undergone sufficient laboratory-scale: Topics by Science.gov

Sample records for undergone sufficient laboratory-scale

Preparation of a Frozen Regolith Simulant Bed for ISRU Component Testing in a Vacuum Chamber

NASA Technical Reports Server (NTRS)

Klenhenz, Julie; Linne, Diane

2013-01-01

In-Situ Resource Utilization (ISRU) systems and components have undergone extensive laboratory and field tests to expose hardware to relevant soil environments. The next step is to combine these soil environments with relevant pressure and temperature conditions. Previous testing has demonstrated how to incorporate large bins of unconsolidated lunar regolith into sufficiently sized vacuum chambers. In order to create appropriate depth dependent soil characteristics that are needed to test drilling operations for the lunar surface, the regolith simulant bed must by properly compacted and frozen. While small cryogenic simulant beds have been created for laboratory tests, this scale effort will allow testing of a full 1m drill which has been developed for a potential lunar prospector mission. Compacted bulk densities were measured at various moisture contents for GRC-3 and Chenobi regolith simulants. Vibrational compaction methods were compared with the previously used hammer compaction, or "Proctor", method. All testing was done per ASTM standard methods. A full 6.13 m3 simulant bed with 6 percent moisture by weight was prepared, compacted in layers, and frozen in a commercial freezer. Temperature and desiccation data was collected to determine logistics for preparation and transport of the simulant bed for thermal vacuum testing. Once in the vacuum facility, the simulant bed will be cryogenically frozen with liquid nitrogen. These cryogenic vacuum tests are underway, but results will not be included in this manuscript.
Crystallization and dissolution of airborne sea-salts on weathered marble in a coastal environment at Delos (Cyclades-Greece)

NASA Astrophysics Data System (ADS)

Chabas, A.; Jeannette, D.; Lefèvre, R. A.

Far from the ground moisture zone, marble remains of Delos archaeological site have undergone an extensive weathering through contour scaling and granular disintegration. Comparison of the analytical results from analytical scanning electron microscopy examination of surface samples of weathered marble and air filtration membranes confirms the atmospheric transport of marine salts and their deposition on stone surface. A laboratory experiment emphasizes the role of these atmospheric salts in the weathering process of marbles in coastal environment.
Validation of mathematical model for CZ process using small-scale laboratory crystal growth furnace

NASA Astrophysics Data System (ADS)

Bergfelds, Kristaps; Sabanskis, Andrejs; Virbulis, Janis

2018-05-01

The present material is focused on the modelling of small-scale laboratory NaCl-RbCl crystal growth furnace. First steps towards fully transient simulations are taken in the form of stationary simulations that deal with the optimization of material properties to match the model to experimental conditions. For this purpose, simulation software primarily used for the modelling of industrial-scale silicon crystal growth process was successfully applied. Finally, transient simulations of the crystal growth are presented, giving a sufficient agreement to experimental results.
Demonstration/Validation of Low Volatile Organic Compound (VOC) Chemical Agent Resistant Coating (CARC)

DTIC Science & Technology

2003-11-25

alkyd resin enamel was 14 Figure 1 -- Test Panels Before Application of WD CARC at MCB Figure 2 -- Test Panels with WD CARC Applied at MCB...WD) Chemical Agent Resistant Coating (CARC) patented (#5,691,410) by the Army Research Laboratory (ARL) has undergone technology Demonstration...Resistant Coating (CARC) patented (#5,691,410) by the Army Research Laboratory (ARL) has undergone technology Demonstration/Validation (Dem/Val) testing
Radiation Effects in Advanced Microelectonic Technologies

NASA Technical Reports Server (NTRS)

Johnston, A. H.

1997-01-01

Several new radiation phenomena have been observed in laboratory testing of advanced microelectonics that are not yet of sufficient importance for typical space applications, but provide insight into the likely effects of scaling and device design on radiation hardness.
Performance of the upgraded ultracold neutron source at Los Alamos National Laboratory and its implication for a possible neutron electric dipole moment experiment

NASA Astrophysics Data System (ADS)

Ito, T. M.; Adamek, E. R.; Callahan, N. B.; Choi, J. H.; Clayton, S. M.; Cude-Woods, C.; Currie, S.; Ding, X.; Fellers, D. E.; Geltenbort, P.; Lamoreaux, S. K.; Liu, C.-Y.; MacDonald, S.; Makela, M.; Morris, C. L.; Pattie, R. W.; Ramsey, J. C.; Salvat, D. J.; Saunders, A.; Sharapov, E. I.; Sjue, S.; Sprow, A. P.; Tang, Z.; Weaver, H. L.; Wei, W.; Young, A. R.

2018-01-01

The ultracold neutron (UCN) source at Los Alamos National Laboratory (LANL), which uses solid deuterium as the UCN converter and is driven by accelerator spallation neutrons, has been successfully operated for over 10 years, providing UCN to various experiments, as the first production UCN source based on the superthermal process. It has recently undergone a major upgrade. This paper describes the design and performance of the upgraded LANL UCN source. Measurements of the cold neutron spectrum and UCN density are presented and compared to Monte Carlo predictions. The source is shown to perform as modeled. The UCN density measured at the exit of the biological shield was 184 (32 ) UCN /cm3 , a fourfold increase from the highest previously reported. The polarized UCN density stored in an external chamber was measured to be 39 (7 ) UCN /cm3 , which is sufficient to perform an experiment to search for the nonzero neutron electric dipole moment with a one-standard-deviation sensitivity of σ (dn) =3 ×10-27e cm .
Potential for improved radiation thermometry measurement uncertainty through implementing a primary scale in an industrial laboratory

NASA Astrophysics Data System (ADS)

Willmott, Jon R.; Lowe, David; Broughton, Mick; White, Ben S.; Machin, Graham

2016-09-01

A primary temperature scale requires realising a unit in terms of its definition. For high temperature radiation thermometry in terms of the International Temperature Scale of 1990 this means extrapolating from the signal measured at the freezing temperature of gold, silver or copper using Planck’s radiation law. The difficulty in doing this means that primary scales above 1000 °C require specialist equipment and careful characterisation in order to achieve the extrapolation with sufficient accuracy. As such, maintenance of the scale at high temperatures is usually only practicable for National Metrology Institutes, and calibration laboratories have to rely on a scale calibrated against transfer standards. At lower temperatures it is practicable for an industrial calibration laboratory to have its own primary temperature scale, which reduces the number of steps between the primary scale and end user. Proposed changes to the SI that will introduce internationally accepted high temperature reference standards might make it practicable to have a primary high temperature scale in a calibration laboratory. In this study such a scale was established by calibrating radiation thermometers directly to high temperature reference standards. The possible reduction in uncertainty to an end user as a result of the reduced calibration chain was evaluated.
A comparison of refuse attenuation in laboratory and field scale lysimeters.

PubMed

Youcai, Zhao; Luochun, Wang; Renhua, Hua; Dimin, Xu; Guowei, Gu

2002-01-01

For this study, small and middle scale laboratory lysimeters, and a large scale field lysimeter in situ in Shanghai Refuse Landfill, with refuse weights of 187,600 and 10,800,000 kg, respectively, were created. These lysimeters are compared in terms of leachate quality (pH, concentrations of COD, BOD and NH3-N), refuse composition (biodegradable matter and volatile solid) and surface settlement for a monitoring period of 0-300 days. The objectives of this study were to explore both the similarities and disparities between laboratory and field scale lysimeters, and to compare degradation behaviors of refuse at the intensive reaction phase in the different scale lysimeters. Quantitative relationships of leachate quality and refuse composition with placement time show that degradation behaviors of refuse seem to depend heavily on the scales of the lysimeters and the parameters of concern, especially in the starting period of 0-6 months. However, some similarities exist between laboratory and field lysimeters after 4-6 months of placement because COD and BOD concentrations in leachate in the field lysimeter decrease regularly in a parallel pattern with those in the laboratory lysimeters. NH3-N, volatile solid (VS) and biodegradable matter (BDM) also gradually decrease in parallel in this intensive reaction phase for all scale lysimeters as refuse ages. Though the concrete data are different among the different scale lysimeters, it may be considered that laboratory lysimeters with sufficient scale are basically applicable for a rough simulation of a real landfill, especially for illustrating the degradation pattern and mechanism. Settlement of refuse surface is roughly proportional to the initial refuse height.
Performance of the upgraded ultracold neutron source at Los Alamos National Laboratory and its implication for a possible neutron electric dipole moment experiment

DOE PAGES

Ito, Takeyasu M.; Adamek, E. R.; Callahan, N. B.; ...

2018-01-29

We report the ultracold neutron (UCN) source at Los Alamos National Laboratory (LANL), which uses solid deuterium as the UCN converter and is driven by accelerator spallation neutrons, has been successfully operated for over 10 years, providing UCN to various experiments, as the first production UCN source based on the superthermal process. It has recently undergone a major upgrade. This paper describes the design and performance of the upgraded LANL UCN source. Measurements of the cold neutron spectrum and UCN density are presented and compared to Monte Carlo predictions. The source is shown to perform as modeled. The UCN densitymore » measured at the exit of the biological shield was 184(32) UCN / cm 3, a fourfold increase from the highest previously reported. Finally, the polarized UCN density stored in an external chamber was measured to be 39(7) UCN / cm 3, which is sufficient to perform an experiment to search for the nonzero neutron electric dipole moment with a one-standard-deviation sensitivity of σ(d n) = 3 × 10 -27 e cm.« less
Performance of the upgraded ultracold neutron source at Los Alamos National Laboratory and its implication for a possible neutron electric dipole moment experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ito, Takeyasu M.; Adamek, E. R.; Callahan, N. B.

We report the ultracold neutron (UCN) source at Los Alamos National Laboratory (LANL), which uses solid deuterium as the UCN converter and is driven by accelerator spallation neutrons, has been successfully operated for over 10 years, providing UCN to various experiments, as the first production UCN source based on the superthermal process. It has recently undergone a major upgrade. This paper describes the design and performance of the upgraded LANL UCN source. Measurements of the cold neutron spectrum and UCN density are presented and compared to Monte Carlo predictions. The source is shown to perform as modeled. The UCN densitymore » measured at the exit of the biological shield was 184(32) UCN / cm 3, a fourfold increase from the highest previously reported. Finally, the polarized UCN density stored in an external chamber was measured to be 39(7) UCN / cm 3, which is sufficient to perform an experiment to search for the nonzero neutron electric dipole moment with a one-standard-deviation sensitivity of σ(d n) = 3 × 10 -27 e cm.« less
Photochemical potential of forest fire smoke

Treesearch

W. Henry Benner; Paul Urone; Charles K. McMahon; Paul Ryan

1977-01-01

A stainless steel laboratory chamber to hold the entire combustion products from a small scale pine needle fire was useful for measuring the photochemical activity of pine needle fire smoke. Particle size distributions indicated that the nucleation of small numbers of submicron particles was sufficient to increase the amount of light a plume would scatter. Artificial...
Magnetic resonance imaging in laboratory petrophysical core analysis

NASA Astrophysics Data System (ADS)

Mitchell, J.; Chandrasekera, T. C.; Holland, D. J.; Gladden, L. F.; Fordham, E. J.

2013-05-01

Magnetic resonance imaging (MRI) is a well-known technique in medical diagnosis and materials science. In the more specialized arena of laboratory-scale petrophysical rock core analysis, the role of MRI has undergone a substantial change in focus over the last three decades. Initially, alongside the continual drive to exploit higher magnetic field strengths in MRI applications for medicine and chemistry, the same trend was followed in core analysis. However, the spatial resolution achievable in heterogeneous porous media is inherently limited due to the magnetic susceptibility contrast between solid and fluid. As a result, imaging resolution at the length-scale of typical pore diameters is not practical and so MRI of core-plugs has often been viewed as an inappropriate use of expensive magnetic resonance facilities. Recently, there has been a paradigm shift in the use of MRI in laboratory-scale core analysis. The focus is now on acquiring data in the laboratory that are directly comparable to data obtained from magnetic resonance well-logging tools (i.e., a common physics of measurement). To maintain consistency with well-logging instrumentation, it is desirable to measure distributions of transverse (T2) relaxation time-the industry-standard metric in well-logging-at the laboratory-scale. These T2 distributions can be spatially resolved over the length of a core-plug. The use of low-field magnets in the laboratory environment is optimal for core analysis not only because the magnetic field strength is closer to that of well-logging tools, but also because the magnetic susceptibility contrast is minimized, allowing the acquisition of quantitative image voxel (or pixel) intensities that are directly scalable to liquid volume. Beyond simple determination of macroscopic rock heterogeneity, it is possible to utilize the spatial resolution for monitoring forced displacement of oil by water or chemical agents, determining capillary pressure curves, and estimating wettability. The history of MRI in petrophysics is reviewed and future directions considered, including advanced data processing techniques such as compressed sensing reconstruction and Bayesian inference analysis of under-sampled data. Although this review focuses on rock core analysis, the techniques described are applicable in a wider context to porous media in general, such as cements, soils, ceramics, and catalytic materials.
[AT THE CROSSROADS: THE ROLE OF LABORATORY MEDICINE IN THE PATIENT CARE PROCESS].

PubMed

Geffen, Yuval; Zaidise, Itzhak

2017-06-01

In recent decades, the laboratory medicine profession has undergone significant changes due to both technological developments and economic constraints. Technological innovations support automation, provide faster and more accurate equipment, and allow increased efficiency through the use of commercial test kits. These changes, combined with budgetary constraints, have led to mergers and centralization of medical laboratories to optimize work and cut costs. While this centralization may be a business necessity, it leads to a disconnection between the laboratory and the clinical context. In addition, laboratory tests are treated as a commodity, which places emphasis on price only, rather than quality. In this article, we review the developments and changes that medical laboratories and the laboratory medicine profession have undergone in recent decades. We focus on technological and structural challenges affecting the functioning of medical laboratories and the relations between laboratory workers and medical teams. We then introduce vocational education changes required for the laboratory medicine profession. We propose defining the role of medical laboratory directors in terms of their basic training as medical doctors or doctors of science. We suggest that laboratory employees should become a reliable source of information regarding selection of appropriate test methods, processing data and presenting the results to the medical staff. Laboratory workers must deepen their clinical knowledge and become an integral part of the patient care process, along with medical and nursing staff. Special training programs for medical laboratory workers and directors must be developed in order to match the complex activities currently being conducted in laboratories.
The Spanish version of the Fatigue Assessment Scale: reliability and validity assessment in postpartum women

PubMed Central

Cano-Climent, Antoni; de Vries, Jolanda

2017-01-01

Background Fatigue is the most widely reported symptom by women during pregnancy, labour, the postpartum period, and early parenting. The objective was to translate the Fatigue Assessment Scale (FAS) into Spanish and assess its psychometric properties. Methods Instrumental Design. The FAS was translated into Spanish (FAS-e) using forward and back translation. A convenience sample was constituted with 870 postpartum women recruited at discharge from 17 public hospitals in Eastern Spain. Data was obtained from clinical records and self-administered questionnaires at discharge. Internal consistency, factor structure, comparisons between known groups and correlations with other variables were assessed. Results Cronbach’s alpha coefficient was .80. Findings on the dimensionality of the FAS-e scale indicated that it was sufficiently unidimensional. FAS-e scores were higher among women who had undergone caesarean births (p < .05), had a higher level of postpartum pain (p < .01), experienced difficulties during breastfeeding (p < .01) and had lower levels of self-efficacy for breastfeeding (p < .01). Conclusions An equivalent Spanish version of the FAS was obtained with good reliability and validity properties. FAS-e is an appropriate tool to measure postpartum fatigue. PMID:28970968
2016 Offshore Wind Energy Resource Assessment for the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Musial, Walt; Heimiller, Donna; Beiter, Philipp

2016-09-01

This report, the 2016 Offshore Wind Energy Resource Assessment for the United States, was developed by the National Renewable Energy Laboratory, and updates a previous national resource assessment study, and refines and reaffirms that the available wind resource is sufficient for offshore wind to be a large-scale contributor to the nation's electric energy supply.
Laboratory for Atmospheres: 2004 Technical Highlights

NASA Technical Reports Server (NTRS)

2005-01-01

The report describes our role in NASA's mission, gives a broad description of our research, and summarizes our scientists' major accomplishments in 2004. The report also contains useful information on human resources, scientific interactions, outreach activities, and the transformation our laboratory has undergone. This report is published in two versions: 1) an abbreviated print version, and 2) an unabridged electronic version at our Laboratory for Atmospheres Web site: http://atmospheres.gsfc.nasa.gov/.
Stigma in mental illness: attitudes of medical students towards mental illness.

PubMed

Mas, A; Hatim, A

2002-12-01

Negative attitudes towards people with mental illness can be attributed to stigma. The objective of this study was to determine the attitudes of medical students towards mental illness by comparing those who have had contact with mental patients and those who have not. This study also assesses to what extent knowledge about mental illness can affect the students' attitude. A vignette and two dependent measures (social distance scale and dangerousness scale) were used to assess the attitudes of medical students towards mental illness. They comprised of 108 first year and 85 final year medical students in University of Malaya, Kuala Lumpur. The first year students didn't have any prior psychiatric training. The final year students who had knowledge and contact (undergone 8 weeks of clinical psychiatric training) were less stigmatizing toward mentally ill patients. There were no significant differences in the attitudes towards mentally ill patient among the first year students (no knowledge) regardless they had previous contact or not. Knowledge seems to have the effect in inculcating greater tolerance of mental illness. Contact by itself is not sufficient for attitude changes.
EARLY-TYPE GALAXIES WITH TIDAL DEBRIS AND THEIR SCALING RELATIONS IN THE SPITZER SURVEY OF STELLAR STRUCTURE IN GALAXIES (S{sup 4}G)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Taehyun; Sheth, Kartik; Munoz-Mateos, Juan-Carlos

2012-07-01

Tidal debris around galaxies can yield important clues on their evolution. We have identified tidal debris in 11 early-type galaxies (T {<=} 0) from a sample of 65 early types drawn from the Spitzer Survey of Stellar Structure in Galaxies (S{sup 4}G). The tidal debris includes features such as shells, ripples, and tidal tails. A variety of techniques, including two-dimensional decomposition of galactic structures, were used to quantify the residual tidal features. The tidal debris contributes {approx}3%-10% to the total 3.6 {mu}m luminosity of the host galaxy. Structural parameters of the galaxies were estimated using two-dimensional profile fitting. We investigatemore » the locations of galaxies with tidal debris in the fundamental plane and Kormendy relation. We find that galaxies with tidal debris lie within the scatter of early-type galaxies without tidal features. Assuming that the tidal debris is indicative of recent gravitational interaction or merger, this suggests that these galaxies have either undergone minor merging events so that the overall structural properties of the galaxies are not significantly altered, or they have undergone a major merging events but already have experienced sufficient relaxation and phase mixing so that their structural properties become similar to those of the non-interacting early-type galaxies.« less
Endoscopic retrograde cholangiopancreatography-associated AmpC Escherichia coli outbreak.

PubMed

Wendorf, Kristen A; Kay, Meagan; Baliga, Christopher; Weissman, Scott J; Gluck, Michael; Verma, Punam; D'Angeli, Marisa; Swoveland, Jennifer; Kang, Mi-Gyeong; Eckmann, Kaye; Ross, Andrew S; Duchin, Jeffrey

2015-06-01

We identified an outbreak of AmpC-producing Escherichia coli infections resistant to third-generation cephalosporins and carbapenems (CR) among 7 patients who had undergone endoscopic retrograde cholangiopancreatography at hospital A during November 2012-August 2013. Gene sequencing revealed a shared novel mutation in a bla CMY gene and a distinctive fumC/ fimH typing profile. To determine the extent and epidemiologic characteristics of the outbreak, identify potential sources of transmission, design and implement infection control measures, and determine the association between the CR E. coli and AmpC E. coli circulating at hospital A. We reviewed laboratory, medical, and endoscopy reports, and endoscope reprocessing procedures. We obtained cultures from endoscopes after reprocessing as well as environmental samples and conducted pulsed-field gel electrophoresis and gene sequencing on phenotypic AmpC isolates from patients and endoscopes. Cases were those infected with phenotypic AmpC isolates (both carbapenem-susceptible and CR) and identical bla CMY-2, fumC, and fimH alleles or related pulsed-field gel electrophoresis patterns. Thirty-five of 49 AmpC E. coli tested met the case definition, including all CR isolates. All cases had complicated biliary disease and had undergone at least 1 endoscopic retrograde cholangiopancreatography at hospital A. Mortality at 30 days was 16% for all patients and 56% for CR patients. Two of 8 reprocessed endoscopic retrograde cholangiopancreatography scopes harbored AmpC that matched case isolates by pulsed-field gel electrophoresis. Environmental cultures were negative. No breaches in infection control were identified. Endoscopic reprocessing exceeded manufacturer's recommended cleaning guidelines. Recommended reprocessing guidelines are not sufficient.
Test Plan for the Wake Steering Experiment at the Scaled Wind Farm Technology (SWiFT) Facility.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naughton, Brian Thomas

This document is a test plan describing the objectives, configuration, procedures, reporting, roles, and responsibilities for conducting the joint Sandia National Laboratories and National Renewable Energy Laboratory Wake Steering Experiment at the Sandia Scaled Wind Farm Technology (SWiFT) facility near Lubbock, Texas in 2016 and 2017 . The purpose of this document is to ensure the test objectives and procedures are sufficiently detailed such that al l involved personnel are able to contribute to the technical success of the test. This document is not intended to address safety explicitly which is addressed in a separate document listed in the referencesmore » titled Sandia SWiFT Facility Site Operations Manual . Both documents should be reviewed by all test personnel.« less

Riparian rehabilitation using vegetation patches: field and laboratory investigations linking hydrology, vegetation and geomorphology

NASA Astrophysics Data System (ADS)

Rodriguez, J. F.; Gorrick, S.

2010-12-01

We present results of a riparian revegetation project on an oversized sand stream in eastern Australia. The Widden Brook in New South Wales has undergone extensive widening due to extraordinary floods in the 1950’s and is currently showing some signs of recovery. These include emergence of pool-riffle structure and stabilization of stream width, which are the result of upstream sediment control, riparian revegetation and livestock exclusion. Revegetation of a mild bend was carried out in 2004 using native plants in an arrangement that consisted of three vegetation patches. The same arrangement was tested in a reduced scale model in the laboratory, where extensive measurements of flow, sediment and bed changes provided insight into the links between hydrology, vegetation and geomorphology. Laboratory tests also included runs without vegetation and with a continuous vegetation cover. In terms of bank stability, the patches provided as much protection as the continuous vegetation. Based on the experiments, a series of analytical relationships were developed to help guide the design of vegetation patches focusing on the geomorphic stability of the whole reach instead of concentrating only on the near bank effects.
Seismic evidence for widespread western-US deep-crustal deformation caused by extension

USGS Publications Warehouse

Moschetti, M.P.; Ritzwoller, M.H.; Lin, F.; Yang, Y.

2010-01-01

Laboratory experiments have established that many of the materials comprising the Earth are strongly anisotropic in terms of seismic-wave speeds. Observations of azimuthal and radial anisotropy in the upper mantle are attributed to the lattice-preferred orientation of olivine caused by the shear strains associated with deformation, and provide some of the most direct evidence for deformation and flow within the Earths interior. Although observations of crustal radial anisotropy would improve our understanding of crustal deformation and flow patterns resulting from tectonic processes, large-scale observations have been limited to regions of particularly thick crust. Here we show that observations from ambient noise tomography in the western United States reveal strong deep (middle to lower)-crustal radial anisotropy that is confined mainly to the geological provinces that have undergone significant extension during the Cenozoic Era (since 65 Myr ago). The coincidence of crustal radial anisotropy with the extensional provinces of the western United States suggests that the radial anisotropy results from the lattice-preferred orientation of anisotropic crustal minerals caused by extensional deformation. These observations also provide support for the hypothesis that the deep crust within these regions has undergone widespread and relatively uniform strain in response to crustal thinning and extension. ?? 2010 Macmillan Publishers Limited. All rights reserved.
Cross-flow turbines: progress report on physical and numerical model studies at large laboratory scale

NASA Astrophysics Data System (ADS)

Wosnik, Martin; Bachant, Peter

2016-11-01

Cross-flow turbines show potential in marine hydrokinetic (MHK) applications. A research focus is on accurately predicting device performance and wake evolution to improve turbine array layouts for maximizing overall power output, i.e., minimizing wake interference, or taking advantage of constructive wake interaction. Experiments were carried with large laboratory-scale cross-flow turbines D O (1 m) using a turbine test bed in a large cross-section tow tank, designed to achieve sufficiently high Reynolds numbers for the results to be Reynolds number independent with respect to turbine performance and wake statistics, such that they can be reliably extrapolated to full scale and used for model validation. Several turbines of varying solidity were employed, including the UNH Reference Vertical Axis Turbine (RVAT) and a 1:6 scale model of the DOE-Sandia Reference Model 2 (RM2) turbine. To improve parameterization in array simulations, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier-Stokes models. Results are presented for the simulation of performance and wake dynamics of cross-flow turbines and compared with experiments and body-fitted mesh, blade-resolving CFD. Supported by NSF-CBET Grant 1150797, Sandia National Laboratories.
Determining binder flushing causes in New York state.

DOT National Transportation Integrated Search

2014-12-01

In 2007, a number of asphalt pavements in New York State flushed. An extensive forensic and laboratory : investigation was conducted to determine why particular New York State asphalt pavements constructed in 2007 had : undergone atypical flush...
3D chemical imaging in the laboratory by hyperspectral X-ray computed tomography

PubMed Central

Egan, C. K.; Jacques, S. D. M.; Wilson, M. D.; Veale, M. C.; Seller, P.; Beale, A. M.; Pattrick, R. A. D.; Withers, P. J.; Cernik, R. J.

2015-01-01

We report the development of laboratory based hyperspectral X-ray computed tomography which allows the internal elemental chemistry of an object to be reconstructed and visualised in three dimensions. The method employs a spectroscopic X-ray imaging detector with sufficient energy resolution to distinguish individual elemental absorption edges. Elemental distributions can then be made by K-edge subtraction, or alternatively by voxel-wise spectral fitting to give relative atomic concentrations. We demonstrate its application to two material systems: studying the distribution of catalyst material on porous substrates for industrial scale chemical processing; and mapping of minerals and inclusion phases inside a mineralised ore sample. The method makes use of a standard laboratory X-ray source with measurement times similar to that required for conventional computed tomography. PMID:26514938
Hair transplantation in patients with inadequate head donor supply using nonhead hair: report of 3 cases.

PubMed

Umar, Sanusi

2011-10-01

Follicular unit extraction is becoming an increasingly popular technique for hair transplantation, as it obviates the linear scarring associated with strip harvesting, and can provide highly presentable results. Using this technique, a few reports have described the small scale use of nonhead hair for head hair transplantation in men with inadequate head hair donor supply. In this report, 3 patients who were severely bald had hair transplanted from the chest, abdomen, legs, shoulders, or beard, as well as the head to achieve full coverage and excellent hairlines. Of the 3 cases, 2 had undergone previously unsuccessful hair transplant surgeries. Approximately 80% to 85% of the transplanted grafts survived. Although hair length and quality, surgery time, and the requirement for improved surgical skills remain challenges when using this technique, the sufficiently good outcomes from these selected candidates suggest that this technique may offer the possibility of restoring even severely bald states to normality in patients who would otherwise not be candidates for traditional hair transplantation surgery.
An apparatus for in situ x-ray scattering measurements during polymer injection molding.

PubMed

Rendon, Stanley; Fang, Jun; Burghardt, Wesley R; Bubeck, Robert A

2009-04-01

We report a novel instrument for synchrotron-based in situ x-ray scattering measurements during injection molding processing. It allows direct, real-time monitoring of molecular-scale structural evolution in polymer materials undergoing a complex processing operation. The instrument is based on a laboratory-scale injection molding machine, and employs customized mold tools designed to allow x-ray access during mold filling and subsequent solidification, while providing sufficient robustness to withstand high injection pressures. The use of high energy, high flux synchrotron radiation, and a fast detector allows sufficiently rapid data acquisition to resolve time-dependent orientation dynamics in this transient process. Simultaneous monitoring of temperature and pressure signals allows transient scattering data to be referenced to various stages of the injection molding cycle. Representative data on a commercial liquid crystalline polymer, Vectra(R) B950, are presented to demonstrate the features of this apparatus; however, it may find application in a wide range of polymeric materials such as nanocomposites, semicrystalline polymers and fiber-reinforced thermoplastics.
Same Constructs, Different Results: Examining the Consistency of Two Behavior-Rating Scales with Referred Preschoolers

ERIC Educational Resources Information Center

Myers, Carl L.; Bour, Jennifer L.; Sidebottom, Kristina J.; Murphy, Sara B.; Hakman, Melissa

2010-01-01

Broad-band or multidimensional behavior-rating scales are common tools for evaluating children. Two popular behavior-rating scales, the Behavior Assessment System for Children, Second Edition (BASC-2; Reynolds & Kamphaus, 2004) and the Child Behavior Checklist (CBCL; Achenbach & Rescorla, 2000), have undergone downward extensions so that…
Intraoperative Computed Tomography for Cervicomedullary Decompression of Foramen Magnum Stenosis in Achondroplasia: Two Case Reports

PubMed Central

Arishima, Hidetaka; Tsunetoshi, Kenzo; Kodera, Toshiaki; Kitai, Ryuhei; Takeuchi, Hiroaki; Kikuta, Ken-ichiro

2013-01-01

The authors report two cases of cervicomedullary decompression of foramen magnum (FM) stenosis in children with achondroplasia using intraoperative computed tomography (iCT). A 14-month-old girl with myelopathy and retarded motor development, and a 10-year-old girl who had already undergone incomplete FM decompression was presented with myelopathy. Both patients underwent decompressive sub-occipitalcraniectomy and C1 laminectomy without duraplasty using iCT. It clearly showed the extent of FM decompression during surgery, which finally enabled sufficient decompression. After the operation, their myelopathy improved. We think that iCT can provide useful information and guidance for sufficient decompression for FM stenosis in children with achondroplasia. PMID:24140778
Intraoperative computed tomography for cervicomedullary decompression of foramen magnum stenosis in achondroplasia: two case reports.

PubMed

Arishima, Hidetaka; Tsunetoshi, Kenzo; Kodera, Toshiaki; Kitai, Ryuhei; Takeuchi, Hiroaki; Kikuta, Ken-Ichiro

2013-01-01

The authors report two cases of cervicomedullary decompression of foramen magnum (FM) stenosis in children with achondroplasia using intraoperative computed tomography (iCT). A 14-month-old girl with myelopathy and retarded motor development, and a 10-year-old girl who had already undergone incomplete FM decompression was presented with myelopathy. Both patients underwent decompressive sub-occipitalcraniectomy and C1 laminectomy without duraplasty using iCT. It clearly showed the extent of FM decompression during surgery, which finally enabled sufficient decompression. After the operation, their myelopathy improved. We think that iCT can provide useful information and guidance for sufficient decompression for FM stenosis in children with achondroplasia.
Advances in Structural Integrity Analysis Methods for Aging Metallic Airframe Structures with Local Damage

NASA Technical Reports Server (NTRS)

Starnes, James H., Jr.; Newman, James C., Jr.; Harris, Charles E.; Piascik, Robert S.; Young, Richard D.; Rose, Cheryl A.

2003-01-01

Analysis methodologies for predicting fatigue-crack growth from rivet holes in panels subjected to cyclic loads and for predicting the residual strength of aluminum fuselage structures with cracks and subjected to combined internal pressure and mechanical loads are described. The fatigue-crack growth analysis methodology is based on small-crack theory and a plasticity induced crack-closure model, and the effect of a corrosive environment on crack-growth rate is included. The residual strength analysis methodology is based on the critical crack-tip-opening-angle fracture criterion that characterizes the fracture behavior of a material of interest, and a geometric and material nonlinear finite element shell analysis code that performs the structural analysis of the fuselage structure of interest. The methodologies have been verified experimentally for structures ranging from laboratory coupons to full-scale structural components. Analytical and experimental results based on these methodologies are described and compared for laboratory coupons and flat panels, small-scale pressurized shells, and full-scale curved stiffened panels. The residual strength analysis methodology is sufficiently general to include the effects of multiple-site damage on structural behavior.
Nuclear Science References (NSR)

Science.gov Websites

be included. For more information, see the help page. The NSR database schema and Web applications have undergone some recent changes. This is a revised version of the NSR Web Interface. NSR Quick Manager: Boris Pritychenko, NNDC, Brookhaven National Laboratory Web Programming: Boris Pritychenko, NNDC
A laser-based ice shape profilometer for use in icing wind tunnels

NASA Technical Reports Server (NTRS)

Hovenac, Edward A.; Vargas, Mario

1995-01-01

A laser-based profilometer was developed to measure the thickness and shape of ice accretions on the leading edge of airfoils and other models in icing wind tunnels. The instrument is a hand held device that is connected to a desk top computer with a 10 meter cable. It projects a laser line onto an ice shape and used solid state cameras to detect the light scattered by the ice. The instrument corrects the image for camera angle distortions, displays an outline of the ice shape on the computer screen, saves the data on a disk, and can print a full scale drawing of the ice shape. The profilometer has undergone extensive testing in the laboratory and in the NASA Lewis Icing Research Tunnel. Results of the tests show very good agreement between profilometer measurements and known simulated ice shapes and fair agreement between profilometer measurements and hand tracing techniques.
Optimal volume of injectate for fluoroscopy-guided cervical interlaminar epidural injection in patients with neck and upper extremity pain

PubMed Central

Park, Jun Young; Kim, Doo Hwan; Lee, Kunhee; Choi, Seong-Soo; Leem, Jeong-Gil

2016-01-01

Abstract There is no study of optimal volume of contrast medium to use in cervical interlaminar epidural injections (CIEIs) for appropriate spread to target lesions. To determine optimal volume of contrast medium to use in CIEIs. We analyzed the records of 80 patients who had undergone CIEIs. Patients were divided into 3 groups according to the amount of contrast: 3, 4.5, and 6 mL. The spread of medium to the target level was analyzed. Numerical rating scale data were also analyzed. The dye had spread to a point above the target level in 15 (78.9%), 22 (84.6%), and 32 (91.4%) patients in groups 1 to 3, respectively. The dye reached both sides in 14 (73.7%), 18 (69.2%), and 23 (65.7%) patients, and reached the ventral epidural space in 15 (78.9%), 22 (84.6%), and 30 (85.7%) patients, respectively. There were no significant differences of contrast spread among the groups. There were no significant differences in the numerical rating scale scores among the groups during the 3 months. When performing CIEIs, 3 mL medication is sufficient volume for the treatment of neck and upper-extremity pain induced by lower cervical degenerative disease. PMID:27787378
Optimal volume of injectate for fluoroscopy-guided cervical interlaminar epidural injection in patients with neck and upper extremity pain.

