A generalized reconstruction framework for unconventional PET systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mathews, Aswin John, E-mail: amathews@wustl.edu; Li, Ke; O’Sullivan, Joseph A.
2015-08-15
Purpose: Quantitative estimation of the radionuclide activity concentration in positron emission tomography (PET) requires precise modeling of PET physics. The authors are focused on designing unconventional PET geometries for specific applications. This work reports the creation of a generalized reconstruction framework, capable of reconstructing tomographic PET data for systems that use right cuboidal detector elements positioned at arbitrary geometry using a regular Cartesian grid of image voxels. Methods: The authors report on a variety of design choices and optimization for the creation of the generalized framework. The image reconstruction algorithm is maximum likelihood-expectation–maximization. System geometry can be specified using amore » simple script. Given the geometry, a symmetry seeking algorithm finds existing symmetry in the geometry with respect to the image grid to improve the memory usage/speed. Normalization is approached from a geometry independent perspective. The system matrix is computed using the Siddon’s algorithm and subcrystal approach. The program is parallelized through open multiprocessing and message passing interface libraries. A wide variety of systems can be modeled using the framework. This is made possible by modeling the underlying physics and data correction, while generalizing the geometry dependent features. Results: Application of the framework for three novel PET systems, each designed for a specific application, is presented to demonstrate the robustness of the framework in modeling PET systems of unconventional geometry. Three PET systems of unconventional geometry are studied. (1) Virtual-pinhole half-ring insert integrated into Biograph-40: although the insert device improves image quality over conventional whole-body scanner, the image quality varies depending on the position of the insert and the object. (2) Virtual-pinhole flat-panel insert integrated into Biograph-40: preliminary results from an investigation into a modular flat-panel insert are presented. (3) Plant PET system: a reconfigurable PET system for imaging plants, with resolution of greater than 3.3 mm, is shown. Using the automated symmetry seeking algorithm, the authors achieved a compression ratio of the storage and memory requirement by a factor of approximately 50 for the half-ring and flat-panel systems. For plant PET system, the compression ratio is approximately five. The ratio depends on the level of symmetry that exists in different geometries. Conclusions: This work brings the field closer to arbitrary geometry reconstruction. A generalized reconstruction framework can be used to validate multiple hypotheses and the effort required to investigate each system is reduced. Memory usage/speed can be improved with certain optimizations.« less
A generalized reconstruction framework for unconventional PET systems.
Mathews, Aswin John; Li, Ke; Komarov, Sergey; Wang, Qiang; Ravindranath, Bosky; O'Sullivan, Joseph A; Tai, Yuan-Chuan
2015-08-01
Quantitative estimation of the radionuclide activity concentration in positron emission tomography (PET) requires precise modeling of PET physics. The authors are focused on designing unconventional PET geometries for specific applications. This work reports the creation of a generalized reconstruction framework, capable of reconstructing tomographic PET data for systems that use right cuboidal detector elements positioned at arbitrary geometry using a regular Cartesian grid of image voxels. The authors report on a variety of design choices and optimization for the creation of the generalized framework. The image reconstruction algorithm is maximum likelihood-expectation-maximization. System geometry can be specified using a simple script. Given the geometry, a symmetry seeking algorithm finds existing symmetry in the geometry with respect to the image grid to improve the memory usage/speed. Normalization is approached from a geometry independent perspective. The system matrix is computed using the Siddon's algorithm and subcrystal approach. The program is parallelized through open multiprocessing and message passing interface libraries. A wide variety of systems can be modeled using the framework. This is made possible by modeling the underlying physics and data correction, while generalizing the geometry dependent features. Application of the framework for three novel PET systems, each designed for a specific application, is presented to demonstrate the robustness of the framework in modeling PET systems of unconventional geometry. Three PET systems of unconventional geometry are studied. (1) Virtual-pinhole half-ring insert integrated into Biograph-40: although the insert device improves image quality over conventional whole-body scanner, the image quality varies depending on the position of the insert and the object. (2) Virtual-pinhole flat-panel insert integrated into Biograph-40: preliminary results from an investigation into a modular flat-panel insert are presented. (3) Plant PET system: a reconfigurable PET system for imaging plants, with resolution of greater than 3.3 mm, is shown. Using the automated symmetry seeking algorithm, the authors achieved a compression ratio of the storage and memory requirement by a factor of approximately 50 for the half-ring and flat-panel systems. For plant PET system, the compression ratio is approximately five. The ratio depends on the level of symmetry that exists in different geometries. This work brings the field closer to arbitrary geometry reconstruction. A generalized reconstruction framework can be used to validate multiple hypotheses and the effort required to investigate each system is reduced. Memory usage/speed can be improved with certain optimizations.
A generalized reconstruction framework for unconventional PET systems
Mathews, Aswin John; Li, Ke; Komarov, Sergey; Wang, Qiang; Ravindranath, Bosky; O’Sullivan, Joseph A.; Tai, Yuan-Chuan
2015-01-01
Purpose: Quantitative estimation of the radionuclide activity concentration in positron emission tomography (PET) requires precise modeling of PET physics. The authors are focused on designing unconventional PET geometries for specific applications. This work reports the creation of a generalized reconstruction framework, capable of reconstructing tomographic PET data for systems that use right cuboidal detector elements positioned at arbitrary geometry using a regular Cartesian grid of image voxels. Methods: The authors report on a variety of design choices and optimization for the creation of the generalized framework. The image reconstruction algorithm is maximum likelihood-expectation–maximization. System geometry can be specified using a simple script. Given the geometry, a symmetry seeking algorithm finds existing symmetry in the geometry with respect to the image grid to improve the memory usage/speed. Normalization is approached from a geometry independent perspective. The system matrix is computed using the Siddon’s algorithm and subcrystal approach. The program is parallelized through open multiprocessing and message passing interface libraries. A wide variety of systems can be modeled using the framework. This is made possible by modeling the underlying physics and data correction, while generalizing the geometry dependent features. Results: Application of the framework for three novel PET systems, each designed for a specific application, is presented to demonstrate the robustness of the framework in modeling PET systems of unconventional geometry. Three PET systems of unconventional geometry are studied. (1) Virtual-pinhole half-ring insert integrated into Biograph-40: although the insert device improves image quality over conventional whole-body scanner, the image quality varies depending on the position of the insert and the object. (2) Virtual-pinhole flat-panel insert integrated into Biograph-40: preliminary results from an investigation into a modular flat-panel insert are presented. (3) Plant PET system: a reconfigurable PET system for imaging plants, with resolution of greater than 3.3 mm, is shown. Using the automated symmetry seeking algorithm, the authors achieved a compression ratio of the storage and memory requirement by a factor of approximately 50 for the half-ring and flat-panel systems. For plant PET system, the compression ratio is approximately five. The ratio depends on the level of symmetry that exists in different geometries. Conclusions: This work brings the field closer to arbitrary geometry reconstruction. A generalized reconstruction framework can be used to validate multiple hypotheses and the effort required to investigate each system is reduced. Memory usage/speed can be improved with certain optimizations. PMID:26233187
Open-field mouse brain PET: design optimisation and detector characterisation.
Kyme, Andre Z; Judenhofer, Martin S; Gong, Kuang; Bec, Julien; Selfridge, Aaron; Du, Junwei; Qi, Jinyi; Cherry, Simon R; Meikle, Steven R
2017-07-13
'Open-field' PET, in which an animal is free to move within an enclosed space during imaging, is a very promising advance for neuroscientific research. It provides a key advantage over conventional imaging under anesthesia by enabling functional changes in the brain to be correlated with an animal's behavioural response to environmental or pharmacologic stimuli. Previously we have demonstrated the feasibility of open-field imaging of rats using motion compensation techniques applied to a commercially available PET scanner. However, this approach of 'retro-fitting' motion compensation techniques to an existing system is limited by the inherent geometric and performance constraints of the system. The goal of this project is to develop a purpose-built PET scanner with geometry, motion tracking and imaging performance tailored and optimised for open-field imaging of the mouse brain. The design concept is a rail-based sliding tomograph which moves according to the animal's motion. Our specific aim in this work was to evaluate candidate scanner designs and characterise the performance of a depth-of-interaction detector module for the open-field system. We performed Monte Carlo simulations to estimate and compare the sensitivity and spatial resolution performance of four scanner geometries: a ring, parallel plate, and two box variants. Each system was based on a detector block consisting of a 23 × 23 array of 0.785 × 0.785 × 20 mm 3 LSO crystals (overall dim. 19.6 × 19.6 × 20 mm). We found that a DoI resolution capability of 3 mm was necessary to achieve approximately uniform sub-millimetre spatial resolution throughout the FoV for all scanners except the parallel-plate geometry. With this DoI performance, the sensitivity advantage afforded by the box geometry with overlapping panels (16% peak absolute sensitivity, a 36% improvement over the ring design) suggests this unconventional design is best suited for imaging the mouse brain. We also built and characterised the block detector modelled in the simulations, including a dual-ended readout based on 6 × 6 arrays of through-silicon-via silicon photomultipliers (active area 84%) for DoI estimation. Identification of individual crystals in the flood map was excellent, energy resolution varied from 12.4% ± 0.6% near the centre to 24.4% ± 3.4% at the ends of the crystal, and the average DoI resolution was 2.8 mm ± 0.35 mm near the central depth (10 mm) and 3.5 mm ± 1.0 mm near the ends. Timing resolution was 1.4 ± 0.14 ns. Therefore, the DoI detector module meets the target specifications for the application and will be used as the basis for a prototype open-field mouse PET scanner.
Open-field mouse brain PET: design optimisation and detector characterisation
NASA Astrophysics Data System (ADS)
Kyme, Andre Z.; Judenhofer, Martin S.; Gong, Kuang; Bec, Julien; Selfridge, Aaron; Du, Junwei; Qi, Jinyi; Cherry, Simon R.; Meikle, Steven R.
2017-08-01
‘Open-field’ PET, in which an animal is free to move within an enclosed space during imaging, is a very promising advance for neuroscientific research. It provides a key advantage over conventional imaging under anesthesia by enabling functional changes in the brain to be correlated with an animal’s behavioural response to environmental or pharmacologic stimuli. Previously we have demonstrated the feasibility of open-field imaging of rats using motion compensation techniques applied to a commercially available PET scanner. However, this approach of ‘retro-fitting’ motion compensation techniques to an existing system is limited by the inherent geometric and performance constraints of the system. The goal of this project is to develop a purpose-built PET scanner with geometry, motion tracking and imaging performance tailored and optimised for open-field imaging of the mouse brain. The design concept is a rail-based sliding tomograph which moves according to the animal’s motion. Our specific aim in this work was to evaluate candidate scanner designs and characterise the performance of a depth-of-interaction detector module for the open-field system. We performed Monte Carlo simulations to estimate and compare the sensitivity and spatial resolution performance of four scanner geometries: a ring, parallel plate, and two box variants. Each system was based on a detector block consisting of a 23 × 23 array of 0.785 × 0.785 × 20 mm3 LSO crystals (overall dim. 19.6 × 19.6 × 20 mm). We found that a DoI resolution capability of 3 mm was necessary to achieve approximately uniform sub-millimetre spatial resolution throughout the FoV for all scanners except the parallel-plate geometry. With this DoI performance, the sensitivity advantage afforded by the box geometry with overlapping panels (16% peak absolute sensitivity, a 36% improvement over the ring design) suggests this unconventional design is best suited for imaging the mouse brain. We also built and characterised the block detector modelled in the simulations, including a dual-ended readout based on 6 × 6 arrays of through-silicon-via silicon photomultipliers (active area 84%) for DoI estimation. Identification of individual crystals in the flood map was excellent, energy resolution varied from 12.4% ± 0.6% near the centre to 24.4% ± 3.4% at the ends of the crystal, and the average DoI resolution was 2.8 mm ± 0.35 mm near the central depth (10 mm) and 3.5 mm ± 1.0 mm near the ends. Timing resolution was 1.4 ± 0.14 ns. Therefore, the DoI detector module meets the target specifications for the application and will be used as the basis for a prototype open-field mouse PET scanner.
Efficient system modeling for a small animal PET scanner with tapered DOI detectors.
Zhang, Mengxi; Zhou, Jian; Yang, Yongfeng; Rodríguez-Villafuerte, Mercedes; Qi, Jinyi
2016-01-21
A prototype small animal positron emission tomography (PET) scanner for mouse brain imaging has been developed at UC Davis. The new scanner uses tapered detector arrays with depth of interaction (DOI) measurement. In this paper, we present an efficient system model for the tapered PET scanner using matrix factorization and a virtual scanner geometry. The factored system matrix mainly consists of two components: a sinogram blurring matrix and a geometrical matrix. The geometric matrix is based on a virtual scanner geometry. The sinogram blurring matrix is estimated by matrix factorization. We investigate the performance of different virtual scanner geometries. Both simulation study and real data experiments are performed in the fully 3D mode to study the image quality under different system models. The results indicate that the proposed matrix factorization can maintain image quality while substantially reduce the image reconstruction time and system matrix storage cost. The proposed method can be also applied to other PET scanners with DOI measurement.
ERIC Educational Resources Information Center
Halse, M. R.; Hudson, W. J.
1986-01-01
Describes an X-Y scanner used to create acoustic holograms. Scanner is computer controlled and can be adapted to digitize pictures. Scanner geometry is discussed. An appendix gives equipment details. The control program in ATOM BASIC and 6502 machine code is available from the authors. (JM)
Basic study of entire whole-body PET scanners based on the OpenPET geometry
NASA Astrophysics Data System (ADS)
Yoshida, Eiji; Yamaya, Taiga; Nishikido, Fumihiko; Inadama, Naoko; Murayama, Hideo
2010-09-01
A conventional PET scanner has a 15-25 cm axial field-of-view (FOV) and images a whole body using about six bed positions. An OpenPET geometry can extend the axial FOV with a limited number of detectors. The entire whole-body PET scanner must be able to process a large amount of data effectively. In this work, we study feasibility of the fully 3D entire whole-body PET scanner using the GATE simulation. The OpenPET has 12 block detector rings with the ring diameter of 840 mm and each block detector ring consists of 48 depth-of-interaction (DOI) detectors. The OpenPET has the axial length of 895.95 mm with five parts of 58.95 mm open gaps. The OpenPET has higher single data loss than a conventional PET scanner at grouping circuits. NECR of the OpenPET decreases by single data loss. But single data loss is mitigated by separating the axially arranged detector into two parts. Also, multiple coincidences are found to be important for the entire whole-body PET scanner. The entire whole-body PET scanner with the OpenPET geometry promises to provide a large axial FOV with the open space and to have sufficient performance values. But single data loss at the grouping circuits and multiple coincidences are limited to the peak noise equivalent count rate (NECR) for the entire whole-body PET scanner.
Fourier crosstalk analysis of multislice and cone-beam helical CT
NASA Astrophysics Data System (ADS)
La Riviere, Patrick J.
2004-05-01
Multi-slice helical CT scanners allow for much faster scanning and better x-ray utilization than do their single-slice predecessors, but they engender considerably more complicated data sampling patterns due to the interlacing of the samples from different rows as the patient is translated. Characterizing and optimizing this sampling is challenging because the conebeam geometry of such scanners means that the projections measured by each detector row are at least slightly oblique, making it difficult to apply standard multidimensional sampling analyses. In this study, we seek to apply a more general framework for analyzing sampled imaging systems known as Fourier crosstalk analysis. Our purpose in this preliminary work is to compare the information content of the data acquired in three different scanner geometries and operating conditions with ostensibly equivalent volume coverage and average longitudinal sampling interval: a single-slice scanner operating at pitch 1, a four-slice scanner operating at pitch 3 and a 15-slice scanner operating at pitch 15. We find that moving from a single-slice to a multi-slice geometry introduces longitudinal crosstalk characteristic of the longitudinal sampling interval between periods of individual each detector row, and not of the overall interlaced sampling pattern. This is attributed to data inconsistencies caused by the obliqueness of the projections in a multi-slice/conebeam configuration. However, these preliminary results suggest that the significance of this additional crosstalk actually decreases as the number of detector rows increases.
NASA Astrophysics Data System (ADS)
Gagnon, Hugo
This thesis represents a step forward to bring geometry parameterization and control on par with the disciplinary analyses involved in shape optimization, particularly high-fidelity aerodynamic shape optimization. Central to the proposed methodology is the non-uniform rational B-spline, used here to develop a new geometry generator and geometry control system applicable to the aerodynamic design of both conventional and unconventional aircraft. The geometry generator adopts a component-based approach, where any number of predefined but modifiable (parametric) wing, fuselage, junction, etc., components can be arbitrarily assembled to generate the outer mold line of aircraft geometry. A unique Python-based user interface incorporating an interactive OpenGL windowing system is proposed. Together, these tools allow for the generation of high-quality, C2 continuous (or higher), and customized aircraft geometry with fast turnaround. The geometry control system tightly integrates shape parameterization with volume mesh movement using a two-level free-form deformation approach. The framework is augmented with axial curves, which are shown to be flexible and efficient at parameterizing wing systems of arbitrary topology. A key aspect of this methodology is that very large shape deformations can be achieved with only a few, intuitive control parameters. Shape deformation consumes a few tenths of a second on a single processor and surface sensitivities are machine accurate. The geometry control system is implemented within an existing aerodynamic optimizer comprising a flow solver for the Euler equations and a sequential quadratic programming optimizer. Gradients are evaluated exactly with discrete-adjoint variables. The algorithm is first validated by recovering an elliptical lift distribution on a rectangular wing, and then demonstrated through the exploratory shape optimization of a three-pronged feathered winglet leading to a span efficiency of 1.22 under a height-to-span ratio constraint of 0.1. Finally, unconventional aircraft configurations sized for a regional mission are compared against a conventional baseline. Each aircraft is optimized by varying wing section and wing planform (excluding span) under lift and trim constraints at a single operating point. Based on inviscid pressure drag, the box-wing, C-tip blended-wing-body, and braced-wing configurations considered here are respectively 22%, 25%, and 45% more efficient than the tube-and-wing configuration.
Comparison of solid shapes geometry derived by a laser scanner and a total station
NASA Astrophysics Data System (ADS)
Sidiropoulos, Andreas; Lakakis, Konstantinos
2016-08-01
The laser scanning technology has become a common method for the daily applications of a large variety of scientists and professionals. Even for more sophisticated projects, laser scanners have been proved a very useful tool at researchers' and engineers' disposal. In this paper, we investigated the ability of a laser scanner compared to the ability of a total station to provide the geometry of solids. The tests were made in the laboratory facilities of the Aristotle University of Thessaloniki, in a variety of distances between the measuring instrument and the object. The solids that were used differ in shape, material and color. The objects are a wooden cube, a metal cube and a wooden pyramid. The absolute dimensions of the solid shapes were provided by the use of a caliper and were compared to the dimensions that were calculated by the coordinates produced by the total station and laser scanner measurements.
NASA Astrophysics Data System (ADS)
Valentić, Nataša V.; Vitnik, Željko; Kozhushkov, Sergei I.; de Meijere, Armin; Ušćumlić, Gordana S.; Juranić, Ivan O.
2005-06-01
Linear free energy relationships (LFER) were applied to the 1H and 13C NMR chemical shifts ( δN, N= 1H and 13C, respectively) in the unsaturated backbone of cross-conjugated trienes 3-methylene-2-substituted-1,4-pentadienes. The NMR data were correlated using five different LFER models, based on the mono, the dual and the triple substituent parameter (MSP, DSP and TSP, respectively) treatment. The simple and extended Hammett equations, and the three postulated unconventional LFER models obtained by adaptation of the later, were used. The geometry data, which are needed in Karplus-type and McConnell-type analysis, were obtained using semi-empirical MNDO-PM3 calculations. In correlating the data the TSP approach was more successful than the MSP and DSP approaches. The fact that the calculated molecular geometries allow accurate prediction of the NMR data confirms the validity of unconventional LFER models used. These results suggest the s- cis conformation of the cross-conjugated triene as the preferred one. Postulated unconventional DSP and TSP equations enable the assessment of electronic substituent effects in the presence of other interfering influences.
Design of bituminous mixes with high skid resistance.
DOT National Transportation Integrated Search
1979-01-01
Certain highway locations need exceptionally high skid resistance because of the alignment, geometry, and drainage of the roadway and the complex turning maneuvers required. Several beam specimens made of bituminous mixes incorporating unconventional...
DOE Office of Scientific and Technical Information (OSTI.GOV)
Thomas, D; Neylon, J; Dou, T
Purpose: A recently proposed 4D-CT protocol uses deformable registration of free-breathing fast-helical CT scans to generate a breathing motion model. In order to allow accurate registration, free-breathing images are required to be free of doubling-artifacts, which arise when tissue motion is greater than scan speed. This work identifies the minimum scanner parameters required to successfully generate free-breathing fast-helical scans without doubling-artifacts. Methods: 10 patients were imaged under free breathing conditions 25 times in alternating directions with a 64-slice CT scanner using a low dose fast helical protocol. A high temporal resolution (0.1s) 4D-CT was generated using a patient specific motionmore » model and patient breathing waveforms, and used as the input for a scanner simulation. Forward projections were calculated using helical cone-beam geometry (800 projections per rotation) and a GPU accelerated reconstruction algorithm was implemented. Various CT scanner detector widths and rotation times were simulated, and verified using a motion phantom. Doubling-artifacts were quantified in patient images using structural similarity maps to determine the similarity between axial slices. Results: Increasing amounts of doubling-artifacts were observed with increasing rotation times > 0.2s for 16×1mm slice scan geometry. No significant increase in doubling artifacts was observed for 64×1mm slice scan geometry up to 1.0s rotation time although blurring artifacts were observed >0.6s. Using a 16×1mm slice scan geometry, a rotation time of less than 0.3s (53mm/s scan speed) would be required to produce images of similar quality to a 64×1mm slice scan geometry. Conclusion: The current generation of 16 slice CT scanners, which are present in most Radiation Oncology departments, are not capable of generating free-breathing sorting-artifact-free images in the majority of patients. The next generation of CT scanners should be capable of at least 53mm/s scan speed in order to use a fast-helical 4D-CT protocol to generate a motion-artifact free 4D-CT. NIH R01CA096679.« less
Scanner imaging systems, aircraft
NASA Technical Reports Server (NTRS)
Ungar, S. G.
1982-01-01
The causes and effects of distortion in aircraft scanner data are reviewed and an approach to reduce distortions by modelling the effect of aircraft motion on the scanner scene is discussed. With the advent of advanced satellite borne scanner systems, the geometric and radiometric correction of aircraft scanner data has become increasingly important. Corrections are needed to reliably simulate observations obtained by such systems for purposes of evaluation. It is found that if sufficient navigational information is available, aircraft scanner coordinates may be related very precisely to planimetric ground coordinates. However, the potential for a multivalue remapping transformation (i.e., scan lines crossing each other), adds an inherent uncertainty, to any radiometric resampling scheme, which is dependent on the precise geometry of the scan and ground pattern.
Panetta, D; Belcari, N; Del Guerra, A; Bartolomei, A; Salvadori, P A
2012-04-01
This study investigates the reproducibility of the reconstructed image sharpness, after modifications of the geometry setup, for a variable magnification micro-CT (μCT) scanner. All the measurements were performed on a novel engineered μCT scanner for in vivo imaging of small animals (Xalt), which has been recently built at the Institute of Clinical Physiology of the National Research Council (IFC-CNR, Pisa, Italy), in partnership with the University of Pisa. The Xalt scanner is equipped with an integrated software for on-line geometric recalibration, which will be used throughout the experiments. In order to evaluate the losses of image quality due to modifications of the geometry setup, we have made 22 consecutive acquisitions by changing alternatively the system geometry between two different setups (Large FoV - LF, and High Resolution - HR). For each acquisition, the tomographic images have been reconstructed before and after the on-line geometric recalibration. For each reconstruction, the image sharpness was evaluated using two different figures of merit: (i) the percentage contrast on a small bar pattern of fixed frequency (f = 5.5 lp/mm for the LF setup and f = 10 lp/mm for the HR setup) and (ii) the image entropy. We have found that, due to the small-scale mechanical uncertainty (in the order of the voxel size), a recalibration is necessary for each geometric setup after repositioning of the system's components; the resolution losses due to the lack of recalibration are worse for the HR setup (voxel size = 18.4 μm). The integrated on-line recalibration algorithm of the Xalt scanner allowed to perform the recalibration quickly, by restoring the spatial resolution of the system to the reference resolution obtained after the initial (off-line) calibration. Copyright © 2011 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
Superwide-angle coverage code-multiplexed optical scanner.
Riza, Nabeel A; Arain, Muzammil A
2004-05-01
A superwide-angle coverage code-multiplexed optical scanner is presented that has the potential to provide 4 pi-sr coverage. As a proof-of-concept experiment, an angular scan range of 288 degrees for six randomly distributed beams is demonstrated. The proposed scanner achieves its superwide coverage by exploiting a combination of phase-encoded transmission and reflection holography within an in-line hologram recording-retrieval geometry. The basic scanner unit consists of one phase-only digital mode spatial light modulator for code entry (i.e., beam scan control) and a holographic material from which we obtained what we believe is the first-of-a-kind extremely wide coverage, low component count, high speed (e.g., microsecond domain), and large aperture (e.g., > 1-cm diameter) scanner.
Scanning properties of a resonant fiber-optic piezoelectric scanner
NASA Astrophysics Data System (ADS)
Li, Zhi; Yang, Zhe; Fu, Ling
2011-12-01
We develop a resonant fiber-optic scanner using four piezoelectric elements arranged as a square tube, which is efficient to manufacture and drive. Using coupled-field model based on finite element method, scanning properties of the scanner, including vibration mode, resonant frequency, and scanning range, are numerically studied. We also physically measure the effects of geometry sizes and drive signals on the scanning properties, thus providing a foundation for general purpose designs. A scanner adopted in a prototype of imaging system, with a diameter of ˜2 mm and driven by a voltage of 10 V (peak to peak), demonstrates the scanning performance by obtaining an image of resolution target bars. The proposed fiber-optic scanner can be applied to micro-endoscopy that requires two-dimensional scanning of fibers.
Transient beam oscillation with a highly dynamic scanner for laser beam fusion cutting
NASA Astrophysics Data System (ADS)
Goppold, Cindy; Pinder, Thomas; Herwig, Patrick
2016-02-01
Sheet metals with thicknesses >8 mm have a distinct cutting performance. The free choice of the optical configuration composed of fiber diameter, collimation, and focal length offers many opportunities to influence the static beam geometry. Previous analysis points out the limitations of this method in the thick section area. Within the present study, an experimental investigation of fiber laser fusion cutting of 12 mm stainless steel was performed by means of dynamical beam oscillation. Two standard optical setups are combined with a highly dynamic galvano-driven scanner that achieves frequencies up to 4 kHz. Dependencies of the scanner parameter, the optical circumstances, and the conventional cutting parameters are discussed. The aim is to characterize the capabilities and challenges of the dynamic beam shaping in comparison to the state-of-the-art static beam shaping. Thus, the trials are evaluated by quality criteria of the cut edge as surface roughness and burr height, the feed rate, and the cut kerf geometry. The investigation emphasizes promising procedural possibilities for improvements of the cutting performance in the case of fiber laser fusion cutting of thick stainless steel by means of the application of a highly dynamic scanner.
NASA Astrophysics Data System (ADS)
Alevizos, Sotiris; Poulet, Thomas; Sari, Mustafa; Lesueur, Martin; Regenauer-Lieb, Klaus; Veveakis, Manolis
2017-03-01
Understanding the formation, geometry and fluid connectivity of nominally impermeable unconventional shale gas and oil reservoirs is crucial for safe unlocking of these vast energy resources. We present a recent discovery of volumetric instabilities of ductile materials that may explain why impermeable formations become permeable. Here, we present the fundamental mechanisms, the critical parameters and the applicability of the novel theory to unconventional reservoirs. We show that for a reservoir under compaction, there exist certain ambient and permeability conditions at which diagenetic (fluid-release) reactions may provoke channelling localisation instabilities. These channels are periodically interspersed in the matrix and represent areas where the excess fluid from the reaction is segregated at high velocity. We find that channelling instabilities are favoured from pore collapse features for extremely low-permeability formations and fluid-release diagenetic reactions, therefore providing a natural, periodic network of efficient fluid pathways in an otherwise impermeable matrix (i.e. fractures). Such an outcome is of extreme importance the for exploration and extraction phases of unconventional reservoirs.
Nonlocality, no-signalling, and Bellʼs theorem investigated by Weyl conformal differential geometry
NASA Astrophysics Data System (ADS)
De Martini, Francesco; Santamato, Enrico
2014-12-01
The principles and methods of conformal quantum geometrodynamics based on Weyl differential geometry are presented. The theory applied to the case of the relativistic single quantum spin-\\frac{1}{2} leads to a novel and unconventional derivation of the Dirac equation. The further extension of the theory to the case of two-spins-\\frac{1}{2} in the EPR entangled state and to the related violation of Bell inequalities leads, by an exact non-relativistic analysis, to an insightful resolution of all paradoxes implied by quantum nonlocality.
Starting geometry creation and design method for freeform optics.
Bauer, Aaron; Schiesser, Eric M; Rolland, Jannick P
2018-05-01
We describe a method for designing freeform optics based on the aberration theory of freeform surfaces that guides the development of a taxonomy of starting-point geometries with an emphasis on manufacturability. An unconventional approach to the optimization of these starting designs wherein the rotationally invariant 3rd-order aberrations are left uncorrected prior to unobscuring the system is shown to be effective. The optimal starting-point geometry is created for an F/3, 200 mm aperture-class three-mirror imager and is fully optimized using a novel step-by-step method over a 4 × 4 degree field-of-view to exemplify the design method. We then optimize an alternative starting-point geometry that is common in the literature but was quantified here as a sub-optimal candidate for optimization with freeform surfaces. A comparison of the optimized geometries shows the performance of the optimal geometry is at least 16× better, which underscores the importance of the geometry when designing freeform optics.
Unconventional high-Tc superconductivity in fullerides.
Takabayashi, Yasuhiro; Prassides, Kosmas
2016-09-13
A3C60 molecular superconductors share a common electronic phase diagram with unconventional high-temperature superconductors such as the cuprates: superconductivity emerges from an antiferromagnetic strongly correlated Mott-insulating state upon tuning a parameter such as pressure (bandwidth control) accompanied by a dome-shaped dependence of the critical temperature, Tc However, unlike atom-based superconductors, the parent state from which superconductivity emerges solely by changing an electronic parameter-the overlap between the outer wave functions of the constituent molecules-is controlled by the C60 (3-) molecular electronic structure via the on-molecule Jahn-Teller effect influence of molecular geometry and spin state. Destruction of the parent Mott-Jahn-Teller state through chemical or physical pressurization yields an unconventional Jahn-Teller metal, where quasi-localized and itinerant electron behaviours coexist. Localized features gradually disappear with lattice contraction and conventional Fermi liquid behaviour is recovered. The nature of the underlying (correlated versus weak-coupling Bardeen-Cooper-Schrieffer theory) s-wave superconducting states mirrors the unconventional/conventional metal dichotomy: the highest superconducting critical temperature occurs at the crossover between Jahn-Teller and Fermi liquid metal when the Jahn-Teller distortion melts.This article is part of the themed issue 'Fullerenes: past, present and future, celebrating the 30th anniversary of Buckminster Fullerene'. © 2016 The Author(s).
Unconventional high-Tc superconductivity in fullerides
Takabayashi, Yasuhiro; Prassides, Kosmas
2016-01-01
A3C60 molecular superconductors share a common electronic phase diagram with unconventional high-temperature superconductors such as the cuprates: superconductivity emerges from an antiferromagnetic strongly correlated Mott-insulating state upon tuning a parameter such as pressure (bandwidth control) accompanied by a dome-shaped dependence of the critical temperature, Tc. However, unlike atom-based superconductors, the parent state from which superconductivity emerges solely by changing an electronic parameter—the overlap between the outer wave functions of the constituent molecules—is controlled by the C603− molecular electronic structure via the on-molecule Jahn–Teller effect influence of molecular geometry and spin state. Destruction of the parent Mott–Jahn–Teller state through chemical or physical pressurization yields an unconventional Jahn–Teller metal, where quasi-localized and itinerant electron behaviours coexist. Localized features gradually disappear with lattice contraction and conventional Fermi liquid behaviour is recovered. The nature of the underlying (correlated versus weak-coupling Bardeen–Cooper–Schrieffer theory) s-wave superconducting states mirrors the unconventional/conventional metal dichotomy: the highest superconducting critical temperature occurs at the crossover between Jahn–Teller and Fermi liquid metal when the Jahn–Teller distortion melts. This article is part of the themed issue ‘Fullerenes: past, present and future, celebrating the 30th anniversary of Buckminster Fullerene’. PMID:27501971
Poon, Jonathan K; Dahlbom, Magnus L; Moses, William W; Balakrishnan, Karthik; Wang, Wenli; Cherry, Simon R; Badawi, Ramsey D
2012-07-07
The axial field of view (AFOV) of the current generation of clinical whole-body PET scanners range from 15-22 cm, which limits sensitivity and renders applications such as whole-body dynamic imaging or imaging of very low activities in whole-body cellular tracking studies, almost impossible. Generally, extending the AFOV significantly increases the sensitivity and count-rate performance. However, extending the AFOV while maintaining detector thickness has significant cost implications. In addition, random coincidences, detector dead time, and object attenuation may reduce scanner performance as the AFOV increases. In this paper, we use Monte Carlo simulations to find the optimal scanner geometry (i.e. AFOV, detector thickness and acceptance angle) based on count-rate performance for a range of scintillator volumes ranging from 10 to 93 l with detector thickness varying from 5 to 20 mm. We compare the results to the performance of a scanner based on the current Siemens Biograph mCT geometry and electronics. Our simulation models were developed based on individual components of the Siemens Biograph mCT and were validated against experimental data using the NEMA NU-2 2007 count-rate protocol. In the study, noise-equivalent count rate (NECR) was computed as a function of maximum ring difference (i.e. acceptance angle) and activity concentration using a 27 cm diameter, 200 cm uniformly filled cylindrical phantom for each scanner configuration. To reduce the effect of random coincidences, we implemented a variable coincidence time window based on the length of the lines of response, which increased NECR performance up to 10% compared to using a static coincidence time window for scanners with a large maximum ring difference values. For a given scintillator volume, the optimal configuration results in modest count-rate performance gains of up to 16% compared to the shortest AFOV scanner with the thickest detectors. However, the longest AFOV of approximately 2 m with 20 mm thick detectors resulted in performance gains of 25-31 times higher NECR relative to the current Siemens Biograph mCT scanner configuration.
Poon, Jonathan K; Dahlbom, Magnus L; Moses, William W; Balakrishnan, Karthik; Wang, Wenli; Cherry, Simon R; Badawi, Ramsey D
2013-01-01
The axial field of view (AFOV) of the current generation of clinical whole-body PET scanners range from 15–22 cm, which limits sensitivity and renders applications such as whole-body dynamic imaging, or imaging of very low activities in whole-body cellular tracking studies, almost impossible. Generally, extending the AFOV significantly increases the sensitivity and count-rate performance. However, extending the AFOV while maintaining detector thickness has significant cost implications. In addition, random coincidences, detector dead time, and object attenuation may reduce scanner performance as the AFOV increases. In this paper, we use Monte Carlo simulations to find the optimal scanner geometry (i.e. AFOV, detector thickness and acceptance angle) based on count-rate performance for a range of scintillator volumes ranging from 10 to 90 l with detector thickness varying from 5 to 20 mm. We compare the results to the performance of a scanner based on the current Siemens Biograph mCT geometry and electronics. Our simulation models were developed based on individual components of the Siemens Biograph mCT and were validated against experimental data using the NEMA NU-2 2007 count-rate protocol. In the study, noise-equivalent count rate (NECR) was computed as a function of maximum ring difference (i.e. acceptance angle) and activity concentration using a 27 cm diameter, 200 cm uniformly filled cylindrical phantom for each scanner configuration. To reduce the effect of random coincidences, we implemented a variable coincidence time window based on the length of the lines of response, which increased NECR performance up to 10% compared to using a static coincidence time window for scanners with large maximum ring difference values. For a given scintillator volume, the optimal configuration results in modest count-rate performance gains of up to 16% compared to the shortest AFOV scanner with the thickest detectors. However, the longest AFOV of approximately 2 m with 20 mm thick detectors resulted in performance gains of 25–31 times higher NECR relative to the current Siemens Biograph mCT scanner configuration. PMID:22678106
NASA Astrophysics Data System (ADS)
Poon, Jonathan K.; Dahlbom, Magnus L.; Moses, William W.; Balakrishnan, Karthik; Wang, Wenli; Cherry, Simon R.; Badawi, Ramsey D.
2012-07-01
The axial field of view (AFOV) of the current generation of clinical whole-body PET scanners range from 15-22 cm, which limits sensitivity and renders applications such as whole-body dynamic imaging or imaging of very low activities in whole-body cellular tracking studies, almost impossible. Generally, extending the AFOV significantly increases the sensitivity and count-rate performance. However, extending the AFOV while maintaining detector thickness has significant cost implications. In addition, random coincidences, detector dead time, and object attenuation may reduce scanner performance as the AFOV increases. In this paper, we use Monte Carlo simulations to find the optimal scanner geometry (i.e. AFOV, detector thickness and acceptance angle) based on count-rate performance for a range of scintillator volumes ranging from 10 to 93 l with detector thickness varying from 5 to 20 mm. We compare the results to the performance of a scanner based on the current Siemens Biograph mCT geometry and electronics. Our simulation models were developed based on individual components of the Siemens Biograph mCT and were validated against experimental data using the NEMA NU-2 2007 count-rate protocol. In the study, noise-equivalent count rate (NECR) was computed as a function of maximum ring difference (i.e. acceptance angle) and activity concentration using a 27 cm diameter, 200 cm uniformly filled cylindrical phantom for each scanner configuration. To reduce the effect of random coincidences, we implemented a variable coincidence time window based on the length of the lines of response, which increased NECR performance up to 10% compared to using a static coincidence time window for scanners with a large maximum ring difference values. For a given scintillator volume, the optimal configuration results in modest count-rate performance gains of up to 16% compared to the shortest AFOV scanner with the thickest detectors. However, the longest AFOV of approximately 2 m with 20 mm thick detectors resulted in performance gains of 25-31 times higher NECR relative to the current Siemens Biograph mCT scanner configuration.
Geometry induced sequence of nanoscale Frank–Kasper and quasicrystal mesophases in giant surfactants
DOE Office of Scientific and Technical Information (OSTI.GOV)
Yue, Kan; Huang, Mingjun; Marson, Ryan L.
Frank–Kasper (F-K) and quasicrystal phases were originally identified in metal alloys and only sporadically reported in soft materials. These unconventional sphere-packing schemes open up possibilities to design materials with different properties. The challenge in soft materials is how to correlate complex phases built from spheres with the tunable parameters of chemical composition and molecular architecture. Here, we report a complete sequence of various highly ordered mesophases by the self-assembly of specifically designed and synthesized giant surfactants, which are conjugates of hydrophilic polyhedral oligomeric silsesquioxane cages tethered with hydrophobic polystyrene tails. We show that the occurrence of these mesophases results frommore » nanophase separation between the heads and tails and thus is critically dependent on molecular geometry. Variations in molecular geometry achieved by changing the number of tails from one to four not only shift compositional phase boundaries but also stabilize F-K and quasicrystal phases in regions where simple phases of spheroidal micelles are typically observed. These complex self-assembled nanostructures have been identified by combining X-ray scattering techniques and real-space electron microscopy images. Brownian dynamics simulations based on a simplified molecular model confirm the architecture-induced sequence of phases. Our results demonstrate the critical role of molecular architecture in dictating the formation of supramolecular crystals with “soft” spheroidal motifs and provide guidelines to the design of unconventional self-assembled nanostructures.« less
Geometry induced sequence of nanoscale Frank–Kasper and quasicrystal mesophases in giant surfactants
Yue, Kan; Huang, Mingjun; Marson, Ryan L.; He, Jinlin; Huang, Jiahao; Zhou, Zhe; Wang, Jing; Liu, Chang; Yan, Xuesheng; Wu, Kan; Guo, Zaihong; Liu, Hao; Ni, Peihong; Wesdemiotis, Chrys; Zhang, Wen-Bin; Glotzer, Sharon C.; Cheng, Stephen Z. D.
2016-01-01
Frank–Kasper (F-K) and quasicrystal phases were originally identified in metal alloys and only sporadically reported in soft materials. These unconventional sphere-packing schemes open up possibilities to design materials with different properties. The challenge in soft materials is how to correlate complex phases built from spheres with the tunable parameters of chemical composition and molecular architecture. Here, we report a complete sequence of various highly ordered mesophases by the self-assembly of specifically designed and synthesized giant surfactants, which are conjugates of hydrophilic polyhedral oligomeric silsesquioxane cages tethered with hydrophobic polystyrene tails. We show that the occurrence of these mesophases results from nanophase separation between the heads and tails and thus is critically dependent on molecular geometry. Variations in molecular geometry achieved by changing the number of tails from one to four not only shift compositional phase boundaries but also stabilize F-K and quasicrystal phases in regions where simple phases of spheroidal micelles are typically observed. These complex self-assembled nanostructures have been identified by combining X-ray scattering techniques and real-space electron microscopy images. Brownian dynamics simulations based on a simplified molecular model confirm the architecture-induced sequence of phases. Our results demonstrate the critical role of molecular architecture in dictating the formation of supramolecular crystals with “soft” spheroidal motifs and provide guidelines to the design of unconventional self-assembled nanostructures. PMID:27911786
Two-dimensional imaging in a lightweight portable MRI scanner without gradient coils.
Cooley, Clarissa Zimmerman; Stockmann, Jason P; Armstrong, Brandon D; Sarracanie, Mathieu; Lev, Michael H; Rosen, Matthew S; Wald, Lawrence L
2015-02-01
As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations such as intensive care units, physician offices, surgical suites, ambulances, emergency rooms, sports facilities, or rural healthcare sites. We construct and validate a truly portable (<100 kg) and silent proof-of-concept MRI scanner which replaces conventional gradient encoding with a rotating lightweight cryogen-free, low-field magnet. When rotated about the object, the inhomogeneous field pattern is used as a rotating spatial encoding magnetic field (rSEM) to create generalized projections which encode the iteratively reconstructed two-dimensional (2D) image. Multiple receive channels are used to disambiguate the nonbijective encoding field. The system is validated with experimental images of 2D test phantoms. Similar to other nonlinear field encoding schemes, the spatial resolution is position dependent with blurring in the center, but is shown to be likely sufficient for many medical applications. The presented MRI scanner demonstrates the potential for portability by simultaneously relaxing the magnet homogeneity criteria and eliminating the gradient coil. This new architecture and encoding scheme shows convincing proof of concept images that are expected to be further improved with refinement of the calibration and methodology. © 2014 Wiley Periodicals, Inc.
2D Imaging in a Lightweight Portable MRI Scanner without Gradient Coils
Cooley, Clarissa Zimmerman; Stockmann, Jason P.; Armstrong, Brandon D.; Sarracanie, Mathieu; Lev, Michael H.; Rosen, Matthew S.; Wald, Lawrence L.
2014-01-01
Purpose As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations such as Intensive Care Units, physician offices, surgical suites, ambulances, emergency rooms, sports facilities, or rural healthcare sites. Methods We construct and validate a truly portable (<100kg) and silent proof-of-concept MRI scanner which replaces conventional gradient encoding with a rotating lightweight cryogen-free, low-field magnet. When rotated about the object, the inhomogeneous field pattern is used as a rotating Spatial Encoding Magnetic field (rSEM) to create generalized projections which encode the iteratively reconstructed 2D image. Multiple receive channels are used to disambiguate the non-bijective encoding field. Results The system is validated with experimental images of 2D test phantoms. Similar to other non-linear field encoding schemes, the spatial resolution is position dependent with blurring in the center, but is shown to be likely sufficient for many medical applications. Conclusion The presented MRI scanner demonstrates the potential for portability by simultaneously relaxing the magnet homogeneity criteria and eliminating the gradient coil. This new architecture and encoding scheme shows convincing proof of concept images that are expected to be further improved with refinement of the calibration and methodology. PMID:24668520
A new scanning device in CT with dose reduction potential
NASA Astrophysics Data System (ADS)
Tischenko, Oleg; Xu, Yuan; Hoeschen, Christoph
2006-03-01
The amount of x-ray radiation currently applied in CT practice is not utilized optimally. A portion of radiation traversing the patient is either not detected at all or is used ineffectively. The reason lies partly in the reconstruction algorithms and partly in the geometry of the CT scanners designed specifically for these algorithms. In fact, the reconstruction methods widely used in CT are intended to invert the data that correspond to ideal straight lines. However, the collection of such data is often not accurate due to likely movement of the source/detector system of the scanner in the time interval during which all the detectors are read. In this paper, a new design of the scanner geometry is proposed that is immune to the movement of the CT system and will collect all radiation traversing the patient. The proposed scanning design has a potential to reduce the patient dose by a factor of two. Furthermore, it can be used with the existing reconstruction algorithm and it is particularly suitable for OPED, a new robust reconstruction algorithm.
Topological Magnon Bands and Unconventional Superconductivity in Pyrochlore Iridate Thin Films.
Laurell, Pontus; Fiete, Gregory A
2017-04-28
We theoretically study the magnetic properties of pyrochlore iridate bilayer and trilayer thin films grown along the [111] direction using a strong coupling approach. We find the ground state magnetic configurations on a mean field level and carry out a spin-wave analysis about them. In the trilayer case the ground state is found to be the all-in-all-out (AIAO) state, whereas the bilayer has a deformed AIAO state. For all parameters of the spin-orbit coupled Hamiltonian we study, the lowest magnon band in the trilayer case has a nonzero Chern number. In the bilayer case we also find a parameter range with nonzero Chern numbers. We calculate the magnon Hall response for both geometries, finding a striking sign change as a function of temperature. Using a slave-boson mean-field theory we study the doping of the trilayer system and discover an unconventional time-reversal symmetry broken d+id superconducting state. Our study complements prior work in the weak coupling limit and suggests that the [111] grown thin film pyrochlore iridates are a promising candidate for topological properties and unconventional orders.
NASA Astrophysics Data System (ADS)
Tak, Heewon; Choi, Jaewon; Jo, Sohyun; Hwang, Sukyeon
2017-04-01
Stress anisotropy analysis is important for estimating both stress regime and fracture geometry for the efficient development of unconventional resources. Despite being within the same play, different areas can have different stress regimes, which can affect drilling decisions. The Montney play is located in Canada between British Columbia and Alberta. In British Columbia it is known for its ductile shale and high horizontal stress anisotropy because of the Rocky Mountains; however, in Alberta, it has different geological characteristics with some studies finding weak horizontal stress anisotropy. Therefore, we studied the horizontal stress anisotropy using full azimuth seismic and well data in the Kakwa area in order to establish a drilling plan. Minimal horizontal anisotropy was discovered within the area and the direction of maximum horizontal anisotropy corresponded with the regional scale (i.e., NE-SW). The induced fractures were assumed to have a normal stress regime because of the large depth (> 3000 m). Additionally, because of the very high brittleness (Young's modulus > 9) and relatively weak horizontal stress anisotropy, the fracture geometry in the Kakwa area was estimated as complex or complex planar, as opposed to simply planar.
Adaptive Modeling, Engineering Analysis and Design of Advanced Aerospace Vehicles
NASA Technical Reports Server (NTRS)
Mukhopadhyay, Vivek; Hsu, Su-Yuen; Mason, Brian H.; Hicks, Mike D.; Jones, William T.; Sleight, David W.; Chun, Julio; Spangler, Jan L.; Kamhawi, Hilmi; Dahl, Jorgen L.
2006-01-01
This paper describes initial progress towards the development and enhancement of a set of software tools for rapid adaptive modeling, and conceptual design of advanced aerospace vehicle concepts. With demanding structural and aerodynamic performance requirements, these high fidelity geometry based modeling tools are essential for rapid and accurate engineering analysis at the early concept development stage. This adaptive modeling tool was used for generating vehicle parametric geometry, outer mold line and detailed internal structural layout of wing, fuselage, skin, spars, ribs, control surfaces, frames, bulkheads, floors, etc., that facilitated rapid finite element analysis, sizing study and weight optimization. The high quality outer mold line enabled rapid aerodynamic analysis in order to provide reliable design data at critical flight conditions. Example application for structural design of a conventional aircraft and a high altitude long endurance vehicle configuration are presented. This work was performed under the Conceptual Design Shop sub-project within the Efficient Aerodynamic Shape and Integration project, under the former Vehicle Systems Program. The project objective was to design and assess unconventional atmospheric vehicle concepts efficiently and confidently. The implementation may also dramatically facilitate physics-based systems analysis for the NASA Fundamental Aeronautics Mission. In addition to providing technology for design and development of unconventional aircraft, the techniques for generation of accurate geometry and internal sub-structure and the automated interface with the high fidelity analysis codes could also be applied towards the design of vehicles for the NASA Exploration and Space Science Mission projects.
3D Digital Surveying and Modelling of Cave Geometry: Application to Paleolithic Rock Art.
González-Aguilera, Diego; Muñoz-Nieto, Angel; Gómez-Lahoz, Javier; Herrero-Pascual, Jesus; Gutierrez-Alonso, Gabriel
2009-01-01
3D digital surveying and modelling of cave geometry represents a relevant approach for research, management and preservation of our cultural and geological legacy. In this paper, a multi-sensor approach based on a terrestrial laser scanner, a high-resolution digital camera and a total station is presented. Two emblematic caves of Paleolithic human occupation and situated in northern Spain, "Las Caldas" and "Peña de Candamo", have been chosen to put in practise this approach. As a result, an integral and multi-scalable 3D model is generated which may allow other scientists, pre-historians, geologists…, to work on two different levels, integrating different Paleolithic Art datasets: (1) a basic level based on the accurate and metric support provided by the laser scanner; and (2) a advanced level using the range and image-based modelling.
Real-Time Mapping Using Stereoscopic Vision Optimization
2005-03-01
pinhole geometry . . . . . . . . . . . . . . 17 2.8. Artificially textured scenes . . . . . . . . . . . . . . . . . . . . 23 3.1. Bilbo the robot...geometry. 2.2.1 The Fundamental Matrix. The fundamental matrix (F) describes the relationship between a pair of 2D pictures of a 3D scene . This is...eight CCD cameras to compute a mesh model of the environment from a large number of overlapped 3D images. In [1,17], a range scanner is combined with a
Optimized unconventional superconductivity in a molecular Jahn-Teller metal
Zadik, Ruth H.; Takabayashi, Yasuhiro; Klupp, Gyöngyi; Colman, Ross H.; Ganin, Alexey Y.; Potočnik, Anton; Jeglič, Peter; Arčon, Denis; Matus, Péter; Kamarás, Katalin; Kasahara, Yuichi; Iwasa, Yoshihiro; Fitch, Andrew N.; Ohishi, Yasuo; Garbarino, Gaston; Kato, Kenichi; Rosseinsky, Matthew J.; Prassides, Kosmas
2015-01-01
Understanding the relationship between the superconducting, the neighboring insulating, and the normal metallic state above Tc is a major challenge for all unconventional superconductors. The molecular A3C60 fulleride superconductors have a parent antiferromagnetic insulator in common with the atom-based cuprates, but here, the C603– electronic structure controls the geometry and spin state of the structural building unit via the on-molecule Jahn-Teller effect. We identify the Jahn-Teller metal as a fluctuating microscopically heterogeneous coexistence of both localized Jahn-Teller–active and itinerant electrons that connects the insulating and superconducting states of fullerides. The balance between these molecular and extended lattice features of the electrons at the Fermi level gives a dome-shaped variation of Tc with interfulleride separation, demonstrating molecular electronic structure control of superconductivity. PMID:26601168
A prototype table-top inverse-geometry volumetric CT system.
Schmidt, Taly Gilat; Star-Lack, Josh; Bennett, N Robert; Mazin, Samuel R; Solomon, Edward G; Fahrig, Rebecca; Pelc, Norbert J
2006-06-01
A table-top volumetric CT system has been implemented that is able to image a 5-cm-thick volume in one circular scan with no cone-beam artifacts. The prototype inverse-geometry CT (IGCT) scanner consists of a large-area, scanned x-ray source and a detector array that is smaller in the transverse direction. The IGCT geometry provides sufficient volumetric sampling because the source and detector have the same axial, or slice direction, extent. This paper describes the implementation of the table-top IGCT scanner, which is based on the NexRay Scanning-Beam Digital X-ray system (NexRay, Inc., Los Gatos, CA) and an investigation of the system performance. The alignment and flat-field calibration procedures are described, along with a summary of the reconstruction algorithm. The resolution and noise performance of the prototype IGCT system are studied through experiments and further supported by analytical predictions and simulations. To study the presence of cone-beam artifacts, a "Defrise" phantom was scanned on both the prototype IGCT scanner and a micro CT system with a +/-5 cone angle for a 4.5-cm volume thickness. Images of inner ear specimens are presented and compared to those from clinical CT systems. Results showed that the prototype IGCT system has a 0.25-mm isotropic resolution and that noise comparable to that from a clinical scanner with equivalent spatial resolution is achievable. The measured MTF and noise values agreed reasonably well with theoretical predictions and computer simulations. The IGCT system was able to faithfully reconstruct the laminated pattern of the Defrise phantom while the micro CT system suffered severe cone-beam artifacts for the same object. The inner ear acquisition verified that the IGCT system can image a complex anatomical object, and the resulting images exhibited more high-resolution details than the clinical CT acquisition. Overall, the successful implementation of the prototype system supports the IGCT concept for single-rotation volumetric scanning free from cone-beam artifacts.
ERIC Educational Resources Information Center
Vail, Kathleen
1995-01-01
Biometrics (hand geometry, iris and retina scanners, voice and facial recognition, signature dynamics, facial thermography, and fingerprint readers) identifies people based on physical characteristics. Administrators worried about kidnapping, vandalism, theft, and violent intruders might welcome these security measures when they become more…
3D Digital Surveying and Modelling of Cave Geometry: Application to Paleolithic Rock Art
González-Aguilera, Diego; Muñoz-Nieto, Angel; Gómez-Lahoz, Javier; Herrero-Pascual, Jesus; Gutierrez-Alonso, Gabriel
2009-01-01
3D digital surveying and modelling of cave geometry represents a relevant approach for research, management and preservation of our cultural and geological legacy. In this paper, a multi-sensor approach based on a terrestrial laser scanner, a high-resolution digital camera and a total station is presented. Two emblematic caves of Paleolithic human occupation and situated in northern Spain, “Las Caldas” and “Peña de Candamo”, have been chosen to put in practise this approach. As a result, an integral and multi-scalable 3D model is generated which may allow other scientists, pre-historians, geologists…, to work on two different levels, integrating different Paleolithic Art datasets: (1) a basic level based on the accurate and metric support provided by the laser scanner; and (2) a advanced level using the range and image-based modelling. PMID:22399958
Performance evaluation of a LYSO-based PET scanner for monitoring of dose delivery in hadrontherapy
NASA Astrophysics Data System (ADS)
Fabbiani, E.; Belcari, N.; Camarlinghi, N.; Del Guerra, A.; Ferretti, S.; Kraan, A.; Panetta, D.; Sportelli, G.; Rosso, V.
2015-12-01
The DoPET scanner is a compact positron emission tomography (PET) device. It has been developed for monitoring the range of charged particles during therapy with hadron beams. Previous works have focused on the development and upgrade of the device and on data analysis. In this paper, a full performance characterization of the DoPET system in terms of the energy resolution, spatial resolution, sensitivity, uniformity, and noise equivalent count rate is reported. All measurements refer to an adapted version of the National Electrical Manufacturers Association (NEMA) NU 4 - 2008 protocol, which was written originally for small animal PET systems. Since DoPET is a dual head planar system, it requires a modified characterisation procedure with respect to those described for ring geometries as in the NEMA NU 4 - 2008 protocol. The presented procedure may be of interest for any other PET system with a similar geometry as DoPET.
Abella, M; Vicente, E; Rodríguez-Ruano, A; España, S; Lage, E; Desco, M; Udias, J M; Vaquero, J J
2012-11-21
Technological advances have improved the assembly process of PET detectors, resulting in quite small mechanical tolerances. However, in high-spatial-resolution systems, even submillimetric misalignments of the detectors may lead to a notable degradation of image resolution and artifacts. Therefore, the exact characterization of misalignments is critical for optimum reconstruction quality in such systems. This subject has been widely studied for CT and SPECT scanners based on cone beam geometry, but this is not the case for PET tomographs based on rotating planar detectors. The purpose of this work is to analyze misalignment effects in these systems and to propose a robust and easy-to-implement protocol for geometric characterization. The result of the proposed calibration method, which requires no more than a simple calibration phantom, can then be used to generate a correct 3D-sinogram from the acquired list mode data.
NASA Astrophysics Data System (ADS)
Raylman, Raymond R.; Stolin, Alexander V.; Sompalli, Prashanth; Randall, Nicole Bunda; Martone, Peter F.; Clinthorne, Neal H.
2015-10-01
Staging of head and neck cancer (HNC) is often hindered by the limited resolution of standard whole body PET scanners, which can make it challenging to detect small areas of metastatic disease in regional lymph nodes and accurately delineate tumor boundaries. In this investigation, the performance of a proposed high resolution PET/CT scanner designed specifically for imaging of the head and neck region was explored. The goal is to create a dedicated PET/CT system that will enhance the staging and treatment of HNCs. Its performance was assessed by simulating the scanning of a three-dimensional Rose-Burger contrast phantom. To extend the results from the simulation studies, an existing scanner with a similar geometry to the dedicated system and a whole body, clinical PET/CT scanner were used to image a Rose-Burger contrast phantom and a phantom simulating the neck of an HNC patient (out-of-field-of-view sources of activity were not included). Images of the contrast detail phantom acquired with Breast-PET/CT and simulated head and neck scanner both produced object contrasts larger than the images created by the clinical scanner. Images of a neck phantom acquired with the Breast-PET/CT scanner permitted the identification of all of the simulated metastases, while it was not possible to identify any of the simulated metastasis with the clinical scanner. The initial results from this study demonstrate the potential benefits of high-resolution PET systems for improving the diagnosis and treatment of HNC.
Panoramic 3D Reconstruction by Fusing Color Intensity and Laser Range Data
NASA Astrophysics Data System (ADS)
Jiang, Wei; Lu, Jian
Technology for capturing panoramic (360 degrees) three-dimensional information in a real environment have many applications in fields: virtual and complex reality, security, robot navigation, and so forth. In this study, we examine an acquisition device constructed of a regular CCD camera and a 2D laser range scanner, along with a technique for panoramic 3D reconstruction using a data fusion algorithm based on an energy minimization framework. The acquisition device can capture two types of data of a panoramic scene without occlusion between two sensors: a dense spatio-temporal volume from a camera and distance information from a laser scanner. We resample the dense spatio-temporal volume for generating a dense multi-perspective panorama that has equal spatial resolution to that of the original images acquired using a regular camera, and also estimate a dense panoramic depth-map corresponding to the generated reference panorama by extracting trajectories from the dense spatio-temporal volume with a selecting camera. Moreover, for determining distance information robustly, we propose a data fusion algorithm that is embedded into an energy minimization framework that incorporates active depth measurements using a 2D laser range scanner and passive geometry reconstruction from an image sequence obtained using the CCD camera. Thereby, measurement precision and robustness can be improved beyond those available by conventional methods using either passive geometry reconstruction (stereo vision) or a laser range scanner. Experimental results using both synthetic and actual images show that our approach can produce high-quality panoramas and perform accurate 3D reconstruction in a panoramic environment.
NASA Astrophysics Data System (ADS)
Youn, Dong Joon
This thesis presents the development and validation of an advanced hydro-mechanical coupled finite element program analyzing hydraulic fracture propagation within unconventional hydrocarbon formations under various conditions. The realistic modeling of hydraulic fracturing is necessarily required to improve the understanding and efficiency of the stimulation technique. Such modeling remains highly challenging, however, due to factors including the complexity of fracture propagation mechanisms, the coupled behavior of fracture displacement and fluid pressure, the interactions between pre-existing natural and initiated hydraulic fractures and the formation heterogeneity of the target reservoir. In this research, an eXtended Finite Element Method (XFEM) scheme is developed allowing for representation of single or multiple fracture propagations without any need for re-meshing. Also, the coupled flows through the fracture are considered in the program to account for their influence on stresses and deformations along the hydraulic fracture. In this research, a sequential coupling scheme is applied to estimate fracture aperture and fluid pressure with the XFEM. Later, the coupled XFEM program is used to estimate wellbore bottomhole pressure during fracture propagation, and the pressure variations are analyzed to determine the geometry and performance of the hydraulic fracturing as pressure leak-off test. Finally, material heterogeneity is included into the XFEM program to check the effect of random formation property distributions to the hydraulic fracture geometry. Random field theory is used to create the random realization of the material heterogeneity with the consideration of mean, standard deviation, and property correlation length. These analyses lead to probabilistic information on the response of unconventional reservoirs and offer a more scientific approach regarding risk management for the unconventional reservoir stimulation. The new stochastic approach combining XFEM and random field is named as eXtended Random Finite Element Method (XRFEM). All the numerical analysis codes in this thesis are written in Fortran 2003, and these codes are applicable as a series of sub-modules within a suite of finite element codes developed by Smith and Griffiths (2004).
NASA Technical Reports Server (NTRS)
Malila, W. A.; Cicone, R. C.; Gleason, J. M.
1976-01-01
Simulated scanner system data values generated in support of LACIE (Large Area Crop Inventory Experiment) research and development efforts are presented. Synthetic inband (LANDSAT) wheat radiances and radiance components were computed and are presented for various wheat canopy and atmospheric conditions and scanner view geometries. Values include: (1) inband bidirectional reflectances for seven stages of wheat crop growth; (2) inband atmospheric features; and (3) inband radiances corresponding to the various combinations of wheat canopy and atmospheric conditions. Analyses of these data values are presented in the main report.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Nomura, Yasunori; Salzetta, Nico; Sanches, Fabio
We study the Hilbert space structure of classical spacetimes under the assumption that entanglement in holographic theories determines semiclassical geometry. We show that this simple assumption has profound implications; for example, a superposition of classical spacetimes may lead to another classical spacetime. Despite its unconventional nature, this picture admits the standard interpretation of superpositions of well-defined semiclassical spacetimes in the limit that the number of holographic degrees of freedom becomes large. We illustrate these ideas using a model for the holographic theory of cosmological spacetimes.
On the Use of Parmetric-CAD Systems and Cartesian Methods for Aerodynamic Design
NASA Technical Reports Server (NTRS)
Nemec, Marian; Aftosmis, Michael J.; Pulliam, Thomas H.
2004-01-01
Automated, high-fidelity tools for aerodynamic design face critical issues in attempting to optimize real-life geometry arid in permitting radical design changes. Success in these areas promises not only significantly shorter design- cycle times, but also superior and unconventional designs. To address these issues, we investigate the use of a parmetric-CAD system in conjunction with an embedded-boundary Cartesian method. Our goal is to combine the modeling capabilities of feature-based CAD with the robustness and flexibility of component-based Cartesian volume-mesh generation for complex geometry problems. We present the development of an automated optimization frame-work with a focus on the deployment of such a CAD-based design approach in a heterogeneous parallel computing environment.
Evaluation of PeneloPET Simulations of Biograph PET/CT Scanners
NASA Astrophysics Data System (ADS)
Abushab, K. M.; Herraiz, J. L.; Vicente, E.; Cal-González, J.; España, S.; Vaquero, J. J.; Jakoby, B. W.; Udías, J. M.
2016-06-01
Monte Carlo (MC) simulations are widely used in positron emission tomography (PET) for optimizing detector design, acquisition protocols, and evaluating corrections and reconstruction methods. PeneloPET is a MC code based on PENELOPE, for PET simulations which considers detector geometry, acquisition electronics and materials, and source definitions. While PeneloPET has been successfully employed and validated with small animal PET scanners, it required a proper validation with clinical PET scanners including time-of-flight (TOF) information. For this purpose, we chose the family of Biograph PET/CT scanners: the Biograph True-Point (B-TP), Biograph True-Point with TrueV (B-TPTV) and the Biograph mCT. They have similar block detectors and electronics, but a different number of rings and configuration. Some effective parameters of the simulations, such as the dead-time and the size of the reflectors in the detectors, were adjusted to reproduce the sensitivity and noise equivalent count (NEC) rate of the B-TPTV scanner. These parameters were then used to make predictions of experimental results such as sensitivity, NEC rate, spatial resolution, and scatter fraction (SF), from all the Biograph scanners and some variations of them (energy windows and additional rings of detectors). Predictions agree with the measured values for the three scanners, within 7% (sensitivity and NEC rate) and 5% (SF). The resolution obtained for the B-TPTV is slightly better (10%) than the experimental values. In conclusion, we have shown that PeneloPET is suitable for simulating and investigating clinical systems with good accuracy and short computational time, though some effort tuning of a few parameters of the scanners modeled may be needed in case that the full details of the scanners studied are not available.
Geometric and Colour Data Fusion for Outdoor 3D Models
Merchán, Pilar; Adán, Antonio; Salamanca, Santiago; Domínguez, Vicente; Chacón, Ricardo
2012-01-01
This paper deals with the generation of accurate, dense and coloured 3D models of outdoor scenarios from scanners. This is a challenging research field in which several problems still remain unsolved. In particular, the process of 3D model creation in outdoor scenes may be inefficient if the scene is digitalized under unsuitable technical (specific scanner on-board camera) and environmental (rain, dampness, changing illumination) conditions. We address our research towards the integration of images and range data to produce photorealistic models. Our proposal is based on decoupling the colour integration and geometry reconstruction stages, making them independent and controlled processes. This issue is approached from two different viewpoints. On the one hand, given a complete model (geometry plus texture), we propose a method to modify the original texture provided by the scanner on-board camera with the colour information extracted from external images taken at given moments and under specific environmental conditions. On the other hand, we propose an algorithm to directly assign external images onto the complete geometric model, thus avoiding tedious on-line calibration processes. We present the work conducted on two large Roman archaeological sites dating from the first century A.D., namely, the Theatre of Segobriga and the Fori Porticus of Emerita Augusta, both in Spain. The results obtained demonstrate that our approach could be useful in the digitalization and 3D modelling fields. PMID:22969327
Real Time Coincidence Detection Engine for High Count Rate Timestamp Based PET
NASA Astrophysics Data System (ADS)
Tetrault, M.-A.; Oliver, J. F.; Bergeron, M.; Lecomte, R.; Fontaine, R.
2010-02-01
Coincidence engines follow two main implementation flows: timestamp based systems and AND-gate based systems. The latter have been more widespread in recent years because of its lower cost and high efficiency. However, they are highly dependent on the selected electronic components, they have limited flexibility once assembled and they are customized to fit a specific scanner's geometry. Timestamp based systems are gathering more attention lately, especially with high channel count fully digital systems. These new systems must however cope with important singles count rates. One option is to record every detected event and postpone coincidence detection offline. For daily use systems, a real time engine is preferable because it dramatically reduces data volume and hence image preprocessing time and raw data management. This paper presents the timestamp based coincidence engine for the LabPET¿, a small animal PET scanner with up to 4608 individual readout avalanche photodiode channels. The engine can handle up to 100 million single events per second and has extensive flexibility because it resides in programmable logic devices. It can be adapted for any detector geometry or channel count, can be ported to newer, faster programmable devices and can have extra modules added to take advantage of scanner-specific features. Finally, the user can select between full processing mode for imaging protocols and minimum processing mode to study different approaches for coincidence detection with offline software.
Interpretation of Quantum Nonlocality by Conformal Quantum Geometrodynamics
NASA Astrophysics Data System (ADS)
De Martini, Francesco; Santamato, Enrico
2014-10-01
The principles and methods of the Conformal Quantum Geometrodynamics (CQG) based on the Weyl's differential geometry are presented. The theory applied to the case of the relativistic single quantum spin leads a novel and unconventional derivation of Dirac's equation. The further extension of the theory to the case of two spins in EPR entangled state and to the related violation of Bell's inequalities leads, by a non relativistic analysis, to an insightful resolution of the enigma implied by quantum nonlocality.
Ghoshhajra, Brian B; Sidhu, Manavjot S; El-Sherief, Ahmed; Rojas, Carlos; Yeh, Doreen Defaria; Engel, Leif-Christopher; Liberthson, Richard; Abbara, Suhny; Bhatt, Ami
2012-01-01
Adult congenital heart disease patients present a unique challenge to the cardiac imager. Patients may present with both acute and chronic manifestations of their complex congenital heart disease and also require surveillance for sequelae of their medical and surgical interventions. Multimodality imaging is often required to clarify their anatomy and physiology. Radiation dose is of particular concern in these patients with lifelong imaging needs for their chronic disease. The second-generation dual-source scanner is a recently available advanced clinical cardiac computed tomography (CT) scanner. It offers a combination of the high-spatial resolution of modern CT, the high-temporal resolution of dual-source technology, and the wide z-axis coverage of modern cone-beam geometry CT scanners. These advances in technology allow novel protocols that markedly reduce scan time, significantly reduce radiation exposure, and expand the physiologic imaging capabilities of cardiac CT. We present a case series of complicated adult congenital heart disease patients imaged by the second-generation dual-source CT scanner with extremely low-radiation doses and excellent image quality. © 2012 Wiley Periodicals, Inc.
Green, Michael V.; Ostrow, Harold G.; Seidel, Jurgen; Pomper, Martin G.
2013-01-01
Human and small-animal positron emission tomography (PET) scanners with cylindrical geometry and conventional detectors exhibit a progressive reduction in radial spatial resolution with increasing radial distance from the geometric axis of the scanner. This “depth-of-interaction” (DOI) effect is sufficiently deleterious that many laboratories have devised novel schemes to reduce the magnitude of this effect and thereby yield PET images of greater quantitative accuracy. Here we examine experimentally the effects of a particular DOI correction method (dual-scintillator phoswich detectors with pulse shape discrimination) implemented in a small-animal PET scanner by comparing the same phantom and same mouse images with and without DOI correction. The results suggest that even this relatively coarse, two-level estimate of radial gamma ray interaction position significantly reduces the DOI parallax error. This study also confirms two less appreciated advantages of DOI correction: a reduction in radial distortion and radial source displacement as a source is moved toward the edge of the field of view and a resolution improvement detectable in the central field of view likely owing to improved spatial sampling. PMID:21084028
Green, Michael V; Ostrow, Harold G; Seidel, Jurgen; Pomper, Martin G
2010-12-01
Human and small-animal positron emission tomography (PET) scanners with cylindrical geometry and conventional detectors exhibit a progressive reduction in radial spatial resolution with increasing radial distance from the geometric axis of the scanner. This "depth-of-interaction" (DOI) effect is sufficiently deleterious that many laboratories have devised novel schemes to reduce the magnitude of this effect and thereby yield PET images of greater quantitative accuracy. Here we examine experimentally the effects of a particular DOI correction method (dual-scintillator phoswich detectors with pulse shape discrimination) implemented in a small-animal PET scanner by comparing the same phantom and same mouse images with and without DOI correction. The results suggest that even this relatively coarse, two-level estimate of radial gamma ray interaction position significantly reduces the DOI parallax error. This study also confirms two less appreciated advantages of DOI correction: a reduction in radial distortion and radial source displacement as a source is moved toward the edge of the field of view and a resolution improvement detectable in the central field of view likely owing to improved spatial sampling.
Modification of a medical PET scanner for PEPT studies
NASA Astrophysics Data System (ADS)
Sadrmomtaz, Alireza; Parker, D. J.; Byars, L. G.
2007-04-01
Over the last 20 years, positron emission tomography (PET) has developed as the most powerful functional imaging modality in medicine. Over the same period the University of Birmingham Positron Imaging Centre has applied PET to study engineering processes and developed the alternative technique of positron emission particle tracking (PEPT) in which a single radioactively labelled tracer particle is tracked by detecting simultaneously the pairs of back-to-back photons arising from positron/electron annihilation. Originally PEPT was performed using a pair of multiwire detectors, and more recently using a pair of digital gamma camera heads. In 2002 the Positron Imaging Centre acquired a medical PET scanner, an ECAT 931/08, previously used at Hammersmith Hospital. This scanner has been rebuilt in a flexible geometry for use in PEPT studies. This paper presents initial results from this system. Fast moving tracer particles can be rapidly and accurately located.
NASA Astrophysics Data System (ADS)
Zarian, P.; Casey, J. F.; Miller, J.
2002-12-01
One of the unconventional research efforts that have been directed to reveal the structure of the lower oceanic crust is the application of Formation MicroScanner log in an ultra-slow spreading environment. Hole 1105A was cored during ODP Leg 179 to a depth of 158m on the Atlantis Platform in the Southwest Indian Ridge with a relative high recovery of 82.8% of gabbroic rocks. Open-hole logs, including FMS borehole images were acquired after the coring operation. Detailed modal, grain size and microstructural analyses of 147 thin sections reveal the relationships between deformation intensity, modal composition and rheology. The microstructural analyses showed that the majority of the oxide-rich gabbros exhibit high deformation intensity textures, which are present only in a few of the oxide-free gabbros. The oxide-rich gabbros represent ductile deformation zones and control the location of major deformation zones within these rocks. Oxide-rich layers can be clearly identified on electrical images and enabled the identification of different deformation features.The calibration of borehole images with core data provides us with more detailed information about the geometry of these oxide-rich layers within the magma chamber such as the dip and true pseudo-stratigraphic thickness of these layers. Also within the intervals of no core recovery, electrical images provide valuable information of the borehole wall. Brittle deformation features such as natural mineralized fractures can be documented throughout the borehole. Statistical results show that oxide-rich layers are relatively steep with an average dip of about 50 degrees and have a dominant E-W strike which is parallel to the ridge. These layers may represent the insitu crystallization of cummulate layers on a magma chamber wall elongated parallel to the ridge, or they may represent shear zones associated with near surface high angle normal faults that cut the main low angle detachment surface which caused the unroofing of the lower oceanic crust at the inner corner of the Ridge-Transform Intersection. These ductile shear zones appear to strike in a ridge parallel orientation, may have acted as syntectonic permeable pathways for fractionated melts infiltrated during the unroofing. Core-log integration also demonstrates the capabilities of electrical borehole images for structural analyses within a hard rock environment.
