Spring Chinook Salmon Production for Confederated Tribes of the Umatilla Indian Reservation, Little White Salmon National Fish Hatchery, Annual Report 2006.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doulas, Speros

2007-01-01

This annual report covers the period from January 1, 2006 through December 31, 2006. Work completed supports the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) effort to restore a locally-adapted stock of spring Chinook to the Umatilla River Basin. During the year, staff at the Little White Salmon/Willard National Fish Hatchery Complex have completed the rearing of 218,764 Brood Year 2004 spring Chinook salmon for release into the Umatilla River during spring 2006 and initiated production of approximately 220,000 Brood Year 2005 spring Chinook for transfer and release into the Umatilla River during spring 2007. All work under thismore » contract is performed at the Little White Salmon and Willard National Fish Hatcheries (NFH), Cook, WA.« less

76 FR 26239 - Umatilla National Forest, Walla Walla Ranger District, Oregon, Cobbler II Timber Sale and Fuels...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

... 27, 2011, Umatilla National Forest Supervisor Kevin Martin withdrew his October 8, 2010 Record of.... Responsible Official Forest Supervisor for the Umatilla National Forest, Kevin Martin. Nature of Decision To.... Kevin Martin, Forest Supervisor. [FR Doc. 2011-11097 Filed 5-5-11; 8:45 am] BILLING CODE 3410-11-P ...

Hydrogeologic framework and selected components of the groundwater budget for the upper Umatilla River Basin, Oregon

USGS Publications Warehouse

Herrera, Nora B.; Ely, Kate; Mehta, Smita; Stonewall, Adam J.; Risley, John C.; Hinkle, Stephen R.; Conlon, Terrence D.

2017-05-31

Executive SummaryThis report presents a summary of the hydrogeology of the upper Umatilla River Basin, Oregon, based on characterization of the hydrogeologic framework, horizontal and vertical directions of groundwater flow, trends in groundwater levels, and components of the groundwater budget. The conceptual model of the groundwater flow system integrates available data and information on the groundwater resources of the upper Umatilla River Basin and provides insights regarding key hydrologic processes, such as the interaction between the groundwater and surface water systems and the hydrologic budget.The conceptual groundwater model developed for the study area divides the groundwater flow system into five hydrogeologic units: a sedimentary unit, three Columbia River basalt units, and a basement rock unit. The sedimentary unit, which is not widely used as a source of groundwater in the upper basin, is present primarily in the lowlands and consists of conglomerate, loess, silt and sand deposits, and recent alluvium. The Columbia River Basalt Group is a series of Miocene flood basalts that are present throughout the study area. The basalt is uplifted in the southeastern half of the study area, and either underlies the sedimentary unit, or is exposed at the surface. The interflow zones of the flood basalts are the primary aquifers in the study area. Beneath the flood basalts are basement rocks composed of Paleogene to Pre-Tertiary sedimentary, volcanic, igneous, and metamorphic rocks that are not used as a source of groundwater in the upper Umatilla River Basin.The major components of the groundwater budget in the upper Umatilla River Basin are (1) groundwater recharge, (2) groundwater discharge to surface water and wells, (3) subsurface flow into and out of the basin, and (4) changes in groundwater storage.Recharge from precipitation occurs primarily in the upland areas of the Blue Mountains. Mean annual recharge from infiltration of precipitation for the upper Umatilla River Basin during 1951–2010 is about 9.6 inches per year (in/yr). Annual recharge from precipitation for water year 2010 ranged from 3 in. in the lowland area to about 30 in. in the Blue Mountains. Using Kahle and others (2011) data and methods from the Columbia Plateau regional model, average annual recharge from irrigation is estimated to be about 2.2 in/yr for the 13 square miles of irrigated land in the upper Umatilla River Basin.Groundwater discharges to streams throughout the year and is a large component of annual streamflow in the upper Umatilla River Basin. Upward vertical hydraulic gradients near the Umatilla River indicate the potential for groundwater discharge. Groundwater discharge to the Umatilla River generally occurs in the upper part of the basin, upstream from the main stem.Groundwater development in the upper Umatilla River Basin began sometime after 1950 (Davies-Smith and others, 1988; Gonthier and Bolke, 1991). By water year 2010, groundwater use in the upper Umatilla River Basin was approximately 11,214 acre-feet (acre-ft). Total groundwater withdrawals for the study area were estimated at 7,575 acre-ft for irrigation, 3,173 acre-ft for municipal use, and 466 acre-ft for domestic use.Total groundwater flow into or from the study area depends locally on geology and hydraulic head distribution. Estimates of subsurface flow were calculated using the U.S. Geological Survey Columbia Plateau regional groundwater flow model. Net flux values range from 25,000 to 27,700 acre-ft per year and indicate that groundwater is moving out of the upper Umatilla River Basin into the lower Umatilla River Basin.Water level changes depend on storage changes within an aquifer, and storage changes depend on the storage properties of the aquifer, as well as recharge to or discharge from the aquifer. Groundwater level data in the upper Umatilla River Basin are mostly available from wells in Columbia River basalt units, which indicate areas of long-term water level declines in the Grande Ronde basalt unit near Pendleton and Athena, Oregon. Groundwater levels in the Wanapum basalt unit do not show long-term declines in the upper Umatilla River Basin. Because of pumping, some areas in the upper Umatilla River Basin have shown a decrease, or reversal, in the upward vertical head gradient.Key data needs are improvement of the spatial and temporal distribution of water-level data collection and continued monitoring of streamflow gaging sites. Additionally, refinement of recharge estimates would enhance understanding of the processes that provide the groundwater resources in the upper Umatilla River Basin.

Forest resources of the Umatilla National Forest.

Treesearch

Glenn A. Christensen; Paul Dunham; David C. Powell; Bruce. Hiserote

2007-01-01

Current resource statistics for the Umatilla National Forest, based on two separate inventories conducted in 1993–96 and in 1997–2002, are presented in this report. Currently on the Umatilla National Forest, 89 percent of the land area is classified as forest land. The predominant forest type is grand fir (26 percent of forested acres) followed by the interior Douglas-...

Umatilla River Basin Anadromous Fsh Habitat Enhancement Project : 2000 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaw, R. Todd

2001-12-31

The Umatilla River Basin Anadromous Fish Habitat Enhancement Project continued to identify impacted stream reaches throughout the Umatilla River Basin for habitat improvements during the 2000 project period. Public outreach efforts, biological and physical monitoring, and continued development of a Umatilla River Basin Watershed Assessment assisted the project in fostering public cooperation, targeting habitat deficiencies and determining habitat recovery measures. Habitat enhancement projects continued to be maintained on 44 private properties, four riparian easements and one in-stream enhancement agreement were secured, two new projects implemented and two existing projects improved to enhance anadromous fish habitat and natural fisheries production capabilitiesmore » in the Umatilla River Basin. New project locations included sites on the mid Umatilla River and Buckaroo Creek. Improvements were implemented at existing project sites on the upper Umatilla River and Wildhorse Creek. A stream bank stabilization project was implemented at approximately River Mile 37.4 Umatilla River to stabilize 760 feet of eroding stream bank and improve in-stream habitat diversity. Habitat enhancements at this site included construction of six rock barbs with one large conifer root wad incorporated into each barb, stinging approximately 10,000 native willow cuttings, planting 195 tubling willows and 1,800 basin wildrye grass plugs, and seeding 40 pounds of native grass seed. Staff time to assist in development of a subcontract and fence materials were provided to establish eight spring sites for off-stream watering and to protect wetlands within the Buckaroo Creek Watershed. A gravel bar was moved and incorporated into an adjacent point bar to reduce stream energy and stream channel confinement within the existing project area at River Mile 85 Umatilla River. Approximately 10,000 native willow cuttings were stung and trenched into the stream channel margins and stream banks, and 360 basin wildrye grass plugs planted and 190 pounds of native grass seed broadcast on terraces between River Mile 10 and 12.5 within the existing Wildhorse Creek Project Area. Approximately 70 pounds of native grasses were seeded in the existing McKay Creek Project Area at approximately River Mile 21.5. Financial and in-kind cost share assistance was provided by the Confederated Tribes of the Umatilla Indian Reservation, U.S. Bureau of Indian Affairs, U.S. Department of Agriculture, U.S. Fish and Wildlife Service, National Fish and Wildlife Federation and the Umatilla National Forest for the enhancements at River Mile 37.4 Umatilla River and within the Buckaroo Creek Watershed. Monitoring continued to quantify effects of habitat enhancements in the upper basin. Maximum, minimum and average daily stream temperatures were collected from June through September at 22 sites. Suspended sediment samples were obtained at three gage stations to arrive at daily sediment load estimates. Photographs were taken at 94 existing and two newly established photo points to document habitat recovery. Umatilla Basin Watershed Assessment efforts were continued under a subcontract with Washington State University. This endeavor involves compiling existing information, identifying data gaps, determining habitat-limiting factors and recommending actions to improve anadromous fisheries habitat. This watershed assessment document and working databases will be completed in fiscal year 2002 and made available to assist project personnel with sub-watershed prioritization of habitat needs.« less

17. Photocopy of original USRS photograph (from original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of original USRS photograph (from original print in the Umatilla Project History 1920, on file at National Archives, Rocky Mountain Region, Denver, Colorado) Photographer unknown, ca. 1920. Project office and employees - reading from left to right: Una H. Keck, Geo. C. Patterson, H.M. Schilling, Maurice D. Scroggs, Carl M. Voyen, Chas. Taylor, C.D. Porter - Former Umatilla Project Headquarters Buildings, Office, Hermiston, Umatilla County, OR

Umatilla Hatchery Monitoring and Evaluation, 1999-2002 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chess, Dale W.; Cameron, William A.; Stonecypher, Jr., R. Wes

2003-12-01

REPORT A: UMATILLA HATCHERY MONITORING AND EVALUATION--This report summarizes monitoring and evaluation studies of salmonids reared at Umatilla Fish Hatchery (UFH) for 1 November, 1999 to 31 October, 2002. Studies at UFH are designed to evaluate rearing of chinook salmon and steelhead in ''Michigan raceways''. Characteristics of Michigan raceways include high fish densities, rapid water turnover, oxygen supplementation, reuse of water, and baffles designed to reduce cleaning. Fish health at UFH and other facilities associated with the Umatilla program are intensively monitored and evaluated along with the overall research project. Further, under the Integrated Hatchery Operations Team guidelines, specific requirementsmore » for fish health monitoring at UFH are mandatory. An experiment designed to evaluate rearing subyearling fall chinook salmon in Michigan and Oregon raceways has been completed. An evaluation of survival of subyearling fall chinook salmon reared at three densities will be completed with final returns in 2005. Two new evaluations were started during this reporting period. The first is an evaluation of spring chinook survival of groups transferred to Imeques acclimation facility in the fall, overwinter-acclimated and released with the standard acclimated production groups in March. The second is an evaluation of subyearling fall chinook survival and straying of a direct-stream released group in the lower Umatilla River and the standard group acclimated at Thornhollow acclimation facility in the upper Umatilla River. An important aspect of the project is evaluation of the spring chinook and summer steelhead fisheries in the upper and lower Umatilla River. REPORT B: Fish Health Monitoring and Evaluation, 2000 Fiscal Year--The results presented in this report are from the ninth year of Fish Health Monitoring and Evaluation in the Umatilla Hatchery program. Broodstock monitoring for hatchery production was conducted on adult returns to the Umatilla River at Three Mile Dam and South Fork Walla Walla adult facilities for salmon; steelhead adults were monitored at Minthorn adult facility. A new addition to this year's report is the effort to bring together an overview of fish health monitoring results including historical and year to date pathogen information. This information is in table form (Appendix Tables A-28, A-29 and A-30). A summary of juvenile disease outbreaks at Umatilla Hatchery is also included (Appendix Table A-31). REPORT C: Fish Health Monitoring and Evaluation, 2001 Fiscal Year--Results from the 2001 annual report cover the 10th year of Fish Health Monitoring in the Umatilla Hatchery program. Efforts were again made to provide up to date fish health and juvenile disease outbreak loss summary tables from the beginning of the Umatilla Hatchery program (Appendix Tables A-27, A-28, A-29 and A-30). Outmigrant Fish Health Monitoring results were included in this report since this was part of the fish health work statement for this report period. The discussion section for the 2001 and 2002 annual reports are combined in the 2002 report due to time constraints and consolidation efforts to complete this report by the end of May 2003.« less

Umatilla River Basin Anadromous Fish Habitat Enhancement Project : 2001 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaw, R. Todd; Sexton, Amy D.

The Umatilla River Basin Anadromous Fish Habitat Enhancement Project continued to identify impacted stream reaches throughout the Umatilla River Basin for habitat improvements during the 2001 project period. Public outreach efforts, biological and physical monitoring, and continued development of a Umatilla Subbasin Watershed Assessment assisted the project in fostering public cooperation, targeting habitat deficiencies and determining habitat recovery measures. Projects continued to be maintained on 49 private properties, one 25-year Non-Exclusive Bureau of Indian Affairs' Easement was secured, six new projects implemented and two existing project areas improved to enhance anadromous fish habitat. New project locations included sites on themore » mid Umatilla River, upper Umatilla River, Mission Creek, Cottonwood Creek and Buckaroo Creek. New enhancements included: (1) construction of 11,264 feet of fencing between River Mile 43.0 and 46.5 on the Umatilla River, (2) a stream bank stabilization project implemented at approximately River Mile 63.5 Umatilla River to stabilize 330 feet of eroding stream bank and improve instream habitat diversity, included construction of eight root wad revetments and three boulder J-vanes, (3) drilling a 358-foot well for off-stream livestock watering at approximately River Mile 46.0 Umatilla River, (4) installing a 50-foot bottomless arch replacement culvert at approximately River Mile 3.0 Mission Creek, (5) installing a Geoweb stream ford crossing on Mission Creek (6) installing a 22-foot bottomless arch culvert at approximately River Mile 0.5 Cottonwood Creek, and (7) providing fence materials for construction of 21,300 feet of livestock exclusion fencing in the Buckaroo Creek Drainage. An approximate total of 3,800 native willow cuttings and 350 pounds of native grass seed was planted at new upper Umatilla River, Mission Creek and Cottonwood Creek project sites. Habitat improvements implemented at existing project sites included development of a 105-foot well for off-stream livestock watering at approximately River Mile 12.0 Wildhorse Creek and construction of an engineered stream ford at approximately River Mile 3.0 Mission Creek. A total of $277,848 in financial cost share assistance was provided by the Confederated Tribes of the Umatilla Indian Reservation, U.S. Bureau of Indian Affairs, U.S. Environmental Protection Agency, U.S. Department of Agriculture, National Oceanic and Atmospheric Administration, U.S. Workforce Investment Act, Oregon Watershed Enhancement Board, Umatilla County and Pheasants Forever for planning efforts and habitat enhancements. Monitoring continued to quantify baseline conditions and the effects of habitat enhancements in the upper basin. Daily stream temperatures were collected from June through September at 22 sites. Suspended sediment samples were obtained at three gage stations to arrive at daily sediment load estimates. Photographs were taken at 96 existing and three newly established photo points to document habitat recovery and pre-project conditions. Transects were measured at three stream channel cross sections to assist with engineering and design and to obtain baseline data regarding channel morphology. Biological inventories were conducted at River Mile 3.0 Mission Creek to determine pre-project fish utilization above and below the passage barrier. Post-project inventories were also conducted at River Mile 85.0 of the Umatilla River at a project site completed in 1999. Umatilla Subbasin Watershed Assessment efforts were continued under a subcontract with Eco-Pacific. This watershed assessment document and working databases will be completed in fiscal year 2002 and made available to assist project personnel with sub-watershed prioritization of habitat needs. Water Works Consulting, Duck Creek Associates and Ed Salminen Consulting were subcontracted for watershed assessment and restoration planning in the Meacham Creek Subwatershed. A document detailing current conditions in the Meacham Creek Subwatershed and necessary restoration actions will be available for review in 2003.« less

75 FR 64243 - Umatilla National Forest, Walla Walla Ranger District; Oregon Tollgate Fuels Reduction Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

... trees; however, larger trees may be removed as necessary to meet project objectives. Activities within... through the removal of standing (live and dead) trees and dead and down material. These activities would...

General setting from alley, office to left, concrete structure in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General setting from alley, office to left, concrete structure in center foreground, garage/shop to right, view to northeast - Former Umatilla Project Headquarters Buildings, Hermiston, Umatilla County, OR

Remediation System Design Optimization: Field Demonstration at the Umatilla Army Deport

NASA Astrophysics Data System (ADS)

Zheng, C.; Wang, P. P.

2002-05-01

Since the early 1980s, many researchers have shown that the simulation-optimization (S/O) approach is superior to the traditional trial-and-error method for designing cost-effective groundwater pump-and-treat systems. However, the application of the S/O approach to real field problems has remained limited. This paper describes the application of a new general simulation-optimization code to optimize an existing pump-and-treat system at the Umatilla Army Depot in Oregon, as part of a field demonstration project supported by the Environmental Security Technology Certification Program (ESTCP). Two optimization formulations were developed to minimize the total capital and operational costs under the current and possibly expanded treatment plant capacities. A third formulation was developed to minimize the total contaminant mass of RDX and TNT remaining in the shallow aquifer by the end of the project duration. For the first two formulations, this study produced an optimal pumping strategy that would achieve the cleanup goal in 4 years with a total cost of 1.66 million US dollars in net present value. For comparison, the existing design in operation was calculated to require 17 years for cleanup with a total cost of 3.83 million US dollars in net present value. Thus, the optimal pumping strategy represents a reduction of 13 years in cleanup time and a reduction of 56.6 percent in the expected total expenditure. For the third formulation, this study identified an optimal dynamic pumping strategy that would reduce the total mass remaining in the shallow aquifer by 89.5 percent compared with that calculated for the existing design. In spite of their intensive computational requirements, this study shows that the global optimization techniques including tabu search and genetic algorithms can be applied successfully to large-scale field problems involving multiple contaminants and complex hydrogeological conditions.

25 CFR 247.3 - Who is eligible to use the sites?

Code of Federal Regulations, 2012 CFR

2012-04-01

... Confederated Tribes and Bands of the Yakima Indian Nation (Yakima), the Confederated Tribes of the Warm Springs Reservation of Oregon (Warm Springs), the Confederated Tribes of the Umatilla Indian Reservation (Umatilla...

25 CFR 247.3 - Who is eligible to use the sites?

Code of Federal Regulations, 2013 CFR

2013-04-01

... Confederated Tribes and Bands of the Yakima Indian Nation (Yakima), the Confederated Tribes of the Warm Springs Reservation of Oregon (Warm Springs), the Confederated Tribes of the Umatilla Indian Reservation (Umatilla...

25 CFR 247.3 - Who is eligible to use the sites?

Code of Federal Regulations, 2011 CFR

2011-04-01

... Confederated Tribes and Bands of the Yakima Indian Nation (Yakima), the Confederated Tribes of the Warm Springs Reservation of Oregon (Warm Springs), the Confederated Tribes of the Umatilla Indian Reservation (Umatilla...

25 CFR 247.3 - Who is eligible to use the sites?

Code of Federal Regulations, 2010 CFR

2010-04-01

... Confederated Tribes and Bands of the Yakima Indian Nation (Yakima), the Confederated Tribes of the Warm Springs Reservation of Oregon (Warm Springs), the Confederated Tribes of the Umatilla Indian Reservation (Umatilla...

25 CFR 247.3 - Who is eligible to use the sites?

Code of Federal Regulations, 2014 CFR

2014-04-01

... Confederated Tribes and Bands of the Yakima Indian Nation (Yakima), the Confederated Tribes of the Warm Springs Reservation of Oregon (Warm Springs), the Confederated Tribes of the Umatilla Indian Reservation (Umatilla...

Effects of heptachlor-treated cereal grains on Canada geese in the Columbia Basin

USGS Publications Warehouse

Blus, L.J.; Henny, C.J.; Lenhart, D.J.; Cromartie, E.; Jarvis, Robert L.; Bartonek, James C.

1979-01-01

In 1976 and 1977, die-offs of birds of several species occurred in Umatilla and Morrow counties, Oregon. Detection of high levels of heptachlor epoxide (HE) in tissues of Canada geese (Branta canadensis) prompted this study to determine the extent and impact of heptachlor contamination on geese on two study areas on the Columbia River--the Umatilla National Wildlife Refuge (Umatilla) in Oregon and Washington and on the McNary Recreation Area (McNary) about 65 km upstream in Washington. Nest success of Great Basin Canada geese (B. c. moffitti) at McNary was 90.2 percent compared to 5I.7 percent at Umatilla. HE in eggs was correlated with nest success--95 percent of the nests from which sample eggs contained 10 ug/g. Eggs from McNary were essentially clean of organochlorine pollutants, while eggs from Umatilla contained an average of 2.93 ?g/g of HE and a maximum of 24.29 ug/g. Lethal levels of HE were detected in brains of resident Great Basin Canada geese and over-wintering Taverner's geese (B. c. taverneri) that were found dead on or near Umatilla: The source of HE in geese appeared to be ingestion of seeds treated with heptachlor for wireworm control. The small population of moffitti is in danger of extirpation from heptachlor. Recommendations for minimizing the heptachlor problem include: (1) improved handling of treated grain to decrease its availability to wildlife, (2) use of treated seed only in areas requiring wireworm control, and cessation of prophylactic use, particularly on wheat planted in irrigated circles immediately following potatoes, and (3) replacement of heptachlor with a safer chemicaL

Umatilla River Subbasin Fish Habitat Improvement Program, 2004-2005 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

St. Hilaire, Danny R.

This annual report is in fulfillment of contractual obligations with Bonneville Power Administration (BPA), which is the funding source for the Oregon Department of Fish and Wildlife's (ODFW), Umatilla River Subbasin Fish Habitat Improvement Program (Program). The Program works cooperatively with private landowners to develop long-term restoration, under which, passive and active Habitat Improvement Projects are conducted. Historically, projects have included livestock exclusion fencing (passive restoration) to protect riparian habitats, along with the installation of instream structures (active restoration) to address erosion and improve fish habitat. In recent years, the focus of active restoration has shifted to bioengineering treatments and,more » more recently, to channel re-design and reconstruction aimed at improving fish habitat, by restoring stable channel function. This report provides a summary of Program activities for the 2004 calendar year (January 1 through December 31, 2004), within each of the four main project phases, including: (1) Implementation--Pre-Work, (2) Implementation--On Site Development, (3) Operation and Maintenance, and (4) Monitoring and Evaluation. This report also summarizes Program Administrative, Interagency Coordination, and Public Education activities.« less

Appendix: Assessment of watershed vulnerability to climate change - Pilot National Forest reports

Treesearch

Michael J. Furniss; Ken B. Roby; Dan Cenderelli; John Chatel; Caty F. Clifton; Alan Clingenpeel; Polly E. Hays; Dale Higgins; Ken Hodges; Carol Howe; Laura Jungst; Joan Louie; Christine Mai; Ralph Martinez; Kerry Overton; Brian P. Staab; Rory Steinke; Mark Weinhold

2013-01-01

Assessment of watershed vulnerability to climate change. Pilot National Forest reports: Gallatin National Forest, Helena National Forest, Grand Mesa, Uncompahgre, and Gunnison National Forests, White River National Forest, Coconino National Forest, Sawtooth National Forest, Shasta-Trinity National Forest, Umatilla National Forest, Umatilla National Forest, Ouachita...

Depot-specific Regulation of the Conversion of Cortisone to Cortisol in Human Adipose Tissue

PubMed Central

Lee, Mi-Jeong; Fried, Susan K.; Mundt, Steven S.; Wang, Yanxin; Sullivan, Sean; Stefanni, Alice; Daugherty, Bruce L.; Hermanowski-Vosatka, Anne

2015-01-01

Objective Our main objective was to compare the regulation of cortisol production within omental (Om) and abdominal subcutaneous (Abd sc) human adipose tissue. Methods and Procedures Om and Abd sc adipose tissue were obtained at surgery from subjects with a wide range of BMI. Hydroxysteroid dehydrogenase (HSD) activity (3H-cortisone and 3H-cortisol interconversion) and expression were measured before and after organ culture with insulin and/or dexamethasone. Results Type 1 HSD (HSD1) mRNA and reductase activity were mainly expressed within adipocytes and tightly correlated with adipocyte size within both depots. There was no depot difference in HSD1 expression or reductase activity, while cortisol inactivation and HSD2 mRNA expression (expressed in stromal cells) were higher in Om suggesting higher cortisol turnover in this depot. Culture with insulin decreased HSD reductase activity in both depots. Culture with dexamethasone plus insulin compared to insulin alone increased HSD reductase activity only in the Om depot. This depot-specific increase in reductase activity could not be explained by an alteration in HSD1 mRNA or protein, which was paradoxically decreased. However, in Om only, hexose-6-phosphate dehydrogenase (H6PDH) mRNA levels were increased by culture with dexamethasone plus insulin compared to insulin alone, suggesting that higher nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) production within the endoplasmic reticulum (ER) contributed to the higher HSD reductase activity. Discussion We conclude that in the presence of insulin, glucocorticoids cause a depot-specific increase in the activation of cortisone within Om adipose tissue, and that this mechanism may contribute to adipocyte hypertrophy and visceral obesity. PMID:18388900

75 FR 65937 - Fresh Prunes Grown in Designated Counties in Washington and in Umatilla County, OR; Suspension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-27

...The Department of Agriculture (USDA) is adopting, as a final rule, without change, an interim rule that suspended the reporting and assessment requirements prescribed under the Washington-Oregon fresh prune marketing order. The marketing order regulates the handling of fresh prunes grown in designated counties in Washington and in Umatilla County, Oregon, and is administered locally by the Washington-Oregon Fresh Prune Marketing Committee (Committee). On June 1, 2010, the Committee unanimously voted to terminate Marketing Order No. 924. Since the only regulatory actions then in effect were the reporting and assessment requirements, the Committee included a recommendation to immediately suspend those activities while USDA processes the termination request. The reporting and assessment requirements will remain suspended until reinstated or permanently terminated.

76 FR 55001 - Intent To Prepare an Environmental Impact Statement; Umatilla National Forest, Walla Walla Ranger...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... authorities of the Healthy Forest Restoration Act (HFRA) of 2004. After the initial request for public comment... and treatment of fuels within select Riparian Habitat Conservation Areas (RHCAs). RHCA treatment is... objectives were identified based on the intent of the 2004 Healthy Forest Restoration Act, the Umatilla...

In-Space Cryogenic Propellant Depot (ISCPD) Architecture Definitions and Systems Studies

NASA Technical Reports Server (NTRS)

Fikes, John C.; Howell, Joe T.; Henley, Mark

2006-01-01

The objectives of the ISCPD Architecture Definitions and Systems Studies were to determine high leverage propellant depot architecture concepts, system configuration trades, and related technologies to enable more ambitious and affordable human and robotic exploration of the Earth Neighborhood and beyond. This activity identified architectures and concepts that preposition and store propellants in space for exploration and commercial space activities, consistent with Exploration Systems Research and Technology (ESR&T) objectives. Commonalities across mission scenarios for these architecture definitions, depot concepts, technologies, and operations were identified that also best satisfy the Vision of Space Exploration. Trade studies were conducted, technology development needs identified and assessments performed to drive out the roadmap for obtaining an in-space cryogenic propellant depot capability. The Boeing Company supported the NASA Marshall Space Flight Center (MSFC) by conducting this Depot System Architecture Development Study. The primary objectives of this depot architecture study were: (1) determine high leverage propellant depot concepts and related technologies; (2) identify commonalities across mission scenarios of depot concepts, technologies, and operations; (3) determine the best depot concepts and key technology requirements and (4) identify technology development needs including definition of ground and space test article requirements.

Changes in planform geomorphology and vegetation of the Umatilla River during a 50-year period of diminishing peak flow

NASA Astrophysics Data System (ADS)

Hughes, M. L.; McDowell, P. F.

2017-12-01

The Umatilla River of northeastern Oregon is a gravel-bedded, mixed pattern, salmonid-bearing channel-floodplain system typical of the Interior Columbia River Basin. Efforts to restore native salmonids in this region since the 1980's coupled with increased scrutiny of flood- and erosion-control activities have prompted a need for better understanding of the biogemorphic implications of flood disturbances. The goals of this study are: (1) to re-examine results of earlier studies of flood impacts on the Umatilla River in light of more recent flow records, and (2) to investigate the degree to which large floods have influenced existing patterns of channel-floodplain geomorphology and vegetation. Mapping of flowing channels, bars, scoured surfaces, and vegetation within the active channel from of aerial photos bracketing flood and inter-flood periods since 1964 indicates complex and spatially variable channel changes. In general, channel scour was the most consistent response to flooding. The direction (gain/loss) and magnitude of changes in bars and vegetation within the active channel, as well as the amount of lateral channel movement and changes in sinuosity, were generally inconsistent across flood events. The removal of vegetation by scour during floods was in many areas compensated by the capture of vegetation from the floodplain by avulsion and activation of secondary channels. To date, the geomorphic impacts of the 1964-65 flood-of-record have not been replicated, despite an overall increase in the frequency of smaller floods. Expansion of riparian vegetation in recent decades has mainly occurred in areas disturbed by scour and bar deposition during the 1964-65 floods. Vegetative succession during this period has caused contraction of the active channel such that it now appears much as it did before the 1964-65 floods. These results underscore the importance of large floods as drivers of biogeormphic processes and patterns over timescales relevant to river management and restoration.

Effects of heptachlor- and lindane-treated seed on Canada geese

USGS Publications Warehouse

Blus, L.J.; Henny, C.J.; Lenhart, D.J.; Kaiser, T.E.

1984-01-01

A study of Canada geese (B. canadensis) was conducted in the Pacific Northwest from 1978 through 1981. Lowered reproductive success, mortality of adults, and a population decline of resident western Canada geese (B. c. moffitti) at the Umatilla National Wildlife Refuge (Umatilla NWR) Oregon and Washington [USA] were associated with the use of heptachlor-treated wheat. Analyses of eggs and tissues from dead geese provided strong evidence that heptachlor was responsible for the mortality and decreased production. Residues of heptachlor epoxide (HE) in brains of B. c. moffitti found dead in 1978 and 1979 equalled or exceeded the lethal hazard zone of 8-9 .mu.g/g in experimental passerine birds; HE residues of > 10 .mu.g/g in sample eggs were associated with low nest success. The breeding population of Canada geese at Umatilla decreased from 129 pairs in 1974 to about 100 pairs in 1979. The heptachlor problem was restricted to the Umatilla area; HE residues were low in tissues and eggs collected at other sites in Oregon, Washington and Idaho. In Sept., 1979, the use of heptachlor-treated seed was banned in a 1700-km2 area that encompassed both sides of the Columbia River near Umatilla. Lindane was substituted for heptachlor in the restricted area in 1979, and its use was extended to much of the Columbia Basin in 1981. Concurrently, reproductive success of geese increased, mortality decreased, and the nesting population increased to 170 pairs by 1983. There was no evidence for either biomagnification of lindance residues from treated seed to goose tissues or eggs or for induction of adverse effects by this compound.

Activity-Based Management Accounting for DoD Depot Maintenance

DTIC Science & Technology

1994-08-01

used to establish a management accounting system for the depots is described. The current accounting system does not provide the information to answer...nondirect costs are tied solely to direct labor hours. A possible alternative management accounting system uses Activity-Based Costing (ABC). ABC links...along with its probable benefits and costs. Accounting, Management accounting , Cost analysis, Depot maintenance cost.

Deep canyon and subalpine riparian and wetland plant associations of the Malheur, Umatilla, and Wallowa-Whitman National Forests.

Treesearch

Aaron F. Wells

2006-01-01

This guide presents a classification of the deep canyon and subalpine riparian and wetland vegetation types of the Malheur, Umatilla, and Wallowa-Whitman National Forests. A primary goal of the deep canyon and subalpine riparian and wetland classification was a seamless linkage with the midmontane northeastern Oregon riparian and wetland classification provided by...

Umatilla Hatchery Monitoring and Evaluation, 1998-1999 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stonecypher, R. Wess; Groberg, Jr., Warren J.; Farman, Brett M.

2001-07-01

The Northwest Power Planning Council's Columbia River Basin Fish and Wildlife Program authorized construction of Umatilla Fish Hatchery (UFH) in 1986. Measure 703 of the program amended the original authorization for the hatchery and specified evaluation of the Michigan (MI) raceways using oxygen supplementation to reach production goals of 290,000 lb of chinook salmon (Oncorhynchus tshawytscha) and steelhead (O. mykiss). The hatchery was completed in fall 1991. Partial justification for the hatchery was to evaluate new production and supplementation techniques. MI raceways at UFH increase smolt production with a limited water supply. Test results for MI raceways will have systematicmore » application in the Columbia River basin. The UFH is the foundation for rehabilitating chinook salmon and enhancing steelhead in the Umatilla River (CTUIR and ODFW 1990) and is expected to contribute significantly to the Northwest Power Planning Council's goal of doubling salmon production in the Columbia Basin. Hatchery production goals and a comprehensive monitoring and evaluation plan were presented in the Umatilla Hatchery Master Plan (CTUIR and ODFW 1990). The Comprehensive Plan for Monitoring and Evaluation of Umatilla Hatchery (Carmichael 1990) was approved by the Northwest Power Planning Council as a critical adaptive management guide for fisheries rehabilitation in the Umatilla River. Monitoring and evaluation will be used to increase knowledge about uncertainties inherent in the fisheries rehabilitation and will complement the developing systematic monitoring and evaluation program. The monitoring and evaluation goals are: (1) Provide information and recommendations for the culture and release of hatchery fish, harvest regulations, and natural escapement to accomplish long-term natural and hatchery production goals in the Umatilla River basin that are consistent with provisions of the Council's Columbia River Basin Fish and Wildlife Program. (2) Assess the success of achieving the management objectives in the Umatilla River basin that are presented in the Master Plan and the Comprehensive Rehabilitation Plan. A substantial proportion of the production at UFH is reared in MI raceways. This system has not been thoroughly evaluated to determine the effects on Smolt-to-adult survival (SAS). In addition, the rearing strategies proposed for spring chinook salmon require an unusually extensive period of incubation in chilled well water. Extensive background and justification for UFH monitoring and evaluation is presented in Carmichael (1990). In this report, we present findings for the UFH Monitoring and Evaluation Project from 1 November 1998 to 31 October 1999. We designed our program to evaluate fish cultural practices, conduct rearing and survival studies, assess sport fisheries, and provide information for planning and coordination. Additional studies have been designed for fall chinook salmon to evaluate straying and the effects of tagging. We monitored the culture and performance of more than 3.2 million chinook salmon and steelhead produced at UFH in 1997-98 (Appendix Tables A1-8). Individual stock profiles, release, performance, and return data of previously released groups are presented in the following sections.« less

Pollution ecology of breeding great blue herons in the Columbia Basin, Oregon and Washington

USGS Publications Warehouse

Blus, L.J.; Henny, C.J.; Kaiser, T.E.

1980-01-01

Approximately 40 pairs of Great Blue Herons (Ardea herodias) formerly nested in trees on or near Blalock Island about 95 km downstream from Richland, Washington, in the Columbia River (Nehls 1972 ). In conjunction with construction of the John Day Lock and Dam and before creating Lake Umatilla in 1968, large trees along the shoreline, including those in the heronry on Blalock Island, were removed except for about six cottonwood trees (Populus sp.) that were left standing near the south bank of the river (David Lenhart, pers. comm.). As a mitigation procedure, the Umatilla National Wildlife Refuge (Umatilla) was established in 1967. The herons subsequently established a secondary heronry in the six cottonwoods; 20 pairs were present in 1971 (Nehls 1972). The inundated trees died and deteriorated; only two trees with eight nests remained in 1976 (Henny and Kurtz 1978), and we found just two nests in one tree in 1978. With a decrease in traditional nesting sites, the birds nested on islands in big sagebrush (Artemisia tridentata), on channel markers in the Columbia River, and on nesting platforms constructed for Canada Geese (Branta canadensis). The purpose of this paper is to describe the breeding biology of Great Blue Herons at Umatilla and the McNary Recreation Area (McNary) in 1978 and the relationship of organochlorine residues in eggs to eggshell thickness and reproductive success. The primary reason for conducting this study was to determine if the heptachlor seed treatment that was severely affecting Canada Geese at Umatilla (Blus et al. 1979) was also a hazard to Great Blue Herons. At the same time we also investigated possible effects of other organochlorines on the herons.

Uncertainty-Based Multi-Objective Optimization of Groundwater Remediation Design

NASA Astrophysics Data System (ADS)

Singh, A.; Minsker, B.

2003-12-01

Management of groundwater contamination is a cost-intensive undertaking filled with conflicting objectives and substantial uncertainty. A critical source of this uncertainty in groundwater remediation design problems comes from the hydraulic conductivity values for the aquifer, upon which the prediction of flow and transport of contaminants are dependent. For a remediation solution to be reliable in practice it is important that it is robust over the potential error in the model predictions. This work focuses on incorporating such uncertainty within a multi-objective optimization framework, to get reliable as well as Pareto optimal solutions. Previous research has shown that small amounts of sampling within a single-objective genetic algorithm can produce highly reliable solutions. However with multiple objectives the noise can interfere with the basic operations of a multi-objective solver, such as determining non-domination of individuals, diversity preservation, and elitism. This work proposes several approaches to improve the performance of noisy multi-objective solvers. These include a simple averaging approach, taking samples across the population (which we call extended averaging), and a stochastic optimization approach. All the approaches are tested on standard multi-objective benchmark problems and a hypothetical groundwater remediation case-study; the best-performing approach is then tested on a field-scale case at Umatilla Army Depot.

5 CFR 532.285 - Special wage schedules for supervisors of negotiated rate Bureau of Reclamation employees.

Code of Federal Regulations, 2012 CFR

2012-01-01

... industry titles 211 Oil and gas extraction. 212 Mining (except oil and gas). 213 Support activities for..., Bend, Medford, Umatilla, Multnomah Utah: Salt Lake Idaho: Ada, Canyon, Adams Washington: Spokane, Grant..., Platte, Niobrara, Converse, Natrona, Fremont, Sublette, Lincoln Utah: Beaver, Box Elder, Cache, Carbon...

5 CFR 532.285 - Special wage schedules for supervisors of negotiated rate Bureau of Reclamation employees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... industry titles 211 Oil and gas extraction. 212 Mining (except oil and gas). 213 Support activities for..., Bend, Medford, Umatilla, Multnomah Utah: Salt Lake Idaho: Ada, Canyon, Adams Washington: Spokane, Grant..., Platte, Niobrara, Converse, Natrona, Fremont, Sublette, Lincoln Utah: Beaver, Box Elder, Cache, Carbon...

5 CFR 532.285 - Special wage schedules for supervisors of negotiated rate Bureau of Reclamation employees.

Code of Federal Regulations, 2011 CFR

2011-01-01

... industry titles 211 Oil and gas extraction. 212 Mining (except oil and gas). 213 Support activities for..., Bend, Medford, Umatilla, Multnomah Utah: Salt Lake Idaho: Ada, Canyon, Adams Washington: Spokane, Grant..., Platte, Niobrara, Converse, Natrona, Fremont, Sublette, Lincoln Utah: Beaver, Box Elder, Cache, Carbon...

5 CFR 532.285 - Special wage schedules for supervisors of negotiated rate Bureau of Reclamation employees.

Code of Federal Regulations, 2013 CFR

2013-01-01

... industry titles 211 Oil and gas extraction. 212 Mining (except oil and gas). 213 Support activities for..., Bend, Medford, Umatilla, Multnomah Utah: Salt Lake Idaho: Ada, Canyon, Adams Washington: Spokane, Grant..., Platte, Niobrara, Converse, Natrona, Fremont, Sublette, Lincoln Utah: Beaver, Box Elder, Cache, Carbon...

5 CFR 532.285 - Special wage schedules for supervisors of negotiated rate Bureau of Reclamation employees.

Code of Federal Regulations, 2014 CFR

2014-01-01

... industry titles 211 Oil and gas extraction. 212 Mining (except oil and gas). 213 Support activities for..., Bend, Medford, Umatilla, Multnomah Utah: Salt Lake Idaho: Ada, Canyon, Adams Washington: Spokane, Grant..., Platte, Niobrara, Converse, Natrona, Fremont, Sublette, Lincoln Utah: Beaver, Box Elder, Cache, Carbon...

Mapping of human brown adipose tissue in lean and obese young men

PubMed Central

Leitner, Brooks P.; Huang, Shan; Brychta, Robert J.; Duckworth, Courtney J.; Baskin, Alison S.; McGehee, Suzanne; Tal, Ilan; Dieckmann, William; Gupta, Garima; Kolodny, Gerald M.; Pacak, Karel; Herscovitch, Peter

2017-01-01

Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy expenditure, making it a potential target for treating obesity and metabolic disease. Data on the functional and anatomic characteristics of BAT are limited, however. In 20 healthy young men [12 lean, mean body mass index (BMI) 23.2 ± 1.9 kg/m2; 8 obese, BMI 34.8 ± 3.3 kg/m2] after 5 h of tolerable cold exposure, we measured BAT volume and activity by 18F-labeled fluorodeoxyglucose positron emission tomography/computerized tomography (PET/CT). Obese men had less activated BAT than lean men (mean, 130 vs. 334 mL) but more fat in BAT-containing depots (mean, 1,646 vs. 855 mL) with a wide range (0.1–71%) in the ratio of activated BAT to inactive fat between individuals. Six anatomic regions had activated BAT—cervical, supraclavicular, axillary, mediastinal, paraspinal, and abdominal—with 67 ± 20% of all activated BAT concentrated in a continuous fascial layer comprising the first three depots in the upper torso. These nonsubcutaneous fat depots amounted to 1.5% of total body mass (4.3% of total fat mass), and up to 90% of each depot could be activated BAT. The amount and activity of BAT was significantly influenced by region of interest selection methods, PET threshold criteria, and PET resolutions. The present study suggests that active BAT can be found in specific adipose depots in adult humans, but less than one-half of the fat in these depots is stimulated by acute cold exposure, demonstrating a previously underappreciated thermogenic potential. PMID:28739898

Decline in bone mineral density with stress fractures in a woman on depot medroxyprogesterone acetate. A case report.

PubMed

Harkins, G J; Davis, G D; Dettori, J; Hibbert, M L; Hoyt, R A

1999-03-01

Depot medroxyprogesterone acetate is a popular contraceptive among young, physically active women. However, its administration has been linked to a relative decrease in estrogen levels. Since bone resorption is accelerated during hypoestrogenic states, there has been growing concern about the potential development of osteoporosis and fractures with the use of this contraceptive method. A physically active, 33-year-old woman demonstrated a 12.4% drop in femoral neck bone mineral density (BMD), 6.4% drop in lumbar BMD and 0.8% drop in total BMD with the subsequent development of a tibial stress fracture while on depot medroxyprogesterone acetate. Bone mineralization rapidly improved, and the stress fracture resolved with discontinuation of the medication. The long-term effects of depot medroxyprogesterone acetate on bone mineralization in physically active women should be evaluated more thoroughly.

Umatilla River Basin Anadromus Fish Habitat Enhancement Project : 1994 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaw, R. Todd

1994-05-01

The Umatilla Basin Anadromous Fish Habitat Enhancement Project is funded under the Northwest Power Planning Council's Columbia River Basin Fish and Wildlife Program, Section 7.6-7.8 and targets the improvement of water quality and restoration of riparian areas, holding, spawning and rearing habitats of steelhead, spring and fall chinook and coho salmon. The project focused on implementing cooperative instream and riparian habitat improvements on private lands on the Umatilla Indian Reservation (hereafter referred to as Reservation) from April 1, 1988 to March 31, 1992. These efforts resulted in enhancement of the lower l/4 mile of Boston Canyon Creek, the lower 4more » river miles of Meacham Creek and 3.2 river miles of the Umatilla River in the vicinity of Gibbon, Oregon. In 1993, the project shifted emphasis to a comprehensive watershed approach, consistent with other basin efforts, and began to identify upland and riparian watershed-wide causative factors impacting fisheries habitat and natural fisheries production capabilities throughout the Umatilla River Watershed. During the 1994-95 project period, a one river mile demonstration project was implemented on two privately owned properties on Wildhorse Creek. This was the first watershed improvement project to be implemented by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) off of the Reservation. Four 15 year riparian easements and two right-of-way agreements were secured for enhancement of one river mile on Wildhorse Creek and l/2 river mile on Meacham Creek. Enhancements implemented between river mile (RM) 9.5 and RM 10.5 Wildhorse Creek included: (1) installation of 1.43 miles of smooth wire high tensile fence line and placement of 0.43 miles of fence posts and structures to restrict livestock from the riparian corridor, (2) construction of eighteen sediment retention structures in the stream channel to speed riparian recovery by elevating the stream grade, slowing water velocities and depositing sediments onto streambanks to provide substrate for revegetation, and (3) revegetation of the stream corridor, terraces and adjacent pasture areas with 644 pounds of native grass seed (when commercially available) or close species equivalents and 4,000 native riparian shrub/tree species to assist in floodplain recovery, stream channel stability and filtering of sediments during high flow periods. Three hundred pounds of native grass/legume seed (including other grasses/legumes exhibiting native species characteristics) were broadcast in existing Boston Canyon Creek, Meacham Creek and Umatilla River project areas. The addition of two properties into the project area between RM 4.25 and RM 4.75 Meacham Creek during the 1995-96 work period will provide nearly complete project coverage of lower Meacham Creek corridor areas on the Reservation. Water quality monitoring continued for temperature and turbidity throughout the upper Umatilla River Watershed. Survey of cross sections and photo documentation of riparian recovery within the project areas provided additional baseline data. Physical habitat surveys continued to be conducted to characterize habitat quality and to quantify various habitat types by area. This information will be utilized to assist in identification of habitat deficient areas within the watershed in which to focus habitat restoration efforts. These efforts were coordinated with the CTUIR Umatilla Basin Natural Production Monitoring and Evaluation (UBNPME) Project. Poor land use practices, which have altered natural floodplain dynamics and significantly reduced or eliminated fisheries habitat, continued to be identified in the Mission Creek Subbasin. Complied data is currently being incorporated into a data layer for a Geographic Information System (GIS) data base. This effort is being coordinated with the Natural Resource Conservation Service (NRCS). Community outreach efforts and public education opportunities continued during the reporting period. CTUIR cooperatively sponsored a bioengineering workshop on February 23, 1995 with the Oregon Department of Fish and Wildlife (ODFW). This workshop attracted a combined total 3f over 270 participants at day and evening sessions.« less

77 FR 47592 - Umatilla National Forest, Columbia County Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

...The Umatilla National Forest, Columbia County Resource Advisory Committee will meet in Dayton, Washington as authorized under the Secure Rural Schools and Community Self-Determination Act. Purpose of the meeting will be to monitor projects being implemented under Public Law 110-343 and if authorized by the Secretary of Agriculture by the meeting date, to review and recommend projects to be funded under Public Law 112-141. This meeting is open to the public.

Preparation and in vitro characterization of SN-38-loaded, self-forming polymeric depots as an injectable drug delivery system.

PubMed

Manaspon, Chawan; Hongeng, Suradej; Boongird, Atthaporn; Nasongkla, Norased

2012-10-01

This work describes the preparation and characterization of anticancer-loaded injectable polymeric depots that consisted of D,L-lactide (LA), ε-caprolactone (CL), and poly(ethylene glycol) (PEG) or [poly(ε-caprolactone)-random-poly(D,L-lactide)]-block-poly(ethylene glycol)-block-[poly(ε-caprolactone)-random-poly(D,L-lactide)] (PLEC) copolymers for malignant gliomas treatment. PLECs were polymerized with different percentages of LA to deliver 7-ethyl-10-hydroxycamptothecin (SN-38), a highly potent anticancer drug. SN-38-loaded depots could form directly in phosphate buffer saline with more than 98% encapsulation efficiency. The release rate of SN-38 from depots was found to depend on the amount of LA in PLECs, loading content of SN-38 in the depots, and depot weight. Encapsulation of SN-38 inside depots could enhance the stability of SN-38 where all of SN-38 released after 60 days was in an active form. Depots without SN-38 were evaluated as noncytotoxic against U-87MG, whereas SN-38-loaded depots showed cytotoxic effect as a function of concentration. Copyright © 2012 Wiley Periodicals, Inc.

77 FR 47593 - Umatilla National Forest, Southeast Washington Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

...The Umatilla National Forest, Southeast Washington Resource Advisory Committee will meet in Pomeroy, Washington as authorized under the Secure Rural Schools and Community Self-Determination Act, as amended, in compliance with the Federal Advisory Committee Act. Purpose of the meeting will be to monitor projects being implemented under Public Law 110-343 and if authorized by the Secretary of Agriculture by the meeting date, to review and recommend projects to be funded under Public Law 112-141. This meeting is open to the public.

76 FR 5392 - Agency Information Collection Activities: Proposed Collection; Comment Request, OMB No. 1660-0057...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-31

... Survey; FEMA Form 008-0-6, Umatilla EPZ Residential Survey; FEMA Form 008-0-7, Blue Grass EPZ Residential... Grass EPZ Residential Survey; FEMA Form 008-0-8, Deseret EPZ Residential Survey. Abstract: To support... households Blue Grass EPZ 822 1 822 0.25 (15 205.5 Residential Survey/FEMA minutes) Form 008-0-7. Individuals...

Salmon restoration in the Umatilla River: A study of straying and risk containment

USGS Publications Warehouse

Hayes, M.C.; Carmichael, R.W.

2002-01-01

The use of artificial propagation may produce unexpected results and the need for risk containment. Stray chinook salmon (Oncorhynchus tshawytscha) from Umatilla River releases put the threatened Snake River stock at risk, caused conflict between two plans, altered management, and greatly increased the costs for hatchery-based restoration. Stray Umatilla returns captured or observed in the Snake River averaged more than 200 fish annually and comprised up to 26% of the escapement. The risk to the threatened population stimulated a series of containment actions, including wire tagging 2-3 million fish annually, use of acclimation ponds, altering release locations, flow enhancement, and broodstock management changes. Actions for the use of artificial propagation where straying or unexpected results are a concern include marking or tagging most or all fish, limiting the number of fish initially released, recognizing environmental variables that influence straying, ensuring that funding for risk containment is available when undesirable results occur, and recognizing that unexpected results may not be manifested or identified immediately.

Biodegradation of insensitive munition formulations IMX101 and IMX104 in surface soils.

PubMed

Indest, Karl J; Hancock, Dawn E; Crocker, Fiona H; Eberly, Jed O; Jung, Carina M; Blakeney, Gary A; Brame, Jon; Chappell, Mark A

2017-07-01

The biodegradation potential of insensitive munition melt cast formulations IMX101 and IMX104 was investigated in two unamended training range soils under aerobic and anaerobic growth conditions. Changes in community profiles in soil microcosms were monitored via high-throughput 16S rRNA sequencing over the course of the experiments to infer key microbial phylotypes that may be linked to IMX degradation. Complete anaerobic biotransformation occurred for IMX101 and IMX104 constituents 2,4-dinitroanisole (DNAN) and 3-nitro-1,2,4-triazol-5-one during the 30-day incubation period with Camp Shelby (CS) soil. By comparison, soil from Umatilla chemical depot demonstrated incomplete DNAN degradation with reduced transformation rates for both IMX101 and IMX104. Aerobic soil microcosms for both soils demonstrated reduced transformation rates compared to anaerobic degradation for all IMX constituents with DNAN the most susceptible to biotransformation by CS soil. Overall, IMX constituents hexahydro-1,3,5-trinitro-1,3,5-triazine and 1-nitroguanidine did not undergo significant transformation. In CS soil, organisms that have been associated with explosives degradation, namely members of the Burkholderiaceae, Bacillaceae, and Paenibacillaceae phylotypes increased significantly in anaerobic treatments whereas Sphingomonadaceae increased significantly in aerobic treatments. Collectively, these data may be used to populate fate and transport models to provide more accurate estimates for assessing environmental costs associated with release of IMX101 and IMX104.

Injectable SN-38-loaded Polymeric Depots for Cancer Chemotherapy of Glioblastoma Multiforme.

PubMed

Manaspon, Chawan; Nasongkla, Norased; Chaimongkolnukul, Khuanjit; Nittayacharn, Pinunta; Vejjasilpa, Ketpat; Kengkoom, Kanchana; Boongird, Atthaporn; Hongeng, Suradej

2016-12-01

SN-38, a potent chemotherapeutic drug, has not been used clinically because of its severe side effects and poor solubility. In this work, we aimed to evaluate the effect of dose and multiple injections of SN-38-loaded polymeric depots on antitumor efficacy and toxicity in vivo. Preparation and characterization of SN-38-loaded depots were performed and evaluated in vitro using human glioblastoma cell line, U-87MG. Antitumor efficacy with different depot administrations including dose, position of depot injection and number of injections were evaluated in tumor model in nude mice. Depots encapsulated SN-38 with high encapsulation efficiency (~98.3%). High amount of SN-38 (3.0 ± 0.1 mg) was prolonged and controlled release over time and showed anticancer activity against U-87MG cell line in vitro. For one course administration, depots exhibited better antitumor efficacy and reduced toxicity compared to free SN-38. Elevated doses and multiple injections of SN-38-loaded depots and free SN-38 provided greater tumor growth inhibition and animal survival. All animals received SN-38-loaded depots were well tolerated and survived while most of those received free SN-38 died at day 30. Free SN-38 showed severe toxic effect compared to minimal toxicity from SN-38-loaded depots which was due to lower SN-38 level in systemic circulation. Fluorescence imaging and histopathology confirmed that SN-38 released from depots was detected throughout tumors 35 days post administration. SN-38-loaded depots were proved as a promising new treatment for highly invasive glioblastoma multiforme with low acute toxicity due to controlled release of SN-38.

Examination of adipose depot-specific PPAR moieties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dodson, M.V., E-mail: dodson@wsu.edu; Vierck, J.L.; Hausman, G.J.

2010-04-02

Molecular mechanisms of peroxisome proliferator activated receptors (PPARs) are being defined rapidly, as illustrated by the volume of papers published. Much of the research is directed towards a clinical end-point/application; however, the non-homogeneous nature of adipose depots in laboratory animals is spurring similar research in domestic meat animals (such as beef cattle). Moreover, the size of adipose depots in meat animals remains an attractive feature for using them to obtain cells for PPAR research. Examination of meat-animal depot-specific PPAR moieties may provide novel information about adipocyte regulation that might be extrapolated to all animals.

Male Bovine GH Transgenic Mice Have Decreased Adiposity With an Adipose Depot-Specific Increase in Immune Cell Populations

PubMed Central

Benencia, Fabian; Harshman, Stephanie; Duran-Ortiz, Silvana; Lubbers, Ellen R.; List, Edward O.; Householder, Lara; Al-Naeeli, Mawadda; Liang, Xiaoyu; Welch, Lonnie; Kopchick, John J.

2015-01-01

White adipose tissue (WAT) is composed of mature adipocytes and a stromal vascular fraction (SVF), which contains a variety of cells, including immune cells that vary among the different WAT depots. Growth hormone (GH) impacts immune function and adiposity in an adipose depot-specific manner. However, its effects on WAT immune cell populations remain unstudied. Bovine GH transgenic (bGH) mice are commonly used to study the in vivo effects of GH. These giant mice have an excess of GH action, impaired glucose metabolism, decreased adiposity, increased lean mass, and a shortened lifespan. Therefore, the purpose of this study was to characterize the WAT depot-specific differences in immune cell populations in the presence of excess GH in vivo. Three WAT depots were assessed: inguinal (sc), epididymal (EPI), and mesenteric (MES). Subcutaneous and MES bGH WAT depots showed a significantly higher number of total SVF cells, yet only MES bGH WAT had higher leukocyte counts compared with control samples. By means of flow cytometry analysis of the SVF, we detected greater macrophage and regulatory T-cell infiltration in sc and MES bGH WAT depots compared with controls. However, no differences were observed in the EPI WAT depot. RNA-sequencing confirmed significant alterations in pathways related to T-cell infiltration and activation in the sc depot with fewer significant changes in the EPI bGH WAT depot. These findings collectively point to a previously unrecognized role for GH in influencing the distribution of WAT immune cell populations in a depot-specific manner. PMID:25521584

Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.

PubMed

Benencia, Fabian; Harshman, Stephanie; Duran-Ortiz, Silvana; Lubbers, Ellen R; List, Edward O; Householder, Lara; Al-Naeeli, Mawadda; Liang, Xiaoyu; Welch, Lonnie; Kopchick, John J; Berryman, Darlene E

2015-05-01

White adipose tissue (WAT) is composed of mature adipocytes and a stromal vascular fraction (SVF), which contains a variety of cells, including immune cells that vary among the different WAT depots. Growth hormone (GH) impacts immune function and adiposity in an adipose depot-specific manner. However, its effects on WAT immune cell populations remain unstudied. Bovine GH transgenic (bGH) mice are commonly used to study the in vivo effects of GH. These giant mice have an excess of GH action, impaired glucose metabolism, decreased adiposity, increased lean mass, and a shortened lifespan. Therefore, the purpose of this study was to characterize the WAT depot-specific differences in immune cell populations in the presence of excess GH in vivo. Three WAT depots were assessed: inguinal (sc), epididymal (EPI), and mesenteric (MES). Subcutaneous and MES bGH WAT depots showed a significantly higher number of total SVF cells, yet only MES bGH WAT had higher leukocyte counts compared with control samples. By means of flow cytometry analysis of the SVF, we detected greater macrophage and regulatory T-cell infiltration in sc and MES bGH WAT depots compared with controls. However, no differences were observed in the EPI WAT depot. RNA-sequencing confirmed significant alterations in pathways related to T-cell infiltration and activation in the sc depot with fewer significant changes in the EPI bGH WAT depot. These findings collectively point to a previously unrecognized role for GH in influencing the distribution of WAT immune cell populations in a depot-specific manner.

