized Medical Units).

  20. Newborns' temperature submitted to radiant heat and to the Top Maternal device at birth.

    PubMed

    Albuquerque, Rosemeire Sartori de; Mariani, Corintio; Bersusa, Ana Aparecida Sanches; Dias, Vanessa Macedo; Silva, Maria Izabel Mota da

    2016-08-08

    to compare the axillar temperatures of newborns that are put immediately after birth in skin-to-skin contact under the Top Maternal device, as compared to those in a radiant heat crib. comparatives observational study of the case-control type about temperature of 60 babies born at the Obstetric Center and Normal Delivery Center of a public hospital of the municipality of Sao Paulo, being them: 29 receiving assistance in heated crib and 31 in skin-to skin contact, shielded by a cotton tissue placed on mother's thorax, called Top Maternal. the temperature of the babies of the skin-to-skin contact group presented higher values in a larger share of the time measures verified, as compared to those that were placed in radiant heat crib, independently from the place of birth. Differences between the two groups were not statistically significant. the study contributes to generate new knowledge, supporting the idea of keeping babies with their mothers immediately after birth protected with the Maternal Top, without harming their wellbeing, as it keeps the axillar temperature in recommendable levels. comparar a temperatura axilar dos recém-nascidos acomodados - imediatamente após o nascimento - em contato pele a pele, sob o Top Maternal, em berço de calor radiante. estudo comparativo observacional do tipo Caso-Controle sobre a temperatura de 60 bebês nascidos no Centro Obstétrico e Centro de Parto Normal de um hospital público do município de São Paulo, sendo: 29 assistidos em berço aquecido e 31 em contato pele a pele, protegidos por uma malha de algodão colocada sobre o tórax da mãe, denominada Top Maternal. a temperatura dos bebês do grupo de contato pele a pele teve maior valor na maioria dos tempos verificados comparada à dos que foram colocados em berço de calor radiante, independentemente do local de nascimento. A diferença entre os grupos não foi estatisticamente significante. o estudo contribui com a geração de um novo conhecimento que sustenta a manutenção dos bebês com suas mães imediatamente após o nascimento por meio do contato pele a pele protegidos pelo Top Maternal, sem prejuízos ao seu bem-estar, uma vez que a temperatura axilar se manteve em níveis recomendáveis. comparar la temperatura axilar de los recién nacidos (Rn) acomodados, inmediatamente después del nacimiento, en contacto piel con piel, bajo el Top Maternal, en cuna de calor radiante. estudio comparativo observacional del tipo Caso Control sobre la temperatura de 60 bebés nacidos en el Centro Obstétrico y Centro de Parto Normal de un hospital público del municipio de Sao Paulo, siendo: 29 asistidos en cuna calentada y 31 en contacto piel con piel, protegidos por un tejido de algodón colocado sobre el tórax de la madre, denominado Top Maternal. la temperatura de los bebés del grupo de contacto piel con piel fue más alta en la mayoría de los tiempos verificados, ello comparado con los que fueron colocados en cuna de calor radiante, independientemente del local de nacimiento. La diferencia entre los grupos no fue estadísticamente significativa. el estudio contribuye con la generación de un nuevo conocimiento que sustenta que se debe mantener a los bebés con sus madres inmediatamente después del nacimiento por medio del contacto piel con piel protegidos por el Top Maternal, sin perjuicios a su bienestar, una vez que la temperatura axilar se mantuvo en niveles recomendables.

  1. 75 FR 17561 - Amendment to Restricted Area R-2510A; El Centro, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ...-0346; Airspace Docket No. 10-AWP-3] RIN 2120-AA66 Amendment to Restricted Area R-2510A; El Centro, CA... Restricted Area R-2510A, El Centro, CA. Specifically, the action inadvertently omitted the reference to.... 92-AWP-15 entitled ``Alteration and Subdivision of Restricted Area R-2510A; El Centro, CA''. That...

  2. STRATEGIES IN SEARCH FOR INTERNATIONAL PARTNERSHIPS.

    PubMed

    Freitas, Denise de

    2015-01-01

    Internationalization is the process which integrates universal, intercultural or global dimension in a program, in this case, postgraduate. It can be understood as the process of increasing participation in international operations. To offer design and motivational logistics on how to run a process of international scientific relationship. It is necessary to develop several different aspects to be reached internationalization: to know the fundamentals of internationalization; to have international vision; to promote strategy for internationalization; to know the characteristics of an institutional center of internationalization; and to understand the institutional advantages of internationalization. Internationalization is essential to aerate the Brazilian postgraduate and not mischaracterize or weakens the process. On the contrary, it contributes to increase its vitality and capacity for innovation. Today is not possible to imagine science without internationalization. A internacionalização é o processo no qual se integra dimensão universal, intercultural ou global em um programa, no caso, de pós-graduação. Ela pode ser compreendida como o processo de participação crescente em operações internacionais. Apresentar concepção logística e motivacional de como executar um processo de relações científicas internacionais. É necessário o desenvolvimento de vários e diferentes aspectos para ser alcançada a internacionalização: conhecer os grandes eixos da internacionalização; ter visão internacional; promover estratégia para a internacionalização; saber das características de um centro institucional de internacionalização; e conhecer as vantagens institucionais da internacionalização. A internacionalização é imprescindível para arejar a pós-graduação brasileira e não a descaracteriza, menospreza ou enfraquece. Ao contrário, contribui para aumentar sua vitalidade e capacidade de inovação. Na atualidade não dá para imaginar a ciência sem internacionalização.

  3. A distribuição de velocidades na linha de visada em galáxias barradas vistas de face

    NASA Astrophysics Data System (ADS)

    Gadotti, D. A.; de Souza, R. E.

    2003-08-01

    Com o objetivo de realizar um estudo cinemático da componente vertical de barras em galáxias, obtivemos espectros de fenda longa de alta razão S/N ao longo dos eixos maior e menor de 14 galáxias barradas vistas de face, nos telescópios de 1.52m do ESO em La Silla, Chile, e de 2.3m do Steward Observatory em Kitt Peak, Arizona. Estes dados nos permitiram determinar a distribuição de velocidades das estrelas ao longo do eixo vertical das barras e discos destes sistemas, tanto no centro como em pontos que distam cerca de 5 e 20 segundos de arco do núcleo, correspondendo a distâncias de cerca de 0.7 e 2.8 kpc, respectivamente. Desta forma, a variação radial da distribuição de velocidades também pôde ser avaliada. Este tipo de análise tem raros exemplos na literatura por ser caro em termos de tempo de telescópio. Entretanto, é de fácil justificativa, considerando que traz novas informações que podem ser utilizadas para aperfeiçoar modelos teóricos acerca da formação e evolução de galáxias. Um algoritmo por nós desenvolvido foi utilizado para obter as distribuições de velocidades como Gaussianas generalizadas (polinômios de Gauss-Hermite), o que traz um ingrediente a mais neste tipo de estudo que, tradicionalmente, se utiliza de Gaussianas puras, uma hipótese nem sempre razoável. Apresentaremos os resultados deste trabalho, que incluem um diagnóstico para a identificação de barras recém formadas, e testes para o modelo isotérmico de discos. Mostraremos que: (i) a escolha das estrelas padrão em velocidade, e dos parâmetros da Gaussiana, deve ser muito bem justificada já que tem influência significativa nos resultados; (ii) muitas galáxias apresentam uma depressão na dispersão de velocidades na região central, que pode estar associada a um disco interno; e (iii) a dispersão de velocidades é constante ao longo da barra, nos eixos maior e menor, mas cai substancialmente quando se passa da barra para o disco.

  4. PREFACE: International Symposium on Ultrasound in the Control of Industrial Processes (UCIP 2012)

    NASA Astrophysics Data System (ADS)

    Segura, Luis Elvira; Resa López, Pablo; Salazar, Jordi; Benedito Fort, José Javier; Martínez Graullera, Óscar

    2012-12-01

    The following describes most of the presentations (both oral and poster) given at the International Symposium of Ultrasound in the Control of Industrial Processes (UCIP 2012) celebrated in Madrid between 18 and 20 April 2012. This event was intended to be a meeting point for scientists, engineers and professionals from all over the world in the field of ultrasonics applied to the characterization and control of materials and processes in the industry. More precisely, the topics included were: 1. Novel applications of ultrasound in the industry (including high-power ultrasound) Food science Biotechnology and microbiology Pharmaceutics and cosmetics Petrochemistry and civil engineering 2. New insights in the ultrasonic characterization of media: Fluids and emulsions Nano- and micro-particle dispersions Soft materials Porous bodies and inhomogeneous materials 3. New developments in ultrasonic measuring techniques: Acoustic microscopy Piezoelectric sensors Ultrasonic imaging Signal processing The symposium was organized by the Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND, UPM-CSIC) in collaboration with the Universidad Politécnica de Cataluña, the Universidad Politécnica de Valencia and the University of Leeds. During the conference, 32 posters and 33 oral communications were presented. In addition, 4 invited lectures were imparted: 'Acoustic microscopy, spectroscopy and nanoparticle detection' by Dr Malcolm Povey; 'Acoustic and electroacoustic spectroscopy' by Dr Andrei Dukhin; 'High-Resolution Ultrasonic Spectroscopy and its application for material analysis by Dr Vitaly Buckin; 'Ultrasonic sensors for process applications - state of the art' by Dr Bern Henning; and three tutorials were given: 'PZFlex - Finite Element Analysis for Virtual Prototyping' by Weidlinger Associates; 'SITAU - A flexible architecture controlled by MATLAB for the development of ultrasonic applications' by DASEL; 'Ultra-SCATTERERTM (Acoustics Suite) - The R&D Tool for Multiple Scattering of Generic Waves in Particulate Composites' by Félix Alba Consulting. A total of 93 delegates from 21 countries participated actively in this event, and more than ten companies were involved through oral communications, tutorials, exhibition or sponsorship. Conference photograph Conference photograph Organizers Organizers SCIENTIFIC COMMITTEE Dr Luis Elvira, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Pablo Resa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Oscar F Martinez-Graullera Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Jordi Salazar Department of Electronic Engineering Universitat Politècnica de Catalunya, Spain Dr Jose Benedito Universitat Politècnica de València, Spain ORGANIZING COMMITTEE Dr Luis Elvira, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Prof Malcolm J W Povey, Procter Department of Food Science University of Leeds, United Kingdom Dr Jordi Salazar, Department of Electronic Engineering Universitat Politècnica de Catalunya, Spain Dr Jose Benedito, Universitat Politècnica de València, Spain Dr Oscar F Martinez-Graullera, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Carmen Duran, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Pablo Resa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dra Cristina Aparicio, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Prof Francisco Montero de Espinosa, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Jaime Rodríguez-López, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Carlos Sierra, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Shiva Kant Shukla, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Pedro Castro Blazquez, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain David Romero Laorden, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Javier Rodrigo Villazón Terrazas, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Patricia Nevado, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Sofia Aparicio, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Montserrat Parrilla Romero, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Luis Gómez-Ullate Alvear, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Dr Alberto Ibáñez Rodríguez, Centro de Acústica Aplicada y Evaluación No Destructiva (CAEND), UPM-CSIC, Spain Sponsors Sponsors

  5. La contribución de los Centros Colaboradores de la OMS/OPS en los avances de la promoción de la salud en América Latina.

    PubMed

    Arroyo, Hiram V; Mantilla Uribe, Blanca P; Contreras Rengifo, Adolfo; Westphal, Marcia F; Mendes, Rosilda

    2016-09-01

    Los "Centros Colaboradores" de la Organización Mundial de la Salud (OMS) son instituciones designadas para prestar apoyo estratégico en el desarrollo de los objetivos y la ejecución de las actividades de la OMS, y para generar capacidad institucional en países y regiones. En las Américas existen ocho Centros Colaboradores directamente relacionados a la promoción de la salud. Cuatro centros se ubican en Norteamérica y los otros cuatro en América Latina. El propósito de este artículo es describir los Centros Colaboradores de la Región de América Latina. Los centros han sido importantes en el desarrollo de la agenda de promoción de la salud de la región, la consolidación de la estrategia de entornos saludables y el fortalecimiento de las redes académicas y profesionales de promoción de la salud. © The Author(s) 2015.

  6. Narrative Report of the El Centro de la Causa Library Project, 1973-1975.

    ERIC Educational Resources Information Center

    Chicago Public Library, IL.

    El Centro de la Causa and the Chicago Public Library cooperated in a program to serve Chicago's Spanish speaking population. The project assessed needs and designed programs to meet those needs by establishing a library in El Centro's community center and some outreach programs. An active acquisitions program for Spanish language materials was…

  7. Perfil dos Professores de Ciências Naturais do Recôncavo da Bahia - Alunos da Disciplina Terra e Universo no Curso de Ciências Naturais do Parfor

    NASA Astrophysics Data System (ADS)

    Lima, S. R.; Cerqueira Júnior, W.; Dutra, G.

    2011-12-01

    Este trabalho foi desenvolvido pelo projeto Astronomia no Recôncavo da Bahia, no Centro de Formação de Professores da Universidade Federal do Recôncavo da Bahia. Traçamos o perfil de um grupo de professores que lecionam conteúdos de Ciências Naturais no recôncavo, alunos do curso de Licenciatura em Ciências Naturais, oferecido dentro do Plano Nacional de Formação de Professores da Educação Básica. Nosso objetivo era avaliar se eles estão preparados para trabalhar conteúdos de Astronomia e identificar suas dificuldades. Os resultados serviram para orientar o professor da disciplina “Terra e Universo”, oferecida no segundo semestre de 2010. Durante a primeira aula da disciplina Terra e Universo, os alunos responderam a um questionário contendo questões abertas e fechadas, divididas em duas partes. A primeira procurando caracterizar profissionalmente os alunos enquanto professores da rede pública da região do Recôncavo Sul da Bahia e uma segunda parte procurando identificar conhecimentos básicos em Astronomia. Os resultados indicam uma predominância de professores do sexo feminino, com idade superior aos 40 anos, pardos e sem formação específica para o ensino de ciências. A maioria leciona há mais de 15 anos para turmas do 1º ao 5º ano, alguns lecionam para turmas de 6º ao 9º ano. Quase todos nunca participaram de um curso de formação continuada em Astronomia. Além disso, não estão habituados a ler revistas especializadas e nem livros com esta temática. Os que procuram ensinar temas voltados para a Astronomia têm, no livro didático, a maior fonte de informação sobre o assunto. As respostas também indicam uma deficiência em conteúdos básicos como a compreensão da esfericidade da Terra, noções de verticalidade e gravidade, incapacidade de identificar a Terra como um planeta, no Sistema Solar, em uma galáxia, no Universo. Estes resultados ressaltam a importância de disciplinas de Astronomia básica na formação dos professores da região.

  8. Centro-Apical Self-Organization of Organic Semiconductors in a Line-Printed Organic Semiconductor: Polymer Blend for One-Step Printing Fabrication of Organic Field-Effect Transistors

    PubMed Central

    Jin Lee, Su; Kim, Yong-Jae; Young Yeo, So; Lee, Eunji; Sun Lim, Ho; Kim, Min; Song, Yong-Won; Cho, Jinhan; Ah Lim, Jung

    2015-01-01

    Here we report the first demonstration for centro-apical self-organization of organic semiconductors in a line-printed organic semiconductor: polymer blend. Key feature of this work is that organic semiconductor molecules were vertically segregated on top of the polymer phase and simultaneously crystallized at the center of the printed line pattern after solvent evaporation without an additive process. The thickness and width of the centro-apically segregated organic semiconductor crystalline stripe in the printed blend pattern were controlled by varying the relative content of the organic semiconductors, printing speed, and solution concentrations. The centro-apical self-organization of organic semiconductor molecules in a printed polymer blend may be attributed to the combination of an energetically favorable vertical phase-separation and hydrodynamic fluids inside the droplet during solvent evaporation. Finally, a centro-apically phase-separated bilayer structure of organic semiconductor: polymer blend was successfully demonstrated as a facile method to form the semiconductor and dielectric layer for OFETs in one- step. PMID:26359068

  9. Centro-Apical Self-Organization of Organic Semiconductors in a Line-Printed Organic Semiconductor: Polymer Blend for One-Step Printing Fabrication of Organic Field-Effect Transistors.

    PubMed

    Lee, Su Jin; Kim, Yong-Jae; Yeo, So Young; Lee, Eunji; Lim, Ho Sun; Kim, Min; Song, Yong-Won; Cho, Jinhan; Lim, Jung Ah

    2015-09-11

    Here we report the first demonstration for centro-apical self-organization of organic semiconductors in a line-printed organic semiconductor: polymer blend. Key feature of this work is that organic semiconductor molecules were vertically segregated on top of the polymer phase and simultaneously crystallized at the center of the printed line pattern after solvent evaporation without an additive process. The thickness and width of the centro-apically segregated organic semiconductor crystalline stripe in the printed blend pattern were controlled by varying the relative content of the organic semiconductors, printing speed, and solution concentrations. The centro-apical self-organization of organic semiconductor molecules in a printed polymer blend may be attributed to the combination of an energetically favorable vertical phase-separation and hydrodynamic fluids inside the droplet during solvent evaporation. Finally, a centro-apically phase-separated bilayer structure of organic semiconductor: polymer blend was successfully demonstrated as a facile method to form the semiconductor and dielectric layer for OFETs in one- step.

  10. Solar Physics Topics in High School: Analysis of a Course with Practical Activities at Dietrich Schiel Observatory. (Spanish Title: Temas de Física Solar Para Estudiantes de Escuelas Secundarias: un Análisis de un Curso con Enfoque Práctico en el Observatorio Dietrich Schiel.) Tópicos de Física Solar no Ensino Médio: Análise de um Curso com Atividades Práticas no Observatório Dietrich Schiel

    NASA Astrophysics Data System (ADS)

    Calbo Aroca, Silvia; Donizete Colombo, Pedro, Jr.; Celestino Silva, Cibelle

    2012-12-01

    This work analyses results obtained in a solar physics course for high school students promoted at the Dietrich Schiel Observatory of the University of São Paulo (USP). The course was elaborated by the authors with the intention of investigating student's concepts about the Sun, teaching topics of modern physics related to the Sun and providing students with knowledge about our star as well. The methodology of data gathering consisted of audio and video records of classes and of semi-structured interviews, and analysis of answers to written questionnaires. The results showed that most high school students conceived the Sun as made of fire, while sunspots were thought to be holes in the Sun. Even though some students did know that a spectrum is formed using a prism or diffraction grating, most of them ignored the nature of the observed spectral lines. Through the course, this topic was developed by means of a practical approach with solar and lamp spectra observations. The results obtained in the course point to the importance of science centers as partners in formal education. In this specific case, the Solar Room at the Dietrich Schiel Observatory is as a favorable environment for teaching modern physics in high school. Este artículo analiza los resultados obtenidos en un curso sobre la física solar, auspiciado por el Observatorio Dietrich Schiel de la USP para estudiantes de las escuelas secundarias. El curso fue diseñado por los autores con la intención de investigar las concepciones sobre el sol, enseñar temas relacionados con la física moderna del Sol y conocimientos generales sobre el astro rey. La metodología utilizada para la recolección de datos consistió en grabar, en audio y video, las clases, las entrevistas semi-estructuradas y las respuestas a los cuestionarios escritos. Los resultados mostraron que la mayoría de los participantes conciben el Sol como constituido por fuego y las manchas solares en la superficie solar como agujeros. Aunque algunos estudiantes sabían que un espectro puede estar formado por un prisma o red de difracción, la mayor parte de ellos desconocía la naturaleza de las líneas espectrales. A lo largo del curso, esta cuestión fue trabajada con un enfoque práctico mediante la observación del espectro solar y de las lámparas durante clases expositivas/dialogadas. Los resultados obtenidos en el curso mustran la importancia de los centros de ciencia como un apoyo en la educación formal. En este caso en particular, la Sala Solar del Observatorio Dietrich Schiel se destaca como un entorno favorable para la enseñanza de la física moderna en la escuela secundaria. Este trabalho analisa resultados obtidos em um curso sobre física solar para alunos do ensino médio promovido pelo Observatório Dietrich Schiel da USP. O curso foi elaborado pelos autores com a intenção de investigar concepções sobre o Sol, ensinar tópicos de física moderna relacionados ao Sol e conhecimentos gerais sobre o astro rei. A metodologia de coleta de dados consistiu em gravação em áudio e vídeo das aulas e das entrevistas semi-estruturadas, e respostas a questionários escritos. Os resultados mostraram que a maioria dos participantes concebeu o Sol como constituído por fogo e as manchas solares como buracos na superfície solar. Embora alguns alunos soubessem que um espectro pode ser formado por um prisma ou rede de difração, a maior parte deles desconhecia a natureza das linhas espectrais. Ao longo do curso, este tema foi trabalhado com uma abordagem prática com observação do espectro solar e de lâmpadas e em aulas expositivo-dialogadas. Os resultados obtidos no curso apontam para a importância dos centros de ciências como parceiros da educação formal. Neste caso específico, a Sala Solar do Observatório Dietrich Schiel é um ambiente propício para o ensino de física moderna no ensino médio.

  11. Anticipation of somatosensory and motor events increases centro-parietal functional coupling: an EEG coherence study.

    PubMed

    Babiloni, Claudio; Brancucci, Alfredo; Vecchio, Fabrizio; Arendt-Nielsen, Lars; Chen, Andrew C N; Rossini, Paolo M

    2006-05-01

    Does functional coupling of centro-parietal EEG rhythms selectively increase during the anticipation of sensorimotor events composed by somatosensory stimulation and visuomotor task? EEG data were recorded in (1) 'simultaneous' condition in which the subjects waited for somatosensory stimulation at left hand concomitant with a Go (or NoGo) visual stimulus triggering (50%) right hand movements and in (2) 'sequential' condition where the somatosensory stimulation was followed (+1.5 s) by a visuomotor Go/NoGo task. Centro-parietal functional coupling was modeled by spectral coherence. Spectral coherence was computed from Laplacian-transformed EEG data at delta-theta (2-7 Hz), alpha (8-14 Hz), beta 1 (15-21 Hz), beta 2 (22-33 Hz), and gamma (34-45 Hz) rhythms. Before 'simultaneous' sensorimotor events, centro-parietal coherence regions increased in both hemispheres and at all rhythms. In the 'sequential' condition, right centro-parietal coherence increased before somatosensory event (left hand), whereas left centro-parietal coherence increased before subsequent Go/NoGo event (right hand). Anticipation of somatosensory and visuomotor events enhances contralateral centro-parietal coupling of slow and fast EEG rhythms. Predictable somatosensory and visuomotor events are anticipated not only by synchronization of cortical pyramidal neurons generating EEG power in parietal and primary sensorimotor cortical areas (Babiloni C, Brancucci A, Capotosto P, Arendt-Nielsen L, Chen ACN, Rossini PM. Expectancy of pain is influenced by motor preparation: a high-resolution EEG study of cortical alpha rhythms. Behav. Neurosci. 2005a;119(2):503-511; Babiloni C, Brancucci A, Pizzella V, Romani G.L, Tecchio F, Torquati K, Zappasodi F, Arendt-Nielsen L, Chen ACN, Rossini PM. Contingent negative variation in the parasylvian cortex increases during expectancy of painful sensorimotor events: a magnetoencephalographic study. Behav. Neurosci. 2005b;119(2):491-502) but also by functional coordination of these areas.

  12. Differential Dengue Tropism & Neutralization: Potential Mechanisms of Pathogenesis

    DTIC Science & Technology

    2006-01-04

    Dr. Guillermo Comach and Dr. Daria Camacho, Laboratorio Regional de Diagnostico e Investigacion del Dengue y otras Enfermedades Virales, Centro de... Enfermedades Virales, Centro de Investigaciones Biomedicas de la Universidad de Carabobo (LARDIDEV/BIOMED- UC), Maracay, Venezuela. 4Naval Medical Research

  13. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg..., 43 Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8...

  14. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg..., 43 Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8...

  15. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg... Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8 Fresno 7, 30...

  16. 47 CFR 73.622 - Digital television table of allotments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44c Coalinga *22 Concord 63c Corona 39 Cotati *23c El Centro 22, 48 Eureka *11, 16, 17, 28 Fort Bragg... Clovis 43 Concord 14 Corona 39 Cotati *23 El Centro 9, 22 Eureka 3, *11, 17, 28 Fort Bragg 8 Fresno 7, 30...

  17. A Introdução de Astronomia Básica para Estudantes de 5 e 6 Séries do Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    Gonzaga, E. P.; Voelzke, M. R.

    2008-09-01

    Com intuito de despertar o interesse pelo estudo da astronomia, desenvolveu-se entre 2003 e 2006 no Centro Educacional do Serviço Social da Indústria situado no município de Mauá, São Paulo, um trabalho com duração de 12 meses para turmas de 11 e 12 anos, sendo três turmas por período (2003 / 2004, 2004 / 2005 e 2005 / 2006). O trabalho realizado, objetivando a introdução da astronomia básica com observações de constelações e das fases da Lua, permitindo estender-se a outros corpos celestes, iniciou-se com visita ao planetário Mundo Estelar, localizado no Ipiranga, São Paulo levantou-se a questão da importância do estudo da astronomia e foi lançado aos estudantes um trabalho de observação, com a proposta de localizar as constelações e compreender as fases da Lua, para o registro de tais observações, foram distribuídos mapas celestes, pastas, planilhas de anotações com lacunas para, constelações, fases da Lua e relatos, onde os estudantes acrescentaram pesquisas e relatórios. Os resultados dos 346 estudantes foram que 86,7% (300) concluíram a etapa de observação, destes 300 estudantes 43,3% (130) pesquisaram sobre as constelações e 19,0% (57) localizaram até quatro constelações. Dos 346 estudantes, 44,2% (153) registraram as fases da Lua equivocadamente e 10,4% (36) anexaram reportagens sobre astronomia. Conclui-se que os estudantes se dividiram em pesquisadores, sendo os estudantes que registraram e anexaram informações e, os observadores que preencheram as planilhas de observações, além de desenvolverem habilidades e competências relacionadas ao estudo da astronomia.

  18. Low-dose, Chronic Exposure to Silver Nanoparticles Causes Mild Mitochondrial Alterations in the Liver of Sprague-Dawley Rat

    DTIC Science & Technology

    2014-05-10

    of Sprague-Dawley rat CARLOS PALMEIRA CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR (CNC) DEPARTAMENTO DE ZOOLOGIA COIMBRA 3000 - 329...CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR (CNC) DEPARTAMENTO DE ZOOLOGIA COIMBRA 3000 - 329 PORTUGAL 8. PERFORMING ORGANIZATION REPORT NUMBER

  19. El Centro College Strategic Plan, 2000-2005.

    ERIC Educational Resources Information Center

    El Centro Coll., Dallas, TX.

    This is the 2000-2005 strategic plan at El Centro College (Texas). It discusses the college's mission, vision, and core values, and provides information on goals and success indicators. Goals include: (1) preparing students for careers and for transfer to four-year institutions; (2) providing quality continuing/workforce education to enrich…

  20. South Atlantic Conflict of 1982: A Case Study in Military Cohesion

    DTIC Science & Technology

    1988-04-01

    Level Technical School); Centro de Instruction de Inteligencia (Center for Intelligence Instruction) and Centro de Altos Estudios (The Center for...pero plenos de emocion y grandeza. (1987). La Semana, 12-15. Gal, R. (1985). Committment and obedience in the military: An Israeli case study. Armed

  1. Education

    DTIC Science & Technology

    2003-01-01

    Frank Sosa, Dept. of the Air Force Col Juan Urbano , Peruvian Army Dr. Francis A’Hearn, Faculty Prof. William Mayall, Faculty COL Mark McGuire...insufficient time to meet job requirements such as planning lessons to grading papers, to participating in mandatory training to phoning parents to...

  2. Mass transit : review of the Tren Urbano finance plan

    DOT National Transportation Integrated Search

    2000-03-31

    In summary, we found that the Authority has sufficient funding to meet the expected cost of the project without seeking additional New Starts funds or adversely affecting other parts of the transportation system in Puerto Rico. To finance the project...

  3. The Gran Telescopio Canarias and Calar Alto Virtual Observatory Compliant Archives

    NASA Astrophysics Data System (ADS)

    Alacid, J. M.; Solano, E.; Jiménez-Esteban, F. M.; Velasco, A.

    2014-05-01

    The Gran Telescopio Canarias and Calar Alto archives are the result of the collaboration agreements between the Centro de Astrobiología and two entities: GRANTECAN S.A. and the Centro Astronómico Hispano Alemán (CAHA). The archives have been developed in the framework of the Spanish Virtual Observatory and are maintained by the Data Archive Unit at Centro de Astrobiología. The archives contain both raw and science ready data and have been designed in compliance with the standards defined by the International Virtual Observatory Alliance, which guarantees a high level of data accessibility and handling. In this paper we describe the main characteristics and functionalities of both archives.

  4. Book of Abstracts (Plasma-Surface Interaction and Processing of Materials)

    DTIC Science & Technology

    1989-09-22

    Capuj* and M. N. Jakas** Centro Atomico Bariloche , C.N.E.A. 8400 Bariloche, Argentina Analytical calculations have been done in order to evaluate...CHARACTERIZATION BY ION BEAM TECHNIQUE N. E. Capuj*, N. R. Arista, G. H. Lantchsner, J. C. Eckardt, and M. M. Jakas** Centro Atomico Bariloche , C.N.E.A. 8400

  5. Centro TORTUGA's Integrated Research and Professional Development Training for Early Stage Hispanic Students in Puerto Rico

    NASA Astrophysics Data System (ADS)

    Moser, F. C.; Allen, M. R.; Barberena-Arias, M.; Clark, J.; Harris, L.; Maldonado, P. M.; Olivo-Delgado, C.; Pierson, J. J.

    2017-12-01

    Over the last five years our multidisciplinary team explored different undergraduate research and professional development (PD) strategies to improve early stage Hispanic student retention in marine science with the objective of interesting them in pursuing degrees that may ultimately lead to geoscience careers. This research led to the 2016 launch of our current project, Centro TORTUGA (Tropical Oceanography Research Training for Undergraduate Academics). Our overarching goal is to increase the number of underrepresented students from minority serving institutions in geoscience-relevant disciplines and careers. Critical to success is building a program rich in both research and PD. Based on qualitative and quantitative evaluations we found students benefited from PD efforts to increase skills in areas such as: 1) speaking and writing English; 2) science communication; 3) teamwork; 4) project management; and 5) completing internship/graduate school applications. To build student self-confidence, networking, and science skills Centro Tortuga involves students' families, bridges cultural gaps across research and non-research institutions inside and outside of Puerto Rico, and provides a gathering place (Centro TORTUGA) for students. With our partners, Universidad del Turabo (UT), Universidad Metropolitana (UMET), and University of Maryland Center for Environmental Sciences, we are now testing a 12-month integrated research and PD curriculum. Initial results suggest areas for improved student training include: 1) science communication (reports and graphs); 2) science ethics; and 3) poster and oral presentations. Students also identified specific preparation they would like included in the Centro TORTUGA curriculum.

  6. A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2006-08-01

    O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam a astronomia, como por exemplo a propagação do som no vácuo observado na maioria dos filmes de f icção científica ou da existência das estações do ano em função da distância da Terra ao Sol, em conformidade com o questionário aplicado.

  7. Defense Technical Information Center Cataloging Guidelines

    DTIC Science & Technology

    1994-02-01

    24 Field 10 - Personal Authors ............................................................ 27 Field 11 - Date of...Stanford, Calif. 24 . If the subordinate element of a heading begins with a personal name, that name is written without rearrangement. APPEARS AS...country is not repeated if ’ncluded in the heading. APPEARS AS: ENTER AS: Centro Brasileiro de Pesquisas Centro Brasileiro de Fisicas, Rio de Janeiro

  8. Indicators of Success in Achieving the El Centro College Goals, 1997-2000.

    ERIC Educational Resources Information Center

    El Centro Coll., Dallas, TX.

    This is a report on indicators of success in achieving community college goals at El Centro College (Texas). The report provides statistics from 1997-2000 and focuses on the progress of nine goals: (1) institutionalizing service beyond expectation--according to student satisfaction surveys, campus changes that have occurred between 1996 and 1999…

  9. 78 FR 13645 - Notice of Public Meetings for the Draft Environmental Impact Statement and Draft Clean Air Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... Conformity Determination in an open house format. DoN representatives will be available at informational... Determination are available for public review at the following libraries: 1. City of El Centro Public Library, 1140 North Imperial Avenue, El Centro, California 92243. 2. City of Imperial Public Library, 200 West...

  10. Proceedings of the 30th Annual Precise Time and Time Interval (PTTI) Systems and Applications Meeting

    DTIC Science & Technology

    1999-01-01

    roa.es C. Tomis RedIRIS, Centro Comunicaciones CSIC RedIRIS Serrano 142, 28006 Madrid, Spain tel + 34-91-585-5150 fax +34-91-564-7421 e-mail...I&D) and managed by the Centro de Comunicaciones CSIC RedIRIS, which depends on the Scientific Research Council (Consejo Superior de Investigaciones

  11. Long-Term Follow-Up of Patients after Percutaneous Coronary Intervention with Everolimus-Eluting Bioresorbable Vascular Scaffold.

    PubMed

    Meneguz-Moreno, Rafael Alexandre; Costa, José de Ribamar; Moscoso, Freddy Antônio Britto; Staico, Rodolfo; Tanajura, Luiz Fernando Leite; Centemero, Marinella Patrizia; Chaves, Auréa Jacob; Abizaid, Andrea Claudia Leão de Sousa; Sousa, Amanda Guerra de Moraes Rego E; Abizaid, Alexandre Antonio Cunha

    2017-02-01

    Bioresorbable vascular scaffolds (BVS) were developed to improve the long-term results of percutaneous coronary intervention, restoring vasomotion. To report very late follow-up of everolimus-eluting Absorb BVS (Abbott Vascular, Santa Clara, USA) in our center. Observational retrospective study, in a single Brazilian center, from August 2011 to October 2013, including 49 patients submitted to Absorb BVS implantation. Safety and efficacy outcomes were analyzed in the in-hospital and very late follow-up phases (> 2 years). All 49 patients underwent a minimum follow-up of 2.5 years and a maximum of 4.6 years. Mean age was 56.8 ± 7.6 years, 71.4% of the patients were men, and 26.5% were diabetic. Regarding clinical presentation, the majority (94%) had stable angina or silent ischemia. Device success was achieved in 100% of cases with 96% overall procedure success rate. Major adverse cardiovascular events rate was 4% at 30 days, 8.2% at 1 year, and 12.2% at 2 years, and there were no more events until 4.6 years. There were 2 cases of thrombosis (1 subacute and 1 late). In this preliminary analysis, Absorb BVS showed to be a safe and effective device in the very late follow-up. Establishing the efficacy and safety profiles of these devices in more complex scenarios is necessary. Os suportes vasculares bioabsorvíveis (SVB) foram desenvolvidos com o intuito de melhorar os resultados da intervenção coronária percutânea a longo prazo, restabelecendo-se a vasomotricidade. Reportar o seguimento muito tardio do implante do SVB eluidor de everolimus Absorb® (Abbot Vascular, Santa Clara, EUA) em nosso centro. Estudo observacional, retrospectivo, em um único centro brasileiro, que incluiu 49 pacientes submetidos ao implante do SVB Absorb® entre agosto/2011 e outubro/2013. Foram analisados os desfechos de segurança e eficácia na fase hospitalar e bastante tardia (> 2 anos). Todos os 49 pacientes completaram um seguimento mínimo de 2,5 anos, sendo o máximo de 4,6 anos. A média de idade foi 56,8 ± 7,6 anos, sendo 71,4% da população estudada do sexo masculino e 26,5% composta por diabéticos. Considerando a apresentação clínica, a grande maioria (94%) tinha angina estável ou isquemia silenciosa. Obteve-se sucesso do dispositivo em 100% dos casos e do procedimento, em 96%. A taxa de eventos cardiovasculares maiores foi de 4% aos 30 dias, de 8,2% em 1 ano, e de 12,2% em 2 anos, sem mais eventos até 4,6 anos. Houve 2 casos de trombose (1 subaguda e 1 tardia) até o último seguimento. Nesta análise preliminar, o uso do SVB Absorb® mostrou-se seguro e eficaz no seguimento bastante tardio. Faz-se necessário estabelecer o perfil de eficácia e segurança destes dispositivos em cenários de maior complexidade.

  12. Aluminum Alloys Reinforced by Nano-Particles Dispersion

    DTIC Science & Technology

    2010-03-01

    C. Mendoza Ruiz, R. Martinez-Sanchez. Propiedades mecdnicas de compositos aluminio- nanotubos de carbono . Primer Encuentro Internacional ICM 2007...UNIT NUMBER N/A 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Centro de Investigacion en Materiales Avanzados, S.C. Miguel de Cervantes # 120...Principal Investigator: Dr. Roberto Martinez Sanchez Institution: Centro de Investigation en Materiales Avanzados, S.C. Address: Miguel de Cervantes

  13. Rapid detection of trichodysplasia spinulosa-associated polyomavirus in skin biopsy specimen.

    PubMed

    Urbano, Paulo Roberto P; Pannuti, Cláudio Sérgio; Pierrotti, Ligia C; David-Neto, Elias; Romano, Camila Malta

    2014-07-24

    Trichodysplasia spinulosa-associated polyomavirus (TSV) is responsible for a rare skin cancer. Using metagenomic approaches, we determined the complete genome sequence of a TSV first detected in Brazil in spicules of an immunocompromised patient suspected to have trichodysplasia spinulosa. Copyright © 2014 Urbano et al.

  14. An Evaluation of the El Centro de la Causa Library and Information Center: August 1973 through July 1974. Final Report.

    ERIC Educational Resources Information Center

    Michael, Mary Ellen; Encarnacion, Leticia

    An evaluation of Chicago's El Centro de la Causa Library and Information Center was undertaken by the University of Illinois Library Research Center in 1974. Evaluation methods included: (1) a survey of user and nonuser characteristics and attitudes concerning library services; (2) a survey of the needs and information-seeking behavior of people…

  15. Wave Attenuation on Muddy Bottoms - A Multidisciplinary Field Study Offshore Cassino Beach, Southern Brazil

    DTIC Science & Technology

    2005-09-30

    Rio de Janeiro Ocean Engineering Program / COPPE CP 68508 - Centro de Tecnologia - C203 21945-970 Rio de Janeiro , Brazil Phone/fax...NAME(S) AND ADDRESS(ES) Federal University of Rio de Janeiro ,Ocean Engineering Program / COPPE, CP 68508 - Centro de Tecnologia - C203,21945-970 Rio ...activities of the project: From Brazilian Institutions: 1- Federal University of Rio de Janeiro (UFRJ) / Laboratory for

  16. Home | Departamento de Salud de Puerto Rico

    Science.gov Websites

    Publicaciones Registros Suicidio Tuberculosis Centro de Aprendizaje Virtual sobre temas de Preparación en Salud Tuberculosis Centro de Aprendizaje Virtual sobre temas de Preparación en Salud Pública Informe de Casos de Departamento de Salud Search... Search It looks like your browser does not have JavaScript enabled

  17. Research Program In Tropical Infectious Diseases

    DTIC Science & Technology

    1991-12-15

    Central America at the base of the Yucatan Peninsula, surrounded on the west and north by Guatemala and Mexico and on the east by the Caribbean Sea...inferred that in Belize, 2 tropical infectious diseases are common. Yellow fever has been known to occur in the Yucatan ,1 dengue and malaria are...Centro Americano) representatives in Belize City. Two ERC technologists and two CML technicians attended an INCAP (Instituto de Nutricion de Centro

  18. Family of older adults with mental disorder: perception of mental health professionals.

    PubMed

    Saidel, Maria Giovana Borges; Campos, Claudinei José Gomes

    2017-01-01

    to understand the perceptions of healthcare professionals of the Psychosocial Care Centers regarding the family of older adults with mental disorders. study of a Qualitative Case conducted with 12 healthcare professionals from a Psychosocial Care Center, with a convenient and exhaustive sample. Conducting semi-structured interviews to collect data, which were analyzed with the Content Analysis technique. the following categories stood out: "Family exhaustion and deterioration in the perception of the healthcare professional" and "The abandonment of older adults by family members and their distancing in the perception of the healthcare professional." culpability of older adults and penalization of the family were verified by healthcare professionals. To bring awareness about the difficulties faced in the attempt to bring the family closer to the healthcare service, it is necessary to analyze the care given to the older adult and to overcome challenges in the effective construction of the bond between family, healthcare user and mental health service. compreender as percepções dos profissionais do Centro de Atenção Psicossocial acerca da família do idoso em sofrimento psíquico. estudo de Caso Qualitativo conduzido com 12 profissionais de um Centro de Atenção Psicossocial com amostra composta por intencionalidade e fechada por exaustão. Realização de entrevistas semiestruturadas para coleta de dados, analisados por meio da técnica de Análise de Conteúdo. destacaram-se as categorias "O cansaço e o desgaste familiar na percepção do profissional" e "O abandono e o afastamento do idoso pela família na percepção do profissional". verificou-se a culpabilização do idoso e a penalização da família pelos profissionais. Visando à conscientização das dificuldades em aproximar a família, é necessária a criação de espaços reflexivos sobre o cuidado a essa população, bem como a superação dos desafios na construção efetiva do vínculo entre família, usuário e serviço de saúde mental.

  19. Potential intravenous drug interactions in intensive care.

    PubMed

    Moreira, Maiara Benevides; Mesquita, Maria Gefé da Rosa; Stipp, Marluci Andrade Conceição; Paes, Graciele Oroski

    2017-07-20

    To analyze potential intravenous drug interactions, and their level of severity associated with the administration of these drugs based on the prescriptions of an intensive care unit. Quantitative study, with aretrospective exploratory design, and descriptive statistical analysis of the ICU prescriptions of a teaching hospital from March to June 2014. The sample consisted of 319 prescriptions and subsamples of 50 prescriptions. The mean number of drugs per patient was 9.3 records, and a higher probability of drug interaction inherent to polypharmacy was evidenced. The study identified severe drug interactions, such as concomitant administration of Tramadol with selective serotonin reuptake inhibitor drugs (e.g., Metoclopramide and Fluconazole), increasing the risk of seizures due to their epileptogenic actions, as well as the simultaneous use of Ranitidine-Fentanyl®, which can lead to respiratory depression. A previous mapping of prescriptions enables the characterization of the drug therapy, contributing to prevent potential drug interactions and their clinical consequences. Analisar as potenciais interações medicamentosas intravenosas e seu grau de severidade associadas à administração desses medicamentos a partir das prescrições do Centro de Terapia Intensiva. Estudo quantitativo, tipologia retrospectiva exploratória, com análise estatística descritiva das prescrições medicamentosas do Centro de Terapia Intensiva de um Hospital Universitário, no período de março-junho/2014. A amostra foi composta de 319 prescrições e subamostras de 50 prescrições. Constatou-se que a média de medicamentos por paciente foi de 9,3 registros, e evidenciou-se maior probabilidade para ocorrência de interação medicamentosa inerente à polifarmácia. O estudo identificou interações medicamentosas graves, como a administração concomitante de Tramadol com medicamentos inibidores seletivos da recaptação da serotonina, (exemplo: Metoclopramida e Fluconazol), aumentando o risco de convulsões devido às suas ações epileptogênicas, além do uso simultâneo de Ranitidina-Fentanil®, que pode ocasionar depressão respiratória. O mapeamento prévio das prescrições possibilita a caracterização da terapêutica medicamentosa, contribuindo para obstar as potenciais interações medicamentosas e suas consequências clínicas.

  20. Analisis espacial de las areas protegidas terrestres de Puerto Rico

    Treesearch

    M. Quinones; W.A. Gould; J. Castro-Prieto; S. Martinuzzi

    2013-01-01

    En este mapa de investigacion describimos las areas protegidas terrestres de Puerto Rico basado en elementos naturales y antropogenicos del paisaje. Utilizamos datos geoespaciales para calcular la extension y representatividad de elementos del paisaje dentro de las areas protegidas de Puerto Rico, i.e., cobertura del terreno (Gould et al. 2007), asentamientos urbanos...

  1. Latin American Security Challenges: A Collaborative Inquiry from North and South

    DTIC Science & Technology

    2004-01-01

    Jorge Eduardo Malena, and Gabriela E. Porn Conclusion 103 Bibliography 109 Abbreviations 115 Contributors 117 Collaborating Organizations 119 Titles...Malena of the Catholic University, Bue- nos Aires; and Gabriela E. Porn of the Centro de Estudios Hemisféricos on their chapter. With good fortune and...Malena of the Catholic University, Buenos Aires; and Gabriela E. Porn of the Centro de Estudios Hemisféricos assess “Chinese Interests in Latin

  2. Translation, cultural adaptation and validation of Kidney Disease Loss Scale to the Brazilian context.

    PubMed

    Ottaviani, Ana Carolina; Orlandi, Fabiana de Souza

    2016-01-01

    Losses can be conceptualized as cognitive and affective responses to individual sorrows, characterized by brooding, yearning, disbelief and stunned feelings, being clinically significant in chronic diseases. The aim of the study was to translate, culturally adapt and validate the Kidney Disease Loss Scale into Portuguese. Validation study involving the steps recommended in the literature for healthcare instruments: initial translation, synthesis of translations, back translation, review by a committee of judges and pretest. The scale was translated and adapted to the Portuguese language, being quick and easy to application. The reliability and reproducibility showed satisfactory values. Factor analysis indicated a factor that explains 59.7% of the losses construct. The Kidney Disease Loss Scale was translated, adapted and validated for the Brazilian context, allowing future studies of losses and providing tools for the professionals working in dialysis centers for assistance to people with chronic kidney disease. As perdas podem ser conceituadas como respostas cognitivas e afetivas para tristezas individuais, caracterizadas pelo remoer, anseio, descrença e sentimentos atordoados, sendo clinicamente significativa em doenças crônicas. O objetivo do estudo foi traduzir, adaptar culturalmente e validar o Kidney Disease Loss Scale para a língua portuguesa. Estudo de validação envolveu as etapas preconizadas na literatura internacional para instrumentos da área de saúde: tradução inicial, síntese das traduções, retrotradução, revisão por um comitê de juízes, pré-teste e avaliação das propriedades psicométricas. A escala foi traduzida e adaptada para o idioma português, sendo de fácil e rápida aplicação. A confiabilidade e a reprodutibilidade apresentaram valores satisfatórios. A análise fatorial indicou um fator que explica 59,7% do constructo de perdas. A Escala de Perdas referente à Doença Renal foi traduzida, adaptada e validada para o contexto brasileiro, permitindo estudos futuros sobre perdas e instrumentalizando os profissionais atuantes em centros de diálise para assistência à pessoa com doença renal crônica.

  3. Forms of Appropriation of Tools for the Astronomy Education in Continuous Training of Teachers. (Spanish Title: Formas de Apropriación de Herramientas Para la Enseñanza de la Astronomía en la Formación Docente Continua.) Formas de Apropriação de Instrumentos Para o Ensino de Astronomia na Formação Continuada de Professores

    NASA Astrophysics Data System (ADS)

    Marques Soares, Leonardo; Sousa Nascimento, Silvania

    2012-07-01

    The main focus of this article is to present some impressions about the way some teachers appropriated of the tools from the ASTRONOMY TEACHING KIT (KITPEA). The subjects of this research were teachers that took part in the astronomy teaching specialization course offered by the Continuing Education Project (FOCO) at Math and Science Teaching Center (CECIMIG) from the School of Education of Federal University of Minas Gerais (FaE/UFMG). The data was collected with the use of a questionnaire and of an interview applied to these teachers. The analysis of the data was structured with the aid of the Activity Theory and the Mediated Action Theory. We interpret the teachers' speech using the constitutive aspects of the activity system and the concepts of appropriation and domain as an analytical device. It was possible to recognize the appropriation of the tools in 7 narratives among the 11 individuals who took part in the research. El objetivo principal de ese artículo es presentar indicaciones sobre la manera como algunos maestros se apropiaron de las herramientas del KIT PARA LA ENSEÑANZA DE LA ASTRONOMÍA (KITPEA). Los sujetos de esa investigación son docentes que participaron del curso de especialización en enseñanza de astronomía ofrecido por el Proyecto de Formación Continua (Foco) en el Centro de Enseñanza de Ciencias y Matemática (CECIMIG) de la Facultad de Educación de la Universidad Federal de Minas Gerais (FaE/UFMG). Recogimos las informaciones a través de un cuestionario y de una encuesta, aplicados a esos docentes. Estructuramos el análisis de esas informaciones con la ayuda de la Teoría de la Actividad y de la Teoría de la Acción Mediada. Interpretamos os discursos de los docentes usando como dispositivo analítico los elementos constitutivos del sistema de actividad y los conceptos apropiación y dominio. Entre los 11 sujetos que participaron de la investigación, fue posible interpretar con claridad la apropiación de las herramientas en siete relatos. O objetivo principal desse artigo é apresentar algumas reflexões sobre a maneira como um grupo de professores se apropriaram dos instrumentos do KIT PARA O ENSINO DE ASTRONOMIA (KITPEA). Os sujeitos dessa pesquisa participaram do curso de especialização em ensino de astronomia oferecido pelo Projeto de Formação Continuada (Foco) no Centro de Ensino de Ciências e Matemática (CECIMIG) da Faculdade de Educação da Universidade Federal de Minas Gerais (FaE/UFMG). Coletamos as informações por meio de um questionário e de uma entrevista, aplicados a esses professores. Estruturamos a análise dessas informações com a ajuda da Teoria da Atividade e da Teoria da Ação Mediada. Interpretamos as falas dos professores usando como dispositivo analítico os elementos constituintes do sistema de atividade e os conceitos de apropriação e domínio. Dentre os 11 sujeitos que participaram da pesquisa, foi possível identificar a apropriação dos instrumentos em 7 narrativas.

  4. Power Pack: U.S. Intervention in the Dominican Republic, 1965-1966 (Leavenworth Papers, Number 15)

    DTIC Science & Technology

    1988-07-01

    Center (Centro de Entrenamiento de las Fuerzas 22 Elias Wessin y Wessin Armadas, or CEFA), an elite group of nearly 2,000 specially trained infan- try...battalion combat team battalion landing team Centro de Entrenamiento de las Fuerzas Armadas (Armed Forces Training Cen- ter) Central Intelligence...operations. As with Lebanon in 1958, the Domin- ican intervention was a joint operation. In general terms, many of the de - ficiencies revealed in joint

  5. Bibliography of Documents Related to the Theory, Operation, Performance and Applications of Coaxial Plasma Guns. Revision

    DTIC Science & Technology

    1990-11-01

    V., Grunberger, L. and Prior, W., "Observation of Solar Flare Type Processes in the Laboratory," in Solar Magnetic Fields, Symposium No. 43 of the...RF/FUS/84/6, Associazione EURATOM--Comitato Nazionale Energia Nucleare sulla Fusione, Centro di Frascati, Rome, Italy, September 1984. Brzosko, J. S...Energy Deuteron Beam Generation in Plasma Focus," Report No. 80.5, Associazione EURATOM--Comitato Nazionale Energia Nucleare sulla Fusione, Centro di

  6. Misura della sezione d'urto totale e Dello scattering elastico all'energia Nel centro di massa di $$\\sqrt{s}=1.8$$ TeV (in Italian)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Paoletti, Riccardo

    La produzione di eventi elastici è stata misurata al Collider Tevatron del Fermi National Accelerator Laboratory (Batavia. 11.~ U .S.A.) alla energia nel centro di massa. di √s = 1800 GeV, nell'intervallo 0.06 < I t I< 0.24. Sono forniti dettagli sull'esperimento CDF che ha compiuto la misura e sui criteri di selezione degli eventi.

  7. Improving Regional Security in Central America: Military Engagement Options for Nicaragua

    DTIC Science & Technology

    2002-12-01

    Diálogo Centro-americano San José, Costa Rica No. 38 Marzo-Abril 1999 Ejércitos para preservar la paz y la democracia . Pedro Joaquín Chamorro...del Foro Civil Centroamericano para la Defensa y la Seguridad (FOCADES). (Declaration of Managua: Declaration of Managua: Constitution of the Central...State. Isacson, Adam 1998. Seguridad Cooperativa en Centroamérica. (Cooperative Security in Central America) Diálogo Centro-americano No. 35

  8. Development and Dissemination of the El Centro Health Disparities Measures Library.

    PubMed

    Mitrani, Victoria Behar; O'Day, Joanne E; Norris, Timothy B; Adebayo, Oluwamuyiwa Winifred

    2017-09-01

    This report describes the development and dissemination of a library of English measures, with Spanish translations, on constructs relevant to social determinants of health and behavioral health outcomes. The El Centro Measures Library is a product of the Center of Excellence for Health Disparities Research: El Centro, a program funded by the National Institute on Minority Health and Health Disparities of the U.S. National Institutes of Health. The library is aimed at enhancing capacity for minority health and health disparities research, particularly for Hispanics living in the United States and abroad. The open-access library of measures (available through www.miami.edu/sonhs/measureslibrary) contains brief descriptions of each measure, scoring information (where available), links to related peer-reviewed articles, and measure items in both languages. Links to measure websites where commercially available measures can be purchased are included, as is contact information for measures that require author permission. Links to several other measures libraries are hosted on the library website. Other researchers may contribute to the library. El Centro investigators began the library by electing to use a common set of measures across studies to assess demographic information, culture-related variables, proximal outcomes of interest, and major outcomes. The collection was expanded to include other health disparity research studies. In 2012, a formal process was developed to organize, expand, and centralize the library in preparation for a gradual process of dissemination to the national and international community of researchers. The library currently contains 61 measures encompassing 12 categories of constructs. Thus far, the library has been accessed 8,883 times (unique page views as generated by Google Analytics), and responses from constituencies of users and measure authors have been favorable. With the paucity of availability and accessibility of translated measures, behavioral nursing research focused on reducing health disparities can benefit from repositories of research instruments such as the El Centro Measures Library. © 2017 Sigma Theta Tau International.

  9. PREFACE: International Conference on Control and Synchronization of Dynamical Systems (CSDS-2005)

    NASA Astrophysics Data System (ADS)

    Pisarchik, Alexander N.

    2005-01-01

    This volume of Journal of Physics: Conference Series contains selected articles by the participants at the International Conference on Control and Synchronization of Dynamical Systems (CSDS-2005) organized by Centro de Investigaciones en Optica (CIO) in cooperation with the Society for Industrial and Applied Mathematics (SIAM), which was held in Leon, Guanajuato, Mexico on 4-7 October 2005. CSDS-2005 featured the latest research in nonlinear dynamics concentrating on the theory of control and synchronization of complex systems and its applications in different areas of science and engineering, including optics, electronics, mechanics, chemistry, medicine, economy, communication, etc. The conference brought together leading researchers, both theoreticians and experimentalists, from different fields of science and provided an excellent opportunity for sharing ideas and problems among specialists in controlling dynamical systems and synchronization. The meeting served a dual purpose: to expose the scientific community to the cutting edge of forefront research done by leaders in this area from as many as 25 countries and to attract the attention of Mexican researchers to this field of science. These proceedings are intended to be a record of this conference and to serve as a reference for future research which the conference hopes to have initiated. After the pioneering work on controlling chaos of E Ott, C Grebogi and J Yorke appeared in Physical Review Letters in 1990, the number of works on this topic grew tremendously. Our extensive bibliographic search among 110 peer reviewed journals yielded more than 1500 papers on controlling chaos and more than 2500 on synchronization of chaotic systems published during the last decade. The numbers of publications are still at their peaks that began to saturate, in 1998 and 2003, respectively. It is my pleasure to acknowledge the contribution of the program and organizing committees, the funding agencies and cooperating organizations, and the staff of CIO in organizing CSDS-2005. I am very grateful to all plenary and invited speakers for their acceptance of our invitation. Their contributions enhanced significantly the prestige of our conference. I would like to express my special thanks to Prof. Jürgen Kurths for his agreement to give a tutorial course on synchronization after the meeting. My sincere thanks are also due to Dr Fernando Mendoza-Santoyo, the General Director of CIO, and to Dr Ramón Rodriguez-Vera, the Research Director, for facilitating the use of institutional infrastructure, as well as for their interest and help in organization of the conference. I record my special thanks to Annette Torres for her invaluable secretarial work, to Bernardo Ruiz-Olvera for his help in visa processing, and to Carolina Arriola for designing the conference website and printed materials. I would also like to thank all my students for their assistance in holding the meeting. In the publication of the conference proceedings, I am grateful to our referees (V Aboites, V Afraimovich, F T Arecchi, A D'Anjou, C Grebogi, V Erofeyev, Hongjie Yu, L Kalyakin, A Karami, S K Dana, A K Das, J Kurths, A Loskutov, G Luna, R Meucci, C R Mirasso, C L Pando, P Parmananda, Qinhua Hu, R Rechtman, P K Roy, R Roy, N Rulkov, E A Sataev, A Shil'nikov, S Sinha, V M Somsikov, N N Verichev, U E Vincent, A Volkovskii, J Zebrowski) for their knowledgeable and careful comments, and to Dr Rider Jaimes-Reátegui and Dr Hugo Garcia-Lopez for helping me with the editorial process. Finally, I thank the Institute of Physics Editorial team for publishing these proceedings very rapidly and efficiently. International Program Committee V Afraimovich (Universidad de San Luis Potosi, Mexico) T F Arecchi (University of Firenze, Italy) C Grebogi (Universidad de Sao Paulo, Brazil) J Haus (University of Dayton, USA) (OSA representative) J Kurths (University of Potsdam, Germany) F Mendoza-Santoyo (Centro de Investigaciones en Optica, Mexico) (General Director) A N Pisarchik (Centro de Investigaciones en Optica, Mexico) (Chair) R Roy (University of Maryland, USA) (SIAM representative) S Sinha (Institute of Mathematical Sciences, India) Local Organizing Committee V Aboites (Centro de Investigaciones en Optica, Mexico) R Espinosa-Luna (Centro de Investigaciones en Optica, Mexico) J H García-López (Universidad de Guadalajara, Mexico) R Jaimes-Reátegui (Universidad de Guadalajara, Mexico) A V Kir'yanov (Centro de Investigaciones en Optica, Mexico) E Kourmychev (Centro de Investigaciones en Optica, Mexico) V J Pinto-Robledo (Centro de Investigaciones en Optica, Mexico) R Rodriguez-Vera (Centro de Investigaciones en Optica, Mexico) (Research Director) G V Vazquéz-García (Centro de Investigaciones en Optica, Mexico) Funding Agencies Consejo de Ciencia y Tecnología de Estado Guanajuato, Mexico Abdus Salam International Centre for Theoretical Physics, Trieste, Italy International Mathematical Union, USA Centro Latinoamericano de Física, Brazil Academia Mexicana de Ciencias, Mexico Fundación México—Estados Unidos para la Ciencia, Mexico Cooperating Organizations International Society for Optical Engineering American Physical Society Optical Society of America Institute of Physics

  10. Pre-clinical and Clinical Development of Low Dose Methamphetamine for the Treatment of Traumatic Brain Injury

    DTIC Science & Technology

    2014-12-01

    Aim 3: Secure FDA approval of a phase I/II clinical trial plan and obtain an amended IND in preparation for initiating human clinical testing in TBI...Neurology 6:193–201. Raineri M, Gonzalez B, Goitia B, Garcia-Rill E, Krasnova IN, Cadet JL, Urbano FJ, Bisagno V. 2012. Modafinil abrogates

  11. A More Realistic Approach to the Measurement of Occupational Interests in a Service Setting. Part 1. Form EZ.

    DTIC Science & Technology

    1979-12-01

    their engagement who use a specific outside job opportunity in support could have the reality of their plans evaluated by either previously recorded...programme. Factored data on this are now to hand 3 at the suggestion of P. J. Oswnld Nita Cherry, Linda Gatiss, John Urbano and will be discussed in

  12. Composición y estructura de un bosque tropical urbano en el karso norteno de Puerto Rico

    Treesearch

    E. López Machado; K. Soto Hidalgo; T. Heartsill-Scalley

    2012-01-01

    Tropical secondary forests provide many products, environmental services, and recreation. These forests have a set of biological features, such as their high productivity and a uniform composition of dominant tree species. To understand the composition and structure of a secondary forest in the northern karst zone, we selected the Santa Ana Environmental Center (CASA...

  13. A Novel Strategy to Inhibit Hedgehog Signaling and Control Growth of Androgen-Independent Prostate Cancer Cells

    DTIC Science & Technology

    2013-12-01

    M TIME PPC1 Volume of Spheroid Ctrl (respective media) .2% DMSO 10 uM Free Curcumin 20 uM Free Curcumin 10 uM Tagged Curcumin 20 uM Tagged... Curcumin FIGURE 6 Ctrl media 10uM FC 20uM FC 20uM TC 10uM TC 2% DMSO PC3 t0 Div 8 FIGURE 7 Phospho-p65 NFκB subunit expression decreased In

  14. Experience at the CENAM With Time and Frequency Standards Signals Received by the Global Positioning System (GPS)

    DTIC Science & Technology

    1996-12-01

    ORGANIZATION NAME(S) AND ADDRESS(ES) Centro Nacional de Metrologia , Cenam,Time and Frequency Division,Apdo. Postal 1-100 Centro,C.P. 76900, Queretaro...5.39 x10-" 5.89 x10-" 3.93 x10-" 2.15 x10-l1 1.17 x10-" 7.27 xl0- la MVAR 852 x10-" 8.67 x10-" 9.46 x10-" 1.23 x10-lo x10-lo 1.95 x10-lo

  15. Equatorial Scintillation Predictions from C/NOFS Planar Langmuir Probe Electron Density Fluctuation Data

    DTIC Science & Technology

    2014-09-05

    Brasil Tel: 55 21 3527 1682; Fax: 55 21 3527 1154 E-mail: epoc@cetuc.puc-rio.br FINAL PERFORMANCE REPORT Equatorial scintillation...Costa Centro de Estudos em Telecomunicações/CETUC Rua Marquês de São Vicente, 225 – Gávea 22451-900 Rio de Janeiro - RJ – Brasil Tel: 55 21 3527...Emanoel Costa Centro de Estudos em Telecomunicações/CETUC Rua Marquês de São Vicente, 225 – Gávea 22451-900 Rio de Janeiro - RJ – Brasil Tel: 55

  16. Where is the fuzz? Undetected Lyman α nebulae around quasars at z ~ 2.3

    NASA Astrophysics Data System (ADS)

    Herenz, Edmund Christian; Wisotzki, Lutz; Roth, Martin; Anders, Friedrich

    2015-04-01

    We observed a small sample of five radio-quiet quasars with integral field spectroscopy to search for possible extended emission in the Lyα line. We subtracted the quasar point sources using a simple point spread function (PSF) self-calibration technique that takes advantage of the simultaneous availability of spatial and spectral information. In four of the five objects we find no significant traces of extended Lyα emission beyond the contribution of the quasar nuclei itself, while in UM 247 there is evidence for a weak and spatially quite compact excess in the Lyα line at several kpc outside the nucleus. For all objects in our sample we estimated detection limits for extended, smoothly distributed Lyα emission by adding fake nebulosities into the datacubes and trying to recover them after PSF subtraction. Our observations are consistent with other studies showing that giant Lyα nebulae such as those found recently around some quasars are very rare. Lyα fuzz around typical radio-quiet quasars is fainter and less extended and is therefore much harder to detect. The faintness of these structures is consistent with the idea that radio-quiet quasars typically reside in dark matter haloes of modest masses. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).

  17. Industry Studies 2002: Construction

    DTIC Science & Technology

    2002-01-01

    Jacksonville, FL Rotary Club of San Juan, San Juan, PR Tren Urbano Subway Project, San Juan, PR U.S. Army South, San Juan, PR U.S. Coast Guard Housing Project...Bechtel Corporation (IBM Plant Construction Site), Shanghai American Chamber of Commerce, Shanghai Urban Planning Exhibit, Shanghai 3 INTRODUCTION The...of states have or are working on a statewide or agency-wide privatization plan , including California, Maryland, Massachusetts, Michigan and

  18. Translations on Narcotics and Dangerous Drugs No. 270.

    DTIC Science & Technology

    1976-11-04

    persons arrested were: Hugo Norberto Ammirante,30; Urbano Vicente Toledo, 31; Carlos Roberto Cejas, 28; Leandro Alberto Herrera, 27; and... Carlos Alberto Ignatier, 33. The ring brought cocaine from Bolivia and processed it in Salt a, selling it mainly to someone known as El Chuco who...Garcia. Some escaped to Brownsville, among them Inspector Carlos Morales who walked across the bridge and Supervisor Joaquin Cardenas who abandoned

  19. Urban Ecosystems. Environment Booklet 4. Teacher's Edition =Ecosist urbanos. Libro del medio ambiente 4. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  20. Assessment of operative times of multiple surgical specialties in a public university hospital.

    PubMed

    Costa, Altair da Silva

    2017-01-01

    To evaluate the indicators duration of anesthesia, operative time and time patients stay in the operating rooms of different surgical specialties at a public university hospital. It was done by a descriptive cross-sectional study based on the operating room database. The following stages were measured: duration of anesthesia, procedure time and patient length of stay in the room of the various specialties. We included surgeries carried out in sequence in the same room, between 7:00 a.m. and 5 p.m., either elective or emergency. We calculated the 80th percentile of the stages, where 80% of procedures were below this value. The study measured 8,337 operations of 12 surgical specialties performed within one year. The overall mean duration of anesthesia of all specialties was 178.12±110.46 minutes, and the 80th percentile was 252 minutes. The mean operative time was 130.45±97.23 minutes, and the 80th percentile was 195 minutes. The mean total time of the patient in the operating room was 197.30±113.71 minutes, and the 80th percentile was 285 minutes. Thus, the variation of the overall mean compared to the 80th percentile was 41% for anesthesia, 49% for surgeries and 44% for operating room time. In average, anesthesia took up 88% of the operating room period, and surgery, 61%. This study identified patterns in the duration of surgery stages. The mean values of the specialties can assist with operating room planning and reduce delays. Avaliar os indicadores de tempo da anestesia, da operação e da permanência do paciente em sala de diversas especialidades do centro cirúrgico de um hospital universitário. Foi realizado em estudo descritivo transversal a partir da base de dados do centro cirúrgico e mensuradas as seguintes etapas: duração de anestesia, tempo do procedimento e tempo de permanência do paciente em sala das diversas especialidades. Foram incluídas as operações realizadas em sequência na mesma sala, das 7h às 17h, eletivas ou de urgências. Realizamos o calculo do percentil 80 da duração das etapas, onde 80% dos procedimentos ficaram abaixo deste valor obtido. O estudo incluiu 8.337 operações realizadas no período de 1 ano de 12 especialidades cirúrgicas. A média geral da duração da anestesia de todas as especialidades foi de 178,12±110,46 minutos, e o percentil 80 foi de 252 minutos. A média do tempo operatório foi 130,45±97,23 minutos, e o percentil 80 foi de 195 minutos. A média do tempo total do paciente em sala operatória foi de 197,30±113,71 minutos, e o percentil 80 foi de 285 minutos. A variação da média geral em relação ao percentil 80 foi de 41% na anestesia, 49% nas operações e 44% no tempo de sala. Na média geral, a anestesia ocupou 88% do tempo de sala e a operação, 61%. Este estudo identificou padrões nas durações das etapas das operações. A informação das médias históricas das especialidades pode auxiliar no planejamento do centro cirúrgico e diminuir os atrasos.

  1. Attenuation of midinfrared free electron laser energy with eyewear

    NASA Astrophysics Data System (ADS)

    Joos, Karen M.; Gabella, William

    2005-04-01

    Purpose: To determine the attenuation of free electron laser (FEL) energy at several wavelengths through microscope objective and eyeglass lenses. Materials and Methods: The FEL at wavelengths of 2.3 um, 2.5 um, 3.0 um, 3.5 um, 4.0 um, 4.5 um, 5.0 um, 6.45 um, 7.0 um, 7.5 um, and 8.0 um was telescoped using a 500 mm nominal focal length lens and a 200 mm focal length lens. The beam had a final spot of about 3 mm and was passed through a 3 mm aperture and onto the 8 mm active area of a J9LP Molectron detector. The eyeglass sample was placed 3 cm in front of the detector. Energy readings were averaged over multiple pulses. Results: Attenuation varied greatly with wavelength and sample from a low attenuation of 0.46 dB, 90% transmission, for short wavelengths through common glass to greater than 60 dB attenuation (transmission at the detector noise level) for IR safe glass by Aura, Inc. Conclusion: Only the designated laser safety goggles effectively attenuate free electron laser energy at 2.3 um and 2.5 um. A microscope objective lens, polycarbonate, and silica glass eyewear is capable of effectively attenuating FEL energy at wavelengths greater than 4.5 um, but the polycarbonate lenses demonstrated material damage.

  2. Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas

    NASA Astrophysics Data System (ADS)

    Souza, T. R.; Baptista, R.

    2003-08-01

    As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

  3. Natives in Blue: The Employment of Armed Auxiliaries in the Philippines, 1899-1913

    DTIC Science & Technology

    2012-12-06

    responsibility of administering its accidental empire without any civil official on hand, without a plan to govern its new colonial possessions, and...moved well past normal lawlessness and approached open rebellion. Proper understanding of why operations were planned and executed as they were, and...lieutenants, Brigadier General Urbano Lacuna. On 23 March 1901, Aguinaldo, the self-proclaimed President of the Philippine Revolutionary Government

  4. Construction. A Report on the Industry

    DTIC Science & Technology

    2004-06-01

    Transportation and Tres Urbano Subway Project, San Juan, Puerto Rico U.S. Corps of Engineers, San Juan, Puerto Rico U.S. Corps of Engineers, Mobile...recently approved a plan to privatize construction of over 6,000 miles of expressways through the use of a build, transfer, and operate options.xl...security standards in Federal facilities, including an aggressive plan to build and renovate embassies and consular offices worldwide.xlv The

  5. [Spatial analysis of syphilis and gonorrhea infections in a Public Health Service in Madrid].