Multisource inverse-geometry CT. Part I. System concept and development
DOE Office of Scientific and Technical Information (OSTI.GOV)
De Man, Bruno, E-mail: deman@ge.com; Harrison, Dan
Purpose: This paper presents an overview of multisource inverse-geometry computed tomography (IGCT) as well as the development of a gantry-based research prototype system. The development of the distributed x-ray source is covered in a companion paper [V. B. Neculaes et al., “Multisource inverse-geometry CT. Part II. X-ray source design and prototype,” Med. Phys. 43, 4617–4627 (2016)]. While progress updates of this development have been presented at conferences and in journal papers, this paper is the first comprehensive overview of the multisource inverse-geometry CT concept and prototype. The authors also provide a review of all previous IGCT related publications. Methods: Themore » authors designed and implemented a gantry-based 32-source IGCT scanner with 22 cm field-of-view, 16 cm z-coverage, 1 s rotation time, 1.09 × 1.024 mm detector cell size, as low as 0.4 × 0.8 mm focal spot size and 80–140 kVp x-ray source voltage. The system is built using commercially available CT components and a custom made distributed x-ray source. The authors developed dedicated controls, calibrations, and reconstruction algorithms and evaluated the system performance using phantoms and small animals. Results: The authors performed IGCT system experiments and demonstrated tube current up to 125 mA with up to 32 focal spots. The authors measured a spatial resolution of 13 lp/cm at 5% cutoff. The scatter-to-primary ratio is estimated 62% for a 32 cm water phantom at 140 kVp. The authors scanned several phantoms and small animals. The initial images have relatively high noise due to the low x-ray flux levels but minimal artifacts. Conclusions: IGCT has unique benefits in terms of dose-efficiency and cone-beam artifacts, but comes with challenges in terms of scattered radiation and x-ray flux limits. To the authors’ knowledge, their prototype is the first gantry-based IGCT scanner. The authors summarized the design and implementation of the scanner and the authors presented results with phantoms and small animals.« less
Multisource inverse-geometry CT. Part I. System concept and development
De Man, Bruno; Uribe, Jorge; Baek, Jongduk; Harrison, Dan; Yin, Zhye; Longtin, Randy; Roy, Jaydeep; Waters, Bill; Wilson, Colin; Short, Jonathan; Inzinna, Lou; Reynolds, Joseph; Neculaes, V. Bogdan; Frutschy, Kristopher; Senzig, Bob; Pelc, Norbert
2016-01-01
Purpose: This paper presents an overview of multisource inverse-geometry computed tomography (IGCT) as well as the development of a gantry-based research prototype system. The development of the distributed x-ray source is covered in a companion paper [V. B. Neculaes et al., “Multisource inverse-geometry CT. Part II. X-ray source design and prototype,” Med. Phys. 43, 4617–4627 (2016)]. While progress updates of this development have been presented at conferences and in journal papers, this paper is the first comprehensive overview of the multisource inverse-geometry CT concept and prototype. The authors also provide a review of all previous IGCT related publications. Methods: The authors designed and implemented a gantry-based 32-source IGCT scanner with 22 cm field-of-view, 16 cm z-coverage, 1 s rotation time, 1.09 × 1.024 mm detector cell size, as low as 0.4 × 0.8 mm focal spot size and 80–140 kVp x-ray source voltage. The system is built using commercially available CT components and a custom made distributed x-ray source. The authors developed dedicated controls, calibrations, and reconstruction algorithms and evaluated the system performance using phantoms and small animals. Results: The authors performed IGCT system experiments and demonstrated tube current up to 125 mA with up to 32 focal spots. The authors measured a spatial resolution of 13 lp/cm at 5% cutoff. The scatter-to-primary ratio is estimated 62% for a 32 cm water phantom at 140 kVp. The authors scanned several phantoms and small animals. The initial images have relatively high noise due to the low x-ray flux levels but minimal artifacts. Conclusions: IGCT has unique benefits in terms of dose-efficiency and cone-beam artifacts, but comes with challenges in terms of scattered radiation and x-ray flux limits. To the authors’ knowledge, their prototype is the first gantry-based IGCT scanner. The authors summarized the design and implementation of the scanner and the authors presented results with phantoms and small animals. PMID:27487877
Comparison of VRX CT scanners geometries
NASA Astrophysics Data System (ADS)
DiBianca, Frank A.; Melnyk, Roman; Duckworth, Christopher N.; Russ, Stephan; Jordan, Lawrence M.; Laughter, Joseph S.
2001-06-01
A technique called Variable-Resolution X-ray (VRX) detection greatly increases the spatial resolution in computed tomography (CT) and digital radiography (DR) as the field size decreases. The technique is based on a principle called `projective compression' that allows both the resolution element and the sampling distance of a CT detector to scale with the subject or field size. For very large (40 - 50 cm) field sizes, resolution exceeding 2 cy/mm is possible and for very small fields, microscopy is attainable with resolution exceeding 100 cy/mm. This paper compares the benefits obtainable with two different VRX detector geometries: the single-arm geometry and the dual-arm geometry. The analysis is based on Monte Carlo simulations and direct calculations. The results of this study indicate that the dual-arm system appears to have more advantages than the single-arm technique.
Comparison of multi-arm VRX CT scanners through computer models
NASA Astrophysics Data System (ADS)
Rendon, David A.; DiBianca, Frank A.; Keyes, Gary S.
2007-03-01
Variable Resolution X-ray (VRX) CT scanners allow imaging of different sized anatomy at the same level of detail using the same device. This is achieved by tilting the x-ray detectors so that the projected size of the detecting elements is varied producing reconstructions of smaller fields of view with higher spatial resolution.1 The detector can be divided in two or more separate segments, called arms, which can be placed at different angles, allowing some flexibility for the scanner design. In particular, several arms can be set at different angles creating a target region of considerably higher resolution that can be used to track the evolution of a previously diagnosed condition, while keeping the patient completely inside the field of view (FOV).2 This work presents newly-developed computer models of single-slice VRX scanners that allow us to study and compare different configurations (that is, various types of detectors arranged in any number of arms arranged in different geometries) in terms of spatial and contrast resolution. In particular, we are interested in comparing the performance of various geometric configurations that would otherwise be considered equivalent (using the same equipment, imaging FOVs of the same sizes, and having a similar overall scanner size). For this, a VRX simulator was developed, along with mathematical phantoms for spatial resolution and contrast analysis. These tools were used to compare scanner configurations that can be reproduced with materials presently available in our lab.
DiFilippo, Frank P.
2008-01-01
A multi-pinhole collimation device is developed that uses the gamma camera detectors of a clinical SPECT or SPECT-CT scanner to produce high resolution SPECT images. The device consists of a rotating cylindrical collimator having 22 tungsten pinholes with 0.9 mm diameter apertures and an animal bed inside the collimator that moves linearly to provide helical or ordered-subsets axial sampling. CT images also may be acquired on a SPECT-CT scanner for purposes of image co-registration and SPECT attenuation correction. The device is placed on the patient table of the scanner without attaching to the detectors or scanner gantry. The system geometry is calibrated in-place from point source data and is then used during image reconstruction. The SPECT imaging performance of the device is evaluated with test phantom scans. Spatial resolution from reconstructed point source images is measured to be 0.6 mm full width at half maximum or better. Micro-Derenzo phantom images demonstrate the ability to resolve 0.7 mm diameter rod patterns. The axial slabs of a Micro-Defrise phantom are visualized well. Collimator efficiency exceeds 0.05% at the center of the field of view, and images of a uniform phantom show acceptable uniformity and minimal artifact. The overall simplicity and relatively good imaging performance of the device make it an interesting low-cost alternative to dedicated small animal scanners. PMID:18635899
NASA Astrophysics Data System (ADS)
Di Filippo, Frank P.
2008-08-01
A multi-pinhole collimation device is developed that uses the gamma camera detectors of a clinical SPECT or SPECT-CT scanner to produce high-resolution SPECT images. The device consists of a rotating cylindrical collimator having 22 tungsten pinholes with 0.9 mm diameter apertures and an animal bed inside the collimator that moves linearly to provide helical or ordered-subsets axial sampling. CT images also may be acquired on a SPECT-CT scanner for purposes of image co-registration and SPECT attenuation correction. The device is placed on the patient table of the scanner without attaching to the detectors or scanner gantry. The system geometry is calibrated in-place from point source data and is then used during image reconstruction. The SPECT imaging performance of the device is evaluated with test phantom scans. Spatial resolution from reconstructed point source images is measured to be 0.6 mm full width at half maximum or better. Micro-Derenzo phantom images demonstrate the ability to resolve 0.7 mm diameter rod patterns. The axial slabs of a Micro-Defrise phantom are visualized well. Collimator efficiency exceeds 0.05% at the center of the field of view, and images of a uniform phantom show acceptable uniformity and minimal artifact. The overall simplicity and relatively good imaging performance of the device make it an interesting low-cost alternative to dedicated small animal scanners.
High speed imaging of dynamic processes with a switched source x-ray CT system
NASA Astrophysics Data System (ADS)
Thompson, William M.; Lionheart, William R. B.; Morton, Edward J.; Cunningham, Mike; Luggar, Russell D.
2015-05-01
Conventional x-ray computed tomography (CT) scanners are limited in their scanning speed by the mechanical constraints of their rotating gantries and as such do not provide the necessary temporal resolution for imaging of fast-moving dynamic processes, such as moving fluid flows. The Real Time Tomography (RTT) system is a family of fast cone beam CT scanners which instead use multiple fixed discrete sources and complete rings of detectors in an offset geometry. We demonstrate the potential of this system for use in the imaging of such high speed dynamic processes and give results using simulated and real experimental data. The unusual scanning geometry results in some challenges in image reconstruction, which are overcome using algebraic iterative reconstruction techniques and explicit regularisation. Through the use of a simple temporal regularisation term and by optimising the source firing pattern, we show that temporal resolution of the system may be increased at the expense of spatial resolution, which may be advantageous in some situations. Results are given showing temporal resolution of approximately 500 µs with simulated data and 3 ms with real experimental data.
Ahmed, Abdella M; Tashima, Hideaki; Yamaya, Taiga
2018-03-01
The dominant factor limiting the intrinsic spatial resolution of a positron emission tomography (PET) system is the size of the crystal elements in the detector. To increase sensitivity and achieve high spatial resolution, it is essential to use advanced depth-of-interaction (DOI) detectors and arrange them close to the subject. The DOI detectors help maintain high spatial resolution by mitigating the parallax error caused by the thickness of the scintillator near the peripheral regions of the field-of-view. As an optimal geometry for a brain PET scanner, with high sensitivity and spatial resolution, we proposed and developed the helmet-chin PET scanner using 54 four-layered DOI detectors consisting of a 16 × 16 × 4 array of GSOZ scintillator crystals with dimensions of 2.8 × 2.8 × 7.5 mm 3 . All the detectors used in the helmet-chin PET scanner had the same spatial resolution. In this study, we conducted a feasibility study of a new add-on detector arrangement for the helmet PET scanner by replacing the chin detector with a segmented crystal cube, having high spatial resolution in all directions, which can be placed inside the mouth. The crystal cube (which we have named the mouth-insert detector) has an array of 20 × 20 × 20 LYSO crystal segments with dimensions of 1 × 1 × 1 mm 3 . Thus, the scanner is formed by the combination of the helmet and mouth-insert detectors, and is referred to as the helmet-mouth-insert PET scanner. The results show that the helmet-mouth-insert PET scanner has comparable sensitivity and improved spatial resolution near the center of the hemisphere, compared to the helmet-chin PET scanner.
Designing a compact high performance brain PET scanner—simulation study
NASA Astrophysics Data System (ADS)
Gong, Kuang; Majewski, Stan; Kinahan, Paul E.; Harrison, Robert L.; Elston, Brian F.; Manjeshwar, Ravindra; Dolinsky, Sergei; Stolin, Alexander V.; Brefczynski-Lewis, Julie A.; Qi, Jinyi
2016-05-01
The desire to understand normal and disordered human brain function of upright, moving persons in natural environments motivates the development of the ambulatory micro-dose brain PET imager (AMPET). An ideal system would be light weight but with high sensitivity and spatial resolution, although these requirements are often in conflict with each other. One potential approach to meet the design goals is a compact brain-only imaging device with a head-sized aperture. However, a compact geometry increases parallax error in peripheral lines of response, which increases bias and variance in region of interest (ROI) quantification. Therefore, we performed simulation studies to search for the optimal system configuration and to evaluate the potential improvement in quantification performance over existing scanners. We used the Cramér-Rao variance bound to compare the performance for ROI quantification using different scanner geometries. The results show that while a smaller ring diameter can increase photon detection sensitivity and hence reduce the variance at the center of the field of view, it can also result in higher variance in peripheral regions when the length of detector crystal is 15 mm or more. This variance can be substantially reduced by adding depth-of-interaction (DOI) measurement capability to the detector modules. Our simulation study also shows that the relative performance depends on the size of the ROI, and a large ROI favors a compact geometry even without DOI information. Based on these results, we propose a compact ‘helmet’ design using detectors with DOI capability. Monte Carlo simulations show the helmet design can achieve four-fold higher sensitivity and resolve smaller features than existing cylindrical brain PET scanners. The simulations also suggest that improving TOF timing resolution from 400 ps to 200 ps also results in noticeable improvement in image quality, indicating better timing resolution is desirable for brain imaging.
Designing a compact high performance brain PET scanner—simulation study
Gong, Kuang; Majewski, Stan; Kinahan, Paul E; Harrison, Robert L; Elston, Brian F; Manjeshwar, Ravindra; Dolinsky, Sergei; Stolin, Alexander V; Brefczynski-Lewis, Julie A; Qi, Jinyi
2016-01-01
The desire to understand normal and disordered human brain function of upright, moving persons in natural environments motivates the development of the ambulatory micro-dose brain PET imager (AMPET). An ideal system would be light weight but with high sensitivity and spatial resolution, although these requirements are often in conflict with each other. One potential approach to meet the design goals is a compact brain-only imaging device with a head-sized aperture. However, a compact geometry increases parallax error in peripheral lines of response, which increases bias and variance in region of interest (ROI) quantification. Therefore, we performed simulation studies to search for the optimal system configuration and to evaluate the potential improvement in quantification performance over existing scanners. We used the Cramér–Rao variance bound to compare the performance for ROI quantification using different scanner geometries. The results show that while a smaller ring diameter can increase photon detection sensitivity and hence reduce the variance at the center of the field of view, it can also result in higher variance in peripheral regions when the length of detector crystal is 15 mm or more. This variance can be substantially reduced by adding depth-of- interaction (DOI) measurement capability to the detector modules. Our simulation study also shows that the relative performance depends on the size of the ROI, and a large ROI favors a compact geometry even without DOI information. Based on these results, we propose a compact ‘helmet’ design using detectors with DOI capability. Monte Carlo simulations show the helmet design can achieve four-fold higher sensitivity and resolve smaller features than existing cylindrical brain PET scanners. The simulations also suggest that improving TOF timing resolution from 400 ps to 200 ps also results in noticeable improvement in image quality, indicating better timing resolution is desirable for brain imaging. PMID:27081753
Simultaneous two-view epipolar geometry estimation and motion segmentation by 4D tensor voting.
Tong, Wai-Shun; Tang, Chi-Keung; Medioni, Gérard
2004-09-01
We address the problem of simultaneous two-view epipolar geometry estimation and motion segmentation from nonstatic scenes. Given a set of noisy image pairs containing matches of n objects, we propose an unconventional, efficient, and robust method, 4D tensor voting, for estimating the unknown n epipolar geometries, and segmenting the static and motion matching pairs into n independent motions. By considering the 4D isotropic and orthogonal joint image space, only two tensor voting passes are needed, and a very high noise to signal ratio (up to five) can be tolerated. Epipolar geometries corresponding to multiple, rigid motions are extracted in succession. Only two uncalibrated frames are needed, and no simplifying assumption (such as affine camera model or homographic model between images) other than the pin-hole camera model is made. Our novel approach consists of propagating a local geometric smoothness constraint in the 4D joint image space, followed by global consistency enforcement for extracting the fundamental matrices corresponding to independent motions. We have performed extensive experiments to compare our method with some representative algorithms to show that better performance on nonstatic scenes are achieved. Results on challenging data sets are presented.
An Automatic Procedure for Combining Digital Images and Laser Scanner Data
NASA Astrophysics Data System (ADS)
Moussa, W.; Abdel-Wahab, M.; Fritsch, D.
2012-07-01
Besides improving both the geometry and the visual quality of the model, the integration of close-range photogrammetry and terrestrial laser scanning techniques directs at filling gaps in laser scanner point clouds to avoid modeling errors, reconstructing more details in higher resolution and recovering simple structures with less geometric details. Thus, within this paper a flexible approach for the automatic combination of digital images and laser scanner data is presented. Our approach comprises two methods for data fusion. The first method starts by a marker-free registration of digital images based on a point-based environment model (PEM) of a scene which stores the 3D laser scanner point clouds associated with intensity and RGB values. The PEM allows the extraction of accurate control information for the direct computation of absolute camera orientations with redundant information by means of accurate space resection methods. In order to use the computed relations between the digital images and the laser scanner data, an extended Helmert (seven-parameter) transformation is introduced and its parameters are estimated. Precedent to that, in the second method, the local relative orientation parameters of the camera images are calculated by means of an optimized Structure and Motion (SaM) reconstruction method. Then, using the determined transformation parameters results in having absolute oriented images in relation to the laser scanner data. With the resulting absolute orientations we have employed robust dense image reconstruction algorithms to create oriented dense image point clouds, which are automatically combined with the laser scanner data to form a complete detailed representation of a scene. Examples of different data sets are shown and experimental results demonstrate the effectiveness of the presented procedures.
Image reconstruction and system modeling techniques for virtual-pinhole PET insert systems
Keesing, Daniel B; Mathews, Aswin; Komarov, Sergey; Wu, Heyu; Song, Tae Yong; O'Sullivan, Joseph A; Tai, Yuan-Chuan
2012-01-01
Virtual-pinhole PET (VP-PET) imaging is a new technology in which one or more high-resolution detector modules are integrated into a conventional PET scanner with lower-resolution detectors. It can locally enhance the spatial resolution and contrast recovery near the add-on detectors, and depending on the configuration, may also increase the sensitivity of the system. This novel scanner geometry makes the reconstruction problem more challenging compared to the reconstruction of data from a standalone PET scanner, as new techniques are needed to model and account for the non-standard acquisition. In this paper, we present a general framework for fully 3D modeling of an arbitrary VP-PET insert system. The model components are incorporated into a statistical reconstruction algorithm to estimate an image from the multi-resolution data. For validation, we apply the proposed model and reconstruction approach to one of our custom-built VP-PET systems – a half-ring insert device integrated into a clinical PET/CT scanner. Details regarding the most important implementation issues are provided. We show that the proposed data model is consistent with the measured data, and that our approach can lead to reconstructions with improved spatial resolution and lesion detectability. PMID:22490983
Wear Distribution Detection of Knee Joint Prostheses by Means of 3D Optical Scanners
Affatato, Saverio; Valigi, Maria Cristina; Logozzo, Silvia
2017-01-01
The objective of this study was to examine total knee polyethylene inserts from in vitro simulation to evaluate and display—using a 3D optical scanner—wear patterns and wear rates of inserts exposed to wear by means of simulators. Various sets of tibial inserts have been reconstructed by using optical scanners. With this in mind, the wear behavior of fixed and mobile bearing polyethylene knee configurations was investigated using a knee wear joint simulator. After the completion of the wear test, the polyethylene menisci were analyzed by an innovative 3D optical scanners in order to evaluate the 3D wear distribution on the prosthesis surface. This study implemented a new procedure for evaluating polyethylene bearings of joint prostheses obtained after in vitro wear tests and the proposed new approach allowed quantification of the contact zone on the geometry of total knee prostheses. The results of the present study showed that mobile TKPs (total knee prosthesis) have lower wear resistance with respect to fixed TKPs. PMID:28772725
A prototype optical-CT system for PRESAGE 3D dosimeter readout
NASA Astrophysics Data System (ADS)
Miles, Devin; Yoon, Paul; Kodra, Jacob; Adamovics, John; Oldham, Mark
2017-05-01
This work introduces the Duke Integrated-lens Optical Scanner (DIOS), a prototype optical-CT system designed for convenient and low-cost readout of PRESAGE 3D dosimeters. A key novelty of the DIOS is the incorporation of a multi-purpose light-collimating tank (the LC-tank). The LC-tank collimates light from a point source, maintains parallel ray geometry through a dosimeter mounted inside the tank, and refocuses emergent light onto a CCD detector. A second purpose is to dramatically reduce the amount of refractive matched fluid required in prior optical-CT scanners. This is achieved by substituting large quantities of refractive-matched fluid with solid RI-matched polyurethane. The advantages of DIOS include eliminating the need for expensive telecentric lenses, and eliminating the impracticality of large volumes of RI matched fluid. The DIOS is potentially more susceptible to stray-light artifacts. Preliminary phantom testing shows promising agreement between PRESAGE/DIOS readout and prior commissioned optical-CT scanners, as well as with Eclipse dose calculations.
NASA Astrophysics Data System (ADS)
Boisson, F.; Wimberley, C. J.; Lehnert, W.; Zahra, D.; Pham, T.; Perkins, G.; Hamze, H.; Gregoire, M.-C.; Reilhac, A.
2013-10-01
Monte Carlo-based simulation of positron emission tomography (PET) data plays a key role in the design and optimization of data correction and processing methods. Our first aim was to adapt and configure the PET-SORTEO Monte Carlo simulation program for the geometry of the widely distributed Inveon PET preclinical scanner manufactured by Siemens Preclinical Solutions. The validation was carried out against actual measurements performed on the Inveon PET scanner at the Australian Nuclear Science and Technology Organisation in Australia and at the Brain & Mind Research Institute and by strictly following the NEMA NU 4-2008 standard. The comparison of simulated and experimental performance measurements included spatial resolution, sensitivity, scatter fraction and count rates, image quality and Derenzo phantom studies. Results showed that PET-SORTEO reliably reproduces the performances of this Inveon preclinical system. In addition, imaging studies showed that the PET-SORTEO simulation program provides raw data for the Inveon scanner that can be fully corrected and reconstructed using the same programs as for the actual data. All correction techniques (attenuation, scatter, randoms, dead-time, and normalization) can be applied on the simulated data leading to fully quantitative reconstructed images. In the second part of the study, we demonstrated its ability to generate fast and realistic biological studies. PET-SORTEO is a workable and reliable tool that can be used, in a classical way, to validate and/or optimize a single PET data processing step such as a reconstruction method. However, we demonstrated that by combining a realistic simulated biological study ([11C]Raclopride here) involving different condition groups, simulation allows one also to assess and optimize the data correction, reconstruction and data processing line flow as a whole, specifically for each biological study, which is our ultimate intent.
Sensitivity and daily quality control of a mobile PET/CT scanner operating in 3-dimensional mode.
Belakhlef, Abdelfatihe; Church, Clifford; Fraser, Ron; Lakhanpal, Suresh
2007-12-01
This study investigated the stability of the sensitivity of a mobile PET/CT scanner and tested a phantom experiment to improve on the daily quality control recommendations of the manufacturer. Unlike in-house scanners, mobile PET/CT devices are subjected to a harsher, continuously changing environment that can alter their performance. The parameter of sensitivity was investigated because it reflects directly on standardized uptake value, a key factor in cancer evaluation. A (68)Ge phantom of known activity concentration was scanned 6 times a month for 11 consecutive months using a mobile PET/CT scanner that operates in 3-dimensional mode only. The scans were acquired as 2 contiguous bed positions, with raw data obtained and reconstructed using parameters identical to those used for oncology patients, including CT-extracted attenuation coefficients and decay, scatter, geometry, and randoms corrections. After visual inspection of all reconstructed images, identical regions of interest were drawn on each image to obtain the activity concentration of individual slices. The original activity concentration was then decay-corrected to the scanning day, and the percentage sensitivity of the slice was calculated and graphed. The daily average sensitivity of the scanner, over 11 consecutive months, was also obtained and used to evaluate the stability of sensitivity. Our particular scanner showed a daily average sensitivity ranging from -8.6% to 6.5% except for one instance, when the sensitivity dropped by an unacceptable degree, 34.8%. Our 11-mo follow-up of a mobile PET/CT scanner demonstrated that its sensitivity remained within acceptable clinical limits except for one instance, when the scanner had to be serviced before patients could be imaged. To enhance our confidence in the uniformity of sensitivity across slices, we added a phantom scan to the daily quality control recommendations of the manufacturer.
Three-Dimensional Weighting in Cone Beam FBP Reconstruction and Its Transformation Over Geometries.
Tang, Shaojie; Huang, Kuidong; Cheng, Yunyong; Niu, Tianye; Tang, Xiangyang
2018-06-01
With substantially increased number of detector rows in multidetector CT (MDCT), axial scan with projection data acquired along a circular source trajectory has become the method-of-choice in increasing clinical applications. Recognizing the practical relevance of image reconstruction directly from the projection data acquired in the native cone beam (CB) geometry, especially in scenarios wherein the most achievable in-plane resolution is desirable, we present a three-dimensional (3-D) weighted CB-FBP algorithm in such geometry in this paper. We start the algorithm's derivation in the cone-parallel geometry. Via changing of variables, taking the Jacobian into account and making heuristic and empirical assumptions, we arrive at the formulas for 3-D weighted image reconstruction in the native CB geometry. Using the projection data simulated by computer and acquired by an MDCT scanner, we evaluate and verify performance of the proposed algorithm for image reconstruction directly from projection data acquired in the native CB geometry. The preliminary data show that the proposed algorithm performs as well as the 3-D weighted CB-FBP algorithm in the cone-parallel geometry. The proposed algorithm is anticipated to find its utility in extensive clinical and preclinical applications wherein the reconstruction of images in the native CB geometry, i.e., the geometry for data acquisition, is of relevance.
Geometric aspects in digital analysis of Multi-Spectral Scanner (MSS) data
NASA Technical Reports Server (NTRS)
Mikhail, E. M.; Baker, J. R.
1973-01-01
Present automated systems of interpretation which apply pattern recognition techniques on MSS data do not fully consider the geometry of the acquisition system. In an effort to improve the usefulness of the MSS data when digitally treated, geometric aspects are analyzed and discussed. Attempts to correct for scanner instabilities in position and orientation by affine and polynomial transformations, as well as by modified collinearity equations are described. Methods of accounting for panoramic and relief effects are also discussed. It is anticipated that reliable area as well as position determinations can be accomplished during the process of automatic interpretation. A concept for a unified approach to the treatment of remote sensing data, both metric and nonmetric is presented.
Four-arm variable-resolution x-ray detector for CT target imaging
NASA Astrophysics Data System (ADS)
DiBianca, Frank A.; Gulabani, Daya; Jordan, Lawrence M.; Vangala, Sravanthi; Rendon, David; Laughter, Joseph S.; Melnyk, Roman; Gaber, M. W.; Keyes, Gary S.
2005-04-01
The basic VRX technique boosts spatial resolution of a CT scanner in the scan plane by two or more orders of magnitude by reducing the angle of incidence of the x-ray beam with respect to the detector surface. A four-arm Variable-Resolution X-ray (VRX) detector has been developed for CT scanning. The detector allows for "target imaging" in which an area of interest is scanned at higher resolution than the remainder of the subject, yielding even higher resolution for the focal area than that obtained from the basic VRX technique. The new VRX-CT detector comprises four quasi-identical arms each containing six 24-cell modules (576 cells total). The modules are made of individual custom CdWO4 scintillators optically-coupled to custom photodiode arrays. The maximum scan field is 40 cm for a magnification of 1.4. A significant advantage of the four-arm geometry is that it can transform quickly to the two-arm, or even the single-arm geometry, for comparison studies. These simpler geometries have already been shown experimentally to yield in-plane CT detector resolution exceeding 60 cy/mm (<8μ) for small fields of view. Geometrical size and resolution limits of the target VRX field are calculated. Two-arm VRX-CT data are used to simulate and establish the feasibility of VRX CT target imaging. A prototype target VRX-CT scanner has been built and is undergoing initial testing.
Lesion insertion in the projection domain: Methods and initial results
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chen, Baiyu; Leng, Shuai; Yu, Lifeng
2015-12-15
Purpose: To perform task-based image quality assessment in CT, it is desirable to have a large number of realistic patient images with known diagnostic truth. One effective way of achieving this objective is to create hybrid images that combine patient images with inserted lesions. Because conventional hybrid images generated in the image domain fails to reflect the impact of scan and reconstruction parameters on lesion appearance, this study explored a projection-domain approach. Methods: Lesions were segmented from patient images and forward projected to acquire lesion projections. The forward-projection geometry was designed according to a commercial CT scanner and accommodated bothmore » axial and helical modes with various focal spot movement patterns. The energy employed by the commercial CT scanner for beam hardening correction was measured and used for the forward projection. The lesion projections were inserted into patient projections decoded from commercial CT projection data. The combined projections were formatted to match those of commercial CT raw data, loaded onto a commercial CT scanner, and reconstructed to create the hybrid images. Two validations were performed. First, to validate the accuracy of the forward-projection geometry, images were reconstructed from the forward projections of a virtual ACR phantom and compared to physically acquired ACR phantom images in terms of CT number accuracy and high-contrast resolution. Second, to validate the realism of the lesion in hybrid images, liver lesions were segmented from patient images and inserted back into the same patients, each at a new location specified by a radiologist. The inserted lesions were compared to the original lesions and visually assessed for realism by two experienced radiologists in a blinded fashion. Results: For the validation of the forward-projection geometry, the images reconstructed from the forward projections of the virtual ACR phantom were consistent with the images physically acquired for the ACR phantom in terms of Hounsfield unit and high-contrast resolution. For the validation of the lesion realism, lesions of various types were successfully inserted, including well circumscribed and invasive lesions, homogeneous and heterogeneous lesions, high-contrast and low-contrast lesions, isolated and vessel-attached lesions, and small and large lesions. The two experienced radiologists who reviewed the original and inserted lesions could not identify the lesions that were inserted. The same lesion, when inserted into the projection domain and reconstructed with different parameters, demonstrated a parameter-dependent appearance. Conclusions: A framework has been developed for projection-domain insertion of lesions into commercial CT images, which can be potentially expanded to all geometries of CT scanners. Compared to conventional image-domain methods, the authors’ method reflected the impact of scan and reconstruction parameters on lesion appearance. Compared to prior projection-domain methods, the authors’ method has the potential to achieve higher anatomical complexity by employing clinical patient projections and real patient lesions.« less
Lesion insertion in the projection domain: Methods and initial results
Chen, Baiyu; Leng, Shuai; Yu, Lifeng; Yu, Zhicong; Ma, Chi; McCollough, Cynthia
2015-01-01
Purpose: To perform task-based image quality assessment in CT, it is desirable to have a large number of realistic patient images with known diagnostic truth. One effective way of achieving this objective is to create hybrid images that combine patient images with inserted lesions. Because conventional hybrid images generated in the image domain fails to reflect the impact of scan and reconstruction parameters on lesion appearance, this study explored a projection-domain approach. Methods: Lesions were segmented from patient images and forward projected to acquire lesion projections. The forward-projection geometry was designed according to a commercial CT scanner and accommodated both axial and helical modes with various focal spot movement patterns. The energy employed by the commercial CT scanner for beam hardening correction was measured and used for the forward projection. The lesion projections were inserted into patient projections decoded from commercial CT projection data. The combined projections were formatted to match those of commercial CT raw data, loaded onto a commercial CT scanner, and reconstructed to create the hybrid images. Two validations were performed. First, to validate the accuracy of the forward-projection geometry, images were reconstructed from the forward projections of a virtual ACR phantom and compared to physically acquired ACR phantom images in terms of CT number accuracy and high-contrast resolution. Second, to validate the realism of the lesion in hybrid images, liver lesions were segmented from patient images and inserted back into the same patients, each at a new location specified by a radiologist. The inserted lesions were compared to the original lesions and visually assessed for realism by two experienced radiologists in a blinded fashion. Results: For the validation of the forward-projection geometry, the images reconstructed from the forward projections of the virtual ACR phantom were consistent with the images physically acquired for the ACR phantom in terms of Hounsfield unit and high-contrast resolution. For the validation of the lesion realism, lesions of various types were successfully inserted, including well circumscribed and invasive lesions, homogeneous and heterogeneous lesions, high-contrast and low-contrast lesions, isolated and vessel-attached lesions, and small and large lesions. The two experienced radiologists who reviewed the original and inserted lesions could not identify the lesions that were inserted. The same lesion, when inserted into the projection domain and reconstructed with different parameters, demonstrated a parameter-dependent appearance. Conclusions: A framework has been developed for projection-domain insertion of lesions into commercial CT images, which can be potentially expanded to all geometries of CT scanners. Compared to conventional image-domain methods, the authors’ method reflected the impact of scan and reconstruction parameters on lesion appearance. Compared to prior projection-domain methods, the authors’ method has the potential to achieve higher anatomical complexity by employing clinical patient projections and real patient lesions. PMID:26632058
Direct determination of geometric alignment parameters for cone-beam scanners
Mennessier, C; Clackdoyle, R; Noo, F
2009-01-01
This paper describes a comprehensive method for determining the geometric alignment parameters for cone-beam scanners (often called calibrating the scanners or performing geometric calibration). The method is applicable to x-ray scanners using area detectors, or to SPECT systems using pinholes or cone-beam converging collimators. Images of an alignment test object (calibration phantom) fixed in the field of view of the scanner are processed to determine the nine geometric parameters for each view. The parameter values are found directly using formulae applied to the projected positions of the test object marker points onto the detector. Each view is treated independently, and no restrictions are made on the position of the cone vertex, or on the position or orientation of the detector. The proposed test object consists of 14 small point-like objects arranged with four points on each of three orthogonal lines, and two points on a diagonal line. This test object is shown to provide unique solutions for all possible scanner geometries, even when partial measurement information is lost by points superimposing in the calibration scan. For the many situations where the cone vertex stays reasonably close to a central plane (for circular, planar, or near-planar trajectories), a simpler version of the test object is appropriate. The simpler object consists of six points, two per orthogonal line, but with some restrictions on the positioning of the test object. This paper focuses on the principles and mathematical justifications for the method. Numerical simulations of the calibration process and reconstructions using estimated parameters are also presented to validate the method and to provide evidence of the robustness of the technique. PMID:19242049
Sandell, A; Ohlsson, T; Erlandsson, K; Hellborg, R; Strand, S E
1992-01-01
We have developed a comparatively inexpensive PET system, based on a rotating scanner with two scintillation camera heads, and a nearby low energy electrostatic proton accelerator for production of short-lived radionuclides. Using a 6 MeV proton beam of 5 microA, and by optimization of the target geometry for the 18O(p,n)18F reaction, 750 MBq of 2-18FDG can be obtained. The PET scanner shows a spatial resolution of 6 mm (FWHM) and a sensitivity of 80 s-1kBq-1ml-1 (3 kcps/microCi/ml). Various corrections are included in the imaging process, to compensate for spatial and temporal response variations in the detector system. Both filtered backprojection and iterative reconstruction methods are employed. Clinical studies have been performed with acquisition times of 30-40 min. The system will be used for clinical experimental research with short- as well as long-lived positron emitters. Also the possibility of true 3D reconstruction is under evaluation.
NASA Astrophysics Data System (ADS)
Hafiz Burhan, Mohd; Nor, Nik Hisyamudin Muhd; Yarwindran, Mogan; Ibrahim, Mustaffa; Fahrul Hassan, Mohd; Azwir Azlan, Mohd; Turan, Faiz Mohd; Johan, Kartina
2017-08-01
Healthcare and medical is one of the most expensive field in the modern world. In order to fulfil medical requirement, this study aimed to design an orthotic insole by using Kinect Xbox Gaming Sensor Scanner and CAE softwares. The accuracy of the Kinect® XBOX 360 gaming sensor is capable of producing 3D reconstructed geometry with the maximum and minimum error of 3.78% (2.78mm) and 1.74% (0.46mm) respectively. The orthotic insole design process had been done by using Autodesk Meshmixer 2.6 and Solidworks 2014 software. Functionality of the orthotic insole designed was capable of reducing foot pressure especially in the metatarsal area. Overall, the proposed method was proved to be highly potential in the design of the insole where it promises low cost, less time consuming, and efficiency in regards that the Kinect® XBOX 360 device promised low price compared to other digital 3D scanner since the software needed to run the device can be downloaded for free.
Flow in Coal Seams: An Unconventional Challenge
NASA Astrophysics Data System (ADS)
Armstrong, R. T.; Mostaghimi, P.; Jing, Y.; Gerami, A.
2016-12-01
A significant unconventional resource for energy is the methane gas stored in shallow coal beds, known as coal seam gas. An integrated imaging and modelling framework is developed for analysing petrophysical behaviour of coals. X-ray micro-computed tomography (micro-CT) is applied using a novel contrast agent method for visualising micrometer-sized fractures in coal. The technique allows for the visualisation of coal features not visible with conventional imaging methods. A Late Permian medium volatile bituminous coal from Moura Coal Mine (Queensland, Australia) is imaged and the resulting three-dimensional coal fracture system is extracted for fluid flow simulations. The results demonstrate a direct relationship between coal lithotype and permeability. Scanning electron microscope and energy dispersive spectrometry (SEM-EDS) together with X-ray diffraction (XRD) methods are used for identifying mineral matters at high resolution. SEM high-resolution images are also used to calibrate the micro-CT images and measure the exact aperture size of fractures. This leads to a more accurate estimation of permeability using micro-CT images. To study the significance of geometry and topology of the fracture system, a fracture reconstruction method based on statistical properties of coal is also developed. The network properties including the frequency, aperture size distribution, length, and spacing of the imaged coal fracture system. This allows for a sensitivity analysis on the effects that coal fracture topology and geometry has on coal petrophysical properties. Furthermore, we generate microfluidic chips based on coal fracture observations. The chip is used for flow experiments to visualise multi-fluid processes and measure recovery of gas. A combined numerical and experimental approach is applied to obtain relative permeability curves for different regions of interest. A number of challenges associated with coal samples are discussed and insights are provided for better understanding of these complex porous media systems.
NASA Technical Reports Server (NTRS)
Liu, Tianshu; Kuykendoll, K.; Rhew, R.; Jones, S.
2004-01-01
This paper describes the avian wing geometry (Seagull, Merganser, Teal and Owl) extracted from non-contact surface measurements using a three-dimensional laser scanner. The geometric quantities, including the camber line and thickness distribution of airfoil, wing planform, chord distribution, and twist distribution, are given in convenient analytical expressions. Thus, the avian wing surfaces can be generated and the wing kinematics can be simulated. The aerodynamic characteristics of avian airfoils in steady inviscid flows are briefly discussed. The avian wing kinematics is recovered from videos of three level-flying birds (Crane, Seagull and Goose) based on a two-jointed arm model. A flapping seagull wing in the 3D physical space is re-constructed from the extracted wing geometry and kinematics.
The Theory of Unconventional Warfare: Win, Lose, and Draw
2008-12-01
UNCONVENTIONAL WARFARE MODEL ...................................12 1. Planning Phase...Superiority over Time........................................................................11 Figure 3. Unconventional Warfare Model ...superiority through the six principles of UW illustrated below in the UW model . . B. THE UNCONVENTIONAL WARFARE MODEL Figure 3. Unconventional
Reusable High Aspect Ratio 3-D Nickel Shadow Mask
Shandhi, M.M.H.; Leber, M.; Hogan, A.; Warren, D.J.; Bhandari, R.; Negi, S.
2017-01-01
Shadow Mask technology has been used over the years for resistless patterning and to pattern on unconventional surfaces, fragile substrate and biomaterial. In this work, we are presenting a novel method to fabricate high aspect ratio (15:1) three-dimensional (3D) Nickel (Ni) shadow mask with vertical pattern length and width of 1.2 mm and 40 μm respectively. The Ni shadow mask is 1.5 mm tall and 100 μm wide at the base. The aspect ratio of the shadow mask is 15. Ni shadow mask is mechanically robust and hence easy to handle. It is also reusable and used to pattern the sidewalls of unconventional and complex 3D geometries such as microneedles or neural electrodes (such as the Utah array). The standard Utah array has 100 active sites at the tip of the shaft. Using the proposed high aspect ratio Ni shadow mask, the Utah array can accommodate 300 active sites, 200 of which will be along and around the shaft. The robust Ni shadow mask is fabricated using laser patterning and electroplating techniques. The use of Ni 3D shadow mask will lower the fabrication cost, complexity and time for patterning out-of-plane structures. PMID:29056835
Controllable Edge Feature Sharpening for Dental Applications
2014-01-01
This paper presents a new approach to sharpen blurred edge features in scanned tooth preparation surfaces generated by structured-light scanners. It aims to efficiently enhance the edge features so that the embedded feature lines can be easily identified in dental CAD systems, and to avoid unnatural oversharpening geometry. We first separate the feature regions using graph-cut segmentation, which does not require a user-defined threshold. Then, we filter the face normal vectors to propagate the geometry from the smooth region to the feature region. In order to control the degree of the sharpness, we propose a feature distance measure which is based on normal tensor voting. Finally, the vertex positions are updated according to the modified face normal vectors. We have applied the approach to scanned tooth preparation models. The results show that the blurred edge features are enhanced without unnatural oversharpening geometry. PMID:24741376
Controllable edge feature sharpening for dental applications.
Fan, Ran; Jin, Xiaogang
2014-01-01
This paper presents a new approach to sharpen blurred edge features in scanned tooth preparation surfaces generated by structured-light scanners. It aims to efficiently enhance the edge features so that the embedded feature lines can be easily identified in dental CAD systems, and to avoid unnatural oversharpening geometry. We first separate the feature regions using graph-cut segmentation, which does not require a user-defined threshold. Then, we filter the face normal vectors to propagate the geometry from the smooth region to the feature region. In order to control the degree of the sharpness, we propose a feature distance measure which is based on normal tensor voting. Finally, the vertex positions are updated according to the modified face normal vectors. We have applied the approach to scanned tooth preparation models. The results show that the blurred edge features are enhanced without unnatural oversharpening geometry.
Generation of a Combined Dataset of Simulated Radar and Electro-Optical Imagery
2005-10-05
directional reflectance distribution function (BRDF) predictions and the geometry of a line scanner. Using programs such as MODTRAN and FASCODE, images can be...DIRSIG tries to accurately model scenes through various approaches that model real- world occurrences. MODTRAN is an atmospheric radiative transfer code...used to predict path transmissions and radiances within the atmosphere (DIRSIG Manual, 2004). FASCODE is similar to MODTRAN , however it works as a
Geometry and surface damage in micro electrical discharge machining of micro-holes
NASA Astrophysics Data System (ADS)
Ekmekci, Bülent; Sayar, Atakan; Tecelli Öpöz, Tahsin; Erden, Abdulkadir
2009-10-01
Geometry and subsurface damage of blind micro-holes produced by micro electrical discharge machining (micro-EDM) is investigated experimentally to explore the relational dependence with respect to pulse energy. For this purpose, micro-holes are machined with various pulse energies on plastic mold steel samples using a tungsten carbide tool electrode and a hydrocarbon-based dielectric liquid. Variations in the micro-hole geometry, micro-hole depth and over-cut in micro-hole diameter are measured. Then, unconventional etching agents are applied on the cross sections to examine micro structural alterations within the substrate. It is observed that the heat-damaged segment is composed of three distinctive layers, which have relatively high thicknesses and vary noticeably with respect to the drilling depth. Crack formation is identified on some sections of the micro-holes even by utilizing low pulse energies during machining. It is concluded that the cracking mechanism is different from cracks encountered on the surfaces when machining is performed by using the conventional EDM process. Moreover, an electrically conductive bridge between work material and debris particles is possible at the end tip during machining which leads to electric discharges between the piled segments of debris particles and the tool electrode during discharging.
NASA Astrophysics Data System (ADS)
Thi Phan, Anh Thu; Takahashi, Kazuyoshi; Rikimaru, Atsushi; Higuchi, Yasuhiro
2016-10-01
A method for estimating the height of rice plants, using three-dimensional laser range data from point clouds, is proposed and assessed. Rice plant height (H) is estimated using a reference position at the top of the rice plant, avoiding the need to determine the ground position. Field experiments were performed with a SICK LMS 200 laser scanner in 2013 and 2014 on a test field with five different planting geometries. Percentile analysis identified the closest percentile to the top of the rice plant (pt=1), with vertical distances at the first percentile unaffected by planting geometry. The plant bottom position was identified using three different percentile ranks (pb=95, pb =80, and pb =70). Relative vertical distances (rD) were computed from the difference between the top and bottom positions of the rice plant. These correlated well with measured H, with slopes greater than 1.0. A greater number of stems in 2014 led to steeper slopes. Estimated H was more accurate when plant bottom positions were closer to the ground surface, and the best results were obtained with pb=95 (r2>0.87 RMSE≈4 cm). Overall, H was typically 16.0 cm greater than rD with pb=95.
Choice of unconventional treatment by patients with cancer.
Kimby, Charlotte Kira; Launsø, Laila; Henningsen, Inge; Langgaard, Henrik
2003-08-01
Previous studies conducted on the use of unconventional treatment by patients with cancer have focused on unconventional treatment as a joint group of therapies. The objective of this study is to gather preliminary information about the use of different modes of unconventional cancer treatment by patients with cancer and to describe user profiles of standardized and individualized treatments. Data originate from an ongoing explorative 5-year study of 441 consecutively registered cancer patients who have consulted medical doctors and alternative therapists practicing unconventional treatment in Denmark. This paper is based on data from the first and second of six questionnaires. The unconventional treatments included in this study are categorized into two forms of treatment: standardized and individualized treatment. Four hundred and forty-one (441) Danish patients with cancer who use unconventional cancer treatment. The analysis shows significant correlations between type of treatment and the following variables: gender, education, occupational status, type of cancer, purpose of seeking unconventional treatment, metastatic spread, opinion regarding appropriate unconventional treatment, and simultaneous use of unconventional treatment. The study shows that there are significant differences between patients with cancer choosing standardized and those choosing individualized unconventional treatment. The probability of choosing standardized unconventional treatment is greatest among male participants, patients having shorter school education, and for patients who have recovery as the goal of seeking unconventional treatment. The probability of choosing individualized unconventional treatment is greatest among women, for patients with longer school education, and for patients wanting relief from symptoms, information, and improvement of general condition as the purpose of seeking unconventional cancer treatment. Patients with breast and gynecologic cancer are more inclined to seek individualized treatment than patients with all other cancer diseases. The study points to the fact that it might be essential to differentiate between different forms of unconventional treatment to understand the use by patients with cancer and the outcomes of these treatments.
Purchasing unconventional fuels
DOE Office of Scientific and Technical Information (OSTI.GOV)
Doyal, J.
1995-09-01
The reasons to seek unconventional fuels are to either insure a fuel supply or to reduce existing fuel costs. The keys to successfully utilizing unconventional fuel are: (1) build as much flexibility as possible in the variety, quality, quantity and deliverability of the unconventional fuel sources that you can utilize; (2) provide maximum pricing flexibility; (3) fully commit to work with unconventional fuel suppliers; and to (4) consider unconventional fuel operations as a market opportunity. Unconventional fuels operations are well suited to marginal existing operations and can also supplement new startups with uncertain fuel supplies. Unconventional fuel operations can alsomore » help existing facilities generate above market profits for those willing to accommodate the wide market swings inherent in this fledgling industry.« less
Pan, Xiaochuan; Sidky, Emil Y; Vannier, Michael
2010-01-01
Despite major advances in x-ray sources, detector arrays, gantry mechanical design and especially computer performance, one component of computed tomography (CT) scanners has remained virtually constant for the past 25 years—the reconstruction algorithm. Fundamental advances have been made in the solution of inverse problems, especially tomographic reconstruction, but these works have not been translated into clinical and related practice. The reasons are not obvious and seldom discussed. This review seeks to examine the reasons for this discrepancy and provides recommendations on how it can be resolved. We take the example of field of compressive sensing (CS), summarizing this new area of research from the eyes of practical medical physicists and explaining the disconnection between theoretical and application-oriented research. Using a few issues specific to CT, which engineers have addressed in very specific ways, we try to distill the mathematical problem underlying each of these issues with the hope of demonstrating that there are interesting mathematical problems of general importance that can result from in depth analysis of specific issues. We then sketch some unconventional CT-imaging designs that have the potential to impact on CT applications, if the link between applied mathematicians and engineers/physicists were stronger. Finally, we close with some observations on how the link could be strengthened. There is, we believe, an important opportunity to rapidly improve the performance of CT and related tomographic imaging techniques by addressing these issues. PMID:20376330
NASA Astrophysics Data System (ADS)
Pan, Xiaochuan; Sidky, Emil Y.; Vannier, Michael
2009-12-01
Despite major advances in x-ray sources, detector arrays, gantry mechanical design and especially computer performance, one component of computed tomography (CT) scanners has remained virtually constant for the past 25 years—the reconstruction algorithm. Fundamental advances have been made in the solution of inverse problems, especially tomographic reconstruction, but these works have not been translated into clinical and related practice. The reasons are not obvious and seldom discussed. This review seeks to examine the reasons for this discrepancy and provides recommendations on how it can be resolved. We take the example of field of compressive sensing (CS), summarizing this new area of research from the eyes of practical medical physicists and explaining the disconnection between theoretical and application-oriented research. Using a few issues specific to CT, which engineers have addressed in very specific ways, we try to distill the mathematical problem underlying each of these issues with the hope of demonstrating that there are interesting mathematical problems of general importance that can result from in depth analysis of specific issues. We then sketch some unconventional CT-imaging designs that have the potential to impact on CT applications, if the link between applied mathematicians and engineers/physicists were stronger. Finally, we close with some observations on how the link could be strengthened. There is, we believe, an important opportunity to rapidly improve the performance of CT and related tomographic imaging techniques by addressing these issues.
Infrared line scanner that digitally corrects for bow-tie distortions
NASA Astrophysics Data System (ADS)
Silva, Raymond J.; Shaw, William; Nordhaus, Kurt
1996-06-01
This paper describes the infrared line scanner (IRLS) developed by Loral Infrared & Imaging Systems for the Advanced Tactical Air Reconnaissance System (ATARS). Features include very wide fields of view, up to 140 degrees in wide mode; high resolution in the 8 - 14 micrometer band; and the ability to collect contiguous ground imagery at velocity to height (V/H) ratios of up to 5 rad per second. In real terms, a V/H ratio of five equates to an aircraft altitude of 200 feet at speeds approaching Mach 1. The ATARS IRLS is an evolution of the AN/AAD-5 and D-500 line scanners that provides several key improvements over its predecessors. Imagery is exported in digital format allowing for real time imagery exploitation. Additionally, by using some novel system approaches that combined the elements of receiver optics, detector geometry, and electronic signal processing, output data rates were held at tolerable levels. The combination of these techniques results in a system that is optimized for best ground area coverage with a minimum number of detector channels. As a consequence the bow-tie effect at the edges of the field of view has been virtually eliminated while simultaneously reducing data storage requirements.
A noble refractive optical scanner with linear response
NASA Astrophysics Data System (ADS)
Mega, Yair J.; Lai, Zhenhua; DiMarzio, Charles A.
2013-03-01
Many applications in various fields of science and engineering use steered optical beam systems. Currently, many methods utilize mirrors in order to steer the beam. However, this approach is an off-axis solution, which normally increases the total size of the system as well as its error and complexity. Other methods use a "Risely Prisms" based solution, which is on-axis solution, however it poses some difficulties from an engineering standpoint, and therefore isn't widely used. We present here a novel technique for steering a beam on its optical axis with a linear deflection response. We derived the formulation for the profile required of the refractive optical component necessary for preforming the beam steering. The functionality of the device was simulated analytically using Matlab, as well as using a ray-tracing software, Zemax, and showed agreement with the analytical model. An optical element was manufactured based on the proposed design and the device was tested. The results show agreement with our hypothesis. We also present some proposed geometries of the several other devices, all based on the same concept, which can be used for higher performance applications such as two-dimensional scanner, video rate scanner etc.
Laser microbeam CT scanning of dosimetry gels
NASA Astrophysics Data System (ADS)
Maryanski, Marek J.; Ranade, Manisha K.
2001-06-01
A novel design of an optical tomographic scanner is described that can be used for 3D mapping of optical attenuation coefficient within translucent cylindrical objects with spatial resolution on the order of 100 microns. Our scanner design utilizes the cylindrical geometry of the imaged object to obtain the desired paths of the scanning light rays. A rotating mirror and a photodetector are placed at two opposite foci of the translucent cylinder that acts as a cylindrical lens. A He-Ne laser beam passes first through a focusing lens and then is reflected by the rotating mirror, so as to scan the interior of the cylinder with focused and parallel paraxial rays that are subsequently collected by the photodetector to produce the projection data, as the cylinder rotates in small angle increments between projections. Filtered backprojection is then used to reconstruct planar distributions of optical attenuation coefficient in the cylinder. Multiplanar scans are used to obtain a complete 3D tomographic reconstruction. Among other applications, the scanner can be used in radiation therapy dosimetry and quality assurance for mapping 3D radiation dose distributions in various types of tissue-equivalent gel phantoms that change their optical attenuation coefficients in proportion to the absorbed radiation dose.
X-ray microtomography-based measurements of meniscal allografts.
Mickiewicz, P; Binkowski, M; Bursig, H; Wróbel, Z
2015-05-01
X-ray microcomputed tomography (XMT) is a technique widely used to image hard and soft tissues. Meniscal allografts as collagen structures can be imaged and analyzed using XMT. The aim of this study was to present an XMT scanning protocol that can be used to obtain the 3D geometry of menisci. It was further applied to compare two methods of meniscal allograft measurement: traditional (based on manual measurement) and novel (based on digital measurement of 3D models of menisci obtained with use of XMT scanner). The XMT-based menisci measurement is a reliable method for assessing the geometry of a meniscal allograft by measuring the basic meniscal dimensions known from traditional protocol. Thirteen dissected menisci were measured according the same principles traditionally applied in a tissue bank. Next, the same specimens were scanned by a laboratory scanner in the XMT Lab. The images were processed to obtain a 3D mesh. 3D models of allograft geometry were then measured using a novel protocol enhanced by computer software. Then, both measurements were compared using statistical tests. The results showed significant differences (P<0.05) between the lengths of the medial and lateral menisci measured in the tissue bank and the XMT Lab. Also, medial meniscal widths were significantly different (P<0.05). Differences in meniscal lengths may result from difficulties in dissected meniscus measurements in tissue banks, and may be related to the elastic structure of the dissected meniscus. Errors may also be caused by the lack of highlighted landmarks on the meniscal surface in this study. The XMT may be a good technique for assessing meniscal dimensions without actually touching the specimen. Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Influences of 3D PET scanner components on increased scatter evaluated by a Monte Carlo simulation
NASA Astrophysics Data System (ADS)
Hirano, Yoshiyuki; Koshino, Kazuhiro; Iida, Hidehiro
2017-05-01
Monte Carlo simulation is widely applied to evaluate the performance of three-dimensional positron emission tomography (3D-PET). For accurate scatter simulations, all components that generate scatter need to be taken into account. The aim of this work was to identify the components that influence scatter. The simulated geometries of a PET scanner were: a precisely reproduced configuration including all of the components; a configuration with the bed, the tunnel and shields; a configuration with the bed and shields; and the simplest geometry with only the bed. We measured and simulated the scatter fraction using two different set-ups: (1) as prescribed by NEMA-NU 2007 and (2) a similar set-up but with a shorter line source, so that all activity was contained only inside the field-of-view (FOV), in order to reduce influences of components outside the FOV. The scatter fractions for the two experimental set-ups were, respectively, 45% and 38%. Regarding the geometrical configurations, the former two configurations gave simulation results in good agreement with the experimental results, but simulation results of the simplest geometry were significantly different at the edge of the FOV. From the simulation of the precise configuration, the object (scatter phantom) was the source of more than 90% of the scatter. This was also confirmed by visualization of photon trajectories. Then, the bed and the tunnel were mainly the sources of the rest of the scatter. From the simulation results, we concluded that the precise construction was not needed; the shields, the tunnel, the bed and the object were sufficient for accurate scatter simulations.
Unconventional medicine in dermatology outpatients in Turkey.
Gönül, Müzeyyen; Gül, Ulker; Cakmak, Seray Külcü; Kiliç, Selim
2009-06-01
Many people use unconventional therapies for health problems, but the extent and pattern of this use in dermatology have not been studied in detail. This article reports the first investigation on the use of unconventional therapies in dermatology in Turkey. To determine the prevalence and characteristics of unconventional therapies used by dermatology outpatients in Turkey. A questionnaire was employed to determine the use of unconventional therapies in patients attending a dermatology clinic in Ankara, Turkey. The patients were questioned about the number of attendances at dermatology clinics, whether they had ever used unconventional therapies and/or drugs without the suggestion of a medical doctor for the current dermatologic disorder, and the forms of unconventional therapies employed. The data were compared statistically with the age, sex, and education status of the patients. The respondents included 443 men and 563 women, with a total of 1006 patients. The mean age of the patients was 36.62 +/- 17.55 years. Of the 1006 patients, 337 (33.5%) had used at least one form of unconventional therapy. The most common diagnoses of the patients using unconventional therapy were acne, psoriasis, contact dermatitis, and fungal infections. The most frequent forms of unconventional therapy used by the patients were humectants, cologne, spiritual healing, and herbs. Unconventional therapy use according to the sex, age, and education status of the patients did not show any significant difference. A significant relationship was found between some forms of unconventional therapy and some skin disorders, including: generalized pruritus and application of cologne; warts and spiritual healing; fungal infections and application of henna; psoriasis and herbal therapy or spiritual healing; alopecia areata and application of garlic; acne and application of lemon juice, clay, or cosmetics. Regardless of patient age, sex, and education status, dermatology outpatients use unconventional therapies for their health. Dermatologists should be aware of the tendency of patients to use unconventional therapies and should guide patients towards the use of harmless treatments.
77 FR 10485 - Unconventional Resources Technology Advisory Committee
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Laser Scanner For Automatic Inspection Of Printed Wiring Boards
NASA Astrophysics Data System (ADS)
Geise, Philip; George, Eugene; Freese, Fritz; Brown, Robert; Ruwe, Victor
1980-11-01
An, Instrument is described which inspects unpopulated, populated (components onserted and leads clinched), and soldered printed wiring boards for correct hole location, component presence, correct lead clinch direction and solder bridges. The instrument consists of a low power heliumneon laser, an x-y moving iron galvanometer scanner and several folding mirros. A unique shadow signature is detected by silicon photodiodes located at the optium geometry to allow rapid and reliable detection of components with correctly clinched leads. A reflective glint screen is utilized to inspect for a solder bridges. The detected signal are processed and evaluated by a minocomputer which also controls the scan inspection rate of at least 25 components or 50 components holes per second. The return of investment on this instrument for high volume production of printed wirind boards is less than one yea and only slightly longer for medium run military application.
PET Timing Performance Measurement Method Using NEMA NEC Phantom
NASA Astrophysics Data System (ADS)
Wang, Gin-Chung; Li, Xiaoli; Niu, Xiaofeng; Du, Huini; Balakrishnan, Karthik; Ye, Hongwei; Burr, Kent
2016-06-01
When comparing the performance of time-of-flight whole-body PET scanners, timing resolution is one important benchmark. Timing performance is heavily influenced by detector and electronics design. Even for the same scanner design, measured timing resolution is a function of many factors including the activity concentration, geometry and positioning of the radioactive source. Due to lack of measurement standards, the timing resolutions reported in the literature may not be directly comparable and may not describe the timing performance under clinically relevant conditions. In this work we introduce a method which makes use of the data acquired during the standard NEMA Noise-Equivalent-Count-Rate (NECR) measurements, and compare it to several other timing resolution measurement methods. The use of the NEMA NEC phantom, with well-defined dimensions and radioactivity distribution, is attractive because it has been widely accepted in the industry and allows for the characterization of timing resolution across a more relevant range of conditions.
Multiple-energy Techniques in Industrial Computerized Tomography
DOE R&D Accomplishments Database
Schneberk, D.; Martz, H.; Azevedo, S.
1990-08-01
Considerable effort is being applied to develop multiple-energy industrial CT techniques for materials characterization. Multiple-energy CT can provide reliable estimates of effective Z (Z{sub eff}), weight fraction, and rigorous calculations of absolute density, all at the spatial resolution of the scanner. Currently, a wide variety of techniques exist for CT scanners, but each has certain problems and limitations. Ultimately, the best multi-energy CT technique would combine the qualities of accuracy, reliability, and wide range of application, and would require the smallest number of additional measurements. We have developed techniques for calculating material properties of industrial objects that differ somewhat from currently used methods. In this paper, we present our methods for calculating Z{sub eff}, weight fraction, and density. We begin with the simplest case -- methods for multiple-energy CT using isotopic sources -- and proceed to multiple-energy work with x-ray machine sources. The methods discussed here are illustrated on CT scans of PBX-9502 high explosives, a lexan-aluminum phantom, and a cylinder of glass beads used in a preliminary study to determine if CT can resolve three phases: air, water, and a high-Z oil. In the CT project at LLNL, we have constructed several CT scanners of varying scanning geometries using {gamma}- and x-ray sources. In our research, we employed two of these scanners: pencil-beam CAT for CT data using isotopic sources and video-CAT equipped with an IRT micro-focal x-ray machine source.
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Fast, Automated, Scalable Generation of Textured 3D Models of Indoor Environments
2014-12-18
expensive travel and on-site visits. Different applications require models of different complexities, both with and without furniture geometry. The...environment and to localize the system in the environment over time. The datasets shown in this paper were generated by a backpack -mounted system that uses 2D...voxel is found to intersect the line segment from a scanner to a corresponding scan point. If a laser passes through a voxel, that voxel is considered
2009-02-01
topology changes. We used a subset of the TOSCA shape database , [10], consisting of four different objects: cat, dog, male, and female. Each of the...often encountered as acquisition imperfections when the shapes are acquired using a 3D scanner. We used a subset of the TOSCA shape database , consisting...object recognition, Point Based Graphics, Prague, 2007. 18 44. A. Spira and R. Kimmel, An efficient solution to the eikonal equation on parametric
Resource targets for advanced underground coal extraction systems
NASA Technical Reports Server (NTRS)
Hoag, J. H.; Whipple, D. W.; Habib-Agahi, H.; Lavin, M. L.
1982-01-01
Resource targets appropriate for federal sponsorship of research and development of advanced underground coal mining systems are identified. A comprehensive examination of conventional and unconventional coals with particular attention to exceptionally thin and thick seams, steeply dipping beds, and multiple seam geometry was made. The results indicate that the resource of primary importance is flat lying bituminous coal of moderate thickness, under moderate cover, and located within the lower 48 states. Resources of secondary importance are the flat lying multiple seams and thin seams (especially those in Appalachia). Steeply dipping coals, abandoned pillars, and exceptionally thick western coals may be important in some regions of subregions, but the limited tonnage available places them in a position of tertiary importance.
Simulation study of a high performance brain PET system with dodecahedral geometry.
Tao, Weijie; Chen, Gaoyu; Weng, Fenghua; Zan, Yunlong; Zhao, Zhixiang; Peng, Qiyu; Xu, Jianfeng; Huang, Qiu
2018-05-25
In brain imaging, the spherical PET system achieves the highest sensitivity when the solid angle is concerned. However it is not practical. In this work we designed an alternative sphere-like scanner, the dodecahedral scanner, which has a high sensitivity in imaging and a high feasibility to manufacture. We simulated this system and compared the performance with a few other dedicated brain PET systems. Monte Carlo simulations were conducted to generate data of the dedicated brain PET system with the dodecahedral geometry (11 regular pentagon detectors). The data were then reconstructed using the in-house developed software with the fully three-dimensional maximum-likelihood expectation maximization (3D-MLEM) algorithm. Results show that the proposed system has a high sensitivity distribution for the whole field of view (FOV). With a depth-of-interaction (DOI) resolution around 6.67 mm, the proposed system achieves the spatial resolution of 1.98 mm. Our simulation study also shows that the proposed system improves the image contrast and reduces noise compared with a few other dedicated brain PET systems. Finally, simulations with the Hoffman phantom show the potential application of the proposed system in clinical applications. In conclusion, the proposed dodecahedral PET system is potential for widespread applications in high-sensitivity, high-resolution PET imaging, to lower the injected dose. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Multi-pelvis characterisation of articular cartilage geometry.
Gillard, Faye C; Dickinson, Alexander S; Schneider, Urs; Taylor, Andrew C; Browne, Martin
2013-12-01
The shape of the acetabular cartilage follows the contact stress distribution across the joint. Accurate characterisation of this geometry may be useful for the development of acetabular cup devices that are more biomechanically compliant. In this study, the geometry of the acetabular cartilage was characterised by taking plaster moulds of the acetabulum from 24 dry bone human pelvises and digitising the mould shapes using a three-dimensional laser scanner. The articular bone surface geometry was analysed, and the shape of the acetabulum was approximated by fitting a best-fit sphere. To test the hypothesis that the acetabulum is non-spherical, a best-fit ellipsoid was also fitted to the geometry. In each case, points around the acetabular notch edge that disclosed the articular surface geometry were identified, and vectors were drawn between these and the best-fit sphere or ellipsoid centre. The significantly larger z radii (into the pole) of the ellipsoids indicated that the acetabulum was non-spherical and could imply that the kinematics of the hip joint is more complex than purely rotational motion, and the traditional ball-and-socket replacement may need to be updated to reflect this motion. The acetabular notch edges were observed to be curved, with males exhibiting deeper, wider and shorter notches than females, although the difference was not statistically significant (mean: p = 0.30) and supports the use of non-gender-specific models in anatomical studies.
WE-EF-207-09: Single-Scan Dual-Energy CT Using Primary Modulation
DOE Office of Scientific and Technical Information (OSTI.GOV)
Petrongolo, M; Zhu, L
Purpose: Compared with conventional CT, dual energy CT (DECT) provides better material differentiation but requires projection data with two different effective x-ray spectra. Current DECT scanners use either a two-scan setting or costly imaging components, which are not feasible or available on open-gantry cone-beam CT systems. We propose a hardware-based method which utilizes primary modulation to enable single-scan DECT on a conventional CT scanner. The CT imaging geometry of primary modulation is identical to that used in our previous method for scatter removal, making it possible for future combination with effective scatter correction on the same CT scanner. Methods: Wemore » insert an attenuation sheet with a spatially-varying pattern - primary modulator-between the x-ray source and the imaged object. During the CT scan, the modulator selectively hardens the x-ray beam at specific detector locations. Thus, the proposed method simultaneously acquires high and low energy data. High and low energy CT images are then reconstructed from projections with missing data via an iterative CT reconstruction algorithm with gradient weighting. Proof-of-concept studies are performed using a copper modulator on a cone-beam CT system. Results: Our preliminary results on the Catphan(c) 600 phantom indicate that the proposed method for single-scan DECT is able to successfully generate high-quality high and low energy CT images and distinguish different materials through basis material decomposition. By applying correction algorithms and using all of the acquired projection data, we can reconstruct a single CT image of comparable image quality to conventional CT images, i.e., without primary modulation. Conclusion: This work shows great promise in using a primary modulator to perform high-quality single-scan DECT imaging. Future studies will test method performance on anthropomorphic phantoms and perform quantitative analyses on image qualities and DECT decomposition accuracy. We will use simulations to optimize the modulator material and geometry parameters.« less
The future of oil: unconventional fossil fuels.
Chew, Kenneth J
2014-01-13
Unconventional fossil hydrocarbons fall into two categories: resource plays and conversion-sourced hydrocarbons. Resource plays involve the production of accumulations of solid, liquid or gaseous hydro-carbons that have been generated over geological time from organic matter in source rocks. The character of these hydrocarbons may have been modified subsequently, especially in the case of solids and extra-heavy liquids. These unconventional hydrocarbons therefore comprise accumulations of hydrocarbons that are trapped in an unconventional manner and/or whose economic exploitation requires complex and technically advanced production methods. This review focuses primarily on unconventional liquid hydro-carbons. The future potential of unconventional gas, especially shale gas, is also discussed, as it is revolutionizing the energy outlook in North America and elsewhere.
Nanoscale Pore Features and Associated Fluid Behavior in Shale
NASA Astrophysics Data System (ADS)
Cole, D. R.; Striolo, A.
2017-12-01
Unconventional hydrocarbons occurring in economic abundance require greater than industry-standard levels of technology or investment to exploit. Geological formations that host unconventional oil and gas are extraordinarily heterogeneous and exhibit a wide range of physical and chemical features that can vary over many orders of magnitude in length scale. The size, distribution and connectivity of these confined geometries, the chemistry of the solid, the chemistry of the fluids and their physical properties collectively dictate how fluids migrate into and through these micro- and nano-environments, wet and ultimately react with the solid surfaces. Our current understanding of the rates and mechanisms of fluid and mass transport and interaction within these multiporosity systems at the molecular scale is far less robust than we would like. This presentation will take a two-fold approach to this topic area. First, a brief overview is provided that highlights the use of advanced electron microscopy and neutrons scattering methods to quantify the nature of the nanopore system that hosts hydrocarbons in representative gas shale formations such as the Utica, Marcellus and Eagle Ford. Second, results will be presented that leverage the application of state-of-the-art experimental, analytical and computational tools to assess key features of the fluid-matrix interaction relevant to shale settings. The multidisciplinary approaches highlighted will include neutron scattering and NMR experiments, thermodynamic measurements and molecular-level simulations to quantitatively assess molecular properties of C-O-H fluids confined to well-characterized porous media, subjected to temperatures and pressures relevant to subsurface energy systems. These studies conducted in concert are beginning to provide a fundamental understanding at the molecular level of how intrinsically different hydrocarbon-bearing fluids behave in confined geometries compared to bulk systems, and shed light on key geochemical processes such as fluid wetting, competitive sorption and the onset of mineral dissolution and precipitation.
NASA Astrophysics Data System (ADS)
Hattanji, T.; Wasklewicz, T.
2006-12-01
We examined geometry change of a steep first-order channel with a laserscanner before and after a small debris flow. The study site is located in chert area, Ashio Mountains, Japan. On August 12, 2005, a 20-year storm event with maximum 1-hour rainfall of 75.4 mm/h triggered a small landslide at a steep channel head. The sliding material moved as a debris flow along the first-order channel (C3) to the mouth. We successfully measured high-resolution channel topography with the Leica Geosystems High-Definition Surveying Laser Scanner before (April 30) and after the debris-flow event (October 9-11). Width, depth and other related parameters were measured for 30 selected cross sections. Bankfull stage of this first-order channel after the debris-flow event is much higher than two-year flood stage. The magnitude of channel geometry change varies non-linearly in downstream direction. The non-linear variability is attributed to differences in stream bed and bank characteristics. Bedrock-channel reach is less impacted by the debris flow. The largest magnitude changes in the channel geometry parameters occur along colluvially confined channel reaches.
Effect of wafer geometry on lithography chucking processes
NASA Astrophysics Data System (ADS)
Turner, Kevin T.; Sinha, Jaydeep K.
2015-03-01
Wafer flatness during exposure in lithography tools is critical and is becoming more important as feature sizes in devices shrink. While chucks are used to support and flatten the wafer during exposure, it is essential that wafer geometry be controlled as well. Thickness variations of the wafer and high-frequency wafer shape components can lead to poor flatness of the chucked wafer and ultimately patterning problems, such as defocus errors. The objective of this work is to understand how process-induced wafer geometry, resulting from deposited films with non-uniform stress, can lead to high-frequency wafer shape variations that prevent complete chucking in lithography scanners. In this paper, we discuss both the acceptable limits of wafer shape that permit complete chucking to be achieved, and how non-uniform residual stresses in films, either due to patterning or process non-uniformity, can induce high spatial frequency wafer shape components that prevent chucking. This paper describes mechanics models that relate non-uniform film stress to wafer shape and presents results for two example cases. The models and results can be used as a basis for establishing control strategies for managing process-induced wafer geometry in order to avoid wafer flatness-induced errors in lithography processes.
Performance Evaluation of the microPET®—FOCUS-F120
NASA Astrophysics Data System (ADS)
Laforest, Richard; Longford, Desmond; Siegel, Stefan; Newport, Danny F.; Yap, Jeffrey
2007-02-01
microPETreg-Focus-F120 is the latest model of dedicated small animal PET scanners from CTI-Concorde Microsystems LLC, (Knoxville, TN). This scanner, based on the geometry of the microPET-R4, takes advantage of several detector modifications to the coincidence processing electronics that improve the image resolution, sensitivity, and counting rate performance as compared to the predecessor models. This work evaluates the performance of the Focus-F120 system and shows its improvement over the earlier models. In particular, the spatial resolution is shown to improve from 2.32 to 1.69 mm at 5 mm radial distance and the peak absolute sensitivity increases from 4.1% to 7.1% compared to the microPET-R4. The counting rate capability, expressed in noise equivalent counting rate (NEC-1R), was shown to peak at over 800 kcps at 88 MBq for both systems using a mouse phantom. For this small phantom, the NECR counting rate is limited by the data transmission bandwidth between the scanner and the acquisition console. The rat-like phantom showed peak NEC-1R value at 300 kcps at 140 MBq. Evaluation of image quality and quantitation accuracy was also performed using specially designed phantoms and animal experiments
Validation of radiocarpal joint contact models based on images from a clinical MRI scanner.
Johnson, Joshua E; McIff, Terence E; Lee, Phil; Toby, E Bruce; Fischer, Kenneth J
2014-01-01
This study was undertaken to assess magnetic resonance imaging (MRI)-based radiocarpal surface contact models of functional loading in a clinical MRI scanner for future in vivo studies, by comparison with experimental measures from three cadaver forearm specimens. Experimental data were acquired using a Tekscan sensor during simulated light grasp. Magnetic resonance (MR) images were used to obtain model geometry and kinematics (image registration). Peak contact pressures (PPs) and average contact pressures (APs), contact forces and contact areas were determined in the radiolunate and radioscaphoid joints. Contact area was also measured directly from MR images acquired with load and compared with model data. Based on the validation criteria (within 25% of experimental data), out of the six articulations (three specimens with two articulations each), two met the criterion for AP (0%, 14%); one for peak pressure (20%); one for contact force (5%); four for contact area with respect to experiment (8%, 13%, 19% and 23%), and three contact areas met the criterion with respect to direct measurements (14%, 21% and 21%). Absolute differences between model and experimental PPs were reasonably low (within 2.5 MPa). Overall, the results indicate that MRI-based models generated from 3T clinical MR scanner appear sufficient to obtain clinically relevant data.