DoD Security Assistance Management Manual

DTIC Science & Technology

1988-10-01

IDSS Administrator for U.S. Army Training Activities: TSASS Database Manager SATFA Attn: ATFA-I 2017 Cunningham Drive, 4th Floor Hampton VA 23666 DSN...Depot, Chambersburg, PA J. School of Engineering and Logistics, Red River Army Depot, Texarkana , "TX K. Lone Star Ammunition Plant, Texarkana , TX L...Electronics Command, Ft. Monmouth, NJ U. Red River Army Depot, Texarkana , TX V. Army Aviation Research and Development Command, St. Louis, MO W

Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men.

PubMed Central

Fried, S K; Russell, C D; Grauso, N L; Brolin, R E

1993-01-01

There are marked variations in the activity of lipoprotein lipase (LPL) among adipose depots, particularly in women. Consistent with data on LPL activity, the level of expression of LPL mRNA was lower in omental (OM) than subcutaneous (SQ) adipose tissue of women. To investigate the cellular basis of these differences, OM and SQ adipose tissues obtained at surgery from obese men and women were placed in organ culture for 7 d with varying concentrations of insulin and dexamethasone. Insulin increased levels of LPL mRNA and LPL activity in abdominal SQ but not OM adipose tissue. Dexamethasone also increased LPL mRNA and LPL activity, and these effects were more marked in the OM adipose tissue, particularly in men. When insulin and dexamethasone were added together, synergistic increases in LPL activity were seen in both depots, and this was in part explained at the level of LPL mRNA. The SQ depot was more sensitive to the effects of submaximal doses of dexamethasone in the presence of insulin. The maximum activity of LPL induced by insulin or insulin plus dexamethasone was higher in the SQ than in the OM depot of women, and this was associated with higher levels of LPL mRNA. Rates of LPL synthesis paralleled LPL mRNA levels. These data show that insulin and glucocorticoids influence human adipose tissue LPL activity at the level of LPL gene expression, as well as posttranslationally, and that responsiveness to these hormonal effects is dependent on adipose depot and gender. Images PMID:8227334

Accumulation of radionuclides in bed sediments of the Columbia River between Hanford reactors and McNary Dam

USGS Publications Warehouse

Nelson, Jack L.; Haushild, W.L.

1970-01-01

Amounts of radionuclides from the Hanford reactors contained in bed sediments of the Columbia River were estimated by two methods: (1) from data on radionuclide concentration for the bed sediments between the reactors and McNary Dam, and (2) from data on radionuclide discharge for river stations at Pasco, Washington, and Umatilla, Oregon. Umatilla is 3.2 kilometers below McNary Dam. Accumulations of radionuclides in the Pasco to Umatilla reach estimated by the two methods agree within about 8%. In October 1965 approximately 16,000 curies of gamma emitting radionuclides were resident in bed sediments of the river between the Hanford reactors and McNary Dam. Concentrations and accumulations of chromium-51, zinc-65, cobalt-60, manganese-54, and scandium-46 generally are much higher near McNary Dam than they are in the vicinity of the reactors. These changes are caused by an increase downstream from the reactors in the proportion of the bed sediment that is fine grained and the proportions of the transported zinc, cobalt, manganese, and scandium radionuclides associated with sediment particles.

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma.

PubMed

Vergnes, Laurent; Davies, Graeme R; Lin, Jason Y; Yeh, Michael W; Livhits, Masha J; Harari, Avital; Symonds, Michael E; Sacks, Harold S; Reue, Karen

2016-11-01

Patients with pheochromocytoma (pheo) show presence of multilocular adipocytes that express uncoupling protein 1 within periadrenal (pADR) and omental (OME) fat depots. It has been hypothesized that this is due to adrenergic stimulation by catecholamines produced by the pheo tumors. To characterize the prevalence and respiratory activity of brown-like adipocytes within pADR, OME, and SC fat depots in human adult pheo patients. This was an observational cohort study. The study took place in a university hospital. We studied 46 patients who underwent surgery for benign adrenal tumors (21 pheos and 25 controls with adrenocortical adenomas). We characterized adipocyte browning in pADR, SC, and OME fat depots for histological and immunohistological features, mitochondrial respiration rate, and gene expression. We also determined circulating levels of catecholamines and other browning-related hormones. Eleven of 21 pheo pADR adipose samples, but only one of 25 pADR samples from control patients exhibited multilocular adipocytes. The pADR browning phenotype was associated with higher plasma catecholamines and raised uncoupling protein 1. Mitochondria from multilocular pADR fat of pheo patients exhibited increased rates of coupled and uncoupled respiration. Global gene expression analysis in pADR fat revealed enrichment in β-oxidation genes in pheo patients with multilocular adipocytes. No SC or OME fat depots exhibited aspects of browning. Browning of the pADR depot occurred in half of pheo patients and was associated with increased catecholamines and mitochondrial activity. No browning was detected in other fat depots, suggesting that other factors are required to promote browning in these depots.

Inpatient treatment of rheumatoid arthritis with synacthen depot: a double blind placebo controlled trial with 6 month followup.

PubMed

Taylor, W J; Rajapakse, C N; Harris, K A; Harrison, A A; Corkill, M M

1999-12-01

To assess the additional benefit of synacthen depot over standard inpatient care for patients hospitalized with active rheumatoid arthritis (RA). All patients admitted to our unit with active RA without exclusion criteria were invited to participate and randomized to subcutaneous synacthen depot 0.5 mg on alternate days for 2 injections or 2 injections of saline. Patients, staff, and assessors of response were blinded to the intervention. Assessment [OMERACT set, American College of Rheumatology (ACR) global improvement, dose of intraarticular (IA) or intramuscular (IM) methylprednisolone] was performed at admission to hospital, at discharge, and at 3 and 6 months. Oral prednisone use constituted a protocol violation. Of 137 patients with RA admitted over the period of recruitment, 36 (26%) were enrolled; 31 completed followup. There were no between-group differences in the change from admission of any individual disease activity measure at any time point. However, using a rigorous global response measure (ACR 50%), a difference was detected in favor of synacthen depot at discharge (52.6% of the intervention group improved vs. 17.6% of controls; p = 0.029, number-needed-to-treat 2.86). Patients treated with synacthen depot showed a trend toward more IA or IM corticosteroid between discharge and 3 months (mean dose 56 vs. 31 mg; p = 0.19) and a trend toward more patients requiring a change in slow acting antirheumatic drug after discharge (4 vs. 1; p = 0.27). There is some additional benefit of synacthen depot in the hospital treatment of RA, but the effect is lost by 3 months, with a suggestion of rebound worsening in these patients. We postulate that oversuppression of corticotrophin releasing hormone by exogenous adrenocorticotrophic hormone in patients who already have a hypothalamic deficit may contribute to the rebound worsening of disease activity seen in these patients.

Umatilla River Fish Passage Operations Program, 2003-2004 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bronson, James P.; Duke, Bill B.

2005-08-01

Threemile Falls Dam (Threemile Dam), located near the town of Umatilla, is the major collection and counting point for adult salmonids returning to the Umatilla River. Returning salmon and steelhead were enumerated at Threemile Dam from August 19, 2003 to July 8, 2004. A total of 3,388 summer steelhead (Oncorhynchus mykiss); 1,482 adult, 638 jack, and 2,150 subjack fall chinook (O. tshawytscha); 8,319 adult and 667 jack coho (O. kisutch); and 2,965 adult and 270 jack spring chinook (O. tshawytscha) were counted. All fish were enumerated at the east bank facility. Of the fish counted, 34 summer steelhead and 31more » adult and 9 jack spring chinook were hauled upstream from Threemile Dam. There were 3,166 summer steelhead; 1,076 adult, 554 jack and 2,026 subjack fall chinook; 8,213 adult and 647 jack coho; and 2,152 adult and 174 jack spring chinook either released at, or allowed to volitionally migrate past, Threemile Dam. Also, 121 summer steelhead; 388 adult and 19 jack fall chinook; and 561 adult and 29 jack spring chinook were collected for brood. In addition, 239 spring chinook were collected for the outplanting efforts in the Walla Walla Basin. There were also 25 pair hatchery steelhead adults collected for the progeny maker study. The Westland Canal juvenile facility (Westland), located near the town of Echo at rivermile (RM) 27, is the major collection point for outmigrating juvenile salmonids and steelhead kelts. The canal was open for 184 days between January 12 and July 6, 2004. During that period, fish were bypassed back to the river 173 days and were trapped 10 days. An estimated 44 pounds of juvenile fish were transported from Westland to the Umatilla River boat ramp (RM 0.5). Approximately 84% of the juveniles transported were salmonids. No steelhead kelts were hauled from Westland this year. The Threemile Dam west bank juvenile bypass was opened on February 10, 2004 for outmigration sampling and continued until July 7, 2004 when sampling was discontinued. The juvenile bypass ran at the 5 cfs level until the initiation of Phase I on August 15, 2004. The juvenile trap was operated by the Oregon Department of Fish and Wildlife (ODFW) under the Evaluation of Umatilla Juvenile Salmonid Outmigration Project.« less

Clay Nanoparticles Elicit Long-Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation.

PubMed

Chen, Weiyu; Zuo, Huali; Li, Bei; Duan, Chengcheng; Rolfe, Barbara; Zhang, Bing; Mahony, Timothy J; Xu, Zhi Ping

2018-05-01

Nanomaterials have been widely tested as new generation vaccine adjuvants, but few evoke efficient immunoreactions. Clay nanoparticles, for example, layered double hydroxide (LDH) and hectorite (HEC) nanoparticles, have shown their potent adjuvanticity in generating effective and durable immune responses. However, the mechanism by which clay nanoadjuvants stimulate the immune system is not well understood. Here, it is demonstrated that LDH and HEC-antigen complexes form loose agglomerates in culture medium/serum. They also form nodules with loose structures in tissue after subcutaneous injection, where they act as a depot for up to 35 d. More importantly, clay nanoparticles actively and continuously recruit immune cells into the depot for up to one month, and stimulate stronger immune responses than FDA-approved adjuvants, Alum and QuilA. Sustained antigen release is also observed in clay nanoparticle depots, with 50-60% antigen released after 35 d. In contrast, Alum-antigen complexes show minimal antigen release from the depot. Importantly, LDH and HEC are more effective than QuilA and Alum in promoting memory T-cell proliferation. These findings suggest that both clay nanoadjuvants can serve as active vaccine platforms for sustained and potent immune responses. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Environmental Monitoring of Transportation of 30MM Ammunition in MILVANS from Savanna Army Depot Activity (SVDA) to Crane Army Ammunition Activity (CAAA) via Highway and Rail.

DTIC Science & Technology

1997-07-01

from Savanna Army Depot Activity (SVDA) to Crane Army Ammunition Activity (CAAA). The first instrumented MIL VAN was transported on a flatbed ...SLACK CAN BE ELIMINATED FROM A LOAD BAY BY LAMINATING ADDITIONAL BEARING PIECES OF APPROPRIATE THICKNESS TO THE BEARING PIECES OF ONE OR MORE SIDE...FILL GATES ON ONE OR BOTH SIDES OF THE CONTAINER. FIVE (5) NAILS OF APPROPRIATE SIZE WILL BE USED TO LAMINATE EACH ADDED BEARING PIECE. F

Echo Meadows Project Winter Artificial Recharge.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziari, Fred

2002-12-19

This report discusses the findings of the Echo Meadows Project (BPA Project 2001-015-00). The main purpose of this project is to artificially recharge an alluvial aquifer, WITH water from Umatilla River during the winter high flow period. In turn, this recharged aquifer will discharge an increased flow of cool groundwater back to the river, thereby improving Umatilla River water quality and temperature. A considerable side benefit is that the Umatilla River should improve as a habitat for migration, spanning, and rearing of anadromous and resident fish. The scope of this project is to provide critical baseline information about the Echomore » Meadows and the associated reach of the Umatilla River. Key elements of information that has been gathered include: (1) Annual and seasonal groundwater levels in the aquifer with an emphasis on the irrigation season, (2) Groundwater hydraulic properties, particularly hydraulic conductivity and specific yield, and (3) Groundwater and Umatilla River water quality including temperature, nutrients and other indicator parameters. One of the major purposes of this data gathering was to develop input to a groundwater model of the area. The purpose of the model is to estimate our ability to recharge this aquifer using water that is only available outside of the irrigation season (December through the end of February) and to estimate the timing of groundwater return flow back to the river. We have found through the data collection and modeling efforts that this reach of the river had historically returned as much as 45 cubic feet per second (cfs) of water to the Umatilla River during the summer and early fall. However, this return flow was reduced to as low as 10 cfs primarily due to reduced quantities of irrigation application, gain in irrigation efficiencies and increased groundwater pumping. Our modeling indicated that it is possible to restore these critical return flows using applied water outside of the irrigation season. We further found that this water can be timed to return to the river during the desired time of the year (summer to early fall). This is because the river stage, which remains relatively high until this time, drops during the irrigation season-thereby releasing the stored groundwater and increasing river flows. A significant side benefit is that these enhanced groundwater return flows will be clean and cold, particularly as compared to the Umatilla River. We also believe that this same type of application of water could be done and the resulting stream flows could be realized in other watersheds throughout the Pacific Northwest. This means that it is critical to compare the results from this baseline report to the full implementation of the project in the next phase. As previously stated, this report only discusses the results of data gathered during the baseline phase of this project. We have attempted to make the data that has been gathered accessible with the enclosed databases and spreadsheets. We provide computer links in this report to the databases so that interested parties can fully evaluate the data that has been gathered. However, we cannot emphasize too strongly that the real value of this project is to implement the phases to come, compare the results of these future phases to this baseline and develop the science and strategies to successfully implement this concept to other rivers in the Pacific Northwest. The results from our verified and calibrated groundwater model matches the observed groundwater data and trends collected during the baseline phase. The modeling results indicate that the return flows may increase to their historic values with the addition of 1 acre-ft/acre of recharge water to the groundwater system (about 9,600 acre-feet total). What this means is that through continued recharge project, you can double to quadruple the annual baseflow of the Umatilla River during the low summer and fall flow periods as compared to the present base-flow. The cool and high quality recharge water is a significant beneficial impact to the river system.« less

77 FR 30376 - Amendment of Restricted Area R-2101; Anniston Army Depot, AL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

...-0510; Airspace Docket No. 12-ASO-17] RIN 2120-AA66 Amendment of Restricted Area R-2101; Anniston Army... amends the description of restricted area R-2101, Anniston Army Depot, AL, by removing the abbreviation.... This amendment does not change the dimensions of, or activities conducted within, R-2101. DATES...

Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period.

PubMed

De Koster, J; Van den Broeck, W; Hulpio, L; Claeys, E; Van Eetvelde, M; Hermans, K; Hostens, M; Fievez, V; Opsomer, G

2016-03-01

The aim of the present research was to describe characteristics of adipose tissue lipolysis in dairy cows with a variable body condition score (BCS). Ten clinically healthy Holstein Friesian cows were selected based on BCS and euthanized 10 to 13 d before the expected parturition date. Immediately after euthanasia, adipose tissue samples were collected from subcutaneous and omental fat depots. In both depots, we observed an increase in adipocyte size with increasing BCS. Using an in vitro explant culture of subcutaneous and omental adipose tissue, we aimed to determine the influence of adipocyte size and localization of adipose depot on the lipolytic activity in basal conditions and after addition of isoproterenol (nonselective β-agonist) and insulin in different concentrations. Glycerol release in the medium was used as a measure for lipolytic activity. We observed that the basal lipolytic activity of subcutaneous and omental adipose tissue increased with adipocyte volume, meaning that larger fat cells have higher basal lipolytic activity independent of the location of the adipose depot. Dose-response curves were created between the concentration of isoproterenol or insulin and the amount of glycerol released. The shape of the dose-response curves is determined by the concentration of isoproterenol and insulin needed to elicit the half-maximal effect and the maximal amount of stimulated glycerol release or the maximal inhibitory effect of insulin. We observed that larger fat cells released more glycerol upon maximal stimulation with isoproterenol and this was more pronounced in subcutaneous adipose tissue. Additionally, larger fat cells had a higher sensitivity toward lipolytic signals. We observed a trend for larger adipocytes to be more resistant to the maximal antilipolytic effect of insulin. The insulin concentration needed to elicit the half-maximal inhibitory effect of insulin was within the physiological range of insulin and was not influenced by adipocyte size or adipose depot. We conclude that overconditioned cows have larger adipocytes and are predisposed to excessive mobilization of body fat due to a higher basal and stimulated lipolytic activity of large adipocytes while the antilipolytic effect of insulin is preserved. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Development of Intra-Articular Drug Delivery to Alter Progression of Arthritis Following Joint Injury

DTIC Science & Technology

2012-04-01

2012Revised AnnualApril 2012 DESIGN: A novel injectable and in situ forming drug depot based on thermally-responsive elastin -like polypeptide (ELP) will... Elastin -like polypeptide, Drug Depot – technology allowing sustained release of biologically active agent , Active agents used include IL1Ra...The abstract has been removed and an appendix has been included. In brief this protocol explores the use of elastin like polypeptide (ELP) as a

NASA Shuttle Logistics Depot (NSLD) - The application of ATE

NASA Technical Reports Server (NTRS)

Simpkins, Lorenz G.; Jenkins, Henry C.; Mauceri, A. Jack

1990-01-01

The concept of the NASA Shuttle Logistics Depot (NSLD) developed for the Space Shuttle Orbiter Program is described. The function of the NSLD at Cape Canaveral is to perform the acceptance and diagnostic testing of the Shuttle's space-rated line-replaceable units and shop-replaceable units (SRUs). The NSLD includes a comprehensive electronic automatic test station, program development stations, and assorted manufacturing support equipment (including thermal and vibration test equipment, special test equipment, and a card SRU test system). The depot activities also include the establishment of the functions for manufacturing of mechanical parts, soldering, welding, painting, clean room operation, procurement, and subcontract management.

Umatilla River Subbasin Fish Habitat Improvement Program, 1996-2003 Summary Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

St. Hilaire, Danny R.; Montgomery, Michael; Bailey, Timothy D.

This annual report is in fulfillment of contractual obligations with Bonneville Power Administration (BPA), which is the funding source for the Oregon Department of Fish and Wildlife's (ODFW), Umatilla River Subbasin Fish Habitat Improvement Program (Program). The last Annual Program Report was submitted in 1997, and described projects undertaken in 1995. This report describes Program activities carried out in 2003, along with a summary of projects undertaken during the years 1996 through 2002. The Program works cooperatively with private landowners to develop long-term restoration agreements, under which, passive and active Habitat Improvement Projects are conducted. Historically, projects have included livestockmore » exclusion fencing (passive restoration) to protect riparian habitats, along with the installation of instream structures (active restoration) to address erosion and improve fish habitat. In recent years, the focus of active restoration has shifted to bioengineering treatments and, more recently, to channel re-design and re-construction aimed at improving fish habitat, by restoring stable channel function. This report provides a summary table of past projects (1996-2002), along with a text description of more extensive habitat improvement projects, including: (1) Implementation of a four-phased project on the Lobato property (Birch Creek) beginning in 1996 and involving a demonstration bioengineering site and riparian improvements (fencing, planting), (2) Implementation of stable channel design/instream structure placement on the Houser property, East Birch Creek, beginning in 1998, an (3) Implementation of a joint, US Army Corps of Engineers/ODFW (cost share) project beginning in 2001 on the Brogoitti property, East Birch Creek, which involved implementation of stable channel design/construction and riparian improvement treatments.« less

Multimodal imaging approach to examine biodistribution kinetics of Cabotegravir (GSK1265744) long acting parenteral formulation in rat.

PubMed

Jucker, Beat M; Alsaid, Hasan; Rambo, Mary; Lenhard, Stephen C; Hoang, Bao; Xie, Fang; Groseclose, M Reid; Castellino, Stephen; Damian, Valeriu; Bowers, Gary; Gupta, Manish

2017-12-28

Long-Acting Parenterals (LAPs) have been used in the clinic to provide sustained therapeutic drug levels at a target site, and thereby reducing the frequency of dosing required. In an effort to understand the factors associated with long-acting cabotegravir (GSK1265744 LAP) pharmacokinetic variability, the current study was designed to investigate the temporal relationship between intramuscular (IM) or subcutaneous (SC) drug depot morphology and distribution kinetics with plasma pharmacokinetics. Therefore, a multi-modal molecular imaging (MRI & MALDI IMS) approach was employed to examine the temporal GSK1265744 LAP biodistribution in rat following either IM or SC administration. Serial MRI was performed immediately post drug administration, and then at day 1 (24h post), 2, 3, 4, 7, and 14. In a separate cohort of rats, an MRI contrast agent, Feraheme® (USPIO), was administered 2days post IM drug injection in order to investigate the potential involvement of macrophages trafficking to the GSK1265744 LAP and Vehicle depot sites. The GSK1265744 LAP depot volume increased rapidly by day 2 in the IM injected rats (~3-7 fold) compared with a ~1 fold increase in the SC injected rats. In addition, the USPIO contrast agent labeled macrophages were shown to be present in the depot region of the GSK1265744 LAP injected gastrocnemius while the Vehicle injected gastrocnemius appeared to show reduced uptake. Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) of muscle and abdominal tissue sections identified the drug content primarily within the depot. Co-registration of the GSK1265744 ion images with immunohistochemical images established that the drug was taken up by macrophages associated with the depot. Linear regression analysis demonstrated that the drug depot characteristics including volume, surface area, and perimeter assessed by MRI at day 2 correlated with early time point plasma drug concentrations. In summary, a multimodal molecular imaging approach was used to identify the drug depot location and volumetric/physiologic changes in both IM and SC locations following GSK1265744 LAP administration. The IM depot volume increased rapidly to a maximum volume at 2days post-GSK1265744 LAP administration, while the Vehicle depot did not suggesting that the active drug substance and/or related particle was a key driver for drug depot evolution. The depot expansion was associated with an increase in macrophage infiltration and edema in and around the depot region and was correlated to plasma drug concentration at early time points (0-4days). Consequently, molecular imaging approaches may be used in patients to help understand the biodistribution of GSK1265744 LAP and its associated pharmacokinetics. Copyright © 2017 Elsevier B.V. All rights reserved.

Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat

PubMed Central

Bujalska, Iwona J; Durrani, Omar M; Abbott, Joseph; Onyimba, Claire U; Khosla, Pamela; Moosavi, Areeb H; Reuser, Tristan T Q; Stewart, Paul M; Tomlinson, Jeremy W; Walker, Elizabeth A; Rauz, Saaeha

2007-01-01

Glucocorticoids (GCs) have a profound effect on adipose biology increasing tissue mass causing central obesity. The pre-receptor regulation of GCs by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that activates cortisol from cortisone has been postulated as a fundamental mechanism underlying the metabolic syndrome mediating adipocyte hyperplasia and hypertrophy in the omental (OM) depot. Orbital adipose tissue (OF) is the site of intense inflammation and tissue remodelling in several orbital inflammatory disease states. In this study, we describe features of the GC metabolic pathways in normal human OF depot and compare it with subcutaneous (SC) and OM depots. Using an automated histological characterisation technique, OF adipocytes were found to be significantly smaller (parameters: area, maximum diameter and perimeter) than OM and SC adipocytes (P<0·001). Although immunohistochemical analyses demonstrated resident CD68+ cells in all three whole tissue adipose depots, OF CD68 mRNA and protein expression exceeded that of OM and SC (mRNA, P<0·05; protein, P<0·001). In addition, there was higher expression of glucocorticoid receptor (GR)α mRNA in the OF whole tissue depot (P<0·05). Conversely, 11β-HSD1 mRNA together with the markers of late adipocyte differentiation (FABP4 and G3PDH) were significantly lower in OF. Primary cultures of OF preadipocytes demonstrated predominant 11β-HSD1 oxo-reductase activity with minimal dehydrogenase activity. Orbital adipocytes are smaller, less differentiated, and express low levels of 11β-HSD1 but abundant GRα compared with SC and OM. OF harbours a large CD68+ population. These characteristics define an orbital microenvironment that has the potential to respond to sight-threatening orbital inflammatory disease. PMID:17283228

Use of Nanoscale Emulsified Zero-valent Iron to Treat a Chlorinated Solvent Source Zone at Site 45, Marine Corp Recruit Depot, Parris Island, South Carolina

EPA Science Inventory

This document summarizes the research activities currently underway at the Solid Waste Management Unit 45 (Site 45), Marine Corps Recruit Depot, Parris Island, South Carolina. A pilot field test was initiated in 2005 at this site to evaluate the effectiveness of nanoscale emulsif...

Radiological Scoping Survey of the Scotia Depot Scotia, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

E. N. Bailey

2005-02-05

At the request of the Defense Logistics Agency, the Oak Ridge Institute for Science and Education conducted radiological scoping surveys of the Scotia Depot during the period of September 24 through 27, 2007. The scoping survey included visual inspections and limited radiological surveys performed in accordance with area classification that included surface scans, total and removable activity measurements, and soil sampling.

The Viability of the Air Mobility Command Pure Pallet Program for US Army Reparable Retrograde Shipments

DTIC Science & Technology

2007-03-01

workload falls upon the Army depots in Anniston and Red River in Texarkana , Texas and must rely on the DOD transportation system for air and surface...Dover Air Force Base with final destinations of Red River Army Depot (DOD Activity Address Code: W45G19 and SW3227) in Texarkana , Texas and Anniston

Role of innate immune receptors TLR2 and TLR4 as mediators of the inflammatory reaction in human visceral adipose tissue.

PubMed

Fusaru, Ana Marina; Stănciulescu, Camelia Elena; Surlin, V; Taisescu, C; Bold, Adriana; Pop, O T; Baniţă, Ileana Monica; Crăiţoiu, Stefania; Pisoschi, Cătălina Gabriela

2012-01-01

White adipose tissue from different locations is characterized by significant differences in the structure of adipocyte "secretoma". Fat accumulation in the central-visceral depots is usually associated with a chronic inflammatory state, which is complicated by the metabolic syndrome. Recently, the adipose tissue was emerged to have an essential role in the innate immunity, adipocytes being considered effector cells due to the presence of the Toll-like receptors (TLRs). In this study, we compared the expression of TNF-α, TLR2 and TLR4 in peripheral-subcutaneous and central-peritoneal adipose depots in three different conditions - lean, obese and obese diabetic - using immunohistochemistry. Our results suggest a correlation between the incidence of the stromal vascular cells and adipocytes TNF-α and TLR4 in the visceral depots in strong correlation with adipose tissue expansion. TLR2 positive cells were seen in the peripheral depots from all groups without any association with fat accumulation. These results focus on the existence of a new pathogenic pathway, the activation of TLR4, for the involvement of visceral adipose tissue in the activation and maintenance of the inflammatory cascade in obesity.

Antitumor efficacy and intratumoral distribution of SN-38 from polymeric depots in brain tumor model

PubMed Central

Vejjasilpa, Ketpat; Manaspon, Chawan; Larbcharoensub, Noppadol; Boongird, Atthaporn; Hongeng, Suradej; Israsena, Nipan

2015-01-01

We investigate antitumor efficacy and 2D and 3D intratumoral distribution of 7-ethyl-10-hydroxycamptothecin (SN-38) from polymeric depots inside U-87MG xenograft tumor model in nude mice. Results showed that polymeric depots could be used to administer and controlled release of a large amount of SN-38 directly to the brain tumor model. SN-38 released from depots suppressed tumor growth, where the extent of suppression greatly depended on doses and the number of depot injections. Tumor suppression of SN-38 from depots was three-fold higher in animals which received double injections of depots at high dose (9.7 mg of SN-38) compared to single injection (2.2 mg). H&E staining of tumor sections showed that the area of tumor cell death/survival of the former group was two-fold higher than those of the latter group. Fluorescence imaging based on self-fluorescent property of SN-38 was used to evaluate the intratumoral distribution of this drug compared to histological results. The linear correlation between fluorescence intensity and the amount of SN-38 allowed quantitative determination of SN-38 in tumor tissues. Results clearly showed direct correlation between the amount of SN-38 in tumor sections and cancer cell death. Moreover, 3D reconstruction representing the distribution of SN-38 in tumors was obtained. Results from this study suggest the rationale for intratumoral drug administration and release of drugs inside tumor, which is necessary to design drug delivery systems with efficient antitumor activity. PMID:26080460

In-Space Propellant Production Using Water

NASA Technical Reports Server (NTRS)

Notardonato, William; Johnson, Wesley; Swanger, Adam; McQuade, William

2012-01-01

A new era of space exploration is being planned. Manned exploration architectures under consideration require the long term storage of cryogenic propellants in space, and larger science mission directorate payloads can be delivered using cryogenic propulsion stages. Several architecture studies have shown that in-space cryogenic propulsion depots offer benefits including lower launch costs, smaller launch vehicles, and enhanced mission flexibility. NASA is currently planning a Cryogenic Propellant Storage and Transfer (CPST) technology demonstration mission that will use existing technology to demonstrate long duration storage, acquisition, mass gauging, and transfer of liquid hydrogen in low Earth orbit. This mission will demonstrate key technologies, but the CPST architecture is not designed for optimal mission operations for a true propellant depot. This paper will consider cryogenic propellant depots that are designed for operability. The operability principles considered are reusability, commonality, designing for the unique environment of space, and use of active control systems, both thermal and fluid. After considering these operability principles, a proposed depot architecture will be presented that uses water launch and on orbit electrolysis and liquefaction. This could serve as the first true space factory. Critical technologies needed for this depot architecture, including on orbit electrolysis, zero-g liquefaction and storage, rendezvous and docking, and propellant transfer, will be discussed and a developmental path forward will be presented. Finally, use of the depot to support the NASA Science Mission Directorate exploration goals will be presented.

In-Space Cryogenic Propellant Depot Stepping Stone

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Mankins, John C.; Fikes, John C.

2005-01-01

An In-Space Cryogenic Propellant Depot (ISCPD) is an important stepping stone to provide the capability to preposition, store, manufacture, and later use the propellants for Earth-Neighborhood campaigns and beyond. An in-space propellant depot will provide affordable propellants and other similar consumables to support the development of sustainable and affordable exploration strategies as well as commercial space activities. An in-space propellant depot not only requires technology development in key areas such as zero boil-off storage and fluid transfer, but in other areas such as lightweight structures, highly reliable connectors, and autonomous operations. These technologies can be applicable to a broad range of propellant depot concepts or specific to a certain design. In addition, these technologies are required for spacecraft and orbit transfer vehicle propulsion and power systems, and space life support. Generally, applications of this technology require long-term storage, on-orbit fluid transfer and supply, cryogenic propellant production from water, unique instrumentation and autonomous operations. This paper discusses the reasons why such advances are important to future affordable and sustainable operations in space. This paper also discusses briefly R&D objectives comprising a promising approach to the systems planning and evolution into a meaningful stepping stone design, development, and implementation of an In-Space Cryogenic Propellant Depot. The success of a well-planned and orchestrated approach holds great promise for achieving innovation and revolutionary technology development for supporting future exploration and development of space.

Depot Maintenance: Improved Strategic Planning Needed to Ensure That Army and Marine Corps Depots Can Meet Future Maintenance Requirements

DTIC Science & Technology

2009-09-01

System, and Sidewinder, as well as mobile electric power generation equipment Red River Texarkana , Texas Bradley Fighting Vehicle, tactical wheeled...Depot, Corpus Christi, Texas; Letterkenny Army Depot, Chambersburg, Pennsylvania; Red River Army Depot, Texarkana , Texas; and Tobyhanna Army Depot

The sexual dimorphism of obesity

PubMed Central

Palmer, Biff F.; Clegg, Deborah J.

2015-01-01

The NIH has recently highlighted the importance of sexual dimorphisms and has mandated inclusion of both sexes in clinical trials and basic research. In this review we highlight new and novel ways sex hormones influence body adiposity and the metabolic syndrome. Understanding how and why metabolic processes differ by sex will enable clinicians to target and personalize therapies based on gender. Adipose tissue function and deposition differ by sex. Females differ with respect to distribution of adipose tissues, males tend to accrue more visceral fat, leading to the classic android body shape which has been highly correlated to increased cardiovascular risk; whereas females accrue more fat in the subcutaneous depot prior to menopause, a feature which affords protection from the negative consequences associated with obesity and the metabolic syndrome. After menopause, fat deposition and accrual shift to favor the visceral depot. This shift is accompanied by a parallel increase in metabolic risk reminiscent to that seen in men. A full understanding of the physiology behind why, and by what mechanisms, adipose tissues accumulate in specific depots and how these depots differ metabolically by sex is important in efforts of prevention of obesity and chronic disease. Estrogens, directly or through activation of their receptors on adipocytes and in adipose tissues, facilitate adipose tissue deposition and function. Evidence suggests that estrogens augment the sympathetic tone differentially to the adipose tissue depots favoring lipid accumulation in the subcutaneous depot in women and visceral fat deposition in men. At the level of adipocyte function, estrogens and their receptors influence the expandability of fat cells enhancing the expandability in the subcutaneous depot and inhibiting it in the visceral depot. Sex hormones clearly influence adipose tissue function and deposition, determining how to capture and utilize their function in a time of caloric surfeit, requires more information. The key will be harnessing the beneficial effects of sex hormones in such a way as to provide ‘healthy’ adiposity. PMID:25578600

Depot differences in steroid receptor expression in adipose tissue: possible role of the local steroid milieu.

PubMed

Rodriguez-Cuenca, S; Monjo, M; Proenza, A M; Roca, P

2005-01-01

Sex hormones play an important role in adipose tissue metabolism by activating specific receptors that alter several steps of the lipolytic and lipogenic signal cascade in depot- and sex-dependent manners. However, studies focusing on steroid receptor status in adipose tissue are scarce. In the present study, we analyzed steroid content [testosterone (T), 17beta-estradiol (17beta-E2), and progesterone (P4)] and steroid receptor mRNA levels in different rat adipose tissue depots. As expected, T levels were higher in males than in females (P = 0.031), whereas the reverse trend was observed for P4 (P < 0.001). It is noteworthy that 17beta-E2 adipose tissue levels were higher in inguinal than in the rest of adipose tissues for both sexes, where no sex differences in 17beta-E2 tissue levels were noted (P = 0.010 for retroperitoneal, P = 0.005 for gonadal, P = 0.018 for mesenteric). Regarding steroid receptor levels, androgen (AR) and estrogen receptor (ER)alpha and ERbeta densities were more clearly dependent on adipose depot location than on sex, with visceral depots showing overall higher mRNA densities than their subcutaneous counterparts. Besides, expression of ERalpha predominated over ERbeta expression, and progesterone receptor (PR-B form and PR-A+B form) mRNAs were identically expressed regardless of anatomic depot and sex. In vitro studies in 3T3-L1 cells showed that 17beta-E2 increased ERalpha (P = 0.001) and AR expression (P = 0.001), indicating that estrogen can alter estrogenic and androgenic signaling in adipose tissue. The results highlighted in this study demonstrate important depot-dependent differences in the sensitivity of adipose tissues to sex hormones between visceral and subcutaneous depots that could be related to metabolic situations observed in response to sex hormones.

Enhancement of polycyclic aromatic hydrocarbons in estuarine invertebrates by surface runoff at a decommissioned military fuel depot

USGS Publications Warehouse

Miles, A.K.; Roster, N.

1999-01-01

Accumulation of polycyclic aromatic hydrocarbons (PAHs) was determined in blue mussels (Mytilus spp.) and shore crabs (Hemigrapsus sp.) at a recently closed military fuel depot in central San Francisco Bay, California. In April 1996, during a period of above average precipitation, specimens were collected at the depot, near the depot, and at sites 10 and 20 km south of the depot. Four weeks after the rains ended, blue mussels were again collected at the depot, and at two additional sites in the central Bay region. In April, total PAHs in mussels from the depot were significantly higher only than that in mussels collected 20 km from the depot; however, seven specific, substituted PAHs were higher at the depot than at all other sites. In June, only two of the 38 PAHs common in mussels in April were detected at the depot; these concentrations were comparable to ambient concentrations in mussels at the Bay. It seemed that bioavailability of PAHs at the depot was enhanced by rainfall, probably due to the mobilization of PAHs via groundwater into the Bay. Concentrations in mussels from chronically contaminated sites were about five times higher than mussels collected from the depot. Low PAH concentrations were detected in shore crabs near the depot, and the highest levels were not associated with the depot. Observed PAH concentrations are discussed in relation to upper trophic organisms.

Enhanced Preliminary Assessment Report: Fort Wingate Depot Activity Gallup, New Mexico

DTIC Science & Technology

1990-03-01

Census, 1980 Census of Population. U 20 uranium exploration, mining, and milling, while the trade sector is influenced by the Zuni and Navajo ...Five Indian reservations, eight national park areas ( Navajo , Chaco Canyon, Aztec Ruins, El Moro National Monuments, Mesa Verde, and Petrified Forest...Argonne National Laboratory Argonne, Illinois 60439 IAppmvd bo o. 90 0611 090 CETHA-BC-CR-90051 Enhanced Preliminary Assessment Report: Fort Wingate Depot

KC-46 Workforce Requirements for Depot Maintenance Activation

DTIC Science & Technology

2014-03-27

commercial derivative aircraft . These are aircraft originally designed for commercial aviation but with modifications that change the aircraft to fit the... designing the process to capture the data needed to infer answers to the research questions. More needs to be understood about how aircraft maintenance...Air Force projects receiving new KC-46 aircraft in 2016 and headquarters is directing organic maintenance. Oklahoma City ALC is the depot projected

Development of self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy.

PubMed

Nittayacharn, Pinunta; Nasongkla, Norased

2017-07-01

The objective of this work was to develop self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy and studied the release profiles of doxorubicin (Dox) from different depot formulations. Tri-block copolymers of poly(ε-caprolactone), poly(D,L-lactide) and poly(ethylene glycol) named PLECs were successfully used as a biodegradable material to encapsulate Dox as the injectable local drug delivery system. Depot formation and encapsulation efficiency of these depots were evaluated. Results show that depots could be formed and encapsulate Dox with high drug loading content. For the release study, drug loading content (10, 15 and 20% w/w) and polymer concentration (25, 30, and 35% w/v) were varied. It could be observed that the burst release occurred within 1-2 days and this burst release could be reduced by physical mixing of hydroxypropyl-beta-cyclodextrin (HP-β-CD) into the depot system. The degradation at the surface and cross-section of the depots were examined by Scanning Electron Microscope (SEM). In addition, cytotoxicity of Dox-loaded depots and blank depots were tested against human liver cancer cell lines (HepG2). Dox released from depots significantly exhibited potent cytotoxic effect against HepG2 cell line compared to that of blank depots. Results from this study reveals an important insight in the development of injectable drug delivery system for liver cancer chemotherapy. Schematic diagram of self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system and in vitro characterizations. (a) Dox-loaded PLEC depots could be formed with more than 90% of sustained-release Dox at 25% polymer concentration and 20% Dox-loading content. The burst release occurred within 1-2 days and could be reduced by physical mixing of hydroxypropyl-beta-cyclodextrin (HP-β-CD) into the depot system. (b) Dox released from depots significantly exhibited potent cytotoxic effect against human liver cancer cell lines (HepG2 cell line) compared to that of blank depots. (c) Dox-loaded depots showed bulk erosion with hollow core at day 60.

The evolution of Orbiter depot support, with applications to future space vehicles

NASA Technical Reports Server (NTRS)

Mcclain, Michael L.

1990-01-01

The reasons for depot consolidation and the processes established to implement the Orbiter depot are presented. The Space Shuttle Orbiter depot support is presently being consolidated due to equipment suppliers leaving the program, escalating depot support costs, and increasing repair turnaround times. Details of the depot support program for orbiter hardware and selected pieces of support equipment are discussed. The benefits gained from this consolidation and the lessons learned are then applied to future reuseable space vehicles to provide program managers a forward look at the need for efficient depot support.

Walla Walla River Fish Passage Operations Project : Annual Progress Report October 2007 - September 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bronson, James P.; Duke, Bill; Loffink, Ken

2008-12-30

In the late 1990s, the Confederated Tribes of the Umatilla Indian Reservation, Oregon Department of Fish and Wildlife, and Washington Department of Fish and Wildlife, along with many other agencies, began implementing fisheries restoration activities in the Walla Walla Basin. An integral part of these efforts is to alleviate the inadequate fish migration conditions in the basin. Migration concerns are being addressed by removing diversion structures, constructing fish passage facilities, implementing minimum instream flow requirements, and providing trap and haul efforts when needed. The objective of the Walla Walla River Fish Passage Operations Project is to increase the survival ofmore » migrating adult and juvenile salmonids in the Walla Walla River basin. The project is responsible for coordinating operation and maintenance of ladders, screen sites, bypasses, trap facilities, and transportation equipment. In addition, the project provides technical input on passage and trapping facility design, operation, and criteria. Operation of the various passage facilities and passage criteria guidelines are outlined in an annual operations plan that the project develops. Beginning in March of 2007, two work elements from the Walla Walla Fish Passage Operations Project were transferred to other projects. The work element Enumeration of Adult Migration at Nursery Bridge Dam is now conducted under the Walla Walla Basin Natural Production Monitoring and Evaluation Project and the work element Provide Transportation Assistance is conducted under the Umatilla Satellite Facilities Operation and Maintenance Project. Details of these activities can be found in those project's respective annual reports.« less

7 CFR 924.10 - Size.

Code of Federal Regulations, 2010 CFR

2010-01-01

... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.10 Size. Size means the... stem to the blossom end, or such other specifications as may be established by the committee with the...

7 CFR 924.10 - Size.

Code of Federal Regulations, 2011 CFR

2011-01-01

... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.10 Size. Size means the... stem to the blossom end, or such other specifications as may be established by the committee with the...

Application Forms for Forestry and Silvicultural Burning Tribal Permits Under the FARR

EPA Pesticide Factsheets

Application form for forestry and silvicultural burning on the Nez Perce Indian Reservation and the Confederated Tribes of the Umatilla Indian Reservation under EPA's Federal Air Rules for Reservations.

Evaluation of Sources of Nitrate Beneath Food Processing Wastewater-Application Sites near Umatilla, Oregon

USGS Publications Warehouse

Frans, Lonna; Paulson, Anthony; Richerson, Phil; Striz, Elise; Black, Curt

2009-01-01

Water samples from wells were collected beneath and downgradient of two food-processing wastewater-application sites near Umatilla, Oregon. These samples were analyzed for nitrate stable isotopes, nutrients, major ions, and age-dating constituents to determine if nitrate-stable isotopes can be used to differentiate food-processing waste from other potential sources of nitrate. Major-ion data from each site were used to determine which samples were associated with the recharge of the food-processing wastewater. End-member mixing analysis was used to determine the relative amounts of each identified end member within the samples collected from the Terrace Farm site. The delta nitrogen-15 (delta 15N) of nitrate generally ranged between +2 and +9 parts per thousand and the delta oxygen-18 (delta 18O) of nitrate generally ranged between -2 and -7 parts per thousand. None of the samples that were determined to be associated with the wastewater were different from the samples that were not affected by the wastewater. The nitrate isotope values measured in this study are also characteristic of ammonium fertilizer, animal and human waste, and soil nitrate; therefore, it was not possible to differentiate between food-processing wastewater and the other nitrate sources. Values of delta 15N and delta 18O of nitrate provided no more information about the sources of nitrate in the Umatilla River basin than did a hydrologic and geochemical understanding of the ground-water system derived from interpreting water-level and major-ion chemistry data.

An Archeological Overview and Management Plan for the Tobyhanna Army Depot.

DTIC Science & Technology

1984-09-01

important activity in the region between 1755 and 1781. The French and Indian War (1755-1763), the first Pennimite War (1769-1776), and the American ...ARCHEOLOGICAL RESOURCES ON THE TOBYHANNA ARMY DEPOT Native Americans who may have utilized the Pocono region during the seventeenth and eighteenth centuries...mountain laurel. Native American inhabitants of the region would most likely have found this location marginal for gathered plant foods. In particular, nut

Risperidone (depot) for schizophrenia.

PubMed

Sampson, Stephanie; Hosalli, Prakash; Furtado, Vivek A; Davis, John M

2016-04-14

Risperidone is the first new generation antipsychotic drug made available in a long-acting injection formulation. To examine the effects of depot risperidone for treatment of schizophrenia or related psychoses in comparison with placebo, no treatment or other antipsychotic medication.To critically appraise and summarise current evidence on the resource use, cost and cost-effectiveness of risperidone (depot) for schizophrenia. We searched the Cochrane Schizophrenia Group's Register (December 2002, 2012, and October 28, 2015). We also checked the references of all included studies, and contacted industry and authors of included studies. Randomised clinical trials comparing depot risperidone with other treatments for people with schizophrenia and/or schizophrenia-like psychoses. Two review authors independently selected trials, assessed trial quality and extracted data. For dichotomous data, we calculated the risk ratio (RR), with 95% confidence interval (CI). For continuous data, we calculated mean differences (MD). We assessed risk of bias for included studies and created 'Summary of findings' tables using GRADE. Twelve studies, with a total of 5723 participants were randomised to the following comparison treatments: Risperidone depot versus placebo Outcomes of relapse and improvement in mental state were neither measured or reported. In terms of other primary outcomes, more people receiving placebo left the study early by 12 weeks (1 RCT, n=400, RR 0.74 95% CI 0.63 to 0.88, very low quality evidence), experienced severe adverse events in short term (1 RCT, n=400, RR 0.59 95% CI 0.38 to 0.93, very low quality evidence). There was however, no difference in levels of weight gain between groups (1 RCT, n=400, RR 2.11 95% CI 0.48 to 9.18, very low quality evidence). Risperidone depot versus general oral antipsychotics The outcome of improvement in mental state was not presented due to high levels of attrition, nor were levels of severe adverse events explicitly reported. Most primary outcomes of interest showed no difference between treatment groups. However, more people receiving depot risperidone experienced nervous system disorders (long-term:1 RCT, n=369, RR 1.34 95% CI 1.13 to 1.58, very-low quality evidence). Risperidone depot versus oral risperidoneData for relapse and severe adverse events were not reported. All outcomes of interest were rated as moderate quality evidence. Main results showed no differences between treatment groups with equivocal data for change in mental state, numbers leaving the study early, any extrapyramidal symptoms, weight increase and prolactin-related adverse events. Risperidone depot versus oral quetiapine Relapse rates and improvement in mental state were not reported. Fewer people receiving risperidone depot left the study early (long-term: 1 RCT, n=666, RR 0.84 95% CI 0.74 to 0.95, moderate quality evidence). Experience of serious adverse events was similar between groups (low quality evidence), but more people receiving depot risperidone experienced EPS (1 RCT, n=666, RR 1.83 95% CI 1.07 to 3.15, low quality evidence), had greater weight gain (1 RCT, n=666, RR 1.25 95% CI 0.25 to 2.25, low quality evidence) and more prolactin-related adverse events (1 RCT, n=666, RR 3.07 95% CI 1.13 to 8.36, very low quality evidence). Risperidone depot versus oral aripiprazoleRelapse rates, mental state using PANSS, leaving the study early, serious adverse events and weight increase were similar between groups. However more people receiving depot risperidone experienced prolactin-related adverse events compared to those receiving oral aripiprazole (2 RCTs, n=729, RR 9.91 95% CI 2.78 to 35.29, very low quality of evidence). Risperidone depot versus oral olanzapineRelapse rates were not reported in any of the included studies for this comparison. Improvement in mental state using PANSS and instances of severe adverse events were similar between groups. More people receiving depot risperidone left the study early than those receiving oral olanzapine (1 RCT, n=618, RR 1.32 95% CI 1.10 to 1.58, low quality evidence) with those receiving risperidone depot also experiencing more extrapyramidal symptoms (1 RCT, n=547, RR 1.67 95% CI 1.19 to 2.36, low quality evidence). However, more people receiving oral olanzapine experienced weight increase (1 RCT, n=547, RR 0.56 95% CI 0.42 to 0.75, low quality evidence). Risperidone depot versus atypical depot antipsychotics (specifically paliperidone palmitate)Relapse rates were not reported and rates of response using PANSS, weight increase, prolactin-related adverse events and glucose-related adverse events were similar between groups. Fewer people left the study early due to lack of efficacy from the risperidone depot group (long term: 1 RCT, n=749, RR 0.60 95% CI 0.45 to 0.81, low quality evidence), but more people receiving depot risperidone required use of EPS-medication (2 RCTs, n=1666, RR 1.46 95% CI 1.18 to 1.8, moderate quality evidence). Risperidone depot versus typical depot antipsychoticsOutcomes of relapse, severe adverse events or movement disorders were not reported. Outcomes relating to improvement in mental state demonstrated no difference between groups (low quality evidence). However, more people receiving depot risperidone compared to other typical depots left the study early (long-term:1 RCT, n=62, RR 3.05 95% CI 1.12 to 8.31, low quality evidence). Depot risperidone may be more acceptable than placebo injection but it is hard to know if it is any more effective in controlling the symptoms of schizophrenia. The active drug, especially higher doses, may be associated with more movement disorders than placebo. People already stabilised on oral risperidone may continue to maintain benefit if treated with depot risperidone and avoid the need to take tablets, at least in the short term. In people who are happy to take oral medication the depot risperidone is approximately equal to oral risperidone. It is possible that the depot formulation, however, can bring a second-generation antipsychotic to people who do not reliably adhere to treatment. People with schizophrenia who have difficulty adhering to treatment, however, are unlikely to volunteer for a clinical trial. Such people may gain benefit from the depot risperidone with no increased risk of extrapyramidal side effects.

Sympathetic denervation of one white fat depot changes norepinephrine content and turnover in intact white and brown fat depots

PubMed Central

Harris, Ruth B.S.

2013-01-01

It is well established that the sympathetic nervous system regulates adipocyte metabolism and recently it has been reported that sensory afferents from white fat overlap anatomically with sympathetic efferents to white fat. The studies described here characterize the response of intact fat pads to selective sympathectomy (local 6-hydroxydopamine injections) of inguinal (ING) or epididymal (EPI) fat in male NIH Swiss mice and provide in vivo evidence for communication between individual white and brown fat depots. The contralateral ING pad, both EPI pads, perirenal and mesenteric pads were significantly enlarged four weeks after denervating one ING pad, but only intrascapular brown fat (IBAT) increased when both ING pads were denervated. Denervation of one or both EPI pad had no effect on fat depot weights. In an additional experiment, NE turnover was inhibited in ING, retroperitoneal, mesenteric and IBAT two days after denervation of both EPI or of both ING pads. NE content was reduced to 10-30% of control values in all fat depots. There was no relation between early changes in NE turnover and fat pad weight 4 weeks after denervation, even though the reduction in NE content of intact fat pads was maintained. These data demonstrate that there is communication among individual fat pads, presumably through central integration of activity of sensory afferent and sympathetic efferent fibers,that changes sympathetic drive to white adipose tissue in a unified manner. In specific situations, removal of sympathetic efferents to one pad induces a compensatory enlargement of other intact depots. PMID:22513494

Preferential Expression of PAPP-A in Human Preadipocytes from Omental Fat

PubMed Central

Davidge-Pitts, Caroline; Escande, Carlos J.; Conover, Cheryl A.

2014-01-01

Fat distribution differs between individuals, and those with visceral fat predominance develop metabolic profiles that increase risk of adverse cardiovascular events. This is due, in part, to the proinflammatory state associated with visceral obesity as well as depot-specific adipogenesis. The insulin-like growth factor (IGF) system is important in adipose tissue development and metabolic function. Pregnancy associated plasma protein-A (PAPP-A) is a novel zinc metalloproteinase that regulates local IGF availability. The first aim of this study was to characterize PAPP-A mRNA and protein expression in primary cultures of human preadipocytes isolated from omental, mesenteric and subcutaneous depots. PAPP-A expression was significantly increased in omental preadipocytes compared to mesenteric and subcutaneous preadipocytes. The second aim was to investigate factors regulating PAPP-A expression, focusing on proinflammatory cytokines and resveratrol that have been shown to have negative and positive effects, respectively, on metabolism and diet-induced obesity. Treatment of cultured primary human preadipocytes with tumor necrosis factor (TNF)-α and interleukin (IL) 1-β led to significant increases in PAPP-A expression. Activated pathways mediating cytokine-induced PAPP-A expression include the nuclear factor (NF) κB pathway and the mitogen activated protein kinase (MAPK) family, particularly c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated kinase. Resveratrol, a polyphenol with beneficial cardiometabolic effects, significantly down-regulated PAPP-A expression under basal and stimulated conditions. Resveratrol appeared to mediate its effects on PAPP-A through pathways independent of silent mating type information regulation 2 homolog 1 (SIRT1) and AMP kinase (AMPK) activation. Depot-specific PAPP-A expression in human preadipocytes may contribute to depot-specific function. PMID:24781252

In situ geophysical investigation at Proposed Chemical Demilitarization Facility, Lexington Bluegrass Army Depot, Lexington, Kentucky. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Llopis, J.L.; Lee, L.T.

1996-02-01

Current computerized seismic wave propagation analysis procedures for building foundations require that values of shear-wave (S-wave) propagation velocities as a function of depth be determined. The S-wave velocities are used in conjunction with conventional field sampling and laboratory testing to provide soil property information for a dynamic analysis of buildings and their foundations. The Lexington Bluegrass Army Depot, Bluegrass Activity, is located approximately 20 miles south of Lexington, KY in the city of Richmond, in east central Kentucky as shown in Figure 1. A chemical demilitarization (Chem- Demil) facility is planned to be built at the depot. The Chem-Demil facilitymore » will be used to incinerate nerve gas presently stockpiled at the site.« less

Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots.

PubMed

Mardian, Emily B; Bradley, Ryan M; Aristizabal Henao, Juan J; Marvyn, Phillip M; Moes, Katherine A; Bombardier, Eric; Tupling, A Russell; Stark, Ken D; Duncan, Robin E

2017-10-01

Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of triacyl-glycerol (TAG). We investigated the effect of Agpat4 gene ablation on white adipose tissue (WAT) after finding consistent expression across depots. Epididymal WAT mass was 40% larger in male Agpat4 -/- mice than wild-type littermates, but unchanged in perirenal, retroperitoneal, and inguinal WAT and subscapular brown adipose tissue. Metabolic changes were identified in epididymal WAT that were not evident in perirenal WAT, which was analyzed for comparison. The total epididymal TAG content doubled, increasing adipocyte cell size without changing markers of differentiation. Enzymes involved in de novo lipogenesis and complex lipid synthesis downstream of phosphatidic acid production were also unchanged. However, total epididymal TAG hydrolase activity was reduced, and there were significant decreases in total ATGL and reduced phosphorylation of hormone-sensitive lipase at the S563 and S660 PKA-activation sites. Analysis of Agpats 1, 2, 3 , and 5 , as well as Gpats 1, 2, 3, and 4, demonstrated compensatory upregulation in perirenal WAT that did not occur in epididymal WAT. Our findings therefore indicate depot-specific differences in the redundancy of Agpat4 and highlight the molecular and metabolic heterogeneity of individual visceral depots. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

Techno-economic analysis of decentralized biomass processing depots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamers, Patrick; Roni, Mohammad S.; Tumuluru, Jaya S.

Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from ~US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipmentmore » such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued.« less

Techno-economic analysis of decentralized biomass processing depots

DOE PAGES

Lamers, Patrick; Roni, Mohammad S.; Tumuluru, Jaya S.; ...

2015-07-08

Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from ~US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipmentmore » such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued.« less

Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty.

PubMed

Freire, Analía Verónica; Gryngarten, Mirta Graciela; Ballerini, María Gabriela; Arcari, Andrea Josefina; Escobar, María Eugenia; Bergadá, Ignacio; Ropelato, María Gabriela

2016-01-01

Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment. E2-24h after depot triptorelin was >100 pg/ml after the first dose. Estradiol response (E2-24h) fell to levels <14 pg/ml in 78 out of 82 follow-up visits along 2 years of therapy. Concomitantly, LH-3h and FSH-3h were <4.0 and <6.3 IU/l, respectively. In 4 patients with inadequate treatment, E2-24h, LH-3h and FSH-3h rose to pubertal values similar to those observed at first dose. Estradiol (<14 pg/ml) assessment 24 h after depot triptorelin administration is a reliable and simple manner to confirm ovarian suppression in CPP girls during treatment. © 2015 S. Karger AG, Basel.

Computer-aided acquisition and logistics support (CALS): Concept of Operations for Depot Maintenance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bourgeois, N.C.; Greer, D.K.

1993-04-01

This CALS Concept of Operations for Depot Maintenance provides the foundation strategy and the near term tactical plan for CALS implementation in the depot maintenance environment. The user requirements enumerated and the overarching architecture outlined serve as the primary framework for implementation planning. The seamless integration of depot maintenance business processes and supporting information systems with the emerging global CALS environment will be critical to the efficient realization of depot user's information requirements, and as, such will be a fundamental theme in depot implementations.