    PubMed

    Wijers, Irene G M; Sánchez Gómez, Amaya; Taveira Jiménez, Jose Antonio

    2017-06-21

    Sexually transmitted diseases are a significant public health problem. Within the Madrid Autonomous Region, the districts with the highest syphilis and gonorrhea incidences are part of the same Public Health Service (Servicio de Salud Pública del Área 7, SSPA 7). The objective of this study was to identify, by spatial analysis, clusters of syphilis and gonorrhea infections in this SSPA in Madrid. All confirmed syphilis and gonorrhea cases registered in SSPA 7 in Madrid were selected. Moran's I was calculated in order to identify the existence of spatial autocorrelation and a cluster analysis was performed. Clusters and cumulative incidences (CI) per health zone were mapped. The district with most cases was Centro (CI: 67.5 and 160.7 per 100.000 inhabitants for syphilis and gonorrhea, respectively) with the highest CI (120.0 and 322.6 per 100.000 inhabitants) in the Justicia health zone.91.6% of all syphilis cases and 89.6% of gonorrhea cases were among men who have sex with men (MSM). Moran's I was 0.54 and 0.55 (p=0.001) for syphilis and gonorrhea, respectively. For syphilis, a cluster was identified including the six health zones of the Centro district, with a relative risk (RR)of 6.66 (p=0.001). For gonorrhea, a cluster was found including the Centro district, three health zones of the Chamberí district and one of Latina (RR 5.05; p=0.001). Centro was the district with most cases of syphilis and gonorrhea and the most affected population were MSM. For both infections, clusters were found with an important overlap. By identifying the most vulnerable health zones and populations, these results can help to design public health measures for preventing sexually transmitted diseases.

  6. Left centro-parieto-temporal response to tool-gesture incongruity: an ERP study.

    PubMed

    Chang, Yi-Tzu; Chen, Hsiang-Yu; Huang, Yuan-Chieh; Shih, Wan-Yu; Chan, Hsiao-Lung; Wu, Ping-Yi; Meng, Ling-Fu; Chen, Chen-Chi; Wang, Ching-I

    2018-03-13

    Action semantics have been investigated in relation to context violation but remain less examined in relation to the meaning of gestures. In the present study, we examined tool-gesture incongruity by event-related potentials (ERPs) and hypothesized that the component N400, a neural index which has been widely used in both linguistic and action semantic congruence, is significant for conditions of incongruence. Twenty participants performed a tool-gesture judgment task, in which they were asked to judge whether the tool-gesture pairs were correct or incorrect, for the purpose of conveying functional expression of the tools. Online electroencephalograms and behavioral performances (the accuracy rate and reaction time) were recorded. The ERP analysis showed a left centro-parieto-temporal N300 effect (220-360 ms) for the correct condition. However, the expected N400 (400-550 ms) could not be differentiated between correct/incorrect conditions. After 700 ms, a prominent late negative complex for the correct condition was also found in the left centro-parieto-temporal area. The neurophysiological findings indicated that the left centro-parieto-temporal area is the predominant region contributing to neural processing for tool-gesture incongruity in right-handers. The temporal dynamics of tool-gesture incongruity are: (1) firstly enhanced for recognizable tool-gesture using patterns, (2) and require a secondary reanalysis for further examination of the highly complicated visual structures of gestures and tools. The evidence from the tool-gesture incongruity indicated altered brain activities attributable to the N400 in relation to lexical and action semantics. The online interaction between gesture and tool processing provided minimal context violation or anticipation effect, which may explain the missing N400.

  7. Clinical-Functional Vulnerability Index-20 (IVCF-20): rapid recognition of frail older adults.

    PubMed

    Moraes, Edgar Nunes de; Carmo, Juliana Alves do; Moraes, Flávia Lanna de; Azevedo, Raquel Souza; Machado, Carla Jorge; Montilla, Dalia Elena Romero

    2016-12-22

    To evaluate the adequacy of the Clinical-Functional Vulnerability Index-20, a rapid triage instrument to test vulnerability in Brazilian older adults, for the use in primary health care. The study included convenience sample of 397 patients aged older than or equal to 60 years attended at Centro de Referência para o Idoso (Reference Center for Older Adults) and of 52 older adults the same age attended at the community. The results of the questionnaire, consisting of 20 questions, were compared with those of the Comprehensive Geriatric Assessment, considered a reference for identifying frail older adults. Spearman's correlation was evaluated in the Clinical-Functional Vulnerability Index-20 with the Comprehensive Geriatric Assessment; the validity was verified by the area under the ROC curve; reliability was estimated by the percentage of agreement among evaluators and by the kappa coefficient, both with quadratic weighted. The cut-off point was obtained based on the higher accuracy criterion. Cronbach's alpha, a measure of internal consistency, was estimated. The Spearman's correlation coefficient was high and positive for both groups (0.792 for older adults attended at the Reference Center and 0.305 for older adults from the community [p < 0.001]). The area under the ROC curve for older adults attended at the Reference Center was substantial (0.903). The cut-off point obtained was six, and older adults with scores in Clinical-Functional Vulnerability Index-20 above that value had strong possibility of being frail. For older adults from the community, the quadratic weighted agreement among evaluators was 99.5%, and the global quadratic weighted kappa coefficient was 0.94. Cronbach's alpha was high for older adults attended at the Reference Center (0.861) and those attended at the community (0.740). The Clinical-Functional Vulnerability Index-20 questionnaire, in the sample examined, turned out to be positively correlated with the Comprehensive Geriatric Assessment, in addition to the results indicating a high degree of validity and reliability. Thus, the Clinical-Functional Vulnerability Index-20 proves to be viable as a triage instrument in the primary health care that identifies frail older adults (older adults at risk of weakening and frail older adults). Avaliar a adequação do Índice de Vulnerabilidade Clínico-Funcional-20 , instrumento de triagem rápida de vulnerabilidade em idosos brasileiros, para utilização pela atenção básica. O estudo incluiu amostra de conveniência de 397 pacientes com idade maior ou igual a 60 anos atendidos em um Centro de Referência para o Idoso e de 52 idosos da mesma idade atendidos na comunidade. Os resultados do questionário, constituído por 20 perguntas, foram comparados com aqueles da Avaliação Geriátrica Ampla, considerada referência para identificação do idoso frágil. Foi avaliada a correlação de Spearman do Índice de Vulnerabilidade Clínico-Funcional-20 com a Avaliação Geriátrica Ampla; a validade foi verificada pela área sob a curva ROC; a confiabilidade foi estimada pelo percentual de concordância entre avaliadores e coeficiente kappa, ambos com ponderação quadrática. Obteve-se ponto de corte com base no critério de maior acurácia. O alfa de Cronbach, medida de consistência interna, foi calculado. O coeficiente de correlação de Spearman foi elevado e positivo em ambos os grupos (0,792 para idosos atendidos no Centro de Referência para o Idoso e 0,305 para idosos da comunidade [p < 0,001]). A área sob a curva ROC para idosos atendidos no Centro de Referência para o Idoso foi substancial (0,903). O ponto de corte obtido foi seis e idosos com pontuação no Índice de Vulnerabilidade Clínico-Funcional-20 acima desse valor tinham forte possibilidade de serem frágeis. Para idosos da comunidade, a concordância ponderada quadrática entre avaliadores foi 99,5% e o coeficiente kappa ponderado quadrático global, 0,94. O alfa de Cronbach foi elevado para idosos atendidos no Centro de Referência para o Idoso (0,861) e da comunidade (0,740). O questionário do Índice de Vulnerabilidade Clínico-Funcional-20, na amostra analisada, mostrou ser positivamente correlacionado com a Avaliação Geriátrica Ampla, além de os resultados indicarem alto grau de validade e confiabilidade. Assim, o Índice de Vulnerabilidade Clínico-Funcional-20 se mostra viável como instrumento de rastreio na atenção básica que identifica o idoso com fragilidade (idoso em risco de fragilização e idoso frágil).

  8. [Current state of multidrug resistance in tuberculosis].

    PubMed

    Casal, M; Gutiérrez, J; Ruiz, P

    2000-06-01

    Given the current concern about multiresistance to drugs in tuberculosis, the data from a large study in two different centers are presented. At the Hospital Universitario Reina Sofía de Córdoba 71,359 clinical isolates of Mycobacterium tuberculosis were processed and at the Centro de Referencia de Micobacterias 2,350 cultures were studied. The percentage of total multiresistance at the Hospital Universitario was 6% from 1996-1998, and 6.7% at the Centro de Referencia in 1998. Although these figures are high, they are lower than in previous years and could indicate the beginning of a decreasing trend, following years of increasing in the 1990s.

  9. Translations on Environmental Quality, No. 152

    DTIC Science & Technology

    1977-11-01

    information was released during a press conference called by Manuel Diaz Dorado, under-secretary for Environmental Planning , Luis Urbano Juagueri, technical...seriousness of this threat, as well as what is being done and what plans have been made to eliminate the hazard. It is not superfluous to reiterate...the floating solids in the harbor; the use of a floating in- cinerator to collect and burn the garbage from ships anchored in the port; the planning

  10. Breast Cancer Research Training Grant

    DTIC Science & Technology

    1997-10-01

    students and answer questions and plan each student’s curriculum. Trainees are encouraged to consult any of the participating faculty for general advice...ROOM L301, REFRESHMENTS AT 1:00 September 20 Alexander Urbano Identification of novel endonucleases in drug- Department of Pathology & Laboratory...highly relevant. Plan to attend if you can. AER/cs Special Seminar 11/7/96 Dr. Harold Varmus •i• i .*: i •i •• • .iiil Boston University School of

  11. Densidad de desarrollo alta y baja en Puerto Rico

    Treesearch

    William A. Gould; Sebastian Martinuzzi; Olga M. Ramos Gonzalez

    2008-01-01

    Este mapa demuestra la distribución de terrenos de alta y baja densidad de desarrollo urbano en Puerto Rico (Martinuzzi et al. 2007). El mapa fue creado mediante el analisis de un mosaico de imagenes de satelite Landsat ETM+ de los años 2000 – 2003. La clasificacion no supervisada ISODATA (“Iterative Self-Organizing Data Analysis Technique”) (ERDAS 2003) fue utilizada...

  12. Translations on Narcotics and Dangerous Drugs, Number 291

    DTIC Science & Technology

    1977-03-23

    EL SOL DE MEXICO, 19 Feb 77) 53 Traffickers, Drugs, Weapons Seized in Tijuana (EXCELSIOR, 18 Feb 77) 55 Briefs Heroin Seizure in...women are Elena Urbano Hurtado, Celia Marina [last name indistinct] and Luz Angela Hoyos. The cocaine seized, which is 95 percent pure, has been...pesos. 8743 CSO: 5300 52 MEXICO TRAFFICKERS ARRESTED, WEAPONS AID DRUGS SEIZED Mexico City EL SOL DE MEXICO in Spanish 19 Feb 77 p 10-A

  13. The Assessment of Military Multitasking Performance: Validation of a Dual-Task and Multitask Protocol

    DTIC Science & Technology

    2014-08-01

    Revisions based on IRR findings and rater comments Charge of Quarters (CQ) Duty Requires the subject to organize and implement a plan in order to...to evaluate test burden) and malingering are planned . Where feasible, test-retest reliability for several of the tasks is being assessed during...in either a shopping mall or hospital lobby setting (Alderman, Burgess,Knight,&Henman, 2003;Cuberos- Urbano et al., 2013; Dawson et al., 2009

  14. The Gran Telescopio Canarias and Calar Alto Virtual Observatory compliant archives

    NASA Astrophysics Data System (ADS)

    Solano, Enrique; Gutiérrez, Raúl; Alacid, José Manuel; Jiménez-Esteban, Francisco; Velasco Trasmonte, Almudena

    2012-09-01

    The Gran Telescopio Canarias (GTC) and Calar Alto archives are the result of the collaboration agreements between the Centro de Astrobiología (CAB, INTA-CSIC)) and two entities: GRANTECAN S.A. and the Centro Astronómico Hispano Alemán (CAHA). The archives have been developed in the framework of the Spanish Virtual Observatory and are maintained by the Data Archive Unit at CAB. The archives contain both raw and science ready data and have been designed in compliance with the standards defined by the International Virtual Observatory Alliance (IVOA) which guarantees a high level of data accessibility and handling. In this paper we describe the main characteristics and functionalities of both archives.

  15. BME Estimation of Residential Exposure to Ambient PM10 and Ozone at Multiple Time Scales

    PubMed Central

    Yu, Hwa-Lung; Chen, Jiu-Chiuan; Christakos, George; Jerrett, Michael

    2009-01-01

    Background Long-term human exposure to ambient pollutants can be an important contributing or etiologic factor of many chronic diseases. Spatiotemporal estimation (mapping) of long-term exposure at residential areas based on field observations recorded in the U.S. Environmental Protection Agency’s Air Quality System often suffer from missing data issues due to the scarce monitoring network across space and the inconsistent recording periods at different monitors. Objective We developed and compared two upscaling methods: UM1 (data aggregation followed by exposure estimation) and UM2 (exposure estimation followed by data aggregation) for the long-term PM10 (particulate matter with aerodynamic diameter ≤ 10 μm) and ozone exposure estimations and applied them in multiple time scales to estimate PM and ozone exposures for the residential areas of the Health Effects of Air Pollution on Lupus (HEAPL) study. Method We used Bayesian maximum entropy (BME) analysis for the two upscaling methods. We performed spatiotemporal cross-validations at multiple time scales by UM1 and UM2 to assess the estimation accuracy across space and time. Results Compared with the kriging method, the integration of soft information by the BME method can effectively increase the estimation accuracy for both pollutants. The spatiotemporal distributions of estimation errors from UM1 and UM2 were similar. The cross-validation results indicated that UM2 is generally better than UM1 in exposure estimations at multiple time scales in terms of predictive accuracy and lack of bias. For yearly PM10 estimations, both approaches have comparable performance, but the implementation of UM1 is associated with much lower computation burden. Conclusion BME-based upscaling methods UM1 and UM2 can assimilate core and site-specific knowledge bases of different formats for long-term exposure estimation. This study shows that UM1 can perform reasonably well when the aggregation process does not alter the spatiotemporal structure of the original data set; otherwise, UM2 is preferable. PMID:19440491

  16. Modeling of two-storey precast school building using Ruaumoko 2D program

    NASA Astrophysics Data System (ADS)

    Hamid, N. H.; Tarmizi, L. H.; Ghani, K. D.

    2015-05-01

    The long-distant earthquake loading from Sumatra and Java Island had caused some slight damages to precast and reinforced concrete buildings in West Malaysia such as cracks on wall panels, columns and beams. Subsequently, the safety of existing precast concrete building is needed to be analyzed because these buildings were designed using BS 8110 which did not include the seismic loading in the design. Thus, this paper emphasizes on the seismic performance and dynamic behavior of precast school building constructed in Malaysia under three selected past earthquakes excitations ; El Centro 1940 North-South, El Centro East-West components and San Fernando 1971 using RUAUMOKO 2D program. This program is fully utilized by using prototype precast school model and dynamic non-linear time history analysis. From the results, it can be concluded that two-storey precast school building has experienced severe damage and partial collapse especially at beam-column joint under San Fernando and El Centro North-South Earthquake as its exceeds the allowable inter-storey drift and displacement as specified in Eurocode 8. The San Fernando earthquake has produced a massive destruction to the precast building under viscous damping, ξ = 5% and this building has generated maximum building displacement of 435mm, maximum building drift of 0.68% and maximum bending moment at 8458kNm.

  17. Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R

    PubMed Central

    Gravells, P; Hoh, L; Canovas, D; Rennie, I G; Sisley, K; Bryant, H E

    2011-01-01

    Background: Uveal melanoma (UM) is the most common primary intraocular tumour of adults, frequently metastasising to the liver. Hepatic metastases are difficult to treat and are mainly unresponsive to chemotherapy. To investigate why UM are so chemo-resistant we explored the effect of interstrand cross-linking agents mitomycin C (MMC) and cisplatin in comparison with hydroxyurea (HU). Methods: Sensitivity to MMC, cisplatin and HU was tested in established UM cell lines using clonogenic assays. The response of UM to MMC was confirmed in MTT assays using short-term cultures of primary UM. The expression of cytochrome P450 reductase (CYP450R) was analysed by western blotting, and DNA cross-linking was assessed using COMET analysis supported by γ-H2AX foci formation. Results: Both established cell lines and primary cultures of UM were resistant to the cross-linking agent MMC (in each case P<0.001 in Student's t-test compared with controls). In two established UM cell lines, DNA cross-link damage was not induced by MMC (in both cases P<0.05 in Students's t-test compared with damage induced in controls). In all, 6 out of 6 UMs tested displayed reduced expression of the metabolising enzyme CYP450R and transient expression of CYP450R increased MMC sensitivity of UM. Conclusion: We suggest that reduced expression of CYP450R is responsible for MMC resistance of UM, through a lack of bioactivation, which can be reversed by complementing UM cell lines with CYP450R. PMID:21386838

  18. Teaching Climate Science in Non-traditional Classrooms

    NASA Astrophysics Data System (ADS)

    Strybos, J.

    2015-12-01

    San Antonio College is the oldest, largest and centrally-located campus of Alamo Colleges, a network of five community colleges based around San Antonio, Texas with a headcount enrollment of approximately 20,000 students. The student population is diverse in ethnicity, age and income; and the Colleges understand that they play a salient role in educating its students on the foreseen impacts of climate change. This presentation will discuss the key investment Alamo Colleges has adopted to incorporate sustainability and climate science into non-traditional classrooms. The established courses that cover climate-related course material have historically had low enrollments. One of the most significant challenges is informing the student population of the value of this class both in their academic career and in their personal lives. By hosting these lessons in hands-on simulations and demonstrations that are accessible and understandable to students of any age, and pursuing any major, we have found an exciting way to teach all students about climate change and identify solutions. San Antonio College (SAC) hosts the Bill R. Sinkin Eco Centro Community Center, completed in early 2014, that serves as an environmental hub for Alamo Colleges' staff and students as well as the San Antonio community. The center actively engages staff and faculty during training days in sustainability by presenting information on Eco Centro, personal sustainability habits, and inviting faculty to bring their classes for a tour and sustainability primer for students. The Centro has hosted professors from diverse disciplines that include Architecture, Psychology, Engineering, Science, English, Fine Arts, and International Studies to bring their classes to center to learn about energy, water conservation, landscaping, and green building. Additionally, Eco Centro encourages and assists students with research projects, including a solar-hydroponic project currently under development with the support of a Re-energize grant. Lastly, the students also have a chance to observe the energy generated by the building's solar arrays compared to the energy taken from the grid.

  19. Brachial insertion of fully implantable venous catheters for chemotherapy: complications and quality of life assessment in 35 patients.

    PubMed

    Fonseca, Igor Yoshio Imagawa; Krutman, Mariana; Nishinari, Kenji; Yazbek, Guilherme; Teivelis, Marcelo Passos; Bomfim, Guilherme André Zottele; Cavalcante, Rafael Noronha; Wolosker, Nelson

    2016-01-01

    To prospectively evaluate the perioperative safety, early complications and satisfaction of patients who underwent the implantation of central catheters peripherally inserted via basilic vein. Thirty-five consecutive patients with active oncologic disease requiring chemotherapy were prospectively followed up after undergoing peripheral implantation of indwelling venous catheters, between November 2013 and June 2014. The procedures were performed in the operating room by the same team of three vascular surgeons. The primary endpoints assessed were early postoperative complications, occurring within 30 days after implantation. The evaluation of patient satisfaction was based on a specific questionnaire used in previous studies. In all cases, ultrasound-guided puncture of the basilic vein was feasible and the procedure successfully completed. Early complications included one case of basilic vein thrombophlebitis and one case of pocket infection that did not require device removal. Out of 35 patients interviewed, 33 (94.3%) would recommend the device to other patients. Implanting brachial ports is a feasible option, with low intraoperative risk and similar rates of early postoperative complications when compared to the existing data of the conventional technique. The patients studied were satisfied with the device and would recommend the procedure to others. Avaliar prospectivamente segurança perioperatória, complicações precoces e grau de satisfação de pacientes submetidos ao implante de cateteres centrais de inserção periférica pela veia basílica. Foram acompanhados prospectivamente e submetidos ao implante de cateteres de longa permanência de inserção periférica, entre novembro de 2013 e junho de 2014, 35 pacientes consecutivos com doença oncológica ativa necessitando de quimioterapia. Os procedimentos foram realizados em centro cirúrgico por uma mesma equipe composta por três cirurgiões vasculares. Os desfechos primários avaliados foram as complicações pós-operatórias precoces, ocorridas em até 30 dias após o implante. A avaliação do grau de satisfação foi realizada com base na aplicação de um questionário específico já utilizado em estudos prévios. Em todos os casos, a punção ecoguiada da veia basílica foi possível, e o procedimento foi concluído com sucesso. As complicações precoces observadas incluíram um caso de tromboflebite de basílica e um de infecção de bolsa, ambos tratados clinicamente sem necessidade de retirada do dispositivo. Dos 35 pacientes interrogados, 33 (94,3%) recomendariam o dispositivo para outras pessoas. A implantação do port braquial é uma opção factível, com baixo risco intraoperatório e taxas semelhantes de complicações pós-operatórias imediatas quando comparada a dados já existentes da técnica convencional. Os pacientes estudados apresentaram-se satisfeitos com o dispositivo e recomendariam o procedimento para outras pessoas.

  20. Short version of the Depression Anxiety Stress Scale-21: is it valid for Brazilian adolescents?

    PubMed

    Silva, Hítalo Andrade da; Passos, Muana Hiandra Pereira Dos; Oliveira, Valéria Mayaly Alves de; Palmeira, Aline Cabral; Pitangui, Ana Carolina Rodarti; Araújo, Rodrigo Cappato de

    2016-01-01

    To evaluate the interday reproducibility, agreement and validity of the construct of short version of the Depression Anxiety Stress Scale-21 applied to adolescents. The sample consisted of adolescents of both sexes, aged between 10 and 19 years, who were recruited from schools and sports centers. The validity of the construct was performed by exploratory factor analysis, and reliability was calculated for each construct using the intraclass correlation coefficient, standard error of measurement and the minimum detectable change. The factor analysis combining the items corresponding to anxiety and stress in a single factor, and depression in a second factor, showed a better match of all 21 items, with higher factor loadings in their respective constructs. The reproducibility values for depression were intraclass correlation coefficient with 0.86, standard error of measurement with 0.80, and minimum detectable change with 2.22; and, for anxiety/stress: intraclass correlation coefficient with 0.82, standard error of measurement with 1.80, and minimum detectable change with 4.99. The short version of the Depression Anxiety Stress Scale-21 showed excellent values of reliability, and strong internal consistency. The two-factor model with condensation of the constructs anxiety and stress in a single factor was the most acceptable for the adolescent population. Avaliar a reprodutibilidade interdias, a concordância e a validade do construto da versão reduzida da Depression Anxiety Stress Scale-21 aplicada a adolescentes. A amostra foi composta por adolescentes de ambos os sexos, com idades entre 10 e 19 anos, recrutados de escolas e centros esportivos. A validade de construto foi realizada por análise fatorial exploratória, e a confiabilidade foi calculada para cada construto, por meio de coeficiente de correlação intraclasse, erro padrão de medida e mudança mínima detectável. A análise fatorial combinando os itens correspondentes a ansiedade e estresse em um único fator, e depressão em um segundo fator apresentou melhor adequação de todos os 21 itens, com cargas fatoriais mais altas em seus respectivos construtos. Os valores de reprodutibilidade para a depressão foram coeficiente de correlação intraclasse com 0,86, erros padrão de medida com 0,80 e mudança mínima detectável com 2,22 e, para a ansiedade/estresse, foram coeficiente de correlação intraclasse com 0,82, erro padrão de medida com 1,80 e mudança mínima detectável com 4,99. A versão reduzida da Depression Anxiety Stress Scale-21 apresentou excelentes valores de confiabilidade e também uma forte consistência interna. O modelo de dois fatores com a condensação dos construtos ansiedade e estresse em um único fator foi o mais aceitável para a população adolescente.

  1. Emissions and prevention/control techniques for automobile body shops in Ciudad Juarez, Mexico

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jeffery, J.D.; Sager, M.

    1999-08-01

    Emissions of Volatile Organic Compounds (VOC) from automobile body repair shops are believed to be significant and to contribute to ozone nonattainment in El Paso, Texas and to violations of ozone air quality standards in Ciudad Juarez, Mexico. The Direccion de Desarrollo Urbano Y Ecologia (DDUE), (the local agency in Ciudad Juarez, Mexico) requested CICA's assistance in determining emissions from and identifying appropriate pollution prevention and control techniques for automobile body repair shops in Ciudad Juarez.

  2. Uveal melanoma hepatic metastases mutation spectrum analysis using targeted next-generation sequencing of 400 cancer genes.

    PubMed

    Luscan, A; Just, P A; Briand, A; Burin des Roziers, C; Goussard, P; Nitschké, P; Vidaud, M; Avril, M F; Terris, B; Pasmant, E

    2015-04-01

    Uveal melanoma (UM) is the most common malignant tumour of the eye. Diagnosis often occurs late in the course of disease, and prognosis is generally poor. Recently, recurrent somatic mutations were described, unravelling additional specific altered pathways in UM. Targeted next-generation sequencing (NGS) can now be applied to an accurate and fast identification of somatic mutations in cancer. The aim of the present study was to characterise the mutation pattern of five UM hepatic metastases with well-defined clinical and pathological features. We analysed the UM mutation spectrum using targeted NGS on 409 cancer genes. Four previous reported genes were found to be recurrently mutated. All tumours presented mutually exclusive GNA11 or GNAQ missense mutations. BAP1 loss-of-function mutations were found in three UMs. SF3B1 missense mutations were found in the two UMs with no BAP1 mutations. We then searched for additional mutation targets. We identified the Arg505Cys mutation in the tumour suppressor FBXW7. The same mutation was previously described in different cancer types, and FBXW7 was recently reported to be mutated in UM exomes. Further studies are required to confirm FBXW7 implication in UM tumorigenesis. Elucidating the molecular mechanisms underlying UM tumorigenesis holds the promise for novel and effective targeted UM therapies. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  3. [Prevention rather than cure: the emergence and first stage of the Centros de Higiene Infantil in Mexico City, 1922-1932].

    PubMed

    Alanís, Mercedes

    2015-01-01

    This article deals with the main features of the emergence and first ten years of the Centros de Higiene Infantil, facilities run by the Departamento de Salubridad Pública from 1922 on in Mexico City with the goal of providing care for mothers from pregnancy onwards and children from birth to two years of age. It reviews the actions that gave rise to this project and how it became established. It analyzes the structure of these centers, the characteristics of the mothers and children seen there and the functions performed by doctors and nurses, stressing the notion of preventing childhood illnesses, and ends with a first assessment of the effects and limitations of these centers.

  4. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals.

    PubMed

    Oliveira, Sandra Maria do Valle Leone de; Trajman, Anete; Paniago, Anamaria Mello Miranda; Motta-Castro, Ana Rita Coimbra; Ruffino-Netto, Antonio; Maciel, Ethel Leonor Noia; Croda, Julio; Bonecini-Almeida, Maria da Gloria

    2017-01-01

    To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model. Concordance was evaluated by determining the kappa statistic. Among the 81 patients evaluated, the tuberculin skin test results were positive in 18 (22.2%) of the patients, and the IGRA results were positive in 10 (12.3%), with a kappa of 0.62. The IGRA results were indeterminate in 22 (27.1%) of the patients (95% CI: 17.8-38.1%). The odds of obtaining indeterminate results were significantly higher in smokers (adjusted OR = 6.0; 95% CI: 1.4-26.7) and in samples stored for less than 35 days (adjusted OR = 14.0; 95% CI: 3.1-64.2). Patients with advanced immunosuppression (CD4+ T-cell count < 200 cells/mm3) were at a higher risk for indeterminate results (OR adjusted for smoking and inadequate duration of sample storage = 4.7; 95% CI: 0.91-24.0), although the difference was not significant. The high prevalence of indeterminate results can be a major limitation for the routine use of IGRAs in PLWHA. The need to repeat the test increases its costs and should be taken into account in cost-effectiveness studies. The processing of samples can significantly alter the results. Avaliar a frequência de resultados indeterminados de um interferon-gamma release assay (IGRA, ensaio de liberação de interferon-gama) e os fatores relacionados com esses resultados em pessoas vivendo com HIV/AIDS (PVHA). Foram avaliadas 81 PVHA na região Centro-Oeste do Brasil, por meio do teste tuberculínico e de um IGRA. Informações a respeito de variáveis sociodemográficas e clínicas foram obtidas por meio de questionários e prontuários médicos. A relação entre essas variáveis e os resultados indeterminados foi avaliada por meio do cálculo da OR ajustada em um modelo de regressão logística multivariada. A concordância foi avaliada por meio do coeficiente kappa. Os resultados do teste tuberculínico e do IGRA foram positivos em 18 (22,2%) e 10 (12,3%), respectivamente, dos 81 pacientes avaliados (κ = 0,62). O resultado do IGRA foi indeterminado em 22 (27,1%) dos pacientes (IC95%: 17,8-38,1%). A chance de resultados indeterminados foi significativamente maior em fumantes (OR ajustada = 6,0; IC95%: 1,4-26,7) e em amostras armazenadas durante menos de 35 dias (OR ajustada = 14,0; IC95%: 3,1-64,2). Pacientes com imunossupressão avançada (contagem de células T CD4+ < 200 células/mm3) apresentaram maior risco de resultados indeterminados (OR ajustada para tabagismo e tempo inadequado de armazenamento das amostras = 4,7; IC95%: 0,91-24,0), embora a diferença não tenha sido significativa. A alta prevalência de resultados indeterminados pode ser um grande obstáculo ao uso rotineiro de IGRAs em PVHA. A necessidade de repetir o teste aumenta seu custo e deve ser levada em conta em estudos da relação entre custo e eficácia. O processamento das amostras pode alterar significativamente os resultados.

  5. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA

    PubMed Central

    Kim, Jin Young; Carlson, Bradley A.; Xu, Xue-Ming; Zeng, Yu; Chen, Shawn; Gladyshev, Vadim N.; Lee, Byeong Jae; Hatfield, Dolph L.

    2011-01-01

    There are two isoforms of selenocysteine (Sec) tRNA[Ser]Sec that differ by a single methyl group, Um34. The non-Um34 isoform supports the synthesis of a subclass of selenoproteins, designated housekeeping, while the Um34 isoform supports the expression of another subclass, designated stress-related selenoproteins. Herein, we investigated the relationship between tRNA[Ser]Sec aminoacylation and Um34 synthesis which is the last step in the maturation of this tRNA. Mutation of the discriminator base at position 73 in tRNA[Ser]Sec dramatically reduced aminoacylation with serine, as did an inhibitor of seryl-tRNA synthetase, SB-217452. Although both the mutation and the inhibitor prevented Um34 synthesis, neither precluded the synthesis of any other of the known base modifications on tRNA[Ser]Sec following microinjection and incubation of the mutant tRNA[Ser]Sec transcript, or the wild type transcript along with inhibitor, in Xenopus oocytes. The data demonstrate that Sec tRNA[Ser]Sec must be aminoacylated for Um34 addition. The fact that selenium is required for Um34 methylation suggests that Sec must be attached to its tRNA for Um34 methylation. This would explain why selenium is essential for the function of Um34 methylase and provides further insights into the hierarchy of selenoprotein expression. PMID:21624347

  6. Thermodynamics of Anharmonic Systems: Uncoupled Mode Approximations for Molecules

    DOE PAGES

    Li, Yi-Pei; Bell, Alexis T.; Head-Gordon, Martin

    2016-05-26

    The partition functions, heat capacities, entropies, and enthalpies of selected molecules were calculated using uncoupled mode (UM) approximations, where the full-dimensional potential energy surface for internal motions was modeled as a sum of independent one-dimensional potentials for each mode. The computational cost of such approaches scales the same with molecular size as standard harmonic oscillator vibrational analysis using harmonic frequencies (HO hf). To compute thermodynamic properties, a computational protocol for obtaining the energy levels of each mode was established. The accuracy of the UM approximation depends strongly on how the one-dimensional potentials of each modes are defined. If the potentialsmore » are determined by the energy as a function of displacement along each normal mode (UM-N), the accuracies of the calculated thermodynamic properties are not significantly improved versus the HO hf model. Significant improvements can be achieved by constructing potentials for internal rotations and vibrations using the energy surfaces along the torsional coordinates and the remaining vibrational normal modes, respectively (UM-VT). For hydrogen peroxide and its isotopologs at 300 K, UM-VT captures more than 70% of the partition functions on average. By con trast, the HO hf model and UM-N can capture no more than 50%. For a selected test set of C2 to C8 linear and branched alkanes and species with different moieties, the enthalpies calculated using the HO hf model, UM-N, and UM-VT are all quite accurate comparing with reference values though the RMS errors of the HO model and UM-N are slightly higher than UM-VT. However, the accuracies in entropy calculations differ significantly between these three models. For the same test set, the RMS error of the standard entropies calculated by UM-VT is 2.18 cal mol -1 K -1 at 1000 K. By contrast, the RMS error obtained using the HO model and UM-N are 6.42 and 5.73 cal mol -1 K -1, respectively. For a test set composed of nine alkanes ranging from C5 to C8, the heat capacities calculated with the UM-VT model agree with the experimental values to within a RMS error of 0.78 cal mol -1 K -1 , which is less than one-third of the RMS error of the HO hf (2.69 cal mol -1 K -1) and UM-N (2.41 cal mol -1 K -1) models.« less

  7. Modeling of two-storey precast school building using Ruaumoko 2D program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hamid, N. H.; Tarmizi, L. H.; Ghani, K. D.

    The long-distant earthquake loading from Sumatra and Java Island had caused some slight damages to precast and reinforced concrete buildings in West Malaysia such as cracks on wall panels, columns and beams. Subsequently, the safety of existing precast concrete building is needed to be analyzed because these buildings were designed using BS 8110 which did not include the seismic loading in the design. Thus, this paper emphasizes on the seismic performance and dynamic behavior of precast school building constructed in Malaysia under three selected past earthquakes excitations ; El Centro 1940 North-South, El Centro East-West components and San Fernando 1971more » using RUAUMOKO 2D program. This program is fully utilized by using prototype precast school model and dynamic non-linear time history analysis. From the results, it can be concluded that two-storey precast school building has experienced severe damage and partial collapse especially at beam-column joint under San Fernando and El Centro North-South Earthquake as its exceeds the allowable inter-storey drift and displacement as specified in Eurocode 8. The San Fernando earthquake has produced a massive destruction to the precast building under viscous damping, ξ = 5% and this building has generated maximum building displacement of 435mm, maximum building drift of 0.68% and maximum bending moment at 8458kNm.« less

  8. STS-40 Exp. No. 192 urine monitoring system (UMS) on OV-102's middeck

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-40 Experiment No. 192, Fluid-Electrolyte Regulation During Space Flight, urine monitoring system (UMS) is set up on the middeck of Columbia, Orbiter Vehicle (OV) 102, at the side hatch. The UMS is attached to OV-102's waste collection system (WCS). The urine specimen tray with sample tubes appears to the right of the UMS equipment.

  9. In vitro investigation of head and neck cancer stem cell proportions and their changes following X-ray irradiation as a function of HPV status.

    PubMed

    Reid, Paul; Wilson, Puthenparampil; Li, Yanrui; Marcu, Loredana G; Staudacher, Alexander H; Brown, Michael P; Bezak, Eva

    2017-01-01

    Some head and neck squamous cell carcinomas (HNSCC) have a distinct aetiology, which depends on the presence of oncogenic human papilloma virus (HPV). Also, HNSCC contains cancer stem cells (CSCs) that have greater radioresistance and capacity to change replication dynamics in response to irradiation compared to non-clonogenic cells. Since there is limited data on CSCs in HNSCC as a function of HPV status, better understanding of their radiobiology may enable improved treatment outcome. Baseline and post-irradiation changes in CSC proportions were investigated by flow cytometry in a HPV-negative (UM-SCC-1) and a HPV-positive (UM-SCC-47) HNSCC cell line, using fluorescent staining with CD44/ALDH markers. CSC proportions in both irradiated and unirradiated cultures were compared for the two cell lines at various times post-irradiation. To assess repopulation of CSCs, untreated cultures were depleted of CD44+/ALDH+ cells and re-cultured for 3 weeks before flow cytometry analysis. CSC proportions in untreated cell lines were 0.57% (UM-SCC-1) and 2.87% (UM-SCC-47). Untreated cell lines depleted of CD44+/ALDH+ repopulated this phenotype to a mean of 0.15% (UM-SCC-1) and 6.76% (UM-SCC-47). All UM-SCC-47 generations showed elevated CSC proportions after irradiation, with the most significant increase at 2 days post-irradiation. The highest elevation in UM-SCC-1 CSCs was observed at 1 day post-irradiation in the 2nd generation and at 3 days after irradiation in the 3rd generation. When measured after 10 days, only the 3rd generation of UM-SCC-1 showed elevated CSCs. CSC proportions in both cell lines were elevated after exposure and varied with time post irradiation. UM-SCC-47 displayed significant plasticity in repopulating the CSC phenotype in depleted cultures, which was not seen in UM-SCC-1.

  10. Study of factors affecting growth and cold acclimation of Vitis callus cultures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deng, L.

    1987-01-01

    In vitro grape tissue culture initiation, growth, and cold acclimation were studied. Factors involved were genotypes, media, plant growth regulators, age, light, temperature, antioxidant, clearing and adsorbing agents, sucrose level, osmotic potential, ABA, chilling and freezing treatments. Murashige and Skoog (MS) medium containing 1 ..mu..M 2,4-d + 0.1 uM Ba, MS containing 1 uM 2,4-D, and woody plant medium containing 1 uM 2,4-D + 0.1 uM BA produced abundant callus tissue for most grape genotypes; either WPM or MS containing 1 uM BA stimulated shoot growth in all the 12 genotypes tested. Adding 1 uM abscisic acid (ABA) to themore » B5 medium with 1 uM 2,4-D and 0.5 uM BA enhanced growth and quality of Chancellor callus. /sup 3/H-ABA was taken up actively by callus tissue at 12 days after subculture, but by 20 d this effect disappeared. When /sup 14/C-sucrose was added to the medium. /sup 14/C level of cells reached a plateau after 48 h; this plateau was higher if ABA was also present in the medium. Cells on media containing ABA were larger in size, lighter in color, and more loosely connected.« less

  11. Self-perception of oral health in older adults from an urban population in Lisbon, Portugal.

    PubMed

    Carvalho, Catarina; Manso, Ana Cristina; Escoval, Ana; Salvado, Francisco; Nunes, Carla

    2016-08-22

    To analyze if the self-perception of oral health in the urban context is associated with sociodemographic factors that interfere in the life quality of oral health. Cross-sectional study with convenience sample of older individuals (65 years old or more) enrolled in the Agrupamento de Centros de Saúde de Lisboa Norte (ACES Lisboa Norte - Health Centers Groupings North Lisbon). The self-perception of oral health and associated life quality was evaluated by the Geriatric Oral Health Assessment Index and the individuals were classified according to sociodemographic characteristics. The internal consistency of the questionnaire was evaluated by Cronbach's alpha (α). Later, we used binary logistic regression models to characterize the factors associated with the self-perception of oral health, considering the sociodemographic variables and the older adults' clinical conditions of oral health and establishing the crude and adjusted (to age) odds ratios and their 90% confidence intervals. A total of 369 older adults participated in this study, with an average age of 74.2 years (SD = 6.75); 62.9% were female. On average, the index was moderated, with tendency to be high: 32.9 (SD = 3.6; 12-36 interval). The Cronbach's alpha was high: 0.805. Age, marital status, and the last dental appointment were the factors significantly associated with self-perception of oral health. The study shows that these individuals have a moderate, with tendency to high, self-perception of oral health. The self-perception of oral health assessment allowed us to identify the main associated sociodemographic factors. This instrument can help guiding planning strategies and oral health promotion directed toward a better life quality for this population group. Analisar se a autopercepção de saúde bucal em contexto urbano está associada aos factores sociodemográficos que interferem na qualidade de vida da saúde bucal. Estudo transversal com amostra de conveniência de indivíduos idosos (65 anos ou mais) inscritos no Agrupamento de Centros de Saúde de Lisboa Norte. A autopercepção da saúde bucal e qualidade de vida associada foi avaliada pelo índice de avaliação da saúde bucal em idosos (Geriatric Oral Health Assessment Index) e os indivíduos foram classificados de acordo com as características sociodemográficas. A consistência interna do questionário foi avaliada por meio do alfa (α) de Cronbach. Posteriormente, foram utilizados modelos de regressão logística binária para caracterizar os factores associados com a autopercepção de saúde bucal considerando as variáveis sociodemográficas e de condições clínicas de saúde bucal dos idosos e determinados os odds ratios bruto e ajustado (à idade) e respectivos intervalos de confiança a 90%. Participaram 369 idosos, com média de idade de 74,2 anos (DP = 6,75); 62,9% eram do sexo feminino. Em média, o índice foi moderado com tendência a elevado: 32,9 (DP = 3,6; intervalo 12-36). O alfa de Cronbach foi elevado: 0,805. A idade, o estado civil e a última consulta de Medicina Dentária foram os factores significativamente associados a autopercepção da saúde bucal. O estudo mostra que esses indivíduos apresentam uma autopercepção de saúde bucal moderada, com tendência a elevada. A avaliação da autopercepção da saúde bucal permitiu identificar os principais factores sociodemográficos associados. Este instrumento pode contribuir para orientar as estratégias de planejamento e promoção da saúde bucal direcionadas para uma melhor qualidade de vida deste grupo populacional.

  12. Three-frequency Nd:YAG laser for dental treatment

    NASA Astrophysics Data System (ADS)

    Kadlecová, Martina; Dostálová, Tat'jana; Jelínková, Helena; Němec, Michal; Å ulc, Jan; Fibrich, Martin; Bradna, Pavel; Nejezchleb, Karel; Kapitch, Nickalai; Å koda, Václav

    2018-02-01

    In the last decade, lasers found a number of indications in dentistry. However, there is still one problem: the narrow spectrum of usefulness for individual radiation wavelengths. The aim of our study is to demonstrate the use of a compact three-frequency pulsed Nd-YAG laser for more than one treatment, namely disinfection, coagulation, selective ablation, and soft tissue removal. The laser wavelengths and the maximal energies achieved were the following: 1.06 um, 1.32 um, 1.44 um and 830 mJ, 425 mJ, and 200 mJ, respectively. It has been found that all of the investigated wavelengths exhibit disinfection properties. Moreover, radiation of 1.06 um wavelength removes soft tissue and exhibits also coagulation properties. Radiation of 1.44 um is most useful for selective ablation of initial caries and disinfection, and 1.32 um radiation can be used for precise ablation when higher energy is applied.

  13. Recovery Act: Novel Kerf-Free PV Wafering that provides a low-cost approach to generate wafers from 150um to 50um in thickness

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fong, Theodore E.

    2013-05-06

    The technical paper summarizes the project work conducted in the development of Kerf-Free silicon wafering equipment for silicon solar wafering. This new PolyMax technology uses a two step process of implantation and cleaving to exfoliate 50um to 120um wafers with thicknesses ranging from 50um to 120um from a 125mm or 156mm pseudo-squared silicon ingot. No kerf is generated using this method of wafering. This method of wafering contrasts with the current method of making silicon solar wafers using the industry standard wire saw equipment. The report summarizes the activity conducted by Silicon Genesis Corporation in working to develop this technologymore » further and to define the roadmap specifications for the first commercial proto-type equipment for high volume solar wafer manufacturing using the PolyMax technology.« less

  14. USSR Report, International Affairs, The Working Class and the Contemporary World, Number 2, March-April 1986.

    DTIC Science & Technology

    1986-07-31

    3. Ibid., p 36. 4. "Yearbook of Labor Statistics. 1984," Geneva, 1984, p 827; G. Farrel, "Mercado de trabajo urbano y el movimiento sindiecal...Frente de liberacion nacional y social," Buenos .Aires, 1984, p 51. 10. EL PERIODISTA DE BUENOS AIRES, Buenos Aires, 1985, No 61, p 6. 11. OPINION...documents of the 27th CPSU Congress correctly point out, has set difficult tasks "for the young and rapidly growing working class in Asia , Africa and

  15. West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 4. Portuguese Perspectives on Defense, Deterrence and Strategy.

    DTIC Science & Technology

    1984-05-16

    in U.S. military planning , the West has to face growing threats in the peripheral zones, namely in those that are essential to the supply of raw...to a re-definition of U.S. strategic planning . In accordance with the ’Maritime strategy" of deployment from the U.S. territory of important military...Socialist Party, and the editor of the Communist daily, O’Diario, Miguel Urbano Rodriques. Neutralist doctrines are abundantly expressed in Liber 25

  16. Metals in some lagoons of Mexico.

    PubMed

    Vazquez, F G; Sharma, V K; Alexander, V H; Frausto, C A

    1995-02-01

    The concentrations of metals, Cd, Cu, Fe, Mn, Ni, Pb, and Zn were determined in some lagoons to establish the level of metal pollution. The lagoons studied were Alvarado lagoon, Veracruz; San Andres lagoon, Tamaulipas; and Terminos lagoon, Campeche. The concentrations were determined in water, oyster (Crassostrea virginica), and sediments. Metals were accumulated in either oysters or sediments. Cu and Zn were higher in oysters and Fe and Mn were higher in sediments. The results in water samples were compared with the limit established by the Secretaria de Ecologia and Desarrollo Urbano Report and briefly discussed.

  17. Towards reducing the impacts of unwanted movements on identification of motion intentions.

    PubMed

    Li, Xiangxin; Chen, Shixiong; Zhang, Haoshi; Samuel, Oluwarotimi Williams; Wang, Hui; Fang, Peng; Zhang, Xiufeng; Li, Guanglin

    2016-06-01

    Surface electromyogram (sEMG) has been extensively used as a control signal in prosthesis devices. However, it is still a great challenge to make multifunctional myoelectric prostheses clinically available due to a number of critical issues associated with existing EMG based control strategy. One such issue would be the effect of unwanted movements (UMs) that are inadvertently done by users on the performance of movement classification in EMG pattern recognition based algorithms. Since UMs are not considered in training a classifier, they would decay the performance of a trained classifier in identifying the target movements (TMs), which would cause some undesired actions in control of multifunctional prostheses. In this study, the impact of UMs was systemically investigated in both able-bodied subjects and transradial amputees. Our results showed that the UMs would be unevenly classified into all classes of the TMs. To reduce the impact of the UMs on the performance of a classifier, a new training strategy that would categorize all possible UMs into a new movement class was proposed and a metric called Reject Ratio that is a measure of how many UMs is rejected by a trained classifier was adopted. The results showed that the average Reject Ratio across all the participants was greater than 91%, meanwhile the average classification accuracy of TMs was above 99% when UMs occurred. This suggests that the proposed training strategy could greatly reduce the impact of UMs on the performance of the trained classifier in identifying the TMs and may enhance the robustness of myoelectric control in clinical applications. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma

    PubMed Central

    Landreville, Solange; Agapova, Olga A.; Matatall, Katie A.; Kneass, Zachary T.; Onken, Michael D.; Lee, Ryan S.; Bowcock, Anne M.; Harbour, J. William

    2011-01-01

    Purpose Metastasis is responsible for the death of most cancer patients, yet few therapeutic agents are available which specifically target the molecular events that lead to metastasis. We recently showed that inactivating mutations in the tumor suppressor gene BAP1 are closely associated with loss of melanocytic differentiation in uveal melanoma and metastasis (UM). The purpose of this study was to identify therapeutic agents that reverse the phenotypic effects of BAP1 loss in UM. Experimental Design In silico screens were performed to identify therapeutic compounds predicted to differentiate UM cells using Gene Set Enrichment Analysis and Connectivity Map databases. Valproic acid, trichostatin A, LBH-589 and suberoylanilide hydroxamic acid were evaluated for their effects on UM cells using morphologic evaluation, MTS viability assays, BrdU incorporation, flow cytometry, clonogenic assays, gene expression profiling, histone acetylation and ubiquitination assays, and a murine xenograft tumorigenicity model. Results HDAC inhibitors induced morphologic differentiation, cell cycle exit, and a shift to a differentiated, melanocytic gene expression profile in cultured UM cells. Valproic acid inhibited the growth of UM tumors in vivo. Conclusions These findings suggest that HDAC inhibitors may have therapeutic potential for inducing differentiation and prolonged dormancy of micrometastatic disease in UM. PMID:22038994

  19. Mathematisches Bewusstsein

    NASA Astrophysics Data System (ADS)

    Kaenders, Rainer; Kvasz, Ladislav

    Wenn jemand sagt, dass ein Bus um 9 Uhr abfährt - weiß man es dann? Angenommen, man ist darüber unterrichtet, dass die Busse unter der Woche immer zur vollen Stunde abfahren - von 7 Uhr morgens bis 7 Uhr abends, weiß man es dann mit dem Wissen um diese allgemeine Regel besser, dass der Bus um 9 Uhr abfährt? Macht es einen Unterschied, ob man den Fahrplan erstellt, den Bus lenkt oder nur mitfährt, um sich dieser Tatsache bewusst zu sein?

  20. VizieR Online Data Catalog: YSOs in California Molecular Cloud (Lada+, 2017)

    NASA Astrophysics Data System (ADS)

    Lada, C. J.; Lewis, J. A.; Lombardi, M.; Alves, J.

    2018-01-01

    The CMC was observed by the all-sky Planck observatory and by the Herschel Space Observatory as part of the "Auriga-California" program (Harvey et al. 2013, Cat J/ApJ/764/133). The Herschel data we used consisted of observations obtained in parallel mode simultaneously using the PACS and SPIRE instruments. For the purposes of this study we use Herschel observations made in the PACS 160um band, and the SPIRE 250um, 350um and 500um bands. (1 data file).

  1. An ethical leadership program for nursing unit managers.

    PubMed

    Jeon, Sang Hee; Park, Mihyun; Choi, Kyungok; Kim, Mi Kyoung

    2018-03-01

    The aims of this study were to evaluate the effect of an ethical leadership program (ELP) on ethical leadership, organizational citizenship behavior (OCB), and job outcomes of nursing unit managers (UMs) and to examine changes in staff nurses' perception about UMs' EL, OCB, job outcomes, and ethical work environments (EWEs) post-ELP. A quasi-experimental (pre- and post-test design) study conducted six-month intervention (ELP) using self-reported UM survey (n=44), and staff nurses (n=158) were randomly extracted by two steps. The Korean version of Ethical Leadership at Work for UMs' self-ethical leadership, the Ethical Leadership Scale for staff nurses' perceived ethical leadership, a 19-item OCB scale, and six dimensions of the medium-sized Copenhagen Psychosocial Questionnaire II for job outcomes and EWEs were administered at baseline and post-intervention. UMs' ethical leadership scores differed significantly over time in people orientation (p=0.041) and concern for ethical leadership sustainability (p=0.002) adjusting for UM experience duration and nursing unit type. Total mean and level of power-sharing of ethical leadership among UMs with <5years of UM experience improved significantly over time. Of staff nurses' perception changes about UMs' ethical leadership, OCB, job outcomes, and EWEs, significant improvement over time appeared only in EWEs' work influence level (p=0.007). This study provides useful information for clinical ELP development and examining the program's effect on leadership skills and followers' outcomes. Program facilitation relies on practical training methods, participant motivation, and assessment outcome designs by controlling clinical confounding factors. Findings have implications as an attempt for intervention to promote competencies related to ethical leadership of nursing unit managers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. ENDOSCOPIC SLEEVE GASTROPLASTY FOR OBESITY TREATMENT: TWO YEARS OF EXPERIENCE.

    PubMed

    Lopez-Nava, Gontrand; Galvão, M P; Bautista-Castaño, I; Fernandez-Corbelle, J P; Trell, M; Lopez, N

    2017-01-01

    Bariatric endoscopic techniques are minimally invasive and induce gastric volume reduction to treat obesity. Aim : To evaluate endoscopic sleeve gastroplasty (Apollo method) using a suturing method directed at the greater curvature, as well as the perioperative care, two year safety and weight loss. Prospective single-center study over 154 patients (108 females) using the endoscopic sleeve gastroplasty procedure under general anesthesia with overnight inpatient observation. Of the154 initial patients, 143 were available for 1-month of follow-up, 133 for 6-month, 64 for 12-month and 28 completed the 24 month assessment. Follow-up was carried out by a multidisciplinary team (nutritionist and psychologist). Outcomes evaluated were: change in BMI; change in body weight (TBWL); % of loss of initial body weight (%TBWL); % of excess body weight loss (%EWL) (segregated in > or <25% and adverse effects. Voluntary oral contrasted radiological examinations were scheduled to assess the gastroplasty at different times post-procedure. Mean age was 44.9 (23-69) years. At 24 months after the procedure baseline mean BMI change from 38.3 to 30.8 kg/m2. TBWL, %TBWL and %EWL were of 21.3 kg, 19.5% and 60.4% respectively. 85.7% of patients achieve the goal of >25% %EWL. There were no mayor adverse events intraprocedure or during the 24 months of follow-up . Endoscopic sleeve gastroplasty with regular monitoring by a multidisciplinary team can be considered an effective, safe and well tolerated procedure for obesity treatment, at least for two years of follow-up. As técnicas de endoscopia bariátrica são minimamente invasivas e induzem à redução do volume gástrico para tratar a obesidade. Avaliar a gastroplastia sleeve endoscópica (método Apollo) usando um método de sutura direcionado para a grande curvatura, bem como os cuidados perioperatórios, segurança em dois anos e perda de peso. Estudo prospectivo em um único centro com 154 pacientes (108 mulheres) usando o procedimento endoscópico de gastroplastia sleeve sob anestesia geral com observação do paciente internado durante a noite. Dos 154 pacientes iniciais, 143 estiveram disponíveis para acompanhamento de um mês, 133 durante seis meses, 64 durante 12 meses e 28 completaram a avaliação de 24 meses. O acompanhamento foi realizado por equipe multidisciplinar (nutricionista e psicólogo). Foram avaliados nos resultados as mudanças no IMC, no peso corporal (TWBL), no % de perda do peso corporal inicial (% TBWL) no % de excesso de perda de peso corporal (%EWL) segregado em > ou < 25% e efeitos adversos. Estudos radiológicos contratados orais voluntários foram programados para avaliar a gastroplastia em diferentes tempos após o procedimento. A idade média foi de 44,9 anos (23-69). Aos 24 meses após o procedimento a linha de base média do IMC mudou de 38,3 para 30,8 kg/m2. O TBWL, %TBWL e %EWL foram de 21,3 kg, 19,5% e 60,4%, respectivamente, e 85,7% dos pacientes alcançaram o objetivo de >25% EWL. Não houve eventos adversos graves peroperatórios ou durante os 24 meses de acompanhamento. A gastroplastia sleeve endoscópica com monitoramento regular por equipe multidisciplinar pode ser considerado procedimento eficaz, seguro e bem tolerado para o tratamento de pacientes com obesidade, pelo menos nos dois anos de acompanhamento.

  3. Laminar flow assisted anisotropic bacteria absorption for chemotaxis delivery of bacteria-attached microparticle

    NASA Astrophysics Data System (ADS)

    Huh, Keon; Oh, Darong; Son, Seok Young; Yoo, Hyung Jung; Song, Byeonghwa; Cho, Dong-il Dan; Seo, Jong-Mo; Kim, Sung Jae

    2016-12-01

    The concepts of microrobots has been drawn significant attentions recently since its unprecedented applicability in nanotechnology and biomedical field. Bacteria attached microparticles presented in this work are one of pioneering microrobot technology for self-propulsion or producing kinetic energy from ambient for their motions. Microfluidic device, especially utilizing laminar flow characteristics, were employed for anisotropic attachment of Salmonella typhimurium flagellated chemotactic bacteria to 30 um × 30 um and 50 um × 50 um microparticles that made of biodegradable polymer. Any toxic chemicals or harmful treatments were excluded during the attachment process and it finished within 100 s for the anisotropic attachment. The attachments were directly confirmed by fluorescent intensity changes and SEM visualization. Chemotaxis motions were tracked using aspartate and the maximum velocity of the bacteria-attached microrobot was measured to be 5 um/s which is comparable to prior state of art technologies. This reusable and scalable method could play a key role in chemotaxis delivery of functional microparticles such as drug delivery system.

  4. Unique Spectroscopy and Imaging of Terrestrial Planets with JWST

    NASA Astrophysics Data System (ADS)

    Villanueva, Geronimo Luis; JWST Mars Team

    2017-06-01

    In this talk, I will present the main capabilities of the James Webb Space Telescope (JWST) for performing observations of terrestrial planets, using Mars as a test case. The distinctive vantage point of JWST at the Sun-Earth Lagrange point (L2) will allow sampling the full observable disk, permitting the study of short-term phenomena, diurnal processes (across the East-West axis) and latitudinal processes between the hemispheres (including seasonal effects) with excellent spatial resolutions (0.07 arcsec at 2 um). Spectroscopic observations will be achievable in the 0.7-5 um spectral region with NIRSpec at a maximum resolving power of 2700, and with 8000 in the 1-1.25 um range. Imaging will be attainable with NIRCam at 4.3 um and with two narrow filters near 2 um, while the nightside will be accessible with several filters in the 0.5 to 2 um. Such a powerful suite of instruments will be a major asset for the exploration and characterization of Mars, and terrestrial planets in general. Some science cases include the mapping of the water D/H ratio, investigations of the Martian mesosphere via the characterization of the non-LTE CO2 emission at 4.3 um, studies of chemical transport via observations of the O2 nightglow at 1.27 um, high cadence mapping of the variability dust and water ice clouds, and sensitive searches for trace species and hydrated features on the planetary surface.

  5. Development and External Validation of a Prognostic Nomogram for Metastatic Uveal Melanoma

    PubMed Central

    Valpione, Sara; Moser, Justin C.; Parrozzani, Raffaele; Bazzi, Marco; Mansfield, Aaron S.; Mocellin, Simone; Pigozzo, Jacopo; Midena, Edoardo; Markovic, Svetomir N.; Aliberti, Camillo; Campana, Luca G.; Chiarion-Sileni, Vanna

    2015-01-01

    Background Approximately 50% of patients with uveal melanoma (UM) will develop metastatic disease, usually involving the liver. The outcome of metastatic UM (mUM) is generally poor and no standard therapy has been established. Additionally, clinicians lack a validated prognostic tool to evaluate these patients. The aim of this work was to develop a reliable prognostic nomogram for clinicians. Patients and Methods Two cohorts of mUM patients, from Veneto Oncology Institute (IOV) (N=152) and Mayo Clinic (MC) (N=102), were analyzed to develop and externally validate, a prognostic nomogram. Results The median survival of mUM was 17.2 months in the IOV cohort and 19.7 in the MC cohort. Percentage of liver involvement (HR 1.6), elevated levels of serum LDH (HR 1.6), and a WHO performance status=1 (HR 1.5) or 2–3 (HR 4.6) were associated with worse prognosis. Longer disease-free interval from diagnosis of UM to that of mUM conferred a survival advantage (HR 0.9). The nomogram had a concordance probability of 0.75 (SE .006) in the development dataset (IOV), and 0.80 (SE .009) in the external validation (MC). Nomogram predictions were well calibrated. Conclusions The nomogram, which includes percentage of liver involvement, LDH levels, WHO performance status and disease free-interval accurately predicts the prognosis of mUM and could be useful for decision-making and risk stratification for clinical trials. PMID:25780931

  6. VizieR Online Data Catalog: A dust model for bet Pic from 0.58 to 870um (Ballering+, 2016)

    NASA Astrophysics Data System (ADS)

    Ballering, N. P.; Su, K. Y. L.; Rieke, G. H.; Gaspar, A.

    2016-08-01

    β Pic was imaged with the HST/STIS CCD in coronagraphic (50CORON) mode under program GO-12551 (PI: Apai), and the results of these observations were published in Apai et al. (2015ApJ...800..136A). The instrument bandpass is set by the response of the CCD and centered at 0.58um. We searched the HST archive and found previously unpublished observations of β Pic with the WFC3 instrument in the IR channel (filter F110W at ~1.16um) from program GO-11150 (PI: Graham). The Spitzer/MIPS observations of β Pic were taken under the Spitzer Guaranteed Time Observing Program 90 (PI: M. Werner). The data at all three bands (24, 70, and 160um) are published here for the first time. Two sets of 24um observations were obtained. The first set was obtained on 2004 March 20, the second set of data was obtained on 2004 April 11. Two sets of 70um observations were obtained. The first set was obtained on 2004 April 12. The second set was obtained on 2005 April 4. Herschel/PACS 70um scan map observations of β Pic (PI G. Olofsson, observation IDs 1342186612 and 1342186613) were published by Vandenbussche et al. (2010A&A...518L.133V). We used the ALMA 870um continuum image previously published by Dent et al. (2014Sci...343.1490D). (1 data file).

  7. The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.

    PubMed

    Selma, María V; González-Sarrías, Antonio; Salas-Salvadó, Jordi; Andrés-Lacueva, Cristina; Alasalvar, Cesarettin; Örem, Asım; Tomás-Barberán, Francisco A; Espín, Juan C

    2018-06-01

    Urolithins are microbial metabolites produced after consumption of ellagitannin-containing foods such as pomegranates and walnuts. Parallel to isoflavone-metabolizing phenotypes, ellagitannin-metabolizing phenotypes (urolithin metabotypes A, B and 0; UM-A, UM-B and UM-0, respectively) can vary among individuals depending on their body mass index (BMI), but correlations between urolithin metabotypes (UMs) and cardiometabolic risk (CMR) factors are unexplored. We investigated the association between UMs and CMR factors in individuals with different BMI and health status. UM was identified using UPLC-ESI-qToF-MS in individuals consuming pomegranate or nuts. The associations between basal CMR factors and the urine urolithin metabolomic signature were explored in 20 healthy normoweight individuals consuming walnuts (30 g/d), 49 healthy overweight-obese individuals ingesting pomegranate extract (450 mg/d) and 25 metabolic syndrome (MetS) patients consuming nuts (15 g-walnuts, 7.5 g-hazelnuts and 7.5 g-almonds/d). Correlations between CMR factors and urolithins were found in overweight-obese individuals. Urolithin-A (mostly present in UM-A) was positively correlated with apolipoprotein A-I (P ≤ 0.05) and intermediate-HDL-cholesterol (P ≤ 0.05) while urolithin-B and isourolithin-A (characteristic from UM-B) were positively correlated with total-cholesterol, LDL-cholesterol (P ≤ 0.001), apolipoprotein B (P ≤ 0.01), VLDL-cholesterol, IDL-cholesterol, oxidized-LDL and apolipoprotein B:apolipoprotein A-I ratio (P ≤ 0.05). In MetS patients, urolithin-A only correlated inversely with glucose (P ≤ 0.05). Statin-treated MetS patients with UM-A showed a lipid profile similar to that of healthy normoweight individuals while a poor response to lipid-lowering therapy was observed in MB patients. UMs are potential CMR biomarkers. Overweight-obese individuals with UM-B are at increased risk of cardiometabolic disease, whereas urolithin-A production could protect against CMR factors. Further research is warranted to explore these associations in larger cohorts and whether the effect of lipid-lowering drugs or ellagitannin-consumption on CMR biomarkers depends on individuals' UM. NCT01916239 (https://clinicaltrials.gov/ct2/show/NCT01916239) and ISRCTN36468613 (http://www.isrctn.com/ISRCTN36468613). Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  8. The legacy of care as reflexive learning.

    PubMed

    García, Marta Rodríguez; Moya, Jose Luis Medina

    2016-06-14

    to analyze whether the tutor's use of reflexive strategies encourages the students to reflect. The goal is to discover what type of strategies can help to achieve this and how tutors and students behave in the practical context. a qualitative and ethnographic focus was adopted. Twenty-seven students and 15 tutors from three health centers participated. The latter had received specific training on reflexive clinical tutoring. The analysis was developed through constant comparisons of the categories. the results demonstrate that the tutors' use of reflexive strategies such as didactic questioning, didactic empathy and pedagogical silence contributes to encourage the students' reflection and significant learning. reflexive practice is key to tutors' training and students' learning. analisar se o uso de estratégias reflexivas por parte da tutora de estágio clínico estimula a reflexão nos estudantes. A intenção é descobrir qual tipo de estratégias podem ajudar a fazê-lo e como as tutoras e os estudantes se comportam no contexto prático. foi adotado um enfoque qualitativo de cunho etnográfico em que participaram 27 estudantes e 15 tutores de três centros de saúde que haviam recebido formação específica sobre tutoria clínica reflexiva. A análise foi realizada por meio de comparações constantes das categorias. os resultados demonstram que o uso de estratégias reflexivas como a interrogação didática, a empatia didática e o silêncio pedagógico por parte das tutoras, contribui para fomentar a reflexão do estudante e sua aprendizagem significativa. a prática reflexiva é a chave para a formação dos tutores e para a aprendizagem dos estudantes. analizar si el uso de estrategias reflexivas por parte de la tutora de prácticas clínicas fomenta la reflexión en los estudiantes. Se trata de conocer qué tipo de estrategias pueden ayudar a hacerlo y cómo se comportan tutoras y estudiantes en el contexto práctico. se ha utilizado un enfoque cualitativo de corte etnográfico en el que participaron 27 estudiantes y 15 tutores de tres centros sanitarios que habían recibido formación específica sobre tutoría clínica reflexiva. El análisis se ha realizado mediante las comparaciones constantes de las categorías. los resultados demuestran que el uso de estrategias reflexivas como la interrogación didáctica, la empatía didáctica y el silencio pedagógico por parte de las tutoras contribuye a fomentar la reflexión del estudiante y su aprendizaje significativo. la práctica reflexiva es la clave para la formación de los tutores y para el aprendizaje de los estudiantes.

  9. Unit 5, STA. 50+00+RB, Orner Building, First U.M. Church Rectory, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Unit 5, STA. 50+00+RB, Orner Building, First U.M. Church Rectory, & First U.M. Church-context - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

  10. VizieR Online Data Catalog: 24um excesses in clusters & membership of NGC2244 (Meng+, 2017)

    NASA Astrophysics Data System (ADS)

    Meng, H. Y. A.; Rieke, G. H.; Su, K. Y. L.; Gaspar, A.

    2017-09-01

    We re-measured the Spitzer/MIPS 24um photometry for all the clusters except for a few noted in Appendix A. We obtained the 24um data from the Spitzer Heritage Archive between 2004 Jan 28 and 2008 Oct 23. (3 data files).

  11. VizieR Online Data Catalog: X-ray AGNs with Subaru/FMOS NIR observations (Suh+, 2015)

    NASA Astrophysics Data System (ADS)

    Suh, H.; Hasinger, G.; Steinhardt, C.; Silverman, J. D.; Schramm, M.

    2016-03-01

    We performed NIR spectroscopic observations for the AGN sources with the FMOS high-resolution spectrographs on the Subaru telescope; in J-short (0.92-1.12um), J-long (1.11-1.35um), H-short (1.40-1.60um), and H-long (1.60-1.80um) coverage with a spectral resolution of R~2200. The data span the 2012 Mar 25-2013 Oct 24 period. In addition to NIR spectra, we use existing optical spectroscopy (see section 3.2). (2 data files).

  12. VizieR Online Data Catalog: MILO. I. HD 7449 radial velocities (Rodigas+, 2016)

    NASA Astrophysics Data System (ADS)

    Rodigas, T. J.; Arriagada, P.; Faherty, J.; Anglada-Escude, G.; Kaib, N.; Butler, R. P.; Shectman, S.; Weinberger, A.; Males, J. R.; Morzinski, K. M.; Close, L. M.; Hinz, P. M.; Crane, J. D.; Thompson, I.; Teske, J.; Diaz, M.; Minniti, D.; Lopez-Morales, M.; Adams, F. C.; Boss, A. P.

    2016-04-01

    We observed HD 7449 using the Magellan Clay Telescope at the Las Campanas Observatory in Chile on the nights of UT 2014 November 5 and 22. We observed the star with VisAO at Ys (0.99um) and with Clio-2 at H (1.65um) and Ks (2.15um) on the first night and with VisAO at r' (0.63um), i' (0.77um), z' (0.91um), and with Clio-2 at J (1.1um) on the second night. RV data on HD 7449 were first acquired as part of the Magellan Planet Search Program, which originally made use of the MIKE echelle spectrometer (R~70000 in the blue and ~50000 in the red; wavelength coverage ranges from 3900 to 6200Å) on the Magellan Clay telescope until 2009 September. HD 7449 was subsequently observed using the Carnegie Magellan/PFS (3880-6680Å with R~80000 in the iodine region). We also included in our analysis RVs measured with HARPS and CORALIE. These RVs were originally reported in Dumusque et al. (2011, J/A+A/535/A55). HARPS data on HD 7449 has been supplemented by the ESO archive. See section 2.2 for further explanations. (1 data file).

  13. Utility of Serum Creatinine, Creatine Kinase and Urinary Myoglobin in Detecting Acute Renal Failure due to Rhabdomyolysis in Trauma and Electrical Burns Patients.

    PubMed

    Bhavsar, Preetish; Rathod, Kirtikumar Jagdish; Rathod, Darshana; Chamania, C S

    2013-02-01

    Rhabdomyolysis due to trauma and burns is an important cause of acute renal failure (ARF) secondary to myoglobinuria. To prevent morbidity and mortality from ARF due to rhabdomyolysis, early detection of ARF by monitoring the biochemical parameters such as serum creatinine, serum creatine kinase (CK), and urinary myoglobin (UM) can be helpful. The aims of the study were (1) to detect ARF due to rhabdomyolysis using serum creatinine, serum CK, and UM in trauma and electrical burn patients (2) to compare utility of these parameters in early prediction of ARF in patients of rhabdomyolysis. A total of 50 patients with trauma and electrical burns were included in the study. Serum creatinine, serum CK, and UM measurements were done at the time of admission and after 48 h. Diagnosis of ARF was made in the patients by Rifle's criteria. The presence of significant elevation of creatinine, serum CK, and UM at the time of admission and after 48 h was compared in patients developing ARF by Fisher's exact test. Fifteen of the 50 patients developed ARF as per the defined criteria. Of these, 9 patients (60 %) had raised level of serum creatinine above 1.4 mg% at admission and 14 patients (93.33 %) had CK level >1250 U/L at admission, whereas UM was positive in 6 (40 %) patients. Serum creatinine was significantly raised in all of the 15 ARF patients (100 %) after 48 h of admission and serum CK was raised in 14 of the 15 ARF patients (93.33 %). UM was negative in all the patients after 48 h of admission. Statistical analysis showed that rise in serum CK on admission was significantly increased in patients developing ARF as compared with serum creatinine and UM (P < 0.0001). On admission, CK is a better predictor of ARF due to rhabdomyolysis than creatinine and UM. Initial creatinine is a better predictor of ARF due to rhabdomyolysis than UM. UM assay is not a good investigation for early prediction of ARF in rhabdomyolysis.