PubMed

Park, Jun Young; Kim, Doo Hwan; Lee, Kunhee; Choi, Seong-Soo; Leem, Jeong-Gil

2016-10-01

There is no study of optimal volume of contrast medium to use in cervical interlaminar epidural injections (CIEIs) for appropriate spread to target lesions. To determine optimal volume of contrast medium to use in CIEIs. We analyzed the records of 80 patients who had undergone CIEIs. Patients were divided into 3 groups according to the amount of contrast: 3, 4.5, and 6 mL. The spread of medium to the target level was analyzed. Numerical rating scale data were also analyzed. The dye had spread to a point above the target level in 15 (78.9%), 22 (84.6%), and 32 (91.4%) patients in groups 1 to 3, respectively. The dye reached both sides in 14 (73.7%), 18 (69.2%), and 23 (65.7%) patients, and reached the ventral epidural space in 15 (78.9%), 22 (84.6%), and 30 (85.7%) patients, respectively. There were no significant differences of contrast spread among the groups. There were no significant differences in the numerical rating scale scores among the groups during the 3 months. When performing CIEIs, 3 mL medication is sufficient volume for the treatment of neck and upper-extremity pain induced by lower cervical degenerative disease.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnes, P.; et al.

The DarkSide-50 experiment, located at the “Laboratori Nazionali del Gran Sasso (INFN)”, is based on low-radioactivity argon double phase time projection chamber, surrounded by an active liquid scintillator veto, designed for the zero background achievement. The liquid argon features sufficient self shielding and easy scalability to multi-tons scale. The impressive reduction of the 39Ar isotope (compared to the atmospheric argon), along with the excellent pulse shape discrimination, make this technology a possible candidate for the forthcoming generation of multi-ton Dark Matter experiments.
Assessment of Aedes albopictus (Skuse) clutch size in wild and laboratory populations

USDA-ARS?s Scientific Manuscript database

Aedes albopictus (Skuse) is an invasive mosquito species found across the southern U.S. and has undergone range expansion into many northern states. Although primarily pestiferous, it is a capable vector of many disease-causing pathogens. Intra- and interspecific larval competition have been evalu...
Evaluation of a permeable reactive barrier technology for use at Rocky Flats Environmental Technology Site (RFETS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

DWYER,BRIAN P.

2000-01-01

Three reactive materials were evaluated at laboratory scale to identify the optimum treatment reagent for use in a Permeable Reactive Barrier Treatment System at Rocky Flats Environmental Technology Site (RFETS). The contaminants of concern (COCS) are uranium, TCE, PCE, carbon tetrachloride, americium, and vinyl chloride. The three reactive media evaluated included high carbon steel iron filings, an iron-silica alloy in the form of a foam aggregate, and a peculiar humic acid based sorbent (Humasorb from Arctech) mixed with sand. Each material was tested in the laboratory at column scale using simulated site water. All three materials showed promise for themore » 903 Mound Site however, the iron filings were determined to be the least expensive media. In order to validate the laboratory results, the iron filings were further tested at a pilot scale (field columns) using actual site water. Pilot test results were similar to laboratory results; consequently, the iron filings were chosen for the fill-scale demonstration of the reactive barrier technology. Additional design parameters including saturated hydraulic conductivity, treatment residence time, and head loss across the media were also determined and provided to the design team in support of the final design. The final design was completed by the Corps of Engineers in 1997 and the system was constructed in the summer of 1998. The treatment system began fill operation in December, 1998 and despite a few problems has been operational since. Results to date are consistent with the lab and pilot scale findings, i.e., complete removal of the contaminants of concern (COCs) prior to discharge to meet RFETS cleanup requirements. Furthermore, it is fair to say at this point in time that laboratory developed design parameters for the reactive barrier technology are sufficient for fuel scale design; however,the treatment system longevity and the long-term fate of the contaminants are questions that remain unanswered. This project along with others such as the Durango, CO and Monticello, UT reactive barriers will provide the data to determine the long-term effectiveness and return on investment (ROI) for this technology for comparison to the baseline pump and treat.« less
Evaluation of advanced microelectronics for inclusion in MIL-STD-975

NASA Technical Reports Server (NTRS)

Scott, W. Richard

1991-01-01

The approach taken by NASA and JPL (Jet Propulsion Laboratory) in the development of a MIL-STD-975 section which contains advanced technology such as Large Scale Integration and Very Large Scale Integration (LSI/VLSI) microelectronic devices is described. The parts listed in this section are recommended as satisfactory for NASA flight applications, in the absence of alternate qualified devices, based on satisfactory results of a vendor capability audit, the availability of sufficient characterization and reliability data from the manufacturers and users and negotiated detail procurement specifications. The criteria used in the selection and evaluation of the vendors and candidate parts, the preparation of procurement specifications, and the status of this activity are discussed.
Coupled Physical/Chemical and Biofiltration Technologies to Reduce Air Emissions from Forest Products Industries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gary D. McGinnis

2001-12-31

The research is a laboratory and bench-scale investigation of a system to concentrate and destroy volatile organic compounds (VOCs), including hazardous air pollutants, formed from the drying of wood and the manufacture of wood board products (e.g., particle board and oriented strandboard). The approach that was investigated involved concentrating the dilute VOCs (<500 ppmv) with a physical/chemical adsorption unit, followed by the treatment of the concentrated voc stream (2,000 to 2,500 ppmv) with a biofiltration unit. The research program lasted three years, and involved three research organizations. Michigan Technological University was the primary recipient of the financial assistance, the USDAmore » Forest Products Laboratory (FPL) and Mississippi State University (MSU) were subcontractors to MTU. The ultimate objective of this research was to develop a pilot-scale demonstration of the technology with sufficient data to provide for the design of an industrial system. No commercialization activities were included in this project.« less

Argonne National Laboratory Annual Report of Laboratory Directed Research and Development program activities FY 2011.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Office of The Director)

As a national laboratory Argonne concentrates on scientific and technological challenges that can only be addressed through a sustained, interdisciplinary focus at a national scale. Argonne's eight major initiatives, as enumerated in its strategic plan, are Hard X-ray Sciences, Leadership Computing, Materials and Molecular Design and Discovery, Energy Storage, Alternative Energy and Efficiency, Nuclear Energy, Biological and Environmental Systems, and National Security. The purposes of Argonne's Laboratory Directed Research and Development (LDRD) Program are to encourage the development of novel technical concepts, enhance the Laboratory's research and development (R and D) capabilities, and pursue its strategic goals. projects are selectedmore » from proposals for creative and innovative R and D studies that require advance exploration before they are considered to be sufficiently developed to obtain support through normal programmatic channels. Among the aims of the projects supported by the LDRD Program are the following: establishment of engineering proof of principle, assessment of design feasibility for prospective facilities, development of instrumentation or computational methods or systems, and discoveries in fundamental science and exploratory development.« less
An overview of the roles and structure of international high-security veterinary laboratories for infectious animal diseases.

PubMed

Murray, P K

1998-08-01

The unique structure, role and operations of government high-security (HS) laboratories which work on animal diseases are described, with particular reference to the laboratories of nine countries. High-security laboratories provide cost-effective insurance against catastrophic losses which could occur following exotic disease outbreaks. The importance of these laboratories is reflected in the fact that several new laboratories have recently been constructed at considerable expense and older facilities have undergone major renovations. Biosecurity is fundamental to the operation of high-security laboratories, so good facility design and microbiological security practices are very important. High-security laboratories conduct exotic disease diagnosis, certification and surveillance, and also perform research into virology, disease pathogenesis and improvements to diagnostic tests and vaccines. The mandate of these laboratories includes the training of veterinarians in the recognition of exotic diseases. One extremely important role is the provision of expert advice on exotic diseases and participation (both nationally and internationally) in policy decisions regarding animal disease issues.
A survey of the satisfaction of patients who have undergone implant surgery with and without employing a computer-guided implant surgical template

PubMed Central

Youk, Shin-Young; Lee, Jee-Ho; Heo, Seong-Joo; Roh, Hyun-Ki; Park, Eun-Jin; Shin, Im Hee

2014-01-01

PURPOSE This study aims to investigate the degree of subjective pain and the satisfaction of patients who have undergone an implant treatment using a computer-guided template. MATERIALS AND METHODS A survey was conducted for 135 patients who have undergone implant surgery with and without the use of the computer-guided template during the period of 2012 and 2013 in university hospitals, dental hospitals and dental clinics that practiced implant surgery using the computer-guided template. Likert scale and VAS score were used in the survey questions, and the independent t-test and One-Way ANOVA were performed (α=.05). RESULTS The route that the subjects were introduced to the computer-guided implant surgery using a surgical template was mostly advices by dentists, and the most common reason for which they chose to undergo such surgery was that it was accurate and safe. Most of them gave an answer that they were willing to recommend it to others. The patients who have undergone the computer-guided implant surgery felt less pain during the operation and showed higher satisfaction than those who have undergone conventional implant surgery. Among the patients who have undergone computer-guided implant surgery, those who also had prior experience of surgery without a computer-guided template expressed higher satisfaction with the former (P<.05). CONCLUSION In this study, it could be seen that the patients who have undergone computer-guided implant surgery employing a surgical template felt less pain and had higher satisfaction than those with the conventional one, and the dentist's description could provide the confidence about the safety of surgery. PMID:25352962
Anaerobic Digestion of Laminaria japonica Waste from Industrial Production Residues in Laboratory- and Pilot-Scale.

PubMed

Barbot, Yann Nicolas; Thomsen, Claudia; Thomsen, Laurenz; Benz, Roland

2015-09-18

The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we explored the biochemical methane potential (BMP) and biomethane recovery of industrial Laminaria japonica waste (LJW) in batch, continuous laboratory and pilot-scale trials. Thermo-acidic pretreatment with industry-grade HCl or industrial flue gas condensate (FGC), as well as a co-digestion approach with maize silage (MS) did not improve the biomethane recovery. BMPs between 172 mL and 214 mL g(-1) volatile solids (VS) were recorded. We proved the feasibility of long-term continuous anaerobic digestion with LJW as sole feedstock showing a steady biomethane production rate of 173 mL g(-1) VS. The quality of fermentation residue was sufficient to serve as biofertilizer, with enriched amounts of potassium, sulfur and iron. We further demonstrated the upscaling feasibility of the process in a pilot-scale system where a CH₄ recovery of 189 L kg(-1) VS was achieved and a biogas composition of 55% CH₄ and 38% CO₂ was recorded.
Cell physiology at the Mount Desert Island Biological Laboratory: a brief look back and forward

PubMed Central

2011-01-01

The Mount Desert Island Biological Laboratory (MDIBL) has played important roles in the development of modern physiological concepts and tools, particularly in the fields of kidney and epithelial cell physiology. Over the last decade, MDIBL has undergone remarkable growth and evolution. This article will briefly review MDIBL's past and outline its future directions. It is hoped that this overview will renew and stimulate interest in MDIBL and, in particular, will encourage an even wider community of physiologists to participate in its ongoing growth and development. PMID:21068363
Elimination of the Reaction Rate "Scale Effect": Application of the Lagrangian Reactive Particle-Tracking Method to Simulate Mixing-Limited, Field-Scale Biodegradation at the Schoolcraft (MI, USA) Site

NASA Astrophysics Data System (ADS)

Ding, Dong; Benson, David A.; Fernández-Garcia, Daniel; Henri, Christopher V.; Hyndman, David W.; Phanikumar, Mantha S.; Bolster, Diogo

2017-12-01

Measured (or empirically fitted) reaction rates at groundwater remediation sites are typically much lower than those found in the same material at the batch or laboratory scale. The reduced rates are commonly attributed to poorer mixing at the larger scales. A variety of methods have been proposed to account for this scaling effect in reactive transport. In this study, we use the Lagrangian particle-tracking and reaction (PTR) method to simulate a field bioremediation experiment at the Schoolcraft, MI site. A denitrifying bacterium, Pseudomonas Stutzeri strain KC (KC), was injected to the aquifer, along with sufficient substrate, to degrade the contaminant, carbon tetrachloride (CT), under anaerobic conditions. The PTR method simulates chemical reactions through probabilistic rules of particle collisions, interactions, and transformations to address the scale effect (lower apparent reaction rates for each level of upscaling, from batch to column to field scale). In contrast to a prior Eulerian reaction model, the PTR method is able to match the field-scale experiment using the rate coefficients obtained from batch experiments.
Mission and Objectives for the X-1 Advanced Radiation Source*

NASA Astrophysics Data System (ADS)

Rochau, Gary E.; Ramirez, Juan J.; Raglin, Paul S.

1998-11-01

Sandia National Laboratories PO Box 5800, MS-1178, Albuquerque, NM 87185 The X-1 Advanced Radiation Source represents a next step in providing the U.S. Department of Energy's Stockpile Stewardship Program with the high-energy, large volume, laboratory x-ray source for the Radiation Effects Science and Simulation, Inertial Confinement Fusion, and Weapon Physics Programs. Advances in fast pulsed power technology and in z-pinch hohlraums on Sandia National Laboratories' Z Accelerator provide sufficient basis for pursuing the development of X-1. The X-1 plan follows a strategy based on scaling the 2 MJ x-ray output on Z via a 3-fold increase in z-pinch load current. The large volume (>5 cm3), high temperature (>150 eV), temporally long (>10 ns) hohlraums are unique outside of underground nuclear weapon testing. Analytical scaling arguments and hydrodynamic simulations indicate that these hohlraums at temperatures of 230-300 eV will ignite thermonuclear fuel and drive the reaction to a yield of 200 to 1,200 MJ in the laboratory. Non-ignition sources will provide cold x-ray environments (<15 keV) and high yield fusion burn sources will provide high fidelity warm x-ray environments (15 keV-80 keV). This paper will introduce the X-1 Advanced Radiation Source Facility Project, describe the project mission, objective, and preliminary schedule.
Compositional studies of primitive asteroids

NASA Technical Reports Server (NTRS)

Vilas, Faith

1991-01-01

Primitive asteroids in the solar system (C, P, D class and associated subclasses) are believed to have undergone less thermal processing compared with the differential (S class) asteroids. Telescopic spectra of C class asteroids show effects of aqueous alteration products produced when heating of the asteroids was sufficient to melt surface water, but not strong enough to produce differentiation. Spectrum analysis of P and D class asteroids suggests that aqueous alteration terminated in the outer belt and did not operate at the distance of Jupiter's orbit.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, Frank; Popp, Till; Wieczorek, Klaus

The purposes of this paper are to review the vast amount of knowledge concerning crushed salt reconsolidation and its attendant hydraulic properties (i.e., its capability for fluid or gas transport) and to provide a sufficient basis to understand reconsolidation and healing rates under repository conditions. Topics covered include: deformation mechanisms and hydro-mechanical interactions during reconsolidation; the experimental data base pertaining to crushed salt reconsolidation; transport properties of consolidating granulated salt and provides quantitative substantiation of its evolution to characteristics emulating undisturbed rock salt; and extension of microscopic and laboratory observations and data to the applicable field scale.
Scale-up considerations for surface collecting agent assisted in-situ burn crude oil spill response experiments in the Arctic: Laboratory to field-scale investigations.

PubMed

Bullock, Robin J; Aggarwal, Srijan; Perkins, Robert A; Schnabel, William

2017-04-01

In the event of a marine oil spill in the Arctic, government agencies, industry, and the public have a stake in the successful implementation of oil spill response. Because large spills are rare events, oil spill response techniques are often evaluated with laboratory and meso-scale experiments. The experiments must yield scalable information sufficient to understand the operability and effectiveness of a response technique under actual field conditions. Since in-situ burning augmented with surface collecting agents ("herders") is one of the few viable response options in ice infested waters, a series of oil spill response experiments were conducted in Fairbanks, Alaska, in 2014 and 2015 to evaluate the use of herders to assist in-situ burning and the role of experimental scale. This study compares burn efficiency and herder application for three experimental designs for in-situ burning of Alaska North Slope crude oil in cold, fresh waters with ∼10% ice cover. The experiments were conducted in three project-specific constructed venues with varying scales (surface areas of approximately 0.09 square meters, 9 square meters and 8100 square meters). The results from the herder assisted in-situ burn experiments performed at these three different scales showed good experimental scale correlation and no negative impact due to the presence of ice cover on burn efficiency. Experimental conclusions are predominantly associated with application of the herder material and usability for a given experiment scale to make response decisions. Copyright © 2016 Elsevier Ltd. All rights reserved.
Open-circuit respirometry: a brief historical review of the use of Douglas bags and chemical analyzers.

PubMed

Shephard, Roy J

2017-03-01

The Douglas bag technique is reviewed as one in a series of articles looking at historical insights into measurement of whole body metabolic rate. Consideration of all articles looking at Douglas bag technique and chemical gas analysis has here focused on the growing appreciation of errors in measuring expired volumes and gas composition, and subjective reactions to airflow resistance and dead space. Multiple small sources of error have been identified and appropriate remedies proposed over a century of use of the methodology. Changes in the bag lining have limited gas diffusion, laboratories conducting gas analyses have undergone validation, and WHO guidelines on airflow resistance have minimized reactive effects. One remaining difficulty is a contamination of expirate by dead space air, minimized by keeping the dead space <70 mL. Care must also be taken to ensure a steady state, and formal validation of the Douglas bag method still needs to be carried out. We may conclude that the Douglas bag method has helped to define key concepts in exercise physiology. Although now superceded in many applications, the errors in a meticulously completed measurement are sufficiently low to warrant retention of the Douglas bag as the gold standard when evaluating newer open-circuit methodology.
Bridging the gap between sample collection and laboratory analysis: using dried blood spots to identify human exposure to chemical agents

NASA Astrophysics Data System (ADS)

Hamelin, Elizabeth I.; Blake, Thomas A.; Perez, Jonas W.; Crow, Brian S.; Shaner, Rebecca L.; Coleman, Rebecca M.; Johnson, Rudolph C.

2016-05-01

Public health response to large scale chemical emergencies presents logistical challenges for sample collection, transport, and analysis. Diagnostic methods used to identify and determine exposure to chemical warfare agents, toxins, and poisons traditionally involve blood collection by phlebotomists, cold transport of biomedical samples, and costly sample preparation techniques. Use of dried blood spots, which consist of dried blood on an FDA-approved substrate, can increase analyte stability, decrease infection hazard for those handling samples, greatly reduce the cost of shipping/storing samples by removing the need for refrigeration and cold chain transportation, and be self-prepared by potentially exposed individuals using a simple finger prick and blood spot compatible paper. Our laboratory has developed clinical assays to detect human exposures to nerve agents through the analysis of specific protein adducts and metabolites, for which a simple extraction from a dried blood spot is sufficient for removing matrix interferents and attaining sensitivities on par with traditional sampling methods. The use of dried blood spots can bridge the gap between the laboratory and the field allowing for large scale sample collection with minimal impact on hospital resources while maintaining sensitivity, specificity, traceability, and quality requirements for both clinical and forensic applications.
Quantitative Tracking of Combinatorially Engineered Populations with Multiplexed Binary Assemblies.

PubMed

Zeitoun, Ramsey I; Pines, Gur; Grau, Willliam C; Gill, Ryan T

2017-04-21

Advances in synthetic biology and genomics have enabled full-scale genome engineering efforts on laboratory time scales. However, the absence of sufficient approaches for mapping engineered genomes at system-wide scales onto performance has limited the adoption of more sophisticated algorithms for engineering complex biological systems. Here we report on the development and application of a robust approach to quantitatively map combinatorially engineered populations at scales up to several dozen target sites. This approach works by assembling genome engineered sites with cell-specific barcodes into a format compatible with high-throughput sequencing technologies. This approach, called barcoded-TRACE (bTRACE) was applied to assess E. coli populations engineered by recursive multiplex recombineering across both 6-target sites and 31-target sites. The 31-target library was then tracked throughout growth selections in the presence and absence of isopentenol (a potential next-generation biofuel). We also use the resolution of bTRACE to compare the influence of technical and biological noise on genome engineering efforts.
Evaluation of analytical performance based on partial order methodology.

PubMed

Carlsen, Lars; Bruggemann, Rainer; Kenessova, Olga; Erzhigitov, Erkin

2015-01-01

Classical measurements of performances are typically based on linear scales. However, in analytical chemistry a simple scale may be not sufficient to analyze the analytical performance appropriately. Here partial order methodology can be helpful. Within the context described here, partial order analysis can be seen as an ordinal analysis of data matrices, especially to simplify the relative comparisons of objects due to their data profile (the ordered set of values an object have). Hence, partial order methodology offers a unique possibility to evaluate analytical performance. In the present data as, e.g., provided by the laboratories through interlaboratory comparisons or proficiency testings is used as an illustrative example. However, the presented scheme is likewise applicable for comparison of analytical methods or simply as a tool for optimization of an analytical method. The methodology can be applied without presumptions or pretreatment of the analytical data provided in order to evaluate the analytical performance taking into account all indicators simultaneously and thus elucidating a "distance" from the true value. In the present illustrative example it is assumed that the laboratories analyze a given sample several times and subsequently report the mean value, the standard deviation and the skewness, which simultaneously are used for the evaluation of the analytical performance. The analyses lead to information concerning (1) a partial ordering of the laboratories, subsequently, (2) a "distance" to the Reference laboratory and (3) a classification due to the concept of "peculiar points". Copyright © 2014 Elsevier B.V. All rights reserved.
Anaerobic Digestion of Laminaria japonica Waste from Industrial Production Residues in Laboratory- and Pilot-Scale

PubMed Central

Barbot, Yann Nicolas; Thomsen, Claudia; Thomsen, Laurenz; Benz, Roland

2015-01-01

The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we explored the biochemical methane potential (BMP) and biomethane recovery of industrial Laminaria japonica waste (LJW) in batch, continuous laboratory and pilot-scale trials. Thermo-acidic pretreatment with industry-grade HCl or industrial flue gas condensate (FGC), as well as a co-digestion approach with maize silage (MS) did not improve the biomethane recovery. BMPs between 172 mL and 214 mL g−1 volatile solids (VS) were recorded. We proved the feasibility of long-term continuous anaerobic digestion with LJW as sole feedstock showing a steady biomethane production rate of 173 mL g−1 VS. The quality of fermentation residue was sufficient to serve as biofertilizer, with enriched amounts of potassium, sulfur and iron. We further demonstrated the upscaling feasibility of the process in a pilot-scale system where a CH4 recovery of 189 L kg−1 VS was achieved and a biogas composition of 55% CH4 and 38% CO2 was recorded. PMID:26393620
Laboratory medicine in France. A jeopardized situation.

PubMed

Valdiguié, P M; de Graeve, J S; Guerre, J P

1997-11-06

The expenses for health care in France have risen considerably during the present decade, ranking third after USA and Canada in the Western world. In spite of the very low cost of laboratory medicine (2.4% of the total expenditure in 1995), clinical laboratories have undergone a severe squeeze, due to two limiting factors; a decrease in the ordering of laboratory tests from private physicians and a reduction in the total expenses for laboratory services from the Social Security. Consequently, there has been unemployment of technical and secretarial staff and severe restriction in investment for buying new equipment. However, hospital laboratories will manage to assume their challenge in developing robotics, automation, molecular pathology techniques and expert systems. Private laboratories, in spite of their efforts to follow the technological advances in automation, will survive thanks to consolidation of regional networks that operate in a cooperative rather than competitive mode. Therefore, the challenge will be not in the adaptation of clinical laboratories, but in the limitation of overspending at the national level and in modification of the behaviour of irresponsible citizens accustomed to spending freely on health care services.
Trickle-bed root culture bioreactor design and scale-up: growth, fluid-dynamics, and oxygen mass transfer.

PubMed

Ramakrishnan, Divakar; Curtis, Wayne R

2004-10-20

Trickle-bed root culture reactors are shown to achieve tissue concentrations as high as 36 g DW/L (752 g FW/L) at a scale of 14 L. Root growth rate in a 1.6-L reactor configuration with improved operational conditions is shown to be indistinguishable from the laboratory-scale benchmark, the shaker flask (mu=0.33 day(-1)). These results demonstrate that trickle-bed reactor systems can sustain tissue concentrations, growth rates and volumetric biomass productivities substantially higher than other reported bioreactor configurations. Mass transfer and fluid dynamics are characterized in trickle-bed root reactors to identify appropriate operating conditions and scale-up criteria. Root tissue respiration goes through a minimum with increasing liquid flow, which is qualitatively consistent with traditional trickle-bed performance. However, liquid hold-up is much higher than traditional trickle-beds and alternative correlations based on liquid hold-up per unit tissue mass are required to account for large changes in biomass volume fraction. Bioreactor characterization is sufficient to carry out preliminary design calculations that indicate scale-up feasibility to at least 10,000 liters.
The Evolution of the Celsius and Kelvin Temperature Scales and the State of the Art

NASA Astrophysics Data System (ADS)

Pellicer, Julio; Amparo Gilabert, M.; Lopez-Baeza, Ernesto

1999-07-01

A physical analysis is given of the evolution undergone by the Celsius and Kelvin temperature scales, from their definition to the present day. It is shown that in the temperature interval between the melting point of ice and the boiling point of water, the Celsius and Kelvin scales, both born centigrade by definition and actually become so afterwards by experimental determination as well, are not so any longer, either by definition or by experimental determination.
Quality and future of clinical laboratories: the Vico's whole cyclical theory of the recurring cycles.

PubMed

Plebani, Mario

2018-05-24

In the last few decades, laboratory medicine has undergone monumental changes, and laboratory technology, which has made enormous advances, now has new clinical applications thanks to the identification of a growing number of biomarkers and risk factors conducive to the promotion of predictive and preventive interventions that have enhanced the role of laboratory medicine in health care delivering. However, the paradigm shift in the past 50 years has led to a gap between laboratory and clinic, with an increased risk of inappropriateness in test request and interpretation, as well as the consolidation of analytical work in focused factories and megastructurers oriented only toward achieving greater volumes, decreasing cost per test and generating a vision of laboratory services as simple commodities. A careful historical revision of the changing models for delivering laboratory services in the United States leads to the prediction that there are several reasons for counteracting the vision of clinical laboratory as a commodity, and restoring the true nature of laboratory services as an integral part of the diagnosis and therapy process. The present study, which reports on internal and external drivers for change, proposes an integrated vision of quality in laboratory medicine.
Laboratory analogue of a supersonic accretion column in a binary star system.

PubMed

Cross, J E; Gregori, G; Foster, J M; Graham, P; Bonnet-Bidaud, J-M; Busschaert, C; Charpentier, N; Danson, C N; Doyle, H W; Drake, R P; Fyrth, J; Gumbrell, E T; Koenig, M; Krauland, C; Kuranz, C C; Loupias, B; Michaut, C; Mouchet, M; Patankar, S; Skidmore, J; Spindloe, C; Tubman, E R; Woolsey, N; Yurchak, R; Falize, É

2016-06-13

Astrophysical flows exhibit rich behaviour resulting from the interplay of different forms of energy-gravitational, thermal, magnetic and radiative. For magnetic cataclysmic variable stars, material from a late, main sequence star is pulled onto a highly magnetized (B>10 MG) white dwarf. The magnetic field is sufficiently large to direct the flow as an accretion column onto the poles of the white dwarf, a star subclass known as AM Herculis. A stationary radiative shock is expected to form 100-1,000 km above the surface of the white dwarf, far too small to be resolved with current telescopes. Here we report the results of a laboratory experiment showing the evolution of a reverse shock when both ionization and radiative losses are important. We find that the stand-off position of the shock agrees with radiation hydrodynamic simulations and is consistent, when scaled to AM Herculis star systems, with theoretical predictions.

Multiscale tomographic analysis of heterogeneous cast Al-Si-X alloys.

PubMed

Asghar, Z; Requena, G; Sket, F

2015-07-01

The three-dimensional microstructure of cast AlSi12Ni and AlSi10Cu5Ni2 alloys is investigated by laboratory X-ray computed tomography, synchrotron X-ray computed microtomography, light optical tomography and synchrotron X-ray computed microtomography with submicrometre resolution. The results obtained with each technique are correlated with the size of the scanned volumes and resolved microstructural features. Laboratory X-ray computed tomography is sufficient to resolve highly absorbing aluminides but eutectic and primary Si remain unrevealed. Synchrotron X-ray computed microtomography at ID15/ESRF gives better spatial resolution and reveals primary Si in addition to aluminides. Synchrotron X-ray computed microtomography at ID19/ESRF reveals all the phases ≥ ∼1 μm in volumes about 80 times smaller than laboratory X-ray computed tomography. The volumes investigated by light optical tomography and submicrometre synchrotron X-ray computed microtomography are much smaller than laboratory X-ray computed tomography but both techniques provide local chemical information on the types of aluminides. The complementary techniques applied enable a full three-dimensional characterization of the microstructure of the alloys at length scales ranging over six orders of magnitude. © 2015 The Authors Journal of Microscopy © 2015 Royal Microscopical Society.
Quality-of-Life Assessment of Fibroid Treatment Options and Outcomes

PubMed Central

Kong, Chung Yin; Tempany, Clare M.; Swan, J. Shannon

2011-01-01

Purpose: To obtain utilities (a unit of measure of a person’s relative preferences for different health states compared with death or worst possible outcome) for uterine fibroids before and after treatment and to measure short-term utilities for the following uterine fibroid treatments: abdominal hysterectomy, magnetic resonance (MR) imaging–guided focused ultrasound surgery, and uterine artery embolization (UAE). Materials and Methods: This retrospective study was approved by the institutional review board and was HIPAA compliant. The waiting trade-off (WTO) method, a variation on the time trade-off (TTO) method, is used to obtain utilities for diagnostic procedures on the basis of the fact that people wait longer to avoid noxious tests and/or procedures. The WTO method provides short-term quality of life tolls in terms of quality-adjusted life-weeks by scaling wait times with pre- and posttreatment utilities. Utilities for uterine fibroids before and after treatment were obtained with the TTO method and a visual analog scale (VAS) by using a questionnaire administered by means of a phone interview. WTO wait times were adjusted for quality of life with VAS and TTO utilities and a transformation of VAS. Wait times were compared by using nonparametric tests. The study participants included 62 patients who had undergone abdominal hysterectomy, 74 who had undergone UAE, and 61 who had undergone MR imaging–guided focused ultrasound surgery. Results: Quality of life increased with all treatments. The median WTO wait time was higher for hysterectomy (21.6 weeks) than for UAE or MR imaging–guided focused ultrasound surgery (14.1 weeks for both) (P < .05). Quality-adjusted life-week tolls were smaller when scaled according to TTO than when scaled according to VAS or transformation of VAS. Conclusion: Quality of life increased after all fibroid treatments. WTO is feasible for assessing the quality-adjusted morbidity of treatment procedures. © RSNA, 2011 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11100704/-/DC1 PMID:21364084
The suitability of ultrafine coal as an industrial boiler fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barratt, D.J.; Roberts, P.T.

1989-07-01

Coal that was finely ground to a mean particle size of 12 /mu/m produced a hotter, shorter flame compared to normal pulverized fuel in a pilot scale combustor. Measurements indicated that, should this fuel be fired in an industrial boiler, the rate of ash deposition on the walls and convection tubes could be low, but that the thin ash deposits that were produced might be more highly insulating and would therefore require more frequent cleaning. A mathematical model, using reactivity and pyrolysis data measured in laboratory-scale apparatus, has been used to predict the heat release rate within a boiler. Thismore » would be sufficiently high to allow a premium-quality finely ground coal to be burned in many boilers originally designed for oil firing, provided that burner mixing patterns were optimized.« less
Does an inter-flaw length control the accuracy of rupture forecasting in geological materials?

NASA Astrophysics Data System (ADS)

Vasseur, Jérémie; Wadsworth, Fabian B.; Heap, Michael J.; Main, Ian G.; Lavallée, Yan; Dingwell, Donald B.

2017-10-01

Multi-scale failure of porous materials is an important phenomenon in nature and in material physics - from controlled laboratory tests to rockbursts, landslides, volcanic eruptions and earthquakes. A key unsolved research question is how to accurately forecast the time of system-sized catastrophic failure, based on observations of precursory events such as acoustic emissions (AE) in laboratory samples, or, on a larger scale, small earthquakes. Until now, the length scale associated with precursory events has not been well quantified, resulting in forecasting tools that are often unreliable. Here we test the hypothesis that the accuracy of the forecast failure time depends on the inter-flaw distance in the starting material. We use new experimental datasets for the deformation of porous materials to infer the critical crack length at failure from a static damage mechanics model. The style of acceleration of AE rate prior to failure, and the accuracy of forecast failure time, both depend on whether the cracks can span the inter-flaw length or not. A smooth inverse power-law acceleration of AE rate to failure, and an accurate forecast, occurs when the cracks are sufficiently long to bridge pore spaces. When this is not the case, the predicted failure time is much less accurate and failure is preceded by an exponential AE rate trend. Finally, we provide a quantitative and pragmatic correction for the systematic error in the forecast failure time, valid for structurally isotropic porous materials, which could be tested against larger-scale natural failure events, with suitable scaling for the relevant inter-flaw distances.
A Streamlined Protocol for Molecular Testing of the DMD Gene within a Diagnostic Laboratory: A Combination of Array Comparative Genomic Hybridization and Bidirectional Sequence Analysis

PubMed Central

Marquis-Nicholson, Renate; Lai, Daniel; Love, Jennifer M.; Love, Donald R.