78 FR 52425 - Establishment of Class E Airspace; Umatilla, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

..., Georgia 30320; telephone (404) 305-6364. SUPPLEMENTARY INFORMATION: History On June 4, 2013, the FAA...: Paragraph 6005 Class E Airspace Areas Extending Upward from 700 feet or More Above the Surface of the Earth...

Techno-economic analysis of decentralized biomass processing depots.

PubMed

Lamers, Patrick; Roni, Mohammad S; Tumuluru, Jaya S; Jacobson, Jacob J; Cafferty, Kara G; Hansen, Jason K; Kenney, Kevin; Teymouri, Farzaneh; Bals, Bryan

2015-10-01

Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from ∼US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipment such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued. Copyright © 2015. Published by Elsevier Ltd.

Sex and depot differences in ex vivo adipose tissue fatty acid storage and glycerol-3-phosphate acyltransferase activity

PubMed Central

Morgan-Bathke, Maria; Chen, Liang; Oberschneider, Elisabeth; Harteneck, Debra

2015-01-01

Adipose tissue fatty acid storage varies according to sex, adipose tissue depot, and degree of fat gain. However, the mechanism(s) for these variations is not completely understood. We examined whether differences in adipose tissue glycerol-3-phosphate acyltransferase (GPAT) might play a role in these variations. We optimized an enzyme activity assay for total GPAT and GPAT1 activity in human adipose tissue and measured GPAT activity. Omental and subcutaneous adipose tissue was collected from obese and nonobese adults for measures of GPAT and GPAT1 activities, ex vivo palmitate storage, acyl-CoA synthetase (ACS) and diacylglycerol-acyltransferase (DGAT) activities, and CD36 protein. Total GPAT and GPAT1 activities decreased as a function of adipocyte size in both omental (r = −0.71, P = 0.003) and subcutaneous (r = −0.58, P = 0.04) fat. The relative contribution of GPAT1 to total GPAT activity increased as a function of adipocyte size, accounting for up to 60% of GPAT activity in those with the largest adipocytes. We found strong, positive correlations between ACS, GPAT, and DGAT activities for both sexes and depots (r values 0.58–0.91) and between these storage factors and palmitate storage rates into TAG (r values 0.55–0.90). We conclude that: 1) total GPAT activity decreases as a function of adipocyte size; 2) GPAT1 can account for over half of adipose GPAT activity in hypertrophic obesity; and 3) ACS, GPAT, and DGAT are coordinately regulated. PMID:25738782

Space Transportation Infrastructure Supported By Propellant Depots

NASA Technical Reports Server (NTRS)

Smitherman, David; Woodcock, Gordon

2011-01-01

A space transportation infrastructure is described that utilizes propellant depots to support all foreseeable missions in the Earth-Moon vicinity and deep space out to Mars. The infrastructure utilizes current expendable launch vehicles such as the Delta IV Heavy, Atlas V, and Falcon 9, for all crew, cargo, and propellant launches to orbit. Propellant launches are made to a Low-Earth-Orbit (LEO) Depot and an Earth-Moon Lagrange Point 1 (L1) Depot to support new reusable in-space transportation vehicles. The LEO Depot supports missions to Geosynchronous Earth Orbit (GEO) for satellite servicing, and to L1 for L1 Depot missions. The L1 Depot supports Lunar, Earth-Sun L2 (ESL2), Asteroid, and Mars missions. A Mars Orbital Depot is also described to support ongoing Mars missions. New concepts for vehicle designs are presented that can be launched on current 5-meter diameter expendable launch vehicles. These new reusable vehicle concepts include a LEO Depot, L1 Depot, and Mars Orbital Depot based on International Space Station (ISS) heritage hardware. The high-energy depots at L1 and Mars orbit are compatible with, but do not require, electric propulsion tug use for propellant and/or cargo delivery. New reusable in-space crew transportation vehicles include a Crew Transfer Vehicle (CTV) for crew transportation between the LEO Depot and the L1 Depot, a new reusable Lunar Lander for crew transportation between the L1 Depot and the lunar surface, and a Deep Space Habitat (DSH) to support crew missions from the L1 Depot to ESL2, Asteroid, and Mars destinations. A 6 meter diameter Mars lander concept is presented that can be launched without a fairing based on the Delta IV heavy Payload Planners Guide, which indicates feasibility of a 6.5 meter fairing. This lander would evolve to re-usable operations when propellant production is established on Mars. Figure 1 provides a summary of the possible missions this infrastructure can support. Summary mission profiles are presented for each primary mission capability. These profiles are the basis for propellant loads, numbers of vehicles/stages and launches for each mission capability. Data includes the number of launches required for each mission utilizing current expendable launch vehicle systems, and concluding remarks include ideas for reducing the number of launches through incorporation of heavy-lift launch vehicles, solar electric propulsion, and other transportation support concepts.

Architecture Study for a Fuel Depot Supplied from Lunar Resources

NASA Technical Reports Server (NTRS)

Perrin, Thomas M.

2016-01-01

Heretofore, discussions of space fuel depots assumed the depots would be supplied from Earth. However, the confirmation of deposits of water ice at the lunar poles in 2009 suggests the possibility of supplying a space depot with liquid hydrogen/liquid oxygen produced from lunar ice. This architecture study sought to determine the optimum architecture for a fuel depot supplied from lunar resources. Four factors - the location of propellant processing (on the Moon or on the depot), the location of the depot (on the Moon or in cislunar space), and if in cislunar space, where (LEO, GEO, or Earth-Moon L1), and the method of propellant transfer (bulk fuel or canister exchange) were combined to identify 18 potential architectures. Two design reference missions (DRMs) - a satellite servicing mission and a cargo mission to Mars - were used to create demand for propellants, while a third DRM - a propellant delivery mission - was used to examine supply issues. The architectures were depicted graphically in a network diagram with individual segments representing the movement of propellant from the Moon to the depot, and from the depot to the customer

Architecture Study for a Fuel Depot Supplied from Lunar Resources

NASA Technical Reports Server (NTRS)

Perrin, Thomas M.

2016-01-01

Heretofore, discussions of space fuel depots assumed the depots would be supplied from Earth. However, the confirmation of deposits of water ice at the lunar poles in 2009 suggests the possibility of supplying a space depot with liquid hydrogen/liquid oxygen produced from lunar ice. This architecture study sought to determine the optimum architecture for a fuel depot supplied from lunar resources. Four factors - the location of propellant processing (on the Moon or on the depot), the location of the depot (on the Moon, or at L1, GEO, or LEO), the location of propellant transfer (L1, GEO, or LEO), and the method of propellant transfer (bulk fuel or canister exchange) were combined to identify 18 potential architectures. Two design reference missions (DRMs) - a satellite servicing mission and a cargo mission to Mars - were used to create demand for propellants, while a third DRM - a propellant delivery mission - was used to examine supply issues. The architectures were depicted graphically in a network diagram with individual segments representing the movement of propellant from the Moon to the depot, and from the depot to the customer.

* Central Growth Factor Loaded Depots in Bone Tissue Engineering Scaffolds for Enhanced Cell Attraction.

PubMed

Quade, Mandy; Knaack, Sven; Akkineni, Ashwini Rahul; Gabrielyan, Anastasia; Lode, Anja; Rösen-Wolff, Angela; Gelinsky, Michael

2017-08-01

Tissue engineering, the application of stem and progenitor cells in combination with an engineered extracellular matrix, is a promising strategy for bone regeneration. However, its success is limited by the lack of vascularization after implantation. The concept of in situ tissue engineering envisages the recruitment of cells necessary for tissue regeneration from the host environment foregoing ex vivo cell seeding of the scaffold. In this study, we developed a novel scaffold system for enhanced cell attraction, which is based on biomimetic mineralized collagen scaffolds equipped with a central biopolymer depot loaded with chemotactic agents. In humid milieu, as after implantation, the signaling factors are expected to slowly diffuse out of the central depot forming a gradient that stimulates directed cell migration toward the scaffold center. Heparin, hyaluronic acid, and alginate have been shown to be capable of depot formation. By using vascular endothelial growth factor (VEGF) as model factor, it was demonstrated that the release kinetics can be adjusted by varying the depot composition. While alginate and hyaluronic acid are able to reduce the initial burst and prolong the release of VEGF, the addition of heparin led to a much stronger retention that resulted in an almost linear release over 28 days. The biological activity of released VEGF was proven for all variants using an endothelial cell proliferation assay. Furthermore, migration experiments with endothelial cells revealed a relationship between the degree of VEGF retention and migration distance: cells invaded deepest in scaffolds containing a heparin-based depot indicating that the formation of a steep gradient is crucial for cell attraction. In conclusion, this novel in situ tissue engineering approach, specifically designed to recruit and accommodate endogenous cells upon implantation, appeared highly promising to stimulate cell invasion, which in turn would promote vascularization and finally new bone formation.

Depot Maintenance: Executed Workload and Maintenance Operations at DOD Depots

DTIC Science & Technology

2017-02-03

Page 1 GAO-17-82R Depot Maintenance 441 G St. N.W. Washington, DC 20548 February 3, 2017 The Honorable John McCain Chairman The...Smith Ranking Member Committee on Armed Services House of Representatives Depot Maintenance : Executed Workload and Maintenance Operations at DOD...Depots The Department of Defense (DOD) uses its maintenance capabilities to maintain, overhaul, and repair its military weapon systems (such as

A Critique of the DoD Materiel Distribution Study,

DTIC Science & Technology

1979-03-01

are generated on order cycle times by their components: communication times, depot order processing times, depot capacity delay times, and transit...exceeded, the order was placed in one of three priority queues. The order processing time was determined by priority group by depot. A 20-point probability...time was defined to be the sum of communication, depot order processing , depot capacity delay, and transit times. As has been argued, the first three of

Army Industrial Operations: Budgeting and Management of Carryover Could Be Improved

DTIC Science & Technology

2013-06-01

Pine Bluff Arsenal, Pine Bluff, Arkansas; the Red River Army Depot, Texarkana , Texas; the Rock Island Arsenal-Joint Manufacturing and Technology Center...the Corpus Christi Army Depot, Corpus Christi, Texas; the Letterkenny Army Depot, Chambersburg, Pennsylvania; the Red River Army Depot, Texarkana

Technology requirements for an orbiting fuel depot - A necessary element of a space infrastructure

NASA Technical Reports Server (NTRS)

Stubbs, R. M.; Corban, R. R.; Willoughby, A. J.

1988-01-01

Advanced planning within NASA has identified several bold space exploration initiatives. The successful implementation of these missions will require a supporting space infrastructure which would include a fuel depot, an orbiting facility to store, transfer and process large quantities of cryogenic fluids. In order to adequately plan the technology development programs required to enable the construction and operation of a fuel depot, a multidisciplinary workshop was convened to assess critical technologies and their state of maturity. Since technology requirements depend strongly on the depot design assumptions, several depot concepts are presented with their effect of criticality ratings. Over 70 depot-related technology areas are addressed.

Technology requirements for an orbiting fuel depot: A necessary element of a space infrastructure

NASA Technical Reports Server (NTRS)

Stubbs, R. M.; Corban, R. R.; Willoughby, A. J.

1988-01-01

Advanced planning within NASA has identified several bold space exploration initiatives. The successful implementation of these missions will require a supporting space infrastructure which would include a fuel depot, an orbiting facility to store, transfer and process large quantities of cryogenic fluids. In order to adequately plan the technology development programs required to enable the construction and operation of a fuel depot, a multidisciplinary workshop was convened to assess critical technologies and their state of maturity. Since technology requirements depend strongly on the depot design assumptions, several depot concepts are presented with their effect on criticality ratings. Over 70 depot-related technology areas are addressed.

Fatty acid composition of fat depots in wintering Canada geese

USGS Publications Warehouse

Austin, J.E.

1993-01-01

I determined the fatty acid composition of subcutaneous, abdominal, visceral, and leg saddle depots in adult female Canada Geese (Branta canadensis) wintering in north-central Missouri during October 1984-March 1985. Mean levels of C14:0, C16:0, C16:1, C18:0, C18:1, C18:2, and C18:3 generally were highest in the subcutaneous and abdominal depots. The ratio of saturated to unsaturated fats was highest in the leg saddle depot and lowest in the abdominal depot. I also assessed the differences among sexes, seasons, and years in fatty acid composition of abdominal fat depots in adult geese collected during October-March, 1985-1987. Adult females had consistently higher levels of C14:0 in abdominal depots than males. Fatty acid composition of the abdominal depot differed among years but not by season. In the abdominal depot, C14:0, C16:0, C16:1, and C18:1 were higher in 1986-1987 compared with the previous two years, whereas C18:3 was highest in 1984-1985. Differences among years reflected changes in winter diet. Fatty acids of wintering geese were similar to those previously found in breeding Canada Geese.

Depot Maintenance: Improvements to DODs Biennial Core Report Could Better Inform Oversight and Funding Decisions

DTIC Science & Technology

2016-11-01

information, contact Zina Merritt at (202) 512-5257 or merrittz@gao.gov Why GAO Did This Study DOD uses both military depots and contractors to maintain...many complex weapon systems and equipment. Recognizing the key role of the depots and the risk of overreliance on contractors , Section 2464 of...military depots2—public-sector facilities that are government-owned and government-operated—and private-sector contractors . Depots have a key role

7 CFR 1412.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... grain rice, medium grain rice, soybeans, sunflower seed, rapeseed, canola, safflower, flaxseed, mustard seed, crambe, sesame seed, pulse crops, and other oilseeds as determined by the Secretary. Crop year... Austrian, wrinkled seed, yellow, Umatilla, and green, excluding peas grown for the fresh, canning, or...

General perspective view of the North Fork Butter Creek Bridge, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General perspective view of the North Fork Butter Creek Bridge, view looking southwest - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Approach view of the North Fork Butter Creek Bridge, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Approach view of the North Fork Butter Creek Bridge, view looking south - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

General perspective view of the North Fork Butter Creek Bridge, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General perspective view of the North Fork Butter Creek Bridge, view looking north - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Detail view of the concrete arched balustrade railing and bushhammered ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of the concrete arched balustrade railing and bush-hammered inset posts - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Elevation view of the North Fork Butter Creek Bridge, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Elevation view of the North Fork Butter Creek Bridge, view looking west - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Approach view of the North Fork Butter Creek Bridge, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Approach view of the North Fork Butter Creek Bridge, view looking north - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Detail perspective view of the North Fork Butter Creek Bridge, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail perspective view of the North Fork Butter Creek Bridge, view looking southwest - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

General perspective view of the North Fork Butter Creek Bridge, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

General perspective view of the North Fork Butter Creek Bridge, view looking south - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Developing a safe on-orbit cryogenic depot

NASA Technical Reports Server (NTRS)

Bahr, Nicholas J.

1992-01-01

New U.S. space initiatives will require technology to realize planned programs such as piloted lunar and Mars missions. Key to the optimal execution of such missions are high performance orbit transfer vehicles and propellant storage facilities. Large amounts of liquid hydrogen and oxygen demand a uniquely designed on-orbit cryogenic propellant depot. Because of the inherent dangers in propellant storage and handling, a comprehensive system safety program must be established. This paper shows how the myriad and complex hazards demonstrate the need for an integrated safety effort to be applied from program conception through operational use. Even though the cryogenic depot is still in the conceptual stage, many of the hazards have been identified, including fatigue due to heavy thermal loading from environmental and operating temperature extremes, micrometeoroid and/or depot ancillary equipment impact (this is an important problem due to the large surface area needed to house the large quantities of propellant), docking and maintenance hazards, and hazards associated with extended extravehicular activity. Various safety analysis techniques were presented for each program phase. Specific system safety implementation steps were also listed. Enhanced risk assessment was demonstrated through the incorporation of these methods.

Optimizing the Shunting Schedule of Electric Multiple Units Depot Using an Enhanced Particle Swarm Optimization Algorithm

PubMed Central

Jin, Junchen

2016-01-01

The shunting schedule of electric multiple units depot (SSED) is one of the essential plans for high-speed train maintenance activities. This paper presents a 0-1 programming model to address the problem of determining an optimal SSED through automatic computing. The objective of the model is to minimize the number of shunting movements and the constraints include track occupation conflicts, shunting routes conflicts, time durations of maintenance processes, and shunting running time. An enhanced particle swarm optimization (EPSO) algorithm is proposed to solve the optimization problem. Finally, an empirical study from Shanghai South EMU Depot is carried out to illustrate the model and EPSO algorithm. The optimization results indicate that the proposed method is valid for the SSED problem and that the EPSO algorithm outperforms the traditional PSO algorithm on the aspect of optimality. PMID:27436998

Depot Maintenance: Issues and Options for Reporting on Military Depots

DTIC Science & Technology

2008-05-15

for assessing the balance of public and private sector depot maintenance workload? (3) What issues might Congress wish to consider to enhance reporting...on military depots capabilities or funding allocations of the public sector versus private sector ? This briefing is intended to satisfy the mandate that GAO review 50/50 reporting requirements.

7 CFR 924.6 - Varieties.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Varieties. 924.6 Section 924.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.6 Varieties. Varieties...

7 CFR 924.6 - Varieties.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Varieties. 924.6 Section 924.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.6 Varieties. Varieties...

76 FR 55907 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... to Authorize Grazing Domestic Sheep, Walla Walla Range District of the Umatilla National Forest... Accountability Measures for Caribbean Spiny Lobster, Gulf of Mexico and South Atlantic Regions, Review Period... National Forest, Archuleta, Conejos, Dolores, Hinsdale, LaPlata, Mineral, Montezuma, Montrose, Rio Grande...

7 CFR 924.15 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 924.15 Section 924.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.15 Export. Export means...

40 CFR 49.11014 - Source surveillance. [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Source surveillance. [Reserved] 49.11014 Section 49.11014 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER... Plan for the Confederated Tribes of the Umatilla Reservation, Oregon § 49.11014 Source surveillance...

Detail view of substructure, view looking south at the center ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of substructure, view looking south at the center in-water frame bent - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.

PubMed

Hjortebjerg, Rikke; Berryman, Darlene E; Comisford, Ross; Frank, Stuart J; List, Edward O; Bjerre, Mette; Frystyk, Jan; Kopchick, John J

2017-05-01

Growth hormone (GH) is a determinant of glucose homeostasis and adipose tissue (AT) function. Using 7-month-old transgenic mice expressing the bovine growth hormone (bGH) gene and growth hormone receptor knockout (GHR-/-) mice, we examined whether changes in GH action affect glucose, insulin, and pyruvate tolerance and AT expression of proteins involved in the interrelated signaling pathways of GH, insulinlike growth factor 1 (IGF-1), and insulin. Furthermore, we searched for AT depot-specific differences in control mice. Glycated hemoglobin levels were reduced in bGH and GHR-/- mice, and bGH mice displayed impaired gluconeogenesis as judged by pyruvate tolerance testing. Serum IGF-1 was elevated by 90% in bGH mice, whereas IGF-1 and insulin were reduced by 97% and 61% in GHR-/- mice, respectively. Igf1 RNA was increased in subcutaneous, epididymal, retroperitoneal, and brown adipose tissue (BAT) depots in bGH mice (mean increase ± standard error of the mean in all five depots, 153% ± 27%) and decreased in all depots in GHR-/- mice (mean decrease, 62% ± 4%). IGF-1 receptor expression was decreased in all AT depots of bGH mice (mean decrease, 49% ± 6%) and increased in all AT depots of GHR-/- mice (mean increase, 94% ± 8%). Insulin receptor expression was reduced in retroperitoneal, mesenteric, and BAT depots in bGH mice (mean decrease in all depots, 56% ± 4%) and augmented in subcutaneous, retroperitoneal, mesenteric, and BAT depots in GHR-/- mice (mean increase: 51% ± 1%). Collectively, our findings indicate a role for GH in influencing hormone signaling in AT in a depot-dependent manner. Copyright © 2017 Endocrine Society.

Space Transportation Infrastructure Supported By Propellant Depots

NASA Technical Reports Server (NTRS)

Smitherman, David; Woodcock, Gordon

2012-01-01

A space transportation infrastructure is described that utilizes propellant depot servicing platforms to support all foreseeable missions in the Earth-Moon vicinity and deep space out to Mars. The infrastructure utilizes current expendable launch vehicle (ELV) systems such as the Delta IV Heavy, Atlas V, and Falcon 9, for all crew, cargo, and propellant launches to orbit. Propellant launches are made to Low-Earth-Orbit (LEO) Depot and an Earth-Moon Lagrange Point 1 (L1) Depot to support a new reusable in-space transportation vehicles. The LEO Depot supports missions to Geosynchronous Earth Orbit (GEO) for satellite servicing and to L1 for L1 Depot missions. The L1 Depot supports Lunar, Earth-Sun L2 (ESL2), Asteroid and Mars Missions. New vehicle design concepts are presented that can be launched on current 5 meter diameter ELV systems. These new reusable vehicle concepts include a Crew Transfer Vehicle (CTV) for crew transportation between the LEO Depot, L1 Depot and missions beyond L1; a new reusable lunar lander for crew transportation between the L1 Depot and the lunar surface; and Mars orbital Depot are based on International Space Station (ISS) heritage hardware. Data provided includes the number of launches required for each mission utilizing current ELV systems (Delta IV Heavy or equivalent) and the approximate vehicle masses and propellant requirements. Also included is a discussion on affordability with ideas on technologies that could reduce the number of launches required and thoughts on how this infrastructure include competitive bidding for ELV flights and propellant services, developments of new reusable in-space vehicles and development of a multiuse infrastructure that can support many government and commercial missions simultaneously.

Future Concepts for Integrating the Space Launch System and the Multi-Purpose Crew Vehicle into a Reusable Space Transportation Infrastructure

NASA Technical Reports Server (NTRS)

Smitherman, David; Woodcock, Gordon

2012-01-01

A space transportation infrastructure is described that utilizes the Space Launch System (SLS), the Mulit-Purpose Crew Vehicle (MPCV), the International Space Station (ISS), and propellant depot servicing platforms to support all foreseeable missions in the Earth-Moon vicinity and deep space out to Mars. The infrastructure utilizes current expendable launch vehicle (ELV) systems such as the Delta IV Heavy, Atlas V, and Falcon 9, for commercial crew, cargo, and propellant launches to a Low-Earth-Orbit (LEO) Depot and/or the ISS. The SLS provides all payload and propellant launches to the Earth-Moon Langrange Point 1 (EML1) Depot to support new reusable in-space transportation vehicles. The ISS or follow-on LEO Depot supports missions to Geosynchronous Earth Orbit (GEO) for satellite servicing and to Earth-Moon L1 for EML1 Depot missions. The EML1 Depot supports Lunar, Earth-Sun L2 (ESL2), Asteroid, and Mars missions. New vehicle design concepts are presented that can be launched utilizing the SLS and current ELV systems. These new reusable vehicle concepts include a Crew Transfer Vehicle (CTV) derived from the MPCV and a reusable Cryogenic Propulsion Stage (CPS) for crew transportation between the LEO Depot, EML1 Depot and missions beyond the Earth-Moon vicinity; a new reusable Lunar Lander for crew transportation between the EML1 Depot and the lunar surface; and a new reusable Deep Space Habitat (DSH) with a CTV to support crew missions from the EML1 Depot to ESL2, Asteroids, and a Mars Orbital Depot. The LEO Depot, EML1 Depot, and Mars Orbital Depot are based on International Space Station (ISS) heritage hardware. Data provided includes the number of launches required for each mission utilizing SLS and current ELV systems (Delta IV Heavy or equivalent) and the approximate vehicle masses and propellant requirements. Also included is a discussion on affordability with ideas on technologies that could reduce the number of launches required and thoughts on how this infrastructure might be implemented incrementally over the next few decades. The potential benefits of this infrastructure include competitive bidding for ELV flights and propellant services, development of new reusable in-space vehicles, and development of a robust multiuse infrastructure that can support many government and commercial missions simultaneously.

Topographic view of the North Fork Butter Creek Bridge (located ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Topographic view of the North Fork Butter Creek Bridge (located center of frame), view looking west - North Fork Butter Creek Bridge, Spanning North Fork Butter Creek Bridge at Milepost 76.63 on Heppner Highway (Oregon Route 74), Pilot Rock, Umatilla County, OR

Ligand Depot: a data warehouse for ligands bound to macromolecules.

PubMed

Feng, Zukang; Chen, Li; Maddula, Himabindu; Akcan, Ozgur; Oughtred, Rose; Berman, Helen M; Westbrook, John

2004-09-01

Ligand Depot is an integrated data resource for finding information about small molecules bound to proteins and nucleic acids. The initial release (version 1.0, November, 2003) focuses on providing chemical and structural information for small molecules found as part of the structures deposited in the Protein Data Bank. Ligand Depot accepts keyword-based queries and also provides a graphical interface for performing chemical substructure searches. A wide variety of web resources that contain information on small molecules may also be accessed through Ligand Depot. Ligand Depot is available at http://ligand-depot.rutgers.edu/. Version 1.0 supports multiple operating systems including Windows, Unix, Linux and the Macintosh operating system. The current drawing tool works in Internet Explorer, Netscape and Mozilla on Windows, Unix and Linux.

Cryogenic thermal system analysis for orbital propellant depot

NASA Astrophysics Data System (ADS)

Chai, Patrick R.; Wilhite, Alan W.

2014-09-01

In any manned mission architecture, upwards of seventy percent of all payload delivered to orbit is propellant, and propellant mass fraction dominates almost all transportation segments of any mission requiring a heavy lift launch system like the Saturn V. To mitigate this, the use of an orbital propellant depot has been extensively studied. In this paper, a thermal model of an orbital propellant depot is used to examine the effects of passive and active thermal management strategies. Results show that an all passive thermal management strategy results in significant boil-off for both hydrogen and oxygen. At current launch vehicle prices, these boil-offs equate to millions of dollars lost per month. Zero boil-off of propellant is achievable with the use of active cryocoolers; however, the cooling power required to produce zero-boil-off is an order of magnitude higher than current state-of-the-art cryocoolers. This study shows a zero-boil-off cryocooler minimum power requirement of 80-100 W at 80 K for liquid oxygen, and 100-120 W at 20 K for liquid hydrogen for a representative Near-Earth Object mission. Research and development effort is required to improve the state-of-the-arts in-space cryogenic thermal management.

Thermogenic profiling using magnetic resonance imaging of dermal and other adipose tissues

PubMed Central

Kasza, Ildiko; Hernando, Diego; Roldán-Alzate, Alejandro; Alexander, Caroline M.; Reeder, Scott B.

2016-01-01

Dermal white adipose tissue (dWAT) was recently recognized for its potential to modify whole body metabolism. Here, we show that dWAT can be quantified using a high-resolution, fat-specific magnetic resonance imaging (MRI) technique. Noninvasive MRI has been used to describe adipocyte depots for many years; the MRI technique we describe uses an advanced fat-specific method to measure the thickness of dWAT, together with the total volume of WAT and the relative activation/fat depletion of brown adipose tissues (BAT). Since skin-embedded adipocytes may provide natural insulation, they provide an important counterpoint to the activation of thermogenic brown and beige adipose tissues, whereby these distinct depots are functionally interrelated and require simultaneous assay. This method was validated using characterized mouse cohorts of a lipodystrophic, dWAT-deficient strain (syndecan-1 KO) and 2 obese models (diet-induced obese mice and genetically obese animals, ob/ob). Using a preliminary cohort of normal human subjects, we found the thickness of skin-associated fat varied 8-fold, from 0.13–1.10 cm; on average, this depot is calculated to weigh 8.8 kg. PMID:27668285

Motion of Euglena gracilis: Active fluctuations and velocity distribution

NASA Astrophysics Data System (ADS)

Romanczuk, P.; Romensky, M.; Scholz, D.; Lobaskin, V.; Schimansky-Geier, L.

2015-07-01

We study the velocity distribution of unicellular swimming algae Euglena gracilis using optical microscopy and active Brownian particle theory. To characterize a peculiar feature of the experimentally observed distribution at small velocities we use the concept of active fluctuations, which was recently proposed for the description of stochastically self-propelled particles [Romanczuk, P. and Schimansky-Geier, L., Phys. Rev. Lett. 106, 230601 (2011)]. In this concept, the fluctuating forces arise due to internal random performance of the propulsive motor. The fluctuating forces are directed in parallel to the heading direction, in which the propulsion acts. In the theory, we introduce the active motion via the depot model [Schweitzer, et al., Phys. Rev. Lett. 80(23), 5044 (1998)]. We demonstrate that the theoretical predictions based on the depot model with active fluctuations are consistent with the experimentally observed velocity distributions. In addition to the model with additive active noise, we obtain theoretical results for a constant propulsion with multiplicative noise.

A Genetically Engineered Thermally Responsive Sustained Release Curcumin Depot to Treat Neuroinflammation

PubMed Central

Sinclair, S. Michael; Bhattacharyya, Jayanta; McDaniel, Jonathan R.; Gooden, David M.; Gopalaswamy, Ramesh; Chilkoti, Ashutosh; Setton, Lori A.

2014-01-01

Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists for radiculopathy in the clinic has shown mixed results, and there is growing interest in the local delivery of anti-inflammatory drugs to treat this pathology as well as similar inflammatory events of peripheral nerve injury. Curcumin, a known antagonist of TNFα in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation. ELPs are biopolymers capable of thermally-triggered in situ depot formation that have been successfully employed as drug carriers and biomaterials in several applications. ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFα-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin. When injected proximal to the sciatic nerve in mice via intramuscular (i.m.) injection, ELP-curcumin conjugates underwent a thermally triggered soluble-insoluble phase transition, leading to in situ formation of a depot that released curcumin over 4 days post-injection and decreased plasma AUC 7-fold. PMID:23830979

77 FR 29636 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

..., Implementation, Paulina Ranger District, Ochoco National Forest, Crook and Wheeler Counties, OR, Review Period... Improve Health and Vigor Upland Forest Stands and Reduce Hazardous and Ladder Fuels, Walla Walla Ranger District, Umatilla National Forest, Wallowa and Union Counties, OR, Review Period Ends: 06/18/2012, Contact...

Umatilla River Fish Passage Operations Project : Annual Progress Report October 2007 - September 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bronson, James P.; Loffink, Ken; Duke, Bill

Threemile Falls Dam (Threemile Dam), located near the town of Umatilla, is the major collection and counting point for adult salmonids returning to the Umatilla River. Returning salmon and steelhead were enumerated at Threemile Dam from June 7, 2007 to August 11, 2008. A total of 3,133 summer steelhead (Oncorhynchus mykiss); 1,487 adult, 1,067 jack, and 999 subjack fall Chinook (O. tshawytscha); 5,140 adult and 150 jack coho (O. kisutch); and 2,009 adult, 517 jack, and 128 subjack spring Chinook (O. tshawytscha) were counted. All fish were enumerated at the east bank facility. Of the fish counted, 1,442 summer steelheadmore » and 88 adult and 84 jack spring Chinook were hauled upstream from Threemile Dam. There were 1,497 summer steelhead; 609 adult, 1,018 jack and 979 subjack fall Chinook; 5,036 adult and 144 jack coho; and 1,117 adult, 386 jack and 125 subjack spring Chinook either released at, or allowed to volitionally migrate past, Threemile Dam. Also, 110 summer steelhead; 878 adult and 43 jack fall Chinook; and 560 adult and 28 jack spring Chinook were collected as broodstock for the Umatilla River hatchery program. In addition, there were 241 adult and 15 jack spring Chinook collected at Threemile Dam for outplanting in the South Fork Walla Walla River and Mill Cr, a tributary of the mainstem Walla Walla River. The Westland Canal juvenile facility (Westland), located near the town of Echo at river mile (RM) 27, is the major collection point for out-migrating juvenile salmonids and steelhead kelts. The canal was open for 158 days between February 11, 2008 and July 18, 2008. During that period, fish were bypassed back to the river 150 days and were trapped 6 days. There were also 2 days when fish were directed into and held in the canal forebay between the time the bypass was closed and the trap opened. An estimated 64 pounds of fish were transported from the Westland trapping facility. Approximately 25.8% of the fish transported were salmonids. In addition, one adult Pacific lamprey was trapped and released above the Westland ladder this year. The Threemile Dam west bank juvenile bypass was opened on March 11, 2008 in conjunction with water deliveries and continued through the summer. West Extension Irrigation District (WEID) discontinued diverting live flow on June 24, 2008 but the bypass remained open throughout the project year. The juvenile trap was not operated this project year.« less

Perspective view of the Oregon Trunk Railway Freight Depot, view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Perspective view of the Oregon Trunk Railway Freight Depot, view looking west at south end of building - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE (HAER No. PA-116). - Philadelphia & Reading Railroad, Reading Depot Bridge, North Sixth Street at Woodward Street, Reading, Berks County, PA

48 CFR 47.208-1 - Advance notice.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... Military (and as required, civilian agency) storage and distribution points, depots, and other receiving activities require advance notice of shipments en route from contractors' plants. Generally, this...

Implementation of Geographical Information System for Bacteriological Contamination Analysis on Refill Drinking Water Depot (Study in Tembalang District)

NASA Astrophysics Data System (ADS)

Rahmitha, Amelia; Utami, Endang Sri; Sitohang, Marya Yenita

2018-02-01

People used refilled-drinking-water for household and food stall because its efficient and low cost. Based on Indonesian Health Ministry regulation, it should not have any coliform bacteria. This study aimed to describe the bacteriological contamination of refilled drinking water using geographical information system (GIS). In this research, it was used an analytic observational method. The samples were from all available (37) depots in Tembalang district, one form each depot took used a sterile bottle. Contamination of bacteria was identified by Most Probable Number (MPN) method lactose broth media, Mac Conkey media, and IMVIC media. The depot samples were then plotted on (GIS). This study showed 95% samples were not feasible to consume since they contamined coliform. All sub-district had one that contaminated by coliform, 75% sub-districts had depots that contaminated Escherichia coli, while 55% sub-districts had depots that contaminated with other bacteria. The internal risk factors of the contamination were the absence of hygiene-sanitation worthy certificate (95%), depots location near to pollution sources (5%), and the misused of UV light. The external risk factor was lack of quality control that was not as the sterilization from office health Semarang city. Policy reinforcement should be done to all of the depots.

Cosolvent effects on the drug release and depot swelling in injectable in situ depot-forming systems.

PubMed

Liu, Hui; Venkatraman, Subbu S

2012-05-01

Although injectable depot-forming solutions have been commercialized, the factors that influence the overall release kinetics from such systems are still not fully understood. In this work, we address the effect of cosolvent on the issue of excessive burst release of potent bioactives from injectable depot-forming solutions. Specifically, we have evaluated the influence of addition of a relatively hydrophobic cosolvent (triacetin) to more hydrophilic biocompatible solvents such as dimethyl sulfoxide (DMSO) and N-methyl-2-pyrrolidone (NMP) on the burst release. Drug release and solvent release results demonstrate that high burst release that occurred when only hydrophilic solvent was used as solvent was significantly reduced by adding triacetin as a cosolvent. The profiles of drug release were in good agreement with the profiles of the hydrophilic solvent DMSO or NMP release, and the suppression of the burst by triacetin addition is due to the suppression of the solvent release. Surprisingly, the swelling of the depot increased with triacetin amount and the depot morphology became more porous compared with the absence of triacetin. Usage of hydrophobic solvent as a cosolvent to reduce the burst release was shown to be more effective on the hydrophobic PdlLA depot and less effective on the relatively hydrophilic RG502 depot. Copyright © 2012 Wiley Periodicals, Inc.

Active Brown Fat During 18F-FDG PET/CT Imaging Defines a Patient Group with Characteristic Traits and an Increased Probability of Brown Fat Redetection.

PubMed

Gerngroß, Carlos; Schretter, Johanna; Klingenspor, Martin; Schwaiger, Markus; Fromme, Tobias

2017-07-01

Brown adipose tissue (BAT) provides a means of nonshivering thermogenesis. In humans, active BAT can be visualized by 18 F-FDG uptake as detected by PET combined with CT. The retrospective analysis of clinical scans is a valuable source to identify anthropometric parameters that influence BAT mass and activity and thus the potential efficacy of envisioned drugs targeting this tissue to treat metabolic disease. Methods: We analyzed 2,854 18 F-FDG PET/CT scans from 1,644 patients and identified 98 scans from 81 patients with active BAT. We quantified the volume of active BAT depots (mean values in mL ± SD: total BAT, 162 ± 183 [ n = 98]; cervical, 40 ± 37 [ n = 53]; supraclavicular, 66 ± 68 [ n = 71]; paravertebral, 51 ± 53 [ n = 69]; mediastinal, 43 ± 40 [ n = 51]; subphrenic, 21 ± 21 [ n = 29]). Because only active BAT is detectable by 18 F-FDG uptake, these numbers underestimate the total amount of BAT. Considering only 32 scans of the highest activity as categorized by a visual scoring strategy, we determined a mean total BAT volume of 308 ± 208 mL. In 30 BAT-positive patients with 3 or more repeated scans, we calculated a much higher mean probability to redetect active BAT (52% ± 25%) as compared with the overall prevalence of 4.9%. We calculated a BAT activity index (BFI) based on volume and intensity of individual BAT depots. Results: We detected higher total BFI in younger patients ( P = 0.009), whereas sex, body mass index, height, mass, outdoor temperature, and blood parameters did not affect total or depot-specific BAT activity. Surprisingly, renal creatinine clearance as estimated from mass, age, and plasma creatinine was a significant predictor of BFI on the total ( P = 0.005) as well as on the level of several individual depots. In summary, we detected a high amount of more than 300 mL of BAT tissue. Conclusion: BAT-positive patients represent a group with a higher than usual probability to activate BAT during a scan. Estimated renal creatinine clearance correlated with the extent of activated BAT in a given scan. These data imply an efficacy of drugs targeting BAT to treat metabolic disease that is at the same time higher and subject to a larger individual variation than previously assumed. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

A diet high in fat stimulates adipocyte proliferation in older (22 month) rats.

PubMed

Ellis, J R; McDonald, R B; Stern, J S

1990-01-01

The effect of a high fat diet in stimulating adipocyte proliferation, as measured by the incorporation of [3H]-thymidine into fat cell DNA, was studied in 22-month-old female Sprague-Dawley rats. Rats were fed a low fat (n = 10) or a high fat diet (n = 9) for a total of six days. On days 4 and 5 of dietary manipulation, rats were injected with 80 microCi/100 g body weight of [3H]-thymidine. Rats were continued on their respective diets for one more day, starved for 72 h and then refed a stock diet for three weeks in order to increase turnover of stroma cells, thus diluting the specific activity of stromal DNA with minimal effect on specific activity of fat cell DNA. The diet groups did not differ significantly with respect to body masses, food intake, parametrial (PARA) and retroperitoneal (RP) depot masses, cell number or cell size. The specific activity of DNA in both PARA and RP depots was greater in the adipocyte than in the stromavascular fraction. Specific activity of fat cells was significantly greater from rats fed the high fat than the low fat diet in both PARA and RP depots. Radioautography of adipose tissue confirmed that there was a greater percentage of adipocyte nuclei labeled in the rats fed the high fat diet. Also, there were few labeled nuclei found in stroma cells. In conclusion, older female rats increased adipocyte proliferation when fed a high fat diet.

Detail perspective view of the Oregon Trunk Railway Freight Depot, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail perspective view of the Oregon Trunk Railway Freight Depot, view looking east at south end of building - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. Philadelphia ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. LOOKING NW, WITH READING DEPOT IN BACKGROUND. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

CCP Billing Alternatives Study

DOT National Transportation Integrated Search

1996-04-01

On behalf of DoD, the Defense Logistics Agency operates consolidation and containerization points (CCPs) at Defense Depot Susquehanna, PA and at Defense Depot San Joaquin, CA. These CCPs receive freight from other defense depots and consolidate it in...

7 CFR 924.30 - Powers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Powers. 924.30 Section 924.30 Agriculture Regulations... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Administrative Body § 924.30 Powers. The committee shall have the following powers: (a) To administer the provisions of this part in accordance with...

The western juniper resource of eastern Oregon, 1999.

Treesearch

David L. Azuma; Bruce A. Hiserote; Paul A. Dunham

2005-01-01

This report summarizes resource statistics for eastern Oregon's juniper forests, which are in Baker, Crook, Deschutes, Gilliam, Grant, Harney, Jefferson, Klamath, Lake, Malheur, Morrow, Sherman, Umatilla, Union, Wallowa, Wasco, and Wheeler Counties. We sampled all ownerships outside of the National Forest System; we report the statistics on juniper forest on...

7 CFR 924.30 - Powers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Powers. 924.30 Section 924.30 Agriculture Regulations... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Administrative Body § 924.30 Powers. The committee shall have the following powers: (a) To administer the provisions of this part in accordance with...

Estimating the avoided fuel-reatment costs of wildfire

Treesearch

Geoffrey H. Donovan; Thomas C. Brown

2008-01-01

Although the importance of wildfire to fire-adapted ecosystems is widely recognized, wildfire management has historically placed less emphasis on the beneficial effects of wildfire. We estimate the avoided fuel treatment cost for 10 ponderosa pine (Pinus ponderosa) stands on the Umatilla National Forest in the Pacific Northwest. Results show that...

7 CFR 924.1 - Secretary.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Secretary. 924.1 Section 924.1 Agriculture Regulations... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.1 Secretary. Secretary means the Secretary of Agriculture of the United States, or any officer or employee of the Department to...

7 CFR 924.1 - Secretary.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Secretary. 924.1 Section 924.1 Agriculture Regulations... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.1 Secretary. Secretary means the Secretary of Agriculture of the United States, or any officer or employee of the Department to...

75 FR 15403 - Plan Revision for Malheur, Umatilla and Wallowa-Whitman National Forests, Oregon and Washington...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-29

... and sometimes extended drought, climate change, increasing vegetative density, shifts in forest...; moderating floods; and maintaining reliable stream flows for downstream users. 4. To address climate change. The 1990 forest plans do not address climate change. Climate change is expected to [[Page 15405...

7 CFR 924.142 - Reserve fund.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Reserve fund. 924.142 Section 924.142 Agriculture... COUNTIES IN WASHINGTON AND IN UMATILLA COUNTY, OREGON Rules and Regulations § 924.142 Reserve fund. (a) The establishment of a reserve fund of an amount which shall not exceed approximately one fiscal year's operational...

Timber resource statistics for eastern Oregon, 1999.

Treesearch

David L. Azuma; Paul A. Dunham; Bruce A. Hiserote; Charles F. Veneklase

2004-01-01

This report is a summary of timber resource statistics for eastern Oregon, which includes Baker, Crook, Deschutes, Gilliam, Grant, Harney, Jefferson, Klamath, Lake, Malheur, Morrow, Sherman, Umatilla, Union, Wallowa, Wasco, and Wheeler Counties. Data were collected as part of a statewide multiresource inventory. The inventory sampled all private and public lands except...

Partial elevation view of the Oregon Trunk Railway Freight Depot, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Partial elevation view of the Oregon Trunk Railway Freight Depot, view looking west at south end of east façade - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

Partial elevation view of the Oregon Trunk Railway Freight Depot, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Partial elevation view of the Oregon Trunk Railway Freight Depot, view looking west at north end of east façade - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

Partial elevation view of the Oregon Trunk Railway Freight Depot, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Partial elevation view of the Oregon Trunk Railway Freight Depot, view looking west at center of east façade - Oregon Trunk Railway Freight Depot, Southwest First Street & Cascade Avenue, Redmond, Deschutes County, OR

Evidence for Environmental Contamination in Residential Neighborhoods Surrounding the Defense Depot of Memphis, Tennessee

PubMed Central

Greene, Natasha A.; White, Jason D.; Morris, Vernon R.; Roberts, Stephanie; Jones, Kimberly L.; Warrick, Cynthia

2006-01-01

An interdisciplinary environmental assessment team from the Howard University Environmental Justice Partnership (HUEJP) conducted a site visit and assessment of the Defense Depot of Memphis, Tennessee in February of 2000. This depot was built in the late 1940’s for storage of numerous chemicals and munitions. As the years progressed, many Memphis citizens have grown to believe that the activities and chemical stockpile located at this site have negatively affected the health environment of their residents. There is anecdotal evidence and documentation of numerous cancers and other illnesses in those local territories, and specifically, at the Memphis Depot site. Currently, this depot is closed and in remediation by the local government. Particularly, citizens of the Rozelle community have started a campaign to investigate any signs of exposure pathways to noted health risks. The HUEJP was contacted and asked to investigate the community concerns. Obliging to the request, we aimed to sample at three drainage sites and a residential site, talk to local citizens, and gain any additional information that would be helpful in relieving anxiety in the Rozelle community. Soil, sediment, and water samples were collected and analyzed for total organic carbon, inorganic anions, and heavy metals. These data show that for the four sites sampled, the highest concentrations of organic compounds and heavy metals were located either within a residential area or in an area with a direct transport pathway to the community. Atomic absorption analysis revealed detectable amounts of cadmium, lead and chromium metals at all sites with direct transport pathways into the residential community, with chromium concentrations being far in excess of the EPA standard limits. PMID:16968970

Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty.

PubMed

Carel, Jean-Claude; Blumberg, Joëlle; Seymour, Christine; Adamsbaum, Catherine; Lahlou, Najiba

2006-01-01

Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP. This was a multicenter, open-label, 12 month trial conducted in 64 CPP children (54 girls and 10 boys), treated quarterly. Children with a clinical onset of pubertal development before the age of 8 years (girls) or 9 years (boys), pubertal response of LH to GnRH > or = 7 IU/l, advanced bone age > 1 year, enlarged uterus (> or = 36 mm) and testosterone level > or = 0.5 ng/ml (boys), were included. Suppression of gonadotropic activation, as determined from serum LH, FSH, estradiol or testosterone, and pubertal signs were assessed at Months 3, 6 and 12. GnRH-stimulated peak LH < or = 3 IU/l, the main efficacy criterion, was met in 53 out of 62 (85%), 60 out of 62 (97%) and 56 out of 59 (95%) of the children at Months 3, 6 and 12 respectively. Serum FSH and sex steroids were also significantly reduced, while pubertal development regressed in most patients. Mean residual triptorelin levels were stable from Month 3 through to Month 12. The triptorelin 3-month depot was well tolerated. Severe injection pain was experienced in only one instance. Five girls experienced mild-to-moderate or severe (one girl) withdrawal bleeding. The triptorelin 3-month depot efficiently suppresses the pituitary-gonadal axis and pubertal development in children with CPP. This formulation allows a 3-fold reduction, over the once-a-month depot, in the number of i.m. injections required each year.

1. OVERVIEW, LOOKING EAST OF SIDE ELEVATION OF THE DEPOT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. OVERVIEW, LOOKING EAST OF SIDE ELEVATION OF THE DEPOT (RIGHT) WHICH SERVES AS THE HEART OF DIXIE RAILROAD MUSEUM. AT LEFT IS HISTORIC RAILROAD ROLLING STOCK FROM THE MUSEUM'S COLLECTIONS. - Wilton Depot, Ninth Street, Calera, Shelby County, AL

11-Hydroxy-β-steroid dehydrogenase gene expression in canine adipose tissue and adipocytes: stimulation by lipopolysaccharide and tumor necrosis factor α.

PubMed

Ryan, V H; Trayhurn, P; Hunter, L; Morris, P J; German, A J

2011-10-01

The enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD-1) is expressed in a number of tissues in rodents and humans and is responsible for the reactivation of inert cortisone into cortisol. Its gene expression and activity are increased in white adipose tissue (WAT) from obese humans and may contribute to the adverse metabolic consequences of obesity and the metabolic syndrome. The extent to which 11β-HSD-1 contributes to adipose tissue function in dogs is unknown; the aim of the present study was to examine 11β-HSD-1 gene expression and its regulation by proinflammatory and anti-inflammatory agents in canine adipocytes. Real-time PCR was used to examine the expression of 11β-HSD-1 in canine adipose tissue and canine adipocytes differentiated in culture. The mRNA encoding 11β-HSD-1 was identified in all the major WAT depots in dogs and also in liver, kidney, and spleen. Quantification by real-time PCR showed that 11β-HSD-1 mRNA was least in perirenal and falciform depots and greatest in subcutaneous, omental, and gonadal depots. Greater expression was seen in the omental depot in female than in male dogs (P=0.05). Gene expression for 11β-HSD-1 was also seen in adipocytes, from both subcutaneous and visceral depots, differentiated in culture; expression was evident throughout differentiation but was generally greatest in preadipocytes and during early differentiation, declining as cells progressed to maturity. The inflammatory mediators lipopolysaccharide and tumor necrosis factor α had a main stimulatory effect on 11β-HSD-1 gene expression in canine subcutaneous adipocytes, but IL-6 had no significant effect. Treatment with dexamethasone resulted in a significant time- and dose-dependent increase in 11β-HSD-1 gene expression, with greatest effects seen at 24 h (2 nM: approximately 4-fold; 20 nM: approximately 14-fold; P=0.010 for both). When subcutaneous adipocytes were treated with the peroxisome proliferator activated receptor γ agonist rosiglitazone, similar dose- and time-dependent effects were noted. However, no effects were seen when adipocytes from the gonadal WAT depot were treated with rosiglitazone. The induction of 11β-HSD-1 expression, by the pro-inflammatory cytokine tumor necrosis factor α and by lipopolysaccharide may have implications for the pathogenesis of obesity and its associated diseases in the dog. Copyright © 2011 Elsevier Inc. All rights reserved.

Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo.

PubMed

De Sousa Peixoto, R A; Turban, S; Battle, J H; Chapman, K E; Seckl, J R; Morton, N M

2008-04-01

Glucocorticoid excess promotes visceral obesity and cardiovascular disease. Similar features are found in the highly prevalent metabolic syndrome in the absence of high levels of systemic cortisol. Although elevated activity of the glucocorticoid-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) within adipocytes might explain this paradox, the potential role of 11beta-HSD1 in preadipocytes is less clear; human omental adipose stromal vascular (ASV) cells exhibit 11beta-dehydrogenase activity (inactivation of glucocorticoids) probably due to the absence of cofactor provision by hexose-6-phosphate dehydrogenase. To clarify the depot-specific impact of 11beta-HSD1, we assessed whether preadipocytes in ASV from mesenteric (as a representative of visceral adipose tissue) and sc tissue displayed 11beta-HSD1 activity in mice. 11beta-HSD1 was highly expressed in freshly isolated ASV cells, predominantly in preadipocytes. 11beta-HSD1 mRNA and protein levels were comparable between ASV and adipocyte fractions in both depots. 11beta-HSD1 was an 11beta-reductase, thus reactivating glucocorticoids in ASV cells, consistent with hexose-6-phosphate dehydrogenase mRNA expression. Unexpectedly, glucocorticoid reactivation was higher in intact mesenteric ASV cells despite a lower expression of 11beta-HSD1 mRNA and protein (homogenate activity) levels than sc ASV cells. This suggests a novel depot-specific control over 11beta-HSD1 enzyme activity. In vivo, high-fat diet-induced obesity was accompanied by increased visceral fat preadipocyte differentiation in wild-type but not 11beta-HSD1(-/-) mice. The results suggest that 11beta-HSD1 reductase activity is augmented in mouse mesenteric preadipocytes where it promotes preadipocyte differentiation and contributes to visceral fat accumulation in obesity.

Potential hazards from hygiene, sanitation and bacterium of refill drinking water at Barrang Lompo island (water and food safety perspective)

NASA Astrophysics Data System (ADS)

Birawida, A. B.; Selomo, M.; Mallongi, A.

2018-05-01

Coliform bacteria are suspected to come from faeces. As a result, their presence in various places ranging from drinking water, foodstuffs or other ingredients to human needs are not expected. This research aimed to describe bacterial contaminations, depot sanitations, equipment sanitations, worker hygiene, raw water quality, and refill drinking water in Barrang Lompo island in 2017. The observational research applied descriptive approach. Water samples collected grab from the drinking water depot taps, then examined using Most Probable Number (MPN) method. The results showed that three of six depots have qualified drinking water quality. Raw water samples from all depots indicated that none were eligible. The samples examined contained gram-negative bacteria. The types of bacteria that grew on the sample were Klebsiella pneumonia and Pseudomonas aerogenosa. In the environmental sanitation depots and worker hygiene, there was no one eligible. Sanitary appliances were all eligible and there were depots that used reserve osmosis methods and used combination methods between reserve osmosis and ultraviolet light. It was concluded that almost all samples of drinking water were contaminated by bacteria. Owners and depot workers were advised to improve and implement better hygiene and sanitation.

Evaluation of Uniform Cost Accounting System to Fully Capture Depot Level Repair Costs.

DTIC Science & Technology

1985-12-01

RD-RI65 522 EVALUATION OF UNIFORM COST ACCOUNTING SYSTEM TO FULLY i/I CAPTURE DEPOT LEVEL REPAIR COSTS (U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA D R...8217.LECTE B ,- THESIS EVALUATION OF UNIFORM COST ACCOUNTING SYSTEM 0TO FULLY CAPTURE DEPOT LEVEL REPAIR COSTS Jby __jDavid Richmond O’Brien lj,,, December...Include Security Classification) EVALUATION OF UNIFORM COST ACCOUNTING SYSTEM TO FULLY CAPTURE DEPOT LEVEL REPAIR COSTS 12 PERSONAL AUTHOR(S) O’Brien- David

Switching away from pipotiazine palmitate: a naturalistic study.

PubMed

Mustafa, Feras Ali

2017-01-01

In March 2015, pipotiazine palmitate depot antipsychotic was globally withdrawn due to the shortage of its active ingredient. Thus, all patients receiving this medication had to be switched to an alternative antipsychotic drug. In this study we set to evaluate the process of switching away from pipotiazine palmitate within our clinical service, and its impact on hospitalization. Demographic and clinical data on patients who were receiving pipotiazine palmitate in Northamptonshire at the time of its withdrawal were anonymously extracted from their electronic records and analyzed using descriptive statistics. A total of 17 patients were switched away from pipotiazine palmitate at the time of its withdrawal, all of whom had a prior history of nonadherence with oral treatment. A total of 14 patients were switched to another depot antipsychotic drug, while three patients chose an oral alternative which they subsequently discontinued resulting in relapse and hospitalization. There was a five-fold increase in mean hospitalization among patients who completed a year after the switch. Switching away from pipotiazine palmitate was associated with significant clinical deterioration in patients who switched to an oral antipsychotic, whereas most patients who switched to another depot treatment maintained stability. Clinicians should exercise caution when switching patients with schizophrenia away from depot antipsychotic drugs, especially in cases of patients with a history of treatment nonadherence who prefer to switch to oral antipsychotics.

[Chemical castration using a depot LHRH-agonist as a palliative therapy concept in prostatic carcinoma--clinical, endocrinological and experimental studies].

PubMed

Kuber, W; Treu, T; Kratzik, C; Girsch, E; Zeillinger, R; Spona, J

1990-11-09

79 patients with locally advanced and/or metastatic prostate cancer were treated by means of a biodegradeable depot formulation of the luteinizing hormone releasing hormone analogue Goserelin (Zoladex). All patients received 3.6 mg depot Goserelin (Zoladex 3.6 mg implantate) subcutaneously into the anterior abdominal wall at 4 weekly intervals. The average time of observation was 24.2 months. The best objective response rate was found in 62%. Serum testosterone levels initially increased after the first depot injection and then decreased ultimately to castrate range (less than 0.6 ng/ml) between day 15 and day 27 (median 21) in the majority of patients. Castrate testosterone levels were still found 48 months after the start of treatment with depot Goserelin. 6 months after institution of treatment in 66.7% of cases evident signs of histological regression were found in the primary tumour tissue. Adenocarcinoma presented with a highly significantly better response pattern than anaplastic carcinoma. In animal experiments a single dose of 1 mg depot Goserelin was administered to adult male rats and the effect on serum testosterone levels and target organs (testes and ventral prostate) were investigated. Mean testosterone levels (mean = 0.31 ng/ml) decreased to castrate range (less than 0.3 ng/ml). 4 weeks after depot injection weight of the testes and prostate weight were significantly reduced. However 8 weeks after administration of 1 mg depot Goserelin there was no significant between the control group and the treated group. We conclude that the depot formulation of Goserelin (Zoladex) is effective, simple, practicable and safe in the treatment of advanced prostatic cancer. Current clinical studies are confirming the importance of reversible medical castration by LHRH agonists before radical prostatectomy.

Drilling and testing of well 340, Fort Wingate Army Depot, McKinley County, New Mexico

USGS Publications Warehouse

Shomaker, John W.

1969-01-01

The U.S. Geological Survey was requested by Fort Wingate Army Depot to designate a well location, suggest construction and testing procedures, and provide continuing technical advice with respect to the drilling of a new production well. The location was determined during a brief preliminary study of the Depot's water supply which is summarized in a report transmitted to the Depot in April of 1968, and the Geological Survey's suggestions for construction and testing are contained in the specifications written by the Post Engineer at the Depot as part of the well-drilling contract. A representative of the the Geological Survey was present during most of the drilling and testing of the well.

75 FR 5941 - Umatilla National Forest, Walla Walla Ranger District, Walla Walla, WA; Cobbler II Timber Sale...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

... construction (that will be decommissioned after project use), new road construction, danger tree removal along... increasing population. Late seral tree species have become dominant after long periods without disturbance... and vigor. Timber stands of seral tree species such as western larch and ponderosa pine are infilling...