  14. The commissioning instrument for the Gran Telescopio Canarias: made in Mexico

    NASA Astrophysics Data System (ADS)

    Cuevas, Salvador; Sánchez, Beatriz; Bringas, Vicente; Espejo, Carlos; Flores, Rubén; Chapa, Oscar; Lara, Gerardo; Chavoya, Armando; Anguiano, Gustavo; Arciniega, Sadot; Dorantes, Ariel; Gonzalez, José L.; Montoya, Juan M.; Toral, Rafael; Hernández, Hugo; Nava, Roberto; Devaney, Nicolas; Castro, Javier; Cavaller, Luis; Farah, Alejandro; Godoy, Javier; Cobos, Francisco; Tejada, Carlos; Garfias, Fernando

    2006-02-01

    In March 2004 was accepted in the site of Gran Telescopio Canarias (GTC) in La Palma Island, Spain, the Commissioning Instrument (CI) for the GTC. During the GTC integration phase, the CI will be a diagnostic tool for performance verification. The CI features four operation modes-imaging, pupil imaging, Curvature Wave-front sensing (WFS), and high resolution Shack-Hartmann WFS. This instrument was built by the Instituto de Astronomia UNAM in Mexico City and the Centro de Ingenieria y Desarrollo Industrial (CIDESI) in Queretaro, Qro under a GRANTECAN contract after an international public bid. Some optical components were built by Centro de Investigaciones en Optica (CIO) in Leon Gto and the biggest mechanical parts were manufactured by Vatech in Morelia Mich. In this paper we made a general description of the CI and we relate how this instrument, build under international standards, was entirely made in Mexico.

  15. Foreword: special issue on the geology of Northwestern Mexico and adjacent areas

    NASA Astrophysics Data System (ADS)

    González-León, Carlos M.; Barajas, Arturo Martin

    2001-10-01

    The eight papers presented in this special issue are contributions that were received following the Fourth Meeting on the Geology of Northwestern Mexico and Adjacent Areas that took place from March 6- 8, 2000, in Hermosillo, México. The meeting was organized by the Estación Regional del Noroeste, Instituto de Geología, Universidad Nacional Autónoma de México; Departamento de Geología, Universidad de Sonora; Departamento de Geología, Centro de Investigación Científica y Estudios Superiores de Ensenada; Departamento de Geociencias, Centro de Estudios Superiores del Estado de Sonora; Distrito Sonora, Asociación de Ingenieros de Minas, Metalurgistas y Geólogos de México and Sociedad Geológica Mexicana. The manuscripts present new result that constitute recent advances to our understanding of the geology of southwestern North America.

  16. [Surgical correction of cleft palate].

    PubMed

    Kimura, F T; Pavia Noble, A; Soriano Padilla, F; Soto Miranda, A; Medellín Rodríguez, A

    1990-04-01

    This study presents a statistical review of corrective surgery for cleft palate, based on cases treated at the maxillo-facial surgery units of the Pediatrics Hospital of the Centro Médico Nacional and at Centro Médico La Raza of the National Institute of Social Security of Mexico, over a five-year period. Interdisciplinary management as performed at the Cleft-Palate Clinic, in an integrated approach involving specialists in maxillo-facial surgery, maxillar orthopedics, genetics, social work and mental hygiene, pursuing to reestablish the stomatological and psychological functions of children afflicted by cleft palate, is amply described. The frequency and classification of the various techniques practiced in that service are described, as well as surgical statistics for 188 patients, which include a total of 256 palate surgeries performed from March 1984 to March 1989, applying three different techniques and proposing a combination of them in a single surgical time, in order to avoid complementary surgery.

  17. Comprehending how visual context influences incremental sentence processing: insights from ERPs and picture-sentence verification

    PubMed Central

    Knoeferle, Pia; Urbach, Thomas P.; Kutas, Marta

    2010-01-01

    To re-establish picture-sentence verification – discredited possibly for its over-reliance on post-sentence response time (RT) measures - as a task for situated comprehension, we collected event-related brain potentials (ERPs) as participants read a subject-verb-object sentence, and RTs indicating whether or not the verb matched a previously depicted action. For mismatches (vs matches), speeded RTs were longer, verb N400s over centro-parietal scalp larger, and ERPs to the object noun more negative. RTs (congruence effect) correlated inversely with the centro-parietal verb N400s, and positively with the object ERP congruence effects. Verb N400s, object ERPs, and verbal working memory scores predicted more variance in RT effects (50%) than N400s alone. Thus, (1) verification processing is not all post-sentence; (2) simple priming cannot account for these results; and (3) verification tasks can inform studies of situated comprehension. PMID:20701712

  18. Ga Lithography in Sputtered Niobium for Superconductive Micro and Nanowires.

    DOE PAGES

    Henry, Michael David; Lewis, Rupert M.; Wolfley, Steven L.; ...

    2014-08-18

    This work demonstrates the use of FIB implanted Ga as a lithographic mask for plasma etching of Nb films. Using a highly collimated Ga beam of a FIB, Nb is implanted 12 nm deep with a 14 nm thick Ga layer providing etch selectivity better than 15:1 with fluorine based etch chemistry. Implanted square test patterns, both 10 um by and 10 um and 100 um by 100 um, demonstrate that doses above than 7.5 x 1015 cm-2 at 30 kV provide adequate mask protection for a 205 nm thick, sputtered Nb film. The resolution of this dry lithographic techniquemore » is demonstrated by fabrication of nanowires 75 nm wide by 10 um long connected to 50 um wide contact pads. The residual resistance ratio of patterned Nb films was 3. The superconducting transition temperature, Tc =7.7 K, was measured using MPMS. This nanoscale, dry lithographic technique was extended to sputtered TiN and Ta here and could be used on other fluorine etched superconductors such as NbN, NbSi, and NbTi.« less

  19. Metals in some lagoons of Mexico.

    PubMed Central

    Vazquez, F G; Sharma, V K; Alexander, V H; Frausto, C A

    1995-01-01

    The concentrations of metals, Cd, Cu, Fe, Mn, Ni, Pb, and Zn were determined in some lagoons to establish the level of metal pollution. The lagoons studied were Alvarado lagoon, Veracruz; San Andres lagoon, Tamaulipas; and Terminos lagoon, Campeche. The concentrations were determined in water, oyster (Crassostrea virginica), and sediments. Metals were accumulated in either oysters or sediments. Cu and Zn were higher in oysters and Fe and Mn were higher in sediments. The results in water samples were compared with the limit established by the Secretaria de Ecologia and Desarrollo Urbano Report and briefly discussed. PMID:7621796

  20. VizieR Online Data Catalog: Reflectance spectra of 12 Trojans and Hildas (Marsset+, 2014)

    NASA Astrophysics Data System (ADS)

    Marsset, M.; Vernazza, P.; Gourgeot, F.; Dumas, C.; Birlan, M.; Lamy, P.; Binzel, R. P.

    2014-07-01

    We present 17 reflectance spectra of 12 high albedo (pv>0.14) Trojans (8 objects) and Hildas (4 objects) obtained with the ESO/VLT Echelle spectrograph X-SHOOTER in the 0.3-2.2um spectral range (14 spectra) and with the NASA/IRTF spectrograph SpeX in the 0.8-2.5um spectral range (3 spectra). X-SHOOTER spectra were normalized to unity at 0.55um and SpeX spectra were normalized to unity at 2.2um . The spectra presented in this work were collected between April and December 2013. (18 data files).

  1. The la Plata Astronomical Data Center

    NASA Astrophysics Data System (ADS)

    Marraco, H. G.

    1990-11-01

    RESUMEN. El Centro de Datos Astron6micos tiene su sede en la Facuitad de Ciencias Astron6micas y Geofisicas d la Universidad Nacional de La Plata y funciona por convenio entre esta facultad y el Centre des Stellaires de la Universite' Louis Pasteur en Estrasburgo (CDS), Francia. La finalidad de este centro es la de proveer a los astr6nomos del area con copias de los alrededor de 500 acumulados y/o preparados por el CDS a la vez que promover la producci6n y/o acumulaci6n de en el rea. Para la realizaci6n de esta tarea se cuenta con el apoyo del Centro Superior para el Procesamiento de la Informaci6n (CESPI) de la UNLP cuyos equipos se describen. Las tareas que se estan realizando incluyen la distribuci6n de SIMBAD a los astr6nomos argentinos y se efectuan ensayos de distribuci6n en linea de CD-ROM TEST DISK del Astronomical Data Center (ADC) de la NASA que contiene los 31 mas solicitados por los astr6nomos de todo el mundo. ABSTRACl The La Plata Astronomical Data Center operates by an agreement between the Facultad de Ciencias Astron6micas y Geofisicas at La Plata University and the Centre des Donnees Stellaires of Louis Pasteur University at Strasbourg (CDS), France. The purpose of the Center is to provide to the area astronomers with copies of the catalogs they need amongst those stored and/or prepared at CDS. At the same time the center will act of the astronomical data produced within its area. K words: DATA ANALYSIS

  2. Effects of coarse-graining on the scaling behavior of long-range correlated and anti-correlated signals.

    PubMed

    Xu, Yinlin; Ma, Qianli D Y; Schmitt, Daniel T; Bernaola-Galván, Pedro; Ivanov, Plamen Ch

    2011-11-01

    We investigate how various coarse-graining (signal quantization) methods affect the scaling properties of long-range power-law correlated and anti-correlated signals, quantified by the detrended fluctuation analysis. Specifically, for coarse-graining in the magnitude of a signal, we consider (i) the Floor, (ii) the Symmetry and (iii) the Centro-Symmetry coarse-graining methods. We find that for anti-correlated signals coarse-graining in the magnitude leads to a crossover to random behavior at large scales, and that with increasing the width of the coarse-graining partition interval Δ, this crossover moves to intermediate and small scales. In contrast, the scaling of positively correlated signals is less affected by the coarse-graining, with no observable changes when Δ < 1, while for Δ > 1 a crossover appears at small scales and moves to intermediate and large scales with increasing Δ. For very rough coarse-graining (Δ > 3) based on the Floor and Symmetry methods, the position of the crossover stabilizes, in contrast to the Centro-Symmetry method where the crossover continuously moves across scales and leads to a random behavior at all scales; thus indicating a much stronger effect of the Centro-Symmetry compared to the Floor and the Symmetry method. For coarse-graining in time, where data points are averaged in non-overlapping time windows, we find that the scaling for both anti-correlated and positively correlated signals is practically preserved. The results of our simulations are useful for the correct interpretation of the correlation and scaling properties of symbolic sequences.

  3. Effects of coarse-graining on the scaling behavior of long-range correlated and anti-correlated signals

    PubMed Central

    Xu, Yinlin; Ma, Qianli D.Y.; Schmitt, Daniel T.; Bernaola-Galván, Pedro; Ivanov, Plamen Ch.

    2014-01-01

    We investigate how various coarse-graining (signal quantization) methods affect the scaling properties of long-range power-law correlated and anti-correlated signals, quantified by the detrended fluctuation analysis. Specifically, for coarse-graining in the magnitude of a signal, we consider (i) the Floor, (ii) the Symmetry and (iii) the Centro-Symmetry coarse-graining methods. We find that for anti-correlated signals coarse-graining in the magnitude leads to a crossover to random behavior at large scales, and that with increasing the width of the coarse-graining partition interval Δ, this crossover moves to intermediate and small scales. In contrast, the scaling of positively correlated signals is less affected by the coarse-graining, with no observable changes when Δ < 1, while for Δ > 1 a crossover appears at small scales and moves to intermediate and large scales with increasing Δ. For very rough coarse-graining (Δ > 3) based on the Floor and Symmetry methods, the position of the crossover stabilizes, in contrast to the Centro-Symmetry method where the crossover continuously moves across scales and leads to a random behavior at all scales; thus indicating a much stronger effect of the Centro-Symmetry compared to the Floor and the Symmetry method. For coarse-graining in time, where data points are averaged in non-overlapping time windows, we find that the scaling for both anti-correlated and positively correlated signals is practically preserved. The results of our simulations are useful for the correct interpretation of the correlation and scaling properties of symbolic sequences. PMID:25392599

  4. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells.

    PubMed

    Guarini, Anna; Chiaretti, Sabina; Tavolaro, Simona; Maggio, Roberta; Peragine, Nadia; Citarella, Franca; Ricciardi, Maria Rosaria; Santangelo, Simona; Marinelli, Marilisa; De Propris, Maria Stefania; Messina, Monica; Mauro, Francesca Romana; Del Giudice, Ilaria; Foà, Robert

    2008-08-01

    Chronic lymphocytic leukemia (CLL) patients exhibit a variable clinical course. To investigate the association between clinicobiologic features and responsiveness of CLL cells to anti-IgM stimulation, we evaluated gene expression changes and modifications in cell-cycle distribution, proliferation, and apoptosis of IgV(H) mutated (M) and unmutated (UM) samples upon BCR cross-linking. Unsupervised analysis highlighted a different response profile to BCR stimulation between UM and M samples. Supervised analysis identified several genes modulated exclusively in the UM cases upon BCR cross-linking. Functional gene groups, including signal transduction, transcription, cell-cycle regulation, and cytoskeleton organization, were up-regulated upon stimulation in UM cases. Cell-cycle and proliferation analyses confirmed that IgM cross-linking induced a significant progression into the G(1) phase and a moderate increase of proliferative activity exclusively in UM patients. Moreover, we observed only a small reduction in the percentage of subG(0/1) cells, without changes in apoptosis, in UM cases; contrariwise, a significant increase of apoptotic levels was observed in stimulated cells from M cases. These results document that a differential genotypic and functional response to BCR ligation between IgV(H) M and UM cases is operational in CLL, indicating that response to antigenic stimulation plays a pivotal role in disease progression.

  5. Calibração do sistema imageador do telescópio MASCO

    NASA Astrophysics Data System (ADS)

    Mejía, J.; D'Amico, F.; Villela, T.; Braga, J.

    2003-08-01

    O MASCO (MÁScara COdificada) é um telescópio imageador de raios-X e gama atualmente configurado para operar na faixa de 50 a 600 keV com uma resolução angular de 14 minutos de arco num campo de visada total circular de 23,5° de diâmetro. O MASCO está totalmente operacional e deverá ser lançado em um balão estratosférico no segundo semestre de 2003 para realizar observações durante ~20 horas a ~40 km de altitude. O telescópio utiliza uma máscara codificada de padrão uniformemente redundante modificado (MURA) de dimensões 19 ´ 19. Esse padrão pertence a uma subclasse de MURAs que apresenta anti-simetria de 90° e conseqüentemente permite a utilização da técnica de subtração de variações sistemáticas de ruído de fundo através de utilização da configuração anti-máscara, obtida com uma simples rotação da máscara. Neste trabalho apresentamos resultados de calibrações em laboratório que tiveram como objetivo testar o sistema imageador. Imagens de fontes radioativas foram obtidas com o telescópio em configuração de vôo, com a máscara girando. Serão discutidos os resultados desses testes e as técnicas desenvolvidas para eliminar ambigüidades de posição de fontes, otimização da relação sinal-ruído e observação de fontes fora do campo totalmente codificado. O sistema de máscara/antimáscara mostrou-se capaz de aumentar a relação sinal-ruído de ~60% para fontes intensas (100 s). Com a máscara girando, a técnica de reconstrução de imagens desenvolvida identificou a posição exata da fonte e não introduziu perda de sensibilidade. Imagens de uma fonte colocada a 8,3° - fora do campo totalmente codificado do telescópio -, mostraram uma diminuição de ~40% na relação sinal/ruído em relação ao centro do campo de visada, o que se deve à codificação incompleta pela máscara e à absorção parcial do fluxo pelos detectores de blindagem.

  6. "Uh" and "Um" Revisited: Are They Interjections for Signaling Delay?

    ERIC Educational Resources Information Center

    O'Connell, Daniel C.; Kowal, Sabine

    2005-01-01

    Clark and Fox Tree (2002) have presented empirical evidence, based primarily on the London-Lund corpus (LL; Svartvik & Quirk, 1980), that the fillers "uh" and "um" are conventional English words that signal a speaker's intention to initiate a minor and a major delay, respectively. We present here empirical analyses of "uh" and "um" and of silent…

  7. The attitudes, role & knowledge of mental health nurses towards euthanasia because of unbearable mental suffering in Belgium: a pilot study.

    PubMed

    Demedts, Dennis; Roelands, Marc; Libbrecht, Julien; Bilsen, Johan

    2018-05-26

    Euthanasia because of unbearable mental suffering (UMS euthanasia) has been legal in Belgium since 2002, under certain circumstances that govern careful practice. Despite the legal framework, there are specific difficulties and concerns regarding UMS euthanasia. Mental health nurses are often involved in the process, but little is known about their attitudes towards UMS euthanasia, their role and their knowledge. To determine the attitudes, role and knowledge of mental health nurses regarding UMS euthanasia. A cross-sectional survey was performed at a convenience sample of four psychiatric hospitals in Belgium (n=133) as a pilot study. Self-administered questionnaires were provided to mental health nurses. Half the nurses in our sample had been involved at least once in the process of UMS euthanasia. A large majority of mental health nurses were supportive of UMS euthanasia. Nurses show differences in attitudes related to the different psychiatric pathologies of the patients, and in whether or not minors are involved. In some cases, they believed that the mental suffering of psychiatric patients can be unbearable and irreversible and that psychiatric patients can be competent to voluntarily request UMS euthanasia. Nurses stated that they have an important role in the UMS euthanasia process, but also demanded more knowledge and clear guidelines to implement the procedure. Nurses have a key role regarding UMS euthanasia but face several challenges: the recent process, resistance to a multidisciplinary approach by psychiatrists and an unclear role defined by the legal framework. Nurses do not appear to have a common voice on the topic and the development of clear guidelines appears to be essential. Social recovery can offer a way out of an UMS euthanasia request, but it will not always offer a solution. Sufficient attention must be paid to how mental health nurses can be involved in the process of UMS euthanasia at various levels: bedside practice, healthcare management, education and policy. A form of systematic cooperation between nurses, physicians and patients can contribute to the utmost careful decision-making process needed in these cases. There is a need for proper training in: knowledge of psychiatric pathologies and remaining treatment options; communication skills; the legal framework and all its difficulties; transdisciplinary and multicultural approaches; ethical reflection and how nurses handle their own emotions. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  8. The short form of the recombinant CAL-A-type lipase UM03410 from the smut fungus Ustilago maydis exhibits an inherent trans-fatty acid selectivity.

    PubMed

    Brundiek, Henrike; Saß, Stefan; Evitt, Andrew; Kourist, Robert; Bornscheuer, Uwe T

    2012-04-01

    The Ustilago maydis lipase UM03410 belongs to the mostly unexplored Candida antarctica lipase (CAL-A) subfamily. The two lipases with [corrected] the highest identity are a lipase from Sporisorium reilianum and the prototypic CAL-A. In contrast to the other CAL-A-type lipases, this hypothetical U. maydis lipase is annotated to possess a prolonged N-terminus of unknown function. Here, we show for the first time the recombinant expression of two versions of lipase UM03410: the full-length form (lipUMf) and an Nterminally truncated form (lipUMs). For comparison to the prototype, the expression of recombinant CAL-A in E. coli was investigated. Although both forms of lipase UM03410 could be expressed functionally in E. coli, the N-terminally truncated form (lipUMs) demonstrated significantly higher activities towards p-nitrophenyl esters. The functional expression of the N-terminally truncated lipase was further optimized by the appropriate choice of the E. coli strain, lowering the cultivation temperature to 20 °C and enrichment of the cultivation medium with glucose. Primary characteristics of the recombinant lipase are its pH optimum in the range of 6.5-7.0 and its temperature optimum at 55 °C. As is typical for lipases, lipUM03410 shows preference for long chain fatty acid esters with myristic acid ester (C14:0 ester) being the most preferred one.More importantly, lipUMs exhibits an inherent preference for C18:1Δ9 trans and C18:1Δ11 trans-fatty acid esters similar to CAL-A. Therefore, the short form of this U. maydis lipase is the only other currently known lipase with a distinct trans-fatty acid selectivity.

  9. Uh and um revisited: are they interjections for signaling delay?

    PubMed

    O'Connell, Daniel C; Kowal, Sabine

    2005-11-01

    Clark and Fox Tree (2002) have presented empirical evidence, based primarily on the London-Lund corpus (LL; Svartvik & Quirk, 1980), that the fillers uh and um are conventional English words that signal a speaker's intention to initiate a minor and a major delay, respectively. We present here empirical analyses of uh and um and of silent pauses (delays) immediately following them in six media interviews of Hillary Clinton. Our evidence indicates that uh and um cannot serve as signals of upcoming delay, let alone signal it differentially: In most cases, both uh and um were not followed by a silent pause, that is, there was no delay at all; the silent pauses that did occur after um were too short to be counted as major delays; finally, the distributions of durations of silent pauses after uh and um were almost entirely overlapping and could therefore not have served as reliable predictors for a listener. The discrepancies between Clark and Fox Tree's findings and ours are largely a consequence of the fact that their LL analyses reflect the perceptions of professional coders, whereas our data were analyzed by means of acoustic measurements with the PRAAT software (www.praat.org). A comparison of our findings with those of O'Connell, Kowal, and Ageneau (2005) did not corroborate the hypothesis of Clark and Fox Tree that uh and um are interjections: Fillers occurred typically in initial, interjections in medial positions; fillers did not constitute an integral turn by themselves, whereas interjections did; fillers never initiated cited speech, whereas interjections did; and fillers did not signal emotion, whereas interjections did. Clark and Fox Tree's analyses were embedded within a theory of ideal delivery that we find inappropriate for the explication of these phenomena.

  10. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial.

    PubMed

    González-Sarrías, Antonio; García-Villalba, Rocío; Romo-Vaquero, María; Alasalvar, Cesarettin; Örem, Asim; Zafrilla, Pilar; Tomás-Barberán, Francisco A; Selma, María V; Espín, Juan Carlos

    2017-05-01

    The pomegranate lipid-lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism. We aimed at investigating whether the microbially derived ellagitannin-metabolizing phenotypes, i.e. urolithin metabotypes A, (UM-A), B (UM-B), and 0 (UM-0), influence the effects of pomegranate extract (PE) consumption on 18 cardiovascular risk biomarkers in healthy overweight-obese individuals. A double-blind, crossover, dose-response, randomized, placebo-controlled trial was conducted. The study (POMEcardio) consisted of two test phases (dose-1 and dose-2, lasting 3 weeks each) and a 3-week washout period between each phase. Forty-nine participants (BMI > 27 kg/m 2 ) daily consumed one (dose-1, 160 mg phenolics/day) or four (dose-2, 640 mg phenolics/day) PE or placebo capsules. Notably, UM-B individuals showed the highest baseline cardiovascular risk. After dose-2, total cholesterol (-15.5 ± 3.7%), LDL-cholesterol (-14.9 ± 2.1%), small LDL-cholesterol (-47 ± 7%), non-HDL-cholesterol (-11.3 ± 2.5%), apolipoprotein-B (-12 ± 2.2%), and oxidized LDL-cholesterol -24 ± 2.5%) dose dependently decreased (P < 0.05) but only in UM-B subjects. These effects were partially correlated with urolithin production and the increase in Gordonibacter levels. Three (50%) nonproducers (UM-0) became producers following PE consumption. UM clustering suggests a personalized effect of ellagitannin-containing foods and could explain the controversial pomegranate benefits. Research on the specific role of urolithins and the microbiota associated with each UM is warranted. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Medical condition and care of undocumented migrants in ambulatory clinics in Tel Aviv, Israel: assessing unmet needs.

    PubMed

    Mor, Zohar; Raveh, Yuval; Lurie, Ido; Leventhal, Alex; Gamzu, Roni; Davidovitch, Nadav; Benari, Orel; Grotto, Itamar

    2017-07-14

    Approximately 150,000 undocumented migrants (UM) who are medically uninsured reside in Israel, including ~50,000 originating from the horn of Africa (MHA). Free medical-care is provided by two walk-in clinics in Tel-Aviv. This study aims to compare the medical complaints of UM from different origins, define their community health needs and assess gaps between medical needs and available services. This cross-sectional study included a random sample of 610 UM aged 18-64 years, who were treated in these community clinics between 2008 and 2011. The study compared UM who had complex medical conditions which necessitated referral to more equipped medical settings with UM having mild/simple medical conditions, who were treated at the clinics. MHA were younger, unemployed and more commonly males compared with UM originating from other countries. MHA also had longer referral-delays and visited the clinics less frequently. UM with complex medical conditions were more commonly females, had chronic diseases and demonstrated longer referral-delays than those who had mild/simple medical conditions. The latter more commonly presented with complained of respiratory, muscular and skeletal discomfort. In multivariate analysis, the variables which predicted complex medical conditions included female gender, chronic illnes and self-referral to the clinics. The ambulatory clinics were capable of responding to mild/simple medical conditions. Yet, the health needs of women and migrants suffering from complex medical conditions and chronic diseases necessitated referrals to secondary/tertiary medical settings, while jeopardizing the continuity of care. The health gaps can be addressed by a more holistic social approach, which includes integration of UM in universal health insurance.

  12. High-speed, large-area, p-i-n InGaAs photodiode linear array at 2-micron wavelength

    NASA Astrophysics Data System (ADS)

    Joshi, Abhay; Datta, Shubhashish

    2012-06-01

    We present 16-element and 32-element lattice-mismatched InGaAs photodiode arrays having a cut-off wavelength of ~2.2 um. Each 100 um × 200 um large pixel of the 32-element array has a capacitance of 2.5 pF at 5 V reverse bias, thereby allowing a RC-limited bandwidth of ~1.3 GHz. At room temperature, each pixel demonstrates a dark current of 25 uA at 5 V reverse bias. Corresponding results for the 16-element array having 200 um × 200 um pixels are also reported. Cooling the photodiode array to 150K is expected to reduce its dark current to < 50 nA per pixel at 5 V reverse bias. Additionally, measurement results of 2-micron single photodiodes having 16 GHz bandwidth and corresponding PIN-TIA photoreceiver having 6 GHz bandwidth are also reported.

  13. Development of a non-contextual model for determining the autonomy level of intelligent unmanned systems

    NASA Astrophysics Data System (ADS)

    Durst, Phillip J.; Gray, Wendell; Trentini, Michael

    2013-05-01

    A simple, quantitative measure for encapsulating the autonomous capabilities of unmanned systems (UMS) has yet to be established. Current models for measuring a UMS's autonomy level require extensive, operational level testing, and provide a means for assessing the autonomy level for a specific mission/task and operational environment. A more elegant technique for quantifying autonomy using component level testing of the robot platform alone, outside of mission and environment contexts, is desirable. Using a high level framework for UMS architectures, such a model for determining a level of autonomy has been developed. The model uses a combination of developmental and component level testing for each aspect of the UMS architecture to define a non-contextual autonomous potential (NCAP). The NCAP provides an autonomy level, ranging from fully non- autonomous to fully autonomous, in the form of a single numeric parameter describing the UMS's performance capabilities when operating at that level of autonomy.

  14. REDUCTIVE DEHALOGENATION OF HEXACHLOROETHANE, CARBON TETRACHLORIDE, AND BROMOFORM BY ANAHYDROQUINONE DISULFONATE AND HUMIC ACID

    EPA Science Inventory

    The reductive dehalogenation of hexachloroethane (C2CI6), carbon tetrachloride (CC14), and bromoform (CHBr3) was examined at 50 degrees C in aqueous solutions containing either (1) 500 uM of 2,6-anthrahydroquinone disulfonate (AHQDS), (2) 250 uM Fe2+, or (3) 250 uM HS. The pH ran...

  15. Assessment of Teams and Teamwork in the University of Maryland Libraries

    ERIC Educational Resources Information Center

    Baughman, M. Sue

    2008-01-01

    Teams play an important role in the University of Maryland (UM) Libraries. Since 1998, teams and collaborative teamwork have become the way librarians address the myriad of issues affecting the needs of UM's faculty, students, and staff. There has been much change in the UM Libraries over the past nine years, and the development is ongoing.…

  16. Somatic embryogenesis in immature cotyledons of Manchurian ash (Fraxinus mandshurica Rupr.)

    USDA-ARS?s Scientific Manuscript database

    Somatic embryogenesis was obtained from immature cotyledon explants that were cultured on half-strength Murashige and Skoog (MS) salts and vitamins with 5.4 uM naphthaleneacetic acid (NAA) and 0.2 uM thidiazuron (TDZ) plus a 4x4 factorial combination of 0,9.8, 34.6, or 49.2 uM indole-3-butyric acid ...

  17. VizieR Online Data Catalog: Young clumps embedded in IRDC (Traficante+, 2015)

    NASA Astrophysics Data System (ADS)

    Traficante, A.; Fuller, G. A.; Peretto, N.; Pineda, J. E.; Molinari, S.

    2015-06-01

    Photometric parameters for 667 starless clumps (sources identified at 160um with a counterpart at 250 and 350um) and 1056 protostellar clumps (sources identified at 160um with a counterpart at 70, 250 and 350um). Photometric parameters obtained with Hyper photometry code (2015A&A...574A.119T). The photometry is corrected for aperture and colour corrections. The parameter list is the standard Hyper output (see description below). SED fit parameters for 650 starless clumps and 1034 protostellar clumps (all clumps with good SED fitting: Chi2<10, Temperature<40K. See the paper for details) (4 data files).

  18. VizieR Online Data Catalog: Draco nebula Herschel 250um map (Miville-Deschenes+, 2017)

    NASA Astrophysics Data System (ADS)

    Miville-Deschenes, M.-A.; Salome, Q.; Martin, P. G.; Joncas, G.; Blagrave, K.; Dassas, K.; Abergel, A.; Beelen, A.; Boulanger, F.; Lagache, G.; Lockman, F. J.; Marshall, D. J.

    2017-03-01

    Draco was observed with Herschel PACS (110 and 170um) and SPIRE (250, 350 and 500um) as part of the open-time program "First steps toward star formation: unveiling the atomic to molecular transition in the diffuse interstellar medium" (P.I. M-A Miville-Deschenes). A field of 3.85x3.85 was observed in parallel mode. Unfortunately, an error occurred during the acquisition of the PACS data making them unusable. Therefore, the results presented here are solely based on SPIRE data, especially the 250um map that has the highest angular resolution. (2 data files).

  19. High Frequency GaAs Bulk Acousto-Optic Devices For Modulators And Frequency Shifters At 1.3um And 1.5um In Fiber-Optics

    NASA Astrophysics Data System (ADS)

    Soos, J. I.; Rosemeier, R. G.

    1989-02-01

    The edge of a transmission window for a GaAs Bragg cell starts about lum, which allows this material to be used for infrared fiber-optic applications, especially at 1.3um and 1.5um. The single crystal of GaAs is acoustically anisotropic and has the highest figure of merit, M2, along <111> direction for a longitudinal mode sound wave. Recently, Brimrose has designed and fabricated an acousto-optic modulator from GaAs operating at a carrier frequency of 2.3 GHz with a diffraction efficiency of 4%/RF watt.

  20. VizieR Online Data Catalog: LRLL54361 protostar Herschel/PACS fluxes (Balog+, 2014)

    NASA Astrophysics Data System (ADS)

    Balog, Z.; Muzerolle, J.; Flaherty, K.; Detre, O. H.; Bouwmann, J.; Furlan, E.; Gutermuth, R.; Juhasz, A.; Bally, J.; Nielbock, M.; Klaas, U.; Krause, O.; Henning, T.; Marton, G.

    2017-03-01

    We observed a 14'x14' area in IC348 with the Photodetector Array Camera and Spectrometer (PACS; Poglitsch et al. 2010A&A...518L...2P) Herschel Space Observatory (Pilbratt et al. 2010A&A...518L...1P) simultaneously at 70 and 160um 24 times in scan map mode. An additional five epoch were observed during a later pulse phase of LRLL54361 in all three PACS photometer bands. The PACS spectrograph consists of a 5x5 array of 9.4" x 9.4" spatial pixels (hereafter referred to as spaxels) covering the spectral range from 52-210 um with λ/δλ ~1000-3000. Spectra were obtained in two spectral orders simultaneously, with the second order ranging from 51 to 105um and the first order from 102 to 210um. The spatial resolution of PACS-S ranges from ~9'' at 50um to ~18'' at 210um. Our target was observed in the standard range-scan spectroscopy mode with a grating step size corresponding to Nyquist sampling (see further Poglitsch et al. 2010A&A...518L...2P). (1 data file).

  1. [Estimation of uncertainty of measurement in clinical biochemistry].

    PubMed

    Enea, Maria; Hristodorescu, Cristina; Schiriac, Corina; Morariu, Dana; Mutiu, Tr; Dumitriu, Irina; Gurzu, B

    2009-01-01

    The uncertainty of measurement (UM) or measurement uncertainty is known as the parameter associated with the result of a measurement. Repeated measurements usually reveal slightly different results for the same analyte, sometimes a little higher, sometimes a little lower, because the results of a measurement are depending not only by the analyte itself, but also, by a number of error factors that could give doubts about the estimate. The uncertainty of the measurement represent the quantitative, mathematically expression of this doubt. UM is a range of measured values which is probably to enclose the true value of the measured. Calculation of UM for all types of laboratories is regularized by the ISO Guide to the Expression of Uncertainty in Measurement (abbreviated GUM) and the SR ENV 13005 : 2003 (both recognized by European Accreditation). Even if the GUM rules about UM estimation are very strictly, the offering of the result together with UM will increase the confidence of customers (patients or physicians). In this study the authors are presenting the possibilities of UM assessing in labs from our country by using the data obtained in the procedures of methods validation, during the internal and external quality control.

  2. VizieR Online Data Catalog: Spectrophotometric distances of HII regions (Moises+, 2011)

    NASA Astrophysics Data System (ADS)

    Moises, A. P.; Damineli, A.; Figueredo, E.; Blum, R. D.; Conti, P. S.; Barbosa, C. L.

    2011-11-01

    The J-band (λ1.28um, δλ=0.3um), H-band (λ1.63um, δλ=0.3um) and Ks-band (λ2.19um, δλ=0.4um) images were obtained on the nights of 1999 May 1, 4 and 20, 2000 May 19 and 21 and 2001 July 10 and 12, at the Cerro Tololo Inter-American Observatory (CTIO) 4-m Blanco telescope, using the facility's infrared imager OSIRIS, which has a field of view (FOV) of 93x93arcsec2 and a pixel scale of 0.161arcsec/pixel. On the nights of 2005 Jult 3-6 and 11 and 2006 June 3-7, we obtained images using the facility's infrared imager ISPI (with a FOV of 10.25x10.25arcmin2 and a pixel scale of 0.3arcsec/pix), also at the 4-m Blanco telescope. Also, on the nights of 1998 August 28 and 29, we obtained images on the CTIO 4-m telescope using the facility's infrared imager CIRIM (with a FOV of 102x102arcsec2 and a pixel scale of 0.40arcsec/pix). (3 data files).

  3. Unconsummated marriage: can it still be considered a consequence of vaginismus?

    PubMed

    Michetti, P M; Silvaggi, M; Fabrizi, A; Tartaglia, N; Rossi, R; Simonelli, C

    2014-01-01

    Unconsummated marriage (UM) is the failure to perform successful sexual intercourse at the beginning of the marriage. Vaginismus has been traditionally reported as the leading cause. ED is also a leading cause for UM. This appears to be a significant problem in the conservative middle-Eastern societies and in the developing countries, where couples are strongly prevented by religious rules and cultural taboos from sexual experiences before wedding. One could think that according to major sexual freedom and information, in Western countries UM is now disappearing, but the number of observed cases by the authors in 2008-2012 was relevant. The aim of this study is to compare the literature data from non-Western countries with the features of UM in Western ones, focusing on cases observed by the authors, and to verify whether the etiology of UM proposed in the '70s is still relevant, outlining any changes that occur in current reality. In our series, traditional appearance of UM is no more effective, while the role of man is undervalued, because of his frailty, lack of self-confidence and ignorance, expressing a social and cultural change of man's role in the couple.

  4. Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.

    PubMed

    Yan, Fengxia; Liao, Rifang; Farhan, Mohd; Wang, Tinghuai; Chen, Jiashu; Wang, Zhong; Little, Peter J; Zheng, Wenhua

    2016-12-01

    Uveal melanoma (UM) is the most common primary intraocular malignant tumor of adults. It has high mortality rate due to liver metastasis. However, the epidemiology and pathogenesis of liver metastasis in UM are not elucidated and there is no effective therapy available for preventing the development of this disease. IGF-1 is a growth factor involved in cell proliferation, malignant transformation and inhibition of apoptosis. In previous report, IGF-1 receptor was found to be highly expressed in UM and this was related to tumor prognosis. FoxO3a is a Forkhead box O (FOXO) transcription factor and a downstream target of the IGF-1R/PI3K/Akt pathway involved in a number of physiological and pathological processes including cancer. However, the role of FoxO3a in UM is unknown. In the present study, we investigated fundamental mechanisms in the growth, migration and invasion of UM and the involvement of FoxO3a. IGF-1 increased the cell viability, invasion, migration and S-G2/M cell cycle phase accumulation of UM cells. Western blot analysis showed that IGF-1 led to activation of Akt and concomitant phosphorylation of FoxO3a. FoxO3a phosphorylation was associated with its translocation into the cytoplasm from the nucleus and its functional inhibition led to the inhibition of expression of Bim and p27, but an increase in the expression of Cyclin D1. The effects of IGF-1 on UM cells were reversed by LY294002 (a PI3K inhibitor) or Akt siRNA, and the overexpression of FoxO3a also attenuated basal invasion and migration of UM. Taken all together, these results suggest that inhibition of FoxO3a by IGF-1 via the PI3K/Akt pathway has an important role in IGF-1 induced proliferation and invasion of UM cells. These findings also support FoxO3a and IGF signaling may represent a valid target for investigating the development of new strategies for the treatment and prevention of the pathology of UM. Copyright © 2016. Published by Elsevier Masson SAS.

  5. From Self-Organized to Extended Criticality

    DTIC Science & Technology

    2012-04-26

    Texas, Denton, TX, USA 2 Centro EXTREME, Scuola Superiore Sant’Anna, Pisa, Italy 3 Istituto di Fisiologia Clinica-CNR, Pisa, Italy 4 Department of Physics...Netherlands Klaus Linkenkaer-Hansen, Center for Neurogenomics and Cognitive Research, Netherlands *Correspondence: Paolo Allegrini , Istituto di Fisiologia

  6. [The psychoanalytic interview of slum dwellers in Lima].

    PubMed

    Rodríguez Rabanal, C

    1990-07-01

    A large, as yet unfinished project conducted by the "Centro Psicoanálisis y Sociedad" concerns the use of psychoanalytic methods in social research. Case excerpts are presented to illustrate typical forms of the subjective processing of migration and marginalization.

  7. Undermethylated DNA as a source of microsatellites from a conifer genome.

    PubMed

    Zhou, Y; Bui, T; Auckland, L D; Williams, C G

    2002-02-01

    Developing microsatellites from the large, highly duplicated conifer genome requires special tools. To improve the efficiency of developing Pinus taeda L. microsatellites, undermethylated (UM) DNA fragments were used to construct a microsatellite-enriched copy library. A methylation-sensitive restriction enzyme, McrBC, was used to enrich for UM DNA before library construction. Digested DNA fragments larger than 9 kb were then excised and digested with RsaI and used to construct nine dinucleotide and trinucleotide libraries. A total of 1016 microsatellite-positive clones were detected among 11 904 clones and 620 of these were unique. Of 245 primer sets that produced a PCR product, 113 could be developed as UM microsatellite markers and 70 were polymorphic. Inheritance and marker informativeness were tested for a random sample of 36 polymorphic markers using a three-generation outbred pedigree. Thirty-one microsatellites (86%) had single-locus inheritance despite the highly duplicated nature of the P. taeda genome. Nineteen UM microsatellites had highly informative intercross mating type configurations. Allele number and frequency were estimated for eleven UM microsatellites using a population survey. Allele numbers for these UM microsatellites ranged from 3 to 12 with an average of 5.7 alleles/locus. Frequencies for the 63 alleles were mostly in the low-common range; only 14 of the 63 were in the rare allele (q < 0.05) class. Enriching for UM DNA was an efficient method for developing polymorphic microsatellites from a large plant genome.

  8. VizieR Online Data Catalog: UKIDSS-DR8 LAS, GCS and DXS Surveys (Lawrence+ 2012)

    NASA Astrophysics Data System (ADS)

    Lawrence, A.; Warren, S. J.; Almaini, O.; Edge, A. C.; Hambly, N. C.; Jameson, R. F.; Lucas, P.; Casali, M.; Adamson, A.; Dye, S.; Emerson, J. P.; Foucaud, S.; Hewett, P.; Hirst, P.; Hodgkin, S. T.; Irwin, M. J.; Lodieu, N.; McMahon, R. G.; Simpson, C.; Smail, I.; Mortlock, D.; Folger, M.

    2012-03-01

    The UKIRT Infrared Deep Sky Survey (UKIDSS) is a large-scale near-IR survey which aim is to cover 7500 square degrees of the Northern sky. The survey is carried out using the Wide Field Camera (WFCAM), with a field of view of 0.21 square degrees, mounted on the 3.8m United Kingdom Infra-red Telescope (UKIRT) in Hawaii. The project comprises five surveys (LAS, GCS, DXS, GPS and UDS). The Large Area Survey (LAS) covers an area of 4000 square degrees in high Galactic latitudes (extragalactic) in the four bands Y(1.0um) J(1.2um) H(1.6um) and K(2.2um) to a depth of K=18.4. The Galactic Clusters Survey (GCS) aims to survey ten large open star clusters and star formation associations, covering a total of 1067 square degrees in the five bands Z (0.9um), Y(1.0um) J(1.2um) H(1.6um) and K(2.2um), plus a second pass in K for proper motions, to a depth of Z=20.4, Y=20.3, J=19.5, H=18.6, K=18.6. The Deep Extragalactic Survey (DXS) aims to map 35 square degrees of sky to a 5-σ point-source sensitivity of J=22.3 and K=20.8 in four carefully selected, multi-wavelength survey areas. The central regions of each field will also be mapped to H=21.8. The primary aim of the survey is to produce a photometric galaxy sample at a redshift of 1-2, within a volume comparable to that of the SDSS, selected in the same passband (rest frame optical). Details of the surveys can be found in the in the paper by Lawrence et al. (2007MNRAS.379.1599L), and at the UKIDSS Surveys site (http://www.ukidss.org/surveys/surveys.html). The data described here represent a subset of the UKIDSS data, limited to the public data and most representative columns. In the "Byte-by-byte Description" below the original names of the columns are given as bracketed names. (3 data files).

  9. PREFACE: Acknowledgements

    NASA Astrophysics Data System (ADS)

    2015-06-01

    The organizers of the conference would like to thank for the support from the Physics Department and the Offce of Academic Affairs of the Centro de Investigación y de Estudios Avanzados and from the Consejo Nacional de Ciencia y Tecnología (Conacyt), projects 152574 and 166581.

  10. Study on extrusion process of SiC ceramic matrix

    NASA Astrophysics Data System (ADS)

    Dai, Xiao-Yuan; Shen, Fan; Ji, Jia-You; Wang, Shu-Ling; Xu, Man

    2017-11-01

    In this thesis, the extrusion process of SiC ceramic matrix has been systematically studied.The effect of different cellulose content on the flexural strength and pore size distribution of SiC matrix was discussed.Reselts show that with the increase of cellulose content, the flexural strength decreased.The pore size distribution in the sample was 1um-4um, and the 1um-2um concentration was more concentrated. It is found that the cellulose content has little effect on the pore size distribution.When the cellulose content is 7%, the flexural strength of the sample is 40.9Mpa. At this time, the mechanical properties of the sample are the strongest.

  11. Study and optimization of the macroscopic electrical response of carbon based nanocomposites for advanced applications

    NASA Astrophysics Data System (ADS)

    Silva, Jaime Pedro Oliveira da

    A presente tese centrou-se no estudo da resposta da constante dieletrica e condutividade eletrica em materiais compositos nos quais o reforco tinha uma elevada proporcao entre comprimento e diametro. O objeto de estudo foi o efeito de um reforco com uma elevada razao entre comprimento e diametro, concentracao e orientacao na resposta eletrica e dieletrica de um composito. Estes compositos tem uma grande importancia no desenvolvimento de materiais para sensores e atuadores. Num primeiro momento da dissertacao, explorou-se a resposta da constante dieletrica de um composito constituido por nanotubos de carbono como reforco e uma matriz polimerica. Verificou-se que um aumento da razao entre comprimento e diametro do reforco tem o efeito de aumentar a constante dieletrica do composito para uma igual fracao volumetrica de reforco. Constatou-se tambem que materiais na fase nematica demonstram uma constante dieletrica mais baixa quando comparados com materiais onde o reforco esta distribuido aleatoriamente. Ficou ainda demonstrado nesta dissertacao que materiais na fase nematica com razoes entre o comprimento e diametro diferentes a constante dieletrica segue uma lei de potencia. Numa segunda fase do trabalho, foi explorada a condutividade de nanocompositos polimericos reforcados com nanotubos de carbono, atraves de um modelo baseado em cilindros impenetraveis. Ficou demonstrado que o modelo e apropriado para descrever a condutividade eletrica de um nanocomposito polimerico reforcado com nanotubos. As simulacoes desenvolvidas demonstram que, aumentando a razao entre o comprimento e o diametro dos nanotubos de carbono, aumenta a condutividade eletrica do nanocomposito. No entanto, verifica-se que aumentando a anisotropia diminui a condutividade, sendo este efeito mais evidente para fracoes volumetricas maiores. Nesta dissertacao comprovou-se ainda que uma microestrutura gerada por um algoritmo de empacotamento sequencial pode ser descrita por um grafo aleatorio e que a condutividade num composito reforcado com nanofibras de carbono pode ser descrito por uma rede de Bethe. Atraves do uso da teoria das redes complexas, chegou-se a uma expressao para o limite de percolacao e, do mesmo modo, demonstrou-se que “hopping” entre fibras adjacentes resulta numa expressao que corresponde a um regime de desordem fraca. No trabalho desenvolvido tambem foi calculado os expoentes criticos, atraves da teoria das redes, para um sistema 3D composto por cilindros impenetraveis com uma interacao de curto alcance, demonstrando que os expoentes criticos estao relacionados por uma relacao de hiperescala comum para 3D e nao pertencem a mesma classe de universalidade como a percolacao numa rede. A aplicacao do modelo desenvolvido a compositos de epoxy reforcada, com diferentes metodos de dispersao de nanofibras de carbono, revelou que os metodos de dispersao usados para preparar os compositos tem uma forte influencia nas propriedades eletricas que podem ser capturadas pelo modelo. Neste contexto, ficou ainda demonstrado que a condutividade eletrica pode ser descrita por um regime de desordem fraca, isto ´e, um regime onde todas as conexoes fibra-fibra participam na condutividade do composito. O modelo desenvolvido foi aplicado igualmente a compositos de poly (vinylidene fluoride) reforcado com nanotubos de carbono com diferentes tratamentos de termicos de oxidacao. Verificou-se que os tratamentos de superficie aumentam o limite de percolacao e diminuem a condutividade. Nesta dissertacao provamos ainda que a condutividade do composito pode ser atribuida a um mecanismo de “hopping”, fortemente afetado pelos tratamentos de superficie dos reforcos.

  12. Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by triazolobenzodiazepines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Obata, T.; Yamamura, H.I.

    1988-01-01

    The effects of triazolobenzodiazepines of GABA-stimulated /sup 36/Cl/sup -/ uptake by membrane vesicles from rat cerebral cortex were examined. Triazolam and alprazolam showed a significant enhancement of GABA-stimulated /sup 36/Cl/sup -/ uptake at 0.01-10 uM. On the other hand, adinazolam showed a small enhancement at 0.1-1 uM followed by a significant inhibition of GABA-stimulated /sup 36/Cl/sup -/ uptake at 100 uM. The enhancement of GABA-stimulated /sup 36/Cl/sup -/ uptake by 1 uM alprazolam was antagonized by Ro15-1788, a benzodiazepine antagonist, but the inhibition of this response by 30 uM adinazolam was not antagonized by Ro15-1788. These results indicate that triazolobenzodiazepinesmore » enhanced GABA-stimulated /sup 36/Cl/sup -/ uptake through benzodiazepine receptors. High concentrations of adinazolam inhibit GABA-stimulated /sup 36/Cl/sup -/ uptake which may be due to the direct blockade of GABA-gated chloride channel. 23 references, 4 figures.« less

  13. Selumetinib-based therapy in uveal melanoma patient-derived xenografts

    PubMed Central

    Decaudin, Didier; El Botty, Rania; Diallo, Béré; Massonnet, Gerald; Fleury, Justine; Naguez, Adnan; Raymondie, Chloé; Davies, Emma; Smith, Aaron; Wilson, Joanne; Howes, Colin; Smith, Paul D.; Cassoux, Nathalie; Piperno-Neumann, Sophie; Roman-Roman, Sergio; Némati, Fariba

    2018-01-01

    The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, based on MEK inhibition, for example. We evaluated the potential of drug combinations to increase the efficacy of the MEK inhibitor selumetinib (AZD6244, ARRY-142886), in UM cell lines and Patient-Derived Xenografts. We first evaluated the combination of selumetinib and DTIC. We found that DTIC did not improve the in vitro or in vivo antitumor efficacy of selumetinib, consistent with the outcome of the SUMIT clinical trial assessing the efficacy of this combination in UM. We then tested additional selumetinib combinations with the chemotherapy agent docetaxel, the ERK inhibitor AZ6197, and the mTORC1/2 inhibitor, vistusertib (AZD2014). Combinations of selumetinib with ERK and mTORC1/2 inhibitors appeared to be the most effective in UM PDX models. PMID:29774094

  14. Immunostaining, dehydration, and clearing of mouse embryos for ultramicroscopy.

    PubMed

    Becker, Klaus; Jährling, Nina; Saghafi, Saiedeh; Dodt, Hans-Ulrich

    2013-08-01

    This protocol describes the preparation of mouse embryos for ultramicroscopy (UM), a powerful imaging technique that achieves precise and accurate three-dimensional (3D) reconstructions of intact macroscopic specimens with micrometer resolution. In UM, a specimen in the size range of ∼1-15 mm is illuminated perpendicular to the observation pathway by two thin counterpropagating sheets of laser light. In combination with fluorescein isothiocyanate (FITC) immunostaining, UM allows visualization of somatic motor and sensorial nerve fibers in whole mouse embryos. Even the fine branches of the sensomotoric fibers can be visualized over a distance of up to several millimeters. In this protocol, mouse embryos are fixed and immunostained in preparation for UM. Because UM requires the excitation light sheet to travel throughout the entire horizontal width of the specimen, specimens usually have to be rendered transparent before microscope inspection. Here, the embryos are dehydrated in ethanol and then cleared in a solution of benzyl alcohol and benzyl benzoate.

  15. The mental health of unaccompanied refugee minors on arrival in the host country.

    PubMed

    Vervliet, Marianne; Meyer Demott, Melinda A; Jakobsen, Marianne; Broekaert, Eric; Heir, Trond; Derluyn, Ilse

    2014-02-01

    Despite increasing numbers of unaccompanied refugee minors (UM) in Europe and heightened concerns for this group, research on their mental health has seldom included the factor "time since arrival." As a result, our knowledge of the mental health statuses of UM at specific points in time and over periods in their resettlement trajectories in European host countries is limited. This study therefore examined the mental health of UM shortly after their arrival in Norway (n = 204) and Belgium (n = 103) through the use of self-report questionnaires (HSCL-37A, SLE, RATS, HTQ). High prevalence scores of anxiety, depression and posttraumatic stress disorder (PTSD) symptoms were found. In addition, particular associations were found with the number of traumatic events the UM reported. The results indicate that all UM have high support needs on arrival in the host country. Longitudinal studies following up patterns of continuity and change in their mental health during their trajectories in the host country are necessary. © 2014 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  16. [Comparing the Application of Hema-Obs RSS to 250 Pregnancies from Obstetrics/Hematology Consultation in Centro Hospitalar São João, Portugal with the Application of Galit Sarig RSS to 90 Pregnancies from Rambam Health Care Campus, Israel].

    PubMed

    Salselas, Ana; Pestana, Inês; Bischoff, Francisco; Guimarães, Mariana; Andrade, Joaquim Aguiar

    2015-01-01

    Pregnant women with thromboembolic diseases, previous thrombotic episodes or thrombophilia family history were supervised in a multidisciplinary Obstetrics/ Hematology consultation in Centro Hospitalar São João EPE, Porto, Portugal. For the evaluation and medication of these women, a risk stratification scale was used. The aim of this study was to validate a Risk Stratification Scale and thromboprophylaxis protocol by means of comparing it with a similar scale, developed and published by Sarig. We have compared: The distribution, by risk groups, obtained through the application of the two scales on pregnant women followed at Centro Hospitalar São João, Porto, Portugal, consultation; the sensibility and specificity for each one of the scales (DeLong scale, applied to Receiver Operating Characteristic) curves; the outcomes in pregnancies followed in Hospital São João, Porto, PortugalResults: According to our Hema-Obs risk stratification scale, 29% were allocated to low-risk, 47% to high-risk and 24% to very-high-risk groups. According to Galit Sarig risk stratification scale, 24% were considered low-risk, 53% moderate, 16% high-risk and 7% as very high-risk group. In our study we observed 9% of spontaneous abortions, in comparison with 18% in the Galit Sarig cohort. From the application of Receiver Operating Characteristic curve to both risk stratification scales, the results of the calculated areas were 58,8% to our Hema-Obs risk stratification scale and 38,7% to Galit Sarig risk stratification scale, with a Delong test significancie of p = 0.0006. We concluded that Hema-Obs risk stratification scale is an effective support for clinical monitoring of therapeutic strategies.

  17. Learning to associate novel words with motor actions: language-induced motor activity following short training.

    PubMed

    Fargier, Raphaël; Paulignan, Yves; Boulenger, Véronique; Monaghan, Padraic; Reboul, Anne; Nazir, Tatjana A

    2012-07-01

    Action words referring to face, arm or leg actions activate areas along the motor strip that also control the planning and execution of the actions specified by the words. This electroencephalogram (EEG) study aimed to test the learning profile of this language-induced motor activity. Participants were trained to associate novel verbal stimuli to videos of object-oriented hand and arm movements or animated visual images on two consecutive days. Each training session was preceded and followed by a test-session with isolated videos and verbal stimuli. We measured motor-related brain activity (reflected by a desynchronization in the μ frequency bands; 8-12 Hz range) localized at centro-parietal and fronto-central electrodes. We compared activity from viewing the videos to activity resulting from processing the language stimuli only. At centro-parietal electrodes, stable action-related μ suppression was observed during viewing of videos in each test-session of the two days. For processing of verbal stimuli associated with motor actions, a similar pattern of activity was evident only in the second test-session of Day 1. Over the fronto-central regions, μ suppression was observed in the second test-session of Day 2 for the videos and in the second test-session of Day 1 for the verbal stimuli. Whereas the centro-parietal μ suppression can be attributed to motor events actually experienced during training, the fronto-central μ suppression seems to serve as a convergence zone that mediates underspecified motor information. Consequently, sensory-motor reactivations through which concepts are comprehended seem to differ in neural dynamics from those implicated in their acquisition. Copyright © 2011 Elsevier Srl. All rights reserved.

  18. Driving bubbles out of glass

    NASA Technical Reports Server (NTRS)

    Mattox, D. M.

    1981-01-01

    Surface tension gradient in melt forces gas bubbles to surface, increasing glass strength and transparency. Conventional chemical and buoyant fining are extremely slow in viscous glasses, but tension gradient method moves 250 um bubbles as rapidly as 30 um/s. Heat required for high temperature part of melt is furnished by stationary electrical or natural-gas heater; induction and laser heating are also possible. Method has many applications in industry processes.

  19. Genetic heterogeneity in uveal melanoma assessed by multiplex ligation-dependent probe amplification.

    PubMed

    Dopierala, Justyna; Damato, Bertil E; Lake, Sarah L; Taktak, Azzam F G; Coupland, Sarah E

    2010-10-01

    To determine intratumor genetic heterogeneity in uveal melanoma (UM) by multiplex ligation-dependent probe amplification (MLPA) in formalin-fixed, paraffin-embedded (FFPE) tumor tissues. DNA was extracted from whole tumor sections and from two to nine different areas microdissected from 32 FFPE UMs. Thirty-one loci on chromosomes 1, 3, 6, and 8 were tested with MLPA for copy number changes. The tumor was considered heterogeneous at a locus if (1) the difference in dosage quotients (DQs) of any two areas was 0.2 or more, and (2) the DQs of the areas belonged to different ranges. Comparison of MLPA data obtained from microdissected areas of the UMs showed heterogeneity in 1 to 26 examined loci in 24 (75%) tumors, with only 25% of the tumors being homogeneous. Intratumor heterogeneity of 3p12.2, 6p21.2, and 8q11.23 was most common, occurring in >30% of the UMs. Gains of chromosome 3 were observed in four UMs, with three of these tumors showing the highest degree of heterogeneity. Copy number variation was associated with differences in tumor cell type, but not with differences in tumor pigmentation or reactive inflammation. UMs with genetic heterogeneity across multiple sample sites showed equivocal MLPA results when the whole tumor section was examined. These results suggest that different clones dilute MLPA results. Heterogeneity of chromosomal abnormalities of chromosomes 1, 3, 6, and 8 is present in most UMs. This heterogeneity causes equivocal MLPA results. One random tumor sample may not be representative of the whole tumor and, therefore, may be insufficient for prognostic testing.

  20. Genomic insight into pathogenicity of dematiaceous fungus Corynespora cassiicola

    PubMed Central

    Looi, Hong Keat; Toh, Yue Fen; Yew, Su Mei; Na, Shiang Ling; Tan, Yung-Chie; Chong, Pei-Sin; Khoo, Jia-Shiun; Yee, Wai-Yan; Ng, Kee Peng

    2017-01-01

    Corynespora cassiicola is a common plant pathogen that causes leaf spot disease in a broad range of crop, and it heavily affect rubber trees in Malaysia (Hsueh, 2011; Nghia et al., 2008). The isolation of UM 591 from a patient’s contact lens indicates the pathogenic potential of this dematiaceous fungus in human. However, the underlying factors that contribute to the opportunistic cross-infection have not been fully studied. We employed genome sequencing and gene homology annotations in attempt to identify these factors in UM 591 using data obtained from publicly available bioinformatics databases. The assembly size of UM 591 genome is 41.8 Mbp, and a total of 13,531 (≥99 bp) genes have been predicted. UM 591 is enriched with genes that encode for glycoside hydrolases, carbohydrate esterases, auxiliary activity enzymes and cell wall degrading enzymes. Virulent genes comprising of CAZymes, peptidases, and hypervirulence-associated cutinases were found to be present in the fungal genome. Comparative analysis result shows that UM 591 possesses higher number of carbohydrate esterases family 10 (CE10) CAZymes compared to other species of fungi in this study, and these enzymes hydrolyses wide range of carbohydrate and non-carbohydrate substrates. Putative melanin, siderophore, ent-kaurene, and lycopene biosynthesis gene clusters are predicted, and these gene clusters denote that UM 591 are capable of protecting itself from the UV and chemical stresses, allowing it to adapt to different environment. Putative sterigmatocystin, HC-toxin, cercosporin, and gliotoxin biosynthesis gene cluster are predicted. This finding have highlighted the necrotrophic and invasive nature of UM 591. PMID:28149676

  1. Origins Space Telescope: The Far Infrared Imager and Polarimeter FIP

    NASA Astrophysics Data System (ADS)

    Staguhn, Johannes G.; Chuss, David; Howard, Joseph; Meixner, Margaret; Vieira, Joaquin; Amatucci, Edward; Bradley, Damon; Carter, Ruth; Cooray, Asantha; Flores, Anel; Leisawitz, David; Moseley, Samuel Harvey; Wollack, Edward; Origins Space Telescope Study Team

    2018-01-01

    The Origins Space Telescope (OST)* is the mission concept for the Far-Infrared Surveyor, one of the four science and technology definition studies of NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey. The current "concept 1", which envisions a cold (4K) 9m space telescope, includes 5 instruments, providing a wavelength coverage ranging from 6um and 667um. The achievable sensitivity of the observatory will provide three to four orders of magnitude of improvement in sensitivity over current observational capabilities, allowing to address a wide range of new and so far inaccessible scientific questions, ranging from bio-signatures on exo-planets to mapping primordial H_2 from the "dark ages" before the universe went through the phase of re-ionization.Here we present the Far Infrared Imager and Polarimeter (FIP) for OST. The cameral will cover four bands, 40um, 80um, 120um, and 240um. It will allow for differential polarimetry in those bands with the ability to observe two colors in polarimtery mode simultaneously, while all four bands can be observed simultaneously in total power mode. While the confusion limit will be reached in only 32ms at 240um, at 40um the source density on the sky is so low, that at the angular resolution of 1" of OST at this wavelength there will be no source confusion, even for the longest integration times. Science topics that can be addressed by FIP include but are not limited to galactic and extragalactic magnetic field studies, Deep Galaxy Surveys, and Outer Solar System objects..*Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. We welcome you to contact the Science and Technology Definition Team (STDT) with your science needs and ideas by emailing us at ost_info@lists.ipac.caltech.edu

  2. Measuring Broadband IR Irradiance in the Direct Solar Beam and Recent Developments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reda, Ibrahim; Andreas, Afshin; Dooraghi, Mike

    2016-12-14

    Solar and atmospheric science radiometers such as pyranometers, pyrheliometers, and photovoltaic cells are calibrated with traceability to a consensus reference which is maintained by Absolute Cavity Radiometers (ACRs). An ACR is an open cavity with no window, developed to measure the extended broadband spectrum of the terrestrial direct solar beam irradiance that extends beyond the ultraviolet and infrared bands; i.e. below 0.2 um and above 50 um, respectively. On the other hand, the pyranometers and pyrheliometers were developed to measure broadband shortwave irradiance from approximately 0.3 um to 3 um, while the present photovoltaic cells are limited to the spectralmore » range of approximately 0.3 um to 1 um. The broadband mismatch of ACR versus such radiometers causes discrepancy in radiometers' calibration methods that has not been discussed or addressed in the solar and atmospheric science literature. Pyrgeometers, which measure the atmospheric longwave irradiance, are also used for solar and atmospheric science applications and calibrated with traceability to a consensus reference, yet they are calibrated during nighttime only, because no consensus reference has been established for the daytime longwave irradiance. This poster describes a method to measure the broadband longwave irradiance in the terrestrial direct solar beam from 3 um to 50 um, as a first step that might be used to help develop calibration methods to address the mismatch between broadband ACR and shortwave radiometers, and the lack of a daytime reference for pyrgeometers. The described method is used to measure the irradiance from sunrise to sunset; the irradiance varied from approximately 1 Wm-2 to 16 Wm-2 with an estimated uncertainty of 1.5 Wm-2, for a solar zenith angle range from 80 degrees to 16 degrees, respectively. Recent development shows that there is greater than 1.1 percent bias in measuring shortwave solar irradiance.« less

  3. Assessment of laparoscopic skills of Gynecology and Obstetrics residents after a training program.

    PubMed

    Fernandes, Carla Ferreira Kikuchi; Ruano, José Maria Cordeiro; Kati, Lea Mina; Noguti, Alberto Sinhiti; Girão, Manoel João Batista Castello; Sartori, Marair Gracio Ferreira

    2016-01-01

    To evaluate laparoscopic skills of third-year Gynecology and Obstetrics residents after training at a training and surgical experimentation center. Use of a prospective questionnaire analyzing demographic data, medical residency, skills, competences, and training in a box trainer and in pigs. After the training, there was significant improvement in laparoscopic skills according to the residents (before 1.3/after 2.7; p=0.000) and preceptors (before 2.1/after 4.8; p=0.000). There was also significant improvement in the feeling of competence in surgeries with level 1 and 2 of difficulty. All residents approved the training. The training was distributed into 12 hours in the box trainer and 20 hours in animals, and led to better laparoscopic skills and a feeling of more surgical competence in laparoscopic surgery levels 1 and 2. Avaliar a habilidade laparoscópica dos residentes do terceiro ano de residência médica em Ginecologia e Obstetrícia após treinamento em um centro de treinamento e experimentação cirúrgica. Aplicação de questionário de forma prospectiva analisando dados demográficos, da residência médica, da habilidade, da competência e do treinamento em caixa preta e em porcas. Após o treinamento, houve melhora da habilidade em laparoscopia de forma significativa na avaliação dos residentes (antes 1,3/depois 2,7; p=0,000) e preceptores (antes 2,1/depois 4,8; p=0,000). Houve melhora significativa na sensação de competência em cirurgias de níveis 1 e 2 de dificuldade. Todos os residentes aprovaram o treinamento. O treinamento dividido em 12 horas de caixa preta e 20 horas em animais trouxe melhora na habilidade em laparoscopia e na sensação de melhora na competência cirúrgica em cirurgias laparoscópicas de níveis 1 e 2.

  4. Nursing terminology as a work process instrument of nurses in collective health.

    PubMed

    Cavalcante, Marília Daniella Machado Araújo; Larocca, Liliana Müller; Chaves, Maria Marta Nolasco; Cubas, Márcia Regina; Piosiadlo, Laura Christina Macedo; Mazza, Verônica de Azevedo

    2016-01-01

    To analyze the use of nursing terminology as an instrument of the nursing work process in Collective Health. Exploratory case study. For data collection was conducted a group interview with 24 nurses working in health units of a municipality in south central Paraná, Brazil. Data were analyzed in the light of interdependence between the structural, particular and singular dimensions contained in the Theory of Nursing Praxis Intervention in Collective Health. The situations interfering with improper use were the lack of knowledge about the origin and purpose of terminology, lack of training, and non-mandatory use. Although the nursing terminology is used as an instrument in the nursing work process in collective health, it requires training to be recognized as a classification system. At the same time, institutional policies should be employed to ensure the effective use of these instruments. Analisar a utilização de terminologia de enfermagem como instrumento do processo de trabalho do enfermeiro em Saúde Coletiva. Estudo de caso exploratório. Para coleta de dados foi realizada entrevista em grupo com 24 enfermeiros que atuam nas unidades de saúde de um município no centro-sul do Paraná, Brasil. Os dados foram analisados à luz da interdependência entre as dimensões estrutural, particular e singular contidas na Teoria da Intervenção Práxica de Enfermagem em Saúde Coletiva. As situações que interferiram na utilização inadequada foram o desconhecimento sobre origem e finalidade da terminologia, a falta de treinamento e a não obrigatoriedade de uso. A terminologia de enfermagem, apesar de utilizada como instrumento no processo de trabalho de enfermeiros em Saúde Coletiva, necessita de capacitação para ser reconhecida como sistema classificatório. Ao mesmo tempo, políticas institucionais devem ser empregadas no intuito de garantir a efetiva utilização destes instrumentos.

  5. Educators Exchange: A Program Evaluation.

    ERIC Educational Resources Information Center

    Armstrong, William B.

    The Educators Exchange Program (EEP) was established under a training and educational exchange agreement reached by California's San Diego Community College District (SDCCD) and the republic of Mexico. In the program, the District provided a 4-week technological training program to faculty at Centros de Capacitacion Tecnologica Industrial…

  6. The Mexican Seismic Network (Red Sísmica Mexicana)

    NASA Astrophysics Data System (ADS)

    Valdes-Gonzales, C. M.; Arreola-Manzano, J.; Castelan-Pescina, G.; Alonso-Rivera, P.; Saldivar-Rangel, M. A.; Rodriguez-Arteaga, O. O.; Lopez-Lena-Villasana, R.

    2014-12-01

    The Mexican Seismic Network (Red Sísmica Mexicana) was created to give sufficient information and opportune to make decisions in order to mitigate seismic and tsunami risk. This was a Mexican government initiative headed by CENAPRED (National Disaster Prevention Center) who made an effort to integrated academic institutions and civil agencies to work together through a collaboration agreement. This network is supported by Universidad National Autónoma de México (UNAM) and its seismic networks (Broad Band and Strong Motion), the Centro de Instrumentación y Registro Sismico (CIRES) with its Earthquake Early Warning System that covers the Guerrero Gap and Oaxaca earthquakes, The Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE) with the support of its expertise in tsunami observation and the Secretaria de Marina (SEMAR) to monitor the sea level and operate the Mexican Tsunami Warning Center. The institutions involved in this scope have the compromise to interchange and share the data and advice to the Civil Protection authorities.

  7. [Frequency of depression in patients with diabetes mellitus type 2].

    PubMed

    Garduño-Espinosa, J; Téllez-Zenteno, J F; Hernández-Ronquillo, L

    1998-01-01

    To determine the prevalence of depression in Mexican adult diabetics and to identify factors associated to the depression. Prolective survey. Four Mexico City hospitals (Clinica San Pedro de los Pinos IMSS, Centro Medico Nacional Siglo XXI IMSS, Hospital Gea González SSa and Centro de Salud Margarita Chorne SSa). 79 patients with diabetes mellitus type 2. The Beck Depression Inventory was used as a measure of depression. We used sociodemographic variables (age, gender, marital status, religion, education, occupation, socioeconomic status) and disease variables (years of diagnosis, other chronic medical conditions and compliance with therapeutic regimens) as the independent variables of depression. Mean age was 59 +/- 11 years (SD) and 58 (73%) were females. The frequency of depression was 46%. Factors associated to depression were: females (OR = 3.67, CI = 1.07-13.3, p = 0.03) and years of diagnosis above 15 (OR = 3.08, CI = 0.91-10.8, p = 0.07). Frequency of depression was high (46%). Gender and years of diabetes diagnosis were factors associated to depression.

