Sequential Service Restoration for Unbalanced Distribution Systems and Microgrids

DOE PAGES

Chen, Bo; Chen, Chen; Wang, Jianhui; ...

2017-07-07

The resilience and reliability of modern power systems are threatened by increasingly severe weather events and cyber-physical security events. An effective restoration methodology is desired to optimally integrate emerging smart grid technologies and pave the way for developing self-healing smart grids. In this paper, a sequential service restoration (SSR) framework is proposed to generate restoration solutions for distribution systems and microgrids in the event of large-scale power outages. The restoration solution contains a sequence of control actions that properly coordinate switches, distributed generators, and switchable loads to form multiple isolated microgrids. The SSR can be applied for three-phase unbalanced distributionmore » systems and microgrids and can adapt to various operation conditions. Mathematical models are introduced for three-phase unbalanced power flow, voltage regulators, transformers, and loads. Furthermore, the SSR problem is formulated as a mixed-integer linear programming model, and its effectiveness is evaluated via the modified IEEE 123 node test feeder.« less

Sequential Service Restoration for Unbalanced Distribution Systems and Microgrids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Bo; Chen, Chen; Wang, Jianhui

The resilience and reliability of modern power systems are threatened by increasingly severe weather events and cyber-physical security events. An effective restoration methodology is desired to optimally integrate emerging smart grid technologies and pave the way for developing self-healing smart grids. In this paper, a sequential service restoration (SSR) framework is proposed to generate restoration solutions for distribution systems and microgrids in the event of large-scale power outages. The restoration solution contains a sequence of control actions that properly coordinate switches, distributed generators, and switchable loads to form multiple isolated microgrids. The SSR can be applied for three-phase unbalanced distributionmore » systems and microgrids and can adapt to various operation conditions. Mathematical models are introduced for three-phase unbalanced power flow, voltage regulators, transformers, and loads. Furthermore, the SSR problem is formulated as a mixed-integer linear programming model, and its effectiveness is evaluated via the modified IEEE 123 node test feeder.« less

Characteristics of TCM constitutions of adult Chinese women in Hong Kong and identification of related influencing factors: a cross-sectional survey.

PubMed

Sun, Youzhi; Liu, Pei; Zhao, Yi; Jia, Lei; He, Yanhua; Xue, Steve An; Zheng, Xiao; Wang, Zhiyu; Wang, Neng; Chen, Jianping

2014-05-21

Traditional Chinese Medicine Constitution (TCMC) refers to an integrated, metastable and natural specialty of individual in morphosis, physiological functions and psychological conditions. It is formed on the basis of innate and acquired endowments in the human life process, which can be divided into normal constitution and unbalanced ones. The aim of this study was to investigate the distribution of TCMCs of Chinese women in Hong Kong and its acquired influencing factors. Local Chinese women between 30 to 65 years old, were recruited from 18 districts of Hong Kong (n=944), and were assessed using the Traditional Chinese Medicine Physical Constitution Scale for their TCMC types. Social-demographic, reproductive, lifestyle, systemic health and emotional status information were collected through structured questionnaire. The associations between different independent factors and each TCMC type, as well as the complex unbalanced TCMC types were tested individually. Significant factors related to unbalanced TCMC types were identified in final models using multiple factor analysis. A total of 764 (80.9%) participants were diagnosed with unbalanced TCMCs. The most common TCMC type was Qi-deficiency constitution (53.9%), followed by Phlegm-wetness (38.9%), Yang-deficiency (38.2%), Yin-deficiency (35.5), Blood-stasis (35.4) and Qi-depressed (31%) constitution. Six hundred and eleven participants (64.7%) had at least two types of combined and unbalanced constitutions. Stepwise logistic analysis indicated that poor systemic health condition (OR, 1.76-2.89), negative emotions (OR=1.39), overweight (OR=1.58), high educational level (OR=1.18) and mental work (OR=1.44) were significantly positively correlated with certain unbalanced TCMCs. Meanwhile, aging (OR, 0.59-0.73), exercise habit (OR, 0.61-0.79) and reproductive history (OR=0.72) showed inverse associations with unbalanced constitutions. In addition, systemic health condition and emotional status, exercise habit and age were significantly associated with the combined unbalanced TCMC types. The majority of middle-aged Chinese women in Hong Kong had unbalanced and complex TCMCs. Qi-deficiency, Phlegm-wetness and Yang-deficiency constitutions are the most common constitutions. Poor systemic health condition, less-than-satisfactory emotional life, overweight and mental work are associated with and may be contributors for the formation of unbalanced TCMCs, while regular physical exercise was found to be a potential protective factor for unbalanced TCMCs.

Effect of unbalanced magnetic pull and hydraulic seal force on the vibration of large rotor-bearing systems

NASA Astrophysics Data System (ADS)

Song, Z.; Guo, P.; Liu, Y.

2014-03-01

The influence of unbalanced magnetic pull (UMP) and hydraulic seal force on the vibration of large rotor-bearing systems is studied. The UMP caused by rotor eccentricity imposes important effects on rotating machinery, especially for large generators such as water turbine generator sets, because these machines operate above their first critical speed in some instances and are supported by oil film bearings. A magnetic stiffness matrix for studying the effects of the UMP is proposed. The magnetic stiffness matrix can be generated by decomposing the expression of air gap magnetic field energy. Two vibration models are constructed using the Lagrange equation. The difference between the two models lies in the boundary support condition: one has rigid support and the other has elastic bearing support. The influence of the magnetic stiffness and elastic support on the critical speed of the rotor is studied using Lyapunov nonlinear vibration stability theory. The vibration amplitude of the rotor is calculated, taking the magnetic stiffness and horizontal centrifugal force into account. The unbalanced hydraulic seal force is produced because of the asymmetry of seal clearance. This imbalance is one of the factors that causes self-excited vibration in rotating machinery, and is as important as the UMP for large water turbine generator sets. The rotor-bearing system is supported by an oil film journal bearing, whose characteristic also impose considerable influence on vibration. On the basis of the above-mentioned conditions, a three-dimensional finite element model of the rotating system that includes the oil film journal bearing is constructed. The effect of the UMP and unbalanced hydraulic seal force is considered in the construction, and studied in relation to the magnetic parameters, seal parameters, journal bearing stiffness, and outer diameter of the rotating machine critical speed. Conclusions may benefit the dynamic design and optimized operation of large rotating machinery.

Unbalanced field RF electron gun

DOEpatents

Hofler, Alicia

2013-11-12

A design for an RF electron gun having a gun cavity utilizing an unbalanced electric field arrangement. Essentially, the electric field in the first (partial) cell has higher field strength than the electric field in the second (full) cell of the electron gun. The accompanying method discloses the use of the unbalanced field arrangement in the operation of an RF electron gun in order to accelerate an electron beam.

A Parallel Biological Optimization Algorithm to Solve the Unbalanced Assignment Problem Based on DNA Molecular Computing.

PubMed

Wang, Zhaocai; Pu, Jun; Cao, Liling; Tan, Jian

2015-10-23

The unbalanced assignment problem (UAP) is to optimally resolve the problem of assigning n jobs to m individuals (m < n), such that minimum cost or maximum profit obtained. It is a vitally important Non-deterministic Polynomial (NP) complete problem in operation management and applied mathematics, having numerous real life applications. In this paper, we present a new parallel DNA algorithm for solving the unbalanced assignment problem using DNA molecular operations. We reasonably design flexible-length DNA strands representing different jobs and individuals, take appropriate steps, and get the solutions of the UAP in the proper length range and O(mn) time. We extend the application of DNA molecular operations and simultaneity to simplify the complexity of the computation.

Characteristics of TCM constitutions of adult Chinese women in Hong Kong and identification of related influencing factors: a cross-sectional survey

PubMed Central

2014-01-01

Background Traditional Chinese Medicine Constitution (TCMC) refers to an integrated, metastable and natural specialty of individual in morphosis, physiological functions and psychological conditions. It is formed on the basis of innate and acquired endowments in the human life process, which can be divided into normal constitution and unbalanced ones. The aim of this study was to investigate the distribution of TCMCs of Chinese women in Hong Kong and its acquired influencing factors. Methods Local Chinese women between 30 to 65years old, were recruited from 18 districts of Hong Kong (n = 944), and were assessed using the Traditional Chinese Medicine Physical Constitution Scale for their TCMC types. Social-demographic, reproductive, lifestyle, systemic health and emotional status information were collected through structured questionnaire. The associations between different independent factors and each TCMC type, as well as the complex unbalanced TCMC types were tested individually. Significant factors related to unbalanced TCMC types were identified in final models using multiple factor analysis. Results A total of 764 (80.9%) participants were diagnosed with unbalanced TCMCs. The most common TCMC type was Qi-deficiency constitution (53.9%), followed by Phlegm-wetness (38.9%), Yang-deficiency (38.2%), Yin-deficiency (35.5), Blood-stasis (35.4) and Qi-depressed (31%) constitution. Six hundred and eleven participants (64.7%) had at least two types of combined and unbalanced constitutions. Stepwise logistic analysis indicated that poor systemic health condition (OR, 1.76-2.89), negative emotions (OR = 1.39), overweight (OR = 1.58), high educational level (OR = 1.18) and mental work (OR = 1.44) were significantly positively correlated with certain unbalanced TCMCs. Meanwhile, aging (OR, 0.59-0.73), exercise habit (OR, 0.61-0.79) and reproductive history (OR = 0.72) showed inverse associations with unbalanced constitutions. In addition, systemic health condition and emotional status, exercise habit and age were significantly associated with the combined unbalanced TCMC types. Conclusion The majority of middle-aged Chinese women in Hong Kong had unbalanced and complex TCMCs. Qi-deficiency, Phlegm-wetness and Yang-deficiency constitutions are the most common constitutions. Poor systemic health condition, less-than-satisfactory emotional life, overweight and mental work are associated with and may be contributors for the formation of unbalanced TCMCs, while regular physical exercise was found to be a potential protective factor for unbalanced TCMCs. PMID:24886055

A Parallel Biological Optimization Algorithm to Solve the Unbalanced Assignment Problem Based on DNA Molecular Computing

PubMed Central

Wang, Zhaocai; Pu, Jun; Cao, Liling; Tan, Jian

2015-01-01

The unbalanced assignment problem (UAP) is to optimally resolve the problem of assigning n jobs to m individuals (m < n), such that minimum cost or maximum profit obtained. It is a vitally important Non-deterministic Polynomial (NP) complete problem in operation management and applied mathematics, having numerous real life applications. In this paper, we present a new parallel DNA algorithm for solving the unbalanced assignment problem using DNA molecular operations. We reasonably design flexible-length DNA strands representing different jobs and individuals, take appropriate steps, and get the solutions of the UAP in the proper length range and O(mn) time. We extend the application of DNA molecular operations and simultaneity to simplify the complexity of the computation. PMID:26512650

Passive cyclic pitch control for horizontal axis wind turbines

NASA Technical Reports Server (NTRS)

Bottrell, G. W.

1981-01-01

A flexible rotor concept, called the balanced pitch rotor, is described. The system provides passive adjustment of cyclic pitch in response to unbalanced pitching moments across the rotor disk. Various applications are described and performance predictions are made for wind shear and cross wind operating conditions. Comparisons with the teetered hub are made and significant cost savings are predicted.

Phenotypic Signatures Arising from Unbalanced Bacterial Growth

PubMed Central

Tan, Cheemeng; Smith, Robert Phillip; Tsai, Ming-Chi; Schwartz, Russell; You, Lingchong

2014-01-01

Fluctuations in the growth rate of a bacterial culture during unbalanced growth are generally considered undesirable in quantitative studies of bacterial physiology. Under well-controlled experimental conditions, however, these fluctuations are not random but instead reflect the interplay between intra-cellular networks underlying bacterial growth and the growth environment. Therefore, these fluctuations could be considered quantitative phenotypes of the bacteria under a specific growth condition. Here, we present a method to identify “phenotypic signatures” by time-frequency analysis of unbalanced growth curves measured with high temporal resolution. The signatures are then applied to differentiate amongst different bacterial strains or the same strain under different growth conditions, and to identify the essential architecture of the gene network underlying the observed growth dynamics. Our method has implications for both basic understanding of bacterial physiology and for the classification of bacterial strains. PMID:25101949

Phenotypic signatures arising from unbalanced bacterial growth.

PubMed

Tan, Cheemeng; Smith, Robert Phillip; Tsai, Ming-Chi; Schwartz, Russell; You, Lingchong

2014-08-01

Fluctuations in the growth rate of a bacterial culture during unbalanced growth are generally considered undesirable in quantitative studies of bacterial physiology. Under well-controlled experimental conditions, however, these fluctuations are not random but instead reflect the interplay between intra-cellular networks underlying bacterial growth and the growth environment. Therefore, these fluctuations could be considered quantitative phenotypes of the bacteria under a specific growth condition. Here, we present a method to identify "phenotypic signatures" by time-frequency analysis of unbalanced growth curves measured with high temporal resolution. The signatures are then applied to differentiate amongst different bacterial strains or the same strain under different growth conditions, and to identify the essential architecture of the gene network underlying the observed growth dynamics. Our method has implications for both basic understanding of bacterial physiology and for the classification of bacterial strains.

Re-conceptualizing stress: Shifting views on the consequences of stress and its effects on stress reactivity.

PubMed

Liu, Jenny J W; Vickers, Kristin; Reed, Maureen; Hadad, Marilyn

2017-01-01

The consequences of stress are typically regarded from a deficit-oriented approach, conceptualizing stress to be entirely negative in its outcomes. This approach is unbalanced, and may further hinder individuals from engaging in adaptive coping. In the current study, we explored whether negative views and beliefs regarding stress interacted with a stress framing manipulation (positive, neutral and negative) on measures of stress reactivity for both psychosocial and physiological stressors. Ninety participants were randomized into one of three framing conditions that conceptualized the experience of stress in balanced, unbalanced-negative or unbalanced-positive ways. After watching a video on stress, participants underwent a psychosocial (Trier Social Stress Test), or a physiological (CO2 challenge) method of stress-induction. Subjective and objective markers of stress were assessed. Most of the sampled population regarded stress as negative prior to framing. Further, subjective and objective reactivity were greater to the TSST compared to the CO2 challenge. Additionally, significant cubic trends were observed in the interactions of stress framing and stress-induction methodologies on heart rate and blood pressure. Balanced framing conditions in the TSST group had a significantly larger decrease in heart rate and diastolic blood pressure following stress compared to the positive and negative framing conditions. Findings confirmed a deficit-orientation of stress within the sampled population. In addition, results highlighted the relative efficacy of the TSST compared to CO2 as a method of stress provocation. Finally, individuals in framing conditions that posited stress outcomes in unbalanced manners responded to stressors less efficiently. This suggests that unbalanced framing of stress may have set forth unrealistic expectations regarding stress that later hindered individuals from adaptive responses to stress. Potential benefits of alternative conceptualizations of stress on stress reactivity are discussed, and suggestions for future research are made.

Thin-Wire Modeling Techniques Applied to Antenna Analysis.

DTIC Science & Technology

1974-10-11

Ol- MULT11 CRN LOOP ANTENNA ... 30 2.4.1 Balanced vs unbalanced operation ... 3 1 2.4.2 Horizontal vs vertical configuration ... 33 3.0...of the Ml A-l Mimloop ... 28 Hl; multiturn loop antenna of Ohio State University ...31 Configurations ot balanced and unbalanced MTLs ... 32...4. Evaluation of Multiturn Loop Antenna In each example the specific project is outlined and the antenna analysis problems of particular interest

The role of the altruistic unbalanced chain in exchange living donor renal transplantation: single-center experience.

PubMed

Ahn, B K; Kwon, O J; Kang, C M

2012-01-01

The exchange donor program in renal transplantation is an efficient solution for recipients with a blood type or crossmatch-incompatible donor. However, this program has some difficulties to define unacceptable human leukocyte antigen matches, deteriorating clinical potential recipient condition, and withdrawal of donor consent. We analyzed the outcomes of exchange donor renal transplantation through the altruistic unbalanced chain. Among 152 cases of exchange donor renal transplantation from 1991 to 2010 in our hospital, we performed 58 procedures through altruistic unbalanced chains. We compared their outcomes with the direct and balanced chain group. We analyzed retrospectively whether this program expanded the donor pool, seeking better immunologic, size, and age matching. The graft survival and acute rejection rates did not differ significantly in the two groups. Of 152 cases, 58 (38.2%) renal transplantations were performed through an unbalanced chain. Seventeen waiting list recipients were transplanted through an altruistic unbalanced chain. In blood type O recipients (n = 32), the causes of registration in the exchange program were ABO incompatibility (93.3%), and positive crossmatch (6.7%). Nine altruistic blood type O donors and 9 (28.1%) type O recipients underwent transplantations through this chain. We suggest the altruistic unbalanced chain may expand the donor pool with advantages for difficult-to-match pairs. The disadvantages of type O recipients may be overcome through the use of an unbalanced chain. The altruistic unbalanced exchange transplantation program can help easy-to-match subjects, shortening the waiting periods. Copyright © 2012 Elsevier Inc. All rights reserved.

Detection of capacity imbalance in vanadium electrolyte and its electrochemical regeneration for all-vanadium redox-flow batteries

NASA Astrophysics Data System (ADS)

Roznyatovskaya, Nataliya; Herr, Tatjana; Küttinger, Michael; Fühl, Matthias; Noack, Jens; Pinkwart, Karsten; Tübke, Jens

2016-01-01

A vanadium electrolyte for redox-flow batteries (VRFB) with different VIII and VIV mole fractions has been studied by UV-vis spectroscopy. Spectrophotometric detection enables a rough estimate of the VIV and VIII content, which can be used to detect an electrolyte capacity imbalance, i.e. a deviation in the mole fraction of VIV or VIII away from 50%. The isosbestic point at 600 nm can be used as a reference point in the analysis of common VRFB electrolyte batches. The VRFB electrolyte is observed to have an imbalance after prolonged storage (a couple of years) in a tank under ambient conditions. A regeneration procedure, which involves pre-charging the unbalanced electrolyte and mixing part of it with a portion of initial unbalanced electrolyte, has been tested. The resulting rebalanced electrolyte has been compared with a common electrolyte in a charge-discharge cell test and is shown to be suitable for cell operation.

An improved synchronous reference frame current control strategy for a photovoltaic grid-connected inverter under unbalanced and nonlinear load conditions.

PubMed

Naderipour, Amirreza; Asuhaimi Mohd Zin, Abdullah; Bin Habibuddin, Mohd Hafiz; Miveh, Mohammad Reza; Guerrero, Josep M

2017-01-01

In recent years, renewable energy sources have been considered the most encouraging resources for grid and off-grid power generation. This paper presents an improved current control strategy for a three-phase photovoltaic grid-connected inverter (GCI) under unbalanced and nonlinear load conditions. It is challenging to suppress the harmonic content in the output current below a pre-set value in the GCI. It is also difficult to compensate for unbalanced loads even when the grid is under disruption due to total harmonic distortion (THD) and unbalanced loads. The primary advantage and objective of this method is to effectively compensate for the harmonic current content of the grid current and microgrid without the use of any compensation devices, such as active and passive filters. This method leads to a very low THD in both the GCI currents and the current exchanged with the grid. The control approach is designed to control the active and reactive power and harmonic current compensation, and it also corrects the system unbalance. The proposed control method features the synchronous reference frame (SRF) method. Simulation results are presented to demonstrate the effective performance of the proposed method.

An improved synchronous reference frame current control strategy for a photovoltaic grid-connected inverter under unbalanced and nonlinear load conditions

PubMed Central

Naderipour, Amirreza; Asuhaimi Mohd Zin, Abdullah; Bin Habibuddin, Mohd Hafiz; Miveh, Mohammad Reza; Guerrero, Josep M.

2017-01-01

In recent years, renewable energy sources have been considered the most encouraging resources for grid and off-grid power generation. This paper presents an improved current control strategy for a three-phase photovoltaic grid-connected inverter (GCI) under unbalanced and nonlinear load conditions. It is challenging to suppress the harmonic content in the output current below a pre-set value in the GCI. It is also difficult to compensate for unbalanced loads even when the grid is under disruption due to total harmonic distortion (THD) and unbalanced loads. The primary advantage and objective of this method is to effectively compensate for the harmonic current content of the grid current and microgrid without the use of any compensation devices, such as active and passive filters. This method leads to a very low THD in both the GCI currents and the current exchanged with the grid. The control approach is designed to control the active and reactive power and harmonic current compensation, and it also corrects the system unbalance. The proposed control method features the synchronous reference frame (SRF) method. Simulation results are presented to demonstrate the effective performance of the proposed method. PMID:28192436

Re-conceptualizing stress: Shifting views on the consequences of stress and its effects on stress reactivity

PubMed Central

Liu, Jenny J. W.

2017-01-01

Background The consequences of stress are typically regarded from a deficit-oriented approach, conceptualizing stress to be entirely negative in its outcomes. This approach is unbalanced, and may further hinder individuals from engaging in adaptive coping. In the current study, we explored whether negative views and beliefs regarding stress interacted with a stress framing manipulation (positive, neutral and negative) on measures of stress reactivity for both psychosocial and physiological stressors. Method Ninety participants were randomized into one of three framing conditions that conceptualized the experience of stress in balanced, unbalanced-negative or unbalanced-positive ways. After watching a video on stress, participants underwent a psychosocial (Trier Social Stress Test), or a physiological (CO2 challenge) method of stress-induction. Subjective and objective markers of stress were assessed. Results Most of the sampled population regarded stress as negative prior to framing. Further, subjective and objective reactivity were greater to the TSST compared to the CO2 challenge. Additionally, significant cubic trends were observed in the interactions of stress framing and stress-induction methodologies on heart rate and blood pressure. Balanced framing conditions in the TSST group had a significantly larger decrease in heart rate and diastolic blood pressure following stress compared to the positive and negative framing conditions. Conclusion Findings confirmed a deficit-orientation of stress within the sampled population. In addition, results highlighted the relative efficacy of the TSST compared to CO2 as a method of stress provocation. Finally, individuals in framing conditions that posited stress outcomes in unbalanced manners responded to stressors less efficiently. This suggests that unbalanced framing of stress may have set forth unrealistic expectations regarding stress that later hindered individuals from adaptive responses to stress. Potential benefits of alternative conceptualizations of stress on stress reactivity are discussed, and suggestions for future research are made. PMID:28273132

Study of Stand-Alone Microgrid under Condition of Faults on Distribution Line

NASA Astrophysics Data System (ADS)

Malla, S. G.; Bhende, C. N.

2014-10-01

The behavior of stand-alone microgrid is analyzed under the condition of faults on distribution feeders. During fault since battery is not able to maintain dc-link voltage within limit, the resistive dump load control is presented to do so. An inverter control is proposed to maintain balanced voltages at PCC under the unbalanced load condition and to reduce voltage unbalance factor (VUF) at load points. The proposed inverter control also has facility to protect itself from high fault current. Existing maximum power point tracker (MPPT) algorithm is modified to limit the speed of generator during fault. Extensive simulation results using MATLAB/SIMULINK established that the performance of the controllers is quite satisfactory under different fault conditions as well as unbalanced load conditions.

Improved fault ride through capability of DFIG based wind turbines using synchronous reference frame control based dynamic voltage restorer.

PubMed

Rini Ann Jerin, A; Kaliannan, Palanisamy; Subramaniam, Umashankar

2017-09-01

Fault ride through (FRT) capability in wind turbines to maintain the grid stability during faults has become mandatory with the increasing grid penetration of wind energy. Doubly fed induction generator based wind turbine (DFIG-WT) is the most popularly utilized type of generator but highly susceptible to the voltage disturbances in grid. Dynamic voltage restorer (DVR) based external FRT capability improvement is considered. Since DVR is capable of providing fast voltage sag mitigation during faults and can maintain the nominal operating conditions for DFIG-WT. The effectiveness of the DVR using Synchronous reference frame (SRF) control is investigated for FRT capability in DFIG-WT during both balanced and unbalanced fault conditions. The operation of DVR is confirmed using time-domain simulation in MATLAB/Simulink using 1.5MW DFIG-WT. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Crash Frequency Modeling Using Real-Time Environmental and Traffic Data and Unbalanced Panel Data Models

PubMed Central

Chen, Feng; Chen, Suren; Ma, Xiaoxiang

2016-01-01

Traffic and environmental conditions (e.g., weather conditions), which frequently change with time, have a significant impact on crash occurrence. Traditional crash frequency models with large temporal scales and aggregated variables are not sufficient to capture the time-varying nature of driving environmental factors, causing significant loss of critical information on crash frequency modeling. This paper aims at developing crash frequency models with refined temporal scales for complex driving environments, with such an effort providing more detailed and accurate crash risk information which can allow for more effective and proactive traffic management and law enforcement intervention. Zero-inflated, negative binomial (ZINB) models with site-specific random effects are developed with unbalanced panel data to analyze hourly crash frequency on highway segments. The real-time driving environment information, including traffic, weather and road surface condition data, sourced primarily from the Road Weather Information System, is incorporated into the models along with site-specific road characteristics. The estimation results of unbalanced panel data ZINB models suggest there are a number of factors influencing crash frequency, including time-varying factors (e.g., visibility and hourly traffic volume) and site-varying factors (e.g., speed limit). The study confirms the unique significance of the real-time weather, road surface condition and traffic data to crash frequency modeling. PMID:27322306

Analysis of hourly crash likelihood using unbalanced panel data mixed logit model and real-time driving environmental big data.

PubMed

Chen, Feng; Chen, Suren; Ma, Xiaoxiang

2018-06-01

Driving environment, including road surface conditions and traffic states, often changes over time and influences crash probability considerably. It becomes stretched for traditional crash frequency models developed in large temporal scales to capture the time-varying characteristics of these factors, which may cause substantial loss of critical driving environmental information on crash prediction. Crash prediction models with refined temporal data (hourly records) are developed to characterize the time-varying nature of these contributing factors. Unbalanced panel data mixed logit models are developed to analyze hourly crash likelihood of highway segments. The refined temporal driving environmental data, including road surface and traffic condition, obtained from the Road Weather Information System (RWIS), are incorporated into the models. Model estimation results indicate that the traffic speed, traffic volume, curvature and chemically wet road surface indicator are better modeled as random parameters. The estimation results of the mixed logit models based on unbalanced panel data show that there are a number of factors related to crash likelihood on I-25. Specifically, weekend indicator, November indicator, low speed limit and long remaining service life of rutting indicator are found to increase crash likelihood, while 5-am indicator and number of merging ramps per lane per mile are found to decrease crash likelihood. The study underscores and confirms the unique and significant impacts on crash imposed by the real-time weather, road surface, and traffic conditions. With the unbalanced panel data structure, the rich information from real-time driving environmental big data can be well incorporated. Copyright © 2018 National Safety Council and Elsevier Ltd. All rights reserved.

The MSPICE simulation of a saturating transformer

NASA Astrophysics Data System (ADS)

Maclean, David N.

A transformer is simulated using a nonlinear saturating magnetic model. Hysteresis and gradual smooth reduction of core permeability are achieved with standard SPICE networks and functions. The equations that define the nonlinear inductance and the MSPICE circuits used to simulate them are derived. A hierarchy of circuit complexity that is based on the structured logic design subcircuit method is used. An example of a push-pull buck regulator being operated in an unbalanced condition is given. Noise ripple on the input power cable generates a dc offset current in the transformer. The example demonstrates how avionics power equipment can be evaluated for large-signal ac, dc, and transient behavior.

Investigating the ability of shunt hybrid power filter based on SRF method under non-ideal supply voltage

NASA Astrophysics Data System (ADS)

Omran, Mohamed A.; Mohd, Izzeldin I.; Almelian, Mohamad M.; Ullah Sheikh, Usman; Bofares, Mustafa E. A. A.

2018-04-01

This study presents the capacity of a self-tuning filter based on the synchronous reference frame method with a fuzzy logic controller for the improvement of the efficiency of harmonic suppression of a shunt hybrid active power filter in an unbalanced distorted and un-distorted voltage supply conditions. The simulation results indicated that the filter with a fuzzy logic controller had a good filtering performance in steady and transient states, irrespective of whether the voltage supply is distorted or unbalanced.

Load flow and state estimation algorithms for three-phase unbalanced power distribution systems

NASA Astrophysics Data System (ADS)

Madvesh, Chiranjeevi

Distribution load flow and state estimation are two important functions in distribution energy management systems (DEMS) and advanced distribution automation (ADA) systems. Distribution load flow analysis is a tool which helps to analyze the status of a power distribution system under steady-state operating conditions. In this research, an effective and comprehensive load flow algorithm is developed to extensively incorporate the distribution system components. Distribution system state estimation is a mathematical procedure which aims to estimate the operating states of a power distribution system by utilizing the information collected from available measurement devices in real-time. An efficient and computationally effective state estimation algorithm adapting the weighted-least-squares (WLS) method has been developed in this research. Both the developed algorithms are tested on different IEEE test-feeders and the results obtained are justified.

Radio-frequency unbalanced M-Z interferometer for wavelength interrogation of fiber Bragg grating sensors.

PubMed

Zhou, Jiaao; Xia, Li; Cheng, Rui; Wen, Yongqiang; Rohollahnejad, Jalal

2016-01-15

The optical unbalanced Mach-Zehnder interferometer (UMZI) has attracted significant interests for interrogation of FBG sensors owing to its excellent advantages in sensitivity, resolution, and demodulation speed. But this method is still limited to dynamic measurements due to its poor stability and reliability when used for quasi-static detections. Here, we propose for the first time, to the best of our knowledge, a radio-frequency unbalanced M-Z interferometer (RF-UMZI) for interrogation of FBG sensors, which, owing to its operation in an incoherent rather than a coherent regime, provides an ideal solution for the existing stability problem of the conventional UMZI, with remarkable features of adjustable resolution and potentially extremely high sensitivity. A dispersion compensation fiber (DCF) and single-mode fiber (SMF) with a small length difference are served as the two unbalanced arms of the RF interferometer. The induced differential chromatic dispersion transfers the wavelength shift of the FBG to the change of the RF phase difference between the two interferometric carriers, which ultimately leads to the variation of the RF signal intensity. An interrogation of a strain-turned FBG was accomplished and a maximum sensitivity of 0.00835  a.u./με was obtained, which can easily be further improved by more than two orders of magnitude through various fiber dispersion components. Finally, the stability of the interrogation was tested.

Real-space observation of unbalanced charge distribution inside a perovskite-sensitized solar cell.

PubMed

Bergmann, Victor W; Weber, Stefan A L; Javier Ramos, F; Nazeeruddin, Mohammad Khaja; Grätzel, Michael; Li, Dan; Domanski, Anna L; Lieberwirth, Ingo; Ahmad, Shahzada; Berger, Rüdiger

2014-09-22

Perovskite-sensitized solar cells have reached power conversion efficiencies comparable to commercially available solar cells used for example in solar farms. In contrast to silicon solar cells, perovskite-sensitized solar cells can be made by solution processes from inexpensive materials. The power conversion efficiency of these cells depends substantially on the charge transfer at interfaces. Here we use Kelvin probe force microscopy to study the real-space cross-sectional distribution of the internal potential within high efficiency mesoscopic methylammonium lead tri-iodide solar cells. We show that the electric field is homogeneous through these devices, similar to that of a p-i-n type junction. On illumination under short-circuit conditions, holes accumulate in front of the hole-transport layer as a consequence of unbalanced charge transport in the device. After light illumination, we find that trapped charges remain inside the active device layers. Removing these traps and the unbalanced charge injection could enable further improvements in performance of perovskite-sensitized solar cells.

Continuous beer fermentation using immobilized yeast cell bioreactor systems.

PubMed

Brányik, Tomás; Vicente, António A; Dostálek, Pavel; Teixeira, José A

2005-01-01

Traditional beer fermentation and maturation processes use open fermentation and lager tanks. Although these vessels had previously been considered indispensable, during the past decades they were in many breweries replaced by large production units (cylindroconical tanks). These have proved to be successful, both providing operating advantages and ensuring the quality of the final beer. Another promising contemporary technology, namely, continuous beer fermentation using immobilized brewing yeast, by contrast, has found only a limited number of industrial applications. Continuous fermentation systems based on immobilized cell technology, albeit initially successful, were condemned to failure for several reasons. These include engineering problems (excess biomass and problems with CO(2) removal, optimization of operating conditions, clogging and channeling of the reactor), unbalanced beer flavor (altered cell physiology, cell aging), and unrealized cost advantages (carrier price, complex and unstable operation). However, recent development in reactor design and understanding of immobilized cell physiology, together with application of novel carrier materials, could provide a new stimulus to both research and application of this promising technology.

A hybrid clustering approach for multivariate time series - A case study applied to failure analysis in a gas turbine.

PubMed

Fontes, Cristiano Hora; Budman, Hector

2017-11-01

A clustering problem involving multivariate time series (MTS) requires the selection of similarity metrics. This paper shows the limitations of the PCA similarity factor (SPCA) as a single metric in nonlinear problems where there are differences in magnitude of the same process variables due to expected changes in operation conditions. A novel method for clustering MTS based on a combination between SPCA and the average-based Euclidean distance (AED) within a fuzzy clustering approach is proposed. Case studies involving either simulated or real industrial data collected from a large scale gas turbine are used to illustrate that the hybrid approach enhances the ability to recognize normal and fault operating patterns. This paper also proposes an oversampling procedure to create synthetic multivariate time series that can be useful in commonly occurring situations involving unbalanced data sets. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Effects of DC bias on magnetic performance of high grades grain-oriented silicon steels

NASA Astrophysics Data System (ADS)

Ma, Guang; Cheng, Ling; Lu, Licheng; Yang, Fuyao; Chen, Xin; Zhu, Chengzhi

2017-03-01

When high voltage direct current (HVDC) transmission adopting mono-polar ground return operation mode or unbalanced bipolar operation mode, the invasion of DC current into neutral point of alternating current (AC) transformer will cause core saturation, temperature increasing, and vibration acceleration. Based on the MPG-200D soft magnetic measurement system, the influence of DC bias on magnetic performance of 0.23 mm and 0.27 mm series (P1.7=0.70-1.05 W/kg, B8>1.89 T) grain-oriented (GO) silicon steels under condition of AC / DC hybrid excitation were systematically realized in this paper. For the high magnetic induction GO steels (core losses are the same), greater thickness can lead to stronger ability of resisting DC bias, and the reasons for it were analyzed. Finally, the magnetostriction and A-weighted magnetostriction velocity level of GO steel under DC biased magnetization were researched.

An AUC-based permutation variable importance measure for random forests

PubMed Central

2013-01-01

Background The random forest (RF) method is a commonly used tool for classification with high dimensional data as well as for ranking candidate predictors based on the so-called random forest variable importance measures (VIMs). However the classification performance of RF is known to be suboptimal in case of strongly unbalanced data, i.e. data where response class sizes differ considerably. Suggestions were made to obtain better classification performance based either on sampling procedures or on cost sensitivity analyses. However to our knowledge the performance of the VIMs has not yet been examined in the case of unbalanced response classes. In this paper we explore the performance of the permutation VIM for unbalanced data settings and introduce an alternative permutation VIM based on the area under the curve (AUC) that is expected to be more robust towards class imbalance. Results We investigated the performance of the standard permutation VIM and of our novel AUC-based permutation VIM for different class imbalance levels using simulated data and real data. The results suggest that the new AUC-based permutation VIM outperforms the standard permutation VIM for unbalanced data settings while both permutation VIMs have equal performance for balanced data settings. Conclusions The standard permutation VIM loses its ability to discriminate between associated predictors and predictors not associated with the response for increasing class imbalance. It is outperformed by our new AUC-based permutation VIM for unbalanced data settings, while the performance of both VIMs is very similar in the case of balanced classes. The new AUC-based VIM is implemented in the R package party for the unbiased RF variant based on conditional inference trees. The codes implementing our study are available from the companion website: http://www.ibe.med.uni-muenchen.de/organisation/mitarbeiter/070_drittmittel/janitza/index.html. PMID:23560875

An AUC-based permutation variable importance measure for random forests.

PubMed

Janitza, Silke; Strobl, Carolin; Boulesteix, Anne-Laure

2013-04-05

The random forest (RF) method is a commonly used tool for classification with high dimensional data as well as for ranking candidate predictors based on the so-called random forest variable importance measures (VIMs). However the classification performance of RF is known to be suboptimal in case of strongly unbalanced data, i.e. data where response class sizes differ considerably. Suggestions were made to obtain better classification performance based either on sampling procedures or on cost sensitivity analyses. However to our knowledge the performance of the VIMs has not yet been examined in the case of unbalanced response classes. In this paper we explore the performance of the permutation VIM for unbalanced data settings and introduce an alternative permutation VIM based on the area under the curve (AUC) that is expected to be more robust towards class imbalance. We investigated the performance of the standard permutation VIM and of our novel AUC-based permutation VIM for different class imbalance levels using simulated data and real data. The results suggest that the new AUC-based permutation VIM outperforms the standard permutation VIM for unbalanced data settings while both permutation VIMs have equal performance for balanced data settings. The standard permutation VIM loses its ability to discriminate between associated predictors and predictors not associated with the response for increasing class imbalance. It is outperformed by our new AUC-based permutation VIM for unbalanced data settings, while the performance of both VIMs is very similar in the case of balanced classes. The new AUC-based VIM is implemented in the R package party for the unbiased RF variant based on conditional inference trees. The codes implementing our study are available from the companion website: http://www.ibe.med.uni-muenchen.de/organisation/mitarbeiter/070_drittmittel/janitza/index.html.

Genetics Home Reference: HIVEP2-related intellectual disability

MedlinePlus

... to have difficulty with this activity; their walking style (gait) is often unbalanced and wide-based. Speech ... be inherited? More about Inheriting Genetic Conditions Diagnosis & Management Resources General Information from MedlinePlus (5 links) Diagnostic ...

Usefulness of left ventricular inflow index to predict successful biventricular repair in right-dominant unbalanced atrioventricular canal.

PubMed

Szwast, Anita L; Marino, Bradley S; Rychik, Jack; Gaynor, James William; Spray, Thomas L; Cohen, Meryl S

2011-01-01

The outcome of biventricular (BV) repair for right-dominant unbalanced atrioventricular canal has remained poor, because it is difficult to predict left ventricular (LV) adequacy before surgery. Our aim was to determine whether preoperative echocardiographic parameters, specifically analysis of color inflow into the LV, would predict survival after BV repair in patients with right-dominant unbalanced atrioventricular canal. Subjects with right-dominant unbalanced atrioventricular canal diagnosed from 1994 to 2007 were included. The echocardiographic parameters were analyzed blinded to the palliation strategy and survival. The LV inflow index (LVII) was calculated as the secondary color inflow diameter indexed to the left atrioventricular valve (AVV) annulus diameter. Univariate analysis, survival analysis, and multivariate modeling with stepwise logistic regression were performed. Of the 45 subjects, 23 (51%) underwent single ventricle (SV) palliation and 22 (49%) underwent BV repair. Of the 23 who underwent SV palliation, 15 (65%) survived compared to 18 (82%) of 22 who underwent BV repair (p = 0.34). In the BV group, a greater LVII predicted survival (R2 = 0.46, p = 0.03). No subjects with a LVII <0.5 survived BV repair. Mortality in the BV group was associated with younger age at initial surgery (p <0.01) and abnormal left AVV morphology (p = 0.02). Of the BV subjects with a patent ductus arteriosus at the initial operation (n = 11), the nonsurvivors were more likely to have retrograde flow in the transverse arch (p <0.01). In the BV group, reoperation within 30 days of the initial repair was strongly associated with mortality (p <0.01). In conclusion, in cases of mild or moderate LV hypoplasia, a greater LVII predicted survival after BV repair in patients with right-dominant unbalanced atrioventricular canal. We propose incorporation of the LVII into the echocardiographic assessment of these patients. Copyright © 2011 Elsevier Inc. All rights reserved.

System having unmodulated flux locked loop for measuring magnetic fields

DOEpatents

Ganther, Jr., Kenneth R.; Snapp, Lowell D [Blue Springs, MO

2006-08-15

A system (10) for measuring magnetic fields, wherein the system (10) comprises an unmodulated or direct-feedback flux locked loop (12) connected by first and second unbalanced RF coaxial transmission lines (16a, 16b) to a superconducting quantum interference device (14). The FLL (12) operates for the most part in a room-temperature or non-cryogenic environment, while the SQUID (14) operates in a cryogenic environment, with the first and second lines (16a, 16b) extending between these two operating environments.

New low-level a-c amplifier provides adjustable noise cancellation and automatic temperature compensation

NASA Technical Reports Server (NTRS)

Smith, J. R., Jr.

1964-01-01

Circuit utilizing a transistorized differential amplifier is developed for biomedical use. This low voltage operating circuit provides adjustable cancellation at the input for unbalanced noise signals, and automatic temperature compensation is accomplished by a single active element across the input-output ends.

In-Process Quality Control in Apparel Production: Sewing Defects

DTIC Science & Technology

1991-10-01

runout 2. unbalanced stitch, stitch length variation Operator: 1. Raw edge, ply misalignment, sewing off of garment Thread: 1. Thread damage, broken...sewing machine. Two measurements were made for each position of the handwheel. The method used for marking the wheel is described below. A special tape

Amelioration de la qualite d'energie d'un systeme de conversion d'energie eolienne a base de machine asynchrone a double alimentation et connecte au reseau electrique =

NASA Astrophysics Data System (ADS)

Abderrahim, Iheb

Wind power generation has grown strongly in the last decade. This results in the development of Wind Energy Conversion System WECS at the levels of modeling and electrical control. Modern WECS operate at varying wind speeds and are equipped with synchronous and asynchronous generators. Among these generators, the Doubly-Fed Induction Generator (DFIG) offers several advantages and capabilities of active and reactive power in four quadrants. WECS based DFIG also causes less conversion costs and minimum energy losses compared with a WECS based on a synchronous generator powered entirely by full scale of power converters. The connection of such a system to the electrical distribution network involves bidirectional operation of networks. This is clearly established in sub and super synchronous operating modes of DFIG. The grid provides the active power to the rotor of DFIG in sub synchronous operating mode and receives the active power of the rotor in super synchronous operating mode of DFIG. Energy quality is thus of major importance during the integration of wind power to the grid. Poor wave quality can affect network stability and could even cause major problems and consequences. This is even more critical where non-linear loads such as the switching power supplies and variable speed drives, are connected to the grid. The idea of this research work is how to mitigate the problems associated with the wave quality while ensuring better implementation of DFIG so that the whole of WECS remains insensitive to external disturbances and parametric variations. The Grid Side Converter (GSC) must be able to compensate harmonics, current unbalance and reactive power injected by a nonlinear three-phase unbalanced load connected to the grid. In addition to these innovative features to improve the conditions of operation of the grid, it provides also the power flow during different modes of operation of the DFIG. It is considered a simple, efficient and cost competitive solution by saving the use of other power equipment. At the same time, the energy efficiency of wind power conversion chain should be improved by extracting the MPPT. Searching allows us to select vector control and control in synchronous reference to achieve these objectives. WECS based DFIG is simulated in MATLAB SIMULINK in the presence of a non-linear balanced and unbalanced three-phase load.

A Standardised Abundance Index from Commercial Spotting Data of Southern Bluefin Tuna (Thunnus maccoyii): Random Effects to the Rescue

PubMed Central

Basson, Marinelle; Farley, Jessica H.

2014-01-01

Commercial aerial spotting of surface schools of juvenile southern bluefin tuna (SBT), Thunnus maccoyii, is conducted as part of fishing operations in the Great Australian Bight in summer. This provides the opportunity to efficiently collect large amounts of data on sightings of SBT. The data can potentially be used to construct a time-series index of relative abundance by standardising the data for issues such as weather, spotter ability and ocean conditions. Unlike a statistically designed survey, the commercial spotting is governed by business considerations and fishing operations. The SBT dataset is therefore highly unbalanced with regard to spotters operating in each season. This complicates the standardisation of the data, particularly with regard to interactions between covariates. We show how a generalized additive model with random effects can simplify both the fitting of the model and the construction of an index, while also avoiding the need to leave out strata or interaction terms that are important. The approach is applicable to standardisation of more traditional catch and effort data. PMID:25541730

A standardised abundance index from commercial spotting data of southern bluefin tuna (Thunnus maccoyii): random effects to the rescue.

PubMed

Basson, Marinelle; Farley, Jessica H

2014-01-01

Commercial aerial spotting of surface schools of juvenile southern bluefin tuna (SBT), Thunnus maccoyii, is conducted as part of fishing operations in the Great Australian Bight in summer. This provides the opportunity to efficiently collect large amounts of data on sightings of SBT. The data can potentially be used to construct a time-series index of relative abundance by standardising the data for issues such as weather, spotter ability and ocean conditions. Unlike a statistically designed survey, the commercial spotting is governed by business considerations and fishing operations. The SBT dataset is therefore highly unbalanced with regard to spotters operating in each season. This complicates the standardisation of the data, particularly with regard to interactions between covariates. We show how a generalized additive model with random effects can simplify both the fitting of the model and the construction of an index, while also avoiding the need to leave out strata or interaction terms that are important. The approach is applicable to standardisation of more traditional catch and effort data.

Gross regional domestic product estimation: Application of two-way unbalanced panel data models to economic growth in East Nusa Tenggara province

NASA Astrophysics Data System (ADS)

Wibowo, Wahyu; Sinu, Elisabeth B.; Setiawan

2017-03-01

The condition of East Nusa Tenggara Province which recently developed new districts can affect the number of information or data collected become unbalanced. One of the consequences of ignoring the data incompleteness is the estimator become not valid. Therefore, the analysis of unbalanced panel data is very crucial.The aim of this paper is to find the estimation of Gross Regional Domestic Product in East Nusa Tenggara Province using unbalanced panel data regression model for two-way error component which assume random effect model (REM). In this research, we employ Feasible Generalized Least Squares (FGLS) as regression coefficients estimation method. Since variance of the model is unknown, ANOVA method is considered to obtain the variance components in order to construct the variance-covariance matrix. The data used in this research is secondary data taken from Central Bureau of Statistics of East Nusa Tenggara Province in 21 districts period 2004-2013. The predictors are the number of labor over 15 years old (X1), electrification ratios (X2), and local revenues (X3) while Gross Regional Domestic Product based on constant price 2000 is the response (Y). The FGLS estimation result shows that the value of R2 is 80,539% and all the predictors chosen are significantly affect (α = 5%) the Gross Regional Domestic Product in all district of East Nusa Tenggara Province. Those variables are the number of labor over 15 years old (X1), electrification ratios (X2), and local revenues (X3) with 0,22986, 0,090476, and 0,14749 of elasticities, respectively.

Adaptive Harmonic Detection Control of Grid Interfaced Solar Photovoltaic Energy System with Power Quality Improvement

NASA Astrophysics Data System (ADS)

Singh, B.; Goel, S.

2015-03-01

This paper presents a grid interfaced solar photovoltaic (SPV) energy system with a novel adaptive harmonic detection control for power quality improvement at ac mains under balanced as well as unbalanced and distorted supply conditions. The SPV energy system is capable of compensation of linear and nonlinear loads with the objectives of load balancing, harmonics elimination, power factor correction and terminal voltage regulation. The proposed control increases the utilization of PV infrastructure and brings down its effective cost due to its other benefits. The adaptive harmonic detection control algorithm is used to detect the fundamental active power component of load currents which are subsequently used for reference source currents estimation. An instantaneous symmetrical component theory is used to obtain instantaneous positive sequence point of common coupling (PCC) voltages which are used to derive inphase and quadrature phase voltage templates. The proposed grid interfaced PV energy system is modelled and simulated in MATLAB Simulink and its performance is verified under various operating conditions.

Characteristic investigation and control of a modular multilevel converter-based HVDC system under single-line-to-ground fault conditions

DOE PAGES

Shi, Xiaojie; Wang, Zhiqiang; Liu, Bo; ...

2014-05-16

This paper presents the analysis and control of a multilevel modular converter (MMC)-based HVDC transmission system under three possible single-line-to-ground fault conditions, with special focus on the investigation of their different fault characteristics. Considering positive-, negative-, and zero-sequence components in both arm voltages and currents, the generalized instantaneous power of a phase unit is derived theoretically according to the equivalent circuit model of the MMC under unbalanced conditions. Based on this model, a novel double-line frequency dc-voltage ripple suppression control is proposed. This controller, together with the negative-and zero-sequence current control, could enhance the overall fault-tolerant capability of the HVDCmore » system without additional cost. To further improve the fault-tolerant capability, the operation performance of the HVDC system with and without single-phase switching is discussed and compared in detail. Lastly, simulation results from a three-phase MMC-HVDC system generated with MATLAB/Simulink are provided to support the theoretical analysis and proposed control schemes.« less

Power Analysis in Two-Level Unbalanced Designs

ERIC Educational Resources Information Center

Konstantopoulos, Spyros

2010-01-01

Previous work on statistical power has discussed mainly single-level designs or 2-level balanced designs with random effects. Although balanced experiments are common, in practice balance cannot always be achieved. Work on class size is one example of unbalanced designs. This study provides methods for power analysis in 2-level unbalanced designs…

New heterogeneous test statistics for the unbalanced fixed-effect nested design.

PubMed

Guo, Jiin-Huarng; Billard, L; Luh, Wei-Ming

2011-05-01

When the underlying variances are unknown or/and unequal, using the conventional F test is problematic in the two-factor hierarchical data structure. Prompted by the approximate test statistics (Welch and Alexander-Govern methods), the authors develop four new heterogeneous test statistics to test factor A and factor B nested within A for the unbalanced fixed-effect two-stage nested design under variance heterogeneity. The actual significance levels and statistical power of the test statistics were compared in a simulation study. The results show that the proposed procedures maintain better Type I error rate control and have greater statistical power than those obtained by the conventional F test in various conditions. Therefore, the proposed test statistics are recommended in terms of robustness and easy implementation. ©2010 The British Psychological Society.

Obesity and the Unbalanced Energy Equation: Exercise versus Eating Habit Change.

ERIC Educational Resources Information Center

And Others; Dahlkoetter, JoAnn

1979-01-01

Compared relative effectiveness of exercise and eating habit change individually and in combination for weight loss and physical conditioning. Results indicated significant improvement for all treatment groups. Groups who exercised showed most improvement in physical fitness. Combining exercise and eating habit change yielded best results in…

Genotype by environment interaction and the use of unbalanced historical data for genomic selection in an international wheat breeding program

USDA-ARS?s Scientific Manuscript database

Genomic selection (GS) offers breeders the possibility of using historic data and unbalanced breeding trials to form training populations for predicting the performance of new lines. However, in using datasets that are unbalanced over time and space, there is increasing exposure to particular genoty...

76 FR 54824 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Order Approving Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-02

... Federal Reserve Bank of New York.\\4\\ Because the GCF Repo service operates as a tri-party repo mechanism... that GSCC would likely have unbalanced net GCF securities and cash positions within each clearing bank... clearing bank will be net funds borrowers, while the dealers at the other clearing bank will be net funds...

Recent advances in Li/SO2 battery technology

NASA Astrophysics Data System (ADS)

Ralston, R. E.

The areas of improvement discussed are related to cell closure-hermetic seals, improved glass-to-metal seals, and lithium-limited cell design. Attention is given to the design of a Li/SO2 cell which can safely withstand discharge below zero volts into voltage reversal. The design characteristics of an unbalanced cell, the new lithium-limited or balanced cell, and a high rate unbalanced design are compared in a table for the 'D' size cell. It is concluded that the improvements in cell closure, glass seal stability, and cell balance have resulted in storability, reliability, and abuse resistance characteristics which make the performance of today's Li/SO2 battery without equal among competitive primary batteries. However, the Li/SO2 cell must not be used in applications where extreme electrical or environmental conditions can push the system beyond its recommended limits.

International Migration, Deindustrialization and Union Decline in 16 Affluent OECD Countries, 1962-1997

ERIC Educational Resources Information Center

Lee, Cheol-Sung

2005-01-01

This article, using unbalanced panel data on 16 affluent OECD countries, tests the effects of diverse aspects of globalization and deindustrialization on unionization trends. In contrast to the recent studies focusing on the conditional role of labor market institutions, this study underlines the role of two structural factors in transforming…

Fast, optically controlled Kerr phase shifter for digital signal processing.

PubMed

Li, R B; Deng, L; Hagley, E W; Payne, M G; Bienfang, J C; Levine, Z H

2013-05-01

We demonstrate an optically controlled Kerr phase shifter using a room-temperature 85Rb vapor operating in a Raman gain scheme. Phase shifts from zero to π relative to an unshifted reference wave are observed, and gated operations are demonstrated. We further demonstrate the versatile digital manipulation of encoded signal light with an encoded phase-control light field using an unbalanced Mach-Zehnder interferometer. Generalizations of this scheme should be capable of full manipulation of a digitized signal field at high speed, opening the door to future applications.

Determination of Charge-Carrier Mobility in Disordered Thin-Film Solar Cells as a Function of Current Density

NASA Astrophysics Data System (ADS)

Mäckel, Helmut; MacKenzie, Roderick C. I.

2018-03-01

Charge-carrier mobility is a fundamental material parameter, which plays an important role in determining solar-cell efficiency. The higher the mobility, the less time a charge carrier will spend in a device and the less likely it is that it will be lost to recombination. Despite the importance of this physical property, it is notoriously difficult to measure accurately in disordered thin-film solar cells under operating conditions. We, therefore, investigate a method previously proposed in the literature for the determination of mobility as a function of current density. The method is based on a simple analytical model that relates the mobility to carrier density and transport resistance. By revising the theoretical background of the method, we clearly demonstrate what type of mobility can be extracted (constant mobility or effective mobility of electrons and holes). We generalize the method to any combination of measurements that is able to determine the mean electron and hole carrier density, and the transport resistance at a given current density. We explore the robustness of the method by simulating typical organic solar-cell structures with a variety of physical properties, including unbalanced mobilities, unbalanced carrier densities, and for high or low carrier trapping rates. The simulations reveal that near VOC and JSC , the method fails due to the limitation of determining the transport resistance. However, away from these regions (and, importantly, around the maximum power point), the method can accurately determine charge-carrier mobility. In the presence of strong carrier trapping, the method overestimates the effective mobility due to an underestimation of the carrier density.

High speed ultra-broadband amplitude modulators with ultrahigh extinction >65 dB.

PubMed

Liu, S; Cai, H; DeRose, C T; Davids, P; Pomerene, A; Starbuck, A L; Trotter, D C; Camacho, R; Urayama, J; Lentine, A

2017-05-15

We experimentally demonstrate ultrahigh extinction ratio (>65 dB) amplitude modulators (AMs) that can be electrically tuned to operate across a broad spectral range of 160 nm from 1480 - 1640 nm and 95 nm from 1280 - 1375 nm. Our on-chip AMs employ one extra coupler compared with conventional Mach-Zehnder interferometers (MZI), thus form a cascaded MZI (CMZI) structure. Either directional or adiabatic couplers are used to compose the CMZI AMs and experimental comparisons are made between these two different structures. We investigate the performance of CMZI AMs under extreme conditions such as using 95:5 split ratio couplers and unbalanced waveguide losses. Electro-optic phase shifters are also integrated in the CMZI AMs for high-speed operation. Finally, we investigate the output optical phase when the amplitude is modulated, which provides us valuable information when both amplitude and phase are to be controlled. Our demonstration not only paves the road to applications such as quantum information processing that requires high extinction ratio AMs but also significantly alleviates the tight fabrication tolerance needed for large-scale integrated photonics.

Evaluation of performance of a BLSS model in long-term operation in dynamic and steady states

NASA Astrophysics Data System (ADS)

Gros, Jean-Bernard; Tikhomirov, Alex; Ushakova, Sofya; Velitchko, Vladimir; Tikhomirova, Natalia; Lasseur, Christophe

Evaluation of performance of a BLSS model, including higher plants for food production and biodegradation of human waste, in long-term operation in dynamic and steady states was performed. The model system was conceived for supplying vegetarian food and oxygen to 0.07 human. The following data were obtained in steady-state operating conditions. Average rate of wheat, chufa, radish, lettuce and Salicornia edible biomass accumulation were 8.7, 5.5, 0.6, 0.6 and metricconverterProductID2.5 g2.5 g per day respectively. Thus, to mimic the vegetarian edible biomass consumption by a human it was necessary to withdraw 17.9 g/d from total mass ex-change. Simultaneously, human mineralized exometabolites (artificial mineralized urine, AMU) in the amount of approximately 7% of a daily norm were introduced into the nutrient solu-tion for irrigation of the plants cultivated on a neutral substrate (expanded clay aggregate). The estimated value of 5.8 g/d of wheat and Salicornia inedible biomass was introduced in the soil-like substrate (SLS) to fully meet the plants need in nitrogen. The rest of wheat and Salicornia inedible biomass, 5.7 g/d, was stored. Thus in all, 23.6g of vegetarian dry matter had been stored. Assuming edible biomass is eaten up by the human, the closure coefficient of the vegetarian biomass inclusion into matter recycling amounted to 88%. The analysis of the long-term model operation showed that the main factors limiting increase of recycling processes were the following: a) Partly unbalanced mineral composition of daily human waste with daily needs of plants culti-` vated in the system. Thus, when fully satisfied with respect to nitrogen, the plants experienced a lack of macro elements such as P, Mg and Ca by more than 50%; b) Partly unbalanced mineral composition of edible biomass of the plants cultivated in the SLS with that of inedible biomass of the plants cultivated by hydroponic method on neutral substrate introduced in the SLS; c) Accumulation of some salts, for example, calcium and phosphorus salts resulting in their inaccessibility for the plant root nutrition; d) Allelopathic effect of chufa inedible biomass on the growth and development of other plants which decreases their productivity.

A Line Impedance Conditioner for Saturation Mitigation of Zigzag Transformer in Hybrid AC/DC Transmission System Considering Line Unbalances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Bo; Shi, Xiaojie M.; Li, Yalong

Hybrid ac/dc transmission extends the power transfer capacity of existing long ac lines closer to their thermal limit, by superposing the dc current onto three-phase ac lines through a zigzag transformer. However, this transformer could suffer saturation under unbalanced line impedance conditions. This paper introduces the concept of hybrid line impedance conditioner (HLIC) as a cost-effective approach to compensate for the line unbalance and therefore avoid saturation. The topology and operation principle are presented. The two-level control strategy is described, which enables autonomous adaptive regulation without the need of system-level control. Design and implementation are also analyzed, including dc-link capacitancemore » as one of the key line conditioner components, HLIC installation, and protection under fault conditions. The cost study on this HLIC-based hybrid system is also performed to reveal the benefits of the solution. In conclusion, simulation results and experimental results based on a down-scaled prototype are provided to verify the feasibility of the proposed approach.« less

A Line Impedance Conditioner for Saturation Mitigation of Zigzag Transformer in Hybrid AC/DC Transmission System Considering Line Unbalances

DOE PAGES

Liu, Bo; Shi, Xiaojie M.; Li, Yalong; ...

2016-09-13

Hybrid ac/dc transmission extends the power transfer capacity of existing long ac lines closer to their thermal limit, by superposing the dc current onto three-phase ac lines through a zigzag transformer. However, this transformer could suffer saturation under unbalanced line impedance conditions. This paper introduces the concept of hybrid line impedance conditioner (HLIC) as a cost-effective approach to compensate for the line unbalance and therefore avoid saturation. The topology and operation principle are presented. The two-level control strategy is described, which enables autonomous adaptive regulation without the need of system-level control. Design and implementation are also analyzed, including dc-link capacitancemore » as one of the key line conditioner components, HLIC installation, and protection under fault conditions. The cost study on this HLIC-based hybrid system is also performed to reveal the benefits of the solution. In conclusion, simulation results and experimental results based on a down-scaled prototype are provided to verify the feasibility of the proposed approach.« less

Data Normalization of (1)H NMR Metabolite Fingerprinting Data Sets in the Presence of Unbalanced Metabolite Regulation.

PubMed

Hochrein, Jochen; Zacharias, Helena U; Taruttis, Franziska; Samol, Claudia; Engelmann, Julia C; Spang, Rainer; Oefner, Peter J; Gronwald, Wolfram

2015-08-07

Data normalization is an essential step in NMR-based metabolomics. Conducted properly, it improves data quality and removes unwanted biases. The choice of the appropriate normalization method is critical and depends on the inherent properties of the data set in question. In particular, the presence of unbalanced metabolic regulation, where the different specimens and cohorts under investigation do not contain approximately equal shares of up- and down-regulated features, may strongly influence data normalization. Here, we demonstrate the suitability of the Shapiro-Wilk test to detect such unbalanced regulation. Next, employing a Latin-square design consisting of eight metabolites spiked into a urine specimen at eight different known concentrations, we show that commonly used normalization and scaling methods fail to retrieve true metabolite concentrations in the presence of increasing amounts of glucose added to simulate unbalanced regulation. However, by learning the normalization parameters on a subset of nonregulated features only, Linear Baseline Normalization, Probabilistic Quotient Normalization, and Variance Stabilization Normalization were found to account well for different dilutions of the samples without distorting the true spike-in levels even in the presence of marked unbalanced metabolic regulation. Finally, the methods described were applied successfully to a real world example of unbalanced regulation, namely, a set of plasma specimens collected from patients with and without acute kidney injury after cardiac surgery with cardiopulmonary bypass use.