76 FR 41284 - Cold Springs and McKay Creek National Wildlife Refuges, Umatilla County, OR; Comprehensive...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... water remain. A mix of several distinct habitat types--open water, riparian, shrub-steppe upland, and... resting. The shrub-steppe upland consists of sagebrush, bitterbrush, rabbitbrush, and native bunchgrasses... species; management for long-term viability of riparian habitat; providing benefits to shrub-steppe or...

75 FR 43039 - Fresh Prunes Grown in Designated Counties in Washington and in Umatilla County, OR; Suspension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-23

... marketing research and development projects, as well as the necessary reporting and recordkeeping functions... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 924 [Doc. No. AMS-FV-10-0054...; Suspension of Reporting and Assessment Requirements AGENCY: Agricultural Marketing Service, USDA. ACTION...

76 FR 57731 - Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

... Competing Applications; McKay Dam Hydropower, LLC On May 31, 2011, McKay Dam Hydropower, LLC filed an... study the feasibility of the McKay Dam Hydroelectric Project (project) to be located at the McKay dam near Pendleton in Umatilla County, [[Page 57732

7 CFR 924.236 - Assessment rate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 924.236 Section 924.236 Agriculture... COUNTIES IN WASHINGTON AND IN UMATILLA COUNTY, OREGON Assessment Rate § 924.236 Assessment rate. On or after April 1, 2009, an assessment rate of $2.00 per ton is established for the Washington-Oregon Fresh...

7 CFR 924.236 - Assessment rate.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 924.236 Section 924.236 Agriculture... COUNTIES IN WASHINGTON AND IN UMATILLA COUNTY, OREGON Assessment Rate § 924.236 Assessment rate. On or after April 1, 2009, an assessment rate of $2.00 per ton is established for the Washington-Oregon Fresh...

Climate change vulnerability and adaptation in the Blue Mountains

Treesearch

Jessica E. Halofsky; David L. Peterson

2017-01-01

The Blue Mountains Adaptation Partnership was developed to identify climate change issues relevant to resource management in the Blue Mountains region, to find solutions that can minimize negative effects of climate change, and to facilitate transition of diverse ecosystems to a warmer climate. Partnering organizations included three national forests (Malheur, Umatilla...

76 FR 21618 - Fresh Prunes Grown in Designated Counties in Washington and in Umatilla County, OR; Termination...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... with this rule. A small business guide on complying with fruit, vegetable, and specialty crop marketing... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 924 [Docket No. AMS-FV-10-0053...; Termination of Marketing Order 924 AGENCY: Agricultural Marketing Service, USDA. ACTION: Final rule...

40 CFR 49.11021 - Permits for general open burning, agricultural burning, and forestry and silvicultural burning.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Permits for general open burning, agricultural burning, and forestry and silvicultural burning. 49.11021 Section 49.11021 Protection of... Tribes of the Umatilla Reservation, Oregon § 49.11021 Permits for general open burning, agricultural...

40 CFR 49.11021 - Permits for general open burning, agricultural burning, and forestry and silvicultural burning.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Permits for general open burning, agricultural burning, and forestry and silvicultural burning. 49.11021 Section 49.11021 Protection of... Tribes of the Umatilla Reservation, Oregon § 49.11021 Permits for general open burning, agricultural...

40 CFR 49.11021 - Permits for general open burning, agricultural burning, and forestry and silvicultural burning.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Permits for general open burning, agricultural burning, and forestry and silvicultural burning. 49.11021 Section 49.11021 Protection of... Tribes of the Umatilla Reservation, Oregon § 49.11021 Permits for general open burning, agricultural...

40 CFR 49.11021 - Permits for general open burning, agricultural burning, and forestry and silvicultural burning.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Permits for general open burning, agricultural burning, and forestry and silvicultural burning. 49.11021 Section 49.11021 Protection of... Tribes of the Umatilla Reservation, Oregon § 49.11021 Permits for general open burning, agricultural...

76 FR 62758 - Wallowa-Whitman and Umatilla National Forests, Oregon Granite Creek Watershed Mining Plans

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... Granite Creek Watershed Mining Plans AGENCY: Forest Service, USDA. ACTION: Notice of intent to prepare an... to authorize the approval of mining Plans of Operation in the Granite Creek Watershed Mining Plans... environmental analyses for proposed mining Plans in the portions of the Granite Creek Watershed under their...

77 FR 10551 - Confederated Tribes of the Umatilla Indian Reservation-Amendment to Liquor Code

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

..., which is commonly produced by the fermentation or distillation of grain, starch, molasses, or sugar, or... weight. 8. ``Wine''. Any alcoholic beverage obtained by fermentation of fruits, grapes, berries, or any... before, during or after fermentation, and containing not more than seventeen percent (17%) of alcohol by...

The role of remotely sensed and other spatial data for predictive modeling: the Umatilla, Oregon example

USGS Publications Warehouse

Loveland, Thomas R.; Johnson, Gary E.

1981-01-01

The U. S. Geological Survey's Earth Resources Observations Systems Data Center, in cooperation with the U.S. Army Corps of Engineers, Portland District, developed and tested techniques that used remotely sensed and other spatial data in predictive models to evaluate irrigation agriculture in the Umatilla River Basin of north-central Oregon. Landsat data and 1:24,000-scale aerial photographs were initially used to map he expansion of irrigate from 1973 to 1979 and to identify crops under irrigation in 1979. The crop data were then used with historical water requirement figures and digital topographic and hydrographic data to estimate water and power use for the 1979 irrigation season. The final project task involved production of a composite map of land suitability for irrigation development based on land cover (from Landsat), land-ownership, soil irrigability, slope gradient, and potential energy costs. The methods and data used in the study demonstrated the flexibility of remotely sensed and other spatial data as input for predictive models. When combined, they provided useful answers to complex questions facing resource managers.

Epigenetic regulation of depot-specific gene expression in adipose tissue.

PubMed

Gehrke, Sandra; Brueckner, Bodo; Schepky, Andreas; Klein, Johannes; Iwen, Alexander; Bosch, Thomas C G; Wenck, Horst; Winnefeld, Marc; Hagemann, Sabine

2013-01-01

In humans, adipose tissue is distributed in subcutaneous abdominal and subcutaneous gluteal depots that comprise a variety of functional differences. Whereas energy storage in gluteal adipose tissue has been shown to mediate a protective effect, an increase of abdominal adipose tissue is associated with metabolic disorders. However, the molecular basis of depot-specific characteristics is not completely understood yet. Using array-based analyses of transcription profiles, we identified a specific set of genes that was differentially expressed between subcutaneous abdominal and gluteal adipose tissue. To investigate the role of epigenetic regulation in depot-specific gene expression, we additionally analyzed genome-wide DNA methylation patterns in abdominal and gluteal depots. By combining both data sets, we identified a highly significant set of depot-specifically expressed genes that appear to be epigenetically regulated. Interestingly, the majority of these genes form part of the homeobox gene family. Moreover, genes involved in fatty acid metabolism were also differentially expressed. Therefore we suppose that changes in gene expression profiles might account for depot-specific differences in lipid composition. Indeed, triglycerides and fatty acids of abdominal adipose tissue were more saturated compared to triglycerides and fatty acids in gluteal adipose tissue. Taken together, our results uncover clear differences between abdominal and gluteal adipose tissue on the gene expression and DNA methylation level as well as in fatty acid composition. Therefore, a detailed molecular characterization of adipose tissue depots will be essential to develop new treatment strategies for metabolic syndrome associated complications.

Depot-specific characteristics of adipose tissue-derived stromal cells in thyroid-associated orbitopathy.

PubMed

Wong, Janice Siu Chong; Chu, Wai Kit; Li, Benjamin Fuk-Loi; Pang, Chi-Pui; Chong, Kelvin Kam-Lung

2018-04-17

Thyroid-associated orbitopathy (TAO) causes inflammatory fibroproliferation of periocular connective tissues. We compared adipose tissue-derived stem/stromal cells (ADSCs) from three adipose depots of each patient with TAO on mesenchymal, myofibrogenic, adipogenic properties and associated hyaluronan (HA) synthesis. ADSCs were generated from periocular (eyelid, orbital) and subcutaneous (abdominal) adipose tissues of three patients with TAO. Mesenchymal markers were characterised by reverse transcription-PCR and immunofluorescent staining. A 3-week adipogenic induction was evaluated by Nile red staining and quantitative PCR (qPCR) of peroxisome proliferator-activated receptor (PPARγ), adiponectin and hyaluronan synthase (HAS)-2. A 7-day myofibrogenic induction was assayed by immunofluorescent staining and qPCR of α-smooth muscle actin (α-SMA). ADSCs from all depots expressed similar levels of mesenchymal markers CD44, CD90 and CD105 (p=0.288, p=0.43 and p=0.837, respectively). After adipogenic induction, intracellular lipid increased for more than 32% and PPARγ mRNA showed more than twofold increase from all three depots. However, adiponectin and HAS-2 mRNA levels were significantly higher in the eyelid and orbital ADSCs than those from the subcutaneous ADSCs after induction (2.4×10 7 , 3.9×10 6  folds vs below detection limit; 63.3-fold, 26.1-fold, vs 33% reduction, respectively; all p=0.002). Significantly more myofibroblasts and higher mRNA level of α-SMA were obtained from the orbital and eyelid compared with the subcutaneous ADSCs during myofibrogenic induction (80.2%, 70.6% vs 29.3%; 30.2-fold, 24.2-fold vs 1.7-fold, respectively; all p=0.002). ADSCs from different adipose depots of the same donors exhibited similar mesenchymal phenotypes but differed significantly in adipogenic, myofibrogenic potentials and associated HA synthesis. These depot-specific characteristics of ADSCs may contribute to site-specific adipose tissue involvement in TAO. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Anti-PSMA/CD3 Bispecific Antibody Delivery And Anti-Tumor Activity Using A Polymeric Depot Formulation.

PubMed

Leconet, Wilhem; Liu, He; Guo, Ming; Le Lamer-Déchamps, Sophie; Molinier, Charlotte; Kim, Sae; Vrlinic, Tjasa; Oster, Murielle; Liu, Fang; Navarro, Vincent; Batra, Jaspreet S; Lopez-Noriega, Adolfo; Grizot, Sylvestre; Bander, Neil H

2018-06-11

Small therapeutic proteins represent a promising novel approach to treat cancer. Nevertheless, their clinical application is often adversely impacted by their short plasma half-life. Controlled long-term delivery of small biologicals has become a challenge because of their hydrophilic properties and in some cases their limited stability. Here, an in-situ forming depot injectable polymeric system was used to deliver BiJ591, a Bispecific T-cell Engager (BiTE) targeting both prostate-specific membrane antigen (PSMA) and the CD3 T-cell receptor in prostate cancer. BiJ591 induced T-cell activation, prostate cancer directed cell lysis and tumor growth inhibition. The use of diblock and triblock biodegradable polyethylene glycol - poly(lactic acid) (PEG-PLA) copolymers solubilized in tripropionin, a small chain triglyceride, allowed maintenance of BiJ591 stability and functionality in the formed depot and controlled its release. In mice, after a single subcutaneous injection, one of the polymeric candidates, TB1/DB4, provided the most sustained release of BiJ591 for up to 21 days. Moreover, the use of BiJ591-TB1/DB4 formulation in prostate cancer xenograft models showed significant therapeutic activity in both low and high PSMA expressing tumors whereas daily intravenous administration of BiJ591 was less efficient. Collectively, the present data provide new insights into the development of controlled delivery of small therapeutic proteins in cancer. Copyright ©2018, American Association for Cancer Research.

Army Working Capital Fund. Actions Needed to Reduce Carryover at Army Depots

DTIC Science & Technology

2008-07-01

Texarkana , Texas. Page 1 GAO-08-714 Army Working Capital Fund flow of work during the transition from one fiscal year to the next. However, past...Corpus Christi, Texas; the Anniston Army Depot, Anniston, Alabama; and the Red River Army Depot, Texarkana , Texas. We conducted this performance

Defense AT and L. Volume 37, Number 5

DTIC Science & Technology

2008-10-01

2008) GATES APPLAUDS EFFORTS AT RED RIVER ARMY DEPOT Donna Miles TEXARKANA , Texas—Defense Secretary Robert M. Gates toured Red River Army Depot...the depot workers and the Texarkana com- munity that has supported the facility for decades for their “tireless support” of the men and women in

77 FR 27790 - Federal Property Suitable as Facilities To Assist the Homeless

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... conditions; sf. varies; usage varies; needs extensive repairs Kentucky 5 Bldgs. Blue Grass Army Depot... Grass Army Depot Richmond KY 40475 Landholding Agency: Army Property Number: 21201220046 Status... E0450-0457 & E0459 Blue Grass Army Depot Richmond KY 40475 Landholding Agency: Army Property Number...

A mirccroarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice

USDA-ARS?s Scientific Manuscript database

Objective: A sexual dimorphism exists in body fat distribution; females deposit relatively more fat in subcutaneous/inguinal depots whereas males deposit more fat in the intra-abdominal/gonadal depot. Our objective was to systematically document depot- and sex-related differences in the accumulatio...

An Ant Colony Optimization algorithm for solving the fixed destination multi-depot multiple traveling salesman problem with non-random parameters

NASA Astrophysics Data System (ADS)

Ramadhani, T.; Hertono, G. F.; Handari, B. D.

2017-07-01

The Multiple Traveling Salesman Problem (MTSP) is the extension of the Traveling Salesman Problem (TSP) in which the shortest routes of m salesmen all of which start and finish in a single city (depot) will be determined. If there is more than one depot and salesmen start from and return to the same depot, then the problem is called Fixed Destination Multi-depot Multiple Traveling Salesman Problem (MMTSP). In this paper, MMTSP will be solved using the Ant Colony Optimization (ACO) algorithm. ACO is a metaheuristic optimization algorithm which is derived from the behavior of ants in finding the shortest route(s) from the anthill to a form of nourishment. In solving the MMTSP, the algorithm is observed with respect to different chosen cities as depots and non-randomly three parameters of MMTSP: m, K, L, those represents the number of salesmen, the fewest cities that must be visited by a salesman, and the most number of cities that can be visited by a salesman, respectively. The implementation is observed with four dataset from TSPLIB. The results show that the different chosen cities as depots and the three parameters of MMTSP, in which m is the most important parameter, affect the solution.

Employment-Based Reinforcement of Adherence to Depot Naltrexone in Unemployed Opioid-Dependent Adults: A Randomized Controlled Trial

PubMed Central

Everly, Jeffrey J.; DeFulio, Anthony; Koffarnus, Mikhail N.; Leoutsakos, Jeannie-Marie S.; Donlin, Wendy D.; Aklin, Will M.; Umbricht, Annie; Fingerhood, Michael; Bigelow, George E.; Silverman, Kenneth

2011-01-01

Aims Naltrexone can be used to treat opioid dependence, but patients refuse to take it. Extended-release depot formulations may improve adherence, but long-term adherence rates to depot naltrexone are not known. This study determined long-term rates of adherence to depot naltrexone and whether employment-based reinforcement can improve adherence. Design Participants who were inducted onto oral naltrexone were randomly assigned to Contingency (n=18) or Prescription (n=17) groups. Participants were offered six depot naltrexone injections and invited to work at the therapeutic workplace weekdays for 26 weeks where they earned stipends for participating in job skills training. Contingency participants were required to accept naltrexone injections to maintain workplace access and to maintain maximum pay. Prescription participants could work independent of whether they accepted injections. Setting The therapeutic workplace, a model employment-based intervention for drug addiction and unemployment. Participants Opioid-dependent unemployed adults. Measurements Depot naltrexone injections accepted and opiate-negative urine samples. Findings Contingency participants accepted significantly more naltrexone injections than Prescription participants (81% versus 42%), and were more likely to accept all injections (66% versus 35%). At monthly assessments (with missing urine samples imputed as positive), the groups provided similar percentages of samples negative for opiates (74% versus 62%) and for cocaine (56% versus 54%). Opiate positive samples were more likely when samples were also positive for cocaine. Conclusions Employment-based reinforcement can maintain adherence to depot naltrexone. Future research should determine whether persistent cocaine use compromises naltrexone's effect on opiate use. Workplaces may be useful for promoting sustained adherence to depot naltrexone. PMID:21320227

Extending the Aircraft Availability Model to a Constrained Depot Environment Using Activity-Based Costing and the Theory of Constraints

DTIC Science & Technology

2004-06-01

Overselling Activity-Based Concepts,” Management Accounting , September 1992:26-35. Kaplan, Robert S . and Robin Cooper. Cost & Effect. Using... Accounting .............................................14 Increasing Need for Cost Information...15 Implications for Costs Accounting Systems ....................................................17 Section 2 – Costs and Resources

Eighth year projects and activities of the Environmental Remote Sensing Applications Laboratory (ERSAL). [Oregon

NASA Technical Reports Server (NTRS)

Lewis, A. J.; Isaacson, D. L.; Schrumpf, B. J. (Principal Investigator)

1980-01-01

Projects completed for the NASA Office of University Affairs include the application of remote sensing data in support of rehabilitation of wild fire damaged areas and the use of LANDSAT 3 return beam vidicon in forestry mapping applications. Continuing projects for that office include monitoring western Oregon timber clearcut; detecting and monitoring wheat disease; land use monitoring for tax assessment in Umatilla, Lake, and Morrow Counties; and the use of Oregon Air National Guard thermal infrared scanning data. Projects funded through other agencies include the remote sensing inventory of elk in the Blue Mountains; the estimation of burned agricultural acreage in the Willamette Valley; a resource inventory of Deschutes County; and hosting a LANDSAT digital workshop.

33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Depot, Manchester, Washington; naval restricted area. 334.1244 Section 334.1244 Navigation and Navigable... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a... the military or naval authority shall enter the area without the permission of the enforcing agency or...

33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Depot, Manchester, Washington; naval restricted area. 334.1244 Section 334.1244 Navigation and Navigable... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a... the military or naval authority shall enter the area without the permission of the enforcing agency or...

A mircroarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice

USDA-ARS?s Scientific Manuscript database

A sexual dimorphism exists in body fat distribution; females deposit relatively more fat in subcutaneous/inguinal depots whereas males deposit more fat in the intra-abdominal/gonadal depot. Our objective was to systematically document depot- and sex-related differences in the accumulation of adipose...

Architecture Study for a Fuel Depot Supplied from Lunar Assets

NASA Technical Reports Server (NTRS)

Perrin, Thomas M.; Casler, James G.

2016-01-01

This architecture study sought to determine the optimum architecture for a fuel depot supplied from lunar assets. Four factors - the location of propellant processing (on the Moon or on the depot), the depot location (on the Moon, L1, GEO, or LEO), the propellant transfer location (L1, GEO, or LEO), and the propellant transfer method (bulk fuel or canister exchange) were combined to identify 18 candidate architectures. Two design reference missions (DRMs) - a commercial satellite servicing mission and a Government cargo mission to Mars - created demand for propellants, while a propellant delivery DRM examined supply issues. The study concluded Earth-Moon L1 is the best location for an orbiting depot. For all architectures, propellant boiloff was less than anticipated, and was far overshadowed by delta-v requirements and resulting fuel consumption. Bulk transfer is the most flexible for both the supplier and customer. However, since canister exchange bypasses the transfer of bulk cryogens and necessary chilldown losses, canister exchange shows promise and merits further investigation. Overall, this work indicates propellant consumption and loss is an essential factor in assessing fuel depot architectures.

First report of tobacco rattle virus causing corky ring spot in potatoes grown in Minnesota and Wisconsin

USDA-ARS?s Scientific Manuscript database

In July 2007, potato tubers cv. Russet Burbank (RB) with necrotic arcs and spots were detected in three fields in Buffalo County, Wisconsin and one field in Benson County, Minnesota. Umatilla Russet (UR) potatoes harvested from the west half of a field in Swift County, MN had similar, but visually ...

Timber resource statistics for all forest land, except national forests, in eastern Oregon.

Treesearch

Donald R. Gedney; Patricia M. Bassett; Mary A. Mei

1989-01-01

This report summarizes a 1987 timber resource inventory of all forest land, except National Forests, in the 17 counties (Baker, Crook, Deschutes, Gilliam, Grant, Harney, Jefferson, Klamath, Lake, Malheur, Morrow, Sherman, Umatilla, Union, Wallowa, Wasco, and Wheeler Counties) in eastern Oregon. Detailed tables of forest area, timber volume, growth, mortality, and...

Rangeland exclosures of northeastern Oregon: stories they tell (1936–2004).

Treesearch

Charles Grier Johnson

2007-01-01

Rangeland exclosures installed primarily in the 1960s, but with some from the 1940s, were resampled for changes in plant community structure and composition periodically from 1977 to 2004 on the Malheur, Umatilla, and Wallowa-Whitman National Forests in northeastern Oregon. They allow one to compare vegetation with all-ungulate exclusion (known historically as game...

Baseline climatic and hydrologic relationships for the high ridge evaluation area.

Treesearch

W. B. Fowler; J. D. Helvey; C. Johnson

1980-01-01

This report summarizes the climatic and hydrologic measurements taken in the High Ridge evaluation area, a four-watershed complex within the Umatilla barometer watershed of eastern Oregon. The information—measurements of water yield; air, soil, and water temperatures; snow depth and density; and wind—is presented to identify the pretreatment condition...

75 FR 68510 - Fresh Prunes Grown in Designated Counties in Washington and in Umatilla County, OR; Termination...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... marketing agreements and orders may be viewed at: http://www.ams.usda.gov/MarketingOrdersSmallBusinessGuide... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 924 [Doc. No. AMS-FV-10-0053...; Termination of Marketing Order 924 AGENCY: Agricultural Marketing Service, USDA. ACTION: Proposed rule...

Intramuscular preparations of antipsychotics: uses and relevance in clinical practice.

PubMed

Altamura, A Cario; Sassella, Francesca; Santini, Annalisa; Montresor, Clauno; Fumagalli, Sara; Mundo, Emanuela

2003-01-01

Intramuscular formulations of antipsychotics can be sub-divided into two groups on the basis of their pharmacokinetic features: short-acting preparations and long-acting or depot preparations. Short-acting intramuscular formulations are used to manage acute psychotic episodes. On the other hand, long-acting compounds, also called "depot", are administered as antipsychotic maintenance treatment to ensure compliance and to eliminate bioavailability problems related to absorption and first pass metabolism. Adverse effects of antipsychotics have been studied with particular respect to oral versus short- and long-acting intramuscular formulations of the different compounds. For short-term intramuscular preparations the main risk with classical compounds are hypotension and extrapyramidal side effects (EPS). Data on the incidence of EPS with depot formulations are controversial: some studies point out that the incidence of EPS is significantly higher in patients receiving depot preparations, whereas others show no difference between oral and depot antipsychotics. Studies on the strategies for switching patients from oral to depot treatment suggest that this procedure is reasonably well tolerated, so that in clinical practice depot antipsychotic therapy is usually begun while the oral treatment is still being administered, with gradual tapering of the oral dose. Efficacy, pharmacodynamics and clinical pharmacokinetics of haloperidol decanoate, fluphenazine enanthate and decanoate, clopenthixol decanoate, zuclopenthixol decanoate and acutard, flupenthixol decanoate, perphenazine enanthate, pipothiazine palmitate and undecylenate, and fluspirilene are reviewed. In addition, the intramuscular preparations of atypical antipsychotics and clinical uses are reviewed. Olanzapine and ziprasidone are available only as short-acting preparations, while risperidone is to date the only novel antipsychotic available as depot formulation. To date, acutely ill, agitated psychotic patients have been treated with high parenteral doses of typical antipsychotics, which often cause serious EPS, especially dystonic reactions. Intramuscular formulations of novel antipsychotics (olanzapine and ziprasidone), which appear to have a better tolerability profile than typical compounds, showed an equivalent efficacy to parenteral typical agents in the acute treatment of psychoses. However, parenteral or depot formulations of atypical antipsychotics are not yet widely available.

An Analysis of the Cost Accounting System for the Depot Maintenance Service, Air Force Industrial Fund.

DTIC Science & Technology

1987-09-01

AN A NALYSIS OF THE COST ACCOUNTING SYSTEM FOR THE DEPOT 1/1 MRINTENANCE SERVI..(U) MIR FORCE INST OF TECH IIGHT-PTTERSON RFB OH SCHOOL OF SYST.. 0 L...I "VV h S~ ~~i FiLE COV, THSI CIO ~OF AN ANALYSIS OF THE COST ACCOUNTING SYSTEM FOR THE DEPOT MAINTENANCE SERVICE, AIR FORCE INDUSTRIAL FUND...Patterson Air Force Base, Ohio ~ p~UOW~~ ’ I ~ 1 12 02 0 AFIT/GLM/LSY/87S-83 AN ANALYSIS OF THE COST ACCOUNTING SYSTEM FOR THE DEPOT MAINTENANCE SERVICE, AIR

Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI.

PubMed

Hu, Houchun H; Yin, Larry; Aggabao, Patricia C; Perkins, Thomas G; Chia, Jonathan M; Gilsanz, Vicente

2013-10-01

To compare fat-signal fractions (FFs) and T2* values between brown (BAT) and white (WAT) adipose tissue located within the supraclavicular fossa and subcutaneous depots, respectively. Twelve infants and 39 children were studied. Children were divided into lean and overweight/obese subgroups. Chemical-shift-encoded water-fat magnetic resonance imaging (MRI) was used to quantify FFs and T2* metrics in the supraclavicular and adjacent subcutaneous adipose tissue depots. Linear regression and t-tests were performed. Infants had lower supraclavicular FFs than children (P < 0.01) but T2* values were similar (P = 0.5). Lean children exhibited lower supraclavicular FFs and T2* values than overweight children (P < 0.01). In each individual infant and child, supraclavicular FFs were consistently lower than adjacent subcutaneous FFs. Supraclavicular T2* values were consistently lower than subcutaneous T2* values in children, but not in infants. FFs in both depots were positively correlated with age and weight in infants (P < 0.01). In children, they were correlated with weight and body mass index (BMI) (P < 0.01), but not age. Correlations between T2* and anthropometric variables existed in children (P < 0.01), but were absent in infants. Cross-sectional comparisons suggest variations in FF and T2* values in the supraclavicular and subcutaneous depots of infants and children, which are potentially indicative of physiological differences in adipose tissue fat content, amount, and metabolic activity. Copyright © 2013 Wiley Periodicals, Inc.

Depot-medication compliance for patients with psychotic disorders: the importance of illness insight and treatment motivation.

PubMed

Noordraven, Ernst L; Wierdsma, André I; Blanken, Peter; Bloemendaal, Anthony Ft; Mulder, Cornelis L

2016-01-01

Noncompliance is a major problem for patients with a psychotic disorder. Two important risk factors for noncompliance that have a severe negative impact on treatment outcomes are impaired illness insight and lack of motivation. Our cross-sectional study explored how they are related to each other and their compliance with depot medication. Interviews were conducted in 169 outpatients with a psychotic disorder taking depot medication. Four patient groups were defined based on low or high illness insight and on low or high motivation. The associations between depot-medication compliance, motivation, and insight were illustrated using generalized linear models. Generalized linear model showed a significant interaction effect between motivation and insight. Patients with poor insight and high motivation for treatment were more compliant (94%) (95% confidence interval [CI]: 1.821, 3.489) with their depot medication than patients with poor insight and low motivation (61%) (95% CI: 0.288, 0.615). Patients with both insight and high motivation for treatment were less compliant (73%) (95% CI: 0.719, 1.315) than those with poor insight and high motivation. Motivation for treatment was more strongly associated with depot-medication compliance than with illness insight. Being motivated to take medication, whether to get better or for other reasons, may be a more important factor than having illness insight in terms of improving depot-medication compliance. Possible implications for clinical practice are discussed.

Depot-Specific Response of Adipose Tissue to Diet-Induced Inflammation: The Retinoid-Related Orphan Receptor α (RORα) Involved?

PubMed

Kadiri, Sarah; Auclair, Martine; Capeau, Jacqueline; Antoine, Bénédicte

2017-11-01

Epididymal adipose tissue (EAT), a visceral fat depot, is more closely associated with metabolic dysfunction than inguinal adipose tissue (IAT), a subcutaneous depot. This study evaluated whether the nuclear receptor RORα, which controls inflammatory processes, could be implicated. EAT and IAT were compared in a RORα loss-of-function mouse (sg/sg) and in wild-type (WT) littermates, fed a standard diet (SD) or a Western diet (WD), to evaluate the impact of RORα expression on inflammatory status and on insulin sensitivity (IS) of each fat depot according to the diet. Sg/sg mice fed the SD exhibited a decreased inflammatory status and a higher IS in their fat depots than WT mice. WD-induced obesity had distinct effects on the two fat depots. In WT mice, EAT exhibited increased inflammation and insulin resistance while IAT showed reduced inflammation and improved IS, together with a depot-specific increase of RORα, and its target gene IκBα, in the stroma vascular fraction (SVF). Conversely, in sg/sg mice, WD increased inflammation and lowered IS of IAT but not of EAT. These findings suggest an anti-inflammatory role for RORα in response to WD, which occurs at the level of SVF of IAT, thus possibly contributing to the "healthy" expansion of IAT. © 2017 The Obesity Society.

A Guide to Running a Recycling Project. [Includes Recycling Handbook].

ERIC Educational Resources Information Center

Oregon Recycling Information and Organizing Network, Portland.

This guide, designed for both students and adults, is intended for individuals who feel they might be interested in establishing a recycling depot. The guide includes such pertinent information as deciding how to set up a depot, markets and transportation, preparation of materials, where to place the depot and when to operate it, publicity and…

33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Puget Sound, Manchester Fuel... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a) The area. The waters of Puget Sound surrounding the Manchester Fuel Depot Point A, a point along the...

33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Puget Sound, Manchester Fuel... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a) The area. The waters of Puget Sound surrounding the Manchester Fuel Depot Point A, a point along the...

33 CFR 334.1244 - Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Puget Sound, Manchester Fuel... REGULATIONS § 334.1244 Puget Sound, Manchester Fuel Depot, Manchester, Washington; naval restricted area. (a) The area. The waters of Puget Sound surrounding the Manchester Fuel Depot Point A, a point along the...

Employment-based reinforcement of adherence to depot naltrexone in unemployed opioid-dependent adults: a randomized controlled trial.

PubMed

Everly, Jeffrey J; DeFulio, Anthony; Koffarnus, Mikhail N; Leoutsakos, Jeannie-Marie S; Donlin, Wendy D; Aklin, Will M; Umbricht, Annie; Fingerhood, Michael; Bigelow, George E; Silverman, Kenneth

2011-07-01

Naltrexone can be used to treat opioid dependence, but patients refuse to take it. Extended-release depot formulations may improve adherence, but long-term adherence rates to depot naltrexone are not known. This study determined long-term rates of adherence to depot naltrexone and whether employment-based reinforcement can improve adherence. Participants who were inducted onto oral naltrexone were assigned randomly to contingency (n = 18) or prescription (n = 17) groups. Participants were offered six depot naltrexone injections and invited to work at the therapeutic workplace on week days for 26 weeks, where they earned stipends for participating in job skills training. Contingency participants were required to accept naltrexone injections to maintain workplace access and to maintain maximum pay. Prescription participants could work independently of whether they accepted injections. The therapeutic workplace, a model employment-based intervention for drug addiction and unemployment. Opioid-dependent unemployed adults. Depot naltrexone injections accepted and opiate-negative urine samples. Contingency participants accepted significantly more naltrexone injections than prescription participants (81% versus 42%), and were more likely to accept all injections (66% versus 35%). At monthly assessments (with missing urine samples imputed as positive), the groups provided similar percentages of samples negative for opiates (74% versus 62%) and for cocaine (56% versus 54%). Opiate-positive samples were more likely when samples were also positive for cocaine. Employment-based reinforcement can maintain adherence to depot naltrexone. Future research should determine whether persistent cocaine use compromises naltrexone's effect on opiate use. Workplaces may be useful for promoting sustained adherence to depot naltrexone. © 2011 The Authors, Addiction © 2011 Society for the Study of Addiction.

Propellant Depots: The Future of Space Exploration

NASA Astrophysics Data System (ADS)

Crenwelge, Drew

NASA is currently exploring several options for mankind's return to the lunar surface and beyond. The selected option must stimulate both commercial and international involvement, support future missions to the Moon and other destinations, and above all, fit within the current budget profile. Contrary to the current Constellation approach, this paper describes the option of using an in-space propellant depot architecture that can refuel or top-off visiting vehicles at EML1, and how it fits within NASA's new space exploration criteria. In addition to receiving and transferring fuel, the propellant depot will also provide cryogenic propellant storage and management that utilizes flight proven technologies in conjunction with technologies currently under development. The propellant depot system, propellant management and acquisition devices, thermodynamic analysis, and key enabling technologies are also discussed. Depot design concepts along with an overview of a future lunar mission sequence are also presented.

Synergistic anti-tumor activity through combinational intratumoral injection of an in-situ injectable drug depot.

PubMed

Kim, Da Yeon; Kwon, Doo Yeon; Kwon, Jin Seon; Park, Ji Hoon; Park, Seung Hun; Oh, Hyun Ju; Kim, Jae Ho; Min, Byoung Hyun; Park, Kinam; Kim, Moon Suk

2016-04-01

Here, we describe combinational chemotherapy via intratumoral injection of doxorubicin (Dox) and 5-fluorouracil (Fu) to enhance the efficacy and reduce the toxicity of systemically administered Fu and Dox in cancer patients. As the key concept in this work, mixture formulations of Dox-loaded microcapsules (Dox-M) and Fu-loaded Pluronic(®) hydrogels (Fu-HP) or Fu-loaded diblock copolymer hydrogels (Fu-HC) have been employed as drug depots. The in vitro and in vivo drug depot was designed as a formulation of Dox-M dispersed inside an outer shell of Fu-HP or Fu-HC after injection. The Dox-M/Fu-HP and Dox-M/Fu-HC formulations are free flowing at room temperature, indicating injectability, and formed a structural gelatinous depot in vitro and in vivo at body temperature. The Fu-HP, Fu-HC, Dox-M/Fu-HP, Dox-M/Fu-HC, and Dox-M formulations were easily injected into tumor centers in mice using a needle. Dox-M/Fu-HC produced more significant inhibitory effects against tumor growth than that by Dox-M/Fu-HP, while Fu-HP, Fu-HC and Dox-M had the weakest inhibitory effects of the tested treatments. The in vivo study of Dox and Fu biodistribution showed that high Dox and Fu concentrations were maintained in the target tumor only, while distribution to normal tissues was not observed, indicating that Dox and Fu concentrations below their toxic plasma concentrations should not cause significant systemic toxicity. The Dox-M/Fu-HP and Dox-M/Fu-HC drug depots described in this work showed excellent performance as chemotherapeutic delivery systems. The results reported here indicate that intratumoral injection using combination chemotherapy with Dox-M/Fu-HP or Dox-M/Fu-HC could be of translational research by enhancing the synergistic inhibitory effects of Dox and Fu on tumor growth, while reducing their systemic toxicity in cancer patients. Copyright © 2016 Elsevier Ltd. All rights reserved.

Energy Engineering Analysis Program, limited energy study of steam distribution systems, Hawthorne Army Ammunition Depot, Hawthorne, Nevada. Programming documents

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-09-01

The project is a significant part of Hawthorne Army Ammunition Depot`s effort to achieve a 20-percent reduction in energy consumption by FY2000 versus FY1985 baseline levels. The project will also assure that heating services are provided to Industrial Area facilities on a continuing basis, supporting mission requirements.

33 CFR 334.510 - U.S. Navy Fuel Depot Pier, St. Johns River, Jacksonville, Fla.; restricted area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false U.S. Navy Fuel Depot Pier, St. Johns River, Jacksonville, Fla.; restricted area. 334.510 Section 334.510 Navigation and Navigable... REGULATIONS § 334.510 U.S. Navy Fuel Depot Pier, St. Johns River, Jacksonville, Fla.; restricted area. (a) The...

Homing pigeons ( Columba livia f. domestica) can use magnetic cues for locating food

NASA Astrophysics Data System (ADS)

Thalau, Peter; Holtkamp-Rötzler, Elke; Fleissner, Gerta; Wiltschko, Wolfgang

2007-10-01

An experimental group of homing pigeons ( Columba livia f. domestica) learned to associate food with a magnetic anomaly produced by bar magnets that were fixed to the bowl in which they received their daily food ration in their home loft; the control group lacked this experience. Both groups were trained to search for two hidden food depots in a rectangular sand-filled arena without obvious visual cues; for the experimental birds, these depots were also marked with three 1.15 × 106 μT bar magnets. During the tests, there were two food depots, one marked with the magnets, the other unmarked; their position within the arena was changed from test to test. The experimental birds searched within 10 cm of the magnetically marked depot in 49% of the test sessions, whereas the control birds searched there in only 11% of the sessions. Both groups searched near the control depot in 11 and 13% of the sessions, respectively. The significant preference of the magnetically marked food depot by the experimental birds shows that homing pigeons cannot only detect a magnetic anomaly but can also use it as a cue for locating hidden food in an open arena.

A Practical, Affordable Cryogenic Propellant Depot Based on ULA's Flight Experience

NASA Technical Reports Server (NTRS)

Kutter, Bernard F.; Zegler, Frank; O'Neil, Gary; Pitchford, Brian

2008-01-01

Mankind is embarking on the next step in the journey of human exploration. We are returning to the moon and eventually moving to Mars and beyond. The current Exploration architecture seeks a balance between the need for a robust infrastructure on the lunar surface, and the performance limitations of Ares I and V. The ability to refuel or top-off propellant tanks from orbital propellant depots offers NASA the opportunity to cost effectively and reliably satisfy these opposing requirements. The ability to cache large orbital quantities of propellant is also an enabling capability for missions to Mars and beyond. This paper describes an option for a propellant depot that enables orbital refueling supporting Exploration, national security, science and other space endeavors. This proposed concept is launched using a single EELV medium class rocket and thus does not require any orbital assembly. The propellant depot provides cryogenic propellant storage that utilizes flight proven technologies augmented with technologies currently under development. The propellant depot system, propellant management, flight experience, and key technologies are also discussed. Options for refueling the propellant depot along with an overview of Exploration architecture impacts are also presented.

Space Resource Requirements for Future In-Space Propellant Production Depots

NASA Technical Reports Server (NTRS)

Smitherman, David; Fikes, John; Roy, Stephanie; Henley, Mark W.; Potter, Seth D.; Howell, Joe T. (Technical Monitor)

2001-01-01

In 2000 and 2001 studies were conducted at the NASA Marshall Space Flight Center on the technical requirements and commercial potential for propellant production depots in low Earth orbit (LEO) to support future commercial, NASA, and other Agency missions. Results indicate that propellant production depots appear to be technically feasible given continued technology development, and there is a substantial growing market that depots could support. Systems studies showed that the most expensive part of transferring payloads to geosynchronous orbit (GEO) is the fuel. A cryogenic propellant production and storage depot stationed in LEO could lower the cost of missions to GEO and beyond. Propellant production separates water into hydrogen and oxygen through electrolysis. This process utilizes large amounts of power, therefore a depot derived from advanced space solar power technology was defined. Results indicate that in the coming decades there could be a significant demand for water-based propellants from Earth, moon, or asteroid resources if in-space transfer vehicles (upper stages) transitioned to reusable systems using water based propellants. This type of strategic planning move could create a substantial commercial market for space resources development, and ultimately lead toward significant commercial infrastructure development within the Earth-Moon system.

Broiler chicken adipose tissue dynamics during the first two weeks post-hatch.

PubMed

Bai, Shiping; Wang, Guoqing; Zhang, Wei; Zhang, Shuai; Rice, Brittany Breon; Cline, Mark Andrew; Gilbert, Elizabeth Ruth

2015-11-01

Selection of broiler chickens for growth has led to increased adipose tissue accretion. To investigate the post-hatch development of adipose tissue, the abdominal, clavicular, and subcutaneous adipose tissue depots were collected from broiler chicks at 4 and 14 days post-hatch. As a percent of body weight, abdominal fat increased (P<0.001) with age. At day 4, clavicular and subcutaneous fat depots were heavier (P<0.003) than abdominal fat whereas at day 14, abdominal and clavicular weighed more (P<0.003) than subcutaneous fat. Adipocyte area and diameter were greater in clavicular and subcutaneous than abdominal fat at 4 and 14 days post-hatch (P<0.001). Glycerol-3-phosphate dehydrogenase (G3PDH) activity increased (P<0.001) in all depots from day 4 to 14, and at both ages was greatest in subcutaneous, intermediate in clavicular, and lowest in abdominal fat (P<0.05). In clavicular fat, peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer binding protein (CEBP)α, CEBPβ, fatty acid synthase (FASN), fatty acid binding protein 4 (FABP4), lipoprotein lipase (LPL), neuropeptide Y (NPY), and NPY receptor 5 (NPYR5) mRNA increased and NPYR2 mRNA decreased from day 4 to 14 (P<0.001). Thus, there are site-specific differences in broiler chick adipose development, with larger adipocytes and greater G3PDH activity in subcutaneous fat at day 4, more rapid growth of abdominal fat, and clavicular fat intermediate for most traits. Adipose tissue expansion was accompanied by changes in gene expression of adipose-associated factors. Copyright © 2015 Elsevier Inc. All rights reserved.

Geohydrology and ground-water quality at the Pueblo Depot activity landfill near Pueblo, Colorado

USGS Publications Warehouse

Watts, Kenneth R.; Ortiz, Roderick F.

1990-01-01

Groundwater samples were collected from the shallow unconfined aquifer at the Pueblo Depot Activity (Colorado) landfill and downstream from the landfill. The Pueblo Depot Activity is a U.S. Department of the Army facility in southeastern Colorado about 15 miles east of Pueblo, Colorado. The land-fill is underlain by upland alluvial terrace deposits that overlie a thick and almost impermeable shale. Saturated thickness of the aquifer generally is from 5 to 10 feet. Groundwater flow at the landfill is to the south-southeast toward the Arkansas River valley. Though not hydraulically connected to the upland terrace deposits, the alluvium underlying the Arkansas River valley may be recharged by groundwater that is discharged from seeps at the contact of the upland terrace deposits and the Pierre Shale. The water is classified as a mixed-cation mixed-anion type water that has concentrations of dissolved solids of 710 to 1,810 mg/L. Dissolved-solids concentrations increase downgradient. Chemical analysis, done to determine possible contamination of the groundwater, indicated that concentrations of trichloroethylene ranged from 5.2 to 2,900 microg/L and of trans-1,2-dichloroethylene ranged from 5 to 720 microg/L. The areal distribution of these volatile organic compounds indicate that there possibly are two sources of contamination of groundwater at the landfill, one upgradient from the landfill and the other within the landfill. Analysis of water samples from wells and seeps offsite and downgradient from the landfill did not indicate either contaminant in groundwater from the alluvial aquifer underlying the Arkansas River valley. (USGS)

77 FR 33204 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement for the Long-Term...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... activities, and generated as a byproduct of the gold mining process. In addition, DOE's National Nuclear... Junction, Colorado; DOE Hanford site near Richland, Washington; Hawthorne Army Depot near Hawthorne, Nevada...

Depot-medication compliance for patients with psychotic disorders: the importance of illness insight and treatment motivation

PubMed Central

Noordraven, Ernst L; Wierdsma, André I; Blanken, Peter; Bloemendaal, Anthony FT; Mulder, Cornelis L

2016-01-01

Background Noncompliance is a major problem for patients with a psychotic disorder. Two important risk factors for noncompliance that have a severe negative impact on treatment outcomes are impaired illness insight and lack of motivation. Our cross-sectional study explored how they are related to each other and their compliance with depot medication. Methods Interviews were conducted in 169 outpatients with a psychotic disorder taking depot medication. Four patient groups were defined based on low or high illness insight and on low or high motivation. The associations between depot-medication compliance, motivation, and insight were illustrated using generalized linear models. Results Generalized linear model showed a significant interaction effect between motivation and insight. Patients with poor insight and high motivation for treatment were more compliant (94%) (95% confidence interval [CI]: 1.821, 3.489) with their depot medication than patients with poor insight and low motivation (61%) (95% CI: 0.288, 0.615). Patients with both insight and high motivation for treatment were less compliant (73%) (95% CI: 0.719, 1.315) than those with poor insight and high motivation. Conclusion Motivation for treatment was more strongly associated with depot-medication compliance than with illness insight. Being motivated to take medication, whether to get better or for other reasons, may be a more important factor than having illness insight in terms of improving depot-medication compliance. Possible implications for clinical practice are discussed. PMID:26893565

Bunchgrass plant communities of the Blue and Ochoco Mountains: a guide for managers.

Treesearch

Charles Grier Johnson; David K. Swanson

2005-01-01

A classification of bunchgrass vegetation is presented for the Malheur, Ochoco, Umatilla, and part of the Wallowa-Whitman National Forests. It includes grassland vegetation as well as shrubland and forest land where the herbaceous layer is dominated by bunchgrasses. It is based on potential vegetation, with the plant association as the basic unit. Diagnostic keys and...

Using WEPP technology to predict erosion and runoff following wildfire

Treesearch

William J. Elliot; Ina Sue Miller; Brandon D. Glaza

2006-01-01

Erosion following wildfire can be as much as 1000 times the erosion from an undisturbed forest. In August, 2005, the largest fire in the lower 48 states occurred in the Umatilla National Forest in Southeast Washington. Researchers from the Rocky Mountain Research Station assisted the forest in estimating soil erosion using three different applications of the WEPP model...

Tailed frogs: distribution, ecology, and association with timber harvest in northeastern Oregon.

Treesearch

Evelyn L. Bull; Bernie E. Carter

1996-01-01

Tailed frogs (Ascaphus truei) were found in 42 of 80 streams surveyed in Union, Umatilla, Wallowa, and Baker Counties in 1992. At least three size classes of larvae were identified in seven of the streams, thereby suggesting that larvae transform after spending 3 or more years in the streams. The amount of cobble and fines in the streambed best...

'Umatilla' snow buckwheat for rangeland restoration in the interior Pacific Northwest

Treesearch

A. R. Tiedemann; S. M. Lambert; J. R. Carlson; C. J. Perry; N. L. Shaw; B. L. Welch; C. H. Driver

1997-01-01

Native plants are generally considered the best option for plant materials to restore productivity and diversity to degraded rangelands (McArthur 1988). It is difficult to find native plants capable of becoming established from seed in dense stands of introduced annual species such as cheatgrass. It has been easier to import species such as crested wheatgrass to...

The Lick Creek Demonstration - Forest Renewal Through Partial Harvest and Fire

Treesearch

Benjamin Zamora; Melinda Martin

2006-01-01

The Lick Creek Demonstration Site on the Pomeroy Ranger District, Umatilla National Forest, is a Joint Fire Science Program sponsored project to create a demonstration of the effects of fuels management on forest health. The project was initiated in 2001 and involved the integration of two levels of partial harvest with prescribed fire, a burn only treatment and an...

Defense Depot Tracy Total Quality Management Plan

DTIC Science & Technology

1989-07-01

PAGES TQM (Total Quality Management ), Depot Operations, Continuous Process Improvement 16. PRICE CODE 17. SECURITY CLASSIFICATION 18. SECURITY...make up our pcrceptions of Total Quality Management . Our goal is to improve those proven management processes that have brought us success while being...MANIAGEMENT F. QUALITY AUDITS OF PRODUCTS AND OPERATIONS ASSETS MANAGEMENT 00 i .......... / ~899 29 03 1 EFENSE DEPOT TACY TOTAL QUALITY MANAGEMENT PLAN

Total Quality Management Implementation Plan: Defense Depot, Ogden

DTIC Science & Technology

1989-07-01

NUMBERS Total Quality Management Implementation Plan Defense Depot Ogden 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING...PAGES TQM (Total Quality Management ), Continuous Process Improvement, Depot Operations, Process Action Teams 16. PRICE CODE 17. SECURITY...034 A Message From The Commander On Total Quality Management i fully support the DLA aoproacii to Total Quality Management . As stated by General

ACTH Antibodies in Patients Receiving Depot Porcine ACTH to Hasten Recovery from Pituitary-Adrenal Suppression*

PubMed Central

Fleischer, Norman; Abe, Kaoru; Liddle, Grant W.; Orth, David N.; Nicholson, Wendell E.

1967-01-01

Six patients who had experienced prolonged steroid-induced pituitary-adrenal suppression were treated with 100 U of depot procine ACTH every 2 to 4 days for several months. Such treatment did not hasten the recovery of normal pituitary-adrenal function compared with the rate of recovery of a group of similarly suppressed patients who received no depot ACTH. Eight of nine patients who received prolonged courses of depot porcine ACTH developed antibodies to ACTH that cross-reacted with endogenous ACTH, binding it in the circulation in inactive form and retarding its removal from the circulation. The presence of such antibodies did not in itself grossly alter pituitary-adrenal interrelationships. Images PMID:4289551

77 FR 68737 - Procurement List, Proposed Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

...: Janitorial/Custodial, Defense Logistics Agency: Point Pleasant Depot, Defense National Stockpile Zone, 2601 Madison Avenue, Point Pleasant, WV. NPA: Prestera Center for Mental Health Services, Inc., Huntington, WV. Contracting Activity: Defense Logistics Agency Support Services-- DSS, Fort Belvoir, VA. Service Type/Location...

Treatment of central precocious puberty by subcutaneous injections of leuprorelin 3-month depot (11.25 mg).

PubMed

Carel, Jean-Claude; Lahlou, Najiba; Jaramillo, Orlando; Montauban, Vincent; Teinturier, Cécile; Colle, Michel; Lucas, Christel; Chaussain, Jean Louis

2002-09-01

Depot GnRH agonists are widely used for the treatment of precocious puberty. Leuprorelin 3-month depot is currently used in adults but has not been evaluated in children. We evaluated the efficacy of this new formulation (11.25 mg every 3 months), for the suppression of gonadotropic activation and pubertal signs in children with central precocious puberty. We included 44 children (40 girls) with early-onset pubertal development in a 6-month open trial. The inclusion criteria were clinical pubertal development before the age of 8 (girls) or 10 (boys), advanced bone age, enlarged uterus (>36 mm), testosterone more than 1.7 nmol/liter (boys), and pubertal response of LH to GnRH (peak >5 IU/liter). The principal criterion for efficacy assessment, GnRH-stimulated LH peak less than 3 IU/liter, was met in 81 of 85 (95%) of the tests performed at months 3 and 6. The remaining four values were slightly above the threshold. The levels of sex steroids were also significantly reduced and clinical pubertal development was arrested. Plasma leuprorelin levels, measured every 30 d, were essentially stable after d 60. Local intolerance was noted after 10 of 86 injections (12%), and was mild in four cases, moderate in five cases, and severe in one. Among these 10 events, 4 consisted in local pain at injection's site. In conclusion, leuprorelin 3-month depot efficiently inhibits the gonadotropic axis in 95% of children with central precocious puberty studied for a 6-month period. This regimen allows the reduction of the number of yearly injections from 12 to 4.

Examining a Paradigm Shift in Organic Depot-Level Software Maintenance for Army Communications and Electronics Equipment

DTIC Science & Technology

2015-05-30

scalable application of cutting edge technologies. 20 4. Responding to changing resources—With likely significant resource reductions the depot...deal with underutilized organic capability while continuing to increase outsourcing of depot workload. In addition the study states that a...the unique organic skills that TYAD could 40 bring to the software sustainment mission could be valuable based on the specific type of software

Recapitalization and Acquisition of Light Tactical Wheeled Vehicles (REDACTED)

DTIC Science & Technology

2010-01-29

representative from Red River Army Depot in Texarkana , Texas,18 stated that recapitalizing current HMMWVs to the XM1166 model was an excellent proposition...Red River Army Depot in Texarkana , Texas, stated that recapitalizing current HMMWVs to the XM1166 model was an excellent proposition. The Deputy...Army Depot in Texarkana , Texas, stated that recapitalizing current HMMWVs to the XM1166 model was an excellent proposition because the U.S

DOE Office of Scientific and Technical Information (OSTI.GOV)

Belangia, David Warren

The Home Depot Data Breach is the second largest data breach on record. It has or will affect up to 56 million debit or credit cards. A trusted vendor account, coupled with the use of a previously unknown variant of malware that allowed the establishment of a foothold, was the entry point into the Home Depot network. Once inside the perimeter, privilege escalation provided an avenue to obtain the desired information. Home Depot did, however, learn some lessons from Target. Home Depot certainly communicated better than Target, procured insurance, and instituted as secure an environment as possible. There are specificmore » measures an institution should undertake to prepare for a data breach, and everyone can learn from this breach. Publicly available information about the Home Depot Data Breach provides insight into the attack, an old malware variant with a new twist.While the malware was modified as to be unrecognizable with tools, it probably should have been detected. There are also concerns with Home Depot’s insurance and the insurance provider’s apparent lack of fully reimbursing Home Depot for their losses. The effect on shareholders and Home Depot’s stock price was short lived. This story is still evolving but provides interesting lessons learned concerning how an organization should prepare for it inevitable breach.« less

A Cryogenic Propellant Production Depot for Low Earth Orbit

NASA Technical Reports Server (NTRS)

Potter, Seth D.; Henley, Mark; Guitierrez, Sonia; Fikes, John; Carrington, Connie; Smitherman, David; Gerry, Mark; Sutherlin, Steve; Beason, Phil; Howell, Joe (Technical Monitor)

2001-01-01

The cost of access to space beyond low Earth orbit can be lowered if vehicles can refuel in orbit. The power requirements for a propellant depot that electrolyzes water and stores cryogenic oxygen and hydrogen can be met using technology developed for space solar power. A propellant depot is described that will be deployed in a 400 km circular equatorial orbit, receive tanks of water launched into a lower orbit from Earth by gun launch or reusable launch vehicle, convert the water to liquid hydrogen and oxygen, and store Lip to 500 metric tonnes of cryogenic propellants. The propellant stored in the depot can support transportation from low Earth orbit to geostationary Earth orbit, the Moon, LaGrange points, Mars, etc. The tanks are configured in an inline gravity-gradient configuration to minimize drag and settle the propellant. Temperatures can be maintained by body-mounted radiators; these will also provide some shielding against orbital debris. Power is supplied by a pair of solar arrays mounted perpendicular to the orbital plane, which rotate once per orbit to track the Sun. In the longer term, cryogenic propellant production technology can be applied to a larger LEO depot, as well as to the use of lunar water resources at a similar depot elsewhere.

Subcutaneous and gonadal adipose tissue transcriptome differences in lean and obese female dogs.

PubMed

Grant, Ryan W; Vester Boler, Brittany M; Ridge, Tonya K; Graves, Thomas K; Swanson, Kelly S

2013-12-01

Canine obesity leads to shortened life span and increased disease incidence. Adipose tissue depots are known to have unique metabolic and gene expression profiles in rodents and humans, but few comparisons of depot gene expression have been performed in the dog. Using microarray technology, our objective was to identify differentially expressed genes and enriched functional pathways between subcutaneous and gonadal adipose of lean and obese dogs to better understand the pathogenesis of obesity in the dog. Because no depot × body weight status interactions were identified in the microarray data, depot differences were the primary focus. A total of 946 and 703 transcripts were differentially expressed (FDR P < 0.05) between gonadal and subcutaneous adipose tissue in obese and lean dogs respectively. Of the adipose depot-specific differences in gene expression, 162 were present in both lean and obese dogs, with the majority (85%) expressed in the same direction. Both lean and obese dog gene lists had enrichment of the complement and coagulation cascade and systemic lupus erythematosus pathways. Obese dogs had enrichment of lysosome, extracellular matrix-receptor interaction, renin-angiotensin system and hematopoietic cell lineage pathways. Lean dogs had enrichment of glutathione metabolism and synthesis and degradation of ketone bodies. We have identified a core set of genes differentially expressed between subcutaneous and gonadal adipose tissue in dogs regardless of body weight. These genes contribute to depot-specific differences in immune function, extracellular matrix remodeling and lysosomal function and may contribute to the physiological differences noted between depots. © 2013 The Authors, Animal Genetics © 2013 Stichting International Foundation for Animal Genetics.

Measurement of ground and nearby building vibration and noise induced by trains in a metro depot.

PubMed

Zou, Chao; Wang, Yimin; Wang, Peng; Guo, Jixing

2015-12-01

Metro depots are where subway trains are parked and where maintenance is carried out. They usually occupy the largest ground areas in metro projects. Due to land utilization problems, Chinese cities have begun to develop over-track buildings above metro depots for people's life and work. The frequently moving trains, when going into and out of metro depots, can cause excessive vibration and noise to over-track buildings and adversely affect the living quality of the building occupants. Considering the current need of reliable experimental data for the construction of metro depots, field measurements of vibration and noise on the ground and inside a nearby 3-story building subjected to moving subway trains were conducted in a metro depot at Guangzhou, China. The amplitudes and frequency contents of velocity levels were quantified and compared. The composite A-weighted equivalent sound levels and maximum sound levels were captured. The predicted models for vibration and noise of metro depot were proposed based on existing models and verified. It was found that the vertical vibrations were significantly greater than the horizontal vibrations on the ground and inside the building near the testing line. While at the throat area, the horizontal vibrations near the curved track were remarkably greater than the vertical vibrations. The attenuation of the vibrations with frequencies above 50 Hz was larger than the ones below 50 Hz, and the frequencies of vibration transmitting to adjacent buildings were mainly within 10-50 Hz. The largest equivalent sound level generated in the throat area was smaller than the testing line one, but the instantaneous maximum sound level induced by wheels squeal, contact between wheels and rail joints as well as turnout was close to or even greater than the testing line one. The predicted models gave a first estimation for design and assessment of newly built metro depots. Copyright © 2015 Elsevier B.V. All rights reserved.