  8. A Study on the Data Compression Technology-Based Intelligent Data Acquisition (IDAQ) System for Structural Health Monitoring of Civil Structures

    PubMed Central

    Jeon, Joonryong

    2017-01-01

    In this paper, a data compression technology-based intelligent data acquisition (IDAQ) system was developed for structural health monitoring of civil structures, and its validity was tested using random signals (El-Centro seismic waveform). The IDAQ system was structured to include a high-performance CPU with large dynamic memory for multi-input and output in a radio frequency (RF) manner. In addition, the embedded software technology (EST) has been applied to it to implement diverse logics needed in the process of acquiring, processing and transmitting data. In order to utilize IDAQ system for the structural health monitoring of civil structures, this study developed an artificial filter bank by which structural dynamic responses (acceleration) were efficiently acquired, and also optimized it on the random El-Centro seismic waveform. All techniques developed in this study have been embedded to our system. The data compression technology-based IDAQ system was proven valid in acquiring valid signals in a compressed size. PMID:28704945

  9. A Study on the Data Compression Technology-Based Intelligent Data Acquisition (IDAQ) System for Structural Health Monitoring of Civil Structures.

    PubMed

    Heo, Gwanghee; Jeon, Joonryong

    2017-07-12

    In this paper, a data compression technology-based intelligent data acquisition (IDAQ) system was developed for structural health monitoring of civil structures, and its validity was tested using random signals (El-Centro seismic waveform). The IDAQ system was structured to include a high-performance CPU with large dynamic memory for multi-input and output in a radio frequency (RF) manner. In addition, the embedded software technology (EST) has been applied to it to implement diverse logics needed in the process of acquiring, processing and transmitting data. In order to utilize IDAQ system for the structural health monitoring of civil structures, this study developed an artificial filter bank by which structural dynamic responses (acceleration) were efficiently acquired, and also optimized it on the random El-Centro seismic waveform. All techniques developed in this study have been embedded to our system. The data compression technology-based IDAQ system was proven valid in acquiring valid signals in a compressed size.

  10. UM-PRS: An implementation of the procedural reasoning system for multirobot applications

    NASA Technical Reports Server (NTRS)

    Lee, Jaeho; Huber, Marcus J.; Durfee, Edmund H.; Kenny, Patrick G.

    1994-01-01

    The Procedural Reasoning System (PRS) is used in applications where predetermined situations might arise. The UM-PRS provides a reasoning system that represents robotic applications even in unpredictable domains, such as the robotic reconnaissance task domain outlined here. UM-PRS incorporates a changing context, rather than relying solely on a prearranged plan. The UM-PRS here provides representation important in the reasoning and interface between a mission plan and the executable map of an outdoor vehicle that changes its behavior based on what it comes in contact with in its environment. PRS is thus used in the dynamic control of such a vehicle, providing the basis for coordinating the joint task of multiple robotic vehicles by the their individual observations and representation.

  11. VizieR Online Data Catalog: FIR spectra of AGNs from Herschel (Fernandez-Ontiveros+, 2016)

    NASA Astrophysics Data System (ADS)

    Fernandez-Ontiveros, J. A.; Spinoglio, L.; Pereira-Santaella, M.; Malkan, M. A.; Andreani, P.; Dasyra, K. M.

    2016-11-01

    The combination of Herschel/PACS during its 3.5yr of operational life and Spitzer/IRS allows us to cover the fine-structure emission lines from the mid- to the far-IR (10-200um in the rest-frame) for all the galaxies in the sample. This database was completed with the Herschel/SPIRE published values of the [NII]205um, and [CI]371,609um line fluxes (mainly from Kamenetzky+ 2016ApJ...829...93K). Table 8 collects published mid-IR (10-35um) fine-structure line fluxes measured with Spitzer/IRS for our samples of AGN and starburst galaxies. These values were complemented with unpublished IRS observations from the Spitzer archive. (10 data files).

  12. Outreach to Future Hispanic Educational Leaders.

    ERIC Educational Resources Information Center

    Serafin, Ana Gil

    This paper discusses issues related to the recruitment of Hispanic-American educational leaders, focusing on the El Centro de Recursos Educativos outreach center at Northeastern Illinois University in Chicago, which began operation in Fall 1997. It examines the characteristics of successful programs for Hispanic recruitment and retention and the…

  13. SOLAR PHOTOVOLTAIC AND WASTEWATER TREATMENT SYSTEMS DESIGN FOR COMMUNITIES IN PANAM&AACUTE;

    EPA Science Inventory

    In collaboration with the Panamanian non-governmental organization Centro de Estudios y Acción Social Panameño (CEASPA), the Northwestern University chapter of Engineers for a Sustainable World (ESW-NU) has been working with the rural ranching community of San...

  14. Entrance into Registered Nursing--Issues and Problems.

    ERIC Educational Resources Information Center

    Herd, Ruby H.

    Following a description of the facilities, programs, and students of El Centro College (Texas), this paper reviews the conflicts arising between the mandates of external certifying boards, the expectations of hospital administrators and other medical personnel, and the realities of community college philosophy, planning, staffing and budgeting for…

  15. Chaos in non-diagonal spatially homogeneous cosmological models in spacetime dimensions <=10

    NASA Astrophysics Data System (ADS)

    Demaret, Jacques; de Rop, Yves; Henneaux, Marc

    1988-08-01

    It is shown that the chaotic oscillatory behaviour, absent in diagonal homogeneous cosmological models in spacetime dimensions between 5 and 10, can be reestablished when off-diagonal terms are included. Also at Centro de Estudios Cientificos de Santiago, Casilla 16443, Santiago 9, Chile

  16. Monitoring the Near-infrared Volcanic Flux from Io's Jupiter-facing Hemisphere from Fan Mountain Observatory

    NASA Astrophysics Data System (ADS)

    Skrutskie, Michael F.; Nelson, Matthew J.; Schmidt, Carl

    2016-10-01

    Fan Mountain Observatory, near Charlottesville, Virginia, is a dark-sky site that supports a number of telescopes including a 31-inch reflecting telescope equipped with a 1024x1024 HgCdTe 1-2.5 um (YJHK) imager. Reflected sunlight ordinarily overwhelms Io's comparatively weak K-band (2.0-2.4 um) volcanic emission in unresolved observations, however when Io is eclipsed in Jupiter's shadow even a small infrared-equipped telescope can detect Io's volcanic emission. The Fan Mountain Infrared Camera observed Io in eclipse at regular intervals, typically weekly, during the few months before and after Jupiter's March 2016 opposition. When in eclipse Io's Jupiter-facing hemisphere is oriented toward Earth with sub-Earth longitudes at the time of observation ranging from 345 - 360 degrees (pre-opposition) to 0 - 15 degrees (post-opposition). A K-band filter (2.04-2.42 um) provided a bulk measurement of Io's volcanic flux weighted largely toward the 2.4 um end of this filter given the typical 500K color temperature of the volcanic emission. Most epochs also included observation in a narrowband filter centered at 2.12 um that, when combined with the broadband "long" wavelength measurement, provided a proxy for color temperature. The K-band flux of Io varied by more than 2 magnitudes during the 7 month observation interval. The [2.12 um - K-band] color of the emission strongly correlated with the K-band flux in the expected sense that the color temperature of the emission increased when Io's broadband volcanic flux was the greatest. One epoch of TripleSpec near-IR Io eclipse spectroscopy (0.90 - 2.45 um; R~3000) from the Apache Point Observatory 3.5-meter telescope provided ground truth for transforming the filter photometry into quantitative temperatures.

  17. Genome analysis of Daldinia eschscholtzii strains UM 1400 and UM 1020, wood-decaying fungi isolated from human hosts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chan, Chai Ling; Yew, Su Mei; Ngeow, Yun Fong

    Background: Daldinia eschscholtzii is a wood-inhabiting fungus that causes wood decay under certain conditions. It has a broad host range and produces a large repertoire of potentially bioactive compounds. However, there is no extensive genome analysis on this fungal species. Results: Two fungal isolates (UM 1400 and UM 1020) from human specimens were identified as Daldinia eschscholtzii by morphological features and ITS-based phylogenetic analysis. Both genomes were similar in size with 10,822 predicted genes in UM 1400 (35.8 Mb) and 11,120 predicted genes in UM 1020 (35.5 Mb). A total of 751 gene families were shared among both UM isolates,more » including gene families associated with fungus-host interactions. In the CAZyme comparative analysis, both genomes were found to contain arrays of CAZyme related to plant cell wall degradation. Genes encoding secreted peptidases were found in the genomes, which encode for the peptidases involved in the degradation of structural proteins in plant cell wall. In addition, arrays of secondary metabolite backbone genes were identified in both genomes, indicating of their potential to produce bioactive secondary metabolites. Both genomes also contained an abundance of gene encoding signaling components, with three proposed MAPK cascades involved in cell wall integrity, osmoregulation, and mating/filamentation. Besides genomic evidence for degrading capability, both isolates also harbored an array of genes encoding stress response proteins that are potentially significant for adaptation to living in the hostile environments. In conclusion: Our genomic studies provide further information for the biological understanding of the D. eschscholtzii and suggest that these wood-decaying fungi are also equipped for adaptation to adverse environments in the human host.« less

  18. Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen.

    PubMed Central

    Fox, D A; Millard, J A; Kan, L; Zeldes, W S; Davis, W; Higgs, J; Emmrich, F; Kinne, R W

    1990-01-01

    Accumulating evidence implicates a central role for synovial T cells in the pathogenesis of rheumatoid arthritis, but the activation pathways that drive proliferation and effector function of these cells are not known. We have recently generated a novel monoclonal antibody against a rheumatoid synovial T cell line that recognizes an antigen termed UM4D4 (CDw60). This antigen is expressed on a minority of peripheral blood T cells, and represents the surface component of a distinct pathway of human T cell activation. The current studies were performed to examine the expression and function of UM4D4 on T cells obtained from synovial fluid and synovial membranes of patients with rheumatoid arthritis and other forms of inflammatory joint disease. The UM4D4 antigen is expressed at high surface density on about three-fourths of synovial fluid T cells and on a small subset of synovial fluid natural killer cells; in synovial tissue it is present on more than 90% of T cells in lymphoid aggregates, and on approximately 50% of T cells in stromal infiltrates In addition, UM4D4 is expressed in synovial tissue on a previously undescribed population of HLA-DR/DP-negative non-T cells with a dendritic morphology. Anti-UM4D4 was co-mitogenic for both RA and non-RA synovial fluid mononuclear cells, and induced IL-2 receptor expression. The UM4D4/CDw60 antigen may represent a functional activation pathway for synovial compartment T cells, which could play an important role in the pathogenesis of inflammatory arthritis. Images PMID:2212003

  19. Mental health problems of undocumented migrants (UMs) in the Netherlands: a qualitative exploration of help-seeking behaviour and experiences with primary care

    PubMed Central

    Teunissen, Erik; Sherally, Jamilah; van den Muijsenbergh, Maria; Dowrick, Chris; van Weel-Baumgarten, Evelyn; van Weel, Chris

    2014-01-01

    Objective To explore health-seeking behaviour and experiences of undocumented migrants (UMs) in general practice in relation to mental health problems. Design Qualitative study using semistructured interviews and thematic analysis. Participants 15 UMs in the Netherlands, varying in age, gender, country of origin and education; inclusion until theoretical saturation was reached. Setting 4 cities in the Netherlands. Results UMs consider mental health problems to be directly related to their precarious living conditions. For support, they refer to friends and religion first, the general practitioner (GP) is their last resort. Barriers for seeking help include taboo on mental health problems, lack of knowledge of and trust in GPs competencies regarding mental health and general barriers in accessing healthcare as an UM (lack of knowledge of the right to access healthcare, fear of prosecution, financial constraints and practical difficulties). Once access has been gained, satisfaction with care is high. This is primarily due to the attitude of the GPs and the effectiveness of the treatment. Reasons for dissatisfaction with GP care are an experienced lack of time, lack of personal attention and absence of physical examination. Expectations of the GP vary, medication for mental health problems is not necessarily seen as a good practice. Conclusions UMs often see their precarious living conditions as an important determinant of their mental health; they do not easily seek help for mental health problems and various barriers hamper access to healthcare for them. Rather than for medication, UMs are looking for encouragement and support from their GP. We recommend that barriers experienced in seeking professional care are tackled at an institutional level as well as at the level of GP. PMID:25416057

  20. Comparison of gene delivery techniques for therapeutic angiogenesis ultrasound-mediated destruction of carrier microbubbles versus direct intramuscular injection.

    PubMed

    Kobulnik, Jeremy; Kuliszewski, Michael A; Stewart, Duncan J; Lindner, Jonathan R; Leong-Poi, Howard

    2009-10-27

    This study was designed to compare the efficacy of angiogenic gene delivery by ultrasound-mediated (UM) destruction of intravenous carrier microbubbles to direct intramuscular (IM) injections. Current trials of gene therapy for angiogenesis remain limited by suboptimal, invasive delivery techniques. Hind-limb ischemia was produced by iliac artery ligation in 99 rats. In 32 rats, UM delivery of green fluorescent protein (GFP)/vascular endothelial growth factor-165 (VEGF(165)) plasmid deoxyribonucleic acid was performed. Thirty-five animals received IM injections of VEGF(165)/GFP plasmid. Remaining rats received no treatment. Before delivery (day 14 after ligation) and at days 17, 21, and 28 and week 8 after ligation, microvascular blood volume and microvascular blood flow to the proximal hind limbs were assessed by contrast-enhanced ultrasound (n = 8 per group). Total transfection was assessed by reverse transcriptase-polymerase chain reaction, and localization of transfection was determined by immunohistochemistry. By day 28, both IM and UM delivery of VEGF(165) produced significant increases in microvascular blood volume and microvascular blood flow. Whereas increases in microvascular blood volume were similar between treatment groups, microvascular blood flow was greater (p < 0.005) in UM-treated animals as compared with IM-treated animals, persisting to week 8. The VEGF(165)/GFP messenger ribonucleic acid expression was greater (p < 0.05) for IM-treated animals. A strong GFP signal was detected for both groups and was localized to focal perivascular regions and myocytes around injection sites for IM and to the vascular endothelium of arterioles/capillaries in a wider distribution for UM delivery. Despite lower transfection levels, UM delivery of VEGF(165) is as effective as IM injections. The UM delivery results in directed vascular transfection over a wider distribution, which may account for the more efficient angiogenesis.

  1. Mental health problems of undocumented migrants in the Netherlands: A qualitative exploration of recognition, recording, and treatment by general practitioners.

    PubMed

    Teunissen, Erik; Van Bavel, Eric; Van Den Driessen Mareeuw, Francine; Macfarlane, Anne; Van Weel-Baumgarten, Evelyn; Van Den Muijsenbergh, Maria; Van Weel, Chris

    2015-06-01

    To explore the views and experiences of general practitioners (GPs) in relation to recognition, recording, and treatment of mental health problems of undocumented migrants (UMs), and to gain insight in the reasons for under-registration of mental health problems in the electronic medical records. Qualitative study design with semi-structured interviews using a topic guide. Sixteen GPs in the Netherlands with clinical expertise in the care of UMs. GPs recognized many mental health problems in UMs. Barriers that prevented them from recording these problems and from delivering appropriate care were their low consultation rates, physical presentation of mental health problems, high number of other problems, the UM's lack of trust towards health care professionals, and cultural differences in health beliefs and language barriers. Referrals to mental health care organizations were often seen as problematic by GPs. To overcome these barriers, GPs provided personalized care as far as possible, referred to other primary care professionals such as social workers or mental health care nurses in their practice, and were a little less restrictive in prescribing psychotropics than guidelines recommended. GPs experienced a variety of barriers in engaging with UMs when identifying or suspecting mental health problems. This explains why there is a gap between the high recognition of mental health problems and the low recording of these problems in general practice files. It is recommended that GPs address mental health problems more actively, strive for continuity of care in order to gain trust of the UMs, and look for opportunities to provide mental care that is accessible and acceptable for UMs.

  2. Protective Effects of Ultramicronized Palmitoylethanolamide (PEA-um) in Myocardial Ischaemia and Reperfusion Injury in VIVO.

    PubMed

    Di Paola, Rosanna; Cordaro, Marika; Crupi, Rosalia; Siracusa, Rosalba; Campolo, Michela; Bruschetta, Giuseppe; Fusco, Roberta; Pugliatti, Pietro; Esposito, Emanuela; Cuzzocrea, Salvatore

    2016-08-01

    Myocardial infarction is the leading cause of death, occurs after prolonged ischemia of the coronary arteries. Restore blood flow is the first intervention help against heart attack. However, reperfusion of the arteries leads to ischemia/reperfusion injury (I/R). The fatty acid amide palmitoylethanolamide (PEA) is an endogenous compound widely present in living organisms, with analgesic and anti-inflammatory properties. The present study evaluated the effect of ultramicronized palmitoylethanolamide (PEA-um) treatment on the inflammatory process associated with myocardial I/R. Myocardial ischemia reperfusion injury was induced by occlusion of the left anterior descending coronary artery for 30 min followed by 2 h of reperfusion. PEA-um, was administered (10 mg/kg) 15 min after ischemia and 1 h after reperfusion. In this study, we demonstrated that PEA-um treatment reduces myocardial tissue injury, neutrophil infiltration, adhesion molecules (ICAM-1, P-selectin) expression, proinflammatory cytokines (TNF-α, IL-1β) production, nitrotyrosine and PAR formation, nuclear factor kB expression, and apoptosis (Fas-L, Bcl-2) activation. In addition to study whether the protective effect of PEA-um on myocardial ischemia reperfusion injury is also related to the activation of PPAR-α, in a separate set of experiments it has been performed myocardial I/R in PPARα mice. Genetic ablation of peroxisome proliferator activated receptor (PPAR)-α in PPAR-αKO mice exacerbated Myocardial ischemia reperfusion injury when compared with PPAR-αWT mice. PEA-um induced cardioprotection in PPAR-α wild-type mice, but the same effect cannot be observed in PPAR-αKO mice. Our results have clearly shown a modulation of the inflammatory process, associated with myocardial ischemia reperfusion injury, following administration of PEA-um.

  3. Contralateral prophylactic mastectomy rate stable at major Canadian breast cancer center.

    PubMed

    Roberts, Amanda; Sandhu, Lakhbir; Cil, Tulin D; Hofer, Stefan O P; Zhong, Toni

    2016-06-10

    To examine trends of contralateral prophylactic mastectomy (CPM) rates at a Canadian academic breast cancer center. A single-institution retrospective cohort study was completed. Women of any age who underwent at least a unilateral mastectomy (UM) for primary unilateral breast carcinoma between January 1, 2004 and December 31, 2010 were included. Patients who underwent CPM on the same day as UM were isolated to create two distinct cohorts. Patient and procedure characteristics were compared across groups using R software (version 3.1.0). The percentage of CPMs per year was determined. The Cochrane-Armitage test was used to assess the trend of CPMs over time. A P value of < 0.05 was considered significant. A total of 811 women met the inclusions/exclusion criteria; 759 (93.6%) underwent UM alone and 52 (6.4%) underwent UM with immediate CPM. The absolute number of procedures (UM and UM + CPM) increased over time, from 83 in 2004 to 147 in 2010 reflecting an increase in mastectomy volume. Annual CPM rates did not increase over time (P = 0.7) and varied between 2.6% to 10.7%. Family history of breast cancer [OR 3.6 (1.8-7.3)] and immediate reconstruction [10.0 (5.2-19.3)] were both significantly associated with CPM. Women who underwent CPM were younger (median age CPM 49 years vs UM 52 years, P < 0.0001) but age less than 50 years was not statistically associated with increased rates of CPM. CPM rates from 2004 to 2010 at a high-volume Canadian breast cancer center did not increase over time, in contrast to trends observed in the United States.

  4. First Asteroid Spectrometric Observations with BTA: 3045 Alois

    NASA Astrophysics Data System (ADS)

    Busarev, V. V.; Burenkov, A. N.; Pramskij, A. G.

    2001-11-01

    BTA, Russian 6-m telescope, was mainly used for faint stars and extragalactic objects observations. We have firstly performed with the telescope spectrometric observations of a main belt asteroid, 3045 Alois, and are planning to use it for Centaurs and Kuiper Belt objects spectrometry. We have obtained some results of the observations. Spectra of Alois were recorded on two nights of March 2001 (29/30 and 30/31) with a long slit spectrograph (UAGS + CCD) in the .38-.80 um spectral range. HD105633 (G5) [1] considered as a solar analog was also observed, and the data were used for calculation the asteroid reflectance spectra. It was found that reflectance spectra of Alois obtained on different nights have various continuum slopes and absorption features. The reflectance spectrum on 29/30 March had a flat continuum in the range .44-.65 um and absorption bands at .5 um (ab. 7 % with respect to the continuum) similar to that found on the E-type asteroid 2035 Stearns [2], and at .80 um (ab. 25 %). Another one on 30/31 March had a red continuum in the range .40-.67 um and absorption bands at .43 um (ab. 6 %) resembling absorption features found on some C-, M- and S-type asteroids [3, 4], and at .80 um (ab. 17 %). From the data and taking into account the mean heliocentric distance of 3045 Alois (3.13 AU) we suppose that the asteroid having irregular spectral characteristics may be of M- or E-type and possibly hydrated. Unfortunately, its albedo and rotational period remain still unknown. [1] Mermilliod J.-C. (1994) Bull. Inf. CDS 45, 3. [2] Fornasier S. and Lazzarine M. (2001) Icarus 152, 127-133. [3] Vilas F. et al. (1993) Icarus 102, 225-231. [4] Busarev V. V. (2001) LPSC XXXII, abs. 1927.

  5. Genome analysis of Daldinia eschscholtzii strains UM 1400 and UM 1020, wood-decaying fungi isolated from human hosts

    DOE PAGES

    Chan, Chai Ling; Yew, Su Mei; Ngeow, Yun Fong; ...

    2015-11-18

    Background: Daldinia eschscholtzii is a wood-inhabiting fungus that causes wood decay under certain conditions. It has a broad host range and produces a large repertoire of potentially bioactive compounds. However, there is no extensive genome analysis on this fungal species. Results: Two fungal isolates (UM 1400 and UM 1020) from human specimens were identified as Daldinia eschscholtzii by morphological features and ITS-based phylogenetic analysis. Both genomes were similar in size with 10,822 predicted genes in UM 1400 (35.8 Mb) and 11,120 predicted genes in UM 1020 (35.5 Mb). A total of 751 gene families were shared among both UM isolates,more » including gene families associated with fungus-host interactions. In the CAZyme comparative analysis, both genomes were found to contain arrays of CAZyme related to plant cell wall degradation. Genes encoding secreted peptidases were found in the genomes, which encode for the peptidases involved in the degradation of structural proteins in plant cell wall. In addition, arrays of secondary metabolite backbone genes were identified in both genomes, indicating of their potential to produce bioactive secondary metabolites. Both genomes also contained an abundance of gene encoding signaling components, with three proposed MAPK cascades involved in cell wall integrity, osmoregulation, and mating/filamentation. Besides genomic evidence for degrading capability, both isolates also harbored an array of genes encoding stress response proteins that are potentially significant for adaptation to living in the hostile environments. In conclusion: Our genomic studies provide further information for the biological understanding of the D. eschscholtzii and suggest that these wood-decaying fungi are also equipped for adaptation to adverse environments in the human host.« less

  6. Aircraft Natural/Artificial Icing

    DTIC Science & Technology

    2009-02-12

    LWC are 0.1 to 0.8 g/m3 for stratiform clouds and 0.2 to 2.5 g/m3 for cumuliform clouds. The drop size distribution in the cloud is usually...cloud hydrometeor size distributions from 0.5 to 50 um, particle shape (discrimination between water and ice), particle optical properties (refractive...index), precipitation size distributions from 25 um to 1550 um, liquid water content from 0.01 to 3 gm-3 and aircraft velocity and atmospheric

  7. Novel Preclinical Testing Strategies for Treatment of Metastatic Pheochromocytoma

    DTIC Science & Technology

    2013-09-01

    proliferation using this protocol as reported or with any modifications tested Medium Y27632 (uM) Hydrocortisone (ug/mL) Insulin (ug/mL) rhEGF...0 + + 0 + + 0 + 0 Medium Y27632 (uM) Hydrocortisone (ug/mL) Insulin (ug/mL) rhEGF (ng/mL) Adenine (ug/mL) Result...reported (1) except for cholera toxin, which was toxic to this tumor under these conditions 17 Medium Y27632 (uM) Hydrocortisone (ug/mL

  8. BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.

    PubMed

    Ambrosini, Grazia; Sawle, Ashley D; Musi, Elgilda; Schwartz, Gary K

    2015-10-20

    Uveal melanoma (UM) is an aggressive intraocular malignancy with limited therapeutic options. Both primary and metastatic UM are characterized by oncogenic mutations in the G-protein alpha subunit q and 11. Furthermore, nearly 40% of UM has amplification of the chromosomal arm 8q and monosomy of chromosome 3, with consequent anomalies of MYC copy number. Chromatin regulators have become attractive targets for cancer therapy. In particular, the bromodomain and extra-terminal (BET) inhibitor JQ1 has shown selective inhibition of c-Myc expression with antiproliferative activity in hematopoietic and solid tumors. Here we provide evidence that JQ1 had cytotoxic activity in UM cell lines carrying Gnaq/11 mutations, while in cells without the mutations had little effects. Using microarray analysis, we identified a large subset of genes modulated by JQ1 involved in the regulation of cell cycle, apoptosis and DNA repair. Further analysis of selected genes determined that the concomitant silencing of Bcl-xL and Rad51 represented the minimal requirement to mimic the apoptotic effects of JQ1 in the mutant cells, independently of c-Myc. In addition, administration of JQ1 to mouse xenograft models of Gnaq-mutant UM resulted in significant inhibition of tumor growth.Collectively, our results define BRD4 targeting as a novel therapeutic intervention against UM with Gnaq/Gna11 mutations.

  9. Unsaponifiable matter from oil of green coffee beans: cosmetic properties and safety evaluation.

    PubMed

    Wagemaker, Tais A L; Campos, Patrícia M B G Maia; Fernandes, Ana Sofia; Rijo, Patrícia; Nicolai, Marisa; Roberto, Amílcar; Rosado, Catarina; Reis, Catarina; Rodrigues, Luis M; Carvalho, Cássia Regina Limonta; Maia, Nilson Borlina; Guerreiro Filho, Oliveiro

    2016-10-01

    Unsaponifiable matter (UM), a fraction of green coffee oil (GCO) contains functional compounds responsible for desirable cosmetic properties such as UV-B absorption. To evaluate oil content and sun protection factor (SPF) variability of the two most important species of coffee and, the toxic and cytotoxic effects, as well as cosmetic properties, including antioxidant and antimicrobial activities of UM obtained from green Coffea arabica seed oil. The safety and potential cosmetic properties of UM extracted from green coffee oil (GCO) were evaluated by the brine shrimp viability and the MTT cytotoxicity assays. The SPF and antioxidant activity were evaluated using in vitro methods. Relevant cytotoxicity was found against keratinocytes for concentrations ≥25 µg/mL and in the brine shrimp assay (LC50 24 µg/mL). Antimicrobial and antioxidant activities (IC50 1448 µg/mL) were low in UM but SPF was 10 times higher than in GCO. UM is a novel potential UV-B absorbent but its use as a cosmetic ingredient should be better considered due to the considerable cytotoxicity shown in the experimental conditions described.

  10. Medusa consumption and prey selection of silver pomfret Pampus argenteus juveniles

    NASA Astrophysics Data System (ADS)

    Liu, Chunsheng; Zhuang, Zhimeng; Chen, Siqing; Shi, Zhaohong; Yan, Jingping; Liu, Changlin

    2014-01-01

    The current study explored Aurelia aurita and Rhopilema esculent um consumption by silver pomfret juveniles, as well as their prey selection between the two jellyfish species. Silver pomfret juveniles weighing 1±0.1 g actively preyed on both the species. Their daily A. aurita consumption was 11.6 times their own body weights regardless of the size of A. aurita medusae. Their daily R. esculent um consumption was 13, 9.1, 5, and 4.1 times their own body weights when the R. esculentum medusae were 10, 20, 30, and 40 mm in bell diameter, respectively. The survival rates of the R. esculent um were higher than those of the A. aurita. When the R. esculent um medusae were more than 30 mm in bell diameter, their survival rate exceeded 92%. Silver pomfrets serve as a type of potential predators on A. aurita in coastal waters, and they have little influence on R. esculent um with a size exceeding 30 mm. Besides, A. aurita may be able to be used as fish prey in silver pomfret artificial breeding.

  11. VizieR Online Data Catalog: Multiwavelength study of HII region S311 (Yadav+, 2016)

    NASA Astrophysics Data System (ADS)

    Yadav, R. K.; Pandey, A. K.; Sharma, S.; Ojha, D. K.; Samal, M. R.; Mallick, K. K.; Jose, J.; Ogura, K.; Richichi, A.; Irawati, P.; Kobayashi, N.; Eswaraiah, C.

    2017-11-01

    We observed the HII region S311 (centred on RA(2000)=07:52:24, DE(2000)=-26:24:58.40) in NIR broad-bands J (1.25um), H (1.63um) and Ks (2.14um) on 2010 March 3 using the Infrared Side Port Imager (ISPI) camera mounted on the CTIO Blanco 4-m telescope. We consider only those sources having error <0.1mag in all three bands, resulting in a final catalogue of 2671 point sources. The Spitzer-IRAC observations for the S311 region (PID 20726) were made on 2006 May 3 using the 3.6, 4.5, 5.8 and 8.0um bands and were downloaded from the Spitzer heritage archive (SHA). (4 data files).

  12. Wideband response of a terahertz-millimeter imager based on a 384x288 pixel uncooled bolometric detector

    NASA Astrophysics Data System (ADS)

    Terroux, Marc; Marchese, Linda; Bolduc, Martin; Mercier, Luc; Chevalier, Claude; Gagnon, Lucie; Tremblay, Bruno; Généreux, Francis; Paultre, Jacques-Edmond; Provençal, Francis; Beaupré, Patrick; Desroches, Yan; Châteauneuf, François; Bergeron, Alain

    2017-11-01

    In the past, bolometer-based imagers have been used for earth observation. Uncooled-bolometer based imagers are especially well suited for this due to their low power consumption. NIRST (New Infra-Red Sensor Technology), an example of an imager based on uncooled bolometers, monitors high temperature events on the ground related to fires and volcanic events, and will measure their physical parameters and takes measurements of sea surface temperatures mainly off the coast of South America as well as other targeted opportunities. NIRST has one band in the mid-wave infrared centered at 3.8 um with a bandwidth of 0.8 um, and two bands in the thermal infrared, centered respectively at 10.85 and 11.85 um with a bandwidth of 0.9 um.

  13. Urine Monitoring System

    NASA Technical Reports Server (NTRS)

    Feedback, Daniel L.; Cibuzar, Branelle R.

    2009-01-01

    The Urine Monitoring System (UMS) is a system designed to collect an individual crewmember's void, gently separate urine from air, accurately measure void volume, allow for void sample acquisition, and discharge remaining urine into the Waste Collector Subsystem (WCS) onboard the International Space Station. The Urine Monitoring System (UMS) is a successor design to the existing Space Shuttle system and will resolve anomalies such as: liquid carry-over, inaccurate void volume measurements, and cross contamination in void samples. The crew will perform an evaluation of airflow at the ISS UMS urinal hose interface, a calibration evaluation, and a full user interface evaluation. o The UMS can be used to facilitate non-invasive methods for monitoring crew health, evaluation of countermeasures, and implementation of a variety of biomedical research protocols on future exploration missions.

  14. VizieR Online Data Catalog: UKIDSS-DR7 Large Area Survey (Lawrence+ 2011)

    NASA Astrophysics Data System (ADS)

    UKIDSS Consortium

    2012-03-01

    The UKIRT Infrared Deep Sky Survey (UKIDSS) is a large-scale near-IR survey which aim is to cover 7500 square degrees of the Northern sky. The survey is carried out using the Wide Field Camera (WFCAM), with a field of view of 0.21 square degrees, mounted on the 3.8m United Kingdom Infra-red Telescope (UKIRT) in Hawaii. The Large Area Survey (LAS) covers an area of 4000 square degrees in high Galactic latitudes (extragalactic) in the four bands Y(1.0um) J(1.2um) H(1.6um) and K(2.2um) to a depth of K = 18.4. Details of the survey can be found in the in the paper by Lawrence et al. (2007MNRAS.379.1599L) (1 data file).

  15. Use of the University of Minnesota Biocatalysis/Biodegradation Database for study of microbial degradation

    PubMed Central

    2012-01-01

    Microorganisms are ubiquitous on earth and have diverse metabolic transformative capabilities important for environmental biodegradation of chemicals that helps maintain ecosystem and human health. Microbial biodegradative metabolism is the main focus of the University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD). UM-BBD data has also been used to develop a computational metabolic pathway prediction system that can be applied to chemicals for which biodegradation data is currently lacking. The UM-Pathway Prediction System (UM-PPS) relies on metabolic rules that are based on organic functional groups and predicts plausible biodegradative metabolism. The predictions are useful to environmental chemists that look for metabolic intermediates, for regulators looking for potential toxic products, for microbiologists seeking to understand microbial biodegradation, and others with a wide-range of interests. PMID:22587916

  16. Misalignment tolerant efficient inverse taper coupler for silicon waveguide

    NASA Astrophysics Data System (ADS)

    Wang, Peng; Michael, Aron; Kwok, Chee Yee; Chen, Ssu-Han

    2015-12-01

    This paper describes an efficient fiber to submicron silicon waveguide coupling based on an inversely tapered silicon waveguide embedded in a SiO2 waveguide that is suspended in air. The inverse taper waveguide consist of a 50um long and 240nm thick silicon that linearly taper in width from 500nm to 120nm, which is embedded in SiO2. The SiO2 waveguide is 6um wide and 10um long. The simulation results show that the coupling loss of this new approach is 2.7dB including the interface loss at the input and output. The tolerance to fiber misalignment at the input of the coupler is 2um in both horizontal and vertical directions for only 1.5dB additional loss.

  17. A Group of 500 Women Whose Health May Depart Notably From the Norm: Protocol for a Cross-Sectional Survey.

    PubMed

    Schnelle, Christoph; Minford, Eunice J; McHardy, Vanessa; Keep, Jane

    2017-11-23

    Longitudinal studies of women's health often seek to identify predictors of good health. Research has shown that following simple guidelines can halve women's mortality. The ongoing Australian Longitudinal Study of Women's Health (ALSWH) shows that Australian women are getting better at reducing their smoking and alcohol use, and are generally diligent about attending recommended health screenings, but are becoming less successful at dealing with obesity. There are communities of women who live unusually healthy lives (Rosetans, Seventh-Day Adventists, traditional Japanese women), but their lifestyles are unlikely to be adopted widely. Universal Medicine (UM) is a complementary-to-medicine approach that emphasizes personal empowerment and the importance of menstrual health symptoms. This survey investigates whether the approximately 500 women associated with UM exhibit health status significantly above the norm. As part of this investigation, questions for a newly developed menstrual attitudes questionnaire will also be evaluated. A quantitative cross-sectional survey of women in a UM cohort was designed with the help of three focus groups of women at three life stages: in menses, peri-menopausal, and menopausal. The menstrual attitudes portion of the survey incorporates the insights of these women regarding female health issues. The survey also includes 41 questions taken from the ALSWH. Focus groups generated additional questions about symptoms experienced and attitudes toward female health issues. ALSWH questions, including a range of health scales like the Short Form 36 (SF-36), Center for Epidemiologic Studies Depression Scale, Perceived Control Scale, Kessler Psychological Distress Scale, and the Multi-Item Summed Score for Perceived Stress, along with questions about experienced major health events, were investigated and incorporated if considered suitable. The validity of the menstrual attitudes questionnaire will be evaluated with Cohen's kappa. ALSWH respondents and UM participants will be compared, using unweighted regression or regression weighted or normalized by age, education, and interest in alternative treatments (to increase comparability), as appropriate. Analyses will determine whether UM-related variables (being a UM participant, length of UM participation, number of UM events attended) are associated with: differences in the number of major health events and health symptoms experienced; SF-36 physical and mental health scores; body mass index; and consumption of alcohol, tobacco, sugar, salt, caffeine, and dairy. If women in the UM cohort are truly in substantially better health than the norm, further investigations may be worthwhile to see whether UM plays a causal role, and whether the women's practices are generalizable. ©Christoph Schnelle, Eunice J Minford, Vanessa McHardy, Jane Keep. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 23.11.2017.

  18. Latino Film and Video Images.

    ERIC Educational Resources Information Center

    Vazquez, Blanca, Ed.

    1990-01-01

    This theme issue of the "Centro Bulletin" examines media stereotypes of Latinos and presents examples of alternatives. "From Assimilation to Annihilation: Puerto Rican Images in U.S. Films" (R. Perez) traces the representation of Puerto Ricans from the early days of television to the films of the 1970s. "The Latino 'Boom'…

  19. Disinfection Alternatives for Small Communities in Puerto Rico

    EPA Science Inventory

    Disinfection Alternatives for Small Communities in Puerto Rico Craig Patterson1, Graciela Ramirez Toro2, Harvey Minnigh2, Cristina Maldonado3, and Rajib Sinha4 1U.S. EPA Office of Research and Development, 2Centro de Educación, Conservación e Interpretación Ambiental (CECIA),...

  20. Puerto Rican Women as Workers and Writers.

    ERIC Educational Resources Information Center

    Vazquez, Blanca, Ed.

    1989-01-01

    This theme issue of the "Centro Bulletin" highlights recent studies by and about employed Puerto Rican and Latina women. "La mujer en el Puerto Rico del siglo XIX" (O. Jimenez de Wagenheim), in Spanish, reviews the contributions of women to Puerto Rican economic, political, and social life during the nineteenth century.…

  1. Mathematical Models for Camouflage Pattern Assessment

    DTIC Science & Technology

    2013-04-01

    Matemático Facultad de Ciencias F́ısicas y Matemáticas http://www.cmm.uchile.cl DISTRIBUTION A: Distribution approved for public release University of Chile...Centro de Modelamiento Matemático Facultad de Ciencias Físicas y Matemáticas Final Report: Camouage Assessment January 2013 Abstract The main

  2. Introduction

    ERIC Educational Resources Information Center

    Nieto, Sonia; Rivera, Melissa; Quinones, Sandra; Irizarry, Jason

    2012-01-01

    The work of addressing the challenge of the education of Latinos/as has begun through, among other efforts, the National Latino/a Education Research and Policy Project (NLERAP). Beginning in 2000 as a national initiative of the Centro de Estudios Puertorriquenos at Hunter College, NLERAP's goal has been to add multiple Latino/a perspectives to the…

  3. The College Fact Book: Academic Year 2000-2001.

    ERIC Educational Resources Information Center

    El Centro Coll., Dallas, TX.

    This comprehensive fact book is part of the institutional effectiveness effort at El Centro College in Texas. It provides extensive information on students, graduation, performance measures, continuing education, faculty, and finances. Report highlights (for fall 2000, unless noted otherwise) include: (1) unduplicated headcount was 4,227; (2)…

  4. Rendezvous of the "Third Kind": Triple Helix Origins and Future Possibilities

    ERIC Educational Resources Information Center

    Etzkowitz, Henry

    2015-01-01

    The Triple Helix, representing university-industry-government interactions, was rooted in a 1993 International Workshop on University-Industry Relations at UNAM's Centro Para la Innovacion Technologica in Mexico City. Impelled by Mexican reality, where university-industry interactions and the institutions themselves operated within a governmental…

  5. Predicting Failure Initiation in Structural Adhesive Joints

    DTIC Science & Technology

    2012-08-15

    Elastoplástico de Adhesivos – Modeling, characterization and simulation of the elastoplastic behavior of adhesives. Maestría en Ciencia de Materiales...adhesive and a 1018 steel”. Maestría en Ciencia de Materiales. Centro de Investigación en Materiales Avanzados S.C. May 2012.  Abstract: In the

  6. Servicios del Centro de Soluciones Para la Energia Limpia (Spanish Translation)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    This is a Spanish translation of the Clean Energy Solutions Center fact sheet. The Solutions Center offers no-cost expert policy assistance, webinars and training forums, clean energy policy reports, data, and tools provided in partnership with more than 35 leading international and regional clean energy organizations.

  7. 77 FR 51616 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... PUNTO CERO, Kilometro 49.5 Carretera A El Salvador, Aldea El Cerinal, Barberena, Santa Rosa, Guatemala... (Guatemala) [SDNTK]. 18. GRUPO MPV, Km 14.1 Carretera El Salvador, Centro Comercial Paseo San Sebastian Local... 80617 (Guatemala) [SDNTK]. 4. ALQUILERES ROSSELL, Km 12.5 Carrertera Al Salvador, Santa Rosalia...

  8. CATIE: Tropical Agricultural Research and Higher Education Center. http://www.catie.ac.cr

    ERIC Educational Resources Information Center

    Applied Environmental Education and Communication, 2004

    2004-01-01

    This article features CATIE (Centro Agronomico Tropical de Investigacion y Ensenanza), a tropical agricultural research and higher education center. CATIE's mission is to be instrumental in poverty reduction and rural development in the American tropics, by promoting diversified and competitive agriculture and sustainable management of natural…

  9. 78 FR 47828 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... significant foreign narcotics traffickers as identified by the President. In addition, the Secretary of the..., Colonia Centro, Culiacan, Sinaloa 80000, Mexico; DOB 21 Dec 1941; POB Sinaloa, Mexico; nationality Mexico; citizen Mexico; R.F.C. NUBA411221867 (Mexico); C.U.R.P. NUBA411221HSLXDN05 (Mexico) (individual) [SDNTK...

  10. 75 FR 34214 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... organizations on a worldwide basis. It provides a statutory framework for the President to impose sanctions... traffickers as identified by the President. In addition, the Secretary of the Treasury consults with the... Italia, Michoac[aacute]n, Mexico; Calle Articulo 123 Numero 103, Colonia Centro, Nueva Italia, Michoac...

  11. Use and Analysis of Finite Element Methods for Problems of Solid Mechanics and Fracture

    DTIC Science & Technology

    1993-01-19

    improve global accuracy and convergence rates, specific activities such as mesh refinement may be undertaken local to the crack tips. A criticism ...Sciences, Centro Internacional de Metodos Numnericos en Ingenieria, Barcelona, 1992 11 1 |l!avacek, J Rosenberg, A E Beagles and J R Whiteman

  12. Thromboembolic Complications in Thermally Injured Patients,

    DTIC Science & Technology

    1992-12-01

    profilaxis con brdld vanec entre 0.4% et 7%. La signification cliniquc de ces heparina, militan en contra de su uso rutinario, excepto en Ev~nements est...centros adopten rutinariamente la profilaxis 8. Purdue, G.F., Hunt, J.L.: Pulmonary emboli in burned patients. J. con heparina de baja dosificaci6n. Se

  13. [Ancient disease, but not a thing of the past: Pott's paraplegia in an HIV-positive health-care worker].

    PubMed

    Jurado, Leonardo F

    2017-04-01

    Centro de Investigación UNINAVARRA-CINA, Fundación Universitaria Navarra, Neiva, ColombiaGrupo de Investigación MICOBAC-UN, Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia.

  14. U.S. Drug Policy: Shaping Relations With Latin America

    DTIC Science & Technology

    2014-06-01

    107  Table 4.  World economy rankings...Table 6.  World import / export rankings ......................................................................114  Table 7.  U.S. 2011 and intentional...CentroAmericanos UN United Nations UNODC United Nations Office on Drugs and Crime U.S. United States WHO World Health Organization xv ACKNOWLEDGMENTS

  15. Hypermethylation of AP-2Alpha as a Prognostic Marker for DCIS

    DTIC Science & Technology

    2008-05-01

    Unfortunately, among the methylation status of the AP2, CYCLIN D, ECAD , GSTP, and SSOCS genes, either as individual genes, or in combinations, no...0.61 to 4.10) 1.00 (referent) 0.35 ECAD M UM 0 100 3 97 GSTP M UM 40 60 24 76 2.02 (0.72 to 5.64) 1.00...Missing data: 1.4% for AP2, CYCLIN D, ECAD , GSTP; 4.2% for SSOCS; 2.8% for nuclear grade. §M=methylated; UM=unmethylated; +Two-sided

  16. Attache Extraordinaire: Vernon A. Walters and Brazil

    DTIC Science & Technology

    2009-03-01

    contudo, o primeiro encontro com um brasileiro. De acordo com uma entrevista que Walters concedeu, em 1966, ao Jornal O Globo, o primeiro brasileiro...21 de fevereiro de 1964, às 18 h, Lincoln Gordon enviou um telegrama ao Departamento de Estado. A mensagem dava conta de um encontro que o...disposição de Goulart em assumir riscos extremos, por meio do incentivo a violência esporádica no interior, encontros de grandes multidões e greves com o

  17. Development of a universal metabolome-standard method for long-term LC-MS metabolome profiling and its application for bladder cancer urine-metabolite-biomarker discovery.

    PubMed

    Peng, Jun; Chen, Yi-Ting; Chen, Chien-Lun; Li, Liang

    2014-07-01

    Large-scale metabolomics study requires a quantitative method to generate metabolome data over an extended period with high technical reproducibility. We report a universal metabolome-standard (UMS) method, in conjunction with chemical isotope labeling liquid chromatography-mass spectrometry (LC-MS), to provide long-term analytical reproducibility and facilitate metabolome comparison among different data sets. In this method, UMS of a specific type of sample labeled by an isotope reagent is prepared a priori. The UMS is spiked into any individual samples labeled by another form of the isotope reagent in a metabolomics study. The resultant mixture is analyzed by LC-MS to provide relative quantification of the individual sample metabolome to UMS. UMS is independent of a study undertaking as well as the time of analysis and useful for profiling the same type of samples in multiple studies. In this work, the UMS method was developed and applied for a urine metabolomics study of bladder cancer. UMS of human urine was prepared by (13)C2-dansyl labeling of a pooled sample from 20 healthy individuals. This method was first used to profile the discovery samples to generate a list of putative biomarkers potentially useful for bladder cancer detection and then used to analyze the verification samples about one year later. Within the discovery sample set, three-month technical reproducibility was examined using a quality control sample and found a mean CV of 13.9% and median CV of 9.4% for all the quantified metabolites. Statistical analysis of the urine metabolome data showed a clear separation between the bladder cancer group and the control group from the discovery samples, which was confirmed by the verification samples. Receiver operating characteristic (ROC) test showed that the area under the curve (AUC) was 0.956 in the discovery data set and 0.935 in the verification data set. These results demonstrated the utility of the UMS method for long-term metabolomics and discovering potential metabolite biomarkers for diagnosis of bladder cancer.

  18. PREFACE: Third Congress on Materials Science and Engineering (CNCIM-Mexico 2012)

    NASA Astrophysics Data System (ADS)

    de Coss, Romeo; Murrieta-Hernández, Gabriel; Aguayo-González, Aarón; Rubio-Rosas, Efraín; Chigo-Anota, Ernesto; Vigueras-Santiago, Enrique

    2013-06-01

    The Third Congress on Material Science and Engineering (CNCIM-México 2012), which took place in Mérida, México, from 27 February to 2 March 2012 was organized by three research groups (cuerpos académicos) from the Universidad Autónoma de Yucatán: Ingeniería Física (UADY-CA-27), Modelado y Simulación Computacional de Sistemas Físicos (UADY-CA-101) and Química Fundamental y Aplicada (UADY-CA-32), in collaboration with the Centro de Investigación y de Estudios Avanzados (Cinvestav-Mérida). The First Congress in Material Science and Engineering (CNCIM-2010), was organized in Puebla, México in February 2010. This was followed by CNCIM-2011 held in Toluca, México in February 2011. The CNCIM-México 2012 Conference consisted of plenary talks (8), invited talks (10), oral contributions (54) and poster presentations (70). The topics of the Conference were: Synthesis and Preparation of Materials: Organic and Inorganic Characterization of Materials: Novel Methods and Techniques Applications of Materials: Environment, Medicine, Pharmacy, Technology, Food and Renewable Energy New Materials: Composites, Nanostructures, and from Natural Sources Theory: New Methods and Computer Simulations We want to thank the Organizing Committee, the Institutions and Sponsors supporting the Conference, and everyone who contributed to the organization of this meeting, for their invaluable efforts in order to guarantee the complete success of this conference. Editors Romeo de Coss Centro de Investigación y de Estudios Avanzados del I.P.N. (Cinvestav-Mérida) A.P. 73 Cordemex 97310, Mérida, Yucatán, México decoss@mda.cinvestav.mx Gabriel Murrieta-Hernández Universidad Autónoma de Yucatán Calle 60 No. 491-A, Centro Histórico, C.P. 97000, Mérida, Yucatán, México murrieta@uady.mx Aarón Aguayo-González Universidad Autónoma de Yucatán Calle 60 No. 491-A, Centro Histórico, C.P. 97000, Mérida, Yucatán, México aguayo@uady.mx Efraín Rubio-Rosas Benemérita Universidad Autónoma de Puebla Ciudad Universitaria, Col. San Manuel, C.P. 72570, Puebla, Puebla, México efrain.rubio@cuv.buap.mx Ernesto Chigo-Anota Benemérita Universidad Autónoma de Puebla Ciudad Universitaria, Col. San Manuel, C.P. 72570, Puebla, Puebla, México ernesto.chigo@correo.buap.mx Enrique Vigueras-Santiago Universidad Autónoma del Estado de México Instituto Literario No. 100, Col. Centro 50000, Toluca, Edo. de México, México vigueras@uaemex.mx Session Chairs Gabriel Canto Santana, Universidad Autónoma de Campeche. Enrique Vigueras Santiago, Universidad Autónoma del Estado de México. César Cab, Universidad Autónoma de Yucatán. Alejandro ávila Ortega, Universidad Autónoma de Yucatán. Jesús Barrón Zambrano, Universidad Autónoma de Yucatán. Maritza de Coss, Universidad Autónoma de Yucatán. Jorge A. Tapia González, Universidad Autónoma de Yucatán. David Muñoz Rodríguez, Universidad Autónoma de Yucatán. Mario Pérez Cortes, Universidad Autónoma de Yucatán. Jesús García Serrano, Universidad Autónoma del Estado de Hidalgo. Rubén Arturo Medina Esquivel, Universidad Autónoma de Yucatán. César R. Acosta, Universidad Autónoma de Yucatán. Organizing Committee Aarón Aguayo González, Universidad Autónoma de Yucatán. Gabriel Murrieta Hernández, Universidad Autónoma de Yucatán. Alejandro Tapia González, Universidad Autónoma de Yucatán. Cristian Carrera Figueiras, Universidad Autónoma de Yucatán. Heriberto Hernández Cocoletzi, Benemérita Universidad Autónoma de Puebla. Ernesto Chigo Anota, Benemérita Universidad Autónoma de Puebla. Efraín Rubio Rosas, Benemérita Universidad Autónoma de Puebla. Enrique Vigueras Santiago, Universidad Autónoma del Estado de México. Romeo de Coss, Centro de Investigación y de Estudios Avanzados (Cinvestav-Mérida). Organizers: Organizers Sponsors: Sponsors

  19. In vivo monitoring of nanosphere onsite delivery using fiber optic microprobe

    NASA Astrophysics Data System (ADS)

    Lo, Leu-Wei; Yang, Chung-Shi

    2005-02-01

    To recognize the information of ischemia-induced blood vessel permeability would be valuable to formulate the drugs for optimal local delivery, we constructed an implantable needle type fiber-optic microprobe for the monitoring of in vivo fluorescent substances in anesthetized rats. This fiber-optic microprobe was composed of coaxial optical fibers and catheterized using a thin wall tubing of stainless steel (~400 um O.D. and ~300 um I.D.). The central fiber, with 100 um core diameter and 20 um cladding, coated with a 30 um layer of gold, was surrounded by 10 fibers with 50 um cores. The central fiber carried the light from the 488 nm Argon laser to the tissue while the surrounding fibers collected the emitted fluorescence to the detector. When the fiber-optic microprobe was placed in the solutions containing various concentrations of fluorescent nanospheres (20 nm), either with or without 10% lipofundin as optical phantom, nanosphere concentration-dependent responses of the fluorescence intensity were observed. The microprobe was then implanted into the liver and the brain of anesthetized rats to monitor the in situ extravasation of pre-administered fluorescent nanospheres from vasculature following the ischemic insults. Both the hepatic and cerebral ischemic insults showed immediate increases of the extracellular 20 nm fluorescent nanospheres. The implantable fiber-optic microprobe constructed in present study provides itself as a minimally-invasive technique capable of investigating the vascular permeability for in vivo nanosphere delivery in both ischemic liver and brain.

  20. Targeted sections in either XY or XZ plane with dual-axes confocal endomicroscope (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Li, Gaoming; Li, Haijun; Duan, Xiyu; Zhou, Quan; Zhou, Juan; Oldham, Kenn R.; Wang, Thomas D.

    2017-02-01

    We demonstrate a dual axes confocal architecture, which can be used to collect horizontal(XY-plane) or vertical cross-sectional(XZ-plane) images for tissue. This scanner head is 5.5mm in outer diameter(OD), and integrates a 3D MEMS scanner with a compact chip size of 3.2×2.9mm2. To realize the miniaturization, there are some obstacles of the small size of 3D MEMS scanner, MEMS wire bundle, the air pressure effect for MEMS motion, the processing of parabolic mirror, and optical alignment to come over. In our probe, separation mechanical structure for optical alignment was adopted and a step shape MEMS holder was designed to deal with the difficult of MEMS wire bundle. Peptides have been demonstrated tremendous potential for in vivo use to detect colonic dysplasia. This class of in vivo molecular probe can be labeled with near-infrared (NIR) dyes for visualizing the full depth of the epithelium in small animals. To confirm our probe performance, we take use of USAF 1951 resolution target to test its lateral and axial resolution. It has lateral and axial resolution of 2.49um and 4.98um, respectively. When we collect the fluorescence imaging of colon, it shows that the field of view are 1000um×1000um (horizontal) and 1000um×430um (vertical). The horizontal and vertical cross-sectional images of fresh mouse colonic mucosa demonstrate imaging performance with this miniature instrument.

  1. Waves of the Future (for Mars): In-Situ Mid-infrared, Near-infrared, and Visible Spectroscopic Analysis of Antarctic Cryptoendolithic Communities.

    NASA Astrophysics Data System (ADS)

    Hand, K. P.; Calrson, R.; Sun, H.; Anderson, M.; Wynn, W.; Levy, R.

    2005-12-01

    We have analyzed both the surface expression and depth profile of cryptoendolithic microbial communities at Battleship Promontory, in the Dry Valleys of Antarctica. Data was collected on site with an active mid-infrared Fourier transform microspectrometer (2.6 - 15 um), a near-infrared spectrometer (0.9-1.8 um), and a visible spectrometer (0.4-1 um). The trio of instruments are connected to microscopes that yield ~1 mm2 spatial resolution on the sample and they are mounted on two perpendicular motorized stages that allow for spatial scanning over an area of ~2cm2. Here we present results on the surface expression of the subsurface microbes in these three spectral regions and we present results on the analysis of a colonized sample examined in cross section. The former case has direct application to the remote, robotic detection of life within the rocks of Mars and the later case provides fundamental insights into the geological and biological interactions that make the Antarctic cryptoendolithic ecosystems possible. Non-invasive surface detection of cyanobacterial dominated communities was possible through the observation of several distinct bands: the carbon-hydrogen stretching modes (symmetric and asymmetric) for CH, CH2, and CH3 in the regions of 3.3-3.6 um and 3.6-3.7 um; the NH2 scissoring and C=O stretch near 6.0 um; the amide I of beta-pleated structures at ~6.1 um; and the 6.4 um - 6.6 um bands of N-H in plane bend of the amide II functional group. In combination, these bands make a strong case for carbohydrates and proteins associated with life. Not surprisingly, as the integrity of the amorphous silica surface varnish improved, our ability to detected the subsurface biosignature decreased. We note, however, that by utilizing the JPL rock crusher in Antarctica, a device designed to fly on the Mars Science Laboratory mission, the mid-infrared biosignature was easily detected. In the cross-section analysis the mid-infrared data provide a depth profile tracking the presence of hydrocarbons, amide bonds, and the mineralogical transition from amorphous quartz to crystalline sandstone. Mapped onto this are the changes in the oxidation states of iron, as recorded by the visible and near-infrared spectrometers. Together, this data set allows us to track the role of biologically produced compounds, such as oxalic acid, in the chelation and leaching of iron compounds from the surface through the rock and into the deposition zone below the colonized subsurface region.

  2. Evaluation of Reference Centers for Special Immunobiologicals implementation.

    PubMed

    Nóbrega, Laura Andrade Lagôa; Novaes, Hillegonda Maria Dutilh; Sartori, Ana Marli Christovam

    2016-09-01

    To describe the Reference Centers for Special Immunobiologicals and evaluate their implementation considering formal regulations. We conducted a program evaluation, of evaluative research type. From August 2011 to January 2012, a questionnaire was applied to the 42 Reference Centers for Special Immunobiologicals existing in the Country, approaching the structure, human resources, and developed activities dimensions. We conducted a descriptive analysis of data and used a clustering for binary data with the squared Euclidean distance, by the farthest neighbor method, to aggregate services with similar features. We observed great diversity among the services in the three dimensions. The clustering resulted in five service profiles, named according to their characteristics. 1) Best structure: 12 Reference Centers for Special Immunobiologicals with the highest proportion of services with the minimum of rooms recommended, purpose-built vaccine refrigerators, preventive maintenance of the cold chain, and oxygen source. 2) Immunobiologicals distributor: six Reference Centers for Special Immunobiologicals that distributed more than applied immunogens; no doctor present for more than half of the working hours and no purpose-built vaccine refrigerators . 3) Incipient implementation: five Reference Centers for Special Immunobiologicals with inadequate structure, such as absence of purpose-built vaccine refrigerators, preventive maintenance of the cold chain and oxygen source; none had computer. 4) Vaccination rooms: 13 Reference Centers for Special Immunobiologicals, everyone did routine immunization, most participated in vaccination campaigns. 5) Teaching and research: six services, all inserted into teaching hospitals, developed researches and received trainees; most had doctors in more than half of the working hours. The evaluation of the Reference Centers for Special Immunobiologicals implementation was based on the profiles found and considered the official regulations: services categorized as "better structure" and "teaching and research" were considered implemented; "immunobiologicals distributor" and "vaccination room" services, partially implemented, and the ones with the "incipient implementation" profile, not implemented. The results of this evaluation can contribute to the reformulation of the services, considering the current context. Descrever os Centros de Referência para Imunobiológicos Especiais e avaliar sua implantação considerando as regulamentações formais. Foi realizada uma avaliação de programa, tipo pesquisa avaliativa. De agosto de 2011 a janeiro de 2012, foi aplicado questionário aos responsáveis pelos 42 Centros de Referência para Imunobiológicos Especiais existentes no País, abordando as dimensões estrutura, recursos humanos e atividades desenvolvidas. Foi feita análise descritiva dos dados e utilizado agrupamento para dados binários com uso da distância euclidiana quadrática, pelo método do vizinho mais distante, para agregar serviços com características semelhantes. Observou-se grande diversidade entre os serviços nas três dimensões. O agrupamento resultou em cinco perfis de serviços, denominados de acordo com suas características. 1) Melhor estrutura: 12 Centros de Referência para Imunobiológicos Especiais com a maior proporção de serviços com o mínimo de salas preconizado, câmaras de vacinas, manutenção preventiva da rede de frio e fonte de oxigênio. 2) Dispensador de imunobiológicos: seis Centros de Referência para Imunobiológicos Especiais que mais dispensavam do que aplicavam imunógenos; sem médico presente por mais da metade do expediente do serviço e sem câmara de vacinas. 3) Implantação incipiente: cinco Centros de Referência para Imunobiológicos Especiais com estrutura inadequada, como ausência de câmaras de vacinas, de manutenção preventiva da rede de frio e de fonte de oxigênio; nenhum possuía computador. 4) Sala de vacinas: 13 Centros de Referência para Imunobiológicos Especiais, todos faziam imunização de rotina, a maioria participava de campanhas de vacinação. 5) Ensino e pesquisa: seis serviços, todos inseridos em hospitais de ensino, desenvolviam pesquisas e recebiam estagiários; a maioria possuía médicos em mais da metade do expediente. A avaliação de implantação dos Centros de Referência para Imunobiológicos Especiais baseou-se nos perfis encontrados e considerou as regulamentações oficiais: os serviços categorizados como "melhor estrutura" e "ensino e pesquisa" foram considerados implantados; os serviços "dispensador de imunobiológicos" e "sala de vacinas", parcialmente implantados e os do perfil "implantação incipiente", não implantados. Os resultados dessa avaliação podem contribuir para a reformulação dos serviços, considerando o contexto atual.

  3. VizieR Online Data Catalog: 70um-1.2mm and N2H+ maps of IRDC18454 (W43) (Beuther+,

    NASA Astrophysics Data System (ADS)

    Beuther, H.; Tackenberg, J.; Linz, H.; Henning, T.; Krause, O.; Ragan, S.; Nielbock, M.; Launhardt, R.; Schmiedeke, A.; Schuller, F.; Carlhoff, P.; Nguyen-Luong, Q.; Sakai, T.

    2011-11-01

    The cloud complex with a size of ~6'x6' was observed with PACS on Herschel on 2010 March 9. Maps at 250, 350, and 500um were obtained with SPIRE 2010) on 2010 March 11. We observed IRDC18454-1 with the Plateau de Bure Interferometer during five nights in October and November 2009 at 93GHz in the C and D configurations. The N2H+ data has been observed using the BEARS receiver at the NRO 45m telescope in Nobeyama, Japan. The different velocity components have been observed one in April 2010 with an average system temperature of Tsys=206K, the second in June, at slightly lower Tsys. The MIPS 24um data (from MIPSGAL) as well as the IRAC 8um observations (from GLIMPSE) are taken from the Spitzer archive. The 1.2mm continuum data were first presented in Beuther et al. (2002, Cat. J/ApJ/566/945) and the APEX 870um data are part of the ATLASGAL survey of the Galactic plane (Schuller et al., 2009A&A...504..415S). (2 data files).

  4. Heterologous production and characterization of a chlorogenic acid esterase from Ustilago maydis with a potential use in baking.

    PubMed

    Nieter, Annabel; Kelle, Sebastian; Takenberg, Meike; Linke, Diana; Bunzel, Mirko; Popper, Lutz; Berger, Ralf G

    2016-10-15

    Ustilago maydis, an edible mushroom growing on maize (Zea mays), is consumed as the food delicacy huitlacoche in Mexico. A chlorogenic acid esterase from this basidiomycete was expressed in good yields cultivating the heterologous host Pichia pastoris on the 5L bioreactor scale (reUmChlE; 45.9UL(-1)). In contrast to previously described chlorogenic acid esterases, the reUmChlE was also active towards feruloylated saccharides. The enzyme preferred substrates with the ferulic acid esterified to the O-5 position of arabinose residues, typical of graminaceous monocots, over the O-2 position of arabinose or the O-6 position of galactose residues. Determination of kcat/Km showed that the reUmChlE hydrolyzed chlorogenic acid 18-fold more efficiently than methyl ferulate, p-coumarate or caffeate. Phenolic acids were released by reUmChlE from natural substrates, such as destarched wheat bran, sugar beet pectin and coffee pulp. Treatment of wheat dough using reUmChlE resulted in a noticeable softening indicating a potential application of the enzyme in bakery and confectionery. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. 3D brain oxygenation measurements in awake hypertensive mice using two photon phosphorescence lifetime imaging

    NASA Astrophysics Data System (ADS)

    Lu, Xuecong; Moeini, Mohammad; Li, Baoqiang; Zhang, Cong; Sakadžić, Sava; Lesage, Frédéric

    2018-02-01

    Cardiovascular risk factors, such as hypertension, have been associated with cognitive decline, potentially due to their impact on brain tissue oxygenation. In this study, high spatial resolution imaging in three dimensions was used to understand changes in brain oxygenation with hypertension. Experiments were performed on Young (WT_Y, 3-4 months, n=8), Old (WT_O, 6-7 months, n=8), and Old with hypertension (HP_O, 6-7 months, n=8) C57bL/6 awake mice. Two photon phosphorescence lifetime microscopy using an O2-sensitive phosphorescent dye PtPC343 was employed to measure two dimensional grids of PO2 in capillary beds (400um*400um, 25*25 pixels, acquired in 4 mins) and decays from arterioles. Scans were obtained continuously at depths from 50 um to 300 um under the brain surface. Using 3D measurements and a 250 um depth stack, we removed the compounding effects on brain oxygenation diffusion from surrounding brain vessels. The entire measurement of each vasculature stack required less than 30 minutes. This study indicates that among vascular risk factors, hypertension can reduce oxygen delivery and could potentially contribute to cognition decline.

  6. Spitzer/IRS spectroscopy of the 12um Seyferts

    NASA Astrophysics Data System (ADS)

    Wu, Yanling; Charmandaris, V.; Huang, J.; Houck, J.

    2009-01-01

    The extended 12um galaxy sample is a flux-limited sample of 893 galaxies selected from the IRAS Faint Source Catalog 2. A total of 118 objects from this sample have been classified optically as Seyfert galaxies, providing one of the largest infrared selected unbiased sample of active galactic nuclei (AGN). We present our prelimary results from our analysis of mid-infrared Spitzer/IRS spectra of 102 12um Seyferts (that is 86 % of the 12um Seyfert sample) which have been observed by various Spitzer programs and are available in the Spitzer archive. A number of mid-infared diagnostics have been developed to study the nature of nuclear dust enshrouded emission from AGNs, in order to disentangle the starburst-AGN connection. Since PAH emission is a tracer of star formation activity we have measured the 11.3um PAH feature for our Seyfert sample. We find that as the strength of the radiation field in AGNs increases the PAH molecules are destroyed, while the PAH EWs increase with the IRAS f60/f25 ratios of the host galaxies. We further probe this warm/cold color diagnostic, by contrasting our findings with those of we starbust galaxies, ULIRGs, as well as blue compact dwarf galaxies.

  7. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study

    PubMed Central

    Gonzales, Isidro; Miranda, J Jaime; Rodriguez, Silvia; Vargas, Victor; Cjuno, Alfredo; Smeeth, Liam; Gonzalez, Armando E; Tsang, Victor C W; Gilman, Robert H; Garcia, Hector H

    2015-01-01

    Objectives To examine the prevalence of seizures, epilepsy and seropositivity to cysticercosis in rural villagers (cysticercosis-endemic setting), rural-to-urban migrants into a non-endemic urban shanty town and urban inhabitants of the same non-endemic shanty town. Methods Three Peruvian populations (n = 985) originally recruited into a study about chronic diseases and migration were studied. These groups included rural inhabitants from an endemic region (n = 200), long-term rural-to-urban migrants (n = 589) and individuals living in the same urban setting (n = 196). Seizure disorders were detected by a survey, and a neurologist examined positive respondents. Serum samples from 981/985 individuals were processed for cysticercosis antibodies on immunoblot. Results Epilepsy prevalence (per 1000 people) was 15.3 in the urban group, 35.6 in migrants and 25 in rural inhabitants. A gradient in cysticercosis antibody seroprevalence was observed: urban 2%, migrant 13.5% and rural group 18% (P < 0.05). A similarly increasing pattern of higher seroprevalence was observed among migrants by age at migration. In rural villagers, there was strong evidence of an association between positive serology and having seizures (P = 0.011) but such an association was not observed in long-term migrants or in urban residents. In the entire study population, compared with seronegative participants, those with strong antibody reactions (≥ 4 antibody bands) were more likely to have epilepsy (P < 0.001). Conclusions It is not only international migration that affects cysticercosis endemicity; internal migration can also affect patterns of endemicity within an endemic country. The neurological consequences of cysticercosis infection likely outlast the antibody response for years after rural-to-urban migration. Objectifs Examiner la prévalence des crises d’épilepsie, de l’épilepsie et de la séropositivité à la cysticercose chez les villageois des zones rurales (cadre endémique pour la cysticercose), chez les migrants des zones ruraux vers les zones urbaines dans un bidonville urbain non endémique et chez les habitants urbains du même bidonville non endémique. Méthodes Trois populations péruviennes (n = 985) recrutées initialement dans une étude sur les maladies chroniques et la migration, ont été étudiées. Ces groupes comprenaient des habitants de zones rurales d'une région d'endémie (n = 200), des migrants de long terme de zones ruraux vers les villes (n = 589) et les personnes vivant dans le même milieu urbain (n = 196). Les troubles épileptiques ont été détectés par un sondage et un neurologue a examiné les répondants positifs. Des échantillons de sérum de 981/985 individus ont été testés pour les anticorps de cysticercose par Immunoblot. Résultats La prévalence de l’épilepsie (pour 1000 personnes) était de 15,3 dans le groupe urbain; 35,6 chez les migrants et 25 dans la population rurale. Un gradient dans la séroprévalence des anticorps de la cysticercose a été observé: dans le groupe urbain 2%, le groupe de migrants 13,5% et le groupe rural 18% (p <0,05). Une tendance croissante similaire de séroprévalence plus élevée a été observée chez les migrants selon l’âge à la migration. Chez les villageois ruraux, il y avait des preuves solides d'une association entre une sérologie positive et le fait d'avoir des crises (p = 0,011), mais une telle association n'a pas été observée chez les migrants de long terme ou chez les résidents urbains. Dans l'ensemble de la population de l’étude, ceux avec de fortes réactions d'anticorps (≥ 4 bandes d'anticorps) étaient plus susceptibles d'avoir l’épilepsie (p <0,001) comparé aux participants séronégatifs. Conclusions La migration internationale n'est pas la seule qui affecte l'endémicité de la cysticercose; la migration interne peut aussi modifier les profils d'endémicité au sein d'un même pays d'endémie. Les conséquences neurologiques de l'infection par la cysticercose sont susceptibles de survivre à la réponse d'anticorps durant des années après la migration des zones rurales vers les zones urbaines. Objetivos Examinar la prevalencia de convulsiones, epilepsia, y seropositividad para cisticercosis entre población rural (de zonas endémicas para cisticercosis), inmigrantes provenientes de zonas rurales a tugurios urbanos no endémicos, y habitantes urbanos de los mismo tugurios urbanos no endémicos. Métodos Se estudiaron tres poblaciones peruanas (n=985) originalmente reclutadas en un estudio de enfermedades crónicas y migración. Estos grupos incluían habitantes rurales de una región endémica (n=200), inmigrantes de larga duración de zonas rurales a urbanas (n=589), e individuos que vivían en la misma zona urbana (n=196). Las convulsiones se detectaron mediante una encuesta y un neurólogo examinó a quienes habían respondido positivamente. Se procesaron muestras de suero de 981/985 individuos en busca de anticuerpos para cisticercosis mediante inmunoblot. Resultados La prevalencia de epilepsia (por 1,000 personas) era de 15.3 en el grupo urbano, 35.6 en inmigrantes y 25 en habitantes rurales. Se observó un gradiente en la seroprevalencia de los anticuerpos para cisticercosis: grupos urbano 2%, inmigrante 13.5% y rural 18% (p<0.05). Se observó un patrón de aumento similar de mayor seroprevalencia entre inmigrantes según la edad que tenían en el momento de emigrar. En pobladores rurales, había una evidencia importante de asociación entre tener una serología positiva y sufrir convulsiones (p=0.011), pero esta asociación no se observaba en inmigrantes de larga duración o residentes urbanos. En la población al completo, comparada con los participantes seronegativos, aquellos con una fuerte reactividad de anticuerpos (≥4 bandas de anticuerpos) tenían una mayor probabilidad de sufrir epilepsia (p<0.001). Conclusiones No solo la migración internacional afecta la endemicidad de cisticercosis; la migración interna también puede afectar los patrones de endemicidad dentro de un país endémico. Las consecuencias neurológicas de la infección por cisticercos podrían durar más que la respuesta a anticuerpos años después de la migración de zonas rurales a zonas urbanas. PMID:25581851

  8. (QC Themes) Type-Two Quantum Computing in PBG-Based Cavities for Efficient Simulation of Lattice Gas Dynamics

    DTIC Science & Technology

    2008-04-26

    substrate Si3N4 Diameter : 540 nm Pitch : 760 nm Diamond Holes in Diamond (HID) Pillars of Diamond (POD) POD with Electrooptic Polymer at Center 3D ...Diamond film : 2 um Si- substrate Al : 0.2 um PMMA : 0.5um 1. Deposit UNCD film 2. Deposit Al metal 3. Deposit PMMA on Al 4. E-beam Lithography 5...band-gap (PBG) based cavities. The cavities are etched directly on to the diamond substrate . The set of coupled qubits in each spot represents an

  9. Direct hip joint distraction during acetabular fracture surgery using the AO universal manipulator.

    PubMed

    Calafi, L Afshin; Routt, M L Chip

    2010-02-01

    Certain acetabular fractures may necessitate distraction of the hip joint for removal of intra-articular debris and assessment of reduction. Distraction can be accomplished by manual traction, using a traction table or an AO universal manipulator (UM). The UM is a relatively simple and an inexpensive device that can provide focal distraction in a controlled manner without the risks associated with the use of a traction table. We describe a technique using the UM for hip joint distraction during acetabular fracture surgery through a Kocher-Langenbeck surgical exposure.