Why Does Rebalancing Class-Unbalanced Data Improve AUC for Linear Discriminant Analysis?

PubMed

Xue, Jing-Hao; Hall, Peter

2015-05-01

Many established classifiers fail to identify the minority class when it is much smaller than the majority class. To tackle this problem, researchers often first rebalance the class sizes in the training dataset, through oversampling the minority class or undersampling the majority class, and then use the rebalanced data to train the classifiers. This leads to interesting empirical patterns. In particular, using the rebalanced training data can often improve the area under the receiver operating characteristic curve (AUC) for the original, unbalanced test data. The AUC is a widely-used quantitative measure of classification performance, but the property that it increases with rebalancing has, as yet, no theoretical explanation. In this note, using Gaussian-based linear discriminant analysis (LDA) as the classifier, we demonstrate that, at least for LDA, there is an intrinsic, positive relationship between the rebalancing of class sizes and the improvement of AUC. We show that the largest improvement of AUC is achieved, asymptotically, when the two classes are fully rebalanced to be of equal sizes.

Use of unbalanced laminates as a screening method for microcracking

NASA Technical Reports Server (NTRS)

Papadopoulos, Demetrios S.; Bowles, Kenneth J.

1990-01-01

State-of-the-art, high temperature polyimide matrix composites, reinforced with continuous graphite fibers are known to be susceptible to intraply cracking when thermally cycled over their useful service temperature range. It is believed that the transply cracking, in part, results from residual stresses caused by differences in coefficients of thermal expansion (CTE) between the polymer matrix and the reinforcement. Thermal cycling tests to investigate this phenomenon involve expensive time and energy consuming programs which are not economically feasible for use as a part of a materials screening process. As an alternative to thermal cycling studies, a study of unbalanced crossply graphite fiber reinforcement composites was conducted to assess the effect of the composite ply layup and surface condition on the residual stresses that remain after the processing of these materials. The residual stresses were assessed by measuring the radii of curvature of the types of laminates that were studied. The temperature at which stress-free conditions existed were determined and a dye penetrant method was used to observe surface damage resulting from excessive residual stress buildup. These results are compared with some published results of thermal cycling tests that were previously conducted on balanced polyimide composites.

Unbalanced atrioventricular septal defect: definition and decision making.

PubMed

Overman, David M; Baffa, Jeanne M; Cohen, Meryl S; Mertens, Luc; Gremmels, David B; Jegatheeswaram, Anusha; McCrindle, Brian W; Blackstone, Eugene H; Morell, Victor O; Caldarone, Christopher; Williams, William G; Pizarro, Christian

2010-04-01

Unbalanced atrioventricular septal defect is an uncommon lesion with widely varying anatomic manifestations. When unbalance is severe, diagnosis and treatment is straightforward, directed toward single-ventricle palliation. Milder forms, however, pose a challenge to current diagnostic and therapeutic approaches. The transition from anatomies that are capable of sustaining biventricular physiology to those that cannot is obscure, resulting in uneven application of surgical strategy and excess mortality. Imprecise assessments of ventricular competence have dominated clinical decision making in this regard. Malalignment of the atrioventricular junction and its attendant derangement of inflow physiology is a critical factor in determining the feasibility of biventricular repair in the setting of unbalanced atrioventricular septal defect. The atrioventricular valve index accurately identifies unbalanced atrioventricular septal defect and also brings into focus a zone of transition from anatomies that can support a biventricular end state and those that cannot.

Unbalanced and Minimal Point Equivalent Estimation Second-Order Split-Plot Designs

NASA Technical Reports Server (NTRS)

Parker, Peter A.; Kowalski, Scott M.; Vining, G. Geoffrey

2007-01-01

Restricting the randomization of hard-to-change factors in industrial experiments is often performed by employing a split-plot design structure. From an economic perspective, these designs minimize the experimental cost by reducing the number of resets of the hard-to- change factors. In this paper, unbalanced designs are considered for cases where the subplots are relatively expensive and the experimental apparatus accommodates an unequal number of runs per whole-plot. We provide construction methods for unbalanced second-order split- plot designs that possess the equivalence estimation optimality property, providing best linear unbiased estimates of the parameters; independent of the variance components. Unbalanced versions of the central composite and Box-Behnken designs are developed. For cases where the subplot cost approaches the whole-plot cost, minimal point designs are proposed and illustrated with a split-plot Notz design.

Altruistic unbalanced paired kidney exchange at Columbia University/New York-Presbyterian hospital: rationale and practical considerations.

PubMed

Ratner, Lloyd E; Ratner, Emily R; Kelly, Joan; Carrol, Maureen; Cherwinski, Karyn; Ernst, Victoria; Rana, Abbas

2008-01-01

Paired kidney exchanges are being used with increasing frequency to overcome humoral immunologic incompatibilities between patients in need of renal transplantation and their potential live donors. Altruistic unbalanced exchanges utilize compatible donor/recipient pairs in order to facilitate the transplantation of a patient with an incompatible donor. We have now performed several altruistic unbalanced paired kidney exchanges at our institution. Also, we have surveyed potential donors and recipients regarding their attitudes toward participating in altruistic unbalanced paired kidney exchanges. Patients are most amenable to participation if they perceive a benefit from trading away a compatible donor. Given the number of compatible live donor transplants performed annually, if practiced on a broad scale, altruistic unbalancedpaired kidney exchanges can have a profound impact upon the supply of kidneys for transplantation. These exchanges can be performed at individual centers without the requirement for largesharing pools or complex computer algorithms. However, there are a number of ethical and logistical considerations that must be addressed. Altruistic unbalanced paired kidney exchanges represent a major paradigm shift in renal transplantation, in that a private resource (i.e. the live kidney donor) is converted to a shared or public one.

TRANSFORMER FOR JOINING UNBALANCED TO BALANCED TRANSMISSION MEANS

DOEpatents

Bittner, B.J.; Opperman, R.H.

1960-06-28

An improved transformer is invented for joining an unbalanced transmission means to a balanced transmission means and is useful, for example, in transmitting an electromagnetic signal from a coaxial cable to a balanced dipole antenna.

Implementation of a Balance Operator in NCOM

DTIC Science & Technology

2016-04-07

the background temperature Tb and salinity Sb fields do), f is the Coriolis parameter, k is the vertical unit vector, ∇ is the horizontal gradient, p... effectively used as a natural metric in the space of cost function gradients. The associated geometry inhibits descent in the unbalanced directions...28) where f is the local Coriolis parameter, ∆yv is the local grid spacing in the y direction at a v point, and the overbars indicates horizontal

Unbalanced Stability: Applying Lessons from American Cities in Stability Operations

DTIC Science & Technology

2011-05-19

teenagers congregating on street corners, public solicitation for prostitution, begging, public drinking, verbal harassment of women on the street, and...United Nations Security Council, “United Nations Security Council Resolution 1590 (2005).” http://www.un.org/ga/search/view_doc.asp?symbol=S/RES/ 1590 (2005...Security Council. “United Nations Security Council Resolution 1590 (2005).” United Nations. http://www.un.org/ga/search/view_doc.asp?symbol=S/RES/ 1590

Characteristics of Low-latitude Coronal Holes near the Maximum of Solar Cycle 24

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofmeister, Stefan J.; Veronig, Astrid; Reiss, Martin A.

We investigate the statistics of 288 low-latitude coronal holes extracted from SDO /AIA-193 filtergrams over the time range of 2011 January 01–2013 December 31. We analyze the distribution of characteristic coronal hole properties, such as the areas, mean AIA-193 intensities, and mean magnetic field densities, the local distribution of the SDO /AIA-193 intensity and the magnetic field within the coronal holes, and the distribution of magnetic flux tubes in coronal holes. We find that the mean magnetic field density of all coronal holes under study is 3.0 ± 1.6 G, and the percentaged unbalanced magnetic flux is 49 ± 16%.more » The mean magnetic field density, the mean unsigned magnetic field density, and the percentaged unbalanced magnetic flux of coronal holes depend strongly pairwise on each other, with correlation coefficients cc > 0.92. Furthermore, we find that the unbalanced magnetic flux of the coronal holes is predominantly concentrated in magnetic flux tubes: 38% (81%) of the unbalanced magnetic flux of coronal holes arises from only 1% (10%) of the coronal hole area, clustered in magnetic flux tubes with field strengths >50 G (10 G). The average magnetic field density and the unbalanced magnetic flux derived from the magnetic flux tubes correlate with the mean magnetic field density and the unbalanced magnetic flux of the overall coronal hole (cc>0.93). These findings give evidence that the overall magnetic characteristics of coronal holes are governed by the characteristics of the magnetic flux tubes.« less

Improved score statistics for meta-analysis in single-variant and gene-level association studies.

PubMed

Yang, Jingjing; Chen, Sai; Abecasis, Gonçalo

2018-06-01

Meta-analysis is now an essential tool for genetic association studies, allowing them to combine large studies and greatly accelerating the pace of genetic discovery. Although the standard meta-analysis methods perform equivalently as the more cumbersome joint analysis under ideal settings, they result in substantial power loss under unbalanced settings with various case-control ratios. Here, we investigate the power loss problem by the standard meta-analysis methods for unbalanced studies, and further propose novel meta-analysis methods performing equivalently to the joint analysis under both balanced and unbalanced settings. We derive improved meta-score-statistics that can accurately approximate the joint-score-statistics with combined individual-level data, for both linear and logistic regression models, with and without covariates. In addition, we propose a novel approach to adjust for population stratification by correcting for known population structures through minor allele frequencies. In the simulated gene-level association studies under unbalanced settings, our method recovered up to 85% power loss caused by the standard methods. We further showed the power gain of our methods in gene-level tests with 26 unbalanced studies of age-related macular degeneration . In addition, we took the meta-analysis of three unbalanced studies of type 2 diabetes as an example to discuss the challenges of meta-analyzing multi-ethnic samples. In summary, our improved meta-score-statistics with corrections for population stratification can be used to construct both single-variant and gene-level association studies, providing a useful framework for ensuring well-powered, convenient, cross-study analyses. © 2018 WILEY PERIODICALS, INC.

Prenatal diagnosis of a fetus with unbalanced translocation (4;13)(p16;q32) with overlapping features of Patau and Wolf-Hirschhorn syndromes.

PubMed

Tapper, Jill K; Zhang, Shuliu; Harirah, Hassan M; Panova, Neli I; Merryman, Linda S; Hawkins, Judy C; Lockhart, Lillian H; Gei, Alfredo B; Velagaleti, Gopalrao V N

2002-01-01

Wolf-Hirschhorn syndrome (WHS) and Patau syndrome are two of the most severe conditions resulting from chromosome abnormalities. WHS is caused by a deletion of 4p16, while Patau syndrome is caused by trisomy for some or all regions of chromosome 13. Though the etiologies of these syndromes differ, they share several features including pre- and postnatal growth retardation, microcephaly, cleft lip and palate, and cardiac anomalies. We present here a female fetus with deletion of 4p16 --> pter and duplication of 13q32 --> qter due to unbalanced segregation of t(4;13)(p16;q32) in the father. She displayed overlapping features of both of these syndromes on ultrasound. To the best of our knowledge, this is the first report of a fetus with both partial trisomy 13 and deletion of 4p16, the critical region for WHS. Copyright 2002 S. Karger AG, Basel

High speed ultra-broadband amplitude modulators with ultrahigh extinction >65 dB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, S.; Cai, H.; DeRose, C. T.

Here, we experimentally demonstrate ultrahigh extinction ratio (>65 dB) amplitude modulators (AMs) that can be electrically tuned to operate across a broad spectral range of 160 nm from 1480 – 1640 nm and 95 nm from 1280 – 1375 nm. Our on-chip AMs employ one extra coupler compared with conventional Mach-Zehnder interferometers (MZI), thus form a cascaded MZI (CMZI) structure. Either directional or adiabatic couplers are used to compose the CMZI AMs and experimental comparisons are made between these two different structures. Furthermore, we investigate the performance of CMZI AMs under extreme conditions such as using 95:5 split ratio couplersmore » and unbalanced waveguide losses. Electro-optic phase shifters are also integrated in the CMZI AMs for high-speed operation. Finally, we investigate the output optical phase when the amplitude is modulated, which provides us valuable information when both amplitude and phase are to be controlled. This demonstration not only paves the road to applications such as quantum information processing that requires high extinction ratio AMs but also significantly alleviates the tight fabrication tolerance needed for large-scale integrated photonics.« less

High speed ultra-broadband amplitude modulators with ultrahigh extinction >65 dB

DOE PAGES

Liu, S.; Cai, H.; DeRose, C. T.; ...

2017-05-04

Here, we experimentally demonstrate ultrahigh extinction ratio (>65 dB) amplitude modulators (AMs) that can be electrically tuned to operate across a broad spectral range of 160 nm from 1480 – 1640 nm and 95 nm from 1280 – 1375 nm. Our on-chip AMs employ one extra coupler compared with conventional Mach-Zehnder interferometers (MZI), thus form a cascaded MZI (CMZI) structure. Either directional or adiabatic couplers are used to compose the CMZI AMs and experimental comparisons are made between these two different structures. Furthermore, we investigate the performance of CMZI AMs under extreme conditions such as using 95:5 split ratio couplersmore » and unbalanced waveguide losses. Electro-optic phase shifters are also integrated in the CMZI AMs for high-speed operation. Finally, we investigate the output optical phase when the amplitude is modulated, which provides us valuable information when both amplitude and phase are to be controlled. This demonstration not only paves the road to applications such as quantum information processing that requires high extinction ratio AMs but also significantly alleviates the tight fabrication tolerance needed for large-scale integrated photonics.« less

Design of limited-stop service based on the degree of unbalance of passenger demand

PubMed Central

2018-01-01

This paper presents a limited-stop service for a bus fleet to meet the unbalanced demand of passengers on a bus route and to improve the transit service of the bus route. This strategy includes two parts: a degree assessment of unbalanced passenger demand and an optimization of the limited-stop service. The degree assessment of unbalanced passenger demand, which is based on the different passenger demand between stations and the unbalance of passengers within the station, is used to judge whether implementing the limited-stop service is necessary for a bus route. The optimization of limited-stop service considers the influence of stop skipping action and bus capacity on the left-over passengers to determine the proper skipping stations for the bus fleet serving the entire route by minimizing both the waiting time and in-vehicle time of passengers and the running time of vehicles. A solution algorithm based on genetic algorithm is also presented to evaluate the degree of unbalanced passenger demand and optimize the limited-stop scheme. Then, the proper strategy is tested on a bus route in Changchun city of China. The threshold of degree assessment of unbalanced passenger demand can be calibrated and adapted to different passenger demands. PMID:29505585

Design of limited-stop service based on the degree of unbalance of passenger demand.

PubMed

Zhang, Hu; Zhao, Shuzhi; Liu, Huasheng; Liang, Shidong

2018-01-01

This paper presents a limited-stop service for a bus fleet to meet the unbalanced demand of passengers on a bus route and to improve the transit service of the bus route. This strategy includes two parts: a degree assessment of unbalanced passenger demand and an optimization of the limited-stop service. The degree assessment of unbalanced passenger demand, which is based on the different passenger demand between stations and the unbalance of passengers within the station, is used to judge whether implementing the limited-stop service is necessary for a bus route. The optimization of limited-stop service considers the influence of stop skipping action and bus capacity on the left-over passengers to determine the proper skipping stations for the bus fleet serving the entire route by minimizing both the waiting time and in-vehicle time of passengers and the running time of vehicles. A solution algorithm based on genetic algorithm is also presented to evaluate the degree of unbalanced passenger demand and optimize the limited-stop scheme. Then, the proper strategy is tested on a bus route in Changchun city of China. The threshold of degree assessment of unbalanced passenger demand can be calibrated and adapted to different passenger demands.

Use of a Microprocessor to Implement an ADCCP Protocol (Federal Std-1003) Operating in the Unbalanced Normal Mode.

DTIC Science & Technology

1980-05-01

andcoptrpormigfrteublne nra ls fpoeue nacrac with Federal Standard 1003 fTelecommunications: Synchronous Bit Oriented Data Link Control Procedures...and the higher level user. The solution to the producer/consumer problem involves the use of PASS and SICHAL primitives and event variables or... semaphores . The event variables have been defined for the LS-microprocessor interface as part of I-1 the internal registers that are included in the F6856

Implementation of a Balance Operator in NCOM

DTIC Science & Technology

2016-04-07

the background temperature Tb and salinity Sb fields do), f is the Coriolis parameter, k is the vertical unit vector, ∇ is the horizontal gradient, p... effectively used as a natural metric in the space of cost function gradients. The associated geometry inhibits descent in the unbalanced directions and...28) where f is the local Coriolis parameter, ∆yv is the local grid spacing in the y direction at a v point, and the overbars indicates horizontal

Coordinated Optimization of Distributed Energy Resources and Smart Loads in Distribution Systems: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Rui; Zhang, Yingchen

2016-08-01

Distributed energy resources (DERs) and smart loads have the potential to provide flexibility to the distribution system operation. A coordinated optimization approach is proposed in this paper to actively manage DERs and smart loads in distribution systems to achieve the optimal operation status. A three-phase unbalanced Optimal Power Flow (OPF) problem is developed to determine the output from DERs and smart loads with respect to the system operator's control objective. This paper focuses on coordinating PV systems and smart loads to improve the overall voltage profile in distribution systems. Simulations have been carried out in a 12-bus distribution feeder andmore » results illustrate the superior control performance of the proposed approach.« less

Coordinated Optimization of Distributed Energy Resources and Smart Loads in Distribution Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Rui; Zhang, Yingchen

2016-11-14

Distributed energy resources (DERs) and smart loads have the potential to provide flexibility to the distribution system operation. A coordinated optimization approach is proposed in this paper to actively manage DERs and smart loads in distribution systems to achieve the optimal operation status. A three-phase unbalanced Optimal Power Flow (OPF) problem is developed to determine the output from DERs and smart loads with respect to the system operator's control objective. This paper focuses on coordinating PV systems and smart loads to improve the overall voltage profile in distribution systems. Simulations have been carried out in a 12-bus distribution feeder andmore » results illustrate the superior control performance of the proposed approach.« less

Echocardiographic definition and surgical decision-making in unbalanced atrioventricular septal defect: a Congenital Heart Surgeons' Society multiinstitutional study.

PubMed

Jegatheeswaran, Anusha; Pizarro, Christian; Caldarone, Christopher A; Cohen, Meryl S; Baffa, Jeanne M; Gremmels, David B; Mertens, Luc; Morell, Victor O; Williams, William G; Blackstone, Eugene H; McCrindle, Brian W; Overman, David M

2010-09-14

Although identification of unbalanced atrioventricular septal defect (AVSD) is obvious when extreme, exact criteria to define the limits of unbalanced are not available. We sought to validate an atrioventricular valve index (AVVI) (left atrioventricular valve area/total atrioventricular valve area, centimeters squared) as a discriminator of balanced and unbalanced forms of complete AVSD and to characterize the association of AVVI with surgical strategies and outcomes. Diagnostic echocardiograms and hospital records of 356 infants with complete AVSD at 4 Congenital Heart Surgeons' Society (CHSS) institutions (2000-2006) were reviewed and AVVI measured (n=315). Patients were classified as unbalanced if AVVI≤0.4 (right dominant) or ≥0.6 (left dominant). Surgical strategy and outcomes were examined across the range of AVVI. Competing risks analysis until the time of commitment to a surgical strategy examined 4 end states: biventricular repair (BVR), univentricular repair (UVR), pulmonary artery banding (PAB), and death before surgery. A prediction nomogram for surgical strategy based on AVVI was developed. The majority of patients had balanced AVSD (0.4

Anomalous Transient Amplification of Waves in Non-normal Photonic Media

NASA Astrophysics Data System (ADS)

Makris, K. G.; Ge, L.; Türeci, H. E.

2014-10-01

Dissipation is a ubiquitous phenomenon in dynamical systems encountered in nature because no finite system is fully isolated from its environment. In optical systems, a key challenge facing any technological application has traditionally been the mitigation of optical losses. Recent work has shown that a new class of optical materials that consist of a precisely balanced distribution of loss and gain can be exploited to engineer novel functionalities for propagating and filtering electromagnetic radiation. Here we show a generic property of optical systems that feature an unbalanced distribution of loss and gain, described by non-normal operators, namely, that an overall lossy optical system can transiently amplify certain input signals by several orders of magnitude. We present a mathematical framework to analyze the dynamics of wave propagation in media with an arbitrary distribution of loss and gain, and we construct the initial conditions to engineer such non-normal power amplifiers. Our results point to a new design space for engineered optical systems employed in photonics and quantum optics.

Hall-Effect Based Semi-Fast AC On-Board Charging Equipment for Electric Vehicles

PubMed Central

Milanés-Montero, María Isabel; Gallardo-Lozano, Javier; Romero-Cadaval, Enrique; González-Romera, Eva

2011-01-01

The expected increase in the penetration of electric vehicles (EV) and plug-in hybrid electric vehicles (PHEV) will produce unbalanced conditions, reactive power consumption and current harmonics drawn by the battery charging equipment, causing a great impact on the power quality of the future smart grid. A single-phase semi-fast electric vehicle battery charger is proposed in this paper. This ac on-board charging equipment can operate in grid-to-vehicle (G2V) mode, and also in vehicle-to-grid (V2G) mode, transferring the battery energy to the grid when the vehicle is parked. The charger is controlled with a Perfect Harmonic Cancellation (PHC) strategy, contributing to improve the grid power quality, since the current demanded or injected has no harmonic content and a high power factor. Hall-effect current and voltage transducers have been used in the sensor stage to carry out this control strategy. Experimental results with a laboratory prototype are presented. PMID:22163697

Hall-effect based semi-fast AC on-board charging equipment for electric vehicles.

PubMed

Milanés-Montero, María Isabel; Gallardo-Lozano, Javier; Romero-Cadaval, Enrique; González-Romera, Eva

2011-01-01

The expected increase in the penetration of electric vehicles (EV) and plug-in hybrid electric vehicles (PHEV) will produce unbalanced conditions, reactive power consumption and current harmonics drawn by the battery charging equipment, causing a great impact on the power quality of the future smart grid. A single-phase semi-fast electric vehicle battery charger is proposed in this paper. This ac on-board charging equipment can operate in grid-to-vehicle (G2V) mode, and also in vehicle-to-grid (V2G) mode, transferring the battery energy to the grid when the vehicle is parked. The charger is controlled with a Perfect Harmonic Cancellation (PHC) strategy, contributing to improve the grid power quality, since the current demanded or injected has no harmonic content and a high power factor. Hall-effect current and voltage transducers have been used in the sensor stage to carry out this control strategy. Experimental results with a laboratory prototype are presented.

Microbial characteristics in anaerobic digestion process of food waste for methane production-A review.

PubMed

Wang, Pan; Wang, Hongtao; Qiu, Yinquan; Ren, Lianhai; Jiang, Bin

2018-01-01

Food waste (FW) is rich in starch, fat, protein and cellulose. It is easy to decay and brings environmental pollution and other social problems. FW shows a high potential to produce methane by anaerobic digestion (AD) due to its high organic content. However, many inhibitors, such as accumulation of ammonia and volatile fatty acids (VFAs), usually result in inefficient performances and even process failure. Microorganisms play an important role in the process of hydrolysis, acidogenesis, acetogenesis and methanogenesis. This review provided a critical summary of microbial characteristics to obtain connects of microbial community structure with operational conditions at various states of AD, such as mesophilic and thermophilic, wet and dry, success and failure, pretreated or not, lab-scale and full-scale. This article emphasizes that it is necessary to analyze changes and mechanisms of microbial communities in unbalanced system and seek efficiency dynamic succession rules of the dominant microorganisms. Copyright © 2017. Published by Elsevier Ltd.

Three-phase Four-leg Inverter LabVIEW FPGA Control Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

In the area of power electronics control, Field Programmable Gate Arrays (FPGAs) have the capability to outperform their Digital Signal Processor (DSP) counterparts due to the FPGA’s ability to implement true parallel processing and therefore facilitate higher switching frequencies, higher control bandwidth, and/or enhanced functionality. National Instruments (NI) has developed two platforms, Compact RIO (cRIO) and Single Board RIO (sbRIO), which combine a real-time processor with an FPGA. The FPGA can be programmed with a subset of the well-known LabVIEW graphical programming language. The use of cRIO and sbRIO for power electronics control has developed over the last few yearsmore » to include control of three-phase inverters. Most three-phase inverter topologies include three switching legs. The addition of a fourth-leg to natively generate the neutral connection allows the inverter to serve single-phase loads in a microgrid or stand-alone power system and to balance the three-phase voltages in the presence of significant load imbalance. However, the control of a four-leg inverter is much more complex. In particular, instead of standard two-dimensional space vector modulation (SVM), the inverter requires three-dimensional space vector modulation (3D-SVM). The candidate software implements complete control algorithms in LabVIEW FPGA for a three-phase four-leg inverter. The software includes feedback control loops, three-dimensional space vector modulation gate-drive algorithms, advanced alarm handling capabilities, contactor control, power measurements, and debugging and tuning tools. The feedback control loops allow inverter operation in AC voltage control, AC current control, or DC bus voltage control modes based on external mode selection by a user or supervisory controller. The software includes the ability to synchronize its AC output to the grid or other voltage-source before connection. The software also includes provisions to allow inverter operation in parallel with other voltage regulating devices on the AC or DC buses. This flexibility allows the Inverter to operate as a stand-alone voltage source, connected to the grid, or in parallel with other controllable voltage sources as part of a microgrid or remote power system. In addition, as the inverter is expected to operate under severe unbalanced conditions, the software includes algorithms to accurately compute real and reactive power for each phase based on definitions provided in the IEEE Standard 1459: IEEE Standard Definitions for the Measurement of Electric Power Quantities Under Sinusoidal, Nonsinusoidal, Balanced, or Unbalanced Conditions. Finally, the software includes code to output analog signals for debugging and for tuning of control loops. The software fits on the Xilinx Virtex V LX110 FPGA embedded in the NI cRIO-9118 FPGA chassis, and with a 40 MHz base clock, supports a modulation update rate of 40 MHz, user-settable switching frequencies and synchronized control loop update rates of tens of kHz, and reference waveform generation, including Phase Lock Loop (PLL), update rate of 100 kHz.« less

Nonlinear rotordynamics analysis. [Space Shuttle Main Engine turbopumps

NASA Technical Reports Server (NTRS)

Noah, Sherif T.

1991-01-01

Effective analysis tools were developed for predicting the nonlinear rotordynamic behavior of the Space Shuttle Main Engine (SSME) turbopumps under steady and transient operating conditions. Using these methods, preliminary parametric studies were conducted on both generic and actual HPOTP (high pressure oxygen turbopump) models. In particular, a novel modified harmonic balance/alternating Fourier transform (HB/AFT) method was developed and used to conduct a preliminary study of the effects of fluid, bearing and seal forces on the unbalanced response of a multi-disk rotor in the presence of bearing clearances. The method makes it possible to determine periodic, sub-, super-synchronous and chaotic responses of a rotor system. The method also yields information about the stability of the obtained response, thus allowing bifurcation analyses. This provides a more effective capability for predicting the response under transient conditions by searching in proximity of resonance peaks. Preliminary results were also obtained for the nonlinear transient response of an actual HPOTP model using an efficient, newly developed numerical method based on convolution integration. Currently, the HB/AFT is being extended for determining the aperiodic response of nonlinear systems. Initial results show the method to be promising.

The potential of oxygen to improve the stability of anaerobic reactors during unbalanced conditions: results from a pilot-scale digester treating sewage sludge.

PubMed

Ramos, I; Fdz-Polanco, M

2013-07-01

A well-functioning pilot reactor treating sewage sludge at approximately 4.4 NL/m(3)/d of oxygen supply and 18d of hydraulic retention time (HRT) was subjected to a hydraulic overload to investigate whether oxygen benefits successful operation in stressful circumstances. Only a mild imbalance was caused, which was overcome without deterioration in the digestion performance. Volatile solids (VS) removal was 45% and 43% at 18 and 14 d of HRT, respectively. Biogas productivity remained around 546 NmL/gVS, but it was slightly higher during the period of imbalance. Thereafter, similar performances were achieved. Under anaerobic conditions, VS removal and biogas productivity were respectively 41% and 525 NmL/gVS, hydrogen partial pressure rose, and acetic acid formation became less favourable. Oxygen seemed to form a more stable digestion system, which meant increased ability to deal successfully with overloads. Additionally, it improved the biogas quality; methane concentration was negligibly lower, while hydrogen sulphide and oxygen remained around 0.02 and 0.03%v/v, respectively. Copyright © 2013 Elsevier Ltd. All rights reserved.

Planar diode multiplier chains for THz spectroscopy

NASA Technical Reports Server (NTRS)

Maiwald, Frank W.; Drouin, Brian J.; Pearson, John C.; Mehdi, Imran; Lewena, Frank; Endres, Christian; Winnewisser, Gisbert

2005-01-01

High-resolution laboratory spectroscopy is utilized as a diagnostic tool to determine noise and harmonic content of balanced [9]-[11] and unbalanced [12]-[14] multiplier designs. Balanced multiplier designs suppress unintended harmonics more than -20dB. Much smaller values were measured on unbalanced multipliers.

Primary TKA Patients with Quantifiably Balanced Soft-Tissue Achieve Significant Clinical Gains Sooner than Unbalanced Patients

PubMed Central

Gustke, Kenneth A.; Golladay, Gregory J.; Roche, Martin W.; Elson, Leah C.; Anderson, Christopher R.

2014-01-01

Although total knee arthroplasty has a high success rate, poor outcomes and early revision are associated with ligament imbalance. This multicenter evaluation was performed in order to provide 1-year followup of a previously reported group of patients who had sensor-assisted TKA, comparing the clinical outcomes of quantitatively balanced versus unbalanced patients. At 1 year, the balanced cohort scored 179.3 and 10.4 in KSS and WOMAC, respectively; the unbalanced cohort scored 156.1 and 17.9 in KSS and WOMAC (P < 0.001; P = 0.085). The average activity level scores of quantitatively balanced patients were 68.6 (corresponding to tennis, light jogging, and heavy yard work), while the average activity level of unbalanced patients was 46.7 (corresponding to light housework, and limited walking distances) (P = 0.015). Out of all confounding variables, a balanced articulation was the most significant contributing factor to improved postoperative outcomes (P < 0.001). PMID:25210632

High Fidelity, “Faster than Real-Time” Simulator for Predicting Power System Dynamic Behavior - Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flueck, Alex

The “High Fidelity, Faster than Real­Time Simulator for Predicting Power System Dynamic Behavior” was designed and developed by Illinois Institute of Technology with critical contributions from Electrocon International, Argonne National Laboratory, Alstom Grid and McCoy Energy. Also essential to the project were our two utility partners: Commonwealth Edison and AltaLink. The project was a success due to several major breakthroughs in the area of large­scale power system dynamics simulation, including (1) a validated faster than real­ time simulation of both stable and unstable transient dynamics in a large­scale positive sequence transmission grid model, (2) a three­phase unbalanced simulation platform formore » modeling new grid devices, such as independently controlled single­phase static var compensators (SVCs), (3) the world’s first high fidelity three­phase unbalanced dynamics and protection simulator based on Electrocon’s CAPE program, and (4) a first­of­its­ kind implementation of a single­phase induction motor model with stall capability. The simulator results will aid power grid operators in their true time of need, when there is a significant risk of cascading outages. The simulator will accelerate performance and enhance accuracy of dynamics simulations, enabling operators to maintain reliability and steer clear of blackouts. In the long­term, the simulator will form the backbone of the newly conceived hybrid real­time protection and control architecture that will coordinate local controls, wide­area measurements, wide­area controls and advanced real­time prediction capabilities. The nation’s citizens will benefit in several ways, including (1) less down time from power outages due to the faster­than­real­time simulator’s predictive capability, (2) higher levels of reliability due to the detailed dynamics plus protection simulation capability, and (3) more resiliency due to the three­ phase unbalanced simulator’s ability to model three­phase and single­ phase networks and devices.« less

Frequency noise suppression of a single mode laser with an unbalanced fiber interferometer for subnanometer interferometry.

PubMed

Šmíd, Radek; Čížek, Martin; Mikel, Břetislav; Číp, Ondřej

2015-01-12

We present a method of noise suppression of laser diodes by an unbalanced Michelson fiber interferometer. The unstabilized laser source is represented by compact planar waveguide external cavity laser module, ORIONTM (Redfern Integrated Optics, Inc.), working at 1540.57 nm with a 1.5-kHz linewidth. We built up the unbalanced Michelson interferometer with a 2.09 km-long arm based on the standard telecommunication single-mode fiber (SMF-28) spool to suppress the frequency noise by the servo-loop control by 20 dB to 40 dB within the Fourier frequency range, remaining the tuning range of the laser frequency.

Performance Evaluation of Distributed Systems with Unbalanced Flows: An Analysis of the INFOPLEX Data Storage Hierarchy.

DTIC Science & Technology

1984-07-01

34. - . . ’-... " " " ". ’ UNCLASSIFIED SECURITY CLASSIFICATION OF T0IS PAGE (lhen Det £ntered) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS...RUMERODF PAGES 267 14 MONITORING AGENCY NAME & ADDRESS(II dillerent from Controllind Office) IS. SECURITY CLASS. (o this report) UNCLASSIFIED ISa...lower storage level. This is the basis for the mapping of the PIL3 read operation and workloads into a queueing netowrk model. S PAGE 135 REFERENCE

Frequency Noise Suppression of a Single Mode Laser with an Unbalanced Fiber Interferometer for Subnanometer Interferometry

PubMed Central

Šmíd, Radek; Čížek, Martin; Mikel, Břetislav; Číp, Ondřej

2015-01-01

We present a method of noise suppression of laser diodes by an unbalanced Michelson fiber interferometer. The unstabilized laser source is represented by compact planar waveguide external cavity laser module, ORIONTM (Redfern Integrated Optics, Inc.), working at 1540.57 nm with a 1.5-kHz linewidth. We built up the unbalanced Michelson interferometer with a 2.09 km-long arm based on the standard telecommunication single-mode fiber (SMF-28) spool to suppress the frequency noise by the servo-loop control by 20 dB to 40 dB within the Fourier frequency range, remaining the tuning range of the laser frequency. PMID:25587980

A novel passive micromixer based on unbalanced splits and collisions of fluid streams

NASA Astrophysics Data System (ADS)

Ansari, Mubashshir Ahmad; Kim, Kwang-Yong; Anwar, Khalid; Kim, Sun Min

2010-05-01

A new passive micromixer based on the concept of unbalanced splits and cross-collisions of fluid streams is designed and fabricated. Experimental and numerical studies have been carried out on the micromixer at Reynolds numbers ranging from 10 to 80. The three-dimensional Navier-Stokes equations have been used to analyze the mixing and flow behavior of the micromixer, which is composed of two sub-channels of unequal widths which repeatedly undergo splitting and recombination. The difference between the mass flow rates in the two sub-channels creates an unbalanced collision of the two fluid streams. Mixing is mainly due to the combined effect of unbalanced collisions of the fluid streams and Dean vortices. The micromixer shows interesting mixing behavior for different ratios of the widths of the two split sub-channels. The sub-channels wherein the major sub-channel is twice as wide as the minor sub-channel exhibit the highest mixing performance at Reynolds numbers larger than 40. The results show the lowest mixing performance for the case of uniform width, where balanced collisions occur.

GOES dynamic propagation of attitude

NASA Astrophysics Data System (ADS)

Markley, F. Landis; Seidewitz, Ed; Chu, Don; Rowe, John N.

1988-09-01

The spacecraft in the next series of Geostationary Operational Environmental Satellites (GOES-Next) are Earth pointing and have 5-year mission lifetimes. Because gyros can be depended on only for a few years of continuous use, they will be turned off during routine operations. This means attitude must, at times, be determined without benefit of gyros and, often, using only Earth sensor data. To minimize the interruption caused by dumping angular momentum, these spacecraft have been designed to reduce the environmental torque acting on them and incorporate an adjustable solar trim tab for fine adjustment. A new support requirement for GOES-Next is that of setting the solar trim tab. Optimizing its setting requires an estimate of the unbalanced torque on the spacecraft. These two requirements, determining attitude without gyros and estimating the external torque, are addressed by replacing or supplementing the gyro propagation with a dynamic one, that is, one that integrates the rigid body equations of motion. By processing quarter-orbit or longer batches, this approach takes advantage of roll-yaw coupling to observe attitude completely without Sun sensor data. Telemetered momentum wheel speeds are used as observations of the unbalanced external torques. GOES-Next provides a unique opportunity to study dynamic attitude propagation. The geosynchronous altitude and adjustable trim tab minimize the external torque and its uncertainty, making long-term dynamic propagation feasible. This paper presents the equations for dynamic propagation, an analysis of the environmental torques, and an estimate of the accuracies obtainable with the proposed method.

Practical quantum private query of blocks based on unbalanced-state Bennett-Brassard-1984 quantum-key-distribution protocol

NASA Astrophysics Data System (ADS)

Wei, Chun-Yan; Gao, Fei; Wen, Qiao-Yan; Wang, Tian-Yin

2014-12-01

Until now, the only kind of practical quantum private query (QPQ), quantum-key-distribution (QKD)-based QPQ, focuses on the retrieval of a single bit. In fact, meaningful message is generally composed of multiple adjacent bits (i.e., a multi-bit block). To obtain a message from database, the user Alice has to query l times to get each ai. In this condition, the server Bob could gain Alice's privacy once he obtains the address she queried in any of the l queries, since each ai contributes to the message Alice retrieves. Apparently, the longer the retrieved message is, the worse the user privacy becomes. To solve this problem, via an unbalanced-state technique and based on a variant of multi-level BB84 protocol, we present a protocol for QPQ of blocks, which allows the user to retrieve a multi-bit block from database in one query. Our protocol is somewhat like the high-dimension version of the first QKD-based QPQ protocol proposed by Jacobi et al., but some nontrivial modifications are necessary.

VALORATE: fast and accurate log-rank test in balanced and unbalanced comparisons of survival curves and cancer genomics.

PubMed

Treviño, Victor; Tamez-Pena, Jose

2017-06-15

The association of genomic alterations to outcomes in cancer is affected by a problem of unbalanced groups generated by the low frequency of alterations. For this, an R package (VALORATE) that estimates the null distribution and the P -value of the log-rank based on a recent reformulation is presented. For a given number of alterations that define the size of survival groups, the log-rank density is estimated by a weighted sum of conditional distributions depending on a co-occurrence term of mutations and events. The estimations are accurately accelerated by sampling across co-occurrences allowing the analysis of large genomic datasets in few minutes. In conclusion, the proposed VALORATE R package is a valuable tool for survival analysis. The R package is available in CRAN at https://cran.r-project.org and in http://bioinformatica.mty.itesm.mx/valorateR . vtrevino@itesm.mx. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Convergence analysis of directed signed networks via an M-matrix approach

NASA Astrophysics Data System (ADS)

Meng, Deyuan

2018-04-01

This paper aims at solving convergence problems on directed signed networks with multiple nodes, where interactions among nodes are described by signed digraphs. The convergence analysis is achieved by matrix-theoretic and graph-theoretic tools, in which M-matrices play a central role. The fundamental digon sign-symmetry assumption upon signed digraphs can be removed with the proposed analysis approach. Furthermore, necessary and sufficient conditions are established for semi-positive and positive stabilities of Laplacian matrices of signed digraphs, respectively. A benefit of this result is that given strong connectivity, a directed signed network can achieve bipartite consensus (or state stability) if and only if the signed digraph associated with it is structurally balanced (or unbalanced). If the interactions between nodes are described by a signed digraph only with spanning trees, a directed signed network can achieve interval bipartite consensus (or state stability) if and only if the signed digraph contains a structurally balanced (or unbalanced) rooted subgraph. Simulations are given to illustrate the developed results by considering signed networks associated with digon sign-unsymmetric signed digraphs.

Practical quantum private query of blocks based on unbalanced-state Bennett-Brassard-1984 quantum-key-distribution protocol

PubMed Central

Wei, Chun-Yan; Gao, Fei; Wen, Qiao-Yan; Wang, Tian-Yin

2014-01-01

Until now, the only kind of practical quantum private query (QPQ), quantum-key-distribution (QKD)-based QPQ, focuses on the retrieval of a single bit. In fact, meaningful message is generally composed of multiple adjacent bits (i.e., a multi-bit block). To obtain a message from database, the user Alice has to query l times to get each ai. In this condition, the server Bob could gain Alice's privacy once he obtains the address she queried in any of the l queries, since each ai contributes to the message Alice retrieves. Apparently, the longer the retrieved message is, the worse the user privacy becomes. To solve this problem, via an unbalanced-state technique and based on a variant of multi-level BB84 protocol, we present a protocol for QPQ of blocks, which allows the user to retrieve a multi-bit block from database in one query. Our protocol is somewhat like the high-dimension version of the first QKD-based QPQ protocol proposed by Jacobi et al., but some nontrivial modifications are necessary. PMID:25518810

Studies on the psychosomatic functioning of ill-health according to eastern and Western medicine. 2. Anxiety-affinitive constitution associated with qi, blood, and body fluid--diagnostic and therapeutic methods.

PubMed

Takeichi, M; Sato, T; Takefu, M

1999-01-01

The objective of this investigation was to identify characteristics of psychosomatic function in medical students (N = 62, mean age, 23.3, SD, 1.7 years) whose ill-health was related to unbalanced qi, blood, and body fluid, and to develop a diagnosis and treatment method for these conditions. Our study revealed complicated characteristics. At the psychological level, these characteristics are stress-related emotional disturbances, including anxiety, insomnia and anergy, and the lowering of social function. At the physiological level, these characteristics are associated with high complexity of fractal dimension of eye (horizontal) and respiratory (thoracic) movements correlated to STA1-trait anxiety. Thus, the three psychosomatic characteristics related to unbalanced qi, blood, and body fluid suggest the concept of an anxiety-affinitive constitution, also described as the equivalent of ill-health. This indicates that diagnosis and treatment of this type of constitution has the potential to be useful for both the prevention of stress-related and life-style disease, and the treatment of current disease.

Trend of sex ratio at birth in a public hospital in Hong Kong from 2001 to 2010.

PubMed

Tse, W C; Leung, K Y; Hung, Beatrice K M

2013-08-01

To identify factors affecting the sex ratio at birth. Cross-sectional study. Obstetric department of a public hospital in Hong Kong. All pregnant women delivered between 2001 and 2010. Sex ratio at birth versus women's eligibility status, age, parity, number of miscarriages or terminations of pregnancy, and number of fetuses were analysed using the Chi squared test. Multivariate regression was used to determine the effects of multiple factors on the sex of the newborn. A total of 54 039 cases were reviewed. The sex ratio at birth changed since 2003, and became unbalanced (>107 males per 100 females) since 2006 revealed by a significant increase in males per 100 females, from 106.6 in 2001-2005 to 111.4 in 2006-2010. From 2001 to 2010, the sex ratio at birth increased from being balanced to becoming unbalanced in eligible persons, and became more unbalanced in non-eligible persons. The ratio increased in eligible persons after having two children, but in non-eligible persons after having one child. The sex ratio at birth was unbalanced (1.095) in singleton pregnancies, but balanced (1.019) in multiple pregnancies. Based on logistic regression, the chance of a male baby being born increased with parity of 2 or above (odds ratio=1.1; P<0.001), non-eligible person status (odds ratio=1.05; P=0.034), and delivery in the period 2006-2010 (odds ratio=1.04; P=0.019). The ratio was not increased with advanced maternal age, the number of miscarriages/terminations of pregnancy, and number of fetuses. Compared with 2001-2005, the sex ratio at birth became unbalanced in 2006-2010. An unbalanced ratio ensued in the latter period in both eligible and non-eligible persons, but to a greater extent and even after having one child in the latter group.

Overcoming the knowledge-behavior gap: The effect of evidence-based HPV vaccination leaflets on understanding, intention, and actual vaccination decision.

PubMed

Wegwarth, O; Kurzenhäuser-Carstens, S; Gigerenzer, G

2014-03-10

Informed decision making requires transparent and evidence-based (=balanced) information on the potential benefit and harms of medical preventions. An analysis of German HPV vaccination leaflets revealed, however, that none met the standards of balanced risk communication. We surveyed a sample of 225 girl-parent pairs in a before-after design on the effects of balanced and unbalanced risk communication on participants' knowledge about cervical cancer and the HPV vaccination, their perceived risk, their intention to have the vaccine, and their actual vaccination decision. The balanced leaflet increased the number of participants who were correctly informed about cervical cancer and the HPV vaccine by 33 to 66 absolute percentage points. In contrast, the unbalanced leaflet decreased the number of participants who were correctly informed about these facts by 0 to 18 absolute percentage points. Whereas the actual uptake of the HPV vaccination 14 months after the initial study did not differ between the two groups (22% balanced leaflet vs. 23% unbalanced leaflet; p=.93, r=.01), the originally stated intention to have the vaccine reliably predicted the actual vaccination decision for the balanced leaflet group only (concordance between intention and actual uptake: 97% in the balanced leaflet group, rs=.92, p=.00; 60% in the unbalanced leaflet group, rs=.37, p=.08). In contrast to a unbalanced leaflet, a balanced leaflet increased people's knowledge of the HPV vaccination, improved perceived risk judgments, and led to an actual vaccination uptake, which first was robustly predicted by people's intention and second did not differ from the uptake in the unbalanced leaflet group. These findings suggest that balanced reporting about HPV vaccination increases informed decisions about whether to be vaccinated and does not undermine actual uptake. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Controllable Grid Interface for Testing Ancillary Service Controls and Fault Performance of Utility-Scale Wind Power Generation: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gevorgian, Vahan; Koralewicz, Przemyslaw; Wallen, Robb

The rapid expansion of wind power has led many transmission system operators to demand modern wind power plants to comply with strict interconnection requirements. Such requirements involve various aspects of wind power plant operation, including fault ride-through and power quality performance as well as the provision of ancillary services to enhance grid reliability. During recent years, the National Renewable Energy Laboratory (NREL) of the U.S. Department of Energy has developed a new, groundbreaking testing apparatus and methodology to test and demonstrate many existing and future advanced controls for wind generation (and other renewable generation technologies) on the multimegawatt scale andmore » medium-voltage levels. This paper describes the capabilities and control features of NREL's 7-MVA power electronic grid simulator (also called a controllable grid interface, or CGI) that enables testing many active and reactive power control features of modern wind turbine generators -- including inertial response, primary and secondary frequency responses, and voltage regulation -- under a controlled, medium-voltage grid environment. In particular, this paper focuses on the specifics of testing the balanced and unbalanced fault ride-through characteristics of wind turbine generators under simulated strong and weak medium-voltage grid conditions. In addition, this paper provides insights on the power hardware-in-the-loop feature implemented in the CGI to emulate (in real time) the conditions that might exist in various types of electric power systems under normal operations and/or contingency scenarios. Using actual test examples and simulation results, this paper describes the value of CGI as an ultimate modeling validation tool for all types of 'grid-friendly' controls by wind generation.« less

TUBE TESTER

DOEpatents

Gittings, H.T. Jr.; Kalbach, J.F.

1958-01-14

This patent relates to tube testing, and in particular describes a tube tester for automatic testing of a number of vacuum tubes while in service and as frequently as may be desired. In it broadest aspects the tube tester compares a particular tube with a standard tube tarough a difference amplifier. An unbalanced condition in the circuit of the latter produced by excessive deviation of the tube in its characteristics from standard actuates a switch mechanism stopping the testing cycle and indicating the defective tube.

Is there a genuine advantage to the upper part of words during lexical access? Evidence from the Stroop task.

PubMed

Tejero, Pilar; Perea, Manuel; Jiménez, María

2014-07-01

A number of recent visual-word recognition and reading experiments have concluded that the upper part of words is more important for lexical access than is the lower part, which conforms with Huey's (1908) observation. Here, we examined whether this phenomenon may simply be due to the fact that words in Indo-European languages tend to have a higher number of confusable letters in the lower than in the upper part. We manipulated the letter ambiguity of the upper and lower parts of words in two experiments in which we asked participants to report the presentation color of the upper and lower parts of color words and noncolor words, and in a baseline condition, of strings of &s (Stroop task). In Experiment 1, the lower part of noncolor words was more ambiguous than the upper part (upward-unbalanced words), whereas in Experiment 2, the ambiguities of the two parts of the noncolor words were similar (balanced words). For the upward-unbalanced noncolor words, the magnitude of lexical interference (relative to the baseline condition) was greater for the upper than for the lower part. Critically, the differences vanished when this factor was controlled (i.e., balanced words; Exp. 2). Thus, the apparent bias in favor of the upper part of words can be parsimoniously described as an idiosyncratic feature of the words' component letters.

Deposition and characterization of TiAlSiN nanocomposite coatings prepared by reactive pulsed direct current unbalanced magnetron sputtering

NASA Astrophysics Data System (ADS)

Barshilia, Harish C.; Ghosh, Moumita; Shashidhara; Ramakrishna, Raja; Rajam, K. S.

2010-08-01

This work reports the performance of high speed steel drill bits coated with TiAlSiN nanocomposite coating at different Si contents (5.5-8.1 at.%) prepared using a four-cathode reactive pulsed direct current unbalanced magnetron sputtering system. The surface morphology of the as-deposited coatings was characterized using field emission scanning electron microscopy. The crystallographic structure, chemical composition and bonding structure were evaluated using X-ray diffraction, energy-dispersive X-ray analysis, X-ray photoelectron spectroscopy, respectively. The corrosion behavior, mechanical properties and thermal stability of TiAlSiN nanocomposite coatings were also studied using potentiodynamic polarization, nanoindentation and Raman spectroscopy, respectively. The TiAlSiN coating thickness was approximately 2.5-2.9 μm. These coatings exhibited a maximum hardness of 38 GPa at a silicon content of approximately 6.9 at.% and were stable in air up to 850 °C. For the performance evaluation, the TiAlSiN coated drills were tested under accelerated machining conditions by drilling a 12 mm thick 304 stainless steel plate. Under dry conditions the uncoated drill bits failed after drilling 50 holes, whereas, TiAlSiN coated drill bits (Si = 5.5 at.%) drilled 714 holes before failure. Results indicated that for TiAlSiN coated drill bits the tool life increased by a factor of more than 14.

Xurography as a Rapid Fabrication Alternative for Point-of-Care Devices: Assessment of Passive Micromixers

PubMed Central

Martínez-López, J. Israel; Mojica, Mauricio; Rodríguez, Ciro A.; Siller, Héctor R.

2016-01-01

Despite the copious amount of research on the design and operation of micromixers, there are few works regarding manufacture technology aimed at implementation beyond academic environments. This work evaluates the viability of xurography as a rapid fabrication tool for the development of ultra-low cost microfluidic technology for extreme Point-of-Care (POC) micromixing devices. By eschewing photolithographic processes and the bulkiness of pumping and enclosure systems for rapid fabrication and passively driven operation, xurography is introduced as a manufacturing alternative for asymmetric split and recombine (ASAR) micromixers. A T-micromixer design was used as a reference to assess the effects of different cutting conditions and materials on the geometric features of the resulting microdevices. Inspection by stereographic and confocal microscopy showed that it is possible to manufacture devices with less than 8% absolute dimensional error. Implementation of the manufacturing methodology in modified circular shape- based SAR microdevices (balanced and unbalanced configurations) showed that, despite the precision limitations of the xurographic process, it is possible to implement this methodology to produce functional micromixing devices. Mixing efficiency was evaluated numerically and experimentally at the outlet of the microdevices with performances up to 40%. Overall, the assessment encourages further research of xurography for the development of POC micromixers. PMID:27196904

Xurography as a Rapid Fabrication Alternative for Point-of-Care Devices: Assessment of Passive Micromixers.

PubMed

Martínez-López, J Israel; Mojica, Mauricio; Rodríguez, Ciro A; Siller, Héctor R

2016-05-16

Despite the copious amount of research on the design and operation of micromixers, there are few works regarding manufacture technology aimed at implementation beyond academic environments. This work evaluates the viability of xurography as a rapid fabrication tool for the development of ultra-low cost microfluidic technology for extreme Point-of-Care (POC) micromixing devices. By eschewing photolithographic processes and the bulkiness of pumping and enclosure systems for rapid fabrication and passively driven operation, xurography is introduced as a manufacturing alternative for asymmetric split and recombine (ASAR) micromixers. A T-micromixer design was used as a reference to assess the effects of different cutting conditions and materials on the geometric features of the resulting microdevices. Inspection by stereographic and confocal microscopy showed that it is possible to manufacture devices with less than 8% absolute dimensional error. Implementation of the manufacturing methodology in modified circular shape- based SAR microdevices (balanced and unbalanced configurations) showed that, despite the precision limitations of the xurographic process, it is possible to implement this methodology to produce functional micromixing devices. Mixing efficiency was evaluated numerically and experimentally at the outlet of the microdevices with performances up to 40%. Overall, the assessment encourages further research of xurography for the development of POC micromixers.

Is This Object Balanced or Unbalanced? Judgments Are on the Safe Side

ERIC Educational Resources Information Center

Samuel, Francoise; Kerzel, Dirk

2011-01-01

Do we perceive correctly whether a 2-D object is balanced or unbalanced? What would be the cause of biased equilibrium judgments? In two psychometric studies, we varied independently the characteristics of the objects and the equilibrium states. First, we observed that observers were excessively sensitive to the eccentricity of the object top.…

Visualization in Mechanics: The Dynamics of an Unbalanced Roller

ERIC Educational Resources Information Center

Cumber, Peter S.

2017-01-01

It is well known that mechanical engineering students often find mechanics a difficult area to grasp. This article describes a system of equations describing the motion of a balanced and an unbalanced roller constrained by a pivot arm. A wide range of dynamics can be simulated with the model. The equations of motion are embedded in a graphical…

Investigation of the impact of main control room digitalization on operators cognitive reliability in nuclear power plants.

PubMed

Zhou, Yong; Mu, Haiying; Jiang, Jianjun; Zhang, Li

2012-01-01

Currently, there is a trend in nuclear power plants (NPPs) toward introducing digital and computer technologies into main control rooms (MCRs). Safe generation of electric power in NPPs requires reliable performance of cognitive tasks such as fault detection, diagnosis, and response planning. The digitalization of MCRs has dramatically changed the whole operating environment, and the ways operators interact with the plant systems. If the design and implementation of the digital technology is incompatible with operators' cognitive characteristics, it may have negative effects on operators' cognitive reliability. Firstly, on the basis of three essential prerequisites for successful cognitive tasks, a causal model is constructed to reveal the typical human performance issues arising from digitalization. The cognitive mechanisms which they impact cognitive reliability are analyzed in detail. Then, Bayesian inference is used to quantify and prioritize the influences of these factors. It suggests that interface management and unbalanced workload distribution have more significant impacts on operators' cognitive reliability.

Behavioural and physiological effects of finely balanced decision-making in chickens.

PubMed

Davies, Anna C; Nicol, Christine J; Persson, Mia E; Radford, Andrew N

2014-01-01

In humans, more difficult decisions result in behavioural and physiological changes suggestive of increased arousal, but little is known about the effect of decision difficulty in other species. A difficult decision can have a number of characteristics; we aimed to monitor how finely balanced decisions, compared to unbalanced ones, affected the behaviour and physiology of chickens. An unbalanced decision was one in which the two options were of unequal net value (1 (Q1) vs. 6 (Q6) pieces of sweetcorn with no cost associated with either option); a finely balanced decision was one in which the options were of equal net value (i.e. hens were "indifferent" to both options). To identify hens' indifference, a titration procedure was used in which a cost (electromagnetic weight on an access door) was applied to the Q6 option, to find the individual point at which hens chose this option approximately equally to Q1 via a non-weighted door. We then compared behavioural and physiological indicators of arousal (head movements, latency to choose, heart-rate variability and surface body temperature) when chickens made decisions that were unbalanced or finely balanced. Significant physiological (heart-rate variability) and behavioural (latency to pen) differences were found between the finely balanced and balanced conditions, but these were likely to be artefacts of the greater time and effort required to push through the weighted doors. No other behavioural and physiological measures were significantly different between the decision categories. We suggest that more information is needed on when best to monitor likely changes in arousal during decision-making and that future studies should consider decisions defined as difficult in other ways.

Fatigue Lifespan of Engine Box Influenced by Fan Blade Out

NASA Astrophysics Data System (ADS)

Qiu, Ju; Shi, Jingwei; Su, Huaizhong; Zhang, Jinling; Feng, Juan; Shi, Qian; Tian, Xiaoyu

2017-11-01

This provides precious experience and reliable reference data for future design. This paper introduces the analysis process of Fan-blade-out, and considers the effect of windmill load on the fatigue lifespan of the case. According to Extended Operations (ETOPS) in the airworthiness regulations, the fatigue crack of it is analyzed by the unbalanced rotor load, during FBO. Compared with the lifespan in normal work of the engine, this research provides valuable design experience and reliable reference data for the case design in the near future.

Wavelength-division and spatial multiplexing using tandem interferometers for Bragg grating sensor networks

NASA Astrophysics Data System (ADS)

Kalli, K.; Brady, G. P.; Webb, D. J.; Jackson, D. A.; Zhang, L.; Bennion, I.

1995-12-01

We present a new method for the interrogation of large arrays of Bragg grating sensors. Eight gratings operating between the wavelengths of 1533 and 1555 nm have been demultiplexed. An unbalanced Mach-Zehnder interferometer illuminated by a single low-coherence source provides a high-phase-resolution output for each sensor, the outputs of which are sequentially selected in wavelength by a tunable Fabry-Perot interferometer. The minimum detectable strain measured was 90 n 3 / \\radical Hz \\end-radical at 7 Hz for a wavelength of 1535 nm.

Experimental evidence for homeostatic sex allocation after sex-biased reintroductions.

PubMed

Linklater, Wayne Leslie; Law, Peter Roy; Gedir, Jay Vinson; du Preez, Pierre

2017-03-06

First principles predict negative frequency-dependent sex allocation, but it is unproven in field studies and seldom considered, despite far-reaching consequences for theory and practice in population genetics and dynamics as well as animal ecology and behaviour. Twenty-four years of rhinoceros calving after 45 reintroductions across southern Africa provide the first in situ experimental evidence that unbalanced operational sex ratios predicted offspring sex and offspring sex ratios. Our understanding of population dynamics, especially reintroduction and invasion biology, will be significantly impacted by these findings.

Two Words, One Meaning: Evidence of Automatic Co-Activation of Translation Equivalents

PubMed Central

Dimitropoulou, Maria; Duñabeitia, Jon Andoni; Carreiras, Manuel

2011-01-01

Research on the processing of translations offers important insights on how bilinguals negotiate the representation of words from two languages in one mind and one brain. Evidence so far has shown that translation equivalents effectively activate each other as well as their shared concept even when translations lack of any formal overlap (i.e., non-cognates) and even when one of them is presented subliminally, namely under masked priming conditions. In the lexical decision studies testing masked translation priming effects with unbalanced bilinguals a remarkably stable pattern emerges: larger effects in the dominant (L1) to the non-dominant (L2) translation direction, than vice versa. Interestingly, this asymmetry vanishes when simultaneous and balanced bilinguals are tested, suggesting that the linguistic profile of the bilinguals could be determining the pattern of cross-language lexico-semantic activation across the L2 learning trajectory. The present study aims to detect whether L2 proficiency is the critical variable rendering the otherwise asymmetric cross-language activation of translations obtained in the lexical decision task into symmetric. Non-cognate masked translation priming effects were examined with three groups of Greek (L1)–English (L2) unbalanced bilinguals, differing exclusively at their level of L2 proficiency. Although increased L2 proficiency led to improved overall L2 performance, masked translation priming effects were virtually identical across the three groups, yielding in all cases significant but asymmetric effects (i.e., larger effects in the L1 → L2 than in the L2 → L1 translation direction). These findings show that proficiency does not modulate masked translation priming effects at intermediate levels, and that a native-like level of L2 proficiency is needed for symmetric effects to emerge. They furthermore, pose important constraints on the operation of the mechanisms underlying the development of cross-language lexico-semantic links. PMID:21886634

Newton's Law: Not so Simple after All

ERIC Educational Resources Information Center

Robertson, William C.; Gallagher, Jeremiah; Miller, William

2004-01-01

One of the most basic concepts related to force and motion is Newton's first law, which essentially states, "An object at rest tends to remain at rest unless acted on by an unbalanced force. An object in motion in a straight line tends to remain in motion in a straight line unless acted upon by an unbalanced force." Judging by the time and space…

Thermal analysis of cylindrical natural-gas steam reformer for 5 kW PEMFC

NASA Astrophysics Data System (ADS)

Jo, Taehyun; Han, Junhee; Koo, Bonchan; Lee, Dohyung

2016-11-01

The thermal characteristics of a natural-gas based cylindrical steam reformer coupled with a combustor are investigated for the use with a 5 kW polymer electrolyte membrane fuel cell. A reactor unit equipped with nickel-based catalysts was designed to activate the steam reforming reaction without the inclusion of high-temperature shift and low-temperature shift processes. Reactor temperature distribution and its overall thermal efficiency depend on various inlet conditions such as the equivalence ratio, the steam to carbon ratio (SCR), and the fuel distribution ratio (FDR) into the reactor and the combustor components. These experiments attempted to analyze the reformer's thermal and chemical properties through quantitative evaluation of product composition and heat exchange between the combustor and the reactor. FDR is critical factor in determining the overall performance as unbalanced fuel injection into the reactor and the combustor deteriorates overall thermal efficiency. Local temperature distribution also influences greatly on the fuel conversion rate and thermal efficiency. For the experiments, the operation conditions were set as SCR was in range of 2.5-4.0 and FDR was in 0.4-0.7 along with equivalence ratio of 0.9-1.1; optimum results were observed for FDR of 0.63 and SCR of 3.0 in the cylindrical steam reformer.