MR signal-fat-fraction analysis and T2* weighted imaging measure BAT reliably on humans without cold exposure.

PubMed

Holstila, Milja; Pesola, Marko; Saari, Teemu; Koskensalo, Kalle; Raiko, Juho; Borra, Ronald J H; Nuutila, Pirjo; Parkkola, Riitta; Virtanen, Kirsi A

2017-05-01

Brown adipose tissue (BAT) is compositionally distinct from white adipose tissue (WAT) in terms of triglyceride and water content. In adult humans, the most significant BAT depot is localized in the supraclavicular area. Our aim is to differentiate brown adipose tissue from white adipose tissue using fat T2* relaxation time mapping and signal-fat-fraction (SFF) analysis based on a commercially available modified 2-point-Dixon (mDixon) water-fat separation method. We hypothesize that magnetic resonance (MR) imaging can reliably measure BAT regardless of the cold-induced metabolic activation, with BAT having a significantly higher water and iron content compared to WAT. The supraclavicular area of 13 volunteers was studied on 3T PET-MRI scanner using T2* relaxation time and SFF mapping both during cold exposure and at ambient temperature; and 18 F-FDG PET during cold exposure. Volumes of interest (VOIs) were defined semiautomatically in the supraclavicular fat depot, subcutaneous WAT and muscle. The supraclavicular fat depot (assumed to contain BAT) had a significantly lower SFF and fat T2* relaxation time compared to subcutaneous WAT. Cold exposure did not significantly affect MR-based measurements. SFF and T2* values measured during cold exposure and at ambient temperature correlated inversely with the glucose uptake measured by 18 F-FDG PET. Human BAT can be reliably and safely assessed using MRI without cold activation and PET-related radiation exposure. Copyright © 2017 Elsevier Inc. All rights reserved.

Where does hydrolysis of nandrolone decanoate occur in the human body after release from an oil depot?

PubMed

Kalicharan, R W; Bout, M R; Oussoren, C; Vromans, H

2016-12-30

Long-term therapy of nandrolone (N) is recommended to increase mineral density and muscle strength. Using a parenteral sustained release drug formulation with nandrolone decanoate (ND), therapeutic N levels can be achieved and maintained. Until now, it is unknown if hydrolysis of ND into N occurs in tissue at the injection site or after systemic absorption. Therefore, hydrolysis studies were conducted to investigate the location and rate of ND hydrolysis after its release from the oil depot. ND hydrolysis was studied in porcine tissues, to mimic the human muscular and subcutaneous tissues. Additionally, the ND hydrolysis was studied in human whole blood, plasma and serum at a concentration range of 23.3-233.3μM. ND hydrolysis only occurred in human whole blood. The hydrolysis did not start immediately, but after a lag time. The mean lag time for all studied concentrations was 34.9±2.5min. Because of a slow penetration into tissue, hydrolysis of ND is found to be very low in surrounding tissue. Therefore the local generation of the active compound is clinically irrelevant. It is argued that after injection of the oil depot, ND molecules will be transported via the lymphatic system towards lymph nodes. From here, it will enter the central circulation and within half an hour it will hydrolyse to the active N compound. Copyright © 2016 Elsevier B.V. All rights reserved.

Energy Engineering Analysis (EEA) program for Red River Army Depot, Texas. Executive summary. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The objectives of this Energy Engineering Analysis (EEA) for RRAD were three fold: Develop a systematic plan of projects which will result in reducing energy consumption. Consider renewable energy sources with the objective of establishing an orderly procedure for reducing use of non-renewable energy sources. Determine the feasibility of Total Energy (TE), Selective Energy (SE), and Central Heating Plant (CHP) concepts using alternative fuels. In essence, an assessment of the entire energy picture at RRAD was undertaken. This report is a summary of that effort. RRAD was originally built during 1941 and 1942 as a reserve ordnance depot for themore » Army. Since then, the missions and activities at RRAD have broadened to the point that it is now one of the largest Army depots in the continental United States. Located just west of Texarkana, Texas, RRAD encompasses an area of approximately 19,886 acres. The primary missions at RRAD are general supply and maintenance of vital Army equipment and ordnance material. The supply activities constitute the stocking, distribution, storage and supply of general Army supplies for the central region of the United States. Supply of vehicles, ammunition and guided missiles from RRAD encompasses a much larger region. The maintenance and repair functions at RRAD consists of the overhaul, modification, conversion and repair of automotive equipment and combat vehicles, missile systems and components, armament, and ammunition. Approximately 5500 people are currently employed at RRAD to carry out its mission.« less

45 CFR 671.13 - Waste management for the USAP.

Code of Federal Regulations, 2011 CFR

2011-10-01

....13 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... plans for waste reduction, storage and disposal) specifying for each of its permanent stations, field... past activities (i.e., traverses, fuel depots, field bases, crashed aircraft) so that such locations...

The MTA UXO Survey and Target Recovery on Lake Erie at the Former Erie Army Depot

DTIC Science & Technology

2009-12-01

MTA Demonstration Front Matter ii FIGURES 1. Firing fans and target locations for Erie Army Depot in 1965...triangles at the base of the image show the locations of the 15 fixed firing positions that were used for proof firing projectiles...the marshland adjacent to the firing ranges, and along beaches fronting the former Depot, (Reference 2, Appendices B and J).3-5 The impact areas

Artificial intelligence technology assessment for the US Army Depot System Command

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pennock, K A

1991-07-01

This assessment of artificial intelligence (AI) has been prepared for the US Army's Depot System Command (DESCOM) by Pacific Northwest Laboratory. The report describes several of the more promising AI technologies, focusing primarily on knowledge-based systems because they have been more successful in commercial applications than any other AI technique. The report also identifies potential Depot applications in the areas of procedural support, scheduling and planning, automated inspection, training, diagnostics, and robotic systems. One of the principal objectives of the report is to help decisionmakers within DESCOM to evaluate AI as a possible tool for solving individual depot problems. Themore » report identifies a number of factors that should be considered in such evaluations. 22 refs.« less

A 3/2-Approximation Algorithm for Multiple Depot Multiple Traveling Salesman Problem

NASA Astrophysics Data System (ADS)

Xu, Zhou; Rodrigues, Brian

As an important extension of the classical traveling salesman problem (TSP), the multiple depot multiple traveling salesman problem (MDMTSP) is to minimize the total length of a collection of tours for multiple vehicles to serve all the customers, where each vehicle must start or stay at its distinct depot. Due to the gap between the existing best approximation ratios for the TSP and for the MDMTSP in literature, which are 3/2 and 2, respectively, it is an open question whether or not a 3/2-approximation algorithm exists for the MDMTSP. We have partially addressed this question by developing a 3/2-approximation algorithm, which runs in polynomial time when the number of depots is a constant.

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... mine openings adjacent to the mine; (9) Locations of permanent underground shops, diesel fuel storage depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive...

A Study to Improve the Brazilian Air Force’s Material Management System

DTIC Science & Technology

1991-12-01

of Technology, in June 1990. Permanent Address: Base A6rea de Sio Paulo Instituto de Logistica da Aerongutica 07181 Guarulhos Sio Paulo Brazil 160 Vita...orders instead of more frequent smaller ones, and transportation from vendor to depot, which includes international fees in most cases, would be...optimized by the same reason. The transportation from depots to final users would not be affected, since only changes of depots and changes of material

Defense Depot Mechanicsburg Total Quality Management Implementation Plan

DTIC Science & Technology

1989-06-01

B T I TLEE 5 . FUNDING NUMBERS Defense Depot Mechanicsburg Total Quality Management Implementation Plan 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME...Form 298 (Rev. 2-89) L296- 102 Acces.ion For NYI J ... I:: ted DEFENSE DEPOT MECHANICSBURG PENNSYLVANIAL--I By_ TOTAL QUALITY MANAGEMENT K_~ t buty-n...IMPLEMENTATION PLAN Avmail-t!Ilty Codes IvLl c 2Dd/or JUN 3 0 1989 iDizt Special PURPOSE The purpose of this Total Quality Management Implementation

Injectable controlled release depots for large molecules

PubMed Central

Schwendeman, Steven P.; Shah, Ronak B.; Bailey, Brittany A.; Schwendeman, Anna S.

2014-01-01

Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few “real world” biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LAR products, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development. PMID:24929039

Triptorelin depot stimulation test for central precocious puberty.

PubMed

Strich, David; Kvatinsky, Noa; Hirsch, Harry J; Gillis, David

2013-01-01

Acute gonadotropin responses following depot leuprolide acetate injection are useful for monitoring therapeutic efficacy in central precocious puberty. Similar monitoring of therapy in patients treated with another widely used GnRH agonist, depot triptorelin, has not yet been reported. The objective of this study was to test the use of gonadotropin levels after therapeutic injections of depot triptorelin for evaluating efficacy of therapy. Thirty-two patients (29 girls and three boys) were treated with triptorelin depot, 3.75 mg per vial, between 2006 and 2010. Treatment was initiated at 8.27±1.76 years (range, 4.6-11.6 years). Blood was drawn before and at variable times between 30 min and 2 h after injections. Clinical tests were retrospectively collected. After the first injection, the 60-min mean luteinizing hormone (LH) level was 21.6.1±18.0 IU/L and the follicle-stimulating hormone (FSH) was 13.5±3.6 IU/L. After subsequent injections, for those who showed clinical suppression, the standard deviations above the mean were 3.6 IU/L for FSH and 2.1 IU/L for LH. The LH levels of two patients who did not suppress sufficiently were at these limits or higher. Sixty-minute postinjection depot triptorelin levels of LH can be successfully used to evaluate the efficacy of treatment with this agent. Limits for suppressed levels have been determined.

ERTS-1 DCS technical support provided by Wallops Station. [ground truth stations and DCP repair depot

NASA Technical Reports Server (NTRS)

Smith, R.

1975-01-01

Wallops Station accepted the tasks of providing ground truth to several ERTS investigators, operating a DCP repair depot, designing and building an airborne DCP Data Acquisition System, and providing aircraft underflight support for several other investigators. Additionally, the data bank is generally available for use by ERTS and other investigators that have a scientific interest in data pertaining to the Chesapeake Bay area. Working with DCS has provided a means of evaluating the system as a data collection device possibly applicable to ongoing Earth Resources Program activities in the Chesapeake Bay area as well as providing useful data and services to other ERTS investigators. The two areas of technical support provided by Wallops, ground truth stations and repair for DCPs, are briefly discussed.

DEPOT: A Database of Environmental Parameters, Organizations and Tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

CARSON,SUSAN D.; HUNTER,REGINA LEE; MALCZYNSKI,LEONARD A.

2000-12-19

The Database of Environmental Parameters, Organizations, and Tools (DEPOT) has been developed by the Department of Energy (DOE) as a central warehouse for access to data essential for environmental risk assessment analyses. Initial efforts have concentrated on groundwater and vadose zone transport data and bioaccumulation factors. DEPOT seeks to provide a source of referenced data that, wherever possible, includes the level of uncertainty associated with these parameters. Based on the amount of data available for a particular parameter, uncertainty is expressed as a standard deviation or a distribution function. DEPOT also provides DOE site-specific performance assessment data, pathway-specific transport data,more » and links to environmental regulations, disposal site waste acceptance criteria, other environmental parameter databases, and environmental risk assessment models.« less

Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue.

PubMed

Lecoutre, Simon; Deracinois, Barbara; Laborie, Christine; Eberlé, Delphine; Guinez, Céline; Panchenko, Polina E; Lesage, Jean; Vieau, Didier; Junien, Claudine; Gabory, Anne; Breton, Christophe

2016-07-01

According to the Developmental Origin of Health and Disease (DOHaD) concept, alterations of nutrient supply in the fetus or neonate result in long-term programming of individual body weight (BW) setpoint. In particular, maternal obesity, excessive nutrition, and accelerated growth in neonates have been shown to sensitize offspring to obesity. The white adipose tissue may represent a prime target of metabolic programming induced by maternal obesity. In order to unravel the underlying mechanisms, we have developed a rat model of maternal obesity using a high-fat (HF) diet (containing 60% lipids) before and during gestation and lactation. At birth, newborns from obese dams (called HF) were normotrophs. However, HF neonates exhibited a rapid weight gain during lactation, a key period of adipose tissue development in rodents. In males, increased BW at weaning (+30%) persists until 3months of age. Nine-month-old HF male offspring was normoglycemic but showed mild glucose intolerance, hyperinsulinemia, and hypercorticosteronemia. Despite no difference in BW and energy intake, HF adult male offspring was predisposed to fat accumulation showing increased visceral (gonadal and perirenal) depots weights and hyperleptinemia. However, only perirenal adipose tissue depot exhibited marked adipocyte hypertrophy and hyperplasia with elevated lipogenic (i.e. sterol-regulated element binding protein 1 (Srebp1), fatty acid synthase (Fas), and leptin) and diminished adipogenic (i.e. peroxisome proliferator-activated receptor gamma (Pparγ), 11β-hydroxysteroid dehydrogenase type 1 (11β-Hds1)) mRNA levels. By contrast, very few metabolic variations were observed in HF female offspring. Thus, maternal obesity and accelerated growth during lactation program offspring for higher adiposity via transcriptional alterations of visceral adipose tissue in a depot- and sex-specific manner. © 2016 Society for Endocrinology.

The nuclear retinoid-related orphan receptor RORα controls circadian thermogenic programming in white fat depots.

PubMed

Monnier, Chloé; Auclair, Martine; Le Cam, Gala; Garcia, Marie-Pauline; Antoine, Bénédicte

2018-04-01

The RORα-deficient staggerer (sg/sg) mouse is lean and resistant to diet-induced obesity. Its thermogenic activity was shown to be increased not only in brown adipose tissue (BAT), but also in subcutaneous white adipose tissue (WAT) where UCP1 content was enhanced, however, without Prdm16 coexpression. Our observation of partial multilocular lipid morphology of WAT in sg/sg mice both in the inguinal and perigonadal sites led us to focus on the phenotype of both fat depots. Because RORα is a nuclear factor acting in the clock machinery, we looked at the circadian expression profile of genes involved in thermogenesis and browning in WAT and BAT depots of sg/sg and WT mice, through real-time quantitative PCR and western blotting. This 24-h period approach revealed both a rhythmic expression of thermogenic genes in WAT and an increased browning of all the WAT depots tested in sg/sg mice that indeed involved the canonical browning process (through induction of Pgc-1α and Prdm16). This was associated with an enhanced isoproterenol-induced oxygen consumption rate of WAT explants from sg/sg mice, which was reproducible in WT explants by treatment with a RORα inverse agonist SR 3335, that induced a parallel increase in the UCP1 protein. Inhibitors of browning differentiation, such as TLE3 and RIP140, could be new targets of RORα that would be rather implicated in the whitening of adipocytes. Our study showed the pivotal role of RORα as an inhibitor of the thermogenic program in WAT, the role that could be counteracted in vivo with the RORα antagonists currently in development. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

A History of The North Pacific Division

DTIC Science & Technology

1991-01-01

elephants , producing power for the jack rabbits in the Columbia Basin. Concern over the lack of power markets prevented the Corps and the majority of...hangers that Bonneville and Grand Coulee would become white elephants . Declaring himself unequivocally in favor of early construction of Umatilla Dam, he...industry, engineers had to substitute wood for scarce steel whenever possible, and German prisoners of war from Rommel’s North African Corps traveled

Evaluation of Lower Umatilla River Channel Modifications Below Three Mile Dam, 1984 Annual Progress Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nigro, Anthony A.; Ward, David L.

1985-05-01

This report summarizes results of the first year of a study initiated in September 1984 to evaluate the adequacy of channel modifications made in the lower Umatilla River to improve adult anadromous salmonid passage to Three Mile Dam (RKm 5.6), determine if fish passage or delay problems exist at Three Mile Dam and recommend site specific corrective measures if needed. Movements of steelhead (Salmo gairdneri) were monitored using mark and recapture and radio telemetry techniques. Thirty-four steelhead were marked with T-anchor tags and released in the lower river. Fifteen of those marked were also fitted with radio transmitters. Three radiotaggedmore » steelhead migrated through channel modifications to Three Mile Dam. Two of these fish migrated to the dam in less than 26 hours, but held just below the dam for 7 and 10 days before entering the ladders. The third steelhead delayed for 30 days and entered the west ladder within 24 hours of arrival at the dam. Two other radiotagged steelhead moved upstream through some of the channel modifications but did not migrate to the dam. Only one of 19 marked steelhead not fitted with transmitters was recovered at Three Mile Dam. 14 refs., 18 figs., 3 tabs.« less

Aligning environmental management with ecosystem resilience: a First Foods example from the Confederated Tribes of the Umatilla Indian Reservation, Oregon, USA

USGS Publications Warehouse

Quaempts, Eric J; Jones, Krista; O'Daniel, Scott J.; Beechie, Timothy J.; Poole, Geoffrey C.

2018-01-01

The concept of “reciprocity” between humans and other biota arises from the creation belief of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR). The concept acknowledges a moral and practical obligation for humans and biota to care for and sustain one another, and arises from human gratitude and reverence for the contributions and sacrifices made by other biota to sustain human kind. Reciprocity has become a powerful organizing principle for the CTUIR Department of Natural Resources, fostering continuity across the actions and policies of environmental management programs at the CTUIR. Moreover, reciprocity is the foundation of the CTUIR “First Foods” management approach. We describe the cultural significance of First Foods, the First Foods management approach, a resulting management vision for resilient and functional river ecosystems, and subsequent shifts in management goals and planning among tribal environmental staff during the first decade of managing for First Foods. In presenting this management approach, we highlight how reciprocity has helped align human values and management goals with ecosystem resilience, yielding management decisions that benefit individuals and communities, indigenous and nonindigenous, as well as human and nonhuman. We further describe the broader applicability of reciprocity-based approaches to natural resource management.

Emplacement of Columbia River flood basalt

NASA Astrophysics Data System (ADS)

Reidel, Stephen P.

1998-11-01

Evidence is examined for the emplacement of the Umatilla, Wilbur Creek, and the Asotin Members of Columbia River Basalt Group. These flows erupted in the eastern part of the Columbia Plateau during the waning phases of volcanism. The Umatilla Member consists of two flows in the Lewiston basin area and southwestern Columbia Plateau. These flows mixed to form one flow in the central Columbia Plateau. The composition of the younger flow is preserved in the center and the composition of the older flow is at the top and bottom. There is a complete gradation between the two. Flows of the Wilbur Creek and Asotin Members erupted individually in the eastern Columbia Plateau and also mixed together in the central Columbia Plateau. Comparison of the emplacement patterns to intraflow structures and textures of the flows suggests that very little time elapsed between eruptions. In addition, the amount of crust that formed on the earlier flows prior to mixing also suggests rapid emplacement. Calculations of volumetric flow rates through constrictions in channels suggest emplacement times of weeks to months under fast laminar flow for all three members. A new model for the emplacement of Columbia River Basalt Group flows is proposed that suggests rapid eruption and emplacement for the main part of the flow and slower emplacement along the margins as the of the flow margin expands.

5. Photocopy titled 'Map of Naval Ammunition Depot, Bremerton (Puget ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photocopy titled 'Map of Naval Ammunition Depot, Bremerton (Puget Sound), Wash.' dated June 30, 1947. Buildings 103 and 104 are shaded and located left of center near top of map. HABS film is an 8x10' high-contrast negative made from original map in the collection of the Department of Public Works, Puget Sound Naval Shipyard, Bremerton, WA. - Puget Sound Naval Shipyard, Munitions Storage Bunker, Naval Ammunitions Depot, North of Campbell Trail, Bremerton, Kitsap County, WA

Optimizing biomass feedstock blends with respect to cost, supply, and quality for catalyzed and uncatalyzed fast pyrolysis applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Vicki S.; Aston, John E.; Lacey, Jeffrey A.

Here, biomass cost, quality and quantity are important parameters to consider when choosing feedstocks and locations for biorefineries. Biomass cost is dependent upon type, location, quantities available in a given area and logistics costs as well the quality needed for the biorefinery. Biomass quality depends upon type, growth conditions, weather, harvesting methods, storage conditions as well as any preprocessing methods used to improve quality. Biomass quantity depends heavily on location as well as growth conditions, weather, harvesting methods and storage conditions. This study examines how all three of these parameters affect the biomass mixture that is needed in a biomassmore » depot or biorefinery to achieve the lowest cost with the highest quality and at the quantities needed for biorefinery operation. Four biomass depots were proposed in South Carolina that would each process the predominant type of biomass available in that area and each produce 200,000 tons of feedstock per year. These depots would then feed a centrally located 800,000 ton biorefinery that would convert the feedstocks to pyrolysis oil using either catalyzed or uncatalyzed fast pyrolysis. The four depots each needed to produce different blends of biomass based upon the quantities available to them but still meet the minimum quality requirements for the biorefinery. Costs were minimized by using waste biomass resources such as construction and demolition waste, logging residues and forest residuals. Depending upon the quality specification required by the biorefinery, it was necessary to utilize preprocessing methods such as air classification and acid leaching to upgrade biomass quality. In the case of uncatalyzed fast pyrolysis, all four depots could produce biomass blends that were lower cost than the the preferred pyrolysis feedstock, clean pine, and meet quality and quantity specifications. For catalyzed fast pyrolysis, three of the four depots were able to produce blends that met both quality and quantity specifications at minimum cost. The fourth depot would not be able to produce a blend meeting specifications without increasing the supply radius for the depot.« less

Optimizing biomass feedstock blends with respect to cost, supply, and quality for catalyzed and uncatalyzed fast pyrolysis applications

DOE PAGES

Thompson, Vicki S.; Aston, John E.; Lacey, Jeffrey A.; ...

2017-05-24

Here, biomass cost, quality and quantity are important parameters to consider when choosing feedstocks and locations for biorefineries. Biomass cost is dependent upon type, location, quantities available in a given area and logistics costs as well the quality needed for the biorefinery. Biomass quality depends upon type, growth conditions, weather, harvesting methods, storage conditions as well as any preprocessing methods used to improve quality. Biomass quantity depends heavily on location as well as growth conditions, weather, harvesting methods and storage conditions. This study examines how all three of these parameters affect the biomass mixture that is needed in a biomassmore » depot or biorefinery to achieve the lowest cost with the highest quality and at the quantities needed for biorefinery operation. Four biomass depots were proposed in South Carolina that would each process the predominant type of biomass available in that area and each produce 200,000 tons of feedstock per year. These depots would then feed a centrally located 800,000 ton biorefinery that would convert the feedstocks to pyrolysis oil using either catalyzed or uncatalyzed fast pyrolysis. The four depots each needed to produce different blends of biomass based upon the quantities available to them but still meet the minimum quality requirements for the biorefinery. Costs were minimized by using waste biomass resources such as construction and demolition waste, logging residues and forest residuals. Depending upon the quality specification required by the biorefinery, it was necessary to utilize preprocessing methods such as air classification and acid leaching to upgrade biomass quality. In the case of uncatalyzed fast pyrolysis, all four depots could produce biomass blends that were lower cost than the the preferred pyrolysis feedstock, clean pine, and meet quality and quantity specifications. For catalyzed fast pyrolysis, three of the four depots were able to produce blends that met both quality and quantity specifications at minimum cost. The fourth depot would not be able to produce a blend meeting specifications without increasing the supply radius for the depot.« less

Detection of 11 beta-hydroxysteroid dehydrogenase type 1, the glucocorticoid and mineralocorticoid receptor in various adipose tissue depots of dairy cows supplemented with conjugated linoleic acids.

PubMed

Friedauer, K; Dänicke, S; Schulz, K; Sauerwein, H; Häussler, S

2015-10-01

Early lactating cows mobilize adipose tissue (AT) to provide energy for milk yield and maintenance and are susceptible to metabolic disorders and impaired immune response. Conjugated linoleic acids (CLA), mainly the trans-10, cis-12 isomer, reduce milk fat synthesis and may attenuate negative energy balance. Circulating glucocorticoids (GC) are increased during parturition in dairy cows and mediate differentiating and anti-inflammatory effects via glucocorticoid (GR) and mineralocorticoid receptors (MR) in the presence of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1). Activated GC are the main ligands for both receptors in AT; therefore, we hypothesized that tissue-specific GC metabolism is effected by varying amounts of GR, MR and 11βHSD1 and/or their localization within AT depots. Furthermore, the lipolytic and antilipogenic effects of CLA might influence the GC/GR/MR system in AT. Therefore, we aimed to localize GR and MR as well as the expression pattern and activity of 11βHSD1 in different AT depots during early lactation in dairy cows and to identify potential effects of CLA. Primiparous German Holstein cows were divided into a control (CON) and a CLA group. From day 1 post-partum (p.p.) until sample collection, the CLA group was fed with 100 g/d CLA (contains 10 g each of the cis-9, trans-11 and the trans-10, cis-12-CLA isomers). CON cows (n = 5 each) were slaughtered on day 1, 42 and 105 p.p., while CLA cows (n = 5 each) were slaughtered on day 42 and 105 p.p. Subcutaneous fat from tailhead, withers and sternum, and visceral fat from omental, mesenteric and retroperitoneal depots were sampled. The localization of GR and 11βHSD1 in mature adipocytes - being already differentiated - indicates that GC promote other effects via GR than differentiation. Moreover, MR were observed in the stromal vascular cell fraction and positively related to the pre-adipocyte marker Pref-1. However, only marginal CLA effects were observed in this study. Journal of Animal Physiology and Animal Nutrition © 2014 Blackwell Verlag GmbH.

44. Storehouse of Philadelphia Signal Depot, U.S. Army Corps of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Storehouse of Philadelphia Signal Depot, U.S. Army Corps of Engineers, War Department (1942) - Atwater Kent Manufacturing Company, North Plant, 5000 Wissahickon Avenue, Philadelphia, Philadelphia County, PA

Thyroid Dysfunction Associated With Follicular Cell Steatosis in Obese Male Mice and Humans

PubMed Central

Lee, Min Hee; Lee, Jung Uee; Joung, Kyong Hye; Kim, Yong Kyung; Ryu, Min Jeong; Lee, Seong Eun; Kim, Soung Jung; Chung, Hyo Kyun; Choi, Min Jeong; Chang, Joon Young; Lee, Sang-Hee; Kweon, Gi Ryang; Kim, Hyun Jin; Kim, Koon Soon; Kim, Seong-Min; Jo, Young Suk; Park, Jeongwon; Cheng, Sheue-Yann

2015-01-01

Adult thyroid dysfunction is a common endocrine disorder associated with an increased risk of cardiovascular disease and mortality. A recent epidemiologic study revealed a link between obesity and increased prevalence of hypothyroidism. It is conceivable that excessive adiposity in obesity might lead to expansion of the interfollicular adipose (IFA) depot or steatosis in thyroid follicular cells (thyroid steatosis, TS). In this study, we investigated the morphological and functional changes in thyroid glands of obese humans and animal models, diet-induced obese (DIO), ob/ob, and db/db mice. Expanded IFA depot and TS were observed in obese patients. Furthermore, DIO mice showed increased expression of lipogenesis-regulation genes, such as sterol regulatory element binding protein 1 (SREBP-1), peroxisome proliferator-activated receptor γ (PPARγ), acetyl coenzyme A carboxylase (ACC), and fatty acid synthetase (FASN) in the thyroid gland. Steatosis and ultrastructural changes, including distension of the endoplasmic reticulum (ER) and mitochondrial distortion in thyroid follicular cells, were uniformly observed in DIO mice and genetically obese mouse models, ob/ob and db/db mice. Obese mice displayed a variable degree of primary thyroid hypofunction, which was not corrected by PPARγ agonist administration. We propose that systemically increased adiposity is associated with characteristic IFA depots and TS and may cause or influence the development of primary thyroid failure. PMID:25555091

Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis.

PubMed

Albaugh, V L; Judson, J G; She, P; Lang, C H; Maresca, K P; Joyal, J L; Lynch, C J

2011-05-01

Olanzapine and other atypical antipsychotics cause metabolic side effects leading to obesity and diabetes; although these continue to be an important public health concern, their underlying mechanisms remain elusive. Therefore, an animal model of these side effects was developed in male Sprague-Dawley rats. Chronic administration of olanzapine elevated fasting glucose, impaired glucose and insulin tolerance, increased fat mass but, in contrast to female rats, did not increase body weight or food intake. Acute studies were conducted to delineate the mechanisms responsible for these effects. Olanzapine markedly decreased physical activity without a compensatory decline in food intake. It also acutely elevated fasting glucose and worsened oral glucose and insulin tolerance, suggesting that these effects are adiposity independent. Hyperinsulinemic-euglycemic clamp studies measuring (14)C-2-deoxyglucose uptake revealed tissue-specific insulin resistance. Insulin sensitivity was impaired in skeletal muscle, but either unchanged or increased in adipose tissue depots. Consistent with the olanzapine-induced hyperglycemia, there was a tendency for increased (14)C-2-deoxyglucose uptake into fat depots of fed rats and, surprisingly, free fatty acid (FFA) uptake into fat depots was elevated approximately twofold. The increased glucose and FFA uptake into adipose tissue was coupled with increased adipose tissue lipogenesis. Finally, olanzapine lowered fasting plasma FFA, and as it had no effect on isoproterenol-stimulated rises in plasma glucose, it blunted isoproterenol-stimulated in vivo lipolysis in fed rats. Collectively, these results suggest that olanzapine exerts several metabolic effects that together favor increased accumulation of fuel into adipose tissue, thereby increasing adiposity.

Distribution depot revenues

DOT National Transportation Integrated Search

1998-02-13

The issue of Distribution Depot revenues was identified during our audit of the revenue accounts in the FY 1996 Defense Business Operations Fund financial statements (the revenue accounts audit). The revenue accounts audit was initiated to support th...

NPDES Permit for Wulf Cattle Depot in South Dakota

EPA Pesticide Factsheets

Under NPDES permit SD-0034606, the Wulf Cattle Depot is authorized to discharge and must operate their facility in accordance with effluent limitations, monitoring requirements, and other provisions set forth herein.

Computerized LCC/ORLA methodology. [Life cycle cost/optimum repair level analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henderson, J.T.

1979-01-01

The effort by Sandia Laboratories in developing CDC6600 computer programs for Optimum Repair Level Analysis (ORLA) and Life Cycle Cost (LCC) analysis is described. Investigation of the three repair-level strategies referenced in AFLCM/AFSCM 800-4 (base discard of subassemblies, base repair of subassemblies, and depot repair of subassemblies) was expanded to include an additional three repair-level strategies (base discard of complete assemblies and, upon shipment of complete assemblies to the depot, depot repair of assemblies by subassembly repair, and depot repair of assemblies by subassembly discard). The expanded ORLA was used directly in an LCC model that was procedurally altered tomore » accommodate the ORLA input data. Available from the LCC computer run was an LCC value corresponding to the strategy chosen from the ORLA. 2 figures.« less

Thermal Examination of an Orbiting Cryogenic Fuel Depot

NASA Technical Reports Server (NTRS)

Hull, Patrick V.; Canfield, Steven L.; Carrington, Connie; Fikes, John

2002-01-01

For many years NASA has been interested in the storage and transfer of cryogenic fuels in space. Lunar, L2 and other chemical propulsive space vehicle missions now have staged refueling needs that a fuel depot would satisfy. The depot considered is located in lower earth orbit. Many considerations must go into designing and building such a station. Multi-layer insulation systems, thermal shielding and low conductive structural supports are the principal means of protecting the system from excessive heat loss due to boiloff. This study focuses on the thermal losses associated with storing LH2 in a passively cooled fuel depot in a lower earth equatorial orbit. The corresponding examination looks at several configurations of the fuel depot. An analytical model has been developed to determine the thermal advantages and disadvantages of three different fuel depot configurations. Each of the systems consists of three Boeing rocket bodies arranged in various configurations. The first two configurations are gravity gradient stabilized while the third one is a spin-stabilized concept. Each concept was chosen for self-righting capabilities as well as the fuel settling capabilities, however the purpose of this paper is to prove which of the three concepts is the most efficient passively cooled system. The specific areas to be discussed are the heating time from the fusion temperature to the vaporization temperature and the amount of boiloff for a specific number of orbits. Each of the previous points is compared using various sun exposed surface areas of the tanks.

Abdominal fat sub-depots and energy expenditure: Magnetic resonance imaging study.

PubMed

Serfaty, Dana; Rein, Michal; Schwarzfuchs, Dan; Shelef, Ilan; Gepner, Yftach; Bril, Nitzan; Cohen, Noa; Shemesh, Elad; Sarusi, Benjamin; Kovsan, Julia; Kenigsbuch, Shira; Chassidim, Yoash; Golan, Rachel; Witkow, Shula; Henkin, Yaakov; Stampfer, Meir J; Rudich, Assaf; Shai, Iris

2017-06-01

We aimed to assess the association between the distinct abdominal sub-depots and resting energy expenditure (REE). We performed magnetic resonance imaging (MRI) to quantify abdominal visceral-adipose-tissue (VAT), deep-subcutaneous-adipose-tissue (deep-SAT), and superficial-subcutaneous-adipose-tissue (superficial-SAT). We measured REE by indirect-calorimetry. Non-exercise activity thermogenesis (NEAT) [1-3 metabolic equivalents (METs)] and exercise thermogenesis (activities of 4+MET S ) were estimated based on 6-days of accelerometry to assess total physical activity energy expenditure (PAEE). We studied 282 participants: 249 men [mean age = 47.4 years, body-mass-index (BMI) = 31 kg/m 2 , mean VAT proportion from total abdominal fat = 34.5%, mean superficial-SAT proportion from total abdominal fat = 24.3%] and 33 women (mean age = 51.2 years, BMI = 30.1 kg/m 2 , mean VAT proportion from total abdominal fat = 22.8%, mean superficial-SAT proportion from total abdominal fat = 37.8%). As expected, women had lower REE [by 32.4% (1488 ± 234 kcal/day vs. 1971 ± 257 kcal/day; p < 0.01)] and lower REE/kg [by 8% (19.6 ± 3 kcal/kg vs. 21.2 ± 2 kcal/kg; p < 0.01)] than men. Exercise and total PAEE were positively associated with REE/kg (p < 0.01 for both) and a positive correlation between NEAT and REE/kg was borderline (p = 0.056). Participants, in whom abdominal VAT was the dominant proportional depot, had higher REE (1964 ± 297 kcal/day vs. 1654 ± 352 kcal/day; p < 0.01) and higher REE∖kg (22.2 ± 2.3 kcal/kg/day vs. 19.6 ± 2.5 kcal/kg/day; p < 0.01) than participants in whom superficial-SAT was the largest proportional depot. In multivariate models, adjusted for age, gender and residual BMI, increased VAT proportion was independently associated with higher REE (β = 0.181; p = 0.05). Likewise, increased VAT proportion (β = 0.482; p < 0.01) remained independently associated with higher REE/kg. In this model younger age (β = -0.329; p < 0.01) was associated with higher REE/kg. Abdominal fat distribution patterns are associated with varying levels of resting energy expenditure, potentially reflecting different metabolic rates of adipose sub-depots and providing an anatomic/anthropometric link to physiological obese sub-phenotypes. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Department of Defense Agency Financial Report for FY 2010

DTIC Science & Technology

2010-11-15

operations, exceeded nearly $700 billion. This total is more than double the last DoD budget preceding September 11, 2001. Keeping pace with this...this trend, the Department is re-focusing on the nuclear enterprise. The Department continues to analyze and identify key deficiencies and methods ...Depot Maintenance and Ordnance WCF activities recognize revenue according to the percentage of completion method . Supply Management WCF activities

SUPERFUND TREATABILITY CLEARINGHOUSE: INCINERATION TEST OF EXPLOSIVES CONTAMINATED SOILS AT SAVANNA ARMY DEPOT ACTIVITY, SAVANNA, ILLINOIS

EPA Science Inventory

The primary objective of these tests was to demonstrate the effectiveness of incineration as a decontamination method for explosives contaminated sails. A pilot-scale rotary kiln incinerator, manufactured by ThermAll, Inc., was used to treat both sandy and clayey...

78 FR 52511 - Procurement List; Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

..., W7NX USPFO Activity PA ARNG, Annville, PA. Service Type/Location: Integrated Prime Vendor Supply Chain... of PM FSS, does not have a current contract for the provision of Integrated Prime Vendor Supply Chain... kitting or other supply chain management services required were obtained through the DLA depot system. The...

Field test on the treatment of source zone chloroethenes using emulsified zerovalent iron

EPA Science Inventory

This talk summarizes the research activities currently underway at the Solid Waste Management Unit 45 (Site 45), Marine Corps Recruit Depot, Parris Island, South Carolina. A pilot field test was initiated in 2005 at this site to evaluate the effectiveness of nanoscale emulsified...

Six-month gonadotropin releasing hormone (GnRH) agonist depots provide efficacy, safety, convenience, and comfort

PubMed Central

Crawford, E David; Phillips, Jason M

2011-01-01

Two different 6-month GnRH agonist depot formulations approved for palliative treatment of advanced and metastatic prostate cancer in the United States – leuprolide acetate 45 mg and triptorelin pamoate 22.5 mg – provide patients with efficacy and safety comparable to those of existing 1-, 3-, and 4-month GnRH agonist depots. However, the 6-month formulations can increase patient convenience, comfort, and compliance by reducing the number of physician visits and injections required. At the conclusion of their pivotal trials, the 6-month formulations demonstrated efficacy rates in achieving chemical castration (serum testosterone ≤50 ng/dL) that ranged between 93% and 99%. As with existing GnRH agonist depot formulations, hot flashes represented the most common adverse event reported in trials of 6-month leuprolide acetate or triptorelin. As such, these products may prove useful not only for their labeled indication, but also as adjuncts to other treatments such as radical prostatectomy, radiotherapy, and chemotherapy. We recommend further research, including head-to-head trials between the 6-month GnRH depots, to refine our understanding of these products. PMID:21847353

Visualization of subcutaneous insulin injections by x-ray computed tomography

NASA Astrophysics Data System (ADS)

Thomsen, M.; Poulsen, M.; Bech, M.; Velroyen, A.; Herzen, J.; Beckmann, F.; Feidenhans'l, R.; Pfeiffer, F.

2012-11-01

We report how the three-dimensional structure of subcutaneous injections of soluble insulin can be visualized by x-ray computed tomography using an iodine based contrast agent. The injections investigated are performed ex vivo in porcine adipose tissue. Full tomography scans carried out at a laboratory x-ray source with a total acquisition time of about 1 min yield CT-images with an effective pixel size of 109 × 109 μm2. The depots are segmented using a modified Chan-Vese algorithm and we are able to observe differences in the shape of the injection depot and the position of the depot in the skin among equally performed injections. To overcome the beam hardening artefacts, which affect the quantitative prediction of the volume injected, we additionally present results concerning the visualization of two injections using synchrotron radiation. The spatial concentration distribution of iodine is calculated to show the dilution of the insulin drug inside the depot. Characterisation of the shape of the depot and the spatial concentration profile of the injected fluid is important knowledge when improving the clinical formulation of an insulin drug, the performance of injection devices and when predicting the effect of the drug through biomedical simulations.

Orbiting Depot and Reusable Lander for Lunar Transportation

NASA Technical Reports Server (NTRS)

Petro, Andrew

2009-01-01

A document describes a conceptual transportation system that would support exploratory visits by humans to locations dispersed across the surface of the Moon and provide transport of humans and cargo to sustain one or more permanent Lunar outpost. The system architecture reflects requirements to (1) minimize the amount of vehicle hardware that must be expended while maintaining high performance margins and (2) take advantage of emerging capabilities to produce propellants on the Moon while also enabling efficient operation using propellants transported from Earth. The system would include reusable single- stage lander spacecraft and a depot in a low orbit around the Moon. Each lander would have descent, landing, and ascent capabilities. A crew-taxi version of the lander would carry a pressurized crew module; a cargo version could carry a variety of cargo containers. The depot would serve as a facility for storage and for refueling with propellants delivered from Earth or propellants produced on the Moon. The depot could receive propellants and cargo sent from Earth on a variety of spacecraft. The depot could provide power and orbit maintenance for crew vehicles from Earth and could serve as a safe haven for lunar crews pending transport back to Earth.

Development of a Lunar Consumables Storage and Distribution Depot

NASA Technical Reports Server (NTRS)

Mueller, Robert P.; Notardonato, William

2004-01-01

NASA is in the preliminary planning stages for a future lunar base as a response to President George W. Bush's recent announcement of a new sustained exploration program beyond low earth orbit. Kennedy Space Center engineers are supporting this program by utilizing experience in Spaceport system design and operations to help develop a Lunar Consumables Depot. This depot will store propellants, life support fluids, and other consumables either transported from Earth or manufactured from In Situ resources. The depot will distribute these consumables in an energy efficient manner to end users including spacecraft, habitation modules, and rovers. This paper addresses some of the changes to lunar base architecture design as a result of advances in knowledge of lunar resources over the past 35 years, as well as technology advances in the area of In Situ Resource Utilization and consumable storage and distribution. A general system level description of the depot will be presented, including overall design philosophy and high level requirements. Finally, specific subsystem technologies that have been or will be developed by KSC will be addressed. Examples of these technologies are automated umbilicals, cryogenic refrigerators, novel storage vessels, advanced heat switches and heat exchangers, and self healing gaskets and wires.

U.S. Naval Base, Pearl Harbor, Naval Ammunition Depot West Loch, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

U.S. Naval Base, Pearl Harbor, Naval Ammunition Depot West Loch, Oahu, Dispensary, Near Avenue A between First & Second Streets, Lualualei, West Loch Branch Naval Magazine, Pearl City, Honolulu County, HI

Radiological Final Status Survey of the Hammond Depot, Hammond, Indiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

T.J. Vitkus

2008-04-07

ORISE conducted extensive scoping, characterization, and final status surveys of land areas and structures at the DNSC’s Hammond Depot located in Hammond, Indiana in multiple phases during 2005, 2006 and 2007.

Adipose tissue and inflammatory bowel disease pathogenesis.

PubMed

Fink, Christopher; Karagiannides, Iordanes; Bakirtzi, Kyriaki; Pothoulakis, Charalabos

2012-08-01

Creeping fat has long been recognized as an indicator of Crohn's disease (CD) activity. Although most patients with CD have normal or low body mass index (BMI), the ratio of intraabdominal fat to total abdominal fat is far greater than that of controls. The obesity epidemic has instructed us on the inflammatory nature of hypertrophic adipose tissue and similarities between mesenteric depots in obese and CD patients can be drawn. However, several important physiological differences exist between these two depots as well. While the molecular basis of the crosstalk between mesenteric adipose and the inflamed intestine in CD is largely unknown, novel evidence implicates neuropeptides along with adipocyte-derived paracrine mediators (adipokines) as potential targets for future investigations and highlight adipose tissue physiology as a potential important determinant in the course of IBD. Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.

Guidelines for establishing a donor human milk depot.

PubMed

Geraghty, Sheela R; List, Betsy A; Morrow, Georgia B

2010-02-01

Human milk is the preferred choice for infant feeding. When a sick or premature infant's own mother's milk is unavailable, donor human milk is becoming more widely used. Many potential milk donors do not live within close proximity to the 10 North American not-for-profit milk banks. Transporting milk via commercial carriers can be inconvenient and costly for recipient banks. A network of donor human milk depots is one practical way to increase the quantity of available donor human milk. This article provides guidelines and practical suggestions for establishing a donor human milk depot.

Development and Adaptation of A Control System for Optimization of Single and Multiple Operation Machining

DTIC Science & Technology

1974-06-01

015C 0151 015*: 0152 0154 0155 015* 0157 015C 015S OUC 2010 2011 2012 2006 2^li «14 2ol5 2016 2017 C c c lul3 2018 2019 20*1...AHN: AMXPE-MT Rock Island Arsenal Rock Island, IL 61201 2 Director USAMC Intern Training Center AHN: AMXMC-ITC-PPE Red River Army Depot Texarkana ...River Army Depot ATTN: AMXRR-KM Texarkana , TX 75501 1 Commander Sacramento Army Depot ATTN: AMXSA-MME-LB Sacramento, CA 95813 1 Commander

An Analysis of the Factors Generating the Variance Between the Budgeted and Actual Operating Results of the Naval Aviation Depot at North Island, California

DTIC Science & Technology

2008-06-01

management structure employs free- market system principles and encourages business-like processes that are mission driven. Since no operating funds are...variable (Potvin, 2007). 2. Unit Cost Goal NWCFs use the unit cost goal ( UCG ) for planning purposes. The UCG is an estimate of what a unit of product...mission 6. Will not interfere with depot performance This section opens the depot to the private market . 53 Chapter 159 – Real Property

F-16X MSIP (Multi-National Staged Improvement Program) Case Example: Operating and Support Cost Estimation Using VAMOSC (Visibility and Management of Operating and Support Costs).

DTIC Science & Technology

1984-08-17

MODIFICATION-SPECIFIC RELIABILITY SCALAR DERIVATION A 8 C MOD LDZfl 11-R P-1F SI RZLaB.=l sUC NOD # 0g5SXpnflWIP rH SCALAR 1. 42DC 0822 Provide Direct 1964...WSSC Cost x F-16X MSIP Depot Avionics Maint.Mat F-16A Depot Avionics Maint.Materiel - $.028M x $81 297 liT2-2,000 = $. 103M /Squadron/Year C-1O DEPOT

The Results of a Laboratory Feasibility Study for the Biological Treatment of Umatilla Groundwater

DTIC Science & Technology

2012-01-01

high fructose corn syrup Kroger brand lactose Columbia River Processors, Boardman, OR cheese whey Columbia River Processors, Boardman, OR lactate...Processing Roy Dugan 541·481-3771 79588 Rippee Road 55 High Fructose Corn Syrup Malt Products Corp. Joanne McGuire 530-677-8282 #677 Blackstrap...communication with experts) tested in Run 1 were: • high - fructose corn sugar (based on promising results obtained using soft drink by-products

Cost-Effectiveness of Financial Incentives to Promote Adherence to Depot Antipsychotic Medication: Economic Evaluation of a Cluster-Randomised Controlled Trial

PubMed Central

Henderson, Catherine; Knapp, Martin; Yeeles, Ksenija; Bremner, Stephen; Eldridge, Sandra; David, Anthony S.; O’Connell, Nicola; Burns, Tom; Priebe, Stefan

2015-01-01

Background Offering a modest financial incentive to people with psychosis can promote adherence to depot antipsychotic medication, but the cost-effectiveness of this approach has not been examined. Methods Economic evaluation within a pragmatic cluster-randomised controlled trial. 141 patients under the care of 73 teams (clusters) were randomised to intervention or control; 138 patients with diagnoses of schizophrenia, schizo-affective disorder or bipolar disorder participated. Intervention participants received £15 per depot injection over 12 months, additional to usual acute, mental and community primary health services. The control group received usual health services. Main outcome measures: incremental cost per 20% increase in adherence to depot antipsychotic medication; incremental cost of ‘good’ adherence (defined as taking at least 95% of the prescribed number of depot medications over the intervention period). Findings Economic and outcome data for baseline and 12-month follow-up were available for 117 participants. The adjusted difference in adherence between groups was 12.2% (73.4% control vs. 85.6% intervention); the adjusted costs difference was £598 (95% CI -£4 533, £5 730). The extra cost per patient to increase adherence to depot medications by 20% was £982 (95% CI -£8 020, £14 000). The extra cost per patient of achieving 'good' adherence was £2 950 (CI -£19 400, £27 800). Probability of cost-effectiveness exceeded 97.5% at willingness-to-pay values of £14 000 for a 20% increase in adherence and £27 800 for good adherence. Interpretation Offering a modest financial incentive to people with psychosis is cost-effective in promoting adherence to depot antipsychotic medication. Direct healthcare costs (including costs of the financial incentive) are unlikely to be increased by this intervention. Trial Registration ISRCTN.com 77769281 PMID:26448540

Modeling the wet bulb globe temperature using standard meteorological measurements.

PubMed

Liljegren, James C; Carhart, Richard A; Lawday, Philip; Tschopp, Stephen; Sharp, Robert

2008-10-01

The U.S. Army has a need for continuous, accurate estimates of the wet bulb globe temperature to protect soldiers and civilian workers from heat-related injuries, including those involved in the storage and destruction of aging chemical munitions at depots across the United States. At these depots, workers must don protective clothing that increases their risk of heat-related injury. Because of the difficulty in making continuous, accurate measurements of wet bulb globe temperature outdoors, the authors have developed a model of the wet bulb globe temperature that relies only on standard meteorological data available at each storage depot for input. The model is composed of separate submodels of the natural wet bulb and globe temperatures that are based on fundamental principles of heat and mass transfer, has no site-dependent parameters, and achieves an accuracy of better than 1 degree C based on comparisons with wet bulb globe temperature measurements at all depots.

Global adiposity and thickness of intraperitoneal and mesenteric adipose tissue depots are increased in women with polycystic ovary syndrome (PCOS).

PubMed

Borruel, Susana; Fernández-Durán, Elena; Alpañés, Macarena; Martí, David; Alvarez-Blasco, Francisco; Luque-Ramírez, Manuel; Escobar-Morreale, Héctor F

2013-03-01

Sexual dimorphism suggests a role for androgens in body fat distribution. Women with polycystic ovary syndrome (PCOS), a mainly androgen excess disorder, often present with abdominal obesity and visceral adiposity. We hypothesized that women with PCOS have a masculinized body fat distribution favoring the deposition of fat in visceral and organ-specific adipose tissue depots. This was a case-control study. The study was conducted at an academic hospital. Women with PCOS (n = 55), women without androgen excess (n = 25), and men (n = 26) presenting with similar body mass index participated in the study. There were no interventions. Ultrasound measurements of adipose tissue depots including sc (minimum and maximum), preperitoneal, ip, mesenteric, epicardial, and perirenal fat thickness were obtained and total body fat mass was estimated using a body fat monitor. Men and patients with PCOS had increased amounts of total body fat compared with control women. Men had increased thickness of intraabdominal adipose tissue depots compared with the control women, with the women with PCOS showing intermediate values that were also higher than those of control women in the case of ip and mesenteric fat thickness and was close to reaching statistical significance in the case of epicardial fat thickness. Women with PCOS also showed increased minimum sc fat thickness compared with the control women. Obesity increased the thickness of all of the adipose tissue depots in the 3 groups of subjects. Women with PCOS have higher global adiposity and increased amounts of visceral adipose tissue compared with control women, especially in the ip and mesenteric depots.

Hypoxia induced VEGF synthesis in visceral adipose depots of obese diabetic patients.

PubMed

Fusaru, Ana Marina; Pisoschi, Cătălina Gabriela; Bold, Adriana; Taisescu, C; Stănescu, R; Hîncu, Mihaela; Crăiţoiu, Stefania; Baniţă, Ileana Monica

2012-01-01

VEGF is one the pro-inflammatory adipokines synthesized by the "adipose secretoma" of obese subjects as a response to hypoxic conditions; but the main function of VEGF is angiogenesis, being recognized as the most important factor increasing blood capillaries in the adipose tissue by stimulating endothelial cell growth. In this paper, we propose a comparative study of the vascular response to VEGF synthesis in the subcutaneous and central-peritoneal adipose depots in lean, obese and obese diabetic patients. We used CD31 to label the endothelial cells in order to evaluate the response of the vascular network to VEGF synthesis. Our results showed an increase of VEGF protein synthesis in obese and obese-diabetic patients compared to lean subjects where the protein was absent. The positivity for VEGF in obese diabetic samples was observed in numerous structures from the adipose depots, both in the stromal vascular fraction--blood vessels and stromal cells--as well as in the cytoplasm of adipocytes. Positivity in the vascular wall was observed more frequently in areas of perivascular and intralobular fibrosis. Obese and diabetic patients showed similar incidence of CD31 immunoreactivity with lean subjects in both subcutaneous and peritoneal depots. In conclusion, human adipose depots show a different incidence of VEGF positive cells in relation with their disposal and the metabolic status. VEGF synthesis in visceral adipose tissue is inefficient being not followed by angiogenesis to counterbalance tissue hypoxia. We suggest that may be a pathogenic link between the degrees of intralobular fibrosis in adipose depots and VEGF expression.

Groundwater status and trends for the Columbia Plateau Regional Aquifer System, Washington, Oregon, and Idaho

USGS Publications Warehouse

Burns, Erick R.; Snyder, Daniel T.; Haynes, Jonathan V.; Waibel, Michael S.

2012-01-01

Well information and groundwater-level measurements for the Columbia Plateau Regional Aquifer System in Washington, Oregon, and Idaho, were compiled from data provided by the U.S. Geological Survey and seven other organizations. From the full set of about 60,000 wells and 450,000 water-level measurements a subset of 761 wells within the aquifers of the Columbia River Basalt Group (CRBG) then was used to develop a simple linear groundwater-level trend map for 1968–2009. The mean of the trends was a decline of 1.9 feet per year (ft/yr), with 72 percent of the water levels in wells declining. Rates of declines greater than 1.0 ft/yr were measured in 50 percent of wells, declines greater than 2.0 ft/yr in 38 percent of wells, declines greater than 4.0 ft/yr in 29 percent of wells, and declines greater than 8.0 ft/yr in 4 percent of wells. Water-level data were used to identify groups of wells with similar hydraulic heads and temporal trends to delineate areas of overall similar groundwater conditions. Discontinuities in hydraulic head between well groups were used to help infer the presence of barriers to groundwater flow such as changes in lithology or the occurrence of folds and faults. In areas without flow barriers, dissimilarities in response of well groups over time resulted from the formation of groundwater mounds caused by recharge from irrigation or regions of decline caused by pumping. The areas of focus for this analysis included the Umatilla area, Oregon, and the Palouse Slope/eastern Yakima Fold Belt in the Columbia Basin Ground Water Management Area (GWMA) consisting of Adams, Franklin, Grant, and Lincoln Counties, Washington. In the Umatilla area, water levels from 286 wells were used to identify multiple areas of high hydraulic gradient that indicate vertical and horizontal barriers to groundwater flow. These barriers divide the groundwater-flow system into several compartments with varying degrees of interconnection. Horizontal flow barriers commonly correspond to mapped geologic structure and result in horizontal hydraulic gradients that progressively become steeper from north to south corresponding to an increase in structural complexity that may be impeding recharge from the uplands into the heavily developed areas. Most CRBG aquifers in the Umatilla area are declining and since 1970, cumulative declines range from about 100 to 300 feet. Significant vertical hydraulic gradients are documented for relatively small areas near Umatilla, and since the 1970s, downward vertical gradients in these areas have been increasing as hydraulic heads in the deeper units have declined. The absence of vertical gradients over much of the area may be a consequence of flow through commingling wells that results in the equilibration of the heads between aquifers. On the Palouse Slope in the central GWMA, large groundwater declines occurred during 1968–2009 along a north-south swath in the middle of the region. An analysis of 1,195 wells along major flow paths and through the area of persistent groundwater-level declines indicates that barriers to flow are not as evident in this area as in Umatilla. This is consistent with the geologic interpretation of the Palouse Slope as being a gently folded structure created by voluminous sheet flows of CRBG lavas. Groundwater discharge into the sediment-filled coulees, where the upper aquifers are intersected at land surface by incised canyons, is proposed as an alternative to explain local steepening of the hydraulic gradient along the Palouse Slope previously attributed to the presence of a groundwater dam. Comparison of generalized potentiometric surface maps developed for pre-development conditions and post-2000 conditions indicate that pre-development groundwater flow was from the uplands toward the Columbia and Snake River and that post-2000 flow patterns in the area are controlled by irrigation practices that have resulted in broad regions of elevated or depressed hydraulic head. In some cases, irrigation-related changes in head have reversed groundwater flow directions. Evidence of significant vertical hydraulic gradients exists, although much of the aquifer thickness is affected by commingling of wells. The effect of commingling and its relative contribution to problems related to groundwater-level declines remains unclear.

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

30 CFR 57.8520 - Ventilation plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... depots, oil fuel storage depots, hoist rooms, compressors, battery charging stations and explosive... and booster fans including manufacturer's name, type, size, fan speed, blade setting, approximate... sketches showing how ventilation is accomplished in each typical type of working place including the...