  10. PERSONALITY TRAITS AND STRESS LEVELS AMONG SENIOR DENTAL STUDENTS: EVIDENCE FROM MALAYSIA AND SINGAPORE.

    PubMed

    Yusof, Zamros Y M; Hassan, Wan Nurazreena Wan; Razak, Ishak A; Hashim, Siti Marini N; Tahir, Mohd Khairul A M; Keng, Siong Beng

    2016-11-01

    This study aimed to evaluate the association between dental students’ personality traits and stress levels in relation to dental education programs among senior dental students in University Malaya (UM) in Malaysia and National University of Singapore (NUS). A cross-sectional survey using a self-administered questionnaire was conducted on UM and NUS senior dental students. The questionnaire comprised items on demographic background, the Big Five Inventory Personality Traits (BFIPT) test and a modified Dental Environment Stress (DES) scale. Rasch analysis was used to convert raw data to interval scores. Analyses were done by t-test, Pearson correlation, and Hierarchical regression statistics. The response rate was 100% (UM=132, NUS=76). Personality trait Agreeableness (mean=0.30) was significantly more prevalent among UM than NUS students (mean=0.15, p=0.016). In NUS, Neuroticism (mean=0.36) was significantly more prevalent than in UM (mean=0.14, p=0.002). The DES mean score was higher among NUS (mean=0.23) than UM students (mean=0.07). In UM, Neuroticism was significantly correlated with stress levels (r=0.338, p<0.001). In NUS, these were Neuroticism (r=0.278, p=0.015), Agreeableness (r=0.250, p=0.029) and Conscientiousness (r=-0.242, p=0.035) personality traits. The correlation was strongest for personality trait Neuroticism in both schools. Hierarchical regression analysis showed that gender and Neuroticism were significant predictors for students’ stress levels (p<0.05) with the latter exerting a bigger effect size (R2=0.18) than gender (R2=004). This study showed that gender and Neuroticism personality trait were significant predictors for stress levels among selected groups of dental students in Southeast Asia. Information on students’ personality may be useful in new students’ intake, stress management counseling and future program reviews.

  11. Development of an In-line Urine Monitoring System for the International Space Station

    NASA Technical Reports Server (NTRS)

    Broyan, James Lee, Jr.; Cibuzar, Branelle R.

    2009-01-01

    Exposure to microgravity during space flight causes bone loss when calcium and other metabolic by-products are excreted in urine voids. Frequent and accurate measurement of urine void volume and constituents is thus essential in determining crew bone loss and the effectiveness of the countermeasures that are taken to minimize this loss. Earlier space shuttle Urine Monitoring System (UMS) technology was unable to accurately measure urine void volumes due to the cross-contamination that took place between users, as well as to fluid system instabilities. Crew urine voids are currently collected manually in a flexible plastic bag that contains a known tracer quantity. A crew member must completely mix the contents of this bag before withdrawing a representative syringe sample for later ground analysis. The existing bag system accuracy is therefore highly dependent on mixing technique. The International Space Station (ISS) UMS has been developed as an automated device that collects urine from the Waste and Hygiene Compartment (WHC) urinal funnel interface, separates the urine, measures void volume, and allows for syringe sampling. After the ISS UMS has been used by a crew member, it delivers urine to the WHC for normal processing. The UMS plumbing is then flushed with a small volume of water. The current ISS UMS design incorporates an innovative rotary separator that minimizes foaming, consequently greatly reducing cross-contamination among urine voids (less than 0.5 mL urine) while also providing accurate volume measurements (less than 2 percent error for 100 to 1,000 mL void volumes). ISS UMS performance has been validated through extensive ground tests and reduced-gravity aircraft flights. The locker-sized ISS UMS is currently undergoing a design modification that will permit it to interface with the ISS Node 3 WHC Russian toilet (ACY) hardware. The operating principles, characteristics, and results of this design modification are outlined here.

  12. An indirect continuous running multistage field test: the Université de Montréal track test.

    PubMed

    Léger, L; Boucher, R

    1980-06-01

    The object of this study was to report on the validity and reliability of the Université de Montréal Track Test (UM-TT). The UM-TT is a continuous maximal indirect multistage running field test based on the energy cost of running. The first stage is set at a walking speed that requires 5 Mets; thereafter the speed is increased by 1 Met every two minutes. In order to assess the validity of the UM-TT, 25 subjects, 24.4 +/- 2.8 years old (X +/- SD) had their VO2max predicted with the UM-TT and measured directly with a running multistage treadmill test. Averages (+/- SD) were not significantly different (61.5 +/- 10.6 and 61.4 +/- 10.9 ml O2 . kg-1 . min-1, respectively), other statistics being r = 0.96, delta = 0.09 +/- 2.90 ml O2 . kg-1 . min-1 and Syx = 2.81 ml O2 . kg-1 . min-1. Seven males, 20.6 +/- 1.0 years old, had also their VO2max measured directly during the UM-TT. Comparison of predicted and directly measured VO2max yielded similar results: 70.0 +/- 4.5 and 70.7 +/- 6.0 ml O2 . kg-1 . min-1, respectively with r = 0.66, delta = 0.67 +/- 4.53 and Syx = 3.71. Reliability of the UM-TT was assessed by repeating the test twice on 60 subjects (49 males and 11 females; 39 subjects below 30 years old and 21, above; and 30 subjects below and above 15 Mets). Results were as follows: X +/- SD = 54.1 +/- 8.2 and 54.2 +/- 8.5, r = 0.97, delta 0.11 +/- 1.92, and Syx = 1.92. Similar reliability trends were observed for each one of the subgroups of subjects. It is concluded that the UM-TT is valid and reliable to estimate the VO2max of trained and untrained young and middle-age males and females.

  13. Long-Term Satisfaction and Body Image After Contralateral Prophylactic Mastectomy

    PubMed Central

    Anderson, Chelsea; Islam, Jessica Y.; Hodgson, M. Elizabeth; Sabatino, Susan A.; Rodriguez, Juan L.; Lee, Clara N.; Sandler, Dale P.; Nichols, Hazel B.

    2017-01-01

    Background Contralateral prophylactic mastectomy (CPM) rates have been increasing in the U.S. Though some studies have reported high overall satisfaction among women who undergo CPM, it is unclear how long-term satisfaction differs from that of women who undergo unilateral mastectomy (UM). Furthermore, few studies have assessed whether the effects of CPM on body image differ from those of breast conserving surgery (BCS) or UM. Methods We analyzed responses from a survey of women with both a personal and family history of breast cancer who were enrolled in the Sister Study (n=1176). Among women who underwent mastectomy, satisfaction with mastectomy decision and reconstruction was compared between women who underwent CPM and UM. We also evaluated responses on 5 items related to body image according to surgery type (BCS, UM without reconstruction, CPM without reconstruction, UM with reconstruction, and CPM with reconstruction). Results Participants were, on average, 60.8 years old at diagnosis (SD=8.7) and 3.6 years post-diagnosis at the time of survey (SD=1.7). BCS was the most common surgical treatment reported (63%), followed by CPM (22%) and UM (15%). Satisfaction with mastectomy decision was reported by 97% of women who underwent CPM and 89% of those who underwent UM. Compared to other surgery types, women who underwent CPM without reconstruction reported feeling more self-conscious, less feminine, less whole, and less satisfied with the appearance of their breasts. Body image was consistently highest among women who underwent BCS. Conclusions In our sample of women with both a personal and family history of breast cancer, most were highly satisfied with their mastectomy decision, including those who elected to undergo CPM. However, body image was lowest among women who underwent CPM without reconstruction. Our findings may inform decisions among women considering various courses of surgical treatment. PMID:28058563

  14. Colors and Compositional Characteristics of Kuiper Belt Objects and Centaurs

    NASA Astrophysics Data System (ADS)

    Lederer, S. M.; Vilas, F.; Jarvis, K. S.; French, L.

    2001-11-01

    We present a study designed by Painter et al. (DPS 2000) to search for evidence of aqueous alteration in the surface material of solar system objects. Using VRI broadband photometry, we will search for the presence of the 0.7 um absorption feature (indicative of Fe-bearing hydrated silicates) in KBOs and Centaurs. Vilas (Icarus 111, 1994) found a strong correlation between the presence of the 0.7-um feature in low-albedo asteroids with solar-like colors and the 3-um water of hydration feature, indicative of phyllosilicates. Recent work by Howell et al. (LPSC, 2001) confirms that the presence of the 0.7 um feature in low-albedo asteroids definitely indicates the presence of the 3.0-um water of hydration absorption feature, suggesting the action of aqueous alteration in asteroids. In addition, Feierberg et al. (Icarus 63, 1985) showed that when the U - B color difference is > 0.12 in ECAS photometry, the 3.0-um absorption feature is often present in low albedo asteroids. Therefore, if the U-B color difference is > 0.12 and the 0.7-um feature is present in UBVRI reflectance photometry, water of hydration is implied in KBOs and Centaurs. We pursue these studies based on the mixed flat or steeply reddened photometry of these objects: Water ice has been identified in near-IR dark, flat spectra of some Centaurs, providing a source for the action of aqueous alteration. The complex collisional history proposed for these objects suggests a potential source of heating that would melt water ice, providing a mechanism for aqueous alteration to occur. Finally, we will use BVR photometry to determine the B-V and V-R colors, as has been done by Tegler and Romanishin (Nature, 407). We will compare our results with colors of KBOs and Centaurs published in the literature. This research was supported by the National Research Council and the NASA Planetary Astronomy Program.

  15. VizieR Online Data Catalog: Galactic CHaMP. II. Dense gas clumps. (Ma+, 2013)

    NASA Astrophysics Data System (ADS)

    Ma, B.; Tan, J. C.; Barnes, P. J.

    2015-04-01

    A total of 303 dense gas clumps have been detected using the HCO+(1-0) line in the CHaMP survey (Paper I, Barnes et al. 2011, J/ApJS/196/12). In this article we have derived the SED for these clumps using Spitzer, MSX, and IRAS data. The Midcourse Space Experiment (MSX) was launched in 1996 April. It conducted a Galactic plane survey (0

  16. High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina.

    PubMed

    Moya, G; Dorado, P; Ferreiro, V; Naranjo, M E G; Peñas-Lledó, E M; LLerena, A

    2017-07-01

    A twofold higher frequency of CYP2D6 ultrarapid metabolizers (estimated from genotype: gUMs) was reported among Ashkenazi Jews (AJ) living in New York (USA) than in other North American Caucasians, which might be important to guide the prescription for CYP2D6 substrates in AJ communities around the world. This study was aimed to determine whether the high frequency of CYP2D6 gUMs described in AJ from USA was replicated in AJ from Argentina when compared with other multiethnic admixture Argentines (GA). The frequency of the most common allelic variants and of CYP2D6 gUMs (>2 active genes) and poor metabolizers (0 active genes, gPMs) was also compared among the studied Argentine populations. CYP2D6 genotyping was performed in 173 AJ and 246 GA DNA samples of unrelated donors from the metropolitan area of Buenos Aires. CYP2D6 alleles (*2, *3, *4, *5, *6, *10, *17, *35, *41 and multiple copies), genotypes and functional phenotype frequencies were determined. The frequencies of gUMs and gPMs in AJ from Argentina were 11.5% and 5.2%, respectively, whereas in GA, the frequencies of gUM and gPMs were 6.5% and 4.9%, respectively. Comparisons between AJ and GA showed that gUMs frequencies were twofold higher (P<0.05) in AJ than GA. CYP2D6*35 allele was more frequent in GA than AJ, whereas CYP2D6*41 and *1xN were more frequent in AJ than in GA (P<0.05). This study supports the previously reported high frequency of gUMs on another Ashkenazi population in New York. The present findings also support the interethnic variability of CYP2D6 genetic polymorphism in the overall Argentine population.

  17. Transformation of Army National Guard Environmental Performance Assessment System (EPAS): Technologies and Best Practices in Field Audit Automation

    DTIC Science & Technology

    2012-05-01

    Lorenzo Richmond San Francisco San Mateo Sunnyvale Salinas Oakdale Reedley Hanford Visalia Fresno Modesto Stockton Indio Burbank Orange Fullerton Glendale...Riverside El Centro Camp Morena National City San Diego Barstow Ontario Bakersfield Apple Valley Los Angeles Santa Barbara Santa Maria Camp San Luis

  18. 76 FR 33270 - Cancellation of the Notice of Intent To Prepare a Programmatic Environmental Impact Statement for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... scale and stage of geothermal energy development at Superstition Mountain on Naval Air Facility El... geothermal energy program needs at Naval Air Facility El Centro. Should geothermal development be indicated... Programmatic Environmental Impact Statement for the Proposed Geothermal Development Program, Naval Air Facility...

  19. Classical biological control of cassava pests in Latin America and Africa

    USDA-ARS?s Scientific Manuscript database

    Anthony (Tony) Bellotti’s career took him to El Salvador with the Peace Corps in 1962, New Mexico State for a Masters, Paraguay (again with the Peace Corps), Cornell University for a Ph.D., and Colombia where he worked for the Centro Internacional de Agricultura Tropical (CIAT) from 1974 until his p...

  20. Questionnaire Evaluating Teaching Competencies in the University Environment. Evaluation of Teaching Competencies in the University

    ERIC Educational Resources Information Center

    Moreno-Murcia, Juan Antonio; Silveira Torregrosa, Yolanda; Belando Pedreño, Noelia

    2015-01-01

    The objective of this study was to design and validate a measuring instrument to evaluate the performance of university professors. The Evaluation of Teaching Performance (CEID [Centro de Estudios e Investigaciones Docentes (Center for Teaching Studies and Research)]) questionnaire was administered to 1297 university students. Various factor…

  1. The Integration of the Information and Communication Functions, and the Marketing of the Resulting Products.

    ERIC Educational Resources Information Center

    Harris, Susan C.

    1985-01-01

    Discusses the theoretical basis for integration of information functions and communication functions, the relevance of this integration in the scientific information cycle, and its positive effect on commodity research networks. The application of this theory is described using three commodity programs of the Centro Internacional de Agricultura…

  2. My Classroom: Peru

    ERIC Educational Resources Information Center

    Paglia, Deanna

    2015-01-01

    Angela Huanca Barrantes, a highly respected teacher of English as a foreign language (EFL) in the city of Ilo, has a strong impact on the lives of students at the Admirante Miguel Grau secondary school and at Centro Cultural Peruano Norteamericano, which is one of four binational centers in southern Peru. Due to Ms. Huanca's lack of understanding…

  3. Cancer immunotherapy without frontiers: 2nd Annual Immuno-Oncology Meeting of the Centro de Investigación de Cancer en Sonora (CICS), Ciudad Obregón, Sonora México, Dec 2-4, 2016.

    PubMed

    Gallardo-Rincón, Dolores; Marquez, Juan Pablo; Celis, Esteban

    2017-09-01

    This meeting in immuno-oncology brought together clinicians and scientists from United States, Canada, and México with the goal of breaking down international walls and establishing new collaborations.

  4. Closing the Gap: Merging Student Affairs, Advising and Registration

    ERIC Educational Resources Information Center

    Goomas, David T.

    2012-01-01

    In a pilot study at El Centro College, an urban college in the Dallas County Community College District, students in a new-to-college educational framework class were offered an intervention intended to enhance the academic advising process. The intervention consisted of in-class career services advising, degree selection, degree planning, course…

  5. Monozygotic Twin Pregnancy Associated with In Vitro Fertilization: Report and Revision of Three Cases Presented in a Clinic at 10,925 Feet Above Sea Level.

    PubMed

    Tominaga, Luis Vargas; Cáceres, Ricardo Pella; Lechuga, Alberto Vargas; Durán, Livia Bartolo; Vargas, Mariela Serrano

    2015-08-01

    3 cases of monozygotic twin pregnancies associated with IVF presented at Centro de Fertilidad y Ginecología del Sur. In this study, we describe the cases and review the literature, noting possible related factors.

  6. School Choice in Spain and the United States: A Comparative Study

    ERIC Educational Resources Information Center

    Umpstead, Regina; Jankens, Benjamin; Ortega Gil, Pablo; Weiss, Linda; Umpstead, Bruce

    2016-01-01

    This article explores issues of school choice in Spain and the United States by examining the roles and functions of "centros concertados," publicly funded private schools in Spain, and public charter schools in the United States, to provide key insights into the similarities and differences between them. After making a national…

  7. ELIMINATE TABOOS, OUTFIT YOUR LIBRARY IN SIX MONTHS.

    ERIC Educational Resources Information Center

    NEWMAN, MAYRELEE

    DURING A 6-MONTH PERIOD, EL CENTRO JUNIOR COLLEGE, DALLAS, TEXAS, ESTABLISHED A LEARNING RESOURCES LIBRARY FOR A 2,000-STUDENT POPULATION IN A FORMER DEPARTMENT STORE. THE TASK INCLUDED THREE GROUPS OF ACTIVITIES--(1) FACILITY PLANNING AND OBTAINING FURNITURE AND EQUIPMENT, (2) ACQUISITION AND PROCESSING OF A BASIC COLLECTION, INCLUDING PRINTED…

  8. An Indian Federation in Lowland Ecuador. IWGIA Document 28.

    ERIC Educational Resources Information Center

    Salazar, Ernesto

    Official involvement of the Ecuadorian government with colonization of the southern lowlands, lands traditionally belonging to the Shuar Indians, began in the early 60's when the CREA (Centro de Reconversion Economica del Azuay) was created to provide assistance to white settlers. Until that time, the Shuar lands had been dominated by the Salesian…

  9. Central radio galaxies in groups: cavities, bubbles and the history of AGN heating

    NASA Astrophysics Data System (ADS)

    Giacintucci, S.; Venturi, T.; Raychaudhury, S.; Vrtilek, J.

    2008-10-01

    E' noto che le regioni centrali degli ammassi e gruppi di galassie costituiscono un ambiente in cui gas caldo e plasma radioemittente proveniente dalle galassie dominanti interagiscono tra loro. In particolare, si pensa che la radioemissione dell'AGN centrale ed i suoi possibili cicli di attivita', siano strettamente legati alla presenza di cavita' e "bubbles" nel gas intergalattico. Si presentera' lo status di un progetto osservativo effettuato con il Giant Metrewave Radio Telescope (GMRT, India) su di un campione di 18 gruppi di galassie, osservati a tre frequenze radio (235 MHz, 325 MHz e 610 MHz). Lo studio della morfologia radio degli AGN centrali e la relativa analisi spettrale permettono di ottenere stime sull'eta' di questi oggetti, e sulla loro energia totale, che a loro volta sono in relazione con le proprieta' X dei gruppi stessi. Per tutti gli oggetti del campione sono disponibili osservazioni Chandra di proprieta'. Per due oggetti del campione, 4C+24.36 (al centro di AWM04) e NGC741 (al centro di RSOG17) verra' presentato uno studio dettagliato.

  10. Accidents on board merchant ships. Suggestions based on Centro Internazionale Radio Medico (CIRM) experience.

    PubMed

    Napoleone, Paolo

    2016-01-01

    This statistical study was performed to find out the occurrence of accidents on board ships assisted by Centro Internazionale Radio Medico (CIRM) during the years 2010-2015, with the aim of providing suggestions in accident prevention, based on such a wide experience. The case histories of CIRM in the years 2010-2015 were examined. The total number of accidents per year was calculated and compared as a percentage with the total number of cases assisted by CIRM per year. The incidence of accidents on board in these years ranged between 14.4% and 18.4% of total cases assisted per year, which is constantly increasing. The most common injuries on board among cases treated by CIRM were contusions and wounds. Also burns and eye injuries were significantly represented. Multiple injuries and head injuries were found to be the most frequent cause of death on board due to an accident. More information on the occurrence and type of accidents and on the body injured areas should represent the basis for developing strategies and campaigns for their prevention.

  11. VizieR Online Data Catalog: [CII] emission in the ISM of 20 nearby galaxies (Croxall+, 2017)

    NASA Astrophysics Data System (ADS)

    Croxall, K. V.; Smith, J. D.; Pellegrini, E.; Groves, B.; Bolatto, A.; Herrera-Camus, R.; Sandstrom, K. M.; Draine, B.; Wolfire, M. G.; Armus, L.; Boquien, M.; Brandl, B.; Dale, D.; Galametz, M.; Hunt, L.; Kennicutt, R.; Kreckel, K.; Rigopoulou, D.; van der Werf, P.; Wilson, C.

    2018-04-01

    Our observations include photometric and spectral-line observations from both the PACS and SPIRE instruments onboard Herschel, obtained as part of the large KINGFISH (Key Insights on Nearby Galaxies: a Far- Infrared Survey with Herschel, Kennicutt+ 2011PASP..123.1347K) and BtP (Beyond the Peak; OT1_jsmith1; P.I. J.D. Smith) projects. [NII]205um BtP observations were performed with SPIRE-FTS intermediate mapping, which is a 4-point dither. E. Pellegrini et al. (2017, in preparation) will contain a full description of the observations and reductions. [CII]158um and [NII]122um emission lines, and 70 and 160um continuum maps have been observed as part the Herschel Open Time Key Program KINGFISH. The data and the associated reduction are described in Kennicutt+ (2011PASP..123.1347K) and Croxall+ (2013ApJ...777...96C). (2 data files).

  12. Development of a compact E ? B microchannel plate detector for beam imaging

    DOE PAGES

    Wiggins, B. B.; Singh, Varinderjit; Vadas, J.; ...

    2017-06-17

    A beam imaging detector was developed by coupling a multi-strip anode with delay line readout to an E×B microchannel plate (MCP) detector. This detector is capable of measuring the incident position of the beam particles in one-dimension. To assess the spatial resolution, the detector was illuminated by an α-source with an intervening mask that consists of a series of precisely-machined slits. The measured spatial resolution was 520 um source FWHM, which was improved to 413 um FWHM by performing an FFT of the signals, rejecting spurious signals on the delay line, and requiring a minimum signal amplitude. This measured spatialmore » resolution of 413 um FWHM corresponds to an intrinsic resolution of 334 um FWHM when the effect of the finite slit width is de-convoluted. To understand the measured resolution, the performance of the detector is simulated with the ion-trajectory code SIMION.« less

  13. Development of a compact E ? B microchannel plate detector for beam imaging

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wiggins, B. B.; Singh, Varinderjit; Vadas, J.

    A beam imaging detector was developed by coupling a multi-strip anode with delay line readout to an E×B microchannel plate (MCP) detector. This detector is capable of measuring the incident position of the beam particles in one-dimension. To assess the spatial resolution, the detector was illuminated by an α-source with an intervening mask that consists of a series of precisely-machined slits. The measured spatial resolution was 520 um source FWHM, which was improved to 413 um FWHM by performing an FFT of the signals, rejecting spurious signals on the delay line, and requiring a minimum signal amplitude. This measured spatialmore » resolution of 413 um FWHM corresponds to an intrinsic resolution of 334 um FWHM when the effect of the finite slit width is de-convoluted. To understand the measured resolution, the performance of the detector is simulated with the ion-trajectory code SIMION.« less

  14. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma

    PubMed Central

    Chua, Vivian; Lapadula, Dominic; Randolph, Clinita; Benovic, Jeffrey L.; Wedegaertner, Philip; Aplin, Andrew E.

    2017-01-01

    Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease. The liver is the predominant organ of metastasis. There is an important need to provide effective treatment options for advanced stage UM. In order to provide the preclinical basis for new treatments, it is important to understand the molecular underpinnings of the disease. Recent genomic studies have shown that mutations within components of G protein-coupled receptor (GPCR) signaling are early events associated with ~98% of UMs. Implications This review discusses the alterations in GPCR signaling components (GNAQ and GNA11), dysregulated GPCR signaling cascades, and viable targeted therapies with the intent to provide insight into new therapeutic strategies in UM. PMID:28223438

  15. A Student Authored Online Medical Education Textbook: Editing Patterns and Content Evaluation of a Medical Student Wiki

    PubMed Central

    Thompson, CL; Schulz1, Wade L.; Terrence, Adam

    2011-01-01

    The University of Minnesota medical student wiki (UMMedWiki) allows students to collaboratively edit classroom notes to support medical education. Since 2007, UMMedWiki has grown to include 1,591 articles that have collectively received 1.2 million pageviews. Although small-scale wikis have become increasingly important, little is known about their dynamics compared to large wikis, such as Wikipedia. To better understand UMMedWiki’s management and its potential reproducibility at other medical schools, we used an edit log with 28,000 entries to evaluate the behavior of its student editors. The development of tools to survey UMMedwiki allows for quality comparisons that improve both the wiki and the curriculum itself. We completed a content survey by comparing the UMMedWiki with two types of rubric data: TIME, a medical education taxonomy consisting of 1500 terms and national epidemiological data on 2,100 diseases. PMID:22195202

  16. Whole-Genome Sequencing and Comparative Analysis of Mycobacterium brisbanense Reveals a Possible Soil Origin and Capability in Fertiliser Synthesis.

    PubMed

    Wee, Wei Yee; Tan, Tze King; Jakubovics, Nicholas S; Choo, Siew Woh

    2016-01-01

    Mycobacterium brisbanense is a member of Mycobacterium fortuitum third biovariant complex, which includes rapidly growing Mycobacterium spp. that normally inhabit soil, dust and water, and can sometimes cause respiratory tract infections in humans. We present the first whole-genome analysis of M. brisbanense UM_WWY which was isolated from a 70-year-old Malaysian patient. Molecular phylogenetic analyses confirmed the identification of this strain as M. brisbanense and showed that it has an unusually large genome compared with related mycobacteria. The large genome size of M. brisbanense UM_WWY (~7.7Mbp) is consistent with further findings that this strain has a highly variable genome structure that contains many putative horizontally transferred genomic islands and prophage. Comparative analysis showed that M. brisbanense UM_WWY is the only Mycobacterium species that possesses a complete set of genes encoding enzymes involved in the urea cycle, suggesting that this soil bacterium is able to synthesize urea for use as plant fertilizers. It is likely that M. brisbanense UM_WWY is adapted to live in soil as its primary habitat since the genome contains many genes associated with nitrogen metabolism. Nevertheless, a large number of predicted virulence genes were identified in M. brisbanense UM_WWY that are mostly shared with well-studied mycobacterial pathogens such as Mycobacterium tuberculosis and Mycobacterium abscessus. These findings are consistent with the role of M. brisbanense as an opportunistic pathogen of humans. The whole-genome study of UM_WWY has provided the basis for future work of M. brisbanense.

  17. Patterns of morphological variation in enamel–dentin junction and outer enamel surface of human molars

    PubMed Central

    Morita, Wataru; Yano, Wataru; Nagaoka, Tomohito; Abe, Mikiko; Ohshima, Hayato; Nakatsukasa, Masato

    2014-01-01

    Tooth crown patterning is governed by the growth and folding of the inner enamel epithelium (IEE) and the following enamel deposition forms outer enamel surface (OES). We hypothesized that overall dental crown shape and covariation structure are determined by processes that configurate shape at the enamel–dentine junction (EDJ), the developmental vestige of IEE. This this hypothesis was tested by comparing patterns of morphological variation between EDJ and OES in human permanent maxillary first molar (UM1) and deciduous second molar (um2). Using geometric morphometric methods, we described morphological variation and covariation between EDJ and OES, and evaluated the strength of two components of phenotypic variability, canalization and morphological integration, in addition to the relevant evolutionary flexibility, i.e. the ability to respond to selective pressure. The strength of covariation between EDJ and OES was greater in um2 than in UM1, and the way that multiple traits covary between EDJ and OES was different between these teeth. The variability analyses showed that EDJ had less shape variation and a higher level of morphological integration than OES, which indicated that canalization and morphological integration acted as developmental constraints. These tendencies were greater in UM1 than in um2. On the other hand, EDJ and OES had a comparable level of evolvability in these teeth. Amelogenesis could play a significant role in tooth shape and covariation structure, and its influence was not constant among teeth, which may be responsible for the differences in the rate and/or period of enamel formation. PMID:24689536

  18. Delivering informatics capabilities to an AHC research community through public/private partnerships (PPP).

    PubMed

    Smith, Kevin A; Athey, Brian D; Chahal, Amar P S; Sahai, Priti

    2008-11-06

    Velos eResearch is a commercially-developed, regulatory-compliant, web-based clinical research information system from Velos Inc. Aithent Inc. is a software development services company. The University of Michigan (UM) has public/private partnerships with Velos and Aithent to collaborate on development of additional capabilities, modules, and new products to better support the needs of clinical and translational research communities. These partnerships provide UM with a mechanism for obtaining high-quality functionally comprehensive capabilities more quickly and at lower cost, while the corporate partners get a quality advisory and development partner--this benefits all parties. The UM chose to partner with Velos in part because of its commitment to interoperability. Velos is an active participant in the NCI caBIG project and is committed to caBIG compatibility. Velos already provides interoperability with other Velos sites in the CTSA context. One example of the partnership is co-development of integrated specimen management capabilities. UM spent more than a year defining business requirements and technical specifications for, and is funding development of, this capability. UM also facilitates an autonomous user community (20+ institutions, 7 CTSA awardees); the broad goal of the group is to share experiences, expertise, identify collaborative opportunities, and support one another as well as provide a source of future needs identification to Velos. Advantages and risks related to delivering informatics capabilities to an AHC research community through a public/private partnership will be presented. The UM, Velos and Aithent will discuss frameworks, agreements and other factors that have contributed to a successful partnership.

  19. Clinical analysis of a large kindred with the pallister ulnar-mammary syndrome

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bamshad, M.; Root, S.; Carey, J.C.

    1996-11-11

    The ulnar-mammary syndrome (UMS) is an autosomal dominant disorder characterized by posterior limb deficiencies or duplications, apocrine/mammary gland hypoplasia and/or dysfunction, abnormal dentition, delayed puberty in males, and genital anomalies. We present the clinical descriptions of 33 members of a six generation kindred with UMS. The number of affected individuals in this family is more than the sum of all previously reported cases of UMS. The clinical expression of UMS is highly variable. While most patients have limb deficiencies, the range of abnormalities extends from hypoplasia of the terminal phalanx of the 5th digit to complete absence of the ulnamore » and 3rd, 4th, and 5th digits. Moreover, affected individuals may have posterior digital duplications with or without contralateral limb deficiencies. Apocrine gland abnormalities range from diminished axillary perspiration with normal breast development and lactation, to complete absence of the breasts and no axillary perspiration. Dental abnormalities include misplaced or absent teeth. Affected males consistently undergo delayed puberty, and both sexes have diminished to absent axillary hair. Imperforate hymen were seen in some affected women. A gene for UMS was mapped to chromosome area 12q23-q24.1. A mutation in the gene causing UMS can interfere with limb patterning in the proximal/distal, anterior/posterior, and dorsal/ventral axes. This mutation disturbs development of the posterior elements of forearm, wrist, and hand while growth and development of the anterior elements remain normal. 24 refs., 4 figs., 1 tab.« less

  20. [Not Available].

    PubMed

    Vergara, Diego; Ríos-Reina, Rocío; Úbeda, Cristina; Escudero-Gilete, M Luisa; Callejón, Raquel M

    2016-06-30

    Introducción: en la actualidad existe un déficit en la evaluación de comedores dirigidos a niños menores de 3 años, a pesar de que se han realizado numerosas intervenciones en los comedores escolares con el fin de conseguir una alimentación segura y adecuada.Objetivo: realizar una evaluación nutricional de los menús ofertados en los centros de educación infantil de Sevilla.Material y métodos: se evaluó la frecuencia, variedad, rotación de alimentos, métodos culinarios e información de los menús de seis centros infantiles de Sevilla. Se valoró el aporte energético y nutricional mediante el programa Dietowin® y el método de pesada.Resultados: las frutas y verduras fueron deficitarias en la mayoría de los menús, y excesivas la carne, patatas, pasta y arroz. Se observó una escasa variedad de recetas por grupo de alimentos y no se daba una información completa del menú. Sin embargo, la variedad de procesos culinarios y la rotación de alimentos fueron adecuadas. Aunque la energía y el aporte de carbohidratos (~55%) se ajustaban a las necesidades, se observó un aporte excesivo de proteínas (~19%) y deficiente de lípidos (< 30%), sobre todo de grasas insaturadas. Respecto a los micronutrientes,solo vitamina C, E y calcio estaban por debajo de lo recomendado.Conclusiones: los centros de educación infantil están haciendo un gran esfuerzo por cumplir las recomendaciones nutricionales, pero todavía deben disminuir el aporte proteico y aumentar las grasas insaturadas de la dieta. Además, deben fomentar la oferta de frutas y verduras, ampliar la variedad de recetas, dar mayor información y disminuir el aporte de alimentos cárnicos.

  1. PubMed

    Valero Gaspar, Teresa; Del Pozo de la Calle, Susana; Ruiz Moreno, Emma; Ávila Torres, Osé Manuel; Varela-Moreiras, Gregorio; Cuadrado Vives, Carmen

    2016-11-29

    Introducción: a finales del siglo xx, no se conocía con precisión si la comida del comedor escolar contribuía adecuadamente a la dieta de la población infantil. Además, este servicio complementario no se contemplaba en el proyecto educativo del centro pese a considerarse fundamental en todas sus dimensiones.Objetivo: describir el origen y desarrollo del programa de comedores escolares de la Comunidad de Madrid (CM) en 15 años desde su implantación.Métodos: se elaboró una normativa a cumplir por las empresas de restauración, y que contemplaba aspectos nutricionales y de composición y variedad de los menús, que se utilizó en los concursos para acceder a la prestación del servicio de comedor escolar, publicados en los años 2001, 2002, 2005, 2009 y 2013. Además se realizaron visitas acreditadas a los centros sin previo aviso para verifi car el cumplimiento de la documentación aportada durante el concurso.Resultados: los criterios más actuales sobre programación y elaboración de menús escolares se recogen en el Pliego de Prescripciones Técnicas del año 2013 (C-504/001-2013). Un 92% de las empresas de restauración superaron los cinco concursos habidos en los 15 años de funcionamiento. Hasta el año 2014, se han realizado 755 visitas, revisándose un total de 574 centros.Conclusiones: el programa de comedores escolares de la CM, desde su implementación pionera en España, ha contribuido a la mejora del servicio complementario de comedor. En estos años se han ido incluyendo nuevos requisitos dietéticos y nutricionales que han logrado menús cada vez más ajustados a las recomendaciones de la población escolar.

  2. The International Space Station Urine Monitoring System (UMS)

    NASA Technical Reports Server (NTRS)

    Feeback, Daniel L.; Cibuzar, Branelle R.; Milstead, Jeffery R.; Pietrzyk,, Robert A.; Clark, Mark S.F.

    2009-01-01

    A device capable of making in-flight volume measurements of single void urine samples, the Urine Monitoring System (UMS), was developed and flown on seven U.S. Space Shuttle missions. This device provided volume data for each urine void from multiple crewmembers and allowed samples of each to be taken and returned to Earth for post-flight analysis. There were a number of design flaws in the original instrument including the presence of liquid carry-over producing invalid "actual" micturition volumes and cross-contamination between successive users from residual urine in "dead" spots". Additionally, high or low volume voids could not be accurately measured, the on-orbit calibration and nominal use sequence was time intensive, and the unit had to be returned and disassembled to retrieve the volume data. These problems have been resolved in a new version, the International Space Station (ISS) UMS, that has been designed to provide real-time in-flight volume data with accuracy and precision equivalent to measurements made on Earth and the ability to provide urine samples that are unadulterated by the device. Originally conceived to be interfaced with a U.S.-built Waste Collection System (WCS), the unit now has been modified to interface with the Russian-supplied Sanitary Hygiene Device (ASY). The ISS UMS provides significant advantages over the current method of collecting urine samples into Urine Collection Devices (UCDs), from which samples are removed and returned to Earth for analyses. A significant future advantage of the UMS is that it can provide an interface to analytical instrumentation that will allow real-time measurement of urine bioanalytes allowing monitoring of crewmember health status during flight and the ability to provide medical interventions based on the results of these measurements. Currently, the ISS UMS is scheduled to launch along with Node-3 on STS-130 (20A) in December 2009. UMS will be installed and scientific/functional verification completed prior to placing the instrument into operation. Samples collected during the verification sequence will be returned for analyses on STS-131 (19A) currently scheduled for launch in March 2010. The presence of a UMS on ISS will provide the capability to conduct additional collaborative human life science investigations among the ISS International Partners.

  3. Performance of juvenile steelhead trout (Oncorhynchus mykiss) produced from untreated and cryopreserved milt

    USGS Publications Warehouse

    Hayes, Michael C.; Rubin, Stephen P.; Hensleigh, Jay E.; Reisenbichler, Reginald R.; Wetzel, Lisa A.

    2005-01-01

    Despite the expanding use of milt cryopreservation in aquaculture, the performance of fish produced from this technique has not been fully explored beyond initial rearing stages. We compared the performance of juvenile steelhead Oncorhynchus mykiss produced from untreated (UM) and cryopreserved milt (CM) and reared for 4–9 months. For the 1996 brood, CM alevins were heavier (∼ 1.7%, P < 0.01) than UM alevins and length was influenced by a significant milt-by-family interaction (P < 0.03) suggesting a greater treatment effect for some families. No significant differences were found in length or weight (P > 0.05) for 1997 brood alevins and percent yolk was similar for both broods (P > 0.34). In growth and survival experiment I (GSE-I, 1996), UM and CM juveniles reared in separate tanks and fed to satiation (130 days) showed no significant differences in survival, length or weight (P > 0.05) between milt groups. In contrast, for UM and CM siblings reared in the same tank for 210 days on a low food ration (GSE-II), survival was similar (P > 0.05), but length (UM 4% > CM, P < 0.05) and possibly weight (UM 15% > CM, P = 0.08), were influenced by cryopreservation. Fish from the 1997 brood (GSE-III) were reared for 313 days in a repeat of GSE-II and no differences were found in survival (P = 0.47), length (P = 0.75) or weight (P = 0.76) suggesting considerable heterogeneity between broods. Performance of the 1996 brood was also tested for response to stress and a disease challenge. Cortisol responses of juveniles exposed to acute stress were not significantly different (P = 0.19), but mean cortisol was consistently and significantly greater (P < 0.01) for CM than UM fish exposed to a 48-h stress (increased density). After exposure to three dosages of the bacteria, Listonella anguillarum, we found similar mortality proportions (P = 0.72) for UM and CM fish. Variable juvenile performance for the parameters tested indicated significant differences among broods and families and suggests a cautionary approach to the widespread use of cryopreservation for steelhead.

  4. Raízes pós-mitológicas da Astronomia Clássica

    NASA Astrophysics Data System (ADS)

    di Bartolo, L.; Villas da Rocha, J. F.

    2004-02-01

    Apresentamos como a invenção de um modelo astronômico e cosmológico fundado em causas naturais foi um processo gestado num ambiente cultural específico, o do advento do pensamento pós-mitológico, que tem como sua raiz mais funda a trajetória particular da Grécia Antiga, com ênfase na resolução de uma grave crise social e a evolução do mundo clássico para o contexto espiritual de um império universal.

  5. Dehydration and clearing of adult Drosophila for ultramicroscopy.

    PubMed

    Becker, Klaus; Jährling, Nina; Saghafi, Saiedeh; Dodt, Hans-Ulrich

    2013-07-01

    This protocol describes the preparation of adult flies for ultramicroscopy (UM), a powerful imaging technique that achieves precise and accurate three-dimensional (3D) reconstructions of intact macroscopic specimens with micrometer resolution. In UM, a specimen in the size range of ∼1-15 mm is illuminated perpendicular to the observation pathway by two thin counterpropagating sheets of laser light. Thus, specimens for UM need to be sufficiently transparent, which requires chemical clearing in most cases. In this protocol, Drosophila melanogaster adults are fixed, dehydrated in ethanol, and then cleared in a solution of benzyl alcohol and benzyl benzoate.

  6. VizieR Online Data Catalog: GJ 1214b optical and near-IR transit phot. (Angerhausen+, 2017)

    NASA Astrophysics Data System (ADS)

    Angerhausen, D.; Dreyer, C.; Placek, B.; Csizmadia, Sz.; Eigmueller, P.; Godolt, M.; Kitzmann, D.; Mallonn, M.; Becklin, E.; Collins, P.; Dunham, E. W.; Grenfell, J. L.; Hamilton, R. T.; Kabath, P.; Logsdon, S. E.; Mandell, A.; Mandushev, G.; McElwain, M.; McLean, I. S.; Pfueller, E.; Rauer, H.; Savage, M.; Shenoy, S.; Vacca, W. D.; van Cleve, J. E.; Wiedemann, M.; Wolf, J.

    2017-11-01

    The joint US-German Cycle 2 Guest Investigator (GI) programme - US-proposal: Angerhausen (2013); Germanproposal: Dreyer (2013) - was performed on SOFIAs flight number 149 on UT February 27, 2014. Observations were simultaneously conducted in two optical HIPO channels: open blue at 0.3-0.6um and Sloan z' at 0.9-m; and one infrared FLITECAM fiter: Paschen-α cont. at 1.9um. Complementary data were also obtained with the optical focal plane guiding camera FPI+ in the Sloan i' band (0.8um). (5 data files).

  7. Landsat 7 - First Cloud-free Image of Yellowstone National Park

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This image of Yellowstone Lake, in the center of Yellowstone National Park, was taken by Landsat 7 on July 13, 1999. Bands 5 (1.65um),4 (.825um), and 2 (.565um) were used for red, green, and blue, respectively. Water appears blue/black, snow light blue, mature forest red/green, young forest pink, and grass and fields appear light green. Southwest of the lake is young forest that is growing in the wake of the widespread fires of 1988. For more information, see: Landsat 7 Fact Sheet Landsat 7 in Mission Control Image by Rich Irish, NASA GSFC

  8. VizieR Online Data Catalog: ISOCAM survey of Serpens/G3-G6 (Djupvik+, 2006)

    NASA Astrophysics Data System (ADS)

    Djupvik, A. A.; Andre, P.; Bontemps, S.; Motte, F.; Olofsson, G.; Gaalfalk, M.; Floren, H.-G.

    2006-08-01

    We present results from an ISOCAM survey in the two broadband filters LW2 (5-8.5um) and LW3 (12-18um) of a 19'x16' field called Serp_NH3 centred on the optical group Serpens/G3-G6. A total of 186 sources were detected in the 6.7um band and/or the 14.3um band to a limiting sensitivity of ~2mJy. These have been cross-correlated with the 2MASS catalogue and are all listed in table1. Deep follow-up photometry in the Ks band obtained with Arnica at the Nordic Optical Telescope (NOT) is listed in table2. Deep L' band photometry of selected sources using SIRCA at the NOT is listed in table3. Continuum emission at 1.3mm and 3.6cm was observed with IRAM and VLA, respectively, and deep imaging in the 2.12um S(1) line of H2 was obtained with NOTCam at the NOT. We find strong evidence for a stellar population of 31 Class II sources (listed in table5), 5 flat-spectrum sources, 5 Class I sources (listed in table4), and two Class 0 sources. Our method does not sample the Class III sources. (3 data files).

  9. Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain.

    PubMed

    Alves, Sandro; Bode, Julia; Bemelmans, Alexis-Pierre; von Kalle, Christof; Cartier, Nathalie; Tews, Björn

    2016-06-20

    Recombinant adeno-associated viral (AAV) vectors have advanced to the vanguard of gene therapy. Numerous naturally occurring serotypes have been used to target cells in various tissues. There is a strong need for fast and dynamic methods which efficiently unravel viral tropism in whole organs. Ultramicroscopy (UM) is a novel fluorescence microscopy technique that images optically cleared undissected specimens, achieving good resolutions at high penetration depths while being non-destructive. UM was applied to obtain high-resolution 3D analysis of AAV transduction in adult mouse brains, especially in the hippocampus, a region of interest for Alzheimer's disease therapy. We separately or simultaneously compared transduction efficacies for commonly used serotypes (AAV9 and AAVrh10) using fluorescent reporter expression. We provide a detailed comparative and quantitative analysis of the transduction profiles. UM allowed a rapid analysis of marker fluorescence expression in neurons with intact projections deep inside the brain, in defined anatomical structures. Major hippocampal neuronal transduction was observed with both vectors, with slightly better efficacy for AAV9 in UM. Glial response and synaptic marker expression did not change post transduction.We propose UM as a novel valuable complementary tool to efficiently and simultaneously unravel tropism of different viruses in a single non-dissected adult rodent brain.

  10. Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics.

    PubMed

    Bailey, Fiona P; Clarke, Kim; Kalirai, Helen; Kenyani, Jenna; Shahidipour, Haleh; Falciani, Francesco; Coulson, Judy M; Sacco, Joseph J; Coupland, Sarah E; Eyers, Patrick A

    2018-03-01

    Metastatic uveal melanoma (UM) is invariably fatal, usually within a year of diagnosis. There are currently no effective therapies, and clinical studies employing kinase inhibitors have so far demonstrated limited success. This is despite common activating mutations in GNAQ/11 genes, which trigger signalling pathways that might predispose tumours to a variety of targeted drugs. In this study, we have profiled kinome expression network dynamics in various human ocular melanomas. We uncovered a shared transcriptional profile in human primary UM samples and across a variety of experimental cell-based models. The poor overall response of UM cells to FDA-approved kinase inhibitors contrasted with much higher sensitivity to the bromodomain inhibitor JQ1, a broad transcriptional repressor. Mechanistically, we identified a repressed FOXM1-dependent kinase subnetwork in JQ1-exposed cells that contained multiple cell cycle-regulated protein kinases. Consistently, we demonstrated vulnerability of UM cells to inhibitors of mitotic protein kinases within this network, including the investigational PLK1 inhibitor BI6727. We conclude that analysis of kinome-wide signalling network dynamics has the potential to reveal actionable drug targets and inhibitors of potential therapeutic benefit for UM patients. © 2017 The Authors. Pigment Cell & Melanoma Research Published by John Wiley & Sons.

  11. VizieR Online Data Catalog: Water masers in M31. I. Recombination lines (Darling+, 2016)

    NASA Astrophysics Data System (ADS)

    Darling, J.; Gerard, B.; Amiri, N.; Lawrence, K.

    2016-09-01

    We constructed a catalog of 506 unresolved 24um sources from the Spitzer 24um map of M31 (Gordon et al. 2006ApJ...638L..87G); see Figure 1. Darling (2011ApJ...732L...2D) observed 206 24um sources in M31 using the Green Bank Telescope (GBT) in 2010 October through December. The 616-523 22.23508GHz ortho-water maser line observations were reported in Darling (2011ApJ...732L...2D), but simultaneous observations of the para-ammonia (NH3) rotational ground-state inversion transitions in the metastable states (J,K)=(1,1) and (2,2) at 23.6945 and 23.72263GHz, respectively, and the hydrogen recombination line H66α at 22.36417GHz were not. We subsequently observed all four of these lines toward an additional 300 24um sources in 2011 October through 2012 January. The resolution of the 24um Spitzer image is 6" (Gordon et al. 2006ApJ...638L..87G), so the unresolved IR sources remained within the 33" GBT beam even during the largest pointing drifts. The 33" beam (FWHM) at 22GHz spans 125pc in M31. (1 data file).

  12. The Athenæum Club, the Royal Society and the reform of dentistry in nineteenth-century Britain: A research report

    PubMed Central

    Bishop, Malcolm G. H.

    2017-01-01

    In 1978 M. J. Peterson examined the role played by the Royal College of Surgeons (RCS) in nineteenth-century dental reform, noting the establishment of its Licence in Dental Surgery (LDS) in 1859. In a paper published in Notes and Records in 2010, the present author described the influential role played by Fellows of the Royal Society during the nineteenth-century campaign for dental reform led by Sir John Tomes. Key players in this campaign, including the dentists Samuel Cartwright, Thomas Bell and James Salter, were, as well as being Fellows of the Royal Society, members of the Athenæum Club. The present research report indicates the roles played by those members of the Athenæum Club who were also Fellows of the Royal Society in the scientific and professional reform of nineteenth-century dentistry. Although it does not attempt to document meetings at the Club, it suggests the potential for a symbiotic effect between the Royal Society and the Athenæum. Where the previous paper proposed an active scientific role for the Royal Society in reforming dentistry, this paper presents the Athenæum as a significant extension of the sphere of influence into the cultural realm for those who did enjoy membership of both organizations.

  13. Polycyclic aromatic hydrocarbons produced by electrocautery smoke and the use of personal protective equipment 1.

    PubMed

    Claudio, Caroline Vieira; Ribeiro, Renata Perfeito; Martins, Júlia Trevisan; Marziale, Maria Helena Palucci; Solci, Maria Cristina; Dalmas, José Carlos

    2017-03-02

    analyze the concentration of polycyclic aromatic hydrocarbons in electrocautery smoke in operating rooms and the use of personal protective equipment by the intraoperative team when exposed to hydrocarbons. exploratory and cross-sectional field research conducted in a surgery center. Gases were collected by a vacuum suction pump from a sample of 50 abdominal surgeries in which an electrocautery was used. A form was applied to identify the use of personal protective equipment. Gases were analyzed using chromatography. Descriptive statistics and Spearman's test were used to treat data. there were 17 (34%) cholecystectomies with an average duration of 136 minutes, while the average time of electrocautery usage was 3.6 minutes. Airborne hydrocarbons were detected in operating rooms in 100% of the surgeries. Naphthalene was detected in 48 (96.0%) surgeries and phenanthrene in 49 (98.0%). The average concentration of these compounds was 0.0061 mg/m3 and a strong correlation (0.761) was found between them. The intraoperative teams did not use respirator masks such as the N95. electrocautery smoke produces gases that are harmful to the health of the intraoperative team, which is a concern considering the low adherence to the use of personal protective equipment. analizar las concentraciones de hidrocarburos policíclicos aromáticos provenientes del humo del electrocauterio en salas quirúrgicas y el uso de equipamientos de protección individual por parte del equipo intraoperatorio, cuando expuestos a los hidrocarburos. investigación de campo, exploratoria y transversal realizada en un centro quirúrgico. En la muestra, compuesta por 50 cirugías abdominales con uso de electrocauterio, los gases fueron recolectados con una bomba de succión de vacío. Se aplicó un formulario para identificar el uso de los equipamientos de protección. Se realizó la lectura de los gases por medio de cromatografía. Los datos fueron analizados con la estadística descriptiva y el test de Spearman. 17 (34%) fueron colecistectomías con tiempo medio quirúrgico de 136 minutos y tiempo medio de uso del electrocauterio de 3,6 minutos. Fueron detectados hidrocarburos en el aire de las salas de operación en 100% de las cirugías. Se detectó el naftaleno en 48 (96,0%) cirugías y el fenantreno en 49 (98,0%). Las concentraciones promedio de esos compuestos fueron de 0,0061 mg/m3. Hubo correlación (0,761) fuerte entre estos compuestos. El equipo intraoperatorio no utilizó máscaras respiratorias, como la N95. el humo del electrocauterio produce gases perjudiciales para la salud del equipo intraoperatorio que se encuentra expuesto debido a la baja adhesión al uso de equipamientos de protección individual, tornando preocupante esta exposición. analisar as concentrações de hidrocarbonetos policíclicos aromáticos provenientes da fumaça do eletrocautério em salas cirúrgicas e o uso de equipamentos de proteção individual pela equipe intraoperatória quando expostos aos hidrocarbonetos. pesquisa de campo, exploratória e transversal realizada em um centro cirúrgico. Na amostra composta por 50 cirurgias abdominais com uso de eletrocautério, os gases foram coletados por bomba de sucção a vácuo. Um formulário foi aplicado para identificar o uso dos equipamentos de proteção. Realizou-se a leitura dos gases por cromatografia. Os dados foram analisados por estatística descritiva e teste de Spearman. 17 (34%) foram as colecistectomias com tempo médio cirúrgico de 136 minutos e tempo médio de uso do eletrocautério de 3,6 minutos. Hidrocarbonetos foram detectados no ar das salas operatórias em 100% dos atos cirúrgicos. Detectou-se o naftaleno em 48 (96,0%) cirurgias e o fenantreno em 49 (98,0%). As concentrações médias desses compostos foram de 0,0061 mg/m3. Houve correlação (0,761) forte entre estes compostos. A equipe intraoperatória não utilizou máscaras respiratórias, como a N95. a fumaça do eletrocautério produz gases prejudiciais à saúde da equipe intraoperatória exposta e diante da baixa adesão ao uso de equipamentos de proteção individual, tornando-se preocupante esta exposição.

  14. The Development of Spanish Airpower Doctrine (1910-1936)

    DTIC Science & Technology

    2002-04-01

    in Spain, including civil and commercial airlines, social air mindedness, national industry, and military aviation. “Reorganización y nuevos ... Proyecto de Reorganización de la Sección y Dirección de Aeronáutica en un Centro único con el nombre de Dirección. Signed by Gen Francisco Echague, as

  15. La Communicacion entre los Centros de Investigacion en Educacion (Communication among Educational Research Centers).

    ERIC Educational Resources Information Center

    Schiefelbein, Ernesto

    1972-01-01

    In Latin America there is a lack of communication concerning educational research. This lack has been underlined in many regional meetings, but no action has been taken. Possible steps that would lead to improvement include circulation of research summaries, both for completed and current works, efforts by research centers to organize meetings,…

  16. Servicos Do Centro De Solucoes De Energia Limpa (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2014-06-01

    This is the Portuguese translation of the Clean Energy Solutions Center Services fact sheet. The Solutions Center helps governments, advisors and analysts create policies and programs that advance the deployment of clean energy technologies. The Solutions Center partners with international organizations to provide online training, expert assistance, and technical resources on clean energy policy.

  17. Promoting Entrepreneurial Culture in the University: The Institutional Collaborative Model at the Universidad Autonoma de Madrid

    ERIC Educational Resources Information Center

    de Pablo, Isidro; Alfaro, Fernando; Rodriguez, Miriam; Valdes, Esperanza

    2011-01-01

    This paper presents a case of collaboration between different types of public services and the private sector for the promotion of an entrepreneurial culture. This collaboration is achieved by means of a centre established and developed by the Universidad Autonoma de Madrid, the Centro de Iniciativas Emprendedoras (the Centre for Entrepreneurial…

  18. PIA Program | CTIO

    Science.gov Websites

    se cuenta con los fondos necesarios para efectuar el Programa PIA para el 2018. We do, on occasion Observatorio Inter-Americano de Cerro Tololo es el centro nacional de los Estados Unidos para el desarrollo de unos 400 kms al norte de Santiago. Los telescopios se ubican en la cima de Cerro Tololo, a 90 kms al

  19. A tribute to Dr. Anthony C. Bellotti and his contributions to cassava entomology

    USDA-ARS?s Scientific Manuscript database

    Anthony (Tony) Bellotti’s career as a humanitarian and entomologist followed a trajectory that took him to El Salvador with the Peace Corps (PC) in 1962, New Mexico State for a Masters, Paraguay (again with the Peace Corps), Cornell University for a PhD, and Colombia where he worked for the Centro I...

  20. The Structure and Functioning of a Low-Budget Center for Applied Linguistics: The Brazilian Experience.

    ERIC Educational Resources Information Center

    Gomes de Matos, Francisco

    1980-01-01

    Describes the structure and functioning of the "Centro de Linguistica Aplicada do Instituto de Idiomas Yazigi" of Sao Paulo and comments on its role in promoting applied linguistics studies in Latin America. Also outlines the Center's historical background and its educational services, particularly those related to the teaching of…

  1. World Perspective Case Descriptions on Educational Programs for Adults: Chile.

    ERIC Educational Resources Information Center

    Donoso, Patricio; Gajardo, Marcela

    This document contains two case studies of adult education programs in Chile. Both case studies begin with a "face sheet" on which is recorded basic information about the program and the description. The first case study, prepared by Patricio Donoso, reports on Centro El Canelo de Nos, an inservice center for educators who work with…

  2. Revista Interamericana de Educacion de Adultos, 1999 (Interamerican Review of Adult Education, 1999).

    ERIC Educational Resources Information Center

    Soberanes, Juan F. Millan, Ed.

    1999-01-01

    This journal, written in Spanish, is a publication of the Centro de Cooperacion Regional para la Educacion de Adultos en America Latina y el Caribe (CREFAL), published in conjunction with the OAS. Its main objective is the dissemination of information on research and theoretical and methodological innovation in the field of adult education.…

  3. Sexual Abuse Experiences of Women in Peru: An Exploratory Study

    ERIC Educational Resources Information Center

    Deboer, Rebekah E.; Tse, Luke M.

    2010-01-01

    This ethnographic study relied primarily on case notes and interviews with the president of Centro Prenatal Vida Nueva, a pregnancy center in Lima, Peru, to study the sexual abuse experiences of 33 Peruvian women. Given the language limitations of the researchers, the analyses were completed in collaboration with the president of the center, a…

  4. Atomic Data for Fusion. Volume 5: Collisions of Carbon and Oxygen Ions with Electrons, H, H2 and He

    DTIC Science & Technology

    1987-02-01

    Atomico Bariloche , 8400 San Carlos De Bariloche, Argentina 438. Dr. S. V. Mirnov, I. V. Kurchatov Institute Of, Atomic Energy, Ulitsa Kurchatova, 46...Bldg. R25, Space and Astrophysics Div., Rutherford Appleton Lab., Chilton, Didcot, Oxfordshire OX1I OQX, United Kingdom 437. Dr. W. Meckbach, Centro

  5. p-Forms and diffeomorphisms: Hamiltonian formulation

    NASA Astrophysics Data System (ADS)

    Baulieu, Laurent; Henneaux, Marc

    1987-07-01

    The BRST charges corresponding to various (equivalent) ways of writing the action of the diffeomorphism group on p-form gauge fields are canonically related by a canonical transformation in the extended phase space which is explicitly constructed. The occurrence of higher order structure functions is pointed out. Also at: Centro de Estudios Cientificos de Santiago, Casilla 16443, Santiago 9, Chile.

  6. Organizing MySpace: Youth Walkouts, Pleasure, Politics, and New Media

    ERIC Educational Resources Information Center

    Yang, K. Wayne

    2007-01-01

    While the major urban centers around the country were flooded by millions of protesters demanding immigrant rights in March 2006, the San Francisco Bay Area remained relatively quiet. A coalition of organizers, including Centro Legal de la Raza, Deporten A La Migra, and the Bay Area Immigrant Rights Coalition mobilized a one-week hunger strike,…

  7. The Indian Liberation and Social Rights Movement in Kollasuyu (Bolivia). IWGIA Document 30.

    ERIC Educational Resources Information Center

    Apaza, Julio Tumiri, Ed.

    For some time the Aymara and Quechua Indians have been adopting resolutions and submitting them to the relevant authorities. Compiled by the Centro de Coordinacion y Promocion Campesina "Mink'A" for consideration by the "First Meeting of Anthropologists in the Andean Region" held in September 1975, this document gives a general…

  8. CILA: A New Approach to Problems in the Acquisition of Latin American Library Materials.

    ERIC Educational Resources Information Center

    Clouston, John Samuel

    This paper attempts to provide a contextual study of CILA--Centro Interamericano de Libros Academicos--a new scheme for the distribution of scholarly books in the Americas. Because of the scheme's peculiar relevance to the needs of Canadian academic libraries, the status of Latin American studies and relevant library collections in Canada are…

  9. Learning to Live Together: A Challenge for Schools Located in Contexts of Social Vulnerability

    ERIC Educational Resources Information Center

    Grau, Roser; García-Raga, Laura

    2017-01-01

    Currently, there are many educational centres that demonstrate the need to promote initiatives to improve coexistence at school at the international level, especially in those located in contexts of social vulnerability. A socio-educational programme has been developed, applied and evaluated at a Singular Education Action Centre (Centro de Acción…

  10. In-Course Instructor-Guided Service Learning in a Community College General Psychology Class

    ERIC Educational Resources Information Center

    Goomas, David T.; Weston, Melissa B.

    2012-01-01

    Students enrolled in two general psychology classes at El Centro College (ECC) of the Dallas County Community College District (DCCCD) were offered the opportunity to earn extra credit by performing up to 20 hours of service learning. Benefits of service learning were observed in student development, including exploration of career possibilities,…

  11. 543 N McClurg, October 2010, Lindsay Light Radiological Survey

    EPA Pesticide Factsheets

    The field gamma measurements within the excavation andthe spoil materials generated during the excavation process did not exceed the respective thresholdvalues previously stated and ranged from a minim um of 1,020 cpm to a maxim um of 7,150 cpm.

  12. VizieR Online Data Catalog: FourStar galaxy evolution survey (ZFOURGE) (Straatman+, 2016)

    NASA Astrophysics Data System (ADS)

    Straatman, C. M. S.; Spitler, L. R.; Quadri, R. F.; Labbe, I.; Glazebrook, K.; Persson, S. E.; Papovich, C.; Tran, K.-V.; Brammer, G. B.; Cowley, M.; Tomczak, A.; Nanayakkara, T.; Alcorn, L.; Allen, R.; Broussard, A.; van Dokkum, P.; Forrest, B.; van Houdt, J.; Kacprzak, G. G.; Kawinwanichakij, L.; Kelson, D. D.; Lee, J.; McCarthy, P. J.; Mehrtens, N.; Monson, A.; Murphy, D.; Rees, G.; Tilvi, V.; Whitaker, K. E.

    2017-03-01

    We present the FourStar galaxy evolution survey (ZFOURGE) photometric catalogs comprising >70000 galaxies, selected from ultradeep Ks-band detection images (25.5-26.5 AB mag, 5σ, total). We use 5 near-IR medium-bandwidth filters (J1, J2, J3, Hs, Hl) as well as broad-band Ks at 1.05-2.16 micron to 25-26 AB at a seeing of ~0.5 arcsec. Each field has ancillary imaging in 26-40 filters at 0.3-8 micron. We derive photometric redshifts, rest-frame U-V and V-J colors, and stellar population properties from SED fitting. The photometric redshifts have uncertainty σz=0.010, 0.009, and 0.011 in CDFS, COSMOS and UDS, respectively, if compared with spectroscopic redshifts. A pair test indicates σz,pairs=0.01-0.02 at 1

  13. Parylene supported 20um*20um uncooled thermoelectric infrared detector with high fill factor

    NASA Astrophysics Data System (ADS)

    Modarres-Zadeh, Mohammad J.; Carpenter, Zachary S.; Rockley, Mark G.; Abdolvand, Reza

    2012-06-01

    Presented is a novel design for an uncooled surface-micromachined thermoelectric (TE) infrared (IR) detector. The detector features a P-doped polysilicon/Nichrome (Cr20-Ni80) thermocouple, which is embedded into a thin layer of Parylene-N to provide structural support. The low thermal conductivity (~0.1W/m.K), chemical resistance, and ease of deposition/patterning of Parylene-N make it an excellent choice of material for use in MEMS thermal detectors. This detector also features an umbrella-like IR absorber composed of a three layer stack of NiCr/SiN/NiCr to optimize IR absorption. The total device area is 20 um * 20 um per pixel with an absorber area of ~19 um * 19 um resulting in a fill factor of 90%. At room temperature, a DC responsivity of ~170V/W with a rise time of less than 8 ms is measured from the fabricated devices in vacuum when viewing a 500K blackbody without any concentrating optics. The dominant source of noise in thermoelectric IR detectors is typically Johnson noise when the detectors are operating in an open circuit condition. The fabricated detectors have resistances about 85KOhm which results in Johnson noise of about 38nV/Hz^0.5. The D* is calculated to be 9 * 106 cm*Hz0.5/ W. Preliminary finite element analysis indicates that the thermal conduction from the hot junction to the substrate through the TE wires is dominant ( GTE >> Gparylene) considering the fabricated dimensions of the parylene film and the TE wires. Thus, by further reducing the size of the TE wires, GTE can be decreased and hence, responsivity can be improved while the parylene film sustains the structural integrity of the cell.

  14. Activation of the Constitutive Androstane Receptor Inhibits Gluconeogenesis without Affecting Lipogenesis or Fatty Acid Synthesis in Human Hepatocytes

    PubMed Central

    Lynch, Caitlin; Pan, Yongmei; Li, Linhao; Heyward, Scott; Moeller, Timothy; Swaan, Peter W.; Wang, Hongbing

    2014-01-01

    Objective Accumulating evidence suggests that activation of mouse constitutive androstane receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic gluconeogenesis, lipogenesis, and fatty acid synthesis. However, the role of human (h) CAR in energy metabolism is largely unknown. The present study aims to investigate the effects of selective hCAR activators on hepatic energy metabolism in human primary hepatocytes (HPH). Methods Ligand-based structure-activity models were used for virtual screening of the Specs database (www.specs.net) followed by biological validation in cell-based luciferase assays. The effects of two novel hCAR activators (UM104 and UM145) on hepatic energy metabolism were evaluated in HPH. Results Real-time PCR and Western blotting analyses reveal that activation of hCAR by UM104 and UM145 significantly repressed the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, two pivotal gluconeogenic enzymes, while exerting negligible effects on the expression of genes associated with lipogenesis and fatty acid synthesis. Functional experiments show that UM104 and UM145 markedly inhibit hepatic synthesis of glucose but not triglycerides in HPH. In contrast, activation of mCAR by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a selective mCAR activator, repressed the expression of genes associated with gluconeogenesis, lipogenesis, and fatty acid synthesis in mouse primary hepatocytes, which were consistent with previous observations in mouse model in vivo. Conclusion Our findings uncover an important species difference between hCAR and mCAR in hepatic energy metabolism, where hCAR selectively inhibits gluconeogenesis without suppressing fatty acid synthesis. Implications Such species selectivity should be considered when exploring CAR as a potential therapeutic target for metabolic disorders. PMID:24878338

  15. Microwave-Assisted Extraction, Chemical Structures, and Chain Conformation of Polysaccharides from a Novel Cordyceps Sinensis Fungus UM01.

    PubMed

    Cheong, Kit-Leong; Wang, Lan-Ying; Wu, Ding-Tao; Hu, De-Jun; Zhao, Jing; Li, Shao-Ping

    2016-09-01

    Cordyceps sinensis is a well-known tonic food with broad medicinal properties. The aim of the present study was to investigate the optimization of microwave-assisted extraction (MAE) and characterize chemical structures and chain conformation of polysaccharides from a novel C. sinensis fungus UM01. Ion-exchange and gel filtration chromatography were used to purify the polysaccharides. The chemical structure of purified polysaccharide was determined through gas chromatography-mass spectrometry. Moreover, high performance size exclusion chromatography combined with refractive index detector and multiangle laser light scattering were conducted to analyze the molecular weight (Mw ) and chain conformation of purified polysaccharide. Based on the orthogonal design L9 , optimal MAE conditions could be obtained through 1300 W of microwave power, with a 5-min irradiation time at a solid to water ratio of 1:60, generating the highest extraction yield of 6.20%. Subsequently, the polysaccharide UM01-S1 was purified. The UM01-S1 is a glucan-type polysaccharide with a (1→4)-β-d-glucosyl backbone and branching points located at O-3 of Glcp with a terminal-d-Glcp. The Mw , radius of gyration (Rg ) and hydrodynamic radius (Rh ) of UM01-S1 were determined as 5.442 × 10(6)  Da, 21.8 and 20.2 nm, respectively. Using the polymer solution theory, the exponent (ν) value of the power law function was calculated as 0.38, and the shape factor (ρ = Rg /Rh ) was 1.079, indicating that UM01-S1 has a sphere-like conformation with a branched structure in an aqueous solution. These results provide fundamental information for the future application of polysaccharides from cultured C. sinensis in health and functional food area. © 2016 Institute of Food Technologists®

  16. Chromosomal rearrangements in uveal melanoma: Chromothripsis.

    PubMed

    van Poppelen, Natasha M; Yavuzyigitoglu, Serdar; Smit, Kyra N; Vaarwater, Jolanda; Eussen, Bert; Brands, Tom; Paridaens, Dion; Kiliç, Emine; de Klein, Annelies

    2018-05-04

    Uveal melanoma (UM) is the most common primary intraocular malignancy in the Western world. Recurrent mutations in GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, EIF1AX and SF3B1 are described as well as non-random chromosomal aberrations. Chromothripsis is a rare event in which chromosomes are shattered and rearranged and has been reported in a variety of cancers including UM. SNP arrays of 249 UM from patients who underwent enucleation, biopsy or endoresection were reviewed for the presence of chromothripsis. Chromothripsis was defined as ten or more breakpoints per chromosome involved. Genetic analysis of GNAQ, GNA11, BAP1, SF3B1 and EIF1AX was conducted using Sanger and next-generation sequencing. In addition, immunohistochemistry for BAP1 was performed. Chromothripsis was detected in seven out of 249 tumors and the affected chromosomes were chromosomes 3, 5, 6, 8, 12 and 13. The mean total of fragments per chromosome was 39.8 (range 12 - 116). In one UM, chromothripsis was present in two different chromosomes. GNAQ, GNA11 or CYSLTR2 mutations were present in six of these tumors and five tumors harbored a BAP1 mutation and/or lacked BAP1 protein expression by immunohistochemistry. Four of these tumors metastasized and for the fifth only short follow-up data are available. One of these metastatic tumors tumor harbored an SF3B1 mutation. No EIF1AX mutations were detected in any of the tumors. To conclude, chromothripsis is a rare event in UM, occurring in 2.8% of samples and without significant association with mutations in any of the common UM driver genes. This article is protected by copyright. All rights reserved. © 2018 Wiley Periodicals, Inc.