Paralleling power MOSFETs in their active region: Extended range of passively forced current sharing

NASA Technical Reports Server (NTRS)

Niedra, Janis M.

1989-01-01

A simple passive circuit that improves current balance in parallelled power MOSFETs that are not precisely matched and that are operated in their active region from a common gate drive are exhibited. A nonlinear circuit consisting of diodes and resistors generates the differential gate potential required to correct for unbalance while maintaining low losses over a range of current. Also application of a thin tape wound magnetic core to effect dynamic current balance is reviewed, and a simple theory is presented showing that for operation in the active region the branch currents tend to revert to their normal unbalanced values even if the core is not driven into saturation. Results of several comparative experiments are given.

SOCIAL PSYCHOLOGICAL CONSIDERATIONS OF RACIALLY-BALANCED SCHOOLS, PRESENTED AT NEW YORK STATE EDUCATION DEPARTMENT CONFERENCE, GREYSTONE CONFERENCE CENTER MARCH 31, 1964, NEW YORK CITY.

ERIC Educational Resources Information Center

PAJONAS, PATRICIA; PETTIGREW, THOMAS F.

RACIALLY-UNBALANCED SCHOOLS SHOULD BE VIEWED WITH INTENSE CONCERN. NEGRO AMERICANS HAVE LEARNED THAT RACIALLY BALANCED FACILITIES ARE NECESSARY IF THEY ARE TO RECEIVE ANYTHING RESEMBLING EQUAL OPPORTUNITY. BALANCED SCHOOLS ARE NEEDED TO INSURE THE NECESSARY POLITICAL LEVERAGE. LEGALLY, THE QUESTION OF UNBALANCED SCHOOLS WAS ANSWERED IN THE 1954…

Abnormal chromosome complement resulting from a familial inversion of chromosome 2.

PubMed Central

Richter, S; Lockwood, B; Lockwood, D; Allanson, J

1989-01-01

It has been suggested that pericentric inversions of chromosome 2 increase the risk for spontaneous abortion but do not increase the risk for unbalanced recombinant offspring. We report our experience of a familial pericentric inversion of chromosome 2 resulting in two unbalanced recombinant offspring. Both subjects have 46,XX,rec(2),dup q,inv(2)(p25q35). Images PMID:2479747

Unbalanced Nature, Unbounded Bodies, and Unlimited Technology: Ecocriticism and Karen Traviss' Wess'har Series

ERIC Educational Resources Information Center

Sullivan, Heather I.

2010-01-01

While nature is often claimed to be a space of harmonized balance or an antidote to the chaos of the modern world, we need a more grounded assessment of nature as endlessly changing and much less predictable than we like to assume. In this essay, I explore Karen Traviss' provocative exploration of unbalanced nature and unbounded bodies in her…

Effect of Space Vehicle Structure Vibration on Control Moment Gyroscope Dynamics

NASA Technical Reports Server (NTRS)

Dobrinskaya, Tatiana

2008-01-01

Control Moment Gyroscopes (CMGs) are used for non-propulsive attitude control of satellites and space stations, including the International Space Station (ISS). CMGs could be essential for future long duration space missions due to the fact that they help to save propellant. CMGs were successfully tested on the ground for many years, and have been successfully used on satellites. However, operations have shown that the CMG service life on the ISS is significantly shorter than predicted. Since the dynamic environment of the ISS differs greatly from the nominal environment of satellites, it was important to analyze how operations specific to the station (dockings and undockings, huge solar array motion, crew exercising, robotic operations, etc) can affect the CMG performance. This task became even more important since the first CMG failure onboard the ISS. The CMG failure resulted in the limitation of the attitude control capabilities, more propellant consumption, and additional operational issues. Therefore, the goal of this work was to find out how the vibrations of a space vehicle structure, caused by a variety of onboard operations, can affect the CMG dynamics and performance. The equations of CMG motion were derived and analyzed for the case when the gyro foundation can vibrate in any direction. The analysis was performed for unbalanced CMG gimbals to match the CMG configuration on ISS. The analysis showed that vehicle structure vibrations can amplify and significantly change the CMG motion if the gyro gimbals are unbalanced in flight. The resonance frequencies were found. It was shown that the resonance effect depends on the magnitude of gimbal imbalance, on the direction of a structure vibration, and on gimbal bearing friction. Computer modeling results of CMG dynamics affected by the external vibration are presented. The results can explain some of the CMG vibration telemetry observed on ISS. This work shows that balancing the CMG gimbals decreases the effect of vehicle structure vibration on CMGs. Additionally, the effect of external vibrations may also be decreased by increasing the gimbal bearing friction. With the suggested modifications there may be no need to lower the gimbal rates below the nominal design requirements as it is currently done on ISS. The conclusions of this work

The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients.

PubMed

Boldt, Joachim; Suttner, Stephan; Brosch, Christian; Lehmann, Andreas; Röhm, Kerstin; Mengistu, Andinet

2009-03-01

A balanced fluid replacement strategy appears to be promising for correcting hypovolemia. The benefits of a balanced fluid replacement regimen were studied in elderly cardiac surgery patients. In a randomized clinical trial, 50 patients aged >75 years undergoing cardiac surgery received a balanced 6% HES 130/0.42 plus a balanced crystalloid solution (n = 25) or a non-balanced HES in saline plus saline solution (n = 25) to keep pulmonary capillary wedge pressure/central venous pressure between 12-14 mmHg. Acid-base status, inflammation, endothelial activation (soluble intercellular adhesion molecule-1, kidney integrity (kidney-specific proteins glutathione transferase-alpha; neutrophil gelatinase-associated lipocalin) were studied after induction of anesthesia, 5 h after surgery, 1 and 2 days thereafter. Serum creatinine (sCr) was measured approximately 60 days after discharge. A total of 2,750 +/- 640 mL of balanced and 2,820 +/- 550 mL of unbalanced HES were given until the second POD. Base excess (BE) was significantly reduced in the unbalanced (from +1.21 +/- 0.3 to -4.39 +/- 1.0 mmol L(-1) 5 h after surgery; P < 0.001) and remained unchanged in the balanced group (from 1.04 +/- 0.3 to -0.81 +/- 0.3 mmol L(-1) 5 h after surgery). Evolution of the BE was significantly different. Inflammatory response and endothelial activation were significantly less pronounced in the balanced than the unbalanced group. Concentrations of kidney-specific proteins after surgery indicated less alterations of kidney integrity in the balanced than in the unbalanced group. A total balanced volume replacement strategy including a balanced HES and a balanced crystalloid solution resulted in moderate beneficial effects on acid-base status, inflammation, endothelial activation, and kidney integrity compared to a conventional unbalanced volume replacement regimen.

Recurrence, submicroscopic complexity, and potential clinical relevance of copy gains detected by array CGH that are shown to be unbalanced insertions by FISH.

PubMed

Neill, Nicholas J; Ballif, Blake C; Lamb, Allen N; Parikh, Sumit; Ravnan, J Britt; Schultz, Roger A; Torchia, Beth S; Rosenfeld, Jill A; Shaffer, Lisa G

2011-04-01

Insertions occur when a segment of one chromosome is translocated and inserted into a new region of the same chromosome or a non-homologous chromosome. We report 71 cases with unbalanced insertions identified using array CGH and FISH in 4909 cases referred to our laboratory for array CGH and found to have copy-number abnormalities. Although the majority of insertions were non-recurrent, several recurrent unbalanced insertions were detected, including three der(Y)ins(Y;18)(q?11.2;p11.32p11.32)pat inherited from parents carrying an unbalanced insertion. The clinical significance of these recurrent rearrangements is unclear, although the small size, limited gene content, and inheritance pattern of each suggests that the phenotypic consequences may be benign. Cryptic, submicroscopic duplications were observed at or near the insertion sites in two patients, further confounding the clinical interpretation of these insertions. Using FISH, linear amplification, and array CGH, we identified a 126-kb duplicated region from 19p13.3 inserted into MECP2 at Xq28 in a patient with symptoms of Rett syndrome. Our results demonstrate that although the interpretation of most non-recurrent insertions is unclear without high-resolution insertion site characterization, the potential for an otherwise benign duplication to result in a clinically relevant outcome through the disruption of a gene necessitates the use of FISH to determine whether copy-number gains detected by array CGH represent tandem duplications or unbalanced insertions. Further follow-up testing using techniques such as linear amplification or sequencing should be used to determine gene involvement at the insertion site after FISH has identified the presence of an insertion.

Processing of Signals from Fiber Bragg Gratings Using Unbalanced Interferometers

NASA Technical Reports Server (NTRS)

Adamovsky, Grigory; Juergens, Jeff; Floyd, Bertram

2005-01-01

Fiber Bragg gratings (FBG) have become preferred sensory structures in fiber optic sensing system. High sensitivity, embedability, and multiplexing capabilities make FBGs superior to other sensor configurations. The main feature of FBGs is that they respond in the wavelength domain with the wavelength of the returned signal as the indicator of the measured parameter. The wavelength is then converted to optical intensity by a photodetector to detect corresponding changes in intensity. This wavelength-to-intensity conversion is a crucial part in any FBG-based sensing system. Among the various types of wavelength-to-intensity converters, unbalanced interferometers are especially attractive because of their small weight and volume, lack of moving parts, easy integration, and good stability. In this paper we investigate the applicability of unbalanced interferometers to analyze signals reflected from Bragg gratings. Analytical and experimental data are presented.

The Roles of Relative Linguistic Proficiency and Modality Switching in Language Switch Cost: Evidence from Chinese Visual Unimodal and Bimodal Bilinguals.

PubMed

Lu, Aitao; Wang, Lu; Guo, Yuyang; Zeng, Jiahong; Zheng, Dongping; Wang, Xiaolu; Shao, Yulan; Wang, Ruiming

2017-09-01

The current study investigated the mechanism of language switching in unbalanced visual unimodal bilinguals as well as balanced and unbalanced bimodal bilinguals during a picture naming task. All three groups exhibited significant switch costs across two languages, with symmetrical switch cost in balanced bimodal bilinguals and asymmetrical switch cost in unbalanced unimodal bilinguals and bimodal bilinguals. Moreover, the relative proficiency of the two languages but not their absolute proficiency had an effect on language switch cost. For the bimodal bilinguals the language switch cost also arose from modality switching. These findings suggest that the language switch cost might originate from multiple sources from both outside (e.g., modality switching) and inside (e.g., the relative proficiency of the two languages) the linguistic lexicon.

What drives health care expenditure?--Baumol's model of 'unbalanced growth' revisited.

PubMed

Hartwig, Jochen

2008-05-01

The share of health care expenditure in GDP rises rapidly in virtually all OECD countries, causing increasing concern among politicians and the general public. Yet, economists have to date failed to reach an agreement on what the main determinants of this development are. This paper revisits Baumol's [Baumol, W.J., 1967. Macroeconomics of unbalanced growth: the anatomy of urban crisis. American Economic Review 57 (3), 415-426] model of 'unbalanced growth', showing that the latter offers a ready explanation for the observed inexorable rise in health care expenditure. The main implication of Baumol's model in this context is that health care expenditure is driven by wage increases in excess of productivity growth. This hypothesis is tested empirically using data from a panel of 19 OECD countries. Our tests yield robust evidence in favor of Baumol's theory.

Practical quantum private query of blocks based on unbalanced-state Bennett-Brassard-1984 quantum-key-distribution protocol.

PubMed

Wei, Chun-Yan; Gao, Fei; Wen, Qiao-Yan; Wang, Tian-Yin

2014-12-18

Until now, the only kind of practical quantum private query (QPQ), quantum-key-distribution (QKD)-based QPQ, focuses on the retrieval of a single bit. In fact, meaningful message is generally composed of multiple adjacent bits (i.e., a multi-bit block). To obtain a message a1a2···al from database, the user Alice has to query l times to get each ai. In this condition, the server Bob could gain Alice's privacy once he obtains the address she queried in any of the l queries, since each a(i) contributes to the message Alice retrieves. Apparently, the longer the retrieved message is, the worse the user privacy becomes. To solve this problem, via an unbalanced-state technique and based on a variant of multi-level BB84 protocol, we present a protocol for QPQ of blocks, which allows the user to retrieve a multi-bit block from database in one query. Our protocol is somewhat like the high-dimension version of the first QKD-based QPQ protocol proposed by Jacobi et al., but some nontrivial modifications are necessary.

Ensemble Pruning for Glaucoma Detection in an Unbalanced Data Set.

PubMed

Adler, Werner; Gefeller, Olaf; Gul, Asma; Horn, Folkert K; Khan, Zardad; Lausen, Berthold

2016-12-07

Random forests are successful classifier ensemble methods consisting of typically 100 to 1000 classification trees. Ensemble pruning techniques reduce the computational cost, especially the memory demand, of random forests by reducing the number of trees without relevant loss of performance or even with increased performance of the sub-ensemble. The application to the problem of an early detection of glaucoma, a severe eye disease with low prevalence, based on topographical measurements of the eye background faces specific challenges. We examine the performance of ensemble pruning strategies for glaucoma detection in an unbalanced data situation. The data set consists of 102 topographical features of the eye background of 254 healthy controls and 55 glaucoma patients. We compare the area under the receiver operating characteristic curve (AUC), and the Brier score on the total data set, in the majority class, and in the minority class of pruned random forest ensembles obtained with strategies based on the prediction accuracy of greedily grown sub-ensembles, the uncertainty weighted accuracy, and the similarity between single trees. To validate the findings and to examine the influence of the prevalence of glaucoma in the data set, we additionally perform a simulation study with lower prevalences of glaucoma. In glaucoma classification all three pruning strategies lead to improved AUC and smaller Brier scores on the total data set with sub-ensembles as small as 30 to 80 trees compared to the classification results obtained with the full ensemble consisting of 1000 trees. In the simulation study, we were able to show that the prevalence of glaucoma is a critical factor and lower prevalence decreases the performance of our pruning strategies. The memory demand for glaucoma classification in an unbalanced data situation based on random forests could effectively be reduced by the application of pruning strategies without loss of performance in a population with increased risk of glaucoma.

[On the rational distribution of Chinese population].

PubMed

Zhu, Z

1980-01-01

In 1949, the population distribution in China was characterized by the following distinct features. First, it was unbalanced, with high density in the eastern regions, in the plains, and in areas adjacent to railroads, river navigation routes and other transportation axes. Low population density was found in the western regions, mountainous regions, and areas far from transportation routes. Second, Hans were largest in number and distributed throughout the country, with major concentration in the eastern regions, while the minorities constituted about 10% of the total population and were distributed mainly in the far southwestern and northwestern areas. Third, over 89% of the 540 million of the population was distributed in rural areas while only about 10% in towns and cities, with high densities in some coastal cities. During the past 3 decades, the unbalanced nature of China's population has remained basically unchanged. This can be attributed to factors relating to natural conditions and resources, productivities, socioeconomic conditions, and technological development in different regions. In order to achieve a rational distribution of the Chinese population the following measures should be taken: 1) controlling the birth rate of the Hans and increasing the population of minorities; 2) moving the population of the dense areas to the border provinces in the western regions to develop their natural resources and to elevate the living standards; 3) modernizing the rural areas; 4) strictly controlling the industrial developments of large cities and their population growth; and 5) strictly restricting the unplanned migration of population to and from cities.

Persistence border collisions in a vibrating system excited by an unbalanced motor with a relay control

NASA Astrophysics Data System (ADS)

Zhusubaliyev, Zhanybai T.; Avrutin, Viktor; Rubanov, Vasily G.; Bushuev, Dmitry A.; Titov, Dmitry V.; Yanochkina, Olga O.

2018-05-01

The paper describes a new scenario for the transition to complex dynamics in a vibrating system with an unbalanced rotor and a relay feedback control. We show that the transition from a regular dynamics without switching events in the relay element to an irregular dynamics which takes place completely in the hysteresis region occurs via a cascade of persistence border collisions.

Evaporation rate of nucleating clusters.

PubMed

Zapadinsky, Evgeni

2011-11-21

The Becker-Döring kinetic scheme is the most frequently used approach to vapor liquid nucleation. In the present study it has been extended so that master equations for all cluster configurations are included into consideration. In the Becker-Döring kinetic scheme the nucleation rate is calculated through comparison of the balanced steady state and unbalanced steady state solutions of the set of kinetic equations. It is usually assumed that the balanced steady state produces equilibrium cluster distribution, and the evaporation rates are identical in the balanced and unbalanced steady state cases. In the present study we have shown that the evaporation rates are not identical in the equilibrium and unbalanced steady state cases. The evaporation rate depends on the number of clusters at the limit of the cluster definition. We have shown that the ratio of the number of n-clusters at the limit of the cluster definition to the total number of n-clusters is different in equilibrium and unbalanced steady state cases. This causes difference in evaporation rates for these cases and results in a correction factor to the nucleation rate. According to rough estimation it is 10(-1) by the order of magnitude and can be lower if carrier gas effectively equilibrates the clusters. The developed approach allows one to refine the correction factor with Monte Carlo and molecular dynamic simulations.

Modeling track access charge to enhance railway industry performance

NASA Astrophysics Data System (ADS)

Berawi, Mohammed Ali; Miraj, Perdana; Berawi, Abdur Rohim Boy; Susantono, Bambang; Leviakangas, Pekka; Radiansyah, Hendra

2017-11-01

Indonesia attempts to improve nation's competitiveness by increasing the quality and the availability of railway network. However, the infrastructure improperly managed by the operator in terms of the technical issue. One of the reasons for this problem is an unbalanced value of infrastructure charge. In 2000's track access charge and infrastructure maintenance and operation for Indonesia railways are equal and despite current formula of the infrastructure charge, issues of transparency and accountability still in question. This research aims to produce an alternative scheme of track access charge by considering marginal cost plus markup (MC+) approach. The research combines qualitative and quantitative method through an in-depth interview and financial analysis. The result will generate alternative formula of infrastructure charge in Indonesia's railway industry. The simulation also conducted to estimate track access charge for the operator and to forecast government support in terms of subsidy. The result is expected to enhance railway industry performance and competitiveness.

Intelligent switches of integrated lightwave circuits with core telecommunication functions

NASA Astrophysics Data System (ADS)

Izhaky, Nahum; Duer, Reuven; Berns, Neil; Tal, Eran; Vinikman, Shirly; Schoenwald, Jeffrey S.; Shani, Yosi

2001-05-01

We present a brief overview of a promising switching technology based on Silica on Silicon thermo-optic integrated circuits. This is basically a 2D solid-state optical device capable of non-blocking switching operation. Except of its excellent performance (insertion loss<5dB, switching time<2ms...), the switch enables additional important build-in functionalities. It enables single-to- single channel switching and single-to-multiple channel multicasting/broadcasting. In addition, it has the capability of channel weighting and variable output power control (attenuation), for instance, to equalize signal levels and compensate for unbalanced different optical input powers, or to equalize unbalanced EDFA gain curve. We examine the market segments appropriate for the switch size and technology, followed by a discussion of the basic features of the technology. The discussion is focused on important requirements from the switch and the technology (e.g., insertion loss, power consumption, channel isolation, extinction ratio, switching time, and heat dissipation). The mechanical design is also considered. It must take into account integration of optical fiber, optical planar wafer, analog electronics and digital microprocessor controls, embedded software, and heating power dissipation. The Lynx Photon.8x8 switch is compared to competing technologies, in terms of typical market performance requirements.

Autovibration and chaotic motion of an unbalanced rotor in massive non-linear compliant supports

NASA Astrophysics Data System (ADS)

Pasynkova, I. A.; Stepanova, P. P.

2018-05-01

Stability loss scenarios of an unbalanced rotor with a flexible massless shaft mounted in massive non-linear compliant supports are studied on the example of cylindrical precession. Dyffing type of non-linearity in compliant supports is considered. The system "rotor - supports" has eight degrees of freedom. Internal and external friction are taken into account. Autovibrations and chaotic vibrations are obtained. The results are confirmed by numerical check.

The use of analysis of variance procedures in biological studies

USGS Publications Warehouse

Williams, B.K.

1987-01-01

The analysis of variance (ANOVA) is widely used in biological studies, yet there remains considerable confusion among researchers about the interpretation of hypotheses being tested. Ambiguities arise when statistical designs are unbalanced, and in particular when not all combinations of design factors are represented in the data. This paper clarifies the relationship among hypothesis testing, statistical modelling and computing procedures in ANOVA for unbalanced data. A simple two-factor fixed effects design is used to illustrate three common parametrizations for ANOVA models, and some associations among these parametrizations are developed. Biologically meaningful hypotheses for main effects and interactions are given in terms of each parametrization, and procedures for testing the hypotheses are described. The standard statistical computing procedures in ANOVA are given along with their corresponding hypotheses. Throughout the development unbalanced designs are assumed and attention is given to problems that arise with missing cells.

Visual gate for brain-computer interfaces.

PubMed

Dias, N S; Jacinto, L R; Mendes, P M; Correia, J H

2009-01-01

Brain-Computer Interfaces (BCI) based on event related potentials (ERP) have been successfully developed for applications like virtual spellers and navigation systems. This study tests the use of visual stimuli unbalanced in the subject's field of view to simultaneously cue mental imagery tasks (left vs. right hand movement) and detect subject attention. The responses to unbalanced cues were compared with the responses to balanced cues in terms of classification accuracy. Subject specific ERP spatial filters were calculated for optimal group separation. The unbalanced cues appear to enhance early ERPs related to cue visuospatial processing that improved the classification accuracy (as low as 6%) of ERPs in response to left vs. right cues soon (150-200 ms) after the cue presentation. This work suggests that such visual interface may be of interest in BCI applications as a gate mechanism for attention estimation and validation of control decisions.

Effect of control surface mass unbalance on the stability of a closed-loop active control system

NASA Technical Reports Server (NTRS)

Nissim, E.

1989-01-01

The effects on stability of inertial forces arising from closed-loop activation of mass-unbalanced control surfaces are studied analytically using inertial energy approach, similar to the aerodynamic energy approach used for flutter suppression. The limitations of a single control surface like a leading-edge (LE) control or a trailing-edge (TE) control are demonstrated and compared to the superior combined LE-TE mass unbalanced system. It is shown that a spanwise section for sensor location can be determined which ensures minimum sensitivity to the mode shapes of the aircraft. It is shown that an LE control exhibits compatibility between inertial stabilization and aerodynamic stabilization, and that a TE control lacks such compatibility. The results of the present work should prove valuable, both for the purpose of flutter suppression using mass unbalanced control surfaces, or for the stabilization of structural modes of large space structures by means of inertial forces.

How Does Tropical Cyclone Size Affect the Onset Timing of Secondary Eyewall Formation?

NASA Astrophysics Data System (ADS)

Guan, Liang; Ge, Xuyang

2018-02-01

By using idealized numerical simulations, the impact of tropical cyclone size on secondary eyewall formation (SEF) is examined. Both unbalanced boundary layer and balanced processes are examined to reveal the underlying mechanism. The results show that a tropical cyclone (TC) with a larger initial size favors a quicker SEF and a larger outer eyewall. For a TC with a larger initial size, it will lead to a stronger surface entropy flux, and thus more active outer convection. Meanwhile, a greater inertial stability helps the conversion from diabatic heating to kinetic energy. Furthermore, the progressively broadening of the tangential wind field will induce significant boundary layer imbalances. This unbalanced boundary layer process results in a supergradient wind zone that acts as an important mechanism for triggering and maintaining deep convection. In short, different behaviors of balanced and unbalanced processes associated with the initial wind profile lead to different development rates of the secondary eyewall.

Evaluation of the Display of Cognitive State Feedback to Drive Adaptive Task Sharing

PubMed Central

Dorneich, Michael C.; Passinger, Břetislav; Hamblin, Christopher; Keinrath, Claudia; Vašek, Jiři; Whitlow, Stephen D.; Beekhuyzen, Martijn

2017-01-01

This paper presents an adaptive system intended to address workload imbalances between pilots in future flight decks. Team performance can be maximized when task demands are balanced within crew capabilities and resources. Good communication skills enable teams to adapt to changes in workload, and include the balancing of workload between team members This work addresses human factors priorities in the aviation domain with the goal to develop concepts that balance operator workload, support future operator roles and responsibilities, and support new task requirements, while allowing operators to focus on the most safety critical tasks. A traditional closed-loop adaptive system includes the decision logic to turn automated adaptations on and off. This work takes a novel approach of replacing the decision logic, normally performed by the automation, with human decisions. The Crew Workload Manager (CWLM) was developed to objectively display the workload between pilots and recommend task sharing; it is then the pilots who “close the loop” by deciding how to best mitigate unbalanced workload. The workload was manipulated by the Shared Aviation Task Battery (SAT-B), which was developed to provide opportunities for pilots to mitigate imbalances in workload between crew members. Participants were put in situations of high and low workload (i.e., workload was manipulated as opposed to being measured), the workload was then displayed to pilots, and pilots were allowed to decide how to mitigate the situation. An evaluation was performed that utilized the SAT-B to manipulate workload and create workload imbalances. Overall, the CWLM reduced the time spent in unbalanced workload and improved the crew coordination in task sharing while not negatively impacting concurrent task performance. Balancing workload has the potential to improve crew resource management and task performance over time, and reduce errors and fatigue. Paired with a real-time workload measurement system, the CWLM could help teams manage their own task load distribution. PMID:28400716

Evaluation of the Display of Cognitive State Feedback to Drive Adaptive Task Sharing.

PubMed

Dorneich, Michael C; Passinger, Břetislav; Hamblin, Christopher; Keinrath, Claudia; Vašek, Jiři; Whitlow, Stephen D; Beekhuyzen, Martijn

2017-01-01

This paper presents an adaptive system intended to address workload imbalances between pilots in future flight decks. Team performance can be maximized when task demands are balanced within crew capabilities and resources. Good communication skills enable teams to adapt to changes in workload, and include the balancing of workload between team members This work addresses human factors priorities in the aviation domain with the goal to develop concepts that balance operator workload, support future operator roles and responsibilities, and support new task requirements, while allowing operators to focus on the most safety critical tasks. A traditional closed-loop adaptive system includes the decision logic to turn automated adaptations on and off. This work takes a novel approach of replacing the decision logic, normally performed by the automation, with human decisions. The Crew Workload Manager (CWLM) was developed to objectively display the workload between pilots and recommend task sharing; it is then the pilots who "close the loop" by deciding how to best mitigate unbalanced workload. The workload was manipulated by the Shared Aviation Task Battery (SAT-B), which was developed to provide opportunities for pilots to mitigate imbalances in workload between crew members. Participants were put in situations of high and low workload (i.e., workload was manipulated as opposed to being measured), the workload was then displayed to pilots, and pilots were allowed to decide how to mitigate the situation. An evaluation was performed that utilized the SAT-B to manipulate workload and create workload imbalances. Overall, the CWLM reduced the time spent in unbalanced workload and improved the crew coordination in task sharing while not negatively impacting concurrent task performance. Balancing workload has the potential to improve crew resource management and task performance over time, and reduce errors and fatigue. Paired with a real-time workload measurement system, the CWLM could help teams manage their own task load distribution.

Scalable and reusable emulator for evaluating the performance of SS7 networks

NASA Astrophysics Data System (ADS)

Lazar, Aurel A.; Tseng, Kent H.; Lim, Koon Seng; Choe, Winston

1994-04-01

A scalable and reusable emulator was designed and implemented for studying the behavior of SS7 networks. The emulator design was largely based on public domain software. It was developed on top of an environment supported by PVM, the Parallel Virtual Machine, and managed by OSIMIS-the OSI Management Information Service platform. The emulator runs on top of a commercially available ATM LAN interconnecting engineering workstations. As a case study for evaluating the emulator, the behavior of the Singapore National SS7 Network under fault and unbalanced loading conditions was investigated.

Functional Dependence for Calculation of Additional Real-Power Losses in a Double-Wound Supply Transformer Caused by Unbalanced Active Inductive Load in a Star Connection with an Insulated Neutral

ERIC Educational Resources Information Center

Kostinskiy, Sergey S.; Troitskiy, Anatoly I.

2016-01-01

This article deals with the problem of calculating the additional real-power losses in double-wound supply transformers with voltage class 6 (10)/0,4 kV, caused by unbalanced active inductive load connected in a star connection with an insulated neutral. When solving the problem, authors used the theory of electric circuits, method of balanced…

The dentist's operating posture - ergonomic aspects.

PubMed

Pîrvu, C; Pătraşcu, I; Pîrvu, D; Ionescu, C

2014-06-15

The practice of dentistry involves laborious high finesse dental preparations, precision and control in executions that require a particular attention, concentration and patience of the dentist and finally the dentist's physical and mental resistance. The optimal therapeutic approach and the success of practice involve special working conditions for the dentist and his team in an ergonomic environment. The meaning of the posture in ergonomics is the manner in which different parts of the body are located and thus the reports are established between them in order to allow a special task execution. This article discusses the posture adopted by dentists when they work, beginning with the balanced posture and going to different variants of posture. The ideal posture of a dentist gives him, on the one hand the optimal working conditions (access, visibility and control in the mouth) and on the other hand, physical and psychological comfort throughout the execution of the clinical acts. Although the theme of dentist posture is treated with great care and often presented in the undergraduate courses and the continuing education courses on ergonomics in dentistry, many dentists do not know the subject well enough nor the theoretical issues and therefore nor the practical applicability. The risk and perspective of the musculoskeletal disorders related to unbalanced postures should determine the dentists take postural corrective actions and compensation measures in order to limit the negative effects of working in a bad posture.

The SCD - Stem Cell Differentiation ESA Project: Preparatory Work for the Spaceflight Mission

NASA Astrophysics Data System (ADS)

Versari, Silvia; Barenghi, Livia; van Loon, Jack; Bradamante, Silvia

2016-04-01

Due to spaceflight, astronauts experience serious, weightlessness-induced bone loss because of an unbalanced process of bone remodeling that involves bone marrow mesenchymal stem cells (BMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been extensively studied, but it is only recently that consideration has been given to the role of BMSCs. Previous researches indicated that human BMSCs cultured in simulated microgravity (sim-μg) alter their proliferation and differentiation. The spaceflight opportunities for biomedical experiments are rare and suffer from a number of operative constraints that could bias the validity of the experiment itself, but remain a unique opportunity to confirm and explain the effects due to microgravity, that are only partially activated/detectable in simulated conditions. For this reason, we carefully prepared the SCD - STEM CELLS DIFFERENTIATION experiment, selected by the European Space Agency (ESA) and now on the International Space Station (ISS). Here we present the preparatory studies performed on ground to adapt the project to the spaceflight constraints in terms of culture conditions, fixation and storage of human BMSCs in space aiming at satisfying the biological requirements mandatory to retrieve suitable samples for post-flight analyses. We expect to understand better the molecular mechanisms governing human BMSC growth and differentiation hoping to outline new countermeasures against astronaut bone loss.

Efficacy and safety of one-stage posterior hemivertebral resection for unbalanced multiple hemivertebrae: A more than 2-year follow-up.

PubMed

Huang, Yong; Feng, Ganjun; Song, Yueming; Liu, Limin; Zhou, Chunguang; Wang, Lei; Zhou, Zhongjie; Yang, Xi

2017-09-01

One-stage posterior hemivertebral resection has been proven to be an effective, reliable surgical option for treating congenital scoliosis due to a single hemivertebra. To date, however, no studies of treating unbalanced multiple hemivertebrae have appeared. This study evaluated the efficacy and safety of one-stage posterior hemivertebral resection for unbalanced multiple hemivertebrae. Altogether, we studied 15 patients with unbalanced multiple hemivertebrae who had undergone hemivertebral resection using the one-stage posterior approach with at least 2 years of follow-up. Clinical outcomes were assessed radiographically and with the Scoliosis Research Society-22 (SRS-22) score. Related complications were also recorded. The mean Cobb angle of the main curve was 62.4° (46°-98°) before surgery and 18.2° (9°-33°) at the most recent follow-up (average correction 73.3%). The compensatory cranial curve was corrected from 28.5° (11°-52°) to 9.1° (0°-30°) (average correction 70.0%). The compensatory caudal curve was corrected from 31.6° (14°-54°) to 6.9°(0°-19°) (average correction 79.1%). The segmental kyphosis/lordosis was corrected from 41.1° (-40° to 98°) to 12.3° (-25° to 41°) (average correction 65.5%). The mean growth rate of the T1-S1 length in immature patients was 9.8mm/year during the follow-up period. Health-related quality of life (SRS-22 score) had significantly improved. Complications include one wound infection and one developing deformity. One-stage posterior hemivertebral resection for unbalanced multiple hemivertebrae provides good radiographic and clinical outcomes with no severe complications when performed by an experienced surgeon. Longer follow-up to detect late complications is obligatory. Copyright © 2017 Elsevier B.V. All rights reserved.

Shuttle Ku-band signal design study

NASA Technical Reports Server (NTRS)

Lindsey, W. C.; Braun, W. R.; Mckenzie, T. M.

1978-01-01

Carrier synchronization and data demodulation of Unbalanced Quadriphase Shift Keyed (UQPSK) Shuttle communications' signals by optimum and suboptimum methods are discussed. The problem of analyzing carrier reconstruction techniques for unbalanced QPSK signal formats is addressed. An evaluation of the demodulation approach of the Ku-Band Shuttle return link for UQPSK when the I-Q channel power ratio is large is carried out. The effects that Shuttle rocket motor plumes have on the RF communications are determined also. The effect of data asymmetry on bit error probability is discussed.

Impact of ballistic body armour and load carriage on walking patterns and perceived comfort.

PubMed

Park, Huiju; Branson, Donna; Petrova, Adriana; Peksoz, Semra; Jacobson, Bert; Warren, Aric; Goad, Carla; Kamenidis, Panagiotis

2013-01-01

This study investigated the impact of weight magnitude and distribution of body armour and carrying loads on military personnel's walking patterns and comfort perceptions. Spatio-temporal parameters of walking, plantar pressure and contact area were measured while seven healthy male right-handed military students wore seven different garments of varying weight (0.06, 9, 18 and 27 kg) and load distribution (balanced and unbalanced, on the front and back torso). Higher weight increased the foot contact time with the floor. In particular, weight placement on the non-dominant side of the front torso resulted in the greatest stance phase and double support. Increased plantar pressure and contact area observed during heavier loads entail increased impact forces, which can cause overuse injuries and foot blisters. Participants reported increasingly disagreeable pressure and strain in the shoulder, neck and lower back during heavier weight conditions and unnatural walking while wearing unbalanced weight distributed loads. This study shows the potentially synergistic impact of wearing body armour vest with differential loads on body movement and comfort perception. This study found that soldiers should balance loads, avoiding load placement on the non-dominant side front torso, thus minimising mobility restriction and potential injury risk. Implications for armour vest design modifications can also be found in the results.

Simulation-based power calculation for designing interrupted time series analyses of health policy interventions.

PubMed

Zhang, Fang; Wagner, Anita K; Ross-Degnan, Dennis

2011-11-01

Interrupted time series is a strong quasi-experimental research design to evaluate the impacts of health policy interventions. Using simulation methods, we estimated the power requirements for interrupted time series studies under various scenarios. Simulations were conducted to estimate the power of segmented autoregressive (AR) error models when autocorrelation ranged from -0.9 to 0.9 and effect size was 0.5, 1.0, and 2.0, investigating balanced and unbalanced numbers of time periods before and after an intervention. Simple scenarios of autoregressive conditional heteroskedasticity (ARCH) models were also explored. For AR models, power increased when sample size or effect size increased, and tended to decrease when autocorrelation increased. Compared with a balanced number of study periods before and after an intervention, designs with unbalanced numbers of periods had less power, although that was not the case for ARCH models. The power to detect effect size 1.0 appeared to be reasonable for many practical applications with a moderate or large number of time points in the study equally divided around the intervention. Investigators should be cautious when the expected effect size is small or the number of time points is small. We recommend conducting various simulations before investigation. Copyright © 2011 Elsevier Inc. All rights reserved.

Technology Development for a Stirling Radioisotope Power System

NASA Technical Reports Server (NTRS)

Thieme, Lanny G.; Qiu, Songgang; White, Maurice A.

2000-01-01

NASA Glenn Research Center and the Department of Energy are developing a Stirling convertor for an advanced radioisotope power system to provide spacecraft on-board electric power for NASA deep space missions. NASA Glenn is addressing key technology issues through the use of two NASA Phase II SBIRs with Stirling Technology Company (STC) of Kennewick, WA. Under the first SBIR, STC demonstrated a synchronous connection of two thermodynamically independent free-piston Stirling convertors and a 40 to 50 fold reduction in vibrations compared to an unbalanced convertor. The second SBIR is for the development of an Adaptive Vibration Reduction System (AVRS) that will essentially eliminate vibrations over the mission lifetime, even in the unlikely event of a failed convertor. This paper presents the status and results for these two SBIR projects and also discusses a new NASA Glenn in-house project to provide supporting technology for the overall Stirling radioisotope power system development. Tasks for this new effort include convertor performance verification, controls development, heater head structural life assessment, magnet characterization and thermal aging tests, FEA analysis for a lightweight alternator concept, and demonstration of convertor operation under launch and orbit transfer load conditions.

A plea for a more physiological ICSI.

PubMed

Ebner, T; Filicori, M; Tews, G; Parmegiani, L

2012-05-01

Intracytoplasmic sperm injection (ICSI) can be considered the most 'revolutionary' in vitro insemination technique because it has efficiently allowed the treatment of male factor infertility. Although ICSI has been successfully and safely applied worldwide for almost 20 years, currently, we have no real knowledge regarding the hypothetical long-term side effects on ICSI adults, given the increased likelihood of spermatozoa with defective nuclear content fertilising the oocytes. The aim of this review article is to investigate the most recent advances of performing ICSI in the safest possible manner, thus, minimising the theoretical hazards of this procedure. To allow for substantiated recommendation which male gametes to choose for physiological ICSI an updated search was performed in Medline and Embase, from 1996 to June 2011. Recent technical advances allow operators to more or less simulate physiological conditions in the laboratory, reducing potential damage to the gametes. It seems possible to prevent fertilisation by DNA-damaged and chromosomal-unbalanced spermatozoa by selecting ICSI sperm by motility and/or maturation markers such as hyaluronic acid or other zona pellucida receptors. Furthermore, novel non-invasive imaging techniques can be valid tools for helping in the morphological selection of ICSI spermatozoa. © 2011 Blackwell Verlag GmbH.

Parallel Harmony Search Based Distributed Energy Resource Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ceylan, Oguzhan; Liu, Guodong; Tomsovic, Kevin

2015-01-01

This paper presents a harmony search based parallel optimization algorithm to minimize voltage deviations in three phase unbalanced electrical distribution systems and to maximize active power outputs of distributed energy resources (DR). The main contribution is to reduce the adverse impacts on voltage profile during a day as photovoltaics (PVs) output or electrical vehicles (EVs) charging changes throughout a day. The IEEE 123- bus distribution test system is modified by adding DRs and EVs under different load profiles. The simulation results show that by using parallel computing techniques, heuristic methods may be used as an alternative optimization tool in electricalmore » power distribution systems operation.« less

A model for characterizing residential ground current and magnetic field fluctuations.

PubMed

Mader, D L; Peralta, S B; Sherar, M D

1994-01-01

The current through the residential grounding circuit is an important source for magnetic fields; field variations near the grounding circuit accurately track fluctuations in this ground current. In this paper, a model is presented which permits calculation of the range of these fluctuations. A discrete network model is used to simulate a local distribution system for a single street, and a statistical model to simulate unbalanced currents in the system. Simulations of three-house and ten-house networks show that random appliance operation leads to ground current fluctuations which can be quite large, on the order of 600%. This is consistent with measured fluctuations in an actual house.

Inheritance of a Balanced t(12;20)(q24.33;p12.2) and Unbalanced der(13)t(7;13)(p21.3;q33.2) from a Maternally Derived Double Balanced Translocation Carrier.

PubMed

Peterson, Jess F; Geddes, Gabrielle C; Basel, Donald G; Schippman, Dana; Grignon, John W; vanTuinen, Peter; Kappes, Ulrike P

2018-03-01

We report a 4-month-old male proband with a history of prominent forehead, hypertelorism, ear abnormalities, micrognathia, hypospadias, and multiple cardiac abnormalities. Initial microarray analysis detected a concurrent 7p21.3-p22.3 duplication and 13q33.2-q34 deletion indicating an unbalanced rearrangement. However, subsequent conventional cytogenetic studies only revealed what appeared to be a balanced t(12;20)(q24.33;p12.2). Fluorescence in situ hybridization (FISH) using chromosome-specific subtelomere probes confirmed the presence of an unbalanced der(13)t(7;13)(p21.3;q33.2) and balanced t(12;20)(q24.33;p12.2), both of maternal origin. In addition to our unique clinical findings, this case highlights the benefits and limitations of both conventional cytogenetic studies and microarray analysis and how FISH complements each methodology.

Equatorial cloud level convection on Venus

NASA Astrophysics Data System (ADS)

Lee, Yeon Joo; Imamura, Takeshi; Sugiyama, Koichiro; Sato, Takao M.; Maejima, Yasumitsu

2016-10-01

In the equatorial region on Venus, a clear cloud top morphology difference depending on solar local time has been observed through UV images. Laminar flow shaped clouds are shown on the morning side, and convective-like cells on the afternoon side (Titov et al. 2012). Baker et al. (1998) suggested that deep convective motions in the low-to-middle cloud layers at the 40-60 km range can explain cellular shapes. Imamura et al. (2014), however argued that this cannot be a reason, as convection in the low-to-middle cloud layers can be suppressed near sub solar regions due to a stabilizing effect by strong solar heating. We suggest that the observed feature may be related to strong solar heating at local noon time (Lee et al. 2015). Horizontal uneven distribution of an unknown UV absorber and/or cloud top structure may trigger horizontal convection (Toigo et al. 1994). In order to examine these possibilities, we processed 1-D radiative transfer model calculations from surface to 100 km altitude (SHDOM, Evans 1998), which includes clouds at 48-71 km altitudes (Crisp et al. 1986). The results on the equatorial thermal cooling and solar heating profiles were employed in a 2D fluid dynamic model calculation (CReSS, Tsuboki and Sakakibara 2007). The calculation covered an altitude range of 40-80 km and a 100-km horizontal distance. We compared three conditions; an 'effective' global circulation condition that cancels out unbalanced net radiative energy at equator, a condition without such global circulation effect, and the last condition assumed horizontally inhomogeneous unknown UV absorber distribution. Our results show that the local time dependence of lower level cloud convection is consistent with Imamura et al.'s result, and suggest a possible cloud top level convection caused by locally unbalanced net energy and/or horizontally uneven solar heating. This may be related to the observed cloud morphology in UV images. The effective global circulation condition, however, can "remove" such cloud top level convection. The later one consists with measured high static stability at the cloud top level from radio occultation measurement.

Unbalanced 5;16 translocation in a boy with papillary thyroid carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, M.; Maynard, S.; Sheldon, S.

This is the first reported case of an unbalanced chromosome rearrangement resulting in trisomy 5q35.5{r_arrow}qter and monosomy 16p 13.3{r_arrow}pter, in a boy with mental and growth retardation, minor anomalies, and a history of bilateral papillary thyroid carcinoma. This was the result of a familial balanced translocation. The clinical and cytogenetic manifestations of the case are presented and the possible role of the chromosomal rearrangement in the etiology of the thyroid carcinoma is discussed. 25 refs., 5 figs., 1 tab.

Applying PWM to control overcurrents at unbalanced faults of force-commutated VSCs used as static var compensators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, Y.; Ekstroem, A.

1997-01-01

This study is devoted to investigating the possibility of controlling the overcurrent of a forced-commutated voltage source converter (VSC) by PWM when the ac system is undergoing large unbalanced disturbance. The converter is supposed to be used as a static var compensator at a high power level. A novel control strategy is proposed for controlling the reactive current and the dc side voltage independently. Digital simulation results are presented and compared with the results by using just the reactive current control with fundamental switching frequency.

Analysis of the unbalanced NBI rotation experiments in the ISX-B, PLT and PDX tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stacey, W.M. Jr.; Ryu, C.M.; Malik, M.A.

1985-07-01

The recently developed Stacey-Sigmar theory for toroidal momentum confinement, which is based upon neoclassical gyroviscosity, has been applied to the analysis of the unbalanced NBI rotation experiments in ISX-B, PLT and PDX. Measured steady-state rotation velocities, momentum confinement times inferred therefrom and momentum confinement times inferred from rotation decay after termination of NBI were compared with theoretical predictions. Good agreement between theory and experiment was obtained over a wide range of the parameters which enter the theory (R,Z,T,B).

Joint quantum measurement using unbalanced array detection.

PubMed

Beck, M; Dorrer, C; Walmsley, I A

2001-12-17

We have measured the joint Q-function of a highly multimode field using unbalanced heterodyne detection with a charge-coupled device array detector. We use spectral interferometry between a weak signal field and a strong, 100 fs duration local oscillator pulse to reconstruct the joint quadrature amplitude statistics of about 25 temporal modes. By adjusting the time delay between the signal and local oscillator pulses we are able to shift all the classical noise to modes distinct from the signal. This obviates the need to use a balanced detector.

Performance of unbalanced QPSK in the presence of noisy reference and crosstalk

NASA Technical Reports Server (NTRS)

Divsalar, D.; Yuen, J. H.

1979-01-01

The problem of transmitting two telemetry data streams having different rates and different powers using unbalanced quadriphase shift keying (UQPSK) signaling is considered. It is noted that the presence of a noisy carrier phase reference causes a degradation in detection performance in coherent communications systems and that imperfect carrier synchronization not only attenuates the main demodulated signal voltage in UQPSK but also produces interchannel interference (crosstalk) which degrades the performance still further. Exact analytical expressions for symbol error probability of UQPSK in the presence of noise phase reference are derived.

Load-Flow in Multiphase Distribution Networks: Existence, Uniqueness, Non-Singularity, and Linear Models

DOE PAGES

Bernstein, Andrey; Wang, Cong; Dall'Anese, Emiliano; ...

2018-01-01

This paper considers unbalanced multiphase distribution systems with generic topology and different load models, and extends the Z-bus iterative load-flow algorithm based on a fixed-point interpretation of the AC load-flow equations. Explicit conditions for existence and uniqueness of load-flow solutions are presented. These conditions also guarantee convergence of the load-flow algorithm to the unique solution. The proposed methodology is applicable to generic systems featuring (i) wye connections; (ii) ungrounded delta connections; (iii) a combination of wye-connected and delta-connected sources/loads; and, (iv) a combination of line-to-line and line-to-grounded-neutral devices at the secondary of distribution transformers. Further, a sufficient condition for themore » non-singularity of the load-flow Jacobian is proposed. Finally, linear load-flow models are derived, and their approximation accuracy is analyzed. Theoretical results are corroborated through experiments on IEEE test feeders.« less

Load-Flow in Multiphase Distribution Networks: Existence, Uniqueness, Non-Singularity, and Linear Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernstein, Andrey; Wang, Cong; Dall'Anese, Emiliano

This paper considers unbalanced multiphase distribution systems with generic topology and different load models, and extends the Z-bus iterative load-flow algorithm based on a fixed-point interpretation of the AC load-flow equations. Explicit conditions for existence and uniqueness of load-flow solutions are presented. These conditions also guarantee convergence of the load-flow algorithm to the unique solution. The proposed methodology is applicable to generic systems featuring (i) wye connections; (ii) ungrounded delta connections; (iii) a combination of wye-connected and delta-connected sources/loads; and, (iv) a combination of line-to-line and line-to-grounded-neutral devices at the secondary of distribution transformers. Further, a sufficient condition for themore » non-singularity of the load-flow Jacobian is proposed. Finally, linear load-flow models are derived, and their approximation accuracy is analyzed. Theoretical results are corroborated through experiments on IEEE test feeders.« less

Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome.

PubMed

Volkert, Sarah; Kohlmann, Alexander; Schnittger, Susanne; Kern, Wolfgang; Haferlach, Torsten; Haferlach, Claudia

2014-05-01

We analyzed 1,200 patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) harboring a 5q deletion in order to clarify whether the type of 5q loss is associated with other biological markers and prognosis. We investigated all patients by chromosome banding analysis, FISH with a probe for EGR1 (5q31) and, if necessary, to resolve complex karyotypes with 24-color-FISH. Moreover, 420 patients were analyzed for mutations in the TP53 gene. The patient cohort was subdivided based on type of 5q loss: Patients with interstitial deletions and patients with 5q loss due to unbalanced rearrangements or monosomy 5. Loss of the long arm of chromosome 5 due to an unbalanced rearrangement occurred more often in AML (286/627; 45.6%) than MDS (188/573; 32.8%; P < 0.001). In both entities, patients with 5q loss due to unbalanced translocations showed complex karyotypes more frequently (MDS: 179/188; 95.2% vs. 124/385; 32.2%; P < 0.001; AML: 274/286; 95.8% vs. 256/341; 75.1%; P < 0.001). Moreover, in MDS unbalanced 5q translocations were associated with clonal evolution (109/188; 58.0% vs. 124/385; 32.2%; P < 0.001), mutation of TP53 (64/67; 95.5% vs. 40/120; 40.0%; P < 0.001), and shorter survival (15.3 months vs. not reached; P < 0.001). In MDS, complex karyotype was an independent adverse prognostic factor (HR = 5.34; P = 0.032), whereas in AML presence of TP53 mutations was the strongest adverse prognostic factor (HR = 2.21; P = 0.026). In conclusion, in AML and MDS, loss of the long arm of chromosome 5 due to unbalanced translocations is associated with complex karyotype and in MDS, moreover, with clonal evolution, mutations in the TP53 gene and adverse prognosis. Copyright © 2014 Wiley Periodicals, Inc.

Improving Distribution Resiliency with Microgrids and State and Parameter Estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuffner, Francis K.; Williams, Tess L.; Schneider, Kevin P.

Modern society relies on low-cost reliable electrical power, both to maintain industry, as well as provide basic social services to the populace. When major disturbances occur, such as Hurricane Katrina or Hurricane Sandy, the nation’s electrical infrastructure can experience significant outages. To help prevent the spread of these outages, as well as facilitating faster restoration after an outage, various aspects of improving the resiliency of the power system are needed. Two such approaches are breaking the system into smaller microgrid sections, and to have improved insight into the operations to detect failures or mis-operations before they become critical. Breaking themore » system into smaller sections of microgrid islands, power can be maintained in smaller areas where distribution generation and energy storage resources are still available, but bulk power generation is no longer connected. Additionally, microgrid systems can maintain service to local pockets of customers when there has been extensive damage to the local distribution system. However, microgrids are grid connected a majority of the time and implementing and operating a microgrid is much different than when islanded. This report discusses work conducted by the Pacific Northwest National Laboratory that developed improvements for simulation tools to capture the characteristics of microgrids and how they can be used to develop new operational strategies. These operational strategies reduce the cost of microgrid operation and increase the reliability and resilience of the nation’s electricity infrastructure. In addition to the ability to break the system into microgrids, improved observability into the state of the distribution grid can make the power system more resilient. State estimation on the transmission system already provides great insight into grid operations and detecting abnormal conditions by leveraging existing measurements. These transmission-level approaches are expanded to using advanced metering infrastructure and other distribution-level measurements to create a three-phase, unbalanced distribution state estimation approach. With distribution-level state estimation, the grid can be operated more efficiently, and outages or equipment failures can be caught faster, improving the overall resilience and reliability of the grid.« less

Recommendations for choosing an analysis method that controls Type I error for unbalanced cluster sample designs with Gaussian outcomes.

PubMed

Johnson, Jacqueline L; Kreidler, Sarah M; Catellier, Diane J; Murray, David M; Muller, Keith E; Glueck, Deborah H

2015-11-30

We used theoretical and simulation-based approaches to study Type I error rates for one-stage and two-stage analytic methods for cluster-randomized designs. The one-stage approach uses the observed data as outcomes and accounts for within-cluster correlation using a general linear mixed model. The two-stage model uses the cluster specific means as the outcomes in a general linear univariate model. We demonstrate analytically that both one-stage and two-stage models achieve exact Type I error rates when cluster sizes are equal. With unbalanced data, an exact size α test does not exist, and Type I error inflation may occur. Via simulation, we compare the Type I error rates for four one-stage and six two-stage hypothesis testing approaches for unbalanced data. With unbalanced data, the two-stage model, weighted by the inverse of the estimated theoretical variance of the cluster means, and with variance constrained to be positive, provided the best Type I error control for studies having at least six clusters per arm. The one-stage model with Kenward-Roger degrees of freedom and unconstrained variance performed well for studies having at least 14 clusters per arm. The popular analytic method of using a one-stage model with denominator degrees of freedom appropriate for balanced data performed poorly for small sample sizes and low intracluster correlation. Because small sample sizes and low intracluster correlation are common features of cluster-randomized trials, the Kenward-Roger method is the preferred one-stage approach. Copyright © 2015 John Wiley & Sons, Ltd.

Distribution of magnesium in central nervous system tissue, trabecular and cortical bone in rats fed with unbalanced diets of minerals.

PubMed

Yasui, M; Yano, I; Yase, Y; Ota, K

1990-11-01

Recent epidemiological changes in patterns of foci of amyotrophic lateral sclerosis (ALS) in the Western Pacific suggest that environmental factors play a contributory role in the pathogenic process of this disorder. In this experimental study on rats, a similar situation of dietary mineral imbalance was created as is found in the soil and drinking water of these ALS foci with a low content of calcium (Ca) and magnesium (Mg) and a high content of aluminum (Al). In groups of rats fed a low Ca diet, low Ca-Mg diet, and low Ca-Mg plus high Al diet, serum Ca levels were found to be lower than those in a group fed a standard diet. Also, serum Mg levels were lower in the groups fed a low Ca-Mg diet and a low Ca-Mg plus high Al diet than in the groups fed a standard diet and only a low Ca diet. There was no significant difference in Mg content of central nervous system (CNS) tissues of groups fed unbalanced and standard diets, except for a significant decrease in Mg content of the spinal cord of rats fed a low Ca-Mg plus high Al diet. Mg content of the lumbar spine and cortical bone decreased in the unbalanced diet groups compared with that of a group fed a standard diet. These findings suggest that under the disturbed bone mineralization induced by unbalanced mineral diets, Mg may be mobilized from bone to maintain the level necessary for vital activity in soft tissues including CNS tissue.

Deletion of FPS1, Encoding Aquaglyceroporin Fps1p, Improves Xylose Fermentation by Engineered Saccharomyces cerevisiae

PubMed Central

Wei, Na; Xu, Haiqing; Kim, Soo Rin

2013-01-01

Accumulation of xylitol in xylose fermentation with engineered Saccharomyces cerevisiae presents a major problem that hampers economically feasible production of biofuels from cellulosic plant biomass. In particular, substantial production of xylitol due to unbalanced redox cofactor usage by xylose reductase (XR) and xylitol dehydrogenase (XDH) leads to low yields of ethanol. While previous research focused on manipulating intracellular enzymatic reactions to improve xylose metabolism, this study demonstrated a new strategy to reduce xylitol formation and increase carbon flux toward target products by controlling the process of xylitol secretion. Using xylitol-producing S. cerevisiae strains expressing XR only, we determined the role of aquaglyceroporin Fps1p in xylitol export by characterizing extracellular and intracellular xylitol. In addition, when FPS1 was deleted in a poorly xylose-fermenting strain with unbalanced XR and XDH activities, the xylitol yield was decreased by 71% and the ethanol yield was substantially increased by nearly four times. Experiments with our optimized xylose-fermenting strain also showed that FPS1 deletion reduced xylitol production by 21% to 30% and increased ethanol yields by 3% to 10% under various fermentation conditions. Deletion of FPS1 decreased the xylose consumption rate under anaerobic conditions, but the effect was not significant in fermentation at high cell density. Deletion of FPS1 resulted in higher intracellular xylitol concentrations but did not significantly change the intracellular NAD+/NADH ratio in xylose-fermenting strains. The results demonstrate that Fps1p is involved in xylitol export in S. cerevisiae and present a new gene deletion target, FPS1, and a mechanism different from those previously reported to engineer yeast for improved xylose fermentation. PMID:23475614

GWAS with longitudinal phenotypes: performance of approximate procedures

PubMed Central

Sikorska, Karolina; Montazeri, Nahid Mostafavi; Uitterlinden, André; Rivadeneira, Fernando; Eilers, Paul HC; Lesaffre, Emmanuel

2015-01-01

Analysis of genome-wide association studies with longitudinal data using standard procedures, such as linear mixed model (LMM) fitting, leads to discouragingly long computation times. There is a need to speed up the computations significantly. In our previous work (Sikorska et al: Fast linear mixed model computations for genome-wide association studies with longitudinal data. Stat Med 2012; 32.1: 165–180), we proposed the conditional two-step (CTS) approach as a fast method providing an approximation to the P-value for the longitudinal single-nucleotide polymorphism (SNP) effect. In the first step a reduced conditional LMM is fit, omitting all the SNP terms. In the second step, the estimated random slopes are regressed on SNPs. The CTS has been applied to the bone mineral density data from the Rotterdam Study and proved to work very well even in unbalanced situations. In another article (Sikorska et al: GWAS on your notebook: fast semi-parallel linear and logistic regression for genome-wide association studies. BMC Bioinformatics 2013; 14: 166), we suggested semi-parallel computations, greatly speeding up fitting many linear regressions. Combining CTS with fast linear regression reduces the computation time from several weeks to a few minutes on a single computer. Here, we explore further the properties of the CTS both analytically and by simulations. We investigate the performance of our proposal in comparison with a related but different approach, the two-step procedure. It is analytically shown that for the balanced case, under mild assumptions, the P-value provided by the CTS is the same as from the LMM. For unbalanced data and in realistic situations, simulations show that the CTS method does not inflate the type I error rate and implies only a minimal loss of power. PMID:25712081

Is classic pericentric inversion of chromosome 2 inv(2)(p11q13) associated with an increased risk of unbalanced chromosomes?

PubMed

Ferfouri, Fatma; Clement, Patrice; Gomes, Denise Molina; Minz, Marie; Amar, Edouard; Selva, Jacqueline; Vialard, François

2009-10-01

To study pericentric inversion segregation and interchromosomal effect on sperm for men heterozygous for inv(2)(p11q13), to assess the risk of miscarriage. Case report. Department of reproductive biology, cytogenetics, gynecology, and obstetrics. Seven patients heterozygous for inv(2)(p11q13) and five patients with normal karyotype with experience of recurrent spontaneous miscarriage. Fluorescence in situ hybridization on sperm with 2 p and 2q subtelomeric probes to screen for inversion segregation, and X, Y, and 18 centromeric probes to study interchromosomal effects. One thousand sperm were analyzed per experiment and per patient. Rate of unbalanced chromosomes and aneuploid sperm. The inv(2)(p11q13) patients showed a 0.3% rate of sperm with unbalanced chromosomes. For interchromosomal effects, a 0.6% aneuploid sperm rate was observed for patients heterozygous for inv(2)(p11q13). This is similar to the 0.5% rate observed for control patients. Inv(2)(p11q13) seems not to increase miscarriage for couples with men heterozygous for this inversion.

Fabrication and characterization of self-folding thermoplastic sheets using unbalanced thermal shrinkage.

PubMed

Danielson, Christian; Mehrnezhad, Ali; YekrangSafakar, Ashkan; Park, Kidong

2017-06-14

Self-folding or micro-origami technologies are actively investigated as a novel manufacturing process to fabricate three-dimensional macro/micro-structures. In this paper, we present a simple process to produce a self-folding structure with a biaxially oriented polystyrene sheet (BOPS) or Shrinky Dinks. A BOPS sheet is known to shrink to one-third of its original size in plane, when it is heated above 160 °C. A grid pattern is engraved on one side of the BOPS film with a laser engraver to decrease the thermal shrinkage of the engraved side. The thermal shrinkage of the non-engraved side remains the same and this unbalanced thermal shrinkage causes folding of the structure as the structure shrinks at high temperature. We investigated the self-folding mechanism and characterized how the grid geometry, the grid size, and the power of the laser engraver affect the bending curvature. The developed fabrication process to locally modulate thermomechanical properties of the material by engraving the grid pattern and the demonstrated design methodology to harness the unbalanced thermal shrinkage can be applied to develop complicated self-folding macro/micro structures.