2013-01-01

Purpose. The aim of this study was to develop a streamlined mutation screening protocol for the DMD gene in order to confirm a clinical diagnosis of Duchenne or Becker muscular dystrophy in affected males and to clarify the carrier status of female family members. Methods. Sequence analysis and array comparative genomic hybridization (aCGH) were used to identify mutations in the dystrophin DMD gene. We analysed genomic DNA from six individuals with a range of previously characterised mutations and from eight individuals who had not previously undergone any form of molecular analysis. Results. We successfully identified the known mutations in all six patients. A molecular diagnosis was also made in three of the four patients with a clinical diagnosis who had not undergone prior genetic screening, and testing for familial mutations was successfully completed for the remaining four patients. Conclusion. The mutation screening protocol described here meets best practice guidelines for molecular testing of the DMD gene in a diagnostic laboratory. The aCGH method is a superior alternative to more conventional assays such as multiplex ligation-dependent probe amplification (MLPA). The combination of aCGH and sequence analysis will detect mutations in 98% of patients with the Duchenne or Becker muscular dystrophy. PMID:23476807
Two-Step Incision for Periarterial Sympathectomy of the Hand.

PubMed

Jeon, Seung Bae; Ahn, Hee Chang; Ahn, Yong Su; Choi, Matthew Seung Suk

2015-11-01

Surgical scars on the palmar surface of the hand may lead to functional and also aesthetic and psychological consequences. The objective of this study was to introduce a new incision technique for periarterial sympathectomy of the hand and to compare the results of the new two-step incision technique with those of a Koman incision by using an objective questionnaire. A total of 40 patients (17 men and 23 women) with intractable Raynaud's disease or syndrome underwent surgery in our hospital, conducted by a single surgeon, between January 2008 and January 2013. Patients who had undergone extended sympathectomy or vessel graft were excluded. Clinical evaluation of postoperative scars was performed in both groups one year after surgery using the patient and observer scar assessment scale (POSAS) and the Wake Forest University rating scale. The total patient score was 8.59 (range, 6-15) in the two-step incision group and 9.62 (range, 7-18) in the Koman incision group. A significant difference was found between the groups in the total PS score (P-value=0.034) but not in the total observer score. Our analysis found no significant difference in preoperative and postoperative Wake Forest University rating scale scores between the two-step and Koman incision groups. The time required for recovery prior to returning to work after surgery was shorter in the two-step incision group, with a mean of 29.48 days in the two-step incision group and 34.15 days in the Koman incision group (P=0.03). Compared to the Koman incision, the new two-step incision technique provides better aesthetic results, similar symptom improvement, and a reduction in the recovery time required before returning to work. Furthermore, this incision allows the surgeon to access a wide surgical field and a sufficient exposure of anatomical structures.
Translation and cross-cultural adaptation of the anterior cruciate ligament-return to sport after injury (ACL-RSI) scale into Turkish.

PubMed

Harput, Gulcan; Tok, Damla; Ulusoy, Burak; Eraslan, Leyla; Yildiz, Taha Ibrahim; Turgut, Elif; Demirci, Serdar; Duzgun, Irem; Tunay, Volga Bayrakci; Baltaci, Gul; Ergun, Nevin

2017-01-01

To translate and culturally adapt the anterior cruciate ligament-return to sport after injury (ACL-RSI) scale into Turkish (ACL-RSI-Tr) and examine and evaluate the psychometric properties of the Turkish version in individuals who have undergone anterior cruciate ligament (ACL) reconstruction. The ACL-RSI was forward- and back-translated, culturally adapted and validated on ninety-three Turkish individuals who had undergone ACL reconstruction (5 females, 88 males; age 28.7 ± 8.6 years; body mass 80.1 ± 13.9 kg; height 178.8 ± 6.9 cm; body mass index 25.0 ± 3.7 kg/m 2 ). All patients completed the translated ACL-RSI, Tampa Scale of Kinesiophobia (TSK), Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Documentary Committee (IKDC) and Lysholm questionnaires. We then analysed the internal consistency, reliability and validity of the newly formed ACL-RSI-Tr scale. The ACL-RSI-Tr showed good internal consistency (Cronbach's alpha 0.86) and test-retest reliability (ICC 0.92) and was significantly correlated with the KOOS 'quality of life' (r = 0.58, p < 0.002), 'symptoms and stiffness' (r = 0.35, p = 0.001), 'pain' (r = 0.49, p < 0.001), 'sports' (r = 0.44, p < 0.001) and 'daily life' (r = 0.42, p < 0.001) subscales. The ACL-RSI-Tr also correlated significantly with the TSK (r = - 0.45, p < 0.001), Lysholm (r = 0.45, p < 0.001) and IKDC (r = 0.44, p < 0.001) scores. The Turkish version of the ACL-RSI scale was valid, discriminant, consistent and reliable in patients who had undergone ACL reconstruction. This score could be useful to evaluate the effect of psychological factors on return to sport following ACL surgery. Diagnostic study, Level I.
NASA Applications of Molecular Nanotechnology

NASA Technical Reports Server (NTRS)

Globus, Al; Bailey, David; Han, Jie; Jaffe, Richard; Levit, Creon; Merkle, Ralph; Srivastava, Deepak

1998-01-01

Laboratories throughout the world are rapidly gaining atomically precise control over matter. As this control extends to an ever wider variety of materials, processes and devices, opportunities for applications relevant to NASA's missions will be created. This document surveys a number of future molecular nanotechnology capabilities of aerospace interest. Computer applications, launch vehicle improvements, and active materials appear to be of particular interest. We also list a number of applications for each of NASA's enterprises. If advanced molecular nanotechnology can be developed, almost all of NASA's endeavors will be radically improved. In particular, a sufficiently advanced molecular nanotechnology can arguably bring large scale space colonization within our grasp.
Massive juvenile nasopharyngeal angiofibroma: ode to the open surgical approach.

PubMed

Meher, Ravi; Arora, Nikhil; Bhargava, Eishaan Kamta; Juneja, Ruchika

2017-08-01

The management of juvenile nasopharyngeal angiofibroma has undergone a significant evolution, with more surgeons moving towards the minimal invasive endoscopic approaches. Although considered the standard of care by most, an endoscopic approach may not be sufficient for extensive tumours, as exemplified by the current case of a young man presenting with the largest juvenile nasopharyngeal angiofibroma described in English literature until the present that was eventually excised via an anterior external approach. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Anaerobic co-digestion of high-strength organic wastes pretreated by thermal hydrolysis.

PubMed

Choi, Gyucheol; Kim, Jaai; Lee, Seungyong; Lee, Changsoo

2018-06-01

Thermal hydrolysis (TH) pretreatment was investigated for the anaerobic digestion (AD) of a mixture of high-strength organic wastes (i.e., dewatered human feces, dewatered sewage sludge, and food wastewater) at laboratory scale to simulate a full-scale plant and evaluate its feasibility. The reactors maintained efficient and stable performance at a hydraulic retention time of 20 days, which may be not sufficient for the mesophilic AD of high-suspended-solid wastes, despite the temporal variations in organic load. The addition of FeCl 3 was effective in controlling H 2 S and resulted in significant changes in the microbial community structure, particularly the methanogens. The temporary interruption in feeding or temperature control led to immediate performance deterioration, but it recovered rapidly when normal operations were resumed. The overall results suggest that the AD process coupled with TH pretreatment can provide an efficient, robust, and resilient system to manage high-suspended-solid wastes, supporting the feasibility of its full-scale implementation. Copyright © 2018 Elsevier Ltd. All rights reserved.
Fumigation of Jute Bags with Ethylene Oxide and Methyl Bromide to Eradicate Potato Ring Rot Bacteria1

PubMed Central

Richardson, L. T.; Monro, H. A. U.

1962-01-01

In a series of full-scale tests, the effectiveness of various fumigant treatments for the eradication of potato ring rot bacteria from bulk lots of contaminated jute bags was evaluated. Survival of these bacteria on infested sample fibers located at various positions within and around a tightly wired bale was determined quantitatively from the growth lag in a liquid medium as indicated by the rate of turbidity development. Ethylene oxide, though highly toxic to Corynebacterium sepedonicum in laboratory tests, failed to penetrate the jute sufficiently to be effective in the interior of a bale. Methyl bromide showed better penetration, but was not sufficiently toxic at practical dosage levels. A mixture of 5% ethylene oxide and 10% methyl bromide achieved complete eradication throughout a bale in an 18-hr exposure period. On the basis of these results, eradication of ring rot bacteria from contaminated jute bags by fumigation with a combination of these two gases would appear to be feasible under commercial conditions. PMID:13982125
The economic payoff for a state-of-the-art high-efficiency flat-plate crystalline silicon solar cell technology

NASA Technical Reports Server (NTRS)

Bickler, Donald B.; Callaghan, W. T.

1987-01-01

In 1986 during the flat-plate solar array project, silicon solar cells 4.0 sq cm in area were fabricated at the Jet Propulsion Laboratory (JPL) with a conversion efficiency of 20.1 percent (AM1.5-global). Sixteen cells were processed with efficiencies measuring 19.5 percent (AM1.5 global) or better. These cells were produced using refined versions of conventional processing methods, aside from certain advanced techniques that bring about a significant reduction in a major mechanism (surface recombination) that limits cell efficiency. Wacker Siltronic p-type float-zone 0.18-ohm-cm wafers were used. Conversion efficiencies in this range have previously been reported by other researchers, but generally on much smaller (0.5 vs. 4.0 cm) devices which have undergone sophisticated and costly processing steps. An economic analysis is presented of the potential payoffs for this approach, using the Solar Array Manufacturing Industry Costing Standards (SAMICS) methodology. The process sequence used and the assumptions made for capturing the economies of scale are presented.
High-precision measurements of wetland sediment elevation. I. Recent improvements to the sedimentation--erosion table

USGS Publications Warehouse

Cahoon, D.R.; Lynch, J.C.; Hensel, P.; Boumans, R.; Perez, B.C.; Segura, B.; Day, J.W.

2002-01-01

The sedimentation-erosion table (SET) developed by Boumans and Day (1993) is herein renamed the surface elevation table (SET) to better reflect the conceptual view of the processes being measured. The SET was designed for making high-resolution measurements of small-scale changes in elevation of loose, unconsolidated sediments in shallow water and mudflat habitats. The SET has undergone three major improvements to increase precision and so that it can be used to measure sediment elevation in vegetated wetlands as well as shallow water habitats. The remote-release 'sliding plate' mechanism has been replaced with a single plate, collars (first 2.5 cm then 7.5 cm in length) have been attached to the plate to reduce play in the placement of the measuring pins, and the brass measuring pins have been replaced with fiberglass pins to reduce bending and consequent loss of precision. Under ideal laboratory conditions, the 95% confidence limit for individual pin measurements averaged about A? 1.4 mm (range A? 0.7 to A? 1.9 mm). These modifications have resulted in a reduction of error by about 50%.
Correlation, necessity, and sufficiency: Common errors in the scientific reasoning of undergraduate students for interpreting experiments.

PubMed

Coleman, Aaron B; Lam, Diane P; Soowal, Lara N

2015-01-01

Gaining an understanding of how science works is central to an undergraduate education in biology and biochemistry. The reasoning required to design or interpret experiments that ask specific questions does not come naturally, and is an essential part of the science process skills that must be learned for an understanding of how scientists conduct research. Gaps in these reasoning skills make it difficult for students to become proficient in reading primary scientific literature. In this study, we assessed the ability of students in an upper-division biochemistry laboratory class to use the concepts of correlation, necessity, and sufficiency in interpreting experiments presented in a format and context that is similar to what they would encounter when reading a journal article. The students were assessed before and after completion of a laboratory module where necessary vs. sufficient reasoning was used to design and interpret experiments. The assessment identified two types of errors that were commonly committed by students when interpreting experimental data. When presented with an experiment that only establishes a correlation between a potential intermediate and a known effect, students frequently interpreted the intermediate as being sufficient (causative) for the effect. Also, when presented with an experiment that tests only necessity for an intermediate, they frequently made unsupported conclusions about sufficiency, and vice versa. Completion of the laboratory module and instruction in necessary vs. sufficient reasoning showed some promise for addressing these common errors. © 2015 The International Union of Biochemistry and Molecular Biology.
Innovative mathematical modeling in environmental remediation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yeh, Gour T.; National Central Univ.; Univ. of Central Florida

2013-05-01

There are two different ways to model reactive transport: ad hoc and innovative reaction-based approaches. The former, such as the Kd simplification of adsorption, has been widely employed by practitioners, while the latter has been mainly used in scientific communities for elucidating mechanisms of biogeochemical transport processes. It is believed that innovative mechanistic-based models could serve as protocols for environmental remediation as well. This paper reviews the development of a mechanistically coupled fluid flow, thermal transport, hydrologic transport, and reactive biogeochemical model and example-applications to environmental remediation problems. Theoretical bases are sufficiently described. Four example problems previously carried out aremore » used to demonstrate how numerical experimentation can be used to evaluate the feasibility of different remediation approaches. The first one involved the application of a 56-species uranium tailing problem to the Melton Branch Subwatershed at Oak Ridge National Laboratory (ORNL) using the parallel version of the model. Simulations were made to demonstrate the potential mobilization of uranium and other chelating agents in the proposed waste disposal site. The second problem simulated laboratory-scale system to investigate the role of natural attenuation in potential off-site migration of uranium from uranium mill tailings after restoration. It showed inadequacy of using a single Kd even for a homogeneous medium. The third example simulated laboratory experiments involving extremely high concentrations of uranium, technetium, aluminum, nitrate, and toxic metals (e.g.,Ni, Cr, Co).The fourth example modeled microbially-mediated immobilization of uranium in an unconfined aquifer using acetate amendment in a field-scale experiment. The purposes of these modeling studies were to simulate various mechanisms of mobilization and immobilization of radioactive wastes and to illustrate how to apply reactive transport models for environmental remediation.The second problem simulated laboratory-scale system to investigate the role of natural attenuation in potential off-site migration of uranium from uranium mill tailings after restoration. It showed inadequacy of using a single Kd even for a homogeneous medium.« less
Landscape and environmental controls over leaf and ecosystem carbon dioxide fluxes under woody plant expansion

USDA-ARS?s Scientific Manuscript database

Many regions of the globe are experiencing a simultaneous change in the dominant plant functional type and regional climatology. We explored how atmospheric temperature and precipitation input control leaf- and ecosystem scale carbon fluxes within a pair of semiarid shrublands that had undergone woo...
INCIDENCE OF CORAL DISEASE IN THE FLORIDA KEYS AND DRY TORTUGAS (ABSTRACT)

EPA Science Inventory

Disease in corals is one factor that has been implicated in serious declines in the ecological condition of coral reefs. In particular, coral reefs in the Western Atlantic Province have undergone large-scale and consistent ecological changes during the last two decades. Few studi...
New tuberculosis technologies: challenges for retooling and scale-up.

PubMed

Pai, M; Palamountain, K M

2012-10-01

The availability of new tools does not mean that they will be adopted, used correctly, scaled up or have public health impact. Experience to date with new diagnostics suggests that many national tuberculosis programmes (NTPs) in high-burden countries are reluctant to adopt and scale up new tools, even when these are backed by evidence and global policy recommendations. We suggest that there are several common barriers to effective national adoption and scale-up of new technologies: global policy recommendations that do not provide sufficient information for scale-up, complex decision-making processes and weak political commitment at the country level, limited engagement of and support to NTP managers, high cost of tools and poor fit with user needs, unregulated markets and inadequate business models, limited capacity for laboratory strengthening and implementation research, and insufficient advocacy and donor support. Overcoming these barriers will require enhanced country-level advocacy, resources, technical assistance and political commitment. Some of the BRICS (Brazil, Russia, India, China, South Africa) countries are emerging as early adopters of policies and technologies, and are increasing their investments in TB control. They may provide the first opportunities to fully assess the public health impact of new tools.
Lower Limb Kinematics and Dynamic Postural Stability in Anterior Cruciate Ligament-Reconstructed Female Athletes

PubMed Central

Delahunt, Eamonn; Chawke, Mark; Kelleher, Judy; Murphy, Katie; Prendiville, Anna; Sweeny, Lauren; Patterson, Matt

2013-01-01

Context: Deficits in lower limb kinematics and postural stability are predisposing factors to the development of knee ligamentous injury. The extent to which these deficits are present after anterior cruciate ligament (ACL) reconstruction is still largely unknown. The primary hypothesis of the present study was that female athletes who have undergone ACL reconstruction and who have returned to sport participation would exhibit deficits in dynamic postural stability as well as deficiencies in hip- and knee-joint kinematics when compared with an age-, activity-, and sex-matched uninjured control group. Objective: To investigate dynamic postural stability as quantified by the Star Excursion Balance Test (SEBT) and simultaneous hip- and knee-joint kinematic profiles in female athletes who have undergone ACL reconstruction. Design: Descriptive laboratory study. Setting: University motion-analysis laboratory. Patients or Other Participants: Fourteen female athletes who had previously undergone ACL reconstruction (ACL-R) and 17 age- and sex-matched uninjured controls. Intervention(s): Each participant performed 3 trials of the anterior, posterior-medial, and posterior-lateral directional components of the SEBT. Main Outcome Measure(s): Reach distances for each directional component were quantified and expressed as a percentage of leg length. Simultaneous hip- and knee-joint kinematic profiles were recorded using a motion-analysis system. Results: The ACL-R group had decreased reach distances on the posterior-medial (P < .01) and posterior-lateral (P < .01) directional components of the SEBT. During performance of the directional components of the SEBT, ACL-R participants demonstrated altered hip-joint frontal-, sagittal-, and transverse-plane kinematic profiles (P < .05), as well as altered knee-joint sagittal-plane kinematic profiles (P < .05). Conclusions: Deficits in dynamic postural stability and concomitant altered hip- and knee-joint kinematics are present after ACL reconstruction and return to competitive activity. The extent to which these deficits influence potential future injury is worthy of investigation. PMID:23672381
[Security Management in Clinical Laboratory Departments and Facilities: Current Status and Issues].

PubMed

Ishida, Haku; Nakamura, Junji; Yoshida, Hiroshi; Koike, Masaru; Inoue, Yuji

2014-11-01

We conducted a questionnaire survey regarding the current activities for protecting patients' privacy and the security of information systems (IS) related to the clinical laboratory departments of university hospitals, certified training facilities for clinical laboratories, and general hospitals in Yamaguchi Prefecture. The response rate was 47% from 215 medical institutions, including three commercial clinical laboratory centers. The results showed that there were some differences in management activities among facilities with respect to continuing education, the documentation or regulation of operational management for paper records, electronic information, remaining samples, genetic testing, and laboratory information for secondary use. They were suggested to be caused by differences in functions between university and general hospitals, differences in the scale of hospitals, or whether or not hospitals have received accreditation or ISO 15189. Regarding the IS, although the majority of facilities had sufficiently employed the access control to IS, there was some room for improvement in the management of special cases such as VIPs and patients with HIV infection. Furthermore, there were issues regarding the login method for computers shared by multiple staff, the showing of the names of personnel in charge of reports, and the risks associated with direct connections to systems and the Internet and the use of portable media such as USB memory sticks. These results indicated that further efforts are necessary for each facility to continue self-assessment and make improvements.

Improving catchment scale water quality modelling with continuous high resolution monitoring of metals in runoff

NASA Astrophysics Data System (ADS)

Saari, Markus; Rossi, Pekka; Blomberg von der Geest, Kalle; Mäkinen, Ari; Postila, Heini; Marttila, Hannu

2017-04-01

High metal concentrations in natural waters is one of the key environmental and health problems globally. Continuous in-situ analysis of metals from runoff water is technically challenging but essential for the better understanding of processes which lead to pollutant transport. Currently, typical analytical methods for monitoring elements in liquids are off-line laboratory methods such as ICP-OES (Inductively Coupled Plasma Optical Emission Spectroscopy) and ICP-MS (ICP combined with a mass spectrometer). Disadvantage of the both techniques is time consuming sample collection, preparation, and off-line analysis at laboratory conditions. Thus use of these techniques lack possibility for real-time monitoring of element transport. We combined a novel high resolution on-line metal concentration monitoring with catchment scale physical hydrological modelling in Mustijoki river in Southern Finland in order to study dynamics of processes and form a predictive warning system for leaching of metals. A novel on-line measurement technique based on micro plasma emission spectroscopy (MPES) is tested for on-line detection of selected elements (e.g. Na, Mg, Al, K, Ca, Fe, Ni, Cu, Cd and Pb) in runoff waters. The preliminary results indicate that MPES can sufficiently detect and monitor metal concentrations from river water. Water and Soil Assessment Tool (SWAT) catchment scale model was further calibrated with high resolution metal concentration data. We show that by combining high resolution monitoring and catchment scale physical based modelling, further process studies and creation of early warning systems, for example to optimization of drinking water uptake from rivers, can be achieved.
Clinical privileges for laparoscopic surgery.

PubMed

Albrink, M H; Rosemurgy, A S

1993-06-01

Laparoscopic cholecystectomy has undergone an explosive growth. Its benefits to patients--shortened recovery time and less pain--became immediately obvious. The procedure's development and adaptation have largely been devised and implemented by ingenious and creative private practitioners, not the typical mode of introduction. Most or many new procedures in the past evolved from academic institutions after laboratory and then clinical trials. With rapid development and acceptance has come an additional new burden among medical practitioners: credentialing and granting clinical privileges.
Protecting the Green Behind the Gold: Catchment-Wide Restoration Efforts Necessary to Achieve Nutrient and Sediment Load Reduction Targets in Gold Coast City, Australia

NASA Astrophysics Data System (ADS)

Waltham, Nathan J.; Barry, Michael; McAlister, Tony; Weber, Tony; Groth, Dominic

2014-10-01

The Gold Coast City is the tourist center of Australia and has undergone rapid and massive urban expansion over the past few decades. The Broadwater estuary, in the heart of the City, not only offers an array of ecosystems services for many important aquatic wildlife species, but also supports the livelihood and lifestyles of residents. Not surprisingly, there have been signs of imbalance between these two major services. This study combined a waterway hydraulic and pollutant transport model to simulate diffuse nutrient and sediment loads under past and future proposed land-use changes. A series of catchment restoration initiatives were modeled in an attempt to define optimal catchment scale restoration efforts necessary to protect and enhance the City's waterways. The modeling revealed that for future proposed development, a business as usual approach to catchment management will not reduce nutrient and sediment loading sufficiently to protect the community values. Considerable restoration of upper catchment tributaries is imperative, combined with treatment of stormwater flow from intensively developed sub-catchment areas. Collectively, initiatives undertaken by regulatory authorities to date have successfully reduced nutrient and sediment loading reaching adjoining waterways, although these programs have been ad hoc without strategic systematic planning and vision. Future conservation requires integration of multidisciplinary science and proactive management driven by the high ecological, economical, and community values placed on the City's waterways. Long-term catchment restoration and conservation planning requires an extensive budget (including political and societal support) to handle ongoing maintenance issues associated with scale of restoration determined here.
Fat Plumes May Reflect the Complex Rheology of the Lower Mantle

NASA Astrophysics Data System (ADS)

Davaille, A.; Carrez, Ph.; Cordier, P.

2018-02-01

Recent tomographic imaging of the mantle below major hot spots shows slow seismic velocities extending down to the core-mantle boundary, confirming the existence of mantle plumes. However, these plumes are much thicker than previously thought. Using new laboratory experiments and scaling laws, we show that thermal plumes developing in a visco-plastic fluid present much larger diameters than plumes developing in a Newtonian fluid. Such a rheology requiring a yield stress is consistent with a lower mantle predominantly deforming by pure dislocation climb. Yield stress values between 1 and 10 MPa, implying dislocation densities between 108 and 1010 m-2, would be sufficient to reproduce the plumes morphology observed in tomographic images.
Multidetector computed tomography findings of central bronchopleural fistulas as sequelae of tuberculosis, chemo radiation and trauma: A report of three cases

PubMed Central

Yuksekkaya, Ruken; Ozturk, Banu; Celikyay, Fatih; Sade, Recep; Kupeli, Mustafa; Yeginsu, Ali

2013-01-01

A bronchopleural fistula (BPF) is defined as a direct pathway between the bronchial tree or lung parenchyma and the pleural space. Herein, we describe the clinical findings and imaging results of BPFs in three cases. The patients' medical histories revealed that the first had recurrent pulmonary tuberculosis, the second had small-cell lung cancer (SCLC) and had previously undergone chemoradiotherapy, and the third had trauma. Multidetector computed tomography (MDCT) showed clear communication between the airways and pleural spaces which was sufficient for a proper diagnosis without performing a bronchoscopy. PMID:26029624
Psychometrics and Its Discontents: An Historical Perspective on the Discourse of the Measurement Tradition

ERIC Educational Resources Information Center

Schoenherr, Jordan Richard; Hamstra, Stanley J.

2016-01-01

Psychometrics has recently undergone extensive criticism within the medical education literature. The use of quantitative measurement using psychometric instruments such as response scales is thought to emphasize a narrow range of relevant learner skills and competencies. Recent reviews and commentaries suggest that a paradigm shift might be…
How to Construct an Organizational Field: Empirical Educational Research in Germany, 1995-2015

ERIC Educational Resources Information Center

Zapp, Mike; Powell, Justin J. W.

2016-01-01

Over the past two decades, educational research in Germany has undergone unprecedented changes. Following large-scale assessments such as the Trends in International Mathematics and Science Study (TIMSS) and the Programme for International Student Assessment (PISA), and a political interest in evidence-based policy-making, quality assessment and…
Effects of white-nose syndrome on regional population patterns of 3 hibernating bat species

Treesearch

Thomas E. Ingersoll; Brent J. Sewall; Sybill K. Amelon

2016-01-01

Hibernating bats have undergone severe recent declines across the eastern United States, but the cause of these regional-scale declines has not been systematically evaluated. We assessed the influence of white-nose syndrome (an emerging bat disease caused by the fungus Pseudogymnoascus destructans, formerly Geomyces destructans...
Risk Factors for "Chlamydia Trachomatis" Infection in a California Collegiate Population

ERIC Educational Resources Information Center

Sipkin, Diane L.; Gillam, Alix; Grady, Laurie Bisset

2003-01-01

"Chlamydia trachomatis" infection in college students has not undergone a detailed large-scale evaluation. The authors undertook a cross-sectional study of 4,086 students enrolled on the campuses of California State University, Sacramento, and 3 local community colleges from fall 2000 through spring 2002. They used an outreach screening…
The recent breakup of an asteroid in the main-belt region.

PubMed

Nesvorný, David; Bottke, William F; Dones, Luke; Levison, Harold F

2002-06-13

The present population of asteroids in the main belt is largely the result of many past collisions. Ideally, the asteroid fragments resulting from each impact event could help us understand the large-scale collisions that shaped the planets during early epochs. Most known asteroid fragment families, however, are very old and have therefore undergone significant collisional and dynamical evolution since their formation. This evolution has masked the properties of the original collisions. Here we report the discovery of a family of asteroids that formed in a disruption event only 5.8 +/- 0.2 million years ago, and which has subsequently undergone little dynamical and collisional evolution. We identified 39 fragments, two of which are large and comparable in size (diameters of approximately 19 and approximately 14 km), with the remainder exhibiting a continuum of sizes in the range 2-7 km. The low measured ejection velocities suggest that gravitational re-accumulation after a collision may be a common feature of asteroid evolution. Moreover, these data can be used to check numerical models of larger-scale collisions.
Guided Inquiry in a Biochemistry Laboratory Course Improves Experimental Design Ability

ERIC Educational Resources Information Center

Goodey, Nina M.; Talgar, Cigdem P.

2016-01-01

Many biochemistry laboratory courses expose students to laboratory techniques through pre-determined experiments in which students follow stepwise protocols provided by the instructor. This approach fails to provide students with sufficient opportunities to practice experimental design and critical thinking. Ten inquiry modules were created for a…
A new multiscale approach for monitoring vegetation using remote sensing-based indicators in laboratory, field, and landscape.

PubMed

Lausch, Angela; Pause, Marion; Merbach, Ines; Zacharias, Steffen; Doktor, Daniel; Volk, Martin; Seppelt, Ralf

2013-02-01

Remote sensing is an important tool for studying patterns in surface processes on different spatiotemporal scales. However, differences in the spatiospectral and temporal resolution of remote sensing data as well as sensor-specific surveying characteristics very often hinder comparative analyses and effective up- and downscaling analyses. This paper presents a new methodical framework for combining hyperspectral remote sensing data on different spatial and temporal scales. We demonstrate the potential of using the "One Sensor at Different Scales" (OSADIS) approach for the laboratory (plot), field (local), and landscape (regional) scales. By implementing the OSADIS approach, we are able (1) to develop suitable stress-controlled vegetation indices for selected variables such as the Leaf Area Index (LAI), chlorophyll, photosynthesis, water content, nutrient content, etc. over a whole vegetation period. Focused laboratory monitoring can help to document additive and counteractive factors and processes of the vegetation and to correctly interpret their spectral response; (2) to transfer the models obtained to the landscape level; (3) to record imaging hyperspectral information on different spatial scales, achieving a true comparison of the structure and process results; (4) to minimize existing errors from geometrical, spectral, and temporal effects due to sensor- and time-specific differences; and (5) to carry out a realistic top- and downscaling by determining scale-dependent correction factors and transfer functions. The first results of OSADIS experiments are provided by controlled whole vegetation experiments on barley under water stress on the plot scale to model LAI using the vegetation indices Normalized Difference Vegetation Index (NDVI) and green NDVI (GNDVI). The regression model ascertained from imaging hyperspectral AISA-EAGLE/HAWK (DUAL) data was used to model LAI. This was done by using the vegetation index GNDVI with an R (2) of 0.83, which was transferred to airborne hyperspectral data on the local and regional scales. For this purpose, hyperspectral imagery was collected at three altitudes over a land cover gradient of 25 km within a timeframe of a few minutes, yielding a spatial resolution from 1 to 3 m. For all recorded spatial scales, both the LAI and the NDVI were determined. The spatial properties of LAI and NDVI of all recorded hyperspectral images were compared using semivariance metrics derived from the variogram. The first results show spatial differences in the heterogeneity of LAI and NDVI from 1 to 3 m with the recorded hyperspectral data. That means that differently recorded data on different scales might not sufficiently maintain the spatial properties of high spatial resolution hyperspectral images.
Uranium hydrogeochemical and stream sediment reconnaissance of the Philip Smith Mountains NTMS quadrangle, Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-09-01

Results of a hydrogeochemical and stream sediment reconnaissance of the Philip Smith Mountains NTMS quadrangle, Alaska are presented. In addition to this abbreviated data release, more complete data are available to the public in machine-readable form. In this data release are location data, field analyses, and laboratory analyses of several different sample media. For the sake of brevity, many field site observations have not been included in this volume. These data are, however, available on the magnetic tape. Appendices A and B describe the sample media and summarize the analytical results for each medium. The data were subsetted by onemore » of the Los Alamos National Laboratory (LANL) sorting programs into groups of stream sediment and lake sediment samples. For each group which contains a sufficient number of observations, statistical tables, tables of raw data, and 1:1000000 scale maps of pertinent elements have been included in this report.« less
Measuring Teaching Quality and Student Engagement in South Korea and The Netherlands

ERIC Educational Resources Information Center

van de Grift, Wim J. C. M.; Chun, Seyeoung; Maulana, Ridwan; Lee, Okhwa; Helms-Lorenz, Michelle

2017-01-01

Six observation scales for measuring the skills of teachers and 1 scale for measuring student engagement, assessed in South Korea and The Netherlands, are sufficiently reliable and offer sufficient predictive value for student engagement. A multigroup confirmatory factor analysis shows that the factor loadings and intercepts of the scales are the…
Preanalytical Errors in Hematology Laboratory- an Avoidable Incompetence.

PubMed

HarsimranKaur, Vikram Narang; Selhi, Pavneet Kaur; Sood, Neena; Singh, Aminder

2016-01-01

Quality assurance in the hematology laboratory is a must to ensure laboratory users of reliable test results with high degree of precision and accuracy. Even after so many advances in hematology laboratory practice, pre-analytical errors remain a challenge for practicing pathologists. This study was undertaken with an objective to evaluate the types and frequency of preanalytical errors in hematology laboratory of our center. All the samples received in the Hematology Laboratory of Dayanand Medical College and Hospital, Ludhiana, India over a period of one year (July 2013-July 2014) were included in the study and preanalytical variables like clotted samples, quantity not sufficient, wrong sample, without label, wrong label were studied. Of 471,006 samples received in the laboratory, preanalytical errors, as per the above mentioned categories was found in 1802 samples. The most common error was clotted samples (1332 samples, 0.28% of the total samples) followed by quantity not sufficient (328 sample, 0.06%), wrong sample (96 samples, 0.02%), without label (24 samples, 0.005%) and wrong label (22 samples, 0.005%). Preanalytical errors are frequent in laboratories and can be corrected by regular analysis of the variables involved. Rectification can be done by regular education of the staff.
SaDA: From Sampling to Data Analysis—An Extensible Open Source Infrastructure for Rapid, Robust and Automated Management and Analysis of Modern Ecological High-Throughput Microarray Data

PubMed Central

Singh, Kumar Saurabh; Thual, Dominique; Spurio, Roberto; Cannata, Nicola

2015-01-01

One of the most crucial characteristics of day-to-day laboratory information management is the collection, storage and retrieval of information about research subjects and environmental or biomedical samples. An efficient link between sample data and experimental results is absolutely important for the successful outcome of a collaborative project. Currently available software solutions are largely limited to large scale, expensive commercial Laboratory Information Management Systems (LIMS). Acquiring such LIMS indeed can bring laboratory information management to a higher level, but most of the times this requires a sufficient investment of money, time and technical efforts. There is a clear need for a light weighted open source system which can easily be managed on local servers and handled by individual researchers. Here we present a software named SaDA for storing, retrieving and analyzing data originated from microorganism monitoring experiments. SaDA is fully integrated in the management of environmental samples, oligonucleotide sequences, microarray data and the subsequent downstream analysis procedures. It is simple and generic software, and can be extended and customized for various environmental and biomedical studies. PMID:26047146
Cross-scale MD simulations of dynamic strength of tantalum

NASA Astrophysics Data System (ADS)

Bulatov, Vasily

2017-06-01

Dislocations are ubiquitous in metals where their motion presents the dominant and often the only mode of plastic response to straining. Over the last 25 years computational prediction of plastic response in metals has relied on Discrete Dislocation Dynamics (DDD) as the most fundamental method to account for collective dynamics of moving dislocations. Here we present first direct atomistic MD simulations of dislocation-mediated plasticity that are sufficiently large and long to compute plasticity response of single crystal tantalum while tracing the underlying dynamics of dislocations in all atomistic details. Where feasible, direct MD simulations sidestep DDD altogether thus reducing uncertainties of strength predictions to those of the interatomic potential. In the specific context of shock-induced material dynamics, the same MD models predict when, under what conditions and how dislocations interact and compete with other fundamental mechanisms of dynamic response, e.g. twinning, phase-transformations, fracture. In collaboration with: Luis Zepeda-Ruiz, Lawrence Livermore National Laboratory; Alexander Stukowski, Technische Universitat Darmstadt; Tomas Oppelstrup, Lawrence Livermore National Laboratory. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.
SaDA: From Sampling to Data Analysis-An Extensible Open Source Infrastructure for Rapid, Robust and Automated Management and Analysis of Modern Ecological High-Throughput Microarray Data.