  17. Ultramicronized palmitoylethanolamide (PEA-um(®)) in the treatment of idiopathic pulmonary fibrosis.

    PubMed

    Di Paola, Rosanna; Impellizzeri, Daniela; Fusco, Roberta; Cordaro, Marika; Siracusa, Rosalba; Crupi, Rosalia; Esposito, Emanuela; Cuzzocrea, Salvatore

    2016-09-01

    Pulmonary fibrosis is a chronic condition characterized by progressive scarring of lung parenchyma. The aim of this study was to examine the effects of an ultramicronized preparation of palmitoylethanolamide (PEA-um(®)), an endogenous fatty acid amide, in mice subjected to idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis was induced in male mice by a single intratracheal administration of saline with bleomycin sulphate (1mg/kg body weight) in a volume of 100μL. PEA-um(®) was injected intraperitoneally at 1, 3 or 10mg/kg 1h after bleomycin instillation and daily thereafter. Animals were sacrificed after 7 and 21days by pentobarbitone overdose. One cohort of mice was sacrificed after seven days of bleomycin administration, followed by bronchoalveloar lavage and determination of myeloperoxidase activity, lung edema and histopathology features. In the 21-day cohort, mortality was assessed daily, and surviving mice were sacrificed followed by the above analyses together with immunohistochemical localization of CD8, tumor necrosis factor-α, CD4, interleukin-1β, transforming growth factor-β, inducible nitric oxide synthase and basic fibroblast growth factor. Compared to bleomycin-treated mice, animals that received also PEA-um(®) (3 or 10mg/kg) had significantly decreased weight loss, mortality, inflammation, lung damage at the histological level, and lung fibrosis at 7 and 21days. PEA-um(®) (1mg/kg) did not significantly inhibit the inflammation response and lung fibrosis. This study demonstrates that PEA-um(®) (3 and 10mg/kg) reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.

    PubMed

    Némati, Fariba; de Montrion, Catherine; Lang, Guillaume; Kraus-Berthier, Laurence; Carita, Guillaume; Sastre-Garau, Xavier; Berniard, Aurélie; Vallerand, David; Geneste, Olivier; de Plater, Ludmilla; Pierré, Alain; Lockhart, Brian; Desjardins, Laurence; Piperno-Neumann, Sophie; Depil, Stéphane; Decaudin, Didier

    2014-01-01

    Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. Consequently, regulators of apoptosis such as Bcl-2 family inhibitors may constitute an attractive approach to UM therapeutics. In this aim, we have investigated the efficacy of the Bcl-2/Bcl-XL inhibitor S44563 on 4 UM Patient-Derived Xenografts (PDXs) and derived-cell lines. Four well characterized UM PDXs were used for in vivo experiments. S44563 was administered alone or combined with fotemustine either concomitantly or after the alkylating agent. Bcl-2, Bcl-XL, and Mcl-1 expressions after S44563 administration were evaluated by immunohistochemistry (IHC). S44563 administered alone by at 50 and 100 mg/kg i.p. induced a significant tumour growth inhibition in only one xenograft model with a clear dose effect. However, when S44563 was concomitantly administered with fotemustine, we observed a synergistic activity in 3 out of the 4 tested models. In addition, S44563 administered after fotemustine induced a tumour growth delay in 2 out of 3 tested xenografts. Finally, IHC analyses showed that Bcl-2, Bcl-XL, and Mcl-1 expression were not modified after S44563 administration. The novel anti-apoptotic experimental compound S44563, despite a relative low efficacy when administered alone, increased the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine. These data support further exploration of potential therapeutic effect of Bcl-2/Bcl-xl inhibition in human UM.

  19. VizieR Online Data Catalog: Herschel FIR spectra of GOALS galaxies (Diaz-Santos+, 2017)

    NASA Astrophysics Data System (ADS)

    Diaz-Santos, T.; Armus, L.; Charmandaris, V.; Lu, N.; Stierwalt, S.; Stacey, G.; Malhotra, S.; van der Werf, P. P.; Howell, J. H.; Privon, G. C.; Mazzarella, J. M.; Goldsmith, P. F.; Murphy, E. J.; Barcos-Munoz, L.; Linden, S. T.; Inami, H.; Larson, K. L.; Evans, A. S.; Appleton, P.; Iwasawa, K.; Lord, S.; Sanders, D. B.; Surace, J. A.

    2018-04-01

    We have obtained FIR spectroscopic observations for 200 luminous infrared galaxies (LIRG) systems from the Great Observatories All-Sky LIRG Survey (GOALS; Armus+ 2009PASP..121..559A) using the Integral Field Spectrometer (IFS) of the PACS instrument on board Herschel. Since some targets contain multiple components, there are 241 individual galaxies with available spectra in at least one emission line. Most of the data were collected as part of our OT1 and OT2 programs (OT1larmus1, OT2larmus1; P.I.: L. Armus), accounting for more than 200hr of observing time in total. Additional observations that are publicly available in the Herschel archive were included from various projects. The main programs from where these complementary data were gathered are KPGTesturm1 (P.I.: E. Sturm), KPOTpvanderw1 (PI: P. van der Werf), and OT1dweedman1 (P.I.: D. Weedman). The IFS on PACS is able to perform simultaneous spectroscopy in the 51-73 or 70-105um and the 102-210um ranges. In addition to the PACS/IFS spectra, we obtained observations of the [NII]205 emission line using the SPIRE FTS for 121 galaxies in the GOALS sample (Lu+ 2017, J/ApJS/230/1 ; OT1nlu1; P.I.: N. Lu). As part of the Spitzer GOALS legacy program, all galaxies observed with Herschel/PACS have available Spitzer/IRS low-resolution, R~60-120 (SL module: 5.2-14.5um; LL module: 14-38um), and medium-resolution, R~600 (SH module: 9.9-19.6um; LH module: 18.7-37.2um), slit spectroscopy. (3 data files).

  20. University of Malaya dental students' attitudes towards communication skills learning: implications for dental education.

    PubMed

    Nor, Nor Azlida M; Yusof, Zamros Y M; Shahidan, Mohd Noor F M

    2011-12-01

    The Ministry of Higher Education in Malaysia has called for the implementation of a soft skills module in all public universities in Malaysia. In response to this and as part of curriculum development efforts for a new integrated program for 2011, a study was undertaken to improve the University of Malaya (UM) Faculty of Dentistry's communication skills course. One of the study objectives was to investigate dental students' attitudes towards communication skills learning and the association between their attitudes and demographic and education-related characteristics. A cross-sectional survey--using a self-administered twenty-four-item adapted Communication Skills Attitude Scale (CSAS) that contained both positive (PAS) and negative (NAS) attitude subscales--was carried out targeting all final-year dental students at the UM and the Universiti Kebangsaan Malaysia (UKM). A total of 148 students completed the survey, yielding a response rate of 88.1 percent. Overall, UKM students had significantly more positive attitudes towards communication skills learning (PAS score: mean=48.69, SD=4.48, p<0.001) than UM students (mean=46.03, SD=4.22). There was no statistically significant difference in negative attitudes between the two groups. UKM students with more positive attitudes tended to be female (p<0.05). UM students with more negative attitudes perceived themselves as poor communicators (p<0.05), and UKM students with more negative attitudes tended to have poor English proficiency (p<0.05). This study found that both UM and UKM final-year dental students have positive and negative attitudes towards learning communication skills. These attitudes were significantly associated with certain background and education-related attributes. Outcomes of this study served as a valuable guide in strengthening the communication skills course for the UM's new, integrated dental curriculum.

  1. Attitude and knowledge about foot health: a spanish view.

    PubMed

    López-López, Daniel; García-Mira, Ricardo; Palomo-López, Patricia; Sánchez-Gómez, Rubén; Ramos-Galván, José; Tovaruela-Carrión, Natalia; García-Sánchez, Matilde

    2017-04-06

    to explore attitudes towards patients' self-reported data about foot health-related beliefs from a behavioural and attitudinal perspective. a sample of 282 participants of a mean age of 39.46 ± 16.026 came to a health centre where self-reported demographic, clinical characteristics and beliefs relating to foot health data were registered, informants' completed all the stages of the research process. the results of the analysis revealed an 8-factor factorial structure based on (1) podiatric behaviours, (2) the intention to carry out protective behaviour, (3) attitudinal beliefs, (4) normative beliefs, (5) needs, (6) apathy, (7) self-care, and (8) the general perception of foot health. They all explained 62.78% of the variance, and were considered as independent variables in a regression analysis to determine which provided the best explanations for the importance attributed to foot health. the participants in the study revealed a positive attitude in relation to foot health care and responsible behaviour. explorar as atitudes em relação aos dados auto-relatados dos pacientes sobre crenças relacionadas à saúde do pé, desde uma perspectiva comportamental e atitudinal. uma amostra de 282 participantes com idade média de 39,46 ± 16,026 chegaram a um centro de saúde onde foram registradas características demográficas, clínicas e crenças auto-relatadas referentes a dados de saúde do pé, os quais completaram todas as fases do processo de pesquisa. os resultados da análise revelaram uma estrutura fatorial de 8 fatores baseada em (1) comportamentos podiátricos, (2) a intenção de realizar comportamentos protetores, (3) crenças atitudinais, (4) crenças normativas, (6) apatia, (7) autocuidado, e (8) a percepção geral da saúde do pé. Todos eles explicaram 62,78% da variância e foram considerados como variáveis ​​independentes em uma análise de regressão para determinar quais forneceram as melhores explicações para a importância atribuída à saúde do pé. os participantes do estudo revelaram uma atitude positiva em relação à saúde do pé e comportamento responsável. explorar las actitudes relacionadas con datos autoinformados sobre las creencias de la salud del pie desde una perspectiva actitudinal. una muestra de 282 participantes edad media 39.46 ± 16.026 acudieron a un centro de salud donde se registraron datos autoinformados de las características demográficas, características clínicas y creencias relacionadas con la salud del pie, completándose todas las etapas del proceso de investigación. los resultados del análisis revelaron una estructura factorial de 8 factores basado en (1) conductas podológicas, (2) la intención de llevar a cabo una conducta de protección, (3) las creencias actitudinales, (4) las creencias normativas, (5) las necesidades, (6) la apatía, (7) el autocuidado, y (8) la percepción general de salud podal. Todos ellos explicaron un 62,78% de la varianza, y fueron considerados como variables independientes en una ecuación de regresión para determinar cuáles de ellos explicaban mejor la importancia atribuida a la salud del pie. los participantes en el estudio revelaron una actitud positiva en relación al cuidado de la salud del pie y al comportamiento responsable.

  2. 406 E Grand, October 2010, Lindsay Light Radiological Survey

    EPA Pesticide Factsheets

    The field gamma measurements within the excavation and the spoil materials generated during the excavation process did not exceed the respective threshold values previously stated and ranged from a minim um of 1, 120 cpm to a maxim um of 6,640 cpm.

  3. VizieR Online Data Catalog: SCUBA-2 high-redshift galaxies sample (Barger+, 2014)

    NASA Astrophysics Data System (ADS)

    Barger, A. J.; Cowie, L. L.; Chen, C.-C.; Owen, F. N.; Wang, W.-H.; Casey, C. M.; Lee, N.; Sanders, D. B.; Williams, J. P.

    2017-05-01

    We obtained 25.4 hr of observations on the CDF-N with SCUBA-2 on the JCMT during observing runs in 2012 and 2013. The data were obtained using a mixture of scanning modes and under a variety of weather conditions. Using the CV Daisy scanning mode (detailed information about the SCUBA-2 scan patterns can be found in Holland et al. 2013MNRAS.430.2513H), we obtained a 2.2 hr observation in band 1 weather (225 GHz opacity<0.05) and a 16.5 hr observation in band 2 weather (225 GHz opacity ~0.05-0.08). We also obtained a 6.7 hr observation in band 2 weather using the pong-900 scanning mode. While SCUBA-2 observes at both 450 um and 850 um simultaneously, there are too few sources directly detected at 450 um in our data to be interesting. Thus, we only use the 850 um data in our subsequent analysis. (1 data file).

  4. Utilization management affects health care practices at Walter Reed Army Medical Center: analytical methods applied to decrease length of stay and assign appropriate level of care.

    PubMed

    Phillips, J S; Hamm, C K; Pierce, J R; Kussman, M J

    1999-12-01

    The Department of Defense has embraced utilization management (UM) as an important tool to control and possibly decrease medical costs. Budgetary withholds have been taken by the Office of the Assistant Secretary of Defense (Health Affairs) to encourage the military services to implement UM programs. In response, Walter Reed Army Medical Center implemented a UM program along with other initiatives to effect changes in the delivery of inpatient care. This paper describes this UM program and other organizational initiatives, such as the introduction of new levels of care in an attempt to effect reductions in length of stay and unnecessary admissions. We demonstrate the use of a diversity of databases and analytical methods to quantify improved utilization and management of resources. The initiatives described significantly reduced hospital length of stay and inappropriate inpatient days. Without solid command and clinical leadership support and empowerment of the professional staffs, these significant changes and improvements could not have occurred.

  5. Differences in Hospital Managers’, Unit Managers’, and Health Care Workers’ Perceptions of the Safety Climate for Respiratory Protection

    PubMed Central

    Peterson, Kristina; Rogers, Bonnie M. E.; Brosseau, Lisa M.; Payne, Julianne; Cooney, Jennifer; Joe, Lauren; Novak, Debra

    2017-01-01

    This article compares hospital managers’ (HM), unit managers’ (UM), and health care workers’ (HCW) perceptions of respiratory protection safety climate in acute care hospitals. The article is based on survey responses from 215 HMs, 245 UMs, and 1,105 HCWs employed by 98 acute care hospitals in six states. Ten survey questions assessed five of the key dimensions of safety climate commonly identified in the literature: managerial commitment to safety, management feedback on safety procedures, coworkers’ safety norms, worker involvement, and worker safety training. Clinically and statistically significant differences were found across the three respondent types. HCWs had less positive perceptions of management commitment, worker involvement, and safety training aspects of safety climate than HMs and UMs. UMs had more positive perceptions of management’s supervision of HCWs’ respiratory protection practices. Implications for practice improvements indicate the need for frontline HCWs’ inclusion in efforts to reduce safety climate barriers and better support effective respiratory protection programs and daily health protection practices. PMID:27056750

  6. Differences in Hospital Managers', Unit Managers', and Health Care Workers' Perceptions of the Safety Climate for Respiratory Protection.

    PubMed

    Peterson, Kristina; Rogers, Bonnie M E; Brosseau, Lisa M; Payne, Julianne; Cooney, Jennifer; Joe, Lauren; Novak, Debra

    2016-07-01

    This article compares hospital managers' (HM), unit managers' (UM), and health care workers' (HCW) perceptions of respiratory protection safety climate in acute care hospitals. The article is based on survey responses from 215 HMs, 245 UMs, and 1,105 HCWs employed by 98 acute care hospitals in six states. Ten survey questions assessed five of the key dimensions of safety climate commonly identified in the literature: managerial commitment to safety, management feedback on safety procedures, coworkers' safety norms, worker involvement, and worker safety training. Clinically and statistically significant differences were found across the three respondent types. HCWs had less positive perceptions of management commitment, worker involvement, and safety training aspects of safety climate than HMs and UMs. UMs had more positive perceptions of management's supervision of HCWs' respiratory protection practices. Implications for practice improvements indicate the need for frontline HCWs' inclusion in efforts to reduce safety climate barriers and better support effective respiratory protection programs and daily health protection practices. © 2016 The Author(s).

  7. Serious game development as a strategy for health promotion and tackling childhood obesity.

    PubMed

    Dias, Jéssica David; Mekaro, Marcelo Shinyu; Cheng Lu, Jennifer Kaon; Otsuka, Joice Lee; Fonseca, Luciana Mara Monti; Zem-Mascarenhas, Silvia Helena

    2016-08-15

    to develop and assess a serious game on healthy eating and physical activity to promote health and tackle childhood obesity. a descriptive, applied and methodological study.For the development of the game, the following steps were taken: conceptualization, pre-production with the development of the game documentation, prototyping, production and assessment of thecomputer and health experts. a prototype has been developed up to beta version. The game was positively assessed both in terms of gameplay and mechanics, and in relation to the content presented, standing out as a powerful strategy for health promotion. The information from the assessment phase contributed to the settings in the software in order to make it available in the future for the target population of this research. The greatest advantage of the proposed game is the fact that it is an open educational resource. the expert assessments showed that the game has great educational potential and it is considered suitable for future application to the target audience.The serious game can become a technological teaching resource available for use in schools and health facilities, and can also be reused for the production of other educational games by accessing its source code. desenvolver e avaliar um serious game (Jogo sério) sobre alimentação saudável e exercício físico para promoção da saúde e auxílio ao enfrentamento da obesidade infantil. estudo descritivo, aplicado e metodológico. Para o desenvolvimento do jogo, foram percorridas as seguintes etapas: conceituação, pré-produção com desenvolvimento da documentação do jogo, prototipagem, produção e avaliação de especialistas de computação e saúde. desenvolveu-se um protótipo até a versão beta. O jogo foi avaliado positivamente tanto em relação à jogabilidade e mecânica, quanto em relação ao conteúdo apresentado, destacando-se como uma estratégia potente para a promoção de saúde. As informações oriundas da fase de avaliação serviram de subsídio para adequações no software com a finalidade de disponibilizá-lo futuramente à população alvo da pesquisa. O grande diferencial do jogo proposto é o fato do mesmo ser um recurso educacional aberto. as avaliações com especialistas demonstraram que o jogo tem grande potencial educacional e considerado adequado para a aplicação futura com o público-alvo. O serious game pode ser um recurso didático tecnológico acessível para uso em escolas e unidades de saúde, além de poder ser reutilizado para a produção de outros jogos educacionais através do acesso de seu código fonte. desarrollar y evaluar un serious game (Juego serio) sobre alimentación saludable y ejercicio físico para la promoción de la salud y ayudar en el enfrentamiento de la obesidad infantil. estudio descriptivo, aplicado y metodológico. Para el desarrollo del juego, se iniciaron los siguientes pasos: conceptualización, pre-producción con el desarrollo de la documentación del juego, creación de prototipos, producción y evaluación por expertos informáticos y en salud. un prototipo se ha desarrollado hasta la versión beta. El juego se evaluó positivamente tanto en términos de jugabilidad y mecánica como en relación con el contenido presentado, destacándose como una poderosa estrategia para la promoción de la salud. La información de la fase de evaluación contribuyó a los ajustes en el software con el fin de que esté disponible en el futuro para la población objetivo de esa investigación. La gran vantaja del juego propuesto es el hecho de que es un recurso educativo abierto. las evaluaciones de los expertos mostraron que el juego tiene un gran potencial educativo y es considerado adecuado para la aplicación futura para el público objetivo. El serious game puede convertirse en un recurso para la enseñanza tecnológica disponible para uso en las escuelas y en los centros de salud, y también puede ser reutilizado para la producción de otros juegos educativos mediante el acceso a su código fuente.

  8. Unconsummated marriages: a separate and different clinical entity.

    PubMed

    Gindin, Leon Roberto; Resnicoff, Diana

    2002-01-01

    We bring our experience in the treatment of unconsummated marriages (UM). We postulate that it is an independent clinical entity. Since 1991, 199 couples with UM have sought treatment in our center in Buenos Aires. A new approach to this problem is based on an intensive treatment session that lasts a whole day and a pledge to pay only if therapy succeeds. The outcome was a success (97%) with coitus consummation. We make a long-term follow up. The advantages are the brevity of the treatment and lack of desertions. We postulate that UM cannot be approached with an individual perspective or with the usual psychotherapy techniques.

  9. NUTRIENT LIMITATION OF PHYTOPLANKTON GROWTH AND PHYSIOLOGY IN A SUBTROPICAL ESTUARY (PENSACOLA BAY, FL)

    EPA Science Inventory

    Phytoplankton nutrient limitation was studied in a sub-estuary of lower Pensacola Bay using several techniques. Results for <5 um and . 5 um phytoplankton were similar. Nutrient-addition bioassays indicated year-round nutrient limitation, in contrast to seasonal patterns often ...

  10. Unit 5, STA. 50+00+RB, retaining wall at First U.M. Churchdetail ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Unit 5, STA. 50+00+RB, retaining wall at First U.M. Church-detail - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

  11. DIRECT-DEPOSITION INFRARED SPECTROMETRY WITH GAS AND SUPERCRITICAL FLUID CHROMATOGRAPHY

    EPA Science Inventory

    A direct-deposition Fourier transform infrared (FT-IR) system has been evaluated for applicability to gas chromatography (GC) and supercritical fluid chromatography (SFC) of environmental analytes. A 100-um i.d. fused-silica transfer line was used for GC, and a 50-um transfer lin...

  12. Linguistic camouflage in girls with autism spectrum disorder.

    PubMed

    Parish-Morris, Julia; Liberman, Mark Y; Cieri, Christopher; Herrington, John D; Yerys, Benjamin E; Bateman, Leila; Donaher, Joseph; Ferguson, Emily; Pandey, Juhi; Schultz, Robert T

    2017-01-01

    Autism spectrum disorder (ASD) is diagnosed more frequently in boys than girls, even when girls are equally symptomatic. Cutting-edge behavioral imaging has detected "camouflaging" in girls with ASD, wherein social behaviors appear superficially typical, complicating diagnosis. The present study explores a new kind of camouflage based on language differences. Pauses during conversation can be filled with words like UM or UH, but research suggests that these two words are pragmatically distinct (e.g., UM is used to signal longer pauses, and may correlate with greater social communicative sophistication than UH). Large-scale research suggests that women and younger people produce higher rates of UM during conversational pauses than do men and older people, who produce relatively more UH. Although it has been argued that children and adolescents with ASD use UM less often than typical peers, prior research has not included sufficient numbers of girls to examine whether sex explains this effect. Here, we explore UM vs. UH in school-aged boys and girls with ASD, and ask whether filled pauses relate to dimensional measures of autism symptom severity. Sixty-five verbal school-aged participants with ASD (49 boys, 16 girls, IQ estimates in the average range) participated, along with a small comparison group of typically developing children (8 boys, 9 girls). Speech samples from the Autism Diagnostic Observation Schedule were orthographically transcribed and time-aligned, with filled pauses marked. Parents completed the Social Communication Questionnaire and the Vineland Adaptive Behavior Scales. Girls used UH less often than boys across both diagnostic groups. UH suppression resulted in higher UM ratios for girls than boys, and overall filled pause rates were higher for typical children than for children with ASD. Higher UM ratios correlated with better socialization in boys with ASD, but this effect was driven by increased use of UH by boys with greater symptoms. Pragmatic language markers distinguish girls and boys with ASD, mirroring sex differences in the general population. One implication of this finding is that typical-sounding disfluency patterns (i.e., reduced relative UH production leading to higher UM ratios) may normalize the way girls with ASD sound relative to other children, serving as "linguistic camouflage" for a naïve listener and distinguishing them from boys with ASD. This first-of-its-kind study highlights the importance of continued commitment to understanding how sex and gender change the way that ASD manifests, and illustrates the potential of natural language to contribute to objective "behavioral imaging" diagnostics for ASD.

  13. Telescópio de patrulhamento solar em 12 GHz

    NASA Astrophysics Data System (ADS)

    Utsumi, F.; Costa, J. E. R.

    2003-08-01

    O telescópio de patrulhamento solar é um instrumento dedicado à observação de explosões solares com início de suas operações em janeiro de 2002, trabalhando próximo ao pico de emissão do espectro girossincrotrônico (12 GHz). Trata-se de um arranjo de três antenas concebido para a detecção de explosões e determinação em tempo real da localização da região emissora. Porém, desde sua implementação em uma montagem equatorial movimentada por um sistema de rotação constante (15 graus/hora) o rastreio apresentou pequenas variações de velocidade e folgas nas caixas de engrenagens. Assim, tornou-se necessária a construção de um sistema de correção automática do apontamento que era de fundamental importância para os objetivos do projeto. No segundo semestre de 2002 empreendemos uma série de tarefas com o objetivo de automatizar completamente o rastreio, a calibração, a aquisição de dados, controle de ganhos, offsets e transferência dos dados pela internet através de um projeto custeado pela FAPESP. O rastreio automático é realizado através de um inversor que controla a freqüência da rede de alimentação do motor de rastreio podendo fazer micro-correções na direção leste-oeste conforme os radiômetros desta direção detectem uma variação relativa do sinal. Foi adicionado também um motor na direção da declinação para correção automática da variação da direção norte-sul. Após a implementação deste sistema a precisão do rastreio melhorou para um desvio máximo de 30 segundos de arco, o que está muito bom para este projeto. O Telescópio se encontra em funcionamento automático desde março de 2003 e já conta com várias explosões observadas após a conclusão desta fase de automação. Estamos apresentando as explosões mais intensas do período e com as suas respectivas posições no disco solar.

  14. Evaluation of Unified Model Microphysics in High-resolution NWP Simulations Using Polarimetric Radar Observations

    NASA Astrophysics Data System (ADS)

    Johnson, Marcus; Jung, Youngsun; Dawson, Daniel; Supinie, Timothy; Xue, Ming; Park, Jongsook; Lee, Yong-Hee

    2018-07-01

    The UK Met Office Unified Model (UM) is employed by many weather forecasting agencies around the globe. This model is designed to run across spatial and time scales and known to produce skillful predictions for large-scale weather systems. However, the model has only recently begun running operationally at horizontal grid spacings of ˜1.5 km [e.g., at the UK Met Office and the Korea Meteorological Administration (KMA)]. As its microphysics scheme was originally designed and tuned for large-scale precipitation systems, we investigate the performance of UM microphysics to determine potential inherent biases or weaknesses. Two rainfall cases from the KMA forecasting system are considered in this study: a Changma (quasi-stationary) front, and Typhoon Sanba (2012). The UM output is compared to polarimetric radar observations in terms of simulated polarimetric radar variables. Results show that the UM generally underpredicts median reflectivity in stratiform rain, producing high reflectivity cores and precipitation gaps between them. This is partially due to the diagnostic rain intercept parameter formulation used in the one-moment microphysics scheme. Model drop size is generally both underand overpredicted compared to observations. UM frozen hydrometeors favor generic ice (crystals and snow) rather than graupel, which is reasonable for Changma and typhoon cases. The model performed best with the typhoon case in terms of simulated precipitation coverage.

  15. International Space Station Urine Monitoring System Functional Integration and Science Testing

    NASA Technical Reports Server (NTRS)

    Rodriquez, Branelle R.; Broyan, James Lee, Jr.

    2011-01-01

    Exposure to microgravity during human spaceflight needs to be better understood as the human exploration of space requires longer duration missions. It is known that long term exposure to microgravity causes bone loss. Measuring the calcium and other metabolic byproducts in a crew member s urine can evaluate the effectiveness of bone loss countermeasures. The International Space Station (ISS) Urine Monitoring System (UMS) is an automated urine collection device designed to collect urine, separate the urine and air, measure the void volume, and allow for syringe sampling. Accurate measuring and minimal cross-contamination is essential to determine bone loss and the effectiveness of countermeasures. The ISS UMS provides minimal cross-contamination (<0.7 mL urine) and has volume accuracy of 2% between 100 to 1000 mL urine voids. Designed to provide a non-invasive means to collect urine samples from crew members, the ISS UMS operates in-line with the Node 3 Waste and Hygiene Compartment (WHC). The ISS UMS has undergone modifications required to interface with the WHC, including material changes, science algorithm improvements, and software platform revisions. Integrated functional testing was performed to determine the pressure drop, air flow rate, and the maximum amount of fluid capable of being discharged from the UMS to the WHC. This paper will detail the results of the science and the functional integration tests.

  16. Darwin als Sehhilfe für die Psychologie - Evolutionspsychologie

    NASA Astrophysics Data System (ADS)

    Schwab, Frank

    Im Folgenden geht es um Einäugige, stereoskopisches Sehen, weite und enge Horizonte, Monokel und Sonnenbrillen. Der Beitrag versucht die Metapher des Sehens und der Sehhilfen anzuwenden, um so zu verdeutlichen, welchen Gewinn die herkömmliche Psychologie durch die Verwendung einer Darwin'schen Brille erlangen kann.

  17. Application of LEED (trademark) and SPiRiT to a Proposed Building Design

    DTIC Science & Technology

    2003-03-01

    TOTAL AREA S CAT ARLOC INSTALLATION NO CODE C QTY UM OCPD F CODE 1) 24004 Aberdeen Provi E1890...ARLOC INSTALLATION NO CODE C QTY UM OCPD F CODE 1) 24004 Aberdeen Provi E3832 31010 P 13,000 SF 13,000 R

  18. Evolution and Persistence of 5-um Hot Spots at the Galileo Probe entry Latitude

    NASA Technical Reports Server (NTRS)

    Fisher, B. M.

    1997-01-01

    We present a study on the longtudinal locations, morphology and evolution of the 5-um hot spots at 6.5 deg. N latitude (planetocentric), from an extensive IRTF-NSFCAM data set spanning more that 3 years, which includes the date of the Galileo Probe entry.

  19. Antimalarial and antileishmanial activities of phytophenolics and their synthetic analogues

    USDA-ARS?s Scientific Manuscript database

    Thirty-seven phytophenolics and their synthetic analogues were evaluated for activity against two protozoal pathogens, Leishmania donovani and Plasmodium falciparum (D6 and W2 clone), respectively. 4,6-Dimethoxyaurone demonstrated the highest activity with IC50 values of 13.2 uM and 16.9 uM against ...

  20. Linear Stability of Self-Similar Flow: 1. Isothermal Cylindrical Implosion and Expansion.

    DTIC Science & Technology

    1978-03-01

    Attn: J. Tachon N. Trocheris C. Z4ercier R. B. Paris 3. Centro di Studio sui Gas lonizzati Univereita di Pe4ova 6/a Via Gre.denigo 35100 Padova, Italia...fur Plasma Physics 8046 Garching bet ?~rncben West Germany Attn: D. Biskamp K. Von Hagenow Horst Pacher chodura V. Schneider D. Pfirsch 10. Siberian

  1. Technology Usage among Community College Faculty in First-Time-in-College Classes: A Call to Standardization

    ERIC Educational Resources Information Center

    Goomas, David T.

    2013-01-01

    Technology in higher education has played an increasingly dramatic role, particularly on community college campuses, with emphasis on how to provide better services to students via the use of technology. This report examines the challenge for faculty teaching first-time-in-college (FTIC) classes at El Centro College of the Dallas County Community…

  2. Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

    PubMed

    Avila, Jesus; Hernandez, Felix; Wandosell, Francisco; Lucas, Jose J; Esteban, Jose A; Ledesma, M Dolores; Bullido, Maria J

    2010-01-01

    One important aspect of studies carried out at the Center for Molecular Biology "Severo Ochoa" is focused on basic aspects of Alzheimer's disease, mainly the search for suitable therapeutic targets for this disorder. Several groups at the Center are involved in these studies, and, in this spotlight, the work they are carrying out will be described.

  3. Directrices para la Creacion del Centro Nacional de Informacion y Documentacion (Guidelines for the Creation of a National Information and Documentation Center).

    ERIC Educational Resources Information Center

    Menda Behrens, Eduardo

    This document discusses background information and guidelines for the creation of a national information and documentation center for the dissemination of scientific and technological information. The study first reports on information services in several other countries and the need for an information center in Venezuela; included are…

  4. Servicios del Centro de Soluciones Para la Energia Limpia (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2014-05-01

    This is the Spanish translation of the Clean Energy Solutions Center Services fact sheet. The Clean Energy Solutions Center (Solutions Center) helps governments, advisors and analysts create policies and programs that advance the deployment of clean energy technologies. The Solutions Center partners with international organizations to provide online training, expert assistance, and technical resources on clean energy policy.

  5. GEONETCast Americas

    Science.gov Websites

    -channel CIIFEN Centro Internacional para la Investigación del Fenómeno de El Niño / International Conocimiento y Uso de la Biodiversidad / National Commission for Knowledge and Use of Biodiversity Sub-channel Center for the Investigation of the El Niño Phenomenon Sub-channel CMACast Regional GEOENTCast Component

  6. Revised Programme Proposal for the Swedish-Portuguese Cooperation in the Field of Scientific and Technical Information and Documentation.

    ERIC Educational Resources Information Center

    Hjerppe, Roland; And Others

    Due to complications that arose after the change of government in Portugal, staffing problems at the Portuguese Centro de Documentacao Cientifica e Tecnica (CDCT) were not resolved until March 1977. As a result, the cooperative program between Portugal and Sweden for scientific and technical information and documentation fell behind its original…

  7. Physical and Chemical Data Report.

    DTIC Science & Technology

    1980-06-15

    FISHERIES RESEARCH AND DEVELOPMENT BIBLIOTECA . INSTITUTO BEL MAR AGENCY APARTADO POSTAL 22 16-2KA, HARNANG )ONG CALLAO YOUNGDO-KU SUSAN 606 PERU KOREA... BIBLIOTECA SUBSCRIPTION DEPARTMENT INSTITUTO NACIONAL BE PESCA NEW SOUTH MALES GOVERNMENT OFFICES CENTRO BE INVESTIGACION PESQUERA 66 STRAND APARTADO...POSTAL 1366 LONDON, UC2N 5LZ, ENGLAND ENSERAA, BAJA CALIFORNIA UNITED KINGDOM Mexico LIBRARY BIBLIOTECA FISHERIES LABORATORY UNIAD BE CIENCIAS MARINAS

  8. The International Symposium on Applied Military Psychology (18th) Held at London, England on 21-25 June 1982,

    DTIC Science & Technology

    1982-11-30

    just this past year the separate and indeed they often went directly to women’s services were legally abolished, their bunks to recuperate after a work...5* Rep. Sanitfi A.M. Centro Studie Ricerche Medicina Aeronauticae Spaziale Viale P. Gobetti, 2-2A 00185 Roma Dr. Massimiliano Stracca Ispettorato

  9. Photoproduction of charm particles at Fermilab

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cumalat, John P.

    A brief description of the Fermilab Photoproduction Experiment E831 or FOCUS is presented. The experiment concentrates on the reconstruction of charm particles. The FOCUS collaboration has participants from several Central American and Latin American institutions; CINVESTAV and Universidad Autonoma de Puebla from Mexico, University of Puerto Rico from the United States, and Centro Brasileiro de Pesquisas Fisicas in Rio de Janeiro from Brasil.

  10. Imagining the Mexican Immigrant Worker: (Inter)Nationalism, Identity, and Insurgency in the Chicano Movement in Los Angeles.

    ERIC Educational Resources Information Center

    Chavez, Ernesto

    2000-01-01

    Traces the history of two organizations of the 1970s Chicano Movement: the Committee to Free Los Tres and the Centro de Accion Social Autonomo (CASA). Discusses their Marxist ideology, notion of Chicano cultural nationalism, involvement of college students and other youth, campaigns supporting immigrant workers' rights and affirmative action at…

  11. An Improved Inventory Control Model for the Brazilian Navy Supply System

    DTIC Science & Technology

    2001-12-01

    Portuguese Centro de Controle de Inventario da Marinha, the Brazilian Navy Inventory Control Point (ICP) developed an empirical model called SPAADA...NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS Approved for public release; distribution is unlimited AN IMPROVED INVENTORY CONTROL ...AN IMPROVED INVENTORY CONTROL MODEL FOR THE BRAZILIAN NAVY SUPPLY SYSTEM Contract Number Grant Number Program Element Number Author(s) Moreira

  12. Editorial

    NASA Astrophysics Data System (ADS)

    Boerma, Dirk O.; Climent-Font, Aurelio; Respaldiza, Miguel Ángel

    2006-08-01

    The IBA conference has taken place in different countries from all over the world. It started in the United States in 1973, and since then has been held biennially without interruption, becoming the reference meeting on ion beam analysis and related methods and techniques. In its 17th edition, two Spanish laboratories, one from the Universidad de Sevilla and one from the Universidad Autónoma de Madrid had the honour and responsibility of organizing the conference. These two laboratories are, so far, the only ones in the country equipped with accelerators dedicated to ion beam analysis; the Centro Nacional de Aceleradores (CNA) in Seville and the Centro de Micro-Análisis de Materiales (CMAM) in Madrid. We took up this task enthusiastically, conscious that Spain has only very recently been equipped with IBA techniques and that this event would highlight to the scientific community of our country the importance and involvement of IBA techniques in new scientific and technological developments. The conference was held at the Melia Sevilla Hotel in Seville, Spain from 26 June-1 July 2005. This special issue of Nuclear Instruments and Methods in Physics Research B contains the published proceedings of the conference.

  13. Integrated passive/active vibration absorber for multi-story buildings

    NASA Technical Reports Server (NTRS)

    Lee-Glauser, Gina J.; Ahmadi, Goodarz; Horta, Lucas G.

    1995-01-01

    Passive isolator, active vibration absorber, and an integrated passive/active (hybrid) control are studied for their effectiveness in reducing structural vibration under seismic excitations. For the passive isolator, a laminated rubber bearing base isolator which has been studied and used extensively by researchers and seismic designers is considered. An active vibration absorber concept, which can provide guaranteed closed-loop stability with minimum knowledge of the controlled system, is used to reduce the passive isolator displacement and to suppress the top floor vibration. A three-story building model is used for the numerical simulation. The performance of an active vibration absorber and a hybrid vibration controller in reducing peak structural responses is compared with the passively isolated structural response and with absence of vibration control systems under the N00W component of El Centro 1940 and N90W component of the Mexico City earthquake excitation records. The results show that the integrated passive/active vibration control system is most effective in suppressing the peak structural acceleration for the El Centro 1940 earthquake when compared with the passive or active vibration absorber alone. The active vibration absorber, however, is the only system that suppresses the peak acceleration of the structure for the Mexico City 1985 earthquake.

  14. [Calf circumference and its association with gait speed in elderly participants at Peruvian Naval Medical Center].

    PubMed

    Díaz Villegas, Gregory Mishell; Runzer Colmenares, Fernando

    2015-01-01

    To evaluate the association between calf circumference and gait speed in elderly patients 65 years or older at Geriatric day clinic at Peruvian Centro Médico Naval. Cross-sectional, retrospective study. We assessed 139 participants, 65 years or older at Peruvian Centro Médico Naval including calf circumference, gait speed and Short Physical Performance Battery. With bivariate analyses and logistic regression model we search for association between variables. The age mean was 79.37 years old (SD: 8.71). 59.71% were male, the 30.97% had a slow walking speed and the mean calf circumference was 33.42cm (SD: 5.61). After a bivariate analysis, we found a calf circumference mean of 30.35cm (SD: 3.74) in the slow speed group and, in normal gait group, a mean of 33.51cm (SD: 3.26) with significantly differences. We used logistic regression to analyze association with slow gait speed, founding statistically significant results adjusting model by disability and age. Low calf circumference is associated with slow speed walk in population over 65 years old. Copyright © 2014. Published by Elsevier Espana.

  15. Spin re-orientation in heavy fermion system α - YbAl1 - x FexB4

    NASA Astrophysics Data System (ADS)

    Wu, Shan; Broholm, C.; Kuga, K.; Suzuki, Shintaro; Nakatsuji, S.; Mourigal, M.; Stone, M.; Tian, Wei; Qiu, Y.; Rodriguez-Rivera, Jose

    Non centro-symmetric α - YbAlB4 has a heavy Fermi liquid ground state and shares many characteristics with centro-symmetric β - YbAlB4 . Both isomorphs display intermediate valence, associated with a fluctuation scale of T0 = 200 K and a Kondo lattice scale of T* = 8 K. Unlike β - YbAlB4 , α - YbAlB4 is at the boundary of a transition from a Fermi liquid metallic state to an antiferromagnetic (AFM) insulating state, driven by Fe substitution of Al. Magnetization and specific heat measurements reveal two different antiferromagnetic phases with TN = 9 K and TN = 2 K for Fe concentration above and below x =0.07. We report single crystal neutron scattering experiments on Fe doped YbAlB4 with x =0.035 and x =0.125. While the ordering wave vector is identical, k -> = (1 , 0 , 0) , the spin orientation switches from c to a with increasing Fe concentration. This suggests different anisotropic hybridization between 4f and conduction electrons that we confirmed by determining the crystal field levels. Supported by DOE, BES through DE-FG02-08ER46544.

  16. Asociación de Hemato-Oncología Pediátrica de Centro América (AHOPCA): a model for sustainable development in pediatric oncology.

    PubMed

    Barr, Ronald D; Antillón Klussmann, Federico; Baez, Fulgencio; Bonilla, Miguel; Moreno, Belgica; Navarrete, Marta; Nieves, Rosa; Peña, Armando; Conter, Valentino; De Alarcón, Pedro; Howard, Scott C; Ribeiro, Raul C; Rodriguez-Galindo, Carlos; Valsecchi, Maria Grazia; Biondi, Andrea; Velez, George; Tognoni, Gianni; Cavalli, Franco; Masera, Giuseppe

    2014-02-01

    Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnership between a Central American consortium--Asociación de Hemato-Oncología Pediátrica de Centro América (AHOPCA)--and institutions in Europe and North America provides a striking example of such a twinning program. The demonstrable success of this endeavor offers a model for improving the health outcomes of children with cancer worldwide. As this remarkable enterprise celebrates its 15th anniversary, it is appropriate to reflect on its origin, subsequent growth and development, and the lessons it provides for others embarking on or already engaged in similar journeys. Many challenges have been encountered and not all yet overcome. Commitment to the endeavor, collaboration in its achievements and determination to overcome obstacles collectively are the hallmarks that stamp AHOPCA as a particularly successful partnership in advancing pediatric oncology in the developing world. © 2013 Wiley Periodicals, Inc.

  17. Design of a Heliostat for Centro de Investigaciones de Astronomía (CIDA)

    NASA Astrophysics Data System (ADS)

    Dávila, L. E.; Barboza, S. J.; Sánchez, G. A.; Della Prugna, F.; Cova, J.; Provenzano, S. E.; Chacón, R. D.

    2009-05-01

    This paper explains the procedure used in the design of a heliostat to be installed at the headquarters of the Centro de Investigaciones de Astronomía, located in the city of Mérida, Venezuela. The heliostat will be used mainly for educational and public outreach programs, so the design specifications did not require compensation for rotation of the Sun's image at the focal point. The engineering computational tools CAD-CAE were used in order to allow a seamless interaction between the two disciplines involved, Mechanical Engineering and Astronomy. It has also been taken into consideration, as a starting requirement, that all materials be easily available and that all parts, excluding the optics, could be manufactured with the equipment available at the CIDA workshop. These considerations were intended to reduce the cost of the device and to increase the feasibility of construction with limited technological facilities and financial resources. The results obtained by means of the computing tools used were validated through comparison against the analytical calculations. As a result, a robust but low cost heliostat was designed which in the near future will be used to project the Sun's image on a screen for public viewing and student research projects.

  18. Tools For Interactive Learning And Self-Management Of Diabetes

    NASA Astrophysics Data System (ADS)

    Capelo, Rita; Baptista, Carla; Figueiredo, Júlia; Carrilho, Francisco; Furtado, Pedro

    2015-05-01

    Diabetes is a widespread disease and its control is dependent upon the patient. Although there is no permanent cure for diabetes, there are several available treatments which, when followed regularly, allow the patient to have a good quality of life. Patient education, especially about eating habits, is key to keep glucose levels stable both in the short and in the long term. This should include nutritional counselling, physical exercise, and the self monitoring of glucose levels. The University of Coimbra and the Serviço de Endocrinologia, Diabetes e Metabolismo of Centro Hospitalar e Universitário de Coimbra started a collaboration to develop interactive tools for the learning and improvement of carbohydrate counting by patients. The approach presented in this paper is an interactive multimedia tool, available to patients through either the web or a smartphone. It helps them to learn how to maintain a healthy diet and how to monitor their insulin levels correctly by measuring the carbo-hidrate “equivalents” in meals. This application will create a more dynamic and interactive way of educating patients, improving solutions currently used in the Serviço de Endocrinologia, Diabetes e Metabolismo of the Centro Hospitalar e Universitário de Coimbra.

  19. Ambiguity Resolution for Phase-Based 3-D Source Localization under Fixed Uniform Circular Array.

    PubMed

    Chen, Xin; Liu, Zhen; Wei, Xizhang

    2017-05-11

    Under fixed uniform circular array (UCA), 3-D parameter estimation of a source whose half-wavelength is smaller than the array aperture would suffer from a serious phase ambiguity problem, which also appears in a recently proposed phase-based algorithm. In this paper, by using the centro-symmetry of UCA with an even number of sensors, the source's angles and range can be decoupled and a novel algorithm named subarray grouping and ambiguity searching (SGAS) is addressed to resolve angle ambiguity. In the SGAS algorithm, each subarray formed by two couples of centro-symmetry sensors can obtain a batch of results under different ambiguities, and by searching the nearest value among subarrays, which is always corresponding to correct ambiguity, rough angle estimation with no ambiguity is realized. Then, the unambiguous angles are employed to resolve phase ambiguity in a phase-based 3-D parameter estimation algorithm, and the source's range, as well as more precise angles, can be achieved. Moreover, to improve the practical performance of SGAS, the optimal structure of subarrays and subarray selection criteria are further investigated. Simulation results demonstrate the satisfying performance of the proposed method in 3-D source localization.

  20. Deaths on board ships assisted by the Centro Internazionale Radio Medico in the last 25 years.

    PubMed

    Grappasonni, Iolanda; Petrelli, Fabio; Amenta, Francesco

    2012-07-01

    Data on occupational diseases of seafarers and of causes of death during their career are sparse. The causes of deaths on board ships assisted by Centro Internazionale Radio Medico (CIRM), the Italian Telemedical Maritime Assistance Service (TMAS) were reviewed by examining 29,146 files of patients treated from 1986 to 2010. In the 25 years, 383 deaths occurred (1.31%). Diseases of the circulation were the most frequent, followed by external causes such as accidents and violence, infectious and parasitic diseases, alcohol and drug addiction, respiratory system diseases. Cardiovascular and external causes were the principal causes of deaths among seafarers. This investigation is the first study on the causes of death on board ships obtained from data of a maritime telemedical centre, that has assisted seafarers when they were alive or immediately after their death. The fact that diseases of the circulatory system are the first cause of death of sailing seafarers deserves specific initiatives. They should include campaigns for adequate lifestyles and the availability on ships of medical devices useful for diagnostic purposes, resuscitation as well as for verification of death. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. On the Role of Mentalizing Processes in Aesthetic Appreciation: An ERP Study.

    PubMed

    Beudt, Susan; Jacobsen, Thomas

    2015-01-01

    We used event-related brain potentials to explore the impact of mental perspective taking on processes of aesthetic appreciation of visual art. Participants (non-experts) were first presented with information about the life and attitudes of a fictitious artist. Subsequently, they were cued trial-wise to make an aesthetic judgment regarding an image depicting a piece of abstract art either from their own perspective or from the imagined perspective of the fictitious artist [i.e., theory of mind (ToM) condition]. Positive self-referential judgments were made more quickly and negative self-referential judgments were made more slowly than the corresponding judgments from the imagined perspective. Event-related potential analyses revealed significant differences between the two tasks both within the preparation period (i.e., during the cue-stimulus interval) and within the stimulus presentation period. For the ToM condition we observed a relative centro-parietal negativity during the preparation period (700-330 ms preceding picture onset) and a relative centro-parietal positivity during the stimulus presentation period (700-1100 ms after stimulus onset). These findings suggest that different subprocesses are involved in aesthetic appreciation and judgment of visual abstract art from one's own vs. from another person's perspective.

  2. VizieR Online Data Catalog: PACS photometry of FIR faint stars (Klaas+, 2018)

    NASA Astrophysics Data System (ADS)

    Klaas, U.; Balog, Z.; Nielbock, M.; Mueller, T. G.; Linz, H.; Kiss, Cs.

    2018-01-01

    70, 100 and 160um photometry of FIR faint stars from PACS scan map and chop/nod measurements. For scan maps also the photometry of the combined scan and cross-scan maps (at 160um there are usually two scan and cross-scan maps each as complements to the 70 and 100um maps) is given. Note: Not all stars have measured fluxes in all three filters. Scan maps: The main observing mode was the point-source mini-scan-map mode; selected scan map parameters are given in column mparam. An outline of the data processing using the high-pass filter (HPF) method is presented in Balog et al. (2014ExA....37..129B). Processing proceeded from Herschel Science Archive SPG v13.1.0 level 1 products with HIPE version 15 build 165 for 70 and 100um maps and from Herschel Science Archive SPG v14.2.0 level 1 products with HIPE version 15 build 1480 for 160um maps. Fluxes faper were obtained by aperture photometry with aperture radii of 5.6, 6.8 and 10.7 arcsec for the 70, 100 and 160um filter, respectively. Noise per pixel sigpix was determined with the histogram method, described in this paper, for coverage values greater than or equal to 0.5*maximum coverage. The number of map pixels (1.1, 1.4, and 2.1 arcsec pixel size, respectively) inside the photometric aperture is Naper = 81.42, 74.12, and 81.56, respectively. The corresponding correction factors for correlated noise are fcorr = 3.13, 2.76, and 4.12, respectively. The noise for the photometric aperture is calculated as sig_aper=sqrt(Naper)*fcorr*sigpix. Signal-to-noise ratios are determined as S/N=faper/sigaper. Aperture-correction factors to derive the total flux are caper = 1.61, 1.56 and 1.56 for the 70, 100 and 160um filter, respectively. Applied colour-correction factors for a 5000K black-body SED are cc = 1.016, 1.033, and 1.074 for the 70, 100, and 160um filter, respectively. The final stellar flux is derived as fstar=faper*caper/cc. Maximum and minimum FWHM of the star PSF are determined by an elliptical fit of the intensity profile. Chop/nod observations: The chop/nod point-source mode is described in this paper. An outline of the data processing is presented in Nielbock et al. (2013ExA....36..631N). Processing proceeded from Herschel Science Archive SPG v11.1.0 level 1 products with HIPE version 13 build 2768. Gyro correction was applied for most of the cases to improve the pointing reconstruction performance. Fluxes faper were obtained by aperture photometry with aperture radii of 5.6, 6.8 and 10.7 arcsec for the 70, 100 and 160um filter, respectively. Noise per pixel sigpix was determined with the histogram method, described in this paper, for coverage values greater than or equal to 0.5*maximum coverage. The number of map pixels (1.1, 1.4, and 2.1 arcsec pixel size, respectively) inside the photometric aperture is Naper = 81.42, 74.12, and 81.56, respectively. The corresponding correction factors for correlated noise are fcorr = 6.33, 4.22, and 7.81, respectively. The noise for the photometric aperture is calculated as sigaper=sqrt(Naper)*fcorr*sigpix. Signal-to-noise ratios are determined as S/N=faper/sigaper. Aperture-correction factors to derive the total flux are caper = 1.61, 1.56 and 1.56 for the 70, 100 and 160um filter, respectively. Applied colour-correction factors for a 5000K black-body SED are cc = 1.016, 1.033, and 1.074 for the 70, 100, and 160um filter, respectively. Maximum and minimum FWHM of the star PSF are determined by an elliptical fit of the intensity profile. (7 data files).

  3. Representing metabolic pathway information: an object-oriented approach.

    PubMed

    Ellis, L B; Speedie, S M; McLeish, R

    1998-01-01

    The University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD) is a website providing information and dynamic links for microbial metabolic pathways, enzyme reactions, and their substrates and products. The Compound, Organism, Reaction and Enzyme (CORE) object-oriented database management system was developed to contain and serve this information. CORE was developed using Java, an object-oriented programming language, and PSE persistent object classes from Object Design, Inc. CORE dynamically generates descriptive web pages for reactions, compounds and enzymes, and reconstructs ad hoc pathway maps starting from any UM-BBD reaction. CORE code is available from the authors upon request. CORE is accessible through the UM-BBD at: http://www. labmed.umn.edu/umbbd/index.html.

  4. VizieR Online Data Catalog: Herschel FIR observations of NGC3603 (Di Cecco+, 2015)

    NASA Astrophysics Data System (ADS)

    di Cecco, A.; Faustini, F.; Paresce, F.; Correnti, M.; Calzoletti, L.

    2015-06-01

    The cloud complex surrounding NGC 3603 YC was observed by Herschel SPIRE/PACS during the Hi-GAL Survey (Molinari et al. 2010A&A...518L.100M, 2010PASP..122..314M), a Key Programme that mapped the Galactic plane in five photometric bands (70, 160, 250, 350, and 500um). The MSX (Egan et al. 2003AAS...203.5708E) images were taken at (wavelengths) 8.3, 12.1, 14.7, and 21.3um using the scan observing mode, and the WISE (Wright et al. 2010AJ....140.1868W) images were acquired in freeze-frame scan mode at 3.4, 4.6, 12, and 22um. (2 data files).

  5. Camões e a cosmogonia

    NASA Astrophysics Data System (ADS)

    Costa, J. M.

    2003-08-01

    Os Lusíadas, escrito por Luis de Camões em 1572, é um poema épico renascentista e a visão Cosmogônica do autor é apresentada, principalmente, no último canto do poema, quando Tétis mostra ao Gama a Máquina do Mundo. A Cosmogonia de Camões neste poema reflete uma visão de uma época de transição, que ainda não incorporou os elementos da revolução Copernicana. É uma visão Grego- Ptolomaica e também medieval. O poeta guia-se pela tradução e notas feita por Pedro Nunes, inventor do Nonio, do Tratado da Esfera "De Sphaera" do Astrônomo Inglês John Holywood, mais conhecido pelo nome latinizado de Johannes Sacrobosco. Outra provável fonte de Camões, de acordo com Luciano Antonio Pereira da Silva em Astronomia de os Lusíadas, é o "Theoricae novae Planetarum" (1460) do astrólogo Alemão Jorge Purbáquio (1423 - 1461). A Astronomia de Os Lusíadas representa a ciência do tempo de Camões. Camões nunca emprega a palavra constelação e seu catálogo é bastante completo. A Máquina do Mundo tem a Terra no centro. Em redor, em círculos concêntricos, a lua (Diana), Mercúrio, Vênus, o Sol (Febo), Marte, Júpiter e Saturno. Envolvendo estes astros tem o firmamento seguido pelo "Céu Áqueo" ou cristalino, depois o 1o Móbil, esfera que arrasta todas as outras consigo. Este trabalho, multidisciplinar, serve tanto para ensinar aos alunos da Física como das Ciências Humanas, a concepção de mundo do renascimento de uma forma belamente poética em versos decassílabos Este trabalho também ajuda na apreciação do maior clássico da língua portuguesa e mostra como as Ciências e as artes, em geral, estão correlacionadas e refletem a visão de mundo da época em que foi produzida.

  6. Critical incidents connected to nurses' leadership in Intensive Care Units.

    PubMed

    Lima, Elaine Cantarella; Bernardes, Andrea; Baldo, Priscila Lapaz; Maziero, Vanessa Gomes; Camelo, Silvia Helena Henriques; Balsanelli, Alexandre Pazetto

    2017-01-01

    The goal of this study is to analyze nurses' leadership in intensive care units at hospitals in the state of São Paulo, Brazil, in the face of positive and negative critical incidents. Exploratory, descriptive study, conducted with 24 nurses by using the Critical Incident Technique as a methodological benchmark. Results were grouped into 61 critical incidents distributed into categories. Researchers came to the conclusion that leadership-related situations interfere with IC nurses' behaviors. Among these situations they found: difficulty in the communication process; conflicts in the daily exercise of nurses' activities; people management; and the setting of high quality care targets. Researchers identified a mixed leadership model, leading them to the conclusion that nurses' knowledge and practice of contemporary leadership theories/styles are crucial because they facilitate the communication process, focusing on behavioral aspects and beliefs, in addition to valuing flexibility. This positively impacts the organization's results. Analisar a liderança do enfermeiro em Centros de Terapia Intensiva de hospitais localizados no interior do estado de São Paulo, diante de incidentes críticos positivos e negativos. Estudo exploratório, descritivo, realizado com 24 enfermeiros, que utilizou a Técnica do Incidente Crítico como referencial metodológico. Os resultados foram agrupados em 61 incidentes críticos distribuídos em categorias. Identificou-se que situações relacionadas à liderança interferem no comportamento do enfermeiro de Terapia Intensiva, dentre elas: dificuldade no processo de comunicação, conflitos existentes no dia a dia do exercício profissional, gerenciamento de pessoas e estabelecimento de metas para o alcance da assistência qualificada. Encontrou-se um modelo misto de liderança, o que permite concluir que o conhecimento e a prática dos enfermeiros acerca de teorias/estilos contemporâneos de liderança tornam-se fundamentais, pois facilitam o processo de comunicação, focando nos aspectos comportamentais e crenças, e valorizam a flexibilidade, impactando positivamente os resultados da organização.

  7. Building sustainability indicators in the health dimension for solid waste management.

    PubMed

    Veiga, Tatiane Bonametti; Coutinho, Silvano da Silva; Andre, Silvia Carla Silva; Mendes, Adriana Aparecida; Takayanagui, Angela Maria Magosso

    2016-08-08

    to prepare a list of sustainability indicators in the health dimension, for urban solid waste management. a descriptive and exploratory study performed jointly with 52 solid waste specialists, using a three-steps Delphi technique, and a scale measuring the degree of importance for agreement among the researchers in this area. the subjects under study were 92,3% PhD's concentrated in the age group from 30 to 40 years old (32,7%) and 51% were men. At the end of the 3rd step of the Delphi process, the average and standard deviation of all the proposed indicators varied from 4,22 (±0,79) to 4,72 (±0,64), in a scale of scores for each indicator from 1 to 5 (from "dispensable" to "very important"). Results showed the level of correspondence among the participants ranging from 82% to 94% related to those indicators. the proposed indicators may be helpful not only for the identification of data that is updated in this area, but also to enlarge the field of debates of the environmental health policies, directed not only for urban solid waste but for the achievement of better health conditions for the Brazilian context. elaborar uma lista de indicadores de sustentabilidade na dimensão da saúde para gestão de resíduos sólidos urbanos. estudo descritivo e exploratório, realizado com 52 especialistas na área de resíduos sólidos, utilizando a técnica Delphi em três etapas, com o uso da escala de mensuração do grau de importância para obtenção de consenso entre pesquisadores da área da investigação. dos sujeitos estudados , 92,3% eram doutores, com maior concentração na faixa etária entre 30 e 40 anos (32,7%) e 51,0% do sexo masculino. Ao final da 3ª etapa de aplicação da técnica Delphi, a média e o desvio-padrão de todos os indicadores propostos variaram de 4,22 (±0,79) a 4,72 (±0,64), em uma escala de pontuação atribuída para cada indicador de 1 a 5 (Respectivamente, de "dispensável" a "muito importante"). Os resultados demonstraram nível de concordância entre os sujeitos participantes que variou de 82% a 94% em relação a esses indicadores. os indicadores propostos podem auxiliar, tanto na identificação de dados atualizados no setor, quanto na ampliação das discussões das políticas de saúde ambiental, voltadas não apenas para resíduos sólidos urbanos, mas objetivando também o alcance de melhores condições de saúde no contexto da atual realidade brasileira. elaborar una lista de indicadores de sostenibilidad en la dimensión salud para la gestión de residuos sólidos urbanos. estudio descriptivo y exploratorio realizado con 52 especialistas en el área de residuos sólidos, utilizando la técnica Delphi en tres etapas, con uso de escala de medida de grado de importancia para obtención de consenso entre investigadores de esta área. de los sujetos estudiados , 92,3% tenían doctorado con mayor concentración en el grupo etario entre 30 y 40 años (32,7%) y 51% del sexo masculino. Al final de la 3ª. Etapa de aplicación de la técnica Delphi, el promedio y el desvío estándar de todos los indicadores propuestos variaron de 4,22 (±0,79) a 4,72 (±0,64), en una escala de puntos atribuida a cada indicador de 1 a 5 (Respectivamente de "dispensable" a "muy importante"). Los resultados mostraron un nivel de acuerdo entre los sujetos participantes que varió de 82% a 94% en relación a estos indicadores. los indicadores propuestos pueden ayudar tanto en la identificación de datos actualizados en este sector, como también para ampliar las discusiones de las políticas de salud ambiental, dirigidas no solamente para residuos sólidos urbanos pero también para alcanzar mejores condiciones de salud en el contexto de la realidad brasileña actual.

  8. DEVELOPMENT OF A SAMPLING PROCEDURE FOR LARGE NITROGEN- AND SULFUR-BEARING AEROSOLS

    EPA Science Inventory

    A single-stage impactor was modified to utilize a removable TFE impaction surface mounted on the end of an annular denuder. hen used with a polycarbonate filter coated with silicone oil, its cut point was 2.5 um and bounce was <1% for 8-um particles. ignificant bounce occurred wi...

  9. First Results from the ISO-IRAS Faint Galaxy Survey

    NASA Technical Reports Server (NTRS)

    Wolstencroft, R. D.; Wehrle, A. E.; Levine, D. A.

    1997-01-01

    We present the first result from the ISO-IRAS Faint Galaxy Survey (IIFGS), a program designed to obtain ISO observations of the most distant and luminous galaxies in the IRAS Faint Source Survey by filling short gaps in the ISO observing schedule with pairs of 12um ISOCAM AND 90um ISOPHOT observation.

  10. Students' Perceptions of Blackboard and Moodle in a Portuguese University

    ERIC Educational Resources Information Center

    Carvalho, Ana; Areal, Nelson; Silva, Joaquim

    2011-01-01

    The use of learning management systems (LMS) has grown considerably in universities around the world. The University of Minho (UM) has pioneered in this area in Portugal, adopting Blackboard as its official LMS. Moodle is also used in UM in scattered initiatives, allowing for interesting comparisons. Previous studies comparing Blackboard and…

  11. Use of "um" in the Deceptive Speech of a Convicted Murderer

    ERIC Educational Resources Information Center

    Villar, Gina; Arciuli, Joanne; Mallard, David

    2012-01-01

    Previous studies have demonstrated a link between language behaviors and deception; however, questions remain about the role of specific linguistic cues, especially in real-life high-stakes lies. This study investigated use of the so-called filler, "um," in externally verifiable truthful versus deceptive speech of a convicted murderer. The data…

  12. Closing the Math Achievement Gap: Institutions Find Success with MyMathLab

    ERIC Educational Resources Information Center

    Stewart, Pearl

    2012-01-01

    Institutions find success with Pearson Education's MyMathLab. The Department of Mathematical Sciences at the University of Memphis (UM) reported a narrowing of the achievement gap between Black and White students. According to the study conducted by UM professors and titled "The Effectiveness of Blended Instruction in Postsecondary General…

  13. DETERMINING COARSE PARTICULATE MATTER CONCENTRATIONS: A PERFORMANCE EVALUATION OF CANDIDATE METHODOLOGIES UNDER WINTERTIME CONDITIONS

    EPA Science Inventory

    The main objective of this study is to evaluate the performance of sampling methods for potential use as a Federal Reference Method (FRM) capable of providing an estimate of coarse particle (PMc: particulate matter with an aerodynamic diameter between 2.5 um and 10 um) mass con...

  14. TRIBUTYLTIN AND DEXAMETHASONE INDUCE APOPTOSIS IN RAT THYMOCYTES BY MUTUALLY ANTAGONISTIC MECHANISMS

    EPA Science Inventory

    We observed that rat thymocyte cultures exposed to 1.O'- 2. 5 uM tri-n-butyltin methoxide (TBT) exhibiteda rapid time- and concentration-dependent induction of apoptosis, with > 85% of cells exhibiting reduced DNAcontent within 1 hr after ensure to 2.0 - 2,5 uM TBT. Moreover, wit...

  15. Nonlinear THz Plamonic Disk Resonators

    NASA Astrophysics Data System (ADS)

    Seren, Huseyin; Zhang, Jingdi; Keiser, George; Maddox, Scott; Fan, Kebin; Cao, Lingyue; Bank, Seth; Zhang, Xin; Averitt, Richard

    2013-03-01

    Particle surface plasmons (PPSs) at visible wavelengths continue to be actively investigated with the goal of nanoscale control of light. In contrast, terahertz (THz) surface plasmon experiments are at a nascent stage of investigation. Doped semiconductors with proper carrier density and mobility support THz PSPs. One approach is to utilize thick doped films etched into subwavelength disks. Given the ease of tuning the semiconductor carrier density, THz PSPs are tunable and exhibit interesting nonlinear THz plasmonic effects. We created THz PSP structures using MBE grown 2um thick InAs films with a doping concentration of 1e17cm-3 on 500um thick semi-insulating GaAs substrate. We patterned 40um diameter disks with a 60um period by reactive ion etching. Our THz time-domain measurements reveal a resonance at 1.1THz which agrees well with simulation results using a Drude model. A nonlinear response occurs at high THz electric field strengths (>50kV/cm). In particular, we observed a redshift and quenching of the resonance due to impact ionization which resulted in changes in the carrier density and effective mass due to inter-valley scattering.

  16. Cartilage ablation studies using mid-IR free electron laser

    NASA Astrophysics Data System (ADS)

    Youn, Jong-In; Peavy, George M.; Venugopalan, Vasan

    2005-04-01

    The ablation rate of articular cartilage and fibrocartilage (meniscus), were quantified to examine wavelength and tissue-composition dependence of ablation efficiency for selected mid-infrared wavelengths. The wavelengths tested were 2.9 um (water dominant absorption), 6.1 (protein and water absorption) and 6.45 um (protein dominant absorption) generated by the Free Electron Laser (FEL) at Vanderbilt University. The measurement of tissue mass removal using a microbalance during laser ablation was conducted to determine the ablation rates of cartilage. The technique can be accurate over methods such as profilometer and histology sectioning where tissue surface and the crater morphology may be affected by tissue processing. The ablation efficiency was found to be dependent upon the wavelength. Both articular cartilage and meniscus (fibrocartilage) ablations at 6.1 um were more efficient than those at the other wavelengths evaluated. We observed the lowest ablation efficiency of both types of cartilage with the 6.45 um wavelength, possibly due to the reduction in water absorption at this wavelength in comparison to the other wavelengths that were evaluated.

  17. VizieR Online Data Catalog: Spitzer observations of Taurus members (Luhman+, 2010)

    NASA Astrophysics Data System (ADS)

    Luhman, K. L.; Allen, P. R.; Espaillat, C.; Hartmann, L.; Calvet, N.

    2016-03-01

    For our census of the disk population in Taurus, we use images at 3.6, 4.5, 5.8, and 8.0um obtained with Spitzer's Infrared Array Camera (IRAC) and images at 24um obtained with the Multiband Imaging Photometer for Spitzer (MIPS). The cameras produced images with FWHM=1.6"-1.9" from 3.6 to 8.0um and FWHM=5.9" at 24um. The available data were obtained through Guaranteed Time Observations for PID = 6, 36, 37 (G. Fazio), 53 (G. Rieke), 94 (C. Lawrence), 30540 (G. Fazio, J. Houck), and 40302 (J. Houck), Director's Discretionary Time for PID = 462 (L. Rebull), Legacy programs for PID = 139, 173 (N. Evans), and 30816 (D. Padgett), and General Observer programs for PID = 3584 (D. Padgett), 20302 (P. Andre), 20386 (P. Myers), 20762 (J. Swift), 30384 (T. Bourke), 40844 (C. McCabe), and 50584 (D. Padgett). The IRAC and MIPS observations were performed through 180 and 137 Astronomical Observation Requests (AORs), respectively. The characteristics of the resulting images are summarized in Tables 1 and 2. (6 data files).

  18. Cascaded Ga1-xAlxAs/GaAs solar cell with graded i-region

    NASA Astrophysics Data System (ADS)

    Mil'shtein, Sam; Halilov, Samed

    2018-02-01

    In current study we designed p-i-n junction with extended intrinsic layer, where linearly graded Alx Ga1-x As presents variable energy gap so needed for effective harvesting of sun radiation. The design realization involves two regions of compositional structure in the stacking direction. The top AlxGa1-xAs layer of 1 um total thickness has stoichiometric structure x=0.3-0.2d, where depth d runs from 0 to 1 um, topmost 200 nm of which is Be-doped. Bottom AlxGa1-xAs layer of 3 um total thickness has a variable composition of x=0.133-0.033d, d runs from 1 to 4 um, the very bottom of which with 10 nm thickness is Si-doped. On the top surface, there is a 50 nm layer of p+ doped GaAs as a spacer for growing AuGe/Ni anode electrode of 20% surface area, the bottom is coated with AuGe/Ni cathode electrode. The designed cell demonstrates 89% fill factor and 30% conversion efficiency without anti-reflection coating.