On the Effects of a Spacecraft Subcarrier Unbalanced Modulator

NASA Technical Reports Server (NTRS)

Nguyen, Tien Manh

1993-01-01

This paper presents mathematical models with associated analysis of the deleterious effects which a spacecraft's subcarrier unbalanced modulator has on the performance of a phase-modulated residual carrier communications link. The undesired spectral components produced by the phase and amplitude imbalances in the subcarrier modulator can cause (1) potential interference to the carrier tracking and (2) degradation in the telemetry bit signal-to-noise ratio (SNR). A suitable model for the unbalanced modulator is developed and the threshold levels of undesired components that fall into the carrier tracking loop are determined. The distribution of the carrier phase error caused by the additive White Gaussian noise (AWGN) and undesired component at the residual RF carrier is derived for the limiting cases. Further, this paper analyses the telemetry bit signal-to-noise ratio degradations due to undesirable spectral components as well as the carrier tracking phase error induced by phase and amplitude imbalances. Numerical results which indicate the sensitivity of the carrier tracking loop and the telemetry symbol-error rate (SER) to various parameters of the models are also provided as a tool in the design of the subcarrier balanced modulator.

The dentist’s operating posture – ergonomic aspects

PubMed Central

Pîrvu, C; Pătraşcu, I; Pîrvu, D; Ionescu, C

2014-01-01

Abstract The practice of dentistry involves laborious high finesse dental preparations, precision and control in executions that require a particular attention, concentration and patience of the dentist and finally the dentist’s physical and mental resistance. The optimal therapeutic approach and the success of practice involve special working conditions for the dentist and his team in an ergonomic environment. The meaning of the posture in ergonomics is the manner in which different parts of the body are located and thus the reports are established between them in order to allow a special task execution. This article discusses the posture adopted by dentists when they work, beginning with the balanced posture and going to different variants of posture. The ideal posture of a dentist gives him, on the one hand the optimal working conditions (access, visibility and control in the mouth) and on the other hand, physical and psychological comfort throughout the execution of the clinical acts. Although the theme of dentist posture is treated with great care and often presented in the undergraduate courses and the continuing education courses on ergonomics in dentistry, many dentists do not know the subject well enough nor the theoretical issues and therefore nor the practical applicability. The risk and perspective of the musculoskeletal disorders related to unbalanced postures should determine the dentists take postural corrective actions and compensation measures in order to limit the negative effects of working in a bad posture. PMID:25184007

Tensile-stressed microelectromechanical apparatus and microelectromechanical relay formed therefrom

DOEpatents

Fleming, James G [Albuquerque, NM

2008-03-04

A microelectromechanical (MEM) apparatus is disclosed which includes a shuttle suspended above a substrate by two or more sets of tensile-stressed beams which are operatively connected to the shuttle and which can comprise tungsten or a silicon nitride/polysilicon composite structure. Initially, the tensile stress in each set of beams is balanced. However, the tensile stress can be unbalanced by heating one or more of the sets of beams; and this can be used to move the shuttle over a distance of up to several tens of microns. The MEM apparatus can be used to form a MEM relay having relatively high contact and opening forces, and with or without a latching capability.

Definition and design of an experiment to test raster scanning with rotating unbalanced-mass devices on gimbaled payloads

NASA Technical Reports Server (NTRS)

Lightsey, W. D.; Alhorn, D. C.; Polites, M. E.

1992-01-01

An experiment designed to test the feasibility of using rotating unbalanced-mass (RUM) devices for line and raster scanning gimbaled payloads, while expending very little power is described. The experiment is configured for ground-based testing, but the scan concept is applicable to ground-based, balloon-borne, and space-based payloads, as well as free-flying spacecraft. The servos used in scanning are defined; the electronic hardware is specified; and a computer simulation model of the system is described. Simulation results are presented that predict system performance and verify the servo designs.

Incomplete Detection of Nonclassical Phase-Space Distributions

NASA Astrophysics Data System (ADS)

Bohmann, M.; Tiedau, J.; Bartley, T.; Sperling, J.; Silberhorn, C.; Vogel, W.

2018-02-01

We implement the direct sampling of negative phase-space functions via unbalanced homodyne measurement using click-counting detectors. The negativities significantly certify nonclassical light in the high-loss regime using a small number of detectors which cannot resolve individual photons. We apply our method to heralded single-photon states and experimentally demonstrate the most significant certification of nonclassicality for only two detection bins. By contrast, the frequently applied Wigner function fails to directly indicate such quantum characteristics for the quantum efficiencies present in our setup without applying additional reconstruction algorithms. Therefore, we realize a robust and reliable approach to characterize nonclassical light in phase space under realistic conditions.

Surfactant effects on contact line alteration of a liquid drop in a capillary tube

NASA Astrophysics Data System (ADS)

Yulianti, K.; Marwati, R.

2018-05-01

In this paper, the effect of an insoluble surfactant on the moving contact line of an interface between two fluids filling a capillary tube is studied. The governing equations are the incompressible Navier-Stokes equations with the couple of Eulerian fluid variables and Lagrangian interfacial markers. In our model, capillary force plays a role in the fluids motion. Here, we propose that besides lowering the interfacial tension which affects the capillary force, the surfactant also decreases the surface tension between fluids and a solid surface. That condition is applied to the unbalanced Young condition at the contact line. The front-tracking method is used to solve numerically the free boundary motion of the interface. Results show that the surfactant has a significant effect on the motion of the contact line.

Advanced Energy Storage Management in Distribution Network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Guodong; Ceylan, Oguzhan; Xiao, Bailu

2016-01-01

With increasing penetration of distributed generation (DG) in the distribution networks (DN), the secure and optimal operation of DN has become an important concern. In this paper, an iterative mixed integer quadratic constrained quadratic programming model to optimize the operation of a three phase unbalanced distribution system with high penetration of Photovoltaic (PV) panels, DG and energy storage (ES) is developed. The proposed model minimizes not only the operating cost, including fuel cost and purchasing cost, but also voltage deviations and power loss. The optimization model is based on the linearized sensitivity coefficients between state variables (e.g., node voltages) andmore » control variables (e.g., real and reactive power injections of DG and ES). To avoid slow convergence when close to the optimum, a golden search method is introduced to control the step size and accelerate the convergence. The proposed algorithm is demonstrated on modified IEEE 13 nodes test feeders with multiple PV panels, DG and ES. Numerical simulation results validate the proposed algorithm. Various scenarios of system configuration are studied and some critical findings are concluded.« less

Time-domain least-squares migration using the Gaussian beam summation method

NASA Astrophysics Data System (ADS)

Yang, Jidong; Zhu, Hejun; McMechan, George; Yue, Yubo

2018-04-01

With a finite recording aperture, a limited source spectrum and unbalanced illumination, traditional imaging methods are insufficient to generate satisfactory depth profiles with high resolution and high amplitude fidelity. This is because traditional migration uses the adjoint operator of the forward modeling rather than the inverse operator. We propose a least-squares migration approach based on the time-domain Gaussian beam summation, which helps to balance subsurface illumination and improve image resolution. Based on the Born approximation for the isotropic acoustic wave equation, we derive a linear time-domain Gaussian beam modeling operator, which significantly reduces computational costs in comparison with the spectral method. Then, we formulate the corresponding adjoint Gaussian beam migration, as the gradient of an L2-norm waveform misfit function. An L1-norm regularization is introduced to the inversion to enhance the robustness of least-squares migration, and an approximated diagonal Hessian is used as a preconditioner to speed convergence. Synthetic and field data examples demonstrate that the proposed approach improves imaging resolution and amplitude fidelity in comparison with traditional Gaussian beam migration.

Time-domain least-squares migration using the Gaussian beam summation method

NASA Astrophysics Data System (ADS)

Yang, Jidong; Zhu, Hejun; McMechan, George; Yue, Yubo

2018-07-01

With a finite recording aperture, a limited source spectrum and unbalanced illumination, traditional imaging methods are insufficient to generate satisfactory depth profiles with high resolution and high amplitude fidelity. This is because traditional migration uses the adjoint operator of the forward modelling rather than the inverse operator. We propose a least-squares migration approach based on the time-domain Gaussian beam summation, which helps to balance subsurface illumination and improve image resolution. Based on the Born approximation for the isotropic acoustic wave equation, we derive a linear time-domain Gaussian beam modelling operator, which significantly reduces computational costs in comparison with the spectral method. Then, we formulate the corresponding adjoint Gaussian beam migration, as the gradient of an L2-norm waveform misfit function. An L1-norm regularization is introduced to the inversion to enhance the robustness of least-squares migration, and an approximated diagonal Hessian is used as a pre-conditioner to speed convergence. Synthetic and field data examples demonstrate that the proposed approach improves imaging resolution and amplitude fidelity in comparison with traditional Gaussian beam migration.

Transient analysis of unbalanced short circuits of the ERDA-NASA 100 kW wind turbine alternator

NASA Technical Reports Server (NTRS)

Hwang, H. H.; Gilbert, L. J.

1976-01-01

Unbalanced short-circuit faults on the alternator of the ERDA-NASA Mod-O100-kW experimental wind turbine are studied. For each case, complete solutions for armature, field, and damper-circuit currents; short-circuit torque; and open-phase voltage are derived directly by a mathematical analysis. Formulated results are tabulated. For the Mod-O wind turbine alternator, numerical calculations are given, and results are presented by graphs. Comparisons for significant points among the more important cases are summarized. For these cases the transients are found to be potentially severe. The effect of the alternator neutral-to-ground impedance is evaluated.

Trisomy 2q11.2-->q21.1 resulting from an unbalanced insertion in two generations.

PubMed Central

Glass, I A; Stormer, P; Oei, P T; Hacking, E; Cotter, P D

1998-01-01

In this communication, we describe two cases of proximal 2q trisomy (2q11.2--> q21.1) resulting from an interchromosomal insertion. The chromosomal origin of the insertion was confirmed by fluorescence in situ hybridisation. An unbalanced karyotype, 46,XX,der(8) ,ins(8;2) (p21.3; q21.1q11.2), was found in the proband and her mother, who both have mild mental retardation, short stature, dysmorphic features, insulin dependent diabetes mellitus, and a psychotic illness. This family is a rare example of direct transmission of a partial autosomal trisomy. Images PMID:9598728

A balancing act: physical balance, through arousal, influences size perception.

PubMed

Geuss, Michael N; Stefanucci, Jeanine K; de Benedictis-Kessner, Justin; Stevens, Nicholas R

2010-10-01

Previous research has demonstrated that manipulating vision influences balance. Here, we question whether manipulating balance can influence vision and how it may influence vision--specifically, the perception of width. In Experiment 1, participants estimated the width of beams while balanced and unbalanced. When unbalanced, participants judged the widths to be smaller. One possible explanation is that unbalanced participants did not view the stimulus as long as when balanced because they were focused on remaining balanced. In Experiment 2, we tested this notion by limiting viewing time. Experiment 2 replicated the findings of Experiment 1, but viewing time had no effect on width judgments. In Experiment 3, participants' level of arousal was manipulated, because the balancing task likely produced arousal. While jogging, participants judged the beams to be smaller. In Experiment 4, participants completed another arousing task (counting backward by sevens) that did not involve movement. Again, participants judged the beams to be smaller when aroused. Experiment 5A raised participants' level of arousal before estimating the board widths (to control for potential dual-task effects) and showed that heightened arousal still influenced perceived width of the boards. Collectively, heightened levels of arousal, caused by multiple manipulations (including balance), influenced perceived width.

[MicroRNA Target Prediction Based on Support Vector Machine Ensemble Classification Algorithm of Under-sampling Technique].

PubMed

Chen, Zhiru; Hong, Wenxue

2016-02-01

Considering the low accuracy of prediction in the positive samples and poor overall classification effects caused by unbalanced sample data of MicroRNA (miRNA) target, we proposes a support vector machine (SVM)-integration of under-sampling and weight (IUSM) algorithm in this paper, an under-sampling based on the ensemble learning algorithm. The algorithm adopts SVM as learning algorithm and AdaBoost as integration framework, and embeds clustering-based under-sampling into the iterative process, aiming at reducing the degree of unbalanced distribution of positive and negative samples. Meanwhile, in the process of adaptive weight adjustment of the samples, the SVM-IUSM algorithm eliminates the abnormal ones in negative samples with robust sample weights smoothing mechanism so as to avoid over-learning. Finally, the prediction of miRNA target integrated classifier is achieved with the combination of multiple weak classifiers through the voting mechanism. The experiment revealed that the SVM-IUSW, compared with other algorithms on unbalanced dataset collection, could not only improve the accuracy of positive targets and the overall effect of classification, but also enhance the generalization ability of miRNA target classifier.

The dependability of medical students' performance ratings as documented on in-training evaluations.

PubMed

van Barneveld, Christina

2005-03-01

To demonstrate an approach to obtain an unbiased estimate of the dependability of students' performance ratings during training, when the data-collection design includes nesting of student in rater, unbalanced nest sizes, and dependent observations. In 2003, two variance components analyses of in-training evaluation (ITE) report data were conducted using urGENOVA software. In the first analysis, the dependability for the nested and unbalanced data-collection design was calculated. In the second analysis, an approach using multiple generalizability studies was used to obtain an unbiased estimate of the student variance component, resulting in an unbiased estimate of dependability. Results suggested that there is bias in estimates of the dependability of students' performance on ITEs that are attributable to the data-collection design. When the bias was corrected, the results indicated that the dependability of ratings of student performance was almost zero. The combination of the multiple generalizability studies method and the use of specialized software provides an unbiased estimate of the dependability of ratings of student performance on ITE scores for data-collection designs that include nesting of student in rater, unbalanced nest sizes, and dependent observations.

Understanding the interplay of carbon and nitrogen supply for ectoines production and metabolic overflow in high density cultures of Chromohalobacter salexigens.

PubMed

Salar-García, María J; Bernal, Vicente; Pastor, José M; Salvador, Manuel; Argandoña, Montserrat; Nieto, Joaquín J; Vargas, Carmen; Cánovas, Manuel

2017-02-08

The halophilic bacterium Chromohalobacter salexigens has been proposed as promising cell factory for the production of the compatible solutes ectoine and hydroxyectoine. This bacterium has evolved metabolic adaptations to efficiently grow under high salt concentrations by accumulating ectoines as compatible solutes. However, metabolic overflow, which is a major drawback for the efficient conversion of biological feedstocks, occurs as a result of metabolic unbalances during growth and ectoines production. Optimal production of ectoines is conditioned by the interplay of carbon and nitrogen metabolisms. In this work, we set out to determine how nitrogen supply affects the production of ectoines. Chromohalobacter salexigens was challenged to grow in media with unbalanced carbon/nitrogen ratio. In C. salexigens, overflow metabolism and ectoines production are a function of medium composition. At low ammonium conditions, the growth rate decreased importantly, up to 80%. Shifts in overflow metabolism were observed when changing the C/N ratio in the culture medium. 13 C-NMR analysis of ectoines labelling revealed a high metabolic rigidity, with almost constant flux ratios in all conditions assayed. Unbalanced C/N ratio led to pyruvate accumulation, especially upon N-limitation. Analysis of an ect - mutant demonstrated the link between metabolic overflow and ectoine biosynthesis. Under non ectoine synthesizing conditions, glucose uptake and metabolic overflow decreased importantly. Finally, in fed-batch cultures, biomass yield was affected by the feeding scheme chosen. High growth (up to 42.4 g L -1 ) and volumetric ectoine yields (up to 4.21 g L -1 ) were obtained by minimizing metabolite overflow and nutrient accumulation in high density cultures in a low nitrogen fed-batch culture. Moreover, the yield coefficient calculated for the transformation of glucose into biomass was 30% higher in fed-batch than in the batch culture, demonstrating that the metabolic efficiency of C. salexigens can be improved by careful design of culture feeding schemes. Metabolic shifts observed at low ammonium concentrations were explained by a shift in the energy required for nitrogen assimilation. Carbon-limited fed-batch cultures with reduced ammonium supply were the best conditions for cultivation of C. salexigens, supporting high density growth and maintaining high ectoines production.

History dependent quantum walk on the cycle with an unbalanced coin

NASA Astrophysics Data System (ADS)

Krawec, Walter O.

2015-06-01

Recently, a new model of quantum walk, utilizing recycled coins, was introduced; however little is yet known about its properties. In this paper, we study its behavior on the cycle graph. In particular, we will consider its time averaged distribution and how it is affected by the walk's "memory parameter"-a real parameter, between zero and eight, which affects the walk's coin flip operator. Despite an infinite number of different parameters, our analysis provides evidence that only a few produce non-uniform behavior. Our analysis also shows that the initial state, and cycle size modulo four all affect the behavior of this walk. We also prove an interesting relationship between the recycled coin model and a different memory-based quantum walk recently proposed.

Traveling wave ultrasonic motor: coupling effects in free stator.

PubMed

Frayssignes, H; Briot, R

2003-03-01

Generally a stator of traveling wave ultrasonic motor (TWUM) consists of piezoelectric transducers (annular plate or rods) coupled by the way of a metallic ring. These transducers divided into halves are excited independently by two electrical signals with different phases of about 90 degrees. So an elastic traveling wave propagates along the circumference of the ring and a rotor pressed on this vibrating surface is then driven by the stator via contact forces. Many difficulties appear in developing TWUM because the contact between the stator and the rotor via a frictional material is very important. However that may be, the first stage consists in obtaining a vibrating stator with optimum characteristics with two symmetrical phases. The aim of this paper is to discuss some coupling effects in a free stator through an enhanced equivalent circuit model. A simple experimental method based on impedance measurements is performed to estimate the coupling characteristics at a low driving voltage. This paper reports results obtained with the free stator of the well known piezoelectric ultrasonic motor "USR60" by Shinsei Co. Ltd. Since the stator behaves as an elastic body, interactions between the two electrical inputs might be described by the introduction of a coupling oscillator. The comparison of experimental and theoretical results leads to validate the new equivalent circuit of the free stator. The presence of coupling impedance could imply a change of electrical supply condition to optimize the TWUM efficiency. The effects of unbalanced features for each electrical input and the applicability of the proposed model to actual operating condition are discussed in the paper. Copyright 2002 Elsevier Science B.V.

A unique case of growth hormone and human chorionic gonadotropin treatment in a 45,X male with Y: autosome translocation and literature review.

PubMed

Mareri, Arianna; Iezzi, MariaLaura; Salvatore, Alessia; Ligas, Claudio; D'Alessandro, Elvira

2016-07-01

Maleness associated with a 45,X karyotype is a rare condition in childhood. It is usually diagnosed in adult age because of infertility. We report a unique case of an unbalanced translocation t(Y;21) in a 14-year-old boy with 45,X karyotype referred because of short stature, thin habitus and puberty delay. Hormone analysis showed low serum levels of basal testosterone, insulin-like growth factor (IGF-I) and gonadotrophins. Diagnosis of GH deficiency and puberty delay were made. He was treated with human chorionic gonadotropin (hCG) and GH therapy, respectively, for 6 and 24 months.

Metabolic Bone Diseases and Total Hip Arthroplasty: Preventing Complications.

PubMed

Moya-Angeler, Joaquin; Lane, Joseph M; Rodriguez, Jose A

2017-11-01

Metabolic bone diseases are a diverse group of conditions characterized by abnormalities in calcium metabolism and/or bone cell physiology. These unbalanced processes can eventually lead to bony deformities and altered joint biomechanics, resulting in degenerative joint disease. Not infrequently, patients with metabolic bone diseases have restricting hip joint pain that ultimately necessitates hip arthroplasty. To minimize complications, the surgeon must consider the particular characteristics of these patients. The surgical and medical management of patients with metabolic bone diseases undergoing hip arthroplasty requires appropriate preoperative diagnosis, careful attention to the technical challenges of surgery, and strategies to maximize the long-term results of the surgical intervention, such as the use of bone anabolic and anticatabolic agents.

Demographic origins of skewed operational and adult sex ratios: perturbation analyses of two-sex models.

PubMed

Veran, Sophie; Beissinger, Steven R

2009-02-01

Skewed sex ratios - operational (OSR) and Adult (ASR) - arise from sexual differences in reproductive behaviours and adult survival rates due to the cost of reproduction. However, skewed sex-ratio at birth, sex-biased dispersal and immigration, and sexual differences in juvenile mortality may also contribute. We present a framework to decompose the roles of demographic traits on sex ratios using perturbation analyses of two-sex matrix population models. Metrics of sensitivity are derived from analyses of sensitivity, elasticity, life-table response experiments and life stage simulation analyses, and applied to the stable stage distribution instead of lambda. We use these approaches to examine causes of male-biased sex ratios in two populations of green-rumped parrotlets (Forpus passerinus) in Venezuela. Female local juvenile survival contributed the most to the unbalanced OSR and ASR due to a female-biased dispersal rate, suggesting sexual differences in philopatry can influence sex ratios more strongly than the cost of reproduction.

Computational model for calculating the dynamical behaviour of generators caused by unbalanced magnetic pull and experimental validation

NASA Astrophysics Data System (ADS)

Pennacchi, Paolo

2008-04-01

The modelling of the unbalanced magnetic pull (UMP) in generators and the experimental validation of the proposed method are presented in this paper. The UMP is one of the most remarkable effects of electromechanical interactions in rotating machinery. As a consequence of the rotor eccentricity, the imbalance of the electromagnetic forces acting between rotor and stator generates a net radial force. This phenomenon can be avoided by means of a careful assembly and manufacture in small and stiff machines, like electrical motors. On the contrary, the eccentricity of the active part of the rotor with respect to the stator is unavoidable in big generators of power plants, because they operate above their first critical speed and are supported by oil-film bearings. In the first part of the paper, a method aimed to calculate the UMP force is described. This model is more general than those available in literature, which are limited to circular orbits. The model is based on the actual position of the rotor inside the stator, therefore on the actual air-gap distribution, regardless of the orbit type. The closed form of the nonlinear UMP force components is presented. In the second part, the experimental validation of the proposed model is presented. The dynamical behaviour in the time domain of a steam turbo-generator of a power plant is considered and it is shown that the model is able to reproduce the dynamical effects due to the excitation of the magnetic field in the generator.

[The myxoedema coma exists, we met it].

PubMed

Fritsch, N; Tran-Van, D; Dardare, E; Gentile, A; Deroudilhe, G; Fontaine, B

2007-09-01

The myxoedema coma corresponds to the ultimate evolution of a hypothyroidism and is characterized by a major deficit in thyroid hormones responsible for a collapse of the metabolism. The preventive and curative treatment is based on the administration of thyroid hormones, whose benefits are opposed to the cardiovascular risks related to an iatrogenic hyperthyroidism for patients often old with cardiopathy. We report the case of a 92-year-old patient with unbalanced hypothyroidism and chronic cardiac deficiency, who presented a myxoedema coma in the postoperative period of an urgent digestive surgery. This observation illustrates the difficulties in treating patients with unbalanced hypothyroidism following emergency surgery, in the absence of consensus on the type and the amounts of thyroid hormones substitution.

Cyclopia and cebocephaly in two newborn infants with unbalanced segregation of a familial translocation rcp (1;7)(q32;q34).

PubMed

Schinzel, A

1984-05-01

This is a report of a family with a balanced reciprocal translocation, rcp (1;7)(q32;q34). Among pregnancies from translocation carriers, there were several miscarriages, and two unbalanced offspring with dup(1q32----qter) and del (7q34----qter) who died perinatally. One was a male cyclops with additional brain malformations and hydronephrosis, the other was a cebocephalic female with multiple additional malformations of heart, kidneys, and skeleton. In both pregnancies, the brain and renal anomalies were detected prenatally by ultrasound, in the cyclops during the 32nd and in the cebocephalic fetus during the 28th week of gestation.

Illusion optics in chaotic light

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Suheng; Gan Shu; Xiong Jun

2010-08-15

The time-reversal process provides the possibility to counteract the time evolution of a physical system. Recent research has shown that such a process can occur in the first-order field correlation of chaotic light and result in the spatial interference and phase-reversal diffraction in an unbalanced interferometer. Here we report experimental investigations on the invisibility cloak and illusion phenomena in chaotic light. In an unbalanced interferometer illuminated by thermal light, we have observed the cloak effect and the optical transformation of one object into another object. The experimental results can be understood by the phase-reversal diffraction, and they demonstrate the theoreticalmore » proposal of similar effects in complementary media.« less

Dewetting kinetics of metallic liquid films: Competition between unbalanced Young's force and dissolutive reaction

NASA Astrophysics Data System (ADS)

Lu, Gui; Lin, Lin; Hui, Sheng; Wang, Shuo-Lin; Wang, Xiao-Dong; Lee, Duu-Jong

2017-11-01

Dewetting kinetics of Al and NiAl metallic liquid films on NiAl (1 0 0) substrates was studied using molecular dynamics simulations. A new dewetting-spreading transitional behavior was observed for high temperature dewetting. The dewetting-spreading transition comes from the competition between unbalanced Young's force and dissolutive reaction. Without dissolutive reaction, liquid films keep dewetting, but immediately turn into spreading when the dissolutive reaction involved. The dissolutive reaction depends on the initial Ni atom contents rather than the contact areas of dewetting films. The far-away-from saturated Ni content is the main mechanism which accelerates the wetting and reverses the dewetting process at high temperatures.

Fault detection and diagnosis of induction motors using motor current signature analysis and a hybrid FMM-CART model.

PubMed

Seera, Manjeevan; Lim, Chee Peng; Ishak, Dahaman; Singh, Harapajan

2012-01-01

In this paper, a novel approach to detect and classify comprehensive fault conditions of induction motors using a hybrid fuzzy min-max (FMM) neural network and classification and regression tree (CART) is proposed. The hybrid model, known as FMM-CART, exploits the advantages of both FMM and CART for undertaking data classification and rule extraction problems. A series of real experiments is conducted, whereby the motor current signature analysis method is applied to form a database comprising stator current signatures under different motor conditions. The signal harmonics from the power spectral density are extracted as discriminative input features for fault detection and classification with FMM-CART. A comprehensive list of induction motor fault conditions, viz., broken rotor bars, unbalanced voltages, stator winding faults, and eccentricity problems, has been successfully classified using FMM-CART with good accuracy rates. The results are comparable, if not better, than those reported in the literature. Useful explanatory rules in the form of a decision tree are also elicited from FMM-CART to analyze and understand different fault conditions of induction motors.

What could the entire cornstover contribute to the enhancement of waste activated sludge acidification? Performance assessment and microbial community analysis.

PubMed

Zhou, Aijuan; Zhang, Jiaguang; Wen, Kaili; Liu, Zhihong; Wang, Guoying; Liu, Wenzong; Wang, Aijie; Yue, Xiuping

2016-01-01

Volatile fatty acids (VFAs) production from waste activated sludge (WAS) digestion is constrained by unbalanced nutrient composition (low carbon-to-nitrogen ratio). Characteristics conditioning by extra carbon sources, normally in the mixture of raw solid, has been reported to be an efficient approach to enhance WAS acidification. However, little attention has been paid to the contributions of other adjustment forms. Moreover, the corresponding ecological estimation has not been investigated yet. In this study, the feasibility of corn stover (CS) conditioning with three adjustment forms [pretreated straw (S), hydrolysate (H) and hydrolysate + straw (HS)] in improving VFAs production from WAS was demonstrated. It was observed that the highest VFAs yield was achieved in H co-digesting test (574 mg COD/g VSS), while it was only 392 mg COD/g VSS for WAS digesting alone. VFAs composition was strongly adjustment form-dependent, as more acetic (HAc) and propionic (HPr) acids were generated in CS_HS and S, respectively. High-throughput sequencing analysis illustrated that acid (especially HAc)-producing characteristic genera ( Bacteroides , Proteiniclasticum and Fluviicola ) and HPr-producing characteristic genera ( Mangroviflexu s and Paludibacter ) were detected by CS_HS and S conditioning, respectively. Corn stover conditioning greatly upgraded the WAS acidification performance, especially for the CS_H adjustment form, and the VFAs yield gained was considerably larger than that previously reported. CS adjustment forms played an important role in structuring the innate microbial community in WAS. Canonical correlation analysis illustrated that characteristic genera, with better hydrolysis and acidification abilities, could be enriched by the feedstocks with certain content of cellulose, hemicellulose or their saccharification hydrolysates. Moreover, ecological estimation revealed that, as far as the entire CS (including S and H) per acre was concerned, the capacity of WAS treatment would reach that produced in a one million mts capacity wastewater treatment plants (WWTPs) per day. These findings may have crucial implications for the operation of WWTPs.

Classification of highly unbalanced CYP450 data of drugs using cost sensitive machine learning techniques.

PubMed

Eitrich, T; Kless, A; Druska, C; Meyer, W; Grotendorst, J

2007-01-01

In this paper, we study the classifications of unbalanced data sets of drugs. As an example we chose a data set of 2D6 inhibitors of cytochrome P450. The human cytochrome P450 2D6 isoform plays a key role in the metabolism of many drugs in the preclinical drug discovery process. We have collected a data set from annotated public data and calculated physicochemical properties with chemoinformatics methods. On top of this data, we have built classifiers based on machine learning methods. Data sets with different class distributions lead to the effect that conventional machine learning methods are biased toward the larger class. To overcome this problem and to obtain sensitive but also accurate classifiers we combine machine learning and feature selection methods with techniques addressing the problem of unbalanced classification, such as oversampling and threshold moving. We have used our own implementation of a support vector machine algorithm as well as the maximum entropy method. Our feature selection is based on the unsupervised McCabe method. The classification results from our test set are compared structurally with compounds from the training set. We show that the applied algorithms enable the effective high throughput in silico classification of potential drug candidates.

A set of 14 DIP-SNP markers to detect unbalanced DNA mixtures.

PubMed

Liu, Zhizhen; Liu, Jinding; Wang, Jiaqi; Chen, Deqing; Liu, Zidong; Shi, Jie; Li, Zeqin; Li, Wenyan; Zhang, Gengqian; Du, Bing

2018-03-04

Unbalanced DNA mixture is still a difficult problem for forensic practice. DIP-STRs are useful markers for detection of minor DNA but they are not widespread in the human genome and having long amplicons. In this study, we proposed a novel type of genetic marker, termed DIP-SNP. DIP-SNP refers to the combination of INDEL and SNP in less than 300bp length of human genome. The multiplex PCR and SNaPshot assay were established for 14 DIP-SNP markers in a Chinese Han population from Shanxi, China. This novel compound marker allows detection of the minor DNA contributor with sensitivity from 1:50 to 1:1000 in a DNA mixture of any gender with 1 ng-10 ng DNA template. Most of the DIP-SNP markers had a relatively high probability of informative alleles with an average I value of 0.33. In all, we proposed DIP-SNP as a novel kind of genetic marker for detection of minor contributor from unbalanced DNA mixture and established the detection method by associating the multiplex PCR and SNaPshot assay. DIP-SNP polymorphisms are promising markers for forensic or clinical mixture examination because they are shorter, widespread and higher sensitive. Copyright © 2018 Elsevier Inc. All rights reserved.

Effect of Diet and Exercise on the Peripheral Immune System in Young Balb/c Mice

PubMed Central

Martínez-Carrillo, B. E.; Jarillo-Luna, R. A.; Campos-Rodríguez, R.; Valdés-Ramos, R.; Rivera-Aguilar, V.

2015-01-01

Although diet and exercise clearly have an influence on immune function, studies are scarce on the effect caused by exercise and the consumption of a carbohydrate-rich or fat-rich diet on the peripheral immune system. The aim of the present study was to evaluate the effect of exercise and the two aforementioned unbalanced diets on young Balb/c mice, especially in relation to BMI, the level of glucose, and the percentage of lymphocyte subpopulations in peripheral blood. The changes found were then related to the synthesis of leptin and adiponectin as well as the production of oxidative stress. The increase in BMI found with the carbohydrate-rich and fat-rich diets showed correlation with the levels of leptin and adiponectin. An increase in leptin and a decrease in adiponectin directly correlated with an increase in total lymphocytes and CD4+ cells and with a decrease in B cells. The increase in leptin also correlated with an increase in CD8+ cells. Glycemia and oxidative stress increased with the two unbalanced diets, negatively affecting the proliferation of total lymphocytes and the percentage of B cells, apparently by causing alterations in proteins through carbonylation. These alterations caused by an unbalanced diet were not modified by moderate exercise. PMID:26634209

Unbalanced Activation of Glutathione Metabolic Pathways Suggests Potential Involvement in Plant Defense against the Gall Midge Mayetiola destructor in Wheat

PubMed Central

Liu, Xuming; Zhang, Shize; Whitworth, R. Jeff; Stuart, Jeffrey J.; Chen, Ming-Shun

2015-01-01

Glutathione, γ-glutamylcysteinylglycine, exists abundantly in nearly all organisms. Glutathione participates in various physiological processes involved in redox reactions by serving as an electron donor/acceptor. We found that the abundance of total glutathione increased up to 60% in resistant wheat plants within 72 hours following attack by the gall midge Mayetiola destructor, the Hessian fly. The increase in total glutathione abundance, however, is coupled with an unbalanced activation of glutathione metabolic pathways. The activity and transcript abundance of glutathione peroxidases, which convert reduced glutathione (GSH) to oxidized glutathione (GSSG), increased in infested resistant plants. However, the enzymatic activity and transcript abundance of glutathione reductases, which convert GSSG back to GSH, did not change. This unbalanced regulation of the glutathione oxidation/reduction cycle indicates the existence of an alternative pathway to regenerate GSH from GSSG to maintain a stable GSSG/GSH ratio. Our data suggest the possibility that GSSG is transported from cytosol to apoplast to serve as an oxidant for class III peroxidases to generate reactive oxygen species for plant defense against Hessian fly larvae. Our results provide a foundation for elucidating the molecular processes involved in glutathione-mediated plant resistance to Hessian fly and potentially other pests as well. PMID:25627558

Proposal to use vibration analysis steering components and car body to monitor, for example, the state of unbalance wheel

NASA Astrophysics Data System (ADS)

Janczur, R.

2016-09-01

The results of road tests of car VW Passat equipped with tires of size 195/65 R15, on the influence of the unbalancing front wheel on vibration of the parts of steering system, steering wheel and the body of the vehicle have been presented in this paper. Unbalances wheels made using weights of different masses, placed close to the outer edge of the steel rim and checked on the machine Hunter GSP 9700 for balancing wheels. The recorded waveforms vibration steering components and car body, at different constant driving speeds, subjected to spectral analysis to determine the possibility of isolating vibration caused by unbalanced wheel in various states and coming from good quality asphalt road surface. The results were discussed in terms of the possibility of identifying the state of unbalancing wheels and possible changes in radial stiffness of the tire vibration transmitted through the system driving wheel on the steering wheel. Vibration analysis steering components and car body, also in the longitudinal direction, including information from the CAN bus of the state of motion of the car, can be used to monitor the development of the state of unbalance wheel, tire damage or errors shape of brake discs or brake drums, causing pulsations braking forces.

Classification of high-grade spondylolistheses based on pelvic version and spine balance: possible rationale for reduction.

PubMed

Hresko, Michael T; Labelle, Hubert; Roussouly, Pierre; Berthonnaud, Eric

2007-09-15

Retrospective review of a radiographic database of high-grade spondylolisthesis patients in comparison with asymptomatic controls. To analyze the sagittal spinopelvic alignment in high-grade spondylolisthesis patients and identify subgroups that may require reduction to restore sagittal balance. High-grade spondylolisthesis is associated with an abnormally high pelvic incidence (PI); however, the spatial orientation of the pelvis, determined by sacral slope (SS) and pelvic tilt (PT), is not known. We hypothesized that sagittal spinal alignment would vary with the pelvic orientation. Digitized sagittal radiographs of 133 high-grade spondylolisthesis patients (mean age, 17 years) were measured to determined sagittal alignment. K-means cluster analysis identified 2 groups based on the PT and SS, which were compared by paired t test. Comparisons were made to asymptomatic controls matched for PI. High-grade spondylolisthesis patients had a mean PI of 78.9 degrees +/- 12.1 degrees . Cluster analysis identified a retroverted, unbalanced pelvis group with high PT (36.5 degrees +/- 8.0 degrees )/low SS (40.3 degrees +/- 9.0 degrees ) and a balanced pelvic group with low PT (mean 21.3 degrees +/- 8.2 degrees )/high SS (59.9 degrees +/- 11.2 degrees ). The retroverted pelvis group had significantly greater L5 incidence and lumbosacral angle with less thoracic kyphosis than the balanced pelvic group. A total of 83% of controls had a "balanced pelvis" based on the categorization by SS and PT. Analysis of sagittal alignment of high-grade spondylolisthesis patients revealed distinct groups termed "balanced" and "unbalanced" pelvis. The PT and SS were similar in controls and balanced pelvis patients. Unbalanced pelvis patients had a sagittal spinal alignment that differed from the balanced pelvis and control groups. Treatment strategies for high-grade spondylolisthesis should reflect the different mechanical strain on the spinopelvic junction in each group; reduction techniques might be considered in patients with an unbalanced pelvis high-grade spondylolisthesis.

Cluster randomised crossover trials with binary data and unbalanced cluster sizes: application to studies of near-universal interventions in intensive care.

PubMed

Forbes, Andrew B; Akram, Muhammad; Pilcher, David; Cooper, Jamie; Bellomo, Rinaldo

2015-02-01

Cluster randomised crossover trials have been utilised in recent years in the health and social sciences. Methods for analysis have been proposed; however, for binary outcomes, these have received little assessment of their appropriateness. In addition, methods for determination of sample size are currently limited to balanced cluster sizes both between clusters and between periods within clusters. This article aims to extend this work to unbalanced situations and to evaluate the properties of a variety of methods for analysis of binary data, with a particular focus on the setting of potential trials of near-universal interventions in intensive care to reduce in-hospital mortality. We derive a formula for sample size estimation for unbalanced cluster sizes, and apply it to the intensive care setting to demonstrate the utility of the cluster crossover design. We conduct a numerical simulation of the design in the intensive care setting and for more general configurations, and we assess the performance of three cluster summary estimators and an individual-data estimator based on binomial-identity-link regression. For settings similar to the intensive care scenario involving large cluster sizes and small intra-cluster correlations, the sample size formulae developed and analysis methods investigated are found to be appropriate, with the unweighted cluster summary method performing well relative to the more optimal but more complex inverse-variance weighted method. More generally, we find that the unweighted and cluster-size-weighted summary methods perform well, with the relative efficiency of each largely determined systematically from the study design parameters. Performance of individual-data regression is adequate with small cluster sizes but becomes inefficient for large, unbalanced cluster sizes. When outcome prevalences are 6% or less and the within-cluster-within-period correlation is 0.05 or larger, all methods display sub-nominal confidence interval coverage, with the less prevalent the outcome the worse the coverage. As with all simulation studies, conclusions are limited to the configurations studied. We confined attention to detecting intervention effects on an absolute risk scale using marginal models and did not explore properties of binary random effects models. Cluster crossover designs with binary outcomes can be analysed using simple cluster summary methods, and sample size in unbalanced cluster size settings can be determined using relatively straightforward formulae. However, caution needs to be applied in situations with low prevalence outcomes and moderate to high intra-cluster correlations. © The Author(s) 2014.

Enabling the High Level Synthesis of Data Analytics Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minutoli, Marco; Castellana, Vito G.; Tumeo, Antonino

Conventional High Level Synthesis (HLS) tools mainly tar- get compute intensive kernels typical of digital signal pro- cessing applications. We are developing techniques and ar- chitectural templates to enable HLS of data analytics appli- cations. These applications are memory intensive, present fine-grained, unpredictable data accesses, and irregular, dy- namic task parallelism. We discuss an architectural tem- plate based around a distributed controller to efficiently ex- ploit thread level parallelism. We present a memory in- terface that supports parallel memory subsystems and en- ables implementing atomic memory operations. We intro- duce a dynamic task scheduling approach to efficiently ex- ecute heavilymore » unbalanced workload. The templates are val- idated by synthesizing queries from the Lehigh University Benchmark (LUBM), a well know SPARQL benchmark.« less

Research on the fiber Bragg grating sensor for the shock stress measurement

PubMed Central

Deng, Xiangyang; Chen, Guanghua; Peng, Qixian; Li, Zeren; Meng, Jianhua; Liu, Jun

2011-01-01

A fiber Bragg grating (FBG) sensor with an unbalanced Mach-Zehnder fiber interferometer for the shock stress measurement is proposed and demonstrated. An analysis relationship between the shock stress and the central reflection wavelength shift of the FBG is firstly derived. In this sensor, the optical path difference of the unbalanced Mach-Zehnder fiber interferometer is ∼3.1 mm and the length of the FBG is 2 mm. An arctangent function reduction method, which can avoid sine function's insensitive zone where the shock stress measurement has a reduced accuracy, is presented. A shock stress measurement of water driven by one stage gun (up to 1.4 GPa), with good theoretical accuracy (∼10%), is launched. PMID:22047282

INITIATORS AND TRIGGERING CONDITIONS FOR ADAPTIVE AUTOMATION IN ADVANCED SMALL MODULAR REACTORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katya L Le Blanc; Johanna h Oxstrand

It is anticipated that Advanced Small Modular Reactors (AdvSMRs) will employ high degrees of automation. High levels of automation can enhance system performance, but often at the cost of reduced human performance. Automation can lead to human out-of the loop issues, unbalanced workload, complacency, and other problems if it is not designed properly. Researchers have proposed adaptive automation (defined as dynamic or flexible allocation of functions) as a way to get the benefits of higher levels of automation without the human performance costs. Adaptive automation has the potential to balance operator workload and enhance operator situation awareness by allocating functionsmore » to the operators in a way that is sensitive to overall workload and capabilities at the time of operation. However, there still a number of questions regarding how to effectively design adaptive automation to achieve that potential. One of those questions is related to how to initiate (or trigger) a shift in automation in order to provide maximal sensitivity to operator needs without introducing undesirable consequences (such as unpredictable mode changes). Several triggering mechanisms for shifts in adaptive automation have been proposed including: operator initiated, critical events, performance-based, physiological measurement, model-based, and hybrid methods. As part of a larger project to develop design guidance for human-automation collaboration in AdvSMRs, researchers at Idaho National Laboratory have investigated the effectiveness and applicability of each of these triggering mechanisms in the context of AdvSMR. Researchers reviewed the empirical literature on adaptive automation and assessed each triggering mechanism based on the human-system performance consequences of employing that mechanism. Researchers also assessed the practicality and feasibility of using the mechanism in the context of an AdvSMR control room. Results indicate that there are tradeoffs associated with each mechanism, but that some are more applicable to the AdvSMR domain. The two mechanisms that consistently improve performance in laboratory studies are operator initiated adaptive automation based on hierarchical task delegation and the Electroencephalogram(EEG) –based measure of engagement. Current EEG methods are intrusive and require intensive analysis; therefore it is not recommended for an AdvSMR control rooms at this time. Researchers also discuss limitations in the existing empirical literature and make recommendations for further research.« less

Total Transfer Capability Assessment Incorporating Corrective Controls for Transient Stability using TSCOPF

NASA Astrophysics Data System (ADS)

Hakim, Lukmanul; Kubokawa, Junji; Yorino, Naoto; Zoka, Yoshifumi; Sasaki, Yutaka

Advancements have been made towards inclusion of both static and dynamic security into transfer capability calculation. However, to the authors' knowledge, work on considering corrective controls into the calculation has not been reported yet. Therefore, we propose a Total Transfer Capability (TTC) assessment considering transient stability corrective controls. The method is based on the Newton interior point method for nonlinear programming and transfer capability is approached as a maximization of power transfer with both static and transient stability constraints are incorporated into our Transient Stability Constrained Optimal Power Flow (TSCOPF) formulation. An interconnected power system is simulated to be subjected to a severe unbalanced 3-phase 4-line to ground fault and following the fault, generator and load are shed in a pre-defined sequence to mimic actual corrective controls. In a deregulated electricity market, both generator companies and large load customers are encouraged to actively participate in maintaining power system stability as corrective controls upon agreement of compensation for being shed following a disturbance. Implementation of this proposal on the actual power system operation should be carried out through combining it with the existing transient stabilization controller system. Utilization of these corrective controls results in increasing TTC as suggested in our numerical simulation. As Lagrange multipliers can also describe sensitivity of both inequality and equality constraints to the objective function, then selection of which generator or load to be shed can be carried out on the basis of values of Lagrange multipliers of its respective generator's rotor angle stability and active power balance equation. Hence, the proposal in this paper can be utilized by system operator to assess the maximum TTC for specific loads and network conditions.

The case from animal studies for balanced binocular treatment strategies for human amblyopia.

PubMed

Mitchell, Donald E; Duffy, Kevin R

2014-03-01

Although amblyopia typically manifests itself as a monocular condition, its origin has long been linked to unbalanced neural signals from the two eyes during early postnatal development, a view confirmed by studies conducted on animal models in the last 50 years. Despite recognition of its binocular origin, treatment of amblyopia continues to be dominated by a period of patching of the non-amblyopic eye that necessarily hinders binocular co-operation. This review summarizes evidence from three lines of investigation conducted on an animal model of deprivation amblyopia to support the thesis that treatment of amblyopia should instead focus upon procedures that promote and enhance binocular co-operation. First, experiments with mixed daily visual experience in which episodes of abnormal visual input were pitted against normal binocular exposure revealed that short exposures of the latter offset much longer periods of abnormal input to allow normal development of visual acuity in both eyes. Second, experiments on the use of part-time patching revealed that purposeful introduction of episodes of binocular vision each day could be very beneficial. Periods of binocular exposure that represented 30-50% of the daily visual exposure included with daily occlusion of the non-amblyopic could allow recovery of normal vision in the amblyopic eye. Third, very recent experiments demonstrate that a short 10 day period of total darkness can promote very fast and complete recovery of visual acuity in the amblyopic eye of kittens and may represent an example of a class of artificial environments that have similar beneficial effects. Finally, an approach is described to allow timing of events in kitten and human visual system development to be scaled to optimize the ages for therapeutic interventions. © 2014 The Authors Ophthalmic & Physiological Optics © 2014 The College of Optometrists.

Dynamic Performance of a Back-to-Back HVDC Station Based on Voltage Source Converters

NASA Astrophysics Data System (ADS)

Khatir, Mohamed; Zidi, Sid-Ahmed; Hadjeri, Samir; Fellah, Mohammed-Karim

2010-01-01

The recent developments in semiconductors and control equipment have made the voltage source converter based high voltage direct current (VSC-HVDC) feasible. This new DC transmission is known as "HVDC Light or "HVDC Plus by leading vendors. Due to the use of VSC technology and pulse width modulation (PWM) the VSC-HVDC has a number of potential advantages as compared with classic HVDC. In this paper, the scenario of back-to-back VSC-HVDC link connecting two adjacent asynchronous AC networks is studied. Control strategy is implemented and its dynamic performances during disturbances are investigated in MATLAB/Simulink program. The simulation results have shown good performance of the proposed system under balanced and unbalanced fault conditions.

Transplant professionals' proposals for the implementation of an altruistic unbalanced paired kidney exchange program.

PubMed

Durand, Céline; Duplantie, Andrée; Fortin, Marie-Chantal

2014-10-15

Kidney recipients in the O blood group are at a disadvantage in kidney exchange programs (KEPs) because they can only receive an organ from O blood group donors. A way to remedy this unfair situation is through altruistic unbalanced paired kidney exchange (AUPKE) where a compatible pair (CP) consisting of an O donor and a non-O recipient is invited to participate in a KEP. There is no established AUPKE program in Canada. The aim of this study was to gather transplant professionals' views on the conditions necessary for the implementation of an AUPKE program. Nineteen Canadian transplant professionals took part in semistructured interviews. The content of these interviews was analyzed using a qualitative data analysis method. Respondents' recommendations focused on the following: (i) the logistics of AUPKE (e.g., not delaying the transplantation for the CP, retrieving organs locally, providing a good quality organ to the CP, and maintaining anonymity); (ii) the transplantation teams (e.g., establishing a consensus among members and ensuring sufficient resources); (iii) information provided to CPs; and (iv) research (e.g., looking into all transplant options for O recipients, studying all potential impacts of KEPs and AUPKE). The respondents in our study made the following recommendations for the implementation of an AUPKE program: (i) CPs should not be disadvantaged, (ii) measures should be taken to ensure that all transplant team members agree to participate and that there are sufficient resources for implementation, (iii) comprehensive information should be provided to the CP, and (iv) further research is needed on AUPKE.

ISS SGANT Group Level Offloading Test Mechanism

NASA Technical Reports Server (NTRS)

Zhang, Xi-Lin

2002-01-01

The International Space Station (ISS) Space-to-Ground Antenna (SGANT) is used for ISS communication with earth through the Tracking and Data Relay Satellite (TDRSS). Due to the different speeds of travel between earth, ISS and TDRSS, a steerable SGANT was required on the ISS. The mechanical design of SGANT is an unbalanced mechanism with insufficient strength and driving torque to support and drive itself in a 1G environment. For ground testing, a specially designed offloading mechanism is required. Basically, the test mechanism must offload the SGANT in a two-axis operation, allowing the SGANT to move within a specific range, speed and acceleration; therefore the SGANT can move from elevation 0 to 90 deg and be tested at both the 0 and 90 deg positions. The load introduced by the test equipment should be less than 10.17 N-m (7.5 ft-lbf). The on-ground group level tracking test is quite challenging due to the unbalanced antenna mechanical design and tough specification requirements. This paper describes the detailed design, fabrication, and calibration of the test mechanism, and how the above requirements are met. The overall antenna is simplified to a mass model in order to facilitate the offloading mechanism design and analysis. An actual SGANT mass dummy was made to calibrate the system. This paper brings together the theoretical analysis and the industrial experience that were relied upon to meet the above-mentioned requirements for the ground test. The lessons learned during the calibration phase are extremely important for future double or multiple offloading system designs. The ISS SGANT QM and FM units passed their ground test and the SGANT/Boom fit check successfully, and the Flight Model (FM) was delivered to SSPF in April 1998. It is now installed on ISS and functioning well.

Communication imperialism and dependency: a conceptual clarification.

PubMed

Lee, P S

1988-01-01

Communications imperialism has to do with the domination of a country's media activities by another. The ownership, structure, distribution or content of the media in 1 country are affected by pressures from media interests of another country or group out of proportion with those of that country. To determine if this is happening we should consider the country's policies, the private sector;s efforts to export communications elements, and actions of the dominant country against the dominated. The 4 aspects of international media in this situation are television program exportation, foreign ownership and control of media distribution, the infringement of capital opinions on other societies, and the transfer of commercialism and broadcasting norms. In addition to the software and hardware and the other forms of communication such as satellites, computers, and transportation of the mass media, there are the cultural effects on the developing countries. In the case of involuntary of voluntary dependency of the recipient country, the effect of the unbalanced international communication can be harmful or beneficial. Communication dependency may not be harmful to the culture of the recipient country. In determining the theory of unbalanced international communications 3 factors should be considered. There are: the role of the interacting countries, the nature of the dependency of the recipient country, and the beneficial or harmful effect of unbalanced communication pattern on that country.

Maternal consumption of a high-meat, low-carbohydrate diet in late pregnancy: relation to adult cortisol concentrations in the offspring.

PubMed

Herrick, Kirsten; Phillips, David I W; Haselden, Soraya; Shiell, Alistair W; Campbell-Brown, Mary; Godfrey, Keith M

2003-08-01

Recent studies have linked maternal consumption of an unbalanced high-protein, low-carbohydrate diet in late pregnancy with raised adult blood pressure in the offspring. Because high-protein diets stimulate the hypothalamic-pituitary-adrenal axis, we hypothesized that an unbalanced maternal diet might increase maternal cortisol levels, exposing the fetus to excess cortisol and programming lifelong hypersecretion of cortisol. We therefore measured fasting plasma cortisol concentrations in 251 subjects, 28-30 yr old, whose mothers had been advised to eat 0.45 kg of red meat daily during pregnancy and avoid carbohydrate-rich foods. Cortisol concentrations were higher in subjects with lower body mass index (P < 0.0001) and in those who reported recent vigorous activity (P = 0.03) and greater alcohol consumption (P = 0.004). Allowing for gender, current body mass index, activity, and alcohol consumption, cortisol concentrations increased 5.4% per portion of maternal meat/fish consumption per day (P = 0.03), decreased 3.3% per portion of maternal green vegetable consumption per week (P = 0.14), and were 12.2% higher in those born into manual social class families (P = 0.03). The specific advice given to mothers in this study precludes direct application to other populations, but the findings provide the first human evidence that an unbalanced maternal diet during late pregnancy may program lifelong hypercortisolemia in the offspring.

An unbalanced spectra classification method based on entropy

NASA Astrophysics Data System (ADS)

Liu, Zhong-bao; Zhao, Wen-juan

2017-05-01

How to solve the problem of distinguishing the minority spectra from the majority of the spectra is quite important in astronomy. In view of this, an unbalanced spectra classification method based on entropy (USCM) is proposed in this paper to deal with the unbalanced spectra classification problem. USCM greatly improves the performances of the traditional classifiers on distinguishing the minority spectra as it takes the data distribution into consideration in the process of classification. However, its time complexity is exponential with the training size, and therefore, it can only deal with the problem of small- and medium-scale classification. How to solve the large-scale classification problem is quite important to USCM. It can be easily obtained by mathematical computation that the dual form of USCM is equivalent to the minimum enclosing ball (MEB), and core vector machine (CVM) is introduced, USCM based on CVM is proposed to deal with the large-scale classification problem. Several comparative experiments on the 4 subclasses of K-type spectra, 3 subclasses of F-type spectra and 3 subclasses of G-type spectra from Sloan Digital Sky Survey (SDSS) verify USCM and USCM based on CVM perform better than kNN (k nearest neighbor) and SVM (support vector machine) in dealing with the problem of rare spectra mining respectively on the small- and medium-scale datasets and the large-scale datasets.

Looking for Solutions: Gender Differences in Relationship and Parenting Challenges Among Low-Income, Young Parents

PubMed Central

Albritton, Tashuna; Angley, Meghan; Grandelski, Valen; Hansen, Nathan; Kershaw, Trace

2015-01-01

The need for parenting and relationship strengthening programs is important among low-income minority parents where the burden of relational and parental stressors contributes to relationship dissolution. We examine these stressors among young parents. Data were collected from four focus groups (N = 35) with young parents. Data were audio-recorded and transcribed. Inductive coding was used to generate themes and codes, and analysis was completed using NVivo. Relationship and parenting challenges, values, and areas of need were the three major themes that emerged. Women's relationship challenges were family interference and unbalanced parenting, and men reported feeling disrespected and having limited finances. Common relationship challenges for women and men were family interference and unbalanced parenting. Both genders valued trust, communication, and honesty in relationships. Areas of need for women and men included: improving communication and understanding the impact of negative relationships on current relationships. Parenting challenges for women were unbalanced parenting, child safety, and feeling unprepared to parent; men reported limited finances. Both genders valued quality time with child to instill family morals. Areas of need for women and men included learning child discipline techniques and increasing knowledge about child development. Finally, women and men have relationship and parenting similarities and differences. Young parents are interested in learning how to improve relationships and co-parent to reduce relationship distress, which could reduce risk behaviors and improve child outcomes. PMID:24980026

Rotating mobile launcher

NASA Technical Reports Server (NTRS)

Gregory, T. J.

1977-01-01

Apparatus holds remotely piloted arm that accelerates until launching speed is reached. Then vehicle and counterweight at other end of arm are released simultaneously to avoid structural damage from unbalanced rotating forces.

Impact Capacity Reduction in Railway Prestressed Concrete Sleepers with Surface Abrasions

NASA Astrophysics Data System (ADS)

Ngamkhanong, Chayut; Li, Dan; Kaewunruen, Sakdirat

2017-10-01

Railway sleepers (also called ‘railroad tie’ in North America) embedded in ballasted railway tracks are a main part of railway track structures. Its important role is to transfer the loads evenly from the rails to a wider area of ballast bed and to secure rail gauge and enable safe passages of rolling stocks. By nature, railway infrastructure is nonlinear, evidenced by its behaviours, geometry and alignment, wheel-rail contact and operational parameters such as tractive efforts. Based on our critical review, the dynamic behaviour of railway sleepers has not been fully investigated, especially when the sleepers are deteriorated by excessive wears. In fact, the ballast angularity causes differential abrasions on the soffit or bottom surface of sleepers (especially at railseat zone). Furthermore, in sharp curves and rapid gradient change, longitudinal and lateral dynamics of rails increase the likelihood of railseat abrasions in concrete sleepers due to the unbalanced loading conditions. This paper presents a structural capacity of concrete sleepers under dynamic transient loading. The modified compression field theory for ultimate strength design of concrete sleepers under impact loading will be highlighted in this study. The influences of surface abrasions, including surface abrasion and soffit abrasion, on the dynamic behaviour of prestressed concrete sleepers, are firstly highlighted. The outcome of this study will improve the rail maintenance and inspection criteria in order to establish appropriate and sensible remote track condition monitoring network in practice. Moreover, this study will also improve the understanding of the fundamental dynamic behaviour of prestressed concrete sleepers with surface abrasions. The insight into these behaviours will not only improve safety and reliability of railway infrastructure but will enhance the structural safety of other concrete structures.

Rotating-unbalanced-mass Devices for Scanning Balloon-borne Experiments, Free-flying Spacecraft, and Space Shuttle/space Station Experiments

NASA Technical Reports Server (NTRS)

Polites, Michael E.

1990-01-01

A new method is presented for scanning balloon-borne experiments, free-flying spacecraft, and gimballed experiments mounted to the space shuttle or the space station. It uses rotating-unbalanced-mass (RUM) devices for generating circular, line, or raster scan patterns and an auxiliary control system for target acquisition, keeping the scan centered on the target, and producing complementary motion for raster scanning. It is ideal for applications where the only possible way to accomplish the required scan is to physically scan the entire experiment or spacecraft as in x ray and gamma ray experiments. In such cases, this new method should have advantages over prior methods in terms of either power, weight, cost, performance, stability, or a combination of these.

Properties of Diamond-Like Carbon Films Synthesized by Dual-Target Unbalanced Magnetron Sputtering

NASA Astrophysics Data System (ADS)

Liu, Cui; Li, Guo-Qing; Gou, Wei; Mu, Zong-Xin; Zhang, Cheng-Wu

2004-11-01

Smooth, dense and uniform diamond-like carbon films (DLC films) for industrial applications have successfully been prepared by dual-target unbalanced magnetron sputtering and the DLC characteristics of the films are confirmed by Raman spectra. It is found that the sputtering current of target plays an important role in the DLC film deposition. Deposition rate of 3.5 μm/h is obtained by using the sputtering current of 30 A. The friction coefficient of the films is 0.2-0.225 measured by using a pin-on-disc microtribometer. The structure of the films tends to have a growth of sp3 bonds content at high sputtering current. The compressive residual stress in the films increases with the increasing sputtering current of the target.

Large unbalanced credit scoring using Lasso-logistic regression ensemble.

PubMed

Wang, Hong; Xu, Qingsong; Zhou, Lifeng

2015-01-01

Recently, various ensemble learning methods with different base classifiers have been proposed for credit scoring problems. However, for various reasons, there has been little research using logistic regression as the base classifier. In this paper, given large unbalanced data, we consider the plausibility of ensemble learning using regularized logistic regression as the base classifier to deal with credit scoring problems. In this research, the data is first balanced and diversified by clustering and bagging algorithms. Then we apply a Lasso-logistic regression learning ensemble to evaluate the credit risks. We show that the proposed algorithm outperforms popular credit scoring models such as decision tree, Lasso-logistic regression and random forests in terms of AUC and F-measure. We also provide two importance measures for the proposed model to identify important variables in the data.

High-efficiency interaction-free measurement with an unbalanced Mach–Zehnder interferometer

NASA Astrophysics Data System (ADS)

Chao, Liu; Jinhong, Liu; Junxiang, Zhang; Shiyao, Zhu

2018-06-01

The presence of an object can be detected without the absorption of photons in an interaction-free measurement (IFM) system based on the Zeno effect in chained Mach–Zehnder interferometers (MZIs). In this paper, we propose a scheme with an unbalanced MZI to perform the transmission of two frequency components of input light simultaneously. The two components are separated at two output ports of the MZI, achieving a high probability of asserting the absence of the object. The two final outputs of the MZI can also be extended to perform special information processing via IFM. As a result, this proposal contributes to the improvement of efficiency in interaction-free measurements with a very small number of interferometers for potential practical implementations of quantum information technology.