PubMed

Singh, Kumar Saurabh; Thual, Dominique; Spurio, Roberto; Cannata, Nicola

2015-06-03

One of the most crucial characteristics of day-to-day laboratory information management is the collection, storage and retrieval of information about research subjects and environmental or biomedical samples. An efficient link between sample data and experimental results is absolutely important for the successful outcome of a collaborative project. Currently available software solutions are largely limited to large scale, expensive commercial Laboratory Information Management Systems (LIMS). Acquiring such LIMS indeed can bring laboratory information management to a higher level, but most of the times this requires a sufficient investment of money, time and technical efforts. There is a clear need for a light weighted open source system which can easily be managed on local servers and handled by individual researchers. Here we present a software named SaDA for storing, retrieving and analyzing data originated from microorganism monitoring experiments. SaDA is fully integrated in the management of environmental samples, oligonucleotide sequences, microarray data and the subsequent downstream analysis procedures. It is simple and generic software, and can be extended and customized for various environmental and biomedical studies.
The Information Needs of Women Who Have Undergone Breast Cancer Surgery in the West of Turkey.

PubMed

Findik, Ummu Yildiz

2017-09-01

This descriptive study aimed to evaluate the information needs of breast cancer patients who have undergone surgery, and the level to which those information needs are met in the west of Turkey. It was conducted in 55 women who had undergone surgical intervention between March 2013 and March 2014 in a university hospital in the west of Turkey. A personal information form and the Patient Information Needs Scale were used to gather data. Descriptive statistics, the Chi-square test, and the Wilcoxon signed-rank test were used to analyze the data. It was found that the information need of the patients (3.9 +/- 0.6) was near the "very important" level, and that this need was "somewhat met" (2.4 +/- 0.9). When the information needs of the patients and the level to which those needs were fulfilled were compared, the level of fulfillment was statistically significantly lower (p < 0.001). Among the different subscales evaluated, information relating to medication was the most needed, and the information needs pertaining to this subscale were met to a greater degree (p < 0.05) than the remaining subscales. The results showed that the information needs, primarily the medication-related information needs, of the patients were high, but that the level of meeting these needs was low. It should be considered important for patients who have undergone breast cancer surgery to be kept informed and provided with information regarding their medication.
RSRM Nozzle Anomalous Throat Erosion Investigation Overview

NASA Technical Reports Server (NTRS)

Clinton, R. G., Jr.; Wendel, Gary M.

1998-01-01

In September, 1996, anomalous pocketing erosion was observed in the aft end of the throat ring of the nozzle of one of the reusable solid rocket motors (RSRM 56B) used on NASA's space transportation system (STS) mission 79. The RSRM throat ring is constructed of bias tape-wrapped carbon cloth/ phenolic (CCP) ablative material. A comprehensive investigation revealed necessary and sufficient conditions for occurrence of the pocketing event and provided rationale that the solid rocket motors for the subsequent mission, STS-80, were safe to fly. The nozzles of both of these motors also exhibited anomalous erosion similar to, but less extensive than that observed on STS-79. Subsequent to this flight, the investigation to identify both the specific causes and the corrective actions for elimination of the necessary and sufficient conditions for the pocketing erosion was intensified. A detailed fault tree approach was utilized to examine potential material and process contributors to the anomalous performance. The investigation involved extensive constituent and component material property testing, pedigree assessments, supplier audits, process audits, full scale processing test article fabrication and evaluation, thermal and thermostructural analyses, nondestructive evaluation, and material performance tests conducted using hot fire simulation in laboratory test beds and subscale and full scale solid rocket motor static test firings. This presentation will provide an over-view of the observed anomalous nozzle erosion and the comprehensive, fault-tree based investigation conducted to resolve this issue.

Cold intolerance is not more common or disabling after digital replantation than after other treatment of compound digital injuries.

PubMed

Lithell, M; Backman, C; Nyström, A

1998-03-01

Cold intolerance is a common reason for disability after hand injury. In this study of posttraumatic cold intolerance, 20 patients with a history of digital replantation were matched with 20 control subjects who had not undergone replantation. The incidence and intensity of cold-related symptoms among patients in the two groups was investigated through the use of individual interviews and a grading scale for self-assessment of symptoms. The analysis of data indicates that although the pattern of symptoms may vary, the condition is neither more common nor more disabling among those who have undergone digital replantation. Cold intolerance after digital replantation seems, therefore, to be defined by the initial trauma and not by the subsequent reconstructive surgery.
Wakayama symposium: new therapies for modulation of epithelialization in corneal wound healing.

PubMed

Choi, Jun-Sub; Joo, Choun-Ki

2013-01-01

Many factors are involved in the corneal wound healing mechanism, including adhesion, migration, and proliferation of corneal epithelial cells. Abnormal corneal wound healing leads to corneal edema, neovascularization, scar formation, and poor vision. Three agents, 17β-estradiol, nicergoline, and β-glucan, have demonstrated positive effects on the wound healing response in laboratory experiments and may be of help in controlling wound healing in corneas that have suffered epithelial damage or have undergone refractive surgery. Copyright © 2013 Elsevier Inc. All rights reserved.
Lobe-cleft instability in the buoyant gravity current generated by estuarine outflow

NASA Astrophysics Data System (ADS)

Horner-Devine, Alexander R.; Chickadel, C. Chris

2017-05-01

Gravity currents represent a broad class of geophysical flows including turbidity currents, powder avalanches, pyroclastic flows, sea breeze fronts, haboobs, and river plumes. A defining feature in many gravity currents is the formation of three-dimensional lobes and clefts along the front and researchers have sought to understand these ubiquitous geophysical structures for decades. The prevailing explanation is based largely on early laboratory and numerical model experiments at much smaller scales, which concluded that lobes and clefts are generated due to hydrostatic instability exclusively in currents propagating over a nonslip boundary. Recent studies suggest that frontal dynamics change as the flow scale increases, but no measurements have been made that sufficiently resolve the flow structure in full-scale geophysical flows. Here we use thermal infrared and acoustic imaging of a river plume to reveal the three-dimensional structure of lobes and clefts formed in a geophysical gravity current front. The observed lobes and clefts are generated at the front in the absence of a nonslip boundary, contradicting the prevailing explanation. The observed flow structure is consistent with an alternative formation mechanism, which predicts that the lobe scale is inherited from subsurface vortex structures.
Generation of scaled protogalactic seed magnetic fields in laser-produced shock waves.

PubMed

Gregori, G; Ravasio, A; Murphy, C D; Schaar, K; Baird, A; Bell, A R; Benuzzi-Mounaix, A; Bingham, R; Constantin, C; Drake, R P; Edwards, M; Everson, E T; Gregory, C D; Kuramitsu, Y; Lau, W; Mithen, J; Niemann, C; Park, H-S; Remington, B A; Reville, B; Robinson, A P L; Ryutov, D D; Sakawa, Y; Yang, S; Woolsey, N C; Koenig, M; Miniati, F

2012-01-25

The standard model for the origin of galactic magnetic fields is through the amplification of seed fields via dynamo or turbulent processes to the level consistent with present observations. Although other mechanisms may also operate, currents from misaligned pressure and temperature gradients (the Biermann battery process) inevitably accompany the formation of galaxies in the absence of a primordial field. Driven by geometrical asymmetries in shocks associated with the collapse of protogalactic structures, the Biermann battery is believed to generate tiny seed fields to a level of about 10(-21) gauss (refs 7, 8). With the advent of high-power laser systems in the past two decades, a new area of research has opened in which, using simple scaling relations, astrophysical environments can effectively be reproduced in the laboratory. Here we report the results of an experiment that produced seed magnetic fields by the Biermann battery effect. We show that these results can be scaled to the intergalactic medium, where turbulence, acting on timescales of around 700 million years, can amplify the seed fields sufficiently to affect galaxy evolution.
Long-term negative impact on quality of life in patients with successfully treated Cushing's disease.

PubMed

Heald, Adrian H; Ghosh, Sandip; Bray, Stephanie; Gibson, Christine; Anderson, Simon G; Buckler, Helen; Fowler, Helen L

2004-10-01

A cohort of pituitary tumour patients, who had undergone definitive treatment within a 15-year period at a single neuroscience centre, were investigated as to whether there were differences in psychological well-being and psychosocial functioning, dependent on endocrine pathology and treatment variables. A detailed assessment of 114 patients with benign pituitary tumours in relation to primary diagnosis and mode of treatment was carried out. Psychological rating scales used were: the Hospital Anxiety and Depression Scale--UK version (HADS-UK), the World Health Organization Quality of Life Scale--abbreviated version (WHOQOL-BREF), General Health Questionnaire 28 (GHQ-28), the Functional Assessment of Cancer Therapy (FACT) and the Social Adjustment Scale--modified (SAS1 and SAS2; the former completed by the patient and the latter by another person who knows the patient well). All Cushing's patients were biochemically cured as defined by a normal 24-h urine free cortisol excretion within the previous 6 months. Patients with treated Cushing's disease had significantly impaired psychological well-being and psychosocial functioning across all tested domains compared with all other pituitary tumours, where scores were similar. When participants with Cushing's disease were excluded, patients who had undergone transfrontal surgery scored significantly higher on GHQ and HADS ratings than transsphenoidally treated patients. Cushing's disease even when biochemically stable has long-term adverse effects on mood and social functioning. We hypothesize that this may be related to irreversible changes in central neural function. Further studies are necessary to define the precise pathways involved.
Hawking-like radiation does not require a trapped region.

PubMed

Barceló, Carlos; Liberati, Stefano; Sonego, Sebastiano; Visser, Matt

2006-10-27

We discuss the issue of quasiparticle production by "analogue black holes" with particular attention paid to the possibility of reproducing Hawking radiation in a laboratory. By constructing simple geometric acoustic models, we obtain a somewhat unexpected result: We show that, in order to obtain a stationary and Planckian emission of quasiparticles, it is not necessary to create a trapped region in the acoustic spacetime (corresponding to a supersonic regime in the fluid flow). It is sufficient to set up a dynamically changing flow asymptotically approaching a sonic regime with sufficient rapidity in laboratory time. This result is generic to curved-space quantum field theory, the "analogue spacetimes" we consider providing a guide to physical intuition, and a possible route to laboratory experiments.
Characterization and scaling of anisotropy of fabrics and fractures at laboratory scales: insights from volumetric analysis using computed tomography

NASA Astrophysics Data System (ADS)

Ketcham, Richard A.

2017-04-01

Anisotropy in three-dimensional quantities such as geometric shape and orientation is commonly quantified using principal components analysis, in which a second order tensor determines the orientations of orthogonal components and their relative magnitudes. This approach has many advantages, such as simplicity and ability to accommodate many forms of data, and resilience to data sparsity. However, when data are sufficiently plentiful and precise, they sometimes show that aspects of the principal components approach are oversimplifications that may affect how the data are interpreted or extrapolated for mathematical or physical modeling. High-resolution X-ray computed tomography (CT) can effectively extract thousands of measurements from a single sample, providing a data density sufficient to examine the ways in which anisotropy on the hand-sample scale and smaller can be quantified, and the extent to which the ways the data are simplified are faithful to the underlying distributions. Features within CT data can be considered as discrete objects or continuum fabrics; the latter can be characterized using a variety of metrics, such as the most commonly used mean intercept length, and also the more specialized star length and star volume distributions. Each method posits a different scaling among components that affects the measured degree of anisotropy. The star volume distribution is the most sensitive to anisotropy, and commonly distinguishes strong fabric components that are not orthogonal. Although these data are well-presented using a stereoplot, 3D rose diagrams are another visualization option that can often help identify these components. This talk presents examples from a number of cases, starting with trabecular bone and extending to geological features such as fractures and brittle and ductile fabrics, in which non-orthogonal principal components identified using CT provide some insight into the origin of the underlying structures, and how they should be interpreted and potentially up-scaled.
The Effect of Degrees of Direction in the Qualitative Analysis Laboratory on Retention of Learning

ERIC Educational Resources Information Center

Holcomb, Charlie M.

1971-01-01

Students given sufficient information to be able to design chemical separations of cations performed better on a post-test, and on a four-month retention test on chemical knowledge and laboratory procedures, than students given a detailed laboratory guide listing the steps to follow. (AL)
Psychological impact of female genital mutilation among adolescent Egyptian girls: a cross-sectional study.

PubMed

Ahmed, Magdy R; Shaaban, Mohamed M; Meky, Heba K; Amin Arafa, Mohamed E; Mohamed, Tamer Y; Gharib, Waleed F; Ahmed, Abeer B

2017-08-01

Worldwide, at least 200 million women and girls have undergone female genital mutilation (FGM). The medical and sexual consequences have been documented, but the psychological impact has not been studied to the same extent. The aim of this study was to explore the relationship between FGM and psychiatric problems among adolescent girls. A total of 204 girls, aged 14-19 years, were included in a cross-sectional study conducted at Suez Canal University Hospitals. All participants completed an Arabic-validated, structured questionnaire covering nine symptom scales. Sociodemographic data were also collected. Main outcome measures were the prevalence of psychiatric problems among adolescent girls who had undergone FGM. Overall, 66.2% of girls had undergone FGM. The percentage in rural areas was 91.8%, compared with 43.0% in urban areas. There were no significant differences between the FGM and non-FGM groups as regards religion, educational and socioeconomic levels. FGM girls had a significantly higher level of psychological problems with regard to somatisation, depression, anxiety, phobic anxiety and hostility compared with non-FGM girls (p < .0001). FGM is a traumatic experience that may leave a lasting psychological mark and a negative impact on the psychological status of affected girls.
On the physical association of the peculiar emission: Line stars HD 122669 and HD 122691

NASA Technical Reports Server (NTRS)

Garrison, R. F.; Hiltner, W. A.; Sanduleak, N.

1975-01-01

Spectroscopic and photometric observations indicate a physical association between the peculiar early-type emission-line stars HD 122669 and HD 122691. The latter has undergone a drastic change in the strength of its emission lines during the past twenty years. There is some indication that both stars vary with shorter time scales.
School Improvements in Abu Dhabi, United Arab Emirates: Asking the "Expert Witnesses"

ERIC Educational Resources Information Center

Dickson, Martina

2013-01-01

Government schools in Abu Dhabi, as part of wide-scale educational reforms undertaken in the whole of the United Arab Emirates, have undergone massive school improvement developments over the past seven years. Over the course of these years, the reality of student life for those in government schools has been widely altered. This research explores…
“Modeling Trends in Air Pollutant Concentrations over the ...

EPA Pesticide Factsheets

Regional model calculations over annual cycles have pointed to the need for accurately representing impacts of long-range transport. Linking regional and global scale models have met with mixed success as biases in the global model can propagate and influence regional calculations and often confound interpretation of model results. Since transport is efficient in the free-troposphere and since simulations over Continental scales and annual cycles provide sufficient opportunity for “atmospheric turn-over”, i.e., exchange between the free-troposphere and the boundary-layer, a conceptual framework is needed wherein interactions between processes occurring at various spatial and temporal scales can be consistently examined. The coupled WRF-CMAQ model is expanded to hemispheric scales and model simulations over period spanning 1990-current are analyzed to examine changes in hemispheric air pollution resulting from changes in emissions over this period. The National Exposure Research Laboratory (NERL) Atmospheric Modeling and Analysis Division (AMAD) conducts research in support of EPA mission to protect human health and the environment. AMAD research program is engaged in developing and evaluating predictive atmospheric models on all spatial and temporal scales for forecasting the air quality and for assessing changes in air quality and air pollutant exposures, as affected by changes in ecosystem management and regulatory decisions. AMAD is responsible for pr
Preparing Laboratory and Real-World EEG Data for Large-Scale Analysis: A Containerized Approach

PubMed Central

Bigdely-Shamlo, Nima; Makeig, Scott; Robbins, Kay A.

2016-01-01

Large-scale analysis of EEG and other physiological measures promises new insights into brain processes and more accurate and robust brain–computer interface models. However, the absence of standardized vocabularies for annotating events in a machine understandable manner, the welter of collection-specific data organizations, the difficulty in moving data across processing platforms, and the unavailability of agreed-upon standards for preprocessing have prevented large-scale analyses of EEG. Here we describe a “containerized” approach and freely available tools we have developed to facilitate the process of annotating, packaging, and preprocessing EEG data collections to enable data sharing, archiving, large-scale machine learning/data mining and (meta-)analysis. The EEG Study Schema (ESS) comprises three data “Levels,” each with its own XML-document schema and file/folder convention, plus a standardized (PREP) pipeline to move raw (Data Level 1) data to a basic preprocessed state (Data Level 2) suitable for application of a large class of EEG analysis methods. Researchers can ship a study as a single unit and operate on its data using a standardized interface. ESS does not require a central database and provides all the metadata data necessary to execute a wide variety of EEG processing pipelines. The primary focus of ESS is automated in-depth analysis and meta-analysis EEG studies. However, ESS can also encapsulate meta-information for the other modalities such as eye tracking, that are increasingly used in both laboratory and real-world neuroimaging. ESS schema and tools are freely available at www.eegstudy.org and a central catalog of over 850 GB of existing data in ESS format is available at studycatalog.org. These tools and resources are part of a larger effort to enable data sharing at sufficient scale for researchers to engage in truly large-scale EEG analysis and data mining (BigEEG.org). PMID:27014048
Passive seismic monitoring of natural and induced earthquakes: case studies, future directions and socio-economic relevance

USGS Publications Warehouse

Bohnhoff, Marco; Dresen, Georg; Ellsworth, William L.; Ito, Hisao; Cloetingh, Sierd; Negendank, Jörg

2010-01-01

An important discovery in crustal mechanics has been that the Earth’s crust is commonly stressed close to failure, even in tectonically quiet areas. As a result, small natural or man-made perturbations to the local stress field may trigger earthquakes. To understand these processes, Passive Seismic Monitoring (PSM) with seismometer arrays is a widely used technique that has been successfully applied to study seismicity at different magnitude levels ranging from acoustic emissions generated in the laboratory under controlled conditions, to seismicity induced by hydraulic stimulations in geological reservoirs, and up to great earthquakes occurring along plate boundaries. In all these environments the appropriate deployment of seismic sensors, i.e., directly on the rock sample, at the earth’s surface or in boreholes close to the seismic sources allows for the detection and location of brittle failure processes at sufficiently low magnitude-detection threshold and with adequate spatial resolution for further analysis. One principal aim is to develop an improved understanding of the physical processes occurring at the seismic source and their relationship to the host geologic environment. In this paper we review selected case studies and future directions of PSM efforts across a wide range of scales and environments. These include induced failure within small rock samples, hydrocarbon reservoirs, and natural seismicity at convergent and transform plate boundaries. Each example represents a milestone with regard to bridging the gap between laboratory-scale experiments under controlled boundary conditions and large-scale field studies. The common motivation for all studies is to refine the understanding of how earthquakes nucleate, how they proceed and how they interact in space and time. This is of special relevance at the larger end of the magnitude scale, i.e., for large devastating earthquakes due to their severe socio-economic impact.
Color-televised medical microscopy

NASA Technical Reports Server (NTRS)

Heath, M. A.; Peck, J. C.

1968-01-01

Color television microscopy used at laboratory range magnifications, reproduces a slide image with sufficient fidelity for medical laboratory and instructional use. The system is used for instant pathological reporting between operating room and remotely located pathologist viewing a biopsy through this medium.
Acoustic Scattering Models of Zooplankton and Microstructure

DTIC Science & Technology

1997-09-30

shelled (gastropods), and gas-bearing ( siphonophores )). 5) LABORATORY EXPERIMENTATION: ZOOPLANKTON. An extensive set of laboratory measurements on the...zooplankton ( siphonophores and pteropods) that have high enough target strengths and occur in sufficiently high numbers that they could interfere with
Granule size control and targeting in pulsed spray fluid bed granulation.

PubMed

Ehlers, Henrik; Liu, Anchang; Räikkönen, Heikki; Hatara, Juha; Antikainen, Osmo; Airaksinen, Sari; Heinämäki, Jyrki; Lou, Honxiang; Yliruusi, Jouko

2009-07-30

The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. One duty cycle consists of one on- and off-period. The study was performed with a laboratory-scale top-spray fluid bed granulator with duty cycle length and atomization pressure as studied variables. The liquid feed rate, amount and inlet air temperature were constant. The granules were small, indicating that the powder has only undergone ordered mixing, nucleation and early growth. The effect of atomizing pressure on granule size depends on inlet air relative humidity, with premature binder evaporation as a reason. The duty cycle length was of critical importance to the end product attributes, by defining the extent of intermittent drying and rewetting. By varying only the duty cycle length, it was possible to control granule nucleation and growth, with a wider granule size target range in increased relative humidity. The present study confirms that pulsed liquid feed in fluid bed granulation is a useful tool in end product particle size targeting.
Bioreactor Scalability: Laboratory-Scale Bioreactor Design Influences Performance, Ecology, and Community Physiology in Expanded Granular Sludge Bed Bioreactors

PubMed Central

Connelly, Stephanie; Shin, Seung G.; Dillon, Robert J.; Ijaz, Umer Z.; Quince, Christopher; Sloan, William T.; Collins, Gavin

2017-01-01

Studies investigating the feasibility of new, or improved, biotechnologies, such as wastewater treatment digesters, inevitably start with laboratory-scale trials. However, it is rarely determined whether laboratory-scale results reflect full-scale performance or microbial ecology. The Expanded Granular Sludge Bed (EGSB) bioreactor, which is a high-rate anaerobic digester configuration, was used as a model to address that knowledge gap in this study. Two laboratory-scale idealizations of the EGSB—a one-dimensional and a three- dimensional scale-down of a full-scale design—were built and operated in triplicate under near-identical conditions to a full-scale EGSB. The laboratory-scale bioreactors were seeded using biomass obtained from the full-scale bioreactor, and, spent water from the distillation of whisky from maize was applied as substrate at both scales. Over 70 days, bioreactor performance, microbial ecology, and microbial community physiology were monitored at various depths in the sludge-beds using 16S rRNA gene sequencing (V4 region), specific methanogenic activity (SMA) assays, and a range of physical and chemical monitoring methods. SMA assays indicated dominance of the hydrogenotrophic pathway at full-scale whilst a more balanced activity profile developed during the laboratory-scale trials. At each scale, Methanobacterium was the dominant methanogenic genus present. Bioreactor performance overall was better at laboratory-scale than full-scale. We observed that bioreactor design at laboratory-scale significantly influenced spatial distribution of microbial community physiology and taxonomy in the bioreactor sludge-bed, with 1-D bioreactor types promoting stratification of each. In the 1-D laboratory bioreactors, increased abundance of Firmicutes was associated with both granule position in the sludge bed and increased activity against acetate and ethanol as substrates. We further observed that stratification in the sludge-bed in 1-D laboratory-scale bioreactors was associated with increased richness in the underlying microbial community at species (OTU) level and improved overall performance. PMID:28507535
Analysis of electromagnetic fields on an F-106B aircraft during lightning strikes

NASA Technical Reports Server (NTRS)

Trost, T. F.; Pitts, F. L.

1982-01-01

Information on the exterior electromagnetic environment of an aircraft when it is struck by lightning has been obtained during thunderstorm penetrations with an F-106B aircraft. Electric and magnetic fields were observed, using mainly time-derivative type sensors, with bandwidths to 50 MHz. Lightning pulse lengths ranging from 25 ns to 7 microsec have been recorded. Sufficient high-frequency content was present to excite electromagnetic resonances of the aircraft, and peaks in the frequency spectra of the waveforms in the range 7 to 23 MHz are in agreement with the resonant frequencies determined in laboratory scale-model tests. Both positively and negatively charged strikes were experienced, and most of the data suggest low values of peak current.
Estimating Bias Error Distributions

NASA Technical Reports Server (NTRS)

Liu, Tian-Shu; Finley, Tom D.

2001-01-01

This paper formulates the general methodology for estimating the bias error distribution of a device in a measuring domain from less accurate measurements when a minimal number of standard values (typically two values) are available. A new perspective is that the bias error distribution can be found as a solution of an intrinsic functional equation in a domain. Based on this theory, the scaling- and translation-based methods for determining the bias error distribution arc developed. These methods are virtually applicable to any device as long as the bias error distribution of the device can be sufficiently described by a power series (a polynomial) or a Fourier series in a domain. These methods have been validated through computational simulations and laboratory calibration experiments for a number of different devices.

The history of imitation in learning theory: the language acquisition process.

PubMed Central

Kymissis, E; Poulson, C L

1990-01-01

The concept of imitation has undergone different analyses in the hands of different learning theorists throughout the history of psychology. From Thorndike's connectionism to Pavlov's classical conditioning, Hull's monistic theory, Mowrer's two-factor theory, and Skinner's operant theory, there have been several divergent accounts of the conditions that produce imitation and the conditions under which imitation itself may facilitate language acquisition. In tracing the roots of the concept of imitation in the history of learning theory, the authors conclude that generalized imitation, as defined and analyzed by operant learning theorists, is a sufficiently robust formulation of learned imitation to facilitate a behavior-analytic account of first-language acquisition. PMID:2230633
Method for in-situ restoration of plantinum resistance thermometer calibration

DOEpatents

Carroll, Radford M.

1989-01-01

A method is provided for in-situ restoration of platinum resistance thermometers (PRT's) that have undergone surface oxide contamination and/or strain-related damage causing decalibration. The method, which may be automated using a programmed computer control arrangement, consists of applying a dc heating current to the resistive sensing element of the PRT of sufficient magnitude to heat the element to an annealing temperature and maintaining the temperature for a specified period to restore the element to a stress-free calibration condition. The process anneals the sensing element of the PRT without subjecting the entire PRT assembly to the annealing temperature and may be used in the periodic maintenance of installed PRT's.
Method for in-situ restoration of platinum resistance thermometer calibration

DOEpatents

Carroll, R.M.

1987-10-23

A method is provided for in-situ restoration of platinum resistance thermometers (PRT's) that have undergone surface oxide contamination and/or stain-related damage causing decalibration. The method, which may be automated using a programmed computer control arrangement, consists of applying a dc heating current to the resistive sensing element of the PRT of sufficient magnitude to heat the element to an annealing temperature and maintaining the temperature for a specified period to restore the element to a stress-free calibration condition. The process anneals the sensing element of the PRT without subjecting the entire PRT assembly to the annealing temperature and may be used in the periodic maintenance of installed PRT's. 1 fig.
Tuberculosis screening prior to anti-tumor necrosis factor therapy among patients with immune-mediated inflammatory diseases in Japan: a longitudinal study using a large-scale health insurance claims database.

PubMed

Tomio, Jun; Yamana, Hayato; Matsui, Hiroki; Yamashita, Hiroyuki; Yoshiyama, Takashi; Yasunaga, Hideo

2017-11-01

Tuberculosis screening is recommended for patients with immune-mediated inflammatory diseases (IMIDs) prior to anti-tumor necrosis factor (TNF) therapy. However, adherence to the recommended practice is unknown in the current clinical setting in Japan. We used a large-scale health insurance claims database in Japan to conduct a longitudinal observational study. Of more than two million beneficiaries in the database between 2013 and 2014, we enrolled those with IMIDs aged 15-69 years who had initiated anti-TNF therapy. We defined tuberculosis screening primarily as tuberculin skin test and/or interferon-gamma release assay (TST/IGRA) within 2 months before commencing anti-TNF therapy. We analyzed the proportions of the patients who had undergone tuberculosis screening and the associations with primary disease, type of anti-TNF agent, methotrexate prescription prior to anti-TNF therapy, and treatment for latent tuberculosis infection (LTBI). Of 385 patients presumed to have initiated anti-TNF therapy, 252 (66%) had undergone tuberculosis screening by TST/IGRA (22% TST, 56% IGRA, and 12% both TST and IGRA), and 231 (60%) had undergone TST/IGRA and radiography. Patients with psoriasis tended to be more likely to undergo tuberculosis screening than those with other diseases; however, this association was not statistically significant. Treatment for LTBI was provided to 43 (11%) patients; 123 (32%) received neither TST/IGRA nor LTBI treatment. Tuberculosis screening was often not performed prior to anti-TNF therapy despite the guidelines' recommendations; thus, patients could be put at unnecessary risk of reactivation of tuberculosis. © 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
Lithospheric extension near Lake Mead, Nevada - A model for ductile flow in the lower crust

NASA Technical Reports Server (NTRS)

Kruse, Sarah; Mcnutt, Marcia; Phipps-Morgan, Jason; Royden, Leigh

1991-01-01

Small variations in gravity anomalies and topographic elevation observed in areas that have undergone highly variable amounts of upper crustal thinning can be satisfactorily explained by ductile flow of lower crustal material under the proper conditions. The boundary between the unextended Colorado Plateau and a strongly extended domain in the Basin and Range Province in the Lake Mead (Nevada) region is examined. Finite element modeling of Newtonian flow and power law creep shows that flow over the length scale of the eastern Basin and Range (500) km or more) corresponding to upper crustal extension by a factor of 1.4-3 over 10 million years requires effective viscosities less than 10 to the 18th - 10 to the 20th Pa s for ductile channels 10-25 km thick. Modeling suggests that these effective viscosities may be sustained by lower crustal material deforming at laboratory-derived power law creep rates. The longer-scale flow may require elevated crustal temperatures (more than 700 C), depending on the composition and material properties assumed. Under the boundary conditions assumed in this study the linear viscous flow models yield a satisfactory approximation to deformation by power law creep. This work suggests that flow in the lower crust may be a viable mechanism for producing small variations in total crustal thickness between strongly extended and less extended regions, and thereby explaining the relative uniformity in gravity and topography between such regions.
Microfluidics for producing poly (lactic-co-glycolic acid)-based pharmaceutical nanoparticles.

PubMed

Li, Xuanyu; Jiang, Xingyu

2017-12-24

Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods. The batch-to-batch reproducibility which is essential for clinical translation is achieved by precisely controlling the precursors and the flow rate, regardless of operators. Poly (lactic-co-glycolic acid) (PLGA) is the most widely used Food and Drug Administration (FDA)-approved biodegradable polymers. Researchers often combine PLGA with lipids or amphiphilic molecules to assemble into a core/shell structure to exploit the potential of PLGA-based NPs as powerful carriers for cancer-related drug delivery. In this review, we discuss the advantages associated with microfluidic chips for producing PLGA-based functional nanocomplexes for drug delivery. These laboratory-based methods can readily scale up to provide sufficient amount of PLGA-based NPs in microfluidic chips for clinical studies and industrial-scale production. Copyright © 2017. Published by Elsevier B.V.
The USDA Feed the Future Initiative for genetic improvement of African goats: an update on genomic resources and genetic characterization of indigenous breeds

USDA-ARS?s Scientific Manuscript database

Food production systems in Africa depend heavily on the use of locally adapted animals such as goats which are critical to small-scale farmers as they are easier to acquire, maintain, and act as scavengers in sparse pasture and marginal crop regions. Indigenous goat ecotypes have undergone generatio...
Ecosystem stressors in southern Nevada [Chapter 2] (Executive Summary)

Treesearch

Burton K. Pendleton; Jeanne C. Chambers; Matthew L. Brooks; Steven M. Ostoja

2013-01-01

Southern Nevada ecosystems are subject to a number of stressors that range in scope from local to regional to global. At the regional scale, human population growth and related activities constitute a major stressor. Nevada has undergone significant change due to unprecedented population growth and ongoing global change processes. Nevadaâs growth rate has been the...
The challenge of transferring an implementation strategy from academia to the field: a process evaluation of local quality improvement collaboratives in Dutch primary care using the normalization process theory.

PubMed

Trietsch, Jasper; van Steenkiste, Ben; Hobma, Sjoerd; Frericks, Arnoud; Grol, Richard; Metsemakers, Job; van der Weijden, Trudy

2014-12-01

A quality improvement strategy consisting of comparative feedback and peer review embedded in available local quality improvement collaboratives proved to be effective in changing the test-ordering behaviour of general practitioners. However, implementing this strategy was problematic. We aimed for large-scale implementation of an adapted strategy covering both test ordering and prescribing performance. Because we failed to achieve large-scale implementation, the aim of this study was to describe and analyse the challenges of the transferring process. In a qualitative study 19 regional health officers, pharmacists, laboratory specialists and general practitioners were interviewed within 6 months after the transfer period. The interviews were audiotaped, transcribed and independently coded by two of the authors. The codes were matched to the dimensions of the normalization process theory. The general idea of the strategy was widely supported, but generating the feedback was more complex than expected and the need for external support after transfer of the strategy remained high because participants did not assume responsibility for the work and the distribution of resources that came with it. Evidence on effectiveness, a national infrastructure for these collaboratives and a general positive attitude were not sufficient for normalization. Thinking about managing large databases, responsibility for tasks and distribution of resources should start as early as possible when planning complex quality improvement strategies. Merely exploring the barriers and facilitators experienced in a preceding trial is not sufficient. Although multifaceted implementation strategies to change professional behaviour are attractive, their inherent complexity is also a pitfall for large-scale implementation. © 2014 John Wiley & Sons, Ltd.
Biotransformation of trace organic chemicals during groundwater recharge: How useful are first-order rate constants?