Improving Warehouse Inventory Management Through Rfid, Barcoding and Robotics Technologies

DTIC Science & Technology

2014-12-01

as a spider merge. This was designed and installed to speed up the conveyors . In their original design , conveyors traveled throughout the warehouse...lifts LCL lower confidence level xiv MRO material release order NPV net present value PMT positive material transfer POM Program Objective...depots. Active Radio Frequency Identification (aRFID ) Migration A program designed to move the active RFID enterprise from a proprietarily air interface

Operation HARDTACK. Project 2.13. Gamma Radiation and Induced Activity from Very-Low-Yield Bursts

DTIC Science & Technology

1983-10-01

of the Air Force Special Weapons Center; Clarence Slover of the Lexington Signal Depot, who processed the LSD film dosimeters; and Fred Rlggln of...indicated by an increase in fluorescence upon illumi- nation by ultraviolet light. The glass needles were air mailed to Brooklyn Naval Shipyard im

30. Oakland Port and General Depot. Transit Shed No. 7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 161 PLOT PLAN & TRANSVERSE SECTION. Sheet 1 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

34. Oakland Port and General Depot. Transit Shed No. 7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 70'0' TRUSS. Sheet 7 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

32. Oakland Port and General Depot. Transit Shed No. 7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 161 TYPICAL SECTION & DETAILS. Sheet 5 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

35. Oakland Port and General Depot. Transit Shed No. 7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 END WALL FRAMING. Sheet 9 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

33. Oakland Port and General Depot. Transit Shed No. 7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 STAIR & TOILET ROOM DETAILS. Sheet 6 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

31. Oakland Port and General Depot. Transit Shed No. 7, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Oakland Port and General Depot. Transit Shed No. 7, 936 feet, Building 127 STAIR & TOILET ROOM DETAILS. Sheet 3 of 16 - Oakland Army Base, Transit Shed, East of Dunkirk Street & South of Burma Road, Oakland, Alameda County, CA

Distribution depot over-ocean second-destination transportation costs

DOT National Transportation Integrated Search

1996-12-10

The issue of over-ocean second-destination transportation costs was identified during our work in the Distribution Depot business area of the Audit of Revenue accounts in the FY 1996 Financial Statements of the Defense Business Operations Fund (the R...

An Examination of the USAF (Q,R) Policies for Managing Depot-Base Inventories.

DTIC Science & Technology

1976-10-15

x OC. ½ EOQ J = [ ~- ~ ~~~ ___.1~ (A3) 0C~ = base j’s order processing cost = $5; tIC = unit acquisition cost of the given item...l - —— (C2) Uc x (11C0 + (llC~ - HCD) x j~~l (n~MDR~ /MDn 0)) where OC9 = depot order processing cost = $270.16; 0C~ = base order ... processing cost LIC unit acquisition cost of item; MCD = cost to hold caeh unit of the given item/yearat the depot , expressed as a fraction of its un i

Reviewing depot injection efficacy in the treatment of schizophrenia.

PubMed

Jones, Adrian; Jones, Martin

2016-04-13

Schizophrenia is a severe and enduring mental health disorder. Treatment includes antipsychotic medication and psychological interventions. Medication can be administered as a depot injection; these treatments reduce the risk of relapse in some people with schizophrenia who have difficulties adhering to oral medication regimens. This article outlines the types of depot and medications that are available for the treatment of schizophrenia, and discusses the evidence base supporting their efficacy. The role of antipsychotic medication as part of a treatment plan should be reinforced by enabling patients to make an informed choice about which medication best supports their health and wellbeing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clancey, P.; Logg, C.

DEPOT has been developed to provide tracking for the Stanford Linear Collider (SLC) control system equipment. For each piece of equipment entered into the database, complete location, service, maintenance, modification, certification, and radiation exposure histories can be maintained. To facilitate data entry accuracy, efficiency, and consistency, barcoding technology has been used extensively. DEPOT has been an important tool in improving the reliability of the microsystems controlling SLC. This document describes the components of the DEPOT database, the elements in the database records, and the use of the supporting programs for entering data, searching the database, and producing reports from themore » information.« less

2011 Munitions Executive Summit

DTIC Science & Technology

2011-02-04

Tooele Army Depot Tooele, UT ‐ Supply Depot Operations ‐ Ammunition Peculiar Equip Red River Munitions Center Texarkana , TX ‐ Supply Depot...0 1,000 2,000 3,000 4,000 5,000 6,000 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 6 September 2009 Platform President’s Meeting 2/9/2011...Interest & Discretionary ($B) – Table 1‐3 0 1,000 2,000 3,000 4,000 5,000 6,000 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Mandatory Defense

Current trend in drug delivery considerations for subcutaneous insulin depots to treat diabetes.

PubMed

P V, Jayakrishnapillai; Nair, Shantikumar V; Kamalasanan, Kaladhar

2017-05-01

Diabetes mellitus (DM) is a metabolic disorder due to irregularities in glucose metabolism, as a result of insulin disregulation. Chronic DM (Type 1) is treated by daily insulin injections by subcutaneous route. Daily injections cause serious patient non-compliance and medication non-adherence. Insulin Depots (ID) are parenteral formulations designed to release the insulin over a specified period of time, to control the plasma blood glucose level for intended duration. Physiologically, pancreas produces and secretes insulin in basal and pulsatile mode into the blood. Delivery systems mimicking basal release profiles are known as open-loop systems and current marketed products are open-loop systems. Future trend in open-loop systems is to reduce the number of injections per week by enhancing duration of action, by modifying the depot properties. The next generation technologies are closed-loop systems that mimic the pulsatile mode of delivery by pancreas. In closed-loop systems insulin will be released in response to plasma glucose. This review focuses on future trend in open-loop systems; by understanding (a) the secretion of insulin from pancreas, (b) the insulin regulation normal and in DM, (c) insulin depots and (d) the recent progress in open-loop depot technology particularly with respect to nanosystems. Copyright © 2017 Elsevier B.V. All rights reserved.

Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex.

PubMed

Mendonça, Anne M; Cayer, Lucien G J; Pauls, Samantha D; Winter, Tanja; Leng, Shan; Taylor, Carla G; Zahradka, Peter; Aukema, Harold M

2018-02-01

Dietary EPA and DHA given together alter oxylipins in adipose tissue. To compare the separate effects of individual dietary n-3 PUFA on oxylipins in different adipose depots (gonadal, mesenteric, perirenal, subcutaneous) in males and females, rats were provided diets containing higher levels of α-linolenic acid (ALA), EPA or DHA. Each n-3 PUFA enhanced its respective oxylipins the most, while effects on other n-3 oxylipins varied. For example: in perirenal and subcutaneous depots, more DHA oxylipins were higher with dietary ALA than with EPA; dietary EPA uniquely decreased 14-hydroxy-docosahexaenoic acid, in contrast to increasing many other DHA oxylipins. The n-3 PUFAs also reduced oxylipins from n-6 PUFAs in order of effectiveness: DHA > EPA > ALA. Diet by sex interactions in all depots except the perirenal depot resulted in higher oxylipins in males given DHA, and higher oxylipins in females given the other diets. Diet and sex effects on oxylipins did not necessarily reflect effects on either their tissue phospholipid or neutral lipid PUFA precursors. These varying diet and sex effects on oxylipins in the different adipose sites indicate that they may have distinct effects on adipose function. Copyright © 2017 Elsevier Ltd. All rights reserved.

Simulating Dissolution of Intravitreal Triamcinolone Acetonide Suspensions in an Anatomically Accurate Rabbit Eye Model

PubMed Central

Horner, Marc; Muralikrishnan, R.

2010-01-01

ABSTRACT Purpose A computational fluid dynamics (CFD) study examined the impact of particle size on dissolution rate and residence of intravitreal suspension depots of Triamcinolone Acetonide (TAC). Methods A model for the rabbit eye was constructed using insights from high-resolution NMR imaging studies (Sawada 2002). The current model was compared to other published simulations in its ability to predict clearance of various intravitreally injected materials. Suspension depots were constructed explicitly rendering individual particles in various configurations: 4 or 16 mg drug confined to a 100 μL spherical depot, or 4 mg exploded to fill the entire vitreous. Particle size was reduced systematically in each configuration. The convective diffusion/dissolution process was simulated using a multiphase model. Results Release rate became independent of particle diameter below a certain value. The size-independent limits occurred for particle diameters ranging from 77 to 428 μM depending upon the depot configuration. Residence time predicted for the spherical depots in the size-independent limit was comparable to that observed in vivo. Conclusions Since the size-independent limit was several-fold greater than the particle size of commercially available pharmaceutical TAC suspensions, differences in particle size amongst such products are predicted to be immaterial to their duration or performance. PMID:20467888

Tests of the higher order turbulence model for atmospheric circulations (HOTMAC) at Deseret Chemical Depot

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costigan, K.R.

1998-11-01

Deseret Chemical Depot is one of the US Army`s storage facilities for its stockpile of chemical weapon agents. Congress has directed the Department of Defense to eliminate the aging stockpiles, which have existed since the end of World War II, and the US Army is destroying these lethal chemical munitions. Although the danger is slight, accurate predictions of the wind field in the valley are necessary for dispersion calculations in the event of an accident involving toxic chemicals at the depot. There are several small communities in Rush and Tooele valleys, including the town of Tooele, and Salt Lake Citymore » is located 65 km to the Northeast of Deseret Chemical Depot South area, at 1,300 m MSL and beyond the Oquirrh Mountains. The purpose of this report is to carry out three-dimensional numerical simulations of the atmospheric circulations in the region around Deseret Chemical Depot with the Higher Order Turbulence Model for Atmospheric Circulations (HOTMAC) and to evaluate the performance of the model. The code had been modified to assimilate local meteorological observations through the use of Newtonian nudging. The nudging scheme takes advantage of the extensive network of local observations in the valley.« less

Hood River Production Master Plan.

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Toole, Patty

1991-07-01

The Northwest Power Planning Council's 1987 Columbia River Fish and Wildlife Program authorizes the development of artificial production facilities to raise chinook salmon and steelhead for enhancement in the Hood, Umatilla, Walla Walla, Grande Ronde and Imnaha rivers and elsewhere. On February 26, 1991 the Council agreed to disaggregate Hood River from the Northeast Oregon Hatchery Project, and instead, link the Hood River Master Plan (now the Hood River Production Plan) to the Pelton Ladder Project (Pelton Ladder Master Plan 1991).

Supplement Analysis for the Watershed Management Program EIS (DOE/EIS-0265/SA-66)

DOE Office of Scientific and Technical Information (OSTI.GOV)

N /A

2001-10-04

BPA proposes to fund four projects that will enhance instream flow in several subbasins throughout Oregon. The Oregon Water Trust acquires existing water rights on a voluntary basis through purchase, gift and water conservation projects, and converts the rights to instream flow under Oregon state water law. The proposed projects are all related to an on-going program of water rights acquisition in the Columbia Plateau Basin (Deschutes, John Day, Umatilla and Walla Walla subbasins) and the Columbia Gorge Basin (Fifteenmile subbasin) by the Oregon Water Trust (OWT). The current funding cycle extends through fiscal year 2001. Additional funding is currentlymore » being sought for fiscal years 2002-2004. Specific acquisition transactions are evaluated throughout the duration of the project, so on-the-ground impacts may only be estimated. The proposed project is an extension of previous water rights acquisition projects within the subject subbasins, dating back to 1994. The objective of the proposed projects in the next cycle, 2002 through 2004, is to acquire a total of approximately 12.6 cfs on tributary streams within the subbasins. The target level of water rights acquired, by subbasin, are as follows: Deschutes subbasin--2.0 cfs; Fifteenmile subbasin--1.4 cfs; John Day subbasin--2.0 cfs; Umatilla subbasin--1.0 cfs; Walla Walla subbasin--4.2 cfs; and newly prioritized streams within the region--2.0 cfs.« less

NeuronDepot: keeping your colleagues in sync by combining modern cloud storage services, the local file system, and simple web applications

PubMed Central

Rautenberg, Philipp L.; Kumaraswamy, Ajayrama; Tejero-Cantero, Alvaro; Doblander, Christoph; Norouzian, Mohammad R.; Kai, Kazuki; Jacobsen, Hans-Arno; Ai, Hiroyuki; Wachtler, Thomas; Ikeno, Hidetoshi

2014-01-01

Neuroscience today deals with a “data deluge” derived from the availability of high-throughput sensors of brain structure and brain activity, and increased computational resources for detailed simulations with complex output. We report here (1) a novel approach to data sharing between collaborating scientists that brings together file system tools and cloud technologies, (2) a service implementing this approach, called NeuronDepot, and (3) an example application of the service to a complex use case in the neurosciences. The main drivers for our approach are to facilitate collaborations with a transparent, automated data flow that shields scientists from having to learn new tools or data structuring paradigms. Using NeuronDepot is simple: one-time data assignment from the originator and cloud based syncing—thus making experimental and modeling data available across the collaboration with minimum overhead. Since data sharing is cloud based, our approach opens up the possibility of using new software developments and hardware scalabitliy which are associated with elastic cloud computing. We provide an implementation that relies on existing synchronization services and is usable from all devices via a reactive web interface. We are motivating our solution by solving the practical problems of the GinJang project, a collaboration of three universities across eight time zones with a complex workflow encompassing data from electrophysiological recordings, imaging, morphological reconstructions, and simulations. PMID:24971059

NeuronDepot: keeping your colleagues in sync by combining modern cloud storage services, the local file system, and simple web applications.

PubMed

Rautenberg, Philipp L; Kumaraswamy, Ajayrama; Tejero-Cantero, Alvaro; Doblander, Christoph; Norouzian, Mohammad R; Kai, Kazuki; Jacobsen, Hans-Arno; Ai, Hiroyuki; Wachtler, Thomas; Ikeno, Hidetoshi

2014-01-01

Neuroscience today deals with a "data deluge" derived from the availability of high-throughput sensors of brain structure and brain activity, and increased computational resources for detailed simulations with complex output. We report here (1) a novel approach to data sharing between collaborating scientists that brings together file system tools and cloud technologies, (2) a service implementing this approach, called NeuronDepot, and (3) an example application of the service to a complex use case in the neurosciences. The main drivers for our approach are to facilitate collaborations with a transparent, automated data flow that shields scientists from having to learn new tools or data structuring paradigms. Using NeuronDepot is simple: one-time data assignment from the originator and cloud based syncing-thus making experimental and modeling data available across the collaboration with minimum overhead. Since data sharing is cloud based, our approach opens up the possibility of using new software developments and hardware scalabitliy which are associated with elastic cloud computing. We provide an implementation that relies on existing synchronization services and is usable from all devices via a reactive web interface. We are motivating our solution by solving the practical problems of the GinJang project, a collaboration of three universities across eight time zones with a complex workflow encompassing data from electrophysiological recordings, imaging, morphological reconstructions, and simulations.

Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity

PubMed Central

Farb, Melissa G.; Tiwari, Stephanie; Karki, Shakun; Ngo, Doan TM; Carmine, Brian; Hess, Donald T.; Zuriaga, Maria A.; Walsh, Kenneth; Fetterman, Jessica L.; Hamburg, Naomi M.; Vita, Joseph A.; Apovian, Caroline M.; Gokce, Noyan

2013-01-01

Objective The purpose of this study was to determine whether cyclooxygenase inhibition improves vascular dysfunction of adipose microvessels from obese humans. Design and Methods In 20 obese subjects (age 37±12 yrs, BMI 47±8 kg/m2) we collected subcutaneous and visceral fat during bariatric surgery and characterized adipose depot-specific gene expression, endothelial cell phenotype, and microvascular function. Vasomotor function was assessed in response to endothelium-dependent agonists using videomicroscopy of small arterioles from fat. Results Arterioles from visceral fat exhibited impaired endothelium-dependent, acetylcholine-mediated vasodilation, compared to the subcutaneous depot (p<0.001). Expression of mRNA transcripts relevant to the cyclooxygenase pathway were upregulated in visceral compared to subcutaneous fat. Pharmacological inhibition of cyclooxygenase with indomethacin improved endothelium-dependent vasodilator function of arterioles from visceral fat by 2-fold (p=0.01), whereas indomethacin had no effect in the subcutaneous depot. Indomethacin increased activation via serine-1177 phosphorylation of endothelial nitric oxide synthase in response to acetylcholine in endothelial cells from visceral fat. Inhibition of endothelial nitric oxide synthase with Nω-nitro-L-arginine methyl ester abrogated the effects of cyclooxygenase-inhibition suggesting that vascular actions of indomethacin were related to increased nitric oxide bioavailability. Conclusions Our findings suggest that cyclooxygenase-mediated vasoconstrictor prostanoids partly contribute to endothelial dysfunction of visceral adipose arterioles in human obesity. PMID:23640904

Reducing needlestick injuries: a review of a community service.

PubMed

Aziz, Ann-Marie

Community nurses provide care to patients in a variety of settings; for example, health centres, community hospitals, patients' homes, and residential and nursing homes. Administering intramuscular (IM)injections to patients in the community is an everyday activity for many nurses in clinical practice. A great deal of problems related to being 'sharps safe' are common to both community nurses and hospital staff. There had been a reported six needlestick injuries (NSIs) from community clinics administering depot IM injections, which required a review. An audit of practice was undertaken in clinics administering depot injections. The audit was undertaken to monitor compliance in sharps management and investigated how community nurses were administering IM injections. The review highlighted a lack of resources, gaps in knowledge and training deficits. The infection prevention and control nurses worked hard to improve practices and procedures. After a year, there had been a significant reduction in NSIs.

Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty

ClinicalTrials.gov

2014-01-08

Precocious; Leuprolide Acetate; Luteinizing Hormone (LH); Gonadotrophin-releasing Hormone Agonist (GnRHa); Tanner Staging; Depot Formulation; Suppression of LH; Central Precocious Puberty (CPP); Gonadotrophin-releasing Hormone (GnRH); Lupron; GnRH Analog; Pediatrics Central Precocious Puberty

Analysis of Tobyhanna Army Depot’s Radio Frequency Identification (RFID) Pilot Program: RFID as an Asset Management Tool

DTIC Science & Technology

2005-06-01

each has advantages and disadvantages. 1. Active Tags The main difference between the two types of RFID tags is that active tags have an internal...battery source and passive tags do not. The advantage of the active tag is that it transmits its own signal, which increases the read range of the...applications provide a stand-alone solution that employs a specific usage application of RFID and has clear economic advantages over supply chain

An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice.

PubMed

Wijayatunga, Nadeeja N; Pahlavani, Mandana; Kalupahana, Nishan S; Kottapalli, Kameswara Rao; Gunaratne, Preethi H; Coarfa, Cristian; Ramalingam, Latha; Moustaid-Moussa, Naima

2018-02-06

Obesity contributes to metabolic disorders such as diabetes and cardiovascular disease. Characterization of differences between the main adipose tissue depots, white (WAT) [including subcutaneous (SAT) and visceral adipose tissue (VAT)] and brown adipose tissue (BAT) helps to identify their roles in obesity. Thus, we studied depot-specific differences in whole transcriptome and miRNA profiles of SAT, VAT and BAT from high fat diet (HFD/45% of calories from fat) fed mice using RNA sequencing and small RNA-Seq. Using quantitative real-time polymerase chain reaction, we validated depot-specific differences in endoplasmic reticulum (ER) stress related genes and miRNAs using mice fed a HFD vs. low fat diet (LFD/10% of calories from fat). According to the transcriptomic analysis, lipogenesis, adipogenesis, inflammation, endoplasmic reticulum (ER) stress and unfolded protein response (UPR) were higher in VAT compared to BAT, whereas energy expenditure, fatty acid oxidation and oxidative phosphorylation were higher in BAT than in VAT of the HFD fed mice. In contrast to BAT, ER stress marker genes were significantly upregulated in VAT of HFD fed mice than the LFD fed mice. For the first time, we report depot specific differences in ER stress related miRNAs including; downregulation of miR-125b-5p, upregulation miR-143-3p, and miR-222-3p in VAT following HFD and upregulation of miR-30c-2-3p only in BAT following a HFD in mice than the LFD mice. In conclusion, HFD differentially regulates miRNAs and genes in different adipose depots with significant induction of genes related to lipogenesis, adipogenesis, inflammation, ER stress, and UPR in WAT compared to BAT.

[Effect of angiotensin II depot administration on bioelectric functional processes of the central nervous system].

PubMed

Martin, G; Baumann, H; Grieger, F

1976-01-01

Using the average evoked potential technique, angiotensin-II depot effects (1 mg implantate = 3--4 mg/kg body weight angiotensin-II) were studied neuroelectrophysiologically in reticular, hippocampal and neocrotical structures of albino rats. A multivariate variance and discriminance analysis program revealed differentiated changes of the bioelectrical processing data of the CNS. Evidence was obtained for a varying structural sensitivity of central-nervous substructures under depot administration of angiotensin-II. In later phases of angiotensin-II action, the hippocampus was characterized by an electrographic synchronization phenomenon with high-amplitude average evoked potentials. The reticular formation, and to a lesser extent the visual cortex, showed an angiotensin-induced diminution of bioelectrical excitation. However, the intensity of the change in functional CNS patterns did not always correlate with maximal blood pressure rises. The described changes of afference processing to standardized sensory stimuli, especially in hippocampal and reticular structures of the CNS foll owing angiotensin depot action, point to a central-nervous action mechanism of angiotensin-II.

Humans and Mice Display Opposing Patterns of "Browning" Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots.

PubMed

Zuriaga, Maria A; Fuster, Jose J; Gokce, Noyan; Walsh, Kenneth

2017-01-01

Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology.

Population modelling to describe pharmacokinetics of amiodarone in rats: relevance of plasma protein and tissue depot binding.

PubMed

Campos Moreno, Eduardo; Merino Sanjuán, Matilde; Merino, Virginia; Nácher, Amparo; Martín Algarra, Rafael V; Casabó, Vicente G

2007-02-01

The objective of this paper was to characterize the disposition phase of AM in rats, after different high doses and modalities of i.v. administration. Three fitting programs, WINNONLIN, ADAPT II and NONMEM were employed. The two-stage fitting methods led to different results, none of which can adequately explain amiodarone's behaviour, although a great amount of data per subject is available. The non-linear mixed effect modelling approach allows satisfactory estimation of population pharmacokinetic parameters, and their respective variability. The best model to define the AM pharmacokinetic profile is a two-compartment model, with saturable and dynamic plasma protein binding and linear tissular depot dynamic binding. These results indicate that peripheral tissues act as depots, causing an important fall in AM plasma levels in the first moment after dosing. Later, the return of the drug from these depots causes a slow increase in serum concentration whenever the dose is reduced.

[Biological function of trophology and the pathogenesis of metabolic syndrome--syndrome of overeating. Phylogenetically theory of general pathology, role of leptin and adiponectin].

PubMed

Titov, V N

2014-01-01

Metabolic syndrome (overeating) is a phylogenetically-determined succession of symptoms with the same pathogenesis. There is only one etiological factor, namely, increased consumption of physiologically optimal food. Enterocytes and omental fat cells are a phylogenetically early paracrine-regulated cell community that realizes the biological reactions of exo- and endotrophy. Visceral obesity, high levels of unesterified fatty acids (FA), formation of a pool of micellar FA in the blood, integration of these FA into endothelial cell plasma membrane and enlargement of adipocytes are the causes of hydrodynamic pressure elevation. Toll-like receptors recognize the associates between albumin and greater than physiological number of FA as "foreing" and initiate inflammatory response. "Endoplasm stress" develops in lipid-overloaded cells, protein synthesis (folding) in them is impaired and apoptosis-like cell death is activated. Visceral fat is a phylogenetically early depot of FA to fulfill the biological function of homeostasis, trophology, endoecology and adaptation; it is regulated at the level of paracrine communities and is anatomically limited. The subcutaneous fat depot fulfills the phylogenetically late function of locomotion; the depot size is not anatomically limited. Visceral fat cells have no receptors for phylogenetically late insulin (INS); specialized adipocyes bearing INS and GLUT4 receptors are cells that form the subcutaneous depot. These cells are regulated by phylogenetically late humoral factors at the entire body level. Leptin is an initiator of humoral hypothalamic regulation of in vivo number of ontogenetically programmed number of visceral INS-insensitive fat cells. It prevents "endoplasm stress" and apoptosis, being designed to regulate the amount of consumed food. Leptin initiates storage of FA from visceral pool into subcutaneous pool. Adiponectin is a phylogenetically late humoral hypothalamic regulatory factor that controls optimal number of fat cells in vivo. Its biological role consists in regulation of the number (proliferation) of insulin-dependent adipocytes in subcutaneous fatty tissue.

American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robert P. Breckenridge; Thomas R. Wood

2010-08-01

The purpose of this document is to evaluate the opportunity for Letterkenny Army Depot (LEAD or the Depot) to utilize biogenic methane, which may be available in shale formations under the Depot, to provide a supplemental source of natural gas that could allow the Depot to increase energy independence. Both the Director and Deputy of Public Works at the Depot are supportive in general of a methane production project, but wanted to better understand the challenges prior to embarking on such a project. This report will cover many of these issues. A similar project has been successfully developed by themore » U. S. Army at Ft. Knox, KY, which will be explained and referred to throughout this report as a backdrop to discussing the challenges and opportunities at LEAD, because the geologic formations and possibilities at both sites are similar. Prior to discussing the opportunity at LEAD, it is important to briefly discuss the successful methane recovery operation at Ft. Knox, because it is applicable to the projected approach for the LEAD methane system. The Ft. Knox project is an excellent example of how the U. S. Army can use an onsite renewable resource to provide a secure energy source that is not dependent on regional energy networks and foreign oil. At Ft. Knox, the U. S. Army contracted (through a utility co-op) with an energy production company to drill wells, establish a distribution infrastructure, and provide the equipment needed to prepare and compress the produced methane gas for use by base operations. The energy production company agreed to conduct the exploratory investigation at Ft. Knox with no cost to the government, as long as they could be granted a long-term contract if a reliable energy resource was established. The Depot is located, in part, over an Ordovician Age shale formation that may have the potential for producing biogenic methane, similar to the Devonian Age shale found beneath Ft. Knox. However, the Ordovician Age Shale beneath the Letterkenny Depot is not known to have any currently producing gas wells.« less

[Nitrous oxide production by the German Armed Forces in the 20th century : History of medicine and pharmacy in the Armed Forces].

PubMed

Kronabel, D B J

2010-03-01

The nitrous oxide production unit of the German Armed Forces was a worldwide unique facility which was only employed in the former main medical depot at Euskirchen (nitrous oxide: medical gas which is now obsolete). The last unit was phased out in 2002 and brought to the main medical depot at Blankenburg. Unfortunately the unit is now no longer in the depot and seems to have disappeared. This article describes the nitrous oxide production process and the use of the production unit which was designed by the Socsil company of Switzerland.

Documentation and Evaluation of Depot Maintenance Cost Accumulation and Reporting at the Naval Air Rework Facility, Jacksonville, Florida.

DTIC Science & Technology

1984-06-01

Barilla , 1984). B. NARF JACKSONVILLE 1. Activities and Services NARF Jacksonville is one of the six industrially funded maintenance facilities which...MC =arine Corps N =Navy DSA z Defense Security Assistance OFA - Other Federal Agencies NFA a Non-Federal Agencies 80 1" 6 LIST OF REFERENCES Barilla

Environmentally Friendly Zirconium Oxide Pretreatment

DTIC Science & Technology

2013-05-01

during the conversion of the highly soluble hexavalent chromate ions to an inert and relatively insoluble trivalent chromium oxide layer. Depletion of...are being used commercially in automotive and other industrial operations as replacements to hexavalent chromium -based and zinc phosphate...Society for Testing and Materials AVCRAD Aviation Classification Repair Activity Depot Chrome (VI) Hexavalent Chromium CRS Cold Rolled Steel

Depot Maintenance Transformation: Successful Strategies in Capital Investing

DTIC Science & Technology

2010-06-01

parking areas, increased property, sales and wage taxes from higher economic activity downtown, etc. Societal Benefits: Reduced unemployment ...raw materials and wages ) and fixed-capital (factories and machinery) which quickly identifies the DMT projects as fixed-capital investments since...and establishes the necessary international coordination to provide a seamless global aviation system. (FAA, 2010) According to its 2003-2007

Demonstration of Military Composites With Low Hazardous Air Pollutant Content

DTIC Science & Technology

2007-07-01

84506 § Naval Surface Warfare Center Carderock, West Bethesda, MD 20817 **Red River Army Depot, U.S. Army TACOM, Texarkana , TX 75507-5000 14...Depot, US Army TACOM Texarkana , TX 75507-5000 * To whom all correspondence should be addressed ABSTRACT Liquid resins used for molding

Stromal vascular cells and adipogenesis: Cells within adipose depots regulate adipogenesis

USDA-ARS?s Scientific Manuscript database

A collection of investigations indicate the importance of adipose tissue stromal/stem cells to vasculogenesis and angiogenesis during adipogenesis. Early in development the stromal-vascular (S-V) elements control and dictate the extent of adipogenesis in a depot dependent manner. For instance, the...

Secondary Item Repair of Depot Reparables.

DTIC Science & Technology

1980-11-01

34- , Because of the length of support pipelines, advance planning is necessary to provide adequate support. • T The primary mission of depot repair is...pass a narrativr card to DESCOM Indicating the l i.tlty not inducted and reasons why. 2. Fuction t Rec iremen ts BTK/BTG cards received from DESCOM

Guidelines for Managing Vegetation on Earth-Covered Magazines Within the U.S. Army Materiel Command

DTIC Science & Technology

1994-05-01

Plant Basil Kirby, Pest Controller, Letterkenny Army Depot Ken Davis, Safety Office, Depot Systt., Command Robert Klein, Army Materiel Command Field...refertilization, herbicides, tion techniques; this should be done by visiting the plant growth regulators, pesticides , mowing or site, talking to the

78 FR 77108 - Surplus Property Notice at a Military Installation Designated for Disposal: Pueblo Chemical Depot...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... DEPARTMENT OF DEFENSE Department of the Army Surplus Property Notice at a Military Installation Designated for Disposal: Pueblo Chemical Depot, Colorado AGENCY: Department of the Army, DoD. ACTION: Notice..., as approved, and following screening with Federal agencies and Department of Defense components...

A Conceptual Framework for the U.S. Army Tactical Wheeled Vehicle Optimization Model

DTIC Science & Technology

2007-06-01

Texarkana , TX SDVF Single-Dimensional Value Function TACOM Tank-Automotive and Armaments Command (US Army) TOW Tube-launched, Optically-tracked, Wire...armor add-on. This recapping process takes place at Letterkenny Army Depot, Chambersburg, PA (LEAD), and Red River Army Depot, Texarkana , TX (RRAD

Demonstration of Tar Removal from Paving Equipment and Ground Vehicles

DTIC Science & Technology

2011-05-12

IL 61822 Suresh Naik and Michael Starks, Red River Army Depot, Texarkana , TX Pam Khabra, TACOM/TARDEC, Warren, MI Malcolm E. McLeod, US Army...maintenance facilities of the Red River Army Depot (RRAD), Texarkana , TX. OBJECTIVE BUILDING STRONG®7 APPROACH 1. Develop criteria to rank commercial

Identification of a new supraclavicular brown fat depot in mice

USDA-ARS?s Scientific Manuscript database

The rediscovery of brown adipose tissue (BAT) in healthy adult humans raises the possibility of utilizing BAT to combat obesity and its related metabolic disorders. Adult humans possess limited amounts of BAT with the most thermoactive depot located in the supraclavicular area of the neck. Understan...

Environmental Assessment KC-46A Depot Maintenance Activation, Tinker Air Force Base, Oklahoma. Volume 1

DTIC Science & Technology

2014-03-01

difficulty in obtaining replacement parts, the Ai r Force has challenges in maintaining tbe KC-135 fleet (USAF 2005). Additionally this fleet has been...aircraft fleet wi ll remain within the Ai r Force inventory. Therefore, only the BNSF Rail Yard and DLA Infill were carried forward for further...surface water from C&D activities. In addition, existing Tinker AFB National Pollutant Discharge Elimination System permit, general permits (multi- sector

How Much Will Be Enough? Assessing Changing Defense Strategies Implications for Army Resource Requirements

DTIC Science & Technology

2014-01-01

reaching a peak of $212M (constant 2010 dollars) over the baseline language program in 2010. Needless to say, neither this increase nor the increase...committed on a large scale, as has occurred with Afghanistan and Iraq. This figure assumes peaks and valleys in requirements as wars begin and wind...Support • SRM • Depot Maintenance • Reset • Service-Wide Transportation • Central Supply Activities • Logistic Support Activities • Ammunition

[Preauricular injection of betamethasone depot and acyclovir for the treatment of acute herpes zoster ophthalmicus].

PubMed

Arenas-Archila, E; Alvizu, F; Muñoz-Sarmiento, D

2015-04-01

Several treatments have been described for the management of patients with herpes zoster ophthalmicus (HZO). However, the progress of these patients is usually slow, and many of them develop postherpetic neuritis (PHN). In the present paper, three clinical cases are presented, in which a significant symptomatic improvement was obtained by using a preauricular injection of a mixture of betamethasone depot combined with acyclovir. PHN did not develop in any of them. The preauricular injection of betamethasone depot and acyclovir could be a good alternative for the management of HZO. Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

Orbiting propellent depot safety. Volume 2: Technical discussion

NASA Technical Reports Server (NTRS)

1971-01-01

The results of a study assessing the gross requirements and concomitant safety hazards associated with the operation of several configurations of orbiting propellant depots (OPD) are presented. The major structural and operational aspects of the integral, semimodular, and modular concepts are described. The concepts are evaluated to determine their safety hazards, and emphasis is placed on propellant transfer to and from the OPD. The study indicates that a modular mode of depot resupply is desirable regardless of the OPD configuration. This resupply mode requires no flow transfer to resupply either the semimodular or modular OPD. Of the three concepts, the semimodular appears to provide the best operational advantage and lowest safety risk.

Analysis of the relationship between the decrease in pH and accumulation of 3-phosphoglyceric acid in developing forespores of Bacillus species.

PubMed

Magill, N G; Cowan, A E; Leyva-Vazquez, M A; Brown, M; Koppel, D E; Setlow, P

1996-04-01

Analysis of the pH decrease and 3-phosphoglyceric acid (3PGA) accumulation in the forespore compartment of sporulating cells of Bacillus subtilis showed that the pH decrease of 1 to 1.2 units at approximately 4 h of sporulation preceded 3PGA accumulation, as observed previously in B. megaterium. These data, as well as analysis of the forespore pH decrease in asporogenous mutants of B. subtilis, indicated that sigma G-dependent forespore transcription, but not sigma K-dependent mother cell transcription, is required for the forespore pH decrease. Further analysis of these asporogenous mutants showed an excellent correlation between the forespore pH decrease and the forespore's accumulation of 3PGA. These latter results are consistent with our previous suggestion that the decrease in forespore pH results in greatly decreased activity of phosphoglycerate mutase in the forespore, which in turn leads to 3PGA accumulation. In further support of this suggestion, we found that (i) elevating the pH of developing forespores of B. megaterium resulted in rapid utilization of the forespore's 3PGA depot and (ii) increasing forespore levels of PGM approximately 10-fold in B. subtilis resulted in a large decrease in the spore's depot of 3PGA. The B. subtilis strain with a high phosphoglycerate mutase level sporulated, and the spores germinated and went through outgrowth normally, indicating that forespore accumulation of a large 3PGA depot is not essential for these processes.

Development of Intra-Articular Drug Delivery to Alter Progression of Arthritis Following Joint Injury

DTIC Science & Technology

2013-04-01

sTNFRII in combination. The treatments were encapsulated in elastin -like polypeptide (ELP) drug depots that have been associated with a 25-fold...or both IL-1Ra and sTNFRII. The drugs were encapsulated in elastin -like polypeptide (ELP) drug depots that slowly disaggregate for prolonged IA

78 FR 25258 - Notice of Availability (NOA) for Sharpe Permit Relinquishment Project Environmental Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

..., California 95440 and at the Defense Distribution Depot San Joaquin--Tracy Site Public Affairs Office, 2600 S... Distribution Depot San Joaquin--Tracy Site Public Affairs Office at (209) 839-4226. ADDRESSES: You may submit..., VA 22350- 3100. FOR FURTHER INFORMATION CONTACT: Public Affairs Office, Tracy, California, (209) 839...

A Standardization Evaluation Potential Study of the Common Multi-Mode Radar Program.

DTIC Science & Technology

1979-11-01

Radar, the RX (RF-16 etc.), Enhanced Tactical Fighter ( ETF ), and A-7. Candidate radar systems applicable to the Common Multi-Mode Radar Program...RSTC R Resupply Time to Overseas Located Bases (hours) RSTO R Depot Stock Safety Factor (standard deviations) DLY R Shipping Time to Depot from CONUS

U.S. Navy Shipyards. An Evaluation of Workload- and Workforce-Management Practices

DTIC Science & Technology

2008-01-01

7 million man-hours (875,000 man-days). 2 Note that the Bradley Fighting Vehicle is maintained by the Red River Army Depot in Texarkana , Texas...and Workforce-Management Practices 103 The Red River Army Depot in Texarkana , Texas, supports the Bradley Fighting Vehicle as well as the Multiple

Novel depots of buprenorphine have a long-acting effect for the management of physical dependence to morphine.

PubMed

Liu, Kuo-Sheng; Kao, Cheng-Hsiung; Liu, Shyun-Yeu; Sung, K C; Kuei, Chun-Hsiung; Wang, Jhi-Joung

2006-03-01

Buprenorphine is a promising new pharmacotherapy for the management of physical dependence to opioids. The aim of the study was to evaluate the duration of action of several novel depots of buprenorphine in the treatment of physical dependence to morphine in mice. Following intramuscular injection, the duration of action of several novel oil-based depots of buprenorphine base in morphine-dependent mice were evaluated. The traditional dosage form of buprenorphine hydrochloride in saline was used as control. We found that the depot of buprenorphine base in sesame oil produced a dose-related long-lasting effect. On an equimolar basis of 6 micromol kg(-1), its effect was 5.7-fold longer than that of buprenorphine hydrochloride in saline. When prepared in several other oleaginous vehicles (castor oil, cottonseed oil, peanut oil and soybean oil), buprenorphine base also produced a long-lasting effect, which was similar to buprenorphine base in sesame oil. In conclusion, buprenorphine base, when prepared in oleaginous vehicles and injected intramuscularly in mice, produced a long-lasting effect on physical dependence to morphine.

An Archeological Overview and Management Plan for the Savanna Army Depot Activity, Jo Davies and Carroll Counties, Illinois.

DTIC Science & Technology

1984-05-07

lack of available plant nutrients (Curtis 1959:311). These areas support relict plant and animals more typical of the sand hills of Nebraska and Kansas...0 .0 C C2-12 0202D-5 Economic pursuits included hunting of Pleistocene megafauna ; however, use of smaller game animals and gathering of wild plant

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

PubMed

Cypess, Aaron M; White, Andrew P; Vernochet, Cecile; Schulz, Tim J; Xue, Ruidan; Sass, Christina A; Huang, Tian Liang; Roberts-Toler, Carla; Weiner, Lauren S; Sze, Cathy; Chacko, Aron T; Deschamps, Laura N; Herder, Lindsay M; Truchan, Nathan; Glasgow, Allison L; Holman, Ashley R; Gavrila, Alina; Hasselgren, Per-Olof; Mori, Marcelo A; Molla, Michael; Tseng, Yu-Hua

2013-05-01

The imbalance between energy intake and expenditure is the underlying cause of the current obesity and diabetes pandemics. Central to these pathologies is the fat depot: white adipose tissue (WAT) stores excess calories, and brown adipose tissue (BAT) consumes fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1). BAT was once thought to have a functional role in rodents and human infants only, but it has been recently shown that in response to mild cold exposure, adult human BAT consumes more glucose per gram than any other tissue. In addition to this nonshivering thermogenesis, human BAT may also combat weight gain by becoming more active in the setting of increased whole-body energy intake. This phenomenon of BAT-mediated diet-induced thermogenesis has been observed in rodents and suggests that activation of human BAT could be used as a safe treatment for obesity and metabolic dysregulation. In this study, we isolated anatomically defined neck fat from adult human volunteers and compared its gene expression, differentiation capacity and basal oxygen consumption to different mouse adipose depots. Although the properties of human neck fat vary substantially between individuals, some human samples share many similarities with classical, also called constitutive, rodent BAT.

Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids.

PubMed

McQuaid, Siobhán E; Humphreys, Sandy M; Hodson, Leanne; Fielding, Barbara A; Karpe, Fredrik; Frayn, Keith N

2010-10-01

Gluteo-femoral, in contrast to abdominal, fat accumulation appears protective against diabetes and cardiovascular disease. Our objective was to test the hypothesis that this reflects differences in the ability of the two depots to sequester fatty acids, with gluteo-femoral fat acting as a longer-term "sink." A total of 12 healthy volunteers were studied after an overnight fast and after ingestion of a mixed meal. Blood samples were taken from veins draining subcutaneous femoral and abdominal fat and compared with arterialized blood samples. Stable isotope-labeled fatty acids were used to trace specific lipid fractions. In 36 subjects, adipose tissue blood flow in the two depots was monitored with (133)Xe. Blood flow increased in response to the meal in both depots, and these responses were correlated (r(s) = 0.44, P < 0.01). Nonesterified fatty acid (NEFA) release was suppressed after the meal in both depots; it was lower in femoral fat than in abdominal fat (P < 0.01). Plasma triacylglycerol (TG) extraction by femoral fat was also lower than that by abdominal fat (P = 0.05). Isotopic tracers showed that the difference was in chylomicron-TG extraction. VLDL-TG extraction and direct NEFA uptake were similar in the two depots. Femoral fat shows lower metabolic fluxes than subcutaneous abdominal fat, but differs in its relative preference for extracting fatty acids directly from the plasma NEFA and VLDL-TG pools compared with chylomicron-TG.

Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids

PubMed Central

McQuaid, Siobhán E.; Humphreys, Sandy M.; Hodson, Leanne; Fielding, Barbara A.; Karpe, Fredrik; Frayn, Keith N.

2010-01-01

OBJECTIVE Gluteo-femoral, in contrast to abdominal, fat accumulation appears protective against diabetes and cardiovascular disease. Our objective was to test the hypothesis that this reflects differences in the ability of the two depots to sequester fatty acids, with gluteo-femoral fat acting as a longer-term “sink.” RESEARCH DESIGN AND METHODS A total of 12 healthy volunteers were studied after an overnight fast and after ingestion of a mixed meal. Blood samples were taken from veins draining subcutaneous femoral and abdominal fat and compared with arterialized blood samples. Stable isotope-labeled fatty acids were used to trace specific lipid fractions. In 36 subjects, adipose tissue blood flow in the two depots was monitored with 133Xe. RESULTS Blood flow increased in response to the meal in both depots, and these responses were correlated (rs = 0.44, P < 0.01). Nonesterified fatty acid (NEFA) release was suppressed after the meal in both depots; it was lower in femoral fat than in abdominal fat (P < 0.01). Plasma triacylglycerol (TG) extraction by femoral fat was also lower than that by abdominal fat (P = 0.05). Isotopic tracers showed that the difference was in chylomicron-TG extraction. VLDL-TG extraction and direct NEFA uptake were similar in the two depots. CONCLUSIONS Femoral fat shows lower metabolic fluxes than subcutaneous abdominal fat, but differs in its relative preference for extracting fatty acids directly from the plasma NEFA and VLDL-TG pools compared with chylomicron-TG. PMID:20682685

Sustained release of antibiotics from injectable and thermally responsive polypeptide depots.

PubMed

Adams, Samuel B; Shamji, Mohammed F; Nettles, Dana L; Hwang, Priscilla; Setton, Lori A

2009-07-01

Biodegradable polymeric scaffolds are of interest for delivering antibiotics to local sites of infection in orthopaedic applications, such as bone and diarthrodial joints. The objective of this study was to develop a biodegradable scaffold with ease of drug loading in aqueous solution, while providing for drug depot delivery via syringe injection. Elastin-like polypeptides (ELPs) were used for this application, biopolymers of repeating pentapeptide sequences that were thermally triggered to undergo in situ depot formation at body temperature. ELPs were modified to enable loading with the antibiotics, cefazolin, and vancomycin, followed by induction of the phase transition in vitro. Cefazolin and vancomycin concentrations were monitored, as well as bioactivity of the released antibiotics, to test an ability of the ELP depot to provide for prolonged release of bioactive drugs. Further tests of formulation viscosity were conducted to test suitability as an injectable drug carrier. Results demonstrate sustained release of therapeutic concentrations of bioactive antibiotics by the ELP, with first-order time constants for drug release of approximately 25 h for cefazolin and approximately 500 h for vancomycin. These findings illustrate that an injectable, in situ forming ELP depot can provide for sustained release of antibiotics with an effect that varies across antibiotic formulation. ELPs have important advantages for drug delivery, as they are known to be biocompatible, biodegradable, and elicit no known immune response. These benefits suggest distinct advantages over currently used carriers for antibiotic drug delivery in orthopedic applications. (c) 2008 Wiley Periodicals, Inc.

The fatty acid profile of fat depots from Santa Inês sheep fed spineless cactus (Opuntia ficus-indica Mill.).

PubMed

Costa, Roberto G; Almeida, Michelly DA; Cruz, George Rodrigo B; Beltrão Filho, Edvaldo M; Ribeiro, Neila L; Madruga, Marta S; Queiroga, Rita de Cássia Re

2017-10-01

Fat is the tissue that varies most in animals from both a quantitative and distribution perspective. It plays a fundamental biological role as energy storage during food scarcity. Renal, pelvic and internal fat are deposited first. These fats are used to identify fatty acid profiles that may be considered beneficial or unhealthy. The aim of this study is to evaluate the fatty acid profile of fat depots in Santa Inês sheep finished in confinement with spineless cactus in their diets. The treatments included increasing levels of spineless cactus (Opuntia fícus-indica Mill.): T1 = 0%, T2 = 30%, T3 = 50%, and T4 = 70%. The diets significantly affected the adipose depots. The orthogonal contrast between the diet with no cactus (control) and the other diets indicates that the quantity of saturated fatty acids decreased and that the levels of mono-unsaturated and polyunsaturated fatty acids increased in animals fed spineless cactus. The use of spineless cactus in the diets of Santa Inês sheep affects the lipid profile of their fat depots, reducing the quantity of saturated fatty acids and increasing the quantity of mono-unsaturated and polyunsaturated fatty acids. The fatty acid profile of the fat depots indicates that these fats can be used to formulate meat products and add economic and nutritional value to such products, which increases sheep farmers' incomes. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Simple, Robust Cryogenic Propellant Depot for Near Term Applications

NASA Technical Reports Server (NTRS)

McLean, Christopher; Pitchford, Brian; Mustafi, Shuvo; Wollen, Mark; Walls, Laurie; Schmidt, Jeff

2011-01-01

The ability to refuel cryogenic propulsion stages on-orbit provides an innovative paradigm shift for space transportation supporting National Aeronautics and Space Administration s (NASA) Exploration program as well as deep space robotic, national security and commercial missions. Refueling enables large beyond low Earth orbit (LEO) missions without requiring super heavy lift vehicles that must continuously grow to support increasing mission demands as America s exploration transitions from early Lagrange point missions to near Earth objects (NEO), the lunar surface and eventually Mars. Earth-to-orbit launch can be optimized to provide competitive, cost-effective solutions that allow sustained exploration. This paper describes an experimental platform developed to demonstrate the major technologies required for fuel depot technology. This test bed is capable of transferring residual liquid hydrogen (LH2) or liquid oxygen (LO2) from a Centaur upper stage, and storage in a secondary tank for up to one year on-orbit. A dedicated, flight heritage spacecraft bus is attached to an Evolved Expendable Launch Vehicle (EELV) Secondary Payload Adapter (ESPA) ring supporting experiments and data collection. This platform can be deployed as early as Q1 2013. The propellant depot design described in this paper can be deployed affordably this decade supporting missions to Earth-Moon Lagrange points and lunar fly by. The same depot concept can be scaled up to support more demanding missions and launch capabilities. The enabling depot design features, technologies and concept of operations are described.

Perceptions of the Environment and Health Among Members of the Confederated Tribes of the Umatilla Indian Reservation

PubMed Central

Schure, Marc B.; Kile, Molly L.; Harding, Anna; Harper, Barbara; Harris, Stuart; Uesugi, Sandra; Goins, R. Turner

2014-01-01

Indigenous cultures perceive the natural environment as an essential link between traditional cultural practices, social connectedness, identity, and health. Many tribal communities face substantial health disparities related to exposure to environmental hazards. Our study used qualitative methods to better understand the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) members' perspectives about their environment and its connections with their health including views on environmental health hazards. Three 90-minute focus group sessions with a total of 27 participants were held to elicit opinions on meanings of health and how the environment interacts with health. A systematic text analysis was used to derive themes across focus groups. Participants expressed a holistic view of health that included environmental, physical, mental, spiritual, and social components. A healthy natural environment was identified as an essential component of a healthy individual and a healthy community. Participants also described many environmental health concerns including second-hand smoke, outdoor smoke, diesel exhaust, mold, pesticides, contaminated natural foods, and toxic wastes from the Hanford nuclear site and methamphetamine labs. Many believe the identified environmental hazards contribute to diseases in their community. The natural environment is an important resource to CTUIR members and plays an integral role in achieving and maintaining health. Knowledge about the values and concerns of the community are useful to the tribal and federal governments, health professionals, environmental health practitioners, and community members who seek to achieve sustainable and healthy rural Native communities. PMID:25152803

Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs.

PubMed

Blizzard, Charles; Desai, Ankita; Driscoll, Arthur

2016-11-01

To examine the pharmacokinetic characteristics of sustained-release dexamethasone depots in two separate canine studies. Dexamethasone depots loaded with a clinically representative (0.4 mg) dose (DEXTENZA™; Ocular Therapeutix) or an elevated (0.7 mg) dose were inserted into the canaliculi of beagle eyes (n = 37 and n = 34, respectively). Tear fluid was collected for pharmacokinetic analysis of dexamethasone in both studies at predetermined time points. Explanted 0.4 mg depots were collected weekly to measure remaining drug level. Clinical observations and ophthalmic examinations were performed in both studies at each visit. The 0.4 mg depots released a median 308 μg by day 15 and tapered to complete drug release by day 28. Median dexamethasone tear fluid concentrations in the 0.4 mg study group decreased from 2,805 ng/mL at day 7 to 0 ng/mL on day 28. Median dexamethasone tear fluid concentrations in the 0.7 mg study group decreased from 4,370 ng/mL at 6 h post insertion to 830 ng/mL on day 35. Mean ± standard deviation intraocular pressures in the 0.4 and 0.7 mg study groups were 20.7 ± 2.8 and 19.0 ± 4.1 mmHg at baseline, respectively, and demonstrated no meaningful change (20.5 ± 3.0 and 20.6 ± 2.9 mmHg, respectively) over the studies' durations. No ocular toxicities were attributed to the dexamethasone depot. Sustained-release dexamethasone produced no identifiable ocular toxicity in this animal model, and pharmacokinetics demonstrated a sustained and tapered drug release over 28 days at a 0.4 mg dose and exceeded 35 days at a 0.7 mg dose.

Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue1-3

PubMed Central

Gallagher, Dympna; Kuznia, Patrick; Heshka, Stanley; Albu, Jeanine; Heymsfield, Steven B; Goodpaster, Bret; Visser, Marjolein; Harris, Tamara B

2006-01-01

Background The manner in which fat depot volumes and distributions, particularly the adipose tissue (AT) between the muscles, vary by race is unknown. Objective The objective was to quantify a previously unstudied and novel intermuscular AT (IMAT) depot and subcutaneous AT, visceral AT (VAT), and total-body skeletal muscle mass in healthy sedentary African American (AA), Asian, and white adults by whole-body magnetic resonance imaging. IMAT is the AT between muscles and within the boundary of the muscle fascia. Design Analyses were conducted on 227 women [AA (n = 79): body mass index (BMI; in kg/m2), 29.0 ± 5.5; age, 45.7 ± 16.9 y; Asian (n = 38): BMI, 21.7 ± 2.9; age, 47.2 ± 19.9 y; whites (n = 110): BMI, 24.9 ± 5.4; age, 43.7 ± 16.2 y]) and 111 men [AA (n = 39): BMI, 25.6 ± 3.2; age, 45.5 ± 18.8 y; Asian (n = 13): BMI, 24.9 ± 2.5; age, 45.6 ± 25.0 y; white (n = 59): BMI, 25.8 ± 3.8; age 44.5 ± 16.3 y]. Results IMAT depots were not significantly different in size between race groups at low levels of adiposity; however, with increasing adiposity, AAs had a significantly greater increment in the proportion of total AT (TAT) than did the whites and Asians (58, 46, and 44 g IMAT/kg TAT, respectively; P = 0.001). VAT depots were not significantly different in size at low levels of adiposity but, with increasing adiposity, VAT accumulation was greater than IMAT accumulation in the Asians and whites; no significant differences were observed in AAs. Conclusion Race differences in AT distribution extend to IMAT, a depot that may influence race-ethnicity differences in dysglycemia. PMID:15817870

Cost effectiveness of long-acting risperidone injection versus alternative antipsychotic agents in patients with schizophrenia in the USA.

PubMed

Edwards, Natalie C; Locklear, Julie C; Rupnow, Marcia F T; Diamond, Ronald J

2005-01-01

The availability of long-acting risperidone injection may increase adherence and lead to improved clinical and economic outcomes for individuals with schizophrenia. The objective of this study was to assess the cost effectiveness of long-acting risperidone, oral risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and haloperidol depot in patients with schizophrenia over 1 year from a healthcare system perspective. Published medical literature, unpublished data from clinical trials and a consumer health database, and a clinical expert panel were utilized to populate a decision analytical model comparing the seven treatment alternatives. The model captured rates of patient compliance, the rates, frequency and duration of relapse, incidence of adverse events, and healthcare resource utilization and associated costs. Primary outcomes were expressed in terms of percentage of patients relapsing per year, number of relapse days per year (number and duration of relapses per patient per year), and total direct 2003 medical cost per patient per year. On the basis of model projections, the proportions of patients experiencing a relapse requiring hospitalization in 1 year were 66% for haloperidol depot, 41% for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and 26% for long-acting risperidone, whereas the proportions of patients with an exacerbation not requiring hospitalization were 60% for haloperidol depot, 37% for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and 24% for long-acting risperidone. The mean number of days of relapse requiring hospitalization per patient per year were 28 for haloperidol depot, 18 for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and 11 for long-acting risperidone, whereas the mean number of days of exacerbation not requiring hospitalization were eight for haloperidol depot, five for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and three for long-acting risperidone. This would translate into direct medical cost savings with long-acting risperidone compared with oral risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and haloperidol depot of US dollars 161, 1425, 508, 259, 1068, and 8224, respectively. These findings were supported by sensitivity analyses. The utilization of long-acting risperidone is predicted to result in better clinical outcomes and lower total healthcare costs than its comparators, oral risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and haloperidol depot. Long-acting risperidone may therefore be a cost saving therapeutic option for patients with schizophrenia.

Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots.

PubMed

Probst, Mareike; Kühn, Jens-Peter; Scheuch, Eberhard; Seidlitz, Anne; Hadlich, Stefan; Evert, Katja; Oswald, Stefan; Siegmund, Werner; Weitschies, Werner

2016-04-10

The present pilot study introduces a method that might give novel insights in drug absorption processes from intramuscularly administered depots. An oily suspension or an aqueous solution of paracetamol (6 mg/kg body mass), prednisolone or its hemisuccinate sodium salt for the aqueous solutions (10mg/kg body mass) or diclofenac (10mg/kg body mass) was injected into the muscle tissue of the hind leg of female Lewis-rats (n=47). For the oily suspensions the micronized particles were suspended in medium-chain triglycerides. The aqueous solutions were buffered to a pH of 7.4 ± 0.5. Polyethylene glycol was added as a cosolvent in the formulations containing paracetamol (acetaminophen) and diclofenac and sodium chloride was added to the aqueous solutions of prednisolone hemisuccinate sodium to achieve nearly isotonic formulations. The formed depot was visualized by magnetic resonance imaging (MRI) and characterized with regard to volume and surface area. A 7 T-small animal scanner was used and T1-weighted and T2-weighted sequences including a fat saturation were performed. Simultaneously blood samples were taken and the drugs were quantitatively analyzed. The water based solvent and the oily dispersion agent were visible in the MRI images without the use of contrast agents. Since a free hand injection mostly led to an application directly into the fascia, resulting in a fast removal of the depot, MRI-guided injection was conducted. Comparing pharmacokinetic data with MRI data it was observed that maximal blood levels occurred before the solvent and the dispersion agent were removed from the muscle tissue. Thus, the drug is not absorbed together with the depot. Furthermore, no correlation was found between the shape of the depot and the rate of absorption. Consequently, a higher surface area or volume of the depot did not result in a faster release or absorption of the drugs from the tested formulations. In contrast to the paracetamol and prednisolone formulations the formulations containing diclofenac led to a massive accumulation of interstitial fluid around the injection area being a sign for an acute local reaction. Histological analysis of the muscle tissue revealed a clear correspondence between the amount of interstitial fluid and the extent of infiltrating lymphocytes and granulocytes indicating a tissue response. In conclusion combining MRI with pharmacokinetic data is a suitable method to gain deeper insights into drug absorption processes from intramuscular depots. Furthermore, MRI offers a great possibility detecting local side effects caused by an intramuscularly applied dosage form. This might be very useful in preclinical phases during the development of new intramuscular formulations. Copyright © 2016 Elsevier B.V. All rights reserved.

Sewers as a source and sink of chlorinated-solvent groundwater contamination, Marine Corps Recruit Depot, Parris Island, South Carolina

USGS Publications Warehouse

Vroblesky, D.A.; Petkewich, M.D.; Lowery, M.A.; Landmeyer, J.E.