NASA Astrophysics Data System (ADS)
Klapa, Przemyslaw; Mitka, Bartosz; Zygmunt, Mariusz
2017-12-01
Capability of obtaining a multimillion point cloud in a very short time has made the Terrestrial Laser Scanning (TLS) a widely used tool in many fields of science and technology. The TLS accuracy matches traditional devices used in land surveying (tacheometry, GNSS - RTK), but like any measurement it is burdened with error which affects the precise identification of objects based on their image in the form of a point cloud. The point’s coordinates are determined indirectly by means of measuring the angles and calculating the time of travel of the electromagnetic wave. Each such component has a measurement error which is translated into the final result. The XYZ coordinates of a measuring point are determined with some uncertainty and the very accuracy of determining these coordinates is reduced as the distance to the instrument increases. The paper presents the results of examination of geometrical stability of a point cloud obtained by means terrestrial laser scanner and accuracy evaluation of solids determined using the cloud. Leica P40 scanner and two different settings of measuring points were used in the tests. The first concept involved placing a few balls in the field and then scanning them from various sides at similar distances. The second part of measurement involved placing balls and scanning them a few times from one side but at varying distances from the instrument to the object. Each measurement encompassed a scan of the object with automatic determination of its position and geometry. The desk studies involved a semiautomatic fitting of solids and measurement of their geometrical elements, and comparison of parameters that determine their geometry and location in space. The differences of measures of geometrical elements of balls and translations vectors of the solids centres indicate the geometrical changes of the point cloud depending on the scanning distance and parameters. The results indicate the changes in the geometry of scanned objects depending on the point cloud quality and distance from the measuring instrument. Varying geometrical dimensions of the same element suggest also that the point cloud does not keep a stable geometry of measured objects.
Contrast-to-noise ratio optimization for a prototype phase-contrast computed tomography scanner.
Müller, Mark; Yaroshenko, Andre; Velroyen, Astrid; Bech, Martin; Tapfer, Arne; Pauwels, Bart; Bruyndonckx, Peter; Sasov, Alexander; Pfeiffer, Franz
2015-12-01
In the field of biomedical X-ray imaging, novel techniques, such as phase-contrast and dark-field imaging, have the potential to enhance the contrast and provide complementary structural information about a specimen. In this paper, a first prototype of a preclinical X-ray phase-contrast CT scanner based on a Talbot-Lau interferometer is characterized. We present a study of the contrast-to-noise ratios for attenuation and phase-contrast images acquired with the prototype scanner. The shown results are based on a series of projection images and tomographic data sets of a plastic phantom in phase and attenuation-contrast recorded with varying acquisition settings. Subsequently, the signal and noise distribution of different regions in the phantom were determined. We present a novel method for estimation of contrast-to-noise ratios for projection images based on the cylindrical geometry of the phantom. Analytical functions, representing the expected signal in phase and attenuation-contrast for a circular object, are fitted to individual line profiles of the projection data. The free parameter of the fit function is used to estimate the contrast and the goodness of the fit is determined to assess the noise in the respective signal. The results depict the dependence of the contrast-to-noise ratios on the applied source voltages, the number of steps of the phase stepping routine, and the exposure times for an individual step. Moreover, the influence of the number of projection angles on the image quality of CT slices is investigated. Finally, the implications for future imaging purposes with the scanner are discussed.
NASA Astrophysics Data System (ADS)
Heinz, Erik; Eling, Christian; Wieland, Markus; Klingbeil, Lasse; Kuhlmann, Heiner
2015-12-01
In recent years, kinematic laser scanning has become increasingly popular because it offers many benefits compared to static laser scanning. The advantages include both saving of time in the georeferencing and a more favorable scanning geometry. Often mobile laser scanning systems are installed on wheeled platforms, which may not reach all parts of the object. Hence, there is an interest in the development of portable systems, which remain operational even in inaccessible areas. The development of such a portable laser scanning system is presented in this paper. It consists of a lightweight direct georeferencing unit for the position and attitude determination and a small low-cost 2D laser scanner. This setup provides advantages over existing portable systems that employ heavy and expensive 3D laser scanners in a profiling mode. A special emphasis is placed on the system calibration, i. e. the determination of the transformation between the coordinate frames of the direct georeferencing unit and the 2D laser scanner. To this end, a calibration field is used, which consists of differently orientated georeferenced planar surfaces, leading to estimates for the lever arms and boresight angles with an accuracy of mm and one-tenth of a degree. Finally, point clouds of the mobile laser scanning system are compared with georeferenced point clouds of a high-precision 3D laser scanner. Accordingly, the accuracy of the system is in the order of cm to dm. This is in good agreement with the expected accuracy, which has been derived from the error propagation of previously estimated variance components.
TandemPET-A High Resolution, Small Animal, Virtual Pinhole-Based PET Scanner: Initial Design Study
NASA Astrophysics Data System (ADS)
Raylman, Raymond R.; Stolin, Alexander V.; Martone, Peter F.; Smith, Mark F.
2016-02-01
Mice are the perhaps the most common species of rodents used in biomedical research, but many of the current generation of small animal PET scanners are non-optimal for imaging these small rodents due to their relatively low resolution. Consequently, a number of researchers have investigated the development of high-resolution scanners to address this need. In this investigation, the design of a novel, high-resolution system based on the dual-detector, virtual-pinhole PET concept was explored via Monte Carlo simulations. Specifically, this system, called TandemPET, consists of a 5 cm × 5 cm high-resolution detector made-up of a 90 × 90 array of 0.5 mm × 0.5 × 10 mm (pitch = 0.55 mm) LYSO detector elements in coincidence with a lower resolution detector consisting of a 68 × 68 array of 1.5 mm × 1.5 mm × 10 mm LYSO detector elements (total size = 10.5 cm × 10.5 cm). Analyses indicated that TandemPET's optimal geometry is to position the high-resolution detector 3 cm from the center-of-rotation, with the lower resolution detector positioned 9 cm from center. Measurements using modified NEMA NU4-2008-based protocols revealed that the spatial resolution of the system is 0.5 mm FWHM, after correction of positron range effects. Peak sensitivity is 2.1%, which is comparable to current small animal PET scanners. Images from a digital mouse brain phantom demonstrated the potential of the system for identifying important neurological structures.
Unconventional Aqueous Humor Outflow: A Review
Johnson, Mark; McLaren, Jay W.; Overby, Darryl R.
2016-01-01
Aqueous humor flows out of the eye primarily through the conventional outflow pathway that includes the trabecular meshwork and Schlemm's canal. However, a fraction of aqueous humor passes through an alternative or ‘unconventional’ route that includes the ciliary muscle, supraciliary and suprachoroidal spaces. From there, unconventional outflow may drain through two pathways: a uveoscleral pathway where aqueous drains across the sclera to be resorbed by orbital vessels, and a uveovortex pathway where aqueous humor enters the choroid to drain through the vortex veins. We review the anatomy, physiology and pharmacology of these pathways. We also discuss methods to determine unconventional outflow rate, including direct techniques that use radioactive or fluorescent tracers recovered from tissues in the unconventional pathway and indirect methods that estimate unconventional outflow based on total outflow over a range of pressures. Indirect methods are subject to a number of assumptions and generally give poor agreement with tracer measurements. We review the variety of animal models that have been used to study conventional and unconventional outflow. The mouse appears to be a promising model because it captures several aspects of conventional and unconventional outflow dynamics common to humans, although questions remain regarding the magnitude of unconventional outflow in mice. Finally, we review future directions. There is a clear need to develop improved methods for measuring unconventional outflow in both animals and humans. PMID:26850315
Pallone, Matthew J.; Meaney, Paul M.; Paulsen, Keith D.
2012-01-01
Purpose: Microwave tomographic image quality can be improved significantly with prior knowledge of the breast surface geometry. The authors have developed a novel laser scanning system capable of accurately recovering surface renderings of breast-shaped phantoms immersed within a cylindrical tank of coupling fluid which resides completely external to the tank (and the aqueous environment) and overcomes the challenges associated with the optical distortions caused by refraction from the air, tank wall, and liquid bath interfaces. Methods: The scanner utilizes two laser line generators and a small CCD camera mounted concentrically on a rotating gantry about the microwave imaging tank. Various calibration methods were considered for optimizing the accuracy of the scanner in the presence of the optical distortions including traditional ray tracing and image registration approaches. In this paper, the authors describe the construction and operation of the laser scanner, compare the efficacy of several calibration methods—including analytical ray tracing and piecewise linear, polynomial, locally weighted mean, and thin-plate-spline (TPS) image registrations—and report outcomes from preliminary phantom experiments. Results: The results show that errors in calibrating camera angles and position prevented analytical ray tracing from achieving submillimeter accuracy in the surface renderings obtained from our scanner configuration. Conversely, calibration by image registration reliably attained mean surface errors of less than 0.5 mm depending on the geometric complexity of the object scanned. While each of the image registration approaches outperformed the ray tracing strategy, the authors found global polynomial methods produced the best compromise between average surface error and scanner robustness. Conclusions: The laser scanning system provides a fast and accurate method of three dimensional surface capture in the aqueous environment commonly found in microwave breast imaging. Optical distortions imposed by the imaging tank and coupling bath diminished the effectiveness of the ray tracing approach; however, calibration through image registration techniques reliably produced scans of submillimeter accuracy. Tests of the system with breast-shaped phantoms demonstrated the successful implementation of the scanner for the intended application. PMID:22755695
NASA Astrophysics Data System (ADS)
Xu, Y.; Wuu, Cheng-Shie
2013-02-01
The performance of a fast optical computed tomography (CT) scanner based on a point laser source, a small area photodiode detector, and two optical-grade Fresnel lenses is evaluated. The OCTOPUS™-10× optical CT scanner (MGS Research Inc., Madison, CT) is an upgrade of the OCTOPUS™ research scanner with improved design for faster motion of the laser beam and faster data acquisition process. The motion of the laser beam in the new configuration is driven by the rotational motion of a scanning mirror. The center of the scanning mirror and the center of the photodiode detector are adjusted to be on the focal points of two coaxial Fresnel lenses. A glass water tank is placed between the two Fresnel lenses to house gel phantoms and matching liquids. The laser beam scans over the water tank in parallel beam geometry for projection data as the scanning mirror rotates at a frequency faster than 0.1 s per circle. Signal sampling is performed independently of the motion of the scanning mirror, to reduce the processing time for the synchronization of the stepper motors and the data acquisition board. An in-house developed reference image normalization mechanism is added to the image reconstruction program to correct the non-uniform light transmitting property of the Fresnel lenses. Technical issues with regard to the new design of the scanner are addressed, including projection data extraction from raw data samples, non-uniform pixel averaging and reference image normalization. To evaluate the dosimetric accuracy of the scanner, the reconstructed images from a 16 MeV, 6 cm × 6 cm electron field irradiation were compared with those from the Eclipse treatment planning system (Varian Corporation, Palo Alto, CA). The spatial resolution of the scanner is demonstrated to be of sub-millimeter accuracy. The effectiveness of the reference normalization method for correcting the non-uniform light transmitting property of the Fresnel lenses is analyzed. A sub-millimeter accuracy of the phantom positioning between the reference scan and the actual scan is demonstrated to be essential. The fast scanner is shown to be able to scan gel phantoms with a wider field of view (5 mm from the edge of the scanned dosimeters) and at a speed 10 to 20 times faster than the OCTOPUS™ scanner. A large uncertainty of 5% (defined as the ratio of the standard deviation to the mean) is typically observed in the reconstructed images, owing to the inaccuracy in the phantom positioning process. Methods for further improvement of the accuracy of the in-house modified OCTOPUS™-10× scanner are discussed.
Broadband Focusing Acoustic Lens Based on Fractal Metamaterials
Song, Gang Yong; Huang, Bei; Dong, Hui Yuan; Cheng, Qiang; Cui, Tie Jun
2016-01-01
Acoustic metamaterials are artificial structures which can manipulate sound waves through their unconventional effective properties. Different from the locally resonant elements proposed in earlier studies, we propose an alternate route to realize acoustic metamaterials with both low loss and large refractive indices. We describe a new kind of acoustic metamaterial element with the fractal geometry. Due to the self-similar properties of the proposed structure, broadband acoustic responses may arise within a broad frequency range, making it a good candidate for a number of applications, such as super-resolution imaging and acoustic tunneling. A flat acoustic lens is designed and experimentally verified using this approach, showing excellent focusing abilities from 2 kHz and 5 kHz in the measured results. PMID:27782216
NASA Technical Reports Server (NTRS)
Martin, D. L.; Perry, M. J.
1994-01-01
Water-leaving radiances and phytoplankton pigment concentrations are calculated from coastal zone color scanner (CZCS) radiance measurements by removing atmospheric Rayleigh and aerosol radiances from the total radiance signal measured at the satellite. The single greatest source of error in CZCS atmospheric correction algorithms in the assumption that these Rayleigh and aerosol radiances are separable. Multiple-scattering interactions between Rayleigh and aerosol components cause systematic errors in calculated aerosol radiances, and the magnitude of these errors is dependent on aerosol type and optical depth and on satellite viewing geometry. A technique was developed which extends the results of previous radiative transfer modeling by Gordon and Castano to predict the magnitude of these systematic errors for simulated CZCS orbital passes in which the ocean is viewed through a modeled, physically realistic atmosphere. The simulated image mathematically duplicates the exact satellite, Sun, and pixel locations of an actual CZCS image. Errors in the aerosol radiance at 443 nm are calculated for a range of aerosol optical depths. When pixels in the simulated image exceed an error threshhold, the corresponding pixels in the actual CZCS image are flagged and excluded from further analysis or from use in image compositing or compilation of pigment concentration databases. Studies based on time series analyses or compositing of CZCS imagery which do not address Rayleigh-aerosol multiple scattering should be interpreted cautiously, since the fundamental assumption used in their atmospheric correction algorithm is flawed.
Application of Reservoir Flow Simulation Integrated with Geomechanics in Unconventional Tight Play
NASA Astrophysics Data System (ADS)
Lin, Menglu; Chen, Shengnan; Mbia, Ernest; Chen, Zhangxing
2018-01-01
Multistage hydraulic fracturing techniques, combined with horizontal drilling, have enabled commercial production from the vast reserves of unconventional tight formations. During hydraulic fracturing, fracturing fluid and proppants are pumped into the reservoir matrix to create the hydraulic fractures. Understanding the propagation mechanism of hydraulic fractures is essential to estimate their properties, such as half-length. In addition, natural fractures are often present in tight formations, which might be activated during the fracturing process and contribute to the post-stimulation well production rates. In this study, reservoir simulation is integrated with rock geomechanics to predict the well post-stimulation productivities. Firstly, a reservoir geological model is built based on the field data collected from the Montney formation in the Western Canadian Sedimentary Basin. The hydraulic fracturing process is then simulated through an integrated approach of fracturing fluid injection, rock geomechanics, and tensile failure criteria. In such a process, the reservoir pore pressure increases with a continuous injection of the fracturing fluid and proppants, decreasing the effective stress exerted on the rock matrix accordingly as the overburden pressure remains constant. Once the effective stress drops to a threshold value, tensile failure of the reservoir rock occurs, creating hydraulic fractures in the formation. The early production history of the stimulated well is history-matched to validate the predicted fracture geometries (e.g., half-length) generated from the fracturing simulation process. The effects of the natural fracture properties and well bottom-hole pressures on well productivity are also studied. It has been found that nearly 40% of hydraulic fractures propagate in the beginning stage (the pad step) of the fracturing schedule. In addition, well post-stimulation productivity will increase significantly if the natural fractures are propped or partially propped by the proppants. This paper provides insights on fracture propagation and can be a reference for fracturing treatments in unconventional tight reservoirs.
Martin, David P; Blachly, Patrick G; Marts, Amy R; Woodruff, Tessa M; de Oliveira, César A F; McCammon, J Andrew; Tierney, David L; Cohen, Seth M
2014-04-09
The binding of three closely related chelators: 5-hydroxy-2-methyl-4H-pyran-4-thione (allothiomaltol, ATM), 3-hydroxy-2-methyl-4H-pyran-4-thione (thiomaltol, TM), and 3-hydroxy-4H-pyran-4-thione (thiopyromeconic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated. Two of these ligands display a monodentate mode of coordination to the active site Zn(2+) ion in hCAII that is not recapitulated in model complexes of the enzyme active site. This unprecedented binding mode in the hCAII-thiomaltol complex has been characterized by both X-ray crystallography and X-ray spectroscopy. In addition, the steric restrictions of the active site force the ligands into a 'flattened' mode of coordination compared with inorganic model complexes. This change in geometry has been shown by density functional computations to significantly decrease the strength of the metal-ligand binding. Collectively, these data demonstrate that the mode of binding by small metal-binding groups can be significantly influenced by the protein active site. Diminishing the strength of the metal-ligand bond results in unconventional modes of metal coordination not found in typical coordination compounds or even carefully engineered active site models, and understanding these effects is critical to the rational design of inhibitors that target clinically relevant metalloproteins.
Artifact correction in diffusion MRI of non-human primate brains on a clinical 3T scanner.
Zhang, Xiaodong; Kirsch, John E; Zhong, Xiaodong
2016-02-01
Smearing artifacts were observed and investigated in diffusion tensor imaging (DTI) studies of macaque monkeys on a clinical whole-body 3T scanner. Four adult macaques were utilized to evaluate DTI artifacts. DTI images were acquired with a single-shot echo-planar imaging (EPI) sequence using a parallel imaging technique. The smearing artifacts observed on the diffusion-weighted images and fractional anisotropy maps were caused by the incomplete fat suppression due to the irregular macaque frontal skull geometry and anatomy. The artifact can be reduced substantially using a novel three-dimensional (3D) shimming procedure. The smearing artifacts observed on diffusion weighted images and fractional anisotropy (FA) maps of macaque brains can be reduced substantially using a robust 3D shimming approach. The DTI protocol combined with the shimming procedure could be a robust approach to examine brain connectivity and white matter integrity of non-human primates using a conventional clinical setting. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
NASA Astrophysics Data System (ADS)
Ostendorf, Ralf; Butschek, Lorenz; Merten, André; Grahmann, Jan; Jarvis, Jan; Hugger, Stefan; Fuchs, Frank; Wagner, Joachim
2016-02-01
We present spectroscopic measurements performed with an EC-QCL combining a broadly tunable quantum cascade laser chip with a tuning range of more than 300 cm-1 and a resonantly driven MOEMS scanner with an integrated diffraction grating for wavelength selection in Littrow configuration. The grating geometry was optimized to provide high diffraction efficiency over the wide tuning range of the QCL, thus assuring high power density and high spectral resolution in the MIR range. The MOEMS scanner has a resonance frequency of 1 kHz, hence allowing for two full wavelength scans, one up and the other downwards, within 1 ms. The capability for real-time spectroscopic sensing based on MOEMS EC-QCLs is demonstrated by transmission measurements performed on polystyrene reference absorber sheets as well as on gaseous samples of carbon monoxide. For the latter one, a large portion of the characteristic CO absorption band containing several absorption lines in the range of 2070 cm-1 to 2280 cm-1 can be monitored in real-time.
Proposal of an innovative benchmark for comparison of the performance of contactless digitizers
NASA Astrophysics Data System (ADS)
Iuliano, Luca; Minetola, Paolo; Salmi, Alessandro
2010-10-01
Thanks to the improving performances of 3D optical scanners, in terms of accuracy and repeatability, reverse engineering applications have extended from CAD model design or reconstruction to quality control. Today, contactless digitizing devices constitute a good alternative to coordinate measuring machines (CMMs) for the inspection of certain parts. The German guideline VDI/VDE 2634 is the only reference to evaluate whether 3D optical measuring systems comply with the declared or required performance specifications. Nevertheless it is difficult to compare the performance of different scanners referring to such a guideline. An adequate novel benchmark is proposed in this paper: focusing on the inspection of production tools (moulds), the innovative test piece was designed using common geometries and free-form surfaces. The reference part is intended to be employed for the evaluation of the performance of several contactless digitizing devices in computer-aided inspection, considering dimensional and geometrical tolerances as well as other quantitative and qualitative criteria.
Unconventional Deterrence Strategy
2005-06-01
200 words) This thesis examines a largely unexplored area of deterrence theory – unconventional deterrence. Unconventional deterrence is defined...hypothesis of deterrence theory which says that the balance of the opponents’ military capabilities is the basic determinant of successful deterrence...
NASA Astrophysics Data System (ADS)
Gu, Z.; Bao, Q.; Taschereau, R.; Wang, H.; Bai, B.; Chatziioannou, A. F.
2014-06-01
Small animal positron emission tomography (PET) systems are often designed by employing close geometry configurations. Due to the different characteristics caused by geometrical factors, these tomographs require data acquisition protocols that differ from those optimized for conventional large diameter ring systems. In this work we optimized the energy window for data acquisitions with PETbox4, a 50 mm detector separation (box-like geometry) pre-clinical PET scanner, using the Geant4 Application for Tomographic Emission (GATE). The fractions of different types of events were estimated using a voxelized phantom including a mouse as well as its supporting chamber, mimicking a realistic mouse imaging environment. Separate code was developed to extract additional information about the gamma interactions for more accurate event type classification. Three types of detector backscatter events were identified in addition to the trues, phantom scatters and randoms. The energy window was optimized based on the noise equivalent count rate (NECR) and scatter fraction (SF) with lower-level discriminators (LLD) corresponding to energies from 150 keV to 450 keV. The results were validated based on the calculated image uniformity, spillover ratio (SOR) and recovery coefficient (RC) from physical measurements using the National Electrical Manufacturers Association (NEMA) NU-4 image quality phantom. These results indicate that when PETbox4 is operated with a more narrow energy window (350-650 keV), detector backscatter rejection is unnecessary. For the NEMA NU-4 image quality phantom, the SOR for the water chamber decreases by about 45% from 15.1% to 8.3%, and the SOR for the air chamber decreases by 31% from 12.0% to 8.3% at the LLDs of 150 and 350 keV, without obvious change in uniformity, further supporting the simulation based optimization. The optimization described in this work is not limited to PETbox4, but also applicable or helpful to other small inner diameter geometry scanners.
Interfacial sciences in unconventional petroleum production: from fundamentals to applications.
He, Lin; Lin, Feng; Li, Xingang; Sui, Hong; Xu, Zhenghe
2015-08-07
With the ever increasing demand for energy to meet the needs of growth in population and improvement in the living standards in particular in developing countries, the abundant unconventional oil reserves (about 70% of total world oil), such as heavy oil, oil/tar sands and shale oil, are playing an increasingly important role in securing global energy supply. Compared with the conventional reserves unconventional oil reserves are characterized by extremely high viscosity and density, combined with complex chemistry. As a result, petroleum production from unconventional oil reserves is much more difficult and costly with more serious environmental impacts. As a key underpinning science, understanding the interfacial phenomena involved in unconventional petroleum production, such as oil liberation from host rocks, oil-water emulsions and demulsification, is critical for developing novel processes to improve oil production while reducing GHG emission and other environmental impacts at a lower operating cost. In the past decade, significant efforts and advances have been made in applying the principles of interfacial sciences to better understand complex unconventional oil-systems, while many environmental and production challenges remain. In this critical review, the recent research findings and progress in the interfacial sciences related to unconventional petroleum production are critically reviewed. In particular, the chemistry of unconventional oils, liberation mechanisms of oil from host rocks and mechanisms of emulsion stability and destabilization in unconventional oil production systems are discussed in detail. This review also seeks to summarize the current state-of-the-art characterization techniques and brings forward the challenges and opportunities for future research in this important field of physical chemistry and petroleum.
Spelleken, E; Crowe, S B; Sutherland, B; Challens, C; Kairn, T
2018-03-01
Gafchromic EBT3 film is widely used for patient specific quality assurance of complex treatment plans. Film dosimetry techniques commonly involve the use of transmission scanning to produce TIFF files, which are analysed using a non-linear calibration relationship between the dose and red channel net optical density (netOD). Numerous film calibration techniques featured in the literature have not been independently verified or evaluated. A range of previously published film dosimetry techniques were re-evaluated, to identify whether these methods produce better results than the commonly-used non-linear, netOD method. EBT3 film was irradiated at calibration doses between 0 and 4000 cGy and 25 pieces of film were irradiated at 200 cGy to evaluate uniformity. The film was scanned using two different scanners: The Epson Perfection V800 and the Epson Expression 10000XL. Calibration curves, uncertainty in the fit of the curve, overall uncertainty and uniformity were calculated following the methods described by the different calibration techniques. It was found that protocols based on a conventional film dosimetry technique produced results that were accurate and uniform to within 1%, while some of the unconventional techniques produced much higher uncertainties (> 25% for some techniques). Some of the uncommon methods produced reliable results when irradiated to the standard treatment doses (< 400 cGy), however none could be recommended as an efficient or accurate replacement for a common film analysis technique which uses transmission scanning, red colour channel analysis, netOD and a non-linear calibration curve for measuring doses up to 4000 cGy when using EBT3 film.
Study of unconventional aircraft engines designed for low energy consumption
NASA Technical Reports Server (NTRS)
Neitzel, R. E.; Hirschkron, R.; Johnston, R. P.
1976-01-01
A study of unconventional engine cycle concepts, which may offer significantly lower energy consumption than conventional subsonic transport turbofans, is described herein. A number of unconventional engine concepts were identified and parametrically studied to determine their relative fuel-saving potential. Based on results from these studies, regenerative, geared, and variable-boost turbofans, and combinations thereof, were selected along with advanced turboprop cycles for further evaluation and refinement. Preliminary aerodynamic and mechanical designs of these unconventional engine configurations were conducted and mission performance was compared to a conventional, direct-drive turofan reference engine. Consideration is given to the unconventional concepts, and their state of readiness for application. Areas of needed technology advancement are identified.
Ng, Jeremy Y; Boon, Heather S; Thompson, Alison K; Whitehead, Cynthia R
2016-05-20
Medical pluralism has flourished throughout the Western world in spite of efforts to legitimize Western biomedical healthcare as "conventional medicine" and thereby relegate all non-physician-related forms of healthcare to an "other" category. These "other" practitioners have been referred to as "unconventional", "alternative" and "complementary", among other terms throughout the past half century. This study investigates the discourses surrounding the changes in the terms, and their meanings, used to describe unconventional medicine in North America. Terms identified by the literature as synonymous to unconventional medicine were searched using the Scopus database. A textual analysis following the method described by Kripendorff 2013 was subsequently performed on the five most highly-cited unconventional medicine-related peer-reviewed literature published between 1970 and 2013. Five commonly-used, unconventional medicine-related terms were identified. Authors using "complementary and alternative", "complementary", "alternative", or "unconventional" tended to define them by what they are not (e.g., therapies not taught/used in conventional medicine, therapy demands not met by conventional medicine, and therapies that lack research on safety, efficacy and effectiveness). Authors defined "integrated/integrative" medicine by what it is (e.g., a new model of healthcare, the combining of both conventional and unconventional therapies, accounting for the whole person, and preventative maintenance of health). Authors who defined terms by "what is not" stressed that the purpose of conducting research in this area was solely to create knowledge. Comparatively, authors who defined terms by "what is" sought to advocate for the evidence-based combination of unconventional and conventional medicines. Both author groups used scientific rhetoric to define unconventional medical practices. This emergence of two groups of authors who used two different sets of terms to refer to the concept of "unconventional medicine" may explain why some journals, practitioner associations and research/practice centres may choose to use both "what is not" and "what is" terms in their discourse to attract interest from both groups. Since each of the two groups of terms (and authors who use them) has different meanings and goals, the evolution of this discourse will continue to be an interesting phenomenon to explore in the future.
NASA Astrophysics Data System (ADS)
Sarracanie, Mathieu; Lapierre, Cristen D.; Salameh, Najat; Waddington, David E. J.; Witzel, Thomas; Rosen, Matthew S.
2015-10-01
Magnetic Resonance Imaging (MRI) is unparalleled in its ability to visualize anatomical structure and function non-invasively with high spatial and temporal resolution. Yet to overcome the low sensitivity inherent in inductive detection of weakly polarized nuclear spins, the vast majority of clinical MRI scanners employ superconducting magnets producing very high magnetic fields. Commonly found at 1.5-3 tesla (T), these powerful magnets are massive and have very strict infrastructure demands that preclude operation in many environments. MRI scanners are costly to purchase, site, and maintain, with the purchase price approaching $1 M per tesla (T) of magnetic field. We present here a remarkably simple, non-cryogenic approach to high-performance human MRI at ultra-low magnetic field, whereby modern under-sampling strategies are combined with fully-refocused dynamic spin control using steady-state free precession techniques. At 6.5 mT (more than 450 times lower than clinical MRI scanners) we demonstrate (2.5 × 3.5 × 8.5) mm3 imaging resolution in the living human brain using a simple, open-geometry electromagnet, with 3D image acquisition over the entire brain in 6 minutes. We contend that these practical ultra-low magnetic field implementations of MRI (<10 mT) will complement traditional MRI, providing clinically relevant images and setting new standards for affordable (<$50,000) and robust portable devices.
Muralikrishnan, Bala; Rachakonda, Prem; Lee, Vincent; Shilling, Meghan; Sawyer, Daniel; Cheok, Geraldine; Cournoyer, Luc
2017-12-01
Terrestrial laser scanners (TLS) are a class of 3D imaging systems that produce a 3D point cloud by measuring the range and two angles to a point. The fundamental measurement of a TLS is range. Relative range error is one component of the overall range error of TLS and its estimation is therefore an important aspect in establishing metrological traceability of measurements performed using these systems. Target geometry is an important aspect to consider when realizing the relative range tests. The recently published ASTM E2938-15 mandates the use of a plate target for the relative range tests. While a plate target may reasonably be expected to produce distortion free data even at far distances, the target itself needs careful alignment at each of the relative range test positions. In this paper, we discuss relative range experiments performed using a plate target and then address the advantages and limitations of using a sphere target. We then present a novel dual-sphere-plate target that draws from the advantages of the sphere and the plate without the associated limitations. The spheres in the dual-sphere-plate target are used simply as fiducials to identify a point on the surface of the plate that is common to both the scanner and the reference instrument, thus overcoming the need to carefully align the target.
Zink, F E; McCollough, C H
1994-08-01
The unique geometry of electron-beam CT (EBCT) scanners produces radiation dose profiles with widths which can be considerably different from the corresponding nominal scan width. Additionally, EBCT scanners produce both complex (multiple-slice) and narrow (3 mm) radiation profiles. This work describes the measurement of the axial dose distribution from EBCT within a scattering phantom using film dosimetry methods, which offer increased convenience and spatial resolution compared to thermoluminescent dosimetry (TLD) techniques. Therapy localization film was cut into 8 x 220 mm strips and placed within specially constructed light-tight holders for placement within the cavities of a CT Dose Index (CTDI) phantom. The film was calibrated using a conventional overhead x-ray tube with spectral characteristics matched to the EBCT scanner (130 kVp, 10 mm A1 HVL). The films were digitized at five samples per mm and calibrated dose profiles plotted as a function of z-axis position. Errors due to angle-of-incidence and beam hardening were estimated to be less than 5% and 10%, respectively. The integral exposure under film dose profiles agreed with ion-chamber measurements to within 15%. Exposures measured along the radiation profile differed from TLD measurements by an average of 5%. The film technique provided acceptable accuracy and convenience in comparison to conventional TLD methods, and allowed high spatial-resolution measurement of EBCT radiation dose profiles.
Physical and clinical performance of the mCT time-of-flight PET/CT scanner.
Jakoby, B W; Bercier, Y; Conti, M; Casey, M E; Bendriem, B; Townsend, D W
2011-04-21
Time-of-flight (TOF) measurement capability promises to improve PET image quality. We characterized the physical and clinical PET performance of the first Biograph mCT TOF PET/CT scanner (Siemens Medical Solutions USA, Inc.) in comparison with its predecessor, the Biograph TruePoint TrueV. In particular, we defined the improvements with TOF. The physical performance was evaluated according to the National Electrical Manufacturers Association (NEMA) NU 2-2007 standard with additional measurements to specifically address the TOF capability. Patient data were analyzed to obtain the clinical performance of the scanner. As expected for the same size crystal detectors, a similar spatial resolution was measured on the mCT as on the TruePoint TrueV. The mCT demonstrated modestly higher sensitivity (increase by 19.7 ± 2.8%) and peak noise equivalent count rate (NECR) (increase by 15.5 ± 5.7%) with similar scatter fractions. The energy, time and spatial resolutions for a varying single count rate of up to 55 Mcps resulted in 11.5 ± 0.2% (FWHM), 527.5 ± 4.9 ps (FWHM) and 4.1 ± 0.0 mm (FWHM), respectively. With the addition of TOF, the mCT also produced substantially higher image contrast recovery and signal-to-noise ratios in a clinically-relevant phantom geometry. The benefits of TOF were clearly demonstrated in representative patient images.
An Efficient, Hierarchical Viewpoint Planning Strategy for Terrestrial Laser Scanner Networks
NASA Astrophysics Data System (ADS)
Jia, F.; Lichti, D. D.
2018-05-01
Terrestrial laser scanner (TLS) techniques have been widely adopted in a variety of applications. However, unlike in geodesy or photogrammetry, insufficient attention has been paid to the optimal TLS network design. It is valuable to develop a complete design system that can automatically provide an optimal plan, especially for high-accuracy, large-volume scanning networks. To achieve this goal, one should look at the "optimality" of the solution as well as the computational complexity in reaching it. In this paper, a hierarchical TLS viewpoint planning strategy is developed to solve the optimal scanner placement problems. If one targeted object to be scanned is simplified as discretized wall segments, any possible viewpoint can be evaluated by a score table representing its visible segments under certain scanning geometry constraints. Thus, the design goal is to find a minimum number of viewpoints that achieves complete coverage of all wall segments. The efficiency is improved by densifying viewpoints hierarchically, instead of a "brute force" search within the entire workspace. The experiment environments in this paper were simulated from two buildings located on University of Calgary campus. Compared with the "brute force" strategy in terms of the quality of the solutions and the runtime, it is shown that the proposed strategy can provide a scanning network with a compatible quality but with more than a 70 % time saving.
Physical and clinical performance of the mCT time-of-flight PET/CT scanner
NASA Astrophysics Data System (ADS)
Jakoby, B. W.; Bercier, Y.; Conti, M.; Casey, M. E.; Bendriem, B.; Townsend, D. W.
2011-04-01
Time-of-flight (TOF) measurement capability promises to improve PET image quality. We characterized the physical and clinical PET performance of the first Biograph mCT TOF PET/CT scanner (Siemens Medical Solutions USA, Inc.) in comparison with its predecessor, the Biograph TruePoint TrueV. In particular, we defined the improvements with TOF. The physical performance was evaluated according to the National Electrical Manufacturers Association (NEMA) NU 2-2007 standard with additional measurements to specifically address the TOF capability. Patient data were analyzed to obtain the clinical performance of the scanner. As expected for the same size crystal detectors, a similar spatial resolution was measured on the mCT as on the TruePoint TrueV. The mCT demonstrated modestly higher sensitivity (increase by 19.7 ± 2.8%) and peak noise equivalent count rate (NECR) (increase by 15.5 ± 5.7%) with similar scatter fractions. The energy, time and spatial resolutions for a varying single count rate of up to 55 Mcps resulted in 11.5 ± 0.2% (FWHM), 527.5 ± 4.9 ps (FWHM) and 4.1 ± 0.0 mm (FWHM), respectively. With the addition of TOF, the mCT also produced substantially higher image contrast recovery and signal-to-noise ratios in a clinically-relevant phantom geometry. The benefits of TOF were clearly demonstrated in representative patient images.
Positron emission particle tracking using a modular positron camera
NASA Astrophysics Data System (ADS)
Parker, D. J.; Leadbeater, T. W.; Fan, X.; Hausard, M. N.; Ingram, A.; Yang, Z.
2009-06-01
The technique of positron emission particle tracking (PEPT), developed at Birmingham in the early 1990s, enables a radioactively labelled tracer particle to be accurately tracked as it moves between the detectors of a "positron camera". In 1999 the original Birmingham positron camera, which consisted of a pair of MWPCs, was replaced by a system comprising two NaI(Tl) gamma camera heads operating in coincidence. This system has been successfully used for PEPT studies of a wide range of granular and fluid flow processes. More recently a modular positron camera has been developed using a number of the bismuth germanate (BGO) block detectors from standard PET scanners (CTI ECAT 930 and 950 series). This camera has flexible geometry, is transportable, and is capable of delivering high data rates. This paper presents simple models of its performance, and initial experience of its use in a range of geometries and applications.
Salmingo, Remel A; Tadano, Shigeru; Fujisaki, Kazuhiro; Abe, Yuichiro; Ito, Manabu
2012-05-01
Scoliosis is defined as a spinal pathology characterized as a three-dimensional deformity of the spine combined with vertebral rotation. Treatment for severe scoliosis is achieved when the scoliotic spine is surgically corrected and fixed using implanted rods and screws. Several studies performed biomechanical modeling and corrective forces measurements of scoliosis correction. These studies were able to predict the clinical outcome and measured the corrective forces acting on screws, however, they were not able to measure the intraoperative three-dimensional geometry of the spinal rod. In effect, the results of biomechanical modeling might not be so realistic and the corrective forces during the surgical correction procedure were intra-operatively difficult to measure. Projective geometry has been shown to be successful in the reconstruction of a three-dimensional structure using a series of images obtained from different views. In this study, we propose a new method to measure the three-dimensional geometry of an implant rod using two cameras. The reconstruction method requires only a few parameters, the included angle θ between the two cameras, the actual length of the rod in mm, and the location of points for curve fitting. The implant rod utilized in spine surgery was used to evaluate the accuracy of the current method. The three-dimensional geometry of the rod was measured from the image obtained by a scanner and compared to the proposed method using two cameras. The mean error in the reconstruction measurements ranged from 0.32 to 0.45 mm. The method presented here demonstrated the possibility of intra-operatively measuring the three-dimensional geometry of spinal rod. The proposed method could be used in surgical procedures to better understand the biomechanics of scoliosis correction through real-time measurement of three-dimensional implant rod geometry in vivo.
SU-E-CAMPUS-T-02: Exploring Radiation Acoustics CT Dosimeter Design Aspects for Proton Therapy
DOE Office of Scientific and Technical Information (OSTI.GOV)
Alsanea, F; Moskvin, V; Stantz, K
2014-06-15
Purpose: Investigate the design aspects and imaging dose capabilities of the Radiation Acoustics Computed Tomography (RA CT) dosimeter for Proton induced acoustics, with the objective to characterize a pulsed pencil proton beam. The focus includes scanner geometry, transducer array, and transducer bandwidth on image quality. Methods: The geometry of the dosimeter is a cylindrical water phantom (length 40cm, radius 15cm) with 71 ultrasound transducers placed along the length and end of the cylinder to achieve a weighted set of projections with spherical sampling. A 3D filtered backprojection algorithm was used to reconstruct the dosimetric images and compared to MC dosemore » distribution. First, 3D Monte Carlo (MC) Dose distributions for proton beam energies (range of 12cm, 16cm, 20cm, and 27cm) were used to simulate the acoustic pressure signal within this scanner for a pulsed proton beam of 1.8x107 protons, with a pulse width of 1 microsecond and a rise time of 0.1 microseconds. Dose comparison within the Bragg peak and distal edge were compared to MC analysis, where the integrated Gaussian was used to locate the 50% dose of the distal edge. To evaluate spatial fidelity, a set of point sources within the scanner field of view (15×15×15cm3) were simulated implementing a low-pass bandwidth response function (0 to 1MHz) equivalent to a multiple frequency transducer array, and the FWHM of the point-spread-function determined. Results: From the reconstructed images, RACT and MC range values are within 0.5mm, and the average variation of the dose within the Bragg peak are within 2%. The spatial resolution tracked with transducer bandwidth and projection angle sampling, and can be kept at 1.5mm. Conclusion: This design is ready for fabrication to start acquiring measurements. The 15 cm FOV is an optimum size for imaging dosimetry. Currently, simulations comparing transducer sensitivity, bandwidth, and proton beam parameters are being evaluated to assess signal-to-noise.« less
Strongly-Refractive One-Dimensional Photonic Crystal Prisms
NASA Technical Reports Server (NTRS)
Ting, David Z. (Inventor)
2004-01-01
One-dimensional (1D) photonic crystal prisms can separate a beam of polychromatic electromagnetic waves into constituent wavelength components and can utilize unconventional refraction properties for wavelength dispersion over significant portions of an entire photonic band rather than just near the band edges outside the photonic band gaps. Using a ID photonic crystal simplifies the design and fabrication process and allows the use of larger feature sizes. The prism geometry broadens the useful wavelength range, enables better optical transmission, and exhibits angular dependence on wavelength with reduced non-linearity. The properties of the 1 D photonic crystal prism can be tuned by varying design parameters such as incidence angle, exit surface angle, and layer widths. The ID photonic crystal prism can be fabricated in a planar process, and can be used as optical integrated circuit elements.
Greco, Cristina; Marini, Alberto; Frezza, Elisa; Ferrarini, Alberta
2014-05-19
We present a computational investigation of the nematic phase of the bent-core liquid crystal A131. We use an integrated approach that bridges density functional theory calculations of molecular geometry and torsional potentials to elastic properties through the molecular conformational and orientational distribution function. This unique capability to simultaneously access different length scales enables us to consistently describe molecular and material properties. We can reassign (13)C NMR chemical shifts and analyze the dependence of phase properties on molecular shape. Focusing on the elastic constants we can draw some general conclusions on the unconventional behavior of bent-core nematics and highlight the crucial role of a properly-bent shape. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
TetrUSS Capabilities for S and C Applications
NASA Technical Reports Server (NTRS)
Frink, Neal T.; Parikh, Paresh
2004-01-01
TetrUSS is a suite of loosely coupled computational fluid dynamics software that is packaged into a complete flow analysis system. The system components consist of tools for geometry setup, grid generation, flow solution, visualization, and various utilities tools. Development began in 1990 and it has evolved into a proven and stable system for Euler and Navier-Stokes analysis and design of unconventional configurations. It is 1) well developed and validated, 2) has a broad base of support, and 3) is presently is a workhorse code because of the level of confidence that has been established through wide use. The entire system can now run on linux or mac architectures. In the following slides, I will highlight more of the features of the VGRID and USM3D codes.
Unconventional shallow biogenic gas systems
Shurr, G.W.; Ridgley, J.L.
2002-01-01
Unconventional shallow biogenic gas falls into two distinct systems that have different attributes. Early-generation systems have blanketlike geometries, and gas generation begins soon after deposition of reservoir and source rocks. Late-generation systems have ringlike geometries, and long time intervals separate deposition of reservoir and source rocks from gas generation. For both types of systems, the gas is dominantly methane and is associated with source rocks that are not thermally mature. Early-generation biogenic gas systems are typified by production from low-permeability Cretaceous rocks in the northern Great Plains of Alberta, Saskatchewan, and Montana. The main area of production is on the southeastern margin of the Alberta basin and the northwestern margin of the Williston basin. The huge volume of Cretaceous rocks has a generalized regional pattern of thick, non-marine, coarse clastics to the west and thinner, finer grained marine lithologies to the east. Reservoir rocks in the lower part tend to be finer grained and have lower porosity and permeability than those in the upper part. Similarly, source beds in the units have higher values of total organic carbon. Patterns of erosion, deposition, deformation, and production in both the upper and lower units are related to the geometry of lineament-bounded basement blocks. Geochemical studies show that gas and coproduced water are in equilibrium and that the fluids are relatively old, namely, as much as 66 Ma. Other examples of early-generation systems include Cretaceous clastic reservoirs on the southwestern margin of Williston basin and chalks on the eastern margin of the Denver basin. Late-generation biogenic gas systems have as an archetype the Devonian Antrim Shale on the northern margin of the Michigan basin. Reservoir rocks are fractured, organic-rich black shales that also serve as source rocks. Although fractures are important for production, the relationships to specific geologic structures are not clear. Large quantities of water are coproduced with the gas, and geochemical data indicate that the water is fairly fresh and relatively young. Current thinking holds that biogenic gas was generated, and perhaps continues to be, when glacial meltwater descended into the plumbing system provided by fractures. Other examples of late-generation systems include the Devonian New Albany Shale on the eastern margin of the Illinois basin and the Tertiary coalbed methane production on the northwestern margin of the Powder River basin. Both types of biogenic gas systems have a similar resource development history. Initially, little technology is used, and gas is consumed locally; eventually, sweet spots are exploited, widespread unconventional reservoirs are developed, and transport of gas is interstate or international. However, drilling and completion techniques are very different between the two types of systems. Early-generation systems have water-sensitive reservoir rocks, and consequently water is avoided or minimized in drilling and completion. In contrast, water is an important constituent of late-generation systems; gas production is closely tied to dewatering the system during production. Existing production and resource estimates generally range from 10 to 100 tcf for both types of biogenic gas systems. Although both system types are examples of relatively continuous accumulations, the geologic frameworks constrain most-economic production to large geologic structures on the margins of basins. Shallow biogenic gas systems hold important resources to meet the increased domestic and international demands for natural gas.
Point Cloud Management Through the Realization of the Intelligent Cloud Viewer Software
NASA Astrophysics Data System (ADS)
Costantino, D.; Angelini, M. G.; Settembrini, F.
2017-05-01
The paper presents a software dedicated to the elaboration of point clouds, called Intelligent Cloud Viewer (ICV), made in-house by AESEI software (Spin-Off of Politecnico di Bari), allowing to view point cloud of several tens of millions of points, also on of "no" very high performance systems. The elaborations are carried out on the whole point cloud and managed by means of the display only part of it in order to speed up rendering. It is designed for 64-bit Windows and is fully written in C ++ and integrates different specialized modules for computer graphics (Open Inventor by SGI, Silicon Graphics Inc), maths (BLAS, EIGEN), computational geometry (CGAL, Computational Geometry Algorithms Library), registration and advanced algorithms for point clouds (PCL, Point Cloud Library), advanced data structures (BOOST, Basic Object Oriented Supporting Tools), etc. ICV incorporates a number of features such as, for example, cropping, transformation and georeferencing, matching, registration, decimation, sections, distances calculation between clouds, etc. It has been tested on photographic and TLS (Terrestrial Laser Scanner) data, obtaining satisfactory results. The potentialities of the software have been tested by carrying out the photogrammetric survey of the Castel del Monte which was already available in previous laser scanner survey made from the ground by the same authors. For the aerophotogrammetric survey has been adopted a flight height of approximately 1000ft AGL (Above Ground Level) and, overall, have been acquired over 800 photos in just over 15 minutes, with a covering not less than 80%, the planned speed of about 90 knots.
NASA Astrophysics Data System (ADS)
Ceriotti, Matteo
The idea of exploiting solar radiation pressure for space travel, or solar sailing, is more than a 100 years old, and yet most of the research thus far has considered only a limited number of sail configurations. However solar sails do not have to be inertially-pointing squares, spin-stabilised discs or heliogyros: there is a range of different configurations and concepts that present some advantageous features. This chapter will show and discuss three non-conventional solar sail configurations and their applications. In the first, the sail is complemented by an electric thruster, resulting in a hybrid-propulsion spacecraft which is capable to hover above the Earth's Poles in a stationary position (pole-sitter). The second concept makes use of a variable-geometry pyramidal sail, naturally pointing towards the sun, to increase or decrease the orbit altitude without the need of propellant or attitude manoeuvres. Finally, the third concept shows that the orbit altitude can also be changed, without active manoeuvres or geometry change, if the sail naturally oscillates synchronously with the orbital motion. The main motivation behind these novel configurations is to overcome some of the engineering limitations of solar sailing; the resulting concepts pose some intriguing orbital and attitude dynamics problems, which will be discussed.
High-Fidelity Multidisciplinary Design Optimization of Aircraft Configurations
NASA Technical Reports Server (NTRS)
Martins, Joaquim R. R. A.; Kenway, Gaetan K. W.; Burdette, David; Jonsson, Eirikur; Kennedy, Graeme J.
2017-01-01
To evaluate new airframe technologies we need design tools based on high-fidelity models that consider multidisciplinary interactions early in the design process. The overarching goal of this NRA is to develop tools that enable high-fidelity multidisciplinary design optimization of aircraft configurations, and to apply these tools to the design of high aspect ratio flexible wings. We develop a geometry engine that is capable of quickly generating conventional and unconventional aircraft configurations including the internal structure. This geometry engine features adjoint derivative computation for efficient gradient-based optimization. We also added overset capability to a computational fluid dynamics solver, complete with an adjoint implementation and semiautomatic mesh generation. We also developed an approach to constraining buffet and started the development of an approach for constraining utter. On the applications side, we developed a new common high-fidelity model for aeroelastic studies of high aspect ratio wings. We performed optimal design trade-o s between fuel burn and aircraft weight for metal, conventional composite, and carbon nanotube composite wings. We also assessed a continuous morphing trailing edge technology applied to high aspect ratio wings. This research resulted in the publication of 26 manuscripts so far, and the developed methodologies were used in two other NRAs. 1
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kocharian, Armen N.; Fernando, Gayanath W.; Fang, Kun
Rashba spin-orbit effects and electron correlations in the two-dimensional cylindrical lattices of square geometries are assessed using mesoscopic two-, three- and four-leg ladder structures. Here the electron transport properties are systematically calculated by including the spin-orbit coupling in tight binding and Hubbard models threaded by a magnetic flux. These results highlight important aspects of possible symmetry breaking mechanisms in square ladder geometries driven by the combined effect of a magnetic gauge field spin-orbit interaction and temperature. The observed persistent current, spin and charge polarizations in the presence of spin-orbit coupling are driven by separation of electron and hole charges andmore » opposite spins in real-space. The modeled spin-flip processes on the pairing mechanism induced by the spin-orbit coupling in assembled nanostructures (as arrays of clusters) engineered in various two-dimensional multi-leg structures provide an ideal playground for understanding spatial charge and spin density inhomogeneities leading to electron pairing and spontaneous phase separation instabilities in unconventional superconductors. Such studies also fall under the scope of current challenging problems in superconductivity and magnetism, topological insulators and spin dependent transport associated with numerous interfaces and heterostructures.« less
Enhanced PET resolution by combining pinhole collimation and coincidence detection
NASA Astrophysics Data System (ADS)
DiFilippo, Frank P.
2015-10-01
Spatial resolution of clinical PET scanners is limited by detector design and photon non-colinearity. Although dedicated small animal PET scanners using specialized high-resolution detectors have been developed, enhancing the spatial resolution of clinical PET scanners is of interest as a more available alternative. Multi-pinhole 511 keV SPECT is capable of high spatial resolution but requires heavily shielded collimators to avoid significant background counts. A practical approach with clinical PET detectors is to combine multi-pinhole collimation with coincidence detection. In this new hybrid modality, there are three locations associated with each event, namely those of the two detected photons and the pinhole aperture. These three locations over-determine the line of response and provide redundant information that is superior to coincidence detection or pinhole collimation alone. Multi-pinhole collimation provides high resolution and avoids non-colinearity error but is subject to collimator penetration and artifacts from overlapping projections. However the coincidence information, though at lower resolution, is valuable for determining whether the photon passed near a pinhole within the cone acceptance angle and for identifying through which pinhole the photon passed. This information allows most photons penetrating through the collimator to be rejected and avoids overlapping projections. With much improved event rejection, a collimator with minimal shielding may be used, and a lightweight add-on collimator for high resolution imaging is feasible for use with a clinical PET scanner. Monte Carlo simulations were performed of a 18F hot rods phantom and a 54-pinhole unfocused whole-body mouse collimator with a clinical PET scanner. Based on coincidence information and pinhole geometry, events were accepted or rejected, and pinhole-specific crystal-map projections were generated. Tomographic images then were reconstructed using a conventional pinhole SPECT algorithm. Hot rods of 1.4 mm diameter were resolved easily in a simulated phantom. System sensitivity was 0.09% for a simulated 70-mm line source corresponding to the NEMA NU-4 mouse phantom. Higher resolution is expected with further optimization of pinhole design, and higher sensitivity is expected with a focused and denser pinhole configuration. The simulations demonstrate high spatial resolution and feasibility of small animal imaging with an add-on multi-pinhole collimator for a clinical PET scanner. Further work is needed to develop geometric calibration and quantitative data corrections and, eventually, to construct a prototype device and produce images with physical phantoms.
Unconventional Word Segmentation in Emerging Bilingual Students' Writing: A Longitudinal Analysis
ERIC Educational Resources Information Center
Sparrow, Wendy
2014-01-01
This study explores cross-language and longitudinal patterns in unconventional word segmentation in 25 emerging bilingual students' (Spanish/English) writing from first through third grade. Spanish and English writing samples were collected annually and analyzed for two basic types of unconventional word segmentation: hyposegmentation, in…
ERIC Educational Resources Information Center
Andreas, Stuart F. K.; Zech, Stefan; Coyle, Thomas R.; Rindermann, Heiner
2016-01-01
Creativity is negatively associated with certain personality traits (e.g., conformity) and social influences (e.g., group pressure). In this study, creativity was examined in relation to unconventionality, which was expected to correlate positively with creativity, especially originality. This hypothesis was based on the theory that unconventional…
Geology and assessment of unconventional oil and gas resources of northeastern Mexico
,
2015-01-01
The U.S. Geological Survey, in cooperation with the U.S. Department of State, quantitatively assessed the potential for unconventional oil and gas resources within the onshore portions of the Tampico-Misantla Basin, Burgos Basin, and Sabinas Basin provinces of northeastern Mexico. Unconventional resources of the Veracruz Basin were not quantitatively assessed because of a current lack of required geological information. Unconventional resources include shale gas, shale oil, tight gas, tight oil, and coalbed gas. Undiscovered conventional oil and gas resources were assessed in Mexico in 2012.
Bowen, Zachary H.; Oelsner, Gretchen P.; Cade, Brian S.; Gallegos, Tanya J.; Farag, Aïda M.; Mott, David N.; Potter, Christopher J.; Cinotto, Peter J.; Clark, Melanie L.; Kappel, William M.; Kresse, Timothy M.; Melcher, Cynthia P.; Paschke, Suzanne; Susong, David D.; Varela, Brian A.
2015-01-01
Heightened concern regarding the potential effects of unconventional oil and gas development on regional water quality has emerged, but the few studies on this topic are limited in geographic scope. Here we evaluate the potential utility of national and publicly available water-quality data sets for addressing questions regarding unconventional oil and gas development. We used existing U.S. Geological Survey and U.S. Environmental Protection Agency data sets to increase understanding of the spatial distribution of unconventional oil and gas development in the U.S. and broadly assess surface water quality trends in these areas. Based on sample size limitations, we were able to estimate trends in specific conductance (SC) and chloride (Cl-) from 1970 to 2010 in 16% (n=155) of the watersheds with unconventional oil and gas resources. We assessed these trends relative to spatiotemporal distributions of hydraulically fractured wells. Results from this limited analysis suggest no consistent and widespread trends in surface water quality for SC and Cl- in areas with increasing unconventional oil and gas development and highlight limitations of existing national databases for addressing questions regarding unconventional oil and gas development and water quality.
Permeability Evolution With Shearing of Simulated Faults in Unconventional Shale Reservoirs
NASA Astrophysics Data System (ADS)
Wu, W.; Gensterblum, Y.; Reece, J. S.; Zoback, M. D.
2016-12-01
Horizontal drilling and multi-stage hydraulic fracturing can lead to fault reactivation, a process thought to influence production from extremely low-permeability unconventional reservoir. A fundamental understanding of permeability changes with shear could be helpful for optimizing reservoir stimulation strategies. We examined the effects of confining pressure and frictional sliding on fault permeability in Eagle Ford shale samples. We performed shear-flow experiments in a triaxial apparatus on four shale samples: (1) clay-rich sample with sawcut fault, (2) calcite-rich sample with sawcut fault, (3) clay-rich sample with natural fault, and (4) calcite-rich sample with natural fault. We used pressure pulse-decay and steady-state flow techniques to measure fault permeability. Initial pore and confining pressures are set to 2.5 MPa and 5.0 MPa, respectively. To investigate the influence of confining pressure on fault permeability, we incrementally raised and lowered the confining pressure and measure permeability at different effective stresses. To examine the effect of frictional sliding on fault permeability, we slide the samples four times at a constant shear displacement rate of 0.043 mm/min for 10 minutes each and measure fault permeability before and after frictional sliding. We used a 3D Laser Scanner to image fault surface topography before and after the experiment. Our results show that frictional sliding can enhance fault permeability at low confining pressures (e.g., ≥5.0 MPa) and reduce fault permeability at high confining pressures (e.g., ≥7.5 MPa). The permeability of sawcut faults almost fully recovers when confining pressure returns to the initial value, and increases with sliding due to asperity damage and subsequent dilation at low confining pressures. In contrast, the permeability of natural faults does not fully recover. It initially increases with sliding, but then decreases with further sliding most likely due to fault gouge blocking fluid pathways.
NASA Astrophysics Data System (ADS)
Ning, Li; Shicheng, Zhang; Yushi, Zou; Xinfang, Ma; Shan, Wu; Yinuo, Zhang
2018-04-01
Microseismic/acoustic emission (AE) monitoring is an essential technology for understanding hydraulic fracture (HF) geometry and stimulated reservoir volume (SRV) during hydraulic fracturing in unconventional reservoirs. To investigate HF growth mechanisms and features of induced microseismic/AE events in a layered formation, laboratory fracturing experiments were performed on shale specimens (30 cm × 30 cm × 30 cm) with multiple bedding planes (BPs) under triaxial stresses. AE monitoring was used to reveal the spatial distribution and hypocenter mechanisms of AE events induced by rock failure. Computerized tomography scanning was used to observe the internal fracture geometry. Experimental results showed that the various HF geometries could be obviously distinguished based on injection pressure curves and AE responses. Fracture complexity was notably increased when vertically growing HFs connected with and opened more BPs. The formation of a complex fracture network was generally indicated by frequent fluctuations in injection pressure curves, intense AE activity, and three-dimensionally distributed AE events. Investigations of the hypocenter mechanisms revealed that shear failure/event dominated in shale specimens. Shear and tensile events were induced in hydraulically connected regions, and shear events also occurred around BPs that were not hydraulically connected. This led to an overestimation of HF height and SRV in layered formations based on the AE location results. The results also showed that variable injection rate and using plugging agent were conducive in promoting HF to penetrate through the weak and high-permeability BPs, thereby increasing the fracture height.
Assessment of unconventional oil and gas resources in Northeast Mexico, 2014
Schenk, Christopher J.; Charpentier, Ronald R.; Klett, Timothy R.; Tennyson, Marilyn E.; Gaswirth, Stephanie B.; Brownfield, Michael E.; Pawlewicz, Mark J.; Weaver, Jean Noe
2014-01-01
Using a geology-based assessment methodology, the U.S. Geological Survey estimated means of 0.78 billion barrels of unconventional oil, 23.5 trillion cubic feet of unconventional gas, and 0.88 billion barrels of natural gas liquids in the Sabinas Basin, Burgos Basin, and Tampico-Misantla Basin provinces of northeast Mexico.
Unconventional superconductivity in heavy-fermion compounds
White, B. D.; Thompson, J. D.; Maple, M. B.
2015-02-27
Over the past 35 years, research on unconventional superconductivity in heavy-fermion systems has evolved from the surprising observations of unprecedented superconducting properties in compounds that convention dictated should not superconduct at all to performing explorations of rich phase spaces in which the delicate interplay between competing ground states appears to support emergent superconducting states. In this article, we review the current understanding of superconductivity in heavy-fermion com- pounds and identify a set of characteristics that is common to their unconventional superconducting states. These core properties are compared with those of other classes of unconventional superconductors such as the cuprates andmore » iron-based superconductors. Lastly, we conclude by speculating on the prospects for future research in this field and how new advances might contribute towards resolving the long-standing mystery of how unconventional superconductivity works.« less
NASA Astrophysics Data System (ADS)
Ahmed, Abdella M.; Tashima, Hideaki; Yoshida, Eiji; Nishikido, Fumihiko; Yamaya, Taiga
2017-06-01
There is a growing interest in developing brain PET scanners with high sensitivity and high spatial resolution for early diagnosis of neurodegenerative diseases and studies of brain functions. Sensitivity of the PET scanner can be improved by increasing the solid angle. However, conventional PET scanners are designed based on a cylindrical geometry, which may not be the most efficient design for brain imaging in terms of the balance between sensitivity and cost. We proposed a dedicated brain PET scanner based on a hemispheric shape detector and a chin detector (referred to as the helmet-chin PET), which is designed to maximize the solid angle by increasing the number of lines-of-response in the hemisphere. The parallax error, which PET scanners with a large solid angle tend to have, can be suppressed by the use of depth-of-interaction detectors. In this study, we carry out a realistic evaluation of the helmet-chin PET using Monte Carlo simulation based on the 4-layer GSO detector which consists of a 16 × 16 × 4 array of crystals with dimensions of 2.8 × 2.8 × 7.5 mm3. The purpose of this simulation is to show the gain in imaging performance of the helmet-chin PET compared with the cylindrical PET using the same number of detectors in each configuration. The sensitivity of the helmet-chin PET evaluated with a cylindrical phantom has a significant increase, especially at the top of the (field-of-view) FOV. The peak-NECR of the helmet-chin PET is 1.4 times higher compared to the cylindrical PET. The helmet-chin PET provides relatively low noise images throughout the FOV compared to the cylindrical PET which exhibits enhanced noise at the peripheral regions. The results show the helmet-chin PET can significantly improve the sensitivity and reduce the noise in the reconstructed images.
Baumrind, S; Carlson, S; Beers, A; Curry, S; Norris, K; Boyd, R L
2003-01-01
Past research in integrated three-dimensional (3D) craniofacial mapping at the Craniofacial Research Instrumentation Laboratory (CRIL) of the University of the Pacific is summarized in narrative form. The advantages and limitations of recent commercial developments in the application of cone beam geometry volumetric X-ray scanners in dentistry and surface digital mapping of study casts are discussed. The rationale for methods currently in development at CRIL for merging longitudinal information from existing 3D study casts and two-dimensional lateral X-ray cephalograms in studies of orthodontic treatment outcome is presented.
Fan-beam scanning laser optical computed tomography for large volume dosimetry
NASA Astrophysics Data System (ADS)
Dekker, K. H.; Battista, J. J.; Jordan, K. J.
2017-05-01
A prototype scanning-laser fan beam optical CT scanner is reported which is capable of high resolution, large volume dosimetry with reasonable scan time. An acylindrical, asymmetric aquarium design is presented which serves to 1) generate parallel-beam scan geometry, 2) focus light towards a small acceptance angle detector, and 3) avoid interference fringe-related artifacts. Preliminary experiments with uniform solution phantoms (11 and 15 cm diameter) and finger phantoms (13.5 mm diameter FEP tubing) demonstrate that the design allows accurate optical CT imaging, with optical CT measurements agreeing within 3% of independent Beer-Lambert law calculations.
Carbon dioxide storage in unconventional reservoirs workshop: summary of recommendations
Jones, Kevin B.; Blondes, Madalyn S.
2015-01-01
The storage capacity for all unconventional reservoirs may be modeled using a volumetric equation starting with the extent of the rock unit and adjusted using these key factors and reaction terms. The ideas that were developed during this workshop can be used by USGS scientists to develop a methodology to assess the CO2 storage resource in unconventional reservoirs. This methodology could then be released for public comment and peer review. After completing this development process, the USGS could then use the methodology to assess the CO2 storage resource in unconventional reservoirs.
The Influence of Gantry Geometry on Aliasing and Other Geometry Dependent Errors
NASA Astrophysics Data System (ADS)
Joseph, Peter M.
1980-06-01
At least three gantry geometries are widely used in medical CT scanners: (1) rotate-translate, (2) rotating detectors, (3) stationary detectors. There are significant geometrical differences between these designs, especially regarding (a) the region of space scanned by any given detector and (b) the sample density of rays which scan the patient. It is imperative to distinguish between "views" and "rays" in analyzing this situation. In particular, views are defined by the x-ray source in type 2 and by the detector in type 3 gantries. It is known that ray dependent errors are generally much more important than view dependent errors. It is shown that spatial resolution is primarily limited by the spacing between rays in any view, while the number of ray samples per beam width determines the extent of aliasing artifacts. Rotating detector gantries are especially susceptible to aliasing effects. It is shown that aliasing effects can distort the point spread function in a way that is highly dependent on the position of the point in the scanned field. Such effects can cause anomalies in the MTF functions as derived from points in machines with significant aliasing problems.
A Comparison of Ultrasound Tomography Methods in Circular Geometry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Leach, R R; Azevedo, S G; Berryman, J G
2002-01-24
Extremely high quality data was acquired using an experimental ultrasound scanner developed at Lawrence Livermore National Laboratory using a 2D ring geometry with up to 720 transmitter/receiver transducer positions. This unique geometry allows reflection and transmission modes and transmission imaging and quantification of a 3D volume using 2D slice data. Standard image reconstruction methods were applied to the data including straight-ray filtered back projection, reflection tomography, and diffraction tomography. Newer approaches were also tested such as full wave, full wave adjoint method, bent-ray filtered back projection, and full-aperture tomography. A variety of data sets were collected including a formalin-fixed humanmore » breast tissue sample, a commercial ultrasound complex breast phantom, and cylindrical objects with and without inclusions. The resulting reconstruction quality of the images ranges from poor to excellent. The method and results of this study are described including like-data reconstructions produced by different algorithms with side-by-side image comparisons. Comparisons to medical B-scan and x-ray CT scan images are also shown. Reconstruction methods with respect to image quality using resolution, noise, and quantitative accuracy, and computational efficiency metrics will also be discussed.« less
Schaefer, Donald H.; Welch, Alan H.; Mauzer, Douglas K.
1983-01-01
Studies of the geothermal potential of the western arm of the Black Rock Desert in northwestern Nevada included a compilation of existing geologic data on a detailed map, a temperature survey at 1-meter depth, a thermal-scanner survey, and gravity and seismic surveys to determine basin geometry. The temperature survey showed the effects of heating at shallow depths due to rising geothermal fluids near the known hot spring areas. Lower temperatures were noted in areas of probable near-surface ground-water movement. The thermal-scanner survey verified the known geothermal areas and showed relatively high-temperature areas of standing water and ground-water discharge. The upland areas of the desert were found to be distinctly warmer than the playa area, probably due to low thermal diffusivity resulting from low moisture content. The surface geophysical surveys indicated that the maximum thickness of valley-fill deposits in the desert is about 3,200 meters. Gravity data further showed that changes in the trend of the desert axis occurred near thermal areas. (USGS)
NASA Astrophysics Data System (ADS)
David, Sabrina; Burion, Steve; Tepe, Alan; Wilfley, Brian; Menig, Daniel; Funk, Tobias
2012-03-01
Iterative reconstruction methods have emerged as a promising avenue to reduce dose in CT imaging. Another, perhaps less well-known, advance has been the development of inverse geometry CT (IGCT) imaging systems, which can significantly reduce the radiation dose delivered to a patient during a CT scan compared to conventional CT systems. Here we show that IGCT data can be reconstructed using iterative methods, thereby combining two novel methods for CT dose reduction. A prototype IGCT scanner was developed using a scanning beam digital X-ray system - an inverse geometry fluoroscopy system with a 9,000 focal spot x-ray source and small photon counting detector. 90 fluoroscopic projections or "superviews" spanning an angle of 360 degrees were acquired of an anthropomorphic phantom mimicking a 1 year-old boy. The superviews were reconstructed with a custom iterative reconstruction algorithm, based on the maximum-likelihood algorithm for transmission tomography (ML-TR). The normalization term was calculated based on flat-field data acquired without a phantom. 15 subsets were used, and a total of 10 complete iterations were performed. Initial reconstructed images showed faithful reconstruction of anatomical details. Good edge resolution and good contrast-to-noise properties were observed. Overall, ML-TR reconstruction of IGCT data collected by a bench-top prototype was shown to be viable, which may be an important milestone in the further development of inverse geometry CT.
Geology and assessment of unconventional resources of Phitsanulok Basin, Thailand
,
2014-01-01
The U.S. Geological Survey (USGS) quantitatively assessed the potential for unconventional oil and gas resources within the Phitsanulok Basin of Thailand. Unconventional resources for the USGS include shale gas, shale oil, tight gas, tight oil, and coalbed gas. In the Phitsanulok Basin, only potential shale-oil and shale-gas resources were quantitatively assessed.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rit, Simon, E-mail: simon.rit@creatis.insa-lyon.fr; Clackdoyle, Rolf; Keuschnigg, Peter
Purpose: A new cone-beam CT scanner for image-guided radiotherapy (IGRT) can independently rotate the source and the detector along circular trajectories. Existing reconstruction algorithms are not suitable for this scanning geometry. The authors propose and evaluate a three-dimensional (3D) filtered-backprojection reconstruction for this situation. Methods: The source and the detector trajectories are tuned to image a field-of-view (FOV) that is offset with respect to the center-of-rotation. The new reconstruction formula is derived from the Feldkamp algorithm and results in a similar three-step algorithm: projection weighting, ramp filtering, and weighted backprojection. Simulations of a Shepp Logan digital phantom were used tomore » evaluate the new algorithm with a 10 cm-offset FOV. A real cone-beam CT image with an 8.5 cm-offset FOV was also obtained from projections of an anthropomorphic head phantom. Results: The quality of the cone-beam CT images reconstructed using the new algorithm was similar to those using the Feldkamp algorithm which is used in conventional cone-beam CT. The real image of the head phantom exhibited comparable image quality to that of existing systems. Conclusions: The authors have proposed a 3D filtered-backprojection reconstruction for scanners with independent source and detector rotations that is practical and effective. This algorithm forms the basis for exploiting the scanner’s unique capabilities in IGRT protocols.« less
NASA Astrophysics Data System (ADS)
Chatzimavroudis, George P.; Spirka, Thomas A.; Setser, Randolph M.; Myers, Jerry G.
2005-04-01
One of NASA"s objectives is to be able to perform a complete pre-flight evaluation of possible cardiovascular changes in astronauts scheduled for prolonged space missions. Blood flow is an important component of cardiovascular function. Lately, attention has focused on using computational fluid dynamics (CFD) to analyze flow with realistic vessel geometries. MRI can provide detailed geometrical information and is the only clinical technique to measure all three spatial velocity components. The objective of this study was to investigate the reliability of MRI-based model reconstruction for CFD simulations. An aortic arch model and a carotid bifurcation model were scanned in a 1.5T MRI scanner. Axial MRI acquisitions provided images for geometry reconstruction using different resolution settings. The vessel walls were identified and the geometry was reconstructed using existing software. The geometry was then imported into a commercial CFD package for meshing and numerical solution. MRI velocity acquisitions provided true inlet boundary conditions for steady flow, as well as three-directional velocity data at several locations. In addition, an idealized version of each geometry was created from the model drawings. Contour and vector plots of the velocity showed identical features between the MRI velocity data, the MRI-based CFD data, and the idealized-geometry CFD data, with mean differences <10%. CFD results from different MRI resolution settings did not show significant differences (<5%). This study showed quantitatively that reliable CFD simulations can be performed in models reconstructed from MRI acquisitions and gives evidence that a future, subject-specific, computational evaluation of the cardiovascular system is possible.
Multiorbital kinetic effects on charge ordering of frustrated electrons on the triangular lattice
NASA Astrophysics Data System (ADS)
Février, C.; Fratini, S.; Ralko, A.
2015-06-01
The role of the multiorbital effects on the emergence of frustrated electronic orders on the triangular lattice at half filling is investigated through an extended spinless fermion Hubbard model. By using two complementary approaches, unrestricted Hartree-Fock and exact diagonalizations, we unravel a very rich phase diagram controlled by the strength of both local and off-site Coulomb interactions and by the interorbital hopping anisotropy ratio t'/t . Three robust unconventional electronic phases, a pinball liquid, an inverse pinball liquid, and a large-unit-cell √{12 }×√{12 } droplet phase, are found to be generic in the triangular geometry, being controlled by the band structure parameters. The latter are also stabilized in the isotropic limit of our microscopic model, which recovers the standard SU(2) spinful extended single-band Hubbard model.
Study of unconventional propulsion system concepts for use in a long range transport
NASA Technical Reports Server (NTRS)
Champagne, G. A.
1973-01-01
The noise level of an uncoventional propulsion system for the next generation of subsonic, long-range transport aircraft is discussed. The desired noise level may be achieved by: (1) a fixed geometry, high bypass ratio turbofan with a geared two-stage fan and advanced acoustic treatment or (2) a moderate bypass ratio turbofan with a variable pitch two-stage fan, variable primary and duct nozzles, and advanced acoustic treatment. The geared fan system meets the noise goal with minimum economic penalty. Comparison of the noise levels at takeoff and landing in combination with the economic penalties required to achieve the lower noise levels at specific noise measuring stations, indicate that both area reduction and current certification prodedures should be used to ascertain the point of diminishing returns in establishing future noise goals.
Emergence of an enslaved phononic bandgap in a non-equilibrium pseudo-crystal.
Bachelard, Nicolas; Ropp, Chad; Dubois, Marc; Zhao, Rongkuo; Wang, Yuan; Zhang, Xiang
2017-08-01
Material systems that reside far from thermodynamic equilibrium have the potential to exhibit dynamic properties and behaviours resembling those of living organisms. Here we realize a non-equilibrium material characterized by a bandgap whose edge is enslaved to the wavelength of an external coherent drive. The structure dynamically self-assembles into an unconventional pseudo-crystal geometry that equally distributes momentum across elements. The emergent bandgap is bestowed with lifelike properties, such as the ability to self-heal to perturbations and adapt to sudden changes in the drive. We derive an exact analytical solution for both the spatial organization and the bandgap features, revealing the mechanism for enslavement. This work presents a framework for conceiving lifelike non-equilibrium materials and emphasizes the potential for the dynamic imprinting of material properties through external degrees of freedom.
Emergence of an enslaved phononic bandgap in a non-equilibrium pseudo-crystal
NASA Astrophysics Data System (ADS)
Bachelard, Nicolas; Ropp, Chad; Dubois, Marc; Zhao, Rongkuo; Wang, Yuan; Zhang, Xiang
2017-08-01
Material systems that reside far from thermodynamic equilibrium have the potential to exhibit dynamic properties and behaviours resembling those of living organisms. Here we realize a non-equilibrium material characterized by a bandgap whose edge is enslaved to the wavelength of an external coherent drive. The structure dynamically self-assembles into an unconventional pseudo-crystal geometry that equally distributes momentum across elements. The emergent bandgap is bestowed with lifelike properties, such as the ability to self-heal to perturbations and adapt to sudden changes in the drive. We derive an exact analytical solution for both the spatial organization and the bandgap features, revealing the mechanism for enslavement. This work presents a framework for conceiving lifelike non-equilibrium materials and emphasizes the potential for the dynamic imprinting of material properties through external degrees of freedom.