Research on dynamic balancing simulation of rotary shaft based on ADAMS

NASA Astrophysics Data System (ADS)

Zheng, Weiqiang; Rui, Chengjie; Yang, Jie; Liu, Pingyi

2018-02-01

Due to the design and processing technology of rotary shaft, the mass center of it does not coincide with the rotating axis of the rotary shaft and there is an unbalanced mass. The unbalanced mass can have some disadvantages, such as the centrifugal force, the vibration and so on. Those disadvantages could reduce the accuracy and service life of the equipment.In this paper, the dynamic balance of the rotary shaft is analysed by the theory analysis combined with the dynamic simulation software. This method ensures that the rotary shaft meets the dynamic balancing requirements during the design stage. It effectively supports the structural design of the rotary shift, and provides a way of thinking and method for the design and development of the same type of products.

Signaling threat: how situational cues affect women in math, science, and engineering settings.

PubMed

Murphy, Mary C; Steele, Claude M; Gross, James J

2007-10-01

This study examined the cues hypothesis, which holds that situational cues, such as a setting's features and organization, can make potential targets vulnerable to social identity threat. Objective and subjective measures of identity threat were collected from male and female math, science, and engineering (MSE) majors who watched an MSE conference video depicting either an unbalanced ratio of men to women or a balanced ratio. Women who viewed the unbalanced video exhibited more cognitive and physiological vigilance, and reported a lower sense of belonging and less desire to participate in the conference, than did women who viewed the gender-balanced video. Men were unaffected by this situational cue. The implications for understanding vulnerability to social identity threat, particularly among women in MSE settings, are discussed.

Detection of stator winding faults in induction motors using three-phase current monitoring.

PubMed

Sharifi, Rasool; Ebrahimi, Mohammad

2011-01-01

The objective of this paper is to propose a new method for the detection of inter-turn short circuits in the stator windings of induction motors. In the previous reported methods, the supply voltage unbalance was the major difficulty, and this was solved mostly based on the sequence component impedance or current which are difficult to implement. Some other methods essentially are included in the offline methods. The proposed method is based on the motor current signature analysis and utilizes three phase current spectra to overcome the mentioned problem. Simulation results indicate that under healthy conditions, the rotor slot harmonics have the same magnitude in three phase currents, while under even 1 turn (0.3%) short circuit condition they differ from each other. Although the magnitude of these harmonics depends on the level of unbalanced voltage, they have the same magnitude in three phases in these conditions. Experiments performed under various load, fault, and supply voltage conditions validate the simulation results and demonstrate the effectiveness of the proposed technique. It is shown that the detection of resistive slight short circuits, without sensitivity to supply voltage unbalance is possible. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.

Preliminary results on passive eddy current damper technology for SSME turbomachinery

NASA Technical Reports Server (NTRS)

Cunningham, R. E.

1985-01-01

Some preliminary results have been obtained for the dynamic response of a rotor operating over a speed range of 800 to 10,000 rpm. Amplitude frequency plots show the lateral vibratory response of an unbalanced rotor with and without external damping. The mode of damping is by means of eddy currents generated with 4 c shaped permanent magnets installed at the lower bearing of a vertically oriented rotor. The lower ball bearing and its damper assembly are totally immersed in liquid nitrogen at a temperature of -197 deg C (-320 deg F). These preliminary results for a referenced or base line passive eddy current damper assembly show that the amplitude of synchronous vibration is reduced at the resonant frequency. Measured damping coefficients were calculated to phi = .086; this compares with a theoretically calculated value of phi = .079.

You Make the Diagnosis.

ERIC Educational Resources Information Center

Bradway, Heather A.

2001-01-01

Explains a laboratory activity in which students study the effects of balanced and unbalanced nutrition on individuals' health by examining simulated urine samples. Uses a journal writing approach and includes laboratory instructions. (YDS)

New Modulation Method and Control Strategies for Power Electronics Inverters

NASA Astrophysics Data System (ADS)

Aleenejad, Mohsen

The DC to AC power Converters (so-called Inverters) are widely used in industrial applications. The MLIs are becoming increasingly popular in industrial apparatus aimed at medium to high power conversion applications. In comparison to the conventional inverters, they feature superior characteristics such as lower total harmonic distortion (THD), higher efficiency, and lower switching voltage stress. Nevertheless, the superior characteristics come at the price of a more complex topology with an increased number of power electronic switches. The increased number of power electronics switches results in more complicated control strategies for the inverter. Moreover, as the number of power electronic switches increases, the chances of fault occurrence of the switches increases, and thus the inverter's reliability decreases. Due to the extreme monetary ramifications of the interruption of operation in commercial and industrial applications, high reliability for power inverters utilized in these sectors is critical. As a result, developing simple control strategies for normal and fault-tolerant operation of MLIs has always been an interesting topic for researchers in related areas. The purpose of this dissertation is to develop new control and fault-tolerant strategies for the multilevel power inverter. For the normal operation of the inverter, a new high switching frequency technique is developed. The proposed method extends the utilization of the dc link voltage while minimizing the dv/dt of the switches. In the event of a fault, the line voltages of the faulty inverters are unbalanced and cannot be applied to the 3-phase loads. For the faulty condition of the inverter, three novel fault-tolerant techniques are developed. The proposed fault-tolerant strategies generate balanced line voltages without bypassing any healthy and operative inverter element, makes better use of the inverter capacity and generates higher output voltage. These strategies exploit the advantages of the Selective Harmonic Elimination (SHE) and Space Vector Modulation (SVM) methods in conjunction with a slightly modified Fundamental Phase Shift Compensation (FPSC) technique to generate balanced voltages and manipulate voltage harmonics at the same time. The proposed strategies are applicable to several classes of MLIs with three or more voltage levels.

Perceptions of amputation before and after gunpowder.

PubMed

Kirkup, J

1995-12-01

Woodall's remark on limb amputation, in 1617, that "it is no small presumption to Dismember the Image of God", reflected lingering doubts attributable to widespread ancient beliefs or taboos which, at least during the early historic period, shunned elective amputations completely. Death was preferred to operative destruction of the body's integrity, even when societies were aware of traumatic, disease-induced and legal amputations, eventually to be accepted and managed rationally. Deep-rooted resistance to planned dismemberment became unbalanced by the malevolent wounds of gunshot missiles which contrasted vividly with cold steel and blunt injuries of earlier warfare. Massive soft tissue destruction, bone comminution and, above all, embedded missiles and clothing posed perplexing complications for both patients and surgeons, often causing gangrene and death. Finally despite resultant deformity, amputation was recognised as a means of preserving life. It is maintained the philosophical perception, believing it is better to live with three limbs than to die with four, gained acceptance due to the persuasive influence of gunpowder on battlefields and in battle-ships. Notwithstanding, until carbolised catgut ligatures were employed amputation remained a hazardous procedurep it persists as a repugnant operation of last resort.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cotton, W. D.; Mason, B. S.; Dicker, S. R.

This paper presents new observations of the active galactic nuclei M87 and Hydra A at 90 GHz made with the MUSTANG array on the Green Bank Telescope at 8.''5 resolution. A spectral analysis is performed combining this new data and archival VLA{sup 7}The VLA is operated by the National Radio Astronomy Observatory, which is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc. data on these objects at longer wavelengths. This analysis can detect variations in spectral index and curvature expected from energy losses in the radiating particles. M87 shows only weak evidence formore » steepening of the spectrum along the jet suggesting either re-acceleration of the relativistic particles in the jet or insufficient losses to affect the spectrum at 90 GHz. The jets in Hydra A show strong steepening as they move from the nucleus suggesting unbalanced losses of the higher energy relativistic particles. The difference between these two sources may be accounted for by the lengths over which the jets are observable, 2 kpc for M87 and 45 kpc for Hydra A.« less

Malnutrition

MedlinePlus

... fats, vitamins, and minerals - you may suffer from malnutrition. Causes of malnutrition include: Lack of specific nutrients in your diet. ... the lack of one vitamin can lead to malnutrition. An unbalanced diet Certain medical problems, such as ...

Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach.

PubMed

Cheng, Feixiong; Liu, Chuang; Shen, Bairong; Zhao, Zhongming

2016-08-26

Cancer is increasingly recognized as a cellular system phenomenon that is attributed to the accumulation of genetic or epigenetic alterations leading to the perturbation of the molecular network architecture. Elucidation of network properties that can characterize tumor initiation and progression, or pinpoint the molecular targets related to the drug sensitivity or resistance, is therefore of critical importance for providing systems-level insights into tumorigenesis and clinical outcome in the molecularly targeted cancer therapy. In this study, we developed a network-based framework to quantitatively examine cellular network heterogeneity and modularity in cancer. Specifically, we constructed gene co-expressed protein interaction networks derived from large-scale RNA-Seq data across 8 cancer types generated in The Cancer Genome Atlas (TCGA) project. We performed gene network entropy and balanced versus unbalanced motif analysis to investigate cellular network heterogeneity and modularity in tumor versus normal tissues, different stages of progression, and drug resistant versus sensitive cancer cell lines. We found that tumorigenesis could be characterized by a significant increase of gene network entropy in all of the 8 cancer types. The ratio of the balanced motifs in normal tissues is higher than that of tumors, while the ratio of unbalanced motifs in tumors is higher than that of normal tissues in all of the 8 cancer types. Furthermore, we showed that network entropy could be used to characterize tumor progression and anticancer drug responses. For example, we found that kinase inhibitor resistant cancer cell lines had higher entropy compared to that of sensitive cell lines using the integrative analysis of microarray gene expression and drug pharmacological data collected from the Genomics of Drug Sensitivity in Cancer database. In addition, we provided potential network-level evidence that smoking might increase cancer cellular network heterogeneity and further contribute to tyrosine kinase inhibitor (e.g., gefitinib) resistance. In summary, we demonstrated that network properties such as network entropy and unbalanced motifs associated with tumor initiation, progression, and anticancer drug responses, suggesting new potential network-based prognostic and predictive measure in cancer.

The Theory and Fundamentals of Bioimpedance Analysis in Clinical Status Monitoring and Diagnosis of Diseases

PubMed Central

Khalil, Sami F.; Mohktar, Mas S.; Ibrahim, Fatimah

2014-01-01

Bioimpedance analysis is a noninvasive, low cost and a commonly used approach for body composition measurements and assessment of clinical condition. There are a variety of methods applied for interpretation of measured bioimpedance data and a wide range of utilizations of bioimpedance in body composition estimation and evaluation of clinical status. This paper reviews the main concepts of bioimpedance measurement techniques including the frequency based, the allocation based, bioimpedance vector analysis and the real time bioimpedance analysis systems. Commonly used prediction equations for body composition assessment and influence of anthropometric measurements, gender, ethnic groups, postures, measurements protocols and electrode artifacts in estimated values are also discussed. In addition, this paper also contributes to the deliberations of bioimpedance analysis assessment of abnormal loss in lean body mass and unbalanced shift in body fluids and to the summary of diagnostic usage in different kinds of conditions such as cardiac, pulmonary, renal, and neural and infection diseases. PMID:24949644

Cloistered Baryogenesis

NASA Astrophysics Data System (ADS)

Fong, Chee Sheng

2015-10-01

The cosmic matter-antimatter asymmetry can be generated through baryon number conserving decays of heavy particles that produce asymmetries in the two final states that carry equal and opposite baryon number in which one of them couples directly or indirectly to electroweak sphalerons. The final state that participates in electroweak sphalerons will have its baryon asymmetry partly reprocessed to a lepton asymmetry while the other remains chemically decoupled from the thermal bath or cloistered with its baryon content frozen. The key condition for this mechanism to work is for the decoupled particles to remain cloistered until after electroweak sphalerons freeze out and then the subsequent decays of the particles will inject an unbalanced baryon asymmetry in the thermal bath giving rise to a net nonzero baryon asymmetry. Such a condition implies weakly coupled particles and if produced in a collider could give signatures of long-lived (on a collider timescale) particles. We discuss such a scenario with a type-I seesaw model extended by a new colored scalar.

Date seed characterisation, substrate extraction and process modelling for the production of polyhydroxybutyrate by Cupriavidus necator.

PubMed

Yousuf, R G; Winterburn, J B

2016-12-01

Poly-3-hydroxybutrate (PHB) is a biodegradable polymer synthesised via bacterial fermentation as a means of storing carbon and energy under unbalanced growth conditions. The production cost of petroleum-based plastics is currently lower than that for biopolymers, and the carbon source is the most significant contributor to biopolymer production cost. A feasibility study to assess the suitability of using a date seed derived media as an alternative for PHB production under various stress conditions was investigated. Results include fructose extraction from date seeds and a mass transfer model to describe the process, demonstrating that the high nutrient content of date seeds makes them a promising raw material for microbial growth and that a meaningful amount of PHB can be produced without supplementation. Maximum dry cell weight and PHB concentrations were 6.3g/l and 4.6g/l respectively, giving a PHB content of 73%, when an initial fructose concentration of 10.8g/l was used. Copyright © 2016 Elsevier Ltd. All rights reserved.

Measurement Of Hydrogen Capacities And Stability In Thin Films Of AlH Deposited By Magnetron Sputtering

NASA Astrophysics Data System (ADS)

Dissanayake, A.; AlFaify, S.; Garratt, E.; Nandasiri, M. I.; Taibu, R.; Tecos, G.; Hamdan, N. M.; Kayani, A.

2011-06-01

Thin, hydrogenated aluminum hydride films were deposited on silicon substrates using unbalanced magnetron (UBM) sputtering of a high purity aluminum target under electrically grounded conditions. Argon was used as sputtering gas and hydrogenation was carried out by diluting the growth plasma with hydrogen. The effect of hydrogen partial pressure on the final concentration of trapped elements including hydrogen has been studied using ion beam analysis (IBA) techniques. Moreover, in-situ thermal stability of trapped hydrogen in the film was carried out using Rutherford Backscattering Spectrometry (RBS), Non-Rutherford Backscattering Spectrometry (NRBS) and Elastic Recoil Detection Analysis (ERDA). Microstructure of the film was investigated by SEM analysis. Hydrogen content in the thin films was found decreasing as the films were heated above 110 °C in vacuum.

Detection of gain enhancement in laser-induced fluorescence of rhodamine B lasing dye by silicon dioxide nanostructures-coated cavity

NASA Astrophysics Data System (ADS)

Al-Tameemi, Mohammed N. A.

2018-03-01

In this work, nanostructured silicon dioxide films are deposited by closed-field unbalanced direct-current (DC) reactive magnetron sputtering technique on two sides of quartz cells containing rhodamine B dye dissolved in ethanol with 10‒5 M concentration as a random gain medium. The preparation conditions are optimized to prepare highly pure SiO2 nanostructures with a minimum particle size of about 20 nm. The effect of SiO2 films as external cavity for the random gain medium is determined by the laser-induced fluorescence of this medium, and an increase of about 200% in intensity is observed after the deposition of nanostructured SiO2 thin films on two sides of the dye cell.

Selective enrichment of volatiles confirmed

NASA Astrophysics Data System (ADS)

de Pater, Imke

2018-04-01

Hydrogen sulfide gas is detected above Uranus's main cloud deck, confirming the prevalence of H2S ice particles as the main cloud component and a strongly unbalanced nitrogen/sulfur ratio in the planet's deep atmosphere.

Around Marshall

NASA Image and Video Library

1995-07-08

Marshall researchers, in the Astrionics lab, study rotating unbalanced mass devices. These require less power, and are lighter than current devices used for scanning images, a slice at a time. They have a wide range of space-based applications.

Selective enrichment of volatiles confirmed

NASA Astrophysics Data System (ADS)

de Pater, Imke

2018-05-01

Hydrogen sulfide gas is detected above Uranus's main cloud deck, confirming the prevalence of H2S ice particles as the main cloud component and a strongly unbalanced nitrogen/sulfur ratio in the planet's deep atmosphere.

Large Unbalanced Credit Scoring Using Lasso-Logistic Regression Ensemble

PubMed Central

Wang, Hong; Xu, Qingsong; Zhou, Lifeng

2015-01-01

Recently, various ensemble learning methods with different base classifiers have been proposed for credit scoring problems. However, for various reasons, there has been little research using logistic regression as the base classifier. In this paper, given large unbalanced data, we consider the plausibility of ensemble learning using regularized logistic regression as the base classifier to deal with credit scoring problems. In this research, the data is first balanced and diversified by clustering and bagging algorithms. Then we apply a Lasso-logistic regression learning ensemble to evaluate the credit risks. We show that the proposed algorithm outperforms popular credit scoring models such as decision tree, Lasso-logistic regression and random forests in terms of AUC and F-measure. We also provide two importance measures for the proposed model to identify important variables in the data. PMID:25706988

Design Safety Used in NASA's Human-rated Primary Lithium Batteries

NASA Technical Reports Server (NTRS)

Jeevarajan, J.

2013-01-01

Single cell tests were benign for external short, inadvertent charge and overdischarge into reversal up to 4.5 A. At lower current loads cells die (may be due to excessive dendrite formation) benignly. String level external short circuits lead to an unbalanced overdischarge, with one cell going into reversal. The result is catastrophic violent venting. Unbalanced string overdischarges at different currents causes catastrophic violent venting also. Heat-to-vent is very dramatic displaying violent venting Simulated internal short is also catastrophic and displays violent venting. Battery is not UL-rated; hence does not have dual-fault tolerance or tolerance to inherent cell tolerance to failures Battery Design for NASA JSC's human-rated application for use on ISS was changed to include two bypass diodes per cell to provide for two-failure tolerance to overdischarge into reversal (and external short) hazards.

IEEE 342 Node Low Voltage Networked Test System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneider, Kevin P.; Phanivong, Phillippe K.; Lacroix, Jean-Sebastian

The IEEE Distribution Test Feeders provide a benchmark for new algorithms to the distribution analyses community. The low voltage network test feeder represents a moderate size urban system that is unbalanced and highly networked. This is the first distribution test feeder developed by the IEEE that contains unbalanced networked components. The 342 node Low Voltage Networked Test System includes many elements that may be found in a networked system: multiple 13.2kV primary feeders, network protectors, a 120/208V grid network, and multiple 277/480V spot networks. This paper presents a brief review of the history of low voltage networks and how theymore » evolved into the modern systems. This paper will then present a description of the 342 Node IEEE Low Voltage Network Test System and power flow results.« less

Characteristics of W Doped Nanocrystalline Carbon Films Prepared by Unbalanced Magnetron Sputtering.

PubMed

Park, Yong Seob; Park, Chul Min; Kim, Nam-Hoon; Kim, Jae-Moon

2016-05-01

Nanocrystalline tungsten doped carbon (WC) films were prepared by unbalanced magnetron sputtering. Tungsten was used as the doping material in carbon thin films with the aim of application as a contact strip in an electric railway. The structural, physical, and electrical properties of the fabricated WC films with various DC bias voltages were investigated. The films had a uniform and smooth surface. Hardness and frication characteristics of the films were improved, and the resistivity and sheet resistance decreased with increasing negative DC bias voltage. These results are associated with the nanocrystalline WC phase and sp(2) clusters in carbon networks increased by ion bombardment enhanced with increasing DC bias voltage. Consequently, the increase of sp(2) clusters containing WC nanocrystalline in the carbon films is attributed to the improvement in the physical and electrical properties.

Green-wave control of an unbalanced two-route traffic system with signals

NASA Astrophysics Data System (ADS)

Tobita, Kazuhiro; Nagatani, Takashi

2013-11-01

We introduce the preference parameter into the two-route dynamic model proposed by Wahle et al. The parameter represents the driver’s preference for the route choice. When the driver prefers a route, the traffic flow on route A does not balance with that on route B. We study the signal control for the unbalanced two-route traffic flow at the tour-time feedback strategy where the vehicles move ahead through a series of signals. The traffic signals are controlled by both cycle time and phase shift (offset time). We find that the mean tour time can be balanced by selecting the offset time successfully. We derive the relationship between the mean tour time and offset time (phase shift). Also, the dependences of the mean density and mean current on the offset time are derived.

Detection, Evaluation, and Optimization of Optical Signals Generated by Fiber Optic Bragg Gratings Under Dynamic Excitations

NASA Technical Reports Server (NTRS)

Adamovsky, Grigory; Lekki, John; Lock, James A.

2002-01-01

The dynamic response of a fiber optic Bragg grating to mechanical vibrations is examined both theoretically and experimentally. The theoretical expressions describing the consequences of changes in the grating's reflection spectrum are derived for partially coherent beams in an interferometer. The analysis is given in terms of the dominant wavelength, optical bandwidth, and optical path difference of the interfering signals. Changes in the reflection spectrum caused by a periodic stretching and compression of the grating were experimentally measured using an unbalanced Michelson interferometer, a Michelson interferometer with a non-zero optical path difference. The interferometer's sensitivity to changes in dominant wavelength of the interfering beams was measured as a function of interferometer unbalance and was compared to theoretical predictions. The theoretical analysis enables the user to determine the optimum performance for an unbalanced interferometer.

Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain.

PubMed

Schleiermacher, Gudrun; Bourdeaut, Franck; Combaret, Valérie; Picrron, Gaelle; Raynal, Virginie; Aurias, Alain; Ribeiro, Agnes; Janoueix-Lerosey, Isabelle; Delattre, Olivier

2005-05-05

In neuroblastoma, the most frequent genetic alterations are unbalanced translocations involving chromosome 17. To gain insights into these rearrangements, we have characterized a previously identified der(1)t(1;17) of the CLB-Bar cell line. The 17q breakpoint was mapped by FISH. Subsequently, a rearranged fragment was identified by Southern analysis, cloned in a lambda vector and sequenced. The chromosome rearrangement is more complex than expected due to the presence of an interstitial 4p telomeric sequence between chromosome 1p and 17q. Three different genes, which may play a role in neuroblastoma development, are disrupted by the translocation breakpoints. Indeed, the 3'UTR of the PIP5K2B gene on chromosome 17q is directly fused to the (TTAGGG)n repeat of the chromosome 4p telomere, and the (1;4) fusion disrupts the MACF1 (microtubule-actin crosslinking factor 1) and POLN genes, respectively. Interestingly, the (1;4) fusion was present at diagnosis and at relapse, whereas the (4;17) fusion was detected at relapse only, leading to a secondary 17q gain confirmed by array CGH therefore indicating that 17q gain may not be a primary event in neuroblastoma. Finally, screening of a panel of neuroblastoma cell lines identified interstitial telomeric sequences in three other cases, suggesting that this may be a recurrent mechanism leading to unbalanced translocations in neuroblastoma.

Sperm FISH analysis of a 44,X,der(Y),t(Y;15)(q12;q10)pat,rob(13;14)(q10;q10)mat complex chromosome rearrangement.

PubMed

Ferfouri, F; Boitrelle, F; Clement, P; Molina Gomes, D; Selva, J; Vialard, F

2014-06-01

Complex chromosome rearrangements (CCR) with two independent chromosome rearrangements are rare. Although CCRs lead to high unbalanced gamete rates, data on meiotic segregation in this context are scarce. A male patient was referred to our clinic as part of a family screening programme prompted by the observation of a 44,X,der(Y),t(Y;15)(q12;q10)pat,rob(13;14)(q10;q10)mat karyotype in his brother. Karyotyping identified the same CCR. Sperm FISH (with locus-specific probes for the segments involved in the translocations and nine chromosomes not involved in both rearrangements) was used to investigate the rearrangements meiotic segregation products and establish whether or not an inter-chromosomal effect was present. Sperm nuclear DNA fragmentation was also evaluated. For rob(13;14) and der(Y), the proportions of unbalanced products were, respectively, 26.4% and 60.6%. Overall, 70.3% of the meiotic segregation products were unbalanced. No evidence of an inter-chromosomal effect was found, and the sperm nuclear DNA fragmentation rate was similar to our laboratory's normal cut-off value. In view of previously published sperm FISH analyses of Robertsonian translocations (and even though the mechanism is still unknown), we hypothesise that cosegregation of der(Y) and rob(13;14) could modify rob(13;14) meiotic segregation. © 2013 Blackwell Verlag GmbH.

Unbalanced translocation 6p/16q (partial monosomy 6p and trisomy 16q): prenatal diagnosis and cytogenetics.

PubMed

Puhl, Alexander G; Zelazny, Julia; Galetzka, Danuta; Skala, Christine; Frey-Mahn, Gabriele; Wellek, Brigitte; Koelbl, Heinz

2010-06-01

Unbalanced translocation 6p/16q in one fetus is a very rare event and the prenatal sonographic findings have never been published before. We will give a short overview of the literature along with a case report focussing on prenatal ultrasound features and molecular cytogenetic analysis. A 21-year-old primigravid woman presented with a singleton pregnancy at 19 weeks' gestation. The fetus revealed a mild hydrocephalus, a ventricular septal defect (VSD), a Dandy-Walker malformation as well as an intrauterine growth retardation (IUGR) and limb anomalities. MLPA analysis from amniotic fluid cells showed an unbalanced translocation from the subtelomeric region of chromosome 6p to the subtelomeric region of chromosome 16q. Karyotype of the fetus was 46, XX.ishder(6)t(6;16)(p2?5;q?13)(pVYS246A+, pVYS228B-, pVYS229A+). Despite the karyotype the mother decided not to interrupt pregnancy. The fetus died in utero within the 39th week of gestation and was delivered vaginally after labour induction, with a birth weight of 1815g. Prenatal FISH and MLPA studies can be very important to help outline the chromosomal area of deletion and duplication and the sonographic findings forebode the cytogenetic region of interest. Subsequent to the processing of the case, a complete Medline search was conducted to review previous cases with similar genetic alterations. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Genotype/phenotype analysis in a male patient with partial trisomy 4p and monosomy 20q due to maternal reciprocal translocation (4;20): A case report.

PubMed

Wu, Dong; Zhang, Hui; Hou, Qiaofang; Wang, Hongdan; Wang, Tao; Liao, Shixiu

2017-11-01

Translocations are the most frequent structural aberration in the human genome. Carriers of balanced chromosome rearrangement exhibit an increased risk of abortion and/or a chromosomally‑unbalanced child. The present study reported a clinical and cytogenetic analysis of a child who exhibited typical trisomy 4p and monosomy 20q features, including intellectual disability, delayed speech, tall stature, seizures and facial dysmorphism. The karyotype of the proband exhibited 46, XY, add(20) (q13.3). The karyotype of the mother indicated a balanced translocation karyotype: 46, XX, t(4;20) (p15.2;q13.1). The array‑based comparative genomic hybridization (aCGH) analysis identified partial trisomy of the short arm of chromosome 4 and partial monosomy of distal 20q in the proband due to maternal balanced reciprocal translocation 4;20. The analysis of genotype/phenotype correlation demonstrated that fibroblast growth factor receptor 3 and msh homeobox 1 may be the important genes for 4p duplication, and that potassium voltage‑gated channel subfamily Q member 2, myelin transcription factor 1 and cholinergic receptor nicotinic α4 subunit may be the important genes for 20q deletion. To the best of our knowledge, the present study was the first to report an unbalanced translocation involving chromosomes 4p and 20q. The present study additionally demonstrated that aCGH analysis is able to reliably detect unbalanced submicroscopic chromosomal aberrations.

Looking for solutions: gender differences in relationship and parenting challenges among low-income, young parents.

PubMed

Albritton, Tashuna; Angley, Meghan; Grandelski, Valen; Hansen, Nathan; Kershaw, Trace

2014-12-01

The need for parenting and relationship strengthening programs is important among low-income minority parents where the burden of relational and parental stressors contributes to relationship dissolution. We examine these stressors among young parents. Data were collected from four focus groups (N = 35) with young parents. Data were audio-recorded and transcribed. Inductive coding was used to generate themes and codes, and analysis was completed using NVivo. Relationship and parenting challenges, values, and areas of need were the three major themes that emerged. Women's relationship challenges were family interference and unbalanced parenting, and men reported feeling disrespected and having limited finances. Common relationship challenges for women and men were family interference and unbalanced parenting. Both genders valued trust, communication, and honesty in relationships. Areas of need for women and men included: improving communication and understanding the impact of negative relationships on current relationships. Parenting challenges for women were unbalanced parenting, child safety, and feeling unprepared to parent; men reported limited finances. Both genders valued quality time with child to instill family morals. Areas of need for women and men included learning child discipline techniques and increasing knowledge about child development. Finally, women and men have relationship and parenting similarities and differences. Young parents are interested in learning how to improve relationships and co-parent to reduce relationship distress, which could reduce risk behaviors and improve child outcomes. © 2014 Family Process Institute.

Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis.

PubMed

Emrath, Elizabeth T; Fortenberry, James D; Travers, Curtis; McCracken, Courtney E; Hebbar, Kiran B

2017-07-01

To evaluate outcomes in patients receiving balanced fluids for resuscitation in pediatric severe sepsis. Observational cohort review of prospectively collected data from a large administrative database. PICUs from 43 children's hospitals. PICU patients diagnosed with severe sepsis. None. We reviewed data from the Pediatric Health Information System database from 2004 to 2012. Children with pediatric severe sepsis receiving balanced fluids for resuscitation in the first 24 and 72 hours of treatment were compared to those receiving unbalanced fluids. Thirty-six thousand nine hundred eight patients met entry criteria for analysis. Two thousand three hundred ninety-eight patients received exclusively balanced fluids at 24 hours and 1,641 at 72 hours. After propensity matching, the 72-hour balanced fluids group had lower mortality (12.5% vs 15.9%; p = 0.007; odds ratio, 0.76; 95% CI, 0.62-0.93), lower prevalence of acute kidney injury (16.0% vs 19.2%; p = 0.028; odds ratio, 0.82; 95% CI, 0.68-0.98), and fewer vasoactive infusion days (3.0 vs 3.3 d; p < 0.001) when compared with the unbalanced fluids group. In this retrospective analysis carried out by propensity matching, exclusive use of balanced fluids in pediatric severe sepsis patients for the first 72 hours of resuscitation was associated with improved survival, decreased prevalence of acute kidney injury, and shorter duration of vasoactive infusions when compared with exclusive use of unbalanced fluids.

Relatives with opposite chromosome constitutions, rec(10)dup(10p)inv(10)(p15.1q26.12) and rec(10)dup(10q)inv(10)(p15.1q26.12), due to a familial pericentric inversion.

PubMed

Ciuladaite, Zivile; Preiksaitiene, Egle; Utkus, Algirdas; Kučinskas, Vaidutis

2014-01-01

Large pericentric inversions in chromosome 10 are rare chromosomal aberrations with only few cases of familial inheritance. Such chromosomal rearrangements may lead to production of unbalanced gametes. As a result of a recombination event in the inversion loop, 2 recombinants with duplicated and deficient chromosome segments, including the regions distal to the inversion, may be produced. We report on 2 relatives in a family with opposite terminal chromosomal rearrangements of chromosome 10, i.e. rec(10)dup(10p)inv(10) and rec(10)dup(10q)inv(10), due to familial pericentric inversion inv(10)(p15.1q26.12). Based on array-CGH results, we characterized the exact genomic regions involved and compared the clinical features of both patients with previous reports on similar pericentric inversions and regional differences within 10p and 10q. The fact that both products of recombination are viable indicates a potentially high recurrence risk of unbalanced offspring. This report of unbalanced rearrangements in chromosome 10 in 2 generations confirms the importance of screening for terminal imbalances in patients with idiopathic intellectual disability by molecular cytogenetic techniques such as FISH, MLPA or microarrays. It also underlines the necessity for FISH to define structural characteristics of such cryptic intrachromosomal rearrangements and the underlying cytogenetic mechanisms. © 2014 S. Karger AG, Basel.

Interstitial Nephritis

MedlinePlus

... A reaction to a medicine, such as certain antibiotics. Too much of certain medicines. These include diuretics (water pills) or pain relievers, such as acetaminophen, aspirin, or a non-steroidal anti-inflammatory drug (NSAID). Unbalanced levels of certain nutrients in ...

Electromagnetic coupling to centimeter-scale mechanical membrane resonators via RF cylindrical cavities

NASA Astrophysics Data System (ADS)

Martinez, Luis A.; Castelli, Alessandro R.; Delmas, William; Sharping, Jay E.; Chiao, Raymond

2016-11-01

We present experimental and theoretical results for the excitation of a mechanical oscillator via radiation pressure with a room-temperature system employing a relatively low-(Q) centimeter-size mechanical oscillator coupled to a relatively low-Q standard three-dimensional radio-frequency (RF) cavity resonator. We describe the forces giving rise to optomechanical coupling using the Maxwell stress tensor and show that nanometer-scale displacements are possible and experimentally observable. The experimental system is composed of a 35 mm diameter silicon nitride membrane sputtered with a 300 nm gold conducting film and attached to the end of a RF copper cylindrical cavity. The RF cavity is operated in its {{TE}}011 mode and amplitude modulated on resonance with the fundamental drum modes of the membrane. Membrane motion is monitored using an unbalanced, non-zero optical path difference, optically filtered Michelson interferometer capable of measuring sub-nanometer displacements.

Magnetohydrodynamic actuation of droplets for millimetric planar fluidic systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmadi, A., E-mail: ali.ahmadi@ubc.ca; McDermid, C. M.; Markley, L.

2016-01-04

In this work, a magnetohydrodynamic method is proposed for the actuation of droplets in small-scale planar fluidic systems, providing an alternative to commonly used methods such as electrowetting-on-dielectric. Elementary droplet-based operations, including transport, merging, and mixing, are demonstrated. The forces acting on millimetric droplets are carefully investigated, with a primary focus on the magnetic actuation force and on the unbalanced capillary forces that arise due to hysteresis. A super-hydrophobic channel is 3D printed to guide the droplets, with thin wires installed as contact electrodes and permanent magnets providing a static magnetic field. It is shown that droplet motion is enhancedmore » by increasing the droplet size and minimizing the electrode contact surface. The effects of channel geometry on threshold voltage and minimum moveable droplet volume are characterized. Finally, the presence of electrolysis is investigated and mitigating strategies are discussed.« less

Industrial-hygiene characterization of ethylene oxide exposures of hospital and nursing-home workers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ringenburg, V.L.; Elliott, L.J.; Morelli-Schroth, P.

Industrial-hygiene surveys were conducted at 12 hospitals and one nursing home to determine possible employee exposure to ethylene oxide (EtO). Different types of exposure situations existed at each of the facilities as a result of various engineering controls, administrative controls and work practices. Sampling indicated that the time-weighted averages (TWAs) of exposure over periods of 36 to 724 minutes ranged from below the limit of detection to 6.7 parts per million (ppm). Personal short-term exposure levels covering 2 to 30 minutes ranged from less than the limit of detection to 103.2ppm. Factors found to be responsible for these higher-than-permissible levelsmore » of EtO exposure included improper installation or lack of engineering controls (such as improper placement of the sterilizing operations), unbalanced ventilation systems, and lack of administrative controls resulting in inappropriate work practices.« less

High-speed rail turnout literature review : final report.

DOT National Transportation Integrated Search

2016-08-01

High-speed rail (HSR) turnout design criteria generally address unbalanced lateral acceleration or cant deficiency (CD), cant deficiency change rate (CDCR), and entry and exit jerk. Various countries have adopted different design values for their HSR...

Familial translocation t(6;20)(p21;p13) resulting in partial trisomy 6p and partial monosomy 20p: report of a new case and review of the literature.

PubMed

Berner, A L; Bağci, S; Wohlleber, E; Engels, E; Müller, A; Bartmann, P; Weber, R G; Reutter, H

2012-01-01

Carriers of completely balanced chromosomal translocations have all necessary genetic information. Nevertheless, because of the possibility of maldistribution during gametogenesis, they are at increased risk for infertility, miscarriage, stillbirth or having a child with congenital anomalies including mental retardation. As postnatal clinical reports are infrequent, prediction of clinical course for specific unbalanced karyotypes diagnosed during pregnancy remains difficult. Here, we report the 6th case of partial trisomy 6p and partial monosomy 20p due to an unbalanced adjacent-1 segregation of the rare familial translocation t(6;20)(p21;p13). We give a thorough clinical description of the present case, demonstrating broad phenotypic overlap with the 5 previously published cases reviewed here, providing important data on postnatal outcome. Copyright © 2012 S. Karger AG, Basel.

Generation of vortex array laser beams with Dove prism embedded unbalanced Mach-Zehnder interferometer

NASA Astrophysics Data System (ADS)

Chu, Shu-Chun

2009-02-01

This paper introduces a scheme for generation of vortex laser beams from a solid-state laser with off-axis laser-diode pumping. The proposed system consists of a Dove prism embedded in an unbalanced Mach-Zehnder interferometer configuration. This configuration allows controlled construction of p × p vortex array beams from Ince-Gaussian modes, IGep,p modes. An incident IGe p,p laser beam of variety order p can easily be generated from an end-pumped solid-state laser with an off-axis pumping mechanism. This study simulates this type of vortex array laser beam generation and discusses beam propagation effects. The formation of ordered transverse emission patterns have applications in a variety of areas such as optical data storage, distribution, and processing that exploit the robustness of soliton and vortex fields and optical manipulations of small particles and atoms in the featured intensity distribution.

The research of hourglass worm dynamic balancing simulation based on SolidWorks motion

NASA Astrophysics Data System (ADS)

Wang, Zhuangzhuang; Yang, Jie; Liu, Pingyi; Zhao, Junpeng

2018-02-01

Hourglass worm is extensively used in industry due to its characteristic of heavy-load and a large reduction ratio. Varying sizes of unbalanced mass distribution appeared in the design of a single head worm. With machines developing towards higher speed and precision, the vibration and shock caused by the unbalanced mass distribution of rotating parts must be considered. Therefore, the balance grade of these parts must meet higher requirements. A method based on theoretical analysis and SolidWorks motion software simulation is presented in this paper; the virtual dynamic balance simulation test of the hourglass worm was carried out during the design of the product, so as to ensure that the hourglass worm meet the requirements of dynamic balance in the design process. This can effectively support the structural design of the hourglass worm and provide a way of thinking and designing the same type of products.

Vibration signal correction of unbalanced rotor due to angular speed fluctuation

NASA Astrophysics Data System (ADS)

Cao, Hongrui; He, Dong; Xi, Songtao; Chen, Xuefeng

2018-07-01

The rotating speed of a rotor is hardly constant in practice due to angular speed fluctuation, which affects the balancing accuracy of the rotor. In this paper, the effect of angular speed fluctuation on vibration responses of the unbalanced rotor is analyzed quantitatively. Then, a vibration signal correction method based on zoom synchrosqueezing transform (ZST) and tacholess order tracking is proposed. The instantaneous angular speed (IAS) of the rotor is extracted by the ZST firstly and then used to calculate the instantaneous phase. The vibration signal is further resampled in angular domain to reduce the effect of angular speed fluctuation. The signal obtained in angular domain is transformed into order domain using discrete Fourier transform (DFT) to estimate the amplitude and phase of the vibration signal. Simulated and experimental results show that the proposed method can successfully correct the amplitude and phase of the vibration signal due to angular speed fluctuation.

Simulative and experimental investigation on stator winding turn and unbalanced supply voltage fault diagnosis in induction motors using Artificial Neural Networks.

PubMed

Lashkari, Negin; Poshtan, Javad; Azgomi, Hamid Fekri

2015-11-01

The three-phase shift between line current and phase voltage of induction motors can be used as an efficient fault indicator to detect and locate inter-turn stator short-circuit (ITSC) fault. However, unbalanced supply voltage is one of the contributing factors that inevitably affect stator currents and therefore the three-phase shift. Thus, it is necessary to propose a method that is able to identify whether the unbalance of three currents is caused by ITSC or supply voltage fault. This paper presents a feedforward multilayer-perceptron Neural Network (NN) trained by back propagation, based on monitoring negative sequence voltage and the three-phase shift. The data which are required for training and test NN are generated using simulated model of stator. The experimental results are presented to verify the superior accuracy of the proposed method. Copyright © 2015. Published by Elsevier Ltd.

Effect of unbalanced diets on the long-term metabolism of a toxicant. 1. Lead in rats: preliminary note.

PubMed

Baldini, M; Coni, E; Mantovani, A; Stacchini, A; Zanasi, F

1989-01-01

The aim of this study was the evaluation of the effect of dietary imbalances on absorption and distribution of lead in the female Sprague-Dawley rat. In this note preliminary results on the relationship between blood concentrations of lead and unbalanced diets are presented. Hyperproteic, hyperglycidic, hyperlipidic and balanced diets were prepared, and most of them included 15 mg/kg lead. Blood samples were collected at day 0, 21, 36, and 95 of the diets and analyzed by anodic stripping voltammetry (ASV). Lead uptake as a function of feed consumption was found to decrease in the order: balanced, hyperproteic and hyperglycidic, hyperlipidic diet. On the other hand lead blood levels were as follows (decreasing order): hyperlipidic, hyperproteic, hyperglycidic, balanced. Further research is being carried out on the influences of dietary imbalances on whole-body distribution of lead.

Visualization in mechanics: the dynamics of an unbalanced roller

NASA Astrophysics Data System (ADS)

Cumber, Peter S.

2017-04-01

It is well known that mechanical engineering students often find mechanics a difficult area to grasp. This article describes a system of equations describing the motion of a balanced and an unbalanced roller constrained by a pivot arm. A wide range of dynamics can be simulated with the model. The equations of motion are embedded in a graphical user interface for its numerical solution in MATLAB. This allows a student's focus to be on the influence of different parameters on the system dynamics. The simulation tool can be used as a dynamics demonstrator in a lecture or as an educational tool driven by the imagination of the student. By way of demonstration the simulation tool has been applied to a range of roller-pivot arm configurations. In addition, approximations to the equations of motion are explored and a second-order model is shown to be accurate for a limited range of parameters.

Low-cycle thermal fatigue

NASA Technical Reports Server (NTRS)

Halford, G. R.

1986-01-01

A state-of-the-art review is presented of the field of thermal fatigue. Following a brief historical review, the concept is developed that thermal fatigue can be viewed as processes of unbalanced deformation and cracking. The unbalances refer to dissimilar mechanisms occurring in opposing halves of thermal fatigue loading and unloading cycles. Extensive data summaries are presented and results are interpreted in terms of the unbalanced processes involved. Both crack initiation and crack propagation results are summarized. Testing techniques are reviewed, and considerable discussion is given to a technique for thermal fatigue simulation, known as the bithermal fatigue test. Attention is given to the use of isothermal life prediction methods for the prediction of thermal fatigue lives. Shortcomings of isothermally-based life prediction methods are pointed out. Several examples of analyses and thermal fatigue life predictions of high technology structural components are presented. Finally, numerous dos and don'ts relative to design against thermal fatigue are presented.

Improved power control using optimal adjustable coefficients for three-phase photovoltaic inverter under unbalanced grid voltage.

PubMed

Wang, Qianggang; Zhou, Niancheng; Lou, Xiaoxuan; Chen, Xu

2014-01-01

Unbalanced grid faults will lead to several drawbacks in the output power quality of photovoltaic generation (PV) converters, such as power fluctuation, current amplitude swell, and a large quantity of harmonics. The aim of this paper is to propose a flexible AC current generation method by selecting coefficients to overcome these problems in an optimal way. Three coefficients are brought in to tune the output current reference within the required limits of the power quality (the current harmonic distortion, the AC current peak, the power fluctuation, and the DC voltage fluctuation). Through the optimization algorithm, the coefficients can be determined aiming to generate the minimum integrated amplitudes of the active and reactive power references with the constraints of the inverter current and DC voltage fluctuation. Dead-beat controller is utilized to track the optimal current reference in a short period. The method has been verified in PSCAD/EMTDC software.

Improved Power Control Using Optimal Adjustable Coefficients for Three-Phase Photovoltaic Inverter under Unbalanced Grid Voltage

PubMed Central

Wang, Qianggang; Zhou, Niancheng; Lou, Xiaoxuan; Chen, Xu

2014-01-01

Unbalanced grid faults will lead to several drawbacks in the output power quality of photovoltaic generation (PV) converters, such as power fluctuation, current amplitude swell, and a large quantity of harmonics. The aim of this paper is to propose a flexible AC current generation method by selecting coefficients to overcome these problems in an optimal way. Three coefficients are brought in to tune the output current reference within the required limits of the power quality (the current harmonic distortion, the AC current peak, the power fluctuation, and the DC voltage fluctuation). Through the optimization algorithm, the coefficients can be determined aiming to generate the minimum integrated amplitudes of the active and reactive power references with the constraints of the inverter current and DC voltage fluctuation. Dead-beat controller is utilized to track the optimal current reference in a short period. The method has been verified in PSCAD/EMTDC software. PMID:25243215

Crash Frequency Analysis Using Hurdle Models with Random Effects Considering Short-Term Panel Data

PubMed Central

Chen, Feng; Ma, Xiaoxiang; Chen, Suren; Yang, Lin

2016-01-01

Random effect panel data hurdle models are established to research the daily crash frequency on a mountainous section of highway I-70 in Colorado. Road Weather Information System (RWIS) real-time traffic and weather and road surface conditions are merged into the models incorporating road characteristics. The random effect hurdle negative binomial (REHNB) model is developed to study the daily crash frequency along with three other competing models. The proposed model considers the serial correlation of observations, the unbalanced panel-data structure, and dominating zeroes. Based on several statistical tests, the REHNB model is identified as the most appropriate one among four candidate models for a typical mountainous highway. The results show that: (1) the presence of over-dispersion in the short-term crash frequency data is due to both excess zeros and unobserved heterogeneity in the crash data; and (2) the REHNB model is suitable for this type of data. Moreover, time-varying variables including weather conditions, road surface conditions and traffic conditions are found to play importation roles in crash frequency. Besides the methodological advancements, the proposed technology bears great potential for engineering applications to develop short-term crash frequency models by utilizing detailed data from field monitoring data such as RWIS, which is becoming more accessible around the world. PMID:27792209

A level-set method for two-phase flows with moving contact line and insoluble surfactant

NASA Astrophysics Data System (ADS)

Xu, Jian-Jun; Ren, Weiqing

2014-04-01

A level-set method for two-phase flows with moving contact line and insoluble surfactant is presented. The mathematical model consists of the Navier-Stokes equation for the flow field, a convection-diffusion equation for the surfactant concentration, together with the Navier boundary condition and a condition for the dynamic contact angle derived by Ren et al. (2010) [37]. The numerical method is based on the level-set continuum surface force method for two-phase flows with surfactant developed by Xu et al. (2012) [54] with some cautious treatment for the boundary conditions. The numerical method consists of three components: a flow solver for the velocity field, a solver for the surfactant concentration, and a solver for the level-set function. In the flow solver, the surface force is dealt with using the continuum surface force model. The unbalanced Young stress at the moving contact line is incorporated into the Navier boundary condition. A convergence study of the numerical method and a parametric study are presented. The influence of surfactant on the dynamics of the moving contact line is illustrated using examples. The capability of the level-set method to handle complex geometries is demonstrated by simulating a pendant drop detaching from a wall under gravity.

Stress responsiveness in adult life: influence of mother's diet in late pregnancy.

PubMed

Reynolds, Rebecca M; Godfrey, Keith M; Barker, Mary; Osmond, Clive; Phillips, David I W

2007-06-01

Men and women whose mothers ate an unbalanced high-protein, low-carbohydrate diet in late pregnancy have raised blood pressure. We recently showed that they also have raised fasting plasma cortisol concentrations. Because raised fasting cortisol concentrations probably reflect a greater response to the stress of fasting and venesection, we suspected that this diet may have led to increased stress responsiveness in the adult offspring. The aim was to determine whether an unbalanced high-protein diet during pregnancy is associated with increased cortisol secretion in response to psychological stress in the offspring. Salivary cortisol concentrations were measured during a modified Trier Social Stress Test in 70 men and women aged 36.3 yr whose mothers had taken part in a dietary intervention in which they were advised to eat 1 pound (0.45 kg) of red meat daily during pregnancy and to avoid carbohydrate-rich foods. The offspring of women who reported greater consumption of meat and fish in the second half of pregnancy had higher cortisol concentrations during the Trier Test. Compared with the offspring of mothers who had reported eating no more than 13 meat/fish portions per week, the average cortisol concentrations were raised by 22% (95% confidence interval, 13 to 71%) and 46% (5 to 103%) in the offspring of those eating 14-16 and at least 17 portions per week, respectively. These findings provide the first human evidence that an unbalanced high protein maternal diet during late pregnancy leads to increased cortisol secretion in response to psychological stress in the offspring.

"Double-hit" chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain.

PubMed

Chapiro, Elise; Lesty, Claude; Gabillaud, Clémentine; Durot, Eric; Bouzy, Simon; Armand, Marine; Le Garff-Tavernier, Magali; Bougacha, Nadia; Struski, Stéphanie; Bidet, Audrey; Laharanne, Elodie; Barin, Carole; Veronese, Lauren; Prié, Nolwen; Eclache, Virginie; Gaillard, Baptiste; Michaux, Lucienne; Lefebvre, Christine; Gaillard, Jean-Baptiste; Terré, Christine; Penther, Dominique; Bastard, Christian; Nadal, Nathalie; Fert-Ferrer, Sandra; Auger, Nathalie; Godon, Catherine; Sutton, Laurent; Tournilhac, Olivier; Susin, Santos A; Nguyen-Khac, Florence

2018-03-01

Chronic lymphocytic leukemia (CLL) with 17p deletion (17p-) is associated with a lack of response to standard treatment and thus the worst possible clinical outcome. Various chromosomal abnormalities (including unbalanced translocations, deletions, ring chromosomes and isochromosomes) result in the loss of 17p and one copy of the TP53 gene. The objective of the present study was to determine whether the type of chromosomal abnormality leading to 17p- and the additional aberrations influenced the prognosis in a series of 195 patients with 17p-CLL. Loss of 17p resulted primarily from an unbalanced translocation (70%) with several chromosome partners (the most frequent being chromosome 18q), followed by deletion 17p (23%), monosomy 17 (8%), isochromosome 17q [i(17q)] (5%) and a ring chromosome 17 (2%). In a univariate analysis, monosomy 17, a highly complex karyotype (≥5 abnormalities), and 8q24 gain were associated with poor treatment-free survival, and i(17q) (P = .04), unbalanced translocations (P = .03) and 8q24 gain (P = .001) were significantly associated with poor overall survival. In a multivariate analysis, 8q24 gain remained a significant predictor of poor overall survival. We conclude that 17p deletion and 8q24 gain have a synergistic impact on outcome, and so patients with this "double-hit" CLL have a particularly poor prognosis. Systematic, targeting screening for 8q24 gain should therefore be considered in cases of 17p- CLL. © 2017 Wiley Periodicals, Inc.

Hierarchical structure graphitic-like/MoS2 film as superlubricity material

NASA Astrophysics Data System (ADS)

Gong, Zhenbin; Jia, Xiaolong; Ma, Wei; Zhang, Bin; Zhang, Junyan

2017-08-01

Friction and wear result in a great amount of energy loss and the invalidation of mechanical parts, thus it is necessary to minimize friction in practical application. In this study, the graphitic-like/MoS2 films with hierarchical structure were synthesized by the combination of pulse current plasma chemical-vapor deposition and medium frequency unbalanced magnetron sputtering in preheated environment. This hierarchical structure composite with multilayer nano sheets endows the films excellent tribological performance, which easily achieves macro superlubricity (friction coefficient ∼0.004) under humid air. Furthermore, it is expected that hierarchical structure of graphitic-like/MoS2 films could match the requirements of large scale, high bear-capacity and wear-resistance of actual working conditions, which could be widely used in the industrial production as a promising superlubricity material.

Experimental evaluation of a tuned electromagnetic damper for vibration control of cryogenic turbopump rotors

NASA Technical Reports Server (NTRS)

Dirusso, Eliseo; Brown, Gerald V.

1990-01-01

Experiments were performed on a passive tuned electromagnetic damper that could be used for damping rotor vibrations in cryogenic turbopumps for rocket engines. The tests were performed in a rig that used liquid nitrogen to produce cryogenic turbopump temperatures. This damper is most effective at cryogenic temperatures and is not a viable damper at room temperature. The unbalanced amplitude response of the rotor shaft was measured for undamped (baseline) and damped conditions at the critical speeds of the rotor (approx. 5900 to 6400 rpm) and the data were compared. The tests were performed for a speed range between 900 and 10 000 rpm. The tests revealed that the damper is very effective for damping single-mode narrow bandwidth amplitude response but is less effective in damping broadband response or multimode amplitude response.

Ostomy Surgery of the Bowel

MedlinePlus

... gum with moderation, as they may also cause gas. Constipation is often the result of an unbalanced diet or eating and drinking too little. After ostomy surgery, people should avoid large amounts of liquids with meals drink plenty of liquids between meals ...

Knee isokinetic performance following anterior cruciate ligament reconstruction: patellar tendon versus hamstrings graft.

PubMed

Machado, Felipe; Debieux, Pedro; Kaleka, Camila Cohen; Astur, Diego; Peccin, Maria Stella; Cohen, Moisés

2018-02-01

To compare knee isokinetic performance six months after reconstruction of the anterior cruciate ligament using grafts from either the patellar tendon or the hamstrings among patients who underwent the same rehabilitation protocol. Thirty-four patients were evaluated (17 with grafts from the patellar tendon and 17 with grafts from the hamstrings). Operated and non-operated knees were compared with regards to the variables of peak torque, work and the hamstring/quadriceps relationship at velocities of 60º/s and 180º/s and power of 180º/s after six months of surgery. The patients with ACL reconstruction using the patellar tendon (BPTB) showed quadriceps deficits for all variables, but the flexor musculature was balanced. In the hamstring group, both the extensors and the flexors showed deficits for the variables analyzed, except for hamstring power at 180º/s. Patients in the patellar tendon group had a greater quadriceps deficit compared with those in the hamstrings group. Patients in the hamstrings group had a greater muscular deficit in the flexor mechanism compared with the contralateral knee. An unbalanced H/Q ratio was observed regardless of graft type, but this was more evident in the BPTB group.

Metrics and experimental data for assessing unbalanced disassembly lines.

DOT National Transportation Integrated Search

2011-01-01

Disassembly lines are inherently multi-criteria, with balance having the possibility of : being one of the lower priorities. This is due to the fact that other criteria for example, : removing valuable or hazardous materials early on in the proce...

Bedload transport in a river confluence

NASA Astrophysics Data System (ADS)

Martín-Vide, J. P.; Plana-Casado, A.; Sambola, A.; Capapé, S.

2015-12-01

The confluence of the regulated Toltén River and its tributary the unregulated Allipén (south of Chile) has proved dynamic in the last decade. Daily bedload measurements with a Helley-Smith sampler, bed surveys, and grain-size distributions of the two rivers are obtained from a field campaign that lasts 3 months in high-flow season. The goals are to quantify total bedload and to understand the balance between tributary and main river and the bedload distribution in space and texture. The bedload transport varies 200-fold, with a maximum of 5000 t/day. The discharge varies five-fold, with a maximum of 900 m3/s. Two-thirds of the total bedload volume are transported through the deeper area of the cross section and gravel is predominant (64%). Average bedload volumes in the confluence seem unbalanced in favour of the tributary. Main river bedload transport is predominantly at below-capacity conditions, while the tributary bedload transport is at-capacity conditions. This is deemed the main reason of inaccuracy of the bedload predictors. The roles of entrainment into suspension, helical flow, partial transport, and mobile armour are discussed.

Preclinical models for obesity research

PubMed Central

Barrett, Perry; Morgan, Peter J.

2016-01-01

ABSTRACT A multi-dimensional strategy to tackle the global obesity epidemic requires an in-depth understanding of the mechanisms that underlie this complex condition. Much of the current mechanistic knowledge has arisen from preclinical research performed mostly, but not exclusively, in laboratory mouse and rat strains. These experimental models mimic certain aspects of the human condition and its root causes, particularly the over-consumption of calories and unbalanced diets. As with human obesity, obesity in rodents is the result of complex gene–environment interactions. Here, we review the traditional monogenic models of obesity, their contemporary optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes to recapitulate the complexity of human obesity. We critically appraise the strengths and weaknesses of these different models to explore the underlying mechanisms, including the neural circuits that drive behaviours such as appetite control. We also discuss the use of these models for testing and screening anti-obesity drugs, beneficial bio-actives, and nutritional strategies, with the goal of ultimately translating these findings for the treatment of human obesity. PMID:27821603

Tribological Behaviour of Ti:Ta-DLC Films Under Different Tribo-Test Conditions

NASA Astrophysics Data System (ADS)

Efeoglu, İhsan; Keleş, Ayşenur; Totik, Yaşar; Çiçek, Hikmet; Emine Süküroglu, Ebru

2018-01-01

Diamond-like carbon (DLC) films are suitable applicants for cutting tools due to their high hardness, low friction coefficient and wear rate. Doping metals in DLC films have been improved its tribological properties. In this study, titanium and tantalum doped hydrogenated DLC films were deposited by closed-field unbalanced magnetron sputtering system onto M2 high speed steels in Ar/N2/C2H2 atmosphere. The friction and wear properties of Ti:Ta-DLC film were investigated under different tribo-test conditions including in atmospheric pressure, distilled water, commercial oil and Ar atmosphere. The coated specimens were characterized by SEM and X-ray diffraction techniques. The bonding state of C-C (sp3) and C=C (sp2) were obtained with XPS. The tribological properties of Ti:Ta-DLC were investigated with pin-on-disc wear test. Hardness measurements performed by micro-indentation. Our results suggest that Ti:Ta-doped DLC film shows very dense columnar microstructure, high hardness (38.2 GPa) with low CoF (µ≈0.02) and high wear resistance (0.5E-6 mm3/Nm).

Effectiveness of exterior beam rotation prevention systems for bridge deck construction.

DOT National Transportation Integrated Search

2016-06-01

Bridge decks often overhang past the exterior girders in order to increase the width of the deck while limiting the required : number of longitudinal girders. The overhanging portion of the deck results in unbalanced eccentric loads to the exterior g...

Digital Libraries and the Continuum of Scholarly Communication.

ERIC Educational Resources Information Center

Borgman, Christine L.

2000-01-01

Explores the relationship between scholarly communication, an established research area receiving renewed interest, and digital libraries, a relatively new area of research. Stakeholders agree that the relationship structure inherent in scholarship has become unbalanced with the advent of electronic publishing, digital libraries, computer…

The role of activity complexes in the distribution of solar magnetic fields.

NASA Astrophysics Data System (ADS)

García de La Rosa, J. I.; Reyes, R. C.

Using published data on the large-scale distribution of solar activity, the authors conclude that the longlived coronal holes are formed and maintained by the unbalanced magnetic flux which developes at both extremes of the complexes of activity.

Meiotic segregation analysis in spermatozoa of pericentric inversion carriers using fluorescence in-situ hybridization.

PubMed

Morel, F; Laudier, B; Guérif, F; Couet, M L; Royère, D; Roux, C; Bresson, J L; Amice, V; De Braekeleer, M; Douet-Guilbert, N

2007-01-01

Pericentric inversions are structural chromosomal abnormalities resulting from two breaks, one on either side of the centromere, within the same chromosome, followed by 180 degrees rotation and reunion of the inverted segment. They can perturb spermatogenesis and lead to the production of unbalanced gametes through the formation of an inversion loop. We report here the analysis of the meiotic segregation in spermatozoa from six pericentric inversion carriers by multicolour fluorescence in-situ hybridization (FISH) and review the literature. The frequencies of the non-recombinant products (inversion or normal chromosomes) were 80% for the inv(20), 91.41% for the inv(12), 99.43% for the inv(2), 68.12% for the inv(1), 97% for the inv(8)(p12q21) and 60.94% for the inv(8)(p12q24.1). The meiotic segregation of 20 pericentric inversions (including ours) is now available. The frequency of unbalanced spermatozoa varies from 0 to 37.85%. The probability of a crossover within the inverted segment is affected by the chromosome and region involved, the length of the inverted segment and the location of the breakpoints. No recombinant chromosomes were produced when the inverted segment involved <30% of the chromosome length (independent of the size of the inverted segment). Between 30 and 50%, few recombinant chromosomes were produced, inducing a slightly increased risk of aneusomy of recombination in the offspring. The risk of aneusomy became very important when the inverted segment was >50% of the chromosome length. Studies on spermatozoa from inversion carriers help in the comprehension of the mechanisms of meiotic segregation. They should be integrated in the genetic exploration of the infertile men to give them a personalized risk assessment of unbalanced spermatozoa.

Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1/2 MAPK pathway.