PubMed

Regnery, J; Wing, A D; Alidina, M; Drewes, J E

2015-08-01

This study developed relationships between the attenuation of emerging trace organic chemicals (TOrC) during managed aquifer recharge (MAR) as a function of retention time, system characteristics, and operating conditions using controlled laboratory-scale soil column experiments simulating MAR. The results revealed that MAR performance in terms of TOrC attenuation is primarily determined by key environmental parameters (i.e., redox, primary substrate). Soil columns with suboxic and anoxic conditions performed poorly (i.e., less than 30% attenuation of moderately degradable TOrC) in comparison to oxic conditions (on average between 70-100% attenuation for the same compounds) within a residence time of three days. Given this dependency on redox conditions, it was investigated if key parameter-dependent rate constants are more suitable for contaminant transport modeling to properly capture the dynamic TOrC attenuation under field-scale conditions. Laboratory-derived first-order removal kinetics were determined for 19 TOrC under three different redox conditions and rate constants were applied to MAR field data. Our findings suggest that simplified first-order rate constants will most likely not provide any meaningful results if the target compounds exhibit redox dependent biotransformation behavior or if the intention is to exactly capture the decline in concentration over time and distance at field-scale MAR. However, if the intention is to calculate the percent removal after an extended time period and subsurface travel distance, simplified first-order rate constants seem to be sufficient to provide a first estimate on TOrC attenuation during MAR. Copyright © 2015 Elsevier B.V. All rights reserved.
Seasonal controls of the short term variability of pCO2 at the Scotian Shelf

NASA Astrophysics Data System (ADS)

Thomas, H.; Craig, S.; Greenan, B. J. W.; Burt, W.; Herndl, G. J.; Higginson, S.; Salt, L.; Shadwick, E. H.; Urrego-Blanco, J.

2012-04-01

Much of the surface ocean carbon cycle variability can be attributed to the availability of sunlight, through processes such as heat fluxes or photosynthesis, which regulate the ocean carbon cycle over a wide range of time scales. The critical processes occurring on timescales of a day or less, however, have undergone few investigations, and most of those have been limited to a time span of several days to months, or exceptionally, for longer periods. Optical methods have helped to infer short-term biological variability, however lacking corresponding investigations of oceanic CO2 system. Here, we employ high-frequency CO2 system and optical observations covering the full seasonal cycle on the Scotian Shelf, Northwestern Atlantic Ocean, in order to unravel daily periodicity of the surface ocean carbon cycle and its effects on annual budgets. We show that significant daily periodicity occurs only if the water column is sufficiently stable as observed during seasonal warming. During that time biological CO2 drawdown, or net community production (NCP), is delayed for several hours relative to the daylight cycle due the daily build-up of essential Chlorophyll a, to cell physiology and to grazing effects, all restricting or hindering photosynthesis in the early morning hours. NCP collapses in summer by more than 90%, when the mixed layer depth reaches the seasonal minimum, which eventually makes the observed daily periodicity of the CO2 system vanish.
A large scale laboratory cage trial of Aedes densonucleosis virus (AeDNV).

PubMed

Wise de Valdez, Megan R; Suchman, Erica L; Carlson, Jonathan O; Black, William C

2010-05-01

Aedes aegypti (L.) (Diptera: Culicidae) the primary vector of dengue viruses (DENV1-4), oviposit in and around human dwellings, including sites difficult to locate, making control of this mosquito challenging. We explored the efficacy and sustainability of Aedes Densonucleosis Virus (AeDNV) as a biocontrol agent for Ae. aegypti in and among oviposition sites in large laboratory cages (> 92 m3) as a prelude to field trials. Select cages were seeded with AeDNV in a single oviposition site (OPS) with unseeded OPSs established at varied distances. Quantitative real-time polymerase chain reaction was used to track dispersal and accumulation of AeDNV among OPSs. All eggs were collected weekly from each cage and counted. We asked: (1) Is AeDNV dispersed over varying distances and can it accumulate and persist in novel OPSs? (2) Are egg densities reduced in AeDNV treated populations? AeDNV was dispersed to and sustained in novel OPSs. Virus accumulation in OPSs was positively correlated with egg densities and proximity to the initial infection source affected the timing of dispersal and maintenance of viral titers. AeDNV did not significantly reduce Ae. aegypti egg densities. The current study documents that adult female Ae. aegypti oviposition behavior leads to successful viral dispersal from treated to novel containers in large-scale cages; however, the AeDNV titers reached were not sufficient to reduce egg densities.
PEE POWER® urinal II - Urinal scale-up with microbial fuel cell scale-down for improved lighting

NASA Astrophysics Data System (ADS)

Walter, Xavier Alexis; Merino-Jiménez, Irene; Greenman, John; Ieropoulos, Ioannis

2018-07-01

A novel design of microbial fuel cells (MFC) fuelled with undiluted urine was demonstrated to be an efficient power source for decentralised areas, but had only been tested under controlled laboratory conditions. Hence, a field-trial was carried out to assess its feasibility for practical implementation: a bespoke stack of 12 MFC modules was implemented as a self-sufficient lit urinal system at UK's largest music festival. Laboratory investigation showed that with a hydraulic retention time (HRT) of 44 h, a cascade of 4 modules (19.2 L displacement volume) was continuously producing ≈150 mW. At the same HRT, the chemical oxygen demand (COD) was reduced from 5586 mg COD·L-1 to 625 mg COD·L-1. Field results of the system under uncontrolled usage indicate an optimal retention time for power production between 2h30 and ≈9 h. When measured (HRT of ≈11h40), the COD decreased by 48% and the total nitrogen content by 13%. Compared to the previous PEE POWER® field-trial (2015), the present system achieved a 37% higher COD removal with half the HRT. The 2016 set-up produced ≈30% more energy in a third of the total volumetric footprint (max 600 mW). This performance corresponds to ≈7-fold technological improvement.
Cohort profile: the Western Australian Sleep Health Study.

PubMed

Mukherjee, Sutapa; Hillman, David; Lee, Jessica; Fedson, Annette; Simpson, Laila; Ward, Kim; Love, Gregory; Edwards, Cass; Szegner, Bernadett; Palmer, Lyle John

2012-03-01

Epidemiologic and genetic studies of obstructive sleep apnoea (OSA) are limited by a lack of large-scale, well-characterized OSA cohorts. These studies require large sample size to provide adequate power to detect differences between groups. This study describes the development of such a cohort (The Western Australian Sleep Health Study) in OSA patients of Caucasian-European origin attending the only public sleep clinic in Western Australia (WA). The main aim of the study is to phenotype 4,000 OSA patients in order to define the genetics of OSA and its co-morbidities. Almost all underwent laboratory-based attended polysomnography (PSG). Currently complete data (questionnaire, biochemistry, DNA, and PSG) has been obtained on over 3,000 individuals and will reach the target of 4,000 individuals by the end of 2010. In a separate but related study, we have developed a sleep study database containing data from all patients who have undergone PSG at the sleep laboratory since its inception in 1988 until the present day (over 30,000 PSG studies representing data from approximately 20,000 individuals). In addition, data from both cohorts have been linked prospectively to statutory health data collected by the WA Department of Health. This study will be the largest sleep clinic cohort database internationally with access to genetic and epidemiological data. It is unique among sleep clinic cohorts because of its size, the breadth of data collected and the ability to link prospectively to statutory health data. It will be a major tool to comprehensively assess genetic and epidemiologic factors determining OSA and its co-morbidities.
The changing face of clinical laboratories.

PubMed

Plebani, M

1999-07-01

Laboratory medicine has undergone a sea change, and medical laboratories must now adapt to, and meet new, customer-supplier needs springing from shifts in the patterns of disease prevalence, medical practice, and demographics. Managed care and other cost-containment processes have forced those involved in health care to cooperate to develop a full picture of patient care, and this has affected clinical laboratory objectives, the main focus now being on improvement in medical outcomes. More recently, the resource shortages in health care and results of cost/effectiveness analysis have demonstrated that the value of a laboratory test must be ascertained not only on the basis of its chemical or clinical performance characteristics, but also by its impact on patient management, the only true assessment of the quality of testing being quality of patient outcomes. The time is ripe for changing the vision of laboratory medicine, and some of the reasons for this are the availability of results in real-time, the introduction of more specific tests, and the trend to prevent diseases rather than cure them. The information from laboratory tests designed to evaluate biochemical or genetic risk and/or prognostic factors cannot be replaced either by physical examination and/or the assessment of symptoms. Today, the importance of laboratory scientists must be proven in three broad areas: a) guaranteeing the quality of tests, irrespective of where they are performed; b) improving the quality of the service; c) maximizing the impact of laboratory information on patient management.
Dynamics of West Nile virus evolution in mosquito vectors.

PubMed

Grubaugh, Nathan D; Ebel, Gregory D

2016-12-01

West Nile virus remains the most common cause of arboviral encephalitis in North America. Since it was introduced, it has undergone adaptive genetic change as it spread throughout the continent. The WNV transmission cycle is relatively tractable in the laboratory. Thus the virus serves as a convenient model system for studying the population biology of mosquito-borne flaviviruses as they undergo transmission to and from mosquitoes and vertebrates. This review summarizes the current knowledge regarding the population dynamics of this virus within mosquito vectors. Copyright Â© 2016 Elsevier B.V. All rights reserved.
Magnetic Fields Recorded by Chondrules Formed in Nebular Shocks

NASA Astrophysics Data System (ADS)

Mai, Chuhong; Desch, Steven J.; Boley, Aaron C.; Weiss, Benjamin P.

2018-04-01

Recent laboratory efforts have constrained the remanent magnetizations of chondrules and the magnetic field strengths to which the chondrules were exposed as they cooled below their Curie points. An outstanding question is whether the inferred paleofields represent the background magnetic field of the solar nebula or were unique to the chondrule-forming environment. We investigate the amplification of the magnetic field above background values for two proposed chondrule formation mechanisms, large-scale nebular shocks and planetary bow shocks. Behind large-scale shocks, the magnetic field parallel to the shock front is amplified by factors of ∼10–30, regardless of the magnetic diffusivity. Therefore, chondrules melted in these shocks probably recorded an amplified magnetic field. Behind planetary bow shocks, the field amplification is sensitive to the magnetic diffusivity. We compute the gas properties behind a bow shock around a 3000 km radius planetary embryo, with and without atmospheres, using hydrodynamics models. We calculate the ionization state of the hot, shocked gas, including thermionic emission from dust, thermal ionization of gas-phase potassium atoms, and the magnetic diffusivity due to Ohmic dissipation and ambipolar diffusion. We find that the diffusivity is sufficiently large that magnetic fields have already relaxed to background values in the shock downstream where chondrules acquire magnetizations, and that these locations are sufficiently far from the planetary embryos that chondrules should not have recorded a significant putative dynamo field generated on these bodies. We conclude that, if melted in planetary bow shocks, chondrules probably recorded the background nebular field.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Shettel, D.L. Jr.; Langfeldt, S.L.; Youngquist, C.A.

This report presents a Hydrogeochemical and Stream Sediment Reconnaissance of the Christian NTMS Quadrangle, Alaska. In addition to this abbreviated data release, more complete data are available to the public in machine-readable form. These machine-readable data, as well as quarterly or semiannual program progress reports containing further information on the HSSR program in general, or on the Los Alamos National Laboratory portion of the program in particular, are available from DOE's Technical Library at its Grand Junction Area Office. Presented in this data release are location data, field analyses, and laboratory analyses of several different sample media. For the sakemore » of brevity, many field site observations have not been included in this volume; these data are, however, available on the magnetic tape. Appendices A through D describe the sample media and summarize the analytical results for each medium. The data have been subdivided by one of the Los Alamos National Laboratory sorting programs of Zinkl and others (1981a) into groups of stream-sediment, lake-sediment, stream-water, lake-water, and ground-water samples. For each group which contains a sufficient number of observations, statistical tables, tables of raw data, and 1:1,000,000 scale maps of pertinent elements have been included in this report. Also included are maps showing results of multivariate statistical analyses.« less
Rational development of solid dispersions via hot-melt extrusion using screening, material characterization, and numeric simulation tools.

PubMed

Zecevic, Damir E; Wagner, Karl G

2013-07-01

Effective and predictive small-scale selection tools are inevitable during the development of a solubility enhanced drug product. For hot-melt extrusion, this selection process can start with a microscale performance evaluation on a hot-stage microscope (HSM). A batch size of 400 mg can provide sufficient materials to assess the drug product attributes such as solid-state properties, solubility enhancement, and physical stability as well as process related attributes such as processing temperature in a twin-screw extruder (TSE). Prototype formulations will then be fed into a 5 mm TSE (~1-2 g) to confirm performance from the HSM under additional shear stress. Small stress stability testing might be performed with these samples or a larger batch (20-40 g) made by 9 or 12 mm TSE. Simultaneously, numeric process simulations are performed using process data as well as rheological and thermal properties of the formulations. Further scale up work to 16 and 18 mm TSE confirmed and refined the simulation model. Thus, at the end of the laboratory-scale development, not only the clinical trial supply could be manufactured, but also one can form a sound risk assessment to support further scale up even without decades of process experience. Copyright © 2013 Wiley Periodicals, Inc.
NASA Downscaling Project: Final Report

NASA Technical Reports Server (NTRS)

Ferraro, Robert; Waliser, Duane; Peters-Lidard, Christa

2017-01-01

A team of researchers from NASA Ames Research Center, Goddard Space Flight Center, the Jet Propulsion Laboratory, and Marshall Space Flight Center, along with university partners at UCLA, conducted an investigation to explore whether downscaling coarse resolution global climate model (GCM) predictions might provide valid insights into the regional impacts sought by decision makers. Since the computational cost of running global models at high spatial resolution for any useful climate scale period is prohibitive, the hope for downscaling is that a coarse resolution GCM provides sufficiently accurate synoptic scale information for a regional climate model (RCM) to accurately develop fine scale features that represent the regional impacts of a changing climate. As a proxy for a prognostic climate forecast model, and so that ground truth in the form of satellite and in-situ observations could be used for evaluation, the MERRA and MERRA - 2 reanalyses were used to drive the NU - WRF regional climate model and a GEOS - 5 replay. This was performed at various resolutions that were at factors of 2 to 10 higher than the reanalysis forcing. A number of experiments were conducted that varied resolution, model parameterizations, and intermediate scale nudging, for simulations over the continental US during the period from 2000 - 2010. The results of these experiments were compared to observational datasets to evaluate the output.

NASA Downscaling Project

NASA Technical Reports Server (NTRS)

Ferraro, Robert; Waliser, Duane; Peters-Lidard, Christa

2017-01-01

A team of researchers from NASA Ames Research Center, Goddard Space Flight Center, the Jet Propulsion Laboratory, and Marshall Space Flight Center, along with university partners at UCLA, conducted an investigation to explore whether downscaling coarse resolution global climate model (GCM) predictions might provide valid insights into the regional impacts sought by decision makers. Since the computational cost of running global models at high spatial resolution for any useful climate scale period is prohibitive, the hope for downscaling is that a coarse resolution GCM provides sufficiently accurate synoptic scale information for a regional climate model (RCM) to accurately develop fine scale features that represent the regional impacts of a changing climate. As a proxy for a prognostic climate forecast model, and so that ground truth in the form of satellite and in-situ observations could be used for evaluation, the MERRA and MERRA-2 reanalyses were used to drive the NU-WRF regional climate model and a GEOS-5 replay. This was performed at various resolutions that were at factors of 2 to 10 higher than the reanalysis forcing. A number of experiments were conducted that varied resolution, model parameterizations, and intermediate scale nudging, for simulations over the continental US during the period from 2000-2010. The results of these experiments were compared to observational datasets to evaluate the output.
Timeliness of notification systems for infectious diseases: A systematic literature review.

PubMed

Swaan, Corien; van den Broek, Anouk; Kretzschmar, Mirjam; Richardus, Jan Hendrik

2018-01-01

Timely notification of infectious diseases is crucial for prompt response by public health services. Adequate notification systems facilitate timely notification. A systematic literature review was performed to assess outcomes of studies on notification timeliness and to determine which aspects of notification systems are associated with timely notification. Articles reviewing timeliness of notifications published between 2000 and 2017 were searched in Pubmed and Scopus. Using a standardized notification chain, timeliness of reporting system for each article was defined as either sufficient (≥ 80% notifications in time), partly sufficient (≥ 50-80%), or insufficient (< 50%) according to the article's predefined timeframe, a standardized timeframe for all articles, and a disease specific timeframe. Electronic notification systems were compared with conventional methods (postal mail, fax, telephone, email) and mobile phone reporting. 48 articles were identified. In almost one third of the studies with a predefined timeframe (39), timeliness of notification systems was either sufficient or insufficient (11/39, 28% and 12/39, 31% resp.). Applying the standardized timeframe (45 studies) revealed similar outcomes (13/45, 29%, sufficient notification timeframe, vs 15/45, 33%, insufficient). The disease specific timeframe was not met by any study. Systems involving reporting by laboratories most often complied sufficiently with predefined or standardized timeframes. Outcomes were not related to electronic, conventional notification systems or mobile phone reporting. Electronic systems were faster in comparative studies (10/13); this hardly resulted in sufficient timeliness, neither according to predefined nor to standardized timeframes. A minority of notification systems meets either predefined, standardized or disease specific timeframes. Systems including laboratory reporting are associated with timely notification. Electronic systems reduce reporting delay, but implementation needs considerable effort to comply with notification timeframes. During outbreak threats, patient, doctors and laboratory testing delays need to be reduced to achieve timely detection and notification. Public health authorities should incorporate procedures for this in their preparedness plans.
Validating the Collision-Dominated Child-Langmuir Law for a DC Discharge Cathode Sheath in an Undergraduate Laboratory

ERIC Educational Resources Information Center

Lisovskiy, V.; Yegorenkov, V.

2009-01-01

In this paper, we propose a simple method of observing the collision-dominated Child-Langmuir law in the course of an undergraduate laboratory work devoted to studying the properties of gas discharges. To this end we employ the dc gas discharge whose properties are studied in sufficient detail. The undergraduate laboratory work itself is reduced…
A Mixed Learning Approach to Integrating Digital Signal Processing Laboratory Exercises into a Non-Lab Junior Year DSP Course

ERIC Educational Resources Information Center

McPheron, Benjamin D.; Thangaraj, Charles V.; Thomas, Charles R.

2017-01-01

Laboratory courses can be difficult to fit into an engineering program at a liberal arts-focused university, which requires students to be exposed to appropriate breadth, as well as sufficient depth in their engineering education. One possible solution to this issue is to integrate laboratory exercises with lecture in a "studio" format,…
Pulsed CO2 characterization for lidar use

NASA Technical Reports Server (NTRS)

Jaenisch, Holger M.

1992-01-01

An account is given of a scaled functional testbed laser for space-qualified coherent-detection lidar applications which employs a CO2 laser. This laser has undergone modification and characterization for inherent performance capabilities as a model of coherent detection. While characterization results show good overall performance that is in agreement with theoretical predictions, frequency-stability and pulse-length limitations severely limit the laser's use in coherent detection.
Professional Development during a Period of Change: A Small-Scale Case Study Exploring the Effect of Context on Practice in a South African Rural School

ERIC Educational Resources Information Center

Bryan, Chris

2011-01-01

Education in post-apartheid South Africa has undergone considerable change in recent years and is seen as providing the key to reform and social transformation. However, despite many government policies designed to improve the quality of teaching and learning, education continues to present challenges, particularly within the area of professional…
Macro-scale assessment of demographic and environmental variation within genetically derived evolutionary lineages of eastern hemlock (Tsuga canadensis), an imperiled conifer of the eastern United States

Treesearch

Anantha M. Prasad; Kevin M. Potter

2017-01-01

Eastern hemlock (Tsuga canadensis) occupies a large swath of eastern North America and has historically undergone range expansion and contraction resulting in several genetically separate lineages. This conifer is currently experiencing mortality across most of its range following infestation of a non-native insect. With the goal of better...
Detecting mortality induced structural and functional changes in a pinon-juniper woodland using Landsat and RapidEye time series

Treesearch

Dan J. Krofcheck; Jan U. H. Eitel; Lee A. Vierling; Urs Schulthess; Timothy M. Hilton; Eva Dettweiler-Robinson; Rosemary Pendleton; Marcy E. Litvak

2014-01-01

Pinon-juniper (PJ) woodlands have recently undergone dramatic drought-induced mortality, triggering broad scale structural changes in this extensive Southwestern US biome. Given that climate projections for the region suggest widespread conifer mortality is likely to continue into the next century, it is critical to better understand how this climate-induced change in...
Rapid Automated Antimicrobial Susceptibility Testing of Streptococcus pneumoniae by Use of the bioMerieux VITEK 2

PubMed Central

Jorgensen, James H.; Barry, Arthur L.; Traczewski, M. M.; Sahm, Daniel F.; McElmeel, M. Leticia; Crawford, Sharon A.

2000-01-01

The VITEK 2 is a new automated instrument for rapid organism identification and susceptibility testing. It has the capability of performing rapid susceptibility testing of Streptococcus pneumoniae with specially configured cards that contain enriched growth medium and antimicrobial agents relevant for this organism. The present study compared the results of testing of a group of 53 challenge strains of pneumococci with known resistance properties and a collection of clinical isolates examined in two study phases with a total of 402 and 416 isolates, respectively, with a prototype of the VITEK 2. Testing was conducted in three geographically separate laboratories; the challenge collection was tested by all three laboratories, and the unique clinical isolates were tested separately by the individual laboratories. The VITEK 2 results of tests with 10 antimicrobial agents were compared to the results generated by the National Committee for Clinical Laboratory Standards reference broth microdilution MIC test method. Excellent interlaboratory agreement was observed with the challenge strains. The overall agreement within a single twofold dilution of MICs defined by the VITEK 2 and reference method with the clinical isolates was 96.3%, although there were a number of off-scale MICs that could not be compared. The best agreement with the clinical isolates was achieved with ofloxacin and chloramphenicol (100%), and the lowest level of agreement among those drugs with sufficient on-scale MICs occurred with trimethoprim-sulfamethoxazole (89.7%). Overall there were 1.3% very major, 6.6% minor, and no major interpretive category errors encountered with the clinical isolates, although >80% of the minor interpretive errors involved only a single log2 dilution difference. The mean time for generation of susceptibility results with the clinical isolates was 8.1 h. The VITEK 2 provided rapid, reliable susceptibility category determinations with both the challenge and clinical isolates examined in this study. PMID:10921932
Innovative mathematical modeling in environmental remediation.

PubMed

Yeh, Gour-Tsyh; Gwo, Jin-Ping; Siegel, Malcolm D; Li, Ming-Hsu; Fang, Yilin; Zhang, Fan; Luo, Wensui; Yabusaki, Steve B

2013-05-01

There are two different ways to model reactive transport: ad hoc and innovative reaction-based approaches. The former, such as the Kd simplification of adsorption, has been widely employed by practitioners, while the latter has been mainly used in scientific communities for elucidating mechanisms of biogeochemical transport processes. It is believed that innovative mechanistic-based models could serve as protocols for environmental remediation as well. This paper reviews the development of a mechanistically coupled fluid flow, thermal transport, hydrologic transport, and reactive biogeochemical model and example-applications to environmental remediation problems. Theoretical bases are sufficiently described. Four example problems previously carried out are used to demonstrate how numerical experimentation can be used to evaluate the feasibility of different remediation approaches. The first one involved the application of a 56-species uranium tailing problem to the Melton Branch Subwatershed at Oak Ridge National Laboratory (ORNL) using the parallel version of the model. Simulations were made to demonstrate the potential mobilization of uranium and other chelating agents in the proposed waste disposal site. The second problem simulated laboratory-scale system to investigate the role of natural attenuation in potential off-site migration of uranium from uranium mill tailings after restoration. It showed inadequacy of using a single Kd even for a homogeneous medium. The third example simulated laboratory experiments involving extremely high concentrations of uranium, technetium, aluminum, nitrate, and toxic metals (e.g., Ni, Cr, Co). The fourth example modeled microbially-mediated immobilization of uranium in an unconfined aquifer using acetate amendment in a field-scale experiment. The purposes of these modeling studies were to simulate various mechanisms of mobilization and immobilization of radioactive wastes and to illustrate how to apply reactive transport models for environmental remediation. Copyright © 2011 Elsevier Ltd. All rights reserved.
The Relationships between University Students' Chemistry Laboratory Anxiety, Attitudes, and Self-Efficacy Beliefs

ERIC Educational Resources Information Center

Kurbanoglu, N. Izzet; Akin, Ahmet

2010-01-01

The aim of this study is to examine the relationships between chemistry laboratory anxiety, chemistry attitudes, and self-efficacy. Participants were 395 university students. Participants completed the Chemistry Laboratory Anxiety Scale, the Chemistry Attitudes Scale, and the Self-efficacy Scale. Results showed that chemistry laboratory anxiety…
Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods

NASA Astrophysics Data System (ADS)

Fonseca, Ana S.; Kuijpers, Eelco; Kling, Kirsten I.; Levin, Marcus; Koivisto, Antti J.; Nielsen, Signe H.; Fransman, W.; Fedutik, Yijri; Jensen, Keld A.; Koponen, Ismo K.

2018-02-01

Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers' inhalation exposure during synthesis and handling of CuO, TiO2 and ZnO in a fume hood. In addition, we tested the capacity of a fume hood to prevent particle release to laboratory air during simulated spillage of different powders (silica fume, zirconia TZ-3Y and TiO2). Airborne particle concentrations were measured in near field, far field, and in the breathing zone of the worker. Handling CuO nanoparticles increased the concentration of small particles (< 58 nm) inside the fume hood (up to 1 × 105 cm-3). Synthesis, handling and packaging of ZnO and TiO2 nanoparticles did not result in detectable particle release to the laboratory air. Simulated powder spills showed a systematic increase in the particle concentrations inside the fume hood with increasing amount of material and drop height. Despite powder spills were sometimes observed to eject into the laboratory room, the spill events were rarely associated with notable release of particles from the fume hood. Overall, this study shows that a fume hood generally offers sufficient exposure control during synthesis and handling of nanomaterials. An appropriate fume hood with adequate sash height and face velocity prevents 98.3% of particles release into the surrounding environment. Care should still be made to consider spills and high cleanliness to prevent exposure via resuspension and inadvertent exposure by secondary routes.
Introduction of optical tweezers in advanced physics laboratory

NASA Astrophysics Data System (ADS)

Wang, Gang

2017-08-01

Laboratories are an essential part of undergraduate optoelectronics and photonics education. Of particular interest are the sequence of laboratories which offer students meaningful research experience within a reasonable time-frame limited by regular laboratory hours. We will present our introduction of optical tweezers into the upper-level physics laboratory. We developed the sequence of experiments in the Advanced Lab to offer students sufficient freedom to explore, rather than simply setting up a demonstration following certain recipes. We will also present its impact on our current curriculum of optoelectronics concentration within the physics program.
Scale factor management in the studies of affine models of shockproof garment elements

NASA Astrophysics Data System (ADS)

Denisov, Oleg; Pleshko, Mikhail; Ponomareva, Irina; Merenyashev, Vitaliy

2018-03-01

New samples of protective garment for performing construction work at height require numerous tests in conditions close to real conditions of extreme vital activity. The article presents some results of shockproof garment element studies and a description of a patented prototype. The tests were carried out on a model which geometric dimensions were convenient for manufacturing it in a limited batch. In addition, the used laboratory equipment (for example, a unique power pendulum), blanks made of a titanium-nickel alloy with a shape memory effect also imposed their limitations. The problem of the adequacy of the obtained experimental results transfer to mass-produced products was solved using tools of the classical similarity theory. Scale factor management influence in the affine modeling of the shockproof element, studied on the basis of the equiatomic titanium-nickel alloy with the shape memory effect, allowed us to assume, with a sufficient degree of reliability, the technical possibility of extrapolating the results of experimental studies to full-scale objects for the formation of the initial data of the mathematical model of shockproof garment dynamics elastoplastic deformation (while observing the similarity of the features of external loading).
Parallel production and verification of protein products using a novel high-throughput screening method.

PubMed

Tegel, Hanna; Yderland, Louise; Boström, Tove; Eriksson, Cecilia; Ukkonen, Kaisa; Vasala, Antti; Neubauer, Peter; Ottosson, Jenny; Hober, Sophia

2011-08-01

Protein production and analysis in a parallel fashion is today applied in laboratories worldwide and there is a great need to improve the techniques and systems used for this purpose. In order to save time and money, a fast and reliable screening method for analysis of protein production and also verification of the protein product is desired. Here, a micro-scale protocol for the parallel production and screening of 96 proteins in plate format is described. Protein capture was achieved using immobilized metal affinity chromatography and the product was verified using matrix-assisted laser desorption ionization time-of-flight MS. In order to obtain sufficiently high cell densities and product yield in the small-volume cultivations, the EnBase® cultivation technology was applied, which enables cultivation in as small volumes as 150 μL. Here, the efficiency of the method is demonstrated by producing 96 human, recombinant proteins, both in micro-scale and using a standard full-scale protocol and comparing the results in regard to both protein identity and sample purity. The results obtained are highly comparable to those acquired through employing standard full-scale purification protocols, thus validating this method as a successful initial screening step before protein production at a larger scale. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Description of the Spacecraft Control Laboratory Experiment (SCOLE) facility

NASA Technical Reports Server (NTRS)

Williams, Jeffrey P.; Rallo, Rosemary A.

1987-01-01

A laboratory facility for the study of control laws for large flexible spacecraft is described. The facility fulfills the requirements of the Spacecraft Control Laboratory Experiment (SCOLE) design challenge for a laboratory experiment, which will allow slew maneuvers and pointing operations. The structural apparatus is described in detail sufficient for modelling purposes. The sensor and actuator types and characteristics are described so that identification and control algorithms may be designed. The control implementation computer and real-time subroutines are also described.
Description of the Spacecraft Control Laboratory Experiment (SCOLE) facility

NASA Technical Reports Server (NTRS)

Williams, Jeffrey P.; Rallo, Rosemary A.

1987-01-01

A laboratory facility for the study of control laws for large flexible spacecraft is described. The facility fulfills the requirements of the Spacecraft Control Laboratory Experiment (SCOLE) design challenge for laboratory experiments, which will allow slew maneuvers and pointing operations. The structural apparatus is described in detail sufficient for modelling purposes. The sensor and actuator types and characteristics are described so that identification and control algorithms may be designed. The control implementation computer and real-time subroutines are also described.
Secondary flow structures in large rivers

NASA Astrophysics Data System (ADS)

Chauvet, H.; Devauchelle, O.; Metivier, F.; Limare, A.; Lajeunesse, E.

2012-04-01

Measuring the velocity field in large rivers remains a challenge, even with recent measurement techniques such as Acoustic Doppler Current Profiler (ADCP). Indeed, due to the diverging angle between its ultrasonic beams, an ADCP cannot detect small-scale flow structures. However, when the measurements are limited to a single location for a sufficient period of time, averaging can reveal large, stationary flow structures. Here we present velocity measurements in a straight reach of the Seine river in Paris, France, where the cross-section is close to rectangular. The transverse modulation of the streamwise velocity indicates secondary flow cells, which seem to occupy the entire width of the river. This observation is reminiscent of the longitudinal vortices observed in laboratory experiments (e.g. Blanckaert et al., Advances in Water Resources, 2010, 33, 1062-1074). Although the physical origin of these secondary structures remains unclear, their measured velocity is sufficient to significantly impact the distribution of streamwise momentum. We propose a model for the transverse profile of the depth-averaged velocity based on a crude representation of the longitudinal vortices, with a single free parameter. Preliminary results are in good agreement with field measurements. This model also provides an estimate for the bank shear stress, which controls bank erosion.
Spacecraft On-Board Information Extraction Computer (SOBIEC)

NASA Technical Reports Server (NTRS)

Eisenman, David; Decaro, Robert E.; Jurasek, David W.

1994-01-01

The Jet Propulsion Laboratory is the Technical Monitor on an SBIR Program issued for Irvine Sensors Corporation to develop a highly compact, dual use massively parallel processing node known as SOBIEC. SOBIEC couples 3D memory stacking technology provided by nCUBE. The node contains sufficient network Input/Output to implement up to an order-13 binary hypercube. The benefit of this network, is that it scales linearly as more processors are added, and it is a superset of other commonly used interconnect topologies such as: meshes, rings, toroids, and trees. In this manner, a distributed processing network can be easily devised and supported. The SOBIEC node has sufficient memory for most multi-computer applications, and also supports external memory expansion and DMA interfaces. The SOBIEC node is supported by a mature set of software development tools from nCUBE. The nCUBE operating system (OS) provides configuration and operational support for up to 8000 SOBIEC processors in an order-13 binary hypercube or any subset or partition(s) thereof. The OS is UNIX (USL SVR4) compatible, with C, C++, and FORTRAN compilers readily available. A stand-alone development system is also available to support SOBIEC test and integration.
Assessing sufficiency of thermal riverscapes for resilient ...

EPA Pesticide Factsheets

Resilient salmon populations require river networks that provide water temperature regimes sufficient to support a diversity of salmonid life histories across space and time. Efforts to protect, enhance and restore watershed thermal regimes for salmon may target specific locations and features within stream networks hypothesized to provide disproportionately high-value functional resilience to salmon populations. These include relatively small-scale features such as thermal refuges, and larger-scale features such as entire watersheds or aquifers that support thermal regimes buffered from local climatic conditions. Quantifying the value of both small and large scale thermal features to salmon populations has been challenged by both the difficulty of mapping thermal regimes at sufficient spatial and temporal resolutions, and integrating thermal regimes into population models. We attempt to address these challenges by using newly-available datasets and modeling approaches to link thermal regimes to salmon populations across scales. We will describe an individual-based modeling approach for assessing sufficiency of thermal refuges for migrating salmon and steelhead in large rivers, as well as a population modeling approach for assessing large-scale climate refugia for salmon in the Pacific Northwest. Many rivers and streams in the Pacific Northwest are currently listed as impaired under the Clean Water Act as a result of high summer water temperatures. Adverse effec

A Thermal Technique of Fault Nucleation, Growth, and Slip

NASA Astrophysics Data System (ADS)

Garagash, D.; Germanovich, L. N.; Murdoch, L. C.; Martel, S. J.; Reches, Z.; Elsworth, D.; Onstott, T. C.