Topological Acoustic Delay Line
NASA Astrophysics Data System (ADS)
Zhang, Zhiwang; Tian, Ye; Cheng, Ying; Wei, Qi; Liu, Xiaojun; Christensen, Johan
2018-03-01
Topological protected wave engineering in artificially structured media is at the frontier of ongoing metamaterials research that is inspired by quantum mechanics. Acoustic analogues of electronic topological insulators have recently led to a wealth of new opportunities in manipulating sound propagation with strikingly unconventional acoustic edge modes immune to backscattering. Earlier fabrications of topological insulators are characterized by an unreconfigurable geometry and a very narrow frequency response, which severely hinders the exploration and design of useful devices. Here we establish topologically protected sound in reconfigurable phononic crystals that can be switched on and off simply by rotating its three-legged "atoms" without altering the lattice structure. In particular, we engineer robust phase delay defects that take advantage of the ultrabroadband reflection-free sound propagation. Such topological delay lines serve as a paradigm in compact acoustic devices, interconnects, and electroacoustic integrated circuits.
Marcellus Shale Drilling's Impact on the Dairy Industry in Pennsylvania: A Descriptive Report.
Finkel, Madelon L; Selegean, Jane; Hays, Jake; Kondamudi, Nitin
2013-01-01
Unconventional natural gas drilling in Pennsylvania has accelerated over the past five years, and is unlikely to abate soon. Dairy farming is a large component of Pennsylvania's agricultural economy. This study compares milk production, number of cows, and production per cow in counties with significant unconventional drilling activity to that in neighboring counties with less unconventional drilling activity, from 1996 through 2011. Milk production and milk cows decreased in most counties since 1996, with larger decreases occurring from 2007 through 2011 (when unconventional drilling increased substantially) in five counties with the most wells drilled compared to six adjacent counties with fewer than 100 wells drilled. While this descriptive study cannot draw a causal association between well drilling and decline in cows or milk production, given the importance of Pennsylvania's dairy industry and the projected increase in unconventional natural gas drilling, further research to prevent unintended economic and public health consequences is imperative.
The Unconventional Revolution in Exploration Geophysics
NASA Astrophysics Data System (ADS)
House, N. J.
2014-12-01
During the last 25 years, 3D seismic imaging has revolutionized hydrocarbon exploration by delivering an accurate 3 dimensional picture of the subsurface. The image is capable of detecting fluids within the reservoir, and has significantly reduced the risk of locating and developing hydrocarbon deposits. In late 1990s, deregulation of natural gas prices allowed long recognized deposits of natural gas locked in tight rocks be economic. It sparked factory drilling (repeatable high density evenly spaced) wells and hydraulic fracturing that would help unlock the reservoirs. All that was needed was a geologist to determine depths and limits of the reservoir and engineers to drill and complete the wells. If 3D seismic data was available, it might have been used to define both the limits of the field and drilling hazards. Generally the cost and time required to process and interpret 3D Seismic was considered too high to affect the perceived geologic risk of the Factory approach. Completion costs in unconventional reservoirs account for over 50% of the well costs. It's therefore critical to understand the geometry of how the rock is fracturing and determine optimum well spacing to balance the cost of development with the value of the gas or oil being produced. By extending AVO to the pre-stack domain, it's possible to simultaneously invert for Vp, Vs and density. Armed with these three fundamental rock properties that dictate elastic and inelastic rock response, researchers were able to combine those properties to tie directly to how well a rock will respond to hydraulic fracturing, or which rocks contain a higher TOC, or other rock properties that control how a rock responds to seismic waves or hydraulic fracturing. Combining these results allows interpreters to map areas of higher productivity, and identify bypassed reserves. Currently hundreds of different seismic attributes that are generated from 3D seismic data are used to identify the highest productive areas and how to develop them. MicroSeismic mapping has made completion more efficient and safe. While the geophysics involved in unconventional resource development may not be the first thought in the board room, thier data has become an accepted early development tool of successful oil and gas companies.
Urs P. Kreuter; William E. Fox; John A. Tanaka; Kristie A. Maczko; Daniel W. McCollum; John E. Mitchell; Clifford S. Duke; Lori Hidinger
2012-01-01
More diverse sources of energy are needed for countries to progress toward energy independence and to meet future food production needs. The US Task Force on Strategic Unconventional Fuels concluded that to achieve this objective it is essential to develop a domestic unconventional fuels industry. Rangelands, which cover 50% to 70% of the earth's terrestrial...
Interim Report on Interagency National Personnel Recovery Architecture
2003-07-01
adversaries are smart , however, and rather than face our forces on open battlefields, they will seek to use any asymmetric advantage open to them. If...Liaison Officer SARNEG Search and Rescue Numeric Encryption Grid SARPO Search and Rescue Planning Officer SARREQ Search and Rescue Request SARSAT...Unconventional Assisted Recovery UARCC Unconventional Assisted Recovery Coordination Center UARM Unconventional Assisted Recovery Mechanism UART
DOE Office of Scientific and Technical Information (OSTI.GOV)
Xu, J; Sisniega, A; Zbijewski, W
Purpose: To design a dedicated x-ray cone-beam CT (CBCT) system suitable to deployment at the point-of-care and offering reliable detection of acute intracranial hemorrhage (ICH), traumatic brain injury (TBI), stroke, and other head and neck injuries. Methods: A comprehensive task-based image quality model was developed to guide system design and optimization of a prototype head scanner suitable to imaging of acute TBI and ICH. Previously reported models were expanded to include the effects of x-ray scatter correction necessary for detection of low contrast ICH and the contribution of bit depth (digitization noise) to imaging performance. Task-based detectablity index provided themore » objective function for optimization of system geometry, x-ray source, detector type, anti-scatter grid, and technique at 10–25 mGy dose. Optimal characteristics were experimentally validated using a custom head phantom with 50 HU contrast ICH inserts imaged on a CBCT imaging bench allowing variation of system geometry, focal spot size, detector, grid selection, and x-ray technique. Results: The model guided selection of system geometry with a nominal source-detector distance 1100 mm and optimal magnification of 1.50. Focal spot size ∼0.6 mm was sufficient for spatial resolution requirements in ICH detection. Imaging at 90 kVp yielded the best tradeoff between noise and contrast. The model provided quantitation of tradeoffs between flat-panel and CMOS detectors with respect to electronic noise, field of view, and readout speed required for imaging of ICH. An anti-scatter grid was shown to provide modest benefit in conjunction with post-acquisition scatter correction. Images of the head phantom demonstrate visualization of millimeter-scale simulated ICH. Conclusions: Performance consistent with acute TBI and ICH detection is feasible with model-based system design and robust artifact correction in a dedicated head CBCT system. Further improvements can be achieved with incorporation of model-based iterative reconstruction techniques also within the scope of the task-based optimization framework. David Foos and Xiaohui Wang are employees of Carestream Health.« less
Brough, David; Pelegrin, Pablo; Nickel, Walter
2017-10-01
Extracellular proteins with important signalling roles in processes, such as inflammation and angiogenesis, are known to employ unconventional routes of protein secretion. Although mechanisms of unconventional protein secretion are beginning to emerge, the precise molecular details have remained elusive for the majority of cargo proteins secreted by unconventional means. Recent findings suggest that for two examples of unconventionally secreted proteins, interleukin 1β (IL-1β) and fibroblast growth factor 2 (FGF2), the common molecular principle of pore formation may be shared. Under specific experimental conditions, secretion of IL-1β and FGF2 is triggered by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ]-dependent formation of pores across the plasma membrane. However, the underlying mechanisms are different, with FGF2 known to directly interact with PI(4,5)P 2 , whereas in the case of IL-1β secretion, it is proposed that the N-terminal fragment of gasdermin D interacts with PI(4,5)P 2 to form the pore. Thus, although implemented in different ways, these findings suggest that pore formation may be shared by the unconventional secretion mechanisms for FGF2 and IL-1β in at least some cases. In this Opinion article, we discuss the unconventional mechanisms of FGF2 and IL-1β release with a particular emphasis on recent discoveries suggesting the importance of pore formation on the plasma membrane. © 2017. Published by The Company of Biologists Ltd.
NASA Astrophysics Data System (ADS)
Massiot, Cécile; Nicol, Andrew; Townend, John; McNamara, David D.; Garcia-Sellés, David; Conway, Chris E.; Archibald, Garth
2017-07-01
Permeability hosted in andesitic lava flows is dominantly controlled by fracture systems, with geometries that are often poorly constrained. This paper explores the fracture system geometry of an andesitic lava flow formed during its emplacement and cooling over gentle paleo-topography, on the active Ruapehu volcano, New Zealand. The fracture system comprises column-forming and platy fractures within the blocky interior of the lava flow, bounded by autobreccias partially observed at the base and top of the outcrop. We use a terrestrial laser scanner (TLS) dataset to extract column-forming fractures directly from the point-cloud shape over an outcrop area of ∼3090 m2. Fracture processing is validated using manual scanlines and high-resolution panoramic photographs. Column-forming fractures are either steeply or gently dipping with no preferred strike orientation. Geometric analysis of fractures derived from the TLS, in combination with virtual scanlines and trace maps, reveals that: (1) steeply dipping column-forming fracture lengths follow a scale-dependent exponential or log-normal distribution rather than a scale-independent power-law; (2) fracture intensities (combining density and size) vary throughout the blocky zone but have similar mean values up and along the lava flow; and (3) the areal fracture intensity is higher in the autobreccia than in the blocky zone. The inter-connected fracture network has a connected porosity of ∼0.5 % that promote fluid flow vertically and laterally within the blocky zone, and is partially connected to the autobreccias. Autobreccias may act either as lateral permeability connections or barriers in reservoirs, depending on burial and alteration history. A discrete fracture network model generated from these geometrical parameters yields a highly connected fracture network, consistent with outcrop observations.
The beam stop array method to measure object scatter in digital breast tomosynthesis
NASA Astrophysics Data System (ADS)
Lee, Haeng-hwa; Kim, Ye-seul; Park, Hye-Suk; Kim, Hee-Joung; Choi, Jae-Gu; Choi, Young-Wook
2014-03-01
Scattered radiation is inevitably generated in the object. The distribution of the scattered radiation is influenced by object thickness, filed size, object-to-detector distance, and primary energy. One of the investigations to measure scatter intensities involves measuring the signal detected under the shadow of the lead discs of a beam-stop array (BSA). The measured scatter by BSA includes not only the scattered radiation within the object (object scatter), but also the external scatter source. The components of external scatter source include the X-ray tube, detector, collimator, x-ray filter, and BSA. Excluding background scattered radiation can be applied to different scanner geometry by simple parameter adjustments without prior knowledge of the scanned object. In this study, a method using BSA to differentiate scatter in phantom (object scatter) from external background was used. Furthermore, this method was applied to BSA algorithm to correct the object scatter. In order to confirm background scattered radiation, we obtained the scatter profiles and scatter fraction (SF) profiles in the directions perpendicular to the chest wall edge (CWE) with and without scattering material. The scatter profiles with and without the scattering material were similar in the region between 127 mm and 228 mm from chest wall. This result indicated that the measured scatter by BSA included background scatter. Moreover, the BSA algorithm with the proposed method could correct the object scatter because the total radiation profiles of object scatter correction corresponded to original image in the region between 127 mm and 228 mm from chest wall. As a result, the BSA method to measure object scatter could be used to remove background scatter. This method could apply for different scanner geometry after background scatter correction. In conclusion, the BSA algorithm with the proposed method is effective to correct object scatter.
Eddy current simulation in thick cylinders of finite length induced by coils of arbitrary geometry.
Sanchez Lopez, Hector; Poole, Michael; Crozier, Stuart
2010-12-01
Eddy currents are inevitably induced when time-varying magnetic field gradients interact with the metallic structures of a magnetic resonance imaging (MRI) scanner. The secondary magnetic field produced by this induced current degrades the spatial and temporal performance of the primary field generated by the gradient coils. Although this undesired effect can be minimized by using actively and/or passively shielded gradient coils and current pre-emphasis techniques, a residual eddy current still remains in the MRI scanner structure. Accurate simulation of these eddy currents is important in the successful design of gradient coils and magnet cryostat vessels. Efficient methods for simulating eddy currents are currently restricted to cylindrical-symmetry. The approach presented in this paper divides thick conducting cylinders into thin layers (thinner than the skin depth) and expresses the current density on each as a Fourier series. The coupling between each mode of the Fourier series with every other is modeled with an inductive network method. In this way, the eddy currents induced in realistic cryostat surfaces by coils of arbitrary geometry can be simulated. The new method was validated by simulating a canonical problem and comparing the results against a commercially available software package. An accurate skin depth of 2.76 mm was calculated in 6 min with the new method. The currents induced by an actively shielded x-gradient coil were simulated assuming a finite length cylindrical cryostat consisting of three different conducting materials. Details of the temporal-spatial induced current diffusion process were simulated through all cryostat layers, which could not be efficiently simulated with any other method. With this data, all quantities that depend on the current density, such as the secondary magnetic field, are simply evaluated. Copyright © 2010 Elsevier Inc. All rights reserved.
An Unconventional Approach to Reducing Retinal Degeneration After Traumatic Ocular Injury
2017-09-01
AWARD NUMBER: W81XWH-15-1-0138 TITLE: An Unconventional Approach to Reducing Retinal Degeneration After Traumatic Ocular Injury PRINCIPAL...2015 - 30 Jun 2017 4. TITLE AND SUBTITLE An Unconventional Approach to Reducing Retinal Degeneration After Traumatic Ocular Injury 5 a . CONTRACT...optic confocal microscope system , test it, and establish protocols for the first successful in vivo retinal microvessel and pericyte advanced
A modular positron camera for the study of industrial processes
NASA Astrophysics Data System (ADS)
Leadbeater, T. W.; Parker, D. J.
2011-10-01
Positron imaging techniques rely on the detection of the back-to-back annihilation photons arising from positron decay within the system under study. A standard technique, called positron emitting particle tracking (PEPT) [1], uses a number of these detected events to rapidly determine the position of a positron emitting tracer particle introduced into the system under study. Typical applications of PEPT are in the study of granular and multi-phase materials in the disciplines of engineering and the physical sciences. Using components from redundant medical PET scanners a modular positron camera has been developed. This camera consists of a number of small independent detector modules, which can be arranged in custom geometries tailored towards the application in question. The flexibility of the modular camera geometry allows for high photon detection efficiency within specific regions of interest, the ability to study large and bulky systems and the application of PEPT to difficult or remote processes as the camera is inherently transportable.
Additive Manufacturing Infrared Inspection
NASA Technical Reports Server (NTRS)
Gaddy, Darrell
2014-01-01
Additive manufacturing is a rapid prototyping technology that allows parts to be built in a series of thin layers from plastic, ceramics, and metallics. Metallic additive manufacturing is an emerging form of rapid prototyping that allows complex structures to be built using various metallic powders. Significant time and cost savings have also been observed using the metallic additive manufacturing compared with traditional techniques. Development of the metallic additive manufacturing technology has advanced significantly over the last decade, although many of the techniques to inspect parts made from these processes have not advanced significantly or have limitations. Several external geometry inspection techniques exist such as Coordinate Measurement Machines (CMM), Laser Scanners, Structured Light Scanning Systems, or even traditional calipers and gages. All of the aforementioned techniques are limited to external geometry and contours or must use a contact probe to inspect limited internal dimensions. This presentation will document the development of a process for real-time dimensional inspection technique and digital quality record of the additive manufacturing process using Infrared camera imaging and processing techniques.
Application of Computer Axial Tomography (CAT) to measuring crop canopy geometry. [corn and soybeans
NASA Technical Reports Server (NTRS)
Bauer, M. E.; Vanderbilt, V. C. (Principal Investigator); Kilgore, R. W.
1981-01-01
The feasibility of using the principles of computer axial topography (CAT) to quantify the structure of crop canopies was investigated because six variables are needed to describe the position-orientation with time of a small piece of canopy foliage. Several cross sections were cut through the foliage of healthy, green corn and soybean canopies in the dent and full pod development stages, respectively. A photograph of each cross section representing the intersection of a plane with the foliage was enlarged and the air-foliage boundaries delineated by the plane were digitized. A computer program was written and used to reconstruct the cross section of the canopy. The approach used in applying optical computer axial tomography to measuring crop canopy geometry shows promise of being able to provide needed geometric information for input data to canopy reflectance models. The difficulty of using the CAT scanner to measure large canopies of crops like corn is discussed and a solution is proposed involving the measurement of plants one at a time.
TH-CD-201-05: Characterization of a Novel Light-Collimating Tank Optical-CT System for 3D Dosimetry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Miles, D; Yoon, S; Adamovics, J
Purpose: Comprehensive 3D dosimetry is highly desirable for advanced clinical QA, but costly optical readout techniques have hindered widespread implementation. Here, we present the first results from a cost-effective Integrated-lens Dry-tank Optical Scanner (IDOS), designed for convenient 3D dosimetry readout of radiochromic plastic dosimeters (e.g. PRESAGE). Methods: The scanner incorporates a novel transparent light-collimating tank, which collimates a point light source into parallel-ray CT geometry. The tank was designed using an in-house Monte-Carlo optical ray-tracing simulation, and was cast in polyurethane using a 3D printed mould. IDOS spatial accuracy was evaluated by imaging a set of custom optical phantoms, withmore » comparison to x-ray CT images. IDOS dose measurement performance was assessed by imaging PRESAGE dosimeters irradiated with simple known dose distributions (e.g., 4 field box 6MV treatment with Varian Linac). Direct comparisons were made to images from our gold standard DLOS scanner and calculated dose distributions from a commissioned Eclipse planning system. Results: All optical CT images were reconstructed at 1mm isotropic resolution. Comparison of IDOS and x-ray CT images of the geometric phantom demonstrated excellent IDOS geometric accuracy (sub-mm) throughout the dosimeter. IDOS measured 3D dose distribution agreed well with prediction from Eclipse, with 95% gamma pass rate at 3%/3mm. Cross-scanner dose measurement gamma analysis shows >90% of pixels passing at 3%/3mm. Conclusion: The first prototype of the IDOS system has demonstrated promising performance, with accurate dosimeter readout and negligible spatial distortion. The use of optical simulations and 3D printing to create a light collimating-tank has dramatically increased convenience and reduced costs by removing the need for expensive lenses and large volumes of refractive matching fluids.« less
Digital dental surface registration with laser scanner for orthodontics set-up planning
NASA Astrophysics Data System (ADS)
Alcaniz-Raya, Mariano L.; Albalat, Salvador E.; Grau Colomer, Vincente; Monserrat, Carlos A.
1997-05-01
We present an optical measuring system based on laser structured light suitable for its diary use in orthodontics clinics that fit four main requirements: (1) to avoid use of stone models, (2) to automatically discriminate geometric points belonging to teeth and gum, (3) to automatically calculate diagnostic parameters used by orthodontists, (4) to make use of low cost and easy to use technology for future commercial use. Proposed technique is based in the use of hydrocolloids mould used by orthodontists for stone model obtention. These mould of the inside of patient's mouth are composed of very fluent materials like alginate or hydrocolloids that reveal fine details of dental anatomy. Alginate mould are both very easy to obtain and very low costly. Once captured, alginate moulds are digitized by mean of a newly developed and patented 3D dental scanner. Developed scanner is based in the optical triangulation method based in the projection of a laser line on the alginate mould surface. Line deformation gives uncalibrated shape information. Relative linear movements of the mould with respect to the sensor head gives more sections thus obtaining a full 3D uncalibrated dentition model. Developed device makes use of redundant CCD in the sensor head and servocontrolled linear axis for mould movement. Last step is calibration to get a real and precise X, Y, Z image. All the process is done automatically. The scanner has been specially adapted for 3D dental anatomy capturing in order to fulfill specific requirements such as: scanning time, accuracy, security and correct acquisition of 'hidden points' in alginate mould. Measurement realized on phantoms with known geometry quite similar to dental anatomy present errors less than 0,1 mm. Scanning of global dental anatomy is 2 minutes, and generation of 3D graphics of dental cast takes approximately 30 seconds in a Pentium-based PC.
New cardiac cameras: single-photon emission CT and PET.
Slomka, Piotr J; Berman, Daniel S; Germano, Guido
2014-07-01
Nuclear cardiology instrumentation has evolved significantly in the recent years. Concerns about radiation dose and long acquisition times have propelled developments of dedicated high-efficiency cardiac SPECT scanners. Novel collimator designs, such as multipinhole or locally focusing collimators arranged in geometries that are optimized for cardiac imaging, have been implemented to enhance photon-detection sensitivity. Some of these new SPECT scanners use solid-state photon detectors instead of photomultipliers to improve image quality and to reduce the scanner footprint. These new SPECT devices allow dramatic up to 7-fold reduction in acquisition times or similar reduction in radiation dose. In addition, new hardware for photon attenuation correction allowing ultralow radiation doses has been offered by some vendors. To mitigate photon attenuation artifacts for the new SPECT scanners not equipped with attenuation correction hardware, 2-position (upright-supine or prone-supine) imaging has been proposed. PET hardware developments have been primarily driven by the requirements of oncologic imaging, but cardiac imaging can benefit from improved PET image quality and improved sensitivity of 3D systems. The time-of-flight reconstruction combined with resolution recovery techniques is now implemented by all major PET vendors. These new methods improve image contrast and image resolution and reduce image noise. High-sensitivity 3D PET without interplane septa allows reduced radiation dose for cardiac perfusion imaging. Simultaneous PET/MR hybrid system has been developed. Solid-state PET detectors with avalanche photodiodes or digital silicon photomultipliers have been introduced, and they offer improved imaging characteristics and reduced sensitivity to electromagnetic MR fields. Higher maximum count rate of the new PET detectors allows routine first-pass Rb-82 imaging, with 3D PET acquisition enabling clinical utilization of dynamic imaging with myocardial flow measurements for this tracer. The availability of high-end CT component in most PET/CT configurations enables hybrid multimodality cardiac imaging protocols with calcium scoring or CT angiography or both. Copyright © 2014. Published by Elsevier Inc.
NASA Astrophysics Data System (ADS)
Lajtos, Imre; Czernin, Johannes; Dahlbom, Magnus; Daver, Freddie; Emri, Miklos; Farshchi-Heydari, Salman; Forgacs, Attila; Hoh, Carl K.; Joszai, Istvan; Krizsan, Aron K.; Lantos, Judit; Major, Peter; Molnar, Jozsef; Opposits, Gabor; Tron, Lajos; Vera, David R.; Balkay, Laszlo
2014-06-01
The contrast recovery coefficients (CRC) were evaluated for five different small animal PET scanners: GE Explore Vista, Genisys4, MiniPET-2, nanoScan PC and Siemens Inveon. The NEMA NU-4 2008 performance test with the suggested image quality phantom (NU4IQ) does not allow the determination of the CRC values for the hot regions in the phantom. This drawback of NU4IQ phantom motivated us to develop a new method for this purpose. The method includes special acquisition and reconstruction protocols using the original phantom, and results in an artificially merged image enabling the evaluation of CRC values. An advantageous feature of this method is that it stops the cold wall effect from distorting the CRC calculation. Our suggested protocol results in a set of CRC values contributing to the characterization of small animal PET scanners. GATE simulations were also performed to validate the new method and verify the evaluated CRC values. We also demonstrated that the numerical values of this parameter depend on the actual object contrast of the hot region(s) and this mainly comes from the spillover effect. This effect was also studied while analysing the background activity level around the hot rods. We revealed that the calculated background mean values depended on the target contrast in a scanner specific manner. Performing the artificially merged imaging procedure and additional simulations using the micro hollow sphere (MHS) phantom geometry, we also proved that the inactive wall around the hot spheres can have a remarkable impact on the calculated CRC. In conclusion, we have shown that the proposed artificial merging procedure and the commonly used NU4IQ phantom prescribed by the NEMA NU-4 can easily deliver reliable CRC data otherwise unavailable for the NU4IQ phantom in the conventional protocol or the MHS phantom.
Lajtos, Imre; Czernin, Johannes; Dahlbom, Magnus; Daver, Freddie; Emri, Miklos; Farshchi-Heydari, Salman; Forgacs, Attila; Hoh, Carl K; Joszai, Istvan; Krizsan, Aron K; Lantos, Judit; Major, Peter; Molnar, Jozsef; Opposits, Gabor; Tron, Lajos; Vera, David R; Balkay, Laszlo
2014-06-07
The contrast recovery coefficients (CRC) were evaluated for five different small animal PET scanners: GE Explore Vista, Genisys4, MiniPET-2, nanoScan PC and Siemens Inveon. The NEMA NU-4 2008 performance test with the suggested image quality phantom (NU4IQ) does not allow the determination of the CRC values for the hot regions in the phantom. This drawback of NU4IQ phantom motivated us to develop a new method for this purpose. The method includes special acquisition and reconstruction protocols using the original phantom, and results in an artificially merged image enabling the evaluation of CRC values. An advantageous feature of this method is that it stops the cold wall effect from distorting the CRC calculation. Our suggested protocol results in a set of CRC values contributing to the characterization of small animal PET scanners. GATE simulations were also performed to validate the new method and verify the evaluated CRC values. We also demonstrated that the numerical values of this parameter depend on the actual object contrast of the hot region(s) and this mainly comes from the spillover effect. This effect was also studied while analysing the background activity level around the hot rods. We revealed that the calculated background mean values depended on the target contrast in a scanner specific manner. Performing the artificially merged imaging procedure and additional simulations using the micro hollow sphere (MHS) phantom geometry, we also proved that the inactive wall around the hot spheres can have a remarkable impact on the calculated CRC. In conclusion, we have shown that the proposed artificial merging procedure and the commonly used NU4IQ phantom prescribed by the NEMA NU-4 can easily deliver reliable CRC data otherwise unavailable for the NU4IQ phantom in the conventional protocol or the MHS phantom.
A novel electron gun for inline MRI-linac configurations.
Constantin, Dragoş E; Holloway, Lois; Keall, Paul J; Fahrig, Rebecca
2014-02-01
This work introduces a new electron gun geometry capable of robust functioning in the presence of a high strength external magnetic field for axisymmetric magnetic resonance imaging (MRI)-linac configurations. This allows an inline MRI-linac to operate without the need to isolate the linear accelerator (linac) using a magnetic shield. This MRI-linac integration approach not only leaves the magnet homogeneity unchanged but also provides the linac flexibility to move along the magnet axis of symmetry if the source to target distance needs to be adjusted. Simple electron gun geometry modifications of a Varian 600 C electron gun are considered and solved in the presence of an external magnetic field in order to determine a set of design principles for the new geometry. Based on these results, a new gun geometry is proposed and optimized in the fringe field of a 0.5 T open bore MRI magnet (GE Signa SP). A computer model for the 6 MeV Varian 600 C linac is used to determine the capture efficiency of the new electron gun-linac system in the presence of the fringe field of the same MRI scanner. The behavior of the new electron gun plus the linac system is also studied in the fringe fields of two other magnets, a 1.0 T prototype open bore magnet and a 1.5 T GE Conquest scanner. Simple geometrical modifications of the original electron gun geometry do not provide feasible solutions. However, these tests show that a smaller transverse cathode diameter with a flat surface and a slightly larger anode diameter could alleviate the current loss due to beam interactions with the anode in the presence of magnetic fields. Based on these findings, an initial geometry resembling a parallel plate capacitor with a hole in the anode is proposed. The optimization procedure finds a cathode-anode distance of 5 mm, a focusing electrode angle of 5°, and an anode drift tube length of 17.1 mm. Also, the linac can be displaced with ± 15 cm along the axis of the 0.5 T magnet without capture efficiency reduction below the experimental value in zero field. In this range of linac displacements, the electron beam generated by the new gun geometry is more effectively injected into the linac in the presence of an external magnetic field, resulting in approximately 20% increase of the target current compared to the original gun geometry behavior at zero field. The new gun geometry can generate and accelerate electron beams in external magnetic fields without current loss for fields higher than 0.11 T. The new electron-gun geometry is robust enough to function in the fringe fields of the other two magnets with a target current loss of no more than 16% with respect to the current obtained with no external magnetic fields. In this work, a specially designed electron gun was presented which can operate in the presence of axisymmetric strong magnetic fringe fields of MRI magnets. Computer simulations show that the electron gun can produce high quality beams which can be injected into a straight through linac such as Varian 600 C and accelerated with more efficiency in the presence of the external magnetic fields. Also, the new configuration allows linac displacements along the magnet axis in a range equal to the diameter of the imaging spherical volume of the magnet under consideration. The new electron gun-linac system can function in the fringe field of a MRI magnet if the field strength at the cathode position is higher than 0.11 T. The capture efficiency of the linac depends on the magnetic field strength and the field gradient. The higher the gradient the better the capture efficiency. The capture efficiency does not degrade more than 16%.
A novel electron gun for inline MRI-linac configurations
DOE Office of Scientific and Technical Information (OSTI.GOV)
Constantin, Dragoş E., E-mail: dragos.constantin@varian.com; Fahrig, Rebecca; Holloway, Lois
2014-02-15
Purpose: This work introduces a new electron gun geometry capable of robust functioning in the presence of a high strength external magnetic field for axisymmetric magnetic resonance imaging (MRI)-linac configurations. This allows an inline MRI-linac to operate without the need to isolate the linear accelerator (linac) using a magnetic shield. This MRI-linac integration approach not only leaves the magnet homogeneity unchanged but also provides the linac flexibility to move along the magnet axis of symmetry if the source to target distance needs to be adjusted. Methods: Simple electron gun geometry modifications of a Varian 600C electron gun are considered andmore » solved in the presence of an external magnetic field in order to determine a set of design principles for the new geometry. Based on these results, a new gun geometry is proposed and optimized in the fringe field of a 0.5 T open bore MRI magnet (GE Signa SP). A computer model for the 6 MeV Varian 600C linac is used to determine the capture efficiency of the new electron gun-linac system in the presence of the fringe field of the same MRI scanner. The behavior of the new electron gun plus the linac system is also studied in the fringe fields of two other magnets, a 1.0 T prototype open bore magnet and a 1.5 T GE Conquest scanner. Results: Simple geometrical modifications of the original electron gun geometry do not provide feasible solutions. However, these tests show that a smaller transverse cathode diameter with a flat surface and a slightly larger anode diameter could alleviate the current loss due to beam interactions with the anode in the presence of magnetic fields. Based on these findings, an initial geometry resembling a parallel plate capacitor with a hole in the anode is proposed. The optimization procedure finds a cathode-anode distance of 5 mm, a focusing electrode angle of 5°, and an anode drift tube length of 17.1 mm. Also, the linac can be displaced with ±15 cm along the axis of the 0.5 T magnet without capture efficiency reduction below the experimental value in zero field. In this range of linac displacements, the electron beam generated by the new gun geometry is more effectively injected into the linac in the presence of an external magnetic field, resulting in approximately 20% increase of the target current compared to the original gun geometry behavior at zero field. The new gun geometry can generate and accelerate electron beams in external magnetic fields without current loss for fields higher than 0.11 T. The new electron-gun geometry is robust enough to function in the fringe fields of the other two magnets with a target current loss of no more than 16% with respect to the current obtained with no external magnetic fields. Conclusions: In this work, a specially designed electron gun was presented which can operate in the presence of axisymmetric strong magnetic fringe fields of MRI magnets. Computer simulations show that the electron gun can produce high quality beams which can be injected into a straight through linac such as Varian 600C and accelerated with more efficiency in the presence of the external magnetic fields. Also, the new configuration allows linac displacements along the magnet axis in a range equal to the diameter of the imaging spherical volume of the magnet under consideration. The new electron gun-linac system can function in the fringe field of a MRI magnet if the field strength at the cathode position is higher than 0.11 T. The capture efficiency of the linac depends on the magnetic field strength and the field gradient. The higher the gradient the better the capture efficiency. The capture efficiency does not degrade more than 16%.« less
A novel electron gun for inline MRI-linac configurations
DOE Office of Scientific and Technical Information (OSTI.GOV)
Constantin, Dragoş E., E-mail: dragos.constantin@varian.com; Fahrig, Rebecca; Holloway, Lois
Purpose: This work introduces a new electron gun geometry capable of robust functioning in the presence of a high strength external magnetic field for axisymmetric magnetic resonance imaging (MRI)-linac configurations. This allows an inline MRI-linac to operate without the need to isolate the linear accelerator (linac) using a magnetic shield. This MRI-linac integration approach not only leaves the magnet homogeneity unchanged but also provides the linac flexibility to move along the magnet axis of symmetry if the source to target distance needs to be adjusted. Methods: Simple electron gun geometry modifications of a Varian 600C electron gun are considered andmore » solved in the presence of an external magnetic field in order to determine a set of design principles for the new geometry. Based on these results, a new gun geometry is proposed and optimized in the fringe field of a 0.5 T open bore MRI magnet (GE Signa SP). A computer model for the 6 MeV Varian 600C linac is used to determine the capture efficiency of the new electron gun-linac system in the presence of the fringe field of the same MRI scanner. The behavior of the new electron gun plus the linac system is also studied in the fringe fields of two other magnets, a 1.0 T prototype open bore magnet and a 1.5 T GE Conquest scanner. Results: Simple geometrical modifications of the original electron gun geometry do not provide feasible solutions. However, these tests show that a smaller transverse cathode diameter with a flat surface and a slightly larger anode diameter could alleviate the current loss due to beam interactions with the anode in the presence of magnetic fields. Based on these findings, an initial geometry resembling a parallel plate capacitor with a hole in the anode is proposed. The optimization procedure finds a cathode-anode distance of 5 mm, a focusing electrode angle of 5°, and an anode drift tube length of 17.1 mm. Also, the linac can be displaced with ±15 cm along the axis of the 0.5 T magnet without capture efficiency reduction below the experimental value in zero field. In this range of linac displacements, the electron beam generated by the new gun geometry is more effectively injected into the linac in the presence of an external magnetic field, resulting in approximately 20% increase of the target current compared to the original gun geometry behavior at zero field. The new gun geometry can generate and accelerate electron beams in external magnetic fields without current loss for fields higher than 0.11 T. The new electron-gun geometry is robust enough to function in the fringe fields of the other two magnets with a target current loss of no more than 16% with respect to the current obtained with no external magnetic fields. Conclusions: In this work, a specially designed electron gun was presented which can operate in the presence of axisymmetric strong magnetic fringe fields of MRI magnets. Computer simulations show that the electron gun can produce high quality beams which can be injected into a straight through linac such as Varian 600C and accelerated with more efficiency in the presence of the external magnetic fields. Also, the new configuration allows linac displacements along the magnet axis in a range equal to the diameter of the imaging spherical volume of the magnet under consideration. The new electron gun-linac system can function in the fringe field of a MRI magnet if the field strength at the cathode position is higher than 0.11 T. The capture efficiency of the linac depends on the magnetic field strength and the field gradient. The higher the gradient the better the capture efficiency. The capture efficiency does not degrade more than 16%.« less
Varieties of healing. 2: a taxonomy of unconventional healing practices.
Kaptchuk, T J; Eisenberg, D M
2001-08-07
The first of two essays in this issue demonstrated that the United States has had a rich history of medical pluralism. This essay seeks to present an overview of contemporary unconventional medical practices in the United States. No clear definition of "alternative medicine" is offered because it is a residual category composed of heterogeneous healing methods. A descriptive taxonomy of contemporary unconventional healing could be more helpful. Two broad categories of unconventional medicine are described here: a more prominent, "mainstream" complementary and alternative medicine (CAM) and a more culture-bound, "parochial" unconventional medicine. The CAM component can be divided into professional groups, layperson-initiated popular health reform movements, New Age healing, alternative psychological therapies, and non-normative scientific enterprises. The parochial category can be divided into ethno-medicine, religious healing, and folk medicine. A topologic examination of U.S. health care can provide an important conceptual framework through which health care providers can understand the current situation in U.S. medical pluralism.
Condensation on Slippery Asymmetric Bumps
NASA Astrophysics Data System (ADS)
Park, Kyoo-Chul; Kim, Philseok; Aizenberg, Joanna
Controlling dropwise condensation by designing surfaces that enable droplets to grow rapidly and be shed as quickly as possible is fundamental to water harvesting systems, thermal power generation, distillation towers, etc. However, cutting-edge approaches based on micro/nanoscale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach based on principles derived from Namib desert beetles, cacti, and pitcher plants that synergistically couples both aspects of condensation and outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bump geometry in promoting condensation, we show how to maximize vapor diffusion flux at the apex of convex millimetric bumps by optimizing curvature and shape. Integrating this apex geometry with a widening slope analogous to cactus spines couples rapid drop growth with fast directional transport, by creating a free energy profile that drives the drop down the slope. This coupling is further enhanced by a slippery, pitcher plant-inspired coating that facilitates feedback between coalescence-driven growth and capillary-driven motion. We further observe an unprecedented six-fold higher exponent in growth rate and much faster shedding time compared to other surfaces. We envision that our fundamental understanding and rational design strategy can be applied to a wide range of phase change applications.
Condensation on Slippery Asymmetric Bumps
NASA Astrophysics Data System (ADS)
Park, Kyoo-Chul; Kim, Philseok; Aizenberg, Joanna
2016-11-01
Controlling dropwise condensation by designing surfaces that enable droplets to grow rapidly and be shed as quickly as possible is fundamental to water harvesting systems, thermal power generation, distillation towers, etc. However, cutting-edge approaches based on micro/nanoscale textures suffer from intrinsic trade-offs that make it difficult to optimize both growth and transport at once. Here we present a conceptually different design approach based on principles derived from Namib desert beetles, cacti, and pitcher plants that synergistically couples both aspects of condensation and outperforms other synthetic surfaces. Inspired by an unconventional interpretation of the role of the beetle's bump geometry in promoting condensation, we show how to maximize vapor diffusion flux at the apex of convex millimetric bumps by optimizing curvature and shape. Integrating this apex geometry with a widening slope analogous to cactus spines couples rapid drop growth with fast directional transport, by creating a free energy profile that drives the drop down the slope. This coupling is further enhanced by a slippery, pitcher plant-inspired coating that facilitates feedback between coalescence-driven growth and capillary-driven motion. We further observe an unprecedented six-fold higher exponent in growth rate and much faster shedding time compared to other surfaces. We envision that our fundamental understanding and rational design strategy can be applied to a wide range of phase change applications.
Park, Woon Ik; Kim, Jong Min; Jeong, Jae Won; ...
2015-03-17
Phase change memory (PCM) is one of the most promising candidates for next-generation nonvolatile memory devices because of its high speed, excellent reliability, and outstanding scalability. But, the high switching current of PCM devices has been a critical hurdle to realize low-power operation. Although one solution is to reduce the switching volume of the memory, the resolution limit of photolithography hinders further miniaturization of device dimensions. Here, we employed unconventional self-assembly geometries obtained from blends of block copolymers (BCPs) to form ring-shaped hollow PCM nanostructures with an ultrasmall contact area between a phase-change material (Ge 2Sb 2Te 5) and amore » heater (TiN) electrode. The high-density (approximately 0.1 terabits per square inch) PCM nanoring arrays showed extremely small switching current of 2-3 mu A. Furthermore, the relatively small reset current of the ring-shaped PCM compared to the pillar-shaped devices is attributed to smaller switching volume, which is well supported by electro-thermal simulation results. Our approach may also be extended to other nonvolatile memory device applications such as resistive switching memory and magnetic storage devices, where the control of nanoscale geometry can significantly affect device performances.« less
NASA Astrophysics Data System (ADS)
Drohan, Patrick; Brittingham, Margaret; Mortensen, David; Barlow, Kathryn; Langlois, Lillie
2017-04-01
Worldwide unconventional shale-gas development has the potential to cause substantial landscape disturbance. The northeastern U.S.A. Appalachian Mountains across the states of Pennsylvania, West Virginia, Ohio, and Kentucky, are experiencing rapid landscape change as unconventional gas development occurs. We highlight several years of our research from this region in order to demonstrate the unique effect unconventional development has had on forested ecosystems. Infrastructure development has had a wide-reaching and varied effect on forested ecosystems and their services, which has resulted in temporary disturbances and long-lasting ones altering habitats and their viability. Corridor disturbances, such as pipelines, are the most spatially extensive disturbance and have substantially fragmented forest cover. Core forest disturbance, especially, in upper watershed positions, has resulted in disproportionate disturbances to forested ecosystems and their wildlife, and suggests a need for adaptive land management strategies to minimize and mitigate the effects of gas development. Soil and water resources are most affected by surface disturbances; however, soil protection and restoration strategies are evolving as the gas play changes economically. Dynamic soil properties related to soil organic matter and water availability respond uniquely to unconventional gas development and new, flexible restoration strategies are required to support long-term ecosystem stability. While the focus of management and research to date has been on acute disturbances to forested ecosystems, unconventional gas development is clearly a greater chronic, long-term disturbance factor in the Appalachian Mountains. Effectively managing ecosystems where unconventional gas development is occurring is a complicated interplay between public, private and corporate interests.
Unconventional natural gas development and birth outcomes in Pennsylvania, USA
Casey, Joan A.; Savitz, David A.; Rasmussen, Sara G.; Ogburn, Elizabeth L.; Pollak, Jonathan; Mercer, Dione G.; Schwartz, Brian S.
2015-01-01
Background Unconventional natural gas development has expanded rapidly. In Pennsylvania the number of producing wells increased from zero in 2005 to 3689 in 2013. To our knowledge, no prior publications have focused on unconventional natural gas development and birth outcomes. Methods We performed a retrospective cohort study using electronic health record data on 9384 mothers linked to 10946 neonates in the Geisinger Health System from January 2009-January 2013. We estimated cumulative exposure to unconventional natural gas development activity with an inverse-distance squared model that incorporated distance to the mother’s home; dates and durations of well pad development, drilling, and hydraulic fracturing; and production volume during the pregnancy. We used multilevel linear and logistic regression models to examine associations between activity index quartile and term birth weight, preterm birth, low 5 minute Apgar score and small size for gestational age, while controlling for potential confounding variables. Results In adjusted models, there was an association between unconventional natural gas development activity and preterm birth that increased across quartiles, with a fourth quartile odds ratio of 1.4 (95% CI: 1.0-1.9). There were no associations of activity with Apgar score, small for gestational age, or term birth weight (after adjustment for year). In a post-hoc analysis, there was an association with physician-recorded high-risk pregnancy identified from the problem list (fourth vs. first quartile, 1.3 [95% CI: 1.1-1.7]). Conclusion Prenatal residential exposure to unconventional natural gas development activity was associated with two pregnancy outcomes, adding to evidence that unconventional natural gas development may impact health. PMID:26426945
Conebeam CT of the head and neck, part 1: physical principles.
Miracle, A C; Mukherji, S K
2009-06-01
Conebeam x-ray CT (CBCT) is a developing imaging technique designed to provide relatively low-dose high-spatial-resolution visualization of high-contrast structures in the head and neck and other anatomic areas. This first installment in a 2-part review will address the physical principles underlying CBCT imaging as it is used in dedicated head and neck scanners. Concepts related to CBCT acquisition geometry, flat panel detection, and image quality will be explored in detail. Particular emphasis will be placed on technical limitations to low-contrast detectability and radiation dose. Proposed methods of x-ray scatter reduction will also be discussed.
Application of Optimization Techniques to Design of Unconventional Rocket Nozzle Configurations
NASA Technical Reports Server (NTRS)
Follett, W.; Ketchum, A.; Darian, A.; Hsu, Y.
1996-01-01
Several current rocket engine concepts such as the bell-annular tri-propellant engine, and the linear aerospike being proposed for the X-33 require unconventional three dimensional rocket nozzles which must conform to rectangular or sector shaped envelopes to meet integration constraints. These types of nozzles exist outside the current experience database, therefore, the application of efficient design methods for these propulsion concepts is critical to the success of launch vehicle programs. The objective of this work is to optimize several different nozzle configurations, including two- and three-dimensional geometries. Methodology includes coupling computational fluid dynamic (CFD) analysis to genetic algorithms and Taguchi methods as well as implementation of a streamline tracing technique. Results of applications are shown for several geometeries including: three dimensional thruster nozzles with round or super elliptic throats and rectangualar exits, two- and three-dimensional thrusters installed within a bell nozzle, and three dimensional thrusters with round throats and sector shaped exits. Due to the novel designs considered for this study, there is little experience which can be used to guide the effort and limit the design space. With a nearly infinite parameter space to explore, simple parametric design studies cannot possibly search the entire design space within the time frame required to impact the design cycle. For this reason, robust and efficient optimization methods are required to explore and exploit the design space to achieve high performance engine designs. Five case studies which examine the application of various techniques in the engineering environment are presented in this paper.
2017-05-25
Wilkinson US Army School of Advanced Military Studies United States Army Command and General Staff College Fort Leavenworth, Kansas 2017 Approved for...SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) Advanced Military Studies Program 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S...adversary’s unconventional threat. To test this framework, this monograph analyzes a case study of how Russia will likely use unconventional forces and
East-West paths to unconventional computing.
Adamatzky, Andrew; Akl, Selim; Burgin, Mark; Calude, Cristian S; Costa, José Félix; Dehshibi, Mohammad Mahdi; Gunji, Yukio-Pegio; Konkoli, Zoran; MacLennan, Bruce; Marchal, Bruno; Margenstern, Maurice; Martínez, Genaro J; Mayne, Richard; Morita, Kenichi; Schumann, Andrew; Sergeyev, Yaroslav D; Sirakoulis, Georgios Ch; Stepney, Susan; Svozil, Karl; Zenil, Hector
2017-12-01
Unconventional computing is about breaking boundaries in thinking, acting and computing. Typical topics of this non-typical field include, but are not limited to physics of computation, non-classical logics, new complexity measures, novel hardware, mechanical, chemical and quantum computing. Unconventional computing encourages a new style of thinking while practical applications are obtained from uncovering and exploiting principles and mechanisms of information processing in and functional properties of, physical, chemical and living systems; in particular, efficient algorithms are developed, (almost) optimal architectures are designed and working prototypes of future computing devices are manufactured. This article includes idiosyncratic accounts of 'unconventional computing' scientists reflecting on their personal experiences, what attracted them to the field, their inspirations and discoveries. Copyright © 2017 Elsevier Ltd. All rights reserved.
Valley- and spin-polarized oscillatory magneto-optical absorption in monolayer MoS2 quantum rings
NASA Astrophysics Data System (ADS)
Oliveira, D.; Villegas-Lelovsky, L.; Soler, M. A. G.; Qu, Fanyao
2018-03-01
Besides optical valley selectivity, strong spin-orbit interaction along with Berry curvature effects also leads to unconventional valley- and spin-polarized Landau levels in monolayer transition metal dichalcogenides (TMDCs) under a perpendicular magnetic field. We find that these unique properties are inherited to the magneto-optical absorption spectrum of the TMDC quantum rings (QRs). In addition, it is robust against variation of the magnetic flux and of the QR geometry. In stark contrast to the monolayer bulk material, the MoS2 QRs manifest themselves in both the optical valley selectivity and unprecedented size tunability of the frequency of the light absorbed. We also find that when the magnetic field setup is changed, the phase transition from Aharonov-Bohm (AB) quantum interference to aperiodic oscillation of magneto-optical absorption spectrum takes place. The exciton spectrum in a realistic finite thickness MoS2 QR is also discussed.
Advanced supersonic propulsion study, phases 3 and 4. [variable cycle engines
NASA Technical Reports Server (NTRS)
Allan, R. D.; Joy, W.
1977-01-01
An evaluation of various advanced propulsion concepts for supersonic cruise aircraft resulted in the identification of the double-bypass variable cycle engine as the most promising concept. This engine design utilizes special variable geometry components and an annular exhaust nozzle to provide high take-off thrust and low jet noise. The engine also provides good performance at both supersonic cruise and subsonic cruise. Emission characteristics are excellent. The advanced technology double-bypass variable cycle engine offers an improvement in aircraft range performance relative to earlier supersonic jet engine designs and yet at a lower level of engine noise. Research and technology programs required in certain design areas for this engine concept to realize its potential benefits include refined parametric analysis of selected variable cycle engines, screening of additional unconventional concepts, and engine preliminary design studies. Required critical technology programs are summarized.
Texture zeros and hierarchical masses from flavour (mis)alignment
NASA Astrophysics Data System (ADS)
Hollik, W. G.; Saldana-Salazar, U. J.
2018-03-01
We introduce an unconventional interpretation of the fermion mass matrix elements. As the full rotational freedom of the gauge-kinetic terms renders a set of infinite bases called weak bases, basis-dependent structures as mass matrices are unphysical. Matrix invariants, on the other hand, provide a set of basis-independent objects which are of more relevance. We employ one of these invariants to give a new parametrisation of the mass matrices. By virtue of it, one gains control over its implicit implications on several mass matrix structures. The key element is the trace invariant which resembles the equation of a hypersphere with a radius equal to the Frobenius norm of the mass matrix. With the concepts of alignment or misalignment we can identify texture zeros with certain alignments whereas Froggatt-Nielsen structures in the matrix elements are governed by misalignment. This method allows further insights of traditional approaches to the underlying flavour geometry.
Numerical model of water flow in a fractured basalt vadose zone: Box Canyon Site, Idaho
NASA Astrophysics Data System (ADS)
Doughty, Christine
2000-12-01
A numerical model of a fractured basalt vadose zone has been developed on the basis of the conceptual model described by Faybishenko et al. [[his issue]. The model has been used to simulate a ponded infiltration test in order to investigate infiltration through partially saturated fractured basalt. A key question addressed is how the fracture pattern geometry and fracture connectivity within a single basalt flow of the Snake River Plain basalt affect water infiltration. The two-dimensional numerical model extends from the ground surface to a perched water body 20 m below and uses an unconventional quasi-deterministic approach with explicit but highly simplified representation of major fractures and other important hydrogeologic features. The model adequately reproduces the majority of the field observation and provides insights into the infiltration process that cannot be obtained by data collection alone, demonstrating its value as a component of field studies.
Fully Automated Detection of Cloud and Aerosol Layers in the CALIPSO Lidar Measurements
NASA Technical Reports Server (NTRS)
Vaughan, Mark A.; Powell, Kathleen A.; Kuehn, Ralph E.; Young, Stuart A.; Winker, David M.; Hostetler, Chris A.; Hunt, William H.; Liu, Zhaoyan; McGill, Matthew J.; Getzewich, Brian J.
2009-01-01
Accurate knowledge of the vertical and horizontal extent of clouds and aerosols in the earth s atmosphere is critical in assessing the planet s radiation budget and for advancing human understanding of climate change issues. To retrieve this fundamental information from the elastic backscatter lidar data acquired during the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) mission, a selective, iterated boundary location (SIBYL) algorithm has been developed and deployed. SIBYL accomplishes its goals by integrating an adaptive context-sensitive profile scanner into an iterated multiresolution spatial averaging scheme. This paper provides an in-depth overview of the architecture and performance of the SIBYL algorithm. It begins with a brief review of the theory of target detection in noise-contaminated signals, and an enumeration of the practical constraints levied on the retrieval scheme by the design of the lidar hardware, the geometry of a space-based remote sensing platform, and the spatial variability of the measurement targets. Detailed descriptions are then provided for both the adaptive threshold algorithm used to detect features of interest within individual lidar profiles and the fully automated multiresolution averaging engine within which this profile scanner functions. The resulting fusion of profile scanner and averaging engine is specifically designed to optimize the trade-offs between the widely varying signal-to-noise ratio of the measurements and the disparate spatial resolutions of the detection targets. Throughout the paper, specific algorithm performance details are illustrated using examples drawn from the existing CALIPSO dataset. Overall performance is established by comparisons to existing layer height distributions obtained by other airborne and space-based lidars.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Müller, Mark, E-mail: mark-mueller@ph.tum.de; Yaroshenko, Andre; Velroyen, Astrid
In the field of biomedical X-ray imaging, novel techniques, such as phase-contrast and dark-field imaging, have the potential to enhance the contrast and provide complementary structural information about a specimen. In this paper, a first prototype of a preclinical X-ray phase-contrast CT scanner based on a Talbot-Lau interferometer is characterized. We present a study of the contrast-to-noise ratios for attenuation and phase-contrast images acquired with the prototype scanner. The shown results are based on a series of projection images and tomographic data sets of a plastic phantom in phase and attenuation-contrast recorded with varying acquisition settings. Subsequently, the signal andmore » noise distribution of different regions in the phantom were determined. We present a novel method for estimation of contrast-to-noise ratios for projection images based on the cylindrical geometry of the phantom. Analytical functions, representing the expected signal in phase and attenuation-contrast for a circular object, are fitted to individual line profiles of the projection data. The free parameter of the fit function is used to estimate the contrast and the goodness of the fit is determined to assess the noise in the respective signal. The results depict the dependence of the contrast-to-noise ratios on the applied source voltages, the number of steps of the phase stepping routine, and the exposure times for an individual step. Moreover, the influence of the number of projection angles on the image quality of CT slices is investigated. Finally, the implications for future imaging purposes with the scanner are discussed.« less
NASA Astrophysics Data System (ADS)
Li, Haijun; Li, Gaoming; Duan, Xiyu; Wang, Thomas D.
2017-02-01
Aimed to build a dual-axes confocal endomicroscope with an outer diameter of 5.5mm for in-vivo imaging applications, an electrostatic MEMS scanner has been developed to enable two dimensional (2D) light scanning in either horizontal plane or vertical cross-sectional plane. The device has a compact structure design to match the dual axes confocal architecture in the probe without blocking the collimated light beams of excitation and collection, and a cutting-free silicon-on-insulator(SOI) micromachining process is used for the fabrication. A novel lever-based gimbal-like mechanism is employed to enable three degrees of freedom motions for lateral and axial light scanning, and its geometry is optimized for achieving large deflection with high scanning speed. Based on parametric excitation, the device can work in resonant modes. Testing result shows that, up to +/-27° optical deflection angle for inner axis torsion motion with a frequency of 4.9kHz, up to +/-28.5° optical deflection angle for outer axis torsion motion with a frequency of 0.65kHz and 360μm stroke for out-of-plane translation motion with a frequency of 0.53kHz are achieved with <60V driving voltage. Based on these results, 2D imaging with frame rate of 5 10Hz and large field of view (1000μm x 1000μm in horizontal plane and 1000μm x 400μm in vertical plane) can be enabled by this scanner.
NASA Astrophysics Data System (ADS)
Szafarczyk, Anna; Gawałkiewicz, Rafał
2018-03-01
There are many ways of the geometry measurement of slim objects, with the application of geodetic and photogrammetric methods. A modern solution in the diagnostics of slim objects is the application of laser scanning, with the use of a scanner of a scanning total station. The point cloud, obtained from the surface of the scanned object gives the possibility of generating not only information on structural surface deformations, but also facilitates obtaining the data on the geometry of the axis of the building, as a basic indicator of the characteristics of its deformation. The cause of the change in the geometry of slim objects is the impact of many external and internal factors. These objects are located in the areas of working or closed underground mines. They can be impacted by the ground and they can face the results of the convergence of cavities. A specific structure of the salt rock mass causes subsequent convergence of the post-exploitation cavities, which has the influence on the behaviour of the terrain surface and the related objects. The authors analysed the impact of the changes in the rock mass and the surface on the changes of the industrial chimney in the Bochnia Salt Mine.
NASA Astrophysics Data System (ADS)
Bobek, Kinga; Jarosiński, Marek; Pachytel, Radomir
2017-04-01
Structural analysis of borehole core and microresistivity images yield an information about geometry of natural fracture network and their potential importance for reservoir stimulation. Density of natural fractures and their orientation in respect to the maximum horizontal stress has crucial meaning for hydraulic fractures propagation in unconventional reservoirs. We have investigated several hundred meters of continuous borehole core and corresponding microresistivity images (mostly XRMI) from six boreholes in the Pomeranian part of the Early Paleozoic Baltic Basin. In general, our results challenge the question about representatives of statistics based on structural analyses on a small shale volume represented by borehole core or borehole wall images and credibility of different sets of data. Most frequently, fractures observed in both XRMI and cores are steep, small strata-bound fractures and veins with minor mechanical aperture (0,1 mm in average). These veins create an orthogonal joint system, locally disturbed by fractures associated with normal or by gently dipping thrust faults. Mean fractures' height keeps in a range between 30-50 cm. Fracture density differs significantly among boreholes and Consistent Lithological Units (CLUs) but the most frequent means falls in a range 2-4 m-1. We have also payed an attention to bedding planes due to their expected coupling with natural fractures and their role as structural barriers for vertical fracture propagation. We aimed in construction for each CLU the so-called "mean brick", which size is limited by an average distance between two principal joint sets and between bedding fractures. In our study we have found out a discrepancy between structural profiles based on XRMI and core interpretation. For some CLUs joint fractures densities, are higher in cores than in XRMI. In this case, numerous small fractures were not recorded due to the limits of XRMI resolution. However, the most veins with aperture 0,1 mm, cemented with calcite, were clearly visible in scanner image. We have also observed significantly lower density of veins in core than in the XRMI that occurs systematically in one formation enriched with carbonate and dolomite. In this case, veins are not fractured in core and obliterated for bare eye by dolomitization, but are still contrastive in respect of electric resistance. Calculated density of bedding planes per 1 meter reveals systematically higher density of fractures observed on core than in the XRMI (depicted automatically by interpretation program). This difference may come from additional fracking due to relaxation of borehole core while recovery. Comparison of vertical joint fractures density with thickness of mechanical beds shows either lack of significant trends or a negative correlation (greater density of bedding fractures correspond to lower density of joints). This result, obtained for shale complexes contradict that derived for sandstone or limestone. Boundary between CLUs are visible on both: joint and bedding fracture density profiles. Considering small-scale faults and slickensides we have obtained good agreement between results of core and scanner interpretation. This study in the frame of ShaleMech Project funded by Polish Committee for Scientific Research is in progress and the results are preliminary.
Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants
NASA Astrophysics Data System (ADS)
Beer, S.; Streun, M.; Hombach, T.; Buehler, J.; Jahnke, S.; Khodaverdi, M.; Larue, H.; Minwuyelet, S.; Parl, C.; Roeb, G.; Schurr, U.; Ziemons, K.
2010-02-01
Positron emitters such as 11C, 13N and 18F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is 11CO2 since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET™ system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements.
Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants.
Beer, S; Streun, M; Hombach, T; Buehler, J; Jahnke, S; Khodaverdi, M; Larue, H; Minwuyelet, S; Parl, C; Roeb, G; Schurr, U; Ziemons, K
2010-02-07
Positron emitters such as (11)C, (13)N and (18)F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is (11)CO(2) since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements.
Helical cone beam CT with an asymmetrical detector.
Zamyatin, Alexander A; Taguchi, Katsuyuki; Silver, Michael D
2005-10-01
If a multislice or other area detector is shifted to one side to cover a larger field of view, then the data are truncated on one side. We propose a method to restore the missing data in helical cone-beam acquisitions that uses measured data on the longer side of the asymmetric detector array. The method is based on the idea of complementary rays, which is well known in fan beam geometry; in this paper we extend this concept to the cone-beam case. Different cases of complementary data coverage and dependence on the helical pitch are considered. The proposed method is used in our prototype 16-row CT scanner with an asymmetric detector and a 700 mm field of view. For evaluation we used scanned body phantom data and computer-simulated data. To simulate asymmetric truncation, the full, symmetric datasets were truncated by dropping either 22.5% or 45% from one side of the detector. Reconstructed images from the prototype scanner with the asymmetrical detector show excellent image quality in the extended field of view. The proposed method allows flexible helical pitch selection and can be used with overscan, short-scan, and super-short-scan reconstructions.
Task-based modeling and optimization of a cone-beam CT scanner for musculoskeletal imaging
DOE Office of Scientific and Technical Information (OSTI.GOV)
Prakash, P.; Zbijewski, W.; Gang, G. J.
2011-10-15
Purpose: This work applies a cascaded systems model for cone-beam CT imaging performance to the design and optimization of a system for musculoskeletal extremity imaging. The model provides a quantitative guide to the selection of system geometry, source and detector components, acquisition techniques, and reconstruction parameters. Methods: The model is based on cascaded systems analysis of the 3D noise-power spectrum (NPS) and noise-equivalent quanta (NEQ) combined with factors of system geometry (magnification, focal spot size, and scatter-to-primary ratio) and anatomical background clutter. The model was extended to task-based analysis of detectability index (d') for tasks ranging in contrast and frequencymore » content, and d' was computed as a function of system magnification, detector pixel size, focal spot size, kVp, dose, electronic noise, voxel size, and reconstruction filter to examine trade-offs and optima among such factors in multivariate analysis. The model was tested quantitatively versus the measured NPS and qualitatively in cadaver images as a function of kVp, dose, pixel size, and reconstruction filter under conditions corresponding to the proposed scanner. Results: The analysis quantified trade-offs among factors of spatial resolution, noise, and dose. System magnification (M) was a critical design parameter with strong effect on spatial resolution, dose, and x-ray scatter, and a fairly robust optimum was identified at M {approx} 1.3 for the imaging tasks considered. The results suggested kVp selection in the range of {approx}65-90 kVp, the lower end (65 kVp) maximizing subject contrast and the upper end maximizing NEQ (90 kVp). The analysis quantified fairly intuitive results--e.g., {approx}0.1-0.2 mm pixel size (and a sharp reconstruction filter) optimal for high-frequency tasks (bone detail) compared to {approx}0.4 mm pixel size (and a smooth reconstruction filter) for low-frequency (soft-tissue) tasks. This result suggests a specific protocol for 1 x 1 (full-resolution) projection data acquisition followed by full-resolution reconstruction with a sharp filter for high-frequency tasks along with 2 x 2 binning reconstruction with a smooth filter for low-frequency tasks. The analysis guided selection of specific source and detector components implemented on the proposed scanner. The analysis also quantified the potential benefits and points of diminishing return in focal spot size, reduced electronic noise, finer detector pixels, and low-dose limits of detectability. Theoretical results agreed quantitatively with the measured NPS and qualitatively with evaluation of cadaver images by a musculoskeletal radiologist. Conclusions: A fairly comprehensive model for 3D imaging performance in cone-beam CT combines factors of quantum noise, system geometry, anatomical background, and imaging task. The analysis provided a valuable, quantitative guide to design, optimization, and technique selection for a musculoskeletal extremities imaging system under development.« less
Water Use for Unconventional Energy Development: How Much, What Kind, and to What Reaction?
NASA Astrophysics Data System (ADS)
Grubert, E.
2017-12-01
Water resources—access to water, protection of water, and allocation of water in particular—are a major priority for Americans, but water use for the energy sector has not previously been well characterized. Water use and management associated with unconventional energy development is of special interest, in part because it is often new to the locations and contexts where it occurs. This presentation focuses on three major questions about water use for unconventional energy development, drawing on both engineering and anthropological research. First, using results from a recent study of water use for energy in the entire United States, how much water does the US use for unconventional energy resources, and how does that compare with water use for more mature fuel cycles? Second, based on that same study, what kind of water is used for these unconventional energy resource fuel cycles? Specifically, where does the water come from, and what is its quality? Finally, drawing on recent case studies in the US and elsewhere, what has the reaction been to these water uses, and why does that matter? Case studies focused on oil and natural gas resources illustrate societal reactions to issues of both water management, particularly related to induced seismicity associated with produced water injection, and water allocation, particularly related to hydraulic fracturing. Overall, recent work finds that public concern about water used for unconventional energy resources is often better explained by observed or anticipated local impacts and the uncertainty surrounding these impacts than by specifics about quantities, allocation, and management techniques. This work provides both quantitative and qualitative characterization of water management and allocation for unconventional energy development.
Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA.
Casey, Joan A; Savitz, David A; Rasmussen, Sara G; Ogburn, Elizabeth L; Pollak, Jonathan; Mercer, Dione G; Schwartz, Brian S
2016-03-01
Unconventional natural gas development has expanded rapidly. In Pennsylvania, the number of producing wells increased from 0 in 2005 to 3,689 in 2013. Few publications have focused on unconventional natural gas development and birth outcomes. We performed a retrospective cohort study using electronic health record data on 9,384 mothers linked to 10,946 neonates in the Geisinger Health System from January 2009 to January 2013. We estimated cumulative exposure to unconventional natural gas development activity with an inverse-distance squared model that incorporated distance to the mother's home; dates and durations of well pad development, drilling, and hydraulic fracturing; and production volume during the pregnancy. We used multilevel linear and logistic regression models to examine associations between activity index quartile and term birth weight, preterm birth, low 5-minute Apgar score and small size for gestational age birth, while controlling for potential confounding variables. In adjusted models, there was an association between unconventional natural gas development activity and preterm birth that increased across quartiles, with a fourth quartile odds ratio of 1.4 (95% confidence interval = 1.0, 1.9). There were no associations of activity with Apgar score, small for gestational age birth, or term birth weight (after adjustment for year). In a posthoc analysis, there was an association with physician-recorded high-risk pregnancy identified from the problem list (fourth vs. first quartile, 1.3 [95% confidence interval = 1.1, 1.7]). Prenatal residential exposure to unconventional natural gas development activity was associated with two pregnancy outcomes, adding to evidence that unconventional natural gas development may impact health.See Video Abstract at http://links.lww.com/EDE/B14.
GaN-based light-emitting diodes on various substrates: a critical review.
Li, Guoqiang; Wang, Wenliang; Yang, Weijia; Lin, Yunhao; Wang, Haiyan; Lin, Zhiting; Zhou, Shizhong
2016-05-01
GaN and related III-nitrides have attracted considerable attention as promising materials for application in optoelectronic devices, in particular, light-emitting diodes (LEDs). At present, sapphire is still the most popular commercial substrate for epitaxial growth of GaN-based LEDs. However, due to its relatively large lattice mismatch with GaN and low thermal conductivity, sapphire is not the most ideal substrate for GaN-based LEDs. Therefore, in order to obtain high-performance and high-power LEDs with relatively low cost, unconventional substrates, which are of low lattice mismatch with GaN, high thermal conductivity and low cost, have been tried as substitutes for sapphire. As a matter of fact, it is not easy to obtain high-quality III-nitride films on those substrates for various reasons. However, by developing a variety of techniques, distincts progress has been made during the past decade, with high-performance LEDs being successfully achieved on these unconventional substrates. This review focuses on state-of-the-art high-performance GaN-based LED materials and devices on unconventional substrates. The issues involved in the growth of GaN-based LED structures on each type of unconventional substrate are outlined, and the fundamental physics behind these issues is detailed. The corresponding solutions for III-nitride growth, defect control, and chip processing for each type of unconventional substrate are discussed in depth, together with a brief introduction to some newly developed techniques in order to realize LED structures on unconventional substrates. This is very useful for understanding the progress in this field of physics. In this review, we also speculate on the prospects for LEDs on unconventional substrates.
ON A GENERALIZED SELF-SIMILARITY IN THE p-ADIC FIELD
NASA Astrophysics Data System (ADS)
Mukhamedov, Farrukh; Khakimov, Otabek
2016-08-01
In the present paper, we introduce a new set which defines a generalized self-similar set for contractive functions {fi}i=1N on the unit ball ℤp of p-adic numbers. This set is called unconventional limit set. We prove that the unconventional limit set is compact, perfect and uniformly disconnected. Moreover, we provide an example of two contractions for which the corresponding unconventional limiting set is quasi-symmetrically equivalent to the symbolic Cantor set.
2008-05-28
OVERWORKED , YOUNG, HOMOGENOUS, & MACHO TO FULFILL THE UNCONVENTIONAL DEMANDS OF THE LONG WAR? SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR...U.S. Joint Special Operations Forces: Two Few, Overworked , Young, Homogenous & Macho to Fulfill the Unconventional Demands of the Long War? 5a...to be the targets of nearly daily mortar, improvised explosive devices (IEDs), and occasional suicide vehicle-borne IED (SVBIED) attacks. It
NASA Astrophysics Data System (ADS)
Moroni, Giovanni; Syam, Wahyudin P.; Petrò, Stefano
2014-08-01
Product quality is a main concern today in manufacturing; it drives competition between companies. To ensure high quality, a dimensional inspection to verify the geometric properties of a product must be carried out. High-speed non-contact scanners help with this task, by both speeding up acquisition speed and increasing accuracy through a more complete description of the surface. The algorithms for the management of the measurement data play a critical role in ensuring both the measurement accuracy and speed of the device. One of the most fundamental parts of the algorithm is the procedure for fitting the substitute geometry to a cloud of points. This article addresses this challenge. Three relevant geometries are selected as case studies: a non-linear least-squares fitting of a circle, sphere and cylinder. These geometries are chosen in consideration of their common use in practice; for example the sphere is often adopted as a reference artifact for performance verification of a coordinate measuring machine (CMM) and a cylinder is the most relevant geometry for a pin-hole relation as an assembly feature to construct a complete functioning product. In this article, an improvement of the initial point guess for the Levenberg-Marquardt (LM) algorithm by employing a chaos optimization (CO) method is proposed. This causes a performance improvement in the optimization of a non-linear function fitting the three geometries. The results show that, with this combination, a higher quality of fitting results a smaller norm of the residuals can be obtained while preserving the computational cost. Fitting an ‘incomplete-point-cloud’, which is a situation where the point cloud does not cover a complete feature e.g. from half of the total part surface, is also investigated. Finally, a case study of fitting a hemisphere is presented.
Design and life-cycle considerations for unconventional-reservoir wells
DOE Office of Scientific and Technical Information (OSTI.GOV)
Miskimins, J.L.
2009-05-15
This paper provides an overview of design and life-cycle considerations for certain unconventional-reservoir wells. An overview of unconventional-reservoir definitions is provided. Well design and life-cycle considerations are addressed from three aspects: upfront reservoir development, initial well completion, and well-life and long-term considerations. Upfront-reservoir-development issues discussed include well spacing, well orientation, reservoir stress orientations, and tubular metallurgy. Initial-well-completion issues include maximum treatment pressures and rates, treatment diversion, treatment staging, flowback and cleanup, and dewatering needs. Well-life and long-term discussions include liquid loading, corrosion, refracturing and associated fracture reorientation, and the cost of abandonment. These design considerations are evaluated with case studiesmore » for five unconventional-reservoir types: shale gas (Barnett shale), tight gas (Jonah feld), tight oil (Bakken play), coalbed methane (CBM) (San Juan basin), and tight heavy oil (Lost Hills field). In evaluating the life cycle and design of unconventional-reservoir wells, 'one size' does not fit all and valuable knowledge and a shortening of the learning curve can be achieved for new developments by studying similar, more-mature fields.« less
The health implications of unconventional natural gas development in Pennsylvania.
Peng, Lizhong; Meyerhoefer, Chad; Chou, Shin-Yi
2018-06-01
We investigate the health impacts of unconventional natural gas development of Marcellus shale in Pennsylvania between 2001 and 2013 by merging well permit data from the Pennsylvania Department of Environmental Protection with a database of all inpatient hospital admissions. After comparing changes in hospitalization rates over time for air pollution-sensitive diseases in counties with unconventional gas wells to changes in hospitalization rates in nonwell counties, we find a significant association between shale gas development and hospitalizations for pneumonia among the elderly, which is consistent with higher levels of air pollution resulting from unconventional natural gas development. We note that the lack of any detectable impact of shale gas development on younger populations may be due to unobserved factors contemporaneous with drilling, such as migration. Copyright © 2018 John Wiley & Sons, Ltd.
Bootstrap Current for the Edge Pedestal Plasma in a Diverted Tokamak Geometry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Koh, S.; Chang, C. S.; Ku, S.
The edge bootstrap current plays a critical role in the equilibrium and stability of the steep edge pedestal plasma. The pedestal plasma has an unconventional and difficult neoclassical property, as compared with the core plasma. It has a narrow passing particle region in velocity space that can be easily modified or destroyed by Coulomb collisions. At the same time, the edge pedestal plasma has steep pressure and electrostatic potential gradients whose scale-lengths are comparable with the ion banana width, and includes a magnetic separatrix surface, across which the topological properties of the magnetic field and particle orbits change abruptly. Amore » driftkinetic particle code XGC0, equipped with a mass-momentum-energy conserving collision operator, is used to study the edge bootstrap current in a realistic diverted magnetic field geometry with a self-consistent radial electric field. When the edge electrons are in the weakly collisional banana regime, surprisingly, the present kinetic simulation confirms that the existing analytic expressions [represented by O. Sauter et al. , Phys. Plasmas 6 , 2834 (1999)] are still valid in this unconventional region, except in a thin radial layer in contact with the magnetic separatrix. The agreement arises from the dominance of the electron contribution to the bootstrap current compared with ion contribution and from a reasonable separation of the trapped-passing dynamics without a strong collisional mixing. However, when the pedestal electrons are in plateau-collisional regime, there is significant deviation of numerical results from the existing analytic formulas, mainly due to large effective collisionality of the passing and the boundary layer trapped particles in edge region. In a conventional aspect ratio tokamak, the edge bootstrap current from kinetic simulation can be significantly less than that from the Sauter formula if the electron collisionality is high. On the other hand, when the aspect ratio is close to unity, the collisional edge bootstrap current can be significantly greater than that from the Sauter formula. Rapid toroidal rotation of the magnetic field lines at the high field side of a tight aspect-ratio tokamak is believed to be the cause of the different behavior. A new analytic fitting formula, as a simple modification to the Sauter formula, is obtained to bring the analytic expression to a better agreement with the edge kinetic simulation results« less
Bootstrap current for the edge pedestal plasma in a diverted tokamak geometry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Koh, S.; Choe, W.; Chang, C. S.
The edge bootstrap current plays a critical role in the equilibrium and stability of the steep edge pedestal plasma. The pedestal plasma has an unconventional and difficult neoclassical property, as compared with the core plasma. It has a narrow passing particle region in velocity space that can be easily modified or destroyed by Coulomb collisions. At the same time, the edge pedestal plasma has steep pressure and electrostatic potential gradients whose scale-lengths are comparable with the ion banana width, and includes a magnetic separatrix surface, across which the topological properties of the magnetic field and particle orbits change abruptly. Amore » drift-kinetic particle code XGC0, equipped with a mass-momentum-energy conserving collision operator, is used to study the edge bootstrap current in a realistic diverted magnetic field geometry with a self-consistent radial electric field. When the edge electrons are in the weakly collisional banana regime, surprisingly, the present kinetic simulation confirms that the existing analytic expressions [represented by O. Sauter et al., Phys. Plasmas 6, 2834 (1999)] are still valid in this unconventional region, except in a thin radial layer in contact with the magnetic separatrix. The agreement arises from the dominance of the electron contribution to the bootstrap current compared with ion contribution and from a reasonable separation of the trapped-passing dynamics without a strong collisional mixing. However, when the pedestal electrons are in plateau-collisional regime, there is significant deviation of numerical results from the existing analytic formulas, mainly due to large effective collisionality of the passing and the boundary layer trapped particles in edge region. In a conventional aspect ratio tokamak, the edge bootstrap current from kinetic simulation can be significantly less than that from the Sauter formula if the electron collisionality is high. On the other hand, when the aspect ratio is close to unity, the collisional edge bootstrap current can be significantly greater than that from the Sauter formula. Rapid toroidal rotation of the magnetic field lines at the high field side of a tight aspect-ratio tokamak is believed to be the cause of the different behavior. A new analytic fitting formula, as a simple modification to the Sauter formula, is obtained to bring the analytic expression to a better agreement with the edge kinetic simulation results.« less
Theory of disordered unconventional superconductors
DOE Office of Scientific and Technical Information (OSTI.GOV)
Keles, A.; Andreev, A. V.; Spivak, B. Z., E-mail: spivak@uw.edu
In contrast to conventional s-wave superconductivity, unconventional (e.g., p- or d-wave) superconductivity is strongly suppressed even by relatively weak disorder. Upon approaching the superconductormetal transition, the order parameter amplitude becomes increasingly inhomogeneous, leading to effective granularity and a phase ordering transition described by the Mattis model of spin glasses. One consequence of this is that at sufficiently low temperatures, between the clean unconventional superconducting and the diffusive metallic phases, there is necessarily an intermediate superconducting phase that exhibits s-wave symmetry on macroscopic scales.