PubMed

Zhang, Kai; Ding, Wei; Sun, Wei; Sun, Xiao-jiang; Xie, You-zhuan; Zhao, Chang-qing; Zhao, Jie

2016-01-01

Low back pain is associated with intervertebral disc degeneration (IVDD) due to cellular loss through apoptosis. Mechanical factors play an important role in maintaining the survival of the annulus fibrosus (AF) cells and the deposition of extracellular matrix. However, the mechanisms that excessive mechanical forces lead to AF cell apoptosis are not clear. The present study was to look for how AF cells sense mechanical changes. In vivo experiments, the involvement of mechanoreceptors in apoptosis was examined by RT-PCR and/or immunoblotting in the lumbar spine of rats subjected to unbalanced dynamic and static forces. In vitro experiments, we investigated apoptotic signaling pathways in untransfected and transfected AF cells with the lentivirus vector for rat β1 integrin overexpression after cyclic stretch. Apoptosis in AF cells was assessed using flow cytometry, Hoechst 33258 nuclear staining. Western blotting was used to analyze expression of β1 integrin and caspase-3 and ERK1/2 MAPK signaling molecules. In the rat IVDD model, unbalanced dynamic and static forces induced apoptosis of disc cells, which corresponded to decreased expression of β1 integrin. Cyclic stretch-induced apoptosis in rat AF cells correlated with the activation of caspase-3 and with decreased levels of β1 integrin and the phosphorylation levels of ERK1/2 activation level. However, the overexpression of β1 integrin in AF cells ameliorated cyclic stretch-induced apoptosis and decreased caspase-3 activation. Furthermore, ERK1/2-specific inhibitor promotes apoptosis in vector β1-infected AF cells. These results suggest that the disruption of β1 integrin signaling may underlie disc cell apoptosis induced by mechanical stress. Further work is necessary to fully elucidate the pathophysiological mechanisms that underlie IVDD caused by unbalanced dynamic and static forces.

Cryptic deletions are a common finding in “balanced” reciprocal and complex chromosome rearrangements: a study of 59 patients

PubMed Central

De Gregori, M; Ciccone, R; Magini, P; Pramparo, T; Gimelli, S; Messa, J; Novara, F; Vetro, A; Rossi, E; Maraschio, P; Bonaglia, M C; Anichini, C; Ferrero, G B; Silengo, M; Fazzi, E; Zatterale, A; Fischetto, R; Previderé, C; Belli, S; Turci, A; Calabrese, G; Bernardi, F; Meneghelli, E; Riegel, M; Rocchi, M; SGuerneri; Lalatta, F; Zelante, L; Romano, C; Fichera, Ma; Mattina, T; Arrigo, G; Zollino, M; Giglio, S; Lonardo, F; Bonfante, A; Ferlini, A; Cifuentes, F; Van Esch, H; Backx, L; Schinzel, A; Vermeesch, J R; Zuffardi, O

2007-01-01

Using array comparative genome hybridisation (CGH) 41 de novo reciprocal translocations and 18 de novo complex chromosome rearrangements (CCRs) were screened. All cases had been interpreted as “balanced” by conventional cytogenetics. In all, 27 cases of reciprocal translocations were detected in patients with an abnormal phenotype, and after array CGH analysis, 11 were found to be unbalanced. Thus 40% (11 of 27) of patients with a “chromosomal phenotype” and an apparently balanced translocation were in fact unbalanced, and 18% (5 of 27) of the reciprocal translocations were instead complex rearrangements with >3 breakpoints. Fourteen fetuses with de novo, apparently balanced translocations, all but two with normal ultrasound findings, were also analysed and all were found to be normal using array CGH. Thirteen CCRs were detected in patients with abnormal phenotypes, two in women who had experienced repeated spontaneous abortions and three in fetuses. Sixteen patients were found to have unbalanced mutations, with up to 4 deletions. These results suggest that genome‐wide array CGH may be advisable in all carriers of “balanced” CCRs. The parental origin of the deletions was investigated in 5 reciprocal translocations and 11 CCRs; all were found to be paternal. Using customised platforms in seven cases of CCRs, the deletion breakpoints were narrowed down to regions of a few hundred base pairs in length. No susceptibility motifs were associated with the imbalances. These results show that the phenotypic abnormalities of apparently balanced de novo CCRs are mainly due to cryptic deletions and that spermatogenesis is more prone to generate multiple chaotic chromosome imbalances and reciprocal translocations than oogenesis. PMID:17766364

[A survey on the dietary and health habits according to action styles for unbalanced diets among female university students].

PubMed

Nagashima, Kumiko; Sakaguchi, Sanae; Sakaguchi, Takehiro

2002-05-01

A survey of woman's students, who had grown up in a time of change-over of Japanese customs regarding food, was conducted to investigate dietary habits, a focus on actions in response to with set needs, The aim was to obtain to measure prospective health maintenance and promotion. The authors carried out a questionnaire for woman's students in 6 universities of Kanto area (a junior college and graduate courses were included) in years 1999 and 2000. In actions regarding the diet, 19.1% of the 815 students responded "I eat everything without fail", 17.7% "I eat almost everything irrespective of likes and dislikes", 24.5% "I strive to eat everything", 19.8% "I leave almost everything I dislike", and 18.5% "I don't eat what I dislike". The students who responded "I leave almost everything I dislike" and "I don't eat what I dislike" had low scores in the questionnaire for dietary and health habits, and they tended to like noodles and popular snacks, and also made frequent use of fast food restaurants. There was not a problem with the majority, but about 30% of the students were judged as confirming an unbalanced diet by this questionnaire. It was found that there were "gaps" and "bad habits" in the regular diet. Moreover, we recognized a tendency to prefer convenience and taste to nutritional balance. This simple questionnaire is suitable for rapid identification of unbalanced distory habits, and both "gaps" and "bad habits" in the regular system diet. It is the most important that we induce students who leave or don't eat what they dislike, to strive to eat everything, irrespective of likes and dislikes.

Abnormal meiosis in an intersectional allotriploid of Populus L. and segregation of ploidy levels in 2x × 3x progeny

PubMed Central

Huo, Beibei; Liu, Wanting; Li, Daili; Liao, Ling

2017-01-01

Triploid plants are usually highly aborted owing to unbalanced meiotic chromosome segregation, but limited viable gametes can participate in the transition to different ploidy levels. In this study, numerous meiotic abnormalities were found with high frequency in an intersectional allotriploid poplar (Populus alba × P. berolinensis ‘Yinzhong’), including univalents, precocious chromosome migration, lagging chromosomes, chromosome bridges, micronuclei, and precocious cytokinesis, indicating high genetic imbalance in this allotriploid. Some micronuclei trigger mini-spindle formation in metaphase II and participate in cytokinesis to form polyads with microcytes. Unbalanced chromosome segregation and chromosome elimination resulted in the formation of microspores with aneuploid chromosome sets. Fusion of sister nuclei occurs in microsporocytes with precocious cytokinesis, which could form second meiotic division restitution (SDR)-type gametes. However, SDR-type gametes likely contain incomplete chromosome sets due to unbalanced segregation of homologous chromosomes during the first meiotic division in triploids. Misorientation of spindles during the second meiotic division, such as fused and tripolar spindles with low frequency, could result in the formation of first meiotic division restitution (FDR)-type unreduced gametes, which most likely contain three complete chromosome sets. Although ‘Yinzhong’ yields 88.7% stainable pollen grains with wide diameter variation from 23.9 to 61.3 μm, the pollen viability is poor (2.78% ± 0.38). A cross of ‘Yinzhong’ pollen with a diploid female clone produced progeny with extensive segregation of ploidy levels, including 29 diploids, 18 triploids, 4 tetraploids, and 48 aneuploids, suggesting the formation of viable aneuploidy and unreduced pollen in ‘Yinzhong’. Individuals with different chromosome compositions are potential to analyze chromosomal function and to integrate the chromosomal dosage variation into breeding programs of Populus. PMID:28732039

Analysis of messy data with heteroscedastic in mean models

NASA Astrophysics Data System (ADS)

Trianasari, Nurvita; Sumarni, Cucu

2016-02-01

In the analysis of the data, we often faced with the problem of data where the data did not meet some assumptions. In conditions of such data is often called data messy. This problem is a consequence of the data that generates outliers that bias or error estimation. To analyze the data messy, there are three approaches, namely standard analysis, transform data and data analysis methods rather than a standard. Simulations conducted to determine the performance of a third comparative test procedure on average often the model variance is not homogeneous. Data simulation of each scenario is raised as much as 500 times. Next, we do the analysis of the average comparison test using three methods, Welch test, mixed models and Welch-r test. Data generation is done through software R version 3.1.2. Based on simulation results, these three methods can be used for both normal and abnormal case (homoscedastic). The third method works very well on data balanced or unbalanced when there is no violation in the homogenity's assumptions variance. For balanced data, the three methods still showed an excellent performance despite the violation of the assumption of homogeneity of variance, with the requisite degree of heterogeneity is high. It can be shown from the level of power test above 90 percent, and the best to Welch method (98.4%) and the Welch-r method (97.8%). For unbalanced data, Welch method will be very good moderate at in case of heterogeneity positive pair with a 98.2% power. Mixed models method will be very good at case of highly heterogeneity was negative negative pairs with power. Welch-r method works very well in both cases. However, if the level of heterogeneity of variance is very high, the power of all method will decrease especially for mixed models methods. The method which still works well enough (power more than 50%) is Welch-r method (62.6%), and the method of Welch (58.6%) in the case of balanced data. If the data are unbalanced, Welch-r method works well enough in the case of highly heterogeneous positive positive or negative negative pairs, there power are 68.8% and 51% consequencly. Welch method perform well enough only in the case of highly heterogeneous variety of positive positive pairs with it is power of 64.8%. While mixed models method is good in the case of a very heterogeneous variety of negative partner with 54.6% power. So in general, when there is a variance is not homogeneous case, Welch method is applied to the data rank (Welch-r) has a better performance than the other methods.

Current outcomes and risk factors for the Norwood procedure.

PubMed

Stasik, Chad N; Gelehrter, S; Goldberg, Caren S; Bove, Edward L; Devaney, Eric J; Ohye, Richard G

2006-02-01

Tremendous strides have been made in the outcomes for hypoplastic left heart syndrome and other functional single-ventricle malformations over the past 25 years. This progress relates primarily to improvements in survival for patients undergoing the Norwood procedure. Previous reports on risk factors have been on smaller groups of patients or collected over relatively long periods of time, during which management has evolved. We analyzed our current results for the Norwood procedure with attention to risk factors for poor outcome. A single-institution review of all patients undergoing a Norwood procedure for a single-ventricle malformation from May 1, 2001, through April 30, 2003, was performed. Patient demographics, anatomy, clinical condition, associated anomalies, operative details, and outcomes were recorded. Of the 111 patients, there were 23 (21%) hospital deaths. Univariate analysis revealed noncardiac abnormalities (genetic or significant extracardiac diagnosis, P = .0018), gestational age (P = .03), diagnosis of unbalanced atrioventricular septal defect (P = .017), and weight of less than 2.5 kg (P = .0072) to be related to hospital death. On multivariate analysis, only weight of less than 2.5 kg and noncardiac abnormalities were found to be independent risk factors. Patients with either of these characteristics had a hospital survival of 52% (12/23), whereas those at standard risk had a survival of 86% (76/88). Although improvements in management might have lessened the effect of some of the traditionally reported risk factors related to variations in the cardiovascular anatomy, noncardiac abnormalities and low birth weight remain as a future challenge for the physician caring for the patient with single-ventricle physiology.

Comparative study of reference currents and DC bus voltage control for Three-Phase Four-Wire Four-Leg SAPF to compensate harmonics and reactive power with 3D SVM.

PubMed

Chebabhi, A; Fellah, M K; Kessal, A; Benkhoris, M F

2015-07-01

In this paper the performances of three reference currents and DC bus voltage control techniques for Three-Phase Four-Wire Four-Leg SAPF are compared for balanced and unbalanced load conditions. The main goals are to minimize the harmonics, reduce the magnitude of neutral current, eliminate the zero-sequence current components caused by single-phase nonlinear loads and compensate the reactive power, and on the other hand improve performances such as robustness, stabilization, trajectory pursuit, and reduce time response. The three techniques are analyzed mathematically and simulation results are compared. The techniques considered for comparative study are the PI Control, Sliding Mode Control and the Backstepping Control. Synchronous reference frame theory (SRF) in the dqo-axes is used to generate the reference currents, of the inverter. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

Aneuploidy-induced cellular stresses limit autophagic degradation

PubMed Central

Santaguida, Stefano; Vasile, Eliza; White, Eileen; Amon, Angelika

2015-01-01

An unbalanced karyotype, a condition known as aneuploidy, has a profound impact on cellular physiology and is a hallmark of cancer. Aneuploid cells experience a number of stresses that are caused by aneuploidy-induced proteomic changes. How the aneuploidy-associated stresses affect cells and whether cells respond to them are only beginning to be understood. Here we show that autophagosomal cargo such as protein aggregates accumulate within lysosomes in aneuploid cells. This causes a lysosomal stress response. Aneuploid cells activate the transcription factor TFEB, a master regulator of autophagic and lysosomal gene expression, thereby increasing the expression of genes needed for autophagy-mediated protein degradation. Accumulation of autophagic cargo within the lysosome and activation of TFEB-responsive genes are also observed in cells in which proteasome function is inhibited, suggesting that proteotoxic stress causes TFEB activation. Our results reveal a TFEB-mediated lysosomal stress response as a universal feature of the aneuploid state. PMID:26404941

Dynamics of non-holonomic systems with stochastic transport

NASA Astrophysics Data System (ADS)

Holm, D. D.; Putkaradze, V.

2018-01-01

This paper formulates a variational approach for treating observational uncertainty and/or computational model errors as stochastic transport in dynamical systems governed by action principles under non-holonomic constraints. For this purpose, we derive, analyse and numerically study the example of an unbalanced spherical ball rolling under gravity along a stochastic path. Our approach uses the Hamilton-Pontryagin variational principle, constrained by a stochastic rolling condition, which we show is equivalent to the corresponding stochastic Lagrange-d'Alembert principle. In the example of the rolling ball, the stochasticity represents uncertainty in the observation and/or error in the computational simulation of the angular velocity of rolling. The influence of the stochasticity on the deterministically conserved quantities is investigated both analytically and numerically. Our approach applies to a wide variety of stochastic, non-holonomically constrained systems, because it preserves the mathematical properties inherited from the variational principle.

Combining MLC and SVM Classifiers for Learning Based Decision Making: Analysis and Evaluations

PubMed Central

Zhang, Yi; Ren, Jinchang; Jiang, Jianmin

2015-01-01

Maximum likelihood classifier (MLC) and support vector machines (SVM) are two commonly used approaches in machine learning. MLC is based on Bayesian theory in estimating parameters of a probabilistic model, whilst SVM is an optimization based nonparametric method in this context. Recently, it is found that SVM in some cases is equivalent to MLC in probabilistically modeling the learning process. In this paper, MLC and SVM are combined in learning and classification, which helps to yield probabilistic output for SVM and facilitate soft decision making. In total four groups of data are used for evaluations, covering sonar, vehicle, breast cancer, and DNA sequences. The data samples are characterized in terms of Gaussian/non-Gaussian distributed and balanced/unbalanced samples which are then further used for performance assessment in comparing the SVM and the combined SVM-MLC classifier. Interesting results are reported to indicate how the combined classifier may work under various conditions. PMID:26089862

Combining MLC and SVM Classifiers for Learning Based Decision Making: Analysis and Evaluations.

PubMed

Zhang, Yi; Ren, Jinchang; Jiang, Jianmin

2015-01-01

Maximum likelihood classifier (MLC) and support vector machines (SVM) are two commonly used approaches in machine learning. MLC is based on Bayesian theory in estimating parameters of a probabilistic model, whilst SVM is an optimization based nonparametric method in this context. Recently, it is found that SVM in some cases is equivalent to MLC in probabilistically modeling the learning process. In this paper, MLC and SVM are combined in learning and classification, which helps to yield probabilistic output for SVM and facilitate soft decision making. In total four groups of data are used for evaluations, covering sonar, vehicle, breast cancer, and DNA sequences. The data samples are characterized in terms of Gaussian/non-Gaussian distributed and balanced/unbalanced samples which are then further used for performance assessment in comparing the SVM and the combined SVM-MLC classifier. Interesting results are reported to indicate how the combined classifier may work under various conditions.

The Impact of Transformer Winding Connections of A Grid-Connected PV on Voltage Quality Improvement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muljadi, Eduard; Tumbelaka, Hanny H.; Gao, Wenzhong

In this paper, the high-power PV plant is connected to the weak grid by means of a three-phase power transformer. The selection of transformer winding connection is critical especially when the PV inverter has a reactive power controller. In general, transformer winding connection can be arranged in star-star (with neutral earthed) or star-delta. The reactive power controller supports voltage regulation of the power system particularly under transient faults. Its control strategy is based on utilizing the grid currents to make a three-phase reactive unbalanced current with a small gain. The gain is determined by the system impedance. Simulation results exhibitmore » that the control strategy works very well particularly under disturbance conditions when the transformer winding connection is star-star with both neutrals grounded. The power quality in terms of the voltage quality is improved.« less

An improved risk-explicit interval linear programming model for pollution load allocation for watershed management.

PubMed

Xia, Bisheng; Qian, Xin; Yao, Hong

2017-11-01

Although the risk-explicit interval linear programming (REILP) model has solved the problem of having interval solutions, it has an equity problem, which can lead to unbalanced allocation between different decision variables. Therefore, an improved REILP model is proposed. This model adds an equity objective function and three constraint conditions to overcome this equity problem. In this case, pollution reduction is in proportion to pollutant load, which supports balanced development between different regional economies. The model is used to solve the problem of pollution load allocation in a small transboundary watershed. Compared with the REILP original model result, our model achieves equity between the upstream and downstream pollutant loads; it also overcomes the problem of greatest pollution reduction, where sources are nearest to the control section. The model provides a better solution to the problem of pollution load allocation than previous versions.

A magnetostrictive composite-fiber Bragg Grating sensor.

PubMed

Quintero, Sully M M; Braga, Arthur M B; Weber, Hans I; Bruno, Antonio C; Araújo, Jefferson F D F

2010-01-01

This paper presents a light and compact optical fiber Bragg Grating sensor for DC and AC magnetic field measurements. The fiber is coated by a thick layer of a magnetostrictive composite consisting of particles of Terfenol-D dispersed in a polymeric matrix. Among the different compositions for the coating that were tested, the best magnetostrictive response was obtained using an epoxy resin as binder and a 30% volume fraction of Terfenol-D particles with sizes ranging from 212 to 300 μm. The effect of a compressive preload in the sensor was also investigated. The achieved resolution was 0.4 mT without a preload or 0.3 mT with a compressive pre-stress of 8.6 MPa. The sensor was tested at magnetic fields of up to 750 mT under static conditions. Dynamic measurements were conducted with a magnetic unbalanced four-pole rotor.

A Magnetostrictive Composite-Fiber Bragg Grating Sensor

PubMed Central

Quintero, Sully M. M.; Braga, Arthur M. B.; Weber, Hans I.; Bruno, Antonio C.; Araújo, Jefferson F. D. F.

2010-01-01

This paper presents a light and compact optical fiber Bragg Grating sensor for DC and AC magnetic field measurements. The fiber is coated by a thick layer of a magnetostrictive composite consisting of particles of Terfenol-D dispersed in a polymeric matrix. Among the different compositions for the coating that were tested, the best magnetostrictive response was obtained using an epoxy resin as binder and a 30% volume fraction of Terfenol-D particles with sizes ranging from 212 to 300 μm. The effect of a compressive preload in the sensor was also investigated. The achieved resolution was 0.4 mT without a preload or 0.3 mT with a compressive pre-stress of 8.6 MPa. The sensor was tested at magnetic fields of up to 750 mT under static conditions. Dynamic measurements were conducted with a magnetic unbalanced four-pole rotor. PMID:22163644

A D-vine copula-based model for repeated measurements extending linear mixed models with homogeneous correlation structure.

PubMed

Killiches, Matthias; Czado, Claudia

2018-03-22

We propose a model for unbalanced longitudinal data, where the univariate margins can be selected arbitrarily and the dependence structure is described with the help of a D-vine copula. We show that our approach is an extremely flexible extension of the widely used linear mixed model if the correlation is homogeneous over the considered individuals. As an alternative to joint maximum-likelihood a sequential estimation approach for the D-vine copula is provided and validated in a simulation study. The model can handle missing values without being forced to discard data. Since conditional distributions are known analytically, we easily make predictions for future events. For model selection, we adjust the Bayesian information criterion to our situation. In an application to heart surgery data our model performs clearly better than competing linear mixed models. © 2018, The International Biometric Society.

Statistical analysis of Skylab 3. [endocrine/metabolic studies of astronauts

NASA Technical Reports Server (NTRS)

Johnston, D. A.

1974-01-01

The results of endocrine/metabolic studies of astronauts on Skylab 3 are reported. One-way analysis of variance, contrasts, two-way unbalanced analysis of variance, and analysis of periodic changes in flight are included. Results for blood tests, and urine tests are presented.

Intergenerational Effects of Incest on Parenting: Skills, Abilities, and Attitudes.

ERIC Educational Resources Information Center

Armsworth, Mary W.; Stronck, Karin

1999-01-01

Investigates women's perceptions of generational influences of incest on their skills, abilities, and attitudes toward parenting their own children. Overarching themes that emerged were classified as unbalanced development, disconnected lives, and disowned dramas. Implications for clinical intervention, parent training, and future research are…

48 CFR 852.273-72 - Alternative evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Alternative evaluation... Alternative evaluation. As prescribed in 873.110(c), insert the following provision: Alternative Evaluation... unbalanced. Evaluation of options shall not obligate the Government to exercise the option(s). (End of...

φ-OTDR sensing system with bidirectional pumped fiber Raman amplifier and unbalanced MZ interferometer

NASA Astrophysics Data System (ADS)

Zhang, Liang; Tian, Ming; Dong, Lei

2017-10-01

In order to improve the detection distance and the sensitivity, we propose a novel distributed optical fiber sensing system. This system is composed of bidirectional pumping fiber Raman amplifier and unbalanced fiber Mach-Zehnder interferometer. Based on the interference mechanism of phase sensitive optical time domain reflectometer (φ-OTDR), the system can get the sensing information of the whole optical fiber by analyzing the backward scattered light. The interferometer is used as the demodulator of the sensing system, which consists of a 3×3 coupler and two faraday rotator mirrors. By means of the demodulator, the signal light is divided into three beams with fixed phase difference. To deal with these three signals, we can get the vibration information directly on the optical fiber. Through experimental study, this system has a high sensitivity. The maximum sensing length and the spatial resolution of the φ-OTDR system are 100 km and 10 m. The signal to noise ratio about 18 dB is achieved.

A Modular PV System Using Chain-Link-Type Multilevel Converter

NASA Astrophysics Data System (ADS)

Hatano, Nobuhiko; Ise, Toshifumi

This paper presents a modular photovoltaic system (MPVS) that uses a chain-link-type multilevel converter (CLMC). In large-scale PV generating systems, the DC power supply is generally composed of a large number of PV panels. Hence, losses are caused by differences in the maximum power point at each PV panel. An MPVS has been proposed to address the above mentioned problem. It helps improve the photoelectric conversion efficiency by applying maximum power point tracking (MPPT) control to each group of PV panels. In addition, if a CLMC is used in an MPVS, a high voltage can be output from the AC side and transmission losses can be decreased. However, with this circuit configuration, the current output from the AC side may be unbalanced. Therefore, we propose a method to output balanced current from the AC side, even if the output of the DC power supply is unbalanced. The validity of the proposed method is examined by digital simulation.

Sparse Coding and Lateral Inhibition Arising from Balanced and Unbalanced Dendrodendritic Excitation and Inhibition

PubMed Central

Migliore, Michele; Hines, Michael L.; Shepherd, Gordon M.

2014-01-01

The precise mechanism by which synaptic excitation and inhibition interact with each other in odor coding through the unique dendrodendritic synaptic microcircuits present in olfactory bulb is unknown. Here a scaled-up model of the mitral–granule cell network in the rodent olfactory bulb is used to analyze dendrodendritic processing of experimentally determined odor patterns. We found that the interaction between excitation and inhibition is responsible for two fundamental computational mechanisms: (1) a balanced excitation/inhibition in strongly activated mitral cells, leading to a sparse representation of odorant input, and (2) an unbalanced excitation/inhibition (inhibition dominated) in surrounding weakly activated mitral cells, leading to lateral inhibition. These results suggest how both mechanisms can carry information about the input patterns, with optimal level of synaptic excitation and inhibition producing the highest level of sparseness and decorrelation in the network response. The results suggest how the learning process, through the emergent development of these mechanisms, can enhance odor representation of olfactory bulb. PMID:25297097

Modular Cascaded H-Bridge Multilevel PV Inverter with Distributed MPPT for Grid-Connected Applications

DOE PAGES

Xiao, Bailu; Hang, Lijun; Mei, Jun; ...

2014-09-04

This paper presents a modular cascaded H-bridge multilevel photovoltaic (PV) inverter for single- or three-phase grid-connected applications. The modular cascaded multilevel topology helps to improve the efficiency and flexibility of PV systems. To realize better utilization of PV modules and maximize the solar energy extraction, a distributed maximum power point tracking (MPPT) control scheme is applied to both single-phase and three-phase multilevel inverters, which allows the independent control of each dc-link voltage. For three-phase grid-connected applications, PV mismatches may introduce unbalanced supplied power, leading to unbalanced grid current. To solve this issue, a control scheme with modulation compensation is alsomore » proposed. An experimental three-phase 7-level cascaded H-bridge inverter has been built utilizing 9 H-bridge modules (3 modules per phase). Each H-bridge module is connected to a 185 W solar panel. Simulation and experimental results are presented to verify the feasibility of the proposed approach.« less

Estimation of the linear mixed integrated Ornstein–Uhlenbeck model

PubMed Central

Hughes, Rachael A.; Kenward, Michael G.; Sterne, Jonathan A. C.; Tilling, Kate

2017-01-01

ABSTRACT The linear mixed model with an added integrated Ornstein–Uhlenbeck (IOU) process (linear mixed IOU model) allows for serial correlation and estimation of the degree of derivative tracking. It is rarely used, partly due to the lack of available software. We implemented the linear mixed IOU model in Stata and using simulations we assessed the feasibility of fitting the model by restricted maximum likelihood when applied to balanced and unbalanced data. We compared different (1) optimization algorithms, (2) parameterizations of the IOU process, (3) data structures and (4) random-effects structures. Fitting the model was practical and feasible when applied to large and moderately sized balanced datasets (20,000 and 500 observations), and large unbalanced datasets with (non-informative) dropout and intermittent missingness. Analysis of a real dataset showed that the linear mixed IOU model was a better fit to the data than the standard linear mixed model (i.e. independent within-subject errors with constant variance). PMID:28515536

Coordinated single-phase control scheme for voltage unbalance reduction in low voltage network.

PubMed

Pullaguram, Deepak; Mishra, Sukumar; Senroy, Nilanjan

2017-08-13

Low voltage (LV) distribution systems are typically unbalanced in nature due to unbalanced loading and unsymmetrical line configuration. This situation is further aggravated by single-phase power injections. A coordinated control scheme is proposed for single-phase sources, to reduce voltage unbalance. A consensus-based coordination is achieved using a multi-agent system, where each agent estimates the averaged global voltage and current magnitudes of individual phases in the LV network. These estimated values are used to modify the reference power of individual single-phase sources, to ensure system-wide balanced voltages and proper power sharing among sources connected to the same phase. Further, the high X / R ratio of the filter, used in the inverter of the single-phase source, enables control of reactive power, to minimize voltage unbalance locally. The proposed scheme is validated by simulating a LV distribution network with multiple single-phase sources subjected to various perturbations.This article is part of the themed issue 'Energy management: flexibility, risk and optimization'. © 2017 The Author(s).

Efficient Delaunay Tessellation through K-D Tree Decomposition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morozov, Dmitriy; Peterka, Tom

Delaunay tessellations are fundamental data structures in computational geometry. They are important in data analysis, where they can represent the geometry of a point set or approximate its density. The algorithms for computing these tessellations at scale perform poorly when the input data is unbalanced. We investigate the use of k-d trees to evenly distribute points among processes and compare two strategies for picking split points between domain regions. Because resulting point distributions no longer satisfy the assumptions of existing parallel Delaunay algorithms, we develop a new parallel algorithm that adapts to its input and prove its correctness. We evaluatemore » the new algorithm using two late-stage cosmology datasets. The new running times are up to 50 times faster using k-d tree compared with regular grid decomposition. Moreover, in the unbalanced data sets, decomposing the domain into a k-d tree is up to five times faster than decomposing it into a regular grid.« less

L2-L1 Translation Priming Effects in a Lexical Decision Task: Evidence From Low Proficient Korean-English Bilinguals

PubMed Central

Lee, Yoonhyoung; Jang, Euna; Choi, Wonil

2018-01-01

One of the key issues in bilingual lexical representation is whether L1 processing is facilitated by L2 words. In this study, we conducted two experiments using the masked priming paradigm to examine how L2-L1 translation priming effects emerge when unbalanced, low proficiency, Korean-English bilinguals performed a lexical decision task. In Experiment 1, we used a 150 ms SOA (50 ms prime duration followed by a blank interval of 100 ms) and found a significant L2-L1 translation priming effect. In contrast, in Experiment 2, we used a 60 ms SOA (50 ms prime duration followed by a blank interval of 10 ms) and found a null effect of L2-L1 translation priming. This finding is the first demonstration of a significant L2-L1 translation priming effect with unbalanced Korean-English bilinguals. Implications of this work are discussed with regard to bilingual word recognition models. PMID:29599733

Monochromatic X-ray-induced thermal effect on four-reflection “nested” meV-monochromators: dynamical diffraction theory and finite-element analysis

NASA Astrophysics Data System (ADS)

Hu, Ling-Fei; Gao, Li-Dan; Li, Zhen-Jie; Wang, Shan-Feng; Sheng, Wei-Fan; Liu, Peng; Xu, Wei

2015-09-01

The high energy resolution monochromator (HRM) is widely used in inelastic scattering programs to detect phonons with energy resolution, down to the meV level. Although the large amount of heat from insertion devices can be reduced by a high heat-load monochromator, the unbalanced heat load on the inner pair of crystals in a nested HRM can affect its overall performance. Here, a theoretical analysis of the unbalanced heat load using dynamical diffraction theory and finite element analysis is presented. By utilizing the ray-tracing method, the performance of different HRM nesting configurations is simulated. It is suggested that the heat balance ratio, energy resolution, and overall spectral transmission efficiency are the figures of merit for evaluating the performance of nested HRMs. Although the present study is mainly focused on nested HRMs working at 57Fe nuclear resonant energy at 14.4 keV, it is feasible to extend this to other nested HRMs working at different energies.

Heavy and Overweight Vehicle Brake Testing: Five-Axle Combination Tractor-Flatbed Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lascurain, Mary Beth; Capps, Gary J; Franzese, Oscar

The Federal Motor Carrier Safety Administration, in coordination with the Federal Highway Administration, sponsored the Heavy and Overweight Vehicle Brake Testing (HOVBT) program in order to provide information about the effect of gross vehicle weight (GVW) on braking performance. Because the Federal Motor Carrier Safety Regulations limit the number of braking system defects that may exist for a vehicle to be allowed to operate on the roadways, the examination of the effect of brake defects on brake performance for increased loads is also relevant. The HOVBT program seeks to provide relevant information to policy makers responsible for establishing load limits,more » beginning with providing test data for a combination tractor/trailer. This testing was conducted on a five-axle combination vehicle with tractor brakes meeting the Reduced Stopping Distance requirement rulemaking. This report provides a summary of the testing activities, the results of various analyses of the data, and recommendations for future research. Following a complete brake rebuild, instrumentation, and brake burnish, stopping tests were performed from 20 and 40 mph with various brake application pressures (15 psi, 25 psi, 35 psi, 45 psi, 55 psi, and full system pressure). These tests were conducted for various brake conditions at the following GVWs: 60,000, 80,000, 91,000, 97,000, 106,000, and 116,000 lb. The 80,000-lb GVWs included both balanced and unbalanced loads. The condition of the braking system was also varied. To introduce these defects, brakes (none, forward drive axle, or rear trailer axle) were made inoperative. In addition to the stopping tests, performance-based brake tests were conducted for the various loading and brake conditions. Analysis of the stopping test data showed the stopping distance to increase with load (as expected) and also showed that more braking force was generated by the drive axle brakes than the trailer axle brakes. The constant-pressure stopping test data revealed a linear relationship between brake application pressure and was used to develop an algorithm to normalize stopping data for weight and initial speed.« less

Burnout: Interpreting the Perception of Iranian Primary Rural Health Care Providers from Working and Organizational Conditions

PubMed Central

Keshvari, Mahrokh; Mohammadi, Eesa; Boroujeni, Ali Zargham; Farajzadegan, Ziba

2012-01-01

Objectives: Health care providers in the rural centers offer the primary health services in the form of proficiencies and professions to the most required target population in the health system. These services are provided in certain condition and population with a verity of limitations. This study aimed to describe and interpret the experiences of the employees from their own working condition in the rural health centers. Methods: The present study conducted in a qualitative research approach and content analysis method through individual and group interviews with 26 employed primary health care providers (including 7 family physicians, 7 midwives, and 12 health workers) in the rural health centers in Isfahan in 2009. Sampling was done using purposive sampling method. The data were analyzed using qualitative content analysis as constant comparative basis. Results: During the content analysis process, six themes were obtained; “instability and frequent changes”, “involved in laws and regulations”, “pressure and stress due to unbalanced workload and manpower”, “helplessness in performing the tasks and duties”, “sense of identity threat and low self-concept”, and “deprivation of professional development”. The mentioned themes indicate a main and more important theme called “burnout”. Conclusions: Health services providers in the rural health centers are working in stressful and challenging work conditions and are suffered from deprivation of something for which are responsible to the community. PMID:22826774

Profiles in Bilingualism: Factors Influencing Kindergartners' Language Proficiency

ERIC Educational Resources Information Center

Dixon, L. Quentin; Wu, Shuang; Daraghmeh, Ahlam

2012-01-01

Three common assumptions concerning bilingual children's language proficiency are: (1) their proficiency in two languages is usually unbalanced; (2) low socioeconomic status (SES) indicates low proficiency in both languages; and (3) encouraging parents to speak some societal language at home will promote its development. Examining the vocabulary…

Disturbance dynamics and ecosystem-based forest management

Treesearch

Kalev Jogiste; W. Keith Moser; Malle Mandre

2005-01-01

Ecosystem-based management is intended to balance ecological, social and economic values of sustainable resource management. The desired future state of forest ecosystem is usually defined through productivity, biodiversity, stability or other terms. However, ecosystem-based management may produce an unbalanced emphasis on different components. Although ecosystem-based...

Meeting the Social Emotional Needs of Gifted Adolescents: A Personal and Contextual Journey.

ERIC Educational Resources Information Center

Strop, Jean

2002-01-01

This article considers both the intrapersonal and interpersonal issues that have historically caused difficulty for groups of gifted students, including self-knowledge and self-acceptance, irrational beliefs, need for independence, heightened sensitivity, frustration tolerance, unbalanced value, and tolerating others. Interventions are provided…

29 CFR 1926.955 - Overhead lines.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED... unbalanced stresses to which they will be subjected. (3) Where poles or structures may be unsafe for climbing..., except in bare-hand live-line work, or where barriers or protective devices are used. (ii) Equipment and...

29 CFR 1926.955 - Overhead lines.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED... unbalanced stresses to which they will be subjected. (3) Where poles or structures may be unsafe for climbing..., except in bare-hand live-line work, or where barriers or protective devices are used. (ii) Equipment and...

29 CFR 1926.955 - Overhead lines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED... unbalanced stresses to which they will be subjected. (3) Where poles or structures may be unsafe for climbing..., except in bare-hand live-line work, or where barriers or protective devices are used. (ii) Equipment and...

29 CFR 1926.955 - Overhead lines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED... unbalanced stresses to which they will be subjected. (3) Where poles or structures may be unsafe for climbing..., except in bare-hand live-line work, or where barriers or protective devices are used. (ii) Equipment and...

29 CFR 1926.955 - Overhead lines.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED... unbalanced stresses to which they will be subjected. (3) Where poles or structures may be unsafe for climbing..., except in bare-hand live-line work, or where barriers or protective devices are used. (ii) Equipment and...

Let Them Eat More Than Phonics.

ERIC Educational Resources Information Center

Zimmermann, Jerry; Brown, Carolyn

2003-01-01

Uses reading-guide pyramid based on U.S. Department of Agriculture's food-guide pyramid to develop argument that new federal guidelines for scientific-based research will result in an unbalanced, phonics-rich approach to reading instruction. Argues for a balanced approach that includes comprehension, vocabulary, fluency, and phonics. (PKP)

Restructuring Schools To Be Math Friendly to Females.

ERIC Educational Resources Information Center

Karp, Karen; Shakeshaft, Charol

1997-01-01

The gender gap in math Scholastic Aptitude Test scores, attributable to course avoidance, lack of confidence, and unbalanced classroom instruction, can have serious consequences for young women, such as limited university selection, limited career choices, and lower lifetime salaries. Solutions include hiring math specialists, establishing role…

Teddy's Story

ERIC Educational Resources Information Center

Bedrossian, Laura

2008-01-01

Eighteen years ago, the author's son Teddy was born with an unbalanced chromosome translocation of 10/12, leaving him with severe disabilities, medically fragile, and chronically ill. The author describes how her entire world was changed that day. Through it all, her journey through life has been an extraordinary educational experience, despite…

Does unbalanced gender composition in the workplace influence the association between psychosocial working conditions and sickness absence?

PubMed

Jonsson, Robin; Lidwall, Ulrik; Holmgren, Kristina

2013-01-01

Earlier research has shown that bad psychosocial working conditions contribute to sick-leave. Some theorists argue that skewed gender composition can be one of the factors contributing to bad psychosocial working conditions. We examine whether workplace gender composition has an effect on the association between job strain and sick-leave. Associations were assessed using a case-control study with Swedish data collected in 2008 (n=5595). Results indicated that there was an association between high strain jobs and sickness absence among both women (Adj. OR 2.04, CI95% 1.62-2.57) and men (2.24, 1.67-3.01). Furthermore, both women (2.87, 1.34-6.26) and men (2.53, 1.74-3.69) in male-dominated workplaces had the highest risk for sickness absence due to high strain jobs. Male-dominated workplaces were, in general adverse for both women and men. The results indicated that a minority position strengthens job strain for women while it weakens the association for men. Using modern gender theories, we could argue that some of these results might be explained by the general use of masculinity as the social norm in the labor market. However, findings from this study need to be validated by further research.

The Implementation Internet of Things(IoT) Technology in Real Time Monitoring of Electrical Quantities

NASA Astrophysics Data System (ADS)

Despa, D.; Nama, G. F.; Muhammad, M. A.; Anwar, K.

2018-04-01

Electrical quantities such as Voltage, Current, Power, Power Factor, Energy, and Frequency in electrical power system tends to fluctuate, as a result of load changes, disturbances, or other abnormal states. The change-state in electrical quantities should be identify immediately, otherwise it can lead to serious problem for whole system. Therefore a necessity is required to determine the condition of electricity change-state quickly and appropriately in order to make effective decisions. Online monitoring of power distribution system based on Internet of Things (IoT) technology was deploy and implemented on Department of Mechanical Engineering University of Lampung (Unila), especially at three-phase main distribution panel H-building. The measurement system involve multiple sensors such current sensors and voltage sensors, while data processing conducted by Arduino, the measurement data stored in to the database server and shown in a real-time through a web-based application. This measurement system has several important features especially for realtime monitoring, robust data acquisition and logging, system reporting, so it will produce an important information that can be used for various purposes of future power analysis such estimation and planning. The result of this research shown that the condition of electrical power system at H-building performed unbalanced load, which often leads to drop-voltage condition

Charging Guidance of Electric Taxis Based on Adaptive Particle Swarm Optimization

PubMed Central

Niu, Liyong; Zhang, Di

2015-01-01

Electric taxis are playing an important role in the application of electric vehicles. The actual operational data of electric taxis in Shenzhen, China, is analyzed, and, in allusion to the unbalanced time availability of the charging station equipment, the electric taxis charging guidance system is proposed basing on the charging station information and vehicle information. An electric taxis charging guidance model is established and guides the charging based on the positions of taxis and charging stations with adaptive mutation particle swarm optimization. The simulation is based on the actual data of Shenzhen charging stations, and the results show that electric taxis can be evenly distributed to the appropriate charging stations according to the charging pile numbers in charging stations after the charging guidance. The even distribution among the charging stations in the area will be achieved and the utilization of charging equipment will be improved, so the proposed charging guidance method is verified to be feasible. The improved utilization of charging equipment can save public charging infrastructure resources greatly. PMID:26236770

Flow on the symmetry plane of a total cavo-pulmonary connection.

PubMed

Bolzon, G; Pedrizzetti, G; Grigioni, M; Zovatto, L; Daniele, C; D'Avenio, G

2002-05-01

The flow inside a total cavo-pulmonary connection, a bypass operation of the right heart adopted in the presence of congenital malformation, is here studied for a specific geometry which has been recently introduced in clinics. The analysis has been performed by preliminary experimental observation and a novel Navier-Stokes formulation on the symmetry plane. This method, once some basic hypotheses are verified, allows to reproduce the flow on the symmetry plane of a three-dimensional field by using an extension of the two-dimensional approach. The analysis has confirmed the existence of a central vortex showing that it is not a real vortex (i.e. a place with accumulation of vorticity) but, rather, a weakly dissipative recirculating zone. It is surrounded by a shear layer that becomes spontaneously unsteady at moderately high Reynolds number. The topological changes and energy dissipation have been analysed in both cases of unbalanced and of balanced pulmonary artery and caval flows.

Assessment of Power Quality based on Fuzzy Logic and Discrete Wavelet Transform for Nonstationary Disturbances

NASA Astrophysics Data System (ADS)

Sinha, Pampa; Nath, Sudipta

2010-10-01

The main aspects of power system delivery are reliability and quality. If all the customers of a power system get uninterrupted power through the year then the system is considered to be reliable. The term power quality may be referred to as maintaining near sinusoidal voltage at rated frequency at the consumers end. The power component definitions are defined according to the IEEE Standard 1459-2000 both for single phase and three phase unbalanced systems based on Fourier Transform (FFT). In the presence of nonstationary power quality (PQ) disturbances results in accurate values due to its sensitivity to the spectral leakage problem. To overcome these limitations the power quality components are calculated using Discrete Wavelet Transform (DWT). In order to handle the uncertainties associated with electric power systems operations fuzzy logic has been incorporated in this paper. A new power quality index has been introduced here which can assess the power quality under nonstationary disturbances.

Modern rotor balancing - Emerging technologies

NASA Technical Reports Server (NTRS)

Zorzi, E. S.; Von Pragenau, G. L.

1985-01-01

Modern balancing methods for flexible and rigid rotors are explored. Rigid rotor balancing is performed at several hundred rpm, well below the first bending mode of the shaft. High speed balancing is necessary when the nominal rotational speed is higher than the first bending mode. Both methods introduce weights which will produce rotor responses at given speeds that will be exactly out of phase with the responses of an unbalanced rotor. Modal balancing seeks to add weights which will leave other rotor modes unaffected. Also, influence coefficients can be determined by trial and error addition of weights and recording of their effects on vibration at speeds of interest. The latter method is useful for balancing rotors at other than critical speeds and for performing unified balancing beginning with the first critical speed. Finally, low-speed flexible balancing permits low-speed tests and adjustments of rotor assemblies which will not be accessible when operating in their high-speed functional configuration. The method was developed for the high pressure liquid oxygen turbopumps for the Shuttle.

Space shuttle Ku-band integrated rendezvous radar/communications system study

NASA Technical Reports Server (NTRS)

1976-01-01

The results are presented of work performed on the Space Shuttle Ku-Band Integrated Rendezvous Radar/Communications System Study. The recommendations and conclusions are included as well as the details explaining the results. The requirements upon which the study was based are presented along with the predicted performance of the recommended system configuration. In addition, shuttle orbiter vehicle constraints (e.g., size, weight, power, stowage space) are discussed. The tradeoffs considered and the operation of the recommended configuration are described for an optimized, integrated Ku-band radar/communications system. Basic system tradeoffs, communication design, radar design, antenna tradeoffs, antenna gimbal and drive design, antenna servo design, and deployed assembly packaging design are discussed. The communications and radar performance analyses necessary to support the system design effort are presented. Detailed derivations of the communications thermal noise error, the radar range, range rate, and angle tracking errors, and the communications transmitter distortion parameter effect on crosstalk between the unbalanced quadriphase signals are included.

Charging Guidance of Electric Taxis Based on Adaptive Particle Swarm Optimization.

PubMed

Niu, Liyong; Zhang, Di

2015-01-01

Electric taxis are playing an important role in the application of electric vehicles. The actual operational data of electric taxis in Shenzhen, China, is analyzed, and, in allusion to the unbalanced time availability of the charging station equipment, the electric taxis charging guidance system is proposed basing on the charging station information and vehicle information. An electric taxis charging guidance model is established and guides the charging based on the positions of taxis and charging stations with adaptive mutation particle swarm optimization. The simulation is based on the actual data of Shenzhen charging stations, and the results show that electric taxis can be evenly distributed to the appropriate charging stations according to the charging pile numbers in charging stations after the charging guidance. The even distribution among the charging stations in the area will be achieved and the utilization of charging equipment will be improved, so the proposed charging guidance method is verified to be feasible. The improved utilization of charging equipment can save public charging infrastructure resources greatly.

Unbalance vibration suppression for AMBs system using adaptive notch filter

NASA Astrophysics Data System (ADS)

Chen, Qi; Liu, Gang; Han, Bangcheng

2017-09-01

The unbalance of rotor levitated by active magnetic bearings (AMBs) will cause synchronous vibration which greatly degrade the performance at high speeds in the rotating machinery. To suppress the unbalance vibration without angular velocity information, a novel modified adaptive notch filter (ANF) with phase shift in the AMBs system is presented in this study. Firstly, a 4-degree-of-freedom (DOF) radial unbalanced AMB rotor system is described and analyzed, and the solution of rotor vibration displacement is compared with the experimental data to verify the preciseness of the dynamic model. Then the principle and structure of the proposed notch filter used for the frequency estimation and online identification of synchronous component are presented. As well, the convergence property of the algorithm is investigated. In addition, the stability analysis of the closed-loop AMB system with the proposed ANF is conducted. Simulation and experiments on an AMB driveline system demonstrate the effectiveness and the adaptive characteristics of the proposed ANF on the elimination of synchronous controlled current in a widely operating speed range.

Application of random effects to the study of resource selection by animals

USGS Publications Warehouse

Gillies, C.S.; Hebblewhite, M.; Nielsen, S.E.; Krawchuk, M.A.; Aldridge, Cameron L.; Frair, J.L.; Saher, D.J.; Stevens, C.E.; Jerde, C.L.

2006-01-01

1. Resource selection estimated by logistic regression is used increasingly in studies to identify critical resources for animal populations and to predict species occurrence.2. Most frequently, individual animals are monitored and pooled to estimate population-level effects without regard to group or individual-level variation. Pooling assumes that both observations and their errors are independent, and resource selection is constant given individual variation in resource availability.3. Although researchers have identified ways to minimize autocorrelation, variation between individuals caused by differences in selection or available resources, including functional responses in resource selection, have not been well addressed.4. Here we review random-effects models and their application to resource selection modelling to overcome these common limitations. We present a simple case study of an analysis of resource selection by grizzly bears in the foothills of the Canadian Rocky Mountains with and without random effects.5. Both categorical and continuous variables in the grizzly bear model differed in interpretation, both in statistical significance and coefficient sign, depending on how a random effect was included. We used a simulation approach to clarify the application of random effects under three common situations for telemetry studies: (a) discrepancies in sample sizes among individuals; (b) differences among individuals in selection where availability is constant; and (c) differences in availability with and without a functional response in resource selection.6. We found that random intercepts accounted for unbalanced sample designs, and models with random intercepts and coefficients improved model fit given the variation in selection among individuals and functional responses in selection. Our empirical example and simulations demonstrate how including random effects in resource selection models can aid interpretation and address difficult assumptions limiting their generality. This approach will allow researchers to appropriately estimate marginal (population) and conditional (individual) responses, and account for complex grouping, unbalanced sample designs and autocorrelation.

Application of random effects to the study of resource selection by animals.

PubMed

Gillies, Cameron S; Hebblewhite, Mark; Nielsen, Scott E; Krawchuk, Meg A; Aldridge, Cameron L; Frair, Jacqueline L; Saher, D Joanne; Stevens, Cameron E; Jerde, Christopher L

2006-07-01

1. Resource selection estimated by logistic regression is used increasingly in studies to identify critical resources for animal populations and to predict species occurrence. 2. Most frequently, individual animals are monitored and pooled to estimate population-level effects without regard to group or individual-level variation. Pooling assumes that both observations and their errors are independent, and resource selection is constant given individual variation in resource availability. 3. Although researchers have identified ways to minimize autocorrelation, variation between individuals caused by differences in selection or available resources, including functional responses in resource selection, have not been well addressed. 4. Here we review random-effects models and their application to resource selection modelling to overcome these common limitations. We present a simple case study of an analysis of resource selection by grizzly bears in the foothills of the Canadian Rocky Mountains with and without random effects. 5. Both categorical and continuous variables in the grizzly bear model differed in interpretation, both in statistical significance and coefficient sign, depending on how a random effect was included. We used a simulation approach to clarify the application of random effects under three common situations for telemetry studies: (a) discrepancies in sample sizes among individuals; (b) differences among individuals in selection where availability is constant; and (c) differences in availability with and without a functional response in resource selection. 6. We found that random intercepts accounted for unbalanced sample designs, and models with random intercepts and coefficients improved model fit given the variation in selection among individuals and functional responses in selection. Our empirical example and simulations demonstrate how including random effects in resource selection models can aid interpretation and address difficult assumptions limiting their generality. This approach will allow researchers to appropriately estimate marginal (population) and conditional (individual) responses, and account for complex grouping, unbalanced sample designs and autocorrelation.

Submultiple Data Collection to Explore Spectroscopic Instrument Instabilities Shows that Much of the "Noise" is not Stochastic.

PubMed

Meuse, Curtis W; Filliben, James J; Rubinson, Kenneth A

2018-04-17

As has long been understood, the noise on a spectrometric signal can be reduced by averaging over time, and the averaged noise is expected to decrease as t 1/2 , the square root of the data collection time. However, with contemporary capability for fast data collection and storage, we can retain and access a great deal more information about a signal train than just its average over time. During the same collection time, we can record the signal averaged over much shorter, equal, fixed periods. This is, then, the set of signals over submultiples of the total collection time. With a sufficiently large set of submultiples, the distribution of the signal's fluctuations over the submultiple periods of the data stream can be acquired at each wavelength (or frequency). From the autocorrelations of submultiple sets, we find only some fraction of these fluctuations consist of stochastic noise. Part of the fluctuations are what we call "fast drift", which is defined as drift over a time shorter than the complete measurement period of the average spectrum. In effect, what is usually assumed to be stochastic noise has a significant component of fast drift due to changes of conditions in the spectroscopic system. In addition, we show that the extreme values of the fluctuation of the signals are usually not balanced (equal magnitudes, equal probabilities) on either side of the mean or median without an inconveniently long measurement time; the data is almost inevitably biased. In other words, the unbalanced data is collected in an unbalanced manner around the mean, and so the median provides a better measure of the true spectrum. As is shown here, by using the medians of these distributions, the signal-to-noise of the spectrum can be increased and sampling bias reduced. The effect of this submultiple median data treatment is demonstrated for infrared, circular dichroism, and Raman spectrometry.

Duration ratio discrimination in pigeons: a criterion-setting analysis.

PubMed

Fetterman, J Gregor

2006-02-28

Pigeons received trials beginning with a sequence of two colors (blue-->yellow) on the center key of a three-key array. The colors lasted different lengths of time. At the end of the sequence pigeons chose between two keys based on a criterial ratio of the temporal sequence. One choice was reinforced if the time ratio was less than the criterion and the alternate choice was reinforced if the time ratio was greater than the criterion. The criterial ratios (first to second duration) were 1:1, 1.5:1, and 3:1. The same set of intervals was used for the different criterion ratios, producing a balanced distribution of time ratios for the 1.5:1 condition, and unbalanced distributions for the 1:1 and 3:1 conditions. That is, for the 1.5:1 condition half of the duration pairs were less than the criterion and half were greater. However, for the 1:1 and 3:1 conditions, more duration pairs were less than (3:1) or greater than (1:1) the criterion. Accuracy was similar across criterion ratios, but response bias was influenced by the asymmetries of time ratios in the 1:1 and 3:1 conditions. When these asymmetries were controlled, the response biases were reduced or eliminated. These results indicate that pigeons are flexible in establishing a criterion for discriminating duration ratios, unlike humans, who are less flexible and are bound to categorical distinctions in the discrimination of duration ratios.

Gender and Number Agreement in the Oral Production of Arabic Heritage Speakers

ERIC Educational Resources Information Center

Albirini, Abdulkafi; Benmamoun, Elabbas; Chakrani, Brahim

2013-01-01

Heritage language acquisition has been characterized by various asymmetries, including the differential acquisition rates of various linguistic areas and the unbalanced acquisition of different categories within a single area. This paper examines Arabic heritage speakers' knowledge of subject-verb agreement versus noun-adjective agreement with the…

Fad reducing diets: separating fads from facts.

PubMed

Blackburn, G L; Pavlou, K

1984-01-01

Generally, it is wise to stay away from any crash diet. All tend to be nutritionally unbalanced. Although all may cause great temporary weight losses in short periods of time, over the long term, the only thing they accomplish is the addition of another cycle of frustration and disappointment for the dieter.

Multilevel Analysis of Structural Equation Models via the EM Algorithm.

ERIC Educational Resources Information Center

Jo, See-Heyon

The question of how to analyze unbalanced hierarchical data generated from structural equation models has been a common problem for researchers and analysts. Among difficulties plaguing statistical modeling are estimation bias due to measurement error and the estimation of the effects of the individual's hierarchical social milieu. This paper…

Unbalancing Acts: Plagiarism as Catalyst for Instructor Emotion in the Composition Classroom

ERIC Educational Resources Information Center

Biswas, Ann E.

2016-01-01

In this essay, the author reflects on her experiences while researching composition instructors' emotional responses to plagiarism. The research found that instructors faced a variety of complex and competing feelings when students plagiarized, and those responses threatened to upset relationships, power structures, and professional identities in…

Verbal and Nonverbal Cognitive Control in Bilinguals and Interpreters

ERIC Educational Resources Information Center

Woumans, Evy; Ceuleers, Evy; Van der Linden, Lize; Szmalec, Arnaud; Duyck, Wouter

2015-01-01

The present study explored the relation between language control and nonverbal cognitive control in different bilingual populations. We compared monolinguals, Dutch-French unbalanced bilinguals, balanced bilinguals, and interpreters on the Simon task (Simon & Rudell, 1967) and the Attention Network Test (ANT; Fan, McCandliss, Sommer, Raz,…

Bidding strategy for microgrid in day-ahead market based on hybrid stochastic/robust optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Guodong; Xu, Yan; Tomsovic, Kevin

In this paper, we propose an optimal bidding strategy in the day-ahead market of a microgrid consisting of intermittent distributed generation (DG), storage, dispatchable DG and price responsive loads. The microgrid coordinates the energy consumption or production of its components and trades electricity in both the day-ahead and real-time markets to minimize its operating cost as a single entity. The bidding problem is challenging due to a variety of uncertainties, including power output of intermittent DG, load variation, day-ahead and real-time market prices. A hybrid stochastic/robust optimization model is proposed to minimize the expected net cost, i.e., expected total costmore » of operation minus total benefit of demand. This formulation can be solved by mixed integer linear programming. The uncertain output of intermittent DG and day-ahead market price are modeled via scenarios based on forecast results, while a robust optimization is proposed to limit the unbalanced power in real-time market taking account of the uncertainty of real-time market price. Numerical simulations on a microgrid consisting of a wind turbine, a PV panel, a fuel cell, a micro-turbine, a diesel generator, a battery and a responsive load show the advantage of stochastic optimization in addition to robust optimization.« less

Bidding strategy for microgrid in day-ahead market based on hybrid stochastic/robust optimization

DOE PAGES

Liu, Guodong; Xu, Yan; Tomsovic, Kevin

2016-01-01

In this paper, we propose an optimal bidding strategy in the day-ahead market of a microgrid consisting of intermittent distributed generation (DG), storage, dispatchable DG and price responsive loads. The microgrid coordinates the energy consumption or production of its components and trades electricity in both the day-ahead and real-time markets to minimize its operating cost as a single entity. The bidding problem is challenging due to a variety of uncertainties, including power output of intermittent DG, load variation, day-ahead and real-time market prices. A hybrid stochastic/robust optimization model is proposed to minimize the expected net cost, i.e., expected total costmore » of operation minus total benefit of demand. This formulation can be solved by mixed integer linear programming. The uncertain output of intermittent DG and day-ahead market price are modeled via scenarios based on forecast results, while a robust optimization is proposed to limit the unbalanced power in real-time market taking account of the uncertainty of real-time market price. Numerical simulations on a microgrid consisting of a wind turbine, a PV panel, a fuel cell, a micro-turbine, a diesel generator, a battery and a responsive load show the advantage of stochastic optimization in addition to robust optimization.« less

Monitoring techniques for the X-29A aircraft's high-speed rotating power takeoff shaft

NASA Technical Reports Server (NTRS)

Voracek, David F.

1990-01-01

The experimental X-29A forward swept-wing aircraft has many unique and critical systems that require constant monitoring during ground or flight operation. One such system is the power takeoff shaft, which is the mechanical link between the engine and the aircraft-mounted accessory drive. The X-29A power takeoff shaft opertes in a range between 0 and 16,810 rpm, is longer than most jet engine power takeoff shafts, and is made of graphite epoxy material. Since the X-29A aircraft operates on a single engine, failure of the shaft during flight could lead to loss of the aircraft. The monitoring techniques and test methods used during power takeoff shaft ground and flight operations are discussed. Test data are presented in two case studies where monitoring and testing of the shaft dynamics proved instrumental in discovering and isolating X-29A power takeoff shaft problems. The first study concerns the installation of an unbalanced shaft. The effect of the unbalance on the shaft vibration data and the procedure used to correct the problem are discussed. The second study deals with the shaft exceeding the established vibration limits during flight. This case study found that the vibration of connected rotating machinery unbalances contributed to the excessive vibration level of the shaft. The procedures used to identify the contributions of other rotating machinery unbalances to the power takeoff shaft unbalance are discussed.

Rectangular QPSK for generation of optical eight-ary phase-shift keying.

PubMed

Lu, Guo-Wei; Sakamoto, Takahide; Kawanishi, Tetsuya

2011-09-12

Quadrature phase-shift keying (QPSK) is usually generated using an in-phase/quadrature (IQ) modulator in a balanced driving-condition, showing a square-shape constellation in complex plane. This conventional QPSK is referred to as square QPSK (S-QPSK) in this paper. On the other hand, when an IQ modulator is driven in an un-balanced manner with different amplitudes in in-phase (I) and quadrature (Q) branches, a rectangular QPSK (R-QPSK) could be synthesized. The concept of R-QPSK is proposed for the first time and applied to optical eight-ary phase-shift keying (8PSK) transmitter. By cascading an S-QPSK and an R-QPSK, an optical 8PSK could be synthesized. The transmitter configuration is based on two cascaded IQ modulators, which also could be used to generate other advanced multi-level formats like quadrature amplitude modulation (QAM) when different driving and bias conditions are applied. Therefore, the proposed transmitter structure has potential to be deployed as a versatile transmitter for synthesis of several different multi-level modulation formats for the future dynamic optical networks. A 30-Gb/s optical 8PSK is experimentally demonstrated using the proposed solution.

Drug-disease interactions: narrative review of aspirin in gastric ulcer.

PubMed

Nwose, Ezekiel Uba; Yee, Kwang Choon

2016-09-01

Drug-disease interactions include the impact of a drug and a particular disease condition on each other. However, the current practice in addressing drug-disease interaction is unbalanced and mostly limited to how the drug worsens the disease or health condition. Aspirin and gastric ulcer interaction are used as an example to illustrate this concept, especially the narration of how disease affects drug efficacy. The number of molecules that make up 100 mg of aspirin is identified with a view to discuss the pharmacokinetics, especially in terms of absorption and distribution. Using hypothetical scenarios, the pharmacodynamics in co-morbidities that could involve gastric ulcer and aspirin are also discussed. There seems to be oversight in definition and description of drug-disease interaction, which is often limited to 'how drug exacerbates disease'. The implication of this limited definition is that the discussions, research and teaching of the topic either lacks information, or are not clear on 'how disease affects drug efficacy'. For example, gastric ulcer has the potential to enhance absorption, bioavailability and therapeutic effects of aspirin, but this is rarely discussed in preference to the probability of gastro-intestinal bleeding side-effect.

Unbalanced Bilingual Acquisition as a Mechanism of Grammatical Change

ERIC Educational Resources Information Center

Matthews, Stephen; Yip, Virginia

2011-01-01

Bilingual first language acquisition (BFLA) has been considered a possible mechanism of contact-induced change in several recent studies (Siegel, 2008, p. 117; Satterfield, 2005, p. 2075; Thomason, 2001, p. 148; Yip & Matthews, 2007, p.15). There is as yet little consensus on the question, with divergent views regarding both BFLA at the individual…

Associated Factors for Self-Reported Binge Eating among Male and Female Adolescents.