2009-12-01

Fractures and fluids influence virtually all mechanical processes in the crust, but many aspects of these processes remain poorly understood largely because of a lack of controlled field experiments at appropriate scale. We have developed an in-situ experimental approach to create carefully controlled faults at scale of ~10 meters using thermal techniques to modify in situ stresses to the point where the rock fails in shear. This approach extends experiments on fault nucleation and growth to length scales 2-3 orders of magnitude greater than are currently possible in the laboratory. The experiments could be done at depths where the modified in situ stresses are sufficient to drive faulting, obviating the need for unrealistically large loading frames. Such experiments require an access to large rock volumes in the deep subsurface in a controlled setting. The Deep Underground Science and Engineering Laboratory (DUSEL), which is a research facility planned to occupy the workings of the former Homestake gold mine in the northern Black Hills, South Dakota, presents an opportunity for accessing locations with vertical stresses as large as 60 MPa (down to 2400 m depth), which is sufficient to create faults. One of the most promising methods for manipulating stresses to create faults that we have evaluated involves drilling two parallel planar arrays of boreholes and circulating cold fluid (e.g., liquid nitrogen) to chill the region in the vicinity of the boreholes. Cooling a relatively small region around each borehole causes the rock to contract, reducing the normal compressive stress throughout much larger region between the arrays of boreholes. This scheme was evaluated using both scaling analysis and a finite element code. Our results show that if the boreholes are spaced by ~1 m, in several days to weeks, the normal compressive stress can be reduced by 10 MPa or more, and it is even possible to create net tension between the borehole arrays. According to the Mohr-Coulomb strength criterion with standard Byerlee parameters, a fault will initiate before the net tension occurs. After a new fault is created, hot fluid can be injected into the boreholes to increase the temperature and reverse the direction of fault slip. This process can be repeated to study the formation of gouge, and how the properties of gouge control fault slip and associated seismicity. Instrumenting the site with arrays of geophones, tiltmeters, strain gauges, and displacement transducers as well as back mining - an opportunity provided by the DUSEL project - can reveal details of the fault geometry and gouge. We also expect to find small faults (with cm-scale displacement) during construction of DUSEL drifts. The same thermal technique can be used to induce slip on one of them and compare the “man-made” and natural gouges. The thermal technique appears to be a relatively simple way to rapidly change the stress field and either create slip on existing fractures or create new faults at scales up to 10 m or more.
CMPO purity tests in the TRUEX solvent using americium-241

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brewer, K.N.; Herbst, R.S.; Tranter, T.J.

1993-12-01

The Transuranic Extraction (TRUEX) Process was developed by E.P. Horwitz and coworkers at Argonne National Laboratory (ANL) to separate the +4, +6, and +3 actinides from acidic aqueous solutions of nuclear wastes. Octyl (phenyl)-N-N-diisobutyl-carbamoylmethylphosphine oxide (CMPO) is the active actinide complexant used in the TRUEX solvent. CMPO is combined with tributyl phosphate (TBP) in an organic diluent, typically n-dodecane, to form the TRUEX solvent. Small quantities of impurities in the CMPO resulting from: (1) synthesis, (2) acid hydrolysis, or (3) radiolysis can result in actinide stripping problems from the solvent. The impurity, octylphenylphosphinic acid (POPPA), ia a powerful extractant atmore » low acid concentrations which may be formed during CMPO synthesis. Consequently, commercial CMPO may contain sufficient quantities of POPPA to significantly impact the stripping of actinides from the TRUEX solvent. The purpose of these tests was to (1) determine if commercially available CMPO is sufficiently pure to alleviate actinide stripping problems from the TRUEX process and (2) to determine if solvent cleanup methods are sufficient to purify the commercially purchased CMPO. Extraction and solvent cleanup methodologies used by Horwitz and coworkers at ANL were used to determine CMPO purity with {sup 241}Am. The improvement of the americium distribution coefficient in dilute nitric acid resulting from further purifying this CMPO is not significant enough to warrant additional CMPO purifying steps. The commercially purchased CMPO is found to be acceptable to use, as received, in a full-scale TRUEX process.« less
Brain Modules, Personality Layers, Planes of Being, Spiral Structures, and the Equally Implausible Distinction between TCI-R "Temperament" and "Character" Scales: Reply to Cloninger (2008)

ERIC Educational Resources Information Center

Farmer, Richard F.; Goldberg, Lewis R.

2008-01-01

In this reply the authors address comments by C. R. Cloninger (2008) related to their report (R. F. Farmer & L. R. Goldberg, 2008) on the psychometric properties of the revised Temperament and Character Inventory (TCI-R) and a short inventory derivative, the TCI-140. Even though Cloninger's psychobiological model has undergone substantial…
Does preoperative physiotherapy improve postoperative, patient-based outcomes in older adults who have undergone total knee arthroplasty? A systematic review.

PubMed

Chesham, Ross Alexander; Shanmugam, Sivaramkumar

2017-01-01

Knee osteoarthritis (OA) is a leading cause of disability in older adults (≥60) in the UK. If nonsurgical management fails and if OA severity becomes too great, knee arthroplasty is a preferred treatment choice. Preoperative physiotherapy is often offered as part of rehabilitation to improve postoperative patient-based outcomes. Systematically review whether preoperative physiotherapy improves postoperative, patient-based outcomes in older adults who have undergone total knee arthroplasty (TKA) and compare study interventions to best-practice guidelines. A literature search of Randomized Controlled Trials (RCTs), published April 2004-April 2014, was performed across six databases. Individual studies were evaluated for quality using the PEDro Scale. Ten RCTs met the full inclusion/exclusion criteria. RCTs compared control groups versus: preoperative exercise (n = 5); combined exercise and education (n = 2); combined exercise and acupuncture (n = 1); neuromuscular electrical stimulation (NMES; n = 1); and acupuncture versus exercise (n = 1). RCTs recorded many patient-based outcomes including knee strength, ambulation, and pain. Minimal evidence is presented that preoperative physiotherapy is more effective than no physiotherapy or usual care. PEDro Scale and critical appraisal highlighted substantial methodological quality issues within the RCTs. There is insufficient quality evidence to support the efficacy of preoperative physiotherapy in older adults who undergo total knee arthroplasty.
The impact of automating laboratory request forms on the quality of healthcare services.

PubMed

Dogether, Majed Al; Muallem, Yahya Al; Househ, Mowafa; Saddik, Basema; Khalifa, Mohamed

In recent decades, healthcare organizations have undergone a significant transformation with the integration of Information and Communication Technologies within healthcare operations to improve healthcare services. Various technologies such as Hospital Information Systems (HIS), Electronic Health Records (EHR) and Laboratory Information Systems (LIS) have been incorporated into healthcare services. The aim of this study is to evaluate the completeness of outpatients' laboratory paper based request forms in comparison with a electronic laboratory request system. This study was carried out in the laboratory department at King Abdulaziz Medical City (KAMC), National Guard Health Affairs, Riyadh, Saudi Arabia. We used a sample size calculator for comparing two proportions. We estimated the sample size to be 228 for each group. Any laboratory requests including paper and electronic forms were included. We categorized the clarity of the forms into understandable, readable, and unclear. A total of 57 incomplete paper forms or 25% were identified as being incomplete. For electronic forms, there were no incomplete fields, as all fields were mandatory, therefore, rendering them complete. The total of understandable paper-based laboratory forms was 11.4%. Additionally, it was found that the total of readable was 33.8% and the total for unclear was 54.8%, while for electronic-based forms, there were no unclear forms. Electronic based laboratory forms provide a more complete, accurate, clear, and understandable format than paper-based laboratory records. Based on these findings, KAMC should move toward the implementation of electronic-based laboratory request forms for the outpatient laboratory department. Copyright © 2016 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.
Nitrate reduction in a simulated free-water surface wetland system.

PubMed

Misiti, Teresa M; Hajaya, Malek G; Pavlostathis, Spyros G

2011-11-01

The feasibility of using a constructed wetland for treatment of nitrate-contaminated groundwater resulting from the land application of biosolids was investigated for a site in the southeastern United States. Biosolids degradation led to the release of ammonia, which upon oxidation resulted in nitrate concentrations in the upper aquifer in the range of 65-400 mg N/L. A laboratory-scale system was constructed in support of a pilot-scale project to investigate the effect of temperature, hydraulic retention time (HRT) and nitrate and carbon loading on denitrification using soil and groundwater from the biosolids application site. The maximum specific reduction rates (MSRR), measured in batch assays conducted with an open to the atmosphere reactor at four initial nitrate concentrations from 70 to 400 mg N/L, showed that the nitrate reduction rate was not affected by the initial nitrate concentration. The MSRR values at 22 °C for nitrate and nitrite were 1.2 ± 0.2 and 0.7 ± 0.1 mg N/mg VSS(COD)-day, respectively. MSRR values were also measured at 5, 10, 15 and 22 °C and the temperature coefficient for nitrate reduction was estimated at 1.13. Based on the performance of laboratory-scale continuous-flow reactors and model simulations, wetland performance can be maintained at high nitrogen removal efficiency (>90%) with an HRT of 3 days or higher and at temperature values as low as 5 °C, as long as there is sufficient biodegradable carbon available to achieve complete denitrification. The results of this study show that based on the climate in the southeastern United States, a constructed wetland can be used for the treatment of nitrate-contaminated groundwater to low, acceptable nitrate levels. Copyright © 2011 Elsevier Ltd. All rights reserved.
The study of the effects of sea-spray drops on the marine atmospheric boundary layer by direct numerical simulation

NASA Astrophysics Data System (ADS)

Druzhinin, O.; Troitskaya, Yu; Zilitinkevich, S.

2018-01-01

The detailed knowledge of turbulent exchange processes occurring in the atmospheric marine boundary layer are of primary importance for their correct parameterization in large-scale prognostic models. These processes are complicated, especially at sufficiently strong wind forcing conditions, by the presence of sea-spray drops which are torn off the crests of sufficiently steep surface waves by the wind gusts. Natural observations indicate that mass fraction of sea-spray drops increases with wind speed and their impact on the dynamics of the air in the vicinity of the sea surface can become quite significant. Field experiments, however, are limited by insufficient accuracy of the acquired data and are in general costly and difficult. Laboratory modeling presents another route to investigate the spray-mediated exchange processes in much more detail as compared to the natural experiments. However, laboratory measurements, contact as well as Particle Image Velocimetry (PIV) methods, also suffer from inability to resolve the dynamics of the near-surface air-flow, especially in the surface wave troughs. In this report, we present a first attempt to use Direct Numerical Simulation (DNS) as tool for investigation of the drops-mediated momentum, heat and moisture transfer in a turbulent, droplet-laden air flow over a wavy water surface. DNS is capable of resolving the details of the transfer processes and do not involve any closure assumptions typical of Large-Eddy and Reynolds Averaged Navier-Stokes (LES and RANS) simulations. Thus DNS provides a basis for improving parameterizations in LES and RANS closure models and further development of large-scale prognostic models. In particular, we discuss numerical results showing the details of the modification of the air flow velocity, temperature and relative humidity fields by multidisperse, evaporating drops. We use Eulerian-Lagrangian approach where the equations for the air-flow fields are solved in a Eulerian frame whereas the drops dymanics equations are solved in a Largangain frame. The effects of air flow and drops on the water surface wave are neglected. A point-force approximation is employed to model the feed-back contributions by the drops to the air momentum, heat and moisture transfer.
21 CFR 58.43 - Animal care facilities.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Animal care facilities. 58.43 Section 58.43 Food... LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Facilities § 58.43 Animal care facilities. (a) A testing facility shall have a sufficient number of animal rooms or areas, as needed, to assure proper: (1...
21 CFR 58.43 - Animal care facilities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Animal care facilities. 58.43 Section 58.43 Food... LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Facilities § 58.43 Animal care facilities. (a) A testing facility shall have a sufficient number of animal rooms or areas, as needed, to assure proper: (1...
21 CFR 58.43 - Animal care facilities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Animal care facilities. 58.43 Section 58.43 Food... LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Facilities § 58.43 Animal care facilities. (a) A testing facility shall have a sufficient number of animal rooms or areas, as needed, to assure proper: (1...
21 CFR 58.43 - Animal care facilities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Animal care facilities. 58.43 Section 58.43 Food... LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Facilities § 58.43 Animal care facilities. (a) A testing facility shall have a sufficient number of animal rooms or areas, as needed, to assure proper: (1...
21 CFR 58.43 - Animal care facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Animal care facilities. 58.43 Section 58.43 Food... LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Facilities § 58.43 Animal care facilities. (a) A testing facility shall have a sufficient number of animal rooms or areas, as needed, to assure proper: (1...
The role of simulation in surgical training.

PubMed Central

Torkington, J.; Smith, S. G.; Rees, B. I.; Darzi, A.

2000-01-01

Surgical training has undergone many changes in the last decade. One outcome of these changes is the interest that has been generated in the possibility of training surgical skills outside the operating theatre. Simulation of surgical procedures and human tissue, if perfect, would allow complete transfer of techniques learnt in a skills laboratory directly to the operating theatre. Several techniques of simulation are available including artificial tissues, animal models and virtual reality computer simulation. Each is discussed in this article and their advantages and disadvantages considered. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:10743423
21. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHWEST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. AERIAL VIEW OF THE ROCKY FLATS PLANT LOOKING NORTHWEST. BY THE LATE 1960S, THE SITE HAD UNDERGONE TWO MAJOR EXPANSIONS. THE FIRST EXPANSION IN 1956-57, WHEN THE TRIGGER DESIGN CHANGED AND NECESSITATED THE ADDITION OF SEVEN NEW BUILDINGS. THE SECOND LARGE EXPANSION TOOK PLACE FROM 1964-65, WHEN ROCKY FLATS BECAME THE SOLE PRODUCER OF TRIGGERS. DURING THIS EXPANSION, ELEVEN BUILDINGS WERE ADDED, PRIMARILY IN RESEARCH AND DEVELOPMENT LABORATORIES, GUARD HOUSES, AND WASTE WATER TREATMENT (7/1/69). - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO
Pedagogical effectiveness of innovative teaching methods initiated at the Department of Physiology, Government Medical College, Chandigarh.

PubMed

Nageswari, K Sri; Malhotra, Anita S; Kapoor, Nandini; Kaur, Gurjit

2004-12-01

Modern teaching trends in medical education exhibit a paradigm shift from the conventional classroom teaching methods adopted in the past to nonconventional teaching aids so as to encourage interactive forms of learning in medical students through active participation and integrative reasoning where the relationship of the teacher and the taught has undergone tremendous transformation. Some of the nonconventional teaching methods adopted at our department are learning through active participation by the students through computer-assisted learning (CD-ROMs), Web-based learning (undergraduate projects), virtual laboratories, seminars, audiovisual aids (video-based demonstrations), and "physioquiz."
Simulation of particle diversity and mixing state over Greater Paris: a model-measurement inter-comparison.

PubMed

Zhu, Shupeng; Sartelet, Karine N; Healy, Robert M; Wenger, John C

2016-07-18

Air quality models are used to simulate and forecast pollutant concentrations, from continental scales to regional and urban scales. These models usually assume that particles are internally mixed, i.e. particles of the same size have the same chemical composition, which may vary in space and time. Although this assumption may be realistic for continental-scale simulations, where particles originating from different sources have undergone sufficient mixing to achieve a common chemical composition for a given model grid cell and time, it may not be valid for urban-scale simulations, where particles from different sources interact on shorter time scales. To investigate the role of the mixing state assumption on the formation of particles, a size-composition resolved aerosol model (SCRAM) was developed and coupled to the Polyphemus air quality platform. Two simulations, one with the internal mixing hypothesis and another with the external mixing hypothesis, have been carried out for the period 15 January to 11 February 2010, when the MEGAPOLI winter field measurement campaign took place in Paris. The simulated bulk concentrations of chemical species and the concentrations of individual particle classes are compared with the observations of Healy et al. (Atmos. Chem. Phys., 2013, 13, 9479-9496) for the same period. The single particle diversity and the mixing-state index are computed based on the approach developed by Riemer et al. (Atmos. Chem. Phys., 2013, 13, 11423-11439), and they are compared to the measurement-based analyses of Healy et al. (Atmos. Chem. Phys., 2014, 14, 6289-6299). The average value of the single particle diversity, which represents the average number of species within each particle, is consistent between simulation and measurement (2.91 and 2.79 respectively). Furthermore, the average value of the mixing-state index is also well represented in the simulation (69% against 59% from the measurements). The spatial distribution of the mixing-state index shows that the particles are not mixed in urban areas, while they are well mixed in rural areas. This indicates that the assumption of internal mixing traditionally used in transport chemistry models is well suited to rural areas, but this assumption is less realistic for urban areas close to emission sources.
Large-scale fluctuations in the diffusive decomposition of solid solutions

NASA Astrophysics Data System (ADS)

Karpov, V. G.; Grimsditch, M.

1995-04-01

The concept of an instability in the classic Ostwald ripening theory with respect to compositional fluctuations is suggested. We show that small statistical fluctuations in the precipitate phase lead to gigantic Coulomb-like fluctuations in the solute concentration which in turn affect the ripening. As a result large-scale fluctuations in both the precipitate and solute concentrations appear. These fluctuations are characterized by amplitudes of the order of the average values of the corresponding quantities and by a space scale L~(na)-1/2 which is considerably greater than both the average nuclear radius and internuclear distance. The Lifshitz-Slyozov theory of ripening is shown to remain locally applicable, over length scales much less than L. The implications of these findings for elastic light scattering in solid solutions that have undergone Ostwald ripening are considered.
Persistence in soil of Miscanthus biochar in laboratory and field conditions

PubMed Central

Budai, Alice; O’Toole, Adam; Ma, Xingzhu; Rumpel, Cornelia; Abiven, Samuel

2017-01-01

Evaluating biochars for their persistence in soil under field conditions is an important step towards their implementation for carbon sequestration. Current evaluations might be biased because the vast majority of studies are short-term laboratory incubations of biochars produced in laboratory-scale pyrolyzers. Here our objective was to investigate the stability of a biochar produced with a medium-scale pyrolyzer, first through laboratory characterization and stability tests and then through field experiment. We also aimed at relating properties of this medium-scale biochar to that of a laboratory-made biochar with the same feedstock. Biochars were made of Miscanthus biomass for isotopic C-tracing purposes and produced at temperatures between 600 and 700°C. The aromaticity and degree of condensation of aromatic rings of the medium-scale biochar was high, as was its resistance to chemical oxidation. In a 90-day laboratory incubation, cumulative mineralization was 0.1% for the medium-scale biochar vs. 45% for the Miscanthus feedstock, pointing to the absence of labile C pool in the biochar. These stability results were very close to those obtained for biochar produced at laboratory-scale, suggesting that upscaling from laboratory to medium-scale pyrolyzers had little effect on biochar stability. In the field, the medium-scale biochar applied at up to 25 t C ha-1 decomposed at an estimated 0.8% per year. In conclusion, our biochar scored high on stability indices in the laboratory and displayed a mean residence time > 100 years in the field, which is the threshold for permanent removal in C sequestration projects. PMID:28873471
The hedonic drive to consume palatable foods appears to be lower in gastric band carriers than in severely obese patients who have not undergone a bariatric surgery.

PubMed

Ullrich, J; Ernst, B; Wilms, B; Thurnheer, M; Hallschmid, M; Schultes, B

2013-04-01

We have recently shown that severely obese patients display a markedly enhanced drive to consume palatable food, and that this hedonic hunger is reduced after gastric bypass surgery. Adjustable gastric banding is another frequently performed bariatric operation with unknown effects on hedonic hunger motivation. Here, we compared the level of hedonic hunger in patients who have undergone a gastric banding with that in severely obese patients who have not undergone a bariatric operation and nonobese controls. In a cross-sectional case-control study, 116 gastric banding patients, 138 severely obese patients, and 133 nonobese controls were examined with the Power of Food Scale (PFS), a questionnaire that reliably measures an individual's motivation to consume highly palatable food. While the severely obese patients displayed markedly higher aggregated PFS scores and scores on the subdomain "generally available" and "physically present" food than the nonobese controls (all P < 0.001), the gastric banding patients showed significantly lower scores on all of these variables than the obese patients (all P < 0.001). However, the generally available food score was still higher in gastric banding patients than in the nonobese controls (P = 0.001). Data suggest that adjustable gastric banding may reduce the excessive appetite for palatable foods in severely obese patients. This suggestion needs to be confirmed in longitudinal studies.
Snack foods and dental caries. Investigations using laboratory animals.

PubMed

Grenby, T H

1990-05-05

The nation's eating habits are undergoing major transformation, with a swing away from traditional meals to a huge increase in snack consumption, but very little is known of the nutritional and dental implications of this change. The research project reported here evaluated a range of snack foods in caries-active laboratory animals, comparing them, as dietary ingredients, with noncariogenic and cariogenic (sugar) diets. The findings showed the very low cariogenicity of salted peanuts, followed by ready-salted and salt and vinegar crisps, extruded maize, mixed-starch and prefabricated/fried potato products, and cheese-filled puffs. Other varieties of crisps (cheese and onion and special shapes) proved to be more cariogenic, not far short of semi-sweet biscuits in some cases. It is concluded that the severity of the processing undergone by the snack foods and the nature of the flavouring agents with which they are coated can influence their dental properties.

Soft x-ray power diagnostic improvements at the Omega Laser Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sorce, C.; Schein, J.; Weber, F.

2006-10-15

Soft x-ray power diagnostics are essential for evaluating high temperature laser plasma experiments. The Dante soft x-ray spectrometer, a core diagnostic for radiation flux and temperature measurements of Hohlraums, installed on the Omega Laser Facility at the Laboratory for Laser Energetics has recently undergone a series of upgrades. Work performed at Brookhaven National Laboratory for the development of the National Ignition Facility (NIF) Dante spectrometer enables the Omega Dante to offer a total of 18 absolutely calibrated channels in the energy range from 50 eV to 20 keV. This feature provides Dante with the capability to measure higher, NIF relevant,more » radiation temperatures with increased accuracy including a differentiation of higher energy radiation such as the Au M and L bands. Diagnostic monitoring using experimental data from directly driven Au spherical shots is discussed.« less
METHOD 544. DETERMINATION OF MICROCYSTINS AND ...

EPA Pesticide Factsheets

Method 544 is an accurate and precise analytical method to determine six microcystins (including MC-LR) and nodularin in drinking water using solid phase extraction and liquid chromatography tandem mass spectrometry (SPE-LC/MS/MS). The advantage of this SPE-LC/MS/MS is its sensitivity and ability to speciate the microcystins. This method development task establishes sample preservation techniques, sample concentration and analytical procedures, aqueous and extract holding time criteria and quality control procedures. Draft Method 544 undergone a multi-laboratory verification to ensure other laboratories can implement the method and achieve the quality control measures specified in the method. It is anticipated that Method 544 may be used in UCMR 4 to collect nationwide occurrence data for selected microcystins in drinking water. The purpose of this research project is to develop an accurate and precise analytical method to concentrate and determine selected MCs and nodularin in drinking water.
Surveillance at the molecular level: Developing an integrated network for detecting variation in avian influenza viruses in Indonesia.

PubMed

Hartaningsih, Nining; Wibawa, Hendra; Pudjiatmoko; Rasa, Fadjar Sumping Tjatur; Irianingsih, Sri Handayani; Dharmawan, Rama; Azhar, Muhammad; Siregar, Elly Sawitri; McGrane, James; Wong, Frank; Selleck, Paul; Allen, John; Broz, Ivano; Torchetti, Mia Kim; Dauphin, Gwenaelle; Claes, Filip; Sastraningrat, Wiryadi; Durr, Peter A

2015-06-01

Since 2006, Indonesia has used vaccination as the principal means of control of H5N1-HPAI. During this time, the virus has undergone gradual antigenic drift, which has necessitated changes in seed strains for vaccine production and associated modifications to diagnostic antigens. In order to improve the system of monitoring such viral evolution, the Government of Indonesia, with the assistance of FAO/OFFLU, has developed an innovative network whereby H5N1 isolates are antigenically and genetically characterised. This molecular surveillance network ("Influenza Virus Monitoring" or "IVM") is based on the regional network of veterinary diagnostic laboratories, and is supported by a web-based data management system ("IVM Online"). The example of the Indonesian IVM network has relevance for other countries seeking to establish laboratory networks for the molecular surveillance of avian influenza and other pathogens. Copyright © 2015 Elsevier B.V. All rights reserved.
Manufacturing demonstration of microbially mediated zinc sulfide nanoparticles in pilot-plant scale reactors

DOE PAGES

Moon, Ji-Won; Phelps, Tommy J.; Fitzgerald Jr, Curtis L.; ...

2016-04-27

The thermophilic anaerobic metal-reducing bacterium Thermoanaerobacter sp. X513 efficiently produces zinc sulfide (ZnS) nanoparticles (NPs) in laboratory-scale ( ≤24-L) reactors. To determine whether this process can be up-scaled and adapted for pilot-plant production while maintaining NP yield and quality, a series of meso-scale experiments were performed using 100-l and 900-l reactors. Pasteurization and N 2-sparging replaced autoclaving and boiling for deoxygenating media in the transition from small-scale to pilot-plant reactors. Consecutive 100-L batches using new or recycled media produced ZnS NPs with highly reproducible ~2 nm average crystallite size (ACS) and yields of ~0.5g L -1, similar to small-scale batches.more » The 900-L pilot plant reactor produced ~ 320 g ZnS without process optimization or replacement of used medium; this quantity would be sufficient to form a ZnS thin film with ~120 nm thickness over 0.5 m width 13 km length. At all scales, the bacteria produced significant amounts of acetic, lactic and formic acids, which could be neutralized by the controlled addition of sodium hydroxide without the use of an organic pH buffer, eliminating 98% of the buffer chemical costs. In conclusion, the final NP products were characterized using XRD, ICP-OES, FTIR, DLS, and C/N analyses, which confirmed the growth medium without organic buffer enhanced the ZnS NP properties by reducing carbon and nitrogen surface coatings and supporting better dispersivity with similar ACS.« less
Manufacturing demonstration of microbially mediated zinc sulfide nanoparticles in pilot-plant scale reactors.

PubMed

Moon, Ji-Won; Phelps, Tommy J; Fitzgerald, Curtis L; Lind, Randall F; Elkins, James G; Jang, Gyoung Gug; Joshi, Pooran C; Kidder, Michelle; Armstrong, Beth L; Watkins, Thomas R; Ivanov, Ilia N; Graham, David E

2016-09-01

The thermophilic anaerobic metal-reducing bacterium Thermoanaerobacter sp. X513 efficiently produces zinc sulfide (ZnS) nanoparticles (NPs) in laboratory-scale (≤ 24-L) reactors. To determine whether this process can be up-scaled and adapted for pilot-plant production while maintaining NP yield and quality, a series of pilot-plant scale experiments were performed using 100-L and 900-L reactors. Pasteurization and N2-sparging replaced autoclaving and boiling for deoxygenating media in the transition from small-scale to pilot plant reactors. Consecutive 100-L batches using new or recycled media produced ZnS NPs with highly reproducible ~2-nm average crystallite size (ACS) and yields of ~0.5 g L(-1), similar to the small-scale batches. The 900-L pilot plant reactor produced ~320 g ZnS without process optimization or replacement of used medium; this quantity would be sufficient to form a ZnS thin film with ~120 nm thickness over 0.5 m width × 13 km length. At all scales, the bacteria produced significant amounts of acetic, lactic, and formic acids, which could be neutralized by the controlled addition of sodium hydroxide without the use of an organic pH buffer, eliminating 98 % of the buffer chemical costs. The final NP products were characterized using XRD, ICP-OES, TEM, FTIR, PL, DLS, HPLC, and C/N analyses, which confirmed that the growth medium without organic buffer enhanced the ZnS NP properties by reducing carbon and nitrogen surface coatings and supporting better dispersivity with similar ACS.
Validation of the WIMSD4M cross-section generation code with benchmark results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deen, J.R.; Woodruff, W.L.; Leal, L.E.

1995-01-01

The WIMSD4 code has been adopted for cross-section generation in support of the Reduced Enrichment Research and Test Reactor (RERTR) program at Argonne National Laboratory (ANL). Subsequently, the code has undergone several updates, and significant improvements have been achieved. The capability of generating group-collapsed micro- or macroscopic cross sections from the ENDF/B-V library and the more recent evaluation, ENDF/B-VI, in the ISOTXS format makes the modified version of the WIMSD4 code, WIMSD4M, very attractive, not only for the RERTR program, but also for the reactor physics community. The intent of the present paper is to validate the WIMSD4M cross-section librariesmore » for reactor modeling of fresh water moderated cores. The results of calculations performed with multigroup cross-section data generated with the WIMSD4M code will be compared against experimental results. These results correspond to calculations carried out with thermal reactor benchmarks of the Oak Ridge National Laboratory (ORNL) unreflected HEU critical spheres, the TRX LEU critical experiments, and calculations of a modified Los Alamos HEU D{sub 2}O moderated benchmark critical system. The benchmark calculations were performed with the discrete-ordinates transport code, TWODANT, using WIMSD4M cross-section data. Transport calculations using the XSDRNPM module of the SCALE code system are also included. In addition to transport calculations, diffusion calculations with the DIF3D code were also carried out, since the DIF3D code is used in the RERTR program for reactor analysis and design. For completeness, Monte Carlo results of calculations performed with the VIM and MCNP codes are also presented.« less
Validation of the WIMSD4M cross-section generation code with benchmark results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leal, L.C.; Deen, J.R.; Woodruff, W.L.

1995-02-01

The WIMSD4 code has been adopted for cross-section generation in support of the Reduced Enrichment for Research and Test (RERTR) program at Argonne National Laboratory (ANL). Subsequently, the code has undergone several updates, and significant improvements have been achieved. The capability of generating group-collapsed micro- or macroscopic cross sections from the ENDF/B-V library and the more recent evaluation, ENDF/B-VI, in the ISOTXS format makes the modified version of the WIMSD4 code, WIMSD4M, very attractive, not only for the RERTR program, but also for the reactor physics community. The intent of the present paper is to validate the procedure to generatemore » cross-section libraries for reactor analyses and calculations utilizing the WIMSD4M code. To do so, the results of calculations performed with group cross-section data generated with the WIMSD4M code will be compared against experimental results. These results correspond to calculations carried out with thermal reactor benchmarks of the Oak Ridge National Laboratory(ORNL) unreflected critical spheres, the TRX critical experiments, and calculations of a modified Los Alamos highly-enriched heavy-water moderated benchmark critical system. The benchmark calculations were performed with the discrete-ordinates transport code, TWODANT, using WIMSD4M cross-section data. Transport calculations using the XSDRNPM module of the SCALE code system are also included. In addition to transport calculations, diffusion calculations with the DIF3D code were also carried out, since the DIF3D code is used in the RERTR program for reactor analysis and design. For completeness, Monte Carlo results of calculations performed with the VIM and MCNP codes are also presented.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)

Merkley, Eric D.; Sego, Landon H.; Lin, Andy

Adaptive processes in bacterial species can occur rapidly in laboratory culture, leading to genetic divergence between naturally occurring and laboratory-adapted strains. Differentiating wild and closely-related laboratory strains is clearly important for biodefense and bioforensics; however, DNA sequence data alone has thus far not provided a clear signature, perhaps due to lack of understanding of how diverse genome changes lead to adapted phenotypes. Protein abundance profiles from mass spectrometry-based proteomics analyses are a molecular measure of phenotype. Proteomics data contains sufficient information that powerful statistical methods can uncover signatures that distinguish wild strains of Yersinia pestis from laboratory-adapted strains.
What happens with organic micropollutants during UV disinfection in WWTPs? A global perspective from laboratory to full-scale.

PubMed

Paredes, L; Omil, F; Lema, J M; Carballa, M

2018-01-15

The phototransformation of 18 organic micropollutants (OMPs) commonly detected in wastewater treatment plant (WWTP) effluents was examined attempting to explain their fate during UV disinfection in WWTPs. For this purpose, a lab-scale UV reactor (lamp emitting at 254nm) was used to study the influence of the operational conditions (UV dose, temperature and water matrix) on OMPs abatement and disinfection efficiency. Chemical properties of OMPs and the quality of treated effluent were identified as key factors affecting the phototransformation rate of these compounds. Sampling campaigns were carried out at the inlet and outlet of UV systems of three WWTPs, and the results evidenced that only the most photosensitive compounds, such as sulfamethoxazole and diclofenac, are eliminated. Therefore, despite UV treatment is an effective technology to phototransform OMPs, the UV doses typically applied for disinfection (10-50mJ/cm 2 ) are not sufficient to remove them. Consequently, small modifications (increase of UV dose, use of catalysts) should be applied in WWTPs to enhance the abatement of OMPs in UV systems. Copyright © 2017 Elsevier B.V. All rights reserved.
Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene.

PubMed

Call, Zachary; Suchewski, Meagan; Bradley, Christopher A

2017-03-20

A reliable, intermediate scale preparation of 1,2,3,4,5-pentamethylcyclopentadiene (Cp*H) is presented, based on modifications of existing protocols that derive from initial 2-bromo-2-butene lithiation followed by acid mediated dienol cyclization. The revised synthesis and purification of the ligand avoids the use of mechanical stirring while still permitting access to significant quantities (39 g) of Cp*H in good yield (58%). The procedure offers other additional benefits, including a more controlled quench of excess lithium during the production of the intermediate heptadienols and a simplified isolation of Cp*H of sufficient purity for metallation with transition metals. The ligand was subsequently used to synthesize [Cp*MCl2]2 complexes of both iridium and ruthenium to demonstrate the utility of the Cp*H prepared and purified by our method. The procedure outlined herein affords substantial quantities of a ubiquitous ancillary ligand support used in organometallic chemistry while minimizing the need for specialized laboratory equipment, thus providing a simpler and more accessible entry point into the chemistry of 1,2,3,4,5-pentamethylcyclopentadiene.
Results of isolated lateral retinacular reconstruction for iatrogenic medial patellar instability.