  19. Removal of sudan dyes from water with C18-functional ultrafine magnetic silica nanoparticles.

    PubMed

    Jiang, Chunzhu; Sun, Ying; Yu, Xi; Zhang, Lei; Sun, Xiumin; Gao, Yan; Zhang, Hanqi; Song, Daqian

    2012-01-30

    In this study, the new C(18)-functionalized ultrafine magnetic silica nanoparticles (C(18)-UMS NPs) were successfully synthesized and applied for extraction of sudan dyes in water samples based on the magnetic solid-phase extraction (MSPE). The extraction and concentration were carried out in one step by blending C(18)-UMS NPs and water samples. The sudan dyes adsorbed C(18)-UMS NPs were isolated from the matrix easily with an external magnetic field. After desorption the quantitation of sudan dyes was done by ultra fast liquid chromatography (UFLC). Satisfactory extraction recovery can be obtained with only 50 mg C(18)-UMS NPs. The effects of experimental parameters, including the amount of the nanoparticles, extraction time, pH value, desorption solvent, volume of desorption solvent and desorption time were investigated. The limits of detection for sudan I, II, III and IV were 0.066, 0.070, 0.12 and 0.12 ng mL(-1), respectively. Recoveries obtained by analyzing the six spiked water samples were between 68% and 103%. Copyright © 2011 Elsevier B.V. All rights reserved.

  20. Optimization of microphysics in the Unified Model, using the Micro-genetic algorithm.

    NASA Astrophysics Data System (ADS)

    Jang, J.; Lee, Y.; Lee, H.; Lee, J.; Joo, S.

    2016-12-01

    This study focuses on parameter optimization of microphysics in the Unified Model (UM) using the Micro-genetic algorithm (Micro-GA). We need the optimization of microphysics in UM. Because, Microphysics in the Numerical Weather Prediction (NWP) model is important to Quantitative Precipitation Forecasting (QPF). The Micro-GA searches for optimal parameters on the basis of fitness function. The five parameters are chosen. The target parameters include x1, x2 related to raindrop size distribution, Cloud-rain correlation coefficient, Surface droplet number and Droplet taper height. The fitness function is based on the skill score that is BIAS and Critical Successive Index (CSI). An interface between UM and Micro-GA is developed and applied to three precipitation cases in Korea. The cases are (ⅰ) heavy rainfall in the Southern area because of typhoon NAKRI, (ⅱ) heavy rainfall in the Youngdong area, and (ⅲ) heavy rainfall in the Seoul metropolitan area. When the optimized result is compared to the control result (using the UM default value, CNTL), the optimized result leads to improvements in precipitation forecast, especially for heavy rainfall of the late forecast time. Also, we analyze the skill score of precipitation forecasts in terms of various thresholds of CNTL, Optimized result, and experiments on each optimized parameter for five parameters. Generally, the improvement is maximized when the five optimized parameters are used simultaneously. Therefore, this study demonstrates the ability to improve Korean precipitation forecasts by optimizing microphysics in UM.

  1. Using a home blood pressure monitor: do accompanying instructional materials meet low literacy guidelines?

    PubMed

    Wallace, Lorraine S; Keenum, Amy J

    2008-08-01

    To evaluate the readability and related features of English language Quick Reference Guides (QRGs) and User Manuals (UMs) accompanying home blood pressure monitors (HBPMs). We evaluated QRGs and UMs for 22 HBPMs [arm (n=12); wrist (n=10)]. Using established criteria, we evaluated reading grade level, language availability, dimensions, text point size, use of illustrations, layout/formatting characteristics, and emphasis of key points of English-language patient instructions accompanying HBPMs. Readability was calculated using McLaughlin's Simplified Measure of Gobbledygoop. Items from the Suitability of Materials Assessment and User-Friendliness Tool were used to assess various layout features. Simplified Measure of Gobbledygoop scores of both QRGs (mean+/-SD=9.1+/-0.8) and UMs (9.3+/-0.8) ranged from 8th to 10th grade. QRGs and UMs presented steps in chronological order, used active voice throughout, avoided use of specialty fonts, focused on need to know, and used realistic illustrations. Seven sets of instructions included all seven key points related to proper HPBM use, whereas three sets of instructions included less than or equal to three key points (mean=4.8+/-1.9). Although most QRGs and UMs met at least some recommended low-literacy formatting guidelines, all instructional materials should be developed and tested to meet the needs of the patient population at large. Key points related to proper HBPM use should not only be included within these instructions, but highlighted to emphasize their importance.

  2. Jupiter-Io Montage

    NASA Technical Reports Server (NTRS)

    2007-01-01

    This is a montage of New Horizons images of Jupiter and its volcanic moon Io, taken during the spacecraft's Jupiter flyby in early 2007. The Jupiter image is an infrared color composite taken by the spacecraft's near-infrared imaging spectrometer, the Linear Etalon Imaging Spectral Array (LEISA) at 1:40 UT on Feb. 28, 2007. The infrared wavelengths used (red: 1.59 um, green: 1.94 um, blue: 1.85 um) highlight variations in the altitude of the Jovian cloud tops, with blue denoting high-altitude clouds and hazes, and red indicating deeper clouds. The prominent bluish-white oval is the Great Red Spot. The observation was made at a solar phase angle of 75 degrees but has been projected onto a crescent to remove distortion caused by Jupiter's rotation during the scan. The Io image, taken at 00:25 UT on March 1st 2007, is an approximately true-color composite taken by the panchromatic Long-Range Reconnaissance Imager (LORRI), with color information provided by the 0.5 um ('blue') and 0.9 um ('methane') channels of the Multispectral Visible Imaging Camera (MVIC). The image shows a major eruption in progress on Io's night side, at the northern volcano Tvashtar. Incandescent lava glows red beneath a 330-kilometer high volcanic plume, whose uppermost portions are illuminated by sunlight. The plume appears blue due to scattering of light by small particles in the plume

    This montage appears on the cover of the Oct. 12, 2007, issue of Science magazine.

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenfeld, Daniel; Wang, Hailong; Rasch, Philip J.

    Numerical simulations described in previous studies showed that adding cloud condensation nuclei to marine stratocumulus can prevent their breakup from closed into open cells. Additional analyses of the same simulations show that the suppression of rain is well described in terms of cloud drop effective radius (re). Rain is initiated when re near cloud top is around 12-14 um. Cloud water starts to get depleted when column-maximum rain intensity (Rmax) exceeds 0.1 mm h-1. This happens when cloud-top re reaches 14 um. Rmax is mostly less than 0.1 mm h-1 at re<14 um, regardless of the cloud water path, butmore » increases rapidly when re exceeds 14 um. This is in agreement with recent aircraft observations and theoretical observations in convective clouds so that the mechanism is not limited to describing marine stratocumulus. These results support the hypothesis that the onset of significant precipitation is determined by the number of nucleated cloud drops and the height (H) above cloud base within the cloud that is required for cloud drops to reach re of 14 um. In turn, this can explain the conditions for initiation of significant drizzle and opening of closed cells providing the basis for a simple parameterization for GCMs that unifies the representation of both precipitating and non-precipitating clouds as well as the transition between them. Furthermore, satellite global observations of cloud depth (from base to top), and cloud top re can be used to derive and validate this parameterization.« less

  4. Comparative study between kidney transplantation with deceased donor expanded criteria and donor standard criteria in a single center in Brazil.

    PubMed

    Mota, Luana Soriano; Oliveira, Claudia Maria Costa de; Pinheiro, Francisco Martho Leal; Santos, Larissa Costa de Oliveira; Nóbrega, Danilo Gonçalves; Fernandes, Paula Fbc; Costa, Alda Angélica de Melo; Silva, Sônia Leite da

    2016-01-01

    Kidney transplants with expanded criteria donor have been associated with improved patient survival compared to those who remain on dialysis. To compare renal function and survival of the kidney graft of deceased donor with expanded criteria and standard criteria over a year in a single transplant center. 255 kidney transplant recipients with deceased donor were included in the study between the years 2011 to 2013 and they were separated into two groups according to the type of donor (expanded criteria donor - ECD - and standard criteria donor - SCD). 231 deceased donor transplants (90.6%) were performed with standard criteria donor (SCD) and 24 (9.4%) with expanded criteria donor (ECD). There was no difference in the prevalence of delayed graft function - DGF - (62.9% vs. 70.8%; p = 0.44). Expanded criteria donor group had lower glomerular filtration rate (GFR) at the end of the 1st year (56.8 ± 26.9 vs. 76.9 ± 23.7; p = 0.001). Patient survival was significantly lower in the ECD group, but the graft survival was not different after death-censored analysis. The ECD group was associated with significantly lower levels of GFR during the first year of transplant and a lower patient survival at the 1st year when compared to the SCD. A aceitação dos rins com critério expandido de doação tem sido associada com melhor sobrevida do paciente em comparação àqueles que permanecem em terapia dialítica. Comparar a função renal e a sobrevida do enxerto renal de doador falecido critério expandido com os de doador falecido critério padrão ao longo de um ano em um único centro de transplantes. Foram incluídos 255 receptores de transplante renal com doador falecido, realizados entre os anos de 2011 a 2013, sendo divididos em dois grupos segundo o tipo de doador (critério expandido - DCE - ou padrão -DCP). Foram avaliados 231 receptores com doador critério ideal (90,6%) e 24 com doador critério expandido (9,4%). Não houve diferença na prevalência de função retardada do enxerto - DGF - (62,9% no DCP vs. 70,8% no DCE; p = 0,44) nos dois grupos. Os transplantes com DCE apresentaram uma taxa de filtração glomerular (TFG) significativamente inferior aos 12 meses (56,8 ± 26,9 vs. 76,9 ± 23,7; p = 0,001). A sobrevida dos pacientes em 1 ano foi significativamente inferior no grupo de DCE, mas não houve diferença na sobrevida dos enxertos após exclusão de perdas por óbito com rim funcionante. O grupo com DCE associou-se com níveis significativamente mais baixos de TFG ao longo do primeiro ano de transplante, bem como uma menor sobrevida dos pacientes em 1 ano, quando comparado ao grupo com doador padrão.

  5. Busca de estruturas em grandes escalas em altos redshifts

    NASA Astrophysics Data System (ADS)

    Boris, N. V.; Sodré, L., Jr.; Cypriano, E.

    2003-08-01

    A busca por estruturas em grandes escalas (aglomerados de galáxias, por exemplo) é um ativo tópico de pesquisas hoje em dia, pois a detecção de um único aglomerado em altos redshifts pode por vínculos fortes sobre os modelos cosmológicos. Neste projeto estamos fazendo uma busca de estruturas distantes em campos contendo pares de quasares próximos entre si em z Â3 0.9. Os pares de quasares foram extraídos do catálogo de Véron-Cetty & Véron (2001) e estão sendo observados com os telescópios: 2,2m da University of Hawaii (UH), 2,5m do Observatório de Las Campanas e com o GEMINI. Apresentamos aqui a análise preliminar de um par de quasares observado nos filtros i'(7800 Å) e z'(9500 Å) com o GEMINI. A cor (i'-z') mostrou-se útil para detectar objetos "early-type" em redshifts menores que 1.1. No estudo do par 131046+0006/J131055+0008, com redshift ~ 0.9, o uso deste método possibilitou a detecção de sete objetos candidatos a galáxias "early-type". Num mapa da distribuição projetada dos objetos para 22 < i' < 25 observou-se que estas galáxias estão localizadas próximas a um dos quasares e há indícios de que estejam aglomeradas dentro de um área de ~ 6 arcmin2. Se esse for o caso, estes objetos seriam membros de uma estrutura em grande escala. Um outro argumento em favor dessa hipótese é que eles obedecem uma relação do tipo Kormendy (raio equivalente X brilho superficial dentro desse raio), como a apresentada pelas galáxias elípticas em z = 0.

  6. Variation in aluminum, iron, and particle concentrations in oxic groundwater samples collected by use of tangential-flow ultrafiltration with low-flow sampling

    NASA Astrophysics Data System (ADS)

    Szabo, Zoltan; Oden, Jeannette H.; Gibs, Jacob; Rice, Donald E.; Ding, Yuan

    2002-02-01

    Particulates that move with ground water and those that are artificially mobilized during well purging could be incorporated into water samples during collection and could cause trace-element concentrations to vary in unfiltered samples, and possibly in filtered samples (typically 0.45-um (micron) pore size) as well, depending on the particle-size fractions present. Therefore, measured concentrations may not be representative of those in the aquifer. Ground water may contain particles of various sizes and shapes that are broadly classified as colloids, which do not settle from water, and particulates, which do. In order to investigate variations in trace-element concentrations in ground-water samples as a function of particle concentrations and particle-size fractions, the U.S. Geological Survey, in cooperation with the U.S. Air Force, collected samples from five wells completed in the unconfined, oxic Kirkwood-Cohansey aquifer system of the New Jersey Coastal Plain. Samples were collected by purging with a portable pump at low flow (0.2-0.5 liters per minute and minimal drawdown, ideally less than 0.5 foot). Unfiltered samples were collected in the following sequence: (1) within the first few minutes of pumping, (2) after initial turbidity declined and about one to two casing volumes of water had been purged, and (3) after turbidity values had stabilized at less than 1 to 5 Nephelometric Turbidity Units. Filtered samples were split concurrently through (1) a 0.45-um pore size capsule filter, (2) a 0.45-um pore size capsule filter and a 0.0029-um pore size tangential-flow filter in sequence, and (3), in selected cases, a 0.45-um and a 0.05-um pore size capsule filter in sequence. Filtered samples were collected concurrently with the unfiltered sample that was collected when turbidity values stabilized. Quality-assurance samples consisted of sequential duplicates (about 25 percent) and equipment blanks. Concentrations of particles were determined by light scattering.

  7. Impact of Tile Drainage on the Distribution of Concentration and Age of Inorganic Soil Nitrogen.

    NASA Astrophysics Data System (ADS)

    Woo, D.; Kumar, P.

    2017-12-01

    Extensive network of tile drainage network across the Midwestern United States, northern Europe and other regions of the world have enhanced agricultural productivity. Because of its impact on sub-surface flow patterns and moisture and temperature dynamics, it controls the nitrogen cycle in agricultural systems, and its influence on nitrogen dynamics plays a key role in determining the short- and long-term evolution of soil inorganic nitrogen concentration and age. The spatial mapping of nitrogen concentration and age under tile-drained fields has, therefore, the potential to open up novel solution to the vexing challenge of reducing environmental impacts while at the same time maintaining agricultural productivity. The objective of this study is to explore the impacts of tile drains on the age dynamics of nitrate, immobile ammonium, mobile ammonia/um, and non-reactive tracer (such as chloride) by implementing two mobile interacting pore domains to capture matrix and preferential flow paths in a coupled ecohydrology and biogeochemistry model, Dhara. We applied this model to an agricultural farm supporting a corn-soybean rotation in the Midwestern United States. It should be expected that the installation of tile drains decrease the age of soil nutrient due to nutrient losses through tile drainage. However, an increase in the age of mobile ammonia/um is observed in contrast to the cases for nitrate, immobile ammonium, and non-reactive tracer. These results arise because the depletion of mobile ammonia/um due to tile drainage causes a high mobility flux from immobile ammonium to mobile ammonia/um, which also carries a considerable amount of relatively old age of immobile ammonium to mobile ammonia/um. In addition, the ages of nitrate and mobile ammonia/um in tile drainage range from 1 to 3 years, and less than a year, respectively, implying that not considering age transformations between nitrogen species would result in substantial underestimation of nitrogen ages, possibly leading to an erroneous conclusion.

  8. Evaluation of Laser Stabilization and Imaging Systems for LCLS-II - Final Paper

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barry, Matthew

    2015-08-20

    By combining the top performing commercial laser beam stabilization system with the most ideal optical imaging configuration, the beamline for the Linear Accelerator Coherent Light Source II (LCLS-II) will deliver the highest quality and most stable beam to the cathode. To determine the optimal combination, LCLS-II beamline conditions were replicated and the systems tested with a He-Ne laser. The Guidestar-II and MRC active laser beam stabilization systems were evaluated for their ideal positioning and stability. Both a two and four lens optical imaging configuration was then evaluated for beam imaging quality, magnification properties, and natural stability. In their best performancesmore » when tested over fifteen hours, Guidestar-II kept the beam stable over approximately 70-110um while the MRC system kept it stable over approximately 90-100um. During short periods of time, Guidestar-II kept the beam stable between 10-20um, but was more susceptible to drift over time, while the MRC system maintained the beam between 30-50um with less overall drift. The best optical imaging configuration proved to be a four lens system that images to the iris located in the cathode room and from there, imaged to the cathode. The magnification from the iris to the cathode was 2:1, within an acceptable tolerance to the expected 2.1:1 magnification. The two lens configuration was slightly more stable in small periods of time (less than 10 minutes) without the assistance of a stability system, approximately 55um compared to approximately 70um, but the four lens configurations beam image had a significantly flatter intensity distribution compared to the two lens configuration which had a Gaussian distribution. A final test still needs to be run with both stability systems running at the same time through the four lens system. With this data, the optimal laser beam stabilization system can be determined for the beamline of LCLS-II.« less

  9. Ultrasonic location system =

    NASA Astrophysics Data System (ADS)

    Albuquerque, Daniel Filipe

    Esta tese apresenta um sistema de localizacao baseado exclusivamente em ultrassons, nao necessitando de recorrer a qualquer outra tecnologia. Este sistema de localizacao foi concebido para poder operar em ambientes onde qualquer outra tecnologia nao pode ser utilizada ou o seu uso esta condicionado, como sao exemplo aplicacoes subaquaticas ou ambientes hospitalares. O sistema de localizacao proposto faz uso de uma rede de farois fixos permitindo que estacoes moveis se localizem. Devido a necessidade de transmissao de dados e medicao de distancias foi desenvolvido um pulso de ultrassons robusto a ecos que permite realizar ambas as tarefas com sucesso. O sistema de localizacao permite que as estacoes moveis se localizem escutando apenas a informacao em pulsos de ultrassons enviados pelos farois usando para tal um algoritmo baseado em diferencas de tempo de chegada. Desta forma a privacidade dos utilizadores e garantida e o sistema torna-se completamente independente do numero de utilizadores. Por forma a facilitar a implementacao da rede de farois apenas sera necessario determinar manualmente a posicao de alguns dos farois, designados por farois ancora. Estes irao permitir que os restantes farois, completamente autonomos, se possam localizar atraves de um algoritmo iterativo de localizacao baseado na minimizacao de uma funcao de custo. Para que este sistema possa funcionar como previsto sera necessario que os farois possam sincronizar os seus relogios e medir a distancia entre eles. Para tal, esta tese propoe um protocolo de sincronizacao de relogio que permite tambem obter as medidas de distancia entre os farois trocando somente tres mensagens de ultrassons. Adicionalmente, o sistema de localizacao permite que farois danificados possam ser substituidos sem comprometer a operabilidade da rede reduzindo a complexidade na manutencao. Para alem do mencionado, foi igualmente implementado um simulador de ultrassons para ambientes fechados, o qual provou ser bastante preciso e uma ferramenta de elevado valor para simular o comportamento do sistema de localizacao sobre condicoes controladas.

  10. Desenvolvimento das câmeras de raios-X duros do satélite MIRAX

    NASA Astrophysics Data System (ADS)

    Braga, J.; Rothschild, R.; Staubert, R.; Heise, J.; Remillard, R.; D'Amico, F.; Jablonski, F.; Mejía, J.; Carvalho, H.; Heindl, B.; Matteson, J.; Kendziorra, E.; Wilms, J.; in't Zand, J.; Kuulkers, E.

    2003-08-01

    O MIRAX (Monitor e Imageador de RAios-X) é um projeto de desenvolvimento de um pequeno satélite astronômico de raios-X (~200 kg, ~240 W). A estratégia básica da missão será observar continuamente (~9 meses por ano) a região central (~1000 graus2) do plano Galáctico e realizar estudos espectroscópicos de banda larga (2-200 keV) e alta sensibilidade de um grande conjunto de fontes através de imagens com resolução de ~6'. Isso proporcionará uma cobertura inédita do "espaço de descobertas" através da detecção, localização, identificação e estudo detalhado de fenômenos imprevisíveis, tais como transientes fracos de raios-X, novas rápidas de raios-X e bursts de raios gama, assim como o estudo de fontes com emissão persistente. Neste trabalho apresentamos o projeto das duas câmeras de raios-X duros (CXDs) do MIRAX, que irão operar na faixa de 10 a 200 keV. Cada CXD consistirá de um plano de detectores CZT (Cd0,9Zn0,1Te) de 0,5 mm de resolução espacial e 370 cm2 de área total, e de uma máscara codificada com elementos quadrados de 1,3 mm de lado e 0,5 cm de espessura. A máscara terá dimensões de 315 cm ´ 275 cm e será montada a 700 cm de distância dos detectores. Com essa configuração as CXDs terão 6' de resolução angular e, quando colocadas a um ângulo de 29° entre si, as duas câmeras propiciam um campo totalmente codificado de 39° ´ 6°12' e um campo total de 76° ´ 44°. Serão apresentadas simulações de observações da região do plano Galáctico com o conjunto formado pelas duas CXDs.

  11. Transient deep-water oxygenation in the early Cambrian Nanhua Basin, South China

    NASA Astrophysics Data System (ADS)

    Cheng, Meng; Li, Chao; Zhou, Lian; Feng, LianJun; Algeo, Thomas J.; Zhang, FeiFei; Romaniello, Stephen; Jin, ChengSheng; Ling, HongFei; Jiang, ShaoYong

    2017-08-01

    Many late Neoproterozoic to early Cambrian fossils of multicellular eukaryotes, including those of benthic animals, are found preserved under anoxic and even euxinic bottom-water conditions, which is contradictory to the consensus that oxygen is essential to eukaryotes. To investigate this conundrum, we conducted an integrated study of iron speciation, redox-sensitive trace elements, and Mo isotopes (δ98Mo) on the black shale interval of the lower Cambrian Hetang Formation (∼535-521 Ma) at Lantian, South China, in which benthic sponge fossils are abundant in the lower member (LM) but absent in the upper member (UM). Iron speciation data point to uniformly anoxic-ferruginous conditions in the LM and euxinic conditions in the UM, whereas the trace-element and δ98Mo data show greater secular variation in redox conditions. The LM shows higher mean trace element concentrations (Mo: 108 ppm, U: 36 ppm, V: 791 ppm) and lower and more variable δ98Mo (+0.13 to +1.76‰) relative to the UM (Mo: 45 ppm, U: 18 ppm, V: 265 ppm, δ98Mo: +1.59 to +1.67‰), and ratios of redox-sensitive trace element concentrations to total organic carbon are significantly more variable and higher on average in the LM relative to the UM. The appearance of sponge fossils and lower δ98Mo values correlate strongly with gray (i.e., lighter-colored) layers in the LM. These patterns can best be interpreted as recording mainly euxinic conditions throughout deposition of the study units, with more intense background euxinia in the LM relative to the UM, but also with frequent transient oxygenation events in the LM that do not appear in the UM. The transient oxygenation events of the LM led to the initial colonization of the deep Nanhua Basin by sponges, and the termination of these events in the UM caused sponge faunas to disappear until a general rise in O2 levels later in the Cambrian permitted their return to deeper-water habitats. Our study also illustrates that multiple geochemical and paleobiological proxies exhibit different responses in 'poikiloredox' environments (i.e., characterized by small-scale spatial and high-frequency temporal variations), which can lead to apparent contradictions between metazoan fossil occurrences and their inferred watermass redox conditions.

  12. A teoria da percolação aplicada às galáxias aneladas peculiares

    NASA Astrophysics Data System (ADS)

    Poppe, P. C. R.; Martin, V. A. F.; de Medeiros, N. G. F.; Faúndez-Abans, M.; Oliveira-Abans, M.

    2003-08-01

    Formulado no final da década de 50, o modelo de percolação concentra-se em descrever o meio poroso, que será visto neste trabalho como uma rede de canais aleatórios, por onde escoa um fluido determinístico. Se o número de canais for suficientemente grande, então eles estarão ligados e o meio se tornará permeável à passagem do fluido. Neste caso, dizemos que houve a percolação do fluido. Reformulando o modelo acima, podemos escrever um código particularmente adaptado para simulações em Galáxias, onde iremos supor que os canais formam um reticulado, e que cada sítio da rede representa um poro que será interpretado como uma região ativa de formação estelar. Para cada elo teremos um pequeno canal ligando dois sítios vizinhos, que poderá, após um tempo "t", induzir ou não a formação de uma região ativa no poro vizinho. Para simular a passagem desta região ativa através dos poros, diremos que um elo está aberto com probabilidade p e fechado com probabilidade 1-p. Dessa forma, passamos a imaginar configurações de elos abertos e fechados, onde cada configuração ocorre com uma certa probabilidade, dada por p|A|(1-p)|F|, onde |A| é o número de elos abertos e |F| o número de elos fechados da configuração. A expressão anterior só tem importância física se |A| e |F| forem ambos finitos, pois, caso contrário, a probabilidade de ocorrência de uma dada configuração será sempre nula. Neste trabalho, foram considerados dados cinemáticos publicados na literatura bem como aqueles obtidos pelos autores a partir de observações fotométricas realizadas no Observatório de Las Campanãs, em 1994, para a Galáxia Anelada Peculiar HRG 03401. Mostraremos que para certos valores de p, situados entre 0,5 e 0,6, os clusters assim formados irão simular, de maneira coerente, o referido objeto.

  13. Análise dos Conceitos Astronômicos Apresentados por Professores de Algumas Escolas Estaduais Brasileiras

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Gonzaga, Edson Pereira

    2011-12-01

    A razão para o desenvolvimento deste trabalho baseia-se no fato de que muitos professores da Educação Básica (EB) não lidam com conceitos relacionados à astronomia, e quando o fazem eles simplesmente seguem livros didáticos que podem conter erros conceituais. Como é de conhecimento geral a astronomia é um dos conteúdos a serem ensinados na EB fazendo parte dos Parâmetros Curriculares Nacionais e das Propostas Curriculares do Estado de São Paulo, mas é um fato, que vários pesquisadores apontam, a existência de muitos problemas no ensino da astronomia. Com o propósito de minimizar algumas dessas deficiências foi realizado um trabalho de pesquisa com a utilização de questionários pré e pós pesquisa, para tanto foi desenvolvido um Curso de Extensão Universitária para professores da Diretoria de Ensino Regional (DE) que abrange Mauá, Ribeirão Pires e Rio Grande da Serra (no Estado de São Paulo) com os seguintes objetivos: levantar concepções alternativas; subsidiar os professores por meio de palestras, debates e workshops, e verificar o sucesso da aprendizagem após o curso, adotando-se como referência, para a análise dos resultados, os dicionários de Língua Portuguesa (FERREIRA, 2004) e Enciclopédico de Astronomia e Astronáutica (MOURĀO, 1995). Portanto, dezesseis questões foram aplicadas antes e após o curso, assim pode-se verificar após a pesquisa que 100,0% dos professores sabiam os nomes das fases da Lua, 97,0% entenderam que o Sistema Solar é composto por oito planetas, 78,1% foram capazes de explicar como ocorre um eclipse lunar, um eclipse solar e um solstício, 72,7% sabiam como explicar a ocorrência das estações do ano; 64,5% explicaram corretamente a ocorrência do equinócio, 89,7% foram capazes de definir adequadamente o termo cometa; 63,6% definiram asteróide, 54,5% meteoro, 58,1% galáxia, e 42,4% planeta. Os resultados obtidos indicam uma aprendizagem significativa por parte dos participantes.

  14. Size Distribution and First Flush Effects of Mercury Containing Particles in Highway Runoff Water

    NASA Astrophysics Data System (ADS)

    Ferguson, K.; Green, P.

    2007-12-01

    Human and environmental health concerns have recently prompted many California water quality control boards to lower the Total Maximum Daily Loads (TMDL) of Mercury into their water systems. A size distribution study of mercury containing particles was conducted in order to begin to understand the possible sources of the contamination in highway storm water runoff. Four storms were studied from a monitoring site in the Los Angeles area near the crossing of highways 605 and 91. Storm water ran through an extended detention basin made of earthen material with a maximum water depth of 1.17m. Grab samples were collected manually starting at the beginning of the runoff, continuing at every fifteen minutes for the first hour, followed by a collection every hour after that for the duration of the storm. The particle sizes were separated into five size ranges (larger than 100um, 20-100um, 8-20um, 0.45-8um, and 0-0.45um) by sequential filtration. The samples were then acid digested for further analysis. Five standard Mercury solutions ranging from 5 to 100 parts per trillion were prepared in nitric acid immediately before analysis. Samples were analyzed for both the Hg-199 and the Hg-202 isotopes using an Agilent 7500i Inductively Coupled Plasma Mass Spectrometer. Substantial sub-micron concentrations of mercury were detected from all four storms, and in all five particle size ranges studied. The total amount of Mercury detected from each of the storms ranged from 8.5 to 35.5 pptr. Bursts of rain correlate well with increases of influent Hg concentration. Although a First Flush effect can be seen in the first storm, it is not as strong and/or not shown at all in the remaining three. The detention basin used at the site was shown to be an efficient BMP, reducing the amount of Hg in the effluent runoff as much as 30 pptr and down to as little as 2 pptr. The majority of Hg was found in either the 8-20um or the 0-0.45um particle size ranges. Mitigation of either portion will be challenging, but necessary to meet proposed 50 percent reductions.

  15. The merging dwarf galaxy UM 448: chemodynamics of the ionized gas from VLT integral field spectroscopy

    NASA Astrophysics Data System (ADS)

    James, B. L.; Tsamis, Y. G.; Barlow, M. J.; Walsh, J. R.; Westmoquette, M. S.

    2013-01-01

    Using Very Large Telescope/Fibre Large Array Multi Element Spectrograph optical integral field unit observations, we present a detailed study of UM 448, a nearby blue compact galaxy (BCG) previously reported to have an anomalously high N/O abundance ratio. New Technology Telescope/Superb-Seeing Imager images reveal a morphology suggestive of a merger of two systems of contrasting colour, whilst our Hα emission maps resolve UM 448 into three separate regions that do not coincide with the stellar continuum peaks. UM 448 exhibits complex emission line profiles, with most lines consisting of a narrow [full width at half-maximum (FWHM) ≲ 100 km s-1], central component, an underlying broad component (FWHM ˜ 150-300 km s-1) and a third, narrow blueshifted component. Radial velocity maps of all three components show signs of solid body rotation across UM 448, with a projected rotation axis that correlates with the continuum morphology of the galaxy. A spatially resolved, chemodynamical analysis, based on the [O iii] λλ4363, 4959, [N ii] λ6584, [S ii] λλ6716, 6731 and [Ne iii] λ3868 line maps, is presented. Whilst the eastern tail of UM 448 has electron temperatures (Te) that are typical of BCGs, we find a region within the main body of the galaxy where the narrow and broad [O iii] λ4363 line components trace temperatures differing by 5000 K and oxygen abundances differing by 0.4 dex. We measure spatially resolved and integrated ionic and elemental abundances for O, N, S and Ne throughout UM 448, and find that they do not agree, possibly due the flux weighting of Te from the integrated spectrum. This has significant implications for abundances derived from long-slit and integrated spectra of star-forming galaxies in the nearby and distant universe. A region of enhanced N/O ratio is indeed found, extended over a ˜0.6 kpc2 region within the main body of the galaxy. Contrary to previous studies, however, we do not find evidence for a large Wolf-Rayet (WR) population, and conclude that WR stars alone cannot be responsible for producing the observed N/O excess. Instead, the location and disturbed morphology of the N-enriched region suggest that interaction-induced inflow of metal-poor gas may be responsible.

  16. First Approach of Pneumatic Anthropomorphic Hand

    DTIC Science & Technology

    2001-10-25

    1 o f 3 FIRST APPROACH OF PNEUMATIC ANTHROPOMORPHIC HAND Jiménez, Omar; Leija, Lorenzo; Muñoz, Roberto Centro de Investigación y de Estudios...weight and minimum consumption, minimum control and natural appearance. Keywords- Anthropomorphic, hand, Pneumatic system, Prosthesis 1 . INTRODUCTION...The projects have been guided through an specific line of development. The project MARCUS[ 1 ] includes easiness as the most important aspect what

  17. Sistema de Vigilancia de Influenza de Puerto Rico |

    Science.gov Websites

    Rico VIH Publicaciones sobre la Salud Otras Publicaciones Registros Suicidio Tuberculosis Centro de Suicidio Tuberculosis Recent Ávisos Públicos Reglamentación Informe de Casos del Síndrome de Guillain Departamento de Salud de Puerto Rico Departamento de Salud Search... Search It looks like your

  18. The Women's Studies Center--A Women's-Led NGO Deepening Democracy in Chile: Educating Women through Personal Empowerment and Political Agency.

    ERIC Educational Resources Information Center

    King, Caroline

    This paper explores how the Women's Studies Center (Centro de Estudios de la Mujer, CEM), a feminist, women-led nongovernmental organization (NGO), is contributing to socio-cultural change in Chile 11 years after the country's democratic transition. CEM merges the theoretical and the practical, and the personal and the political through education…

  19. Summary Report on Visit to Departamento de Investigation Centro Ramon Y Cajal Madrid, Spain.

    DTIC Science & Technology

    1984-10-30

    Over one hundred colonies of Gram negative bacteria ( Lactobacillus acidophilus ) were cultured at 380 C in Petri dishes for 72 hours. The inoculum...within the various laboratories. He was particularly excited about studies using Lactobacillus bacteria and the work involving Drosophila melanogaster...therapy (0-40 Gauss) caUsed a 40 %reduction in the number of Lactobacillus colonies. ........................ . . .. . .. . .. . .. . . RAT MODEL TO

  20. A Counter Insurgency Study: An Analysis of Local Defenses

    DTIC Science & Technology

    2004-09-01

    Derrota de Sendero Luminoso; Programa Institucional de Investigación y Proyeccion en el Area de Gobernabilidad y Politica Publica, IEP ediciones...Corporation, Santa Monica CA. Kruijt, D. (1996), Sociedad de Terror: Guerrillas y Contrainsurgencia en Guatemala y El Peru; Cuadcien, Programa ... en El Salvador (1981 – 1992); Centro de Paz, El Latinoamericano; Retrieved on 7/16/2004 from http://www.stormpages.com/marting/laguerrasalvador.htm

  1. Technology Outlook for STEM+ Education 2013-2018: An NMC Horizon Project Sector Analysis

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Martín, S.

    2013-01-01

    The "Technology Outlook for STEM+ Education 2013-2018: An NMC Horizon Project Sector Analysis" reflects a collaborative research effort between the New Media Consortium (NMC), the Centro Superior para la Enseñanza Virtual (CSEV), the Departamento de Ingeniería Eléctrica, Electrónica y de Control at the Universidad Nacional de Educación a…

  2. Attivita del Centro di Linguistica Applicata nel campo della lingua e della cultura italiana all'estero (Activities of the Italian Center for Applied Linguistics concerning Italian Language and Culture Abroad).

    ERIC Educational Resources Information Center

    Boriosi Katerinov, Maria Clotilde

    1979-01-01

    Outlines the activities of a recently created section of the Italian Center for Applied Linguistics (CILA), dealing with "Teaching Italian Abroad." Describes these activities as encompassing four areas: research, teaching methodology, consultation, teachers' training and bibliographical information. Lists statistical surveys, research papers, and…

  3. Beyond the Borders: A Partnership between U.S. and Mexican Schools for Students Who Are Visually Impaired. Practice Report

    ERIC Educational Resources Information Center

    Wood, Jackie; Poel, Elissa Wolfe

    2006-01-01

    Since 2002, the New Mexico School for the Blind and Visually Impaired (NMSBVI) in Alamogordo, New Mexico, has worked to create a partnership with the "Centro de Capacitacion para Invidentes" in Durango, Mexico, and the "Instituto de Asesoria y Apoyo para Ciegor" in Ciudad Juarez, Mexico. The purpose of this association was to…

  4. The Role of Iron in Libby Amphibole-Induced Lung Injury and Inflammation

    EPA Science Inventory

    Complexation of host iron (Fe) on the surface of inhaled asbestos fibers has been postulated to cause oxidative stress contributing to in vivo pulmonary injury and inflammation. We examined the role of Fe in Libby amphibole (LA; mean length 4.99um ± 4.53 and width 0.28um ± 0.19)...

  5. "Uh," "Um," and Autism: Filler Disfluencies as Pragmatic Markers in Adolescents with Optimal Outcomes from Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Irvine, Christina A.; Eigsti, Inge-Marie; Fein, Deborah A.

    2016-01-01

    Filler disfluencies--"uh" and "um"--are thought to serve distinct discourse functions. We examined fillers in spontaneous speech by youth with autism spectrum disorder (ASD), who struggle with pragmatic language, and by youth with ASD who have achieved an "optimal outcome" (OO), as well as in peers with typical…

  6. Chinese/Chinese American Students at the University of Mississippi from 1946 to 1975

    ERIC Educational Resources Information Center

    Kao, Hsin-Yi

    2012-01-01

    The historical integration of the University of Mississippi (UM) brought both national and local attention when James Meredith was escorted by U.S. Marshals to enroll and attend classes on October 1, 1962 (Cohodas, 1997; Doyle, 2001; Eagles, 2009). Since the integration of UM, racial issues and efforts to promote racial reconciliation primarily…

  7. USING CERAMIC MEMBRANES TO RECYCLE TWO NONIONIC ALKALINE METAL-CLEANING SOLUTIONS

    EPA Science Inventory

    One ZrO2 ultrafilter (0.05 um pore size) and two a-Al2O3 microfilters (0.2 and 0.8 um) were used to remove one synthetic ester oil and two polyalphaolefin-based and two petroleum hydrocarbon-based oils and greases from two nonionic alkaline cleaning solutions (e.g., Turco 4215-NC...

  8. DETERMINING COARSE PARTICULATE MATTER CONCENTRATIONS: A PERFORMANCE EVALUATION OF CANDIDATE METHODOLOGIES - STUDY DESIGN AND RESULTS FROM THE RTP EQUIPMENT SHAKEDOWN

    EPA Science Inventory

    The main objective of this study is to evaluate the performance of candidate sampling methods for potential use as a Federal Reference Method (FRM) capable of providing an estimate of coarse particle (PMc: particulate matter with an aerodynamic diameter between 2.5 um and 10 um...

  9. Accurate measurement of the first excited nuclear state in 235U

    NASA Astrophysics Data System (ADS)

    Ponce, F.; Swanberg, E.; Burke, J.; Henderson, R.; Friedrich, S.

    2018-05-01

    We have used superconducting high-resolution radiation detectors to measure the energy level of metastable Um235 as 76.737 ± 0.018 eV. The Um235 isomer is created from the α decay of 239Pu and embedded directly into the detector. When the Um235 subsequently decays, the energy is fully contained within the detector and is independent of the decay mode or the chemical state of the uranium. The detector is calibrated using an energy comb from a pulsed UV laser. A comparable measurement of the metastable Thm229 nucleus would enable a laser search for the exact transition energy in 229Th-Thm229 as a step towards developing the first ever nuclear (baryonic) clock.

  10. VizieR Online Data Catalog: SG1120-1202 members HST imaging & 24um fluxes (Monroe+, 2017)

    NASA Astrophysics Data System (ADS)

    Monroe, J. T.; Tran, K.-V. H.; Gonzalez, A. H.

    2017-09-01

    We employ HST imaging of an ~8'x12' mosaic across three filters: F390W (WFC3/UVIS), F606W (ACS/WFC), and F814W (ACS/WFC) for a total of 44 pointings (combined primary and parallels) during cycles 14 (GO 10499) and 19 (GO 12470). We use the Spitzer MIPS 24um fluxes from Saintonge+ (2008ApJ...685L.113S) and Tran+ (2009ApJ...705..809T). The 24um observations were retrieved from the Spitzer archive. For details on spectroscopy from multi-band ground-based observations using Magellan (in 2006), MMT, and VLT/VIMOS (in 2003), we refer the reader to Tran+ (2009ApJ...705..809T). (1 data file).

  11. VizieR Online Data Catalog: Candidate stellar bowshock nebulae from MIR (Kobulnicky+, 2016)

    NASA Astrophysics Data System (ADS)

    Kobulnicky, H. A.; Chick, W. T.; Schurhammer, D. P.; Andrews, J. E.; Povich, M. S.; Munari, S. A.; Olivier, G. M.; Sorber, R. L.; Wernke, H. N.; Dale, D. A.; Dixon, D. M.

    2017-01-01

    Our team conducted a visual examination of mid-infrared images from SST and the WISE to locate bowshock nebula candidates. The SST data included several wide-area surveys conducted using the Infrared Array Camera (IRAC) in its 3.6, 4.5, 5.8, and 8.0um bandpasses, along with 24um data from the Multiband Imaging Photometer for Spitzer (MIPS). The SST beam size at these bands is 1.66, 1.72, 1.88, 1.98, and 6" FWHM, respectively. The WISE data include images at the 3.4, 4.6, 12, and 22um bandpasses, which have beam sizes of 6.1, 6.4, 6.5, and 12" FWHM, respectively. (1 data file).

  12. Novel papillomavirus isolated from the oral mucosa of a polar bear does not cluster with other papillomaviruses of carnivores.

    PubMed

    Stevens, Hans; Rector, Annabel; Bertelsen, Mads F; Leifsson, Pall S; Van Ranst, Marc

    2008-05-25

    Papillomatosis has been documented in several carnivores, and papillomavirus (PV) types have been characterized from lesions in a number of carnivore species: the canine oral PV (COPV), the Felis domesticus PV type 1 (FdPV-1) isolated from a Persian cat, the Procyon lotor PV type 1 (PlPV-1) isolated from a raccoon, the canine PV type 2 (CPV-2) from a dog's foot pad lesion and the canine PV type 3 (CPV-3) associated with a canine epidermodysplasia verruciformis - like disease. A tissue sample was taken from a papillomatous lesion on the oral mucosa of a polar bear (Ursus maritimus). Extracted DNA was used as a template for multiply primed rolling-circle amplification (RCA), and restriction enzyme analysis of the RCA product indicated the presence of papillomaviral DNA. The genome of this PV was cloned and the complete genomic sequence was determined. The Ursus maritimus PV type 1 (UmPV-1) genome counts 7582 basepairs and is smaller than that of other papillomaviruses from carnivore species. UmPV-1 contains the typical noncoding region NCR1, but unlike the carnivore PVs of the Lambda genus, UmPV-1 does not possess a second noncoding region NCR2. Phylogenetic analysis based on a nucleotide sequence alignment of the L1 ORF of UmPV-1 and 51 other PV types indicates that UmPV-1 does not cluster with any of the other carnivore PVs, but branches off near the root of the common branch of the genus Alphapapillomavirus.

  13. Development of an Inline Urine Monitoring System for the International Space Station

    NASA Technical Reports Server (NTRS)

    Broyan, James Lee, Jr.; Cibuzar, Banelle R.

    2008-01-01

    Human exposure to microgravity during spaceflight causes bone loss. Calcium and other metabolic byproducts are excreted in urine voids. Frequent and accurate measurement of urine void volume and constituents is essential to determining crew bone loss and the effectiveness of countermeasures. Previous US Space Shuttle (SS) Urine Monitoring System (UMS) technology was unable to accurately measure urine void volumes due to cross contamination between users and fluid system instabilities. Currently, urine voids must be collected manually in a flexible plastic bag containing a known tracer quantity. The crew member must completely mix the bag then withdraw a representative syringe sample for later ground analysis. The current bag system accuracy is highly dependent on mixing technique. The International Space Station (ISS) UMS has been developed as an automated device that collects urine from the Waste and Hygiene Compartment (WHC) urinal funnel interface, separates the urine, measures the void volume, and allows for syringe sampling. After operations, the ISS UMS delivers the urine to the WHC for normal processing then flushes its plumbing with a small water volume. The current ISS UMS design incorporates an innovative rotary separator that minimizes foaming, greatly reduces cross contamination between urine voids (< 0.5 ml urine), and provides accurate volume measurements (< +/- 2% error for 100 to 1000 ml void volumes). The system performance has been validated with extensive ground tests and reduced gravity aircraft flights. The lockersized ISS UMS is currently being modified to interface with the ISS Node 3 WHC Russian ACY hardware. The operation principles, characteristics, and results are outlined in the paper.

  14. Long-Term Satisfaction and Body Image After Contralateral Prophylactic Mastectomy.

    PubMed

    Anderson, Chelsea; Islam, Jessica Y; Elizabeth Hodgson, M; Sabatino, Susan A; Rodriguez, Juan L; Lee, Clara N; Sandler, Dale P; Nichols, Hazel B

    2017-06-01

    Contralateral prophylactic mastectomy (CPM) rates have been increasing in the US, and although high levels of satisfaction with CPM have been reported, few studies have evaluated the long-term effects on body image, comparing CPM with breast-conserving surgery (BCS) and unilateral mastectomy (UM). We analyzed responses from a survey of women with both a personal and family history of breast cancer who were enrolled in the Sister Study (n = 1176). Among women who underwent mastectomy, we examined satisfaction with the mastectomy decision, as well as variation in the use of reconstruction and experience of complications. Five survey items, evaluated individually and as a summed total score, were used to compare body image across surgery types (BCS, UM without reconstruction, CPM without reconstruction, UM with reconstruction, and CPM with reconstruction). Participants were, on average, 3.6 years post-diagnosis at the time of survey (standard deviation 1.7). The majority of women (97% of CPM, 89% of UM) were satisfied with their mastectomy decision. Reconstruction was more common after CPM than after UM (70 vs. 47%), as were complications (28 vs. 19%). Body image scores were significantly worse among women who underwent CPM than among women who underwent BCS, with the lowest scores among women who underwent CPM without reconstruction. In our sample, most women were highly satisfied with their mastectomy decision, including those who elected to undergo CPM. However, body image was lower among those who underwent CPM than among those who underwent BCS. Our findings may inform decisions among women considering various courses of surgical treatment.

  15. An Uncertainty Structure Matrix for Models and Simulations

    NASA Technical Reports Server (NTRS)

    Green, Lawrence L.; Blattnig, Steve R.; Hemsch, Michael J.; Luckring, James M.; Tripathi, Ram K.

    2008-01-01

    Software that is used for aerospace flight control and to display information to pilots and crew is expected to be correct and credible at all times. This type of software is typically developed under strict management processes, which are intended to reduce defects in the software product. However, modeling and simulation (M&S) software may exhibit varying degrees of correctness and credibility, depending on a large and complex set of factors. These factors include its intended use, the known physics and numerical approximations within the M&S, and the referent data set against which the M&S correctness is compared. The correctness and credibility of an M&S effort is closely correlated to the uncertainty management (UM) practices that are applied to the M&S effort. This paper describes an uncertainty structure matrix for M&S, which provides a set of objective descriptions for the possible states of UM practices within a given M&S effort. The columns in the uncertainty structure matrix contain UM elements or practices that are common across most M&S efforts, and the rows describe the potential levels of achievement in each of the elements. A practitioner can quickly look at the matrix to determine where an M&S effort falls based on a common set of UM practices that are described in absolute terms that can be applied to virtually any M&S effort. The matrix can also be used to plan those steps and resources that would be needed to improve the UM practices for a given M&S effort.

  16. Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing.

    PubMed

    Linares, Oscar A; Fudin, Jeffrey; Daly, Annemarie L; Boston, Raymond C

    2015-12-01

    (1) To quantify hydrocodone (HC) and hydromorphone (HM) metabolite pharmacokinetics with pharmacogenetics in CYP2D6 ultra-rapid metabolizer (UM), extensive metabolizer (EM), and poor metabolizer (PM) metabolizer phenotypes. (2) To develop an HC phenotype-specific dosing strategy for HC that accounts for HM production using clinical pharmacokinetics integrated with pharmacogenetics for patient safety. In silico clinical trial simulation. Healthy white men and women without comorbidities or history of opioid, or any other drug or nutraceutical use, age 26.3±5.7 years (mean±SD; range, 19 to 36 y) and weight 71.9±16.8 kg (range, 50 to 108 kg). CYP2D6 phenotype-specific HC clinical pharmacokinetic parameter estimates and phenotype-specific percentages of HM formed from HC. PMs had lower indices of HC disposition compared with UMs and EMs. Clearance was reduced by nearly 60% and the t1/2 was increased by about 68% compared with EMs. The canonical order for HC clearance was UM>EM>PM. HC elimination mainly by the liver, represented by ke, was reduced about 70% in PM. However, HC's apparent Vd was not significantly different among UMs, EMs, and PM. The canonical order of predicted plasma HM concentrations was UM>EM>PM. For each of the CYP2D6 phenotypes, the mean predicted HM levels were within HM's therapeutic range, which indicates HC has significant phenotype-dependent pro-drug effects. Our results demonstrate that pharmacogenetics afford clinicians an opportunity to individualize HC dosing, while adding enhanced opportunity to account for its conversion to HM in the body.

  17. Assessment of the University of Michigan's dental hygiene partnership with the Huron Valley Boys & Girls Club: a study of students' and staffs' perceptions and service learning outcomes.

    PubMed

    Christensen Brydges, Sarah; Gwozdek, Anne E

    2011-01-01

    The Boys & Girls Club of America (BGCA) requires a health curriculum be taught. With the assistance of the University of Michigan (UM) Dental Hygiene program, these requirements have been addressed at the Huron Valley Boys & Girls Club (HVBGC) through dental hygiene students presenting oral health education to club members throughout the year. This study assessed the outcomes and benefits of the service learning initiative between the UM Dental Hygiene Program and the HVBGC from both the students' and staffs' perceptions. Three surveys were distributed: one to the HVBGC staff, one to UM's Dental Hygiene class of 2012 (with no service learning experience at the HVBGC) and one to UM Dental Hygiene classes of 2010 and 2011 (most of whom had experience at the HVBGC). Qualitative and quantitative data were collected and evaluated. The respondents from the class of 2012 were less knowledgeable about the BGCA and access to care issues. The members of the classes of 2010 and 2011, 79% of whom had HVBGC experience, identified they had benefitted from this service learning experience. The HVBGC staff survey indicated a high level of satisfaction with the student presentations and felt their curricular requirements were being met. Future topics of safety, orthodontics and gardening/nutrition were identified. This study indicates the service learning initiative has been beneficial for both the UM Dental Hygiene students and the HVBGC. Future studies should use a longitudinal design to obtain baseline and post-service learning data.

  18. Protocol for Automated Zooplankton Analysis

    DTIC Science & Technology

    2010-01-01

    on maximum dimension on the smallest axis: organisms > 50 microns (urn) (nominally zooplankton), organisms > 10 um to < 50 um (nominally protists ...viability of protists . Recent work has focused on performing measurements at a variety of geographic locations to demonstrate that these stains...provide a location-independent means to identify viable protists in test samples. NRL recommends staining samples with a combination of two vital stains

  19. "Um, I Can Tell You're Lying": Linguistic Markers of Deception versus Truth-Telling in Speech

    ERIC Educational Resources Information Center

    Arciuli, Joanne; Mallard, David; Villar, Gina

    2010-01-01

    Lying is a deliberate attempt to transmit messages that mislead others. Analysis of language behaviors holds great promise as an objective method of detecting deception. The current study reports on the frequency of use and acoustic nature of "um" and "like" during laboratory-elicited lying versus truth-telling. Results obtained using a…

  20. Study Abroad for Chinese University Presidents: How China Is Reforming Higher Education

    ERIC Educational Resources Information Center

    Cook, Constance Ewing

    2008-01-01

    In 2006, the Chinese Ministry of Education sent presidents and party secretaries from its top-ranked universities to the University of Michigan (UM) to learn more about the leadership of research universities. Both the ministry and UM worked hard to make the visit productive, and both parties gained from it. A year later, with the support of the…

  1. Elektroakustische Wandler

    NASA Astrophysics Data System (ADS)

    Plaßmann, Wilfried

    Um Sprache und Musik über größere Entfernungen zu übertragen, wird der Hörschall mit einem Mikrofon in ein proportionales elektrisches Signal umgewandelt und auf drahtlosem Wege (Beispiel Rundfunkübertragung) oder drahtgebunden (Beispiel Telefon, Kabelrundfunk, oft in Kombination mit dem drahtlosen Weg) zum Empfänger übermittelt. Am Empfangsort setzt z. B. ein Lautsprecher das elektrische Signal wieder in ein akustisches Signal um.

  2. User Modeling in Adaptive Hypermedia Educational Systems

    ERIC Educational Resources Information Center

    Martins, Antonio Constantino; Faria, Luiz; Vaz de Carvalho, Carlos; Carrapatoso, Eurico

    2008-01-01

    This document is a survey in the research area of User Modeling (UM) for the specific field of Adaptive Learning. The aims of this document are: To define what it is a User Model; To present existing and well known User Models; To analyze the existent standards related with UM; To compare existing systems. In the scientific area of User Modeling…

  3. THE BIMODAL DISTRIBUTION: DEVELOPMENT OF THE CONCEPT OF FINE AND COARSE PARTICLES AS SEPARATE AND DISTINCT COMPONENTS OF AIRBORNE PARTICULATE MATTER

    EPA Science Inventory

    In the early 1970s, it was understood that combustion particles were formed mostly in sizes below 1 um diameter, and windblown dust was suspended in sizes mostly above 1 um diameter. However, particle size distribution was thought of as a single mode. Particles were thought to f...

  4. VizieR Online Data Catalog: Multiwavelenght photometry of Sh 2-138 YSOs (Baug+, 2015)

    NASA Astrophysics Data System (ADS)

    Baug, T.; Ojha, D. K.; Dewangan, L. K.; Ninan, J. P.; Bhatt, B. C.; Ghosh, S. K.; Mallick, K. K.

    2016-07-01

    Optical BVRI imaging observations of the Sh2-138 region were carried out on 2005 September 8 using the Himalaya Faint Object Spectrograph and Camera (HFOSC) mounted on the 2 m Himalayan Chandra Telescope (HCT). In order to identify strong Hα emission sources in the Sh2-138 region, slitless Hα spectra were obtained using the HFOSC on 2007 November 16. Optical spectroscopic observations of the central brightest source were performed using the HFOSC on 2014 November 18. The newly installed TIFR Near Infrared Spectrometer and Imager Camera (TIRSPEC) on the HCT was used for NIR observations on 2014 November 18 under photometric conditions with an average seeing of 1.4 arcsec. We obtained NIR spectra of the central brightest source on 2014 May 29, using the TIRSPEC, in NIR Y (1.02-1.20um), J (1.21-1.48um), H (1.49-1.78um), and K (2.04-2.35um) bands. We conducted optical narrow-band imaging observations of the region in Hα filter (λ~6563Å, Δλ~100Å) with exposure times of 600s, 250s, and 50s on 2005 September 8 using the HFOSC. (1 data file).

  5. Electrohydrodynamic inkjet printing of Pd loaded SnO2 nanofibers on a CMOS micro hotplate for low power H2 detection

    NASA Astrophysics Data System (ADS)

    Wu, Hao; Yu, Jun; Cao, Rui; Yang, Yinghua; Tang, Zhenan

    2018-05-01

    A high-performance low-power micro hotplate (MHP) hydrogen sensor was fabricated through electrohydrodynamic (EHD) inkjet printing technique. Electrospun Pd loaded SnO2 nanofibers with lengths of 250-850 nm were precisely printed on the suspended central part of an MHP with an area of 100 um × 100 um. The printhead in the printing system was a low-cost metallic needle with an inner diameter of 110 um, which was large enough to prevent clogging by the nanofibers. The printing process was observed by a high-speed camera. Small droplets with diameters of 50-80 um were produced at each ejection by providing a high voltage to the metallic needle. It was found that the bridge-type MHPs used in our experiment can promote the positioning precision due to its bound effect to the droplet. In the gas sensing measurement, the Pd loaded SnO2 MHP gas sensor showed a remarkable response to H2 with a low power of only 9.1 mW. The experiment results demonstrate the excellent adequacy of EHD inkjet printing technique to realize effective mass fabrication of MHP gas sensors or sensor arrays.

  6. Processes of conscious and unconscious memory: evidence from current research on dissociation of memories within a test.

    PubMed

    Cheng, Chao-Ming; Huang, Chin-Lan

    2011-01-01

    The processes of conscious memory (CM) and unconscious memory (UM) are explored, based on the results of the current and previous studies in which the 2 forms of memory within a test were separated by either the process dissociation or metacognition-based dissociation procedure. The results assessing influences of shallow and deep processing, association, and self-generation on CM in explicit and implicit tests are taken as evidence that CM in a test is driven not only conceptually but also by the driving nature of the test, and CM benefits from an encoding condition to the extent that information processing for CM recapitulates that engaged in the encoding condition.Those influences on UM in explicit and implicit tests are taken to support the view that UM in a test is driven by the nature of the test itself, and UM benefits from an encoding condition to the extent that the cognitive environments at test and at study match to activate the same type of information (e.g., visual, lexical, or semantic) about memory items or the same content of a preexisting association or categorical structure.

  7. Hydrothermal alteration mapping using ASTER data in Baogutu porphyry deposit, China

    NASA Astrophysics Data System (ADS)

    Li, Q.; Zhang, B.; Lu, L.; Lin, Q.

    2014-03-01

    Remote sensing plays an important role in mineral exploration. One of its proven applications is extracting host-rock lithology and alteration zones that are related to porphyry copper deposits. An Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) was used to map the Baogutu porphyry deposit alteration area. A circular alteration mineral zoning pattern was clearly observed in the classification result of potassic, phyllic, argillic, propylitic zones. The potassic is characterized by biotite and anhydrite with an absorption feature centered at 1.94 and 2.1um. The phyllic zone is characterized by illite and sericite that indicates an intense Al-OH absorption feature centered at 2.20um. The narrower argillic zone including kaolinite and alunite displays a secondary Al-OH absorption feature at 2.17 um. The mineral assemblages of the outer propylitic zone are epidote, chlorite and calcite that exhibit absorption features at 2.335um.The performance of Principal Component Analysis(PCA), Minimum Noise Fraction (MNF), band ratio(BR) and Constrained Energy Minimization(CEM) has been evaluated. These techniques identified new prospects of porphyry copper mineralization in the study areas. These results indicate that ASTER is a powerful tool in the initial steps of mineral exploration.

  8. Life-cycle optimization model for distributed generation in buildings

    NASA Astrophysics Data System (ADS)

    Safaei, Amir

    O setor da construcao e responsavel por uma grande parte do consumo de energia e emissoes na Uniao Europeia. A Geracao Distribuida (GD) de energia, nomeadamente atraves de sistemas de cogeracao e tecnologias solares, representa um papel importante no futuro energetico deste setor. A otimizacao do funcionamento dos sistemas de cogeracao e uma tarefa complexa, devido as diversas variaveis em jogo, designadamente: os diferentes tipos de necessidades energeticas (eletricidade, aquecimento e arrefecimento), os precos dinamicos dos combustiveis (gas natural) e da eletricidade, e os custos fixos e variaveis dos diferentes sistemas de GD. Tal torna-se mais complexo considerando a natureza flutuante das tecnologias solares termicas e fotovoltaicas. Ao mesmo tempo, a liberalizacao do mercado da eletricidade permite exportar para a rede, a electricidade gerada localmente. Adicionalmente, a operacao estrategica de um sistema de GD deve atender aos quadros politicos nacionais, se tiver como objetivo beneficiar de tais regimes. Alem disso, considerando os elevados impactes ambientais do setor da construcao, qualquer avaliacao energetica de edificios rigorosa deve tambem integrar aspetos ambientais, utilizando uma abordagem de Ciclo de Vida (CV). Uma avaliacao de Ciclo de Vida (ACV) completa de um sistema de GD deve incluir as fases relativas a operacao e construcao do sistema, bem como os impactes associados a producao dos combustiveis. Foram analisadas as emissoes da producao de GN, as quais variam de acordo com a origem, tipo (convencional ou nao-convencional), e estado (na forma de GN Liquefeito (GNL) ou gas). Do mesmo modo, o impacte dos sistemas solares e afetado pela meteorologia e radiacao solar, de acordo com a sua localizacao geografica. Sendo assim, uma avaliacao adequada dos sistemas de GD exige um modelo de ACV adequado a localizacao geografica (Portugal), integrando tambem a producao de combustivel (GN), tendo em conta as suas diferentes fontes de abastecimento. O principal objetivo desta tese de doutoramento foi desenvolver um modelo para otimizar o desenho e operacao de sistemas de GD para o setor da construcao de edificios comerciais em Portugal, considerando os respetivos Impactes de Ciclo de Vida (IAVC) e Custos de Ciclo de Vida (CCV), de modo a satisfazer as necessidades energeticas do edificio. Tres tipos de tecnologias de cogeracao (Micro-Turbinas, Motores de combustao interna, e Celulas combustiveis de Oxido solido), e dois tipos de tecnologias de energia solar, solar termica e fotovoltaica, constituem os sistemas de GD que sao acoplados aos sistemas convencionais. Foi desenvolvido um modelo de CV, tendo em conta todos os impactes relacionados com a construcao e operacao dos sistemas de energia, bem como os processos a montante relacionados com a producao do GN. Em particular, o mix de GN consumido em Portugal em 2011 foi identificado (60% da Nigeria, 40% da Argelia) e os impactes relativos a cada uma das vias de abastecimento foram avaliados separadamente para quatro categorias de impacte ambiental: Consumo de Energia Primaria (CEP), Gases com Efeito de Estufa (GEE), acidificacao, e eutrofizacao. Devido a importancia das emissoes de GEE na formulacao de politicas, foi tambem realizada uma analise de incerteza as emissoes de GEE do GN fornecido a Portugal. Foi desenvolvido um modelo matematico, em linguagem de Programacao General Algebraic Modeling System (GAMS), que utiliza os resultados da ACV dos sistemas de energia e as suas implicacoes economicas para minimizar o CCV e IACV ao longo de um horizonte de planeamento definido pelo decisor. Foram derivadas fronteiras otimas de Pareto, representando as relacoes entre o tipo de IACV (CEP, GEE, acidificacao, eutrofizacao) e CCV decorrentes da satisfacao das necessidades energeticas do edificio. Para aumentar a robustez do modelo, dada a incerteza dos precos dos combustiveis (GN e eletricidade), foi desenvolvido um modelo de custos robusto para os sistemas de GD, que e menos afetado por perturbacoes relativas aos custos de combustivel. A aplicacao do modelo proposto foi testada num caso de estudo real, um edificio comercial localizado na cidade de Coimbra, em Portugal.

  9. Developing a Partnership with Brazil - An Emerging Power

    DTIC Science & Technology

    2004-03-19

    with the purpose of better preparing their troops for this type of operation. The Centro Argentino de Entrenamiento Conjunto para Fuerza de Paz...definitively tying the Fuerzas Armadas Revolucionarias de Colombia (FARC) with drug dealing73 is convincing Brazilian policymakers that what is happening in...in terms of military intelligence in the region with the use of the recently installed apparatus of the Amazon Surveillance System (Sistema de

  10. Cholesteric Liquid Crystal Glass Platinum Acetylides

    DTIC Science & Technology

    2014-06-01

    M. Krein AFRL/RXAP Ronald F. Ziolo, Eduardo Arias, and Ivana Moggio 2Centro de Investigacion en Quimica Aplicada(CIQA) Albert Fratini...estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the...valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) June 2014 2. REPORT TYPE Interim 3

  11. New gas-pipeline system planned for Argentina

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Andrich, V.

    1979-03-01

    A new gas-pipeline system planned for Argentina by Gas del Estado will carry up to 10 million cu m/day to Mendoza, San Juan, and San Luis from the Neuquen basin. Operating on a toll system of transport payment, the Centro-Oeste pipeline system will consist of 1100 km of over 30 in. dia trunk line and 600 km of 8, 12, and 18 in. dia lateral lines.

  12. Energia Renovable para Centros de Salud Rurales (Renewable Energy for Rural Health Clinics) (in Spanish)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jimenez, T.; Olson, K.

    Esta es la primera de una serie de guias de aplicaciones que el Programa de Energia de Villas de NREL esta comisionando para acoplar sistemas comerciales renovables con aplicaciones rurales, incluyendo agua, escuelas rurales y micro empresas. La guia esta complementada por las actividades de desarrollo del Programa de Energia de Villas de NREL, proyectos pilotos internacionales y programas de visitas profesionales.

  13. Sierpinski and Carmichael Numbers

    DTIC Science & Technology

    2013-01-16

    Carrie Finch Mathematics Department Washington and Lee University Lexington, VA 24450, USA finchc@wlu.edu Florian Luca Centro de Matemáticas...Universidad Nacional Autónoma de México C.P. 58089, Morelia, Michoacán, México fluca@matmor.unam.mx Carl Pomerance Department of Mathematics Dartmouth...Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any

  14. The William Perry Center for Hemispheric Defense Studies (The Perry Center)

    Science.gov Websites

    de usuario multilingüe para sus visitantes, y consolidará el contenido que solía extenderse a sites. * * * 21 septiembre, 2017 El Centro William J. Perry se complace en anunciar su nuevo hogar virtual. La nueva página, ubicada en [http://williamjperrycenter.org], ofrece una verdadera experiencia

  15. Effective Measurement of Reliability of Repairable USAF Systems

    DTIC Science & Technology

    2012-09-01

    Hansen presented a course, Concepts and Models for Repairable Systems Reliability, at the 2009 Centro de Investigacion en Mathematicas ( CIMAT ). The...recurrent event by calculating the mean quantity of recurrent events of the population of systems at risk at that point in time. The number of systems at... risk is the number of systems that are operating and providing information. [9] Information can be obscured by data censoring and truncation. One

  16. Mexico: Centro de Documentacion e Informacion Educativa. Seminario de Documentacion e Informacion Pedagogica en America Latina (The Mexican Center for Educational Documentation and Information. Working Paper for the Seminar on Educational Documentation and Information in Latin America).

    ERIC Educational Resources Information Center

    Secretaria de Educacion Publica, Mexico City (Mexico). Centro de Documentacion e Informacion Educativa.

    This document describes the Center for Documentation and Educational Information in Mexico City. Background information on similar services in Mexico is provided and a detailed description of the Center is presented, covering organization, objectives, administration, users, activities, services, and publications. (VM)

  17. Argentine Civil-Military Relations. From Alfonsin to Menem

    DTIC Science & Technology

    2002-11-01

    America has modernized considerably in the 20th cen- tury, many fundamental attitudes, beliefs, and sentiments inculcated by 300 years of Spanish or...applied to the Spanish military. (See table 1.) This NATURE OF CIVIL–MILITARY RELATIONS 19 differentiation of military roles as expressed in the...Argentine (Institution) Revolution (’66) and Proceso (’76) Source: Rosendo Fraga, La cuestión militar, 1987–1989 (Buenos Aires: Editorial Centro de

  18. Puerto Ricans and Higher Education Policies. Volume 1: Issues of Scholarship, Fiscal Policies and Admissions. Higher Education Task Force Discussion Series.

    ERIC Educational Resources Information Center

    Rodriguez, Camille, Ed.; Bosque-Perez, Ramon, Ed.

    This volume explores issues of scholarship, fiscal policies, and admissions in the higher education of Puerto Ricans, with the emphasis on Puerto Ricans on the U.S. mainland and a particular focus on Puerto Rican admissions to the City University of New York. The first paper, "The Centro's Models of Scholarship: Present Challenges to Twenty…

  19. Study of the Electrical Impedance Scanning

    DTIC Science & Technology

    2001-10-25

    extremely promising technique to complement other conventional image examinations. Areas presenting abnormalities and/or malignant neoplasia evidence...presenting abnormalities and/or malignant neoplasia evidence exhibit conductive changes (in the structure of cell’s membrane, in its permeability, in the...Calas , R. R. de Cas and V. R Manoel , “Scanning de Impedância Transpectral Elétrica da Mama ”, CEPEM – Centro de Estudos e Pesquisas da Mulher

  20. [Late primary abdominal pregnancy. Case report].

    PubMed

    Farías, Emigdio Torres; Gómez, Luis Guillermo Torres; Allegre, René Márquez; Higareda, Salvador Hernández

    2008-09-01

    Abdominal advanced pregnancy is an obstetric complication that put at risk maternal and fetal life. We report a case of advanced abdominal pregnancy with intact ovaries and fallopian tubes, without ureteroperitoneal fistulae and, late prenatal diagnosis, in a multiparous patient without risk factors, with alive newborn, and whose pregnancy was attended at Unidad Medica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Medico Nacional de Occidente del IMSS, Guadalajara, Jalisco, México.

  1. Special Session on Adaptive Optics in Russia and China. Volume 23

    DTIC Science & Technology

    1995-01-01

    Fisica Aplicada. Universidad de Cantabria. 39005. SANTANDER. SPAIN. Tel: 42-201445. Fax: 42-201402. 1.- INTRODUCTION To estimate the centroid of a light...Lia M. Zerbino ##, Eduardo Aguirre +, Anibal P. Laquidara ++ and Mario-Garavaglia ft. Centro de Investigaciones Opticas (CIOp) CC 124 Correo Central...Professor at Universidad Nacional dt La Plata and CONICET Engiuneer. C (lOp belongs to Consejo Nacional de Investigaciones Cientificas y Ticnicas (CONICET

  2. Immune Responses and Protection of Aotus Monkeys Immunized with Irradiated Plasmodium vivax Sporozoites

    DTIC Science & Technology

    2011-01-01

    The experimental protocol was approved by the Animal Ethical Committee of the Universidad del Valle (Cali). Parasite and irradiation. Plasmodium...three repeats ofpll (GDRADGPA) and (ANGAGNQPG) sequences, derived from VK210 and VK247 CS variants, respectively. A non-malaria related peptide Ptt30...Universidad del Valle and Centro Internacional de Vacunas, Cali, Colombia, E-mails: alejovi@hotmail.com, anbonelo@yahoo.com, alejcaste@yahoo.com

  3. Acute Biphasic Effects of Ayahuasca.

    PubMed

    Schenberg, Eduardo Ekman; Alexandre, João Felipe Morel; Filev, Renato; Cravo, Andre Mascioli; Sato, João Ricardo; Muthukumaraswamy, Suresh D; Yonamine, Maurício; Waguespack, Marian; Lomnicka, Izabela; Barker, Steven A; da Silveira, Dartiu Xavier

    2015-01-01

    Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of electroencephalogram (EEG) recordings and quantification of ayahuasca's compounds and their metabolites in the systemic circulation we found ayahuasca to induce a biphasic effect in the brain. This effect was composed of reduced power in the alpha band (8-13 Hz) after 50 minutes from ingestion of the brew and increased slow- and fast-gamma power (30-50 and 50-100 Hz, respectively) between 75 and 125 minutes. Alpha power reductions were mostly located at left parieto-occipital cortex, slow-gamma power increase was observed at left centro-parieto-occipital, left fronto-temporal and right frontal cortices while fast-gamma increases were significant at left centro-parieto-occipital, left fronto-temporal, right frontal and right parieto-occipital cortices. These effects were significantly associated with circulating levels of ayahuasca's chemical compounds, mostly N,N-dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine and some of their metabolites. An interpretation based on a cognitive and emotional framework relevant to the ritual use of ayahuasca, as well as it's potential therapeutic effects is offered.