2011-01-01

Groundwater contamination by tetrachloroethene and its dechlorination products is present in two partially intermingled plumes in the surficial aquifer near a former dry-cleaning facility at Site 45, Marine Corps Recruit Depot, Parris Island, South Carolina. The northern plume originates from the vicinity of former above-ground storage tanks. Free-phase tetrachloroethene from activities in this area entered the groundwater. The southern plume originates at a nearby, new dry-cleaning facility, but probably was the result of contamination released to the aquifer from a leaking sanitary sewer line from the former dry-cleaning facility. Discharge of dissolved groundwater contamination is primarily to leaking storm sewers below the water table. The strong influence of sanitary sewers on source distribution and of storm sewers on plume orientation and discharge at this site indicates that groundwater-contamination investigators should consider the potential influence of sewer systems at their sites. ?? 2011, National Ground Water Association.

Photo-Modulated Therapeutic Protein Release from a Hydrogel Depot Using Visible Light.

PubMed

Basuki, Johan S; Qie, Fengxiang; Mulet, Xavier; Suryadinata, Randy; Vashi, Aditya V; Peng, Yong Y; Li, Lingli; Hao, Xiaojuan; Tan, Tianwei; Hughes, Timothy C

2017-01-19

The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half-life in vivo. Thus there is a need for a drug delivery system that acts as a reservoir and releases the drug remotely "on demand". Here we demonstrate a simple light-triggered local drug delivery system through photo-thermal interactions of polymer-coated gold nanoparticles (AuNPs) inside an agarose hydrogel as therapeutic depot. Localized temperature increase induced by the visible light exposure caused reversible softening of the hydrogel matrix to release the pre-loaded therapeutics. The release profile can be adjusted by AuNPs and agarose concentrations, light intensity and exposure time. Importantly, the biological activity of the released bevacizumab was highly retained. In this study we demonstrate the potential application of this facile AuNPs/hydrogel system for ocular therapeutics delivery through its versatility to release multiple biologics, compatibility to ocular cells and spatiotemporal control using visible light. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Whole tree transportation system for timber processing depots

Treesearch

John Lancaster; Tom Gallagher; Tim  McDonald; Dana Mitchell

2016-01-01

The growing demand for alternative energy has led those who are interested in producing sustainable energy from renewable timber to devise new concepts to satisfy those demands. The concept of timber processing depots, where whole stem trees will be delivered for future processing into wood products and high quality energy fuel, has led to the re-evaluation of our...

Teacher's Guide to Architectural Styles. Skinner's Butte Historical District. Revised Edition.

ERIC Educational Resources Information Center

Bauer, Mary; Neimand, Hahn

This document is a teacher's guide to the historic buildings of Eugene, Oregon. Eighteen buildings in the Skinner's Butte Historical District are highlighted, including the U.S. Post Office, the Eagles Building, the Lane Hotel, the Oregon Electric Depot, the Southern Pacific Railroad Depot, and several houses. For each structure there is a brief…

32 CFR 644.112 - Applicable statutes in condemnation proceedings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... additional permanent air bases and depots, enlarge existing air bases and depots, bombing and machine gun... compensation. (2) Flood control. (i) Act of Congress approved March 1, 1917 (39 Stat. 950, 33 U.S.C. 701) makes...) applicable to flood control works. (ii) Section 6 of the Act of Congress approved August 18, 1941 (55 Stat...

32 CFR 644.112 - Applicable statutes in condemnation proceedings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... additional permanent air bases and depots, enlarge existing air bases and depots, bombing and machine gun... compensation. (2) Flood control. (i) Act of Congress approved March 1, 1917 (39 Stat. 950, 33 U.S.C. 701) makes...) applicable to flood control works. (ii) Section 6 of the Act of Congress approved August 18, 1941 (55 Stat...

32 CFR 644.112 - Applicable statutes in condemnation proceedings.

Code of Federal Regulations, 2012 CFR

2012-07-01

... additional permanent air bases and depots, enlarge existing air bases and depots, bombing and machine gun... compensation. (2) Flood control. (i) Act of Congress approved March 1, 1917 (39 Stat. 950, 33 U.S.C. 701) makes...) applicable to flood control works. (ii) Section 6 of the Act of Congress approved August 18, 1941 (55 Stat...

32 CFR 644.112 - Applicable statutes in condemnation proceedings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... additional permanent air bases and depots, enlarge existing air bases and depots, bombing and machine gun... compensation. (2) Flood control. (i) Act of Congress approved March 1, 1917 (39 Stat. 950, 33 U.S.C. 701) makes...) applicable to flood control works. (ii) Section 6 of the Act of Congress approved August 18, 1941 (55 Stat...

32 CFR 644.112 - Applicable statutes in condemnation proceedings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... additional permanent air bases and depots, enlarge existing air bases and depots, bombing and machine gun... compensation. (2) Flood control. (i) Act of Congress approved March 1, 1917 (39 Stat. 950, 33 U.S.C. 701) makes...) applicable to flood control works. (ii) Section 6 of the Act of Congress approved August 18, 1941 (55 Stat...

Whole tree transportation system for timber processing depots

Treesearch

John Lancaster; Tom Gallagher; Tim McDonald; Dana Mitchell

2017-01-01

The growing demand for alternative energy has led those interested in producing sustainable energy from renewable biomass such as timber to devise new concepts to satisfy those demands. The concept of timber processing depots, where whole stem trees will be delivered for future processing into wood products and high quality energy fuel, has led to the reevaluation of...

75 FR 27185 - Revisions to the Authorization for Validated End-User Applied Materials China, Ltd.

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... Service Center, No. 1 North Di Sheng Street, BDA, Beijing, China 100176. Applied Materials South East Asia..., Shanghai, China 201203. Applied Materials (China), Inc.--Beijing Depot, No. 1 North Di Sheng Street, BDA... Di Sheng Street, BDA Beijing, China 100176. Applied Materials South East Asia Pte. Ltd.-- Wuxi Depot...

The feasibility of solar energy usage on Red River Army Depot. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crowder, G.W.

This feasibility study considers the usage of solar energy to heat and cool the main office buildings on the Red River Army Depot, Texarkana Texas. Solar energy costs are compared with the present heating and cooling system costs with an economic analysis using the annual worth and present worth methods. (GRA)

Early Program Development

NASA Image and Video Library

1971-01-01

This 1971 artist's concept shows a Nuclear Shuttle and an early Space Shuttle docked with an Orbital Propellant Depot. As envisioned by Marshall Space Flight Center Program Development persornel, an orbital modular propellant storage depot, supplied periodically by the Space Shuttle or Earth-to-orbit fuel tankers, would be critical in making available large amounts of fuel to various orbital vehicles and spacecraft.

Front Elevation and Floor Plan in 1893, 1894, and 1909; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Front Elevation and Floor Plan in 1893, 1894, and 1909; Office End Elevation, Waiting End Elevation, Section A (1894), Section B (1894), Signage (ca. 1908-1911), Map of Rail Lines & Depots on Soldiers' Home - National Home for Disabled Volunteer Soldiers, Pacific Branch, Streetcar Depot, Corner of Pershing & Dewey Avenues, Los Angeles, Los Angeles County, CA

On the multiple depots vehicle routing problem with heterogeneous fleet capacity and velocity

NASA Astrophysics Data System (ADS)

Hanum, F.; Hartono, A. P.; Bakhtiar, T.

2018-03-01

This current manuscript concerns with the optimization problem arising in a route determination of products distribution. The problem is formulated in the form of multiple depots and time windowed vehicle routing problem with heterogeneous capacity and velocity of fleet. Model includes a number of constraints such as route continuity, multiple depots availability and serving time in addition to generic constraints. In dealing with the unique feature of heterogeneous velocity, we generate a number of velocity profiles along the road segments, which then converted into traveling-time tables. An illustrative example of rice distribution among villages by bureau of logistics is provided. Exact approach is utilized to determine the optimal solution in term of vehicle routes and starting time of service.

Reconnaissance of Overseas Depot-Level Maintenance.

DTIC Science & Technology

1984-04-01

laboratories; and - military construction investments. Also not included are numerous host-nation contributions such as tax waivers, wage supports, and some...materiel. The TARP workload includes the repair of tactical and combat vehicles, and communications-electronics and construction equipment. Even though...automotive and construction equip- ment, is administered by the 29th Area Support Group, a subordinate activity of the 21st Support Command. At the end of

Microbarograph - ESRL Hi-Res Microbarograph, Umatilla - Reviewed Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCaffrey, Katherine

High-precision barometers (Paroscientific 6000-16B-IS) are combined with Nishiyama-Bedard Quad Disk pressure probes, measuring pressure (mb) at the surface, nominally 2 m above ground level. Data are sampled at 20 Hz for potential studies of turbulence. The sensors' high accuracy makes them useful for determining horizontal pressure gradients and their relation to wind ramp events, as well as the temporal variability of pressure associated with mountain wakes and waves. **Note different ASCII file formats for Goldendale (z04) and Walla Walla (z09) sites.**

Microbarograph - ESRL Hi-Res Microbarograph, Umatilla - Raw Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCaffrey, Katherine

High-precision barometers (Paroscientific 6000-16B-IS) are combined with Nishiyama-Bedard Quad Disk pressure probes, measuring pressure (mb) at the surface, nominally 2 m above ground level. Data are sampled at 20 Hz for potential studies of turbulence. The sensors' high accuracy makes them useful for determining horizontal pressure gradients and their relation to wind ramp events, as well as the temporal variability of pressure associated with mountain wakes and waves. **Note different ASCII file formats for Goldendale (z04) and Walla Walla (z09) sites.**

Implants and depot injections for treating opioid dependence: Qualitative study of people who use or have used heroin.

PubMed

Neale, Joanne; Tompkins, Charlotte N E; McDonald, Rebecca; Strang, John

2018-05-25

Long-acting opioid pharmacotherapy (OPT) is presumed to offer benefits over more conventional OPT formulations. This paper analyzes the views and experiences of people who use or have used heroin in order to explore two novel systems for delivering long-acting OPT: implants and depot injections. New materialism theorizing is used to interpret and frame the findings. Qualitative data were generated via seven focus groups conducted during 2017 in London, UK. Participants (n = 44; 28 men and 16 women; ages 33-66 years) had all received OPT. Focus group discussions covered real and potential OPT delivery systems. All participant data relating to implants and depot injections were coded using MAXQDA software and analysed inductively via Iterative Categorisation. Participants discussed implants and depot injections in terms of interacting physical, psychological and social factors: dose stability; OPT administration; stopping treatment; co-presence of an antagonist; breaking rituals and habits; reduced choice and control; feeling normal; information needs; getting on with everyday life; and social interaction. Participants identified both benefits and concerns, and variable needs and preferences, with respect to each delivery system. Implants and depot injections are not 'fixed' medications that can be administered to people to achieve pre-determined treatment aims. Rather, they are complex 'assemblages' with uncertain outcomes. Furthermore, they are themselves part of wider interactive 'assemblages'. Drug developers and treatment providers need to understand this complexity in order to target long-acting OPT at people most likely to benefit from it, and to reduce any unintended negative consequences. Copyright © 2018 Elsevier B.V. All rights reserved.

Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation.

PubMed

Li, Ruixiang; Pang, Zhiqing; He, Huining; Lee, Seungjin; Qin, Jing; Wu, Jian; Pang, Liang; Wang, Jianxin; Yang, Victor C

2017-09-10

Localized and long-term delivery of growth factors has been a long-standing challenge for stem cell-based tissue engineering. In the current study, a polymeric drug depot-anchoring hydrogel scaffold was developed for the sustained release of macromolecules to enhance the differentiation of stem cells. Self-assembling peptide (RADA16)-modified drug depots (RDDs) were prepared and anchored to a RADA16 hydrogel. The anchoring effect of RADA16 modification on the RDDs was tested both in vitro and in vivo. It was shown that the in vitro leakage of RDDs from the RADA16 hydrogel was significantly less than that of the unmodified drug depots (DDs). In addition, the in vivo retention of injected hydrogel-incorporated RDDs was significantly longer than that of hydrogel-incorporated unmodified DDs. A model drug, vascular endothelial growth factor (VEGF), was encapsulated in RDDs (V-RDDs) as drug depot that was then anchored to the hydrogel. The release of VEGF could be sustained for 4weeks. Endothelial progenitor cells (EPCs) were cultured on the V-RDDs-anchoring scaffold and enhanced cell proliferation and differentiation were observed, compared with a VEGF-loaded scaffold. Furthermore, this scaffold laden with EPCs promoted neovascularization in an animal model of hind limb ischemia. These results demonstrate that self-assembling hydrogel-anchored drug-loaded RDDs are promising for localized and sustained drug release, and can effectively enhance the proliferation and differentiation of resident stem cells, thus lead to successful tissue regeneration. Copyright © 2017. Published by Elsevier B.V.

Lymphatic-targeted cationic liposomes: a robust vaccine adjuvant for promoting long-term immunological memory.

PubMed

Wang, Ce; Liu, Peng; Zhuang, Yan; Li, Ping; Jiang, Boling; Pan, Hong; Liu, Lanlan; Cai, Lintao; Ma, Yifan

2014-09-22

Although retaining antigens at the injection site (the so-called "depot effect") is an important strategy for vaccine development, increasing evidence showed that lymphatic-targeted vaccine delivery with liposomes could be a promising approach for improving vaccine efficacy. However, it remains unclear whether antigen depot or lymphatic targeting would benefit long-term immunological memory, a major determinant of vaccine efficacy. In the present study, OVA antigen was encapsulated with DOTAP cationic liposomes (LP) or DOTAP-PEG-mannose liposomes (LP-Man) to generate depot or lymphatic-targeted liposome vaccines, respectively. The result of in vivo imaging showed that LP mostly accumulated near the injection site, whereas LP-Man not only effectively accumulated in draining lymph nodes (LNs) and the spleen, but also enhanced the uptake by resident antigen-presenting cells. Although LP vaccines with depot effect induced anti-OVA IgG more potently than LP-Man vaccines did on day 40 after priming, they failed to mount an effective B-cell memory response upon OVA re-challenge after three months. In contrast, lymphatic-targeted LP-Man vaccines elicited sustained antibody production and robust recall responses three months after priming, suggesting lymphatic targeting rather than antigen depot promoted the establishment of long-term memory responses. The enhanced long-term immunological memory by LP-Man was attributed to vigorous germinal center responses as well as increased Tfh cells and central memory CD4(+) T cells in the secondary lymphoid organs. Hence, lymphatic-targeted vaccine delivery with LP-Man could be an effective strategy to promote long-lasting immunological memory. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Treatment of Adult Schizophrenic Patients With Depot Antipsychotics].

PubMed

Jaramillo González, Luis Eduardo; Gómez Restrepo, Carlos; García Valencia, Jenny; de la Hoz Bradford, Ana María; Ávila-Guerra, Mauricio; Bohórquez Peñaranda, Adriana

2014-01-01

To determine the indications of long-acting antipsychotic injection and what its effectiveness and safety in adult patients with schizophrenia during the treatment maintenance phase. A clinical practice guideline was elaborated under the parameters of the Methodological Guide of the Ministerio de Salud y Protección Social to identify, synthesize and evaluate the evidence and make recommendations about the treatment and follow-up of adult patients with schizophrenia. The evidence of NICE guide 82 was adopted and updated. The evidence was presented to the Guideline Developing Group and recommendations, employing the GRADE system, were produced. The literature review shows that the evidence has moderate to low quality. 8 articles were used. The risk of relapse was lower with depot risperidone and paliperidone palmitate when compared with placebo. For the risk of hospitalizations comparing depot antipsychotics (APD) versus oral AP, the result is inconclusive. Globally the second-generation APD had a lower risk of discontinuation when compared with placebo. The second generation AP had higher risk of extrapyramidal syndromes than placebo, as in the use of antiparkinsonian. The comparison of second-generation AP injections versus placebo showed an increased risk of early weight gain. The use of depot antipsychotics in the maintenance phase of adult patients diagnosed with schizophrenia is recommended if there is no adherence to oral antipsychotics as the patient's preference. It is not recommended depot antipsychotics in the acute phase of schizophrenia in adults. Copyright © 2014 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

Involvement of sympathetic nervous system and brown fat in endotoxin-induced fever in rats.

PubMed

Jepson, M M; Millward, D J; Rothwell, N J; Stock, M J

1988-11-01

The object of this study was to assess the role of brown adipose tissue (BAT) and the sympathetic nervous system in the rise in heat production associated with endotoxin-induced fever. Oxygen consumption (VO2) was found to be significantly increased (28%) over a 4-h period after two doses of endotoxin (Escherichia coli lipopolysaccharide, 0.3 mg/100 g body wt) given 24 h apart. Injection of a mixed beta-adrenoceptor antagonist (propranolol) reduced VO2 by 14% in endotoxin-treated rats, whereas the selective beta 1- (atenolol) or beta 2- (ICI 118551) antagonists suppressed VO2 by 10%. These drugs did not affect VO2 in control animals. BAT thermogenic activity assessed from measurements of in vitro mitochondrial guanosine 5'-diphosphate (GDP) binding was elevated by 54% in interscapular BAT and by 171% in other BAT depots. Surgical denervation of one lobe of the interscapular depot prevented these responses. Endotoxin failed to stimulate GDP binding in rats fed protein-deficient diets. This may have been because BAT thermogenic activity was already elevated in control rats fed these diets or because endotoxin caused a marked suppression of food intake in the protein-deficient animals. The results indicate that sympathetic activation of BAT is involved in the thermogenic responses to endotoxin and that these can be modified by dietary manipulation.

Community Environmental Response Facilitation Act (CERFA) Report, Sacramento Army Depot, Sacramento, California

DTIC Science & Technology

1994-04-01

Response, Compensation, and Liability Information System CERFA Community Environmental Response Facilitation Act CORTESE State-designated hazardous...waste cleanup sites DESCOM U.S. Army Depot Systems Command DTSC Department of Toxic Substance Control EMD Environmental Management Division EPA U.S...Environmental Protection Agency ERNS Emergency Response Notification system FFA Federal Facility Agreement FINDS Facility index system HWCSA Hazardous

Telerobotics for depot modernization

NASA Technical Reports Server (NTRS)

Leahy, M. B., Jr.; Petroski, S. B.

1994-01-01

Development and application of telerobotics technology for the enhancement of the quality of the Air Logistic Centers (ALC) repair and remanufacturing processes is described. Telerobotics provides the means for bridging the gap between manual operation and full automation. The Robotics and Automation Center for Excellence (RACE) initiated the Unified Telerobotics Architecture Project (UTAP) to support the development and application of telerobotics for depot operation.

33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek, and Broad River... danger zone on Archers Creek (between the Broad River and Beaufort River), Ribbon Creek, and the Broad...

33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek, and Broad River... danger zone on Archers Creek (between the Broad River and Beaufort River), Ribbon Creek, and the Broad...

33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek, and Broad River... danger zone on Archers Creek (between the Broad River and Beaufort River), Ribbon Creek, and the Broad...

Evaluation of Low Hazardous Air Pollutant Thermoset Adhesives for the Application of Rubber-to-Metal Bonding on Army Tank Pads and Road Wheels

DTIC Science & Technology

2011-09-01

Department of the Army. Track Shoe Rebuild; SOP 39; Red River Army Depot, Texarkana , Texas, July 2, 2002. 3. Operational Directorate, Department...of the Army. Rebuild of Wheel, Solid Rubber Tire; SOP 47; Red River Army Depot, Texarkana , Texas, July 15, 2002. 4. Chemcentral Corporation

Defense Environmental Restoration Program Annual Report to Congress for Fiscal Year 1986

DTIC Science & Technology

1987-03-16

LF 01 LANDFILL $3 AND HAROFILL RUFS C SITE LF 02 LANDFILL I RI C SITE LF 03 LANDFILL 2 RI C SITE LU 01 BLDG 2017 -BEA ABANDONED UST FS C SITE tU 02 BLDG...Army Amiunition Plant, Texarkana Hill Air force Base, Ogden Ogden Defense Depot, Ogden Toele Army Depot, Tooele VIFIOIA Defense General Supply Center

An Empirical Investigation of USAF Logistics Readiness Officer Mission Sets

DTIC Science & Technology

2013-03-01

parts, engine repair and 7 spare utilization, fuel cell and fuel system related repairs, heavy maintenance and inspection functions, and aircraft...provide additional mission sets. Fuels Management, Program Management, Acquisitions Management, and Depot Maintenance were suggested once each as...being mentioned by 2.5 percent ( Fuels Management, Program Management, Acquisitions Management, and Depot Maintenance) and 5 percent (Human Capital

Development and testing for physical security robots

NASA Astrophysics Data System (ADS)

Carroll, Daniel M.; Nguyen, Chinh; Everett, H. R.; Frederick, Brian

2005-05-01

The Mobile Detection Assessment Response System (MDARS) provides physical security for Department of Defense bases and depots using autonomous unmanned ground vehicles (UGVs) to patrol the site while operating payloads for intruder detection and assessment, barrier assessment, and product assessment. MDARS is in the System Development and Demonstration acquisition phase and is currently undergoing developmental testing including an Early User Appraisal (EUA) at the Hawthorne Army Depot, Nevada-the world's largest army depot. The Multiple Resource Host Architecture (MRHA) allows the human guard force to command and control several MDARS platforms simultaneously. The MRHA graphically displays video, map, and status for each resource using wireless digital communications for integrated data, video, and audio. Events are prioritized and the user is prompted with audio alerts and text instructions for alarms and warnings. The MRHA also interfaces to remote resources to automate legacy physical devices such as fence gate controls, garage doors, and remote power on/off capability for the MDARS patrol units. This paper provides an overview and history of the MDARS program and control station software with details on the installation and operation at Hawthorne Army Depot, including discussions on scenarios for EUA excursions. Special attention is given to the MDARS technical development strategy for spiral evolutions.

Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system

PubMed Central

Zhang, Shanshan; Anderson, Mark A.; Ao, Yan; Khakh, Baljit S.; Fan, Jessica; Deming, Timothy J.; Sofroniew, Michael V.

2014-01-01

Many hydrophobic small molecules are available to regulate gene expression and other cellular functions. Locally restricted application of such molecules in the central nervous system (CNS) would be desirable in many experimental and therapeutic settings, but is limited by a lack of innocuous vehicles able to load and easily deliver hydrophobic cargo. Here, we tested the potential for diblock copolypeptide hydrogels (DCH) to serve as such vehicles. In vitro tests on loading and release were conducted with cholesterol and the anti-cancer agent, temozolomide (TMZ). Loading of hydrophobic cargo modified DCH physical properties such as stiffness and viscosity, but these could readily be tuned to desired ranges by modifying DCH concentration, amino acid composition or chain lengths. Different DCH formulations exhibited different loading capacities and different rates of release. For example, comparison of different DCH with increasing alanine contents showed corresponding increases in both cargo loading capacity and time for cargo release. In vivo tests were conducted with tamoxifen, a small synthetic hydrophobic molecule widely used to regulate transgene expression. Tamoxifen released from DCH depots injected into healthy or injured CNS efficiently activated reporter gene expression in a locally restricted manner in transgenic mice. These findings demonstrate the facile and predictable tunability of DCH to achieve a wide range of loading capacities and release profiles of hydrophobic cargos while retaining CNS compatible physical properties. In addition, the findings show that DCH depots injected into the CNS can efficiently deliver small hydrophobic molecules that regulate gene expression in local cells. PMID:24314556

Strategic supply system design - a holistic evaluation of operational and production cost for a biorefinery supply chain

DOE PAGES

Lamers, Patrick; Tan, Eric C. D.; Searcy, Erin M.; ...

2015-08-20

Here, pioneer cellulosic biorefineries across the United States rely on a conventional feedstock supply system based on one-year contracts with local growers, who harvest, locally store, and deliver feed-stock in low-density format to the conversion facility. While the conventional system is designed for high biomass yield areas, pilot scale operations have experienced feedstock supply shortages and price volatilities due to reduced harvests and competition from other industries. Regional supply dependency and the inability to actively manage feedstock stability and quality, provide operational risks to the biorefinery, which translate into higher investment risk. The advanced feedstock supply system based on amore » network of depots can mitigate many of these risks and enable wider supply system benefits. This paper compares the two concepts from a system-level perspective beyond mere logistic costs. It shows that while processing operations at the depot increase feedstock supply costs initially, they enable wider system benefits including supply risk reduction (leading to lower interest rates on loans), industry scale-up, conversion yield improvements, and reduced handling equipment and storage costs at the biorefinery. When translating these benefits into cost reductions per liter of gasoline equivalent (LGE), we find that total cost reductions between -0.46 to -0.21 per LGE for biochemical and -0.32 to -0.12 per LGE for thermochemical conversion pathways are possible. Naturally, these system level benefits will differ between individual actors along the feedstock supply chain. Further research is required with respect to depot sizing, location, and ownership structures.« less

Developmental programming, adiposity, and reproduction in ruminants.

PubMed

Symonds, M E; Dellschaft, N; Pope, M; Birtwistle, M; Alagal, R; Keisler, D; Budge, H

2016-07-01

Although sheep have been widely adopted as an animal model for examining the timing of nutritional interventions through pregnancy on the short- and long-term outcomes, only modest programming effects have been seen. This is due in part to the mismatch in numbers of twins and singletons between study groups as well as unequal numbers of males and females. Placental growth differs between singleton and twin pregnancies which can result in different body composition in the offspring. One tissue that is especially affected is adipose tissue which in the sheep fetus is primarily located around the kidneys and heart plus the sternal/neck region. Its main role is the rapid generation of heat due to activation of the brown adipose tissue-specific uncoupling protein 1 at birth. The fetal adipose tissue response to suboptimal maternal food intake at defined stages of development differs between the perirenal abdominal and pericardial depots, with the latter being more sensitive. Fetal adipose tissue growth may be mediated in part by changes in leptin status of the mother which are paralleled in the fetus. Then, over the first month of life plasma leptin is higher in females than males despite similar adiposity, when fat is the fastest growing tissue with the sternal/neck depot retaining uncoupling protein 1, whereas other depots do not. Future studies should take into account the respective effects of fetal number and sex to provide more detailed insights into the mechanisms by which adipose and related tissues can be programmed in utero. Copyright © 2016 Elsevier Inc. All rights reserved.

Strategic supply system design - a holistic evaluation of operational and production cost for a biorefinery supply chain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamers, Patrick; Tan, Eric C. D.; Searcy, Erin M.

Here, pioneer cellulosic biorefineries across the United States rely on a conventional feedstock supply system based on one-year contracts with local growers, who harvest, locally store, and deliver feed-stock in low-density format to the conversion facility. While the conventional system is designed for high biomass yield areas, pilot scale operations have experienced feedstock supply shortages and price volatilities due to reduced harvests and competition from other industries. Regional supply dependency and the inability to actively manage feedstock stability and quality, provide operational risks to the biorefinery, which translate into higher investment risk. The advanced feedstock supply system based on amore » network of depots can mitigate many of these risks and enable wider supply system benefits. This paper compares the two concepts from a system-level perspective beyond mere logistic costs. It shows that while processing operations at the depot increase feedstock supply costs initially, they enable wider system benefits including supply risk reduction (leading to lower interest rates on loans), industry scale-up, conversion yield improvements, and reduced handling equipment and storage costs at the biorefinery. When translating these benefits into cost reductions per liter of gasoline equivalent (LGE), we find that total cost reductions between -0.46 to -0.21 per LGE for biochemical and -0.32 to -0.12 per LGE for thermochemical conversion pathways are possible. Naturally, these system level benefits will differ between individual actors along the feedstock supply chain. Further research is required with respect to depot sizing, location, and ownership structures.« less

Endurance exercise training induces fat depot-specific differences in basal autophagic activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanaka, Goki; Kato, Hisashi; Izawa, Tetsuya, E-mail: tizawa@mail.doshisha.ac.jp

The purpose of this study was to uncover the effect of exercise training on the expression of autophagy marker proteins in epididymal white adipose tissue (eWAT), inguinal WAT (iWAT), and the stromal vascular fraction (SVF) collected from eWAT. Male Wistar rats aged 4–5 weeks were randomly divided into two groups, sedentary control (n = 7) and exercise-trained (n = 7). Rats in the exercise-trained group were exercised on a treadmill set at a 5° incline 5 days/week for 9 weeks. We determined that the expression levels of an autophagosome-associating form of microtubule-associated protein 1 light chain 3 (LC3)-II and of p62 were significantly highermore » in eWAT from exercise-trained than from control rats, while those of adipose-specific deletion of autophagy-related protein (ATG7) and lysosomal-associated membrane protein type 2A (LAMP2a) showed no difference between groups. However, in iWAT, the expression levels of LC3-II and ATG7 were significantly higher in exercise-trained than in control rats. The expression of p62 was highly correlated with that of peroxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipogenesis and lipid metabolism, in both WAT types (eWAT, r = 0.856, P < 0.05; iWAT, r = 0.762, P < 0.05), whereas LC3-II and PPARγ levels were highly correlated in eWAT (r = 0.765, P < 0.05) but not in iWAT (r = −0.306, ns). In SVF, the expression levels of LC3II, ATG7, and LAMP2a were significantly higher in exercise-trained than in control rats. These results suggest that exercise training suppresses basal autophagy activity in eWAT, but that this activity is enhanced in iWAT and SVF collected from eWAT. Thus, the adaptation of basal autophagic activity following exercise training exhibits fat depot-specific differences. - Highlights: • Autophagy has been associated with obesity and associated diseases. • We examined exercise-associated rat white adipose tissue (WAT) autophagy markers. • Exercise increased autophagosome associated LC3-II in WAT. • Exercise-induced changes in p62 and ATG7 were WAT-type specific. • Exercise-induced basal autophagic activity shows fat depot-specific differences.« less

Preliminary Assessment/Site Investigation: Tooele Army Depot, Utah. Volume 1. North Area and Facilities at Hill Air Force Base. Appendixes

DTIC Science & Technology

1988-12-01

the number of 2) Facilities occunied b, Army activities other than DA forms are prohibited without copies requested in Blocks 356 of the sub-e o e...scriber’s DA Form 12-QA-R. AR 420-76as tenants when reai property control is pr i o r approv al from HQDA distrbution is C for Active Army. ARNG. uner...quality 9 3-5 Records and reporting requirements (RCS Chief of Engineers * 2-1 Nonapproprnated fund activities * 3-6 DD-M (A&AR) 1080) • 4-4 Major Army

Pilot-Scale Demonstration of In-Situ Chemical Oxidation Involving Chlorinated Volatile Organic Compounds - Design and Deployment Guidelines (Parris Island, SC, U.S. Marine Corp Recruit Depot, Site 45 Pilot Study)

EPA Science Inventory

A pilot-scale in situ chemical oxidation (ISCO) demonstration, involving subsurface injections of sodium permanganate (NaMnO4), was performed at the US Marine Corp Recruit Depot (MCRD), site 45 (Parris Island (PI), SC). The ground water was originally contaminated with perchloroe...

33 CFR 334.480 - Archers Creek, Ribbon Creek and Broad River, S.C.; U.S. Marine Corps Recruit Depot rifle and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Broad River, S.C.; U.S. Marine Corps Recruit Depot rifle and pistol ranges, Parris Island. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek and Broad River... navigation: (1) At the rifle range. Archers Creek between Broad River and Beaufort River and Ribbon Creek...

33 CFR 334.480 - Archers Creek, Ribbon Creek and Broad River, S.C.; U.S. Marine Corps Recruit Depot rifle and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Broad River, S.C.; U.S. Marine Corps Recruit Depot rifle and pistol ranges, Parris Island. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek and Broad River... navigation: (1) At the rifle range. Archers Creek between Broad River and Beaufort River and Ribbon Creek...

76 FR 35379 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island, SC...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

..., Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island, SC; Danger Zone AGENCY... use these portions of Archers Creek, Ribbon Creek, and the Broad River when the rifle and pistol.... 334.480 to read as follows: Sec. 334.480 Archers Creek, Ribbon Creek, and Broad River; U.S. Marine...

A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice

PubMed Central

Grove, KL; Fried, SK; Greenberg, AS; Xiao, XQ; Clegg, DJ

2013-01-01

Objective A sexual dimorphism exists in body fat distribution; females deposit relatively more fat in subcutaneous/inguinal depots whereas males deposit more fat in the intra-abdominal/gonadal depot. Our objective was to systematically document depot- and sex-related differences in the accumulation of adipose tissue and gene expression, comparing differentially expressed genes in diet-induced obese mice with mice maintained on a chow diet. Research Design and Methods We used a microarray approach to determine whether there are sexual dimorphisms in gene expression in age-matched male, female or ovariectomized female (OVX) C57/BL6 mice maintained on a high-fat (HF) diet. We then compared expression of validated genes between the sexes on a chow diet. Results After exposure to a high fat diet for 12 weeks, females gained less weight than males. The microarray analyses indicate in intra-abdominal/gonadal adipose tissue in females 1642 genes differ by at least twofold between the depots, whereas 706 genes differ in subcutaneous/inguinal adipose tissue when compared with males. Only 138 genes are commonly regulated in both sexes and adipose tissue depots. Inflammatory genes (cytokine–cytokine receptor interactions and acute-phase protein synthesis) are upregulated in males when compared with females, and there is a partial reversal after OVX, where OVX adipose tissue gene expression is more ′male-like′. This pattern is not observed in mice maintained on chow. Histology of male gonadal white adipose tissue (GWAT) shows more crown-like structures than females, indicative of inflammation and adipose tissue remodeling. In addition, genes related to insulin signaling and lipid synthesis are higher in females than males, regardless of dietary exposure. Conclusions These data suggest that male and female adipose tissue differ between the sexes regardless of diet. Moreover, HF diet exposure elicits a much greater inflammatory response in males when compared with females. This data set underscores the importance of analyzing depot-, sex- and steroid-dependent regulation of adipose tissue distribution and function. PMID:20157318

Adherence to depot versus oral antipsychotic medication in schizophrenic patients during the long-term therapy.

PubMed

Stanković, Zana; Ille, Tatjana

2013-03-01

There is a high rate of schizophrenic patients who do not adhere to their prescribed therapy, despite the implementation of antipsychotic long-acting injections and the introduction of atypical antipsychotics. The aim of this study was to investigate the differences in sociodemographic, clinical and medication adherence variables between the two groups of schizophrenic patients on maintenance therapy with depot antipsychotic fluphenazine decanoate and oral antipsychotics only as well as a correlation between the medication adherence and other examined variables. A total of 56 patients of both genders, aged < 60 years, with the diagnosis of schizophrenia (F20) (ICD-10, 1992) clinically stable for at least 6 months were introduced in this cross-sectional study. The patients from the depot group (n = 19) were on classical depot antipsychotic fluphenazine decanoate administering intramuscularly every 4 weeks (with or without oral antipsychotic augmentation) and the patients from the oral group (n = 37) were on oral therapy alone with classical or atypical antipsychotics, either as monotherapy or combined. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Item G12 of the PANSS was used to assess insight into the illness. The patients completed the Medical Adherence Rating Scale (MARS) was used to assess adherence to the therapy. A higher MARS score indicates behavior [Medical Adherence Questionnaire (MAQ subscale)] and attitudes toward medication [Drug Attitude Inventory (DAI subscale)] that are more consistent with treatment adherence. The exclusion criteria were determined. The Pearson's chi2 test was used to compare categorical variables, Student's t-test to compare continuous variables and Pearson's correlation to test the correlation significance; p = 0.05. Significant between-group differences in age, illness duration, chlorpromazine equivalents, PANSS score and DAI subscore were found. Item G12 of the PANSS subscore and MARS score correlated significantly negatively. A significant positive correlation between receiving depot antipsychotic and DAI subscore as well as between illness duration and both DAI subscore and MARS score were also found. Schizophrenic patients on classical depot antipsychotic maintenance therapy might present subpopulation of patients with significantly longer illness duration, more favorable medication attitude and outcome in relation to those on oral antipsychotics alone.

A novel approach using a minimal number of injections during the IVF/ICSI cycle: Luteal half-dose depot GnRH agonist following corifollitropin alfa versus the corifollitropin alfa with a GnRH-antagonist cycle.

PubMed

Haydardedeoğlu, Bülent; Kılıçdağ, Esra Bulgan

2016-01-01

Corifollitropin alfa is a good choice for assisted reproductive technology (ART) cycles because fewer injections are needed than with other agents. In this retrospective cohort, we analyzed luteal injected half-dose depot gonadotropin hormone-releasing hormone (GnRH) agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist. In this retrospective cohort, we analyzed luteal injected half-dose depot GnRH agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist at the Division of Reproductive Endocrinology and IVF Unit, Obstetrics and Gynecology Department, Başkent University School of Medicine, Adana, Turkey, from March 2014 to August 2015. The patient's baseline characteristics were similar between the two groups. Forty-five patients underwent the long protocol, in which a half-dose of depot GnRH agonist was administered on day 21 of the preceding cycle. Forty-nine patients underwent the GnRH-antagonist protocol. Corifollitropin alfa was administered on the menstrual cycle day 3. The mean ages of the two groups were similar (32.77±5.55 vs. 34.2±4.51 years ["for the long- and antagonist-protocol groups, respectively"]). The total number of retrieved oocytes, the fertilization rate, and the number of transferred embryos were similar between the two groups. The only significant difference between the two protocols was the number of injections during the controlled ovarian stimulation (COH) cycle, which included the depot-agonist injection in the long-protocol group (4.46±1.64 vs. 5.71±2.51, p=0.006). The clinical pregnancy and implantation rates were similar in the two protocols (16/45 [35.6%] vs. 16/49 [32.7%] for the intention to treat and 32.5±6.82% vs. 36.25±8.58%, respectively). Our results show that ART cycles could be performed with fewer injections using corifollitropin alfa and a half-dose of depot GnRH agonist.

In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds.

PubMed

Lin, Wei-Chih; Huang, Chieh-Cheng; Lin, Shu-Jyuan; Li, Meng-Ju; Chang, Yen; Lin, Yu-Jung; Wan, Wei-Lin; Shih, Po-Chien; Sung, Hsing-Wen

2017-11-01

Patients with diabetes mellitus are prone to develop refractory wounds. They exhibit reduced synthesis and levels of circulating hydrogen sulfide (H 2 S), which is an ephemeral gaseous molecule. Physiologically, H 2 S is an endogenous gasotransmitter with multiple biological functions. An emulsion method is utilized to prepare a microparticle system that comprises phase-change materials with a nearly constant temperature of phase transitions to encapsulate sodium hydrosulfide (NaHS), a highly water-labile H 2 S donor. An emulsion technique that can minimize the loss of water-labile active compounds during emulsification must be developed. The as-prepared microparticles (NaHS@MPs) provide an in situ depot for the sustained release of exogenous H 2 S under physiological conditions. The sustained release of H 2 S promotes several cell behaviors, including epidermal/endothelial cell proliferation and migration, as well as angiogenesis, by extending the activation of cellular ERK1/2 and p38, accelerating the healing of full-thickness wounds in diabetic mice. These experimental results reveal the strong potential of NaHS@MPs for the sustained release of H 2 S for the treatment of diabetic wounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice[S

PubMed Central

Archer, Amena; Stolarczyk, Émilie; Doria, Maria Luisa; Helguero, Luisa; Domingues, Rosário; Howard, Jane K.; Mode, Agneta; Korach-André, Marion; Gustafsson, Jan-Åke

2013-01-01

To investigate the role of liver X receptor (LXR) in adipose tissue metabolism during obesity, ob/ob mice were treated for 5 weeks with the synthetic LXR agonist GW3965. MRI analysis revealed that pharmacological activation of LXR modified fat distribution by decreasing visceral (VS) fat and inversely increasing subcutaneous (SC) fat storage without affecting whole body fat content. This was concordant with opposite regulation by GW3965 of the lipolytic markers hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) in the two fat depots; moreover, the expression of genes involved in lipogenesis was significantly induced in SC fat. Lipidomic analysis suggested that changes in lipid composition in response to GW3965 also varied between VS and SC fat. In both depots, the observed alteration in lipid composition indicated an overall change toward less lipotoxic lipids. Flow cytometry analysis showed decreased immune cell infiltration in adipose tissue of ob/ob mice in response to GW3965 treatment, which in VS fat mainly affected the macrophage population and in SC fat the lymphocyte population. In line with this, the expression and secretion of proinflammatory markers was decreased in both fat deposits with GW3965 treatment. PMID:23446231

EQUIFAT: A novel scoring system for the semi-quantitative evaluation of regional adipose tissues in Equidae.

PubMed

Morrison, Philippa K; Harris, Patricia A; Maltin, Charlotte A; Grove-White, Dai; Argo, Caroline McG

2017-01-01

Anatomically distinct adipose tissues represent variable risks to metabolic health in man and some other mammals. Quantitative-imaging of internal adipose depots is problematic in large animals and associations between regional adiposity and health are poorly understood. This study aimed to develop and test a semi-quantitative system (EQUIFAT) which could be applied to regional adipose tissues. Anatomically-defined, photographic images of adipose depots (omental, mesenteric, epicardial, rump) were collected from 38 animals immediately post-mortem. Images were ranked and depot-specific descriptors were developed (1 = no fat visible; 5 = excessive fat present). Nuchal-crest and ventro-abdominal-retroperitoneal adipose depot depths (cm) were transformed to categorical 5 point scores. The repeatability and reliability of EQUIFAT was independently tested by 24 observers. When half scores were permitted, inter-observer agreement was substantial (average κw: mesenteric, 0.79; omental, 0.79; rump 0.61) or moderate (average κw; epicardial, 0.60). Intra-observer repeatability was tested by 8 observers on 2 occasions. Kappa analysis indicated perfect (omental and mesenteric) and substantial agreement (epicardial and rump) between attempts. A further 207 animals were evaluated ante-mortem (age, height, breed-type, gender, body condition score [BCS]) and again immediately post-mortem (EQUIFAT scores, carcass weight). Multivariable, random effect linear regression models were fitted (breed as random effect; BCS as outcome variable). Only height, carcass weight, omental and retroperitoneal EQUIFAT scores remained as explanatory variables in the final model. The EQUIFAT scores developed here demonstrate clear functional differences between regional adipose depots and future studies could be directed towards describing associations between adiposity and disease risk in surgical and post-mortem situations.

Safer injections following a new national medicine policy in the public sector, Burkina Faso 1995 – 2000

PubMed Central

Logez, Sophie; Hutin, Yvan; Somda, Paul; Thuault, Jérôme; Holloway, Kathleen

2005-01-01

Background The common failure of health systems to ensure adequate and sufficient supplies of injection devices may have a negative impact on injection safety. We conducted an assessment in April 2001 to determine to which extent an increase in safe injection practices between 1995 and 2000 was related to the increased access to injection devices because of a new essential medicine policy in Burkina Faso. Methods We reviewed outcomes of the new medicine policy implemented in1995. In April 2001, a retrospective programme review assessed the situation between 1995 and 2000. We visited 52 health care facilities where injections had been observed during a 2000 injection safety assessment and their adjacent operational public pharmaceutical depots. Data collection included structured observations of available injection devices and an estimation of the proportion of prescriptions including at least one injection. We interviewed wholesaler managers at national and regional levels on supply of injection devices to public health facilities. Results Fifty of 52 (96%) health care facilities were equipped with a pharmaceutical depot selling syringes and needles, 37 (74%) of which had been established between 1995 and 2000. Of 50 pharmaceutical depots, 96% had single-use 5 ml syringes available. At all facilities, patients were buying syringes and needles out of the depot for their injections prescribed at the dispensary. While injection devices were available in greater quantities, the proportion of prescriptions including at least one injection remained stable between 1995 (26.5 %) and 2000 (23.8 %). Conclusion The implementation of pharmaceutical depots next to public health care facilities increased geographical access to essential medicines and basic supplies, among which syringes and needles, contributing substantially to safer injection practices in the absence of increased use of therapeutic injections. PMID:16364178

Occupational exposure of petroleum depot workers to BTEX compounds.

PubMed

Rezazadeh Azari, M; Naghavi Konjin, Z; Zayeri, F; Salehpour, S; Seyedi, M D

2012-01-01

Benzene, toluene, ethylbenzene and xylene (BTEX) are the most important toxic volatile compounds in the air and could be easily absorbed through the respiratory tract. In recent years, the risk of exposure to BTEX compounds, especially benzene as a carcinogen, has been considered in petroleum depot stations. To assess the occupational exposure of petroleum depot workers in Iran to BTEX compounds. After completing a questionnaire and assessing occupational exposure to BTEX compounds, 78 (46 exposed and 32 non-exposed) depot workers were randomly selected to participate in this study. Air sampling and analysis of BTEX was conducted according to the NIOSH method No. 1501. Analysis of urinary hippuric acid, as an indicator of toluene exposure, was carried out according to NIOSH method No. 8300. Personal monitoring of the high exposure group to BTEX compounds was repeated to verify the results obtained in the first phase of the monitoring. Among the 9 operating groups studied, occupational exposure to benzene and toluene was higher in quality control and gasoline loading operators-the median exposure ranged from 0.16 to 1.63 ppm for benzene and 0.2 to 2.72 ppm for toluene. Median exposure of other group members to BTEX compounds was below the detection limit of analytical method (0.07, 0.06, 0.05, and 0.05 ppm, respectively). The level of toluene exposure measured showed correlation with neither post-shift urinary hippuric acid (Spearman's rho = 0.128, p = 0.982) nor with the difference between post- and pre-shift urinary hippuric acid (Spearman's rho = 0.089, p = 0.847) in depot operational workers. Gasoline loading operators are exposed to a relatively high level of benzene.

Low-Cost Propellant Launch From a Tethered Balloon

NASA Technical Reports Server (NTRS)

Wilcox, Brian

2006-01-01

A document presents a concept for relatively inexpensive delivery of propellant to a large fuel depot in low orbit around the Earth, for use in rockets destined for higher orbits, the Moon, and for remote planets. The propellant is expected to be at least 85 percent of the mass needed in low Earth orbit to support the NASA Exploration Vision. The concept calls for the use of many small ( 10 ton) spin-stabilized, multistage, solid-fuel rockets to each deliver 250 kg of propellant. Each rocket would be winched up to a balloon tethered above most of the atmospheric mass (optimal altitude 26 2 km). There, the rocket would be aimed slightly above the horizon, spun, dropped, and fired at a time chosen so that the rocket would arrive in orbit near the depot. Small thrusters on the payload (powered, for example, by boil-off gases from cryogenic propellants that make up the payload) would precess the spinning rocket, using data from a low-cost inertial sensor to correct for small aerodynamic and solid rocket nozzle misalignment torques on the spinning rocket; would manage the angle of attack and the final orbit insertion burn; and would be fired on command from the depot in response to observations of the trajectory of the payload so as to make small corrections to bring the payload into a rendezvous orbit and despin it for capture by the depot. The system is low-cost because the small rockets can be mass-produced using the same techniques as those to produce automobiles and low-cost munitions, and one or more can be launched from a U.S. territory on the equator (Baker or Jarvis Islands in the mid-Pacific) to the fuel depot on each orbit (every 90 minutes, e.g., any multiple of 6,000 per year).

EQUIFAT: A novel scoring system for the semi-quantitative evaluation of regional adipose tissues in Equidae

PubMed Central

Morrison, Philippa K.; Harris, Patricia A.; Maltin, Charlotte A.; Grove-White, Dai; Argo, Caroline McG.

2017-01-01

Anatomically distinct adipose tissues represent variable risks to metabolic health in man and some other mammals. Quantitative-imaging of internal adipose depots is problematic in large animals and associations between regional adiposity and health are poorly understood. This study aimed to develop and test a semi-quantitative system (EQUIFAT) which could be applied to regional adipose tissues. Anatomically-defined, photographic images of adipose depots (omental, mesenteric, epicardial, rump) were collected from 38 animals immediately post-mortem. Images were ranked and depot-specific descriptors were developed (1 = no fat visible; 5 = excessive fat present). Nuchal-crest and ventro-abdominal-retroperitoneal adipose depot depths (cm) were transformed to categorical 5 point scores. The repeatability and reliability of EQUIFAT was independently tested by 24 observers. When half scores were permitted, inter-observer agreement was substantial (average κw: mesenteric, 0.79; omental, 0.79; rump 0.61) or moderate (average κw; epicardial, 0.60). Intra-observer repeatability was tested by 8 observers on 2 occasions. Kappa analysis indicated perfect (omental and mesenteric) and substantial agreement (epicardial and rump) between attempts. A further 207 animals were evaluated ante-mortem (age, height, breed-type, gender, body condition score [BCS]) and again immediately post-mortem (EQUIFAT scores, carcass weight). Multivariable, random effect linear regression models were fitted (breed as random effect; BCS as outcome variable). Only height, carcass weight, omental and retroperitoneal EQUIFAT scores remained as explanatory variables in the final model. The EQUIFAT scores developed here demonstrate clear functional differences between regional adipose depots and future studies could be directed towards describing associations between adiposity and disease risk in surgical and post-mortem situations. PMID:28296956

Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity.

PubMed

Lee, Mi-Jeong; Pramyothin, Pornpoj; Karastergiou, Kalypso; Fried, Susan K

2014-03-01

Central obesity is associated with insulin resistance and dyslipidemia. Thus, the mechanisms that control fat distribution and its impact on systemic metabolism have importance for understanding the risk for diabetes and cardiovascular disease. Hypercortisolemia at the systemic (Cushing's syndrome) or local levels (due to adipose-specific overproduction via 11β-hydroxysteroid dehydrogenase 1) results in the preferential expansion of central, especially visceral fat depots. At the same time, peripheral subcutaneous depots can become depleted. The biochemical and molecular mechanisms underlying the depot-specific actions of glucocorticoids (GCs) on adipose tissue function remain poorly understood. GCs exert pleiotropic effects on adipocyte metabolic, endocrine and immune functions, and dampen adipose tissue inflammation. GCs also regulate multiple steps in the process of adipogenesis. Acting synergistically with insulin, GCs increase the expression of numerous genes involved in fat deposition. Variable effects of GC on lipolysis are reported, and GC can improve or impair insulin action depending on the experimental conditions. Thus, the net effect of GC on fat storage appears to depend on the physiologic context. The preferential effects of GC on visceral adipose tissue have been linked to higher cortisol production and glucocorticoid receptor expression, but the molecular details of the depot-dependent actions of GCs are only beginning to be understood. In addition, increasing evidence underlines the importance of circadian variations in GCs in relationship to the timing of meals for determining their anabolic actions on the adipocyte. In summary, although the molecular mechanisms remain to be fully elucidated, there is increasing evidence that GCs have multiple, depot-dependent effects on adipocyte gene expression and metabolism that promote central fat deposition. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. Copyright © 2013 Elsevier B.V. All rights reserved.

Counting the costs: Comparing depot medroxyprogesterone acetate and norethisterone oenanthate utilisation patterns in South Africa

PubMed Central

2001-01-01

Background In South Africa, where health care resources are limited, it is important to ensure that drugs provision and use is rational. The Essential Drug List includes depot medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NET-EN) as injectable progestagen-only contraceptives (IPCs), and both products are extensively used. Objectives and Methods Utilisation patterns of the injectable contraceptive products DMPA and NET-EN are compared in the context of current knowledge of the safety and efficacy of these agents. Utilisation patterns were analysed by means of a Pareto (ABC) analysis of IPCs issued from 4 South African provincial pharmaceutical depots over 3 financial years. A case study from rural KwaZulu-Natal, South Africa, is used to examine utilisation patterns and self-reported side effects experienced by 187 women using IPCs. Results IPCs accounted for a substantial share of total state expenditure on drugs. While more DMPA than NET-EN was issued, NET-EN distribution from 2 depots increased over the 3-year period. Since DMPA was cheaper, if all NET-EN clients in the 1999/2000 financial year (annualised) had used DMPA, the 4 depots could have saved 4.95 million South African Rands on product acquisition costs alone. The KZN case study showed slightly more NET-EN (54%) than DMPA (46%) use; no significant differences in self-reported side effects; and that younger women were more likely to use NET-EN than DMPA (p = 0.0001). Conclusions Providing IPCs on the basis of age is not appropriate or cost effective. Rational use of these products should include consideration of the cost of prescribing one over another. PMID:11401729

Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: CENTRAL Magnetic Resonance Imaging Randomized Controlled Trial.

PubMed

Gepner, Yftach; Shelef, Ilan; Schwarzfuchs, Dan; Zelicha, Hila; Tene, Lilac; Yaskolka Meir, Anat; Tsaban, Gal; Cohen, Noa; Bril, Nitzan; Rein, Michal; Serfaty, Dana; Kenigsbuch, Shira; Komy, Oded; Wolak, Arik; Chassidim, Yoash; Golan, Rachel; Avni-Hassid, Hila; Bilitzky, Avital; Sarusi, Benjamin; Goshen, Eyal; Shemesh, Elad; Henkin, Yaakov; Stumvoll, Michael; Blüher, Matthias; Thiery, Joachim; Ceglarek, Uta; Rudich, Assaf; Stampfer, Meir J; Shai, Iris

2018-03-13

We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. We performed an 18-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to isocaloric low-fat or Mediterranean/low-carbohydrate (MED/LC) diet+28 g walnuts/day with/without added moderate physical activity (PA; 80% aerobic; supervised/free gym membership). Overall primary outcome was body fat redistribution, and the main specific end point was visceral adipose tissue (VAT). We further followed the dynamics of different fat depots (deep and superficial subcutaneous, liver, pericardial, muscle, pancreas, and renal sinus) by magnetic resonance imaging. Of 278 participants (age, 48 years, 89% men, body mass index, 30.8 kg/m 2 ), 86% completed the trial with good adherence. The low-fat group preferentially decreased reported fat intake (-21.0% versus -11.5% for the MED/LC; P <0.001), and the MED/LC group decreased reported carbohydrates intake (-39.5% versus -21.3% for the low-fat group; P <0.001). The PA + groups significantly increased the metabolic equivalents per week versus the PA - groups (19.0 versus 2.1; P =0.009). Whereas final moderate weight loss was indifferent, exercise attenuated the waist circumference rebound with the greatest effect in the MED/LC PA+ group ( P <0.05). VAT (-22%), intrahepatic (-29%), and intrapericardial (-11%) fats declines were higher than pancreatic and femur intermuscular fats (1% to 2%) loss. Independent of weight loss, PA + with either diet had a significantly greater effect on decreasing VAT (mean of difference, -6.67cm 2 ; 95% confidence interval, -14.8 to -0.45) compared with PA - . The MED/LC diet was superior to the low-fat diet in decreasing intrahepatic, intrapericardial, and pancreatic fats ( P <0.05 for all). In contrast, renal sinus and femoral intermuscular fats were not differentially altered by lifestyle interventions but by weight loss per se. In multivariate models further adjusted for weight loss, losing VAT or intrahepatic fat was independently associated with improved lipid profile, losing deep subcutaneous adipose tissue with improved insulin sensitivity, and losing superficial subcutaneous adipose tissue remained neutral except for an association with decreased leptin. Moderate weight loss alone inadequately reflects the significant lifestyle effects on atherogenic and diabetogenic fat depots. The MED/LC diet mobilizes specific ectopic fat depots, and exercise has an independent contribution to VAT loss. Fat depots exhibit diverse responsiveness and are differentially related to cardiometabolic markers. Distinct lifestyle protocols may uniquely induce fat mobilization from specific anatomic sites. URL: https://www.clinicaltrials.gov. Unique identifier: NCT01530724. © 2017 American Heart Association, Inc.

Nandrolone decanoate and physical activity affect quadriceps in peripubertal rats.

PubMed

Sretenovic, Jasmina; Ajdzanovic, Vladimir; Zivkovic, Vladimir; Srejovic, Ivan; Corbic, Milena; Milosevic, Verica; Jakovljevic, Vladimir; Milosavljevic, Zoran

2018-07-01

Anabolic androgenic steroids (AASs) are synthetic analogs of testosterone often used by athletes to increase the skeletal muscle mass. Our goal was to examine the effects of physical activity and physical activity combined with supraphysiological doses of nandrolone on functional morphology of the quadriceps muscle. The study included 32 peripubertal Wistar rats, divided into 4 groups: control (T-N-), nandrolone (T-N+), physical activity (T+N-) and physical activity plus nandrolone (T+N+) groups. The T+N- and T+N+ group swam for 4 weeks, 1 h/day, 5 days/week. The T-N+ and T+N+ groups received nandolone decanoate (20 mg/kg b.w.) once per week, subcutaneously. Subsequently, the rats were sacrificed and muscle specimens were prepared for the processing. Tissue sections were histochemically and immunohistochemically stained, while the image analysis was used for quantification. Longitudinal diameter of quadriceps muscle cells was increased for 21% in T-N+, for 57% in T+N- and for 64% in T+N+ group while cross section muscle cell area was increased in T-N+ for 19%, in T+N- for 47% and in T+N+ group for 59%, compared to the control. Collagen fibers covered area was increased in T-N+ group for 36%, in T+N- for 109% and in T+N+ group for 159%, compared to the control. Erythrocyte depots were decreased in T-N+ group and increased in T+N- and T+N+ group, in comparison with T-N-. VEGF depots were increased in all treated groups. Chronic administration of supraphysiological doses of AASs alone or in combination with physical activity induces hypertrophy and significant changes in the quadriceps muscle tissue structure. Copyright © 2018 Elsevier GmbH. All rights reserved.

Identification and Quantification of Hydrocarbon Products in Effluents.