ERIC Educational Resources Information Center

Ledoux, Sylvie; And Others

1993-01-01

Adolescents (n=3,287) completed questionnaire concerning eating behaviors. Found that binge eaters had disorderly eating habits (skipping meals, snacking, eating sweets, unbalanced diets), concern with body shape (feeling too fat), and depressive symptoms more often than nonbinge eaters did. Relationship between binging episodes and eating habits,…

Modulation of Language Switching by Cue Timing: Implications for Models of Bilingual Language Control

ERIC Educational Resources Information Center

Khateb, Asaid; Shamshoum, Rana; Prior, Anat

2017-01-01

The current study examines the interplay between global and local processes in bilingual language control. We investigated language-switching performance of unbalanced Arabic-Hebrew bilinguals in cued picture naming, using 5 different cuing parameters. The language cue could precede the picture, follow it, or appear simultaneously with it. Naming…

Unbalanced activation of glutathione metabolic pathways suggests potential involvement in plant defense against the gall midge mayetiola destructor in wheat

USDA-ARS?s Scientific Manuscript database

Glutathione, a thiol tripeptide of '-glutamylcysteinylglycine, exists abundantly in nearly all organisms. Glutathione participates in various physiological processes involved in redox reactions by serving as an electron donor/acceptor. In this study, we found that the abundance of total glutathion...

Teacher Allocation Policies and the Unbalanced Distribution of Novice and Senior Teachers across Regions in Turkey

ERIC Educational Resources Information Center

Özoglu, Murat; Beyazit, Yildirim

2015-01-01

Policies toward fostering a more balanced distribution of teacher quality have garnered considerable attention from researchers and policymakers around the world. This attention has been motivated largely by the widely acknowledged educational goal of providing quality education for all children. Equipped with similar policy concerns, this study…

Fan blade protection system

NASA Technical Reports Server (NTRS)

Hermans, Thomas C. (Inventor); Wakeman, Thomas G. (Inventor); Hauser, Ambrose A. (Inventor)

1993-01-01

In one type of aircraft propulsion system, propeller blades are mounted on a ring which surrounds a turbine. An annular space exists between the turbine and the ring. If a propeller blade should break free, the unbalanced centrifugal load tends to deform the ring. The invention reduces the deformation, as by locating spacers between the turbine and the ring.

Taking a Hard Look at Formal Mentoring Programs: A Consideration of the Potential Challenges Facing Women.

ERIC Educational Resources Information Center

Blake-Beard, Stacy D.

2001-01-01

Comparison of women in formal and informal mentoring relationships showed that formal mentoring often led to unrealistic expectations; unbalanced focus on proteges; difficulty managing relationships among supervisors, proteges, and mentors; and damage from gossip. Informal mentoring may provide psychosocial and career support without these…

Intensity-based fibre-optic sensing system using contrast modulation of subcarrier interference pattern

NASA Technical Reports Server (NTRS)

Adamovsky, G.; Sherer, T. N.; Maitland, D. J.

1989-01-01

A novel technique to compensate for unwanted intensity losses in a fiber-optic sensing system is described. The technique involves a continuous sinusoidal modulation of the light source intensity at radio frequencies and an intensity sensor placed in an unbalanced interferometer. The system shows high sensitivity and stability.

Preserving Social Studies as Core Curricula in an Era of Common Core Reform

ERIC Educational Resources Information Center

Denton, David W.; Sink, Cindy

2015-01-01

Education reform over the last two decades has changed perceptions of core curricula. Although social studies has traditionally been part of the core, emphasis on standards-based teaching and learning, along with elaborate accountability schemes, is causing unbalanced treatment of subjects. While the research literature indicates teachers are…

Changes in Thought on Higher Education for the Twenty-First Century

ERIC Educational Resources Information Center

Maoyuan, Pan

2007-01-01

The reforms and developments of China's higher education at a time when it faces two great challenges--the world's science/technology revolution and China's social market economy--are, on the whole, replete with achievements and fraught with difficulties and show great changes, but they are unbalanced. Everyone feels that these reforms and…

Income Inequality, Global Economy and the State

ERIC Educational Resources Information Center

Lee, Cheol-Sung; Nielsen, Francois; Alderson, Arthur S.

2007-01-01

We investigate interrelationship among income inequality, global economy and the role of the state using an unbalanced panel data set with 311 observations on 60 countries, dated from 1970 to 1994. The analysis proceeds in two stages. First, we test for effects on income inequality of variables characterizing the situation of a society in the…

Sex-Biased Ratio of Avoidant/Ambivalent Attachment in Middle Childhood

ERIC Educational Resources Information Center

Del Giudice, Marco

2008-01-01

In this study, new evidence is presented of marked sex differences in the distribution of insecure attachment patterns in middle childhood. Attachment was assessed with the Manchester Child Attachment Story Task (MCAST) in a sample of 122 Italian 7-year-olds. The four-way distribution of attachment patterns was significantly unbalanced, with…

AST/R–BASED WATER REUSE AS A PART OF THE TOTAL WATER SOLUTION FOR WATER-STRESSED REGIONS: AN OVERVIEW OF ENGINEERING PRACTICE AND REGULATORY PROSPECTIVE

EPA Science Inventory

Water supply and demand are increasingly unbalanced in many parts of the world. To address the imbalance, the total water solution methodology simultaneously considers regulatory, engineering, environmental and economic factors to optimize risk management solutions for an entire...

AST/R BASED WATER REUSE AS A PART OF THE TOTAL WATER SOLUTION FOR WATER-STRESSED REGIONS: AN OVERVIEW OF ENGINEERING PRACTICE AND REGULATORY PROSPECTIVE

EPA Science Inventory

Water supply and demand are increasingly unbalanced in many parts of the world. To address the imbalance, the total water solution methodology simultaneously considers regulatory, engineering, environmental and economic factors to optimize risk management solutions for an entire ...

Not All Ambiguous Words Are Created Equal: An EEG Investigation of Homonymy and Polysemy

ERIC Educational Resources Information Center

Klepousniotou, Ekaterini; Pike, G. Bruce; Steinhauer, Karsten; Gracco, Vincent

2012-01-01

Event-related potentials (ERPs) were used to investigate the time-course of meaning activation of different types of ambiguous words. Unbalanced homonymous ("pen"), balanced homonymous ("panel"), metaphorically polysemous ("lip"), and metonymically polysemous words ("rabbit") were used in a visual single-word priming delayed lexical decision task.…

Lessons in Learning: Understanding the Academic Trajectories of ESL Students

ERIC Educational Resources Information Center

Canadian Council on Learning, 2008

2008-01-01

Canada depends on a steady flow of immigrants to maintain a viable workforce within an aging population. Without immigration, Canada's dependency ratio--the number of employed versus non-employed individuals--would grow dangerously unbalanced. In recent years, most immigrants have come from countries where the spoken language is not English or…

International Sexual Partnerships May Be Shaped by Sexual Histories and Socioeconomic Status.

PubMed

Truong, Hong-Ha M; Mehrotra, Megha; Montoya, Orlando; Lama, Javier R; Guanira, Juan V; Casapía, Martín; Veloso, Valdiléa G; Buchbinder, Susan P; Mayer, Kenneth H; Chariyalertsak, Suwat; Schechter, Mauro; Bekker, Linda-Gail; Kallás, Esper G; Grant, Robert M

2017-05-01

Exchange sex and higher education were associated with an increased likelihood of international sexual partnerships (ISPs). Exchange sex and older age were associated with an increased likelihood of condomless sex in ISPs. Educational and socioeconomic factors may create unbalanced power dynamics that influence exchange sex and condomless sex in ISPs.

Antecedents for Interrole Conflict in the High School Teacher/Coach

ERIC Educational Resources Information Center

Ryan, Timothy D.

2008-01-01

Antecedents for interrole conflict between the teaching role and coaching role for the high school teacher coach (TC) were examined. It was expected that younger TCs, those in smaller schools, TCs with more coaching jobs, or TCs with an unbalanced role preference will experience more conflict between the teaching and coaching role. Using…

The Body Politic: Childhood Obesity as a Symbol of an Unbalanced Economy

ERIC Educational Resources Information Center

Kroner, Crystal

2011-01-01

As society's novices, children are becoming more susceptible to advertisers who target them as a profitable demographic. This creates an alarming trend of obesity and exacts a considerable financial, physical and ethical toll on the community. To view obesity as concurrent with malnourishment seems counter-intuitive, this study uses Butler's…

Hysteresis Control of Parallel-Connected Hybrid Inverters

DTIC Science & Technology

2005-09-01

92 C. MILITARY APPLICATIONS .....................................................................92 D...unbalanced to replicate the “real-world” application of the controller. Other areas of the controller could be changed to improve the fidelity of the load...a chip to perform the complex mathematics to transform from one reference frame to another while automatically adjusting the filter parameters. The

Bilingualism and Processing of Elementary Cognitive Tasks by Chicano Adolescents.

ERIC Educational Resources Information Center

Nanez, Jose E., Sr.; Padilla, Raymond V.

1995-01-01

Two experiments conducted with 49 Chicano high school students, aged 15-17, found that balanced-proficient bilingual speakers had slower rates of cognitive information processing at the level of short-term memory than did unbalanced bilingual speakers. The groups did not differ in rates of cognitive information processing at the simpler level of…

Carbon Nanotube Thin-Film Antennas.

PubMed

Puchades, Ivan; Rossi, Jamie E; Cress, Cory D; Naglich, Eric; Landi, Brian J

2016-08-17

Multiwalled carbon nanotube (MWCNT) and single-walled carbon nanotube (SWCNT) dipole antennas have been successfully designed, fabricated, and tested. Antennas of varying lengths were fabricated using flexible bulk MWCNT sheet material and evaluated to confirm the validity of a full-wave antenna design equation. The ∼20× improvement in electrical conductivity provided by chemically doped SWCNT thin films over MWCNT sheets presents an opportunity for the fabrication of thin-film antennas, leading to potentially simplified system integration and optical transparency. The resonance characteristics of a fabricated chlorosulfonic acid-doped SWCNT thin-film antenna demonstrate the feasibility of the technology and indicate that when the sheet resistance of the thin film is >40 ohm/sq no power is absorbed by the antenna and that a sheet resistance of <10 ohm/sq is needed to achieve a 10 dB return loss in the unbalanced antenna. The dependence of the return loss performance on the SWCNT sheet resistance is consistent with unbalanced metal, metal oxide, and other CNT-based thin-film antennas, and it provides a framework for which other thin-film antennas can be designed.

Control method of Three-phase Four-leg converter based on repetitive control

NASA Astrophysics Data System (ADS)

Hui, Wang

2018-03-01

The research chose the magnetic levitation force of wind power generation system as the object. In order to improve the power quality problem caused by unbalanced load in power supply system, we combined the characteristics and repetitive control principle of magnetic levitation wind power generation system, and then an independent control strategy for three-phase four-leg converter was proposed. In this paper, based on the symmetric component method, the second order generalized integrator was used to generate the positive and negative sequence of signals, and the decoupling control was carried out under the synchronous rotating reference frame, in which the positive and negative sequence voltage is PI double closed loop, and a PI regulator with repetitive control was introduced to eliminate the static error regarding the fundamental frequency fluctuation characteristic of zero sequence component. The simulation results based on Matlab/Simulink show that the proposed control project can effectively suppress the disturbance caused by unbalanced loads and maintain the load voltage balance. The project is easy to be achieved and remarkably improves the quality of the independent power supply system.

Research concerning the balancing of a plane mechanism

NASA Astrophysics Data System (ADS)

Bădoiu, D.; Petrescu, M. G.; Antonescu, N. N.; Toma, G.

2018-01-01

By statically balancing of the plane mechanisms and especially those functioning at high speeds is being pursued the decrease of the value of the resultant force of all inertia forces that work on the component elements, thus obtaining a significant decrease in vibrations and shocks during the functioning. On the other hand, the existence of balancing masses which ensure the balancing of the mechanism leads to increased gauge and its mass. In this paper are presented some possibilities of statically balancing a plane mechanism which is composed of three independent contours. First is analyzed the case when the mechanism is totally balanced. Then a solution is proposed for a partial balancing of the mechanism based on the balancing of the first harmonic of the inertia force developed in a piston of the mechanism. Finally, are presented some simulation results concerning the variation of the value of the resultant inertia force during a cinematic cycle when the mechanism is unbalanced and when it is partially balanced. Also, it is analyzed the variation of the motor moment when the mechanism is unbalanced and when is totally and partially balanced.

Optimal SVM parameter selection for non-separable and unbalanced datasets.

PubMed

Jiang, Peng; Missoum, Samy; Chen, Zhao

2014-10-01

This article presents a study of three validation metrics used for the selection of optimal parameters of a support vector machine (SVM) classifier in the case of non-separable and unbalanced datasets. This situation is often encountered when the data is obtained experimentally or clinically. The three metrics selected in this work are the area under the ROC curve (AUC), accuracy, and balanced accuracy. These validation metrics are tested using computational data only, which enables the creation of fully separable sets of data. This way, non-separable datasets, representative of a real-world problem, can be created by projection onto a lower dimensional sub-space. The knowledge of the separable dataset, unknown in real-world problems, provides a reference to compare the three validation metrics using a quantity referred to as the "weighted likelihood". As an application example, the study investigates a classification model for hip fracture prediction. The data is obtained from a parameterized finite element model of a femur. The performance of the various validation metrics is studied for several levels of separability, ratios of unbalance, and training set sizes.

Comparison of Deterministic and Probabilistic Radial Distribution Systems Load Flow

NASA Astrophysics Data System (ADS)

Gupta, Atma Ram; Kumar, Ashwani

2017-12-01

Distribution system network today is facing the challenge of meeting increased load demands from the industrial, commercial and residential sectors. The pattern of load is highly dependent on consumer behavior and temporal factors such as season of the year, day of the week or time of the day. For deterministic radial distribution load flow studies load is taken as constant. But, load varies continually with a high degree of uncertainty. So, there is a need to model probable realistic load. Monte-Carlo Simulation is used to model the probable realistic load by generating random values of active and reactive power load from the mean and standard deviation of the load and for solving a Deterministic Radial Load Flow with these values. The probabilistic solution is reconstructed from deterministic data obtained for each simulation. The main contribution of the work is: Finding impact of probable realistic ZIP load modeling on balanced radial distribution load flow. Finding impact of probable realistic ZIP load modeling on unbalanced radial distribution load flow. Compare the voltage profile and losses with probable realistic ZIP load modeling for balanced and unbalanced radial distribution load flow.

Ploidy dimorphism and reproductive biology in Stenodrepanum bergii (Leguminosae), a rare South American endemism.

PubMed

Caponio, Irene; Anton, Ana M; Fortunato, Renée H; Norrmann, G A

2012-01-01

This is the first report on chromosome numbers and the reproductive behaviour in Stenodrepanum Harms, a rare endemic and monotypic legume genus from the arid and salty areas of central-western Argentina. Sixty individuals belonging to two populations from two salty areas ("salinas") were surveyed and included mostly triploid (2n = 3x = 36) and only two diploid (2n = 2x = 24) plants. Meiosis in diploids is regular, with bivalent pairing and uniform and viable pollen. In contrast, meiosis in triploids is characterized by high trivalent pairing, with irregularly shaped pollen and variation in cytoplasm content and stainability, which is in agreement with an unbalanced segregation occurring in anaphases I and II. However, different triploid plants/individuals showed various degrees of pollen fertility, which may be attributed to particular genotypes. Research on reproductive biology events indicates sexual cross-pollinated reproduction enhanced by protogyny in both cytotypes. All plants produced seeds, but seedlings were only recovered from diploid plants pollinated with triploids, and even those eventually perished. Chromosome counts in these seedlings revealed aneuploid chromosome numbers owing to the combination of unbalanced gametes.

Results of a laboratory experiment that tests rotating unbalanced-mass devices for scanning gimbaled payloads and free-flying spacecraft

NASA Technical Reports Server (NTRS)

Alhorn, D. C.; Polites, M. E.

1994-01-01

Rotating unbalanced-mass (RUM) devices are a new way to scan space-based, balloon-borne, and ground-based gimbaled payloads, like x-ray and gamma-ray telescopes. They can also be used to scan free-flying spacecraft. Circular scans, linear scans, and raster scans can be generated. A pair of RUM devices generates the basic scan motion and an auxiliary control system using torque motors, control moment gyros, or reaction wheels keeps the scan centered on the target and produces some complementary motion for raster scanning. Previous analyses and simulation results show that this approach offers significant power savings compared to scanning only with the auxiliary control system, especially with large payloads and high scan frequencies. However, these claims have never been proven until now. This paper describes a laboratory experiment which tests the concept of scanning a gimbaled payload with RUM devices. A description of the experiment is given and test results that prove the concept are presented. The test results are compared with those from a computer simulation model of the experiment and the differences are discussed.

A comparative study of stabilizing control of a planer electromagnetic levitation using PID and LQR controllers

NASA Astrophysics Data System (ADS)

Yaseen, Mundher H. A.

Magnetic levitation is a technique to suspend an object without any mechanical support. The main objective of this study is to demonstrate stabilized closed loop control of 1-DOF Maglev experimentally using real-time control simulink feature of (SIMLAB) microcontroller. Proportional Integral Derivative (PID) and Linear Quadratic Regulator (LQR) controllers are employed to examine the stability performance of the Maglev control system under effect of unbalanced change of load and wave signal on Maglev plane. The effect of unbalanced change of applied load on single point, line and plane are presented. Furthermore, in order to study the effect of sudden change in input signal, the input of wave signal has been applied on all points of the prototype maglev plate simultaneously. The results of pulse width modulation (PWM) reveal that the control system using LQR controller provides faster response to adjust the levitated plane comparing to PID controller. Moreover, the air gap distance that controlled using PID controller is rather stable with little oscillation. Meanwhile, LQR controller provided more stability and homogeneous response.

Sucrose Sensitivity of Honey Bees Is Differently Affected by Dietary Protein and a Neonicotinoid Pesticide

PubMed Central

Démares, Fabien J.; Crous, Kendall L.; Pirk, Christian W. W.; Nicolson, Susan W.; Human, Hannelie

2016-01-01

Over a decade, declines in honey bee colonies have raised worldwide concerns. Several potentially contributing factors have been investigated, e.g. parasites, diseases, and pesticides. Neonicotinoid pesticides have received much attention due to their intensive use in crop protection, and their adverse effects on many levels of honey bee physiology led the European Union to ban these compounds. Due to their neuronal target, a receptor expressed throughout the insect nervous system, studies have focused mainly on neuroscience and behaviour. Through the Geometric Framework of nutrition, we investigated effects of the neonicotinoid thiamethoxam on survival, food consumption and sucrose sensitivity of honey bees (Apis mellifera). Thiamethoxam did not affect protein and carbohydrate intake, but decreased responses to high concentrations of sucrose. Interestingly, when bees ate fixed unbalanced diets, dietary protein facilitated better sucrose detection. Both thiamethoxam and dietary protein influenced survival. These findings suggest that, in the presence of a pesticide and unbalanced food, honey bee health may be severely challenged. Consequences for foraging efficiency and colony activity, cornerstones of honey bee health, are also discussed. PMID:27272274

Surface treatment effect on Si (111) substrate for carbon deposition using DC unbalanced magnetron sputtering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aji, A. S., E-mail: aji.ravazes70@gmail.com; Sahdan, M. F.; Hendra, I. B.

In this work, we studied the effect of HF treatment in silicon (111) substrate surface for depositing thin layer carbon. We performed the deposition of carbon by using DC Unbalanced Magnetron Sputtering with carbon pallet (5% Fe) as target. From SEM characterization results it can be concluded that the carbon layer on HF treated substrate is more uniform than on substrate without treated. Carbon deposition rate is higher as confirmed by AFM results if the silicon substrate is treated by HF solution. EDAX characterization results tell that silicon (111) substrate with HF treatment have more carbon fraction than substrate withoutmore » treatment. These results confirmed that HF treatment on silicon Si (111) substrates could enhance the carbon deposition by using DC sputtering. Afterward, the carbon atomic arrangement on silicon (111) surface is studied by performing thermal annealing process to 900 °C. From Raman spectroscopy results, thin film carbon is not changing until 600 °C thermal budged. But, when temperature increase to 900 °C, thin film carbon is starting to diffuse to silicon (111) substrates.« less

Propensity score to detect baseline imbalance in cluster randomized trials: the role of the c-statistic.

PubMed

Leyrat, Clémence; Caille, Agnès; Foucher, Yohann; Giraudeau, Bruno

2016-01-22

Despite randomization, baseline imbalance and confounding bias may occur in cluster randomized trials (CRTs). Covariate imbalance may jeopardize the validity of statistical inferences if they occur on prognostic factors. Thus, the diagnosis of a such imbalance is essential to adjust statistical analysis if required. We developed a tool based on the c-statistic of the propensity score (PS) model to detect global baseline covariate imbalance in CRTs and assess the risk of confounding bias. We performed a simulation study to assess the performance of the proposed tool and applied this method to analyze the data from 2 published CRTs. The proposed method had good performance for large sample sizes (n =500 per arm) and when the number of unbalanced covariates was not too small as compared with the total number of baseline covariates (≥40% of unbalanced covariates). We also provide a strategy for pre selection of the covariates needed to be included in the PS model to enhance imbalance detection. The proposed tool could be useful in deciding whether covariate adjustment is required before performing statistical analyses of CRTs.

Influence of substrate bias voltage on structure and properties of the CrAlN films deposited by unbalanced magnetron sputtering

NASA Astrophysics Data System (ADS)

Lv, Yanhong; Ji, Li; Liu, Xiaohong; Li, Hongxuan; Zhou, Huidi; Chen, Jianmin

2012-02-01

The CrAlN films were deposited on silicon and stainless steel substrates by unbalanced magnetron sputtering system. The influence of substrate bias on deposition rate, composition, structure, morphology and properties of the CrAlN films was investigated. The results showed that, with the increase of the substrate bias voltage, the deposition rate decreased accompanied by a change of the preferred orientation of the CrAlN film from (2 2 0) to (2 0 0). The grain size and the average surface roughness of the CrAlN films declined as the bias voltage increases above -100 V. The morphology of the films changed from obviously columnar to dense glass-like structure with the increase of the bias voltage from -50 to -250 V. Meanwhile, the films deposited at moderate bias voltage had better mechanical and tribological properties, while the films deposited at higher bias voltage showed better corrosion resistance. It was found that the corrosion resistance improvement was not only attributed to the low pinhole density of the film, but also to chemical composition of films.

SPEEDY babies: A putative new behavioral syndrome of unbalanced motor-speech development

PubMed Central

Haapanen, Marja-Leena; Aro, Tuomo; Isotalo, Elina

2008-01-01

Even though difficulties in motor development in children with speech and language disorders are widely known, hardly any attention is paid to the association between atypically rapidly occurring unassisted walking and delayed speech development. The four children described here presented with a developmental behavioral triad: 1) atypically speedy motor development, 2) impaired expressive speech, and 3) tongue carriage dysfunction resulting in related misarticulations. Those characteristics might be phenotypically or genetically clustered. These children didn’t have impaired cognition, neurological or mental disease, defective sense organs, craniofacial dysmorphology or susceptibility to upper respiratory infections, particularly recurrent otitis media. Attention should be paid on discordant and unbalanced achievement of developmental milestones. Present children are termed SPEEDY babies, where SPEEDY refers to rapid independent walking, SPEE and DY to dyspractic or dysfunctional speech development and lingual dysfunction resulting in linguoalveolar misarticulations. SPEEDY babies require health care that recognizes and respects their motor skills and supports their needs for motor activities and on the other hand include treatment for impaired speech. The parents may need advice and support with these children. PMID:19337462

Sucrose Sensitivity of Honey Bees Is Differently Affected by Dietary Protein and a Neonicotinoid Pesticide.

PubMed

Démares, Fabien J; Crous, Kendall L; Pirk, Christian W W; Nicolson, Susan W; Human, Hannelie

2016-01-01

Over a decade, declines in honey bee colonies have raised worldwide concerns. Several potentially contributing factors have been investigated, e.g. parasites, diseases, and pesticides. Neonicotinoid pesticides have received much attention due to their intensive use in crop protection, and their adverse effects on many levels of honey bee physiology led the European Union to ban these compounds. Due to their neuronal target, a receptor expressed throughout the insect nervous system, studies have focused mainly on neuroscience and behaviour. Through the Geometric Framework of nutrition, we investigated effects of the neonicotinoid thiamethoxam on survival, food consumption and sucrose sensitivity of honey bees (Apis mellifera). Thiamethoxam did not affect protein and carbohydrate intake, but decreased responses to high concentrations of sucrose. Interestingly, when bees ate fixed unbalanced diets, dietary protein facilitated better sucrose detection. Both thiamethoxam and dietary protein influenced survival. These findings suggest that, in the presence of a pesticide and unbalanced food, honey bee health may be severely challenged. Consequences for foraging efficiency and colony activity, cornerstones of honey bee health, are also discussed.

Understanding the Inflammatory Cytokine Response in Pneumonia and Sepsis

PubMed Central

Kellum, John A.; Kong, Lan; Fink, Mitchell P.; Weissfeld, Lisa A.; Yealy, Donald M.; Pinsky, Michael R.; Fine, Jonathan; Krichevsky, Alexander; Delude, Russell L.; Angus, Derek C.

2015-01-01

Background Severe sepsis is common and frequently fatal, and community-acquired pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to uncontrolled and unbalanced inflammation, evidence from humans with infection syndromes across the breadth of disease is lacking. In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of pro-inflammatory and anti-inflammatory markers, are associated with severe sepsis and death. Methods This is a cohort study of 1886 subjects hospitalized with CAP through the emergency departments in 28 US academic and community hospitals. We defined severe sepsis as CAP complicated by new-onset organ dysfunction, following international consensus conference criteria. We measured plasma tumor necrosis factor, IL-6 (interleukin 6), and IL-10 levels daily for the first week and weekly thereafter. Our main outcome measures were severe sepsis and 90-day mortality. Results A total of 583 patients developed severe sepsis (31%), of whom 149 died (26%). Systemic cytokine level elevation occurred in 82% of all subjects with CAP. Mean cytokine concentrations were highest at presentation, declined rapidly over the first few days, but remained elevated throughout the first week, beyond resolution of clinical signs of infection. Cytokine levels were highest in fatal severe sepsis and lowest in CAP with no severe sepsis. Unbalanced (high/low) cytokine patterns were unusual (4.6%) and not associated with decreased survival. Highest risk of death was with combined high levels of the proinflammatory IL-6 and anti-inflammatory IL-10 cytokine activity (hazard ratio, 20.5; 95% confidence interval, 10.8–39.0) (P<.001). Conclusions The circulating cytokine response to pneumonia is heterogeneous and continues for more than a week after presentation, with considerable overlap between those who do and do not develop severe sepsis. Unbalanced activation is uncommon, and mortality is highest when both proinflammatory and anti-inflammatory cytokine levels are high. PMID:17698689

Unbalanced 2 x 2 Factorial Designs and the Interaction Effect: A Troublesome Combination

PubMed Central

2015-01-01

In this power study, ANOVAs of unbalanced and balanced 2 x 2 datasets are compared (N = 120). Datasets are created under the assumption that H1 of the effects is true. The effects are constructed in two ways, assuming: 1. contributions to the effects solely in the treatment groups; 2. contrasting contributions in treatment and control groups. The main question is whether the two ANOVA correction methods for imbalance (applying Sums of Squares Type II or III; SS II or SS III) offer satisfactory power in the presence of an interaction. Overall, SS II showed higher power, but results varied strongly. When compared to a balanced dataset, for some unbalanced datasets the rejection rate of H0 of main effects was undesirably higher. SS III showed consistently somewhat lower power. When the effects were constructed with equal contributions from control and treatment groups, the interaction could be re-estimated satisfactorily. When an interaction was present, SS III led consistently to somewhat lower rejection rates of H0 of main effects, compared to the rejection rates found in equivalent balanced datasets, while SS II produced strongly varying results. In data constructed with only effects in the treatment groups and no effects in the control groups, the H0 of moderate and strong interaction effects was often not rejected and SS II seemed applicable. Even then, SS III provided slightly better results when a true interaction was present. ANOVA allowed not always for a satisfactory re-estimation of the unique interaction effect. Yet, SS II worked better only when an interaction effect could be excluded, whereas SS III results were just marginally worse in that case. Overall, SS III provided consistently 1 to 5% lower rejection rates of H0 in comparison with analyses of balanced datasets, while results of SS II varied too widely for general application. PMID:25807514

Molecular analysis of DiGeorge Syndrome-related translocation breakpoints in 22q11.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chieffo, C.; Barnoski, B.L.; Emanuel, B.S.

1994-09-01

22q11 demonstrates a high frequency of disease-specific rearrangements. Several of the rearrangements are associated with developmental abnormalities such as DiGeorge Syndrome (DGS), Velocardiofacial Syndrome (VCFS), Cat Eye Syndrome (CES) and Supernumerary der(22)t(11;22) Syndrome. DGS and VCFS involve deletions of 22q11.2 resulting from unbalanced translocations or microdeletions. In contrast, CES and Supernumerary der(22)t(11;22) Syndrome result from duplications of this region via inter- or intra- chromosomal exchange. Although the molecular mechanism giving rise to these rearrangements has yet to be elucidated, the presence of known 22q11 repetitive elements are likely to be involved. GM5878 is a 46,XY,t(10;22) cell line from a balancedmore » translocation carrier father of an unbalanced DGS patient. GM0980 is a cell line from a patient with features of DGS/VCFS with an unbalanced karyotype. Using FISH cosmids, we have localized these translocation breakpoints near pH160b (D22S66) which maps to the center of the DiGeorge chromosomal region (DGCR). To further localize the breakpoint of GM5878, overlapping cosmids spanning this region were used as probes for FISH. Use of additional overlapping cosmids allowed the sublocalization of the breakpoint to a 10kb region. A 4.8 kb BglII fragment predicted to cross the breakpoint was isolated. When this fragment was used as a probe to normal and GM5878 DNA, novel bands were detected in GM5878 DNA digested with EcoRI and BglII. Similar analysis of the GM0980 breakpoint is being pursued. Full molecular characterization of these translocations is in progress using inverse PCR to clone the junctional fragments for sequencing. Detailed analysis of the region may reveal molecular features which make this a rearrangement prone area of the genome and help elucidate its relationship to human cytogenetic disease.« less

der(11)t(11;17): a distinct cytogenetic pathway of advanced stage neuroblastoma (NBL) - detected by spectral karyotyping (SKY).

PubMed

Stark, Batia; Jeison, Marta; Glaser-Gabay, Leticia; Bar-Am, Irit; Mardoukh, Jacques; Ash, Shifra; Atias, Dina; Stein, Jerry; Zaizov, Rina; Yaniv, Isaac

2003-07-18

Conventional cytogenetic, molecular cytogenic and genetic methods disclosed a broad spectrum of genetic abnormalities leading to gain and loss of chromosomal segments in advanced stage neuroblastoma (NBL). Specific correlation between the genetic findings could delineate distinct genetic pathways, of which the biology and prognostic significance is as yet undetermined. Using spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) on metaphases from 16 patients with advanced stage NBL, it was possible to explore the whole spectrum of rearrangement within complex karyotypes and to detect hidden recurrent translocations. All translocations were unbalanced. The most prevalent recurrent unbalanced translocations resulted in 17q gain in 12 patients (75%), 11q loss in nine patients (56%), and 1p deletion/imbalance in eight patients (50%). The most frequent recurrent translocation was der(11)t(11;17) in six patients. Three cytogenetic pathways could be delineated. The first, with six patients, was characterized by the unbalanced translocation der(11)t(11;17), detected only by SKY, resulting in the concomitant 17q gain and 11q loss. No MYCN amplification or 1p deletion (except one patient with 1p imbalance) were found, while 3p deletion, and complex karyotypes were common. The second subgroup, with four patients, had 17q gain and 1p deletion, and in two patients 11q loss, that was apparent only by FISH. 1p deletion occurred through der(1)t(1;17) or del(1p). The third subgroup of four patients was characterized by MYCN amplification with 17q gain and 1p deletion, very rarely with 11q loss (one patient) through a translocation with a non-17q partner. The SKY subclassifications were in accordance with the findings reported by molecular genetic techniques, and may indicate that distinct oncogenes and suppressor genes are involved in the der(11)t(11;17) pathway of advanced stage NBL.

African crop yield reductions due to increasingly unbalanced Nitrogen and Phosphorus consumption

NASA Astrophysics Data System (ADS)

van der Velde, Marijn; Folberth, Christian; Balkovič, Juraj; Ciais, Philippe; Fritz, Steffen; Janssens, Ivan A.; Obersteiner, Michael; See, Linda; Skalský, Rastislav; Xiong, Wei; Peñuealas, Josep

2014-05-01

The impact of soil nutrient depletion on crop production has been known for decades, but robust assessments of the impact of increasingly unbalanced nitrogen (N) and phosphorus (P) application rates on crop production are lacking. Here, we use crop response functions based on 741 FAO maize crop trials and EPIC crop modeling across Africa to examine maize yield deficits resulting from unbalanced N:P applications under low, medium, and high input scenarios, for past (1975), current, and future N:P mass ratios of respectively, 1:0.29, 1:0.15, and 1:0.05. At low N inputs (10 kg/ha), current yield deficits amount to 10% but will increase up to 27% under the assumed future N:P ratio, while at medium N inputs (50 kg N/ha), future yield losses could amount to over 40%. The EPIC crop model was then used to simulate maize yields across Africa. The model results showed relative median future yield reductions at low N inputs of 40%, and 50% at medium and high inputs, albeit with large spatial variability. Dominant low-quality soils such as Ferralsols, which are strongly adsorbing P, and Arenosols with a low nutrient retention capacity, are associated with a strong yield decline, although Arenosols show very variable crop yield losses at low inputs. Optimal N:P ratios, i.e. those where the lowest amount of applied P produces the highest yield (given N input) where calculated with EPIC to be as low as 1:0.5. Finally, we estimated the additional P required given current N inputs, and given N inputs that would allow Africa to close yield gaps (ca. 70%). At current N inputs, P consumption would have to increase 2.3-fold to be optimal, and to increase 11.7-fold to close yield gaps. The P demand to overcome these yield deficits would provide a significant additional pressure on current global extraction of P resources.

Bimolecular crystals with an intercalated structure improve poly(p-phenylenevinylene)-based organic photovoltaic cells.

PubMed

Lim, Kyung-Geun; Park, Jun-Mo; Mangold, Hannah; Laquai, Frédéric; Choi, Tae-Lim; Lee, Tae-Woo

2015-01-01

The exciton dissociation, recombination, and charge transport of bulk heterojunction organic photovoltaic cells (OPVs) is influenced strongly by the nanomorphology of the blend, such as the grain size and the molecular packing. Although it is well known that polymers based on amorphous poly(p-phenylenevinylene) (PPV) have a fundamental limit to their efficiency because of low carrier mobility, which leads to increased recombination and unbalanced charge extraction, herein, we demonstrate that the issue can be overcome by forming bimolecular crystals of an amorphous PPV-based polymer:phenyl-C61 -butyric acid methyl ester (PCBM) intercalated structure. We used amorphous poly(2,5-dioctyloxy-p-phenylene vinylene-alt-2',5'-thienylene vinylene) (PPVTV), which has a simple chemical structure. A reasonably high power conversion efficiency (∼3.5 %) was obtained, although the material has an intrinsically amorphous structure and a relatively large band gap (2.0 eV). We demonstrate a correlation between a well-ordered bimolecular crystal of PPVTV:PCBM and an improved hole mobility of a PPVTV:PCBM film compared to a pristine PPVTV film by using 2 D grazing incidence XRD and space-charge-limited current measurements. Furthermore, we show that the bimolecular crystal structure in high-performance OPVs is related to an optimum molecular packing, which is influenced by the PPVTV:PCBM blending ratio, side-chain length, and molecular weight of the PPVTV polymer. Improved charge transport in PPVTV:PCBM bimolecular crystals leads to a fast sweep out of charges and thus suppression of nongeminate recombination under the operating conditions. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Trisections in Three and Four Dimensions

NASA Astrophysics Data System (ADS)

Koenig, Dale R.

Every closed orientable three dimensional manifold has a Heegaard splitting, a decomposition into two handlebodies. Any two Heegaard splittings of the same manifold can be made isotopic after a finite number of stabilization operations. The notion of trisections, developed by Gay and Kirby, provided an analogue in four dimensions. They showed that any closed smooth orientable four dimensional manifold can be broken into three four dimensional handlebodies, with "niceness" conditions on their intersections, and showed that any two trisections are isotopic after stabilizations. In this thesis we investigate the notion of trisections in both three and four dimensions. In dimension three we define trisections of 3-manifolds and stabilization on these trisections. We use this to define the trisection genus of a 3-manifold. We then present several examples, showing among other things that the trisection genus is not additive under connect sum. We prove a stable equivalence theorem for trisections of 3-manifolds, showing that any two trisections of the same three-manifold can be made isotopic after stabilizations. We also show that trisections of S3 can be very complicated, so there is no analogue of Waldhausen's theorem for trisections of three manifolds. We then move on to trisections in four dimensions. We first show that if there exist four manifolds with unbalanced trisection genus lower than their balanced trisection genus, then trisection genus as defined by Gay and Kirby is not additive under connect sum. We produce several new classes of trisections, including several likely such examples. We include a class of examples that are provably minimal genus. We provide trisection diagrams for many of these trisections, and summarize some methods for quickly checking that these diagrams produce valid trisections.

Detailed Microstructural Characterization and Restoration Mechanisms of Duplex and Superduplex Stainless Steel Friction-Stir-Welded Joints

NASA Astrophysics Data System (ADS)

Santos, T. F. A.; Torres, E. A.; Lippold, J. C.; Ramirez, A. J.

2016-12-01

Duplex stainless steels are successfully used in a wide variety of applications in areas such as the food industry, petrochemical installations, and sea water desalination plants, where high corrosion resistance and high mechanical strength are required. However, during fusion welding operations, there can be changes to the favorable microstructure of these materials that compromise their performance. Friction stir welding with a non-consumable pin enables welded joints to be obtained in the solid state, which avoids typical problems associated with solidification of the molten pool, such as segregation of alloying elements and the formation of solidification and liquefaction cracks. In the case of superduplex stainless steels, use of the technique can avoid unbalanced proportions of ferrite and austenite, formation of deleterious second phases, or growth of ferritic grains in the heat-affected zone. Consolidated joints with full penetration were obtained for 6-mm-thick plates of UNS S32101 and S32205 duplex stainless steels, and S32750 and S32760 superduplex steels. The welding heat cycles employed avoided the conditions required for formation of deleterious phases, except in the case of the welded joint of the S32760 steel, where SEM images indicated the formation of secondary phases, as corroborated by decreased mechanical performance. Analysis using EBSD and transmission electron microscopy revealed continuous dynamic recrystallization by the formation of cellular arrays of dislocations in the ferrite and discontinuous dynamic recrystallization in the austenite. Microtexture evaluation indicated the presence of fibers typical of shear in the thermomechanically affected zone. These fibers were not obviously present in the stir zone, probably due to the intensity of microstructural reformulation to which this region was subjected.

A Comparison of Two Panasonic Lithium-Ion Batteries and Cells for the IBM Thinkpad

NASA Technical Reports Server (NTRS)

Jeevarajan, Judith A.; Cook, Joseph S.; Davies, Francis J.; Collins, Jacob; Bragg, Bobby J.

2003-01-01

The IBM Thinkpad 760XD has been used in the Orbiter and International Space Station since 2000. The Thinkpad is powered by a Panasonic Li-ion battery that has a voltage of 10.8 V and 3.0 Ah capacity. This Thinkpad is now being replaced by the IBM Thinkpad A31P which has a Panasonic Li-ion battery that has a voltage of 10.8 V and 4.0 Ah capacity. Both batteries have protective circuit boards. The Panasonic battery for the Thinkpad 760XD had 12 Panasonic 17500 cells of 0.75 Ah capacity in a 4P3S cOnfiguration. The new Panasonic battery has 6 Panasonic 18650 cells of 2.0 Ah capacity in a 2P3S configuration. The batteries and cells for both models have been evaluated for performance and safety. A comparison of the cells under similar test conditions will be presented. The performance of the cells has been evaluated under different rates of charge and discharge and different temperatures. The cells have been tested under abuse conditions and the safety features in the cells evaluated. The protective circuit board in the battery was also tested under conditions of overcharge, overdischarge, short circuit and unbalanced cell configurations. The results of the studies will be presented in this paper.

Unbalanced neuronal circuits in addiction.

PubMed

Volkow, Nora D; Wang, Gen-Jack; Tomasi, Dardo; Baler, Ruben D

2013-08-01

Through sequential waves of drug-induced neurochemical stimulation, addiction co-opts the brain's neuronal circuits that mediate reward, motivation to behavioral inflexibility and a severe disruption of self-control and compulsive drug intake. Brain imaging technologies have allowed neuroscientists to map out the neural landscape of addiction in the human brain and to understand how drugs modify it. Published by Elsevier Ltd.

Global Views, Personal Perspectives: Connecting to Self as Scholar

ERIC Educational Resources Information Center

Simmons, Nicola

2009-01-01

A global view requires not only a broader perspective, but also greater depth to anchor it firmly. In increasingly changing contexts, are we connected to ourselves in a way that feeds our spirits and nourishes our work? A professional sphere based only on research and practice risks being unbalanced and may jeopardize our well-being as academics.…

Mapping ecological systems with a random foret model: tradeoffs between errors and bias

Treesearch

Emilie Grossmann; Janet Ohmann; James Kagan; Heather May; Matthew Gregory

2010-01-01

New methods for predictive vegetation mapping allow improved estimations of plant community composition across large regions. Random Forest (RF) models limit over-fitting problems of other methods, and are known for making accurate classification predictions from noisy, nonnormal data, but can be biased when plot samples are unbalanced. We developed two contrasting...

The Welfare State and Relative Poverty in Rich Western Democracies, 1967-1997

ERIC Educational Resources Information Center

Brady, David

2005-01-01

This study investigates the relationship between the welfare state and poverty with multiple measures of the welfare state and poverty in an unbalanced panel of 18 Western nations from 1967 to 1997. While addressing the limitations of past research, the analysis shows that social security transfers and public health spending significantly reduce…

Teaching Children To Love: 80 Games & Fun Activities for Raising Balanced Children in Unbalanced Times.

ERIC Educational Resources Information Center

Childre, Doc Lew; Paddison, Sara Hatch, Ed.

Raising children in today's fast-paced society requires love and technique. Ways that parents can teach children to love, teach them values, and help them balance their lives are discussed in this activity book. The text opens with a discussion of heart intelligence (what is sometimes equated with emotional intelligence). Heart intelligence…

All about Motion & Balance. Physical Science for Children[TM]. Schlessinger Science Library. [Videotape].

ERIC Educational Resources Information Center

2000

Walking on a balance beam or riding a bike both require motion and balance. This program will reveal how unbalanced forces create motion, while balanced forces keep things still. Students also learn how concepts like velocity, acceleration, and momentum fit into this puzzle. A unique hands-on activity combined with vivid imagery and graphics…

How Motivation is Learned: A Neurological Explanation. Preconvention Institute 7; Brain Functions in Reading and Reading Disability.

ERIC Educational Resources Information Center

Wilson, John A. R.

If motivation to read fails to develop, reading failure is the outcome. All of us have very delicately balanced neural systems for integrating incoming sensory inputs, evaluating their significance in the light of past experience, and storing the learning for future use. Autistic and hyperkinetic children apparently have unbalanced neurological…

It's a Long Way down: The Underlying Tensions in the Education Export Industry

ERIC Educational Resources Information Center

Marginson, Simon

2011-01-01

The stellar rise of the education export industry in Australian higher education, and the even more spectacular downturn now occurring, mask underlying tensions that have long dogged the industry and prevented it from improving quality or achieving long-term sustainability. The international education programme has been unbalanced by the drive for…

Plant disease severity assessment - How rater bias, assessment method and experimental design affect hypothesis testing and resource use efficiency

USDA-ARS?s Scientific Manuscript database

The impact of rater bias and assessment method on hypothesis testing was studied for different experimental designs for plant disease assessment using balanced and unbalanced data sets. Data sets with the same number of replicate estimates for each of two treatments are termed ‘balanced’, and those ...

Cultural Congruence and Unbalanced Power between Home and School in Rural Ghana and the Impact on School Children

ERIC Educational Resources Information Center

Masko, Amy L.; Bosiwah, Lawrence

2016-01-01

This ethnographic inquiry examines the cultural congruence between home and school in rural Ghana, exploring the cultural norms of child-rearing practices within families and the institution of schooling. The data illustrate both the agreement between home and school in regard to discipline practices and instruction in morality, while…

Bilateral Periventricular Nodular Heterotopia and Lissencephaly in an Infant with Unbalanced t(12;17)(q24.31; p13.3) Translocation

ERIC Educational Resources Information Center

Grosso, Salvatore; Fichera, Marco; Galesi, Ornella; Luciano, Daniela; Pucci, Lucia; Giardini, Francesca; Berardi, Rosario; Balestri, Paolo

2008-01-01

Periventricular nodular heterotopia and Miller-Dieker syndrome are two different disorders of brain development. Miller-Dieker syndrome exhibits classical lissencephaly and is related to defects in the lissencephaly gene ("LIS1"). Periventricular nodular heterotopia is characterized by aggregates of grey matter adjacent to the lateral ventricle…

L[subscript 1] and L[subscript 2] Spoken Word Processing: Evidence from Divided Attention Paradigm

ERIC Educational Resources Information Center

Shafiee Nahrkhalaji, Saeedeh; Lotfi, Ahmad Reza; Koosha, Mansour

2016-01-01

The present study aims to reveal some facts concerning first language (L[subscript 1]) and second language (L[subscript 2]) spoken-word processing in unbalanced proficient bilinguals using behavioral measures. The intention here is to examine the effects of auditory repetition word priming and semantic priming in first and second languages of…

Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial

USDA-ARS?s Scientific Manuscript database

Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity. However, weight loss interventions including dietary calcium or dairy product consumption have not reported changes in lipid metabolism measured by the plasma lipidome. Methods. The objective ...

International Sexual Partnerships May Be Shaped by Sexual Histories and Socioeconomic Status

PubMed Central

Truong, Hong-Ha M.; Mehrotra, Megha; Montoya, Orlando; Lama, Javier R.; Guanira, Juan V.; Casapía, Martín; Veloso, Valdiléa G.; Buchbinder, Susan P.; Mayer, Kenneth H.; Chariyalertsak, Suwat; Schechter, Mauro; Bekker, Linda-Gail; Kallás, Esper G.; Grant, Robert M.

2017-01-01

Exchange sex and higher education were associated with an increased likelihood of international sexual partnerships (ISPs). Exchange sex and older age were associated with an increased likelihood of condomless sex in ISPs. Educational and socioeconomic factors may create unbalanced power dynamics that influence exchange sex and condomless sex in ISPs. PMID:28407648

Literacy Look-Fors: An Observation Protocol to Guide K-6 Classroom Walkthroughs

ERIC Educational Resources Information Center

McEwan-Adkins, Elaine K.

2011-01-01

With all of the reform models, research-based programs, leadership training, and professional development focused on reading and writing, we certainly know more about literacy today than we ever have before. So why are schools still suffering with low literacy levels? The answer lies in ineffective and unbalanced literacy instruction. Through the…

Rural Education and Urbanization: Experiences and Struggles in China since the Late 1970s

ERIC Educational Resources Information Center

Xu, Shuqin; Law, Wing-Wah

2015-01-01

China has adopted an unbalanced policy for economic development to improve its domestic economy and international competitiveness for more than three decades. During this process, rural education has undergone a series of reforms. With reference to compulsory education, this article argues that rural education in China is a pragmatic instrument…

Reciprocity in Intergenerational Support: A Comparison of Chinese and German Adult Daughters

ERIC Educational Resources Information Center

Schwarz, Beate; Trommsdorff, Gisela; Zheng, Gang; Shi, Shaohua

2010-01-01

This study investigates how Chinese and German adult daughters evaluate the norm of reciprocity and the unbalanced exchange of support in relation to their aging parents. Women from rural and urban China (n = 292) and from Germany (n = 264) have participated in this study. Results show that for the German daughters, differently from rural Chinese…

Persistence in the Determination of Work-Related Training Participation: Evidence from the BHPS, 1991-1997

ERIC Educational Resources Information Center

Sousounis, Panos; Bladen-Hovell, Robin

2010-01-01

In this paper we investigate the role of workers' training history in determining current training-incidence. The analysis is conducted on an unbalanced sample comprising information on approximately 5000 employees from the first seven waves of the BHPS. Training participation is modelled as a dynamic random effects probit model where the effects…

Advances in the Applications of Polyhydroxyalkanoate Nanoparticles for Novel Drug Delivery System

PubMed Central

Shrivastav, Anupama; Kim, Hae-Yeong; Kim, Young-Rok

2013-01-01

Drug delivery technology is emerging as an interdisciplinary science aimed at improving human health. The controlled delivery of pharmacologically active agents to the specific site of action at the therapeutically optimal rate and dose regimen has been a major goal in designing drug delivery systems. Over the past few decades, there has been considerable interest in developing biodegradable drug carriers as effective drug delivery systems. Polymeric materials from natural sources play an important role in controlled release of drug at a particular site. Polyhydroxyalkanoates, due to their origin from natural sources, are given attention as candidates for drug delivery materials. Biodegradable and biocompatible polyhydroxyalkanoates are linear polyesters produced by microorganisms under unbalanced growth conditions, which have emerged as potential polymers for use as biomedical materials for drug delivery due to their unique physiochemical and mechanical properties. This review summarizes many of the key findings in the applications of polyhydroxyalkanoates and polyhydroxyalkanoate nanoparticles for drug delivery system. PMID:23984383

Pediatric sample inclusion in an opt-out biorepository linking DNA to de-identified medical records: Pediatric BioVU

PubMed Central

McGregor, Tracy L.; Van Driest, Sara L.; Brothers, Kyle B.; Bowton, Erica A.; Muglia, Louis J.; Roden, Dan M.

2013-01-01

The Vanderbilt DNA repository, BioVU, links DNA from leftover clinical blood samples to de-identified electronic medical records. After initiating adult sample collection, pediatric extension required consideration of ethical concerns specific to pediatrics and implementation of specialized DNA extraction methods. In the first year of pediatric sample collection, over 11,000 samples were included from individuals younger than 18 years. We compared the pediatric BioVU cohort to the overall Vanderbilt University Medical Center pediatric population and found similar demographic characteristics; however, the BioVU cohort has higher rates of select diseases, medication exposures, and laboratory testing, demonstrating enriched representation of severe or chronic disease. This unbalanced sample accumulation may accelerate research of some cohorts, but also may limit study of relatively benign conditions and the accrual of unaffected and unbiased control samples. BioVU represents a feasible model for pediatric DNA biobanking but involves both ethical and practical considerations specific to the pediatric population. PMID:23281421

Hazards Due to Overdischarge in Lithium-ion Cylindrical Cells in Multi-cell Configurations

NASA Technical Reports Server (NTRS)

Jeevarajan, Judith; Strangways, Brad; Nelson, Tim

2010-01-01

Lithium-ion cells in the cylindrical Commercial-off-the-shelf 18650 design format were used to study the hazards associated with overdischarge. The cells in series or in parallel configurations were subjected to different conditions of overdischarge. The cells in parallel configurations were all overdischarged to 2.0 V for 75 cycles with one cell removed at 25 cycles to study the health of the cell. The cells in series were designed to be in an unbalanced configuration by discharging one cell in each series configuration before the start of test. The discharge consisted of removing a pre-determined capacity from the cell. This ranged from 50 to 150 mAh removal. The cells were discharged down to a predetermined end-of-discharge voltage cutoff which allowed the cell with lower capacity to go into an overdischarge mode. The cell modules that survived the 75 cycles were subjected to one overvoltage test to 4.4 V/cell.

Effects of Double Transgenesis of Somatotrophic Axis (GH/GHR) on Skeletal Muscle Growth of Zebrafish (Danio rerio).

PubMed

Silva, Ana Cecilia Gomes; Almeida, Daniela Volcan; Nornberg, Bruna Felix; Figueiredo, Marcio Azevedo; Romano, Luis Alberto; Marins, Luis Fernando

2015-12-01

Transgenic fish for growth hormone (GH) has been considered as a potential technological improvement in aquaculture. In this study, a double-transgenic zebrafish was used to evaluate the effect of GH and its receptor (GHR) on muscle growth. Double transgenics reached the same length of GH transgenic, but with significantly less weight, featuring an unbalanced growth. The condition factor of GH/GHR-transgenic fish was lower than the other genotypes. Histological analysis showed a decrease in the percentage of thick muscle fibers in GH/GHR genotype of ∼ 80% in comparison to GH-transgenic line. The analysis of gene expression showed a significant decrease in genes related to muscle growth in GH/GHR genotype. It seems that concomitant overexpression of GH and GHR resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1 (STAT5.1).

Suppression of Neutrophil-Mediated Tissue Damage—A Novel Skill of Mesenchymal Stem Cells

PubMed Central

Jiang, Dongsheng; Muschhammer, Jana; Qi, Yu; Kügler, Andrea; De Vries, Juliane C.; Saffarzadeh, Mona; Sindrilaru, Anca; Beken, Seppe Vander; Wlaschek, Meinhard; Kluth, Mark A.; Ganss, Christoph; Frank, Natasha Y.; Frank, Markus H.; Preissner, Klaus T.; Scharffetter-Kochanek, Karin

2017-01-01

Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and regeneration. Though of prime interest, their potentially protective role on neutrophil-induced tissue damage, associated with high morbidity and mortality, has not been explored in sufficient detail. Here we report the therapeutic skill of MSCs to suppress unrestrained neutrophil activation and to attenuate severe tissue damage in a murine immune-complex mediated vasculitis model of unbalanced neutrophil activation. MSC-mediated neutrophil suppression was due to intercellular adhesion molecule 1-dependent engulfment of neutrophils by MSCs, decreasing overall neutrophil numbers. Similar to MSCs in their endogenous niche of murine and human vasculitis, therapeutically injected MSCs via upregulation of the extracellular superoxide dismutase (SOD3), reduced super-oxide anion concentrations and consequently prevented neutrophil death, neutrophil extracellular trap formation and spillage of matrix degrading neutrophil elastase, gelatinase and myeloperoxidase. SOD3-silenced MSCs did not exert tissue protective effects. Thus, MSCs hold substantial therapeutic promise to counteract tissue damage in conditions with unrestrained neutrophil activation. PMID:27299700

Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome.

PubMed

Febo, Marcelo; Blum, Kenneth; Badgaiyan, Rajendra D; Baron, David; Thanos, Panayotis K; Colon-Perez, Luis M; Demortrovics, Zsolt; Gold, Mark S

2017-01-01

Reward deficiency syndrome (RDS) was first proposed by Kenneth Blum in 1995 to provide a clinically relevant and predictive term for conditions involving deficits in mesocorticolimbic dopamine function. Genetic, molecular, and neuronal alterations in key components of this circuitry contribute to a reward deficit state that can drive drug-seeking, consumption, and relapse. Among the dysfunctions observed in RDS are dysregulated resting state networks, which recently have been assessed in detail in chronic drug users by, positron emission tomography, functional magnetic resonance imaging, and functional connectivity analysis. A growing number of studies are helping to determine the putative roles of dopamine and glutamatergic neurotransmission in the regulation of activity in resting state networks, particularly in brain reward circuitry affected in drug use disorders. Indeed, we hypothesize in the present review that loss of homeostasis of these systems may lead to 'unbalanced' functional networks that might be both cause and outcome of disrupted synaptic communication between cortical and subcortical systems essential for controlling reward, emotional control, sensation seeking, and chronic drug use.

Active Vibration Reduction of the Advanced Stirling Convertor

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Metscher, Jonathan F.; Schifer, Nicholas A.

2016-01-01

Stirling Radioisotope Power Systems (RPS) are being developed as an option to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove. A Stirling Radioisotope Generator (SRG) could offer space missions a more efficient power system that uses one fourth of the nuclear fuel and decreases the thermal footprint compared to the current state of the art. The Stirling Cycle Technology Development (SCTD) Project is funded by the RPS Program to developing Stirling-based subsystems, including convertors and controller maturation efforts that have resulted in high fidelity hardware like the Advanced Stirling Radioisotope Generator (ASRG), Advanced Stirling Convertor (ASC), and ASC Controller Unit (ACU). The SCTD Project also performs research to develop less mature technologies with a wide variety of objectives, including increasing temperature capability to enable new environments, improving system reliability or fault tolerance, reducing mass or size, and developing advanced concepts that are mission enabling. Active vibration reduction systems (AVRS), or "balancers", have historically been developed and characterized to provide fault tolerance for generator designs that incorporate dual-opposed Stirling convertors or enable single convertor, or small RPS, missions. Balancers reduce the dynamic disturbance forces created by the power piston and displacer internal moving components of a single operating convertor to meet spacecraft requirements for induced disturbance force. To improve fault tolerance for dual-opposed configurations and enable single convertor configurations, a breadboard AVRS was implemented on the Advanced Stirling Convertor (ASC). The AVRS included a linear motor, a motor mount, and a closed-loop controller able to balance out the transmitted peak dynamic disturbance using acceleration feedback. Test objectives included quantifying power and mass penalty and reduction in transmitted force over a range of ASC operating parameters and mounting conditions. All tests were performed at three different piston amplitudes, 3.0 mm, 3.75 mm, and 4.5 mm. Overall, the transmitted force was reduced to 2% of the total unbalanced force by actively balancing out only the first fundamental frequency, with balancer motor power remaining under one watt. The test results will be used to guide future balancer designs.

Active Vibration Reduction of the Advanced Stirling Convertor

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Metscher, Jonathan F.; Schifer, Nicholas A.

2016-01-01

Stirling Radioisotope Power Systems (RPS) are being developed as an option to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove. A Stirling Radioisotope Generator (SRG) could offer space missions a more efficient power system that uses one fourth of the nuclear fuel and decreases the thermal footprint compared to the current state of the art. The Stirling Cycle Technology Development (SCTD) Project is funded by the RPS Program to developing Stirling-based subsystems, including convertors and controller maturation efforts that have resulted in high fidelity hardware like the Advanced Stirling Radioisotope Generator (ASRG), Advanced Stirling Convertor (ASC), and ASC Controller Unit (ACU). The SCTD Project also performs research to develop less mature technologies with a wide variety of objectives, including increasing temperature capability to enable new environments, improving system reliability or fault tolerance, reducing mass or size, and developing advanced concepts that are mission enabling. Active vibration reduction systems (AVRS), or "balancers", have historically been developed and characterized to provide fault tolerance for generator designs that incorporate dual-opposed Stirling convertors or enable single convertor, or small RPS, missions. Balancers reduce the dynamic disturbance forces created by the power piston and displacer internal moving components of a single operating convertor to meet spacecraft requirements for induced disturbance force. To improve fault tolerance for dual-opposed configurations and enable single convertor configurations, a breadboard AVRS was implemented on the Advanced Stirling Convertor (ASC). The AVRS included a linear motor, a motor mount, and a closed-loop controller able to balance out the transmitted peak dynamic disturbance using acceleration feedback. Test objectives included quantifying power and mass penalty and reduction in transmitted force over a range of ASC operating parameters and mounting conditions. All tests were performed at three different piston amplitudes, 3.0, 3.75, and 4.5 mm. Overall, the transmitted force was reduced to 2 percent of the total unbalanced force by actively balancing out only the first fundamental frequency, with balancer motor power remaining under 1 watt. The test results will be used to guide future balancer designs.

Cooling the dark energy camera instrument

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitt, R.L.; Cease, H.; /Fermilab

2008-06-01

DECam, camera for the Dark Energy Survey (DES), is undergoing general design and component testing. For an overview see DePoy, et al in these proceedings. For a description of the imager, see Cease, et al in these proceedings. The CCD instrument will be mounted at the prime focus of the CTIO Blanco 4m telescope. The instrument temperature will be 173K with a heat load of 113W. In similar applications, cooling CCD instruments at the prime focus has been accomplished by three general methods. Liquid nitrogen reservoirs have been constructed to operate in any orientation, pulse tube cryocoolers have been usedmore » when tilt angles are limited and Joule-Thompson or Stirling cryocoolers have been used with smaller heat loads. Gifford-MacMahon cooling has been used at the Cassegrain but not at the prime focus. For DES, the combined requirements of high heat load, temperature stability, low vibration, operation in any orientation, liquid nitrogen cost and limited space available led to the design of a pumped, closed loop, circulating nitrogen system. At zenith the instrument will be twelve meters above the pump/cryocooler station. This cooling system expected to have a 10,000 hour maintenance interval. This paper will describe the engineering basis including the thermal model, unbalanced forces, cooldown time, the single and two-phase flow model.« less

Soft tissue balancing in total knee arthroplasty using sensor-guided assessment: is there a learning curve?