PerSEUS: Ultra-Low-Power High Performance Computing for Plasma Simulations
NASA Astrophysics Data System (ADS)
Doxas, I.; Andreou, A.; Lyon, J.; Angelopoulos, V.; Lu, S.; Pritchett, P. L.
2017-12-01
Peta-op SupErcomputing Unconventional System (PerSEUS) aims to explore the use for High Performance Scientific Computing (HPC) of ultra-low-power mixed signal unconventional computational elements developed by Johns Hopkins University (JHU), and demonstrate that capability on both fluid and particle Plasma codes. We will describe the JHU Mixed-signal Unconventional Supercomputing Elements (MUSE), and report initial results for the Lyon-Fedder-Mobarry (LFM) global magnetospheric MHD code, and a UCLA general purpose relativistic Particle-In-Cell (PIC) code.
Investigating operation at geometrically unconventional intersections.
DOT National Transportation Integrated Search
2014-08-01
This report documents the development of decision assistance curves (DAC) for unconventional intersections, particularly : median U-turns (MUT), continuous flow intersections (CFI), and jughandles. The operational measure of effectiveness : such as d...
Unconventional Oil and Gas Extraction Effluent Guidelines
Overview and documents for the Unconventional Oil and Gas Extraction Pretreatment Standards final rule (6/28/2016), direct final rule (Sept. 2016) and proposed rule (Sept. 2016). 40 CFR Part 435, Subpart C.
Quantity of flowback and produced waters from unconventional oil and gas exploration.
Kondash, Andrew J; Albright, Elizabeth; Vengosh, Avner
2017-01-01
The management and disposal of flowback and produced waters (FP water) is one of the greatest challenges associated with unconventional oil and gas development. The development and production of unconventional natural gas and oil is projected to increase in the coming years, and a better understanding of the volume and quality of FP water is crucial for the safe management of the associated wastewater. We analyzed production data using multiple statistical methods to estimate the total FP water generated per well from six of the major unconventional oil and gas formations in the United States. The estimated median volume ranges from 1.7 to 14.3millionL (0.5 to 3.8milliongal) of FP per well over the first 5-10years of production. Using temporal volume production and water quality data, we show a rapid increase of the salinity associated with a decrease of FP production rates during the first months of unconventional oil and gas production. Based on mass-balance calculations, we estimate that only 4-8% of FP water is composed of returned hydraulic fracturing fluids, while the remaining 92-96% of FP water is derived from naturally occurring formation brines that is extracted together with oil and gas. The salinity and chemical composition of the formation brines are therefore the main limiting factors for beneficial reuse of unconventional oil and gas wastewater. Copyright © 2016 Elsevier B.V. All rights reserved.
Davis, Kendall M; Nguyen, Michael N; McClung, Maureen R; Moran, Matthew D
2018-05-01
The United States energy industry is transforming with the rapid development of alternative energy sources and technological advancements in fossil fuels. Two major changes include the growth of wind turbines and unconventional oil and gas. We measured land-use impacts and associated ecosystem services costs of unconventional gas and wind energy development within the Anadarko Basin of the Oklahoma Woodford Shale, an area that has experienced large increases in both energy sectors. Unconventional gas wells developed three times as much land compared to wind turbines (on a per unit basis), resulting in higher ecosystem services costs for gas. Gas wells had higher impacts on intensive agricultural lands (i.e., row crops) compared to wind turbines that had higher impacts on natural grasslands/pastures. Because wind turbines produced on average less energy compared to gas wells, the average land-use-related ecosystem cost per gigajoule of energy produced was almost the same. Our results demonstrate that both unconventional gas and wind energy have substantial impacts on land use, which likely affect wildlife populations and land-use-related ecosystem services. Although wind energy does not have the associated greenhouse gas emissions, we suggest that the direct impacts on ecosystems in terms of land use are similar to unconventional fossil fuels. Considering the expected rapid global expansion of these two forms of energy production, many ecosystems are likely to be at risk.
Hidden magnetism and quantum criticality in the heavy fermion superconductor CeRhIn5.
Park, Tuson; Ronning, F; Yuan, H Q; Salamon, M B; Movshovich, R; Sarrao, J L; Thompson, J D
2006-03-02
With only a few exceptions that are well understood, conventional superconductivity does not coexist with long-range magnetic order (for example, ref. 1). Unconventional superconductivity, on the other hand, develops near a phase boundary separating magnetically ordered and magnetically disordered phases. A maximum in the superconducting transition temperature T(c) develops where this boundary extrapolates to zero Kelvin, suggesting that fluctuations associated with this magnetic quantum-critical point are essential for unconventional superconductivity. Invariably, though, unconventional superconductivity masks the magnetic phase boundary when T < T(c), preventing proof of a magnetic quantum-critical point. Here we report specific-heat measurements of the pressure-tuned unconventional superconductor CeRhIn5 in which we find a line of quantum-phase transitions induced inside the superconducting state by an applied magnetic field. This quantum-critical line separates a phase of coexisting antiferromagnetism and superconductivity from a purely unconventional superconducting phase, and terminates at a quantum tetracritical point where the magnetic field completely suppresses superconductivity. The T --> 0 K magnetic field-pressure phase diagram of CeRhIn5 is well described with a theoretical model developed to explain field-induced magnetism in the high-T(c) copper oxides, but in which a clear delineation of quantum-phase boundaries has not been possible. These experiments establish a common relationship among hidden magnetism, quantum criticality and unconventional superconductivity in copper oxides and heavy-electron systems such as CeRhIn5.
A robust and hierarchical approach for the automatic co-registration of intensity and visible images
NASA Astrophysics Data System (ADS)
González-Aguilera, Diego; Rodríguez-Gonzálvez, Pablo; Hernández-López, David; Luis Lerma, José
2012-09-01
This paper presents a new robust approach to integrate intensity and visible images which have been acquired with a terrestrial laser scanner and a calibrated digital camera, respectively. In particular, an automatic and hierarchical method for the co-registration of both sensors is developed. The approach integrates several existing solutions to improve the performance of the co-registration between range-based and visible images: the Affine Scale-Invariant Feature Transform (A-SIFT), the epipolar geometry, the collinearity equations, the Groebner basis solution and the RANdom SAmple Consensus (RANSAC), integrating a voting scheme. The approach presented herein improves the existing co-registration approaches in automation, robustness, reliability and accuracy.
Compact and mobile high resolution PET brain imager
Majewski, Stanislaw [Yorktown, VA; Proffitt, James [Newport News, VA
2011-02-08
A brain imager includes a compact ring-like static PET imager mounted in a helmet-like structure. When attached to a patient's head, the helmet-like brain imager maintains the relative head-to-imager geometry fixed through the whole imaging procedure. The brain imaging helmet contains radiation sensors and minimal front-end electronics. A flexible mechanical suspension/harness system supports the weight of the helmet thereby allowing for patient to have limited movements of the head during imaging scans. The compact ring-like PET imager enables very high resolution imaging of neurological brain functions, cancer, and effects of trauma using a rather simple mobile scanner with limited space needs for use and storage.
Pompa, Andrea; De Marchis, Francesca; Pallotta, Maria Teresa; Benitez-Alfonso, Yoselin; Jones, Alexandra; Schipper, Kerstin; Moreau, Kevin; Žárský, Viktor; Di Sansebastiano, Gian Pietro; Bellucci, Michele
2017-01-01
Many proteins and cargoes in eukaryotic cells are secreted through the conventional secretory pathway that brings proteins and membranes from the endoplasmic reticulum to the plasma membrane, passing through various cell compartments, and then the extracellular space. The recent identification of an increasing number of leaderless secreted proteins bypassing the Golgi apparatus unveiled the existence of alternative protein secretion pathways. Moreover, other unconventional routes for secretion of soluble or transmembrane proteins with initial endoplasmic reticulum localization were identified. Furthermore, other proteins normally functioning in conventional membrane traffic or in the biogenesis of unique plant/fungi organelles or in plasmodesmata transport seem to be involved in unconventional secretory pathways. These alternative pathways are functionally related to biotic stress and development, and are becoming more and more important in cell biology studies in yeast, mammalian cells and in plants. The city of Lecce hosted specialists working on mammals, plants and microorganisms for the inaugural meeting on “Unconventional Protein and Membrane Traffic” (UPMT) during 4–7 October 2016. The main aim of the meeting was to include the highest number of topics, summarized in this report, related to the unconventional transport routes of protein and membranes. PMID:28346345
Impact of Unconventional Gas Technology in the Annual Energy Outlook 2000
2000-01-01
This paper describes the methodology used in the National Energy Modeling System (NEMS) to represent unconventional gas technologies and their impacts on projections in the Annual Energy Outlook 2000 (AEO2000).
NASA Astrophysics Data System (ADS)
Schnitzer, Ory; Yariv, Ehud
2017-07-01
The gross amplification of the fluid velocity in pressure-driven flows due to the introduction of superhydrophobic walls is commonly quantified by an effective slip length. The canonical duct-flow geometry involves a periodic structure of longitudinal shear-free stripes at either one or both of the bounding walls, corresponding to flat-meniscus gas bubbles trapped within a periodic array of grooves. This grating configuration is characterized by two geometric parameters, namely the ratio κ of channel width to microstructure period and the areal fraction Δ of the shear-free stripes. For wide channels, κ ≫1 , this geometry is known to possess an approximate solution where the dimensionless slip length λ , normalized by the duct semiwidth, is small, indicating a weak superhydrophobic effect. We here address the other extreme of narrow channels, κ ≪1 , identifying large O (κ-2) values of λ for the symmetric configuration, where both bounding walls are superhydrophobic. This velocity enhancement is associated with an unconventional Poiseuille-like flow profile where the parabolic velocity variation takes place in a direction parallel (rather than perpendicular) to the boundaries. Use of matched asymptotic expansions and conformal-mapping techniques provides λ up to O (κ-1) , establishing the approximationλ ˜κ-2Δ/33 +κ-1Δ/2π ln4 +⋯, which is in excellent agreement with a semianalytic solution of the dual equations governing the respective coefficients of a Fourier-series representation of the fluid velocity. No similar singularity occurs in the corresponding asymmetric configuration, involving a single superhydrophobic wall; in that geometry, a Hele-Shaw approximation shows that λ =O (1 ) .
NASA Astrophysics Data System (ADS)
Efthimiou, N.; Papadimitroulas, P.; Kostou, T.; Loudos, G.
2015-09-01
Commercial clinical and preclinical PET scanners rely on the full cylindrical geometry for whole body scans as well as for dedicated organs. In this study we propose the construction of a low cost dual-head C-shaped PET system dedicated for small animal brain imaging. Monte Carlo simulation studies were performed using GATE toolkit to evaluate the optimum design in terms of sensitivity, distortions in the FOV and spatial resolution. The PET model is based on SiPMs and BGO pixelated arrays. Four different configurations with C- angle 0°, 15°, 30° and 45° within the modules, were considered. Geometrical phantoms were used for the evaluation process. STIR software, extended by an efficient multi-threaded ray tracing technique, was used for the image reconstruction. The algorithm automatically adjusts the size of the FOV according to the shape of the detector's geometry. The results showed improvement in sensitivity of ∼15% in case of 45° C-angle compared to the 0° case. The spatial resolution was found 2 mm for 45° C-angle.
Castellazzi, Giovanni; D'Altri, Antonio Maria; Bitelli, Gabriele; Selvaggi, Ilenia; Lambertini, Alessandro
2015-07-28
In this paper, a new semi-automatic procedure to transform three-dimensional point clouds of complex objects to three-dimensional finite element models is presented and validated. The procedure conceives of the point cloud as a stacking of point sections. The complexity of the clouds is arbitrary, since the procedure is designed for terrestrial laser scanner surveys applied to buildings with irregular geometry, such as historical buildings. The procedure aims at solving the problems connected to the generation of finite element models of these complex structures by constructing a fine discretized geometry with a reduced amount of time and ready to be used with structural analysis. If the starting clouds represent the inner and outer surfaces of the structure, the resulting finite element model will accurately capture the whole three-dimensional structure, producing a complex solid made by voxel elements. A comparison analysis with a CAD-based model is carried out on a historical building damaged by a seismic event. The results indicate that the proposed procedure is effective and obtains comparable models in a shorter time, with an increased level of automation.
Pedestrian Detection by Laser Scanning and Depth Imagery
NASA Astrophysics Data System (ADS)
Barsi, A.; Lovas, T.; Molnar, B.; Somogyi, A.; Igazvolgyi, Z.
2016-06-01
Pedestrian flow is much less regulated and controlled compared to vehicle traffic. Estimating flow parameters would support many safety, security or commercial applications. Current paper discusses a method that enables acquiring information on pedestrian movements without disturbing and changing their motion. Profile laser scanner and depth camera have been applied to capture the geometry of the moving people as time series. Procedures have been developed to derive complex flow parameters, such as count, volume, walking direction and velocity from laser scanned point clouds. Since no images are captured from the faces of pedestrians, no privacy issues raised. The paper includes accuracy analysis of the estimated parameters based on video footage as reference. Due to the dense point clouds, detailed geometry analysis has been conducted to obtain the height and shoulder width of pedestrians and to detect whether luggage has been carried or not. The derived parameters support safety (e.g. detecting critical pedestrian density in mass events), security (e.g. detecting prohibited baggage in endangered areas) and commercial applications (e.g. counting pedestrians at all entrances/exits of a shopping mall).
Silicon solar cell process development, fabrication and analysis
NASA Technical Reports Server (NTRS)
Minahan, J. A.
1981-01-01
The fabrication of solar cells from several unconventional silicon materials is described, and cell performance measured and analyzed. Unconventional materials evaluated are edge defined film fed grown (EFG), heat exchanger method (HEM), dendritic web grown, and continuous CZ silicons. Resistivity, current voltage, and spectral sensitivity of the cells were measured. Current voltage was measured under AM0 and AM1 conditions. Maximum conversion efficiencies of cells fabricated from these and other unconventional silicons were compared and test results analyzed. The HEM and continuous CZ silicon were found to be superior to silicon materials considered previously.
REVIEW ARTICLE: Unconventional isotope effects in the high-temperature cuprate superconductors
NASA Astrophysics Data System (ADS)
Zhao, Guo-meng; Keller, H.; Conder, K.
2001-07-01
We review various isotope effects in the high-Tc cuprate superconductors to assess the role of the electron-phonon interaction in the basic physics of these materials. Of particular interest are the unconventional isotope effects on the supercarrier mass, on the charge-stripe formation temperature, on the pseudogap formation temperature, on the electron paramagnetic resonance (EPR) linewidth, on the spin-glass freezing temperature and on the antiferromagnetic ordering temperature. The observed unconventional isotope effects strongly suggest that lattice vibrations play an important role in the microscopic pairing mechanism of high-temperature superconductivity.
Radon in unconventional natural gas from gulf coast geopressured-geothermal reservoirs
Kraemer, T.F.
1986-01-01
Radon-222 has been measured in natural gas produced from experimental geopressured-geothermal test wells. Comparison with published data suggests that while radon activity of this unconventional natural gas resource is higher than conventional gas produced in the gulf coast, it is within the range found for conventional gas produced throughout the U.S. A method of predicting the likely radon activity of this unconventional gas is described on the basis of the data presented, methane solubility, and known or assumed reservoir conditions of temperature, fluid pressure, and formation water salinity.
Transmission imaging for integrated PET-MR systems.
Bowen, Spencer L; Fuin, Niccolò; Levine, Michael A; Catana, Ciprian
2016-08-07
Attenuation correction for PET-MR systems continues to be a challenging problem, particularly for body regions outside the head. The simultaneous acquisition of transmission scan based μ-maps and MR images on integrated PET-MR systems may significantly increase the performance of and offer validation for new MR-based μ-map algorithms. For the Biograph mMR (Siemens Healthcare), however, use of conventional transmission schemes is not practical as the patient table and relatively small diameter scanner bore significantly restrict radioactive source motion and limit source placement. We propose a method for emission-free coincidence transmission imaging on the Biograph mMR. The intended application is not for routine subject imaging, but rather to improve and validate MR-based μ-map algorithms; particularly for patient implant and scanner hardware attenuation correction. In this study we optimized source geometry and assessed the method's performance with Monte Carlo simulations and phantom scans. We utilized a Bayesian reconstruction algorithm, which directly generates μ-map estimates from multiple bed positions, combined with a robust scatter correction method. For simulations with a pelvis phantom a single torus produced peak noise equivalent count rates (34.8 kcps) dramatically larger than a full axial length ring (11.32 kcps) and conventional rotating source configurations. Bias in reconstructed μ-maps for head and pelvis simulations was ⩽4% for soft tissue and ⩽11% for bone ROIs. An implementation of the single torus source was filled with (18)F-fluorodeoxyglucose and the proposed method quantified for several test cases alone or in comparison with CT-derived μ-maps. A volume average of 0.095 cm(-1) was recorded for an experimental uniform cylinder phantom scan, while a bias of <2% was measured for the cortical bone equivalent insert of the multi-compartment phantom. Single torus μ-maps of a hip implant phantom showed significantly less artifacts and improved dynamic range, and differed greatly for highly attenuating materials in the case of the patient table, compared to CT results. Use of a fixed torus geometry, in combination with translation of the patient table to perform complete tomographic sampling, generated highly quantitative measured μ-maps and is expected to produce images with significantly higher SNR than competing fixed geometries at matched total acquisition time.
Transmission imaging for integrated PET-MR systems
NASA Astrophysics Data System (ADS)
Bowen, Spencer L.; Fuin, Niccolò; Levine, Michael A.; Catana, Ciprian
2016-08-01
Attenuation correction for PET-MR systems continues to be a challenging problem, particularly for body regions outside the head. The simultaneous acquisition of transmission scan based μ-maps and MR images on integrated PET-MR systems may significantly increase the performance of and offer validation for new MR-based μ-map algorithms. For the Biograph mMR (Siemens Healthcare), however, use of conventional transmission schemes is not practical as the patient table and relatively small diameter scanner bore significantly restrict radioactive source motion and limit source placement. We propose a method for emission-free coincidence transmission imaging on the Biograph mMR. The intended application is not for routine subject imaging, but rather to improve and validate MR-based μ-map algorithms; particularly for patient implant and scanner hardware attenuation correction. In this study we optimized source geometry and assessed the method’s performance with Monte Carlo simulations and phantom scans. We utilized a Bayesian reconstruction algorithm, which directly generates μ-map estimates from multiple bed positions, combined with a robust scatter correction method. For simulations with a pelvis phantom a single torus produced peak noise equivalent count rates (34.8 kcps) dramatically larger than a full axial length ring (11.32 kcps) and conventional rotating source configurations. Bias in reconstructed μ-maps for head and pelvis simulations was ⩽4% for soft tissue and ⩽11% for bone ROIs. An implementation of the single torus source was filled with 18F-fluorodeoxyglucose and the proposed method quantified for several test cases alone or in comparison with CT-derived μ-maps. A volume average of 0.095 cm-1 was recorded for an experimental uniform cylinder phantom scan, while a bias of <2% was measured for the cortical bone equivalent insert of the multi-compartment phantom. Single torus μ-maps of a hip implant phantom showed significantly less artifacts and improved dynamic range, and differed greatly for highly attenuating materials in the case of the patient table, compared to CT results. Use of a fixed torus geometry, in combination with translation of the patient table to perform complete tomographic sampling, generated highly quantitative measured μ-maps and is expected to produce images with significantly higher SNR than competing fixed geometries at matched total acquisition time.
Miniature X-Ray Bone Densitometer
NASA Technical Reports Server (NTRS)
Charles, Harry K., Jr.
1999-01-01
The purpose of the Dual Energy X-ray Absorptiometry (DEXA) project is to design, build, and test an advanced X-ray absorptiometry scanner capable of being used to monitor the deleterious effects of weightlessness on the human musculoskeletal system during prolonged spaceflight. The instrument is based on the principles of dual energy x-ray absorptiometry and is designed not only to measure bone, muscle, and fat masses but also to generate structural information about these tissues so that the effects on mechanical integrity may be assessed using biomechanical principles. A skeletal strength assessment could be particularly important for an astronaut embarking on a remote planet where the consequences of a fragility fracture may be catastrophic. The scanner will employ multiple projection images about the long axis of the scanned subject to provide geometric properties in three dimensions, suitable for a three-dimensional structural analysis of the scanned region. The instrument will employ advanced fabrication techniques to minimize volume and mass (100 kg current target with a long-term goal of 60 kg) of the scanner as appropriate for the space environment, while maintaining the required mechanical stability for high precision measurement. The unit will have the precision required to detect changes in bone mass and geometry as small as 1% and changes in muscle mass as small as 5%. As the system evolves, advanced electronic fabrication technologies such as chip-on-board and multichip modules will be combined with commercial (off-the-shelf) parts to produce a reliable, integrated system which not only minimizes size and weight, but, because of its simplicity, is also cost effective to build and maintain. Additionally, the system is being designed to minimize power consumption. Methods of heat dissipation and mechanical stowage (for the unit when not in use) are being optimized for the space environment.
NASA Astrophysics Data System (ADS)
Granton, Patrick V.; Dekker, Kurtis H.; Battista, Jerry J.; Jordan, Kevin J.
2016-04-01
Optical cone-beam computed tomographic (CBCT) scanning of 3D radiochromic dosimeters may provide a practical method for 3D dose verification in radiation therapy. However, in cone-beam geometry stray light contaminates the projection images, degrading the accuracy of reconstructed linear attenuation coefficients. Stray light was measured using a beam pass aperture array (BPA) and structured illumination methods. The stray-to-primary ray ratio (SPR) along the central axis was found to be 0.24 for a 5% gelatin hydrogel, representative of radiochromic hydrogels. The scanner was modified by moving the spectral filter from the detector to the source, changing the light’s spatial fluence pattern and lowering the acceptance angle by extending distance between the source and object. These modifications reduced the SPR significantly from 0.24 to 0.06. The accuracy of the reconstructed linear attenuation coefficients for uniform carbon black liquids was compared to independent spectrometer measurements. Reducing the stray light increased the range of accurate transmission readings. In order to evaluate scanner performance for the more challenging application to small field dosimetry, a carbon black finger gel phantom was prepared. Reconstructions of the phantom from CBCT and fan-beam CT scans were compared. The modified source resulted in improved agreement. Subtraction of residual stray light, measured with BPA or structured illumination from each projection further improved agreement. Structured illumination was superior to BPA for measuring stray light for the smaller 1.2 and 0.5 cm diameter phantom fingers. At the costs of doubling the scanner size and tripling the number of scans, CBCT reconstructions of low-scattering hydrogel dosimeters agreed with those of fan-beam CT scans.
Design and Development of a Megavoltage CT Scanner for Radiation Therapy.
NASA Astrophysics Data System (ADS)
Chen, Ching-Tai
A Varian 4 MeV isocentric therapy accelerator has been modified to perform also as a CT scanner. The goal is to provide low cost computed tomography capability for use in radiotherapy. The system will have three principal uses. These are (i) to provide 2- and 3-dimensional maps of electron density distribution for CT assisted therapy planning, (ii) to aid in patient set up by providing sectional views of the treatment volume and high contrast scout-mode verification images and (iii) to provide a means for periodically checking the patients anatomical conformation against what was used to generate the original therapy plan. The treatment machine was modified by mounting an array of detectors on a frame bolted to the counter weight end of the gantry in such a manner as to define a 'third generation' CT Scanner geometry. The data gathering is controlled by a Z-80 based microcomputer system which transfers the x-ray transmission data to a general purpose PDP 11/34 for processing. There a series of calibration processes and a logarithmic conversion are performed to get projection data. After reordering the projection data to an equivalent parallel beam sinogram format a convolution algorithm is employed to construct the image from the equivalent parallel projection data. Results of phantom studies have shown a spatial resolution of 2.6 mm and an electron density discrimination of less than 1% which are sufficiently good for accurate therapy planning. Results also show that the system is linear to within the precision of our measurement ((DBLTURN).75%) over a wide range of electron densities corresponding to those found in body tissues. Animal and human images are also presented to demonstrate that the system's imaging capability is sufficient to allow the necessary visualization of anatomy.
LOR-interleaving image reconstruction for PET imaging with fractional-crystal collimation
NASA Astrophysics Data System (ADS)
Li, Yusheng; Matej, Samuel; Karp, Joel S.; Metzler, Scott D.
2015-01-01
Positron emission tomography (PET) has become an important modality in medical and molecular imaging. However, in most PET applications, the resolution is still mainly limited by the physical crystal sizes or the detector’s intrinsic spatial resolution. To achieve images with better spatial resolution in a central region of interest (ROI), we have previously proposed using collimation in PET scanners. The collimator is designed to partially mask detector crystals to detect lines of response (LORs) within fractional crystals. A sequence of collimator-encoded LORs is measured with different collimation configurations. This novel collimated scanner geometry makes the reconstruction problem challenging, as both detector and collimator effects need to be modeled to reconstruct high-resolution images from collimated LORs. In this paper, we present a LOR-interleaving (LORI) algorithm, which incorporates these effects and has the advantage of reusing existing reconstruction software, to reconstruct high-resolution images for PET with fractional-crystal collimation. We also develop a 3D ray-tracing model incorporating both the collimator and crystal penetration for simulations and reconstructions of the collimated PET. By registering the collimator-encoded LORs with the collimator configurations, high-resolution LORs are restored based on the modeled transfer matrices using the non-negative least-squares method and EM algorithm. The resolution-enhanced images are then reconstructed from the high-resolution LORs using the MLEM or OSEM algorithm. For validation, we applied the LORI method to a small-animal PET scanner, A-PET, with a specially designed collimator. We demonstrate through simulated reconstructions with a hot-rod phantom and MOBY phantom that the LORI reconstructions can substantially improve spatial resolution and quantification compared to the uncollimated reconstructions. The LORI algorithm is crucial to improve overall image quality of collimated PET, which can have significant implications in preclinical and clinical ROI imaging applications.
Wu, Ed X.; Tang, Haiying; Tong, Christopher; Heymsfield, Steve B.; Vasselli, Joseph R.
2015-01-01
This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 Tesla scanner and quantitative image analysis was established and employed to measure the individual muscle and organ volumes in the intact and castrated guinea pigs undergoing a 16-week treatment protocol by two well-documented anabolic steroids, testosterone and nandrolone, via implanted silastic capsules. High correlations between the in vivo MRI and postmortem dissection measurements were observed for shoulder muscle complex (R = 0.86), masseter (R=0.79), temporalis (R=0.95), neck muscle complex (R=0.58), prostate gland and seminal vesicles (R=0.98), and testis (R=0.96). Furthermore, the longitudinal MRI measurements yielded adequate sensitivity to detect the restoration of growth to or towards normal in castrated guinea pigs by replacing circulating steroid levels to physiological or slightly higher levels, as expected. These results demonstrated that quantitative MRI using a standard clinical scanner provides accurate and sensitive measurement of individual muscles and organs, and this in vivo MRI protocol in conjunction with the castrated guinea pig model constitutes an effective platform to investigate the longitudinal and cross-sectional growth effects of other potential anabolic steroids. The quantitative MRI protocol developed can also be readily adapted for human studies on most clinical MRI scanner to investigate the anabolic steroid growth effects, or monitor the changes in individual muscle and organ volume and geometry following injury, strength training, neuromuscular disorders, and pharmacological or surgical interventions. PMID:18241900
Fan, Qiuyun; Nummenmaa, Aapo; Witzel, Thomas; Zanzonico, Roberta; Keil, Boris; Cauley, Stephen; Polimeni, Jonathan R; Tisdall, Dylan; Van Dijk, Koene R A; Buckner, Randy L; Wedeen, Van J; Rosen, Bruce R; Wald, Lawrence L
2014-11-01
One of the major goals of the NIH Blueprint Human Connectome Project was to map and quantify the white matter connections in the brain using diffusion tractography. Given the prevalence of complex white matter structures, the capability of resolving local white matter geometries with multiple crossings in the diffusion magnetic resonance imaging (dMRI) data is critical. Increasing b-value has been suggested for delineation of the finer details of the orientation distribution function (ODF). Although increased gradient strength and duration increase sensitivity to highly restricted intra-axonal water, gradient strength limitations require longer echo times (TE) to accommodate the increased diffusion encoding times needed to achieve a higher b-value, exponentially lowering the signal-to-noise ratio of the acquisition. To mitigate this effect, the MGH-USC Connectom scanner was built with 300 mT/m gradients, which can significantly reduce the TE of high b-value diffusion imaging. Here we report comparisons performed across b-values based on q-ball ODF metrics to investigate whether high b-value diffusion imaging on the Connectom scanner can improve resolving complex white matter structures. The q-ball ODF features became sharper as the b-value increased, with increased power fraction in higher order spherical harmonic series of the ODF and increased peak heights relative to the overall size of the ODF. Crossing structures were detected in an increasingly larger fraction of white matter voxels and the spatial distribution of two-way and three-way crossing structures was largely consistent with known anatomy. Results indicate that dMRI with high diffusion encoding on the Connectom system is a promising tool to better characterize, and ultimately understand, the underlying structural organization and motifs in the human brain.
NASA Astrophysics Data System (ADS)
Clough, Emily; Bell, Derek
2016-02-01
This letter presents a distributive environmental justice analysis of unconventional gas development in the area of Pennsylvania lying over the Marcellus Shale, the largest shale gas formation in play in the United States. The extraction of shale gas using unconventional wells, which are hydraulically fractured (fracking), has increased dramatically since 2005. As the number of wells has grown, so have concerns about the potential public health effects on nearby communities. These concerns make shale gas development an environmental justice issue. This letter examines whether the hazards associated with proximity to wells and the economic benefits of shale gas production are fairly distributed. We distinguish two types of distributive environmental justice: traditional and benefit sharing. We ask the traditional question: are there a disproportionate number of minority or low-income residents in areas near to unconventional wells in Pennsylvania? However, we extend this analysis in two ways: we examine income distribution and level of education; and we compare before and after shale gas development. This contributes to discussions of benefit sharing by showing how the income distribution of the population has changed. We use a binary dasymetric technique to remap the data from the 2000 US Census and the 2009-2013 American Communities Survey and combine that data with a buffer containment analysis of unconventional wells to compare the characteristics of the population living nearer to unconventional wells with those further away before and after shale gas development. Our analysis indicates that there is no evidence of traditional distributive environmental injustice: there is not a disproportionate number of minority or low-income residents in areas near to unconventional wells. However, our analysis is consistent with the claim that there is benefit sharing distributive environmental injustice: the income distribution of the population nearer to shale gas wells has not been transformed since shale gas development.
Fatty acid profile of unconventional oilseeds.
Sabikhi, Latha; Sathish Kumar, M H
2012-01-01
The continued increase in human population has resulted in the rise in the demand as well as the price of edible oils, leading to the search for alternative unconventional sources of oils, particularly in the developing countries. There are hundreds of un- or underexplored plant seeds rich in oil suitable for edible or industrial purposes. Many of them are rich in polyunsaturated essential fatty acids, which establish their utility as "healthy oils." Some agrowaste products such as rice bran have gained importance as a potential source of edible oil. Genetic modification has paved the way for increasing the oil yields and improving the fatty acid profiles of traditional as well as unconventional oilseeds. Single cell oils are also novel sources of edible oil. Some of these unconventional oils may have excellent potential for medicinal and therapeutic uses, even if their low oil contents do not promote commercial production as edible oils. Copyright © 2012 Elsevier Inc. All rights reserved.
Zechner, A; Stock, M; Kellner, D; Ziegler, I; Keuschnigg, P; Huber, P; Mayer, U; Sedlmayer, F; Deutschmann, H; Steininger, P
2016-11-21
Image guidance during highly conformal radiotherapy requires accurate geometric calibration of the moving components of the imager. Due to limited manufacturing accuracy and gravity-induced flex, an x-ray imager's deviation from the nominal geometrical definition has to be corrected for. For this purpose a ball bearing phantom applicable for nine degrees of freedom (9-DOF) calibration of a novel cone-beam computed tomography (CBCT) scanner was designed and validated. In order to ensure accurate automated marker detection, as many uniformly distributed markers as possible should be used with a minimum projected inter-marker distance of 10 mm. Three different marker distributions on the phantom cylinder surface were simulated. First, a fixed number of markers are selected and their coordinates are randomly generated. Second, the quasi-random method is represented by setting a constraint on the marker distances in the projections. The third approach generates the ball coordinates helically based on the Golden ratio, ϕ. Projection images of the phantom incorporating the CBCT scanner's geometry were simulated and analysed with respect to uniform distribution and intra-marker distance. Based on the evaluations a phantom prototype was manufactured and validated by a series of flexmap calibration measurements and analyses. The simulation with randomly distributed markers as well as the quasi-random approach showed an insufficient uniformity of the distribution over the detector area. The best compromise between uniform distribution and a high packing fraction of balls is provided by the Golden section approach. A prototype was manufactured accordingly. The phantom was validated for 9-DOF geometric calibrations of the CBCT scanner with independently moveable source and detector arms. A novel flexmap calibration phantom intended for 9-DOF was developed. The ball bearing distribution based on the Golden section was found to be highly advantageous. The phantom showed satisfying results for calibrations of the CBCT scanner and provides the basis for further flexmap correction and reconstruction developments.
Salmingo, Remel Alingalan; Tadano, Shigeru; Abe, Yuichiro; Ito, Manabu
2016-05-12
Treatment for severe scoliosis is usually attained when the scoliotic spine is deformed and fixed by implant rods. Investigation of the intraoperative changes of implant rod shape in three-dimensions is necessary to understand the biomechanics of scoliosis correction, establish consensus of the treatment, and achieve the optimal outcome. The objective of this study was to measure the intraoperative three-dimensional geometry and deformation of implant rod during scoliosis corrective surgery.A pair of images was obtained intraoperatively by the dual camera system before rotation and after rotation of rods during scoliosis surgery. The three-dimensional implant rod geometry before implantation was measured directly by the surgeon and after surgery using a CT scanner. The images of rods were reconstructed in three-dimensions using quintic polynomial functions. The implant rod deformation was evaluated using the angle between the two three-dimensional tangent vectors measured at the ends of the implant rod.The implant rods at the concave side were significantly deformed during surgery. The highest rod deformation was found after the rotation of rods. The implant curvature regained after the surgical treatment.Careful intraoperative rod maneuver is important to achieve a safe clinical outcome because the intraoperative forces could be higher than the postoperative forces. Continuous scoliosis correction was observed as indicated by the regain of the implant rod curvature after surgery.
Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory?
Gianfaldoni, Serena; Tchernev, Georgi; Lotti, Jacopo; Wollina, Uwe; Satolli, Francesca; Rovesti, Miriam; França, Katlein; Lotti, Torello
2018-01-25
The authors show a brief overview of the vitiligo's unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.
Fully 3D refraction correction dosimetry system.
Manjappa, Rakesh; Makki, S Sharath; Kumar, Rajesh; Vasu, Ram Mohan; Kanhirodan, Rajan
2016-02-21
The irradiation of selective regions in a polymer gel dosimeter results in an increase in optical density and refractive index (RI) at those regions. An optical tomography-based dosimeter depends on rayline path through the dosimeter to estimate and reconstruct the dose distribution. The refraction of light passing through a dose region results in artefacts in the reconstructed images. These refraction errors are dependant on the scanning geometry and collection optics. We developed a fully 3D image reconstruction algorithm, algebraic reconstruction technique-refraction correction (ART-rc) that corrects for the refractive index mismatches present in a gel dosimeter scanner not only at the boundary, but also for any rayline refraction due to multiple dose regions inside the dosimeter. In this study, simulation and experimental studies have been carried out to reconstruct a 3D dose volume using 2D CCD measurements taken for various views. The study also focuses on the effectiveness of using different refractive-index matching media surrounding the gel dosimeter. Since the optical density is assumed to be low for a dosimeter, the filtered backprojection is routinely used for reconstruction. We carry out the reconstructions using conventional algebraic reconstruction (ART) and refractive index corrected ART (ART-rc) algorithms. The reconstructions based on FDK algorithm for cone-beam tomography has also been carried out for comparison. Line scanners and point detectors, are used to obtain reconstructions plane by plane. The rays passing through dose region with a RI mismatch does not reach the detector in the same plane depending on the angle of incidence and RI. In the fully 3D scanning setup using 2D array detectors, light rays that undergo refraction are still collected and hence can still be accounted for in the reconstruction algorithm. It is found that, for the central region of the dosimeter, the usable radius using ART-rc algorithm with water as RI matched medium is 71.8%, an increase of 6.4% compared to that achieved using conventional ART algorithm. Smaller diameter dosimeters are scanned with dry air scanning by using a wide-angle lens that collects refracted light. The images reconstructed using cone beam geometry is seen to deteriorate in some planes as those regions are not scanned. Refraction correction is important and needs to be taken in to consideration to achieve quantitatively accurate dose reconstructions. Refraction modeling is crucial in array based scanners as it is not possible to identify refracted rays in the sinogram space.
DOT National Transportation Integrated Search
2011-03-01
The emergence of unconventional intersections in the traffic community has been motivated by the notion : of improving service quality with innovative control strategies, such as rerouting the turning movements : or flipping the paths of two traffic ...
Unconventional microfluidics: expanding the discipline.
Nawaz, Ahmad Ahsan; Mao, Xiaole; Stratton, Zackary S; Huang, Tony Jun
2013-04-21
Since its inception, the discipline of microfluidics has been harnessed for innovations in the biomedicine/chemistry fields-and to great effect. This success has had the natural side-effect of stereotyping microfluidics as a platform for medical diagnostics and miniaturized lab processes. But microfluidics has more to offer. And very recently, some researchers have successfully applied microfluidics to fields outside its traditional domains. In this Focus article, we highlight notable examples of such "unconventional" microfluidics applications (e.g., robotics, electronics). It is our hope that these early successes in unconventional microfluidics prompt further creativity, and inspire readers to expand the microfluidics discipline.
Scanlon, Bridget R; Reedy, Robert C; Male, Frank; Walsh, Mark
2017-09-19
The Permian Basin is being transformed by the "shale revolution" from a major conventional play to the world's largest unconventional play, but water management is critical in this semiarid region. Here we explore evolving issues associated with produced water (PW) management and hydraulic fracturing water demands based on detailed well-by-well analyses. Our results show that although conventional wells produce ∼13 times more water than oil (PW to oil ratio, PWOR = 13), this produced water has been mostly injected back into pressure-depleted oil-producing reservoirs for enhanced oil recovery. Unconventional horizontal wells use large volumes of water for hydraulic fracturing that increased by a factor of ∼10-16 per well and ∼7-10 if normalized by lateral well length (2008-2015). Although unconventional wells have a much lower PWOR of 3 versus 13 from conventional wells, this PW cannot be reinjected into the shale reservoirs but is disposed into nonproducing geologic intervals that could result in overpressuring and induced seismicity. The potential for PW reuse from unconventional wells is high because PW volumes can support hydraulic fracturing water demand based on 2014 data. Reuse of PW with minimal treatment (clean brine) can partially mitigate PW injection concerns while reducing water demand for hydraulic fracturing.
Investigation of a Combined Surveying and Scanning Device: The Trimble SX10 Scanning Total Station
Lachat, Elise; Landes, Tania; Grussenmeyer, Pierre
2017-01-01
Surveying fields from geosciences to infrastructure monitoring make use of a wide range of instruments for accurate 3D geometry acquisition. In many cases, the Terrestrial Laser Scanner (TLS) tends to become an optimal alternative to total station measurements thanks to the high point acquisition rate it offers, but also to ever deeper data processing software functionalities. Nevertheless, traditional surveying techniques are valuable in some kinds of projects. Nowadays, a few modern total stations combine their conventional capabilities with those of a laser scanner in a unique device. The recent Trimble SX10 scanning total station is a survey instrument merging high-speed 3D scanning and the capabilities of an image-assisted total station. In this paper this new instrument is introduced and first compared to state-of-the-art image-assisted total stations. The paper also addresses the topic of various laser scanning projects and the delivered point clouds are compared with those of other TLS. Directly and indirectly georeferenced projects have been carried out and are investigated in this paper, and a polygonal traverse is performed through a building. Comparisons with the results delivered by well-established survey instruments show the reliability of the Trimble SX10 for geodetic work as well as for scanning projects. PMID:28362319
NASA Astrophysics Data System (ADS)
Rössler, Erik; Mattea, Carlos; Stapf, Siegfried
2015-02-01
Low field Nuclear Magnetic Resonance increases the contrast of the longitudinal relaxation rate in many biological tissues; one prominent example is hyaline articular cartilage. In order to take advantage of this increased contrast and to profile the depth-dependent variations, high resolution parameter measurements are carried out which can be of critical importance in an early diagnosis of cartilage diseases such as osteoarthritis. However, the maximum achievable spatial resolution of parameter profiles is limited by factors such as sensor geometry, sample curvature, and diffusion limitation. In this work, we report on high-resolution single-sided NMR scanner measurements with a commercial device, and quantify these limitations. The highest achievable spatial resolution on the used profiler, and the lateral dimension of the sensitive volume were determined. Since articular cartilage samples are usually bent, we also focus on averaging effects inside the horizontally aligned sensitive volume and their impact on the relaxation profiles. Taking these critical parameters into consideration, depth-dependent relaxation time profiles with the maximum achievable vertical resolution of 20 μm are discussed, and are correlated with diffusion coefficient profiles in hyaline articular cartilage in order to reconstruct T2 maps from the diffusion-weighted CPMG decays of apparent relaxation rates.
3D acquisition and modeling for flint artefacts analysis
NASA Astrophysics Data System (ADS)
Loriot, B.; Fougerolle, Y.; Sestier, C.; Seulin, R.
2007-07-01
In this paper, we are interested in accurate acquisition and modeling of flint artefacts. Archaeologists needs accurate geometry measurements to refine their understanding of the flint artefacts manufacturing process. Current techniques require several operations. First, a copy of a flint artefact is reproduced. The copy is then sliced. A picture is taken for each slice. Eventually, geometric information is manually determined from the pictures. Such a technique is very time consuming, and the processing applied to the original, as well as the reproduced object, induces several measurement errors (prototyping approximations, slicing, image acquisition, and measurement). By using 3D scanners, we significantly reduce the number of operations related to data acquisition and completely suppress the prototyping step to obtain an accurate 3D model. The 3D models are segmented into sliced parts that are then analyzed. Each slice is then automatically fitted by mathematical representation. Such a representation offers several interesting properties: geometric features can be characterized (e.g. shapes, curvature, sharp edges, etc), and a shape of the original piece of stone can be extrapolated. The contributions of this paper are an acquisition technique using 3D scanners that strongly reduces human intervention, acquisition time and measurement errors, and the representation of flint artefacts as mathematical 2D sections that enable accurate analysis.
Schneider, Florian R; Mann, Alexander B; Konorov, Igor; Delso, Gaspar; Paul, Stephan; Ziegler, Sibylle I
2012-06-01
A one-day laboratory course on positron emission tomography (PET) for the education of physics students and PhD students in medical physics has been set up. In the course, the physical background and the principles of a PET scanner are introduced. Course attendees set the system in operation, calibrate it using a (22)Na point source and reconstruct different source geometries filled with (18)F. The PET scanner features an individual channel read-out of 96 lutetium oxyorthosilicate (LSO) scintillator crystals coupled to avalanche photodiodes (APD). The analog data of each APD are digitized by fast sampling analog to digital converters (SADC) and processed within field programmable gate arrays (FPGA) to extract amplitudes and time stamps. All SADCs are continuously sampling with a precise rate of 80MHz, which is synchronous for the whole system. The data is transmitted via USB to a Linux PC, where further processing and the image reconstruction are performed. The course attendees get an insight into detector techniques, modern read-out electronics, data acquisition and PET image reconstruction. In addition, a short introduction to some common software applications used in particle and high energy physics is part of the course. Copyright © 2011. Published by Elsevier GmbH.
NASA Astrophysics Data System (ADS)
Church, Philip; Borribanbunpotkat, Kiatchai; Trickey, Evan; Iles, Peter; Sekerka, Mike
2014-06-01
Neptec has developed a family of obscurant-penetrating 3D laser scanners called OPAL 2.0 that are being adapted for rotorcraft platforms. Neptec and Boeing have been working on an integrated system utilizing the OPAL LiDAR to support operations in degraded visual environments. OPAL scanners incorporate Neptec's patented obscurantpenetrating LiDAR technology which was extensively tested in controlled dust environments and helicopters for brownout mitigation. The OPAL uses a scanning mechanism based on the Risley prism pair. Data acquisition rates can go as high as 200kHz for ranges within 200m and 25kHz for ranges exceeding 200m. The scan patterns are created by the rotation of two prisms under independent motor control. The geometry and material properties of the prisms will define the conical field-of-view of the sensor, which can be set up to 120 degrees. Through detailed simulations and analysis of mission profiles, the system can be tailored for applications to rotorcrafts. Examples of scan patterns and control schemes based on these simulations will be provided along with data density predictions versus acquisition time for applicable DVE scenarios. Preliminary 3D data acquired in clear and obscurant conditions will be presented.
Liu, Jiaen; Zhang, Xiaotong; Van de Moortele, Pierre-Francois; Schmitter, Sebastian
2013-01-01
Electrical Property Tomography (EPT) is a recently developed noninvasive technology to image the electrical conductivity and permittivity of biological tissues at Larmor frequency in Magnetic Resonance (MR) scanners. The absolute phase of the complex radio-frequency (RF) magnetic field (B1) is necessary for electrical property calculation. However, due to the lack of practical methods to directly measure the absolute B1 phases, current EPT techniques have been achieved with B1 phase estimation based on certain assumptions on object anatomy, coil structure and/or electromagnetic wave behavior associated with the main magnetic field, limiting EPT from a larger variety of applications. In this study, using a multi-channel transmit/receive coil, the framework of a new general approach for EPT has been introduced, which is independent on the assumptions utilized in previous studies. Using a human head model with realistic geometry, a series of computer simulations at 7T were conducted to evaluate the proposed method under different noise levels. Results showed that the proposed method can be used to reconstruct the conductivity and permittivity images with noticeable accuracy and stability. The feasibility of this approach was further evaluated in a phantom experiment at 7T. PMID:23743673
D Building FAÇADE Reconstruction Using Handheld Laser Scanning Data
NASA Astrophysics Data System (ADS)
Sadeghi, F.; Arefi, H.; Fallah, A.; Hahn, M.
2015-12-01
3D The three dimensional building modelling has been an interesting topic of research for decades and it seems that photogrammetry methods provide the only economic means to acquire truly 3D city data. According to the enormous developments of 3D building reconstruction with several applications such as navigation system, location based services and urban planning, the need to consider the semantic features (such as windows and doors) becomes more essential than ever, and therefore, a 3D model of buildings as block is not any more sufficient. To reconstruct the façade elements completely, we employed the high density point cloud data that obtained from the handheld laser scanner. The advantage of the handheld laser scanner with capability of direct acquisition of very dense 3D point clouds is that there is no need to derive three dimensional data from multi images using structure from motion techniques. This paper presents a grammar-based algorithm for façade reconstruction using handheld laser scanner data. The proposed method is a combination of bottom-up (data driven) and top-down (model driven) methods in which, at first the façade basic elements are extracted in a bottom-up way and then they are served as pre-knowledge for further processing to complete models especially in occluded and incomplete areas. The first step of data driven modelling is using the conditional RANSAC (RANdom SAmple Consensus) algorithm to detect façade plane in point cloud data and remove noisy objects like trees, pedestrians, traffic signs and poles. Then, the façade planes are divided into three depth layers to detect protrusion, indentation and wall points using density histogram. Due to an inappropriate reflection of laser beams from glasses, the windows appear like holes in point cloud data and therefore, can be distinguished and extracted easily from point cloud comparing to the other façade elements. Next step, is rasterizing the indentation layer that holds the windows and doors information. After rasterization process, the morphological operators are applied in order to remove small irrelevant objects. Next, the horizontal splitting lines are employed to determine floors and vertical splitting lines are employed to detect walls, windows, and doors. The windows, doors and walls elements which are named as terminals are clustered during classification process. Each terminal contains a special property as width. Among terminals, windows and doors are named the geometry tiles in definition of the vocabularies of grammar rules. Higher order structures that inferred by grouping the tiles resulted in the production rules. The rules with three dimensional modelled façade elements constitute formal grammar that is named façade grammar. This grammar holds all the information that is necessary to reconstruct façades in the style of the given building. Thus, it can be used to improve and complete façade reconstruction in areas with no or limited sensor data. Finally, a 3D reconstructed façade model is generated that the accuracy of its geometry size and geometry position depends on the density of the raw point cloud.
Assessment of unconventional tight-gas resources of the Magallanes Basin Province, Chile, 2015
Schenk, Christopher J.; Charpentier, Ronald R.; Pitman, Janet K.; Tennyson, Marilyn E.; Brownfield, Michael E.; Gaswirth, Stephanie B.; Le, Phuong A.; Leathers-Miller, Heidi M.; Marra, Kristen R.
2016-01-20
Using a geology-based assessment methodology, the U.S. Geological Survey assessed a technically recoverable mean resource of 8.3 trillion cubic feet of unconventional tight gas in the Zona Glauconitica of the Magallanes Basin Province, Chile.
Unconventional eating practices and their health implications.
Hanning, R M; Zlotkin, S H
1985-04-01
The authors discuss a number of unconventional or faddist foods and eating practices and their health implications. Among the topics included are vegetarianism, Zen macrobiotic diets, fast foods, junk foods, megavitamins and their toxicity, health foods, fad diets in infancy, and elimination diets.
Tibbetts, Scott A; McClellan, Kelly B
2006-01-01
Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells. Although important, the absolute requirement for MHC Class Ia–dependent CD8 T cells for control of chronic virus infection has not been formally demonstrated. We show here that mice lacking MHC Class Ia molecules (Kb−/−xDb−/− mice) effectively control chronic γ-herpesvirus 68 (γHV68) infection via a robust expansion of β2-microglobulin (β2-m)-dependent, but CD1d-independent, unconventional CD8 T cells. These unconventional CD8 T cells expressed: (1) CD8αβ and CD3, (2) cell surface molecules associated with conventional effector/memory CD8 T cells, (3) TCRαβ with a significant Vβ4, Vβ3, and Vβ10 bias, and (4) the key effector cytokine interferon-γ (IFNγ). Unconventional CD8 T cells utilized a diverse TCR repertoire, and CDR3 analysis suggests that some of that repertoire may be utilized even in the presence of conventional CD8 T cells. This is the first demonstration to our knowledge that β2-m–dependent, but Class Ia–independent, unconventional CD8 T cells can efficiently control chronic virus infection, implicating a role for β2-n–dependent non-classical MHC molecules in control of chronic viral infection. We speculate that similar unconventional CD8 T cells may be able to control of other chronic viral infections, especially when viruses evade immunity by inhibiting generation of Class Ia–restricted T cells. PMID:16733540
DOE Office of Scientific and Technical Information (OSTI.GOV)
Nix, Andrew; Johnson, Derek; Heltzel, Robert
Researchers at the Center for Alternative Fuels, Engines, and Emissions (CAFEE) completed a multi-year program under DE-FE0013689 entitled, “Assessing Fugitive Methane Emissions Impact Using Natural Gas Engines in Unconventional Resource Development.” When drilling activity was high and industry sought to lower operating costs and reduce emissions they began investing in dual fuel and dedicated natural gas engines to power unconventional well equipment. From a review of literature we determined that the prime-movers (or major fuel consumers) of unconventional well development were the service trucks (trucking), horizontal drilling rig (drilling) engines, and hydraulic stimulation pump (fracturing) engines. Based on early findingsmore » from on-road studies we assessed that conversion of prime movers to operate on natural gas could contribute to methane emissions associated with unconventional wells. As such, we collected significant in-use activity data from service trucks and in-use activity, fuel consumption, and gaseous emissions data from drilling and fracturing engines. Our findings confirmed that conversion of the prime movers to operate as dual fuel or dedicated natural gas – created an additional source of methane emissions. While some gaseous emissions were decreased from implementation of these technologies – methane and CO 2 equivalent emissions tended to increase, especially for non-road engines. The increases were highest for dual fuel engines due to methane slip from the exhaust and engine crankcase. Dedicated natural gas engines tended to have lower exhaust methane emissions but higher CO 2 emissions due to lower efficiency. Therefore, investing in currently available natural gas technologies for prime movers will increase the greenhouse gas footprint of the unconventional well development industry.« less
Probing dimensionality using a simplified 4-probe method.
Kjeldby, Snorre B; Evenstad, Otto M; Cooil, Simon P; Wells, Justin W
2017-10-04
4-probe electrical measurements have been in existence for many decades. One of the most useful aspects of the 4-probe method is that it is not only possible to find the resistivity of a sample (independently of the contact resistances), but that it is also possible to probe the dimensionality of the sample. In theory, this is straightforward to achieve by measuring the 4-probe resistance as a function of probe separation. In practice, it is challenging to move all four probes with sufficient precision over the necessary range. Here, we present an alternative approach. We demonstrate that the dimensionality of the conductive path within a sample can be directly probed using a modified 4-probe method in which an unconventional geometry is exploited; three of the probes are rigidly fixed, and the position of only one probe is changed. This allows 2D and 3D (and other) contributions the to resistivity to be readily disentangled. The required experimental instrumentation can be vastly simplified relative to traditional variable spacing 4-probe instruments.
Mazzotta, E; Picca, R A; Malitesta, C; Piletsky, S A; Piletska, E V
2008-02-28
A voltammetric sensor for (-)-ephedrine has been prepared by a novel approach based on immobilisation of an imprinted polymer for ephedrine (MIPE) in an electrosynthesised polypyrrole (PPY) film. Composite films were grown potentiostatically at 1.0 V vs. Pt (QRE) on a glassy carbon electrode using an unconventional "upside-down" (UD) geometry for the three-electrode cell. As a consequence, a high MIP loading was obtained, as revealed by SEM. The sensor response was evaluated, after overoxidation of PPY matrix, by cyclic voltammetry after pre-concentration in a buffered solution of analyte in 0.5-3 mM concentration range. An ephedrine peak at approximately 0.9 V increasing with concentration and saturating at high concentrations was evident. PPY-modified electrode showed a response, which was distinctly lower than the MIP response for the same concentration of the template. The effect of potential interferences including compounds usually found in human fluids (ascorbic acid, uric acid, urea, glucose, sorbitol, glycine, dopamine) was examined.
NASA Astrophysics Data System (ADS)
Van De Ven, C. J. C.; Mumford, Kevin G.
2018-05-01
The study of gas-water mass transfer in porous media is important in many applications, including unconventional resource extraction, carbon storage, deep geological waste storage, and remediation of contaminated groundwater, all of which rely on an understanding of the fate and transport of free and dissolved gas. The novel visual technique developed in this study provided both quantitative and qualitative observations of gas-water mass transfer. Findings included interaction between free gas architecture and dissolved plume migration, plume geometry and longevity. The technique was applied to the injection of CO2 in source patterns expected for stray gas originating from oil and gas operations to measure dissolved phase concentrations of CO2 at high spatial and temporal resolutions. The data set is the first of its kind to provide high resolution quantification of gas-water dissolution, and will facilitate an improved understanding of the fundamental processes of gas movement and fate in these complex systems.
NASA Astrophysics Data System (ADS)
Yustin Kamah, Muhammad; Armando, Adilla; Larasati Rahmani, Dinda; Paramitha, Shabrina
2017-12-01
Geophysical methods such as gravity and magnetotelluric methods commonly used in conventional and unconventional energy exploration, notably for exploring geothermal prospect. They used to identify the subsurface geology structures which is estimated as a path of fluid flow. This study was conducted in Kamojang Geothermal Field with the aim of highlighting the volcanic lineament in West Java, precisely in Guntur-Papandayan chain where there are three geothermal systems. Kendang Fault has predominant direction NE-SW, identified by magnetotelluric techniques and gravity data processing techniques. Gravity techniques such as spectral analysis, derivative solutions, and Euler deconvolution indicate the type and geometry of anomaly. Magnetotelluric techniques such as inverse modeling and polar diagram are required to know subsurface resistivity charactersitics and major orientation. Furthermore, the result from those methods will be compared to geology information and some section of well data, which is sufficiently suitable. This research is very useful to trace out another potential development area.
Unconventional oil and gas: The role of politics and proximity
NASA Astrophysics Data System (ADS)
Schelly, Chelsea
2016-10-01
Political divisions are important in understanding public perceptions of unconventional oil and natural gas development, but so is proximity to drilling activities. New research highlights that, as geographical distance from development areas increases, political ideology becomes more influential in explaining diverging perceptions.
Energy-Water Modeling and Analysis | Energy Analysis | NREL
future electricity scenarios under cases of limited water availability and electricity sector impacts of Manufacturing Water Use The Water Intensity and Resource Impacts of Unconventional Hydrocarbon Development Impacts of Unconventional Hydrocarbon Development Life Cycle Harmonization Project (Water) Sample
Sumant, Anirudha V.; Divan, Ralu; Posada, Chrystian M.; Castano, Carlos H.; Grant, Edwin J.; Lee, Hyoung K.
2016-03-29
A source cold cathode field emission array (FEA) source based on ultra-nanocrystalline diamond (UNCD) field emitters. This system was constructed as an alternative for detection of obscured objects and material. Depending on the geometry of the given situation a flat-panel source can be used in tomography, radiography, or tomosynthesis. Furthermore, the unit can be used as a portable electron or X-ray scanner or an integral part of an existing detection system. UNCD field emitters show great field emission output and can be deposited over large areas as the case with carbon nanotube "forest" (CNT) cathodes. Furthermore, UNCDs have better mechanical and thermal properties as compared to CNT tips which further extend the lifetime of UNCD based FEA.
Enhancement of time images for photointerpretation
NASA Technical Reports Server (NTRS)
Gillespie, A. R.
1986-01-01
The Thermal Infrared Multispectral Scanner (TIMS) images consist of six channels of data acquired in bands between 8 and 12 microns, thus they contain information about both temperature and emittance. Scene temperatures are controlled by reflectivity of the surface, but also by its geometry with respect to the Sun, time of day, and other factors unrelated to composition. Emittance is dependent upon composition alone. Thus the photointerpreter may wish to enhance emittance information selectively. Because thermal emittances in real scenes vary but little, image data tend to be highly correlated along channels. Special image processing is required to make this information available for the photointerpreter. Processing includes noise removal, construction of model emittance images, and construction of false-color pictures enhanced by decorrelation techniques.
A Novel Approach For Ankle Foot Orthosis Developed By Three Dimensional Technologies
NASA Astrophysics Data System (ADS)
Belokar, R. M.; Banga, H. K.; Kumar, R.
2017-12-01
This study presents a novel approach for testing mechanical properties of medical orthosis developed by three dimensional (3D) technologies. A hand-held type 3D laser scanner is used for generating 3D mesh geometry directly from patient’s limb. Subsequently 3D printable orthotic design is produced from crude input model by means of Computer Aided Design (CAD) software. Fused Deposition Modelling (FDM) method in Additive Manufacturing (AM) technologies is used to fabricate the 3D printable Ankle Foot Orthosis (AFO) prototype in order to test the mechanical properties on printout. According to test results, printed Acrylonitrile Butadiene Styrene (ABS) AFO prototype has sufficient elasticity modulus and durability for patient-specific medical device manufactured by the 3D technologies.
NASA Astrophysics Data System (ADS)
Riviere, Nicolas; Ceolato, Romain; Hespel, Laurent
2014-10-01
Onera, the French aerospace lab, develops and models active imaging systems to understand the relevant physical phenomena affecting these systems performance. As a consequence, efforts have been done on the propagation of a pulse through the atmosphere and on target geometries and surface properties. These imaging systems must operate at night in all ambient illumination and weather conditions in order to perform strategic surveillance for various worldwide operations. We have implemented codes for 2D and 3D laser imaging systems. As we aim to image a scene in the presence of rain, snow, fog or haze, we introduce such light-scattering effects in our numerical models and compare simulated images with measurements provided by commercial laser scanners.
Induced unconventional superconductivity on the surface states of Bi2Te3 topological insulator.
Charpentier, Sophie; Galletti, Luca; Kunakova, Gunta; Arpaia, Riccardo; Song, Yuxin; Baghdadi, Reza; Wang, Shu Min; Kalaboukhov, Alexei; Olsson, Eva; Tafuri, Francesco; Golubev, Dmitry; Linder, Jacob; Bauch, Thilo; Lombardi, Floriana
2017-12-08
Topological superconductivity is central to a variety of novel phenomena involving the interplay between topologically ordered phases and broken-symmetry states. The key ingredient is an unconventional order parameter, with an orbital component containing a chiral p x + ip y wave term. Here we present phase-sensitive measurements, based on the quantum interference in nanoscale Josephson junctions, realized by using Bi 2 Te 3 topological insulator. We demonstrate that the induced superconductivity is unconventional and consistent with a sign-changing order parameter, such as a chiral p x + ip y component. The magnetic field pattern of the junctions shows a dip at zero externally applied magnetic field, which is an incontrovertible signature of the simultaneous existence of 0 and π coupling within the junction, inherent to a non trivial order parameter phase. The nano-textured morphology of the Bi 2 Te 3 flakes, and the dramatic role played by thermal strain are the surprising key factors for the display of an unconventional induced order parameter.
Hofstetter, Jasmin; del Cañizo, Carlos; Wagner, Hannes; ...
2015-10-15
Silicon wafers comprise approximately 40% of crystalline silicon module cost and represent an area of great technological innovation potential. Paradoxically, unconventional wafer-growth techniques have thus far failed to displace multicrystalline and Czochralski silicon, despite four decades of innovation. One of the shortcomings of most unconventional materials has been a persistent carrier lifetime deficit in comparison to established wafer technologies, which limits the device efficiency potential. In this perspective article, we review a defect-management framework that has proven successful in enabling millisecond lifetimes in kerfless and cast materials. Control of dislocations and slowly diffusing metal point defects during growth, coupled tomore » effective control of fast-diffusing species during cell processing, is critical to enable high cell efficiencies. As a result, to accelerate the pace of novel wafer development, we discuss approaches to rapidly evaluate the device efficiency potential of unconventional wafers from injection-dependent lifetime measurements.« less
O'Brien, Ed; Smith, Robert W
2018-06-01
People commonly lament the inability to re-experience familiar things as they were first experienced. Four experiments suggest that consuming familiar things in new ways can disrupt adaptation and revitalize enjoyment. Participants better enjoyed the same familiar food (Experiment 1), drink (Experiment 2), and video (Experiments 3a-3b) simply when re-experiencing the entity via unusual means (e.g., eating popcorn using chopsticks vs. hands). This occurs because unconventional methods invite an immersive "first-time" perspective on the consumption object: boosts in enjoyment were mediated by revitalized immersion into the consumption experience and were moderated by time such that they were strongest when using unconventional methods for the first time (Experiments 1-2); likewise, unconventional methods that actively disrupted immersion did not elicit the boost, despite being novel (Experiments 3a-3b). Before abandoning once-enjoyable entities, knowing to consume old things in new ways (vs. attaining new things altogether) might temporarily restore enjoyment and postpone wasteful replacement.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kuuskraa, V.A.; Brashear, J.P.; Doscher, T.M.
1978-10-01
This study was conducted to assist public decision-makers in selecting among many choices to obtain new gas supplies by addressing 2 questions: 1) how severe is the need for additional future supplies of natural gas, and what is the economic potential of providing part of future supply through enhanced recovery from unconventional natural gas resources. The study also serves to assist the DOE in designing a cost-effective R and D program to stimulate industry to recover this unconventional gas and to produce it sooner. Tight gas basins, Devonian shale, methane from coal seams, and methane from geopressured aquifers are considered.more » It is concluded that unconventional sources, already providing about 1 Tcf per year, could provide from 3 to 4 Tcf in 1985 and from 6 to 8 Tcf in 1990 (at $1.75 and $3.00 per Mcf, respectively). However, even with these additions to supply, gas supply is projected to remain below 1977 usage levels. (DLC)« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hofstetter, Jasmin; del Cañizo, Carlos; Wagner, Hannes
Silicon wafers comprise approximately 40% of crystalline silicon module cost and represent an area of great technological innovation potential. Paradoxically, unconventional wafer-growth techniques have thus far failed to displace multicrystalline and Czochralski silicon, despite four decades of innovation. One of the shortcomings of most unconventional materials has been a persistent carrier lifetime deficit in comparison to established wafer technologies, which limits the device efficiency potential. In this perspective article, we review a defect-management framework that has proven successful in enabling millisecond lifetimes in kerfless and cast materials. Control of dislocations and slowly diffusing metal point defects during growth, coupled tomore » effective control of fast-diffusing species during cell processing, is critical to enable high cell efficiencies. As a result, to accelerate the pace of novel wafer development, we discuss approaches to rapidly evaluate the device efficiency potential of unconventional wafers from injection-dependent lifetime measurements.« less
Feng, Zexin; Froese, Brittany D; Huang, Chih-Yu; Ma, Donglin; Liang, Rongguang
2015-07-10
We consider here creation of an unconventional flattop beam with a large depth of field by employing double freeform optical surfaces. The output beam is designed with continuous variations from the flattop to almost zero near the edges to resist the influence of diffraction on its propagation. We solve this challenging problem by naturally incorporating an optimal transport map computation scheme for unconventional boundary conditions with a simultaneous point-by-point double surface construction procedure. We demonstrate experimentally the generation of a long-range propagated triangular beam through a plano-freeform lens pair fabricated by a diamond-tuning machine.
Unconventional cancer remedies.
Danielson, K J; Stewart, D E; Lippert, G P
1988-01-01
Unproven and disproven remedies continue to abound for illnesses for which conventional treatment is only partially effective. This is particularly true with cancer, for which up to 50% of patients may be receiving unorthodox therapy. This article examines unconventional cancer remedies, their adverse effects, their common factors and the basis for their appeal, as well as what motivates and characterizes patients who choose these treatments. Also discussed is an approach that may be used by the conventional physician for patients who are likely to seek unorthodox treatment. This approach will help patients make the best decision about their treatment and protect them from the hazards of unconventional remedies. PMID:3285984
NASA Astrophysics Data System (ADS)
Singh, Manmohan; Han, Zhaolong; Nair, Achuth; Schill, Alexander; Twa, Michael D.; Larin, Kirill V.
2018-02-01
Screening for ocular diseases, such as glaucoma and keratoconus, includes measuring the eye-globe intraocular pressure (IOP) and corneal biomechanical properties. However, currently available clinical tools cannot quantify corneal tissue material parameters, which can provide critical information for detecting diseases and evaluating therapeutic outcomes. Here, we demonstrate measurement of eye-globe IOP, corneal elasticity, and corneal geometry of in situ porcine corneas with a technique termed applanation optical coherence elastography (Appl-OCE) with single instrument. We utilize an ultrafast phase-sensitive optical coherence tomography system comprised of a 4X buffered Fourier domain mode-locked swept source laser with an Ascan rate of 1.5 MHz and a 7.3 kHz resonant scanner. The IOP was measured by imaging the response of in situ porcine corneas to a large force air-puff. As with other noncontact tonometers, the time when the cornea was applanated during the inwards and outwards motion was correlated to a measure air-pressure temporal profile. The IOP was also measured with a commercially available rebound tonometer for comparison. The stiffness of the corneas was assessed by directly imaging and analyzing the propagation of a focused micro air-pulse induced elastic wave, and the corneal geometry was obtained from the OCT structural image. Our results show that corneal thickness decreased as IOP increased, and that corneal stiffness increased with IOP. Moreover, the IOP measurements made by Appl-OCE were more closely correlated with the artificially set IOP than the rebound tonometer, demonstrating the capabilities of Appl-OCE to measure corneal stiffness, eye-globe IOP, and corneal geometry with a single instrument.
NASA Technical Reports Server (NTRS)
Chatzimavroudis, George P.; Spirka, Thomas A.; Setser, Randolph M.; Myers, Jerry G.
2004-01-01
One of NASA's objectives is to be able to perform a complete, pre-flight, evaluation of cardiovascular changes in astronauts scheduled for prolonged space missions. Computational fluid dynamics (CFD) has shown promise as a method for estimating cardiovascular function during reduced gravity conditions. For this purpose, MRI can provide geometrical information, to reconstruct vessel geometries, and measure all spatial velocity components, providing location specific boundary conditions. The objective of this study was to investigate the reliability of MRI-based model reconstruction and measured boundary conditions for CFD simulations. An aortic arch model and a carotid bifurcation model were scanned in a 1.5T Siemens MRI scanner. Axial MRI acquisitions provided images for geometry reconstruction (slice thickness 3 and 5 mm; pixel size 1x1 and 0.5x0.5 square millimeters). Velocity acquisitions provided measured inlet boundary conditions and localized three-directional steady-flow velocity data (0.7-3.0 L/min). The vessel walls were isolated using NIH provided software (ImageJ) and lofted to form the geometric surface. Constructed and idealized geometries were imported into a commercial CFD code for meshing and simulation. Contour and vector plots of the velocity showed identical features between the MRI velocity data, the MRI-based CFD data, and the idealized-geometry CFD data, with less than 10% differences in the local velocity values. CFD results on models reconstructed from different MRI resolution settings showed insignificant differences (less than 5%). This study illustrated, quantitatively, that reliable CFD simulations can be performed with MRI reconstructed models and gives evidence that a future, subject-specific, computational evaluation of the cardiovascular system alteration during space travel is feasible.
NASA Astrophysics Data System (ADS)
Huerta, N. J.; Fahrman, B.; Rod, K. A.; Fernandez, C. A.; Crandall, D.; Moore, J.
2017-12-01
Laboratory experiments provide a robust method to analyze well integrity. Experiments are relatively cheap, controlled, and repeatable. However, simplifying assumptions, apparatus limitations, and scaling are ubiquitous obstacles for translating results from the bench to the field. We focus on advancing the correlation between laboratory results and field conditions by characterizing how failure varies with specimen geometry using two experimental approaches. The first approach is designed to measure the shear bond strength between steel and cement in a down-scaled (< 3" diameter) well geometry. We use several cylindrical casing-cement-casing geometries that either mimic the scaling ratios found in the field or maximize the amount of metal and cement in the sample. We subject the samples to thermal shock cycles to simulate damage to the interfaces from operations. The bond was then measured via a push-out test. We found that not only did expected parameters, e.g. curing time, play a role in shear-bond strength but also that scaling of the geometry was important. The second approach is designed to observe failure of the well system due to pressure applied on the inside of a lab-scale (1.5" diameter) cylindrical casing-cement-rock geometry. The loading apparatus and sample are housed within an industrial X-ray CT scanner capable of imaging the system while under pressure. Radial tension cracks were observed in the cement after an applied internal pressure of 3000 psi and propagated through the cement and into the rock as pressure was increased. Based on our current suite of tests we find that the relationship between sample diameters and thicknesses is an important consideration when observing the strength and failure of well systems. The test results contribute to our knowledge of well system failure, evaluation and optimization of new cements, as well as the applicability of using scaled-down tests as a proxy for understanding field-scale conditions.
2015-06-12
Unconventional Warfare, Cyberspace Operations, Cyber Warfare , Hacktivism, China, Russia, Georgia, Estonia, Umbrella Revolution, UW, Cyber, Guerilla, Hacktivist...6 Cyber Warfare ............................................................................................................. 7...Internet, and cyber warfare , the nature of the human element in cyberspace exhibits only a scientific advancement in the evolution of warfare, not a
Pollastro, Richard M.; Potter, Christopher J.; Schenk, Christopher J.; Charpentier, Ronald R.; Cook, Troy A.; Klett, Timothy R.; Kirschbaum, Mark A.
2012-01-01
The U.S. Geological Survey estimated a mean of 448 billion cubic feet of potential technically recoverable unconventional natural gas in Carboniferous and Permian coal-bearing strata in the eastern uplift of the Liaohe Basin, Liaoning Province, China.
2015-05-27
irregular threats. Unconventional Warfare (UW), traditionally a Special Operations Forces core activity, has served U.S. strategic interests in a variety...Special Operations Forces core activity, has served U.S. strategic interests in a variety of operational environments. Throughout the Cold War, the
This report describes the retrospective case study in north central Texas, conducted at three locations in Wise County where both conventional and unconventional gas production occurred in the past. Currently unconventional gas production occurs from the Mississippian-aged Barne...
Adolescents' Response to Unconventional War Threat Prior to the Gulf War.
ERIC Educational Resources Information Center
Klingman, Avigdor; Goldstein, Zehava
1994-01-01
Examined Israeli adolescents' responses to impending unconventional warfare by administering Nuclear Threat Index to 269 junior high school students 2 months prior to Persian Gulf War. Younger adolescents and females reported more activity, pessimistic thoughts, and concerns than older adolescents and males, respectively; and "internal"…
NASA Astrophysics Data System (ADS)
Wen, Gezheng; Park, Subok; Markey, Mia K.
2017-03-01
Multifocal and multicentric breast cancer (MFMC), i.e., the presence of two or more tumor foci within the same breast, has an immense clinical impact on treatment planning and survival outcomes. Detecting multiple breast tumors is challenging as MFMC breast cancer is relatively uncommon, and human observers do not know the number or locations of tumors a priori. Digital breast tomosynthesis (DBT), in which an x-ray beam sweeps over a limited angular range across the breast, has the potential to improve the detection of multiple tumors.1, 2 However, prior efforts to optimize DBT image quality only considered unifocal breast cancers (e.g.,3-9), so the recommended geometries may not necessarily yield images that are informative for the task of detecting MFMC. Hence, the goal of this study is to employ a 3D multi-lesion (ml) channelized-Hotelling observer (CHO) to identify optimal DBT acquisition geometries for MFMC. Digital breast phantoms and simulated DBT scanners of different geometries (e.g., wide or narrow arc scans, different number of projections in each scan) were used to generate image data for the simulation study. Multiple 3D synthetic lesions were inserted into different breast regions to simulate MF cases and MC cases. 3D partial least squares (PLS) channels, and 3D Laguerre-Gauss (LG) channels were estimated to capture discriminant information and correlations among signals in locally varying anatomical backgrounds, enabling the model observer to make both image-level and location-specific detection decisions. The 3D ml-CHO with PLS channels outperformed that with LG channels in this study. The simulated MC cases and MC cases were not equally difficult for the ml-CHO to detect across the different simulated DBT geometries considered in this analysis. Also, the results suggest that the optimal design of DBT may vary as the task of clinical interest changes, e.g., a geometry that is better for finding at least one lesion may be worse for counting the number of lesions.