DTIC Science & Technology

1980-05-01

Tobyhanna Army Depot ATTN: Const. Mgmt. Br. Jacksonville Tooele Army Depot ATTN: Engr. Library Japan Watervliet Arsenal Jidda Yuma Proving Ground Chief...the prepared standard series were stored in volumetric flasks sealed with latex caps over ground glass stoppers. Absorption spectra of the standa-rds in...Facilities Engineer Walter Reed Army Medical Center ATTN: DAEN-CW ARRADCOM ATIN: DAEN-RM Aberdeen Proving Ground USACC ATTN: DAEN-CCP Army Matis. and Mechanics

Formative Evaluation of a Sociotechnical System Intervention at an Army Maintenance Depot

DTIC Science & Technology

1986-07-01

periodically reassess itself to determine if the balance between the technical and social systems remains adaptive and responsive to the requirements...developed a comprehensive set of recommendations for improving the balance between the social and technical systems of the depot. During 1983, most of...ity and quality of worklife . However, the nature and extent of the impact is highly elusive and resistant to quantification. 1-4 FORMATIVE

Department of Defense Logistics Roadmap 2008. Volume 2

DTIC Science & Technology

2008-07-01

endeavors to better synchronize field and depot maintenance data systems resulting in faster Programmed Depot Maintenance (PDM) completion. The...mechanic-centric”. This will put the mechanic actually on the aircraft more often, with the tools and resources to complete their tasks, resulting in...MAJCOM’s: 1. Status to target 2. Initiatives 3. Results FY07 Level: FY10 Target: Goal: The five desired effects of AFSO21 are to: 1. Increased

Identification of Relevant Costs in the Decision to Consolidate or Maintain Two Marine Corps Recruit Training Depots

DTIC Science & Technology

2015-06-01

Martial Arts Program MCRD Marine Corps Recruit Depot PCO Property Control Office PSC permanent change of station PSE personnel support...office supplies and materials required for the operations office to function. The Property Control Office ( PCO ) is another cost under the base...operations subcategory. PCO supports the Marines with non-deployable equipment. PCO Garrison Property, PSE, collateral equipment (CE) and food preparation

Superfund record of decision (EPA Region 3): Letterkenny Army Depot (PDO and SE Areas), Chambersburg, Franklin County, PA, September 30, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-11-01

The decision document presents the selected remedial action for the Phase 1 Parcels at Letterkenny Army Depot (LEAD), Chambersburg, Pennsylvania. Based on consideration of he CERCLA requirements, the NCP, the detailed analysis of the alternatives using the nine criteria, and public and state comments, the Army and EPA have selected an institutional controls remedy for this Site.

The Home Depot Upgrades its Corporate Building Prototype

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2013-03-01

The Home Depot partnered with the Department of Energy (DOE) to develop and implement solutions to build new, low-energy buildings that are at least 50% below Standard 90.1-2007 of the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE), the American National Standards Institute (ANSI), and the Illuminating Engineering Society of North America (IESNA) as part of DOE’s Commercial Building Partnerships (CBP) Program.

Defense Inventory: Further Analysis and Enhanced Metrics Could Improve Service Supply and Depot Operations

DTIC Science & Technology

2016-06-01

of and replace. DOD maintains weapon systems (e.g., aircraft and ships) and equipment (e.g., generators and radars) that require regular and...including helicopters, combat vehicles, air defense systems, ships, fighter and bomber aircraft , intercontinental ballistic missiles, jet aircraft ...Defense for Acquisition, Technology, and Logistics. 19In the depot maintenance context, an end item can be a weapon system, such as an aircraft , ship

Enabling Early Sustainment Decisions: Application to F-35 Depot-Level Maintenance

DTIC Science & Technology

2013-01-01

Level Maintenance John G. Drew, Ronald G. McGarvey, Peter Buryk Research Report Enabling Early Sustainment Decisions Application to F-35 Depot-Level...Maintenance John G. Drew, Ronald G. McGarvey, Peter Buryk RAND Project AIR FORCE Prepared for the United States Air Force Approved for public...Related publications include the following: John Drew, Russell D. Shaver, Kristin F. Lynch, Mahyar A. Amouzegar, and Don Snyder, Unmanned Aerial

UXO Detection and Characterization in the Marine Environment

DTIC Science & Technology

2009-12-01

10 Figure 8. A part of Ostrich Bay adjacent to the Naval Ammunition Depot Puget Sound during the period of its...large-scale demonstration focus on a marine geophysical magnetometry survey of Ostrich Bay adjacent to the Former Naval Ammunition Depot – Puget Sound ...The Puget Sound Demonstration was also supported by NAVFAC Northwest, the current manager of the site. The Navy Project Manager is Mr. Mark Murphy

Process and Energy Optimization Assessment, Tobyhanna Army Depot, PA

DTIC Science & Technology

2006-04-17

assembly of electronic-communication components, different welding processes are performed at TYAD. It uses shielded arc, metal inert gas (MIG...tungsten inert gas ( TIG ), and silver braz- ing oxygen/acetylene cutting plasma arc methods to complete mission re- quirements. Major welding jobs are...ER D C/ CE R L TR -0 6 -1 1 Process and Energy Optimization Assessment Tobyhanna Army Depot, PA Mike C.J. Lin, Alexander M. Zhivov

Two-dimensional direct-current resistivity survey to supplement borehole data in ground-water models of the former Blaine Naval Ammunition Depot, Hastings, Nebraska, September 2003

USGS Publications Warehouse

Kress, Wade H.; Ball, Lyndsay B.; Teeple, Andrew; Turco, Michael J.

2006-01-01

The former Blaine Naval Ammunition Depot located immediately southeast of Hastings, Nebraska, was an ammunition facility during World War II and the Korean Conflict. Waste-management practices during operation and decommissioning of the former Depot resulted in soil and ground-water contamination. Ground-water models have been used by the U.S. Army Corps of Engineers to provide information on the fate and transport of contaminants on the former Depot site. During September 2003, the U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, Kansas City District, conducted a pilot study to collect two-dimensional direct-current resistivity data on the site along six profiles near existing monitoring wells. The inversion results of field data from five of the six two-dimensional direct-current resistivity profiles display distinct electrical stratigraphy consistent with three resistivity units (low resistivity, high resistivity, and low resistivity). These three resistivity units correlate with rock-stratigraphic or hydrogeologic units described prior to this study. To interpret the resistivity profiles, additional data extending through the lower confining unit into the underlying Niobrara Formation could be used with the existing data to construct forward models for data analysis and interpretation.

Reproducible MRI Measurement of Adipose Tissue Volumes in Genetic and Dietary Rodent Obesity Models

PubMed Central

Johnson, David H.; Flask, Chris A.; Ernsberger, Paul R.; Wong, Wilbur C. K.; Wilson, David L.

2010-01-01

Purpose To develop ratio MRI [lipid/(lipid+water)] methods for assessing lipid depots and compare measurement variability to biological differences in lean controls (spontaneously hypertensive rats, SHRs), dietary obese (SHR-DO), and genetic/dietary obese (SHROBs) animals. Materials and Methods Images with and without CHESS water-suppression were processed using a semi-automatic method accounting for relaxometry, chemical shift, receive coil sensitivity, and partial volume. Results Partial volume correction improved results by 10–15%. Over six operators, volume variation was reduced to 1.9 ml from 30.6 ml for single-image-analysis with intensity inhomogeneity. For three acquisitions on the same animal, volume reproducibility was <1%. SHROBs had 6X visceral and 8X subcutaneous adipose tissue than SHRs. SHR-DOs had enlarged visceral depots (3X SHRs). SHROB had significantly more subcutaneous adipose tissue, indicating a strong genetic component to this fat depot. Liver ratios in SHR-DO and SHROB were higher than SHR, indicating elevated fat content. Among SHROBs, evidence suggested a phenotype SHROB* having elevated liver ratios and visceral adipose tissue volumes. Conclusion Effects of diet and genetics on obesity were significantly larger than variations due to image acquisition and analysis, indicating that these methods can be used to assess accumulation/depletion of lipid depots in animal models of obesity. PMID:18821617

Fundamental understanding of drug absorption from a parenteral oil depot.

PubMed

Kalicharan, Raween W; Schot, Peter; Vromans, Herman

2016-02-15

Oil depots are parenteral drug formulations meant for sustained release of lipophilic compounds. Until now, a comprehensive understanding of the mechanism of drug absorption from oil depots is lacking. The aim of this paper was to fill this gap. A clinical study with healthy volunteers was conducted. An oil depot with nandrolone decanoate and benzyl alcohol was subcutaneously administered in the upper arm of female volunteers. Pharmacokinetic profiles of both substances were related to each other and to literature data. Benzyl alcohol absorbs much more rapidly than nandrolone. In detail, it appears that benzyl alcohol enters the central compartment directly, while nandrolone decanoate is recovered in serum after a lag time. This lag time is also seen in literature data, although not reported explicitly. The absorption of nandrolone is enhanced by the presence of benzyl alcohol. This is most likely an effect of altered oil viscosity and partition coefficient between the oil and aqueous phase. The absorption rate constant of compounds is found to be related to the logP of the solubilized prodrug. The absorption rate is however not only determined by the physico-chemical properties of the formulation but also by the tissue properties. Here, it is argued that lymphatic flow must be considered as a relevant parameter. Copyright © 2015 Elsevier B.V. All rights reserved.

[NUTRITIONAL STATUS IN THE EXPERIMENT WITH 105-DAY ISOLATION AS THE FIRST PHASE OF PROJECT MARS-500].

PubMed

Agureev, A N; Afonin, B V; Sedova, E A; Solovieva, A A; Valuev, V A; Sidorenko, L A

2015-01-01

In a 105-day experiment simulating crew life in a space exploration vehicle, shifts in the nutritional status were assessed in 6 test subjects differing in the body mass index, basal metabolism, attitude to the diet, physical exercise and workload. Results of the investigation showed that because of the hard physical work the nutritional status of test subjects was described by more intensive basal metabolism, elevated metabolism of carbohydrates and lipids, and their increased mobilization from depots. Food ration, though it was sufficient to sustain health and fairly high performance, failed to meet fully individual taste preferences and energy needs for physical activities. The heavy workloads required mobilization of lipids from adipose depots, and a decrease of the hepatic detoxification and metabolic capacities. Self-limitation of eating protein-rich desserts led to a relative deficiency of protein intake. These faults of the diet were the reason why 4 out of 6 test subjects reduced their basal metabolism and lost body mass. Recovery of metabolism and slowdown of the body mass loss were achieved by supplementing meals with available protein-containing products.

LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

PubMed

Loh, Nellie Y; Neville, Matt J; Marinou, Kyriakoula; Hardcastle, Sarah A; Fielding, Barbara A; Duncan, Emma L; McCarthy, Mark I; Tobias, Jonathan H; Gregson, Celia L; Karpe, Fredrik; Christodoulides, Constantinos

2015-02-03

Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human adipose tissue. Subjects with gain-of-function LRP5 mutations and high bone mass had enhanced lower-body fat accumulation. Reciprocally, a low bone mineral density-associated common LRP5 allele correlated with increased abdominal adiposity. Ex vivo LRP5 expression was higher in abdominal versus gluteal adipocyte progenitors. Equivalent knockdown of LRP5 in both progenitor types dose-dependently impaired β-catenin signaling and led to distinct biological outcomes: diminished gluteal and enhanced abdominal adipogenesis. These data highlight how depot differences in WNT/β-catenin pathway activity modulate human fat distribution via effects on adipocyte progenitor biology. They also identify LRP5 as a potential pharmacologic target for the treatment of cardiometabolic disorders. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

PubMed Central

Loh, Nellie Y.; Neville, Matt J.; Marinou, Kyriakoula; Hardcastle, Sarah A.; Fielding, Barbara A.; Duncan, Emma L.; McCarthy, Mark I.; Tobias, Jonathan H.; Gregson, Celia L.; Karpe, Fredrik; Christodoulides, Constantinos

2015-01-01

Summary Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human adipose tissue. Subjects with gain-of-function LRP5 mutations and high bone mass had enhanced lower-body fat accumulation. Reciprocally, a low bone mineral density-associated common LRP5 allele correlated with increased abdominal adiposity. Ex vivo LRP5 expression was higher in abdominal versus gluteal adipocyte progenitors. Equivalent knockdown of LRP5 in both progenitor types dose-dependently impaired β-catenin signaling and led to distinct biological outcomes: diminished gluteal and enhanced abdominal adipogenesis. These data highlight how depot differences in WNT/β-catenin pathway activity modulate human fat distribution via effects on adipocyte progenitor biology. They also identify LRP5 as a potential pharmacologic target for the treatment of cardiometabolic disorders. PMID:25651180

The role of remotely sensed and other special data for predictive modeling: the Umatilla, Oregon example

USGS Publications Warehouse

Loveland, Thomas R.; Johnson, Gary E.

1983-01-01

Landsat data and 1:24 000-scale aerial photographs were initially used to map the expansion of irrigation from 1973 to 1979 and to identify crops under irrigation in 1979. The crop data were then used with historical water requirement figures and digital topographic and hydrographic data to estimate water and power use for the 1979 irrigation season. The final project task involved production of a composite map of land suitability for irrigation development based on land cover (from Landsat), landownership, soil irrigability, slope gradient, and potential energy costs.

Enhanced Preliminary Assessment Report: Navajo Depot Activity, Bellemont, Arizona

DTIC Science & Technology

1990-03-01

short-term storage of conventional munitions being moved in and out of the Igloo Areas. 3 3.3.2 Chemical Agents Mustard (H)-filled M-78 bombs were stored ...Aberdeen Proving Ground Maryland 21010-5401 * Prepared by: Ebasco Environmental 143 Union Blvd., Suite 1010 Lakewood, Colorado 80228 MMUTION STXTUEIT...Materials Agency Aberdeen Proving Ground Maryland 2101 0-5401 IPrepared by: * EBACO Ebasco Environmental 143 Union Blvd., Suite 1010 i Lakewood, Colorado

The Importance of Submarine Tenders to a Modern Naval War: Naval Combat Logistics and Seabasing

DTIC Science & Technology

2017-04-28

projected ship maintenance depots, and the time required for ships to travel back to US based facilities presents major operational consequences to...hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and...Department of the Navy. 14. ABSTRACT The potential for the US Navy’s adversaries to target its forward-projected ship maintenance depots, and the time

East Europe Report, Economic and Industrial Affairs, Number 2425.

DTIC Science & Technology

1983-07-21

the proper tightening of turn buckles, and proper quality repairs and maintenance of car traction systems in car depots and railroad plants . The...Improve the quality of planned engine repairs in depots and repair plants . In 1982 a damaged railroad car has had to be uncoupled in...tons) were applied. The tests were conducted on the press of the G. Dimitrov ZhPZ [Railroad Plant ] in Sofia. Table 1 shows the dependence between

Successful Hazwaste Program Halts Annual State Inspection

DTIC Science & Technology

2011-05-01

ES) Red River Army Depot ,100 James Carlow Drive, Texarkana ,TX,75507-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY...MAIN DRIVE. TEXARKANA . lX 75507 ~5000103 334~3333 Accumulation Start Date ** Cert1fied F1ll Date. WC$0oocr- IIFiol ----= CUSTOMIZE YOUR OWN...MARKING/LABELING TO COMPLY BE AMERICA’S BEST Con tamer: *RRA0023678* RRAD023678 Hazardous Waste RED RIVER ARMY DEPOT 100 MAIN DRIVE TEXARKANA , 1X

The Effect of Soil Properties on Metal Bioavailability: Field Scale Validation to Support Regulatory Acceptance

DTIC Science & Technology

2014-06-01

unacceptable levels of the toxic metal(loid)s arsenic (As), cadmium (Cd), chromium (Cr), and lead (Pb). With the exception of Pb contaminated soils, human...remediation and closure. Lead (Pb), arsenic (As), chromium (Cr), and cadmium (Cd) are toxic (i.e., capable of producing an unwanted, deleterious effect...lagoon are contaminated with high concentrations of lead , chromium, and cadmium . 14 Deseret Chemical Depot: The Deseret Chemical Depot is

Depot Maintenance: Actions Needed to Identify and Establish Core Capability at Military Depots

DTIC Science & Technology

2009-05-01

and the original equipment manufacturer is still repairing the equipment. • The Navy’s Advanced Tactical Air Reconnaissance System ( ATARS ), which...radar sensor data and control a data-link subsystem for real-time and near-real-time transmission. Although ATARS was determined to have core...systems and the unique tools needed for the complex repairs. Thus, funding to establish core capabilities for ATARS has been requested by the

Infrared Thermal Testing Of Mechanical Assemblies At The Military Depot And Field Level: A Progress Report

NASA Astrophysics Data System (ADS)

Kaplan, Herbert

1988-01-01

Based on encouraging results on the Army's programs for infrared mass screening of printed circuit boards at the depot level, the US Army CECOM (Communication-Electronics Command) undertook a one-year investigation of the applicability of similar techniques to screening and diagnostics of mechanical assemblies. These included tanks, helicopters, transport vehicles and their major subassemblies (transmissions, engines, axles, etc.) at field and depot levels. Honeyhill Technical Company was tasked to classify candidate assemblies and perform preliminary measurements using Army-owned general-purpose thermal imaging equipment. The investigations yielded positive results, and it was decided to pursue a comprehensive measurements program using field-mobile equipment specifically procured for the program. This paper summarizes the results of the investigations, outlines the measurements techniques utilized, describes the classification and selection of candidate assemblies, and reports on progress toward the goals of the program.

Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery

PubMed Central

Petersen, Latrisha K; Huntimer, Lucas; Walz, Katharine; Ramer-Tait, Amanda; Wannemuehler, Michael J; Narasimhan, Balaji

2013-01-01

Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry- and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants. PMID:23818778

Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery.

PubMed

Petersen, Latrisha K; Huntimer, Lucas; Walz, Katharine; Ramer-Tait, Amanda; Wannemuehler, Michael J; Narasimhan, Balaji

2013-01-01

Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tissue. In this work, we designed a combinatorial platform to investigate the in vivo distribution, depot effect, and localized persistence of polyanhydride nanoparticles as a function of nanoparticle chemistry and administration route. Our observations indicated that the route of administration differentially affected tissue residence times. All nanoparticles rapidly dispersed when delivered intranasally but provided a depot when administered parenterally. When amphiphilic and hydrophobic nanoparticles were administered intranasally, they persisted within lung tissue. These results provide insights into the chemistry- and route-dependent distribution and tissue-specific association of polyanhydride nanoparticle-based vaccine adjuvants.

Public health assessment for USMC Marine Corps Recruit Depot (a/k/a Parris Island Marine Corps Recruit Depot), Parris Island, Beaufort County, South Carolina, Region 4. Cerclis No. SC6170022762

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-09-12

Marine Corps Recruit Depot, (MCRD) Parris Island was proposed for listing on U.S. Environmental Protection Agency`s National Priorities List in August 1994. We identified two areas where chemical contaminants in soil entered the surface water wetland areas and bioaccumulated in edible fish and shellfish species: (1) contaminated fish and shellfish at the Causeway Landfill (Site 3) and (2) contaminated shellfish near the Rifle Range. These exposure situations pose no apparent public health hazard due to the low levels of contaminants detected in fish and shellfish. However, because the landfill has no impermeable cap nor leachate collection system, it is notmore » known whether contaminants in fish and shellfish will increase over time. The remaining 57 contaminated areas pose no public health hazard because people are not coming in contact with contaminants.« less

Data Storage and sharing for the long tail of science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, B.; Pouchard, L.; Smith, P. M.

Research data infrastructure such as storage must now accommodate new requirements resulting from trends in research data management that require researchers to store their data for the long term and make it available to other researchers. We propose Data Depot, a system and service that provides capabilities for shared space within a group, shared applications, flexible access patterns and ease of transfer at Purdue University. We evaluate Depot as a solution for storing and sharing multiterabytes of data produced in the long tail of science with a use case in soundscape ecology studies from the Human- Environment Modeling and Analysismore » Laboratory. We observe that with the capabilities enabled by Data Depot, researchers can easily deploy fine-grained data access control, manage data transfer and sharing, as well as integrate their workflows into a High Performance Computing environment.« less

Public health assessment addendum for Letterkenny Army Depot, USA Letterkenny Southeast Area, Chambersburg, Franklin County, Pennsylvania, Region 3. CERCLIS No. PA6213820503 and USA Letterkenny, Property Disposal Office Area, Chambersburg, Franklin County, Pennsylvania. CERCLIS No. PA2210090054. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-05-25

The Letterkenny Army Depot (Letterkenny) is five miles north of Chambersburg, in Franklin County, Pennsylvania. The US Army Depot consists of two National Priorities List (NPL) sites: USA Letterkenny Southeast Area (hereafter referred to as the SE Area) and USA Letterkenny - Property Disposal Office Area (hereafter referred to as the PDO Area). A public health assessment of those combined sites was released by the Agency for Toxic Substances and Disease Registry on September 30, 1988 (Appendix 1). The previous public health assessment combined discussion of both NPL sites due to similar contaminants and pathways. Since the release of themore » previous public health assessment, new environmental, community health concerns, and health outcome data have become available, warranting this addendum.« less

Utilizing Solar Power Technologies for On-Orbit Propellant Production

NASA Technical Reports Server (NTRS)

Fikes, John C.; Howell, Joe T.; Henley, Mark W.

2006-01-01

The cost of access to space beyond low Earth orbit may be reduced if vehicles can refuel in orbit. The cost of access to low Earth orbit may also be reduced by launching oxygen and hydrogen propellants in the form of water. To achieve this reduction in costs of access to low Earth orbit and beyond, a propellant depot is considered that electrolyzes water in orbit, then condenses and stores cryogenic oxygen and hydrogen. Power requirements for such a depot require Solar Power Satellite technologies. A propellant depot utilizing solar power technologies is discussed in this paper. The depot will be deployed in a 400 km circular equatorial orbit. It receives tanks of water launched into a lower orbit from Earth, converts the water to liquid hydrogen and oxygen, and stores up to 500 metric tons of cryogenic propellants. This requires a power system that is comparable to a large Solar Power Satellite capable of several 100 kW of energy. Power is supplied by a pair of solar arrays mounted perpendicular to the orbital plane, which rotates once per orbit to track the Sun. The majority of the power is used to run the electrolysis system. Thermal control is maintained by body-mounted radiators; these also provide some shielding against orbital debris. The propellant stored in the depot can support transportation from low Earth orbit to geostationary Earth orbit, the Moon, LaGrange points, Mars, etc. Emphasis is placed on the Water-Ice to Cryogen propellant production facility. A very high power system is required for cracking (electrolyzing) the water and condensing and refrigerating the resulting oxygen and hydrogen. For a propellant production rate of 500 metric tons (1,100,000 pounds) per year, an average electrical power supply of 100 s of kW is required. To make the most efficient use of space solar power, electrolysis is performed only during the portion of the orbit that the Depot is in sunlight, so roughly twice this power level is needed for operations in sunlight (slightly over half of the time). This power level mandates large solar arrays, using advanced Space Solar Power technology. A significant amount of the power has to be dissipated as heat, through large radiators. This paper briefly describes the propellant production facility and the requirements for a high power system capability. The Solar Power technologies required for such an endeavor are discussed.

The effect of financial incentives on patients' motivation for treatment: results of "Money for Medication," a randomised controlled trial.

PubMed

Noordraven, Ernst L; Wierdsma, André I; Blanken, Peter; Bloemendaal, Anthony F T; Mulder, Cornelis L

2018-05-24

Offering financial incentives is an effective intervention for improving adherence in patients taking antipsychotic depot medication. We assessed whether patients' motivation for treatment might be reduced after receiving financial rewards. This study was part of Money for Medication, a multicentre, open-label, randomised controlled trial, which demonstrated the positive effects of financial incentives on antipsychotic depot compliance. Three mental healthcare institutions in Dutch secondary psychiatric care services participated. Eligible patients were aged 18-65 years, had been diagnosed with schizophrenia or another psychotic disorder, had been prescribed antipsychotic depot medication or had an indication to start using depot medication, and were participating in outpatient treatment. For 12 months, patients were randomly assigned either to treatment as usual (control group) or to treatment as usual plus a financial reward for each depot of medication received (€30 per month if fully compliant; intervention group). They were followed up for 6 months, during which time no monetary rewards were offered for taking antipsychotic medication. To assess treatment motivation after 0, 12 and 18 months, interviews were conducted using a supplement to the Health of the Nation Outcome Scales (HoNOS) and the Treatment Entry Questionnaire (TEQ). Patients were randomly assigned to the intervention (n = 84) or the control group (n = 85). After 12 months, HoNOS motivation scores were available for 131 patients (78%). Ninety-one percent of the patients had no or mild motivational problems for overall treatment; over time, there were no significant differences between the intervention and control groups. TEQ data was available for a subgroup of patients (n = 61), and showed no significant differences over time between the intervention and control groups for external motivation (β = 0.37 95% CI: -2.49 - 3.23, p = 0.799); introjected motivation (β = - 2.39 95% CI: -6.22 - 1.44, p = 0.222); and identified motivation (β = - 0.91 95% CI: -4.42 - 2.61, p = 0.613). After the 6-month follow-up period, results for the HoNOS and TEQ scores remained comparable. Offering financial incentives for taking antipsychotic depot medication does not reduce patients' motivation for treatment. Netherlands Trial registration, number NTR2350 .

Assessment of occupational exposure to polycyclic aromatic hydrocarbons via involuntary ingestion of soil from contaminated soils in Lagos, Nigeria.

PubMed

Adetunde, Oluwatoyin T; Mills, Graham A; Olayinka, Kehinde O; Alo, Babajide I

2014-01-01

Soils from 12 sites in Lagos area, Nigeria impacted by anthropogenic activities were extracted by ultrasonication and analysed for the concentration of 16 priority polycyclic aromatic hydrocarbons (PAHs) by gas chromatograph-mass spectrometer (GC-MS). The concentration of the sum of PAHs ranged from 0.2 to 254 μg/g at these sites. The sum benzo[a]pyrene-equivalent dose (BaPeq) at the sites ranged from 0.0 (K, forest soil) to 16.7 μg/g (C, the lubricating oil depot soil). Mean daily intake (MDI) for the composite soils samples when compared that of food revealed that some of the individual PAH in samples from sites A (Dump site), C (Depot and loading point for used for black oil), F (Dump site), G(petroleum depot), H (Roadside) and L (Car park) exceeded the recommended the recommended MDI threshold for food, indicating some risk associated with activities on these sites based on this ingestion estimate exceeded value. 8.2 × 10(-6), 7.1 × 10(-7), 1.2 × 10(-4), 4.9 × 10(-7), 7.3 × 10(-7), 1.4 × 10(-5), 7.9 × 10(-5), 4.6 × 10(-6), 3.4 × 10(-7), 2.4 × 10(-7), 2.2 × 10(-7) and 1.1 × 10(-4) estimated theoretical cancer risk (ER) for an adult with a body weight of 70 kg working on sites were composite soil samples A, B, C, D, E, F, G, H, I, J, K and L respectively were sampled. The ER from occupational exposure to surface soil based on oral ingestion were all higher than the target risk of 1 × 10(-6) for normal exposure but were all within the 1 × 10(-4) for extreme exposure for most of the sites except for site C and L. The differences in concentration and risk were related to the different activities (e.g., handling of petroleum products, open burning, bush burning) undertaken at these locations. However, it should be noted here that the resultant risk could be overestimated, since these calculations were based on an exhaustive extraction technique which may be different from uptake by the human guts (bioavailability study).

DCASR (Defense Contract Administration Services Region) Atlanta Total Quality Management (TQM) Strategic Plan

DTIC Science & Technology

1989-07-01

Form 298 (Rev. 2-89) STATEMENT OF APPRECIATION We wish to thank the following private companies and Department of Defense organizations for their...Systems Sector , P.O. Box 37, Melbourne, FL 32902 Naval Aviation Depot, Cherry Point, NC 28533-5030 Norfolk Naval Shipyard, Portsmouth, VA 23709-5000...Corporation, Government Systems Sector ; Mr. Jack Adams and Mr. Fred Davenport of the TQM Office, Naval Aviation Depot, Cherry Point; and Captain E.S

Total Quality Management Implementation Plan Defense Depot Memphis

DTIC Science & Technology

1989-07-01

W.ungilon. 0 t :0.O. )RT DATE 3. REPORT TYPE AND DATES COVERED I July 1989 _ 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Total Quality Management Implementation...improvement goals, implementation strategy and milestones. 6’ SEP 291989 /; ELECTE i= E 14. SUBJECT TERMS 15. NUMBER OF PAGES TQM (Total Quality Management ), Depot...changing work environment where change is the norm. We are talking about changes in attitudes and habits. Total Quality Management is not a panacea

Predicting Aircraft Availability

DTIC Science & Technology

2013-06-01

Table 9. Variables Used for Correlation Analysis Available ( N ) Available (%) Depot (%) UPNR ( N ) UPNR (%) TAI ( N ) MC (%) NMCB (%) NMCM (%) NMCS... Correlation Results Available Depot (%) UPNR ( N ) UPNR (%) TAI ( N ) MC (%) NMCB (%) NMCM (% NMCS (%) MMH / FH Hours FlowSorties FloSorties SchASD (H...28 Standardizing the Data………………………………………………………………..35 Correlation of

Applying the Theory of Constraints (TOC) to the Component Section of Naval Aviation Depot (NADEP), North Island

DTIC Science & Technology

1992-12-01

current repair policies and procedures within this shop. We offer some ideas and suggestions for changing and improving existing operations and the...implementing and focusing continual improvements in Shop 93302 and ultimately in the depot as a whole. 20. DISTRIBUTION/AVAILABILITY OF ABSTRACT 21...used to evaluate current repair policies and procedures within this shop. We also offer some ideas and suggestions for changing and improving existing

A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes

PubMed Central

Liu, Weiyi; Shan, Tizhong; Yang, Xin; Liang, Sandra; Zhang, Pengpeng; Liu, Yaqin; Liu, Xiaoqi; Kuang, Shihuan

2013-01-01

Summary A worldwide epidemic of obesity and its associated metabolic disorders raise the significance of adipocytes, their origins and characteristics. Our previous study has demonstrated that interscapular brown adipose tissue (BAT), but not intramuscular adipose, is derived from the Pax3-expressing cell lineage. Here, we show that various depots of subcutaneous (SAT) and visceral adipose tissue (VAT) are highly heterogeneous in the Pax3 lineage origin. Interestingly, the relative abundance of Pax3 lineage cells in SAT depots is inversely correlated to expression of BAT signature genes including Prdm16, Pgc1a (Ppargc1a) and Ucp1. FACS analysis further demonstrates that adipocytes differentiated from non-Pax3 lineage preadipocytes express higher levels of BAT and beige adipocyte signature genes compared with the Pax3 lineage adipocytes within the same depots. Although both Pax3 and non-Pax3 lineage preadipocytes can give rise to beige adipocytes, the latter contributes more significantly. Consistently, genetic ablation of Pax3 lineage cells in SAT leads to increased expression of beige cell markers. Finally, non-Pax3 lineage beige adipocytes are more responsive to cAMP-agonist-induced Ucp1 expression. Taken together, these results demonstrate widespread heterogeneity in Pax3 lineage origin, and its inverse association with BAT gene expression within and among subcutaneous adipose depots. PMID:23781029

The effect of dietary copper supplementation on fatty acid profile and oxidative stability of adipose depots in Boer x Spanish goats.

PubMed

Cummins, K A; Solaiman, S G; Bergen, W G

2008-02-01

A feeding trial was designed to examine the effects of copper sulfate pentahydrate (CuSO(4).5H(2)O) on the fatty acid composition and oxidative stability in muscle and adipose tissues of Boer x Spanish goat kids. Fifteen (n = 5 per treatment) goats were fed 0, 100, or 200 mg of supplemental Cu per day as copper sulfate for 98 d. The animals were slaughtered, and LM, s.c. adipose from the sternal region, and mesenteric adipose tissues were collected. Total lipids were extracted with chloroform:methanol (2:1), methylated and isolated via GLC from all tissues. The subsequent peaks were then positively identified by mass spectrometry. Thiobarbituric acid-reactive substances were measured also. In s.c. adipose, dietary Cu significantly decreased C14:0 (P = 0.03) and C16:0 (P = 0.01). In muscle, C15:0 (P = 0.03) was linearly increased by Cu. Dietary Cu supplementation did not influence oxidative stability in goat muscle or s.c. adipose. Copper supplementation at 200 mg/d resulted in a significant increase in malondialdehyde in mesenteric adipose (P = 0.01) compared with the 0 or 100 mg/d groups. These results indicate that lipid composition may differ from depot to depot and that depending on the depot, dietary Cu seems to elicit a variable response on the fatty acid composition.

Earth Observations taken by the Expedition 17 Crew

NASA Image and Video Library

2008-10-01

ISS017-E-018075 (1 Oct. 2008) --- The Pueblo Chemical Depot in Colorado is featured in this image photographed by an Expedition 17 crewmember on the International Space Station. This view illustrates the unusual man-made landscape of the Pueblo Chemical Depot located near the city of Pueblo, Colorado. The Depot was built during World War II by the U.S. Army to house and ship ammunition needed for war efforts, and this role transitioned to missile repair and maintenance during the Cold War with the Soviet Union. The current use of the Depot is to house chemical munitions, but changes are underway by the U.S. Army Chemical Materials Agency to destroy these munitions and make the site environmentally safe for reuse -- while also protecting the surrounding local environment. The stippled landscape pattern visible from low Earth orbit is due to hundreds of concrete and earth-covered storage "igloos" that form ordered rows across the site (top). It is within these igloos that chemical munitions and other materials are stored. Larger, white roofed maintenance buildings once used for munitions storage were built with separate compartments to minimize potential damage from explosions. Other features visible in this detailed image include linear roadway (light tan) and rail (dark brown) lines, black irregular surface impoundments of water, and various rectangular office and industrial buildings at lower left.

Department of Defense Base Structure Report (A Summary of DoD’s Real Property Inventory) Fiscal Year 2006 Baseline

DTIC Science & Technology

2006-01-01

438 1,964,339 7,6767,117 762.7 28 0 0Navy Active NMCRC Miami Miami 2 62,752 2017 10.7 1,215 2 0Navy Reserve NS Mayport FL Mayport 646 3,822,934 16...3,746 724403 17.8AF Active Lone Star AAP Texarkana 876 3,264,503 15,69915,699 841.3 1 18 0Army Active C Lonestar Pecos Electronic Scoring Site Pecos 2...1,183.5 3,201 5,355 0AF Active R Red River Army Depot Texarkana 1,125 7,555,228 18 173,594 18,31618,316 1,558.5 144 1,894 1,838Army Active R Saginaw

Simulations of cataclysmic outburst floods from Pleistocene Glacial Lake Missoula

USGS Publications Warehouse

Denlinger, Roger P.; O'Connell, D. R. H.

2009-01-01

Using a flow domain that we constructed from 30 m digital-elevation model data of western United States and Canada and a two-dimensional numerical model for shallow-water flow over rugged terrain, we simulated outburst floods from Pleistocene Glacial Lake Missoula. We modeled a large, but not the largest, flood, using initial lake elevation at 1250 m instead of 1285 m. Rupture of the ice dam, centered on modern Lake Pend Oreille, catastrophically floods eastern Washington and rapidly fills the broad Pasco, Yakima, and Umatilla Basins. Maximum flood stage is reached in Pasco and Yakima Basins 38 h after the dam break, whereas maximum flood stage in Umatilla Basin occurs 17 h later. Drainage of these basins through narrow Columbia gorge takes an additional 445 h. For this modeled flood, peak discharges in eastern Washington range from 10 to 20 × 106 m3/s. However, constrictions in Columbia gorge limit peak discharges to 6 m3/s and greatly extend the duration of flooding. We compare these model results with field observations of scabland distribution and high-water indicators. Our model predictions of the locations of maximum scour (product of bed shear stress and average flow velocity) match the distribution of existing scablands. We compare model peak stages to high-water indicators from the Rathdrum-Spokane valley, Walulla Gap, and along Columbia gorge. Though peak stages from this less-than-maximal flood model attain or exceed peak-stage indicators along Rathdrum-Spokane valley and along Columbia gorge, simulated peak stages near Walulla Gap are 10–40 m below observed peak-stage indicators. Despite this discrepancy, our match to field observations in most of the region indicates that additional sources of water other than Glacial Lake Missoula are not required to explain the Missoula floods.

Proceedings of the Technology Transfer Seminar/Workshop on the Application of Pollution Abatement Technology to Local Governments

DTIC Science & Technology

1975-05-01

civil agencies through interage..:y agreements. One of the Navy field activities, the Naval Ammunition Depot at Crane , Indiana, has developed rather...chemical mixing compartment and chem- ical dosing tank assures adequate contact time. Solids and organics are hydrolyzed by the caustic , while the...The high caustic level of the treated waste water resulted in corrosion to various points in the system. Pumps required extensive weekly maintenance

An Archeological Overview and Management Plan for the Pueblo Depot Activity, Pueblo County, Colorado.

DTIC Science & Technology

1984-10-01

may have architectural details or history which could be important to historic preservationists. The rich history of Pueblo and the fact that many...humus- rich alluvium found along the Arkansas River and its tributaries. Osteological remains taken from Piney Creek alluvium include bison, antelope...n.d.:225). By 1900 the area had become a rich agricultural region. The expansion of large-scale irrigation projects and the rise of the dry farming

Review and Evaluation of Army Aviation Depot NDI (Nondestructive Inspection) and Reliability Centered Maintenance

DTIC Science & Technology

1988-08-31

behavior/operational goals so tnat corrective action may be taken. Data produced by the IS activities form the basis for design/--1pport trade-offs while...rt7L:EC T Ef Approved for public release; distribution unlimited c R SOUTHWEST RESEARCH INSTITUTE SAN ANTONIO HOUSTON I SECURITY CLASSIFICATION OF THIS...DISTRIBUTION/AVAILABLITY OF REPORT Approved for public release; 2b. DECLASSIFICATION I DOWNGRADING SCHEDULE distribution unlimited 4 PERFORMING ORGANIZATION

Cloning of peroxisome proliferators activated receptors in the cobia (Rachycentron canadum) and their expression at different life-cycle stages under cage aquaculture.

PubMed

Tsai, Mei-Ling; Chen, Houng-Yung; Tseng, Mei-Cheuh; Chang, Rey-Chang

2008-12-01

We present the cDNA sequences and tissue mRNA expression of peroxisome proliferator-activated receptor (PPAR) alpha, beta and gamma isotypes in the cobia (Rachycentron canadum), a warm water pelagic fish that is becoming a fish of choice for offshore cage farming. RT-PCR and real-time PCR showed that PPARalpha mRNA predominated in red muscle, heart and liver whereas PPARbeta was expressed mainly in liver and pyloric caeca. In contrast, PPARgamma transcripts were detected in all of the tissues examined, with the highest level occurring in visceral fat depot. Our 52-wk time-series investigation showed that while the mRNA expression of PPARgamma in the cobia was positively (P < 0.05) related to its body lipid deposition, a negative (P < 0.05) relationship was found between PPARalpha expression in the liver and body lipid deposition. There was a significant increase in body lipid deposition and hepatic PPARgamma expression as the fish grew. The hepatic PPARgamma expression could be a sufficient parameter describing the bodily expression of PPARgamma because of its positive correlation with PPARgamma expressions in all other tissues. These results showed that PPARgamma and alpha played a pivotal role in the control of lipid metabolic and storage functions in the liver, muscle and visceral fat depot of the cobia.

Fetal Origins of Life Stage Disease: A Zebrafish Model for the ...

EPA Pesticide Factsheets

In the U.S., childhood obesity has more than doubled in children and quadrupled in adolescents in the past 30 years, affects 35% of adults, and costs the U.S. healthcare industry >$200 billion annually. The chemical environment in the womb may cause susceptibility to different life-stage and life-long metabolic diseases including obesity. The challenge is to understand if exposures during developmentally sensitive windows impact life-stage disease, such as obesity, by increasing adipose tissue mass. In vitro models lack the integrated systems approach needed to assess adipose development, while mammalian models are impractical in a screen of thousands of chemicals. Therefore, an obesogen screening method was developed to interrogate bioactivity using a full systems approach, in a vertebrate zebrafish model with complete metabolic activity, at a time when the full signaling repertoire is expressed and active, to optimally examine how chemical dose and duration impact life-stage adipose mass. A time-line for adipose depot formation was mapped in zebrafish 6−14 days post fertilization (dpf) using the lipophilic dye, Nile Red, in combination with fluorescent microscopy. Those time points were then used to investigate the impact of embryonic tributyltin chloride (TBT, a known obesogen) exposure (10nM daily renewal, 0−5dpf) on adipose mass. Fluorescent microscopy revealed adipose depots that were larger and appeared 2 days earlier in TBT treated compared to contro

Direct and Indirect Effects of Leptin on Adipocyte Metabolism

PubMed Central

Harris, Ruth B.S.

2013-01-01

Leptin is hypothesized to function as a negative feedback signal in the regulation of energy balance. It is produced primarily by adipose tissue and circulating concentrations correlate with the size of body fat stores. Administration of exogenous leptin to normal weight, leptin responsive animals inhibits food intake and reduces the size of body fat stores whereas mice that are deficient in either leptin or functional leptin receptors are hyperphagic and obese, consistent with a role for leptin in the control of body weight. This review discusses the effect of leptin on adipocyte metabolism. Because adipocytes express leptin receptors there is the potential for leptin to influence adipocyte metabolism directly. Adipocytes also are insulin responsive and receive sympathetic innervation, therefore leptin can also modify adipocyte metabolism indirectly. Studies published to date suggest that direct activation of adipocyte leptin receptors has little effect on cell metabolism in vivo, but that leptin modifies adipocyte sensitivity to insulin to inhibit lipid accumulation. In vivo administration of leptin leads to a suppression of lipogenesis, an increase in triglyceride hydrolysis and an increase in fatty acid and glucose oxidation. Activation of central leptin receptors also contributes to the development of a catabolic state in adipocytes, but this may vary between different fat depots. Leptin reduces the size of white fat depots by inhibiting cell proliferation both through induction of inhibitory circulating factors and by contributing to sympathetic tone which suppresses adipocyte proliferation. PMID:23685313

Transport properties of active Brownian particles in a modified energy-depot model driven by correlated noises

NASA Astrophysics Data System (ADS)

Guan, Lin; Fang, Yuwen; Li, Kongzhai; Zeng, Chunhua; Yang, Fengzao

2018-09-01

In this paper, we investigate the role of correlated multiplicative (κ1) and additive (κ2) noises in a modified energy conversion depot model, at which it is added a linear term in the conversion of internal energy of active Brownian particles (ABPs). The linear term (a1 ≠ 0 . 0) in energy conversion model breaks the symmetry of the potential to generate motion of the ABPs with a net transport velocity. Adopt a nonlinear Langevin approach, the transport properties of the ABPs have been discussed, and our results show that: (i) the transport velocity <υ1 > of the ABPs are always positive whether the correlation intensity λ = 0 . 0 or not; (ii) for a small value of the multiplicative noise intensity κ1, the variation of <υ1 > with λ shows a minimum, there exists an optimal value of the correlation intensity λ at which the <υ1 > of the ABPs is minimized. But for a large value of κ1, the <υ1 > monotonically decreases; (iii) the transport velocity <υ1 > increases with the increase of the κ1 or κ2, i.e., the multiplicative or additive noise can facilitate the transport of the ABPs; and (iv) the effective diffusion increases with the increase of a1, namely, the linear term in modified energy conversion model of the ABPs can enhance the diffusion of the ABPs.

Brown Adipose Tissue Quantification in Human Neonates Using Water-Fat Separated MRI

PubMed Central

Rasmussen, Jerod M.; Entringer, Sonja; Nguyen, Annie; van Erp, Theo G. M.; Guijarro, Ana; Oveisi, Fariba; Swanson, James M.; Piomelli, Daniele; Wadhwa, Pathik D.

2013-01-01

There is a major resurgence of interest in brown adipose tissue (BAT) biology, particularly regarding its determinants and consequences in newborns and infants. Reliable methods for non-invasive BAT measurement in human infants have yet to be demonstrated. The current study first validates methods for quantitative BAT imaging of rodents post mortem followed by BAT excision and re-imaging of excised tissues. Identical methods are then employed in a cohort of in vivo infants to establish the reliability of these measures and provide normative statistics for BAT depot volume and fat fraction. Using multi-echo water-fat MRI, fat- and water-based images of rodents and neonates were acquired and ratios of fat to the combined signal from fat and water (fat signal fraction) were calculated. Neonatal scans (n = 22) were acquired during natural sleep to quantify BAT and WAT deposits for depot volume and fat fraction. Acquisition repeatability was assessed based on multiple scans from the same neonate. Intra- and inter-rater measures of reliability in regional BAT depot volume and fat fraction quantification were determined based on multiple segmentations by two raters. Rodent BAT was characterized as having significantly higher water content than WAT in both in situ as well as ex vivo imaging assessments. Human neonate deposits indicative of bilateral BAT in spinal, supraclavicular and axillary regions were observed. Pairwise, WAT fat fraction was significantly greater than BAT fat fraction throughout the sample (ΔWAT-BAT = 38%, p<10−4). Repeated scans demonstrated a high voxelwise correlation for fat fraction (Rall = 0.99). BAT depot volume and fat fraction measurements showed high intra-rater (ICCBAT,VOL = 0.93, ICCBAT,FF = 0.93) and inter-rater reliability (ICCBAT,VOL = 0.86, ICCBAT,FF = 0.93). This study demonstrates the reliability of using multi-echo water-fat MRI in human neonates for quantification throughout the torso of BAT depot volume and fat fraction measurements. PMID:24205024

Association between individual fat depots and cardio-metabolic traits in normal- and overweight children, adolescents and adults.

PubMed

Hübers, M; Geisler, C; Plachta-Danielzik, S; Müller, M J

2017-05-08

To determine age-related associations between fat mass (FM), regional fat depots and cardiometabolic traits in normal- and overweight children, adolescents and adults. Detailed body composition (regional subcutaneous and visceral adipose tissue; SAT, VAT) by whole-body magnetic resonance imaging (MRI), FM and fat-free mass by air-displacement plethysmography, systolic and diastolic blood pressure (SBP, DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL), plasma glucose and plasma insulin were measured in 433 subjects (BMI: 23.6 (21.0-27.7); 151 children and adolescents, aged 6-18 years, 150 young adults, aged 18-30 years and 132 adults, aged 30-60 years). Data were derived from pooled data of the 'Reference Center for Body Composition' in Kiel, Germany. Insulin resistance was determined by the homeostatic model assessment of insulin resistance (HOMA-IR). Partial correlations and multivariate linear regression analyses were used to evaluate the associations between body composition and cardiometabolic traits. A descriptive approach was used to demonstrate age-dependent differences in associations between body fat depots and insulin resistance, independent of BMI. FM, SAT, and VAT increased from childhood to adulthood with low VAT in children and adolescents. When compared to children, TG was higher in adults. HDL and DBP did not differ between age groups. Insulin resistance was highest in male adolescents and female young adults. Associations between body fat depots and cardiometabolic traits were seen after puberty with no associations in pre- and intrapubertal children. When compared to FM, SAT and VAT had the strongest association with insulin resistance in adults. This association was independent of BMI. Associations between individual body fat depots and most cardiometabolic traits became evident after puberty only. The strongest associations were observed between insulin resistance and abdominal fat in adults. The impact of VAT was independent of BMI.

Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate.

PubMed

Klein, Karen O; Dragnic, Sanja; Soliman, Ahmed M; Bacher, Peter

2018-05-11

Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relationships between growth, rate of bone maturation (bone age/chronological age [ΔBA/ΔCA]), luteinizing hormone (LH), predicted adult stature (PAS), as well as variables influencing these outcomes, were studied in children treated with depot leuprolide (LA Depot) Methods: Subjects (64 girls, seven boys) with CPP received LA Depot every 3 months for up to 42 months. Multivariate regression analyses were conducted to examine the predictors affecting ΔBA/ΔCA, PAS and growth rate. Ninety percent of subjects (18 of 20) were suppressed (LH levels <4 IU/L) at 42 months. Over 42 months, the mean growth rate declined 2 cm/year, the mean BA/CA ratio decreased 0.21 and PAS increased 8.90 cm for girls (n=64). PAS improved to mid-parental height (MPH) in 46.2% of children by 30 months of treatment. Regression analysis showed that only the Body Mass Index Standardized Score (BMI SDS) was significantly associated (β+0.378 and +0.367, p≤0.05) with growth rate. For PAS, significant correlations were with MPH (β+0.808 and +0.791, p<0.001) and ΔBA/ΔCA (β+0.808 and +0.791, p<0.001). For ΔBA/ΔCA, a significant association was found only with BA at onset of treatment (β-0.098 and -0.103, p≤0.05). Peak-stimulated or basal LH showed no significant influence on growth rate, ΔBA/ΔCA or PAS. Growth rate and bone maturation rate normalized on treatment with LA Depot. LH levels were not significantly correlated with growth rate, ΔBA/ΔCA or PAS, suggesting that suppression was adequate and variations in gonadotropin levels were below the threshold affecting outcomes.

Impairment of nutritional regulation of adipose triglyceride lipase expression with age.

PubMed

Caimari, A; Oliver, P; Palou, A

2008-08-01

Fasting-induced lipolysis becomes less effective with age. We have studied whether nutritional regulation of adipose triglyceride lipase (ATGL)--with an important role in lipolysis in low energy states--is affected by age. Wistar rats of different ages (from 1 to 13 months) were distributed in control and fasted groups (14 h-food deprivation). ATGL mRNA expression was measured in different adipose depots at different ages and in only one depot at 13 months by reverse transcription (RT)-PCR. ATGL protein levels were determined at 3 and 7 months (not at 13 months) by western blot. Nonesterified fatty acid (NEFA), insulin and leptin levels were assessed in serum by enzymatic assays. ATGL expression was dependent on regional fat distribution, with higher levels in brown than in white adipose tissue depots; and was affected by age: ATGL mRNA was increased with age in the brown adipose tissue and was decreased in two of the studied white depots, the inguinal and retroperitoneal, not being affected in the epididymal and mesenteric. Age also affected ATGL nutritional regulation: fasting increased ATGL gene expression and protein levels in the different white adipose depots of the youngest rats (up to the age of 5 months), whereas there was no change in the oldest rats studied (7 and 13-months old). This was in agreement with the pattern of NEFA levels, which did not increase in serum of fasted rats in the oldest animals, whereas other homeostatic parameters, such as insulin and leptin, responded to fasting independently of age. ATGL expressed by brown adipose tissue was not affected by feeding conditions at any age. Nutritional regulation of ATGL expression in white adipose tissue is impaired with age, which could contribute to the increased difficulty for mobilizing lipids when animals are exposed to nutritional stress such as fasting.

Is testosterone replacement therapy in males with hypogonadism cost-effective? An analysis in Sweden.

PubMed

Arver, Stefan; Luong, Ba; Fraschke, Anina; Ghatnekar, Ola; Stanisic, Sanja; Gultyev, Dmitry; Müller, Elvira

2014-01-01

Testosterone replacement therapy (TRT) has been recommended for the treatment of primary and secondary hypogonadism. However, long-term implications of TRT have not been investigated extensively. The aim of this analysis was to evaluate health outcomes and costs associated with life-long TRT in patients suffering from Klinefelter syndrome and late-onset hypogonadism (LOH). A Markov model was developed to assess cost-effectiveness of testosterone undecanoate (TU) depot injection treatment compared with no treatment. Health outcomes and associated costs were modeled in monthly cycles per patient individually along a lifetime horizon. Modeled health outcomes included development of type 2 diabetes, depression, cardiovascular and cerebrovascular complications, and fractures. Analysis was performed for the Swedish health-care setting from health-care payer's and societal perspective. One-way sensitivity analyses evaluated the robustness of results. The main outcome measures were quality-adjusted life-years (QALYs) and total cost in TU depot injection treatment and no treatment cohorts. In addition, outcomes were also expressed as incremental cost per QALY gained for TU depot injection therapy compared with no treatment (incremental cost-effectiveness ratio [ICER]). TU depot injection compared to no-treatment yielded a gain of 1.67 QALYs at an incremental cost of 28,176 EUR (37,192 USD) in the Klinefelter population. The ICER was 16,884 EUR (22,287 USD) per QALY gained. Outcomes in LOH population estimated benefits of TRT at 19,719 EUR (26,029 USD) per QALY gained. Results showed to be considerably robust when tested in sensitivity analyses. Variation of relative risk to develop type 2 diabetes had the highest impact on long-term outcomes in both patient groups. This analysis suggests that lifelong TU depot injection therapy of patients with hypogonadism is a cost-effective treatment in Sweden. Hence, it can support clinicians in decision making when considering appropriate treatment strategies for patients with testosterone deficiency. © 2013 International Society for Sexual Medicine.

Army Depot Maintenance: More Effective Use of Organic and Contractor Resources

DTIC Science & Technology

1990-06-04

terkerrny (PA) RRAD Red River (TX) IBAD Lexingtor).Bluegrass (KY) 3MPUAD Pueblo (CO) 2000 ANAD CCAD TEAD TOAD SAAO LEAD FMD LBAD PUAfl j] Aut)’onzed Onboard...until it is received by the contractor. That problem could be eliminated by redesigning the process. Specifically, the FTA document that notifies the...should revise CCSS to allow the FTM document to generate an image to LCA, the FTA to create a due-in to the contractor, and CCSS to determine the depot

Documentation and Analysis of the ’Miscellaneous’ Account Category within the DoD Instruction 7220.29-H Depot Level Maintenance Cost Accounting System.

DTIC Science & Technology

1984-12-01

34MISCELLANEOUS" ACCOUNT CATEGORY WITHIN THE DOD INSTRUCTION 7220.29-H DEPOT LEVEL MAINTENANCE COST ACCOUNTING SYSTEM by a. Steven Eugene Lehr CDecember 1984...PERFORMING ONG. REPORT NUMBER Maintenance Cost Accounting System 7. AUTHOR(&) S. CONTRACT OR GRANT NUMBER(@) Steven Eugene Lehr 9. PERFORMING ORGANIZATION...Availability Codes IS. KEY WORDS (Continue on reverse *ids It necessary and Identify by block number) Dvi Special Uniform Cost Accounting System DoD

Implementation of Improved Management Control of Aviation Depot Level Repairable Funds

DTIC Science & Technology

1986-12-01

for comparing and testing. Pf ter Drucker states that ". . . control is an ambiguous word. It means the abiliti to direct oneself and one’s work. It...Frequency 50 LIST OF REFERENCES 1. Drucker , Peter F., The Practice of Management , Harper and Brothers Publishers, 1954. 2. Terry, George R., Principles of...NAVAL POSTGRADUATE SCHOOLMonterey, California 0- 6~~VI E1B9 87THESIS I IMPLEMENTATION OF IMPROVED MANAGEMENT CONTROL OF AVIATION DEPOT LEVEL

Analysis Of The Effects Of Marine Corps M1A1 Abram’s Tank Age On Operational Availability

DTIC Science & Technology

2014-06-01

effects of age, as measured by the time since the last depot- level rebuild, on equipment operational availability for the M1A1 MBT in the Marine Corps...prior M1A1 reliability studies. We reviewed depot- and unit- level maintenance records within the USMC’s System Operational Effectiveness database to... Level Maintenance 15. NUMBER OF PAGES 67 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY CLASSIFICATION OF

Breast Cancer Lymphatic Dissemination-Influence of Estrogen and Progesterone

DTIC Science & Technology

2007-03-01

Monthly depot injections (.1 mg/body kg) of leuprorelin acetate (LA) and of triptorelin (TR) were continuously administered for 40.4 .7 months to 34...Leuprorelin acetate; Precocious puberty; Thyroid; Triptorelin a a n ( ( a l T r ( a d s h Since the 1980s, long-acting gonadotropin-releasing hor- one...53.4%) received triptorelin depot IM (De- apeptyl, Ipsen Pharma Biotech S.A., Toulon Cedex, rance) at a mean dose of .1 mg/body kg every 28 days (TR

The Uniform Cost Accounting System and Stabilized Rates at Anniston Army Depot, Anniston, Alabama.

DTIC Science & Technology

1985-12-01

Requirements DoD Department of Defense EIMDR End Item Materiel Data Record - FY Fiscal Year 9 *4N GAAP Generally Accepted Accounting Principles GAE...objec- tive of enhancing customer convenience by holding depot bill- ing rates constant throughout the fiscal year. However, they have done so at the...stabilized rate. The Department of the Army’s decision to hold the unit cost of the D160Al to $91,144 in June of 1976 further compounded the situation

Proceedings of the 1980 Tri-Service Conference on Corrosion, 5-7 November 1980, US Air Force Academy, Colorado. Volume 2

DTIC Science & Technology

1980-11-01

the potential fiield vacialions at a plane parallel to the sample surface. The signals can also be recorded on a storage oscilloscope and photographed... storage , and overhaul is performed at the J jappropriate depot(s). If a program requires intensive management, a project manager is dcsignated and...the program include the conduct of a Triennial inspection of DARCOM facilities, thc establishment of a Materiel Deterioration Information Certer, the

Ecological risk assessment for detonation emissions at an Army Depot

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weisberg, M.; Fischer, T.

1999-07-01

Treatment of munitions at an Army Depot located in Nevada required a RCRA Part B Subpart X permit. Part of the permitting requirements were to assess ecological impacts from emissions associated with the detonation (treatment) of the munitions. A multi-media multi-pathway ecological risk assessment was performed to assess these impacts. Food-chain exposure, as well as intake of impacted soil, was considered. Of the eight selected receptor wildlife species, estimated hazard quotients were all below thresholds of concern.