PubMed

Gharaibeh, Monther A; Chen, Darren B; MacDessi, Samuel J

2018-05-01

Sensor-guided assessment for soft tissue balance in total knee arthroplasty (TKA) has been reported to improve patient satisfaction and self-reported outcome scores. As more surgeons adopt this technology in TKA, we performed this study to identify if there is a learning curve with its use. Analysis of a total of 90 consecutive cases was performed in this study. Initial and final intercompartmental pressure differences were recorded before and after knee ligament balancing. The first 45 patients (group 1) were compared to the last 45 patients (group 2) in terms of operative time and the final state of knee balance. A balanced knee was defined as pressure difference between medial and lateral compartments of ≤15 pounds. Group 1 had 10 unbalanced knees in the final pressure difference assessment, while all cases in group 2 were balanced (P < 0.001). There was no statistically significant difference in mean operative time between the two groups. A scatter plot of intercompartmental pressure difference identified that after 30 cases, the capacity to achieve knee ligament balance improved. This study suggests that there is a learning curve with the use of sensor-guided assessment in TKA in achieving knee balance; however, the differences noted between initial and final groups were small and may not be of clinical significance. © 2018 Royal Australasian College of Surgeons.

Nonlinear intermodulation distortion suppression in coherent analog fiber optic link using electro-optic polymeric dual parallel Mach-Zehnder modulator.

PubMed

Kim, Seong-Ku; Liu, Wei; Pei, Qibing; Dalton, Larry R; Fetterman, Harold R

2011-04-11

A linearized dual parallel Mach-Zehnder modulator (DPMZM) based on electro-optic (EO) polymer was both fabricated, and experimentally used to suppress the third-order intermodulation distortion (IMD3) in a coherent analog fiber optic link. This optical transmitter design was based on a new EO chromophore called B10, which was synthesized for applications dealing with the fiber-optic communication systems. The chromophore was mixed with amorphous polycarbonate (APC) to form the waveguide's core material. The DPMZM was configured with two MZMs, of different lengths in parallel, with unbalanced input and output couplers and a phase shifter in one arm. In this configuration each of the MZMs carried a different optical power, and imposed a different depth of optical modulation. When the two optical beams from the MZMs were combined to generate the transmitted signal it was possible to set the IMD3 produced by each modulator to be equal in amplitude but 180° out of phase from the other. Therefore, the resulting IMD3 of the DPMZM transmitter was effectively canceled out during two-tone experiments. A reduction of the IMD3 below the noise floor was observed while leaving fifth-order distortion (IMD5) as the dominant IMD product. This configuration has the capability of broadband operation and shot-noise limited operation simultaneously. © 2011 Optical Society of America

Important parameters affecting the cell voltage of aqueous electrical double-layer capacitors

NASA Astrophysics Data System (ADS)

Wu, Tzu-Ho; Hsu, Chun-Tsung; Hu, Chi-Chang; Hardwick, Laurence J.

2013-11-01

This study discusses and demonstrates how the open-circuit potential and charges stored in the working potential window on positive and negative electrodes affect the cell voltage of carbon-based electrical double-layer capacitors (EDLCs) in aqueous electrolytes. An EDLC consisting of two activated carbon electrodes is employed as the model system for identifying these key parameters although the potential window of water decomposition can be simply determined by voltammetric methods. First, the capacitive performances of an EDLC with the same charge on positive and negative electrodes are evaluated by cyclic voltammetric, charge-discharge, electrochemical impedance spectroscopic (EIS) analyses, and inductance-capacitance-resistance meter (LCR meter). The principles for obtaining the highest acceptable cell voltage of such symmetric ECs with excellent reversibility and capacitor-like behaviour are proposed. Aqueous charge-balanced EDLCs can be operated as high as 2.0 V with high energy efficiency (about 90%) and only 4% capacitance loss after the 600-cycle stability checking. The necessity of charge balance (but not capacitance balance) for positive and negative electrodes is substantiated from the lower acceptable cell voltage of charge-unbalanced EDLCs.

Vibration detection of component health and operability

NASA Technical Reports Server (NTRS)

Baird, B. C.

1975-01-01

In order to prevent catastrophic failure and eliminate unnecessary periodic maintenance in the shuttle orbiter program environmental control system components, some means of detecting incipient failure in these components is required. The utilization was investigated of vibrational/acoustic phenomena as one of the principal physical parameters on which to base the design of this instrumentation. Baseline vibration/acoustic data was collected from three aircraft type fans and two aircraft type pumps over a frequency range from a few hertz to greater than 3000 kHz. The baseline data included spectrum analysis of the baseband vibration signal, spectrum analysis of the detected high frequency bandpass acoustic signal, and amplitude distribution of the high frequency bandpass acoustic signal. A total of eight bearing defects and two unbalancings was introduced into the five test items. All defects were detected by at least one of a set of vibration/acoustic parameters with a margin of at least 2:1 over the worst case baseline. The design of a portable instrument using this set of vibration/acoustic parameters for detecting incipient failures in environmental control system components is described.

How soil moisture mediates the influence of transpiration on streamflow at hourly to interannual scales in a forested catchment

Treesearch

G.W. Moore; J.A. Jones; B.J. Bond

2011-01-01

The water balance equation dictates that streamflow may be reduced by transpiration. Yet temporal disequilibrium weakens the relationship between transpiration and streamflow in many cases where inputs and outputs are unbalanced. We address two critical knowledge barriers in ecohydrology with respect to time, scale dependence and lags. Study objectives were to...

The Interrelatedness of Affective Factors in EFL Learning: An Examination of Motivational Patterns in Relation to Anxiety in China

ERIC Educational Resources Information Center

Wei, Ming

2007-01-01

This study examines the motivational pattern in relation to the anxiety of Chinese learners of English. Based on a survey consisting of an anxiety questionnaire and a motivation questionnaire, the findings revealed an unbalanced pattern of two types of motivation clusters that resembled the integrative-instrumental duality, with the level of…

Balanced and Unbalanced Aspects of Tropical Cyclone Intensification

DTIC Science & Technology

2009-10-06

axisymmetric balance theory. The secondary ( overturning ) circulation and balanced tendency for the primary circulation are obtained by solving a...balance theory. The secondary ( overturning ) circulation and balanced tendency for the primary circulation are obtained by solving a general form of the... meridional circulation . This equation is often referred to as the Sawyer–Eliassen (SE) equation (Willoughby, 1979; Shapiro and Willoughby, 1982). For

Bilingualism and Attention: A Study of Balanced and Unbalanced Bilingual Deaf Users of American Sign Language and English

ERIC Educational Resources Information Center

Kushalnagar, Poorna; Hannay, H. Julia; Hernandez, Arturo E.

2010-01-01

Early deafness is thought to affect low-level sensorimotor processing such as selective attention, whereas bilingualism is thought to be strongly associated with higher order cognitive processing such as attention switching under cognitive load. This study explores the effects of bimodal-bilingualism (in American Sign Language and written English)…

Excursive behaviors by female white-tailed deer during estrus at two mid-Atlantic sites

Treesearch

Jeffrey J. Kolodzinski; Lawrence V. Tannenbaum; Lisa I. Muller; David A. Osborn; Kent A. Adams; Mark C. Conner; W. Mark Ford; Karl V. Miller

2010-01-01

Current research suggests that female white-tailed deer (Odocoileus virginianus) will adopt sedentary breeding strategies in populations with an abundance of males and a more active mate-searching strategy in low-density or unbalanced herds. We used GPS collars to document the movements of 10 female deer during the breeding season at two Mid-Atlantic...

Modeling the Psychometric Properties of Complex Performance Assessment Tasks Using Confirmatory Factor Analysis: A Multistage Model for Calibrating Tasks

ERIC Educational Resources Information Center

Kahraman, Nilufer; De Champlain, Andre; Raymond, Mark

2012-01-01

Item-level information, such as difficulty and discrimination are invaluable to the test assembly, equating, and scoring practices. Estimating these parameters within the context of large-scale performance assessments is often hindered by the use of unbalanced designs for assigning examinees to tasks and raters because such designs result in very…

Masked Translation Priming Effects in Visual Word Recognition by Trilinguals

ERIC Educational Resources Information Center

Aparicio, Xavier; Lavaur, Jean-Marc

2016-01-01

The present study aims to investigate how trilinguals process their two non-dominant languages and how those languages influence one another, as well as the relative importance of the dominant language on their processing. With this in mind, 24 French (L1)- English (L2)- and Spanish (L3)-unbalanced trilinguals, deemed equivalent in their L2 and L3…

Cutting strategies and timber yields for unbalanced even-aged northern hardwood forests

Treesearch

William B. Leak; Stanley M. Filip; Stanley M. Filip

1970-01-01

The even-aged hardwood forest, with a poorly balanced distribution of age-classes, can cause perplexing problems during the first rotation. What is the best cutting strategy to follow? By using linear programming, we developed some cutting strategies that maximize board-foot production and produce a balanced age distribution by the end of the first rotation. We...

Altitude valve for railway suspension control system

NASA Astrophysics Data System (ADS)

Zhang, Xuan; Zhang, Lihao; Li, Qingxuan; Chen, WanSong

2017-09-01

With the variation of people and material during vehicle service, the gravity of vehicle could be unbalanced. As a result it might cause accident. In order to solve this problem, altitude valve is assembled on board. It can adjust the gravity of vehicle by the intake and outlet progress of the spring in the altitude valve to prevent the tilt of vehicles.

Characterization of two familial cases presenting with a syndromic specific learning disorder and carrying (17q;21q) unbalanced translocations.

PubMed

Coton, Julie; Labalme, Audrey; Till, Marianne; Bussy, Gerald; Krifi Papoz, Sonia; Lesca, Gaetan; Heron, Delphine; Sanlaville, Damien; Edery, Patrick; des Portes, Vincent; Rossi, Massimiliano

2018-05-01

Chromosomal microarray (CMA) can detect pathogenic copy number variations in 15-20% of individuals with intellectual disability and in 10% of patients with autism spectrum disorders. The diagnostic rate in specific learning disorders (SLD) is unknown. Our study emphasizes the usefulness of CMA in the diagnostic workout assessment of familial SLD.

The Detrimental Effects of Social Capital on the Balanced Development of Compulsory Education and Their Governance

ERIC Educational Resources Information Center

Zhang, Dongjiao

2009-01-01

The balanced development of compulsory education, with a focus on the goal of educational equality, is both a matter of policy orientation and a practical educational issue. At present, people are mostly concerned with the unbalanced state of development of compulsory education, its causes, and issues regarding its administration. Various modes of…

Evaluating Model Fit for Growth Curve Models: Integration of Fit Indices from SEM and MLM Frameworks

ERIC Educational Resources Information Center

Wu, Wei; West, Stephen G.; Taylor, Aaron B.

2009-01-01

Evaluating overall model fit for growth curve models involves 3 challenging issues. (a) Three types of longitudinal data with different implications for model fit may be distinguished: balanced on time with complete data, balanced on time with data missing at random, and unbalanced on time. (b) Traditional work on fit from the structural equation…

76 FR 45638 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-29

... the TPR, an industry group formed and sponsored by the Federal Reserve Bank of New York.\\5\\ Because... that GSCC would likely have unbalanced net GCF securities and cash positions within each clearing bank... clearing bank will be net funds borrowers, while the dealers at the other clearing bank will be net funds...

Second-Class, Cash Strapped, Antiquated Institutions: Unbalanced Media Depictions of Historically Black Colleges and Universities in the "Chronicle of Higher Education"

ERIC Educational Resources Information Center

Waymer, Damion; Street, Joshua

2016-01-01

Purpose: The purpose of this paper is to examine "The Chronicle of Higher Education", a leading site for higher education news and politics, and its representation of historically black colleges and universities (HBCUs). Design/methodology/approach: Frames are strong discursive tools that can help social actors achieve the following:…

Bilingual Word Recognition in Deaf and Hearing Signers: Effects of Proficiency and Language Dominance on Cross-Language Activation

ERIC Educational Resources Information Center

Morford, Jill P.; Kroll, Judith F.; Piñar, Pilar; Wilkinson, Erin

2014-01-01

Recent evidence demonstrates that American Sign Language (ASL) signs are active during print word recognition in deaf bilinguals who are highly proficient in both ASL and English. In the present study, we investigate whether signs are active during print word recognition in two groups of unbalanced bilinguals: deaf ASL-dominant and hearing…

The evaluation of shear deformation for contact analysis with large displacement

NASA Astrophysics Data System (ADS)

Nizam, Z. M.; Obiya, H.; Ijima, K.; Azhar, A. T. S.; Hazreek, Z. A. M.; Shaylinda, M. Z. N.

2018-04-01

A common problem encountered in the study of contact problem is the failure to obtain stable and accurate convergence result when the contact node is close to the element edge, which is referred as “critical area”. In previous studies, the modification of the element force equation to apply it to a node-element contact problem using the Euler-Bernoulli beam theory [1]. A simple single-element consists two edges and a contact point was used to simulate contact phenomenon of a plane frame. The modification was proven to be effective by the converge-ability of the unbalanced force at the tip of element edge, which enabled the contact node to “pass-through”, resulting in precise results. However, in another recent study, we discover that, if shear deformation based on Timoshenko beam theory is taken into consideration, a basic simply supported beam coordinate afforded a much simpler and more efficient technique for avoiding the divergence of the unbalanced force in the “critical area”. Using our unique and robust Tangent Stiffness Method, the improved equation can be used to overcome any geometrically nonlinear analyses, including those involving extremely large displacements.

Radiomics-based Prognosis Analysis for Non-Small Cell Lung Cancer

NASA Astrophysics Data System (ADS)

Zhang, Yucheng; Oikonomou, Anastasia; Wong, Alexander; Haider, Masoom A.; Khalvati, Farzad

2017-04-01

Radiomics characterizes tumor phenotypes by extracting large numbers of quantitative features from radiological images. Radiomic features have been shown to provide prognostic value in predicting clinical outcomes in several studies. However, several challenges including feature redundancy, unbalanced data, and small sample sizes have led to relatively low predictive accuracy. In this study, we explore different strategies for overcoming these challenges and improving predictive performance of radiomics-based prognosis for non-small cell lung cancer (NSCLC). CT images of 112 patients (mean age 75 years) with NSCLC who underwent stereotactic body radiotherapy were used to predict recurrence, death, and recurrence-free survival using a comprehensive radiomics analysis. Different feature selection and predictive modeling techniques were used to determine the optimal configuration of prognosis analysis. To address feature redundancy, comprehensive analysis indicated that Random Forest models and Principal Component Analysis were optimum predictive modeling and feature selection methods, respectively, for achieving high prognosis performance. To address unbalanced data, Synthetic Minority Over-sampling technique was found to significantly increase predictive accuracy. A full analysis of variance showed that data endpoints, feature selection techniques, and classifiers were significant factors in affecting predictive accuracy, suggesting that these factors must be investigated when building radiomics-based predictive models for cancer prognosis.

Genetic counseling in adult carriers of a balanced chromosomal rearrangement ascertained in childhood: experiences from a nationwide reexamination of translocation carriers.

PubMed

Bache, Iben; Brondum-Nielsen, Karen; Tommerup, Niels

2007-03-01

Prenatal diagnosis is offered to carriers of a balanced chromosomal rearrangement because it may predispose to offspring with an unbalanced karyotype. Therefore, carriers examined prenatally or in childhood should be informed before they reach reproductive age. We aimed to determine how many of the adult carriers ascertained in childhood currently know about their carrier status. We used data obtained by a questionnaire study reexamining carriers of a balanced reciprocal translocation. When a carrier was older than 18 years of age and had been examined in childhood, relatives were asked whether she/he knew of the translocation. Among the 113 parents we interviewed, 10 carriers (9%) in 8 families had not been informed. In one of the eight families, an offspring with an unbalanced translocation was born 23 years after the father had been examined in childhood. Because of our findings, the practice of genetic counseling in Denmark has been changed: When a carrier of a balanced chromosomal rearrangement who was examined prenatally or in childhood turns 18 years of age, the parents will receive a letter reminding the family about the reproductive risk.

In favor of general probability distributions: lateral prefrontal and insular cortices respond to stimulus inherent, but irrelevant differences.

PubMed

Mestres-Missé, Anna; Trampel, Robert; Turner, Robert; Kotz, Sonja A

2016-04-01

A key aspect of optimal behavior is the ability to predict what will come next. To achieve this, we must have a fairly good idea of the probability of occurrence of possible outcomes. This is based both on prior knowledge about a particular or similar situation and on immediately relevant new information. One question that arises is: when considering converging prior probability and external evidence, is the most probable outcome selected or does the brain represent degrees of uncertainty, even highly improbable ones? Using functional magnetic resonance imaging, the current study explored these possibilities by contrasting words that differ in their probability of occurrence, namely, unbalanced ambiguous words and unambiguous words. Unbalanced ambiguous words have a strong frequency-based bias towards one meaning, while unambiguous words have only one meaning. The current results reveal larger activation in lateral prefrontal and insular cortices in response to dominant ambiguous compared to unambiguous words even when prior and contextual information biases one interpretation only. These results suggest a probability distribution, whereby all outcomes and their associated probabilities of occurrence--even if very low--are represented and maintained.

Upper Ocean Meso-Submesoscale Eddy Variability in the Northwestern Pacific from Repeat ADCP Measurements and 1/48-deg MITgcm Simulation

NASA Astrophysics Data System (ADS)

Qiu, B.; Nakano, T.; Chen, S.; Wang, J.; Fu, L. L.; Klein, P.

2016-12-01

With the use of Ka-band radar interferometry, the Surface Water and Ocean Topography (SWOT) satellite will improve the measured sea surface height (SSH) resolution down to the spectral wavelength of 15km, allowing us to investigate for the first time the upper oceancirculation variability at the submesoscale range on the global scale. By analyzing repeat shipboardAcoustic Doppler Current Profiler (ADCP) measurements along 137°E, as well as the 1/48-deg MITgcm simulation output, in the northwest Pacific, we demonstrate that the observed/modeled upper ocean velocities are comprised of balanced geostrophic motions and unbalanced ageostrophic wave motions. The length scale, Lc, that separates the dominance between these two types of motions is found to depend sensitively on the energy level of local mesoscale eddy variability. In the eddy-abundant western boundary current region of Kuroshio, Lc can be shorter than 15km, whereas Lc exceeds 200km along the path of relatively stable North Equatorial Current. Judicious separation between the balanced and unbalanced surface ocean signals will both be a challenge and opportunity for the SWOT mission.

De novo unbalanced translocation resulting in monosomy for proximal 14q and distal 4p in a fetus with intrauterine growth retardation, Wolf-Hirschhorn syndrome, hypertrophic cardiomyopathy, and partial hemihypoplasia.

PubMed

Chen, C P; Chern, S R; Lee, C C; Chen, W L; Chen, M H; Chang, K M

1998-12-01

We present the perinatal findings of a fetus with a de novo unbalanced chromosome translocation that resulted in monosomy for proximal 14q and monosomy for distal 4p. Prenatal sonographic examination at 27 weeks of gestation showed intrauterine growth retardation, microcephaly, cardiomegaly with arrhythmia, and asymmetry of the upper limbs. Genetic amniocentesis showed an abnormal karyotype of 45,XX,der(4)t(4;14)(p16.3;q12),-14. Linkage analysis of the family confirmed the maternal origin of the deletions. Molecular refinement of the deletion breakpoints indicated that the breakpoints at 4p16.3 and 14q12 were located between loci D4S403 (present) and D4S394 (absent), and between loci D14S252 (present) and D14S64 (absent), respectively. Necropsy showed dysmorphic features compatible with Wolf-Hirschhorn syndrome, hypertrophic cardiomyopathy, partial hemihypoplasia, and a normal brain without evidence of holoprosencephaly. Our case adds to the list of clinical phenotypes associated with the proximal regions of 14q.

Wolf-Hirschhorn Syndrome with Epibulbar Dermoid: An Unusual Association in a Patient with 4p Deletion and Functional Xp Disomy.

PubMed

Bragagnolo, Silvia; Colovati, Mileny E S; Guilherme, Roberta S; Dantas, Anelisa G; de Souza, Malú Zamariolli; de Soares, Maria F; Melaragno, Maria I; Perez, Ana B

2016-01-01

Wolf-Hirschhorn syndrome (WHS) is a contiguous gene and multiple malformation syndrome that results from a deletion in the 4p16.3 region. We describe here a 6-month-old girl that presented with WHS features but also displayed unusual findings, such as epibulbar dermoid in the left eye, ear tags, and left microtia. Although on G-banding her karyotype appeared to be normal, chromosomal microarray analysis revealed an ∼13-Mb 4p16.3p15.33 deletion and an ∼9-Mb Xp22.33p22.31 duplication, resulting from a balanced maternal t(X;4)(p22.31;p15.33) translocation. The patient presented with functional Xp disomy due to an unbalanced X-autosome translocation, a rare cytogenetic finding in females with unbalanced rearrangements. Sequencing of both chromosome breakpoints detected no gene disruption. To the best of our knowledge, this is the first patient described in the literature with WHS and epibulbar dermoid, a typical characteristic of the oculoauriculovertebral spectrum (OAVS). Our data suggest that possible candidate genes for OAVS may have been deleted along with the WHS critical region. © 2016 S. Karger AG, Basel.

A Rare Combination of Functional Disomy Xp, Deletion Xq13.2-q28 Spanning the XIST Gene, and Duplication 3q25.33-q29 in a Female with der(X)t(X;3)(q13.2;q25.33).

PubMed

Peterson, Jess F; Basel, Donald G; Bick, David P; Chirempes, Brett; Lorier, Rachel B; Zemlicka, Nykula; Grignon, John W; Weik, LuAnn; Kappes, Ulrike

2018-03-01

We report a 19-year-old female patient with a history of short stature, primary ovarian insufficiency, sensorineural hearing loss, sacral teratoma, neurogenic bladder, and intellectual disability with underlying mosaicism for der(X)t(X;3)(q13.2;q25.33), a ring X chromosome, and monosomy X. Derivative X chromosomes from unbalanced X-autosomal translocations are preferentially silenced by the XIST gene (Xq13.2) located within the X-inactivation center. The unbalanced X-autosomal translocation in our case resulted in loss of the XIST gene thus precluding the inactivation of the derivative X chromosome. As a result, clinical features of functional disomy Xp, Turner's syndrome, and duplication 3q syndrome were observed. Importantly, indications of the derivative X chromosome were revealed by microarray analysis following an initial diagnosis of Turner's syndrome made by conventional cytogenetic studies approximately 18 months earlier. This case demonstrates the importance of utilizing microarray analysis as a first-line test in patients with clinical features beyond the scope of a well-defined genetic syndrome.

Short-Exponent RSA

NASA Astrophysics Data System (ADS)

Sun, Hung-Min; Yang, Cheng-Ta; Wu, Mu-En

In some applications, a short private exponent d is chosen to improve the decryption or signing process for RSA public key cryptosystem. However, in a typical RSA, if the private exponent d is selected first, the public exponent e should be of the same order of magnitude as φ(N). Sun et al. devised three RSA variants using unbalanced prime factors p and q to lower the computational cost. Unfortunately, Durfee & Nguyen broke the illustrated instances of the first and third variants by solving small roots to trivariate modular polynomial equations. They also indicated that the instances with unbalanced primes p and q are more insecure than the instances with balanced p and q. This investigation focuses on designing a new RSA variant with balanced p and q, and short exponents d and e, to improve the security of an RSA variant against the Durfee & Nguyen's attack, and the other existing attacks. Furthermore, the proposed variant (Scheme A) is also extended to another RSA variant (Scheme B) in which p and q are balanced, and a trade-off between the lengths of d and e is enable. In addition, we provide the security analysis and feasibility analysis of the proposed schemes.

Improving optical properties of silicon nitride films to be applied in the middle infrared optics by a combined high-power impulse/unbalanced magnetron sputtering deposition technique.

PubMed

Liao, Bo-Huei; Hsiao, Chien-Nan

2014-02-01

Silicon nitride films are prepared by a combined high-power impulse/unbalanced magnetron sputtering (HIPIMS/UBMS) deposition technique. Different unbalance coefficients and pulse on/off ratios are applied to improve the optical properties of the silicon nitride films. The refractive indices of the Si3N4 films vary from 2.17 to 2.02 in the wavelength ranges of 400-700 nm, and all the extinction coefficients are smaller than 1×10(-4). The Fourier transform infrared spectroscopy and x-ray diffractometry measurements reveal the amorphous structure of the Si3N4 films with extremely low hydrogen content and very low absorption between the near IR and middle IR ranges. Compared to other deposition techniques, Si3N4 films deposited by the combined HIPIMS/UBMS deposition technique possess the highest refractive index, the lowest extinction coefficient, and excellent structural properties. Finally a four-layer coating is deposited on both sides of a silicon substrate. The average transmittance from 3200 to 4800 nm is 99.0%, and the highest transmittance is 99.97% around 4200 nm.

Carbon film deposition on SnO{sub 2}/Si(111) using DC unbalanced magnetron sputtering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aji, A. S.; Darma, Y.

In this paper, carbon deposition on SnO{sub 2} layer using DC unbalanced magnetron-sputtering technique at low temperature has been systematically studied. Sputtering process were carried out at pressure of 4.6×10{sup −2} Torr by keeping the substrate temperature at 300 °C. SnO{sub 2} were growth on silicon (111) substrate using thermal evaporation and continuing with dry oxidation of Sn at 225 °C. Thermal evaporation for high purity Sn was conducted by maintain the current source as high as 40 ampere. The quality of SnO{sub 2} on Si(111) and the characteristic of carbon thin film on SnO{sub 2} were analized by meanmore » XRD, FTIR and Raman spectra. XRD analysis shows that SnO{sub 2} film is growth uniformly on Si(111). FTIR and Raman spectra confirm the formation of thin film carbon on SnO{sub 2}. Additionally, thermal annealing for some sample series have been performed to study their structural stability. The change of atomic structure due to thermal annealing were analized by Raman and XRD spectra.« less

Can Characteristics of Reciprocal Translocations Predict the Chance of Transferable Embryos in PGD Cycles?

PubMed Central

Dul, Elsbeth; van Echten-Arends, Jannie; Groen, Henk; Kastrop, Peter; Amory-van Wissen, Lucie; Engelen, John; Land, Jolande; Coonen, Edith; van Ravenswaaij-Arts, Conny

2014-01-01

Translocation carriers have an increased risk of miscarriage or the birth of a child with congenital anomalies. Preimplantation genetic diagnosis (PGD) is performed in translocation carriers to select for balanced embryos and, thus, increase the chance of an ongoing pregnancy. However, a common experience is that reciprocal translocation carriers produce a high percentage of unbalanced embryos, which cannot be transferred. Therefore, the pregnancy rates in PGD in this patient group are low. In a cohort of 85 reciprocal translocation carriers undergoing PGD we have searched for cytogenetic characteristics of the translocations that can predict the percentage of balanced embryos. Using shape algorithms, the most likely segregation mode per translocation was determined. Shape algorithm, breakpoint location, and relative chromosome segment sizes proved not to be independent predictors of the percentage of balanced embryos. The ratio of the relative sizes of the translocated segments of both translocation chromosomes can give some insight into the chance of transferable embryos: Very asymmetrical translocations have a higher risk of unbalanced products (p = 0.048). Counseling of the couples on the pros and cons of all their reproductive options remains very important. PMID:26237378

Can Characteristics of Reciprocal Translocations Predict the Chance of Transferable Embryos in PGD Cycles?

PubMed

Dul, Elsbeth; van Echten-Arends, Jannie; Groen, Henk; Kastrop, Peter; Wissen, Lucie Amory-van; Engelen, John; Land, Jolande; Coonen, Edith; van Ravenswaaij-Arts, Conny

2014-04-02

Translocation carriers have an increased risk of miscarriage or the birth of a child with congenital anomalies. Preimplantation genetic diagnosis (PGD) is performed in translocation carriers to select for balanced embryos and, thus, increase the chance of an ongoing pregnancy. However, a common experience is that reciprocal translocation carriers produce a high percentage of unbalanced embryos, which cannot be transferred. Therefore, the pregnancy rates in PGD in this patient group are low. In a cohort of 85 reciprocal translocation carriers undergoing PGD we have searched for cytogenetic characteristics of the translocations that can predict the percentage of balanced embryos. Using shape algorithms, the most likely segregation mode per translocation was determined. Shape algorithm, breakpoint location, and relative chromosome segment sizes proved not to be independent predictors of the percentage of balanced embryos. The ratio of the relative sizes of the translocated segments of both translocation chromosomes can give some insight into the chance of transferable embryos: Very asymmetrical translocations have a higher risk of unbalanced products (p = 0.048). Counseling of the couples on the pros and cons of all their reproductive options remains very important.

Asymmetric bagging and feature selection for activities prediction of drug molecules.

PubMed

Li, Guo-Zheng; Meng, Hao-Hua; Lu, Wen-Cong; Yang, Jack Y; Yang, Mary Qu

2008-05-28

Activities of drug molecules can be predicted by QSAR (quantitative structure activity relationship) models, which overcomes the disadvantages of high cost and long cycle by employing the traditional experimental method. With the fact that the number of drug molecules with positive activity is rather fewer than that of negatives, it is important to predict molecular activities considering such an unbalanced situation. Here, asymmetric bagging and feature selection are introduced into the problem and asymmetric bagging of support vector machines (asBagging) is proposed on predicting drug activities to treat the unbalanced problem. At the same time, the features extracted from the structures of drug molecules affect prediction accuracy of QSAR models. Therefore, a novel algorithm named PRIFEAB is proposed, which applies an embedded feature selection method to remove redundant and irrelevant features for asBagging. Numerical experimental results on a data set of molecular activities show that asBagging improve the AUC and sensitivity values of molecular activities and PRIFEAB with feature selection further helps to improve the prediction ability. Asymmetric bagging can help to improve prediction accuracy of activities of drug molecules, which can be furthermore improved by performing feature selection to select relevant features from the drug molecules data sets.

Energy Balanced Strategies for Maximizing the Lifetime of Sparsely Deployed Underwater Acoustic Sensor Networks

PubMed Central

Luo, Hanjiang; Guo, Zhongwen; Wu, Kaishun; Hong, Feng; Feng, Yuan

2009-01-01

Underwater acoustic sensor networks (UWA-SNs) are envisioned to perform monitoring tasks over the large portion of the world covered by oceans. Due to economics and the large area of the ocean, UWA-SNs are mainly sparsely deployed networks nowadays. The limited battery resources is a big challenge for the deployment of such long-term sensor networks. Unbalanced battery energy consumption will lead to early energy depletion of nodes, which partitions the whole networks and impairs the integrity of the monitoring datasets or even results in the collapse of the entire networks. On the contrary, balanced energy dissipation of nodes can prolong the lifetime of such networks. In this paper, we focus on the energy balance dissipation problem of two types of sparsely deployed UWA-SNs: underwater moored monitoring systems and sparsely deployed two-dimensional UWA-SNs. We first analyze the reasons of unbalanced energy consumption in such networks, then we propose two energy balanced strategies to maximize the lifetime of networks both in shallow and deep water. Finally, we evaluate our methods by simulations and the results show that the two strategies can achieve balanced energy consumption per node while at the same time prolong the networks lifetime. PMID:22399970

Evaluating the effectiveness of Washington state repeated job search services on the employment rate of prime-age female welfare recipients☆

PubMed Central

Hsiao, Cheng; Shen, Yan; Wang, Boqing; Weeks, Greg

2014-01-01

This paper uses an unbalanced panel dataset to evaluate how repeated job search services (JSS) and personal characteristics affect the employment rate of the prime-age female welfare recipients in the State of Washington. We propose a transition probability model to take into account issues of sample attrition, sample refreshment and duration dependence. We also generalize Honoré and Kyriazidou’s [Honoré, B.E., Kyriazidou, E., 2000. Panel data discrete choice models with lagged dependent variables. Econometrica 68 (4), 839–874] conditional maximum likelihood estimator to allow for the presence of individual-specific effects. A limited information test is suggested to test for selection issues in non-experimental data. The specification tests indicate that the (conditional on the set of the confounding variables considered) assumptions of no selection due to unobservables and/or no unobserved individual-specific effects are not violated. Our findings indicate that the first job search service does have positive and significant impacts on the employment rate. However, providing repeated JSS to the same client has no significant impact. Further, we find that there are significant experience-enhancing effects. These findings suggest that providing one job search services training to individuals may have a lasting impact on raising their employment rates. PMID:26052178

Evaluating the effectiveness of Washington state repeated job search services on the employment rate of prime-age female welfare recipients.

PubMed

Hsiao, Cheng; Shen, Yan; Wang, Boqing; Weeks, Greg

2008-07-01

This paper uses an unbalanced panel dataset to evaluate how repeated job search services (JSS) and personal characteristics affect the employment rate of the prime-age female welfare recipients in the State of Washington. We propose a transition probability model to take into account issues of sample attrition, sample refreshment and duration dependence. We also generalize Honoré and Kyriazidou's [Honoré, B.E., Kyriazidou, E., 2000. Panel data discrete choice models with lagged dependent variables. Econometrica 68 (4), 839-874] conditional maximum likelihood estimator to allow for the presence of individual-specific effects. A limited information test is suggested to test for selection issues in non-experimental data. The specification tests indicate that the (conditional on the set of the confounding variables considered) assumptions of no selection due to unobservables and/or no unobserved individual-specific effects are not violated. Our findings indicate that the first job search service does have positive and significant impacts on the employment rate. However, providing repeated JSS to the same client has no significant impact. Further, we find that there are significant experience-enhancing effects. These findings suggest that providing one job search services training to individuals may have a lasting impact on raising their employment rates.

The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility

PubMed Central

Fontana, Roberta; Della Torre, Sara

2016-01-01

In female mammals, mechanisms have been developed, throughout evolution, to integrate environmental, nutritional and hormonal cues in order to guarantee reproduction in favorable energetic conditions and to inhibit it in case of food scarcity. This metabolic strategy could be an advantage in nutritionally poor environments, but nowadays is affecting women’s health. The unlimited availability of nutrients, in association with reduced energy expenditure, leads to alterations in many metabolic pathways and to impairments in the finely tuned inter-relation between energy metabolism and reproduction, thereby affecting female fertility. Many energetic states could influence female reproductive health being under- and over-weight, obesity and strenuous physical activity are all conditions that alter the profiles of specific hormones, such as insulin and adipokines, thus impairing women fertility. Furthermore, specific classes of nutrients might affect female fertility by acting on particular signaling pathways. Dietary fatty acids, carbohydrates, proteins and food-associated components (such as endocrine disruptors) have per se physiological activities and their unbalanced intake, both in quantitative and qualitative terms, might impair metabolic homeostasis and fertility in premenopausal women. Even though we are far from identifying a “fertility diet”, lifestyle and dietary interventions might represent a promising and invaluable strategy to manage infertility in premenopausal women. PMID:26875986

Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids

PubMed Central

Cardoso, Henriqueta D.; Passos, Priscila P.; Lagranha, Claudia J.; Ferraz, Anete C.; Santos Júnior, Eraldo F.; Oliveira, Rafael S.; Oliveira, Pablo E. L.; Santos, Rita de C. F.; Santana, David F.; Borba, Juliana M. C.; Rocha-de-Melo, Ana P.; Guedes, Rubem C. A.; Navarro, Daniela M. A. F.; Santos, Geanne K. N.; Borner, Roseane; Picanço-Diniz, Cristovam W.; Beltrão, Eduardo I.; Silva, Janilson F.; Rodrigues, Marcelo C. A.; Andrade da Costa, Belmira L. S.

2012-01-01

Oxidative stress (OS) has been implicated in the etiology of certain neurodegenerative disorders. Some of these disorders have been associated with unbalanced levels of essential fatty acids (EFA). The response of certain brain regions to OS, however, is not uniform and a selective vulnerability or resilience can occur. In our previous study on rat brains, we observed that a two-generation EFA dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (SN) rostro-dorso-medial. To understand whether OS contributes to this effect, we assessed the status of lipid peroxidation (LP) and anti-oxidant markers in both SN and corpus striatum (CS) of rats submitted to this dietary treatment for one (F1) or two (F2) generations. Wistar rats were raised from conception on control or experimental diets containing adequate or reduced levels of linoleic and α-linolenic fatty acids, respectively. LP was measured using the thiobarbituric acid reaction method (TBARS) and the total superoxide dismutase (t-SOD) and catalase (CAT) enzymatic activities were assessed. The experimental diet significantly reduced the docosahexaenoic acid (DHA) levels of SN phospholipids in the F1 (~28%) and F2 (~50%) groups. In F1 adult animals of the experimental group there was no LP in both SN and CS. Consistently, there was a significant increase in the t-SOD activity (p < 0.01) in both regions. In EF2 young animals, degeneration in dopaminergic and non-dopaminergic neurons and a significant increase in LP (p < 0.01) and decrease in the CAT activity (p < 0.001) were detected in the SN, while no inter-group difference was found for these parameters in the CS. Conversely, a significant increase in t-SOD activity (p < 0.05) was detected in the CS of the experimental group compared to the control. The results show that unbalanced EFA dietary levels reduce the redox balance in the SN and reveal mechanisms of resilience in the CS under this stressful condition. PMID:22969716

Distribution of active faulting along orogenic wedges: Minimum-work models and natural analogue

NASA Astrophysics Data System (ADS)

Yagupsky, Daniel L.; Brooks, Benjamin A.; Whipple, Kelin X.; Duncan, Christopher C.; Bevis, Michael

2014-09-01

Numerical 2-D models based on the principle of minimum work were used to examine the space-time distribution of active faulting during the evolution of orogenic wedges. A series of models focused on thin-skinned thrusting illustrates the effects of arid conditions (no erosion), unsteady state conditions (accretionary influx greater than erosional efflux) and steady state conditions (accretionary influx balances erosional efflux), on the distribution of fault activity. For arid settings, a general forward accretion sequence prevails, although a significant amount of internal deformation is registered: the resulting fault pattern is a rather uniform spread along the profile. Under fixed erosional efficiency settings, the frontal advance of the wedge-front is inhibited, reaching a steady state after a given forward propagation. Then, the applied shortening is consumed by surface ruptures over a narrow frontal zone. Under a temporal increase in erosional efficiency (i.e., transient non-steady state mass balance conditions), a narrowing of the synthetic wedge results; a rather diffuse fault activity distribution is observed during the deformation front retreat. Once steady balanced conditions are reached, a single long-lived deformation front prevails. Fault activity distribution produced during the deformation front retreat of the latter scenario, compares well with the structural evolution and hinterlandward deformation migration identified in southern Bolivian Subandes (SSA) from late Miocene to present. This analogy supports the notion that the SSA is not in steady state, but is rather responding to an erosional efficiency increase since late Miocene. The results shed light on the impact of different mass balance conditions on the vastly different kinematics found in mountain ranges, suggesting that those affected by growing erosion under a transient unbalanced mass flux condition tend to distribute deformation along both frontal and internal faults, while others under balanced conditions would display focused deformation on a limited number of steady structures.

Gender Equity in High School World History Curriculum: Support for a Balanced Perspective

ERIC Educational Resources Information Center

Brackett, Kirianne

2008-01-01

We are providing our secondary students with an unbalanced, inaccurate view of world history, this can lead to greater social injustice. The purpose of this paper is two-fold: (1) examine the reasons for and issues with providing a gender balanced view of history in order to lead to a more well rounded illustration of history; and (2) demonstrate…

Infantile spasms with periventricular nodular heterotopia, unbalanced chromosomal translocation 3p26.2 -10p15.1 and 6q22.31 duplication.

PubMed

Jones, Kevin; Weiss, Shelly K; Minassian, Berge

2016-07-01

Patients presenting with infantile spasms, dysmorphic features, and periventricular nodular heterotopia may benefit from genetic copy number variation microarray, or whole-exome sequencing to identify candidate genes. This will allow personalized diagnosis and prognostication and the eventual understanding of single and combined gene functions in brain health and disease.

University Language Policies and Language Choice among Ph.D. Graduates in Estonia: The (Unbalanced) Interplay between English and Estonian

ERIC Educational Resources Information Center

Soler-Carbonell, Josep

2014-01-01

The role of English as a global language and its consequences for the internationalization of higher education are matters that have increasingly drawn the attention of researchers from different fields of language and communication. In this paper, an overview of the situation in Estonia is presented. The Estonian context has not previously been…

Compact transmission system using single-sideband modulation of light for quantum cryptography.

PubMed

Duraffourg, L; Merolla, J M; Goedgebuer, J P; Mazurenko, Y; Rhodes, W T

2001-09-15

We report a new transmission that can be used for quantum key distribution. The system uses single-sideband-modulated light in an implementation of the BB84 quantum cryptography protocol. The system is formed by two integrated unbalanced Mach-Zehnder interferometers and is based on interference between phase-modulated sidebands in the spectral domain. Experiments show that high interference visibility can be obtained.

The Expected Sample Variance of Uncorrelated Random Variables with a Common Mean and Some Applications in Unbalanced Random Effects Models

ERIC Educational Resources Information Center

Vardeman, Stephen B.; Wendelberger, Joanne R.

2005-01-01

There is a little-known but very simple generalization of the standard result that for uncorrelated random variables with common mean [mu] and variance [sigma][superscript 2], the expected value of the sample variance is [sigma][superscript 2]. The generalization justifies the use of the usual standard error of the sample mean in possibly…

Neither Good nor Useful: Looking Ad Vivum in Children's Assessments of Fat and Healthy Bodies

ERIC Educational Resources Information Center

Harwood, Valerie

2012-01-01

Fat bodies are not, fait accompli, bad. Yet in our international research, we found overwhelmingly that fat functioned as a marker to indicate health or lack of health. A body with fat was simply and conclusively unhealthy. This article reports on how this unbalanced view of fat was tied to assessments of healthy bodies that were achieved by…

In Search of a Cure for Proteostasis-Addicted Cancer: A AAA Target Revealed.

PubMed

Xia, Di; Ye, Yihong

2015-11-09

Tumorigenesis is often associated with an unbalanced protein homeostasis (proteostasis) network, which sensitizes cancer cells to drugs targeting protein quality control (PQC) regulators. In this issue of Cancer Cell, Anderson and colleagues investigated the anti-cancer activity of a new class of inhibitor against a multi-functional ATPase essential for proteostasis maintenance. Copyright © 2015 Elsevier Inc. All rights reserved.

Exploring a New Technique for Comparing Bilinguals' L1 and L2 Reading Speed

ERIC Educational Resources Information Center

Gauvin, Hanna S.; Hulstijn, Jan H.

2010-01-01

Is it possible to tell whether bilinguals are able to read simple text in their two languages equally fluently? Is it thus possible to distinguish balanced bilinguals from unbalanced bilinguals with respect to reading fluency in their first language (L1) and second language (L2)? In this study, we avoided making direct comparisons between L1 and…

The microcomputer scientific software series 3: general linear model--analysis of variance.

Treesearch

Harold M. Rauscher

1985-01-01

A BASIC language set of programs, designed for use on microcomputers, is presented. This set of programs will perform the analysis of variance for any statistical model describing either balanced or unbalanced designs. The program computes and displays the degrees of freedom, Type I sum of squares, and the mean square for the overall model, the error, and each factor...

Plant Disease Severity Assessment-How Rater Bias, Assessment Method, and Experimental Design Affect Hypothesis Testing and Resource Use Efficiency.

PubMed

Chiang, Kuo-Szu; Bock, Clive H; Lee, I-Hsuan; El Jarroudi, Moussa; Delfosse, Philippe

2016-12-01

The effect of rater bias and assessment method on hypothesis testing was studied for representative experimental designs for plant disease assessment using balanced and unbalanced data sets. Data sets with the same number of replicate estimates for each of two treatments are termed "balanced" and those with unequal numbers of replicate estimates are termed "unbalanced". The three assessment methods considered were nearest percent estimates (NPEs), an amended 10% incremental scale, and the Horsfall-Barratt (H-B) scale. Estimates of severity of Septoria leaf blotch on leaves of winter wheat were used to develop distributions for a simulation model. The experimental designs are presented here in the context of simulation experiments which consider the optimal design for the number of specimens (individual units sampled) and the number of replicate estimates per specimen for a fixed total number of observations (total sample size for the treatments being compared). The criterion used to gauge each method was the power of the hypothesis test. As expected, at a given fixed number of observations, the balanced experimental designs invariably resulted in a higher power compared with the unbalanced designs at different disease severity means, mean differences, and variances. Based on these results, with unbiased estimates using NPE, the recommended number of replicate estimates taken per specimen is 2 (from a sample of specimens of at least 30), because this conserves resources. Furthermore, for biased estimates, an apparent difference in the power of the hypothesis test was observed between assessment methods and between experimental designs. Results indicated that, regardless of experimental design or rater bias, an amended 10% incremental scale has slightly less power compared with NPEs, and that the H-B scale is more likely than the others to cause a type II error. These results suggest that choice of assessment method, optimizing sample number and number of replicate estimates, and using a balanced experimental design are important criteria to consider to maximize the power of hypothesis tests for comparing treatments using disease severity estimates.

Determinants of health-related lifestyles among university students.

PubMed

Aceijas, Carmen; Waldhäusl, Sabrina; Lambert, Nicky; Cassar, Simon; Bello-Corassa, Rafael

2017-07-01

The aim of this study was to investigate students' health-related lifestyles and to identify barriers and social determinants of healthier lifestyles. An online survey, two focus groups and three in-depth interviews across 2014/2015. A stratified by school size and random sample ( n = 468) of university students answered a 67-item questionnaire comprising six scales: Rapid Assessment of Physical Activity, Rapid Eating and Activity Assessment for Patients-Short Version, CAGE, Fagerström Test for Nicotine Dependence, Warwick-Edinburgh Mental Wellbeing Scale short version, and ad hoc scale for drug use/misuse. Stratified by gender, χ 2 tests were run to test associations/estimate risks and three multivariate Logistic Regression models were adjusted. A thematic approach guided the analysis of qualitative data. A total of 60% of the respondents were insufficiently physically active, 47% had an unbalanced diet and 30% had low mental wellbeing. Alcohol drinkers versus abstinent were almost equally distributed. A total of 42% of alcohol drinkers reported getting drunk at least once a month. Smokers accounted for 16% of the respondents. Identified risk factors for suboptimal physical activity were as follows: being a woman, not using the university gym and smoking. Risk factors for unbalanced diet were low mental wellbeing and drug use. Poor mental wellbeing was predicted by unbalanced diet, not feeling like shopping and cooking frequently, and a lack of help-seeking behaviour in cases of distress. Qualitative analysis revealed seven thematic categories: transition to new life, university environment and systems, finances, academic pressure, health promotion on campus and recommendations. This study provides robust evidence that the health-related lifestyles of the student population are worrying and suggests that the trend in chronic diseases associated with unhealthy lifestyles sustained over years might be unlikely to change in future generations. University students' health-related lifestyle is a concern. Nine out of the identified 10 predictors of problematic physical activity, nutrition and mental wellbeing, were environmental/societal or institutional barriers. Universities must expand corporate responsibilities to include the promotion of health as part of their core values.

Meiotic and pedigree segregation analyses in carriers of t(4;8)(p16;p23.1) differing in localization of breakpoint positions at 4p subband 4p16.3 and 4p16.1.

PubMed

Midro, Alina T; Zollino, Marcella; Wiland, Ewa; Panasiuk, Barbara; Iwanowski, Piotr S; Murdolo, Marina; Śmigiel, Robert; Sąsiadek, Maria; Pilch, Jacek; Kurpisz, Maciej

2016-02-01

The purpose of this study was to compare meiotic segregation in sperm cells from two carriers with t(4;8)(p16;p23.1) reciprocal chromosome translocations (RCTs), differing in localization of the breakpoint positions at the 4p subband-namely, 4p16.3 (carrier 1) and 4p16.1 (carrier 2)-and to compare data of the pedigree analyses performed by direct method. Three-color fluorescent in situ hybridization (FISH) on sperm cells and FISH mapping for the evaluation of the breakpoint positions, data from pedigrees, and direct segregation analysis of the pedigrees were performed. Similar proportions of normal/balanced and unbalanced sperm cells were found in both carriers. The most common was an alternate type of segregation (about 52 % and about 48 %, respectively). Unbalanced adjacent I and adjacent II karyotypes were found in similar proportions about 15 %. The direct segregation analysis (following Stengel-Rutkowski) of the pedigree of carriers of t(4;8)(p16.1;p23.1) was performed and results were compared with the data of the pedigree segregation analysis obtained earlier through the indirect method. The probability of live-born progeny with unbalanced karyotype for carriers of t(4;8)(p16.1;p23.1) was moderately high at 18.8 %-comparable to the value obtained using the indirect method for the same carriership, which was 12 %. This was, however, markedly lower than the value of 41.2 % obtained through the pedigree segregation indirect analysis estimated for carriers of t(4;8)(p16.3;p23.1), perhaps due to the unique composition of genes present within the 4p16.1-4p 16.3 region. Revealed differences in pedigree segregation analysis did not correspond to the very similar profile of meiotic segregation patterns presented by carrier 1 and carrier 2. Most probably, such discordances may be due to differences in embryo survival rates arising from different genetic backgrounds.

Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases.

PubMed

Hodge, Jennelle C; Pearce, Kathryn E; Wang, Xiaoke; Wiktor, Anne E; Oliveira, Andre M; Greipp, Patricia T

2014-01-01

Renal cell carcinoma with TFE3 rearrangement at Xp11.2 is a distinct subtype manifesting an indolent clinical course in children, with recent reports suggesting a more aggressive entity in adults. This subtype is morphologically heterogeneous and can be misclassified as clear cell or papillary renal cell carcinoma. TFE3 is also rearranged in alveolar soft part sarcoma. To aid in diagnosis, a break-apart strategy fluorescence in situ hybridization (FISH) probe set specific for TFE3 rearrangement and a reflex dual-color, single-fusion strategy probe set involving the most common TFE3 partner gene, ASPSCR1, were validated on formalin-fixed, paraffin-embedded tissues from nine alveolar soft part sarcoma, two suspected Xp11.2 renal cell carcinoma, and nine tumors in the differential diagnosis. The impact of tissue cut artifact was reduced through inclusion of a chromosome X centromere control probe. Analysis of the UOK-109 renal carcinoma cell line confirmed the break-apart TFE3 probe set can distinguish the subtle TFE3/NONO fusion-associated inversion of chromosome X. Subsequent extensive clinical experience was gained through analysis of 75 cases with an indication of Xp11.2 renal cell carcinoma (n=54), alveolar soft part sarcoma (n=13), perivascular epithelioid cell neoplasms (n=2), chordoma (n=1), or unspecified (n=5). We observed balanced and unbalanced chromosome X;17 translocations in both Xp11.2 renal cell carcinoma and alveolar soft part sarcoma, supporting a preference but not a necessity for the translocation to be balanced in the carcinoma and unbalanced in the sarcoma. We further demonstrate the unbalanced separation is atypical, with TFE3/ASPSCR1 fusion and loss of the derivative X chromosome but also an unanticipated normal X chromosome gain in both males and females. Other diverse sex chromosome copy number combinations were observed. Our TFE3 FISH assay is a useful adjunct to morphologic analysis of such challenging cases and will be applicable to assess the growing spectrum of TFE3-rearranged tumors.

Effects of news frames on perceived risk, emotions, and learning.

PubMed

Otieno, Christine; Spada, Hans; Renkl, Alexander

2013-01-01

The media play a key role in forming opinions by influencing people´s understanding and perception of a topic. People gather information about topics of interest from the internet and print media, which employ various news frames to attract attention. One example of a common news frame is the human-interest frame, which emotionalizes and dramatizes information and often accentuates individual affectedness. Our study investigated effects of human-interest frames compared to a neutral-text condition with respect to perceived risk, emotions, and knowledge acquisition, and tested whether these effects can be "generalized" to common variants of the human-interest frame. Ninety-one participants read either one variant of the human-interest frame or a neutrally formulated version of a newspaper article describing the effects of invasive species in general and the Asian ladybug (an invasive species) in particular. The framing was achieved by varying the opening and concluding paragraphs (about invasive species), as well as the headline. The core text (about the Asian ladybug) was the same across all conditions. All outcome variables on framing effects referred to this common core text. We found that all versions of the human-interest frame increased perceived risk and the strength of negative emotions compared to the neutral text. Furthermore, participants in the human-interest frame condition displayed better (quantitative) learning outcomes but also biased knowledge, highlighting a potential dilemma: Human-interest frames may increase learning, but they also lead to a rather unbalanced view of the given topic on a "deeper level".

Narrow-linewidth tunable laser working at 633 nm suitable for industrial interferometry

NASA Astrophysics Data System (ADS)

Minh, Tuan Pham; Hucl, Václav; Čížek, Martin; Mikel, Břetislav; Hrabina, Jan; Řeřucha, Šimon; Číp, Ondřej; Lazar, Josef

2015-05-01

Semiconductor lasers found a foothold in many fields of human activities, mainly thanks to its small size, low cost and high energy efficiency. Recent methods for accurate distance measurement in industrial practice use principles of laser interferometry, which are based on lasers operating in the visible spectrum. When the laser beam is visible the alignment of the industrial interferometer makes the measuring process easier. Traditional lasers for these purposes for many decades - HeNe gas laser - have superb coherence properties but small tunable range. On the other hand laser diodes are very useful lasers but only if the active layer of the semiconductor equips with a passive selective element that will increase the quality of their own resonator and also prevents the structure of its higher longitudinal modes. The main aim of the work is a design of the laser source based on a new commercial available laser diode with Distributed Bragg Reflector structure, butterfly package and fibre coupled output. The ultra-low noise injection current source, stable temperature controller and supply electronic equipment were developed with us and experimentally tested with this laser for the best performances required of the industrial interferometry field. The work also performs a setup for frequency noise properties investigation with an unbalanced fibre based Mach-Zehnder interferometer and 10 m long fibre spool inserted in the reference arm. The work presents the way to developing the narrow-linewidth operation the DBR laser with the wide tunable range up to more than 1 nm of the operation wavelength at the same time. Both capabilities predetermine this complex setup for the industrial interferometry application as they are the long distance surveying or absolute scale interferometry.

Paradigms for Tropical-Cyclone Intensification

DTIC Science & Technology

2011-01-01

Hurricane Opal (1995) using the Geo- physical Fluid Dynamics Laboratory hurricane prediction model, Möller and Shapiro (2002) found unbalanced flow...al. (2008) calculations on an f -plane, described in section 6.1. A specific aim was to deter- mine the separate contributions of diabatic heating and... Opal as diagnosed from a GFDL model forecast. Mon. Wea. Rev., 130, 1866-1881. Marks FD Shay LK. 1998: Landfalling tropical cyclones: Forecast

Evaluating effectiveness of down-sampling for stratified designs and unbalanced prevalence in Random Forest models of tree species distributions in Nevada

Treesearch

Elizabeth A. Freeman; Gretchen G. Moisen; Tracy S. Frescino

2012-01-01

Random Forests is frequently used to model species distributions over large geographic areas. Complications arise when data used to train the models have been collected in stratified designs that involve different sampling intensity per stratum. The modeling process is further complicated if some of the target species are relatively rare on the landscape leading to an...

Time-division multiplexing of polarization-insensitive fiber-optic Michelson interferometric sensors

NASA Astrophysics Data System (ADS)

Huang, S. C.; Lin, W. W.; Chen, M. H.

1995-06-01

A system of time-division multiplexing of polarization-insensitive fiber-optic Michelson interferometric sensors that uses Faraday rotator mirror elements is demonstrated. This system is constructed with conventional low-birefringence single-mode fiber and is able to solve the polarization-fading problem by a combination of Faraday rotator mirrors with unbalanced Michelson interferometers. The system is lead-fiber insensitive and has potentials for practical field applications.

Reflection on Balanced Allocation of Fundamental Education Teachers in Poverty-Stricken Areas of Ethnic Minorities: Example of a Survey in the Tibetan Autonomous County of Tianzhu in Gansu Province

ERIC Educational Resources Information Center

Yang, Jun

2006-01-01

Balanced allocation of fundamental education teachers is one of the most important ways to achieve the highest quality of compulsory education. It also guarantees an accelerated achievement of a balanced development of fundamental education. In poverty-stricken areas of ethnic minorities, unbalanced teacher allocation is a major factor that…

A Survey of the Problem of Unbalanced High School Educational Resource Allocation within the County Region in Gansu Province--Using Seven High Schools in Three Counties as an Example

ERIC Educational Resources Information Center

Kai, Liu; Gaofu, Du

2015-01-01

The imbalance in allocating high school educational resources within the county region has expanded the imbalances in local high school educational development. This has caused "diseconomies of scale" in high schools, aggravated the "expansion impulse" in building model high schools, limited the growth of effective demand by…

Characterization of Stationary Distributions of Reflected Diffusions

DTIC Science & Technology

2014-01-01

Reiman , M. I. (2003). Fluid and heavy traffic limits for a generalized processor sharing model. Ann. Appl. Probab., 13, 100-139. [37] Ramanan, K. and... Reiman , M. I. (2008). The heavy traffic limit of an unbalanced generalized processor sharing model. Ann. Appl. Probab., 18, 22-58. [38] Reed, J. and...Control and Computing. [39] Reiman , M. I. and Williams, R. J. (1988). A boundary property of semimartingale reflecting Brownian motions. Probab. Theor

On the high Mach number shock structure singularity caused by overreach of Maxwellian molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myong, R. S., E-mail: myong@gnu.ac.kr

2014-05-15

The high Mach number shock structure singularity arising in moment equations of the Boltzmann equation was investigated. The source of the singularity is shown to be the unbalanced treatment between two high order kinematic and dissipation terms caused by the overreach of Maxwellian molecule assumption. In compressive gaseous flow, the high order stress-strain coupling term of quadratic nature will grow far faster than the strain term, resulting in an imbalance with the linear dissipation term and eventually a blow-up singularity in high thermal nonequilibrium. On the other hand, the singularity arising from unbalanced treatment does not occur in the casemore » of velocity shear and expansion flows, since the high order effects are cancelled under the constraint of the free-molecular asymptotic behavior. As an alternative method to achieve the balanced treatment, Eu's generalized hydrodynamics, consistent with the second law of thermodynamics, was revisited. After introducing the canonical distribution function in exponential form and applying the cumulant expansion to the explicit calculation of the dissipation term, a natural platform suitable for the balanced treatment was derived. The resulting constitutive equation with the nonlinear factor was then shown to be well-posed for all regimes, effectively removing the high Mach number shock structure singularity.« less

Nonlinear dynamic behaviors of permanent magnet synchronous motors in electric vehicles caused by unbalanced magnetic pull

NASA Astrophysics Data System (ADS)

Xiang, Changle; Liu, Feng; Liu, Hui; Han, Lijin; Zhang, Xun

2016-06-01

Unbalanced magnetic pull (UMP) plays a key role in nonlinear dynamic behaviors of permanent magnet synchronous motors (PMSM) in electric vehicles. Based on Jeffcott rotor model, the stiffness characteristics of the rotor system of the PMSM are analyzed and the nonlinear dynamic behaviors influenced by UMP are investigated. In free vibration study, eigenvalue-based stability analysis for multiple equilibrium points is performed which offers an insight in system stiffness. Amplitude modulation effects are discovered of which the mechanism is explained and the period of modulating signal is carried out by phase analysis and averaging method. The analysis indicates that the effects are caused by the interaction of the initial phases of forward and backward whirling motions. In forced vibration study, considering dynamic eccentricity, frequency characteristics revealing softening type are obtained by harmonic balance method, and the stability of periodic solution is investigated by Routh-Hurwitz criterion. The frequency characteristics analysis indicates that the response amplitude is limited in the range between the amplitudes of the two kinds of equilibrium points. In the vicinity of the continuum of equilibrium points, the system hardly provides resistance to bending, and hence external disturbances easily cause loss of stability. It is useful for the design of the PMSM with high stability and low vibration and acoustic noise.

The Effect of Supply Disruptions on Customer Service Levels: a Case for Delivering Fertilizer Products using Maritime Transportation

NASA Astrophysics Data System (ADS)

Siswanto, N.; Kurniawati, U.; Wiratno, S. E.; Rusdiansyah, A.

2018-04-01

Delivering a product to customers can have a series of activities. It starts with the production of the product and then transporting it to the customers. However, uncontrollable and undesirable chance of disruption can occur during the delivery either at the production facility/supply side or in the process of transporting the product. Many researches has been conducting in the process of delivering the product. However not many considers these disruptions, although the disruptions has negative impacts on company such as reduce the profit, produce unbalanced inventory, and affect its reputation. This research will focus on the effect of supply disruption on customer service levels in the maritime transportation problem in order to maintain inventory level both in the supply and destination warehouses during predetermined planning horizon. The system considered consists of one loading port and two discharge ports for distributing one product. By using discrete event simulation, the result showed that supply disruption affects unbalanced inventory in the destination warehouses so that it will also influence company’s service level. The results show that there is a significant decreasing both in delivery service level, about 14%, and production service level, about 15% when the disruption occurs. A scenario to increase production rate is simulated to improved the service level.