NASA Astrophysics Data System (ADS)
Gigli, Giovanni; Margottini, Claudio; Spizzichino, Daniele; Ruther, Heinz; Casagli, Nicola
2016-04-01
Most classifications of mass movements in rock slopes use relatively simple, idealized geometries for the basal sliding surface, like planar sliding, wedge sliding, toppling or columnar failures. For small volumes, the real sliding surface can be often well described by such simple geometries. Extended and complex rock surfaces, however, can exhibit a large number of mass movements, also showing various kind of kinematisms. As a consequence, the real situation in large rock surfaces with a complicate geometry is generally very complex and a site depending analysis, such as fieldwork and compass, cannot be comprehensive of the real situation. Since the outstanding development of terrestrial laser scanner (TLS) in recent years, rock slopes can now be investigated and mapped through high resolution point clouds, reaching the resolution of few mm's and accuracy less than a cm in most advanced instruments, even from remote surveying. The availability of slope surface digital data can offer a unique chance to determine potential kinematisms in a wide distributed area for all the investigated geomorphological processes. More in detail the proposed method is based on the definition of least squares fitting planes on clusters of points extracted by moving a sampling cube on the point cloud. If the associated standard deviation is below a defined threshold, the cluster is considered valid. By applying geometric criteria it is possible to join all the clusters lying on the same surface; in this way discontinuity planes can be reconstructed, rock mass geometrical properties are calculated and, finally, potential kinematisms established. The Siq of Petra (Jordan), is a 1.2 km naturally formed gorge, with an irregular horizontal shape and a complex vertical slope, that represents the main entrance to Nabatean archaeological site. In the Siq, discontinuities of various type (bedding, joints, faults), mainly related to geomorphological evolution of the slope, lateral stress released, stratigraphic setting and tectonic activity can be recognized. As a consequence, rock-falls have been occurring, even recently, with unstable rock mass volumes ranging from 0.1 m3 up to over some hundreds m3. Slope instability, acceleration of crack deformation and consequent increasing of rock-fall hazard conditions, could threaten the safety of tourist as well as the integrity of the heritage. 3D surface model coming from Terrestrial Laser Scanner acquisitions was developed almost all over the site of Petra, including the Siq. Comprehensively, a point cloud of five billion points was generated making the site of Petra likely the largest scanned archaeological site in the word. As far as the Siq, the scanner was positioned on the path floor at intervals of not more than 10 meters from each station. The total number of scans in the Siq was 220 with an average point cloud interval of approximately 3 cm. Subsequently, for the definition of the main rockfall source areas, a spatial kinematic analysis for the whole Siq has been performed, by using discontinuity orientation data extracted from the point cloud by means of the software Diana. Orientation, number of sets, spacing/frequency, persistence, block size and scale dependent roughness was obtained combining fieldwork and automatic analysis. This kind of analysis is able to establish where a particular instability mechanism is kinematically feasible, given the geometry of the slope, the orientation of discontinuities and shear strength of the rock. The final outcome of this project was a detail landslide kinematic index map, reporting main potential instability mechanisms for a given area. The kinematic index was finally calibrated for each instability mechanism (plane failure; wedge failure; block toppling; flexural toppling) surveyed in the site. The latter is including the collapse occurred in May 2015, likely not producing any victim, in a sector clearly identified by the susceptibility maps produced by the analysis.
Model Development and Testing for THEMIS Controlled Mars Mosaics
NASA Technical Reports Server (NTRS)
Archinal, B. A.; Sides, S.; Weller, L.; Cushing, G.; Titus, T.; Kirk, R. L.; Soderblom, L. A.; Duxbury, T. C.
2005-01-01
As part of our work [1] to develop techniques and procedures to create regional and eventually global THEMIS mosaics of Mars, we are developing algorithms and software to photogrammetrically control THEMIS IR line scanner camera images. We have found from comparison of a limited number of images to MOLA digital image models (DIMs) [2] that the a priori geometry information (i.e. SPICE [3]) for THEMIS images generally allows their relative positions to be specified at the several pixel level (e.g. approx.5 to 13 pixels). However a need for controlled solutions to improve this geometry to the sub-pixel level still exists. Only with such solutions can seamless mosaics be obtained and likely distortion from spacecraft motion during image collection removed at such levels. Past experience has shown clearly that such mosaics are in heavy demand by users for operational and scientific use, and that they are needed over large areas or globally (as opposed to being available only on a limited basis via labor intensive custom mapping projects). Uses include spacecraft navigation, landing site planning and mapping, registration of multiple data types and image sets, registration of multispectral images, registration of images with topographic information, recovery of thermal properties, change detection searches, etc.
Castellazzi, Giovanni; D’Altri, Antonio Maria; Bitelli, Gabriele; Selvaggi, Ilenia; Lambertini, Alessandro
2015-01-01
In this paper, a new semi-automatic procedure to transform three-dimensional point clouds of complex objects to three-dimensional finite element models is presented and validated. The procedure conceives of the point cloud as a stacking of point sections. The complexity of the clouds is arbitrary, since the procedure is designed for terrestrial laser scanner surveys applied to buildings with irregular geometry, such as historical buildings. The procedure aims at solving the problems connected to the generation of finite element models of these complex structures by constructing a fine discretized geometry with a reduced amount of time and ready to be used with structural analysis. If the starting clouds represent the inner and outer surfaces of the structure, the resulting finite element model will accurately capture the whole three-dimensional structure, producing a complex solid made by voxel elements. A comparison analysis with a CAD-based model is carried out on a historical building damaged by a seismic event. The results indicate that the proposed procedure is effective and obtains comparable models in a shorter time, with an increased level of automation. PMID:26225978
Methods for CT automatic exposure control protocol translation between scanner platforms.
McKenney, Sarah E; Seibert, J Anthony; Lamba, Ramit; Boone, John M
2014-03-01
An imaging facility with a diverse fleet of CT scanners faces considerable challenges when propagating CT protocols with consistent image quality and patient dose across scanner makes and models. Although some protocol parameters can comfortably remain constant among scanners (eg, tube voltage, gantry rotation time), the automatic exposure control (AEC) parameter, which selects the overall mA level during tube current modulation, is difficult to match among scanners, especially from different CT manufacturers. Objective methods for converting tube current modulation protocols among CT scanners were developed. Three CT scanners were investigated, a GE LightSpeed 16 scanner, a GE VCT scanner, and a Siemens Definition AS+ scanner. Translation of the AEC parameters such as noise index and quality reference mAs across CT scanners was specifically investigated. A variable-diameter poly(methyl methacrylate) phantom was imaged on the 3 scanners using a range of AEC parameters for each scanner. The phantom consisted of 5 cylindrical sections with diameters of 13, 16, 20, 25, and 32 cm. The protocol translation scheme was based on matching either the volumetric CT dose index or image noise (in Hounsfield units) between two different CT scanners. A series of analytic fit functions, corresponding to different patient sizes (phantom diameters), were developed from the measured CT data. These functions relate the AEC metric of the reference scanner, the GE LightSpeed 16 in this case, to the AEC metric of a secondary scanner. When translating protocols between different models of CT scanners (from the GE LightSpeed 16 reference scanner to the GE VCT system), the translation functions were linear. However, a power-law function was necessary to convert the AEC functions of the GE LightSpeed 16 reference scanner to the Siemens Definition AS+ secondary scanner, because of differences in the AEC functionality designed by these two companies. Protocol translation on the basis of quantitative metrics (volumetric CT dose index or measured image noise) is feasible. Protocol translation has a dependency on patient size, especially between the GE and Siemens systems. Translation schemes that preserve dose levels may not produce identical image quality. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.
Mechanics and Activation of Unconventional Myosins.
Batters, Christopher; Veigel, Claudia
2016-08-01
Many types of cellular motility are based on the myosin family of motor proteins ranging from muscle contraction to exo- and endocytosis, cytokinesis, cell locomotion or signal transduction in hearing. At the center of this wide range of motile processes lies the adaptation of the myosins for each specific mechanical task and the ability to coordinate the timing of motor protein mobilization and targeting. In recent years, great progress has been made in developing single molecule technology to characterize the diverse mechanical properties of the unconventional myosins. Here, we discuss the basic mechanisms and mechanical adaptations of unconventional myosins, and emerging principles regulating motor mobilization and targeting. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Shimizu, Sakura; Shinya, Akikazu; Kuroda, Soichi; Gomi, Harunori
2017-07-26
The accuracy of prostheses affects clinical success and is, in turn, affected by the accuracy of the scanner and CAD programs. Thus, their accuracy is important. The first aim of this study was to evaluate the accuracy of an intraoral scanner with active triangulation (Cerec Omnicam), an intraoral scanner with a confocal laser (3Shape Trios), and an extraoral scanner with active triangulation (D810). The second aim of this study was to compare the accuracy of the digital crowns designed with two different scanner/CAD combinations. The accuracy of the intraoral scanners and extraoral scanner was clinically acceptable. Marginal and internal fit of the digital crowns fabricated using the intraoral scanner and CAD programs were inferior to those fabricated using the extraoral scanner and CAD programs.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-11
... for OMB Review; Comment Request; Requests To Approve Conformed Wage Classifications and Unconventional... Classifications and Unconventional Fringe Benefit Plans Under the Davis-Bacon and Related Acts and Contract Work... collection consist of: (A) Reports of conformed classifications and wage rates and (B) requests for approval...
Assessment of undiscovered oil and gas resources of the Paris Basin, France, 2015
Schenk, Christopher J.; Charpentier, Ronald R.; Klett, Timothy R.; Tennyson, Marilyn E.; Mercier, Tracey J.; Le, Phoung A.; Brownfield, Michael E.; Pitman, Janet K.; Gaswirth, Stephanie B.; Marra, Kristen R.; Leathers, Heidi M.
2015-01-01
Using a geology-based assessment methodology, the U.S. Geological Survey estimated means of 222 million barrels of unconventional oil; 2,092 billion cubic feet of unconventional gas; 18 million barrels of conventional oil; and 47 billion cubic feet of conventional gas resources in the Paris Basin of France.
Aspects of a Neoteric Approach to Advance Students' Ability to Conjecture, Prove, or Disprove
ERIC Educational Resources Information Center
McLoughlin, M. Padraig M. M.
2010-01-01
The author of this paper suggests several neoteric, unconventional, idiosyncratic, or unique approaches to beginning Set Theory that he found seems to work well in building students' introductory understanding of the Foundations of Mathematics. This paper offers some ideas on how the author uses certain "unconventional" definitions and…
Unconventional topological Hall effect in skyrmion crystals caused by the topology of the lattice
NASA Astrophysics Data System (ADS)
Göbel, Börge; Mook, Alexander; Henk, Jürgen; Mertig, Ingrid
2017-03-01
The hallmark of a skyrmion crystal (SkX) is the topological Hall effect (THE). In this article we predict and explain an unconventional behavior of the topological Hall conductivity in SkXs. In simple terms, the spin texture of the skyrmions causes an inhomogeneous emergent magnetic field whose associated Lorentz force acts on the electrons. By making the emergent field homogeneous, the THE is mapped onto the quantum Hall effect (QHE). Consequently, each electronic band of the SkX is assigned to a Landau level. This correspondence of THE and QHE allows us to explain the unconventional behavior of the THE of electrons in SkXs. For example, a skyrmion crystal on a triangular lattice exhibits a quantized topological Hall conductivity with steps of 2 .e2/h below and with steps of 1 .e2/h above the van Hove singularity. On top of this, the conductivity shows a prominent sign change at the van Hove singularity. These unconventional features are deeply connected to the topology of the structural lattice.
Swami, Viren; Weis, Laura; Barron, David; Furnham, Adrian
2017-11-01
While studies have documented robust relationships between body image and sexual health outcomes, few studies have looked beyond sexual functioning in women. Here, we hypothesized that more positive body image would be associated with greater sexual liberalism and more positive attitudes toward unconventional sexual practices. An online sample of 151 women and 164 men from the U.S. completed measures of sexual liberalism, attitudes toward unconventional sexual practices, and indices of positive body image (i.e., body appreciation, body acceptance by others, body image flexibility, and body pride), and provided their demographic details. Regression analyses indicated that, once the effects of sexual orientation, relationship status, age, and body mass index had been accounted for, higher body appreciation was significantly associated with greater sexual liberalism in women and men. Furthermore, higher body appreciation and body image flexibility were significantly associated with more positive attitudes toward unconventional sexual practices in women and men. These results may have implications for scholars working from a sex-positive perspective, particularly in terms of understanding the role body image plays in sexual attitudes and behaviors.
Occurrence and characteristics of mutual interference between LIDAR scanners
NASA Astrophysics Data System (ADS)
Kim, Gunzung; Eom, Jeongsook; Park, Seonghyeon; Park, Yongwan
2015-05-01
The LIDAR scanner is at the heart of object detection of the self-driving car. Mutual interference between LIDAR scanners has not been regarded as a problem because the percentage of vehicles equipped with LIDAR scanners was very rare. With the growing number of autonomous vehicle equipped with LIDAR scanner operated close to each other at the same time, the LIDAR scanner may receive laser pulses from other LIDAR scanners. In this paper, three types of experiments and their results are shown, according to the arrangement of two LIDAR scanners. We will show the probability that any LIDAR scanner will interfere mutually by considering spatial and temporal overlaps. It will present some typical mutual interference scenario and report an analysis of the interference mechanism.
Modeling the Relative GHG Emissions of Conventional and Shale Gas Production
2011-01-01
Recent reports show growing reserves of unconventional gas are available and that there is an appetite from policy makers, industry, and others to better understand the GHG impact of exploiting reserves such as shale gas. There is little publicly available data comparing unconventional and conventional gas production. Existing studies rely on national inventories, but it is not generally possible to separate emissions from unconventional and conventional sources within these totals. Even if unconventional and conventional sites had been listed separately, it would not be possible to eliminate site-specific factors to compare gas production methods on an equal footing. To address this difficulty, the emissions of gas production have instead been modeled. In this way, parameters common to both methods of production can be held constant, while allowing those parameters which differentiate unconventional gas and conventional gas production to vary. The results are placed into the context of power generation, to give a ″well-to-wire″ (WtW) intensity. It was estimated that shale gas typically has a WtW emissions intensity about 1.8–2.4% higher than conventional gas, arising mainly from higher methane releases in well completion. Even using extreme assumptions, it was found that WtW emissions from shale gas need be no more than 15% higher than conventional gas if flaring or recovery measures are used. In all cases considered, the WtW emissions of shale gas powergen are significantly lower than those of coal. PMID:22085088
Modeling the relative GHG emissions of conventional and shale gas production.
Stephenson, Trevor; Valle, Jose Eduardo; Riera-Palou, Xavier
2011-12-15
Recent reports show growing reserves of unconventional gas are available and that there is an appetite from policy makers, industry, and others to better understand the GHG impact of exploiting reserves such as shale gas. There is little publicly available data comparing unconventional and conventional gas production. Existing studies rely on national inventories, but it is not generally possible to separate emissions from unconventional and conventional sources within these totals. Even if unconventional and conventional sites had been listed separately, it would not be possible to eliminate site-specific factors to compare gas production methods on an equal footing. To address this difficulty, the emissions of gas production have instead been modeled. In this way, parameters common to both methods of production can be held constant, while allowing those parameters which differentiate unconventional gas and conventional gas production to vary. The results are placed into the context of power generation, to give a ″well-to-wire″ (WtW) intensity. It was estimated that shale gas typically has a WtW emissions intensity about 1.8-2.4% higher than conventional gas, arising mainly from higher methane releases in well completion. Even using extreme assumptions, it was found that WtW emissions from shale gas need be no more than 15% higher than conventional gas if flaring or recovery measures are used. In all cases considered, the WtW emissions of shale gas powergen are significantly lower than those of coal.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Andraka, Bohdan
2015-05-14
The main goal of this program was to explore the possibility of novel states and behaviors in Pr-based system exhibiting quantum critical behavior, PrOs₄Sb₁₂. Upon small changes of external parameter, such as magnetic field, physical properties of PrOs₄Sb₁₂ are drastically altered from those corresponding to a superconductor, to heavy fermion, to field-induced ordered phase with primary quadrupolar order parameter. All these states are highly unconventional and not understood in terms of current theories thus offer an opportunity to expand our knowledge and understanding of condensed matter. At the same time, these novel states and behaviors are subjects to intense internationalmore » controversies. In particular, two superconducting phases with different transition temperatures were observed in some samples and not observed in others leading to speculations that sample defects might be partially responsible for these exotic behaviors. This work clearly established that crystal disorder is important consideration, but contrary to current consensus this disorder suppresses exotic behavior. Superconducting properties imply unconventional inhomogeneous state that emerges from unconventional homogeneous normal state. Comprehensive structural investigations demonstrated that upper superconducting transition is intrinsic, bulk, and unconventional. The high quality of in-house synthesized single crystals was indirectly confirmed by de Haas-van Alphen quantum oscillation measurements. These measurements, for the first time ever reported, spanned several different phases, offering unprecedented possibility of studying quantum oscillations across phase boundaries.« less
Unconventional therapies for cancer: 1. Essiac
Kaegi, E
1998-01-01
Physicians and patients have been frustrated by the lack of reliable information on unconventional therapies. To help fill this gap in the area of breast cancer therapy, the Canadian Breast Cancer Research Initiative formed a task force to advise it on how best to promote research into unconventional therapies. As part of the work of the task force, a review of the available literature was carried out for each of the following products: Essiac, green tea, Iscador, hydrazine sulfate, vitamins A, C and E, and 714-X. The first article in this series on unconventional therapies for cancer describes the methodology used to obtain and evaluate the information and provides a summary of the findings on Essiac. Subsequent articles will cover the other products. For most of the products reviewed, there has been some indication of possible benefit but no definitive evidence. Innovative and collaborative research needed to meet the information needs of growing numbers of patients and their physicians is now being sponsored by the Canadian Breast Cancer Research Initiative. Open communication between patients and physicians is also necessary for the maintenance of an appropriate therapeutic partnership and for the identification and control of side effects. The Ontario Division of the Canadian Cancer Society, a partner in the Canadian Breast Cancer Research Initiative, supported the preparation of a patient-information piece on unconventional therapies to accompany the series. This item will assist patients who are considering such therapies and will promote open communication between patients and their physicians. PMID:9559016
Maloney, Kelly O; Baruch-Mordo, Sharon; Patterson, Lauren A; Nicot, Jean-Philippe; Entrekin, Sally A; Fargione, Joseph E; Kiesecker, Joseph M; Konschnik, Kate E; Ryan, Joseph N; Trainor, Anne M; Saiers, James E; Wiseman, Hannah J
2017-03-01
Extraction of oil and gas from unconventional sources, such as shale, has dramatically increased over the past ten years, raising the potential for spills or releases of chemicals, waste materials, and oil and gas. We analyzed spill data associated with unconventional wells from Colorado, New Mexico, North Dakota and Pennsylvania from 2005 to 2014, where we defined unconventional wells as horizontally drilled into an unconventional formation. We identified materials spilled by state and for each material we summarized frequency, volumes and spill rates. We evaluated the environmental risk of spills by calculating distance to the nearest stream and compared these distances to existing setback regulations. Finally, we summarized relative importance to drinking water in watersheds where spills occurred. Across all four states, we identified 21,300 unconventional wells and 6622 reported spills. The number of horizontal well bores increased sharply beginning in the late 2000s; spill rates also increased for all states except PA where the rate initially increased, reached a maximum in 2009 and then decreased. Wastewater, crude oil, drilling waste, and hydraulic fracturing fluid were the materials most often spilled; spilled volumes of these materials largely ranged from 100 to 10,000L. Across all states, the average distance of spills to a stream was highest in New Mexico (1379m), followed by Colorado (747m), North Dakota (598m) and then Pennsylvania (268m), and 7.0, 13.3, and 20.4% of spills occurred within existing surface water setback regulations of 30.5, 61.0, and 91.4m, respectively. Pennsylvania spills occurred in watersheds with a higher relative importance to drinking water than the other three states. Results from this study can inform risk assessments by providing improved input parameters on volume and rates of materials spilled, and guide regulations and the management policy of spills. Published by Elsevier B.V.
Maloney, Kelly O.; Baruch-Mordo, Sharon; Patterson, Lauren A.; Nicot, Jean-Philippe; Entrekin, Sally; Fargione, Joe E.; Kiesecker, Joseph M.; Konschnik, Kate E.; Ryan, Joseph N.; Trainor, Anne M.; Saiers, James E.; Wiseman, Hannah J.
2017-01-01
Extraction of oil and gas from unconventional sources, such as shale, has dramatically increased over the past ten years, raising the potential for spills or releases of chemicals, waste materials, and oil and gas. We analyzed spill data associated with unconventional wells from Colorado, New Mexico, North Dakota and Pennsylvania from 2005 to 2014, where we defined unconventional wells as horizontally drilled into an unconventional formation. We identified materials spilled by state and for each material we summarized frequency, volumes and spill rates. We evaluated the environmental risk of spills by calculating distance to the nearest stream and compared these distances to existing setback regulations. Finally, we summarized relative importance to drinking water in watersheds where spills occurred. Across all four states, we identified 21,300 unconventional wells and 6622 reported spills. The number of horizontal well bores increased sharply beginning in the late 2000s; spill rates also increased for all states except PA where the rate initially increased, reached a maximum in 2009 and then decreased. Wastewater, crude oil, drilling waste, and hydraulic fracturing fluid were the materials most often spilled; spilled volumes of these materials largely ranged from 100 to 10,000 L. Across all states, the average distance of spills to a stream was highest in New Mexico (1379 m), followed by Colorado (747 m), North Dakota (598 m) and then Pennsylvania (268 m), and 7.0, 13.3, and 20.4% of spills occurred within existing surface water setback regulations of 30.5, 61.0, and 91.4 m, respectively. Pennsylvania spills occurred in watersheds with a higher relative importance to drinking water than the other three states. Results from this study can inform risk assessments by providing improved input parameters on volume and rates of materials spilled, and guide regulations and the management policy of spills.
a Method for the Registration of Hemispherical Photographs and Tls Intensity Images
NASA Astrophysics Data System (ADS)
Schmidt, A.; Schilling, A.; Maas, H.-G.
2012-07-01
Terrestrial laser scanners generate dense and accurate 3D point clouds with minimal effort, which represent the geometry of real objects, while image data contains texture information of object surfaces. Based on the complementary characteristics of both data sets, a combination is very appealing for many applications, including forest-related tasks. In the scope of our research project, independent data sets of a plain birch stand have been taken by a full-spherical laser scanner and a hemispherical digital camera. Previously, both kinds of data sets have been considered separately: Individual trees were successfully extracted from large 3D point clouds, and so-called forest inventory parameters could be determined. Additionally, a simplified tree topology representation was retrieved. From hemispherical images, leaf area index (LAI) values, as a very relevant parameter for describing a stand, have been computed. The objective of our approach is to merge a 3D point cloud with image data in a way that RGB values are assigned to each 3D point. So far, segmentation and classification of TLS point clouds in forestry applications was mainly based on geometrical aspects of the data set. However, a 3D point cloud with colour information provides valuable cues exceeding simple statistical evaluation of geometrical object features and thus may facilitate the analysis of the scan data significantly.
NASA Astrophysics Data System (ADS)
Fu, Wanyi; Sturgeon, Gregory M.; Agasthya, Greeshma; Segars, W. Paul; Kapadia, Anuj J.; Samei, Ehsan
2017-03-01
This study aimed to estimate the organ dose reduction potential for organ-dose-based tube current modulated (ODM) thoracic CT with wide dose reduction arc. Twenty-one computational anthropomorphic phantoms (XCAT, age range: 27- 75 years, weight range: 52.0-105.8 kg) were used to create a virtual patient population with clinical anatomic variations. For each phantom, two breast tissue compositions were simulated: 50/50 and 20/80 (glandular-to-adipose ratio). A validated Monte Carlo program was used to estimate the organ dose for standard tube current modulation (TCM) (SmartmA, GE Healthcare) and ODM (GE Healthcare) for a commercial CT scanner (Revolution, GE Healthcare) with explicitly modeled tube current modulation profile, scanner geometry, bowtie filtration, and source spectrum. Organ dose was determined using a typical clinical thoracic CT protocol. Both organ dose and CTDIvol-to-organ dose conversion coefficients (h factors) were compared between TCM and ODM. ODM significantly reduced all radiosensitive organ doses (p<0.01). The breast dose was reduced by 30+/-2%. For h factors, organs in the anterior region (e.g. thyroid, stomach) exhibited substantial decreases, and the medial, distributed, and posterior region either saw an increase or no significant change. The organ-dose-based tube current modulation significantly reduced organ doses especially for radiosensitive superficial anterior organs such as the breasts.
Rössler, Erik; Mattea, Carlos; Stapf, Siegfried
2015-02-01
Low field Nuclear Magnetic Resonance increases the contrast of the longitudinal relaxation rate in many biological tissues; one prominent example is hyaline articular cartilage. In order to take advantage of this increased contrast and to profile the depth-dependent variations, high resolution parameter measurements are carried out which can be of critical importance in an early diagnosis of cartilage diseases such as osteoarthritis. However, the maximum achievable spatial resolution of parameter profiles is limited by factors such as sensor geometry, sample curvature, and diffusion limitation. In this work, we report on high-resolution single-sided NMR scanner measurements with a commercial device, and quantify these limitations. The highest achievable spatial resolution on the used profiler, and the lateral dimension of the sensitive volume were determined. Since articular cartilage samples are usually bent, we also focus on averaging effects inside the horizontally aligned sensitive volume and their impact on the relaxation profiles. Taking these critical parameters into consideration, depth-dependent relaxation time profiles with the maximum achievable vertical resolution of 20 μm are discussed, and are correlated with diffusion coefficient profiles in hyaline articular cartilage in order to reconstruct T(2) maps from the diffusion-weighted CPMG decays of apparent relaxation rates. Copyright © 2014 Elsevier Inc. All rights reserved.
Optical Breast Shape Capture and Finite Element Mesh Generation for Electrical Impedance Tomography
Forsyth, J.; Borsic, A.; Halter, R.J.; Hartov, A.; Paulsen, K.D.
2011-01-01
X-Ray mammography is the standard for breast cancer screening. The development of alternative imaging modalities is desirable because Mammograms expose patients to ionizing radiation. Electrical Impedance Tomography (EIT) may be used to determine tissue conductivity, a property which is an indicator of cancer presence. EIT is also a low-cost imaging solution and does not involve ionizing radiation. In breast EIT, impedance measurements are made using electrodes placed on the surface of the patient’s breast. The complex conductivity of the volume of the breast is estimated by a reconstruction algorithm. EIT reconstruction is a severely ill-posed inverse problem. As a result, noisy instrumentation and incorrect modelling of the electrodes and domain shape produce significant image artefacts. In this paper, we propose a method that has the potential to reduce these errors by accurately modelling the patient breast shape. A 3D hand-held optical scanner is used to acquire the breast geometry and electrode positions. We develop methods for processing the data from the scanner and producing volume meshes accurately matching the breast surface and electrode locations, which can be used for image reconstruction. We demonstrate this method for a plaster breast phantom and a human subject. Using this approach will allow patient-specific finite element meshes to be generated which has the potential to improve the clinical value of EIT for breast cancer diagnosis. PMID:21646711
Replicas in Cultural Heritage: 3d Printing and the Museum Experience
NASA Astrophysics Data System (ADS)
Ballarin, M.; Balletti, C.; Vernier, P.
2018-05-01
3D printing has seen a recent massive diffusion for several applications, not least the field of Cultural Heritage. Being used for different purposes, such as study, analysis, conservation or access in museum exhibitions, 3D printed replicas need to undergo a process of validation also in terms of metrical precision and accuracy. The Laboratory of Photogrammetry of Iuav University of Venice has started several collaborations with Italian museum institutions firstly for the digital acquisition and then for the physical reproduction of objects of historical and artistic interest. The aim of the research is to analyse the metric characteristics of the printed model in relation to the original data, and to optimize the process that from the survey leads to the physical representation of an object. In fact, this could be acquired through different methodologies that have different precisions (multi-image photogrammetry, TOF laser scanner, triangulation based laser scanner), and it always involves a long processing phase. It should not be forgotten that the digital data have to undergo a series of simplifications, which, on one hand, eliminate the noise introduced by the acquisition process, but on the other one, they can lead to discrepancies between the physical copy and the original geometry. In this paper we will show the results obtained on a small archaeological find that was acquired and reproduced for a museum exhibition intended for blind and partially sighted people.
Shape and Construction of Brick Vaults. Criteria, Methods and Tools for a Possible Catalogue
NASA Astrophysics Data System (ADS)
Brumana, R.; Condoleo, P.; Grimoldi, A.; Landi, A. G.
2017-05-01
The use of cloister vaults in the construction of noble buildings, as covering elements for square or rectangular rooms, is widespread and well-known. The geometric continuity at the intrados makes generally possible the execution all over the span of frescoes, stucco and decorations. The construction of brick vaults, from the late Middle Age, was sped up by limiting the centering to the wooden planks arches that were instrumental in the profile determination. Nowadays, the availability of several procedures, phases and tools for carrying out a survey allows to draw reliable assumptions about the construction methods and the execution time. It is mandatory to determine the properties of the binders, the shape and dimensions of the bricks, and to carry out a comparison between the geometry of the intrados surface and the evidences emerging at the extrados. The support of the laser scanner technique allows to accurately identify the surface profile and thickness. All these indications, in turn, are useful, in view of an interpretation of the structural behavior, to identify weaknesses, and to highlight contributing factors of instability (if any). The paper focuses on a well-documented case, the Magio Grasselli palace in Cremona in which the cloister vaults of two main rooms show different construction systems, although they were built almost at the same time. The thermographic recordings and laser-scanner surveys highlight the various arrangements used for the cloister vaults.
Parker, Brent C.; Neck, Daniel W.; Henkelmann, Greg; Rosen, Isaac I.
2010-01-01
The purpose of this study was to quantify the performance and assess the utility of two different types of scanners for radiochromic EBT film dosimetry: a commercial flatbed document scanner and a widely used radiographic film scanner. We evaluated the Epson Perfection V700 Photo flatbed scanner and the Vidar VXR Dosimetry Pro Advantage scanner as measurement devices for radiochromic EBT film. Measurements were made of scan orientation effects, response uniformity, and scanner noise. Scanners were tested using films irradiated with eight separate 3×3 cm2 fields to doses ranging from 0.115–5.119 Gy. ImageJ and RIT software was used for analyzing the Epson and Vidar scans, respectively. For repeated scans of a single film, the measurements in each dose region were reproducible to within ±0.3% standard deviation (SD) with both scanners. Film‐to‐film variations for corresponding doses were measured to be within ±0.4% SD for both Epson scanner and Vidar scanners. Overall, the Epson scanner showed a 10% smaller range of pixel value compared to the Vidar scanner. Scanner noise was small: ±0.3% SD for the Epson and ±0.2% for the Vidar. Overall measurement uniformity for blank film in both systems was better than ±0.2%, provided that the leading and trailing 2 cm film edges were neglected in the Vidar system. In this region artifacts are attributed to the film rollers. Neither system demonstrated a clear measurement advantage. The Epson scanner is a relatively inexpensive method for analyzing radiochromic film, but there is a lack of commercially available software. For a clinic already using a Vidar scanner, applying it to radiochromic film is attractive because commercial software is available. However, care must be taken to avoid using the leading and trailing film edges. PACS number: 87.55.Qr
Zbijewski, W; De Jean, P; Prakash, P; Ding, Y; Stayman, J W; Packard, N; Senn, R; Yang, D; Yorkston, J; Machado, A; Carrino, J A; Siewerdsen, J H
2011-08-01
This paper reports on the design and initial imaging performance of a dedicated cone-beam CT (CBCT) system for musculoskeletal (MSK) extremities. The system complements conventional CT and MR and offers a variety of potential clinical and logistical advantages that are likely to be of benefit to diagnosis, treatment planning, and assessment of therapy response in MSK radiology, orthopaedic surgery, and rheumatology. The scanner design incorporated a host of clinical requirements (e.g., ability to scan the weight-bearing knee in a natural stance) and was guided by theoretical and experimental analysis of image quality and dose. Such criteria identified the following basic scanner components and system configuration: a flat-panel detector (FPD, Varian 3030+, 0.194 mm pixels); and a low-power, fixed anode x-ray source with 0.5 mm focal spot (SourceRay XRS-125-7K-P, 0.875 kW) mounted on a retractable C-arm allowing for two scanning orientations with the capability for side entry, viz. a standing configuration for imaging of weight-bearing lower extremities and a sitting configuration for imaging of tensioned upper extremity and unloaded lower extremity. Theoretical modeling employed cascaded systems analysis of modulation transfer function (MTF) and detective quantum efficiency (DQE) computed as a function of system geometry, kVp and filtration, dose, source power, etc. Physical experimentation utilized an imaging bench simulating the scanner geometry for verification of theoretical results and investigation of other factors, such as antiscatter grid selection and 3D image quality in phantom and cadaver, including qualitative comparison to conventional CT. Theoretical modeling and benchtop experimentation confirmed the basic suitability of the FPD and x-ray source mentioned above. Clinical requirements combined with analysis of MTF and DQE yielded the following system geometry: a -55 cm source-to-detector distance; 1.3 magnification; a 20 cm diameter bore (20 x 20 x 20 cm3 field of view); total acquisition arc of -240 degrees. The system MTF declines to 50% at -1.3 mm(-1) and to 10% at -2.7 mm(-1), consistent with sub-millimeter spatial resolution. Analysis of DQE suggested a nominal technique of 90 kVp (+0.3 mm Cu added filtration) to provide high imaging performance from -500 projections at less than -0.5 kW power, implying -6.4 mGy (0.064 mSv) for low-dose protocols and -15 mGy (0.15 mSv) for high-quality protocols. The experimental studies show improved image uniformity and contrast-to-noise ratio (without increase in dose) through incorporation of a custom 10:1 GR antiscatter grid. Cadaver images demonstrate exquisite bone detail, visualization of articular morphology, and soft-tissue visibility comparable to diagnostic CT (10-20 HU contrast resolution). The results indicate that the proposed system will deliver volumetric images of the extremities with soft-tissue contrast resolution comparable to diagnostic CT and improved spatial resolution at potentially reduced dose. Cascaded systems analysis provided a useful basis for system design and optimization without costly repeated experimentation. A combined process of design specification, image quality analysis, clinical feedback, and revision yielded a prototype that is now awaiting clinical pilot studies. Potential advantages of the proposed system include reduced space and cost, imaging of load-bearing extremities, and combined volumetric imaging with real-time fluoroscopy and digital radiography.
Zbijewski, W.; De Jean, P.; Prakash, P.; Ding, Y.; Stayman, J. W.; Packard, N.; Senn, R.; Yang, D.; Yorkston, J.; Machado, A.; Carrino, J. A.; Siewerdsen, J. H.
2011-01-01
Purpose: This paper reports on the design and initial imaging performance of a dedicated cone-beam CT (CBCT) system for musculoskeletal (MSK) extremities. The system complements conventional CT and MR and offers a variety of potential clinical and logistical advantages that are likely to be of benefit to diagnosis, treatment planning, and assessment of therapy response in MSK radiology, orthopaedic surgery, and rheumatology. Methods: The scanner design incorporated a host of clinical requirements (e.g., ability to scan the weight-bearing knee in a natural stance) and was guided by theoretical and experimental analysis of image quality and dose. Such criteria identified the following basic scanner components and system configuration: a flat-panel detector (FPD, Varian 3030+, 0.194 mm pixels); and a low-power, fixed anode x-ray source with 0.5 mm focal spot (SourceRay XRS-125-7K-P, 0.875 kW) mounted on a retractable C-arm allowing for two scanning orientations with the capability for side entry, viz. a standing configuration for imaging of weight-bearing lower extremities and a sitting configuration for imaging of tensioned upper extremity and unloaded lower extremity. Theoretical modeling employed cascaded systems analysis of modulation transfer function (MTF) and detective quantum efficiency (DQE) computed as a function of system geometry, kVp and filtration, dose, source power, etc. Physical experimentation utilized an imaging bench simulating the scanner geometry for verification of theoretical results and investigation of other factors, such as antiscatter grid selection and 3D image quality in phantom and cadaver, including qualitative comparison to conventional CT. Results: Theoretical modeling and benchtop experimentation confirmed the basic suitability of the FPD and x-ray source mentioned above. Clinical requirements combined with analysis of MTF and DQE yielded the following system geometry: a ∼55 cm source-to-detector distance; 1.3 magnification; a 20 cm diameter bore (20 × 20 × 20 cm3 field of view); total acquisition arc of ∼240°. The system MTF declines to 50% at ∼1.3 mm−1 and to 10% at ∼2.7 mm−1, consistent with sub-millimeter spatial resolution. Analysis of DQE suggested a nominal technique of 90 kVp (+0.3 mm Cu added filtration) to provide high imaging performance from ∼500 projections at less than ∼0.5 kW power, implying ∼6.4 mGy (0.064 mSv) for low-dose protocols and ∼15 mGy (0.15 mSv) for high-quality protocols. The experimental studies show improved image uniformity and contrast-to-noise ratio (without increase in dose) through incorporation of a custom 10:1 GR antiscatter grid. Cadaver images demonstrate exquisite bone detail, visualization of articular morphology, and soft-tissue visibility comparable to diagnostic CT (10–20 HU contrast resolution). Conclusions: The results indicate that the proposed system will deliver volumetric images of the extremities with soft-tissue contrast resolution comparable to diagnostic CT and improved spatial resolution at potentially reduced dose. Cascaded systems analysis provided a useful basis for system design and optimization without costly repeated experimentation. A combined process of design specification, image quality analysis, clinical feedback, and revision yielded a prototype that is now awaiting clinical pilot studies. Potential advantages of the proposed system include reduced space and cost, imaging of load-bearing extremities, and combined volumetric imaging with real-time fluoroscopy and digital radiography. PMID:21928644
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zbijewski, W.; De Jean, P.; Prakash, P.
2011-08-15
Purpose: This paper reports on the design and initial imaging performance of a dedicated cone-beam CT (CBCT) system for musculoskeletal (MSK) extremities. The system complements conventional CT and MR and offers a variety of potential clinical and logistical advantages that are likely to be of benefit to diagnosis, treatment planning, and assessment of therapy response in MSK radiology, orthopaedic surgery, and rheumatology. Methods: The scanner design incorporated a host of clinical requirements (e.g., ability to scan the weight-bearing knee in a natural stance) and was guided by theoretical and experimental analysis of image quality and dose. Such criteria identified themore » following basic scanner components and system configuration: a flat-panel detector (FPD, Varian 3030+, 0.194 mm pixels); and a low-power, fixed anode x-ray source with 0.5 mm focal spot (SourceRay XRS-125-7K-P, 0.875 kW) mounted on a retractable C-arm allowing for two scanning orientations with the capability for side entry, viz. a standing configuration for imaging of weight-bearing lower extremities and a sitting configuration for imaging of tensioned upper extremity and unloaded lower extremity. Theoretical modeling employed cascaded systems analysis of modulation transfer function (MTF) and detective quantum efficiency (DQE) computed as a function of system geometry, kVp and filtration, dose, source power, etc. Physical experimentation utilized an imaging bench simulating the scanner geometry for verification of theoretical results and investigation of other factors, such as antiscatter grid selection and 3D image quality in phantom and cadaver, including qualitative comparison to conventional CT. Results: Theoretical modeling and benchtop experimentation confirmed the basic suitability of the FPD and x-ray source mentioned above. Clinical requirements combined with analysis of MTF and DQE yielded the following system geometry: a {approx}55 cm source-to-detector distance; 1.3 magnification; a 20 cm diameter bore (20 x 20 x 20 cm{sup 3} field of view); total acquisition arc of {approx}240 deg. The system MTF declines to 50% at {approx}1.3 mm{sup -1} and to 10% at {approx}2.7 mm{sup -1}, consistent with sub-millimeter spatial resolution. Analysis of DQE suggested a nominal technique of 90 kVp (+0.3 mm Cu added filtration) to provide high imaging performance from {approx}500 projections at less than {approx}0.5 kW power, implying {approx}6.4 mGy (0.064 mSv) for low-dose protocols and {approx}15 mGy (0.15 mSv) for high-quality protocols. The experimental studies show improved image uniformity and contrast-to-noise ratio (without increase in dose) through incorporation of a custom 10:1 GR antiscatter grid. Cadaver images demonstrate exquisite bone detail, visualization of articular morphology, and soft-tissue visibility comparable to diagnostic CT (10-20 HU contrast resolution). Conclusions: The results indicate that the proposed system will deliver volumetric images of the extremities with soft-tissue contrast resolution comparable to diagnostic CT and improved spatial resolution at potentially reduced dose. Cascaded systems analysis provided a useful basis for system design and optimization without costly repeated experimentation. A combined process of design specification, image quality analysis, clinical feedback, and revision yielded a prototype that is now awaiting clinical pilot studies. Potential advantages of the proposed system include reduced space and cost, imaging of load-bearing extremities, and combined volumetric imaging with real-time fluoroscopy and digital radiography.« less
ERIC Educational Resources Information Center
Lafayette, R. C.
1991-01-01
A discussion of the Total Physical Response method of second language instruction places the concept within the context of other unconventional language learning methods, reviews the rationale behind the approach, and outlines the classroom procedures used. A sampling of useful commands for classroom use is included. (19 references) (MSE)
An unconventional approach to ecosystem unit classification in western North Carolina, USA
W. Henry McNab; Sara A. Browning; Steven A. Simon; Penelope E. Fouts
1999-01-01
The authors used an unconventional combination of data transformation and multivariate analyses to reduce subjectivity in identification of ecosystem units in a mountainous region of western North Carolina, USA. Vegetative cover and environmental variables were measured on 79 stratified, randomly located, 0.1 ha sample plots in a 4000 ha watershed. Binary...
Warwick, Peter D.
2011-01-01
The Energy Minerals Division (EMD) of the American Association of Petroleum Geologists (AAPG) is a membership-based, technical interest group having the primary goal of advancing the science of geology, especially as it relates to exploration, discovery, and production of unconventional energy resources. Current research on unconventional energy resources is rapidly changing and exploration and development efforts for these resources are constantly expanding. Nine summaries derived from 2011 committee reports presented at the EMD Annual Meeting in Houston, Texas in April, 2011, are contained in this review. The complete set of committee reports is available to AAPG members at http://emd.aapg.org/members_only/ annual2011/index.cfm. This report updates the 2006 and 2009 EMD unconventional energy review published in this journal (American Association of Petroleum Geologists, Energy Minerals Division 2007, 2009).
From Cytosol to the Apoplast: The Hygromycin Phosphotransferase (HYG(R)) Model in Arabidopsis.
Zhang, Haiyan; Li, Jinjin
2016-01-01
The process by which proteins are secreted via endoplasmic reticulum (ER)/Golgi-independent mechanism is conveniently called unconventional protein secretion. Recent studies have revealed that unconventional protein secretion operates in plants, but little is known about its underlying mechanism and function. This chapter provides methods we have used to analyze unconventional character of hygromycin phosphotransferase (HYG(R)) secretion in plant cells. Following isolation of protoplasts from HYG (R) -GFP-transgenic plants and incubation with brefeldin A (BFA), an inhibitor of conventional secretory pathway, we easily obtain protein extracts from protoplasts and culture medium separately. These proteins are separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), followed by Western blot analysis with anti-GFP antibodies.
Jeong, Jaeyoung; Kim, Juho; Song, Kwangsun; Autumn, Kellar; Lee, Jongho
2014-01-01
Developing electronics in unconventional forms provides opportunities to expand the use of electronics in diverse applications including bio-integrated or implanted electronics. One of the key challenges lies in integrating semiconductor microdevices onto unconventional substrates without glue, high pressure or temperature that may cause damage to microdevices, substrates or interfaces. This paper describes a solution based on natural gecko setal arrays that switch adhesion mechanically on and off, enabling pick and place manipulation of thin microscale semiconductor materials onto diverse surfaces including plants and insects whose surfaces are usually rough and irregular. A demonstration of functional ‘geckoprinted’ microelectronic devices provides a proof of concept of our results in practical applications. PMID:25056216
Unconventional aspects of electronic transport in delafossite oxides
NASA Astrophysics Data System (ADS)
Daou, Ramzy; Frésard, Raymond; Eyert, Volker; Hébert, Sylvie; Maignan, Antoine
2017-12-01
The electronic transport properties of the delafossite oxides ? are usually understood in terms of two well-separated entities, namely the triangular ? and (? layers. Here, we review several cases among this extensive family of materials where the transport depends on the interlayer coupling and displays unconventional properties. We review the doped thermoelectrics based on ? and ?, which show a high-temperature recovery of Fermi-liquid transport exponents, as well as the highly anisotropic metals ?, ?, and ?, where the sheer simplicity of the Fermi surface leads to unconventional transport. We present some of the theoretical tools that have been used to investigate these transport properties and review what can and cannot be learned from the extensive set of electronic structure calculations that have been performed.
Towards simultaneous single emission microscopy and magnetic resonance imaging
NASA Astrophysics Data System (ADS)
Cai, Liang
In recent years, the combined nuclear imaging and magnetic resonance imaging (MRI) has drawn extensive research effort. They can provide simultaneously acquired anatomical and functional information inside the human/small animal body in vivo. In this dissertation, the development of an ultrahigh resolution MR-compatible SPECT (Single Photon Emission Computed Tomography) system that can be operated inside a pre-existing clinical MR scanner for simultaneous dual-modality imaging of small animals will be discussed. This system is constructed with 40 small pixel CdTe detector modules assembled in a fully stationary ring SPECT geometry. Series of experiments have demonstrated that this system is capable of providing an imaging resolution of <500?m, when operated inside MR scanners. The ultrahigh resolution MR-compatible SPECT system is built around a small pixel CdTe detector module that we recently developed. Each module consists of CdTe detectors having an overall size of 2.2 cm x 1.1 cm, divided into 64 x 32 pixels of 350 mum in size. A novel hybrid pixel-waveform (HPWF) readout system is also designed to alleviate several challenges for using small-pixel CdTe detectors in ultrahigh-resolution SPECT imaging applications. The HPWF system utilizes a modified version of a 2048-channel 2-D CMOS ASIC to readout the anode pixel, and a digitizing circuitry to sample the signal waveform induced on the cathode. The cathode waveform acquired with the HPWF circuitry offers excellent spatial resolution, energy resolution and depth of interaction (DOI) information, even with the presence of excessive charge-sharing/charge-loss between the small anode pixels. The HPWF CdTe detector is designed and constructed with a minimum amount of ferromagnetic materials, to ensure the MR-compatibility. To achieve sub-500?m imaging resolution, two special designed SPECT apertures have been constructed with different pinhole sizes of 300?m and 500?m respectively. It has 40 pinhole inserts that are made of cast platinum (90%)-iridium (10%) alloy, which provides the maximum stopping power and are compatible with MR scanners. The SPECT system is installed on a non-metal gantry constructed with 3-D printing using nylon powder material. This compact system can work as a "low-cost" desktop ultrahigh resolution SPECT system. It can also be directly operated inside an MR scanner. Accurate system geometrical calibration and corresponding image reconstruction methods for the MRC-SPECT system is developed. In order to account for the magnetic field induced distortion in the SPECT image, a comprehensive charge collection model inside strong magnetic field is adopted to produce high resolution SPECT image inside MR scanner.
Primary Beam Air Kerma Dependence on Distance from Cargo and People Scanners
DOE Office of Scientific and Technical Information (OSTI.GOV)
Strom, Daniel J.; Cerra, Frank
The distance dependence of air kerma or dose rate of the primary radiation beam is not obvious for security scanners of cargo and people in which there is relative motion between a collimated source and the person or object being imaged. To study this problem, one fixed line source and three moving-source scan-geometry cases are considered, each characterized by radiation emanating perpendicular to an axis. The cases are 1) a stationary line source of radioactive material, e.g., contaminated solution in a pipe; 2) a moving, uncollimated point source of radiation that is shuttered or off when it is stationary; 3)more » a moving, collimated point source of radiation that is shuttered or off when it is stationary; and 4) a translating, narrow “pencil” beam emanating in a flying-spot, raster pattern. Each case is considered for short and long distances compared to the line source length or path traversed by a moving source. The short distance model pertains mostly to dose to objects being scanned and personnel associated with the screening operation. The long distance model pertains mostly to potential dose to bystanders. For radionuclide sources, the number of nuclear transitions that occur a) per unit length of a line source, or b) during the traversal of a point source, is a unifying concept. The “universal source strength” of air kerma rate at a meter from the source can be used to describe x-ray machine or radionuclide sources. For many cargo and people scanners with highly collimated fan or pencil beams, dose varies as the inverse of the distance from the source in the near field and with the inverse square of the distance beyond a critical radius. Ignoring the inverse square dependence and using inverse distance dependence is conservative in the sense of tending to overestimate dose.« less
NASA Astrophysics Data System (ADS)
Stratis, A.; Zhang, G.; Jacobs, R.; Bogaerts, R.; Bosmans, H.
2016-12-01
In order to carry out Monte Carlo (MC) dosimetry studies, voxel phantoms, modeling human anatomy, and organ-based segmentation of CT image data sets are applied to simulation frameworks. The resulting voxel phantoms preserve patient CT acquisition geometry; in the case of head voxel models built upon head CT images, the head support with which CT scanners are equipped introduces an inclination to the head, and hence to the head voxel model. In dental cone beam CT (CBCT) imaging, patients are always positioned in such a way that the Frankfort line is horizontal, implying that there is no head inclination. The orientation of the head is important, as it influences the distance of critical radiosensitive organs like the thyroid and the esophagus from the x-ray tube. This work aims to propose a procedure to adjust head voxel phantom orientation, and to investigate the impact of head inclination on organ doses in dental CBCT MC dosimetry studies. The female adult ICRP, and three in-house-built paediatric voxel phantoms were in this study. An EGSnrc MC framework was employed to simulate two commonly used protocols; a Morita Accuitomo 170 dental CBCT scanner (FOVs: 60 × 60 mm2 and 80 × 80 mm2, standard resolution), and a 3D Teeth protocol (FOV: 100 × 90 mm2) in a Planmeca Promax 3D MAX scanner. Result analysis revealed large absorbed organ dose differences in radiosensitive organs between the original and the geometrically corrected voxel models of this study, ranging from -45.6% to 39.3%. Therefore, accurate dental CBCT MC dose calculations require geometrical adjustments to be applied to head voxel models.
Primary Beam Air Kerma Dependence on Distance from Cargo and People Scanners.
Strom, Daniel J; Cerra, Frank
2016-06-01
The distance dependence of air kerma or dose rate of the primary radiation beam is not obvious for security scanners of cargo and people in which there is relative motion between a collimated source and the person or object being imaged. To study this problem, one fixed line source and three moving-source scan-geometry cases are considered, each characterized by radiation emanating perpendicular to an axis. The cases are 1) a stationary line source of radioactive material, e.g., contaminated solution in a pipe; 2) a moving, uncollimated point source of radiation that is shuttered or off when it is stationary; 3) a moving, collimated point source of radiation that is shuttered or off when it is stationary; and 4) a translating, narrow "pencil" beam emanating in a flying-spot, raster pattern. Each case is considered for short and long distances compared to the line source length or path traversed by a moving source. The short distance model pertains mostly to dose to objects being scanned and personnel associated with the screening operation. The long distance model pertains mostly to potential dose to bystanders. For radionuclide sources, the number of nuclear transitions that occur a) per unit length of a line source or b) during the traversal of a point source is a unifying concept. The "universal source strength" of air kerma rate at 1 m from the source can be used to describe x-ray machine or radionuclide sources. For many cargo and people scanners with highly collimated fan or pencil beams, dose varies as the inverse of the distance from the source in the near field and with the inverse square of the distance beyond a critical radius. Ignoring the inverse square dependence and using inverse distance dependence is conservative in the sense of tending to overestimate dose.
Telescope with a wide field of view internal optical scanner
NASA Technical Reports Server (NTRS)
Zheng, Yunhui (Inventor); Degnan, III, John James (Inventor)
2012-01-01
A telescope with internal scanner utilizing either a single optical wedge scanner or a dual optical wedge scanner and a controller arranged to control a synchronous rotation of the first and/or second optical wedges, the wedges constructed and arranged to scan light redirected by topological surfaces and/or volumetric scatterers. The telescope with internal scanner further incorporates a first converging optical element that receives the redirected light and transmits the redirected light to the scanner, and a second converging optical element within the light path between the first optical element and the scanner arranged to reduce an area of impact on the scanner of the beam collected by the first optical element.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Liao, S; Wang, Y; Weng, H
Purpose To evaluate image quality and radiation dose of routine abdomen computed tomography exam with the automatic current modulation technique (ATCM) performed in two different brand 64-slice CT scanners in our site. Materials and Methods A retrospective review of routine abdomen CT exam performed with two scanners; scanner A and scanner B in our site. To calculate standard deviation of the portal hepatic level with a region of interest of 12.5 mm x 12.5mm represented to the image noise. The radiation dose was obtained from CT DICOM image information. Using Computed tomography dose index volume (CTDIv) to represented CT radiationmore » dose. The patient data in this study were with normal weight (about 65–75 Kg). Results The standard deviation of Scanner A was smaller than scanner B, the scanner A might with better image quality than scanner B. On the other hand, the radiation dose of scanner A was higher than scanner B(about higher 50–60%) with ATCM. Both of them, the radiation dose was under diagnostic reference level. Conclusion The ATCM systems in modern CT scanners can contribute a significant reduction in radiation dose to the patient. But the reduction by ATCM systems from different CT scanner manufacturers has slightly variation. Whatever CT scanner we use, it is necessary to find the acceptable threshold of image quality with the minimum possible radiation exposure to the patient in agreement with the ALARA principle.« less
Liquid crystals in micron-scale droplets, shells and fibers
NASA Astrophysics Data System (ADS)
Urbanski, Martin; Reyes, Catherine G.; Noh, JungHyun; Sharma, Anshul; Geng, Yong; Subba Rao Jampani, Venkata; Lagerwall, Jan P. F.
2017-04-01
The extraordinary responsiveness and large diversity of self-assembled structures of liquid crystals are well documented and they have been extensively used in devices like displays. For long, this application route strongly influenced academic research, which frequently focused on the performance of liquid crystals in display-like geometries, typically between flat, rigid substrates of glass or similar solids. Today a new trend is clearly visible, where liquid crystals confined within curved, often soft and flexible, interfaces are in focus. Innovation in microfluidic technology has opened for high-throughput production of liquid crystal droplets or shells with exquisite monodispersity, and modern characterization methods allow detailed analysis of complex director arrangements. The introduction of electrospinning in liquid crystal research has enabled encapsulation in optically transparent polymeric cylinders with very small radius, allowing studies of confinement effects that were not easily accessible before. It also opened the prospect of functionalizing textile fibers with liquid crystals in the core, triggering activities that target wearable devices with true textile form factor for seamless integration in clothing. Together, these developments have brought issues center stage that might previously have been considered esoteric, like the interaction of topological defects on spherical surfaces, saddle-splay curvature-induced spontaneous chiral symmetry breaking, or the non-trivial shape changes of curved liquid crystal elastomers with non-uniform director fields that undergo a phase transition to an isotropic state. The new research thrusts are motivated equally by the intriguing soft matter physics showcased by liquid crystals in these unconventional geometries, and by the many novel application opportunities that arise when we can reproducibly manufacture these systems on a commercial scale. This review attempts to summarize the current understanding of liquid crystals in spherical and cylindrical geometry, the state of the art of producing such samples, as well as the perspectives for innovative applications that have been put forward.
Accuracy of complete-arch model using an intraoral video scanner: An in vitro study.
Jeong, Il-Do; Lee, Jae-Jun; Jeon, Jin-Hun; Kim, Ji-Hwan; Kim, Hae-Young; Kim, Woong-Chul
2016-06-01
Information on the accuracy of intraoral video scanners for long-span areas is limited. The purpose of this in vitro study was to evaluate and compare the trueness and precision of an intraoral video scanner, an intraoral still image scanner, and a blue-light scanner for the production of digital impressions. Reference scan data were obtained by scanning a complete-arch model. An identical model was scanned 8 times using an intraoral video scanner (CEREC Omnicam; Sirona) and an intraoral still image scanner (CEREC Bluecam; Sirona), and stone casts made from conventional impressions of the same model were scanned 8 times with a blue-light scanner as a control (Identica Blue; Medit). Accuracy consists of trueness (the extent to which the scan data differ from the reference scan) and precision (the similarity of the data from multiple scans). To evaluate precision, 8 scans were superimposed using 3-dimensional analysis software; the reference scan data were then superimposed to determine the trueness. Differences were analyzed using 1-way ANOVA and post hoc Tukey HSD tests (α=.05). Trueness in the video scanner group was not significantly different from that in the control group. However, the video scanner group showed significantly lower values than those of the still image scanner group for all variables (P<.05), except in tolerance range. The root mean square, standard deviations, and mean negative precision values for the video scanner group were significantly higher than those for the other groups (P<.05). Digital impressions obtained by the intraoral video scanner showed better accuracy for long-span areas than those captured by the still image scanner. However, the video scanner was less accurate than the laboratory scanner. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.
Seo, Yeong-Hyeon; Hwang, Kyungmin; Jeong, Ki-Hun
2018-02-19
We report a 1.65 mm diameter forward-viewing confocal endomicroscopic catheter using a flip-chip bonded electrothermal MEMS fiber scanner. Lissajous scanning was implemented by the electrothermal MEMS fiber scanner. The Lissajous scanned MEMS fiber scanner was precisely fabricated to facilitate flip-chip connection, and bonded with a printed circuit board. The scanner was successfully combined with a fiber-based confocal imaging system. A two-dimensional reflectance image of the metal pattern 'OPTICS' was successfully obtained with the scanner. The flip-chip bonded scanner minimizes electrical packaging dimensions. The inner diameter of the flip-chip bonded MEMS fiber scanner is 1.3 mm. The flip-chip bonded MEMS fiber scanner is fully packaged with a 1.65 mm diameter housing tube, 1 mm diameter GRIN lens, and a single mode optical fiber. The packaged confocal endomicroscopic catheter can provide a new breakthrough for diverse in-vivo endomicroscopic applications.
Optimizing Water Management for Collocated Conventional and Unconventional Reservoirs
NASA Astrophysics Data System (ADS)
Reedy, R. C.; Scanlon, B. R.; Walsh, M.
2016-12-01
With the U.S. producing much more water than oil from oil and gas reservoirs, managing produced water is becoming a critical issue. Here we quantify water production from collocated conventional and unconventional reservoirs using well by well analysis and evaluate various water management strategies using the U.S. Permian Basin as a case study. Water production during the past 15 years in the Permian Basin totaled 55×109 barrels (bbl), 95% from wells in conventional reservoirs resulting in an average water to oil ratio of 12 compared to ratios of 2-3 in wells in unconventional reservoirs. Some of this water ( 25%) is returned to the reservoir for secondary oil recovery (water flooding) while the remaining water is injected into an average of 18,000 salt water disposal wells. Total water production over the past 15 yr (2000 - 2015) exceeds water used for hydraulic fracturing by almost 40 times. Analyzing water injection into salt water disposal wells relative to water requirements for hydraulic fracturing at a 5 square mile grid scale based on 2014 data indicates that water disposal exceeds water requirements for hydraulic fracturing throughout most of the play. Reusing/recycling of produced water for hydraulic fracturing would reduce sourcing and disposal issues related to hydraulic fracturing. Because shales (unconventional reservoirs) provide the source rocks for many conventional reservoirs, coordinating water management from both conventional and unconventional reservoirs can help resolve issues related to sourcing of water for hydraulic fracturing and disposing of produced water. Reusing/recycling produced water can also help reduce water scarcity concerns in some regions.
Kelly, Owen J; Gilman, Jennifer C
2017-01-01
Body composition changes occur with aging; bone and muscle mass decrease while fat mass increases. The collective term for these changes is osteosarcopenic obesity. It is known that conventional resistance exercise programs build/maintain lean mass and reduce fat mass. However, unconventional (to Western society/medicine) forms of exercise may be viable for the treatment/prevention of osteosarcopenic obesity. The purpose of this review is to assess relatively unconventional exercises for their efficacy in maintaining/improving bone and muscle mass and reducing fat mass. A literature search for unconventional exercise showed Tai Chi, yoga, Pilates, whole body vibration, electrical stimulation of muscle, and the Alexander Technique were considered alternative/ unconventional. A PubMed and Medline search for human data using combinations and synonyms of osteoporosis, sarcopenia and obesity, and each exercise was then conducted. Tai Chi, yoga, and Pilates, in addition to whole body vibration, electrical stimulation of muscle, and the Alexander Technique are all considered low impact. Tai Chi, yoga, and Pilates not only physically support the body, but also increase balance and quality of life. The devices showed promise in reducing or preventing muscle atrophy in older people that are unable to perform conventional exercises. Any exercise, conventional or otherwise, especially in sedentary older people, at risk of, or diagnosed with osteosarcopenic obesity may be better than none. Exercise prescriptions should suit the patient and the desired outcomes; the patient should not be forced to fit an exercise prescription, so all potential forms of exercise should be considered. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Novel gradient-diameter magnetic nanowire arrays with unconventional magnetic anisotropy behaviors.
Wang, Jing; Zuo, Zhili; Huang, Liang; Warsi, Muhammad Asif; Xiao, John Q; Hu, Jun
2018-06-21
Fe-Co-Ni gradient-diameter magnetic nanowire arrays were fabricated via direct-current electrodeposition into a tapered anodic aluminium oxide template. In contrast to the magnetic behaviors of uniform-diameter nanowire arrays, these arrays exhibited tailorable magnetic anisotropy that can be used to switch magnetic nanowires easily and unconventional temperature-dependent coercivity with much better thermal stability.
Unconventional Dentistry in India – An Insight into the Traditional Methods
Boloor, Vinita Ashutosh; Hosadurga, Rajesh; Rao, Anupama; Jenifer, Haziel; Pratap, Sruthy
2014-01-01
Unconventional medicine (UM) has been known and practised since the recorded history of civilization. Some unconventional practices may be viewed as “the continuity of traditions, religious beliefs, and even quackery that non-specialists practice.” These practices have been associated with religious beliefs and the spiritual domain as well as with the physical domain. In ancient Old World civilizations, UM was performed by skilled experts or wise men; in today's Western civilization, practitioners may or may not be licensed, and some are charlatans. Dentistry, like medicine, is a traditional, science-based, highly regulated healthcare profession that serves increasingly sophisticated and demanding clients. Today, traditional dental practice is dealing with an array of challenges to the established professional system; these challenges are generally termed “alternative” (or complementary, unconventional, or integrative). Genuine alternatives are comparable methods of equal value that have met scientific and regulatory criteria for safety and effectiveness. Because “alternative care” has become politicized and is often a misnomer – referring to practices that are not alternative to, complementary to, or integrating with conventional health care – the more accurate term “unconventional” is used. PMID:25161919
Nelson, Andrew W; Knight, Andrew W; Eitrheim, Eric S; Schultz, Michael K
2015-04-01
Unconventional drilling (the combination of hydraulic fracturing and horizontal drilling) to extract oil and natural gas is expanding rapidly around the world. The rate of expansion challenges scientists and regulators to assess the risks of the new technologies on drinking water resources. One concern is the potential for subsurface drinking water resource contamination by naturally occurring radioactive materials co-extracted during unconventional drilling activities. Given the rate of expansion, opportunities to test drinking water resources in the pre- and post-fracturing setting are rare. This pilot study investigated the levels of natural uranium, lead-210, and polonium-210 in private drinking wells within 2000 m of a large-volume hydraulic fracturing operation--before and approximately one-year following the fracturing activities. Observed radionuclide concentrations in well waters tested did not exceed maximum contaminant levels recommended by state and federal agencies. No statistically-significant differences in radionuclide concentrations were observed in well-water samples collected before and after the hydraulic fracturing activities. Expanded monitoring of private drinking wells before and after hydraulic fracturing activities is needed to develop understanding of the potential for drinking water resource contamination from unconventional drilling and gas extraction activities. Copyright © 2015 Elsevier Ltd. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Walker, B; Radtke, J; Chen, G
Purpose: To develop and build a practical implementation of an x-ray line source for the rapidly increasing number of multi-source imaging applications in CT. Methods: An innovative x-ray tube was designed using CST Particle Studio, ANSYS, and SolidWorks. A slowly varying magnetic field is synchronized with microsecond gating of multiple thermionic electron sources. Electrostatic simulations were run to optimize the geometry of the optics and prevent electrode arcing. Magnetostatic simulations were used for beam deflection studies and solenoid design. Particle beam trajectories were explored with an emphasis on focusing, acceleration, deflection, and space charge effects. Thermal constraints were analyzed formore » both transient and steady-state regimes. Electromagnetic simulations informed the design of a prototype unit under construction. Results: Particle tracking simulations for a benchtop system demonstrate that three 80 keV electron beams are able to be finely controlled and laterally swept a combined distance of 15 cm over a stationary target with an oscillating magnetic field in the hundreds of gauss. The beams are pulsed according to scanning sequences developed for implementation in a mock stationary CT scanner capable of a 30 ms temporal resolution. Beam spot diameters are approximately 1 mm for 30 mA beams and the stationary target stays well within thermal limits. The relevant hardware and control circuits were developed for incorporation into a physical prototype. Conclusion: A new multi-source x-ray tube was designed in a modular form factor to push the barriers of high-speed CT and spur growth in emerging imaging applications. This technology can be used as the basis for a stationary high-speed CT scanner, a system for generating a virtual fan-beam for dose reduction, or for reducing scatter radiation in cone-beam CT utilizing a tetrahedron beam CT geometry. A 2.4 kW benchtop system is currently being built to show proof of concept for the tube. Support for this research was provided by the University of Wisconsin Madison, Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation.« less
2009-01-01
Background Structural Magnetic Resonance Imaging (sMRI) of the brain is employed in the assessment of a wide range of neuropsychiatric disorders. In order to improve statistical power in such studies it is desirable to pool scanning resources from multiple centres. The CaliBrain project was designed to provide for an assessment of scanner differences at three centres in Scotland, and to assess the practicality of pooling scans from multiple-centres. Methods We scanned healthy subjects twice on each of the 3 scanners in the CaliBrain project with T1-weighted sequences. The tissue classifier supplied within the Statistical Parametric Mapping (SPM5) application was used to map the grey and white tissue for each scan. We were thus able to assess within scanner variability and between scanner differences. We have sought to correct for between scanner differences by adjusting the probability mappings of tissue occupancy (tissue priors) used in SPM5 for tissue classification. The adjustment procedure resulted in separate sets of tissue priors being developed for each scanner and we refer to these as scanner specific priors. Results Voxel Based Morphometry (VBM) analyses and metric tests indicated that the use of scanner specific priors reduced tissue classification differences between scanners. However, the metric results also demonstrated that the between scanner differences were not reduced to the level of within scanner variability, the ideal for scanner harmonisation. Conclusion Our results indicate the development of scanner specific priors for SPM can assist in pooling of scan resources from different research centres. This can facilitate improvements in the statistical power of quantitative brain imaging studies. PMID:19445668
Computational Aerodynamic Analysis of Three-Dimensional Ice Shapes on a NACA 23012 Airfoil
NASA Technical Reports Server (NTRS)
Jun, GaRam; Oliden, Daniel; Potapczuk, Mark G.; Tsao, Jen-Ching
2014-01-01
The present study identifies a process for performing computational fluid dynamic calculations of the flow over full three-dimensional (3D) representations of complex ice shapes deposited on aircraft surfaces. Rime and glaze icing geometries formed on a NACA23012 airfoil were obtained during testing in the NASA Glenn Research Centers Icing Research Tunnel (IRT). The ice shape geometries were scanned as a cloud of data points using a 3D laser scanner. The data point clouds were meshed using Geomagic software to create highly accurate models of the ice surface. The surface data was imported into Pointwise grid generation software to create the CFD surface and volume grids. It was determined that generating grids in Pointwise for complex 3D icing geometries was possible using various techniques that depended on the ice shape. Computations of the flow fields over these ice shapes were performed using the NASA National Combustion Code (NCC). Results for a rime ice shape for angle of attack conditions ranging from 0 to 10 degrees and for freestream Mach numbers of 0.10 and 0.18 are presented. For validation of the computational results, comparisons were made to test results from rapid-prototype models of the selected ice accretion shapes, obtained from a separate study in a subsonic wind tunnel at the University of Illinois at Urbana-Champaign. The computational and experimental results were compared for values of pressure coefficient and lift. Initial results show fairly good agreement for rime ice accretion simulations across the range of conditions examined. The glaze ice results are promising but require some further examination.
Computational Aerodynamic Analysis of Three-Dimensional Ice Shapes on a NACA 23012 Airfoil
NASA Technical Reports Server (NTRS)
Jun, Garam; Oliden, Daniel; Potapczuk, Mark G.; Tsao, Jen-Ching
2014-01-01
The present study identifies a process for performing computational fluid dynamic calculations of the flow over full three-dimensional (3D) representations of complex ice shapes deposited on aircraft surfaces. Rime and glaze icing geometries formed on a NACA23012 airfoil were obtained during testing in the NASA Glenn Research Center's Icing Research Tunnel (IRT). The ice shape geometries were scanned as a cloud of data points using a 3D laser scanner. The data point clouds were meshed using Geomagic software to create highly accurate models of the ice surface. The surface data was imported into Pointwise grid generation software to create the CFD surface and volume grids. It was determined that generating grids in Pointwise for complex 3D icing geometries was possible using various techniques that depended on the ice shape. Computations of the flow fields over these ice shapes were performed using the NASA National Combustion Code (NCC). Results for a rime ice shape for angle of attack conditions ranging from 0 to 10 degrees and for freestream Mach numbers of 0.10 and 0.18 are presented. For validation of the computational results, comparisons were made to test results from rapid-prototype models of the selected ice accretion shapes, obtained from a separate study in a subsonic wind tunnel at the University of Illinois at Urbana-Champaign. The computational and experimental results were compared for values of pressure coefficient and lift. Initial results show fairly good agreement for rime ice accretion simulations across the range of conditions examined. The glaze ice results are promising but require some further examination.
Recent micro-CT scanner developments at UGCT
NASA Astrophysics Data System (ADS)
Dierick, Manuel; Van Loo, Denis; Masschaele, Bert; Van den Bulcke, Jan; Van Acker, Joris; Cnudde, Veerle; Van Hoorebeke, Luc
2014-04-01
This paper describes two X-ray micro-CT scanners which were recently developed to extend the experimental possibilities of microtomography research at the Centre for X-ray Tomography (www.ugct.ugent.be) of the Ghent University (Belgium). The first scanner, called Nanowood, is a wide-range CT scanner with two X-ray sources (160 kVmax) and two detectors, resolving features down to 0.4 μm in small samples, but allowing samples up to 35 cm to be scanned. This is a sample size range of 3 orders of magnitude, making this scanner well suited for imaging multi-scale materials such as wood, stone, etc. Besides the traditional cone-beam acquisition, Nanowood supports helical acquisition, and it can generate images with significant phase-contrast contributions. The second scanner, known as the Environmental micro-CT scanner (EMCT), is a gantry based micro-CT scanner with variable magnification for scanning objects which are not easy to rotate in a standard micro-CT scanner, for example because they are physically connected to external experimental hardware such as sensor wiring, tubing or others. This scanner resolves 5 μm features, covers a field-of-view of about 12 cm wide with an 80 cm vertical travel range. Both scanners will be extensively described and characterized, and their potential will be demonstrated with some key application results.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Turner, Adam C.; Zankl, Maria; DeMarco, John J.
2010-04-15
Purpose: Monte Carlo radiation transport techniques have made it possible to accurately estimate the radiation dose to radiosensitive organs in patient models from scans performed with modern multidetector row computed tomography (MDCT) scanners. However, there is considerable variation in organ doses across scanners, even when similar acquisition conditions are used. The purpose of this study was to investigate the feasibility of a technique to estimate organ doses that would be scanner independent. This was accomplished by assessing the ability of CTDI{sub vol} measurements to account for differences in MDCT scanners that lead to organ dose differences. Methods: Monte Carlo simulationsmore » of 64-slice MDCT scanners from each of the four major manufacturers were performed. An adult female patient model from the GSF family of voxelized phantoms was used in which all ICRP Publication 103 radiosensitive organs were identified. A 120 kVp, full-body helical scan with a pitch of 1 was simulated for each scanner using similar scan protocols across scanners. From each simulated scan, the radiation dose to each organ was obtained on a per mA s basis (mGy/mA s). In addition, CTDI{sub vol} values were obtained from each scanner for the selected scan parameters. Then, to demonstrate the feasibility of generating organ dose estimates from scanner-independent coefficients, the simulated organ dose values resulting from each scanner were normalized by the CTDI{sub vol} value for those acquisition conditions. Results: CTDI{sub vol} values across scanners showed considerable variation as the coefficient of variation (CoV) across scanners was 34.1%. The simulated patient scans also demonstrated considerable differences in organ dose values, which varied by up to a factor of approximately 2 between some of the scanners. The CoV across scanners for the simulated organ doses ranged from 26.7% (for the adrenals) to 37.7% (for the thyroid), with a mean CoV of 31.5% across all organs. However, when organ doses are normalized by CTDI{sub vol} values, the differences across scanners become very small. For the CTDI{sub vol}, normalized dose values the CoVs across scanners for different organs ranged from a minimum of 2.4% (for skin tissue) to a maximum of 8.5% (for the adrenals) with a mean of 5.2%. Conclusions: This work has revealed that there is considerable variation among modern MDCT scanners in both CTDI{sub vol} and organ dose values. Because these variations are similar, CTDI{sub vol} can be used as a normalization factor with excellent results. This demonstrates the feasibility of establishing scanner-independent organ dose estimates by using CTDI{sub vol} to account for the differences between scanners.« less
NASA Astrophysics Data System (ADS)
Kutulakos, Kyros N.; O'Toole, Matthew
2015-03-01
Conventional cameras record all light falling on their sensor regardless of the path that light followed to get there. In this paper we give an overview of a new family of computational cameras that offers many more degrees of freedom. These cameras record just a fraction of the light coming from a controllable source, based on the actual 3D light path followed. Photos and live video captured this way offer an unconventional view of everyday scenes in which the effects of scattering, refraction and other phenomena can be selectively blocked or enhanced, visual structures that are too subtle to notice with the naked eye can become apparent, and object appearance can depend on depth. We give an overview of the basic theory behind these cameras and their DMD-based implementation, and discuss three applications: (1) live indirect-only imaging of complex everyday scenes, (2) reconstructing the 3D shape of scenes whose geometry or material properties make them hard or impossible to scan with conventional methods, and (3) acquiring time-of-flight images that are free of multi-path interference.