PubMed

Sanchis-Alfonso, Vicente; Montesinos-Berry, Erik; Monllau, Joan Carles; Merchant, Alan C

2015-03-01

The aim of this study was to assess the outcomes of an isolated lateral retinaculum reconstruction for iatrogenic medial patellar instability (IMPI) in patients with continued pain after failed lateral retinacular release (LRR), including associated psychometric analysis. Pain was assessed using the visual analog scale (VAS) and disability was determined with the Lysholm scale. Psychological variables such as anxiety, depression, catastrophizing, and fear-of-movement beliefs were studied by using self-administered psychometric questionnaires. All 17 patients (13 women and 4 men) in this retrospective study had undergone LRR previously for anterior knee pain or lateral patellar instability. Four patients had undergone LRR plus proximal (Insall) realignment, and one had undergone LRR plus a medial tibial tubercle transfer. After their procedures, all had disabling symptoms. All patients underwent reconstructive surgery for IMPI. At a minimum follow-up of 2 years (range, 2 to 8 years), the mean preoperative VAS score was 7.6 (range, 5 to 9) and improved to 1.9 (range, 0 to 8) at the time of final follow-up (P < .001). The mean preoperative Lysholm score was 36.4 (range, 20 to 55), and the knee was described as bad (<65 points) in all cases. Postoperatively, it improved to 86.1 (range, 70 to 94) at final follow-up (P < .001). Before surgery, 4 patients (24%) had the clinical criteria for depression, 10 (59%) had anxiety, 7 (41%) had "catastrophizing" ideas concerning pain, and all (100%) had kinesiophobia (fear of movement). After surgery, none of the patients had depression or anxiety, none had catastrophizing ideation, and only 53% had kinesiophobia. Reconstruction of the deep transverse layer of the lateral retinaculum (LR) using a central strip of the iliotibial band for IMPI in patients with continued pain after failed LRR can successfully treat these severely disabled patients. Level IV, therapeutic case series. Copyright © 2015 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
Laboratory studies to characterize the efficacy of sand capping a coal tar-contaminated sediment.

PubMed

Hyun, Seunghun; Jafvert, Chad T; Lee, Linda S; Rao, P Suresh C

2006-06-01

Placement of a microbial active sand cap on a coal tar-contaminated river sediment has been suggested as a cost effective remediation strategy. This approach assumes that the flux of contaminants from the sediment is sufficiently balanced by oxygen and nutrient fluxes into the sand layer such that microbial activity will reduce contaminant concentrations within the new benthic zone and reduce the contaminant flux to the water column. The dynamics of such a system were evaluated using batch and column studies with microbial communities from tar-contaminated sediment under different aeration and nutrient inputs. In a 30-d batch degradation study on aqueous extracts of coal tar sediment, oxygen and nutrient concentrations were found to be key parameters controlling the degradation rates of polycyclic aromatic hydrocarbons (PAHs). For the five PAHs monitored (naphthalene, fluorene, phenanthrene, anthracene, and pyrene), degradation rates were inversely proportional to molecular size. For the column studies, where three columns were packed with a 20-cm sand layer on the top of a 5 cm of sediment layer, flow was established to sand layers with (1) aerated water, (2) N(2) sparged water, or (3) HgCl(2)-sterilized N(2) sparged water. After steady-state conditions, PAH concentrations in effluents were the lowest in the aerated column, except for pyrene, whose concentration was invariant with all effluents. These laboratory scale studies support that if sufficient aeration can be achieved in the field through either active and passive means, the resulting microbially active sand layer can improve the water quality of the benthic zone and reduce the flux of many, but not all, PAHs to the water column.
Fracture induced electromagnetic emissions: extending laboratory findings by observations at the geophysical scale

NASA Astrophysics Data System (ADS)

Potirakis, Stelios M.; Contoyiannis, Yiannis; Kopanas, John; Kalimeris, Anastasios; Antonopoulos, George; Peratzakis, Athanasios; Eftaxias, Konstantinos; Nomicos, Constantinos

2014-05-01

Under natural conditions, it is practically impossible to install an experimental network on the geophysical scale using the same instrumentations as in laboratory experiments for understanding, through the states of stress and strain and their time variation, the laws that govern the friction during the last stages of EQ generation, or to monitor (much less to control) the principal characteristics of a fracture process. Fracture-induced electromagnetic emissions (EME) in a wide range of frequency bands are sensitive to the micro-structural chances. Thus, their study constitutes a nondestructive method for the monitoring of the evolution of damage process at the laboratory scale. It has been suggested that fracture induced MHz-kHz electromagnetic (EM) emissions, which emerge from a few days up to a few hours before the main seismic shock occurrence permit a real time monitoring of the damage process during the last stages of earthquake preparation, as it happens at the laboratory scale. Since the EME are produced both in the case of the laboratory scale fracture and the EQ preparation process (geophysical scale fracture) they should present similar characteristics in these two scales. Therefore, both the laboratory experimenting scientists and the experimental scientists studying the pre-earthquake EME could benefit from each- other's results. Importantly, it is noted that when studying the fracture process by means of laboratory experiments, the fault growth process normally occurs violently in a fraction of a second. However, a major difference between the laboratory and natural processes is the order-of-magnitude differences in scale (in space and time), allowing the possibility of experimental observation at the geophysical scale for a range of physical processes which are not observable at the laboratory scale. Therefore, the study of fracture-induced EME is expected to reveal more information, especially for the last stages of the fracture process, when it is conducted at the geophysical scale. As a characteristic example, we discuss about the case of electromagnetic silence before the global rupture that was first observed in preseismic EME and recently was also observed in the EME measured during laboratory fracture experiments, completely revising the earlier views about the fracture-induced electromagnetic emissions.
The toxicity of creosote-treated wood to Pacific herring embryos and characterization of polycyclic aromatic hydrocarbons near creosoted pilings in Juneau, Alaska.

PubMed

Duncan, Danielle L; Carls, Mark G; Rice, Stanley D; Stekoll, Michael S

2017-05-01

Polycyclic aromatic hydrocarbons (PAHs) from creosote exposure in the laboratory resulted in deleterious effects in developing Pacific herring (Clupea pallasi) embryos, and potentially toxic concentrations of PAHs were measured using passive water samplers at 1 of 3 harbor field sites in Juneau, Alaska, USA. Aqueous total PAH concentrations of 4.6 μg/L and 8.4 μg/L from creosote exposure resulted in skeletal defects and ineffective swimming in hatched larvae in the laboratory (10% effective concentrations) and were the most sensitive parameters measured. Hatch rates also suffered from creosote exposure in a dose-dependent manner: at exposures between 5 μg/L and 50 μg/L total PAH, 50% of the population failed to hatch. Comparisons between laboratory and field deployed passive samplers suggested that for at least 1 harbor in Juneau, concentrations sufficient to induce teratogenic effects were found directly on creosoted pilings, within 10 cm of them, and sometimes at a distance of 10 m. Total PAH concentrations generally decreased with distance from creosoted pilings. Creosote pilings contribute to the PAH load within a marina and can rise to PAH concentrations that are harmful to fish embryos, but at a scale that is localized in the environment. Environ Toxicol Chem 2017;36:1261-1269. © 2016 SETAC. © 2016 SETAC.
PASSIM--an open source software system for managing information in biomedical studies.

PubMed

Viksna, Juris; Celms, Edgars; Opmanis, Martins; Podnieks, Karlis; Rucevskis, Peteris; Zarins, Andris; Barrett, Amy; Neogi, Sudeshna Guha; Krestyaninova, Maria; McCarthy, Mark I; Brazma, Alvis; Sarkans, Ugis

2007-02-09

One of the crucial aspects of day-to-day laboratory information management is collection, storage and retrieval of information about research subjects and biomedical samples. An efficient link between sample data and experiment results is absolutely imperative for a successful outcome of a biomedical study. Currently available software solutions are largely limited to large-scale, expensive commercial Laboratory Information Management Systems (LIMS). Acquiring such LIMS indeed can bring laboratory information management to a higher level, but often implies sufficient investment of time, effort and funds, which are not always available. There is a clear need for lightweight open source systems for patient and sample information management. We present a web-based tool for submission, management and retrieval of sample and research subject data. The system secures confidentiality by separating anonymized sample information from individuals' records. It is simple and generic, and can be customised for various biomedical studies. Information can be both entered and accessed using the same web interface. User groups and their privileges can be defined. The system is open-source and is supplied with an on-line tutorial and necessary documentation. It has proven to be successful in a large international collaborative project. The presented system closes the gap between the need and the availability of lightweight software solutions for managing information in biomedical studies involving human research subjects.
Minimally Invasive Surgery for Tibiotalocalcaneal Arthrodesis Using a Retrograde Intramedullary Nail: Preliminary Results of an Innovative Modified Technique.

PubMed

Biz, Carlo; Hoxhaj, Bramir; Aldegheri, Roberto; Iacobellis, Claudio

The aim of the present longitudinal prospective study was to evaluate the clinical, functional, and radiologic outcomes and patient satisfaction of those who had undergone minimally invasive surgery (MIS) for tibiotalocalcaneal arthrodesis with an intramedullary nail. The 28 patients, who had consecutively undergone surgery with the MIS technique, were evaluated clinically and radiographically at 1, 2, 3, and 6 months after surgery and at last follow-up examination. For the clinical evaluation, the American Orthopaedic Foot and Ankle Society scale and visual analog scale for the foot and ankle were used in the preoperative and final follow-up examinations. The patients rated their satisfaction on a scale from 0 to 10. The mean score obtained with the American Orthopaedic Foot and Ankle Society scale was 68.28 ± 5.02 (range 58 to 74) points and with the visual analog scale for the foot and ankle was 70.76 ± 7.72 (range 58 to 82) points, with a mean follow-up of 25.07 ± 6.32 (range 6 to 40) months. The clinical improvement was statistically significant with both types of evaluation (p ≤ .05), comparing the preoperative and follow-up periods. Fusion was achieved in all patients, with a mean fusion time of 14.85 ± 4.12 (range 8 to 56) weeks. The alignment of the ankle and foot was optimal in 27 of 28 patients (96.42%), and patient satisfaction was rated as 6.71 ± 1.37 (range 5 to 10) points. Finally, the use of MIS for tibiotalocalcaneal arthrodesis with intramedullary nail results in fusion of the articulation with a low complication rate. Copyright © 2016 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
Biology of the rabbit.

PubMed

Brewer, Nathan R

2006-01-01

In recognition of Dr. Nathan Brewer's many years of dedicated service to AALAS and the community of research animal care specialists, the premier issue of JAALAS includes the following compilation of Dr. Brewer's essays on rabbit anatomy and physiology. These essays were originally published in the ASLAP newsletter (formerly called Synapse), and are reprinted here with the permission and endorsement of that organization. I would like to thank Nina Hahn, Jane Lacher, and Nancy Austin for assistance in compiling these essays. Publishing this information in JAALAS allows Dr. Brewer's work to become part of the searchable literature for laboratory animal science and medicine and also assures that the literature references and information he compiled will not be lost to posterity. However, readers should note that this material has undergone only minor editing for style, has not been edited for content, and, most importantly, has not undergone peer review. With the agreement of the associate editors and the AALAS leadership, I elected to forego peer review of this work, in contradiction to standard JAALAS policy, based on the status of this material as pre-published information from an affiliate organization that holds the copyright and on the esteem in which we hold for Dr. Brewer as a founding father of our organization.
Laboratory study of adsorption and deliquescence on the surface of Mars

NASA Astrophysics Data System (ADS)

Nikolakakos, George; Whiteway, James A.

2018-07-01

A sample of the zeolitic mineral chabazite was subjected to a range of water vapor pressures and temperatures found on present day Mars. Laser Raman scattering was applied to detect the relative amounts of water and carbon dioxide adsorbed by the sample. Results show that zeolites are capable of adsorbing water from the atmosphere on diurnal time scales and that Raman scattering spectroscopy provides a promising method for detecting this process during a landed mission. When the water vapor pressure and temperature were sufficiently low, the zeolite sample also adsorbed carbon dioxide, resulting in the simultaneous adsorption of water and carbon dioxide on the surface mineral grains. Additional experiments were carried out using a mixture of magnesium perchlorate and chabazite. The sample of mixed surface material remained visually unchanged during water adsorption, but was found to darken during deliquescence.
Rates of CO2 Mineralization in Geological Carbon Storage.

PubMed

Zhang, Shuo; DePaolo, Donald J

2017-09-19

Geologic carbon storage (GCS) involves capture and purification of CO 2 at industrial emission sources, compression into a supercritical state, and subsequent injection into geologic formations. This process reverses the flow of carbon to the atmosphere with the intention of returning the carbon to long-term geologic storage. Models suggest that most of the injected CO 2 will be "trapped" in the subsurface by physical means, but the most risk-free and permanent form of carbon storage is as carbonate minerals (Ca,Mg,Fe)CO 3 . The transformation of CO 2 to carbonate minerals requires supply of the necessary divalent cations by dissolution of silicate minerals. Available data suggest that rates of transformation are highly uncertain and difficult to predict by standard approaches. Here we show that the chemical kinetic observations and experimental results, when they can be reduced to a single cation-release time scale that describes the fractional rate at which cations are released to solution by mineral dissolution, show sufficiently systematic behavior as a function of pH, fluid flow rate, and time that the rates of mineralization can be estimated with reasonable certainty. The rate of mineralization depends on both the abundance (determined by the reservoir rock mineralogy) and the rate at which cations are released from silicate minerals by dissolution into pore fluid that has been acidified with dissolved CO 2 . Laboratory-measured rates and field observations give values spanning 8 to 10 orders of magnitude, but when they are evaluated in the context of a reservoir-scale reactive transport simulation, this range becomes much smaller. The reservoir scale simulations provide limits on the applicable conditions under which silicate mineral dissolution and subsequent carbonate mineral precipitation are likely to occur (pH 4.5 to 6, fluid flow velocity less than 5 m/year, and 50-100 years or more after the start of injection). These constraints lead to estimates of 200 to 2000 years for conversion of 60-90% of injected CO 2 when the reservoir rock has a sufficient volume fraction of divalent cation-bearing silicate minerals and confirms that when reservoir rock mineralogy is not favorable the fraction of CO 2 converted to carbonate minerals is minimal over 10 4 years. A sufficient amount of reactive minerals is typically about 20% by volume. Our approach may allow for rapid evaluation of mineralization potential of subsurface storage reservoirs and illustrates how reservoir scale modeling can be integrated with other observations to address key issues relating to engineering of geologic systems.
30 CFR 14.21 - Laboratory-scale flame test apparatus.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the apparatus...

30 CFR 14.21 - Laboratory-scale flame test apparatus.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Laboratory-scale flame test apparatus. 14.21 Section 14.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... Technical Requirements § 14.21 Laboratory-scale flame test apparatus. The principal parts of the apparatus...
Quality Assessment of Physical and Organoleptic Instant Corn Rice on Scale-Up Process

NASA Astrophysics Data System (ADS)

Kumalasari, R.; Ekafitri, R.; Indrianti, N.

2017-12-01

Development of instant corn rice product has been successfully conducted on a laboratory scale. Corn has high carbohydrate content but low in fiber. The addition of fiber in instant corn rice, intended to improve the functioning of the product, and replace fiber loss during the process. Scale up process of Instant corn rice required to increase the production capacity. Scale up was the process to get identic output on a larger scale based on predetermined production scale. This study aimed to assess the changes and differences in the quality of instant corn rice during scale up. Instant corn rice scale up was done on production capacity 3 kg, 4 kg and 5 kg. Results showed that scale up of instant corn rice producing products with rehydration ratio ranges between 514% - 570%, the absorption rate ranged between 414% - 470%, swelling rate ranging between 119% - 134%, bulk density ranged from 0.3661 to 0.4745 (g/ml) and porosity ranging between 30-37%. The physical quality of instant corn rice on scale up were stable from the ones at laboratory scale on swelling rate, rehydration ratio, and absorption rate but not stable on bulk density and porosity. Organoleptic qualities were stable at increased scale compared on a laboratory scale. Bulk density was higher than those at laboratory scale, and the porosity was lower than those at laboratory scale.
PILOT-SCALE REMOVAL OF FLUORIDE FROM LEGACY PLUTONIUM MATERIALS USING VACUUM SALT DISTILLATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, R. A.; Pak, D. J.

2012-09-11

Between September 2009 and January 2011, the Savannah River National Laboratory (SRNL) and HB-Line designed, developed, tested, and successfully deployed a system for the distillation of chloride salts. In 2011, SRNL adapted the technology for the removal of fluoride from fluoride-bearing salts. The method involved an in situ reaction between potassium hydroxide (KOH) and the fluoride salt to yield potassium fluoride (KF) and the corresponding oxide. The KF and excess KOH can be distilled below 1000{deg}C using vacuum salt distillation (VSD). The apparatus for vacuum distillation contains a zone heated by a furnace and a zone actively cooled using eithermore » recirculated water or compressed air. During a vacuum distillation operation, a sample boat containing the feed material is placed into the apparatus while it is cool, and the system is sealed. The system is evacuated using a vacuum pump. Once a sufficient vacuum is attaned, heating begins. Volatile salts distill from the heated zone to the cooled zone where they condense, leaving behind the non-volatile material in the feed boat. Studies discussed in this report were performed involving the use of non-radioactive simulants in small-scale and pilot-scale systems as well as radioactive testing of a small-scale system with plutonium-bearing materials. Aspects of interest include removable liner design considerations, boat materials, in-line moisture absorption, and salt deposition.« less
Results of operative treatment of the pectus carinatum.

PubMed

Nowacki, Wiesław; Kruczyński, Jacek; Futyma, Jacek; Stencel, Piotr

2008-01-01

Evaluation of the efficiency of the operative treatment for pectus carinatum depending on the type of deformity. 65 subjects following surgical procedures due to pectus carinatum deformity between 1997 and 2003 were analyzed. Surgical correction of the deformity depended on the localization of the sternal protrusion, grade of asymmetry and severity of the deformity. Radiological severity index of the deformity (Haller's index-HI) and patients' subjective evaluation were collected to assess the grade of deformity and the results of treatment. Very good or good results were achieved after a mean period of 38 months of follow-up in all subjects who undergone surgical procedure. It was proven that stabilization of the osteotomy sternum site with a non-absorbable suture sufficiently enough protects against relapses of the malformation and hypercorrection.
Simplified models of rates of CO2 mineralization in Geologic Carbon Storage

NASA Astrophysics Data System (ADS)

DePaolo, D. J.; Zhang, S.

2017-12-01

Geologic carbon storage (GCS) reverses the flow of carbon to the atmosphere, returning the carbon to long-term geologic storage. Models suggest that most of the injected CO2 will be "trapped" in the subsurface by physical means, but the most risk-free and permanent form of carbon storage is as carbonate minerals (Ca,Mg,Fe)CO3. The transformation of CO2 to carbonate minerals requires supply of divalent cations by dissolution of silicate minerals. Available data suggest that rates of transformation are difficult to predict. We show that the chemical kinetic observations and experimental results, when reduced to a single timescale that describes the fractional rate at which cations are released to solution by mineral dissolution, show sufficiently systematic behavior that the rates of mineralization can be estimated with reasonable certainty. Rate of mineralization depends on both the abundance (determined by the reservoir rock mineralogy) and the rate at which cations are released by dissolution into pore fluid that has been acidified with dissolved CO2. Laboratory-measured rates and field observations give values spanning 8 to 10 orders of magnitude, but when evaluated in the context of reservoir-scale reactive transport simulations, this range becomes much smaller. Reservoir scale simulations indicate that silicate mineral dissolution and subsequent carbonate mineral precipitation occur at pH 4.5 to 6, fluid flow velocity less than 5m/yr, and 50-100 years or more after the start of injection. These constraints lead to estimates of 200 to 2000 years for conversion of 60-90% of injected CO2 when the reservoir rock has a sufficient volume fraction of divalent cation-bearing silicate minerals (ca. 20%), and confirms that when reservoir rock mineralogy is not favorable the fraction of CO2 converted to carbonate minerals is minimal over 104 years. A sufficient amount of reactive minerals represents the condition by which the available cations per volume of rock plus pore space exceeds the locally trapped CO2 by a factor of two or more. Our approach may allow for rapid evaluation of mineralization potential of subsurface storage reservoirs, and illustrates how reservoir scale modeling can be integrated with other observations to address key issues for engineering geologic systems.
The Preoperative Composite Physiologic Index May Predict Mortality in Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema.

PubMed

Ueno, Fumika; Kitaguchi, Yoshiaki; Shiina, Takayuki; Asaka, Shiho; Miura, Kentaro; Yasuo, Masanori; Wada, Yosuke; Yoshizawa, Akihiko; Hanaoka, Masayuki

2017-01-01

It remains unclear whether the preoperative pulmonary function parameters and prognostic indices that are indicative of nutritional and immunological status are associated with prognosis in lung cancer patients with combined pulmonary fibrosis and emphysema (CPFE) who have undergone surgery. The aim of this study is to identify prognostic determinants in these patients. The medical records of all patients with lung cancer associated with CPFE who had undergone surgery at Shinshu University Hospital were retrospectively reviewed to obtain clinical data, including the results of preoperative pulmonary function tests and laboratory examinations, chest high-resolution computed tomography (HRCT), and survival. Univariate Cox proportional hazards regression analysis showed that a high pathological stage of the lung cancer, a higher preoperative serum carcinoembryonic antigen level, and a higher preoperative composite physiologic index (CPI) were associated with a high risk of death. Multivariate analysis showed that a high pathological stage of the lung cancer (HR: 1.579; p = 0.0305) and a higher preoperative CPI (HR: 1.034; p = 0.0174) were independently associated with a high risk of death. In contrast, the severity of fibrosis or emphysema on chest HRCT, the individual pulmonary function parameters, the prognostic nutritional index, the neutrophil-to-lymphocyte ratio, and the platelet-to-lymphocyte ratio were not associated with prognosis. In the Kaplan-Meier analysis, the log-rank test showed significant differences in survival between the high-CPI and the low-CPI group (p = 0.0234). The preoperative CPI may predict mortality and provide more powerful prognostic information than individual pulmonary function parameters in lung cancer patients with CPFE who have undergone surgery. © 2017 S. Karger AG, Basel.
EPOS-WP16: A Platform for European Multi-scale Laboratories

NASA Astrophysics Data System (ADS)

Spiers, Chris; Drury, Martyn; Kan-Parker, Mirjam; Lange, Otto; Willingshofer, Ernst; Funiciello, Francesca; Rosenau, Matthias; Scarlato, Piergiorgio; Sagnotti, Leonardo; W16 Participants

2016-04-01

The participant countries in EPOS embody a wide range of world-class laboratory infrastructures ranging from high temperature and pressure experimental facilities, to electron microscopy, micro-beam analysis, analogue modeling and paleomagnetic laboratories. Most data produced by the various laboratory centres and networks are presently available only in limited "final form" in publications. As such many data remain inaccessible and/or poorly preserved. However, the data produced at the participating laboratories are crucial to serving society's need for geo-resources exploration and for protection against geo-hazards. Indeed, to model resource formation and system behaviour during exploitation, we need an understanding from the molecular to the continental scale, based on experimental data. This contribution will describe the work plans that the laboratories community in Europe is making, in the context of EPOS. The main objectives are: - To collect and harmonize available and emerging laboratory data on the properties and processes controlling rock system behaviour at multiple scales, in order to generate products accessible and interoperable through services for supporting research activities. - To co-ordinate the development, integration and trans-national usage of the major solid Earth Science laboratory centres and specialist networks. The length scales encompassed by the infrastructures included range from the nano- and micrometer levels (electron microscopy and micro-beam analysis) to the scale of experiments on centimetre sized samples, and to analogue model experiments simulating the reservoir scale, the basin scale and the plate scale. - To provide products and services supporting research into Geo-resources and Geo-storage, Geo-hazards and Earth System Evolution.
[Development of a Japanese version of the TALE scale].

PubMed

Ochiai, Tsutomu; Oguchi, Takashi

2013-12-01

The Thinking About Life Experiences (TALE) Scale (Bluck & Alea, 2011) has three subscales that assess the self, social, and directive functions of autobiographical memory. This study constructs a Japanese version of the TALE Scale and examines its reliability and validity. Fifteen items that assess the three functions of autobiographical memory were translated into Japanese. We conducted an online investigation with 600 men and women between 20-59 years of age. In Study 1, exploratory and confirmatory factor analysis identified that the three-factor structure of the Japanese version of the TALE Scale was the same as the original TALE Scale. Sufficient internal consistency of the scale was found, and the construct validity of the scale was supported by correlation analysis. Study 2 confirmed that the test-retest reliabilities of the three subscales were sufficient. Thus, this Japanese version of the TALE Scale is useful to assess autobiographical memory functions in Japan.
Comparison of one-dimensional probabilistic finite element method with direct numerical simulation of dynamically loaded heterogeneous materials

NASA Astrophysics Data System (ADS)

Robbins, Joshua; Voth, Thomas

2011-06-01

Material response to dynamic loading is often dominated by microstructure such as grain topology, porosity, inclusions, and defects; however, many models rely on assumptions of homogeneity. We use the probabilistic finite element method (WK Liu, IJNME, 1986) to introduce local uncertainty to account for material heterogeneity. The PFEM uses statistical information about the local material response (i.e., its expectation, coefficient of variation, and autocorrelation) drawn from knowledge of the microstructure, single crystal behavior, and direct numerical simulation (DNS) to determine the expectation and covariance of the system response (velocity, strain, stress, etc). This approach is compared to resolved grain-scale simulations of the equivalent system. The microstructures used for the DNS are produced using Monte Carlo simulations of grain growth, and a sufficient number of realizations are computed to ensure a meaningful comparison. Finally, comments are made regarding the suitability of one-dimensional PFEM for modeling material heterogeneity. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.
Simulation and Preliminary Design of a Cold Stream Experiment on Omega EP

NASA Astrophysics Data System (ADS)

Coffing, Shane; Angulo, Adrianna; Trantham, Matt; Malamud, Guy; Kuranz, Carolyn; Drake, R. P.

2017-10-01

Galaxies form within dark matter halos, accreting gas that may clump and eventually form stars. Infalling matter gradually increases the density of the halo, and, if cooling is insufficient, rising pressure forms a shock that slows the infalling gas, reducing star formation. However, galaxies with sufficient cooling become prolific star formers. A recent theory suggests that so called ``stream fed galaxies'' are able to acquire steady streams of cold gas via galactic ``filaments'' that penetrate the halo. The cold, dense filament flowing into a hot, less dense environment is potentially Kelvin-Helmholtz unstable. This instability may hinder the ability of the stream to deliver gas deeply enough into the halo. To study this process, we have begun preliminary design of a well-scaled laser experiment on Omega EP. We present here early simulation results and the physics involved. This work is funded by the U.S. Department of Energy, through the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, Grant Number DE-NA0002956, and the National Laser User Facility Program, Grant Number DE-NA0002719, and through the Laboratory for Laser Energetics, University of Rochester by the NNSA/OICF under Cooperative Agreement No. DE-NA0001944.
Laboratory, semi-pilot and room scale study of nitrite and molybdate mediated control of H(2)S emission from swine manure.

PubMed

Moreno, Lyman; Predicala, Bernardo; Nemati, Mehdi

2010-04-01

The effects of manure age on emission of H(2)S and required level of nitrite or molybdate to control these emissions were investigated in the present work. Molybdate mediated control of H(2)S emission was also studied in semi-pilot scale open systems, and in specifically designed chambers which simulated swine production rooms. With fresh 1-, 3- and 6-month old manures average H(2)S concentration in the headspace gas of the closed systems were 4856+/-460, 3431+/-208, 1037+/-98 ppm and non-detectable, respectively. Moreover, the level of nitrite or molybdate required to control the emission of H(2)S decreased as manure age increased. In the semi-pilot scale open system and chambers, average H(2)S concentration at the surface of agitated fresh manure were 831+/-26 and 88.4+/-5.7 ppm, respectively. Furthermore, 0.1-0.25 mM molybdate was sufficient to control the emission of H(2)S. A cost study for an average size swine operation showed that the cost of treatment with molybdate was less than 1% of the overall production cost for each market hog. Copyright 2009 Elsevier Ltd. All rights reserved.
Biotechnologies for critical raw material recovery from primary and secondary sources: R&D priorities and future perspectives.

PubMed

Hennebel, Tom; Boon, Nico; Maes, Synthia; Lenz, Markus

2015-01-25

Europe is confronted with an increasing supply risk of critical raw materials. These can be defined as materials of which the risks of supply shortage and their impacts on the economy are higher compared to most of other raw materials. Within the framework of the EU Innovation Partnership on raw materials Initiative, a list of 14 critical materials was defined, including some bulk metals, industrial minerals, the platinum group metals and rare earth elements. To tackle the supply risk challenge, innovation is required with respect to sustainable primary mining, substitution of critical metals, and urban mining. In these three categories, biometallurgy can play a crucial role. Indeed, microbe-metal interactions have been successfully applied on full scale to win materials from primary sources, but are not sufficiently explored for metal recovery or recycling. On the one hand, this article gives an overview of the microbial strategies that are currently applied on full scale for biomining; on the other hand it identifies technologies, currently developed in the laboratory, which have a perspective for large scale metal recovery and the needs and challenges on which bio-metallurgical research should focus to achieve this ambitious goal. Copyright © 2013. Published by Elsevier B.V.
Comparing field investigations with laboratory models to predict landfill leachate emissions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fellner, Johann; Doeberl, Gernot; Allgaier, Gerhard

2009-06-15

Investigations into laboratory reactors and landfills are used for simulating and predicting emissions from municipal solid waste landfills. We examined water flow and solute transport through the same waste body for different volumetric scales (laboratory experiment: 0.08 m{sup 3}, landfill: 80,000 m{sup 3}), and assessed the differences in water flow and leachate emissions of chloride, total organic carbon and Kjeldahl nitrogen. The results indicate that, due to preferential pathways, the flow of water in field-scale landfills is less uniform than in laboratory reactors. Based on tracer experiments, it can be discerned that in laboratory-scale experiments around 40% of pore watermore » participates in advective solute transport, whereas this fraction amounts to less than 0.2% in the investigated full-scale landfill. Consequences of the difference in water flow and moisture distribution are: (1) leachate emissions from full-scale landfills decrease faster than predicted by laboratory experiments, and (2) the stock of materials remaining in the landfill body, and thus the long-term emission potential, is likely to be underestimated by laboratory landfill simulations.« less
Shock structures at ultrahigh strain rates: what can they tell us about material behavior on very fast time scales?

NASA Astrophysics Data System (ADS)

Crowhurst, Jonathan

2013-06-01

In recent years, techniques based on table-top laser systems have shown promise for investigating dynamic material behavior at high rates of both compressive and tensile strain. Common to these techniques is a laser pulse that is used in some manner to rapidly deliver energy to the sample; while the energy itself is often comparatively very small, the intensity can be made high by tightly focusing the pump light. In this way pressures or stresses can be obtained that are sufficiently large to have relevance to a wide range of basic and applied fields. Also, when combined with established ultrafast diagnostics these experiments provide very high time resolution which is particularly desirable when studying, for example shock waves, in which the time for the material to pass from undisturbed to fully compressed (the ``rise time'') can be extremely short (order 10 ps or less) even at fairly small peak stresses. Since much of the most interesting physics comes into play during this process it is important to be able to adequately resolve the shock rise. In this context I will discuss our measurements on aluminum and iron thin films and compare the results with known behavior observed at lower strain rates. Specifically, for aluminum, I will compare our assumed steady wave data at strain rates of up to 1010 s-1 to literature data up to ~107 s-1 and show that the well-known fourth power scaling relation of strain rate to shock stress is maintained even at these very high strain rates. For iron, I will show how we have used our nonsteady data (up to ~109 s-1) to infer a number of important properties of the alpha to epsilon polymorphic transition: 1. The transition can occur on the tens of ps time scale at sufficiently high strain rates and corresponding very large deviatoric stresses, and 2, most of the material appears to transform at a substantially higher stress than the nominal value usually inferred from shock wave experiments of about 13 GPa. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344 with Laboratory directed Research and Development funding (12ERD042), as well as being based on work supported as part of the EFree, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award No. DESC0001057.
2011 investigation of internal contamination with radioactive strontium following rubidium Rb 82 cardiac PET scan.

PubMed

Pillai, Satish K; Chang, Arthur; Murphy, Matthew W; Buzzell, Jennifer; Ansari, Armin; Whitcomb, Robert C; Miller, Charles; Jones, Robert; Saunders, David P; Cavicchia, Philip; Watkins, Sharon M; Blackmore, Carina; Williamson, John A; Stephens, Michael; Morrison, Melissa; McNees, James; Murphree, Rendi; Buchanan, Martha; Hogan, Anthony; Lando, James; Nambiar, Atmaram; Torso, Lauren; Melnic, Joseph M; Yang, Lucie; Lewis, Lauren

2014-01-01

During routine screening in 2011, US Customs and Border Protection (CBP) identified 2 persons with elevated radioactivity. CBP, in collaboration with Los Alamos National Laboratory, informed the Food and Drug Administration (FDA) that these people could have increased radiation exposure as a result of undergoing cardiac Positron Emission Tomography (PET) scans several months earlier with rubidium Rb 82 chloride injection from CardioGen-82. We conducted a multistate investigation to assess the potential extent and magnitude of radioactive strontium overexposure among patients who had undergone Rb 82 PET scans. We selected a convenience sample of clinical sites in 4 states and reviewed records to identify eligible study participants, defined as people who had had an Rb 82 PET scan between February and July 2011. All participants received direct radiation screening using a radioisotope identifier able to detect the gamma energy specific for strontium-85 (514 keV) and urine bioassay for excreted radioactive strontium. We referred a subset of participants with direct radiation screening counts above background readings for whole body counting (WBC) using a rank ordering of direct radiation screening. The rank order list, from highest to lowest, was used to contact and offer voluntary enrollment for WBC. Of 308 participants, 292 (95%) had direct radiation screening results indistinguishable from background radiation measurements; 261 of 265 (98%) participants with sufficient urine for analysis had radioactive strontium results below minimum detectable activity. None of the 23 participants who underwent WBC demonstrated elevated strontium activity above levels associated with routine use of the rubidium Rb 82 generator. Among investigation participants, we did not identify evidence of strontium internal contamination above permissible levels. This investigation might serve as a model for future investigations of radioactive internal contamination incidents.
EFFECTS OF LARVAL STOCKING DENSITY ON LABORATORY-SCALE AND COMMERICAL-SCALE PRODUCTION OF SUMMER FLOUNDER, PARALICHTHYS DENTATUS

EPA Science Inventory

Three experiments investigating larval stocking densities of summer flounder from hatch to metamorphosis, Paralichthys dentatus, were conducted at laboratory-scale (75-L aquaria) and at commercial scale (1,000-L tanks). Experiments 1 and 2 at commercial scale tested the densities...
DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, T. E.; Nash, C. A.