  4. A Spanish ''Power Tower'' solar system: Project CESA-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Torralbo, A.M.; Gonzalvez, M.; Lacal, J.A.

    1984-02-01

    Like many other countries and organizations, Spain has been developing a program to investigate the economic viability of new sources of energy. Among these, it should be pointed out, is included the large solar power systems. Within this investigation program, ''Centro de Estudios de la Energia'', an organization dependent on ''Ministerio de Industria y Energia'', is carrying out the CESA-1 Project, which consists of design, construction, start-up, and operation of a 1.2-MW Pilot Solar Power Plant. If the current technical uncertainties are removed and the power tower concept demonstrates its economical viability, Spain will be one of the most appropriatemore » countries in the world for a full-scale implementation of this technology. For this reason, the ''Ministerio de Industria y Energia'' reached the conclusion in mid-1977 that it would be of interest to explore this technology using the domestic industrial potential. The project was approved by the Council of Ministers in June 1977 and the project begun in early 1978. The management of the Project is the direct responsibility of ''El Centro de Estudios de la Energia'' and was helped by the engineering firms Initec and Sener to attain the adequate organization to carry out the project.« less

  5. On the Role of Mentalizing Processes in Aesthetic Appreciation: An ERP Study

    PubMed Central

    Beudt, Susan; Jacobsen, Thomas

    2015-01-01

    We used event-related brain potentials to explore the impact of mental perspective taking on processes of aesthetic appreciation of visual art. Participants (non-experts) were first presented with information about the life and attitudes of a fictitious artist. Subsequently, they were cued trial-wise to make an aesthetic judgment regarding an image depicting a piece of abstract art either from their own perspective or from the imagined perspective of the fictitious artist [i.e., theory of mind (ToM) condition]. Positive self-referential judgments were made more quickly and negative self-referential judgments were made more slowly than the corresponding judgments from the imagined perspective. Event-related potential analyses revealed significant differences between the two tasks both within the preparation period (i.e., during the cue-stimulus interval) and within the stimulus presentation period. For the ToM condition we observed a relative centro-parietal negativity during the preparation period (700–330 ms preceding picture onset) and a relative centro-parietal positivity during the stimulus presentation period (700–1100 ms after stimulus onset). These findings suggest that different subprocesses are involved in aesthetic appreciation and judgment of visual abstract art from one’s own vs. from another person’s perspective. PMID:26617506

  6. Activities of the International Radio Medical Centre (C.I.R.M.) in Rome during the last five years (1996-2000). Centro Internazionale Radio Medico.

    PubMed

    Amenta, F; Dauri, A

    2001-01-01

    This paper reviews medical activity provided from 1996 to 2000 by the International Radio Medical Centre (Centro Internazionale Radio Medico, C.I.R.M.). C.I.R.M. is a non-profit organization headquartered in Rome and providing freely telemedical advice to ships flying of any flag navigating on all seas of the world, to civil airplanes and to small Italian islands. From 1996 to 2000 C.I.R.M. has assisted 4,982 patients, 4,686 of which (94%) on board ships, 85 on airplanes and 206 on small Italian islands. More than 65% of requests of telemedical advice received by C.I.R.M. were from non-Italian ships. This indicates the really international nature of C.I.R.M.'s activity. The largest number of medical requests come from the Atlantic Ocean, followed by the Mediterranean sea, Indian Ocean and Pacific Ocean. In terms of pathologies assisted, accidents took the first place, followed as main pathologies by gastrointestinal disorders, cardiovascular pathologies, respiratory disorders, infectious and parasitic diseases and nervous system complaints. Analysis of the outcome of C.I.R.M.'s medical activity showed that more than 50% of patients assisted were recovered or improved while assisted by the Centre.

  7. Two spinning ways for precession dynamo.

    PubMed

    Cappanera, L; Guermond, J-L; Léorat, J; Nore, C

    2016-04-01

    It is numerically demonstrated by means of a magnetohydrodynamic code that precession can trigger dynamo action in a cylindrical container. Fixing the angle between the spin and the precession axis to be 1/2π, two limit configurations of the spinning axis are explored: either the symmetry axis of the cylinder is parallel to the spin axis (this configuration is henceforth referred to as the axial spin case), or it is perpendicular to the spin axis (this configuration is referred to as the equatorial spin case). In both cases, the centro-symmetry of the flow breaks when the kinetic Reynolds number increases. Equatorial spinning is found to be more efficient in breaking the centro-symmetry of the flow. In both cases, the average flow in the reference frame of the mantle converges to a counter-rotation with respect to the spin axis as the Reynolds number grows. We find a scaling law for the average kinetic energy in term of the Reynolds number in the axial spin case. In the equatorial spin case, the unsteady asymmetric flow is shown to be capable of sustaining dynamo action in the linear and nonlinear regimes. The magnetic field is mainly dipolar in the equatorial spin case, while it is is mainly quadrupolar in the axial spin case.

  8. Mk x Nk gated CMOS imager

    NASA Astrophysics Data System (ADS)

    Janesick, James; Elliott, Tom; Andrews, James; Tower, John; Bell, Perry; Teruya, Alan; Kimbrough, Joe; Bishop, Jeanne

    2014-09-01

    Our paper will describe a recently designed Mk x Nk x 10 um pixel CMOS gated imager intended to be first employed at the LLNL National Ignition Facility (NIF). Fabrication involves stitching MxN 1024x1024x10 um pixel blocks together into a monolithic imager (where M = 1, 2, . .10 and N = 1, 2, . . 10). The imager has been designed for either NMOS or PMOS pixel fabrication using a base 0.18 um/3.3V CMOS process. Details behind the design are discussed with emphasis on a custom global reset feature which erases the imager of unwanted charge in ~1 us during the fusion ignition process followed by an exposure to obtain useful data. Performance data generated by prototype imagers designed similar to the Mk x Nk sensor is presented.

  9. Inference of viscosity jump at 670 km depth and lower mantle viscosity structure from GIA observations

    NASA Astrophysics Data System (ADS)

    Nakada, Masao; Okuno, Jun'ichi; Irie, Yoshiya

    2018-03-01

    A viscosity model with an exponential profile described by temperature (T) and pressure (P) distributions and constant activation energy (E_{{{um}}}^{{*}} for the upper mantle and E_{{{lm}}}^* for the lower mantle) and volume (V_{{{um}}}^{{*}} and V_{{{lm}}}^*) is employed in inferring the viscosity structure of the Earth's mantle from observations of glacial isostatic adjustment (GIA). We first construct standard viscosity models with an average upper-mantle viscosity ({\\bar{η }_{{{um}}}}) of 2 × 1020 Pa s, a typical value for the oceanic upper-mantle viscosity, satisfying the observationally derived three GIA-related observables, GIA-induced rate of change of the degree-two zonal harmonic of the geopotential, {\\dot{J}_2}, and differential relative sea level (RSL) changes for the Last Glacial Maximum sea levels at Barbados and Bonaparte Gulf in Australia and for RSL changes at 6 kyr BP for Karumba and Halifax Bay in Australia. Standard viscosity models inferred from three GIA-related observables are characterized by a viscosity of ˜1023 Pa s in the deep mantle for an assumed viscosity at 670 km depth, ηlm(670), of (1 - 50) × 1021 Pa s. Postglacial RSL changes at Southport, Bermuda and Everglades in the intermediate region of the North American ice sheet, largely dependent on its gross melting history, have a crucial potential for inference of a viscosity jump at 670 km depth. The analyses of these RSL changes based on the viscosity models with {\\bar{η }_{{{um}}}} ≥ 2 × 1020 Pa s and lower-mantle viscosity structures for the standard models yield permissible {\\bar{η }_{{{um}}}} and ηlm (670) values, although there is a trade-off between the viscosity and ice history models. Our preferred {\\bar{η }_{{{um}}}} and ηlm (670) values are ˜(7 - 9) × 1020 and ˜1022 Pa s, respectively, and the {\\bar{η }_{{{um}}}} is higher than that for the typical value of oceanic upper mantle, which may reflect a moderate laterally heterogeneous upper-mantle viscosity. The mantle viscosity structure adopted in this study depends on temperature distribution and activation energy and volume, and it is difficult to discuss the impact of each quantity on the inferred lower-mantle viscosity model. We conclude that models of smooth depth variation in the lower-mantle viscosity following η ( z ) ∝ {{ exp}}[ {( {E_{{{lm}}}^* + P( z )V_{{{lm}}}^*} )/{{R}}T( z )} ] with constant E_{{{lm}}}^* and V_{{{lm}}}^* are consistent with the GIA observations.

  10. VizieR Online Data Catalog: MHOs toward 22 regions with H2 fluxes (Wolf-Chase+, 2017)

    NASA Astrophysics Data System (ADS)

    Wolf-Chase, G.; Arvidsson, K.; Smutko, M.

    2018-03-01

    We obtained H2 2.12um, H2 2.25um, and H2 continuum) images of 26 regions thought to contain massive YSOs, using the Near-infrared Camera and Fabry-Perot Spectrometer (NICFPS) on the Astrophysical Research Consortium (ARC) 3.5m telescope at the Apache Point Observatory (APO) in Sunspot, NM. (3 data files).

  11. Implementação de um algoritmo para a limpeza de mapas da RCFM

    NASA Astrophysics Data System (ADS)

    Souza, C. L.; Wuensche, C. A.

    2003-08-01

    A Radiação Cósmica de Fundo em Microondas (RCFM), descoberta por Penzias e Wilson em 1965, é uma das ferramentas mais poderosas para o estudo da cosmologia. Com a descoberta de flutuações de temperatura na RCFM, da ordem de uma parte em 105, pelo COBE (1992), uma nova era teve início. Nos últimos onze anos, diversos instrumentos fizeram novas medidas de alta precisão, refinando os resultados apresentados pelo COBE, culminando com os resultados recentes do satélite WMAP. A análise de dados da RCFM, especialmente no caso de experimentos com pequena cobertura do céu, apresenta uma série de dificuldades devido a emissões de contaminantes externos, tais como a emissão da Galáxia e de fontes pontuais, e de ruídos intrínsecos tanto ao sistema de detecção quanto à estratégia de observação do céu. Uma das soluções típicas para a filtragem de dados brutos de um experimento para medir flutuações de temperatura é aplicar um gabarito (template) e um filtro passa alta ao produzir mapas simplificados (sem considerar matrizes de correlação ou covariância). No caso de experimentos que utilizam detectores HEMT, essa combinação de filtros remove, satisfatoriamente, ruídos do tipo 1/f gerados pela instabilidade no ganho do detector acoplado ao movimento do instrumento, definido pela estratégia de observação. Entretanto, o sinal resultante medido, tanto em simulações quanto em séries temporais reais, sugere que parte do sinal cosmológico pode estar sendo removido junto com o ruído dos detectores. Este trabalho descreve as etapas para a produção de um mapa típico (simulado) e os testes preliminares de um algoritmo para remover ruídos do tipo 1/f introduzidos pela estratégia de observação sem prejudicar a qualidade do sinal cosmológico presente no mapa.

  12. Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lynch, Caitlin; Pan, Yongmei; Li, Linhao

    Objective: Accumulating evidence suggests that activation of mouse constitutive androstane receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic gluconeogenesis, lipogenesis, and fatty acid synthesis. However, the role of human (h) CAR in energy metabolism is largely unknown. The present study aims to investigate the effects of selective hCAR activators on hepatic energy metabolism in human primary hepatocytes (HPH). Methods: Ligand-based structure–activity models were used for virtual screening of the Specs database ( (www.specs.net)) followed by biological validation in cell-based luciferase assays. The effects of two novel hCAR activators (UM104 and UM145) on hepatic energy metabolism were evaluatedmore » in HPH. Results: Real-time PCR and Western blotting analyses reveal that activation of hCAR by UM104 and UM145 significantly repressed the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, two pivotal gluconeogenic enzymes, while exerting negligible effects on the expression of genes associated with lipogenesis and fatty acid synthesis. Functional experiments show that UM104 and UM145 markedly inhibit hepatic synthesis of glucose but not triglycerides in HPH. In contrast, activation of mCAR by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a selective mCAR activator, repressed the expression of genes associated with gluconeogenesis, lipogenesis, and fatty acid synthesis in mouse primary hepatocytes, which were consistent with previous observations in mouse model in vivo. Conclusion: Our findings uncover an important species difference between hCAR and mCAR in hepatic energy metabolism, where hCAR selectively inhibits gluconeogenesis without suppressing fatty acid synthesis. Implications: Such species selectivity should be considered when exploring CAR as a potential therapeutic target for metabolic disorders. - Highlights: • Novel hCAR activators were identified by computational and biological approaches. • The role of hCAR in hepatic energy metabolism was examined. • hCAR activators repress gluconeogenesis but not lipogenesis and fatty acid synthesis. • Human and mouse CAR exhibit differential effects on energy metabolism.« less

  13. III-V strain layer superlattice based band engineered avalanche photodiodes (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Ghosh, Sid

    2015-08-01

    Laser detection and ranging (LADAR)-based systems operating in the Near Infrared (NIR) and Short Wave Infrared (SWIR) have become popular optical sensors for remote sensing, medical, and environmental applications. Sophisticated laser-based radar and weapon systems used for long-range military and astronomical applications need to detect, recognize, and track a variety of targets under a wide spectrum of atmospheric conditions. Infrared APDs play an important role in LADAR systems by integrating the detection and gain stages in a single device. Robust silicon-APDs are limited to visible and very near infrared region (< 1 um), while InGaAs works well up to wavelengths of about 1.5um. Si APDs have low multiplication or excess noise but are limited to below 1um due very poor quantum efficiency above 0.8um. InGaAs and Ge APDs operate up to wavelengths of 1.5um but have poor multiplication or excess noise due to a low impact ionization coefficient ratio between electrons and holes. For the past several decades HgCdTe has been traditionally used in longer wavelength (> 3um) infrared photon detection applications. Recently, various research groups (including Ghosh et. al.) have reported SWIR and MWIR HgCdTe APDs on CdZnTe and Si substrates. However, HgCdTe APDs suffer from low breakdown fields due to material defects, and excess noise increases significantly at high electric fields. During the past decade, InAs/GaSb Strain Layer Superlattice (SLS) material system has emerged as a potential material for the entire infrared spectrum because of relatively easier growth, comparable absorption coefficients, lower tunneling currents and longer Auger lifetimes resulting in enhanced detectivities (D*). Band engineering in type II SLS allows us to engineer avalanche properties of electrons and holes. This is a great advantage over bulk InGaAs and HgCdTe APDs where engineering avalanche properties is not possible. The talk will discuss the evolution of superlattice based avalanche photodiodes and some of the recent results on the work being done at Raytheon on SWIR avalanche photodiodes.

  14. Identificabilidade e estabilidade dos parâmetros no método Grade of Membership (GoM): considerações metodológicas e práticas

    PubMed Central

    Guedes, Gilvan Ramalho; Caetano, André Junqueira; Machado, Carla Jorge; Brondízio, Eduardo Sonewend

    2011-01-01

    O método Grade of Membership (GoM) tem sido cada vez mais utilizado por demógrafos brasileiros e tem a vantagem de possuir um parâmetro que mensura a heterogeneidade individual, com base nas correlações não-observáveis entre as categorias de resposta das variáveis de interesse, gerando um medida do grau de pertencimento de cada indivíduo a perfis extremos. Alguns autores, contudo, chamam atenção para questões importantes na calibragem dos modelos finais que utilizam o programa GoM versão 3.4, como o problema de identificabilidade – soluções múltiplas para parâmetros estimados. Neste artigo, é sugerido um procedimento capaz de identificar um modelo final com solução única que descreva os tipos puros mais fidedignos à base de dados, em uma tentativa de otimização. Para ilustrar esse processo, utilizou-se uma base de dados correspondente a um levantamento econômico e sociodemográfico de uma população de pequenos agricultores residentes ao longo da Rodovia Transamazônica, no Estado do Pará. Também identificou-se a existência de instabilidade nos parâmetros estimados pelo programa GoM 3.4, sendo proposto um método de estabilização de seus valores. Com esses procedimentos combinados, os usuários do programa GoM 3.4 poderão descrever sua base de dados de forma mais adequada e responder às críticas sobre questões de identificabilidade e estabilidade dos modelos resultantes. Essas soluções empíricas são relevantes por afetarem cálculos de prevalência e de incidência de eventos de interesse, além de trazerem consequências importantes sobre o ponto e o momento corretos para intervenções de políticas públicas ou de planejamento prospectivo em análises de projeção. PMID:21709732

  15. Herschel Galactic plane survey of ionized gas traced by [NII

    NASA Astrophysics Data System (ADS)

    Yildiz, Umut; Goldsmith, Paul; Pineda, Jorge; Langer, William

    2015-01-01

    Far infrared and sub-/millimeter atomic & ionic fine structure and molecular rotational lines are powerful tracers of star formation on both Galactic and extragalactic scales. Although CO lines trace cool to moderately warm molecular gas, ionized carbon [CII] produces the strongest lines, which arise from almost all reasonably warm (T>50 K) parts of the ISM. However, [CII] alone cannot distinguish highly ionized gas from weakly ionized gas. [NII] plays a significant role in star formation as it is produced only in ionized regions; in [HII] regions as well as diffuse ionized gas. The ionization potential of nitrogen (14.5 eV) is greater than that of hydrogen (13.6 eV), therefore the ionized nitrogen [NII] lines reflect the effects of massive stars, with possible enhancement from X-ray and shock heating from the surroundings. Two far-infrared 122 um and 205 um [NII] fine structure spectral lines are targeted via Photodetector Array Camera and Spectrometer (PACS) onboard Herschel Space Observatory. The sample consists of 149 line-of-sight (LOS) positions in the Galactic plane. These positions overlap with the [CII] 158 um observations obtained with the GOT C+ survey. With a reasonable assumption that the emission from both 122 um and 205 um lines originate in the same gas; [NII] 122/205 um line ratio indicates the a good measure of the electron density of each of the LOS positions. [NII] detections are mainly toward the Galactic center direction and the [NII] electron densities are found between 7-50 cm^-3, which is enhanced WIM (Warm Ionized Medium). WIM densities are expected to be much lower (~1 cm-3), therefore non-detections toward the opposite side of the Galactic Center shows abundant of this gas. The pixel to pixel variation of the emission within a single Herschel pointing is relatively small, which is interpreted as the [NII] emission comes from an extended gas. It is important to quantify what fraction of [CII] emission arises in the ionized gas. Thus, with the present work of [NII] observations, it will be possible to resolve the different parts of the ISM leading to determine the total mass of the ISM.

  16. Provenance and metamorphic PT conditions of Cryogenian-Ediacaran metasediments from the Kid metamorphic complex, Sinai, NE Arabian-Nubian Shield: Insights from detrital zircon geochemistry and mineral chemistry

    NASA Astrophysics Data System (ADS)

    El-Bialy, Mohammed Z.; Ali, Kamal A.; Abu El-Enen, Mahrous M.; Ahmed, Ahmed H.

    2015-12-01

    The Malhaq and Um Zariq formations occupy the northern part of the Neoproterozoic Kid metamorphic complex of SE Sinai, NE Arabian-Nubian Shield. This study presents new mineral chemistry data and LA-ICP-MS analyses of the trace element concentrations on zircons separated from metapelites from these formations. The detrital zircons of Um Zariq Formation are more enriched in ΣREE, whereas Malhaq Formation zircons are markedly HREE-enriched with strongly fractionated HREE patterns. The quite differences in the overall slope and size of the Eu and Ce anomalies between REE patterns of the two zircon suites provide a robust indication of different sources. The Ti-in-zircon thermometer has revealed that the zircons separated from Malhaq Formation were crystallized within the 916-1018 °C range, while those from Um Zariq Formation exhibit higher range of crystallization temperatures (1084-1154 °C). The detrital zircons of Malhaq Formation were derived mainly from mafic source rocks (basalt and dolerite), whereas Um Zariq Formation zircons have varied and more evolved parent rocks. Most of the investigated zircons from both formations are concluded to be unaltered magmatic that were lately crystallized from a high LREE/HREE melt. All the studied detrital zircon grains show typical trace elements features of crustal-derived zircons. All of the Um Zariq Formation and most of Malhaq Formation detrital zircons are geochemically discriminated as continental zircons. Both formation metapelites record similar, overlapping peak metamorphic temperatures (537-602 °C and 550-579 °C, respectively), and pressures (3.83-4.93 kbar and 3.69-4.07 kbar, respectively). The geothermal gradient, at the peak metamorphic conditions, was quite high (37-41 °C/km) corresponding to metamorphism at burial depth of 14-16 km. The peak regional metamorphism of Um Zariq and Malhaq formations is concluded to be generated during extensional regime and thinning of the lithosphere in an island arc setting with heat flow from the underlying arc granitoids.

  17. Detection of horse allergen around a stable.

    PubMed

    Elfman, Lena; Brannstrom, Johan; Smedje, Greta

    2008-01-01

    Integrating horse stables with built-up areas may lead to conflicts. Dispersion of horse allergen may become a health risk for allergic people. The aim was to measure the dispersion of horse allergen around a stable, considering wind speed and direction and vegetation. The disturbance of staff at a workplace nearby a stable was investigated. Air sampling was performed around a stable (32 horses) at distances of 50-500 m in all directions. Sampling was done with a pump and an IOM sampler. Samples were collected at 50 points during all seasons. Horse allergen levels were determined using ELISA. Disturbance by horses was studied with a questionnaire handed to the employees in an office near the stable. The median horse allergen level at the stable entrance was 316 U/m(3), in the horse fields 40 U/m(3) and in the whole source area 16 U/m(3), which declined to <2 U/m(3) at about 50 m from the source area. Downwind of the prevailing winds low levels of horse allergen (2-4 U/m(3)) could sometimes be detected at up to 500 m. The staff, including those allergic to horses, managed to tolerate horses close to the workplace. At low winds horse allergen spread in ambient air about 50 m from the stable and horse fields. At higher winds low allergen levels were sometimes found in open areas up to 500 m from the source area. These levels were similar to those found in the office after moving away from the stable area. The employees did not report more symptoms of allergy or asthma while working close to the stable compared to after the move. 2007 S. Karger AG, Basel

  18. Health Risk Assessment of Lead Ingestion Exposure by Particle Sizes in Crumb Rubber on Artificial Turf Considering Bioavailability

    PubMed Central

    Kim, Sunduk; Yang, Ji-Yeon; Kim, Ho-Hyun; Yeo, In-Young; Shin, Dong-Chun

    2012-01-01

    Objectives The purpose of this study was to assess the risk of ingestion exposure of lead by particle sizes of crumb rubber in artificial turf filling material with consideration of bioavailability. Methods This study estimated the ingestion exposure by particle sizes (more than 250 um or less than 250 um) focusing on recyclable ethylene propylene diene monomer crumb rubber being used as artificial turf filling. Analysis on crumb rubber was conducted using body ingestion exposure estimate method in which total content test method, acid extraction method and digestion extraction method are reflected. Bioavailability which is a calibrating factor was reflected in ingestion exposure estimate method and applied in exposure assessment and risk assessment. Two methods using acid extraction and digestion extraction concentration were compared and evaluated. Results As a result of the ingestion exposure of crumb rubber material, the average lead exposure amount to the digestion extraction result among crumb rubber was calculated to be 1.56×10-4 mg/kg-day for low grade elementary school students and 4.87×10-5 mg/kg-day for middle and high school students in 250 um or less particle size, and that to the acid extraction result was higher than the digestion extraction result. Results of digestion extraction and acid extraction showed that the hazard quotient was estimated by about over 2 times more in particle size of lower than 250 um than in higher than 250 um. There was a case of an elementary school student in which the hazard quotient exceeded 0.1. Conclusions Results of this study confirm that the exposure of lead ingestion and risk level increases as the particle size of crumb rubber gets smaller. PMID:22355803

  19. An observational study of Venlafaxine and CYP2D6 in clinical practice.

    PubMed

    Rolla, R; Gramaglia, Carla; Dalò, Valentina; Ressico, Francesca; Prosperini, Pierluigi; Vidali, Matteo; Meola, Silvia; Pollarolo, Paola; Bellomo, Giorgio; Torre, Eugenio; Zeppegno, Patrizia

    2014-01-01

    Venlafaxine (V) is a serotonin-norepinephrine selective reuptake inhibitor, mainly metabolized by cytochrome P4502D6 (CYP2D6). CYP2D6 polymorphisms result in a variety of phenotypes: poor (PMs), intermediate (IMs), extensive (EMs), and ultrarapid metabolizers (UMs). PMs usually show poor tolerance to drugs metabolized by CYP2D6, while UMs need greater doses. The aim of this study was to evaluate the impact of CYP2D6 genotype on V dosage, therapeutic response, and side effects in a clinical outpatient setting. 47 patients with Major Depressive Disorder, treated with V 75 - 300 mg/day, underwent CYP2D6 genotyping using the INFINITI-CYP2D6 assay. Duration of treatment and clinical outcome (Clinical Global Impression [CGI] effectiveness index) were assessed. CGI assessment was performed after 6 weeks, 6 months, and 1 year of treatment with a V median dose of 150 mg/day. CYP2D6 genotyping resulted in 1 PM, 3 IMs, 42 EMs, and 1 UM. The UM took the greatest V dose (375 mg) without side effects; IMs/PMs took moderate/high doses of V (150 - 300 mg) without adverse effects; EMs displayed high response variability. PM/IM patients responded to V differently than expected according to genotype. However, the UM patient responded to a dosage higher than the usual therapeutic range and without developing side effects, suggesting an association between CYP2D6 gene duplication and the therapeutic efficacy of venlafaxine. The CYP2D6 genotyping may thus provide clinicians with a potential explanation for those patients requiring greater doses of CYP2D6 substrates in order to obtain the same therapeutic efficacy.

  20. The resolution sensitivity of the Asian summer monsoon and its inter-model comparison between MRI-AGCM and MetUM

    NASA Astrophysics Data System (ADS)

    Ogata, Tomomichi; Johnson, Stephanie J.; Schiemann, Reinhard; Demory, Marie-Estelle; Mizuta, Ryo; Yoshida, Kohei; Osamu Arakawa

    2017-11-01

    In this study, we compare the resolution sensitivity of the Asian Summer Monsoon (ASM) in two Atmospheric General Circulation Models (AGCMs): the MRI-AGCM and the MetUM. We analyze the MetUM at three different resolutions, N96 (approximately 200-km mesh on the equator), N216 (90-km mesh) and N512 (40-km mesh), and the MRI-AGCM at TL95 (approximately 180-km mesh on the equator), TL319 (60-km mesh), and TL959 (20-km mesh). The MRI-AGCM and the MetUM both show decreasing precipitation over the western Pacific with increasing resolution, but their precipitation responses differ over the Indian Ocean. In MRI-AGCM, a large precipitation increase appears off the equator (5-20°N). In MetUM, this off-equatorial precipitation increase is less significant and precipitation decreases over the equator. Moisture budget analysis demonstrates that a changing in moisture flux convergence at higher resolution is related to the precipitation response. Orographic effects, intra-seasonal variability and the representation of the meridional thermal gradient are explored as possible causes of the resolution sensitivity. Both high-resolution AGCMs (TL959 and N512) can represent steep topography, which anchors the rainfall pattern over south Asia and the Maritime Continent. In MRI-AGCM, representation of low pressure systems in TL959 also contributes to the rainfall pattern. Furthermore, the seasonal evolution of the meridional thermal gradient appears to be more accurate at higher resolution, particularly in the MRI-AGCM. These findings emphasize that the impact of resolution is only robust across the two AGCMs for some features of the ASM, and highlights the importance of multi-model studies of GCM resolution sensitivity.

  1. Quantification of Changes in Oxygen Release from Red Blood Cells as a Function of Age Based on Magnetic Susceptibility Measurements

    PubMed Central

    Jin, Xiaoxia; Yazer, Mark H.; Chalmers, Jeffrey J.; Zborowski, Maciej

    2013-01-01

    This study extends the in vitro understanding of the RBC storage lesion by serially analyzing the RBC’s magneophoretic mobility, a property dependent on the content and oxygenation or oxidation state of hemoglobin (Hb) iron, during storage. Four prestorage leukoreduced, AS-5 preserved RBC units were stored between 1–6°C for 42 days. Weekly starting on storage day 7, each unit was sampled, the aliquot divided into 3 portions and subjected to different reactions: one portion was exposed to room air to produce oxyhemoglobin (oxyHb), another portion was mixed with sodium nitrite to produce methemoglobin (metHb), while the third portion was desaturated of oxygen (deoxyhemoglobin, deoxyHb) using nitrogen gas. These portions were placed into a cell tracking velocimetry (CTV) apparatus which measured both the settling velocity (us) of the RBCs as well as their magnetically induced velocity (um). The um/us ratio depends on the oxygenation or oxidation state and quantity of iron within the RBC. RBC density was measured by percoll centrifugation. There was a significant reduction in the um/us ratio for the deoxyHb RBC portion as storage time elapsed, with a smaller but still significant reduction in the um/us ratio for the metHb portion. The average RBC density decreased very slightly during storage, as determined by percoll centrifugation technique, although the average settling velocity (another measure of cell density) seemed to fluctuate during storage. The decrease in magnetophoretic mobility of the deoxyHb portion, presented as the ratio of um/us, is explicable either by Hb’s increased affinity for oxygen during storage, or a loss of iron from the cells. PMID:21647486

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soileau, S.D.

    Chlordecone (CHLO, 1-30 uM) and chlordecone alcohol (CHLO ALC, 1-23 uM) altered the permeability of isolated ovine erythrocytes (OE) as evidenced by a concentration- and time-dependent induction of K/sup +/ efflux and hemolysis. Hemolysis, but no K/sup +/ efflux, was markedly delayed when OE were suspended in isotonic sucrose. Low concentrations of both compounds (1-4 uM) protected OE against hypotonic hemolysis. Neither CHLO (30 uM) nor CHLO ALC (23 uM) induced the release of trapped K/sup +/ from KSCN-loaded, OE-lipid, unilamellar liposomes. CHLO- and CHLO ACL-induced hemolysis and K/sup +/ efflux were dependent upon the pH of the external media.more » CHLO ALC-induced K/sup +/ efflux and hemolysis showed a slight pH dependence, with increased potency of the compound detected over the pH range 8.3-9.4 CHLO ALC-induced protection against hypotonic hemolysis was pH independent. The potency of CHLO in all three assays decreased as the pH was raised from 6.4 to 9.4. (/sup 14/C)-CHLO and (/sup 14/C)-CHLO ALC binding to OE and OE membranes was pH independent. However, the binding of (/sup 14/C)-CHLO to polypropylene and glass was pH dependent. (/sup 14/C)-CHLO binding to polypropylene and glass decreased from pH 6.4 to pH 10.4. The pKa of CHLO was estimated to be 8.9. After the CHLO results were corrected for the fraction of CHLO present in the unionized form, it was estimated the ionized CHLO possessed 1/3 to 1/20 of the activity of the unionized species.« less

  3. Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer

    PubMed Central

    Forsberg, Lars A.; Rasi, Chiara; Pekar, Gyula; Davies, Hanna; Piotrowski, Arkadiusz; Absher, Devin; Razzaghian, Hamid Reza; Ambicka, Aleksandra; Halaszka, Krzysztof; Przewoźnik, Marcin; Kruczak, Anna; Mandava, Geeta; Pasupulati, Saichand; Hacker, Julia; Prakash, K. Reddy; Dasari, Ravi Chandra; Lau, Joey; Penagos-Tafurt, Nelly; Olofsson, Helena M.; Hallberg, Gunilla; Skotnicki, Piotr; Mituś, Jerzy; Skokowski, Jaroslaw; Jankowski, Michal; Śrutek, Ewa; Zegarski, Wojciech; Tiensuu Janson, Eva; Ryś, Janusz; Tot, Tibor; Dumanski, Jan P.

    2015-01-01

    Sporadic breast cancer (SBC) is a common disease without robust means of early risk prediction in the population. We studied 282 females with SBC, focusing on copy number aberrations in cancer-free breast tissue (uninvolved margin, UM) outside the primary tumor (PT). In total, 1162 UMs (1–14 per breast) were studied. Comparative analysis between UM(s), PT(s), and blood/skin from the same patient as a control is the core of the study design. We identified 108 patients with at least one aberrant UM, representing 38.3% of cases. Gains in gene copy number were the principal type of mutations in microscopically normal breast cells, suggesting that oncogenic activation of genes via increased gene copy number is a predominant mechanism for initiation of SBC pathogenesis. The gain of ERBB2, with overexpression of HER2 protein, was the most common aberration in normal cells. Five additional growth factor receptor genes (EGFR, FGFR1, IGF1R, LIFR, and NGFR) also showed recurrent gains, and these were occasionally present in combination with the gain of ERBB2. All the aberrations found in the normal breast cells were previously described in cancer literature, suggesting their causative, driving role in pathogenesis of SBC. We demonstrate that analysis of normal cells from cancer patients leads to identification of signatures that may increase risk of SBC and our results could influence the choice of surgical intervention to remove all predisposing cells. Early detection of copy number gains suggesting a predisposition toward cancer development, long before detectable tumors are formed, is a key to the anticipated shift into a preventive paradigm of personalized medicine for breast cancer. PMID:26430163

  4. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.

    PubMed

    Carlson, Bradley A; Xu, Xue-Ming; Gladyshev, Vadim N; Hatfield, Dolph L

    2005-02-18

    Selenocysteine (Sec) is the 21st amino acid in the genetic code. Its tRNA is variably methylated on the 2'-O-hydroxyl site of the ribosyl moiety at position 34 (Um34). Herein, we identified a role of Um34 in regulating the expression of some, but not all, selenoproteins. A strain of knock-out transgenic mice was generated, wherein the Sec tRNA gene was replaced with either wild type or mutant Sec tRNA transgenes. The mutant transgene yielded a tRNA that lacked two base modifications, N(6)-isopentenyladenosine at position 37 (i(6)A37) and Um34. Several selenoproteins, including glutathione peroxidases 1 and 3, SelR, and SelT, were not detected in mice rescued with the mutant transgene, whereas other selenoproteins, including thioredoxin reductases 1 and 3 and glutathione peroxidase 4, were expressed in normal or reduced levels. Northern blot analysis suggested that other selenoproteins (e.g. SelW) were also poorly expressed. This novel regulation of protein expression occurred at the level of translation and manifested a tissue-specific pattern. The available data suggest that the Um34 modification has greater influence than the i(6)A37 modification in regulating the expression of various mammalian selenoproteins and Um34 is required for synthesis of several members of this protein class. Many proteins that were poorly rescued appear to be involved in responses to stress, and their expression is also highly dependent on selenium in the diet. Furthermore, their mRNA levels are regulated by selenium and are subject to nonsense-mediated decay. Overall, this study described a novel mechanism of regulation of protein expression by tRNA modification that is in turn regulated by levels of the trace element, selenium.

  5. In-vitro ablation of fibrocartilage by XeCl excimer laser

    NASA Astrophysics Data System (ADS)

    Buchelt, Martin; Papaioannou, Thanassis; Fishbein, Michael C.; Peters, Werner; Beeder, Clain; Grundfest, Warren S.

    1991-07-01

    A 308 nm excimer laser was employed for ablation of human fibrocartilage. Experiments were conducted in vitro. The tissue response was investigated with respect to dosimetry (ablation rate versus radiant exposure) and thermal effect (thermographic analysis). Irradiation was performed via a 600 um fiber, with radiant exposures ranging between 20mj/mm2 and 80mj/mm2, at 20Hz. The ablation rates were found to range from 3um/pulse to 80um/pulse depending on the radiant exposure and/or the applied pressure on the delivery system. Thermographic analysis, during ablation, revealed maximum average temperatures of about 65 degree(s)C. Similar measurements performed, for the purpose of comparison, with a CW Nd:YAG and a CW CO2 laser showed higher values, of the order of 200 degree(s)C.

  6. Investigation of Electron Transfer-Based Photonic and Electro-Optic Materials and Devices

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bromenshenk, Jerry J; Abbott, Edwin H; Dickensheets, David

    2008-03-28

    Montana's state program began its sixth year in 2006. The project's research cluster focused on physical, chemical, and biological materials that exhibit unique electron-transfer properties. Our investigators have filed several patents and have also have established five spin-off businesses (3 MSU, 2 UM) and a research center (MT Tech). In addition, this project involved faculty and students at three campuses (MSU, UM, MT Tech) and has a number of under-represented students, including 10 women and 5 Native Americans. In 2006, there was an added emphasis on exporting seminars and speakers via the Internet from UM to Chief Dull Knife Communitymore » College, as well as work with the MT Department of Commerce to better educate our faculty regarding establishing small businesses, licensing and patent issues, and SBIR program opportunities.« less

  7. Building the Rule of Law: U.S. Assistance Programs and Police/Military Relations in Latin America

    DTIC Science & Technology

    2003-02-01

    which toppled a military-backed conservative government), Colombia’s decade-long “La Violencia ” in the 1950’s (the police generally supported the...Centro de Estudios Legales y Sociales (CELS) and Human Rights Watch/Americas. La Inseguridad Policial: Violencia de las Fuerzas de Seguridad en la...et al. Narcotrafico en Colombia: Dimensiones Politicas , Economicas, Juridicas e Internacionales (Bogota: Tercero Mundo Editores, 1991). Bagley

  8. State-Building Challenges in a Post-Revolution Libya

    DTIC Science & Technology

    2012-10-01

    for the Army, the Department of De - fense, and the larger national security community. In addition to its studies, SSI publishes special reports on...addition, his publications include com- mentaries and research papers for the Centro de Es- tudios y Documentacion Internacionales de Barcelona (CIDOB...and the Centre d’Études Internationales de Rabat, as well as various newspaper articles in and about the region. He is a frequent commentator in the

  9. Use of 70 MeV Proton Beam for Medical Applications at INFN-LNS: CATANA Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sabini, M.G.; Cirrone, G.A.P.; Barone Tonghi, L.

    The project CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) is a collaboration between the INFN-Laboratori Nazionali del Sud (LNS), Physics Department, Ophthalmology Institute and Radiology Institute of the Catania University and CSFNSM Catania. The main goal of CATANA is the study and the application of proton therapy for the treatment of shallow tumors (4 cm max) like uveal melanomas and subfoveal macular degenerations.

  10. Use of 70 MeV proton beam for medical applications at INFN-LNS: CATANA project

    NASA Astrophysics Data System (ADS)

    Sabini, M. G.; Cirrone, G. A. P.; Tonghi, L. Barone; Bartolotta, A.; Brai, M.; Cuttone, G.; Nigro, S. Lo; Marano, F.; Nicoletti, G. A.; Privitera, G.; Raffaele, L.; Reibaldi, A.; Romeo, N.; Rovelli, A.; Salamone, V.; Teri, G.

    2000-04-01

    The project CATANA (Centro di Adro Terapia ed Applicazioni Nucleari Avanzate) is a collaboration between the INFN-Laboratori Nazionali del Sud (LNS), Physics Department, Ophthalmology Institute and Radiology Institute of the Catania University and CSFNSM Catania. The main goal of CATANA is the study and the application of protontherapy for the treatment of shallow tumors (4 cm max) like uveal melanomas and subfoveal macular degenerations.

  11. Tunable microlens arrays using polymer network liquid crystal

    NASA Astrophysics Data System (ADS)

    Ren, Hongwen; Fan, Yun-Hsing; Gauza, Sebastian; Wu, Shin-Tson

    2004-02-01

    A tunable-focus microlens array based on polymer network liquid crystal (PNLC) is demonstrated. The PNLC was prepared using an ultraviolet (UV) light exposure through a patterned photomask. The photocurable monomer in each of the UV exposed spot forms an inhomogeneous centro-symmetrical polymer network which acts as a lens when a homogeneous electric field is applied to the cell. The focal length of the microlens arrays is tunable with the applied voltage.

  12. The U.S. Army in a Civil-Military Support Role in Latin America

    DTIC Science & Technology

    1992-06-01

    ESGI) and Peru (Centro de Altos Estudios Militares [CAEM]) and is much the same throughout the region. The major difference in national security 12...the Mexican government, especially President Salinas de Gortari. Mexico has been the host for both the Salvadoran and Guatemalan peace processes...American countries, but if 3 106 Carta de Conducta de Riobamba [Charter of Conduct] presented to the United Nations General Assembly by the Permanent

  13. Continent at a Crossroads: Prosperity, Justice, and Security in South America

    DTIC Science & Technology

    2006-10-01

    ADA416593. (REP LIT AD-A416 593) Dijck, Pitou van. The Bolivian Experiment: Structural Adjustment and Poverty Alleviation . Amsterdam: Centro de Estudios ...and Human Rights. Westport: Praeger, 2002. (F 1418 .G58 2002) 3 Brito, Alexandra Barahona de . Human Rights and Democratization in Latin...JC 599 .U7 B75 1997) Brito, Alexandra Barahona de , Carmen González-Enríquez, and Paloma Aguilar Fernandez, eds. The

  14. Factors That Explain the Attitude towards Statistics in High-School Students: Empirical Evidence at Technological Study Center of the Sea in Veracruz, Mexico

    ERIC Educational Resources Information Center

    Rojas-Kramer, Carlos; Limón-Suárez, Enrique; Moreno-García, Elena; García-Santillán, Arturo

    2018-01-01

    The aim of this paper was to analyze attitude towards statistics in high-school students using the SATS scale designed by Auzmendi (1992). The sample was 200 students from the sixth semester of the afternoon shift, who were enrolled in technical careers from the Technological Study Center of the Sea (Centro de Estudios Tecnológicos del Mar 07…

  15. Multispectral Superconducting Quantum Detectors

    DTIC Science & Technology

    1995-08-01

    Noise 30 2.2.6.3 YBCO QSKIP Noise Equivalent Power 31 2.2.7 Competing LWIR Semiconductor Based Quantum Detectors 33 2.2.8 Conclusions on Operation...spectrum. Of particular interest are photodetectors operating in the midwave 3-5um (MWIR) and longwave 8-12um ( LWIR ) infrared spectra. Interest in...body photon radiation in the MWIR and LWIR spectral bands. With a significant black body photon radiation, passive night imaging and target

  16. The Incorporation of the USA "Science Made Sensible" Programme in South African Primary Schools: A Cross-Cultural Approach to Science Education

    ERIC Educational Resources Information Center

    de Villiers, Rian; Plantan, Tiffany; Gaines, Michael

    2016-01-01

    The Science Made Sensible (SMS) programme began as a partnership between the University of Miami (UM), Florida, USA, and some public schools in Miami. In this programme, postgraduate students from UM work with primary school science teachers to engage learners in science through the use of inquiry-based, hands-on activities. Due to the success of…

  17. OSA Trends in Optics and Photonics Series, Volume 14 Spatial Light Modulators

    DTIC Science & Technology

    1998-05-26

    Extreme Ultraviolet Lithography Glenn D. Kubiak andDon R. Kania, eds. Vol. 5 Optical Amplifiers and Their Applications (1996) Edited by...micromirror device ( DMD ), and photorefractive crystal. Note that other devices not discussed in this article have been developed, such as the charge...earlier. DMDs are fabricated by micromachining a silicon wafer.7 Tiny (16 um X 16 um) suspended mirrors are micromachined on cantilevers. The

  18. VizieR Online Data Catalog: JCMT Gould Belt Survey: W40 complex (Rumble+, 2016)

    NASA Astrophysics Data System (ADS)

    Rumble, D.; Hatchell, J.; Pattle, K.; Kirk, H.; Wilson, T.; Buckle, J.; Berry, D. S.; Broekhoven-Fiene, H.; Currie, M. J.; Fich, M.; Jenness, T.; Johnstone, D.; Mottram, J. C.; Nutter, D.; Pineda, J. E.; Quinn, C.; Salji, C.; Tisi, S.; Walker-Smith, S.; di, Francesco J.; Hogerheijde, M. R.; Ward-Thompson, D.; Bastien, P.; Bresnahan, D.; Butner, H.; Chen, M.; Chrysostomou, A.; Coude, S.; Davis, C. J.; Drabek-Maunder, E.; Duarte-Cabral, A.; Fiege, J.; Friberg, P.; Friesen, R.; Fuller, G. A.; Graves, S.; Greaves, J.; Gregson, J.; Holland, W.; Joncas, G.; Kirk, J. M.; Knee, L. B. G.; Mairs, S.; Marsh, K.; Matthews, B. C.; Moriarty-Schieven, G.; Mowat, C.; Rawlings, J.; Richer, J.; Robertson, D.; Rosolowsky, E.; Sadavoy, S.; Thomas, H.; Tothill, N.; Viti, S.; White, G. J.; Wouterloot, J.; Yates, J.; Zhu, M.

    2017-11-01

    Aquila was observed with SCUBA-2 (Holland et al., 2013MNRAS.430.2513H) between 2012 April 21 and July 5 as part of the JCMT GBS MJLSG33 SCUBA-2 Serpens Campaign. Four separate fully sampled 30 arcmin diameter circular continuum observations (PONG1800 mapping mode) were taken simultaneously at 850um and 450um, and subsequently combined into mosaics. (3 data files).

  19. Solid State Research

    DTIC Science & Technology

    1985-02-15

    Wave Mach-Zehnder Interferometric Modulator with Center-Tapped Electrode. The Two Y Junctions have 2° Full Branching Angles, and the Direction of...and < 110> Directions 20 3-6 Nomarski Micrographs of Seeded 50-/um Ge-on-Insulator Islands After ZMR and Defect Etching 21 3-7 Scanning Electron...achieved to date in this long- wavelength region. A LiNb03 guided-wave interferometric modulator has been demonstrated at A. = 3.39 /um with a

  20. Downstream of downtown: urban wastewater as groundwater recharge

    NASA Astrophysics Data System (ADS)

    Foster, S. S. D.; Chilton, P. J.

    Wastewater infiltration is often a major component of overall recharge to aquifers around urban areas, especially in more arid climates. Despite this, such recharge still represents only an incidental (or even accidental) byproduct of various current practices of sewage effluent handling and wastewater reuse. This topic is reviewed through reference to certain areas of detailed field research, with pragmatic approaches being identified to reduce the groundwater pollution hazard of these practices whilst attempting to retain their groundwater resource benefit. Since urban sewage effluent is probably the only `natural resource' whose global availability is steadily increasing, the socioeconomic importance of this topic for rapidly developing urban centres in the more arid parts of Asia, Africa, Latin America and the Middle East will be apparent. L'infiltration des eaux usées est souvent la composante essentielle de toute la recharge des aquifères des zones urbaines, particulièrement sous les climats les plus arides. Malgré cela, une telle recharge ne constitue encore qu'un sous-produit incident, ou même accidentel, de pratiques courantes variées du traitement de rejets d'égouts et de réutilisation d'eaux usées. Ce sujet est passé en revue en se référant à certaines régions étudiées en détail, par des approches pragmatiques reconnues pour permettre de réduire les risques de pollution des nappes dues à ces pratiques tout en permettant d'en tirer profit pour leur ressource en eau souterraine. Puisque les effluents d'égouts urbains sont probablement la seule « ressource naturelle » dont la disponibilité globale va croissant constamment, l'importance socio-économique de ce sujet est évidente pour les centres urbains à développement rapide de l'Asie, de l'Afrique, de l'Amérique latine et du Moyen-Orient. La infiltración de aguas residuales es a menudo un componente principal de la recarga total en acuíferos ubicados en torno a zonas urbanas, especialmente en los climas más áridos. A pesar de ello, dicho componente todavía es una consecuencia secundaria (o incluso accidental) de diversas prácticas asociadas con la manipulación de las aguas residuales y con la reutilitzación de aguas depuradas. Este tema se revisa mediante referencias a ciertas áreas en las que existen investigación detallada de campo, identificando enfoques pragmáticos con el fin de reducir el riesgo de contaminación de las aguas subterráneas por tales prácticas, a la vez tratando de conservar los beneficios para los recursos del acuífero. Dado que los efluentes de aguas residuales urbanas son probablemente la única `fuente natural' cuya disponibilidad global se halla en del aumento, la importancia socioeconómica de este tema será evidente para los centros urbanos de rápido desarrollo en Asia, Latinoamérica y Oriente Medio.

  1. Quantitative protein expression analysis of CLL B cells from mutated and unmutated IgV(H) subgroups using acid-cleavable isotope-coded affinity tag reagents.

    PubMed

    Barnidge, David R; Jelinek, Diane F; Muddiman, David C; Kay, Neil E

    2005-01-01

    Relative protein expression levels were compared in leukemic B cells from two patients with chronic lymphocytic leukemia (CLL) having either mutated (M-CLL) or unmutated (UM-CLL) immunoglobulin variable heavy chain genes (IgV(H)). Cells were separated into cytosol and membrane protein fractions then labeled with acid-cleavable ICAT reagents (cICAT). Labeled proteins were digested with trypsin then subjected to SCX and affinity chromatography followed by LC-ESI-MS/MS analysis on a linear ion trap mass spectrometer. A total of 9 proteins from the cytosol fraction and 4 from the membrane fraction showed a 3-fold or greater difference between M-CLL and UM-CLL and a subset of these were examined by Western blot where results concurred with cICAT abundance ratios. The abundance of one of the proteins in particular, the mitochondrial membrane protein cytochrome c oxidase subunit COX G was examined in 6 M-CLL and 6 UM-CLL patients using western blot and results showed significantly greater levels (P < 0.001) in M-CLL patients vs UM-CLL patients. These results demonstrate that stable isotope labeling and mass spectrometry can complement 2D gel electrophoresis and gene microarray technologies for identifying putative and perhaps unique prognostic markers in CLL.

  2. Validation of the A&D UM-201 device for office blood pressure measurement according to the European Society of Hypertension International Protocol Revision 2010.

    PubMed

    Fania, Claudio; Albertini, Federica; Palatini, Paolo

    2017-08-01

    The aim of this study was to determine the accuracy of the A&D UM-201 device coupled to several cuffs for different arm sizes for office blood pressure (BP) measurement according to the International Protocol of the European Society of Hypertension. Evaluation was carried out in 33 individuals. The mean age of the individuals was 59.3±13.2 years, systolic BP was 145.4±20.6 mmHg (range: 109-186 mmHg), diastolic BP was 87.3±18.0 mmHg (range: 50-124 mmHg), and arm circumference was 30.4±4.2 cm (range: 23-39 cm). The protocol requirements were followed precisely. The UM-201 monitor passed all requirements, fulfilling the standards of the protocol. On average, the device overestimated systolic BP by 3.0±2.1 mmHg and diastolic BP by 2.6±2.0 mmHg. These data show that the A&D UM-201 device coupled to several cuffs for different ranges of arm circumference fulfilled the requirements for validation by the International Protocol and can be recommended for clinical use in the adult population.

  3. VizieR Online Data Catalog: 12um ISOCAM survey of the ESO-Sculptor field (Seymour+, 2007)

    NASA Astrophysics Data System (ADS)

    Seymour, N.; Rocca-Volmerange, B.; de Lapparent, V.

    2007-11-01

    We present a detailed reduction of a mid-infrared 12um (LW10 filter) ISOCAM open time observation performed on the ESO-Sculptor Survey field (Arnouts et al., 1997A&AS..124..163A). A complete catalogue of 142 sources (120 galaxies and 22 stars), detected with high significance (equivalent to 5{sigma}), is presented above an integrated flux density of 0.31mJy. Star/galaxy separation is performed by a detailed study of colour-colour diagrams. The catalogue is complete to 1mJy and, below this flux density, the incompleteness is corrected using two independent methods. The first method uses stars and the second uses optical counterparts of the ISOCAM galaxies; these methods yield consistent results. We also apply an empirical flux density calibration using stars in the field. For each star, the 12um flux density is derived by fitting optical colours from a multi-band {chi}2 to stellar templates (BaSel-2.0) and using empirical optical-IR colour-colour relations. This article is a companion analysis to our 2007 paper (Rocca-Volmerange et al. 2007A&A...475..801R) where the 12um faint galaxy counts are presented and analysed per galaxy type with the evolutionary code PEGASE.3. (1 data file).

  4. Fontes binárias supermoles de raios X

    NASA Astrophysics Data System (ADS)

    Pires, A. M.; Janot Pacheco, E.

    2003-08-01

    Estuda-se as características físicas das fontes supermoles (de raios X (SSS), utilizando dados ópticos e em altas energias, no âmbito de um trabalho de IC. Trata-se de binárias que apresentam espectro X muito mole, baixas temperaturas e altas luminosidades bolométricas. Esse sistemas são compostos por uma anã branca realizando fusão em sua superfície, a partir de matéria perdida pela estrela companheira. Os resíduos de fusão se acumulam na superfície da anã branca, e essa pode ultrapassar o limite de Chadrasekhar, produzir um colapso gravitacional, sendo esse um dos cenários propostos para as explosões de SN Ia. Apresentamos nesta comunicação o estado da arte das características físicas das fontes SSS, situando-as no âmbito das VCs. Procuramos também situar esses objetos em relação às variáveis galácticas V Sge, na medida em que os dois grupos apresentam certas caracerísticas bastante semelhantes.A metodologia adotada é aquela pedagógico-cognitiva clássica de um trabalho de IC na área de ciências exatas.

  5. Effects of relaxation on depression levels in women with high-risk pregnancies: a randomised clinical trial.

    PubMed

    Araújo, Wanda Scherrer de; Romero, Walckiria Garcia; Zandonade, Eliana; Amorim, Maria Helena Costa

    2016-09-09

    to analyse the effects of relaxation as a nursing intervention on the depression levels of hospitalised women with high-risk pregnancies. a randomised clinical trial realised in a reference centre for high-risk pregnancies. The sample consisted of 50 women with high-risk pregnancies (25 in the control group and 25 in the intervention group). The Benson relaxation technique was applied to the intervention group for five days. Control variables were collected using a predesigned form, and the signs and symptoms of depression were evaluated using the Edinburgh Postnatal Depression Scale (EPDS). The Statistical Package for Social Sciences (SPSS), version 20.0, was used with a significance level of 5%. The Wilcoxon and paired t-tests were used to evaluate depression levels between two timepoints. Using categorical data, the McNemar test was used to analyse differences in depression severity before and after the intervention. depression levels decreased in the intervention group five days after the relaxation technique was applied (4.5 ± 3, p<0.05) compared with the levels at the first timepoint (10.3±5.9). as a nursing intervention, relaxation was effective in decreasing the symptoms of depression in hospitalised women with high-risk pregnancies. analisar os efeitos do relaxamento como uma intervenção de enfermagem sobre os níveis de depressão de mulheres internadas com gravidez de alto risco. ensaio clínico randomizado realizado em um centro de referência para gravidez de alto risco A amostra foi composta de 50 mulheres com gravidez de alto risco (25 no grupo controle e 25 no grupo intervenção). A técnica de relaxamento de Benson foi aplicada ao grupo intervenção por cinco dias. Variáveis de controle foram coletados por meio de um formulário previamente desenvolvido e os sinais e sintomas de depressão foram avaliados usando o Edinburgh Postnatal depression Scale (EPDS). O Statistical Package for the Social Sciences (SPSS), versão 20.0, foi utilizado com nível de significância de 5%. Os testes de Wilcoxon e t pareado foram utilizados para avaliar os níveis de depressão entre os dois momentos. Em relação aos dados categóricos, foi utilizado o teste de McNemar para analisar diferenças na gravidade da depressão antes e depois da intervenção. os níveis de depressão diminuíram no grupo intervenção cinco dias após a aplicação da técnica de relaxamento (4.5±3, p<0.05) em comparação sos níveis do primeiro momento (10.3±5.9). como uma intervenção de enfermagem, o relaxamento foi eficaz na diminuição dos sintomas de depressão em mulheres internadas com gravidez de alto risco. analizar los efectos de la relajación como una intervención de enfermería sobre los niveles de depresión de mujeres hospitalizadas con embarazos de alto riesgo. un ensayo clínico aleatorizado realizado en un centro de referencia para embarazos de alto riesgo. La muestra consistía en 50 mujeres con embarazos de alto riesgo (25 en el grupo control y 25 en el grupo de intervención). Se aplicó la técnica de relajación de Benson al grupo de intervención durante cinco días. Las variables control se recogieron usando un formulario prediseñado, y los signos y síntomas de depresión se evaluaron usando la Escala de Depresión Postparto de Edimburgo (EDPE, Edinburgh Postnatal Depression Scale - EPDS). El Paquete Estadístico para Ciencias Sociales (SPSS, del inglés Statistical Package for Social Sciences), versión 20.0, se usó con un nivel de significación del 5%. La prueba de Wilcoxon y la prueba de t de Student pareada se usaron para evaluar los niveles de depresión entre dos puntos en el tiempo. Usando datos categóricos, la prueba de McNemar se usó para analizar diferencias en la severidad de la depresión antes y después de la intervención. los niveles de depresión disminuyeron en el grupo de intervención a los cinco días después de que la técnica de relajación fuera aplicada (4.5 ± 3, p<0.05) en comparación con los niveles del primer tiempo (10.3±5.9). como una intervención de enfermería, la relajación fue efectiva en la reducción de los síntomas de depresión en mujeres hospitalizadas con embarazos de alto riesgo.

  6. [Clinical study of fire acupuncture with centro-square needles for knee osteoarthritis].

    PubMed

    Wang, Bing; Hu, Jing; Zhang, Ning; Wang, Jingjing; Chen, Zhongjie; Wu, Zhongchao

    2017-05-12

    To compare the efficacy difference between fire acupuncture with centro-square needles (FACSN) and filiform needling (FN) for knee osteoarthritis (KOA). Seventy-two patients were randomly assigned into an FACSN group and an FN group, 36 cases in each one. Ashi points, Xuehai (SP 10), Liangqiu (ST 34), Neixiyan (EX-LE 4), Dubi (ST 35), Zusanli (ST 36), Yanglingquan (GB 34) and Yinlingquan (SP 9) were selected in the two groups. The FACSN group was treated with FACSN, and three acupoints were selected for each treatment; the FN group was treated with FN, and all the acupoints were selected for each treatment. The cupping treatment was given after acupuncture in the two groups. The treatment was given once every other day, without treatment on Sundays. The treatment was given three times a week, 6 times as one course; totally 2 courses were provided. The visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were observed in the two groups before treatment, two weeks, four weeks into treatment and at one-month follow-up visit. In addition, the comprehensive efficacy was compared between the two groups. Compared before treatment, the score of VAS and the total score of WOMAC were improved in the two groups at each time point after treatment (all P <0.01); the scores of VAS at each time point after treatment in FACSN group were lower than those in the FN group (all P <0.05); four weeks into treatment and at one-month follow-up visit, the total score of WOMAC in the FACSN group was lower than that in the FN group (both P <0.05). Two weeks into treatment, the total effective rate was 88.9% (32/36) in the FACSN group, which was higher than 61.1% (22/36) in the FN group ( P <0.01); four weeks into treatment and at one-month follow-up visit, the cured and remarkable effective rates were 66.7% (24/36) and 83.3% (30/36) in the FACSN group, which were higher than 41.7% (15/36) and 44.4% (16/36) in the FN group ( P <0.05, P <0.01), respectively. Fire acupuncture with centro-square needles has relatively high cured and remarkable effective rate for KOA, with rapid onset; as for pain relief, the efficacy is superior to filiform needling.

  7. A Large-Telescope Natural Guide Star AO System

    NASA Technical Reports Server (NTRS)

    Redding, David; Milman, Mark; Needels, Laura

    1994-01-01

    None given. From overview and conclusion:Keck Telescope case study. Objectives-low cost, good sky coverage. Approach--natural guide star at 0.8um, correcting at 2.2um.Concl- Good performance is possible for Keck with natural guide star AO system (SR>0.2 to mag 17+).AO-optimized CCD should b every effective. Optimizing td is very effective.Spatial Coadding is not effective except perhaps at extreme low light levels.

  8. Posterior reversible leukoencephalopathy syndrome secondary to hepatic transarterial chemoembolization with doxorubicin drug eluting beads

    PubMed Central

    Kistler, C. Andrew; McCall, Joseph Caleb; Ghumman, Saad Sultan; Ali, Ijlal Akbar

    2014-01-01

    Posterior reversible encephalopathy syndrome (PRES) is a rare complication of transarterial chemoembolization (TACE) used to treat liver metastases and has never been reported in a patient with metastatic uveal melanoma (UM) to the liver. We report the first case of PRES secondary to TACE with drug eluting beads (DEBs) loaded with doxorubicin in a 56-year-old woman with metastatic UM to the liver. PMID:24772346

  9. A Systems Engineering Analysis of Unmanned Maritime Systems for U.S. Coast Guard Missions

    DTIC Science & Technology

    2013-06-01

    accidental, are apparent when considering the Fukushima Daiichi nuclear disaster and its follow -on radiation hazards [52]. In addition, recent increases in...on the maritime domain increases innovative approaches such as UMS will be vital in gaining awareness , especially in remote locations such as the...Horizon oil disaster clean-up employed a limited use of UMS, specifically Remotely Op- erated Vehicles [20]. As oil drilling increases throughout the

  10. Excitation of the three principal spin waves in yttrium iron garnet using a wavelength-specific multi-element antenna

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bang, Wonbae; Jungfleisch, Matthias B.; Lim, Jinho

    We report systematic measurements of the dispersion of long wavelength spin waves for the magnetic field along the three principal directions (supporting the forward volume, backward volume and Damon-Eshbach modes) of a 3.05 um thick yttrium iron garnet film on a lattice-matched (111) gadolinium gallium garnet substrate obtained using a lithographically patterned, multi-element, 50 um spatially-resonant, antenna.

  11. Excitation of the three principal spin waves in yttrium iron garnet using a wavelength-specific multi-element antenna

    DOE PAGES

    Bang, Wonbae; Jungfleisch, Matthias B.; Lim, Jinho; ...

    2017-12-22

    We report systematic measurements of the dispersion of long wavelength spin waves for the magnetic field along the three principal directions (supporting the forward volume, backward volume and Damon-Eshbach modes) of a 3.05 um thick yttrium iron garnet film on a lattice-matched (111) gadolinium gallium garnet substrate obtained using a lithographically patterned, multi-element, 50 um spatially-resonant, antenna.

  12. Development of a Biosensor Nanofluidic Platform for Integration with Terahertz Spectroscopic System

    DTIC Science & Technology

    2014-06-27

    space. The instrumentation for fabrication of micro/nano-fluidic chips including a Laser-Cutting System, a Sputtering system, a Spin Coating ...polyester (PET) substrate, as PET is more chemically and thermally resistant, and can be readily obtained in a variety of thicknesses down to 12.5 um...to create the array pattern on the silver coated PET substrate. Copper was then electrodeposited to a thickness of 5 um around the photoresist

  13. Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells

    PubMed Central

    Zhang, Yidan; Jia, Renbing; Wang, Jing; Xu, Xiaofang; Yao, Yuting; Ge, Shengfan; Fan, Xianqun

    2013-01-01

    Uveal melanoma (UM) is the most common primary intraocular malignancy and the leading potentially fatal primary intraocular disease in adults. Melanoma antigen recognized by T-cells (MART-1) has been studied extensively as a clinically important diagnostic marker for melanoma, however, its biological function remains unclear. In the present study, the UM cell line SP6.5, which showed a high level of MART-1 expression, was subjected to small interfering RNA-mediated silencing of MART-1. Silencing of MART-1 expression increased the migration ability of SP6.5 cells and down-regulated the expression of the metastasis suppressor NM23. Our results suggest that MART-1 is a candidate target for the development of therapeutic strategies for UM and in particular for the suppression of metastasis associated with this malignancy. PMID:23877836

  14. Increased fracture depth range in controlled spalling of (100)-oriented germanium via electroplating

    DOE PAGES

    Crouse, Dustin; Simon, John; Schulte, Kevin L.; ...

    2018-01-31

    Controlled spalling in (100)-oriented germanium using a nickel stressor layer shows promise for semiconductor device exfoliation and kerfless wafering. Demonstrated spall depths of 7-60 um using DC sputtering to deposit the stressor layer are appropriate for the latter application but spall depths < 5 um may be required to minimize waste for device applications. This work investigates the effect of tuning both electroplating current density and electrolyte chemistry on the residual stress in the nickel and on the achievable spall depth range for the Ni/Ge system as a lower-cost, higher-throughput alternative to sputtering. By tuning current density and electrolyte phosphorousmore » concentration, it is shown that electroplating can successfully span the same range of spalled thicknesses as has previously been demonstrated by sputtering and can reach sufficiently high stresses to enter a regime of thickness (<7 um) appropriate to minimize substrate consumption for device applications.« less

  15. Uh and um in Children With Autism Spectrum Disorders or Language Impairment

    PubMed Central

    Gorman, Kyle; Olson, Lindsay; Presmanes Hill, Alison; Lunsford, Rebecca; Heeman, Peter A.; van Santen, Jan P. H.

    2016-01-01

    Atypical pragmatic language is often present in individuals with autism spectrum disorders (ASD), along with delays or deficits in structural language. This study investigated the use of the “fillers” uh and um by children ages 4–8 during the autism diagnostic observation schedule. Fillers reflect speakers’ difficulties with planning and delivering speech, but they also serve communicative purposes, such as negotiating control of the floor or conveying uncertainty. We hypothesized that children with ASD would use different patterns of fillers compared to peers with typical development or with specific language impairment (SLI), reflecting differences in social ability and communicative intent. Regression analyses revealed that children in the ASD group were much less likely to use um than children in the other two groups. Filler use is an easy-to-quantify feature of behavior that, in concert with other observations, may help to distinguish ASD from SLI. PMID:26800246

  16. Variability of the broad absorption lines in the QSO UM 232

    NASA Technical Reports Server (NTRS)

    Barlow, Thomas A.; Junkkarinen, Vesa T.; Burbidge, E. Margaret

    1989-01-01

    Low-resolution spectra of UM 232 taken in 1978, 1979, and 1988 at Lick Observatory are presented. Large changes in the Si IV lambda 1397, CIV lambda 1549, and Al III lambda 1857 broad absorption lines are apparent. The decrease in column density in all three ions and an observed brightening of the QSO suggests that these changes are due to an increase in the ionization level driven by an increase in the central source luminosity. This mechanism has been proposed by Smith and Penston to explain small changes in the absorption spectrum of the QSO 1246-057. The spectra of UM 232 show that the fractional decrease in optical depth is smaller at higher outflow velocies. The structure of the broad absorption-line region (BALR) is investigted by estimating an ionization parameter for each ion species as a function of velocity.

  17. VizieR Online Data Catalog: Galactic HII region IRAS 16148-5011 content (Mallick+, 2015)

    NASA Astrophysics Data System (ADS)

    Mallick, K. K.; Ojha, D. K.; Tamura, M.; Linz, H.; Samal, M. R.; Ghosh, S. K.

    2015-11-01

    NIR photometric observations in J (1.25um), H (1.63um), and Ks (2.14um) bands (centred on RA=16:18:31, DE=-50:17:32 (2000)) were carried out on 2004 July 29 using the 1.4m Infrared Survey Facility (IRSF) telescope, South Africa. The observations were taken with the help of the Simultaneous InfraRed Imager for Unbiased Survey (SIRIUS) instrument, a three colour simultaneous camera mounted at the f/10 Cassegrain focus of the telescope. Radio continuum observations at 1280MHz were obtained on 2012 November 09 using the Giant Metrewave Radio Telescope (GMRT) array. The GMRT array consists of 30 antennas arranged in an approximate Y-shaped configuration, with each antenna having a diameter of 45m. This translates to a primary beam-size of 26.2-arcmin at 1280MHz. (2 data files).

  18. VizieR Online Data Catalog: The Red MSX Source Survey: massive protostars (Lumsden+, 2013)

    NASA Astrophysics Data System (ADS)

    Lumsden, S. L.; Hoare, M. G.; Urquhart, J. S.; Oudmaijer, R. D.; Davies, B.; Mottram, J. C.; Cooper, H. D. B.; Moore, T. J. T.

    2013-10-01

    The Midcourse Space Experiment (MSX) satellite mission included an astronomy experiment (SPIRIT III) designed to acquire mid-infrared photometry of sources in the Galactic plane (b<5°). MSX had a raw resolution of 18.3", a beam size 50 times smaller than that of IRAS at 12 and 25um. MSX observed six bands between 4 and 21um, of which the four between 8 and 21um are sensitive to astronomical sources. We used v2.3 of the MSX PSC (Egan et al. 2003, Cat. V/114) as our basic input, restricting ourselves to the main Galactic plane catalog, which excludes sources seen in only a single observing pass and those seen in multiple passes but with low significance. We restricted our catalog to 10

  19. The topological matter of holonomy displacement on the principal U(n) -bundle over Dn,m , related to complex surfaces

    NASA Astrophysics Data System (ADS)

    Byun, Taechang

    2018-04-01

    Consider U(n) → U(n , m) / U(m) → π Dn,m , where Dn,m = U(n , m) /(U(n) × U(m)) . Given a nontrivial X ∈Mm×n(C) and g ∈ U(n , m) , consider a complete oriented surface S = S(X , g) with a complex structure in Dn,m and a "new" area form ω (X , g) on the surface S . Let c : [ 0 , 1 ] → S be a smooth, simple, closed, orientation-preserving curve and c ˆ : [ 0 , 1 ] → U(n , m) / U(m) its horizontal lift. Then the holonomy displacement is given by the right action of eΨ for some Ψ ∈SpanR { i(X∗ X)k }k=1p ⊂ u(n) , p =the number of distinct positiveeigenvalues ofX∗ X , such that

  20. Increased fracture depth range in controlled spalling of (100)-oriented germanium via electroplating

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Crouse, Dustin; Simon, John; Schulte, Kevin L.

    Controlled spalling in (100)-oriented germanium using a nickel stressor layer shows promise for semiconductor device exfoliation and kerfless wafering. Demonstrated spall depths of 7-60 um using DC sputtering to deposit the stressor layer are appropriate for the latter application but spall depths < 5 um may be required to minimize waste for device applications. This work investigates the effect of tuning both electroplating current density and electrolyte chemistry on the residual stress in the nickel and on the achievable spall depth range for the Ni/Ge system as a lower-cost, higher-throughput alternative to sputtering. By tuning current density and electrolyte phosphorousmore » concentration, it is shown that electroplating can successfully span the same range of spalled thicknesses as has previously been demonstrated by sputtering and can reach sufficiently high stresses to enter a regime of thickness (<7 um) appropriate to minimize substrate consumption for device applications.« less

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