Bose polaronic soliton-molecule and vector solitons in PT -symmetric potential
NASA Astrophysics Data System (ADS)
Boudjemâa, Abdelâali
2017-07-01
We study analytically and numerically the properties of polaronic soliton molecules and vector solitons of a trapped Bose-Einstein condensate (BEC)-impurity mixture subjected to a PT -symmetric potential in a quasi one-dimensional geometry employing our time-dependent Hartree-Fock-Bogoliubov equations. Analytical results, based on a variational approach and checked with direct numerical simulations reveal that the width, chirp, the vibration frequency and the profile of impurity solitons are enhanced by varying the strengths of real and imaginary parts of PT -symmetric potential as well as the boson-boson and boson-impurity interaction. We address the impact of the imaginary part of the potential, which represents a gain-loss mechanism, on the dynamics and on the stability of the impurity soliton-molecule. We show that for sufficiently strong complex part of the potential, the single soliton exhibits a snake instability and the molecule destroys analogous to the dissociation of a diatomic molecule. We discuss, on the other hand, the formation of several unusual families of three-component vector solitons in the BEC-impurity mixture. An unconventional dark (D)-bright (B) soliton conversion is found.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Vilmercati, Paolo; Mo, Sung -Kwan; Fedorov, Alexei
Here, we report systematic angle-resolved photoemission (ARPES) experiments using different photon polarizations and experimental geometries and find that the doping evolution of the normal state of Ba(Fe 1–xCo x) 2As 2 deviates significantly from the predictions of a rigid band model. The data reveal a nonmonotonic dependence upon doping of key quantities such as band filling, bandwidth of the electron pocket, and quasiparticle coherence. Our analysis suggests that the observed phenomenology and the inapplicability of the rigid band model in Co-doped Ba122 are due to electronic correlations, and not to the either the strength of the impurity potential, or self-energymore » effects due to impurity scattering. Our findings indicate that the effects of doping in pnictides are much more complicated than currently believed. More generally, they indicate that a deep understanding of the evolution of the electronic properties of the normal state, which requires an understanding of the doping process, remains elusive even for the 122 iron-pnictides, which are viewed as the least correlated of the high-T C unconventional superconductors.« less
Choudhary, Nitin; Li, Chao; Chung, Hee-Suk; Moore, Julian; Thomas, Jayan; Jung, Yeonwoong
2016-12-27
Two-dimensional (2D) transition-metal dichalcogenides (TMDs) have emerged as promising capacitive materials for supercapacitor devices owing to their intrinsically layered structure and large surface areas. Hierarchically integrating 2D TMDs with other functional nanomaterials has recently been pursued to improve electrochemical performances; however, it often suffers from limited cyclic stabilities and capacitance losses due to the poor structural integrity at the interfaces of randomly assembled materials. Here, we report high-performance core/shell nanowire supercapacitors based on an array of one-dimensional (1D) nanowires seamlessly integrated with conformal 2D TMD layers. The 1D and 2D supercapacitor components possess "one-body" geometry with atomically sharp and structurally robust core/shell interfaces, as they were spontaneously converted from identical metal current collectors via sequential oxidation/sulfurization. These hybrid supercapacitors outperform previously developed any stand-alone 2D TMD-based supercapacitors; particularly, exhibiting an exceptional charge-discharge retention over 30,000 cycles owing to their structural robustness, suggesting great potential for unconventional energy storage technologies.
NASA Technical Reports Server (NTRS)
Polzien, R. E.; Rodriguez, D.
1981-01-01
Aspects of incorporating a thermal energy transport system (ETS) into a field of parabolic dish collectors for industrial process heat (IPH) applications were investigated. Specific objectives are to: (1) verify the mathematical optimization of pipe diameters and insulation thicknesses calculated by a computer code; (2) verify the cost model for pipe network costs using conventional pipe network construction; (3) develop a design and the associated production costs for incorporating risers and downcomers on a low cost concentrator (LCC); (4) investigate the cost reduction of using unconventional pipe construction technology. The pipe network design and costs for a particular IPH application, specifically solar thermally enhanced oil recovery (STEOR) are analyzed. The application involves the hybrid operation of a solar powered steam generator in conjunction with a steam generator using fossil fuels to generate STEOR steam for wells. It is concluded that the STEOR application provides a baseline pipe network geometry used for optimization studies of pipe diameter and insulation thickness, and for development of comparative cost data, and operating parameters for the design of riser/downcomer modifications to the low cost concentrator.
Long-range speckle imaging theory, simulation, and brassboard results
NASA Astrophysics Data System (ADS)
Riker, Jim F.; Tyler, Glenn A.; Vaughn, Jeff L.
2017-09-01
In the SPIE 2016 Unconventional Imaging session, the authors laid out a breakthrough new theory for active array imaging that exploits the speckle return to generate a high-resolution picture of the target. Since then, we have pursued that theory even in long-range (<1000-km) engagement scenarios and shown how we can obtain that high-resolution image of the target using only a few illuminators, or by using many illuminators. There is a trade of illuminators versus receivers, but many combinations provide the same synthetic aperture resolution. We will discuss that trade, along with the corresponding radiometric and speckle-imaging Signal-to-Noise Ratios (SNR) for geometries that can fit on relatively small aircraft, such as an Unmanned Aerial Vehicle (UAV). Furthermore, we have simulated the performance of the technique, and we have created a laboratory version of the approach that is able to obtain high-resolution speckle imagery. The principal results presented in this paper are the Signal to Noise Ratios (SNR) for both the radiometric and the speckle imaging portions of the problem, and the simulated results obtained for representative arrays.
Chalcogenide glass-on-graphene photonics
NASA Astrophysics Data System (ADS)
Lin, Hongtao; Song, Yi; Huang, Yizhong; Kita, Derek; Deckoff-Jones, Skylar; Wang, Kaiqi; Li, Lan; Li, Junying; Zheng, Hanyu; Luo, Zhengqian; Wang, Haozhe; Novak, Spencer; Yadav, Anupama; Huang, Chung-Che; Shiue, Ren-Jye; Englund, Dirk; Gu, Tian; Hewak, Daniel; Richardson, Kathleen; Kong, Jing; Hu, Juejun
2017-12-01
Two-dimensional (2D) materials are of tremendous interest to integrated photonics, given their singular optical characteristics spanning light emission, modulation, saturable absorption and nonlinear optics. To harness their optical properties, these atomically thin materials are usually attached onto prefabricated devices via a transfer process. Here, we present a new route for 2D material integration with planar photonics. Central to this approach is the use of chalcogenide glass, a multifunctional material that can be directly deposited and patterned on a wide variety of 2D materials and can simultaneously function as the light-guiding medium, a gate dielectric and a passivation layer for 2D materials. Besides achieving improved fabrication yield and throughput compared with the traditional transfer process, our technique also enables unconventional multilayer device geometries optimally designed for enhancing light-matter interactions in the 2D layers. Capitalizing on this facile integration method, we demonstrate a series of high-performance glass-on-graphene devices including ultra-broadband on-chip polarizers, energy-efficient thermo-optic switches, as well as graphene-based mid-infrared waveguide-integrated photodetectors and modulators.
The influence of focal spot blooming on high-contrast spatial resolution in CT imaging.
Grimes, Joshua; Duan, Xinhui; Yu, Lifeng; Halaweish, Ahmed F; Haag, Nicole; Leng, Shuai; McCollough, Cynthia
2015-10-01
The objective of this work was to investigate focal spot blooming effects on the spatial resolution of CT images and to evaluate an x-ray tube that uses dynamic focal spot control for minimizing focal spot blooming. The influence of increasing tube current at a fixed tube potential of 80 kV on high-contrast spatial resolution of seven different CT scanner models (scanners A-G), including one scanner that uses dynamic focal spot control to reduce focal spot blooming (scanner A), was evaluated. Spatial resolution was assessed using a wire phantom for the modulation transfer function (MTF) calculation and a copper disc phantom for measuring the slice sensitivity profile (SSP). The impact of varying the tube potential was investigated on two scanner models (scanners A and B) by measuring the MTF and SSP and also by using the resolution bar pattern module of the ACR CT phantom. The phantoms were scanned at 70-150 kV on scanner A and 80-140 kV on scanner B, with tube currents from 100 mA up to the maximum tube current available on each scanner. The images were reconstructed using a slice thickness of 0.6 mm with both smooth and sharp kernels. Additionally, focal spot size at varying tube potentials and currents was directly measured using pinhole and slit camera techniques. Evaluation of the MTF and SSP data from the 7 CT scanner models evaluated demonstrated decreased focal spot blooming for newer scanners, as evidenced by decreasing deviations in MTF and SSP as tube current varied. For scanners A and B, where focal spot blooming effects as a function of tube potential were assessed, the spatial resolution variation in the axial plane was much smaller on scanner A compared to scanner B as tube potential and current changed. On scanner A, the 50% MTF never decreased by more than 2% from the 50% MTF measured at 100 mA. On scanner B, the 50% MTF decreased by as much as 19% from the 50% MTF measured at 100 mA. Assessments of the SSP, the bar patterns in the ACR phantom and the pinhole and slit camera measurements were consistent with the MTF calculations. Focal spot blooming has a noticeable effect on spatial resolution in CT imaging. The focal spot shaping technology of scanner A greatly reduced blooming effects.
Accuracy of single-abutment digital cast obtained using intraoral and cast scanners.
Lee, Jae-Jun; Jeong, Ii-Do; Park, Jin-Young; Jeon, Jin-Hun; Kim, Ji-Hwan; Kim, Woong-Chul
2017-02-01
Scanners are frequently used in the fabrication of dental prostheses. However, the accuracy of these scanners is variable, and little information is available. The purpose of this in vitro study was to compare the accuracy of cast scanners with that of intraoral scanners by using different image impression techniques. A poly(methyl methacrylate) master model was fabricated to replicate a maxillary first molar single-abutment tooth model. The master model was scanned with an accurate engineering scanner to obtain a true value (n=1) and with 2 intraoral scanners (CEREC Bluecam and CEREC Omnicam; n=6 each). The cast scanner scanned the master model and duplicated the dental stone cast from the master model (n=6). The trueness and precision of the data were measured using a 3-dimensional analysis program. The Kruskal-Wallis test was used to compare the different sets of scanning data, followed by a post hoc Mann-Whitney U test with a significance level modified by Bonferroni correction (α/6=.0083). The type 1 error level (α) was set at .05. The trueness value (root mean square: mean ±standard deviation) was 17.5 ±1.8 μm for the Bluecam, 13.8 ±1.4 μm for the Omnicam, 17.4 ±1.7 μm for cast scanner 1, and 12.3 ±0.1 μm for cast scanner 2. The differences between the Bluecam and the cast scanner 1 and between the Omnicam and the cast scanner 2 were not statistically significant (P>.0083), but a statistically significant difference was found between all the other pairs (P<.0083). The precision of the scanners was 12.7 ±2.6 μm for the Bluecam, 12.5 ±3.7 μm for the Omnicam, 9.2 ±1.2 μm for cast scanner 1, and 6.9 ±2.6 μm for cast scanner 2. The differences between Bluecam and Omnicam and between Omnicam and cast scanner 1 were not statistically significant (P>.0083), but there was a statistically significant difference between all the other pairs (P<.0083). An Omnicam in video image impression had better trueness than a cast scanner but with a similar level of precision. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.
Lárraga-Gutiérrez, José Manuel; García-Garduño, Olivia Amanda; Treviño-Palacios, Carlos; Herrera-González, José Alfredo
2018-03-01
Flatbed scanners are the most frequently used reading instrument for radiochromic film dosimetry because its low cost, high spatial resolution, among other advantages. These scanners use a fluorescent lamp and a CCD array as light source and detector, respectively. Recently, manufacturers of flatbed scanners replaced the fluorescent lamp by light emission diodes (LED) as a light source. The goal of this work is to evaluate the performance of a commercial flatbed scanner with LED based source light for radiochromic film dosimetry. Film read out consistency, response uniformity, film-scanner sensitivity, long term stability and total dose uncertainty was evaluated. In overall, the performance of the LED flatbed scanner is comparable to that of a cold cathode fluorescent lamp (CCFL). There are important spectral differences between LED and CCFL lamps that results in a higher sensitivity of the LED scanner in the green channel. Total dose uncertainty, film response reproducibility and long-term stability of LED scanner are slightly better than those of the CCFL. However, the LED based scanner has a strong non-uniform response, up to 9%, that must be adequately corrected for radiotherapy dosimetry QA. The differences in light emission spectra between LED and CCFL lamps and its potential impact on film-scanner sensitivity suggest that the design of a dedicated flat-bed scanner with LEDs may improve sensitivity and dose uncertainty in radiochromic film dosimetry. Copyright © 2018 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
Comparison of Cyberware PX and PS 3D human head scanners
NASA Astrophysics Data System (ADS)
Carson, Jeremy; Corner, Brian D.; Crockett, Eric; Li, Peng; Paquette, Steven
2008-02-01
A common limitation of laser line three-Dimensional (3D) scanners is the inability to scan objects with surfaces that are either parallel to the laser line or that self-occlude. Filling in missing areas adds some unwanted inaccuracy to the 3D model. Capturing the human head with a Cyberware PS Head Scanner is an example of obtaining a model where the incomplete areas are difficult to fill accurately. The PS scanner uses a single vertical laser line to illuminate the head and is unable to capture data at top of the head, where the line of sight is tangent to the surface, and under the chin, an area occluded by the chin when the subject looks straight forward. The Cyberware PX Scanner was developed to obtain this missing 3D head data. The PX scanner uses two cameras offset at different angles to provide a more detailed head scan that captures surfaces missed by the PS scanner. The PX scanner cameras also use new technology to obtain color maps that are of higher resolution than the PS Scanner. The two scanners were compared in terms of amount of surface captured (surface area and volume) and the quality of head measurements when compared to direct measurements obtained through standard anthropometry methods. Relative to the PS scanner, the PX head scans were more complete and provided the full set of head measurements, but actual measurement values, when available from both scanners, were about the same.
Evaluation of Potential Damage to Unconventional Structures by Sonic Booms
1990-05-01
plaster and gypsum board caused by sonic boom is broken...on wood lath 3.3 5.6 2. Plaster on gyplath 7.5 16 3. Plaster on expanded metal lath 16 16 4. Plaster on concrete block 16 16 5. Gypsum board (new) 16... wallboard (also called plasterboard or drywall), it is assumed that interior walls of unconventional historic wood frame buildings used plaster instead.
ERIC Educational Resources Information Center
Connors, Shawn M.
Unconventional advice to help college graduates be successful is offered. Ways to find sources of money (i.e., jobs) are described, including: using services or products offered through the mail, making phone calls to build a network of contacts in a particular industry, attending seminars to further one's knowledge of a field, learning about…
Unconventional Cyber Warfare: Cyber Opportunities in Unconventional Warfare
2014-06-01
thanks to Tunisia’s modern communications infrastructure , pervasive Internet, and mobile phone network.”151 Although the use of information and...and physical space. Tunisia had a well-developed mobile phone and Internet infrastructure with nearly nine out of 10 Tunisians owning a mobile phone...OF TABLES Table 1. Top 20 countries of mobile phones per 100 people .........................................60 Table 2. Top 20 countries by number
NASA Astrophysics Data System (ADS)
Chabdarov, Shamil M.; Nadeev, Adel F.; Chickrin, Dmitry E.; Faizullin, Rashid R.
2011-04-01
In this paper we discuss unconventional detection technique also known as «full resolution receiver». This receiver uses Gaussian probability mixtures for interference structure adaptation. Full resolution receiver is alternative to conventional matched filter receivers in the case of non-Gaussian interferences. For the DS-CDMA forward channel with presence of complex interferences sufficient performance increasing was shown.
Unconventional Warfare in the American Civil War
2004-06-18
Miller Thesis Title: Unconventional Warfare in the American Civil War Approved by: , Thesis Committee Chair LTC ( R ) Gregory T. Beck...M.A. , Member LTC ( R ) Richard Barbuto, Ph.D. , Consulting Faculty LTC ( R ) James B. Martin, Ph.D. Accepted this 18th day of...troops and supplies to forward areas. In official correspondence dated 26 May 1864 from Captain A. V. Barringer , Chief Quartermaster, Department of West
NASA Astrophysics Data System (ADS)
Pishtshev, A.; Karazhanov, S. Zh.
2017-02-01
Based on the combination of density functional theory and theory-group methods, we performed systematic modeling of γ-CuI structural design at the atomistic level. Being started from the metallic copper lattice, we treated a crystal assembly as a stepwise iodination process characterized in terms of a sequence of intermediate lattice geometries. These geometries were selected and validated via screening of possible structural transformations. The genesis of chemical bonding was studied for three structural transformations by analyzing the relevant changes in the topology of valence electron densities. We determined structural trends driven by metal-ligand coupling. This allowed us to suggest the improved scenario of chemical bonding in γ-CuI. In particular, the unconventional effect of spatial separation of metallic and covalent interactions was found to be very important with respect to the preferred arrangements of valence electrons in the iodination process. We rigorously showed that useful electronic and optical properties of γ-CuI originate from the combination of two separated bonding patterns—strong covalency established in I-Cu tetrahedral connections and noncovalent interactions of copper cores is caused by the 3d10 closed-shell electron configurations. The other finding of ours is that the self-consistency of the GW calculations is crucial for correctly determining the dynamic electronic correlations in γ-CuI. Detail reinvestigation of the quasi-particle energy structure by means of the self-consistent GW approach allowed us to explain how p-type electrical conductivity can be engineered in the material.
Monte Carlo simulation of efficient data acquisition for an entire-body PET scanner
NASA Astrophysics Data System (ADS)
Isnaini, Ismet; Obi, Takashi; Yoshida, Eiji; Yamaya, Taiga
2014-07-01
Conventional PET scanners can image the whole body using many bed positions. On the other hand, an entire-body PET scanner with an extended axial FOV, which can trace whole-body uptake images at the same time and improve sensitivity dynamically, has been desired. The entire-body PET scanner would have to process a large amount of data effectively. As a result, the entire-body PET scanner has high dead time at a multiplex detector grouping process. Also, the entire-body PET scanner has many oblique line-of-responses. In this work, we study an efficient data acquisition for the entire-body PET scanner using the Monte Carlo simulation. The simulated entire-body PET scanner based on depth-of-interaction detectors has a 2016-mm axial field-of-view (FOV) and an 80-cm ring diameter. Since the entire-body PET scanner has higher single data loss than a conventional PET scanner at grouping circuits, the NECR of the entire-body PET scanner decreases. But, single data loss is mitigated by separating the axially arranged detector into multiple parts. Our choice of 3 groups of axially-arranged detectors has shown to increase the peak NECR by 41%. An appropriate choice of maximum ring difference (MRD) will also maintain the same high performance of sensitivity and high peak NECR while at the same time reduces the data size. The extremely-oblique line of response for large axial FOV does not contribute much to the performance of the scanner. The total sensitivity with full MRD increased only 15% than that with about half MRD. The peak NECR was saturated at about half MRD. The entire-body PET scanner promises to provide a large axial FOV and to have sufficient performance values without using the full data.
Jun, Sanghoon; Kim, Namkug; Seo, Joon Beom; Lee, Young Kyung; Lynch, David A
2017-12-01
We propose the use of ensemble classifiers to overcome inter-scanner variations in the differentiation of regional disease patterns in high-resolution computed tomography (HRCT) images of diffuse interstitial lung disease patients obtained from different scanners. A total of 600 rectangular 20 × 20-pixel regions of interest (ROIs) on HRCT images obtained from two different scanners (GE and Siemens) and the whole lung area of 92 HRCT images were classified as one of six regional pulmonary disease patterns by two expert radiologists. Textual and shape features were extracted from each ROI and the whole lung parenchyma. For automatic classification, individual and ensemble classifiers were trained and tested with the ROI dataset. We designed the following three experimental sets: an intra-scanner study in which the training and test sets were from the same scanner, an integrated scanner study in which the data from the two scanners were merged, and an inter-scanner study in which the training and test sets were acquired from different scanners. In the ROI-based classification, the ensemble classifiers showed better (p < 0.001) accuracy (89.73%, SD = 0.43) than the individual classifiers (88.38%, SD = 0.31) in the integrated scanner test. The ensemble classifiers also showed partial improvements in the intra- and inter-scanner tests. In the whole lung classification experiment, the quantification accuracies of the ensemble classifiers with integrated training (49.57%) were higher (p < 0.001) than the individual classifiers (48.19%). Furthermore, the ensemble classifiers also showed better performance in both the intra- and inter-scanner experiments. We concluded that the ensemble classifiers provide better performance when using integrated scanner images.
High throughput laser processing
DOE Office of Scientific and Technical Information (OSTI.GOV)
Harley, Gabriel; Pass, Thomas; Cousins, Peter John
A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.
Fabrication of paper-based analytical devices optimized by central composite design.
Hamedpour, Vahid; Leardi, Riccardo; Suzuki, Koji; Citterio, Daniel
2018-04-30
In this work, an application of a design of experiments approach for the optimization of an isoniazid assay on a single-area inkjet-printed paper-based analytical device (PAD) is described. For this purpose, a central composite design was used for evaluation of the effect of device geometry and amount of assay reagents on the efficiency of the proposed device. The factors of interest were printed length, width, and sampling volume as factors related to device geometry, and amounts of the assay reagents polyvinyl alcohol (PVA), NH4OH, and AgNO3. Deposition of the assay reagents was performed by a thermal inkjet printer. The colorimetric assay mechanism of this device is based on the chemical interaction of isoniazid, ammonium hydroxide, and PVA with silver ions to induce the formation of yellow silver nanoparticles (AgNPs). The in situ-formed AgNPs can be easily detected by the naked eye or with a simple flat-bed scanner. Under optimal conditions, the calibration curve was linear in the isoniazid concentration range 0.03-10 mmol L-1 with a relative standard deviation of 3.4% (n = 5 for determination of 1.0 mmol L-1). Finally, the application of the proposed device for isoniazid determination in pharmaceutical preparations produced satisfactory results.
Skokauskas, Norbert; Carballedo, Angela; Fagan, Andrew; Frodl, Thomas
2015-10-01
Victims of child sexual abuse can develop depression and other mental health conditions that follow them well into adulthood. This study aimed to clarify the role of sexual abuse (SA) on functional imaging markers associated with MDD. Thirty-seven patients with MDD only; and 13 patients with both MDD and SA and 43 healthy controls performed emotional attention shifting tasks during fMRI session. Clinical diagnoses were made by consultant psychiatrists based on the DSM-IV-TR criteria and diagnoses were confirmed using SCID-I. Magnetic resonance images were obtained with a Philips Achieva 3 Tesla MRI scanner. Short form childhood trauma questionnaire, Hamilton Rating Scale for Depression and Beck's Depression Inventory were also employed. Data were analysed with Statistical Parametric Mapping 8 (SPM8). Using the contrast judgment of emotion minus judgment of geometry following emotional neutral stimuli, patients with MDD showed significantly reduced activation in comparison to healthy controls in the area of the right fusiform gyrus. With the contrast judgment of emotion minus judgment of geometry following emotional negative stimuli, participants with MDD and SA showed significantly higher activation in the area of the left inferior parietal lobe in comparison to participants with MDD without SA. The history of sexual abuse affects functional neuroimaging markers associated with major depressive disorder.
Unconventional gas development facilitates plant invasions.
Barlow, Kathryn M; Mortensen, David A; Drohan, Patrick J; Averill, Kristine M
2017-11-01
Vegetation removal and soil disturbance from natural resource development, combined with invasive plant propagule pressure, can increase vulnerability to plant invasions. Unconventional oil and gas development produces surface disturbance by way of well pad, road, and pipeline construction, and increased traffic. Little is known about the resulting impacts on plant community assembly, including the spread of invasive plants. Our work was conducted in Pennsylvania forests that overlay the Marcellus and Utica shale formations to determine if invasive plants have spread to edge habitat created by unconventional gas development and to investigate factors associated with their presence. A piecewise structural equation model was used to determine the direct and indirect factors associated with invasive plant establishment on well pads. The model included the following measured or calculated variables: current propagule pressure on local access roads, the spatial extent of the pre-development road network (potential source of invasive propagules), the number of wells per pad (indicator of traffic density), and pad age. Sixty-one percent of the 127 well pads surveyed had at least one invasive plant species present. Invasive plant presence on well pads was positively correlated with local propagule pressure on access roads and indirectly with road density pre-development, the number of wells, and age of the well pad. The vast reserves of unconventional oil and gas are in the early stages of development in the US. Continued development of this underground resource must be paired with careful monitoring and management of surface ecological impacts, including the spread of invasive plants. Prioritizing invasive plant monitoring in unconventional oil and gas development areas with existing roads and multi-well pads could improve early detection and control of invasive plants. Copyright © 2017 Elsevier Ltd. All rights reserved.
Lee, Jung Yeon; Brook, Judith S; Pahl, Kerstin; Brook, David W
2017-11-01
A quarter of people living with human immunodeficiency virus (HIV) infection in the United States are women. Furthermore, African American and Hispanic/Latina women continue to be disproportionately affected by HIV, compared with women of other races/ethnicities. Cannabis use prior to intercourse may be associated with increased risky sexual behaviors which are highly related to HIV. The ultimate goal of this research is to better understand the relationships between unconventional personal attributes (e.g., risk-taking behaviors) in the late 20s, substance use (e.g., alcohol) in the mid 30s, and cannabis use prior to intercourse in the late 30s using a community sample; such an understanding may inform interventions. This study employing data from the Harlem Longitudinal Development Study includes 343 female participants (50% African Americans, 50% Puerto Ricans). Structural equation modeling indicated that unconventional personal attributes in the late 20s were associated with substance use in the mid 30s (β=0.32, p<0.001), which in turn, was associated with cannabis use prior to sexual intercourse in the late 30s (β=0.64, p<0.001). Unconventional personal attributes in the late 20s were also directly related to cannabis use prior to sexual intercourse in the late 30s (β=0.39, p<0.01). The findings of this study suggest that interventions focused on decreasing unconventional personal attributes as well as substance use may reduce sexual risk behaviors among urban African American and Puerto Rican women. Also, the implications of this study for health care providers and researchers working in HIV prevention are that these precursors may be useful as patient screening tools. Copyright © 2017 Elsevier Ltd. All rights reserved.
Turyk, Zofia; Osek, Maria; Olkowski, Bogusław; Janocha, Alina
2014-01-01
This study examined carcass and meat quality parameters in growing/finishing pigs fed unconventionally versus the concentrate-based system. Ninety-six, 12 wk old pigs (34±SD 0.3 kg) were randomly divided into three groups, assigned to one of the three dietary treatments: standard complete concentrate mixture, conventional (C diet); unconventional, steamed potato-green forage-concentrate based diet (U diet), and unconventional basal diet+herbage mix (UH diet). Pigs fed U diet showed lower dressing percentage, meatiness, loin eye area, and weight of pork neck (p≤0.05), but their carcasses were significantly (p≤0.05) longer and had increased backfat depth (p≤0.05). There was no impact of the diet on the meat content of dry matter, crude ash, acidity, and colour parameters of m. longissimus. Unconventional feeding significantly (p≤0.05) elevated water the holding capacity of m. longissimus and slightly improved the sensory attributes analysis of meat. The addition of herbs resulted in increased loin eye area (p≤0.05), decreased fat content (p≤0.05) in m. longissimus, and tended to improve some sensory attributes of meat. There were significant gender differences in response to all diets. There were significant diet×sex interactions for some measured variables, but there were no clearly identifiable trends with regard to any specific carcass or meat parameters. Feeding unconventional diet to pigs may offer better culinary attributes of the meat, and improve some technologically important characteristics of pig carcass, but may negatively affect some carcass or meat parameters. PMID:25050003
Sarcomeric Myosin Expression in the Tongue Body of Humans, Macaques and Rats
Rahnert, Jill A.; Sokoloff, Alan J.; Burkholder, Thomas J.
2010-01-01
Expression of developmental and unconventional myosin heavy chain (MHC) isoforms in some adult head and neck muscles is thought to reflect specific contractile demands of muscle fibers active during kinematically complex movements. Mammalian tongue muscles are active during oromotor behaviors that encompass a wide range of tongue movement speeds and tongue shape changes (e.g. respiration, oral transport, swallowing, rejection), but the extent to which tongue muscles express developmental and unconventional MHC is not known. Quantitative PCR was used to determine the mRNA content of conventional MHC-beta, MHC-2a, MHC-2b and MHC-2x, the developmental isoforms embryonic MHC and neonatal MHC and the unconventional isoforms atrial/cardiac-α MHC (MHC-alpha), extraocular MHC, masseter MHC and slow tonic MHC in tongue body muscles of the rat, macaque and human. In all species, conventional MHC isoforms predominate. MHC-2b and MHC-2x account for 98% of total MHC mRNA in the rat. MHC-2a, MHC-2x and MHC-beta account for 94% of total MHC mRNA in humans and 96% of total MHC mRNA in macaque. With the exception of MHC-alpha in humans (5%), developmental and unconventional MHC mRNA represents less than 0.3% of total MHC mRNA. We conclude that in these species, there is limited expression of developmental and unconventional MHC and that diversity of tongue body muscle fiber contractile properties is achieved primarily by MHC-beta, MHC-2a, MHC-2x and MHC-2b. Whether expression of MHC-alpha mRNA in tongue is unique to humans or present in other hominoids awaits further investigation. PMID:19907142
Water Issues Associated with Increasing Unconventional Oil Production in the Permian Basin
NASA Astrophysics Data System (ADS)
Reedy, R. C.; Scanlon, B. R.; Male, F.; Walsh, M.
2017-12-01
The Permian Basin is being transformed from a major conventional oil play to the world's largest unconventional play; however, managing water for this transition is critical in this semiarid region. The study included quantifying produced water volumes with oil and gas production along with water demands for hydraulic fracturing using a detailed well-by-well analysis. Our results show that oil wells in conventional reservoirs generate large volumes of produced water relative to oil production with produced water to oil ratios of 13 (i.e. 13 barrels [bbl] of water relative to a bbl of oil). However, produced water from conventional reservoirs has been mostly injected back into the pressure-depleted oil-producing reservoirs for enhanced oil recovery using water flooding. Unconventional horizontal wells use large volumes of water for hydraulic fracturing that has been markedly increasing by factors of 10 - 16 per well and by factors of 7-10 after dividing by lateral well length (2008-2015). Although unconventional wells generate less produced water relative to oil ( 3 bbl of water relative to oil) than conventional wells, the main difference is that this produced water cannot be reinjected into the low permeability shale reservoirs. Instead, the produced water is disposed into non-producing geologic zones that could result in overpressuring and induced seismicity. There is a high potential for reusing produced water from unconventional wells in the Permian Basin because the produced water volumes can support the hydraulic fracturing water demand based on 2014 data. Reusing produced water with minimal water treatment (clean brine) could partially mitigate produced water injection concerns while reducing water demand for hydraulic fracturing.
Complete-arch accuracy of intraoral scanners.
Treesh, Joshua C; Liacouras, Peter C; Taft, Robert M; Brooks, Daniel I; Raiciulescu, Sorana; Ellert, Daniel O; Grant, Gerald T; Ye, Ling
2018-04-30
Intraoral scanners have shown varied results in complete-arch applications. The purpose of this in vitro study was to evaluate the complete-arch accuracy of 4 intraoral scanners based on trueness and precision measurements compared with a known reference (trueness) and with each other (precision). Four intraoral scanners were evaluated: CEREC Bluecam, CEREC Omnicam, TRIOS Color, and Carestream CS 3500. A complete-arch reference cast was created and printed using a 3-dimensional dental cast printer with photopolymer resin. The reference cast was digitized using a laboratory-based white light 3-dimensional scanner. The printed reference cast was scanned 10 times with each intraoral scanner. The digital standard tessellation language (STL) files from each scanner were then registered to the reference file and compared with differences in trueness and precision using a 3-dimensional modeling software. Additionally, scanning time was recorded for each scan performed. The Wilcoxon signed rank, Kruskal-Wallis, and Dunn tests were used to detect differences for trueness, precision, and scanning time (α=.05). Carestream CS 3500 had the lowest overall trueness and precision compared with Bluecam and TRIOS Color. The fourth scanner, Omnicam, had intermediate trueness and precision. All of the scanners tended to underestimate the size of the reference file, with exception of the Carestream CS 3500, which was more variable. Based on visual inspection of the color rendering of signed differences, the greatest amount of error tended to be in the posterior aspects of the arch, with local errors exceeding 100 μm for all scans. The single capture scanner Carestream CS 3500 had the overall longest scan times and was significantly slower than the continuous capture scanners TRIOS Color and Omnicam. Significant differences in both trueness and precision were found among the scanners. Scan times of the continuous capture scanners were faster than the single capture scanners. Published by Elsevier Inc.
Spectral characterization of the LANDSAT-D multispectral scanner subsystems
NASA Technical Reports Server (NTRS)
Markham, B. L. (Principal Investigator); Barker, J. L.
1982-01-01
Relative spectral response data for the multispectral scanner subsystems (MSS) to be flown on LANDSAT-D and LANDSAT-D backup, the protoflight and flight models, respectively, are presented and compared to similar data for the Landsat 1,2, and 3 subsystems. Channel-bychannel (six channels per band) outputs for soil and soybean targets were simulated and compared within each band and between scanners. The two LANDSAT-D scanners proved to be nearly identical in mean spectral response, but they exhibited some differences from the previous MSS's. Principal differences between the spectral responses of the D-scanners and previous scanners were: (1) a mean upper-band edge in the green band of 606 nm compared to previous means of 593 to 598 nm; (2) an average upper-band edge of 697 nm in the red band compared to previous averages of 701 to 710 nm; and (3) an average bandpass for the first near-IR band of 702-814 nm compared to a range of 693-793 to 697-802 nm for previous scanners. These differences caused the simulated D-scanner outputs to be 3 to 10 percent lower in the red band and 3 to 11 percent higher in the first near-IR band than previous scanners for the soybeans target. Otherwise, outputs from soil and soybean targets were only slightly affected. The D-scanners were generally more uniform from channel to channel within bands than previous scanners.
Performance of an improved first generation optical CT scanner for 3D dosimetry
NASA Astrophysics Data System (ADS)
Qian, Xin; Adamovics, John; Wuu, Cheng-Shie
2013-12-01
Performance analysis of a modified 3D dosimetry optical scanner based on the first generation optical CT scanner OCTOPUS is presented. The system consists of PRESAGE™ dosimeters, the modified 3D scanner, and a new developed in-house user control panel written in Labview program which provides more flexibility to optimize mechanical control and data acquisition technique. The total scanning time has been significantly reduced from initial 8 h to ∼2 h by using the modified scanner. The functional performance of the modified scanner has been evaluated in terms of the mechanical integrity uncertainty of the data acquisition process. Optical density distribution comparison between the modified scanner, OCTOPUS and the treatment plan system has been studied. It has been demonstrated that the agreement between the modified scanner and treatment plans is comparable with that between the OCTOPUS and treatment plans.
Unconventional energy resources: 2007-2008 review
Warwick, Peter D.; ,
2009-01-01
This paper summarizes five 2007–2008 resource commodity committee reports prepared by the Energy Minerals Division (EMD) of the American Association of Petroleum Geologists. Current United States and global research and development activities related to gas hydrates, gas shales, geothermal resources, oil sands, and uranium resources are included in this review. These commodity reports were written to advise EMD leadership and membership of the current status of research and development of unconventional energy resources. Unconventional energy resources are defined as those resources other than conventional oil and natural gas that typically occur in sandstone and carbonate rocks. Gas hydrate resources are potentially enormous; however, production technologies are still under development. Gas shale, geothermal, oil sand, and uranium resources are now increasing targets of exploration and development, and are rapidly becoming important energy resources that will continue to be developed in the future.
Magnetic Field Enhanced Superconductivity in Epitaxial Thin Film WTe2.
Asaba, Tomoya; Wang, Yongjie; Li, Gang; Xiang, Ziji; Tinsman, Colin; Chen, Lu; Zhou, Shangnan; Zhao, Songrui; Laleyan, David; Li, Yi; Mi, Zetian; Li, Lu
2018-04-25
In conventional superconductors an external magnetic field generally suppresses superconductivity. This results from a simple thermodynamic competition of the superconducting and magnetic free energies. In this study, we report the unconventional features in the superconducting epitaxial thin film tungsten telluride (WTe 2 ). Measuring the electrical transport properties of Molecular Beam Epitaxy (MBE) grown WTe 2 thin films with a high precision rotation stage, we map the upper critical field H c2 at different temperatures T. We observe the superconducting transition temperature T c is enhanced by in-plane magnetic fields. The upper critical field H c2 is observed to establish an unconventional non-monotonic dependence on temperature. We suggest that this unconventional feature is due to the lifting of inversion symmetry, which leads to the enhancement of H c2 in Ising superconductors.
CT cardiac imaging: evolution from 2D to 3D backprojection
NASA Astrophysics Data System (ADS)
Tang, Xiangyang; Pan, Tinsu; Sasaki, Kosuke
2004-04-01
The state-of-the-art multiple detector-row CT, which usually employs fan beam reconstruction algorithms by approximating a cone beam geometry into a fan beam geometry, has been well recognized as an important modality for cardiac imaging. At present, the multiple detector-row CT is evolving into volumetric CT, in which cone beam reconstruction algorithms are needed to combat cone beam artifacts caused by large cone angle. An ECG-gated cardiac cone beam reconstruction algorithm based upon the so-called semi-CB geometry is implemented in this study. To get the highest temporal resolution, only the projection data corresponding to 180° plus the cone angle are row-wise rebinned into the semi-CB geometry for three-dimensional reconstruction. Data extrapolation is utilized to extend the z-coverage of the ECG-gated cardiac cone beam reconstruction algorithm approaching the edge of a CT detector. A helical body phantom is used to evaluate the ECG-gated cone beam reconstruction algorithm"s z-coverage and capability of suppressing cone beam artifacts. Furthermore, two sets of cardiac data scanned by a multiple detector-row CT scanner at 16 x 1.25 (mm) and normalized pitch 0.275 and 0.3 respectively are used to evaluate the ECG-gated CB reconstruction algorithm"s imaging performance. As a reference, the images reconstructed by a fan beam reconstruction algorithm for multiple detector-row CT are also presented. The qualitative evaluation shows that, the ECG-gated cone beam reconstruction algorithm outperforms its fan beam counterpart from the perspective of cone beam artifact suppression and z-coverage while the temporal resolution is well maintained. Consequently, the scan speed can be increased to reduce the contrast agent amount and injection time, improve the patient comfort and x-ray dose efficiency. Based up on the comparison, it is believed that, with the transition of multiple detector-row CT into volumetric CT, ECG-gated cone beam reconstruction algorithms will provide better image quality for CT cardiac applications.
NASA Astrophysics Data System (ADS)
Wen, Gezheng; Markey, Mia K.; Miner Haygood, Tamara; Park, Subok
2018-02-01
Model observers are widely used in task-based assessments of medical image quality. The presence of multiple abnormalities in a single set of images, such as in multifocal multicentric breast cancer (MFMC), has an immense clinical impact on treatment planning and survival outcomes. Detecting multiple breast tumors is challenging as MFMC is relatively uncommon, and human observers do not know the number or locations of tumors a priori. Digital breast tomosynthesis (DBT), in which an x-ray beam sweeps over a limited angular range across the breast, has the potential to improve the detection of multiple tumors. However, prior studies of DBT image quality all focus on unifocal breast cancers. In this study, we extended our 2D multi-lesion (ML) channelized Hotelling observer (CHO) into a 3D ML-CHO that detects multiple lesions from volumetric imaging data. Then we employed the 3D ML-CHO to identify optimal DBT acquisition geometries for detection of MFMC. Digital breast phantoms with multiple embedded synthetic lesions were scanned by simulated DBT scanners of different geometries (wide/narrow angular span, different number of projections per scan) to simulate MFMC cases. With new implementations of 3D partial least squares (PLS) and modified Laguerre-Gauss (LG) channels, the 3D ML-CHO made detection decisions based upon the overall information from individual DBT slices and their correlations. Our evaluation results show that: (1) the 3D ML-CHO could achieve good detection performance with a small number of channels, and 3D PLS channels on average outperform the counterpart LG channels; (2) incorporating locally varying anatomical backgrounds and their correlations as in the 3D ML-CHO is essential for multi-lesion detection; (3) the most effective DBT geometry for detection of MFMC may vary when the task of clinical interest changes, and a given DBT geometry may not yield images that are equally informative for detecting MF, MC, and unifocal cancers.
A comparative evaluation of intraoral and extraoral digital impressions: An in vivo study.
Sason, Gursharan Kaur; Mistry, Gaurang; Tabassum, Rubina; Shetty, Omkar
2018-01-01
The accuracy of a dental impression is determined by two factors: "trueness" and "precision." The scanners used in dentistry are relatively new in market, and very few studies have compared the "precision" and "trueness" of intraoral scanner with the extraoral scanner. The aim of this study was to evaluate and compare accuracy of intraoral and extraoral digital impressions. Ten dentulous participants (male/female) aged 18-45 years with an asymptomatic endodontically treated mandibular first molars with adjacent teeth present were selected for this study. The prepared test tooth was measured using a digital Vernier caliper to obtain reference datasets. The tooth was then scanned using the intraoral scanner, and the extraoral scans were obtained using the casts made from the impressions. The datasets were divided into four groups and then statistically analyzed. The test tooth preparation was done, and dimples were made using a round diamond point on the bucco-occlusal, mesio-occlusal, disto-occlusal, and linguo-occlusal lines angles, and these were used to obtain reference datasets intraorally using a digital Vernier caliper. The test tooth was then scanned with the IO scanner (CS 3500, Carestream dental) thrice and also impressions were made using addition silicone impression material (3M™ ESPE) and dental casts were poured in Type IV dental stone (Kalrock-Kalabhai Karson India Pvt. Ltd., India) which were later scanned with the EO scanner (LAVA™ Scan ST Design system [3M™ ESPE]) thrice. The Datasets obtained from Intraoral and Extraoral scanner were exported to Dental Wings software and readings were obtained. Repeated measures ANOVA test was used to compare differences between the groups and independent t -test for comparison between the readings of intraoral and extraoral scanner. Least significant difference test was used for comparison between reference datasets with intraoral and extraoral scanner, respectively. A level of statistical significance of P < 0.05 was set. The precision values ranged from 20.7 to 33.35 μm for intraoral scanner and 19.5 to 37 μm for extraoral scanner. The mean deviations for intraoral scanner were 19.6 μm mesiodistally (MD) and 16.4 μm buccolingually (BL) and 24.0 μm MD and 22.5 μm BL for extraoral scanner. The mean values of the intraoral scanner (413 μm) for trueness were closest to the actual measurements (459 μm) than the extraoral scanner (396 μm). The intraoral scanner showed higher "precision" and "trueness" values when compared with the extraoral scanner.
You, Fangjie; Xu, Yanchao; Yang, Xiaobin; Zhang, Yanqiu; Shao, Lu
2017-06-01
A novel Ni 2+ -polyphenol network was designed as an excellent bio-coating by a one-step strategy to obtain nanofiltration membranes, possessing unconventional high water flux up to 56.1 L m -2 h -1 bar -1 with rose bengal (RB) rejection above 95%. This study provides a facile approach to prepare highly-efficient nanofiltration membranes for wastewater remediation.
Sub state Unconventional Warfare: Expanding United States Military Political Options
2016-05-26
phases due to competing incumbent efforts. Giap was influenced in his understanding of revolutionary war phasing by Sun Tzu who Giap called one of his...Challenge of Unconventional Warfare. London: Routledge, 2012. Ames, Roger T. Sun - Tzu The Art of Warfare. New York: Ballantine Books, 1993. Amin, Samir...Guerrilla: Insurgents, Patriots, and Terrorists from Sun Tzu to Bin Laden. London: Brassey’s Inc., 2004. Rosenau, William, Subversion and Insurgency
Quantitative mass spectrometry of unconventional human biological matrices
NASA Astrophysics Data System (ADS)
Dutkiewicz, Ewelina P.; Urban, Pawel L.
2016-10-01
The development of sensitive and versatile mass spectrometric methodology has fuelled interest in the analysis of metabolites and drugs in unconventional biological specimens. Here, we discuss the analysis of eight human matrices-hair, nail, breath, saliva, tears, meibum, nasal mucus and skin excretions (including sweat)-by mass spectrometry (MS). The use of such specimens brings a number of advantages, the most important being non-invasive sampling, the limited risk of adulteration and the ability to obtain information that complements blood and urine tests. The most often studied matrices are hair, breath and saliva. This review primarily focuses on endogenous (e.g. potential biomarkers, hormones) and exogenous (e.g. drugs, environmental contaminants) small molecules. The majority of analytical methods used chromatographic separation prior to MS; however, such a hyphenated methodology greatly limits analytical throughput. On the other hand, the mass spectrometric methods that exclude chromatographic separation are fast but suffer from matrix interferences. To enable development of quantitative assays for unconventional matrices, it is desirable to standardize the protocols for the analysis of each specimen and create appropriate certified reference materials. Overcoming these challenges will make analysis of unconventional human biological matrices more common in a clinical setting. This article is part of the themed issue 'Quantitative mass spectrometry'.
A methodology for the optimisation of a mm-wave scanner
NASA Astrophysics Data System (ADS)
Stec, L. Zoë; Podd, Frank J. W.; Peyton, Anthony J.
2016-10-01
The need to detect non-metallic items under clothes to prevent terrorism at transport hubs is becoming vital. Millimetre wave technology is able to penetrate clothing, yet able to interact with objects concealed underneath. This paper considers active illumination using multiple transmitter and receiver antennas. The positioning of these antennas must achieve full body coverage, whilst minimising the number of antenna elements and the number of required measurements. It sets out a rapid simulation methodology, based on the Kirchhoff equations, to explore different scenarios for scanner architecture optimisation. The paper assumes that the electromagnetic waves used are at lower frequencies (say, 10-30 GHz) where the body temperature does not need to be considered. This range allows better penetration of clothing than higher frequencies, yet still provides adequate resolution. Since passengers vary greatly in shape and size, the system needs to be able to work well with a range of body morphologies. Thus we have used two very differently shaped avatars to test the portal simulations. This simulation tool allows many different avatars to be generated quickly. Findings from these simulations indicated that the dimensions of the avatar did indeed have an effect on the pattern of illumination, and that the data for each antenna pair can easily be combined to compare different antenna geometries for a given portal architecture, resulting in useful insights into antenna placement. The data generated could be analysed both quantitatively and qualitatively, at various levels of scale.
NASA Astrophysics Data System (ADS)
Rulaidi, W. E. P.; Huri, M. S. N.; Ng, K. H.
2017-05-01
One method to optimise the use of x-rays in CT and hence a reduction in patient dose is the application of automatic exposure control (AEC). This study measured the effective mAs, image noise and volume CT dose index (CTDIvol) as the result of changing the AEC index on a Siemens Somatom Definition 64 slices dual source CT scanner. The scans were performed on four phantoms of different geometries, namely the 16 and 32 cm cylindrical CTDI phantoms and two anthropomorphic phantoms, RANDO (20 cm effective diameter) and ATOM (19.8 cm effective diameter). Results showed that the effective mAs increased with increasing tube potential (kVp) and Quality Reference mAs (QRM), therefore increasing CTDIvol while reducing image noise. Meanwhile, no changes of radiation dose and image noise were observed when the pitch was increased. However, for the largest phantom (32 cm effective diameter), a constant effective mAs was found between 120 and 140 kVp. The same trend was also found with increasing QRM from 300 mAs to 400 mAs suggesting a certain limitation of the AEC has been reached. In conclusion, this study showed that AEC is affected by kVp and QRM but not by pitch selection. Further work is required to quantify the characteristics of the AEC system in relation to the mentioned parameters for better optimisation.
Learning-based 3D surface optimization from medical image reconstruction
NASA Astrophysics Data System (ADS)
Wei, Mingqiang; Wang, Jun; Guo, Xianglin; Wu, Huisi; Xie, Haoran; Wang, Fu Lee; Qin, Jing
2018-04-01
Mesh optimization has been studied from the graphical point of view: It often focuses on 3D surfaces obtained by optical and laser scanners. This is despite the fact that isosurfaced meshes of medical image reconstruction suffer from both staircases and noise: Isotropic filters lead to shape distortion, while anisotropic ones maintain pseudo-features. We present a data-driven method for automatically removing these medical artifacts while not introducing additional ones. We consider mesh optimization as a combination of vertex filtering and facet filtering in two stages: Offline training and runtime optimization. In specific, we first detect staircases based on the scanning direction of CT/MRI scanners, and design a staircase-sensitive Laplacian filter (vertex-based) to remove them; and then design a unilateral filtered facet normal descriptor (uFND) for measuring the geometry features around each facet of a given mesh, and learn the regression functions from a set of medical meshes and their high-resolution reference counterparts for mapping the uFNDs to the facet normals of the reference meshes (facet-based). At runtime, we first perform staircase-sensitive Laplacian filter on an input MC (Marching Cubes) mesh, and then filter the mesh facet normal field using the learned regression functions, and finally deform it to match the new normal field for obtaining a compact approximation of the high-resolution reference model. Tests show that our algorithm achieves higher quality results than previous approaches regarding surface smoothness and surface accuracy.
Quality Assessment and Comparison of Smartphone and Leica C10 Laser Scanner Based Point Clouds
NASA Astrophysics Data System (ADS)
Sirmacek, Beril; Lindenbergh, Roderik; Wang, Jinhu
2016-06-01
3D urban models are valuable for urban map generation, environment monitoring, safety planning and educational purposes. For 3D measurement of urban structures, generally airborne laser scanning sensors or multi-view satellite images are used as a data source. However, close-range sensors (such as terrestrial laser scanners) and low cost cameras (which can generate point clouds based on photogrammetry) can provide denser sampling of 3D surface geometry. Unfortunately, terrestrial laser scanning sensors are expensive and trained persons are needed to use them for point cloud acquisition. A potential effective 3D modelling can be generated based on a low cost smartphone sensor. Herein, we show examples of using smartphone camera images to generate 3D models of urban structures. We compare a smartphone based 3D model of an example structure with a terrestrial laser scanning point cloud of the structure. This comparison gives us opportunity to discuss the differences in terms of geometrical correctness, as well as the advantages, disadvantages and limitations in data acquisition and processing. We also discuss how smartphone based point clouds can help to solve further problems with 3D urban model generation in a practical way. We show that terrestrial laser scanning point clouds which do not have color information can be colored using smartphones. The experiments, discussions and scientific findings might be insightful for the future studies in fast, easy and low-cost 3D urban model generation field.
Beld, E; Seevinck, P R; Lagendijk, J J W; Viergever, M A; Moerland, M A
2016-09-21
In the process of developing a robotic MRI-guided high-dose-rate (HDR) prostate brachytherapy treatment, the influence of the MRI scanner's magnetic field on the dose distribution needs to be investigated. A magnetic field causes a deflection of electrons in the plane perpendicular to the magnetic field, and it leads to less lateral scattering along the direction parallel with the magnetic field. Monte Carlo simulations were carried out to determine the influence of the magnetic field on the electron behavior and on the total dose distribution around an Ir-192 source. Furthermore, the influence of air pockets being present near the source was studied. The Monte Carlo package Geant4 was utilized for the simulations. The simulated geometries consisted of a simplified point source inside a water phantom. Magnetic field strengths of 0 T, 1.5 T, 3 T, and 7 T were considered. The simulation results demonstrated that the dose distribution was nearly unaffected by the magnetic field for all investigated magnetic field strengths. Evidence was found that, from a dose perspective, the HDR prostate brachytherapy treatment using Ir-192 can be performed safely inside the MRI scanner. No need was found to account for the magnetic field during treatment planning. Nevertheless, the presence of air pockets in close vicinity to the source, particularly along the direction parallel with the magnetic field, appeared to be an important point for consideration.
D Point Cloud Model Colorization by Dense Registration of Digital Images
NASA Astrophysics Data System (ADS)
Crombez, N.; Caron, G.; Mouaddib, E.
2015-02-01
Architectural heritage is a historic and artistic property which has to be protected, preserved, restored and must be shown to the public. Modern tools like 3D laser scanners are more and more used in heritage documentation. Most of the time, the 3D laser scanner is completed by a digital camera which is used to enrich the accurate geometric informations with the scanned objects colors. However, the photometric quality of the acquired point clouds is generally rather low because of several problems presented below. We propose an accurate method for registering digital images acquired from any viewpoints on point clouds which is a crucial step for a good colorization by colors projection. We express this image-to-geometry registration as a pose estimation problem. The camera pose is computed using the entire images intensities under a photometric visual and virtual servoing (VVS) framework. The camera extrinsic and intrinsic parameters are automatically estimated. Because we estimates the intrinsic parameters we do not need any informations about the camera which took the used digital image. Finally, when the point cloud model and the digital image are correctly registered, we project the 3D model in the digital image frame and assign new colors to the visible points. The performance of the approach is proven in simulation and real experiments on indoor and outdoor datasets of the cathedral of Amiens, which highlight the success of our method, leading to point clouds with better photometric quality and resolution.
Using the ATL HDI 1000 to collect demodulated RF data for monitoring HIFU lesion formation
NASA Astrophysics Data System (ADS)
Anand, Ajay; Kaczkowski, Peter J.; Daigle, Ron E.; Huang, Lingyun; Paun, Marla; Beach, Kirk W.; Crum, Lawrence A.
2003-05-01
The ability to accurately track and monitor the progress of lesion formation during HIFU (High Intensity Focused Ultrasound) therapy is important for the success of HIFU-based treatment protocols. To aid in the development of algorithms for accurately targeting and monitoring formation of HIFU induced lesions, we have developed a software system to perform RF data acquisition during HIFU therapy using a commercially available clinical ultrasound scanner (ATL HDI 1000, Philips Medical Systems, Bothell, WA). The HDI 1000 scanner functions on a software dominant architecture, permitting straightforward external control of its operation and relatively easy access to quadrature demodulated RF data. A PC running a custom developed program sends control signals to the HIFU module via GPIB and to the HDI 1000 via Telnet, alternately interleaving HIFU exposures and RF frame acquisitions. The system was tested during experiments in which HIFU lesions were created in excised animal tissue. No crosstalk between the HIFU beam and the ultrasound imager was detected, thus demonstrating synchronization. Newly developed acquisition modes allow greater user control in setting the image geometry and scanline density, and enables high frame rate acquisition. This system facilitates rapid development of signal-processing based HIFU therapy monitoring algorithms and their implementation in image-guided thermal therapy systems. In addition, the HDI 1000 system can be easily customized for use with other emerging imaging modalities that require access to the RF data such as elastographic methods and new Doppler-based imaging and tissue characterization techniques.
51. View of upper radar scanner switch in radar scanner ...
51. View of upper radar scanner switch in radar scanner building 105 from upper catwalk level showing emanating waveguides from upper switch (upper one-fourth of photograph) and emanating waveguides from lower radar scanner switch in vertical runs. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK
High throughput solar cell ablation system
Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John
2014-10-14
A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.
High throughput solar cell ablation system
Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John
2012-09-11
A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.
NASA Technical Reports Server (NTRS)
Cook, M.
1990-01-01
Qualification testing of Combustion Engineering's AMDATA Intraspect/98 Data Acquisition and Imaging System that applies to the redesigned solid rocket motor field joint capture feature case-to-insulation bondline inspection was performed. Testing was performed at M-111, the Thiokol Corp. Inert Parts Preparation Building. The purpose of the inspection was to verify the integrity of the capture feature area case-to-insulation bondline. The capture feature scanner was calibrated over an intentional 1.0 to 1.0 in. case-to-insulation unbond. The capture feature scanner was then used to scan 60 deg of a capture feature field joint. Calibration of the capture feature scanner was then rechecked over the intentional unbond to ensure that the calibration settings did not change during the case scan. This procedure was successfully performed five times to qualify the unbond detection capability of the capture feature scanner. The capture feature scanner qualified in this test contains many points of mechanical instability that can affect the overall ultrasonic signal response. A new generation scanner, designated the sigma scanner, should be implemented to replace the current configuration scanner. The sigma scanner eliminates the unstable connection points of the current scanner and has additional inspection capabilities.
Giannelli, Marco; Diciotti, Stefano; Tessa, Carlo; Mascalchi, Mario
2010-01-01
Although in EPI-fMRI analyses typical acquisition parameters (TR, TE, matrix, slice thickness, etc.) are generally employed, various readout bandwidth (BW) values are used as a function of gradients characteristics of the MR scanner. Echo spacing (ES) is another fundamental parameter of EPI-fMRI acquisition sequences but the employed ES value is not usually reported in fMRI studies. In the present work, the authors investigated the effect of ES and BW on basic performances of EPI-fMRI sequences in terms of temporal stability and overall image quality of time series acquisition. EPI-fMRI acquisitions of the same water phantom were performed using two clinical MR scanner systems (scanners A and B) with different gradient characteristics and functional designs of radiofrequency coils. For both scanners, the employed ES values ranged from 0.75 to 1.33 ms. The used BW values ranged from 125.0 to 250.0 kHz/64pixels and from 78.1 to 185.2 kHz/64pixels for scanners A and B, respectively. The temporal stability of EPI-fMRI sequence was assessed measuring the signal-to-fluctuation noise ratio (SFNR) and signal drift (DR), while the overall image quality was assessed evaluating the signal-to-noise ratio (SNR(ts)) and nonuniformity (NU(ts)) of the time series acquisition. For both scanners, no significant effect of ES and BW on signal drift was revealed. The SFNR, NU(ts) and SNR(ts) values of scanner A did not significantly vary with ES. On the other hand, the SFNR, NU(ts), and SNR(ts) values of scanner B significantly varied with ES. SFNR (5.8%) and SNR(ts) (5.9%) increased with increasing ES. SFNR (25% scanner A, 32% scanner B) and SNR(ts) (26.2% scanner A, 30.1% scanner B) values of both scanners significantly decreased with increasing BW. NU(ts) values of scanners A and B were less than 3% for all BW and ES values. Nonetheless, scanner A was characterized by a significant upward trend (3% percentage of variation) of time series nonuniformity with increasing BW while NU(ts) of scanner B significantly increased (19% percentage of variation) with increasing ES. Temporal stability (SFNR and DR) and overall image quality (NU(ts) and SNR(ts)) of EPI-fMRI time series can significantly vary with echo spacing and readout bandwidth. The specific pattern of variation may depend on the performance of each single MR scanner system in terms of gradients characteristics, EPI sequence calibrations (eddy currents, shimming, etc.), and functional design of radiofrequency coil. Our results indicate that the employment of low BW improves not only the signal-to-noise ratio of EPI-fMRI time series but also the temporal stability of functional acquisitions. The use of minimum ES values is not entirely advantageous when the MR scanner system is characterized by gradients with low performances and suboptimal EPI sequence calibration. Since differences in basic performances of MR scanner system are potential source of variability for fMRI activation, phantom measurements of SFNR, DR, NU(ts), and SNR(ts) can be executed before subjects acquisitions to monitor the stability of MR scanner performances in clinical group comparison and longitudinal studies.
2018-01-01
Use of additive manufacturing is growing rapidly in the orthotics field. This technology allows orthotics to be designed directly on digital scans of limbs. However, little information is available about scanners and 3D scans. The aim of this study is to look at the agreement between manual measurements, high-level and low-cost handheld 3D scanners. We took two manual measurements and three 3D scans with each scanner from 14 lower limbs. The lower limbs were divided into 17 sections of 30mm each from 180mm above the mid-patella to 300mm below. Time to record and to process the three 3D scans for scanners methods were compared with Student t-test while Bland-Altman plots were used to study agreement between circumferences of each section from the three methods. The record time was 97s shorter with high-level scanner than with the low-cost (p = .02) while the process time was nine times quicker with the low-cost scanner (p < .01). An overestimation of 2.5mm was found in high-level scanner compared to manual measurement, but with a better repeatability between measurements. The low-cost scanner tended to overestimate the circumferences from 0.1% to 1.5%, overestimation being greater for smaller circumferences. In conclusion, 3D scanners provide more information about the shape of the lower limb, but the reliability depends on the 3D scanner and the size of the scanned segment. Low-cost scanners could be useful for clinicians because of the simple and fast process, but attention should be focused on accuracy, which depends on the scanned body segment. PMID:29320560
Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner.
Kakinuma, Ryutaro; Moriyama, Noriyuki; Muramatsu, Yukio; Gomi, Shiho; Suzuki, Masahiro; Nagasawa, Hirobumi; Kusumoto, Masahiko; Aso, Tomohiko; Muramatsu, Yoshihisa; Tsuchida, Takaaki; Tsuta, Koji; Maeshima, Akiko Miyagi; Tochigi, Naobumi; Watanabe, Shun-Ichi; Sugihara, Naoki; Tsukagoshi, Shinsuke; Saito, Yasuo; Kazama, Masahiro; Ashizawa, Kazuto; Awai, Kazuo; Honda, Osamu; Ishikawa, Hiroyuki; Koizumi, Naoya; Komoto, Daisuke; Moriya, Hiroshi; Oda, Seitaro; Oshiro, Yasuji; Yanagawa, Masahiro; Tomiyama, Noriyuki; Asamura, Hisao
2015-01-01
The image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT) scanners. This study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm x 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm x 16 or 0.5 mm x 64 detector-row CT scanner operating at 150 mAs. Images from both scanners were reconstructed at 0.1-mm intervals; the slice thickness was 0.25 mm for the U-HRCT scanner and 0.5 mm for the C-HRCT scanners. For both scanners, the display field of view was 80 mm. The image noise of each scanner was evaluated using a phantom. U-HRCT and C-HRCT images of 53 images selected from 37 lung nodules were then observed and graded using a 5-point score by 10 board-certified thoracic radiologists. The images were presented to the observers randomly and in a blinded manner. The image noise for U-HRCT (100.87 ± 0.51 Hounsfield units [HU]) was greater than that for C-HRCT (40.41 ± 0.52 HU; P < .0001). The image quality of U-HRCT was graded as superior to that of C-HRCT (P < .0001) for all of the following parameters that were examined: margins of subsolid and solid nodules, edges of solid components and pulmonary vessels in subsolid nodules, air bronchograms, pleural indentations, margins of pulmonary vessels, edges of bronchi, and interlobar fissures. Despite a larger image noise, the prototype U-HRCT scanner had a significantly better image quality than the C-HRCT scanners.
Scanner OPC signatures: automatic vendor-to-vendor OPE matching
NASA Astrophysics Data System (ADS)
Renwick, Stephen P.
2009-03-01
As 193nm lithography continues to be stretched and the k1 factor decreases, optical proximity correction (OPC) has become a vital part of the lithographer's tool kit. Unfortunately, as is now well known, the design variations of lithographic scanners from different vendors cause them to have slightly different optical-proximity effect (OPE) behavior, meaning that they print features through pitch in distinct ways. This in turn means that their response to OPC is not the same, and that an OPC solution designed for a scanner from Company 1 may or may not work properly on a scanner from Company 2. Since OPC is not inexpensive, that causes trouble for chipmakers using more than one brand of scanner. Clearly a scanner-matching procedure is needed to meet this challenge. Previously, automatic matching has only been reported for scanners of different tool generations from the same manufacturer. In contrast, scanners from different companies have been matched using expert tuning and adjustment techniques, frequently requiring laborious test exposures. Automatic matching between scanners from Company 1 and Company 2 has remained an unsettled problem. We have recently solved this problem and introduce a novel method to perform the automatic matching. The success in meeting this challenge required three enabling factors. First, we recognized the strongest drivers of OPE mismatch and are thereby able to reduce the information needed about a tool from another supplier to that information readily available from all modern scanners. Second, we developed a means of reliably identifying the scanners' optical signatures, minimizing dependence on process parameters that can cloud the issue. Third, we carefully employed standard statistical techniques, checking for robustness of the algorithms used and maximizing efficiency. The result is an automatic software system that can predict an OPC matching solution for scanners from different suppliers without requiring expert intervention.
Dessery, Yoann; Pallari, Jari
2018-01-01
Use of additive manufacturing is growing rapidly in the orthotics field. This technology allows orthotics to be designed directly on digital scans of limbs. However, little information is available about scanners and 3D scans. The aim of this study is to look at the agreement between manual measurements, high-level and low-cost handheld 3D scanners. We took two manual measurements and three 3D scans with each scanner from 14 lower limbs. The lower limbs were divided into 17 sections of 30mm each from 180mm above the mid-patella to 300mm below. Time to record and to process the three 3D scans for scanners methods were compared with Student t-test while Bland-Altman plots were used to study agreement between circumferences of each section from the three methods. The record time was 97s shorter with high-level scanner than with the low-cost (p = .02) while the process time was nine times quicker with the low-cost scanner (p < .01). An overestimation of 2.5mm was found in high-level scanner compared to manual measurement, but with a better repeatability between measurements. The low-cost scanner tended to overestimate the circumferences from 0.1% to 1.5%, overestimation being greater for smaller circumferences. In conclusion, 3D scanners provide more information about the shape of the lower limb, but the reliability depends on the 3D scanner and the size of the scanned segment. Low-cost scanners could be useful for clinicians because of the simple and fast process, but attention should be focused on accuracy, which depends on the scanned body segment.
FormScanner: Open-Source Solution for Grading Multiple-Choice Exams
NASA Astrophysics Data System (ADS)
Young, Chadwick; Lo, Glenn; Young, Kaisa; Borsetta, Alberto
2016-01-01
The multiple-choice exam remains a staple for many introductory physics courses. In the past, people have graded these by hand or even flaming needles. Today, one usually grades the exams with a form scanner that utilizes optical mark recognition (OMR). Several companies provide these scanners and particular forms, such as the eponymous "Scantron." OMR scanners combine hardware and software—a scanner and OMR program—to read and grade student-filled forms.
NASA Astrophysics Data System (ADS)
Spangher, A.; Visintini, D.; Tucci, G.; Bonora, V.
2017-05-01
This work has been developed among the researches of a PhD thesis in Civil and Environmental Engineering and Architecture of the University of Udine in cooperation with the GECO Laboratory of the University of Florence. It focuses on the interaction between Geomatics and Structural Analysis, both applied to cultural heritage, and expressly to artefacts and structures in stone materials, like the case study of this paper, the marble statue called "San Giovannino Martelli" (Saint John the Baptist) conserved in Florence. At the beginning, some interesting examples of surveying and structural analyses on statues are reported, in order to remind the complementary tasks and requirements of geomatics and structural analysis. Current laser scanning systems can accurately survey the geometry of a statue or any cultural heritage artefact, essential to understand their structural behaviour and resilience capability. Afterwards, following the few Italian regulations in this field, the possible risks of museum goods are described: topics of this part are more familiar for structural engineers as object classification, seismic reactions, damage mechanisms, possible movements (adherent, slipping and oscillation), dynamic domains, anyway necessary steps to evaluate the risk and so to define eventual interventions. The artistic description of the statue, its debated attribution to Donatello or/and to Desiderio da Settignano and its history is later recalled, remembering that the surveying has been done for the idea to 3D print a replica and to place it in the original place. Having used a close range laser scanner, the obtained 3D model has an impressive geometrical Level of Detail (LoD), whose geometric features are explained in the paper, underlying that such extremely detailed mesh is directly given as output from the laser scanner software. The model simplifications by four decimation are therefore explained and also changes to geometry, like shifts on centre of the mass or barycentre with respect to the original one, are evaluated: since these are pretty null, all the models can be used for structural analysis. Software Scan-and-Solve, a Rhinoceros plug-in, has been employed for Finite Elements Method (FEM) analysis, considering the sole weight and also a horizontal force, as a seismic event or an accidental push, that can synthesize the possible statue risks. The force intensity and geometry have been computed considering the resistance to the overturning for the adherence among statue and pedestal. The more numerically accurate results has been obtained with the more simplified model, having only 7% of initial triangles, since this situation better exploits the computational resources for solver precision and for congruent geometrical LoD and FEM resolution.
Applications of Optical Scanners in an Academic Center.
ERIC Educational Resources Information Center
Molinari, Carol; Tannenbaum, Robert S.
1995-01-01
Describes optical scanners, including how the technology works; applications in data management and research; development of instructional materials; and providing community services. Discussion includes the three basic types of optical scanners: optical character recognition (OCR), optical mark readers (OMR), and graphic scanners. A sidebar…
NASA Technical Reports Server (NTRS)
Biehl, L. L.; Silva, L. F.
1975-01-01
Skylab multispectral scanner data, digitized Skylab color infrared (IR) photography, digitized Skylab black and white multiband photography, and Earth Resources Technology Satellite (ERTS) multispectral scanner data collected within a 24-hr time period over an area in south-central Indiana near Bloomington on June 9 and 10, 1973, were compared in a machine-aided land use analysis of the area. The overall classification performance results, obtained with nine land use classes, were 87% correct classification using the 'best' 4 channels of the Skylab multispectral scanner, 80% for the channels on the Skylab multispectral scanner which are spectrally comparable to the ERTS multispectral scanner, 88% for the ERTS multispectral scanner, 83% for the digitized color IR photography, and 76% for the digitized black and white multiband photography. The results indicate that the Skylab multispectral scanner may yield even higher classification accuracies when a noise-filtered multispectral scanner data set becomes available in the near future.
Impact of survey workflow on precision and accuracy of terrestrial LiDAR datasets
NASA Astrophysics Data System (ADS)
Gold, P. O.; Cowgill, E.; Kreylos, O.
2009-12-01
Ground-based LiDAR (Light Detection and Ranging) survey techniques are enabling remote visualization and quantitative analysis of geologic features at unprecedented levels of detail. For example, digital terrain models computed from LiDAR data have been used to measure displaced landforms along active faults and to quantify fault-surface roughness. But how accurately do terrestrial LiDAR data represent the true ground surface, and in particular, how internally consistent and precise are the mosaiced LiDAR datasets from which surface models are constructed? Addressing this question is essential for designing survey workflows that capture the necessary level of accuracy for a given project while minimizing survey time and equipment, which is essential for effective surveying of remote sites. To address this problem, we seek to define a metric that quantifies how scan registration error changes as a function of survey workflow. Specifically, we are using a Trimble GX3D laser scanner to conduct a series of experimental surveys to quantify how common variables in field workflows impact the precision of scan registration. Primary variables we are testing include 1) use of an independently measured network of control points to locate scanner and target positions, 2) the number of known-point locations used to place the scanner and point clouds in 3-D space, 3) the type of target used to measure distances between the scanner and the known points, and 4) setting up the scanner over a known point as opposed to resectioning of known points. Precision of the registered point cloud is quantified using Trimble Realworks software by automatic calculation of registration errors (errors between locations of the same known points in different scans). Accuracy of the registered cloud (i.e., its ground-truth) will be measured in subsequent experiments. To obtain an independent measure of scan-registration errors and to better visualize the effects of these errors on a registered point cloud, we scan from multiple locations an object of known geometry (a cylinder mounted above a square box). Preliminary results show that even in a controlled experimental scan of an object of known dimensions, there is significant variability in the precision of the registered point cloud. For example, when 3 scans of the central object are registered using 4 known points (maximum time, maximum equipment), the point clouds align to within ~1 cm (normal to the object surface). However, when the same point clouds are registered with only 1 known point (minimum time, minimum equipment), misalignment of the point clouds can range from 2.5 to 5 cm, depending on target type. The greater misalignment of the 3 point clouds when registered with fewer known points stems from the field method employed in acquiring the dataset and demonstrates the impact of field workflow on LiDAR dataset precision. By quantifying the degree of scan mismatch in results such as this, we can provide users with the information needed to maximize efficiency in remote field surveys.
Scanners for analytic print measurement: the devil in the details
NASA Astrophysics Data System (ADS)
Zeise, Eric K.; Williams, Don; Burns, Peter D.; Kress, William C.
2007-01-01
Inexpensive and easy-to-use linear and area-array scanners have frequently substituted as colorimeters and densitometers for low-frequency (i.e., large area) hard copy image measurement. Increasingly, scanners are also being used for high spatial frequency, image microstructure measurements, which were previously reserved for high performance microdensitometers. In this paper we address characteristics of flatbed reflection scanners in the evaluation of print uniformity, geometric distortion, geometric repeatability and the influence of scanner MTF and noise on analytic measurements. Suggestions are made for the specification and evaluation of scanners to be used in print image quality standards that are being developed.
Space-multiplexed optical scanner.
Riza, Nabeel A; Yaqoob, Zahid
2004-05-01
A low-loss two-dimensional optical beam scanner that is capable of delivering large (e.g., > 10 degrees) angular scans along the elevation as well as the azimuthal direction is presented. The proposed scanner is based on a space-switched parallel-serial architecture that employs a coarse-scanner module and a fine-scanner module that produce an ultrahigh scan space-fill factor, e.g., 900 x 900 distinguishable beams in a 10 degrees (elevation) x 10 degrees (azimuth) scan space. The experimentally demonstrated one-dimensional version of the proposed scanner has a supercontinuous scan, 100 distinguishable beam spots in a 2.29 degrees total scan range, and 1.5-dB optical insertion loss.
Thompson, Holly M; Minamimoto, Ryogo; Jamali, Mehran; Barkhodari, Amir; von Eyben, Rie; Iagaru, Andrei
2016-07-01
As quantitative F-FDG PET numbers and pooling of results from different PET/CT scanners become more influential in the management of patients, it becomes imperative that we fully interrogate differences between scanners to fully understand the degree of scanner bias on the statistical power of studies. Participants with body mass index (BMI) greater than 25, scheduled on a time-of-flight (TOF)-capable PET/CT scanner, had a consecutive scan on a non-TOF-capable PET/CT scanner and vice versa. SUVmean in various tissues and SUVmax of malignant lesions were measured from both scans, matched to each subject. Data were analyzed using a mixed-effects model, and statistical significance was determined using equivalence testing, with P < 0.05 being significant. Equivalence was established in all baseline organs, except the cerebellum, matched per patient between scanner types. Mixed-effects method analysis of lesions, repeated between scan types and matched per patient, demonstrated good concordance between scanner types. Patients could be scanned on either a TOF or non-TOF-capable PET/CT scanner without clinical compromise to quantitative SUV measurements.
Technical Note: Development and validation of an open data format for CT projection data.
Chen, Baiyu; Duan, Xinhui; Yu, Zhicong; Leng, Shuai; Yu, Lifeng; McCollough, Cynthia
2015-12-01
Lack of access to projection data from patient CT scans is a major limitation for development and validation of new reconstruction algorithms. To meet this critical need, this work developed and validated a vendor-neutral format for CT projection data, which will further be employed to build a library of patient projection data for public access. A digital imaging and communication in medicine (DICOM)-like format was created for CT projection data (CT-PD), named the DICOM-CT-PD format. The format stores attenuation information in the DICOM image data block and stores parameters necessary for reconstruction in the DICOM header under various tags (51 tags to store the geometry and scan parameters and 9 tags to store patient information). To validate the accuracy and completeness of the new format, CT projection data from helical scans of the ACR CT accreditation phantom were acquired from two clinical CT scanners (Somatom Definition Flash, Siemens Healthcare, Forchheim, Germany and Discovery CT750 HD, GE Healthcare, Waukesha, WI). After decoding (by the authors for Siemens, by the manufacturer for GE), the projection data were converted to the DICOM-CT-PD format. Off-line CT reconstructions were performed by internal and external reconstruction researchers using only the information stored in the DICOM-CT-PD files and the DICOM-CT-PD field definitions. Compared with the commercially reconstructed CT images, the off-line reconstructed images created using the DICOM-CT-PD format are similar in terms of CT numbers (differences of 5 HU for the bone insert and -9 HU for the air insert), image noise (±1 HU), and low contrast detectability (6 mm rods visible in both). Because of different reconstruction approaches, slightly different in-plane and cross-plane high contrast spatial resolution were obtained compared to those reconstructed on the scanners (axial plane: GE off-line, 7 lp/cm; GE commercial, 7 lp/cm; Siemens off-line, 8 lp/cm; Siemens commercial, 7 lp/cm. Coronal plane: Siemens off-line, 6 lp/cm; Siemens commercial, 8 lp/cm). A vendor-neutral extended DICOM format has been developed that enables open sharing of CT projection data from third-generation CT scanners. Validation of the format showed that the geometric parameters and attenuation information in the DICOM-CT-PD file were correctly stored, could be retrieved with use of the provided instructions, and contained sufficient data for reconstruction of CT images that approximated those from the commercial scanner.
21 CFR 892.1300 - Nuclear rectilinear scanner.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Nuclear rectilinear scanner. 892.1300 Section 892...) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1300 Nuclear rectilinear scanner. (a) Identification. A nuclear rectilinear scanner is a device intended to image the distribution of radionuclides in...
21 CFR 892.1300 - Nuclear rectilinear scanner.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Nuclear rectilinear scanner. 892.1300 Section 892...) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1300 Nuclear rectilinear scanner. (a) Identification. A nuclear rectilinear scanner is a device intended to image the distribution of radionuclides in...
Role of ART-27, a Novel Androgen Receptor Coactivator, in Normal Prostate and Prostate Cancer
2005-04-01
associates with pro- teins that include RBP5, a subunit shared by RNA polymerases I, II , and Ill, an RBP5 binding protein called unconventional prefoldin ...of a large multiprotein complex that contains RNA polymerase II subunit 5, a subunit shared by all three RNA polymerases; unconventional prefoldin ...dithiothreitol; GRIP, glucocorticoid re- ceptor Interacting p rotein; HA, hemagglutinin; MMTV, mouse mamm ary tumor virus ; PAIS, partial AIS; SDS
1979-11-01
nic -,L-dant orer unconventional wsr:fare? In shnrt, wfiat were-the pre-1952 roots of tbe’ P9ychrg1.ca1 WArfArPg Contme" artx], cMocom~tant y, the...General Robert A. McClure, 30 March 1948, from Co’.onel William S. Biddle , Assistant Chief, Plans and Policy Group, 1, 319, Plans and Operations Division
Breakdown of Landau Fermi liquid theory: Restrictions on the degrees of freedom of quantum electrons
NASA Astrophysics Data System (ADS)
Su, Yue-Hua; Lu, Han-Tao
2018-04-01
One challenge in contemporary condensed matter physics is to understand unconventional electronic physics beyond the paradigm of Landau Fermi-liquid theory. Here, we present a perspective that posits that most such examples of unconventional electronic physics stem from restrictions on the degrees of freedom of quantum electrons in Landau Fermi liquids. Since the degrees of freedom are deeply connected to the system's symmetries and topology, these restrictions can thus be realized by external constraints or by interaction-driven processes via the following mechanisms: (i) symmetry breaking, (ii) new emergent symmetries, and (iii) nontrivial topology. Various examples of unconventional electronic physics beyond the reach of traditional Landau Fermi liquid theory are extensively investigated from this point of view. Our perspective yields basic pathways to study the breakdown of Landau Fermi liquids and also provides a guiding principle in the search for novel electronic systems and devices.
Unconventional treatments for chronic inflammatory demyelinating polyneuropathy.
Rajabally, Yusuf A
2017-10-01
This article focuses on the unconventional treatments used in chronic inflammatory demyelinating polyneuropathy (CIDP). First line, evidence-based treatments for CIDP include corticosteroids, immunoglobulins and plasma exchanges. Several unproven treatments are however given in treatment-refractory disease or to reduce requirements in validated therapies for reasons of side effects/practical delivery/cost. Despite methodological issues, IFN-α, azathioprine and methotrexate have not been shown to be useful in randomized controlled trials. Cyclophosphamide, rituximab and, as final resort in highly selected cases, hematopoietic stem cell transplant may be options considered in severely disabled refractory patients. Debatably, azathioprine, methotrexate, cyclosporine and mycophenolate mofetil are still occasionally used, among others, in milder disease. Physical therapy may be of benefit in CIDP but is not systematically considered as an integral part of management strategies. Current literature relating to unconventional therapies in CIDP is reviewed here and the possible avenues that require consideration in severe refractory disease and less disabling forms are discussed.
Ota, Yuichi; Okazaki, Kozo; Yamamoto, Haruyoshi Q; Yamamoto, Takashi; Watanabe, Shuntaro; Chen, Chuangtian; Nagao, Masanori; Watauchi, Satoshi; Tanaka, Isao; Takano, Yoshihiko; Shin, Shik
2017-04-21
We investigate the superconducting-gap anisotropy in one of the recently discovered BiS_{2}-based superconductors, NdO_{0.71}F_{0.29}BiS_{2} (T_{c}∼5 K), using laser-based angle-resolved photoemission spectroscopy. Whereas the previously discovered high-T_{c} superconductors such as copper oxides and iron-based superconductors, which are believed to have unconventional superconducting mechanisms, have 3d electrons in their conduction bands, the conduction band of BiS_{2}-based superconductors mainly consists of Bi 6p electrons, and, hence, the conventional superconducting mechanism might be expected. Contrary to this expectation, we observe a strongly anisotropic superconducting gap. This result strongly suggests that the pairing mechanism for NdO_{0.71}F_{0.29}BiS_{2} is an unconventional one and we attribute the observed anisotropy to competitive or cooperative multiple paring interactions.
Superconductivity and Competing Ordered Phase in RuPn (Pn = As, P)
NASA Astrophysics Data System (ADS)
Hirai, Daigorou; Takayama, Tomohiro; Hashizume, Daisuke; Yamamoto, Ayako; Takagi, Hidenori
2011-03-01
Unconventional superconductivity likely manifests itself when some competing electronic phases are suppressed down to zero temperature such as cuprates and iron-pnictide superconductors. Therefore, the correlated metallic state neighboring a competing electronic ordering can be a promising playground for unconventional superconductivity. Here we report superconductivity emerging adjacent to electronically ordered phases of RuPn (Pn = As, P). We found that RuAs(P) exhibits phase transitions at 240 (265) K, which is discerned as a drop of magnetic susceptibility or a resistivity upturn. Such anomalies can be suppressed by substituting Rh to the Ru site. Accompanied by the disappearance of the electronic order, superconductivity was found to emerge below 1.8 K and 3.8 K for RuAs and RuP, respectively. The superconductivity in Rh substituted RuPn, which neighbors a competing electronic order, might exhibit an exotic pairing state as seen in the unconventional superconductors known to date.
Badica, Petre; Crisan, Adrian; Aldica, Gheorghe; Endo, Kazuhiro; Borodianska, Hanna; Togano, Kazumasa; Awaji, Satoshi; Watanabe, Kazuo; Sakka, Yoshio; Vasylkiv, Oleg
2011-02-01
Superconducting materials have contributed significantly to the development of modern materials science and engineering. Specific technological solutions for their synthesis and processing helped in understanding the principles and approaches to the design, fabrication and application of many other materials. In this review, we explore the bidirectional relationship between the general and particular synthesis concepts. The analysis is mostly based on our studies where some unconventional technologies were applied to different superconductors and some other materials. These technologies include spray-frozen freeze-drying, fast pyrolysis, field-assisted sintering (or spark plasma sintering), nanoblasting, processing in high magnetic fields, methods of control of supersaturation and migration during film growth, and mechanical treatments of composite wires. The analysis provides future research directions and some key elements to define the concept of 'beautiful' technology in materials science. It also reconfirms the key position and importance of superconductors in the development of new materials and unconventional synthesis approaches.
H2S and polysulfide metabolism: Conventional and unconventional pathways.
Olson, Kenneth R
2018-03-01
It is now well established that hydrogen sulfide (H 2 S) is an effector of a wide variety of physiological processes. It is also clear that many of the effects of H 2 S are mediated through reactions with cysteine sulfur on regulatory proteins and most of these are not mediated directly by H 2 S but require prior oxidation of H 2 S and the formation of per- and polysulfides (H 2 S n , n = 2-8). Attendant with understanding the regulatory functions of H 2 S and H 2 S n is an appreciation of the mechanisms that control, i.e., both increase and decrease, their production and catabolism. Although a number of standard "conventional" pathways have been described and well characterized, novel "unconventional" pathways are continuously being identified. This review summarizes our current knowledge of both the conventional and unconventional. Copyright © 2017 Elsevier Inc. All rights reserved.
Index theorem for the flat Andreev bound states at a dirty surface of a nodal superconductor
NASA Astrophysics Data System (ADS)
Ikegaya, Satoshi; Asano, Yasuhiro
2018-03-01
We discuss the stability of at-band Andreev bound states appearing at a surface of a nodal unconventional superconductor. In the clean limit, the existence of the surface bound states is topologically characterized by a momentum-dependent topological invariant: one-dimensional winding number de ned in the restricted Brillouin zone. Thus, such topological invariant is ill-defined in the presence of potential disorder which is inevitable in experiments. By paying attention to chiral symmetry of the Hamiltonian, we provide an alternative topological index N ZES that predicts the number of Andreev bound states at a dirty surface of an unconventional superconductor. Moreover, we demonstrate that the zero-bias differential conductance in a normal metal/unconventional superconductor junction is quantized at (4e 2 /h)|N ZES | in the limit of strong impurity scattering in the normal metal.
Unconventional energy resources: 2015 review. Shale gas and liquids
Fishman, Neil S.; Bowker, Kent; Cander, Harris; Cardott, Brian; Charette, Marc; Chew, Kenneth; Chidsey, Thomas; Dubiel, Russell F.; Egenhoff, Sven O.; Enomoto, Catherine B.; Hammes, Ursula; Harrison, William; Jiang, Shu; LeFever, Julie A.; McCracken, Jock; Nordeng, Stephen; Nyahay, Richard; Sonnenberg, Stephen; Vanden Berg, Michael; ,
2015-01-01
Introduction As the source rocks from which petroleum is generated, organic-rich shales have always been considered an important component of petroleum systems. Over the last few years, it has been realized that in some mudrocks, sufficient hydrocarbons remain in place to allow for commercial development, although advanced drilling and completion technology is typically required to access hydrocarbons from these reservoirs. Tight oil reservoirs (also referred to as continuous oil accumulations) contain hydrocarbons migrated from source rocks that are geologically/stratigraphically interbedded with or occur immediately overlying/underlying them. Migration is minimal in charging these tight oil accumulations (Gaswirth and Marra 2014). Companies around the world are now successfully exploiting organic-rich shales and tight rocks for contained hydrocarbons, and the search for these types of unconventional petroleum reservoirs is growing. Unconventional reservoirs range in geologic age from Ordovician to Tertiary (Silverman et al. 2005; EIA 2013a).
Unconventional oil and gas extraction and animal health.
Bamberger, M; Oswald, R E
2014-08-01
The extraction of hydrocarbons from shale formations using horizontal drilling with high volume hydraulic fracturing (unconventional shale gas and tight oil extraction), while derived from methods that have been used for decades, is a relatively new innovation that was introduced first in the United States and has more recently spread worldwide. Although this has led to the availability of new sources of fossil fuels for domestic consumption and export, important issues have been raised concerning the safety of the process relative to public health, animal health, and our food supply. Because of the multiple toxicants used and generated, and because of the complexity of the drilling, hydraulic fracturing, and completion processes including associated infrastructure such as pipelines, compressor stations and processing plants, impacts on the health of humans and animals are difficult to assess definitively. We discuss here findings concerning the safety of unconventional oil and gas extraction from the perspectives of public health, veterinary medicine, and food safety.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chang, Yongjun; Lim, Jonghyuck; Kim, Namkug
2013-05-15
Purpose: To investigate the effect of using different computed tomography (CT) scanners on the accuracy of high-resolution CT (HRCT) images in classifying regional disease patterns in patients with diffuse lung disease, support vector machine (SVM) and Bayesian classifiers were applied to multicenter data. Methods: Two experienced radiologists marked sets of 600 rectangular 20 Multiplication-Sign 20 pixel regions of interest (ROIs) on HRCT images obtained from two scanners (GE and Siemens), including 100 ROIs for each of local patterns of lungs-normal lung and five of regional pulmonary disease patterns (ground-glass opacity, reticular opacity, honeycombing, emphysema, and consolidation). Each ROI was assessedmore » using 22 quantitative features belonging to one of the following descriptors: histogram, gradient, run-length, gray level co-occurrence matrix, low-attenuation area cluster, and top-hat transform. For automatic classification, a Bayesian classifier and a SVM classifier were compared under three different conditions. First, classification accuracies were estimated using data from each scanner. Next, data from the GE and Siemens scanners were used for training and testing, respectively, and vice versa. Finally, all ROI data were integrated regardless of the scanner type and were then trained and tested together. All experiments were performed based on forward feature selection and fivefold cross-validation with 20 repetitions. Results: For each scanner, better classification accuracies were achieved with the SVM classifier than the Bayesian classifier (92% and 82%, respectively, for the GE scanner; and 92% and 86%, respectively, for the Siemens scanner). The classification accuracies were 82%/72% for training with GE data and testing with Siemens data, and 79%/72% for the reverse. The use of training and test data obtained from the HRCT images of different scanners lowered the classification accuracy compared to the use of HRCT images from the same scanner. For integrated ROI data obtained from both scanners, the classification accuracies with the SVM and Bayesian classifiers were 92% and 77%, respectively. The selected features resulting from the classification process differed by scanner, with more features included for the classification of the integrated HRCT data than for the classification of the HRCT data from each scanner. For the integrated data, consisting of HRCT images of both scanners, the classification accuracy based on the SVM was statistically similar to the accuracy of the data obtained from each scanner. However, the classification accuracy of the integrated data using the Bayesian classifier was significantly lower than the classification accuracy of the ROI data of each scanner. Conclusions: The use of an integrated dataset along with a SVM classifier rather than a Bayesian classifier has benefits in terms of the classification accuracy of HRCT images acquired with more than one scanner. This finding is of relevance in studies involving large number of images, as is the case in a multicenter trial with different scanners.« less
Quantitation of clinical feedback on image quality differences between two CT scanner models.
Bache, Steven T; Stauduhar, Paul J; Liu, Xinming; Loyer, Evelyne M; John, Rong X
2017-03-01
The aim of this work was to quantitate differences in image quality between two GE CT scanner models - the LightSpeed VCT ("VCT") and Discovery HD750 ("HD") - based upon feedback from radiologists at our institution. First, 3 yrs of daily QC images of the manufacturer-provided QC phantom from 10 scanners - five of each model - were analyzed for both noise magnitude, measured as CT-number standard deviation, and noise power spectrum within the uniform water section. The same phantom was then scanned on four of each model and analyzed for low contrast detectability (LCD) using a built-in LCD tool at the scanner console. An anthropomorphic phantom was scanned using the same eight scanners. A slice within the abdomen section was chosen and three ROIs were placed in regions representing liver, stomach, and spleen. Both standard deviation of CT-number and LCD value was calculated for each image. Noise magnitude was 8.5% higher in HD scanners compared to VCT scanners. An associated increase in the magnitude of the noise power spectra were also found, but both peak and mean NPS frequency were not different between the two models. VCT scanners outperformed HD scanners with respect to LCD by an average of 13.1% across all scanners and phantoms. Our results agree with radiologist feedback, and necessitate a closer look at our body CT protocols among different scanner models at our institution. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.
21 CFR 882.1925 - Ultrasonic scanner calibration test block.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ultrasonic scanner calibration test block. 882... Ultrasonic scanner calibration test block. (a) Identification. An ultrasonic scanner calibration test block is a block of material with known properties used to calibrate ultrasonic scanning devices (e.g., the...
21 CFR 892.1330 - Nuclear whole body scanner.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Nuclear whole body scanner. 892.1330 Section 892...) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1330 Nuclear whole body scanner. (a) Identification. A nuclear whole body scanner is a device intended to measure and image the distribution of...
21 CFR 892.1330 - Nuclear whole body scanner.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Nuclear whole body scanner. 892.1330 Section 892...) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1330 Nuclear whole body scanner. (a) Identification. A nuclear whole body scanner is a device intended to measure and image the distribution of...
Computed Tomography Scanning and Geophysical Measurements of Core from the Coldstream 1MH Well
DOE Office of Scientific and Technical Information (OSTI.GOV)
Crandall, Dustin M.; Brown, Sarah; Moore, Johnathan E.
The computed tomography (CT) facilities and the Multi-Sensor Core Logger (MSCL) at the National Energy Technology Laboratory (NETL) Morgantown, West Virginia site were used to characterize core of the Marcellus Shale from a vertical well, the Coldstream 1MH Well in Clearfield County, PA. The core is comprised primarily of the Marcellus Shale from a depth of 7,002 to 7,176 ft. The primary impetus of this work is a collaboration between West Virginia University (WVU) and NETL to characterize core from multiple wells to better understand the structure and variation of the Marcellus and Utica shale formations. As part of thismore » effort, bulk scans of core were obtained from the Coldstream 1MH well, provided by the Energy Corporation of America (now Greylock Energy). This report, and the associated scans, provide detailed datasets not typically available from unconventional shales for analysis. The resultant datasets are presented in this report, and can be accessed from NETL's Energy Data eXchange (EDX) online system using the following link: https://edx.netl.doe.gov/dataset/coldstream-1mh-well. All equipment and techniques used were non-destructive, enabling future examinations to be performed on these cores. None of the equipment used was suitable for direct visualization of the shale pore space, although fractures and discontinuities were detectable with the methods tested. Low resolution CT imagery with the NETL medical CT scanner was performed on the entire core. Qualitative analysis of the medical CT images, coupled with x-ray fluorescence (XRF), P-wave, and magnetic susceptibility measurements from the MSCL were useful in identifying zones of interest for more detailed analysis as well as fractured zones. En echelon fractures were observed at 7,100 ft and were CT scanned using NETL’s industrial CT scanner at higher resolution. The ability to quickly identify key areas for more detailed study with higher resolution will save time and resources in future studies. The combination of methods used provided a multi-scale analysis of this core and provides both a macro and micro description of the core that is relevant for many subsurface energy-related examinations that have traditionally been performed at NETL.« less
NASA Astrophysics Data System (ADS)
Rao, A. M.; Moodera, J. S.
1991-04-01
The design of a target scanner that is inexpensive and easy to construct is described. Our target scanner system does not require an expensive personal computer to raster the laser beam uniformily over the target material, unlike the computer driven target scanners that are currently being used in the thin-film industry. The main components of our target scanner comprise a bidirectional motor, a two-position switch, and a standard optical mirror mount.
Side scanner for supermarkets: a new scanner design standard
NASA Astrophysics Data System (ADS)
Cheng, Charles K.; Cheng, J. K.
1996-09-01
High speed UPC bar code has become a standard mode of data capture for supermarkets in the US, Europe, and Japan. The influence of the ergonomics community on the design of the scanner is evident. During the past decade the ergonomic issues of cashier in check-outs has led to occupational hand-wrist cumulative trauma disorders, in most cases causing carpal tunnel syndrome, a permanent hand injury. In this paper, the design of a side scanner to resolve the issues is discussed. The complex optical module and the sensor for aforesaid side scanner is described. The ergonomic advantages offer the old counter mounted vertical scanner has been experimentally proved by the industrial funded study at an independent university.
NASA Astrophysics Data System (ADS)
Mongeon, R. J.
1984-11-01
The beam of a laser radar is moved over the field of view by means of a pair of scanner/trackers arranged in cascade along the laser beam. One of the scanner/trackers operates at high speed, with high resolution and a wide field and is located in the demagnified portion of the laser beam. The two scanner/trackers complement each other to achieve high speed, high resolution scanning as well as tracking of moving targets. A beam steering telescope for an airborne laser radar which incorporates the novel dual mode scanner/tracker is also shown. The other scanner/tracker operates at low speed with low resolution and a wide field and is located in the magnified portion of the laser beam.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Failing, T; Chofor, N; Poppinga, D
Purpose: Investigating the backscatter dose factor with regards to structure and geometry of the surface material. Methods: The titanium cages used for this study representing both prototypes and well established products are made of a laser-sintered titanium alloy (AditusV GmbH, Berlin, Germany). A set of four radiochromic EBT3 films was used in a stacked geometry to measure the range and the magnitude of the expected surface dose enhancement due to the in comparison to water increased secondary electron release from the material. The measurement geometry and the small thickness of radiochromic EBT3 film allowed the dose measurement at distances ofmore » 0.1 mm, 0.9 mm, 1.7 mm and 2.5 mm from the probe surfaces. Water reference measurements were taken under equal conditions, in order to allow the calculation of the relative dose enhancement at the surface of a probe. Measurements were performed within a water phantom. An Epson Expression 10000 XL flatbed scanner was used for digitization. Results: Sintered titanium showed a dose enhancement factor of 1.22 at the surface of the material. The factor can be reduced to less than 1.10 by utilizing mesh structures. In both cases, the dose enhancement factor decreased to less than 1.03 at a distance of 1.7mm indicating the low energy of scattered electrons. Conclusion: Backscattering of titanium cages should be considered in treatment planning, especially when the cages are located close to organs at risk. While mesh structures were introduced to improve bone fusion with the implant structure, the potentially harmful surface dose enhancement is significantly reduced.« less
An empirical model of diagnostic x-ray attenuation under narrow-beam geometry.
Mathieu, Kelsey B; Kappadath, S Cheenu; White, R Allen; Atkinson, E Neely; Cody, Dianna D
2011-08-01
The purpose of this study was to develop and validate a mathematical model to describe narrow-beam attenuation of kilovoltage x-ray beams for the intended applications of half-value layer (HVL) and quarter-value layer (QVL) estimations, patient organ shielding, and computer modeling. An empirical model, which uses the Lambert W function and represents a generalized Lambert-Beer law, was developed. To validate this model, transmission of diagnostic energy x-ray beams was measured over a wide range of attenuator thicknesses [0.49-33.03 mm Al on a computed tomography (CT) scanner, 0.09-1.93 mm Al on two mammography systems, and 0.1-0.45 mm Cu and 0.49-14.87 mm Al using general radiography]. Exposure measurements were acquired under narrow-beam geometry using standard methods, including the appropriate ionization chamber, for each radiographic system. Nonlinear regression was used to find the best-fit curve of the proposed Lambert W model to each measured transmission versus attenuator thickness data set. In addition to validating the Lambert W model, we also assessed the performance of two-point Lambert W interpolation compared to traditional methods for estimating the HVL and QVL [i.e., semi-logarithmic (exponential) and linear interpolation]. The Lambert W model was validated for modeling attenuation versus attenuator thickness with respect to the data collected in this study (R2 > 0.99). Furthermore, Lambert W interpolation was more accurate and less sensitive to the choice of interpolation points used to estimate the HVL and/or QVL than the traditional methods of semilogarithmic and linear interpolation. The proposed Lambert W model accurately describes attenuation of both monoenergetic radiation and (kilovoltage) polyenergetic beams (under narrow-beam geometry).
An empirical model of diagnostic x-ray attenuation under narrow-beam geometry
Mathieu, Kelsey B.; Kappadath, S. Cheenu; White, R. Allen; Atkinson, E. Neely; Cody, Dianna D.
2011-01-01
Purpose: The purpose of this study was to develop and validate a mathematical model to describe narrow-beam attenuation of kilovoltage x-ray beams for the intended applications of half-value layer (HVL) and quarter-value layer (QVL) estimations, patient organ shielding, and computer modeling. Methods: An empirical model, which uses the Lambert W function and represents a generalized Lambert-Beer law, was developed. To validate this model, transmission of diagnostic energy x-ray beams was measured over a wide range of attenuator thicknesses [0.49–33.03 mm Al on a computed tomography (CT) scanner, 0.09–1.93 mm Al on two mammography systems, and 0.1–0.45 mm Cu and 0.49–14.87 mm Al using general radiography]. Exposure measurements were acquired under narrow-beam geometry using standard methods, including the appropriate ionization chamber, for each radiographic system. Nonlinear regression was used to find the best-fit curve of the proposed Lambert W model to each measured transmission versus attenuator thickness data set. In addition to validating the Lambert W model, we also assessed the performance of two-point Lambert W interpolation compared to traditional methods for estimating the HVL and QVL [i.e., semilogarithmic (exponential) and linear interpolation]. Results: The Lambert W model was validated for modeling attenuation versus attenuator thickness with respect to the data collected in this study (R2 > 0.99). Furthermore, Lambert W interpolation was more accurate and less sensitive to the choice of interpolation points used to estimate the HVL and∕or QVL than the traditional methods of semilogarithmic and linear interpolation. Conclusions: The proposed Lambert W model accurately describes attenuation of both monoenergetic radiation and (kilovoltage) polyenergetic beams (under narrow-beam geometry). PMID:21928626
An empirical model of diagnostic x-ray attenuation under narrow-beam geometry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mathieu, Kelsey B.; Kappadath, S. Cheenu; White, R. Allen
2011-08-15
Purpose: The purpose of this study was to develop and validate a mathematical model to describe narrow-beam attenuation of kilovoltage x-ray beams for the intended applications of half-value layer (HVL) and quarter-value layer (QVL) estimations, patient organ shielding, and computer modeling. Methods: An empirical model, which uses the Lambert W function and represents a generalized Lambert-Beer law, was developed. To validate this model, transmission of diagnostic energy x-ray beams was measured over a wide range of attenuator thicknesses [0.49-33.03 mm Al on a computed tomography (CT) scanner, 0.09-1.93 mm Al on two mammography systems, and 0.1-0.45 mm Cu and 0.49-14.87more » mm Al using general radiography]. Exposure measurements were acquired under narrow-beam geometry using standard methods, including the appropriate ionization chamber, for each radiographic system. Nonlinear regression was used to find the best-fit curve of the proposed Lambert W model to each measured transmission versus attenuator thickness data set. In addition to validating the Lambert W model, we also assessed the performance of two-point Lambert W interpolation compared to traditional methods for estimating the HVL and QVL [i.e., semilogarithmic (exponential) and linear interpolation]. Results: The Lambert W model was validated for modeling attenuation versus attenuator thickness with respect to the data collected in this study (R{sup 2} > 0.99). Furthermore, Lambert W interpolation was more accurate and less sensitive to the choice of interpolation points used to estimate the HVL and/or QVL than the traditional methods of semilogarithmic and linear interpolation. Conclusions: The proposed Lambert W model accurately describes attenuation of both monoenergetic radiation and (kilovoltage) polyenergetic beams (under narrow-beam geometry).« less
Inter and intra-system size variability of reverse shoulder arthroplasty polyethylene inserts
Teeter, Matthew G.; Dawson, Matthew T.; Athwal, George S.
2016-01-01
Background: As the incidence of reverse shoulder arthroplasty (RSA) increases, so will the revision burden. At times, the revision surgeon may be faced with a well-fixed component on one side of the joint and revision implants from a different manufacturer. The ability to use glenoid and humeral implants from different manufacturers could simplify the revision procedure. This study hypothesized that across a range of RSA systems, some implants would demonstrate high size compatibility and others would demonstrate low compatibility. Materials and Methods: Six polyethylene inserts each from eight reverse total shoulder arthroplasty systems were examined (48 total inserts). All inserts were scanned using a laboratory micro-computed tomography scanner at 50 μm isotropic voxel spacing, and their surface geometries were reconstructed. The different implant geometries were co-registered, and the three-dimensional (3D) variability between the articular surfaces of the different implant systems was measured. Intrasystem manufacturing variability was also determined by measuring the 3D variability of inserts from the same system. Results: The intersystem polyethylene articular surface deviations between same-size systems were not significantly different (P = 0.61) and were a mean maximum of 60 ± 16 μm (range: 30-80 μm). Intrasystem manufacturing variability was equivalent between all but two models, averaging 49 ± 17 μm (range: 23-99 μm). Discussion: Differences in articular geometry between same-size inserts from different systems were on the same scale as intrasystem manufacturing variability, suggesting that different implant systems of the same nominal diameter could potentially be used interchangeably in revision or extenuating circumstances. Conclusion: The results of this study suggest that surgeons can theoretically interchange same-sized implant components from the different RSA systems tested when conducting revisions. PMID:26980984
Wyatt, Madison; Nave, Gillian
2017-01-01
We evaluated the use of a commercial flatbed scanner for digitizing photographic plates used for spectroscopy. The scanner has a bed size of 420 mm by 310 mm and a pixel size of about 0.0106 mm. Our tests show that the closest line pairs that can be resolved with the scanner are 0.024 mm apart, only slightly larger than the Nyquist resolution of 0.021 mm expected by the 0.0106 mm pixel size. We measured periodic errors in the scanner using both a calibrated length scale and a photographic plate. We find no noticeable periodic errors in the direction parallel to the linear detector in the scanner, but errors with an amplitude of 0.03 mm to 0.05 mm in the direction perpendicular to the detector. We conclude that large periodic errors in measurements of spectroscopic plates using flatbed scanners can be eliminated by scanning the plates with the dispersion direction parallel to the linear detector by placing the plate along the short side of the scanner. PMID:28463262
Laser identification system based on acousto-optical barcode scanner principles
NASA Astrophysics Data System (ADS)
Khansuvarov, Ruslan A.; Korol, Georgy I.; Preslenev, Leonid N.; Bestugin, Aleksandr R.; Paraskun, Arthur S.
2016-09-01
The main purpose of the bar code in the modern world is the unique identification of the product, service, or any of their features, so personal and stationary barcode scanners so widely used. One of the important parameters of bar code scanners is their reliability, accuracy of the barcode recognition, response time and performance. Nowadays, the most popular personal barcode scanners contain a mechanical part, which extremely impairs the reliability indices. Group of SUAI engineers has proposed bar code scanner based on laser beam acoustic deflection effect in crystals [RU patent No 156009 issued 4/16/2015] Through the use of an acousto-optic deflector element in barcode scanner described by a group of engineers SUAI, it can be implemented in the manual form factor, and the stationary form factor of a barcode scanner. Being a wave electronic device, an acousto-optic element in the composition of the acousto-optic barcode scanner allows you to clearly establish a mathematical link between the encoded function of the bar code with the accepted input photodetector intensities function that allows you to speak about the great probability of a bar code clear definition. This paper provides a description of the issued patent, the description of the principles of operation based on the mathematical analysis, a description of the layout of the implemented scanner.
Evaluation of portable CT scanners for otologic image-guided surgery
Balachandran, Ramya; Schurzig, Daniel; Fitzpatrick, J Michael; Labadie, Robert F
2011-01-01
Purpose Portable CT scanners are beneficial for diagnosis in the intensive care unit, emergency room, and operating room. Portable fixed-base versus translating-base CT systems were evaluated for otologic image-guided surgical (IGS) applications based on geometric accuracy and utility for percutaneous cochlear implantation. Methods Five cadaveric skulls were fitted with fiducial markers and scanned using both a translating-base, 8-slice CT scanner (CereTom®) and a fixed-base, flat-panel, volume-CT (fpVCT) scanner (Xoran xCAT®). Images were analyzed for: (a) subjective quality (i.e. noise), (b) consistency of attenuation measurements (Hounsfield units) across similar tissue, and (c) geometric accuracy of fiducial marker positions. The utility of these scanners in clinical IGS cases was tested. Results Five cadaveric specimens were scanned using each of the scanners. The translating-base, 8-slice CT scanner had spatially consistent Hounsfield units, and the image quality was subjectively good. However, because of movement variations during scanning, the geometric accuracy of fiducial marker positions was low. The fixed-base, fpVCT system had high spatial resolution, but the images were noisy and had spatially inconsistent attenuation measurements; while the geometric representation of the fiducial markers was highly accurate. Conclusion Two types of portable CT scanners were evaluated for otologic IGS. The translating-base, 8-slice CT scanner provided better image quality than a fixed-base, fpVCT scanner. However, the inherent error in three-dimensional spatial relationships by the translating-based system makes it suboptimal for otologic IGS use. PMID:21779768
Jafari Roodbandi, Akram Sadat; Naderi, Hamid; Hashenmi-Nejad, Naser; Choobineh, Alireza; Baneshi, Mohammad Reza; Feyzi, Vafa
2017-01-01
Introduction: Three-dimensional (3D) scanners are widely used in medicine. One of the applications of 3D scanners is the acquisition of anthropometric dimensions for ergonomics and the creation of an anthropometry data bank. The aim of this study was to evaluate the precision and accuracy of a modified 3D scanner fabricated in this study. Methods: In this work, a 3D scan of the human body was obtained using DAVID Laser Scanner software and its calibration background, a linear low-power laser, and one advanced webcam. After the 3D scans were imported to the Geomagic software, 10 anthropometric dimensions of 10 subjects were obtained. The measurements of the 3D scanner were compared to the measurements of the same dimensions by a direct anthropometric method. The precision and accuracy of the measurements of the 3D scanner were then evaluated. The obtained data were analyzed using an independent sample t test with the SPSS software. Results: The minimum and maximum measurement differences from three consecutive scans by the 3D scanner were 0.03 mm and 18 mm, respectively. The differences between the measurements by the direct anthropometry method and the 3D scanner were not statistically significant. Therefore, the accuracy of the 3D scanner is acceptable. Conclusion: Future studies will need to focus on the improvement of the scanning speed and the quality of the scanned image.
Jafari Roodbandi, Akram Sadat; Naderi, Hamid; Hashenmi-Nejad, Naser; Choobineh, Alireza; Baneshi, Mohammad Reza; Feyzi, Vafa
2017-01-01
Introduction: Three-dimensional (3D) scanners are widely used in medicine. One of the applications of 3D scanners is the acquisition of anthropometric dimensions for ergonomics and the creation of an anthropometry data bank. The aim of this study was to evaluate the precision and accuracy of a modified 3D scanner fabricated in this study. Methods: In this work, a 3D scan of the human body was obtained using DAVID Laser Scanner software and its calibration background, a linear low-power laser, and one advanced webcam. After the 3D scans were imported to the Geomagic software, 10 anthropometric dimensions of 10 subjects were obtained. The measurements of the 3D scanner were compared to the measurements of the same dimensions by a direct anthropometric method. The precision and accuracy of the measurements of the 3D scanner were then evaluated. The obtained data were analyzed using an independent sample t test with the SPSS software. Results: The minimum and maximum measurement differences from three consecutive scans by the 3D scanner were 0.03 mm and 18 mm, respectively. The differences between the measurements by the direct anthropometry method and the 3D scanner were not statistically significant. Therefore, the accuracy of the 3D scanner is acceptable. Conclusion: Future studies will need to focus on the improvement of the scanning speed and the quality of the scanned image. PMID:28912940
Prostate Cell Specific Regulation of Androgen Receptor Phosphorylation in Vivo
2009-11-01
includes both Rpb5, a subunit shared by RNA polymerase (Pol) I, II , and III, and the corepressor, Unconventional prefoldin Rpb5-Interactor (URI/C19orf2...complex that contains RNA polymerase II subunit 5, a subunit shared by all three RNA polymerases; unconventional prefoldin RPB5-in- teractor (URI), which...sequence of ART-27 is conserved throughout evolution from worms to humans and its predicted protein structure is homologous to the prefoldin -a family of
Ending the Debate: Unconventional Warfare, Foreign Internal Defense, and Why Words Matter
2006-06-01
JCS] apparently was fearful of what it perceived to be the stigma of having the military accused of engaging in subrosa [sic], cloak -and dagger ...was fearful of what it perceived to be the stigma of having the military accused of engaging in sub-rosa, cloak - and- dagger activities in the event of...disrupted by the terrorist attacks of 11 September. Less than two years later, Special Forces had successfully prosecuted two unconventional warfare
,
2015-10-20
From 2000 to 2011, the U.S. Geological Survey conducted 139 quantitative assessments of continuous (unconventional) oil and gas accumulations within the United States. This report documents those assessments more fully than previously done by providing detailed documentation of both the assessment input and output. This report also compiles the data into spreadsheet tables that can be more readily used to provide analogs for future assessments, especially for hypothetical continuous accumulations.
Study of unconventional aircraft engines designed for low energy consumption
NASA Technical Reports Server (NTRS)
Gray, D. E.
1976-01-01
Declining U.S. oil reserves and escalating energy costs underline the need for reducing fuel consumption in aircraft engines. The most promising unconventional aircraft engines based on their potential for fuel savings and improved economics are identified. The engines installed in both a long-range and medium-range aircraft were evaluated. Projected technology advances are identified and evaluated for their state-of-readiness for application to a commercial transport. Programs are recommended for developing the necessary technology.
Bellucci, Michele; De Marchis, Francesca; Pompa, Andrea
2017-12-18
The discovery that much of the extracellular proteome in eukaryotic cells consists of proteins lacking a signal peptide, which cannot therefore enter the secretory pathway, has led to the identification of alternative protein secretion routes bypassing the Golgi apparatus. However, proteins harboring a signal peptide for translocation into the endoplasmic reticulum can also be transported along these alternative routes, which are still far from being well elucidated in terms of the molecular machineries and subcellular/intermediate compartments involved. In this review, we first try to provide a definition of all the unconventional protein secretion pathways in eukaryotic cells, as those pathways followed by proteins directed to an 'external space' bypassing the Golgi, where 'external space' refers to the extracellular space plus the lumen of the secretory route compartments and the inner space of mitochondria and plastids. Then, we discuss the role of the endoplasmic reticulum in sorting proteins toward unconventional traffic pathways in plants. In this regard, various unconventional pathways exporting proteins from the endoplasmic reticulum to the vacuole, plasma membrane, apoplast, mitochondria, and plastids are described, including the short routes followed by the proteins resident in the endoplasmic reticulum. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Unconventional spin distributions in thick Ni{sub 80}Fe{sub 20} nanodisks
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kumar, D.; Lupo, P.; Haldar, A.
2016-05-09
We study the spin distributions in permalloy (Py: Ni{sub 80}Fe{sub 20}) nanodisks as a function of diameter D (300 nm ≤ D ≤ 1 μm) and thickness L (30 nm ≤ L ≤ 100 nm). We observed that beyond a certain thickness, for a fixed disk diameter, an unconventional spin topology precipitates which is marked by the presence of a divergence field within the magnetic vortex curl. The strength of this divergence changes anti-symmetrically from negative to positive—depending on the core polarity—along the axis of the cylindrical nanodisk. This is also accompanied by a skyrmion-like out-of-plane bending of the spin vectors farther away from the disk center. Additionally, the vortex core dilatesmore » significantly when compared to its typical size. This has been directly observed using magnetic force microscopy. We determined from the ferromagnetic resonance spectroscopy measurements that the unconventional topology in the thicker nanodisks gyrated at a frequency, which is significantly lower than what is predicted by a magnetic vortex based analytical model. Micromagnetic simulations involving dipolar and exchange interactions appear to satisfactorily reproduce the experimentally observed static and dynamic behaviors. Besides providing a physical example of an unconventional topology, these results can also aid the design of topologically protected memory elements.« less
Slonecker, Terry E.; Milheim, Lesley E.
2015-01-01
The spatial footprint of unconventional (hydraulic fracturing) and conventional oil and gas development in the Marcellus Shale region of the State of Pennsylvania was digitized from high-resolution, ortho-rectified, digital aerial photography, from 2004 to 2010. We used these data to measure the spatial extent of oil and gas development and to assess the exposure of the extant natural resources across the landscape of the watersheds in the study area. We found that either form of development: (1) occurred in ~50% of the 930 watersheds that defined the study area; (2) was closer to streams than the recommended safe distance in ~50% of the watersheds; (3) was in some places closer to impaired streams and state-defined wildland trout streams than the recommended safe distance; (4) was within 10 upstream kilometers of surface drinking water intakes in ~45% of the watersheds that had surface drinking water intakes; (5) occurred in ~10% of state-defined exceptional value watersheds; (6) occurred in ~30% of the watersheds with resident populations defined as disproportionately exposed to pollutants; (7) tended to occur at interior forest locations; and (8) had >100 residents within 3 km for ~30% of the unconventional oil and gas development sites. Further, we found that exposure to the potential effects of landscape disturbance attributable to conventional oil and gas development was more prevalent than its unconventional counterpart.
Silva, Tânia L S; Morales-Torres, Sergio; Castro-Silva, Sérgio; Figueiredo, José L; Silva, Adrián M T
2017-09-15
Rising global energy demands associated to unbalanced allocation of water resources highlight the importance of water management solutions for the gas industry. Advanced drilling, completion and stimulation techniques for gas extraction, allow more economical access to unconventional gas reserves. This stimulated a shale gas revolution, besides tight gas and coalbed methane, also causing escalating water handling challenges in order to avoid a major impact on the environment. Hydraulic fracturing allied to horizontal drilling is gaining higher relevance in the exploration of unconventional gas reserves, but a large amount of wastewater (known as "produced water") is generated. Its variable chemical composition and flow rates, together with more severe regulations and public concern, have promoted the development of solutions for the treatment and reuse of such produced water. This work intends to provide an overview on the exploration and subsequent environmental implications of unconventional gas sources, as well as the technologies for treatment of produced water, describing the main results and drawbacks, together with some cost estimates. In particular, the growing volumes of produced water from shale gas plays are creating an interesting market opportunity for water technology and service providers. Membrane-based technologies (membrane distillation, forward osmosis, membrane bioreactors and pervaporation) and advanced oxidation processes (ozonation, Fenton, photocatalysis) are claimed to be adequate treatment solutions. Copyright © 2017 Elsevier Ltd. All rights reserved.
Asirdizer, Mahmut; Turkmen, Nursel; Akan, Okan; Yavuz, Mehmet Sunay
2014-06-01
Injury and death cases caused by booby traps are not common in forensic medicine practice. Besides, installation of booby traps including firearms is generally for suicidal and rarely for homicidal purposes. Although few patents were described about home security alarm system that were created by firearms in the United States, 1 sample of injury with a similar unconventional mechanism of home safety system was reported by Asirdizer and Yavuz in 2009. In the published case report, the story of an electrical technician who was invited to a summer house by the homeowner to check the home security alarm system was reported. In the so-called report, he was stated to be injured by the shotgun attached to the unconventional home security alarm system while checking the system. As a result, the homeowner was convicted of a possible intent to cause a life-threatening injury to the technician.The so-called homeowner and his wife died by the same shotgun attached to the same unconventional home security alarm system 4 years on from the first event. In the present case report, we have aimed to present the findings of the crime scene and the autopsies of these unusual 2 deaths and to discuss individual and legal factors in paving the way for the deaths of 2 people.
Method to evaluate the noise of 3D intra-oral scanner.
Desoutter, Alban; Yusuf Solieman, Osama; Subsol, Gérard; Tassery, Hervé; Cuisinier, Frédéric; Fages, Michel
2017-01-01
In dentistry, 3D intra-oral scanners are gaining increasing popularity essentially for the production of dental prostheses. However, there is no normalized procedure to evaluate their basic performance and enable comparisons among intra-oral scanners. The noise value highlights the trueness of a 3D intra-oral scanner and its capacity to plan prosthesis with efficient clinical precision. The aim of the present study is to develop a reproducible methodology for determining the noise of an intra-oral scanner. To this aim, and as a reference, an ultra-flat and ultra-smooth alumina wafer is used as a blank test. The roughness is calculated using an AFM (atomic force microscope) and interferometric microscope measurements to validate this ultra-flat characteristic. Then, two intra-oral scanners (Carestream CS3500 and Trios 3Shape) are used. The wafer is imaged by the two intra-oral scanners with three different angles and two different directions, 10 times for each parameter, given a total of 50 3D-meshes per intra-oral scanner. RMS (root mean square), representing the noise, is evaluated and compared for each angle/direction and each intra-oral scanner, for the whole mesh, and then in a central ROI (region of interest). In this study, we obtained RMS values ranging between 5.29 and 12.58 micrometers. No statistically significant differences were found between the mean RMS of the two intra-oral scanners, but significant differences in angulation and orientations were found between different 3D intra-oral scanners. This study shows that the evaluation of RMS can be an indicator of the value of the noise, which can be easily assessed by applying the present methodology.
Wollenweber, Scott D; Kemp, Brad J
2016-11-01
This investigation aimed to develop a scanner quantification performance methodology and compare multiple metrics between two scanners under different imaging conditions. Most PET scanners are designed to work over a wide dynamic range of patient imaging conditions. Clinical constraints, however, often impact the realization of the entitlement performance for a particular scanner design. Using less injected dose and imaging for a shorter time are often key considerations, all while maintaining "acceptable" image quality and quantitative capability. A dual phantom measurement including resolution inserts was used to measure the effects of in-plane (x, y) and axial (z) system resolution between two PET/CT systems with different block detector crystal dimensions. One of the scanners had significantly thinner slices. Several quantitative measures, including feature contrast recovery, max/min value, and feature profile accuracy were derived from the resulting data and compared between the two scanners and multiple phantoms and alignments. At the clinically relevant count levels used, the scanner with thinner slices had improved performance of approximately 2%, averaged over phantom alignments, measures, and reconstruction methods, for the head-sized phantom, mainly demonstrated with the rods aligned perpendicular to the scanner axis. That same scanner had a slightly decreased performance of -1% for the larger body-size phantom, mostly due to an apparent noise increase in the images. Most of the differences in the metrics between the two scanners were less than 10%. Using the proposed scanner performance methodology, it was shown that smaller detector elements and a larger number of image voxels require higher count density in order to demonstrate improved image quality and quantitation. In a body imaging scenario under typical clinical conditions, the potential advantages of the design must overcome increases in noise due to lower count density.
Quantitative image feature variability amongst CT scanners with a controlled scan protocol
NASA Astrophysics Data System (ADS)
Ger, Rachel B.; Zhou, Shouhao; Chi, Pai-Chun Melinda; Goff, David L.; Zhang, Lifei; Lee, Hannah J.; Fuller, Clifton D.; Howell, Rebecca M.; Li, Heng; Stafford, R. Jason; Court, Laurence E.; Mackin, Dennis S.
2018-02-01
Radiomics studies often analyze patient computed tomography (CT) images acquired from different CT scanners. This may result in differences in imaging parameters, e.g. different manufacturers, different acquisition protocols, etc. However, quantifiable differences in radiomics features can occur based on acquisition parameters. A controlled protocol may allow for minimization of these effects, thus allowing for larger patient cohorts from many different CT scanners. In order to test radiomics feature variability across different CT scanners a radiomics phantom was developed with six different cartridges encased in high density polystyrene. A harmonized protocol was developed to control for tube voltage, tube current, scan type, pitch, CTDIvol, convolution kernel, display field of view, and slice thickness across different manufacturers. The radiomics phantom was imaged on 18 scanners using the control protocol. A linear mixed effects model was created to assess the impact of inter-scanner variability with decomposition of feature variation between scanners and cartridge materials. The inter-scanner variability was compared to the residual variability (the unexplained variability) and to the inter-patient variability using two different patient cohorts. The patient cohorts consisted of 20 non-small cell lung cancer (NSCLC) and 30 head and neck squamous cell carcinoma (HNSCC) patients. The inter-scanner standard deviation was at least half of the residual standard deviation for 36 of 49 quantitative image features. The ratio of inter-scanner to patient coefficient of variation was above 0.2 for 22 and 28 of the 49 features for NSCLC and HNSCC patients, respectively. Inter-scanner variability was a significant factor compared to patient variation in this small study for many of the features. Further analysis with a larger cohort will allow more thorough analysis with additional variables in the model to truly isolate the interscanner difference.
Color accuracy and reproducibility in whole slide imaging scanners
Shrestha, Prarthana; Hulsken, Bas
2014-01-01
Abstract We propose a workflow for color reproduction in whole slide imaging (WSI) scanners, such that the colors in the scanned images match to the actual slide color and the inter-scanner variation is minimum. We describe a new method of preparation and verification of the color phantom slide, consisting of a standard IT8-target transmissive film, which is used in color calibrating and profiling the WSI scanner. We explore several International Color Consortium (ICC) compliant techniques in color calibration/profiling and rendering intents for translating the scanner specific colors to the standard display (sRGB) color space. Based on the quality of the color reproduction in histopathology slides, we propose the matrix-based calibration/profiling and absolute colorimetric rendering approach. The main advantage of the proposed workflow is that it is compliant to the ICC standard, applicable to color management systems in different platforms, and involves no external color measurement devices. We quantify color difference using the CIE-DeltaE2000 metric, where DeltaE values below 1 are considered imperceptible. Our evaluation on 14 phantom slides, manufactured according to the proposed method, shows an average inter-slide color difference below 1 DeltaE. The proposed workflow is implemented and evaluated in 35 WSI scanners developed at Philips, called the Ultra Fast Scanners (UFS). The color accuracy, measured as DeltaE between the scanner reproduced colors and the reference colorimetric values of the phantom patches, is improved on average to 3.5 DeltaE in calibrated scanners from 10 DeltaE in uncalibrated scanners. The average inter-scanner color difference is found to be 1.2 DeltaE. The improvement in color performance upon using the proposed method is apparent with the visual color quality of the tissue scans. PMID:26158041
Quasi-Epipolar Resampling of High Resolution Satellite Stereo Imagery for Semi Global Matching
NASA Astrophysics Data System (ADS)
Tatar, N.; Saadatseresht, M.; Arefi, H.; Hadavand, A.
2015-12-01
Semi-global matching is a well-known stereo matching algorithm in photogrammetric and computer vision society. Epipolar images are supposed as input of this algorithm. Epipolar geometry of linear array scanners is not a straight line as in case of frame camera. Traditional epipolar resampling algorithms demands for rational polynomial coefficients (RPCs), physical sensor model or ground control points. In this paper we propose a new solution for epipolar resampling method which works without the need for these information. In proposed method, automatic feature extraction algorithms are employed to generate corresponding features for registering stereo pairs. Also original images are divided into small tiles. In this way by omitting the need for extra information, the speed of matching algorithm increased and the need for high temporal memory decreased. Our experiments on GeoEye-1 stereo pair captured over Qom city in Iran demonstrates that the epipolar images are generated with sub-pixel accuracy.
Variation of directional reflectance factors with structural changes of a developing alfalfa canopy
NASA Technical Reports Server (NTRS)
Kirchner, J. A.; Kimes, D. S.; Mcmurtrey, J. E., III
1982-01-01
Directional reflectance factors of an alfalfa canopy were determined and related to canopy structure, agronomic variables, and irradiance conditions at four periods during a cutting cycle. Nadir and off-nadir reflectance factors decreased with increasing biomass in Thematic Mapper band 3(0.63-0.69 micrometer) and increased with increasing biomass in band 4(0.76-0.90 micrometer). The sensor view angle had less impact on perceived reflectance as the alfalfa progressed from an erectophile canopy of stems after harvest to a near planophile canopy of leaves at maturity. Studies of directional reflectance are needed for testing and upgrading vegetation canopy models and to aid in the complex interpretation problems presented by aircraft scanners and pointable satellites where illumination and viewing geometries may vary widely. Distinct changes in the patterns of radiance observed by a sensor as structural and biomass changes occur are keys to monitoring the growth and condition of crops.
Reproducibility of geometrical acquisition of intra-thoracic organs of children on CT scans.
Coulongeat, François; Jarrar, Mohamed-Salah; Serre, Thierry; Thollon, Lionel
2011-08-01
This paper analyses geometry of intra-thoracic organs from computed tomography (CT) scans performed on 20 children aged from 4 months to 16 years. A set of two measurements on lungs and heart were performed by the same observer. A third set was performed by a second observer. Thus, the intra- and inter-observer relative deviation of measurements was analysed. Multiple regressions were used in order to study the relationship between the CT properties (scanner, voltage, dose, pixel size, slice increment) and the relative deviation of measurements. There is a very low systematic intra- and inter-observer bias in measurements except for the volume of the heart. None of the CT data properties has a significant influence on the relative deviation of measurement. In the present paper, the measurements and 3D reconstruction protocol described can be applied to characterise the growth of the intra-thoracic organs.
Use of scan overlap redundancy to enhance multispectral aircraft scanner data
NASA Technical Reports Server (NTRS)
Lindenlaub, J. C.; Keat, J.
1973-01-01
Two criteria were suggested for optimizing the resolution error versus signal-to-noise-ratio tradeoff. The first criterion uses equal weighting coefficients and chooses n, the number of lines averaged, so as to make the average resolution error equal to the noise error. The second criterion adjusts both the number and relative sizes of the weighting coefficients so as to minimize the total error (resolution error plus noise error). The optimum set of coefficients depends upon the geometry of the resolution element, the number of redundant scan lines, the scan line increment, and the original signal-to-noise ratio of the channel. Programs were developed to find the optimum number and relative weights of the averaging coefficients. A working definition of signal-to-noise ratio was given and used to try line averaging on a typical set of data. Line averaging was evaluated only with respect to its effect on classification accuracy.
Optical proximity correction for anamorphic extreme ultraviolet lithography
NASA Astrophysics Data System (ADS)
Clifford, Chris; Lam, Michael; Raghunathan, Ananthan; Jiang, Fan; Fenger, Germain; Adam, Kostas
2017-10-01
The change from isomorphic to anamorphic optics in high numerical aperture extreme ultraviolet scanners necessitates changes to the mask data preparation flow. The required changes for each step in the mask tape out process are discussed, with a focus on optical proximity correction (OPC). When necessary, solutions to new problems are demonstrated and verified by rigorous simulation. Additions to the OPC model include accounting for anamorphic effects in the optics, mask electromagnetics, and mask manufacturing. The correction algorithm is updated to include awareness of anamorphic mask geometry for mask rule checking. OPC verification through process window conditions is enhanced to test different wafer scale mask error ranges in the horizontal and vertical directions. This work will show that existing models and methods can be updated to support anamorphic optics without major changes. Also, the larger mask size in the Y direction can result in better model accuracy, easier OPC convergence, and designs that are more tolerant to mask errors.
Principles and Applications of Imaging Radar, Manual of Remote Sensing, 3rd Edition, Volume 2
NASA Astrophysics Data System (ADS)
Moran, M. Susan
Aerial photographs and digital images from orbiting optical scanners are a daily source of information for the general public through newspapers, television, magazines, and posters. Such images are just as prevalent in scientific journal literature. In the last 6 months, more than half of the weekly issues of Eos published an image acquired by a remote digital sensor. As a result, most geoscientists are familiar with the characteristics and even the acronyms of the current satellites and their optical sensors, common detector filters, and image presentation. In many cases, this familiarity has bred contempt. This is so because the limitations of optical sensors (imaging in the visible and infrared portions of the electromagnetic spectrum) can be quite formidable. Images of the surface cannot be acquired through clouds, and image quality is impaired with low-light conditions (such as at polar regions), atmospheric scattering and absorption, and variations in sun/sensor/surface geometry.
D Surveying and Geometric Assessment of a Gothic Nave Vaulting from Point Clouds
NASA Astrophysics Data System (ADS)
Costa-Jover, A.; Ginovart, J. Lluis i.; Coll-Pla, S.; López Piquer, M.; Samper-Sosa, A.; Moreno García, D.; Solís Lorenzo, A. M.
2017-02-01
The development of massive data captures techniques (MDC) in recent years, such as the Terrestrial laser Scanner (TLS), raises the possibility of developing new assessment procedures for architectural heritage. The 3D models that it is able to obtain is a great potential tool, both for conservation purposes and for historical and architectural studies. The paper proposes a simple, non-invasive methodology for the assessment of masonry vaults from point clouds which makes it possible to obtain relevant data about the formal anomalies. The methodology is tested in Tortosa's Gothic Cathedral's vaults, where the geometrical differences between vaults, a priori equal, are identified and related with the partially known construction phases. The procedure can be easily used on any other vaulted construction of any kind, but is especially useful to deal with the complex geometry of Gothic masonry vaults.
System Performance Simulations of the RatCAP Awake Rat Brain Scanner
NASA Astrophysics Data System (ADS)
Shokouhi, S.; Vaska, P.; Schlyer, D. J.; Stoll, S. P.; Villanueva, A.; Kriplani, A.; Woody, C. L.
2005-10-01
The capability to create high quality images from data acquired by the Rat Conscious Animal PET tomograph (RatCAP) has been evaluated using modified versions of the PET Monte Carlo code Simulation System for Emission Tomography (SimSET). The proposed tomograph consists of lutetium oxyorthosilicate (LSO) crystals arranged in 12 4 /spl times/ 8 blocks. The effects of the RatCAPs small ring diameter (/spl sim/40 mm) and its block detector geometry on image quality for small animal studies have been investigated. Since the field of view will be almost as large as the ring diameter, radial elongation artifacts due to parallax error are expected to degrade the spatial resolution and thus the image quality at the edge of the field of view. In addition to Monte Carlo simulations, some preliminary results of experimentally acquired images in both two-dimensional (2-D) and 3-D modes are presented.
Ulker Karbeyaz, Başak; Miller, Eric L; Cleveland, Robin O
2008-05-01
A shaped-based ultrasound tomography method is proposed to reconstruct ellipsoidal objects using a linearized scattering model. The method is motivated by the desire to detect the presence of lesions created by high intensity focused ultrasound (HIFU) in applications of cancer therapy. The computational size and limited view nature of the relevant three-dimensional inverse problem renders impractical the use of traditional pixel-based reconstruction methods. However, by employing a shape-based parametrization it is only necessary to estimate a small number of unknowns describing the geometry of the lesion, in this paper assumed to be ellipsoidal. The details of the shape-based nonlinear inversion method are provided. Results obtained from a commercial ultrasound scanner and a tissue phantom containing a HIFU-like lesion demonstrate the feasibility of the approach where a 20 mm x 5 mm x 6 mm ellipsoidal inclusion was detected with an accuracy of around 5%.
NASA Astrophysics Data System (ADS)
Pack, Robert T.; Saunders, David; Fullmer, Rees; Budge, Scott
2006-05-01
USU LadarSIM Release 2.0 is a ladar simulator that has the ability to feed high-level mission scripts into a processor that automatically generates scan commands during flight simulations. The scan generation depends on specified flight trajectories and scenes consisting of terrain and targets. The scenes and trajectories can either consist of simulated or actual data. The first modeling step produces an outline of scan footprints in xyz space. Once mission goals have been analyzed and it is determined that the scan footprints are appropriately distributed or placed, specific scans can then be chosen for the generation of complete radiometry-based range images and point clouds. The simulation is capable of quickly modeling ray-trace geometry associated with (1) various focal plane arrays and scanner configurations and (2) various scene and trajectories associated with particular maneuvers or missions.
Monte Carlo simulation of Ray-Scan 64 PET system and performance evaluation using GATE toolkit
NASA Astrophysics Data System (ADS)
Li, Suying; Zhang, Qiushi; Vuletic, Ivan; Xie, Zhaoheng; Yang, Kun; Ren, Qiushi
2017-02-01
In this study, we aimed to develop a GATE model for the simulation of Ray-Scan 64 PET scanner and model its performance characteristics. A detailed implementation of system geometry and physical process were included in the simulation model. Then we modeled the performance characteristics of Ray-Scan 64 PET system for the first time, based on National Electrical Manufacturers Association (NEMA) NU-2 2007 protocols and validated the model against experimental measurement, including spatial resolution, sensitivity, counting rates and noise equivalent count rate (NECR). Moreover, an accurate dead time module was investigated to simulate the counting rate performance. Overall results showed reasonable agreement between simulation and experimental data. The validation results showed the reliability and feasibility of the GATE model to evaluate major performance of Ray-Scan 64 PET system. It provided a useful tool for a wide range of research applications.
Ultra-High-Resolution Computed Tomography of the Lung: Image Quality of a Prototype Scanner
Kakinuma, Ryutaro; Moriyama, Noriyuki; Muramatsu, Yukio; Gomi, Shiho; Suzuki, Masahiro; Nagasawa, Hirobumi; Kusumoto, Masahiko; Aso, Tomohiko; Muramatsu, Yoshihisa; Tsuchida, Takaaki; Tsuta, Koji; Maeshima, Akiko Miyagi; Tochigi, Naobumi; Watanabe, Shun-ichi; Sugihara, Naoki; Tsukagoshi, Shinsuke; Saito, Yasuo; Kazama, Masahiro; Ashizawa, Kazuto; Awai, Kazuo; Honda, Osamu; Ishikawa, Hiroyuki; Koizumi, Naoya; Komoto, Daisuke; Moriya, Hiroshi; Oda, Seitaro; Oshiro, Yasuji; Yanagawa, Masahiro; Tomiyama, Noriyuki; Asamura, Hisao
2015-01-01
Purpose The image noise and image quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated and compared with those of conventional high-resolution CT (C-HRCT) scanners. Materials and Methods This study was approved by the institutional review board. A U-HRCT scanner prototype with 0.25 mm x 4 rows and operating at 120 mAs was used. The C-HRCT images were obtained using a 0.5 mm x 16 or 0.5 mm x 64 detector-row CT scanner operating at 150 mAs. Images from both scanners were reconstructed at 0.1-mm intervals; the slice thickness was 0.25 mm for the U-HRCT scanner and 0.5 mm for the C-HRCT scanners. For both scanners, the display field of view was 80 mm. The image noise of each scanner was evaluated using a phantom. U-HRCT and C-HRCT images of 53 images selected from 37 lung nodules were then observed and graded using a 5-point score by 10 board-certified thoracic radiologists. The images were presented to the observers randomly and in a blinded manner. Results The image noise for U-HRCT (100.87 ± 0.51 Hounsfield units [HU]) was greater than that for C-HRCT (40.41 ± 0.52 HU; P < .0001). The image quality of U-HRCT was graded as superior to that of C-HRCT (P < .0001) for all of the following parameters that were examined: margins of subsolid and solid nodules, edges of solid components and pulmonary vessels in subsolid nodules, air bronchograms, pleural indentations, margins of pulmonary vessels, edges of bronchi, and interlobar fissures. Conclusion Despite a larger image noise, the prototype U-HRCT scanner had a significantly better image quality than the C-HRCT scanners. PMID:26352144
Shiga, Tohru; Morimoto, Yuichi; Kubo, Naoki; Katoh, Norio; Katoh, Chietsugu; Takeuchi, Wataru; Usui, Reiko; Hirata, Kenji; Kojima, Shinichi; Umegaki, Kikuo; Shirato, Hiroki; Tamaki, Nagara
2009-01-01
An autoradiography method revealed intratumoral inhomogeneity in various solid tumors. It is becoming increasingly important to estimate intratumoral inhomogeneity. However, with low spatial resolution and high scatter noise, it is difficult to detect intratumoral inhomogeneity in clinical settings. We developed a new PET system with CdTe semiconductor detectors to provide images with high spatial resolution and low scatter noise. Both phantom images and patients' images were analyzed to evaluate intratumoral inhomogeneity. This study was performed with a cold spot phantom that had 6-mm-diameter cold sphenoid defects, a dual-cylinder phantom with an adjusted concentration of 1:2, and an "H"-shaped hot phantom. These were surrounded with water. Phantom images and (18)F-FDG PET images of patients with nasopharyngeal cancer were compared with conventional bismuth germanate PET images. Profile curves for the phantoms were measured as peak-to-valley ratios to define contrast. Intratumoral inhomogeneity and tumor edge sharpness were evaluated on the images of the patients. The contrast obtained with the semiconductor PET scanner (1.53) was 28% higher than that obtained with the conventional scanner (1.20) for the 6-mm-diameter cold sphenoid phantom. The contrast obtained with the semiconductor PET scanner (1.43) was 27% higher than that obtained with the conventional scanner (1.13) for the dual-cylinder phantom. Similarly, the 2-mm cold region between 1-mm hot rods was identified only by the new PET scanner and not by the conventional scanner. The new PET scanner identified intratumoral inhomogeneity in more detail than the conventional scanner in 6 of 10 patients. The tumor edge was sharper on the images obtained with the new PET scanner than on those obtained with the conventional scanner. These phantom and clinical studies suggested that this new PET scanner has the potential for better identification of intratumoral inhomogeneity, probably because of its high spatial resolution and low scatter noise.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ho, Yick Wing, E-mail: mpr@hksh.com; Wong, Wing Kei Rebecca; Yu, Siu Ki
2012-01-01
To evaluate the accuracy in detection of small and low-contrast regions using a high-definition diagnostic computed tomography (CT) scanner compared with a radiotherapy CT simulation scanner. A custom-made phantom with cylindrical holes of diameters ranging from 2-9 mm was filled with 9 different concentrations of contrast solution. The phantom was scanned using a 16-slice multidetector CT simulation scanner (LightSpeed RT16, General Electric Healthcare, Milwaukee, WI) and a 64-slice high-definition diagnostic CT scanner (Discovery CT750 HD, General Electric Healthcare). The low-contrast regions of interest (ROIs) were delineated automatically upon their full width at half maximum of the CT number profile inmore » Hounsfield units on a treatment planning workstation. Two conformal indexes, CI{sub in}, and CI{sub out}, were calculated to represent the percentage errors of underestimation and overestimation in the automated contours compared with their actual sizes. Summarizing the conformal indexes of different sizes and contrast concentration, the means of CI{sub in} and CI{sub out} for the CT simulation scanner were 33.7% and 60.9%, respectively, and 10.5% and 41.5% were found for the diagnostic CT scanner. The mean differences between the 2 scanners' CI{sub in} and CI{sub out} were shown to be significant with p < 0.001. A descending trend of the index values was observed as the ROI size increases for both scanners, which indicates an improved accuracy when the ROI size increases, whereas no observable trend was found in the contouring accuracy with respect to the contrast levels in this study. Images acquired by the diagnostic CT scanner allow higher accuracy on size estimation compared with the CT simulation scanner in this study. We recommend using a diagnostic CT scanner to scan patients with small lesions (<1 cm in diameter) for radiotherapy treatment planning, especially for those pending for stereotactic radiosurgery in which accurate delineation of small-sized, low-contrast regions is important for dose calculation.« less
Out of lab calibration of a rotating 2D scanner for 3D mapping
NASA Astrophysics Data System (ADS)
Koch, Rainer; Böttcher, Lena; Jahrsdörfer, Maximilian; Maier, Johannes; Trommer, Malte; May, Stefan; Nüchter, Andreas
2017-06-01
Mapping is an essential task in mobile robotics. To fulfil advanced navigation and manipulation tasks a 3D representation of the environment is required. Applying stereo cameras or Time-of-flight cameras (TOF cameras) are one way to archive this requirement. Unfortunately, they suffer from drawbacks which makes it difficult to map properly. Therefore, costly 3D laser scanners are applied. An inexpensive way to build a 3D representation is to use a 2D laser scanner and rotate the scan plane around an additional axis. A 3D point cloud acquired with such a custom device consists of multiple 2D line scans. Therefore the scanner pose of each line scan need to be determined as well as parameters resulting from a calibration to generate a 3D point cloud. Using external sensor systems are a common method to determine these calibration parameters. This is costly and difficult when the robot needs to be calibrated outside the lab. Thus, this work presents a calibration method applied on a rotating 2D laser scanner. It uses a hardware setup to identify the required parameters for calibration. This hardware setup is light, small, and easy to transport. Hence, an out of lab calibration is possible. Additional a theoretical model was created to test the algorithm and analyse impact of the scanner accuracy. The hardware components of the 3D scanner system are an HOKUYO UTM-30LX-EW 2D laser scanner, a Dynamixel servo-motor, and a control unit. The calibration system consists of an hemisphere. In the inner of the hemisphere a circular plate is mounted. The algorithm needs to be provided with a dataset of a single rotation from the laser scanner. To achieve a proper calibration result the scanner needs to be located in the middle of the hemisphere. By means of geometric formulas the algorithms determine the individual deviations of the placed laser scanner. In order to minimize errors, the algorithm solves the formulas in an iterative process. First, the calibration algorithm was tested with an ideal hemisphere model created in Matlab. Second, laser scanner was mounted differently, the scanner position and the rotation axis was modified. In doing so, every deviation, was compared with the algorithm results. Several measurement settings were tested repeatedly with the 3D scanner system and the calibration system. The results show that the length accuracy of the laser scanner is most critical. It influences the required size of the hemisphere and the calibration accuracy.
NASA Astrophysics Data System (ADS)
Zechner, A.; Stock, M.; Kellner, D.; Ziegler, I.; Keuschnigg, P.; Huber, P.; Mayer, U.; Sedlmayer, F.; Deutschmann, H.; Steininger, P.
2016-11-01
Image guidance during highly conformal radiotherapy requires accurate geometric calibration of the moving components of the imager. Due to limited manufacturing accuracy and gravity-induced flex, an x-ray imager’s deviation from the nominal geometrical definition has to be corrected for. For this purpose a ball bearing phantom applicable for nine degrees of freedom (9-DOF) calibration of a novel cone-beam computed tomography (CBCT) scanner was designed and validated. In order to ensure accurate automated marker detection, as many uniformly distributed markers as possible should be used with a minimum projected inter-marker distance of 10 mm. Three different marker distributions on the phantom cylinder surface were simulated. First, a fixed number of markers are selected and their coordinates are randomly generated. Second, the quasi-random method is represented by setting a constraint on the marker distances in the projections. The third approach generates the ball coordinates helically based on the Golden ratio, ϕ. Projection images of the phantom incorporating the CBCT scanner’s geometry were simulated and analysed with respect to uniform distribution and intra-marker distance. Based on the evaluations a phantom prototype was manufactured and validated by a series of flexmap calibration measurements and analyses. The simulation with randomly distributed markers as well as the quasi-random approach showed an insufficient uniformity of the distribution over the detector area. The best compromise between uniform distribution and a high packing fraction of balls is provided by the Golden section approach. A prototype was manufactured accordingly. The phantom was validated for 9-DOF geometric calibrations of the CBCT scanner with independently moveable source and detector arms. A novel flexmap calibration phantom intended for 9-DOF was developed. The ball bearing distribution based on the Golden section was found to be highly advantageous. The phantom showed satisfying results for calibrations of the CBCT scanner and provides the basis for further flexmap correction and reconstruction developments.
Fourier rebinning and consistency equations for time-of-flight PET planograms
Li, Yusheng; Defrise, Michel; Matej, Samuel; Metzler, Scott D
2016-01-01
Due to the unique geometry, dual-panel PET scanners have many advantages in dedicated breast imaging and on-board imaging applications since the compact scanners can be combined with other imaging and treatment modalities. The major challenges of dual-panel PET imaging are the limited-angle problem and data truncation, which can cause artifacts due to incomplete data sampling. The time-of-flight (TOF) information can be a promising solution to reduce these artifacts. The TOF planogram is the native data format for dual-panel TOF PET scanners, and the non-TOF planogram is the 3D extension of linogram. The TOF planograms is five-dimensional while the objects are three-dimensional, and there are two degrees of redundancy. In this paper, we derive consistency equations and Fourier-based rebinning algorithms to provide a complete understanding of the rich structure of the fully 3D TOF planograms. We first derive two consistency equations and John's equation for 3D TOF planograms. By taking the Fourier transforms, we obtain two Fourier consistency equations and the Fourier-John equation, which are the duals of the consistency equations and John's equation, respectively. We then solve the Fourier consistency equations and Fourier-John equation using the method of characteristics. The two degrees of entangled redundancy of the 3D TOF data can be explicitly elicited and exploited by the solutions along the characteristic curves. As the special cases of the general solutions, we obtain Fourier rebinning and consistency equations (FORCEs), and thus we obtain a complete scheme to convert among different types of PET planograms: 3D TOF, 3D non-TOF, 2D TOF and 2D non-TOF planograms. The FORCEs can be used as Fourier-based rebinning algorithms for TOF-PET data reduction, inverse rebinnings for designing fast projectors, or consistency conditions for estimating missing data. As a byproduct, we show the two consistency equations are necessary and sufficient for 3D TOF planograms. Finally, we give numerical examples of implementation of a fast 2D TOF planogram projector and Fourier-based rebinning for a 2D TOF planograms using the FORCEs to show the efficacy of the Fourier-based solutions. PMID:28255191
Fourier rebinning and consistency equations for time-of-flight PET planograms.
Li, Yusheng; Defrise, Michel; Matej, Samuel; Metzler, Scott D
2016-01-01
Due to the unique geometry, dual-panel PET scanners have many advantages in dedicated breast imaging and on-board imaging applications since the compact scanners can be combined with other imaging and treatment modalities. The major challenges of dual-panel PET imaging are the limited-angle problem and data truncation, which can cause artifacts due to incomplete data sampling. The time-of-flight (TOF) information can be a promising solution to reduce these artifacts. The TOF planogram is the native data format for dual-panel TOF PET scanners, and the non-TOF planogram is the 3D extension of linogram. The TOF planograms is five-dimensional while the objects are three-dimensional, and there are two degrees of redundancy. In this paper, we derive consistency equations and Fourier-based rebinning algorithms to provide a complete understanding of the rich structure of the fully 3D TOF planograms. We first derive two consistency equations and John's equation for 3D TOF planograms. By taking the Fourier transforms, we obtain two Fourier consistency equations and the Fourier-John equation, which are the duals of the consistency equations and John's equation, respectively. We then solve the Fourier consistency equations and Fourier-John equation using the method of characteristics. The two degrees of entangled redundancy of the 3D TOF data can be explicitly elicited and exploited by the solutions along the characteristic curves. As the special cases of the general solutions, we obtain Fourier rebinning and consistency equations (FORCEs), and thus we obtain a complete scheme to convert among different types of PET planograms: 3D TOF, 3D non-TOF, 2D TOF and 2D non-TOF planograms. The FORCEs can be used as Fourier-based rebinning algorithms for TOF-PET data reduction, inverse rebinnings for designing fast projectors, or consistency conditions for estimating missing data. As a byproduct, we show the two consistency equations are necessary and sufficient for 3D TOF planograms. Finally, we give numerical examples of implementation of a fast 2D TOF planogram projector and Fourier-based rebinning for a 2D TOF planograms using the FORCEs to show the efficacy of the Fourier-based solutions.