It is desired to recover Cm-244 through Cm-248 from dissolved Mark-18A targets following anion exchange processing to remove the Pu. The Cm will be sent to Oak Ridge National Laboratory (ORNL) for additional R&D. Approximately 5-8 L per quarter of a Mark-18A target will have undergone anion exchange treatment and will contain Cm. A significant portion of this volume of anion exchange raffinate solution is dissolved fission products not desired to be recovered which could be sent to waste. To reduce the amount of material being sent to ORNL, a waste and volume minimization strategy was developed and is describedmore » in this report.« less
Eclipsing binary stars in the era of massive surveys First results and future prospects

NASA Astrophysics Data System (ADS)

Papageorgiou, Athanasios; Catelan, Márcio; Ramos, Rodrigo Contreras; Drake, Andrew J.

2017-09-01

Our thinking about eclipsing binary stars has undergone a tremendous change in the last decade. Eclipsing binary stars are one of nature's best laboratories for determining the fundamental physical properties of stars and thus for testing the predictions of theoretical models. Some of the largest ongoing variable star surveys include the Catalina Real-time Transient Survey (CRTS) and the VISTA Variables in the Vía Láctea survey (VVV). They both contain a large amount of photometric data and plenty of information about eclipsing binaries that wait to be extracted and exploited. Here we briefly describe our efforts in this direction.
Comprehensive visualization of paresthesia in breast cancer survivors.

PubMed

Jud, Sebastian M; Hatko, Reinhard; Maihöfner, Christian; Bani, Mayada R; Schrauder, Michael G; Lux, Michael P; Beckmann, Matthias W; Bani, Gassan; Eder, Irina; Fasching, Peter A; Loehberg, Christian R; Rauh, Claudia; Hein, Alexander

2014-07-01

As breast cancer survivors are benefiting increasingly from advanced forms of therapy, the side effects of locoregional treatment in the adjuvant setting are becoming more and more important. This article presents a new method of assessing the spatial distribution of paresthesia in breast cancer survivors after different locoregional treatments. A structured questionnaire assessing paresthesia, with body pictograms for marking paresthesia areas, was completed by 343 breast cancer survivors. The image information was digitized, generating gray-scale summation images with numbers from 0, indicating black (100 % of the patients had paresthesia), to 255, indicating white (none had paresthesia). The resulting map visualization showed the locations of paresthesia on body pictograms. The group included patients who had undergone breast-conserving surgery (BCS) and mastectomy, and also patients who had received percutaneous and interstitial radiation. A total of 56.5 % of the patients stated that they had paresthesia. The paresthesia areas were distributed within the range suggested by clinical experience. Most patients stated that they had paresthesia in the upper outer quadrant and axilla. Patients who had undergone mastectomy or percutaneous radiotherapy appeared to have more paresthesia on some areas of the body surface. Patients who had undergone mastectomy indicated larger areas of paresthesia than those with BCS-4,066 pixels (px) vs. 2,275 px. Radiotherapy did not appear to influence the spatial distribution of paresthesia. Paresthesia is a common symptom after breast cancer treatment. This paper describes a new method of assessing this side effect to improve and individualize treatment for it in the future.
Breast Cancer Detection

NASA Technical Reports Server (NTRS)

1976-01-01

NASA's Jet Propulsion Laboratory has come up with a technique to decrease exposure to harmful x-rays in mammographies or breast radiography. Usually, physicians make more than one exposure to arrive at an x-ray film of acceptable density. Now the same solar cells used to convert sunlight into electricity on space satellites can make a single exposure sufficient. When solar cell sensor is positioned directly beneath x-ray film, it can determine exactly when film has received sufficient radiation and has been exposed to optimum density. At that point associated electronic equipment sends signal to cut off x-ray source. Reduction of mammography to single exposures not only reduced x-ray hazard significantly, but doubled the number of patient examinations handled by one machine. The NASA laboratory used this control system at the Huntington Memorial Hospital with overwhelming success.

A cosmic superfluid phase

NASA Technical Reports Server (NTRS)

Gradwohl, Ben-Ami

1991-01-01

The universe may have undergone a superfluid-like phase during its evolution, resulting from the injection of nontopological charge into the spontaneously broken vacuum. In the presence of vortices this charge is identified with angular momentum. This leads to turbulent domains on the scale of the correlation length. By restoring the symmetry at low temperatures, the vortices dissociate and push the charges to the boundaries of these domains. The model can be scaled (phenomenologically) to very low energies, it can be incorporated in a late time phase transition and form large scale structure in the boundary layers of the correlation volumes. The novel feature of the model lies in the fact that the dark matter is endowed with coherent motion. The possibilities of identifying this flow around superfluid vortices with the observed large scale bulk motion is discussed. If this identification is possible, then the definite prediction can be made that a more extended map of peculiar velocities would have to reveal large scale circulations in the flow pattern.
Protein abundances can distinguish between naturally-occurring and laboratory strains of Yersinia pestis, the causative agent of plague

DOE PAGES

Merkley, Eric D.; Sego, Landon H.; Lin, Andy; ...

2017-08-30

Adaptive processes in bacterial species can occur rapidly in laboratory culture, leading to genetic divergence between naturally occurring and laboratory-adapted strains. Differentiating wild and closely-related laboratory strains is clearly important for biodefense and bioforensics; however, DNA sequence data alone has thus far not provided a clear signature, perhaps due to lack of understanding of how diverse genome changes lead to adapted phenotypes. Protein abundance profiles from mass spectrometry-based proteomics analyses are a molecular measure of phenotype. Proteomics data contains sufficient information that powerful statistical methods can uncover signatures that distinguish wild strains of Yersinia pestis from laboratory-adapted strains.
Necessity for Industry-Academic Economic Geology Collaborations for Energy Critical Minerals Research and Development

NASA Astrophysics Data System (ADS)

Hitzman, M.

2012-12-01

Economic geology is a highly interdisciplinary field utilizing a diverse set of petrologic, geochemical, geophysical, and tectonic data for improved scientific understanding of element migration and concentration in the crust (ore formation). A number of elements that were once laboratory curiosities now figure prominently in new energy technologies (e.g. wind turbines, solar energy collectors). If widely deployed, such technologies have the capacity to transform the way we produce, transmit, store, and conserve energy. To meet domestic and worldwide renewable energy needs these systems must be scaled from laboratory, to demonstration, to widespread deployment. Such technologies are materials intensive. If widely deployed, the elements required by these technologies will be needed in significant quantities and shortage of these "energy critical elements" could significantly inhibit the adoption of otherwise game changing energy technologies. It is imperative to better understand the geology, metallurgy, and mining engineering of critical mineral deposits if we are to sustainably develop these new technologies. There is currently no consensus among federal and state agencies, the national and international mining industry, the public, and the U.S. academic community regarding the importance of economic geology to secure sufficient energy critical elements to undertake large-scale renewable energy development. Available federal funding for critical elements focuses on downstream areas such as metallurgy, substitutions, and recycling rather than primary deposits. Undertaking the required research to discover and mine critical element deposits in an environmentally friendly manner will require significant partnering with industry due to the current lack of federal research support.
Accidental Turbulent Discharge Rate Estimation from Videos

NASA Astrophysics Data System (ADS)

Ibarra, Eric; Shaffer, Franklin; Savaş, Ömer

2015-11-01

A technique to estimate the volumetric discharge rate in accidental oil releases using high speed video streams is described. The essence of the method is similar to PIV processing, however the cross correlation is carried out on the visible features of the efflux, which are usually turbulent, opaque and immiscible. The key step in the process is to perform a pixelwise time filtering on the video stream, in which the parameters are commensurate with the scales of the large eddies. The velocity field extracted from the shell of visible features is then used to construct an approximate velocity profile within the discharge. The technique has been tested on laboratory experiments using both water and oil jets at Re ~105 . The technique is accurate to 20%, which is sufficient for initial responders to deploy adequate resources for containment. The software package requires minimal user input and is intended for deployment on an ROV in the field. Supported by DOI via NETL.
Optimizing fusion PIC code performance at scale on Cori Phase 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koskela, T. S.; Deslippe, J.

In this paper we present the results of optimizing the performance of the gyrokinetic full-f fusion PIC code XGC1 on the Cori Phase Two Knights Landing system. The code has undergone substantial development to enable the use of vector instructions in its most expensive kernels within the NERSC Exascale Science Applications Program. We study the single-node performance of the code on an absolute scale using the roofline methodology to guide optimization efforts. We have obtained 2x speedups in single node performance due to enabling vectorization and performing memory layout optimizations. On multiple nodes, the code is shown to scale wellmore » up to 4000 nodes, near half the size of the machine. We discuss some communication bottlenecks that were identified and resolved during the work.« less
Cross-cultural adaptation of the korean version of the minneapolis-manchester quality of life instrument-adolescent form.

PubMed

Park, Hyeon Jin; Yang, Hyung Kook; Shin, Dong Wook; Kim, Yoon Yi; Kim, Young Ae; Yun, Young Ho; Nam, Byung Ho; Bhatia, Smita; Park, Byung Kiu; Ghim, Thad T; Kang, Hyoung Jin; Park, Kyung Duk; Shin, Hee Young; Ahn, Hyo Seop

2013-12-01

We verified the reliability and validity of the Korean version of the Minneapolis-Manchester Quality of Life Instrument-Adolescent Form (KMMQL-AF) among Korean childhood cancer survivors. A total of 107 childhood cancer patients undergoing cancer treatment and 98 childhood cancer survivors who completed cancer treatment were recruited. To assess the internal structure of the KMMQL-AF, we performed multi-trait scaling analyses and exploratory factor analysis. Additionally, we compared each domains of the KMMQL-AF with those of the Karnofsky Performance Status Scale and the Revised Children's Manifest Anxiety Scale (RCMAS). Internal consistency of the KMMQL-AF was sufficient (Cronbach's alpha: 0.78-0.92). In multi-trait scaling analyses, the KMMQL-AF showed sufficient construct validity. The "physical functioning" domain showed moderate correlation with Karnofsky scores and the "psychological functioning" domain showed moderate-to-high correlation with the RCMAS. The KMMQL-AF discriminated between subgroups of different adolescent cancer survivors depending on treatment completion. The KMMQL-AF is a sufficiently reliable and valid instrument for measuring quality of life among Korean childhood cancer survivors.
[Cleanliness in the operating room].

PubMed

Suzuki, Toshiyasu

2010-05-01

With regard to recent findings in the cleanliness of the operating room, concerning handwashing and performing operations, the traditional method of excessive scrubbing using a brush is not effective, and handwashing using only an alcohol-containing antiseptic hand rub (rubbing method) has become common practice. Use of a brush has already been abolished in some medical institutions. In addition, sterilized water used for handwashing when performing operations has no scientific basis and use of tap water is considered sufficient. Furthermore, the concept of operating room zoning has also undergone a dramatic change. It was discovered that a layout focusing on work efficiency is more desirable than the one that follows an excessively rigid zoning pattern. One-footwear System not requiring change of shoes also has various advantages in improving the efficiency of the operation room, and this is thought to become commonplace in the future.
Radiological criteria for underground nuclear tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malik, J.S.; Brownlee, R.R.; Costa, C.F.

1981-04-01

The radiological criteria for the conduct of nuclear tests have undergone many revisions with the current criteria being 0.17 rad for uncontrolled populations and 0.5 rad for controllable populations. Their effect upon operations at the Nevada Test Site and the current off-site protective plans are reviewed for areas surrounding the Site. The few accidental releases that have occurred are used to establish estimates of probability of release and of hazard to the population. These are then put into context by comparing statistical data on other accidents and cataclysms. The guidelines established by DOE Manual Chapter MC-0524 have never been exceededmore » during the entire underground nuclear test program. The probability of real hazard to off-site populations appears to be sufficiently low as not to cause undue concern to the citizenry.« less
The contribution of area-level walkability to geographic variation in physical activity: a spatial analysis of 95,837 participants from the 45 and Up Study living in Sydney, Australia.

PubMed

Mayne, Darren J; Morgan, Geoffrey G; Jalaludin, Bin B; Bauman, Adrian E

2017-10-03

Individual-level studies support a positive relation between walkable built environments and participation in moderate-intensity walking. However, the utility of this evidence for population-level planning is less clear as it is derived at much finer spatial scales than those used for regional programming. The aims of this study were to: evaluate if individual-level relations between walkability and walking to improve health manifest at population-level spatial scales; assess the specificity of area-level walkability for walking relative to other moderate and vigorous physical activity (MVPA); describe geographic variation in walking and other MVPA; and quantify the contribution of walkability to this variation. Data on sufficient walking, sufficient MVPA, and high MVPA to improve health were analyzed for 95,837 Sydney respondents to the baseline survey of the 45 and Up Study between January 2006 and April 2010. We used conditional autoregressive models to create smoothed MVPA "disease maps" and assess relations between sufficient MVPA to improve health and area-level walkability adjusted for individual-level demographic, socioeconomic, and health factors, and area-level relative socioeconomic disadvantage. Within-cohort prevalence of meeting recommendations for sufficient walking, sufficient MVPA, and high MVPA were 31.7 (95% CI 31.4-32.0), 69.4 (95% CI 69.1-69.7), and 56.1 (95% CI 55.8-56.4) percent. Prevalence of sufficient walking was increased by 1.20 (95% CrI 1.12-1.29) and 1.07 (95% CrI 1.01-1.13) for high and medium-high versus low walkability postal areas, and for sufficient MVPA by 1.05 (95% CrI 1.01-1.08) for high versus low walkability postal areas. Walkability was not related to high MVPA. Postal area walkability explained 65.8 and 47.4 percent of residual geographic variation in sufficient walking and sufficient MVPA not attributable to individual-level factors. Walkability is associated with area-level prevalence and geographic variation in sufficient walking and sufficient MVPA to improve health in Sydney, Australia. Our study supports the use of walkability indexes at multiple spatial scales for informing population-level action to increase physical activity and the utility of spatial analysis for walkability research and planning.
A study of cognitive function in treatment-refractory obsessive-compulsive disorder treated with capsulotomy.

PubMed

Gong, Feilong; Li, Peng; Li, Bin; Zhang, Shizhen; Zhang, Xinjie; Yang, Sen; Liu, Hongbin; Wang, Wei

2018-02-01

OBJECTIVE Anterior capsulotomy (AC) is sometimes used as a last resort for treatment-refractory obsessive-compulsive disorder (OCD). Previous studies assessing neuropsychological outcomes in patients with OCD have identified several forms of cognitive dysfunction that are associated with the disease, but few have focused on changes in cognitive function in OCD patients who have undergone surgery. In the present study, the authors investigated the effects of AC on the cognitive function of patients with treatment-refractory OCD. METHODS The authors selected 14 patients with treatment-refractory OCD who had undergone bilateral AC between 2007 and 2013, 14 nonsurgically treated OCD patients, and 14 healthy control subjects for this study. The 3 groups were matched for sex, age, and education. Several neuropsychological tests, including Similarities and Block Design, which are subsets of the Wechsler Abbreviated Scale of Intelligence; Immediate and Delayed Logical Memory and Immediate and Delayed Visual Reproduction, which are subsets of the Wechsler Memory Scale-Revised; and Corrects, Categories, Perseverative Errors, Nonperseverative Errors, and Errors, subtests of the Wisconsin Card Sorting Test, were conducted in all 42 subjects at baseline and after AC, after nonsurgical treatment, or at 6-month intervals, as appropriate. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used to measure OCD symptoms in all 28 OCD patients. RESULTS The Y-BOCS scores decreased significantly in both OCD groups during the 12-month follow-up period. Surgical patients showed higher levels of improvement in verbal memory, visual memory, visuospatial skills, and executive function than the nonsurgically treated OCD patients. CONCLUSIONS The findings of this study suggest that AC not only reduces OCD symptoms but also attenuates moderate cognitive deficits.
Efficacy of Early Rehabilitation After Surgical Repair of Acute Aneurysmal Subarachnoid Hemorrhage: Outcomes After Verticalization on Days 2-5 Versus Day 12 Post-Bleeding.

PubMed

Milovanovic, Andjela; Grujicic, Danica; Bogosavljevic, Vojislav; Jokovic, Milos; Mujovic, Natasa; Markovic, Ivana Petronic

2017-01-01

To develop a specific rehabilitation protocol for patients who have undergone surgical repair of acute aneurysmal subarachnoid hemorrhage (aSAH), and to determine the time at which verticalization should be initiated after aSAH. Sixty-five patients who underwent acute-term surgery for aSAH and early rehabilitation were evaluated in groups: Group 1 (n=34) started verticalization on days 2-5 post-bleeding whereas Group 2 (n=31) started verticalization approximately day 12 post-bleeding. All patients were monitored for early complications, vasospasm and ischemia. Assessments of motor status, depression and anxiety (using Zung scales), and cognitive status (using the Mini-Mental State Examination (MMSE)) were conducted at discharge and at 1 and 3 months post-surgery. At discharge, Group 1 had a significantly higher proportion of patients with ischemia than Group 2 (p=0.004). Group 1 had a higher proportion of patients with hemiparesis than Group 2 three months post-surgery (p=0.015). Group 1 patients scored significantly higher on the Zung depression scale than Group 2 patients at 1 month (p=0.005) and 3 months post-surgery (p=0.001; the same applies to the Zung anxiety scale (p=0.006 and p=0.000, respectively). Group 2 patients scored significantly higher on the MMSE than those in Group 1 at discharge (p=0.040) and 1 month post-surgery (p=0.025). Early verticalization had no effect with respect to preventing early postoperative complications in this patient group. Once a patient has undergone acute surgical repair of aSAH, it is safe and preferred that rehabilitation be initiated immediately postsurgery. However, verticalization should not start prior to day 12 post-bleeding.
Correlation of Lactate Concentration in Peripheral Plasma and Cerebrospinal Fluid with Glasgow Outcome Scale for Patients with Tuberculous Meningitis Complicated by Acute Hydrocephalus Treated with Fluid Diversions.

PubMed

Faried, Ahmad; Arief, Gusman; Arifin, Muhammad Z; Nataprawira, Heda M

2018-03-01

Tuberculous meningitis (TBM) is an endemic infectious disease in developing countries, and it can become a serious illness in children. Treatment of TBM is more difficult and prone to failure than treatment of pulmonary tuberculosis. TBM causes hydrocephalus, cerebral edema, increased intracranial pressure, global ischemia, and neurologic deficits, which disturb cellular metabolism and increase lactate levels. A reliable, widely available clinical indicator of TBM severity is needed. Successful treatment of TBM is assessed using the Glasgow Outcome Scale (GOS). This prospective cohort study included 34 patients with TBM and acute hydrocephalus who had undergone fluid diversions and were admitted to Dr. Hasan Sadikin Hospital in Bandung from 2014 to 2015. A portable machine for blood glucose measurement was used to measure lactate concentrations. Statistical significance was defined as P ≤ 0.05. Average levels of plasma and cerebrospinal fluid (CSF) lactate were 1.99 ± 0.70 mmol/L and 3.04 ± 1.05 mmol/L, respectively. A significantly higher level of lactate was observed in CSF compared with plasma. Preoperative plasma lactate was negatively correlated to GOS (r = -0.539; P = 0.013), and CSF lactate was negatively correlated to GOS (r = -0.412; P = 0.027). Average lactate levels in CSF (central) were higher than plasma (peripheral) levels. GOS scale of patients decreased with increased plasma and CSF lactate levels. Examination of plasma and CSF lactate levels should be included in routine examinations to determine extent of cellular damage and GOS score in patients with TBM and acute hydrocephalus who have undergone fluid diversions. Copyright © 2017 Elsevier Inc. All rights reserved.
Ethanol content in different gasohol blend spills influences the decision-making on remediation technologies.

PubMed

Vilela Steiner, Leonardo; Toledo Ramos, Débora; Rubini Liedke, Ana Maria; Serbent, Maria Pilar; Corseuil, Henry Xavier

2018-04-15

Gasohol blend spills with variable ethanol content exert different electron acceptor demands in groundwater and the distinct dynamics undergone by these blends underscores the need for field-based information to aid decision-making on suitable remediation technologies for each gasohol blend spill. In this study, a comparison of two gasohol releases (E10 (10:90 ethanol and gasoline, v/v) and E25 (25:75 ethanol and gasoline, v/v) under monitored natural attenuation (MNA) and nitrate biostimulation, respectively) was conducted to assess the most effective remediation strategy for each gasohol release. Microbial communities were assessed to support geochemical data as well as to enable the characterization of important population shifts that evolve during biodegradation processes in E25 and E10 field experiments. Results revealed that natural attenuation processes sufficiently supported ethanol and BTEX compounds biodegradation in E10 release, due to the lower biochemical oxygen demand they exert relative to E25 blend. In E25 release, nitrate reduction was largely responsible for BTEX and ethanol biodegradation, as intended. First-order decay constants demonstrated that ethanol degradation rates were similar (p < 0.05) for both remediation technologies (2.05 ± 0.15 and 2.22 ± 0.23, for E25 and E10, respectively) whilst BTEX compounds exhibited different degradation rates (p > 0.05) that were higher for the experiment under MNA (0.33 ± 0.06 and 0.43 ± 0.03, for E25 and E10, respectively). Therefore, ethanol content in different gasohol blends can influence the decision-making on the most suitable remediation technology, as MNA processes can be applied for the remediation of gasohol blends with lower ethanol content (i.e., 10% v/v), once the aquifer geochemical conditions provide a sufficient electron acceptor pool. To the best of our knowledge, this is the first field study to monitor two long-term gasohol releases over various time scales in order to assess feasible remediation technologies for each scenario. Copyright © 2018 Elsevier Ltd. All rights reserved.
Multiscale Laboratory Infrastructure and Services to users: Plans within EPOS

NASA Astrophysics Data System (ADS)

Spiers, Chris; Willingshofer, Ernst; Drury, Martyn; Funiciello, Francesca; Rosenau, Matthias; Scarlato, Piergiorgio; Sagnotti, Leonardo; EPOS WG6, Corrado Cimarelli

2015-04-01

The participant countries in EPOS embody a wide range of world-class laboratory infrastructures ranging from high temperature and pressure experimental facilities, to electron microscopy, micro-beam analysis, analogue modeling and paleomagnetic laboratories. Most data produced by the various laboratory centres and networks are presently available only in limited "final form" in publications. Many data remain inaccessible and/or poorly preserved. However, the data produced at the participating laboratories are crucial to serving society's need for geo-resources exploration and for protection against geo-hazards. Indeed, to model resource formation and system behaviour during exploitation, we need an understanding from the molecular to the continental scale, based on experimental data. This contribution will describe the plans that the laboratories community in Europe is making, in the context of EPOS. The main objectives are: • To collect and harmonize available and emerging laboratory data on the properties and processes controlling rock system behaviour at multiple scales, in order to generate products accessible and interoperable through services for supporting research activities. • To co-ordinate the development, integration and trans-national usage of the major solid Earth Science laboratory centres and specialist networks. The length scales encompassed by the infrastructures included range from the nano- and micrometer levels (electron microscopy and micro-beam analysis) to the scale of experiments on centimetre sized samples, and to analogue model experiments simulating the reservoir scale, the basin scale and the plate scale. • To provide products and services supporting research into Geo-resources and Geo-storage, Geo-hazards and Earth System Evolution. If the EPOS Implementation Phase proposal presently under construction is successful, then a range of services and transnational activities will be put in place to realize these objectives.
Degradation Signatures of Open Ocean Microplastic Debris

NASA Astrophysics Data System (ADS)

Lavender Law, K. L.; Donohue, J. L.; Collins, T.; Proskurowsi, G.; Andrady, A. L.

2016-02-01

Microplastics collected from the open ocean offer few clues about their origin and history. There is currently no method to determine how long ocean plastic has undergone environmental weathering, how quickly fragmentation has occurred, or how small microplastic particles will ultimately become before (or if) they are fully degraded by microbial action. In the current absence of results from laboratory and field experiments designed to address these questions, we meticulously examined physical and chemical characteristics of open ocean microplastic particles collected over a 16-year period for clues about their weathering history. More than 1000 microplastic particles collected in the western North Atlantic between 1991 and 2007 were analyzed to determine polymer type, material density, mass and particle size, and were used to create a detailed catalogue of common microscopic surface features likely related to environmental exposure and weathering. Polyethylene and polypropylene, the two buoyant resins most commonly collected at the sea surface, can typically be distinguished by visual microscopy alone, and their particular characteristics lead us to hypothesize that these two resins weaken and fragment in different ways and on different time scales. A subset of resin pellets collected at sea were also analyzed using FTIR-ATR and/or FTIR microscopy for signatures of chemical degradation (e.g., carbonyl index) that are related to physical weathering characteristics such as color, quantified by the yellowness index.
Thermal explosion analysis of methyl ethyl ketone peroxide by non-isothermal and isothermal calorimetric applications.

PubMed

Chi, Jen-Hao; Wu, Sheng-Hung; Shu, Chi-Min

2009-11-15

In the past, process incidents attributed to organic peroxides (OPs) that involved near misses, over-pressures, runaway reactions, and thermal explosions occurred because of poor training, human error, incorrect kinetic assumptions, insufficient change management, and inadequate chemical knowledge in the manufacturing process. Calorimetric applications were employed broadly to test organic peroxides on a small-scale because of their thermal hazards, such as exothermic behavior and self-accelerating decomposition in the laboratory. In essence, methyl ethyl ketone peroxide (MEKPO) is highly reactive and exothermically unstable. In recent years, it has undergone many thermal explosions and runaway reaction incidents in the manufacturing process. Differential scanning calorimetry (DSC), vent sizing package 2 (VSP2), and thermal activity monitor (TAM) were employed to analyze thermokinetic parameters and safety index. The intent of the analyses was to facilitate the use of various auto-alarm equipments to detect over-pressure, over-temperature, and hazardous materials leaks for a wide spectrum of operations. Results indicated that MEKPO decomposition is detected at low temperatures (30-40 degrees C), and the rate of decomposition was shown to exponentially increase with temperature and pressure. Determining time to maximum rate (TMR), self-accelerating decomposition temperature (SADT), maximum temperature (T(max)), exothermic onset temperature (T(0)), and heat of decomposition (DeltaH(d)) was essential for identifying early-stage runaway reactions effectively for industries.
Removal of hydrogen sulfide and sulfur dioxide by carbons impregnated with triethylenediamine.

PubMed

Wu, Li-Chun; Chang, Tsu-Hua; Chung, Ying-Chien

2007-12-01

Activated carbon (AC) adsorption has long been considered to be a readily available technology for providing protection against exposure to acutely toxic gases. However, ACs without chemical impregnation have proven to be much less efficient than impregnated ACs in terms of gas removal. The impregnated ACs in current use are usually modified with metalloid impregnation agents (ASC-carbons; copper, chromium, or silver) to simultaneously enhance the chemical and physical properties of the ACs in removing specific poisonous gases. These metalloid agents, however, can cause acute poisoning to both humans and the environment, thereby necessitating the search for organic impregnation agents that present a much lower risk. The aim of the study reported here was to assess AC or ASC-carbon impregnated with triethylenediamine (TEDA) in terms of its adsorption capability for simulated hydrogen sulfide (H2S) and sulfur dioxide (SO2) gases. The investigation was undergone in a properly designed laboratory-scale and industrial fume hood evaluation. Using the system reported here, we obtained a significant adsorption: the removal capability for H2S and SO2 was 375 and 229 mg/g-C, respectively. BET measurements, element analysis, scanning electron microscopy, and energy dispersive spectrometry identified the removal mechanism for TEDA-impregnated AC to be both chemical and physical adsorption. Chemical adsorption and oxidation were the primary means by which TEDA-impregnated ASC-carbons removed the simulated gases.
Beyond-laboratory-scale prediction for channeling flows through subsurface rock fractures with heterogeneous aperture distributions revealed by laboratory evaluation

NASA Astrophysics Data System (ADS)

Ishibashi, Takuya; Watanabe, Noriaki; Hirano, Nobuo; Okamoto, Atsushi; Tsuchiya, Noriyoshi

2015-01-01

The present study evaluates aperture distributions and fluid flow characteristics for variously sized laboratory-scale granite fractures under confining stress. As a significant result of the laboratory investigation, the contact area in fracture plane was found to be virtually independent of scale. By combining this characteristic with the self-affine fractal nature of fracture surfaces, a novel method for predicting fracture aperture distributions beyond laboratory scale is developed. Validity of this method is revealed through reproduction of the results of laboratory investigation and the maximum aperture-fracture length relations, which are reported in the literature, for natural fractures. The present study finally predicts conceivable scale dependencies of fluid flows through joints (fractures without shear displacement) and faults (fractures with shear displacement). Both joint and fault aperture distributions are characterized by a scale-independent contact area, a scale-dependent geometric mean, and a scale-independent geometric standard deviation of aperture. The contact areas for joints and faults are approximately 60% and 40%. Changes in the geometric means of joint and fault apertures (µm), em, joint and em, fault, with fracture length (m), l, are approximated by em, joint = 1 × 102 l0.1 and em, fault = 1 × 103 l0.7, whereas the geometric standard deviations of both joint and fault apertures are approximately 3. Fluid flows through both joints and faults are characterized by formations of preferential flow paths (i.e., channeling flows) with scale-independent flow areas of approximately 10%, whereas the joint and fault permeabilities (m2), kjoint and kfault, are scale dependent and are approximated as kjoint = 1 × 10-12 l0.2 and kfault = 1 × 10-8 l1.1.
EPOS-WP16: A coherent and collaborative network of Solid Earth Multi-scale laboratories

NASA Astrophysics Data System (ADS)

Calignano, Elisa; Rosenau, Matthias; Lange, Otto; Spiers, Chris; Willingshofer, Ernst; Drury, Martyn; van Kan-Parker, Mirjam; Elger, Kirsten; Ulbricht, Damian; Funiciello, Francesca; Trippanera, Daniele; Sagnotti, Leonardo; Scarlato, Piergiorgio; Tesei, Telemaco; Winkler, Aldo

2017-04-01

Laboratory facilities are an integral part of Earth Science research. The diversity of methods employed in such infrastructures reflects the multi-scale nature of the Earth system and is essential for the understanding of its evolution, for the assessment of geo-hazards and for the sustainable exploitation of geo-resources. In the frame of EPOS (European Plate Observing System), the Working Package 16 represents a developing community of European Geoscience Multi-scale laboratories. The participant and collaborating institutions (Utrecht University, GFZ, RomaTre University, INGV, NERC, CSIC-ICTJA, CNRS, LMU, C4G-UBI, ETH, CNR*) embody several types of laboratory infrastructures, engaged in different fields of interest of Earth Science: from high temperature and pressure experimental facilities, to electron microscopy, micro-beam analysis, analogue tectonic and geodynamic modelling and paleomagnetic laboratories. The length scales encompassed by these infrastructures range from the nano- and micrometre levels (electron microscopy and micro-beam analysis) to the scale of experiments on centimetres-sized samples, and to analogue model experiments simulating the reservoir scale, the basin scale and the plate scale. The aim of WP16 is to provide two services by the year 2019: first, providing virtual access to data from laboratories (data service) and, second, providing physical access to laboratories (transnational access, TNA). Regarding the development of a data service, the current status is such that most data produced by the various laboratory centres and networks are available only in limited "final form" in publications, many data remain inaccessible and/or poorly preserved. Within EPOS the TCS Multi-scale laboratories is collecting and harmonizing available and emerging laboratory data on the properties and process controlling rock system behaviour at all relevant scales, in order to generate products accessible and interoperable through services for supporting research activities into Geo-resources and Geo-storage, Geo-hazards and Earth System Evolution. Regarding the provision of physical access to laboratories the current situation is such that access to WP16's laboratories is often based on professional relations, available budgets, shared interests and other constraints. In WP16 we aim at reducing the present diversity and non-transparency of access rules and replace ad-hoc procedures for access by a streamlined mechanisms, objective rules and a transparent policy. We work on procedures and mechanisms regulating application, negotiation, evaluation, feedback, selection, admission, approval, feasibility check, setting-up, use, monitoring and dismantling. In the end laboratories should each have a single point providing clear and transparent information on the facility itself, its services, access policy, data management policy and the legal terms and conditions for use of equipment. Through its role as an intermediary and information broker, EPOS will acquire a wealth of information from Research Infrastructures and users on the establishment of efficient collaboration agreements.
Decision dynamics of departure times: Experiments and modeling

NASA Astrophysics Data System (ADS)

Sun, Xiaoyan; Han, Xiao; Bao, Jian-Zhang; Jiang, Rui; Jia, Bin; Yan, Xiaoyong; Zhang, Boyu; Wang, Wen-Xu; Gao, Zi-You

2017-10-01

A fundamental problem in traffic science is to understand user-choice behaviors that account for the emergence of complex traffic phenomena. Despite much effort devoted to theoretically exploring departure time choice behaviors, relatively large-scale and systematic experimental tests of theoretical predictions are still lacking. In this paper, we aim to offer a more comprehensive understanding of departure time choice behaviors in terms of a series of laboratory experiments under different traffic conditions and feedback information provided to commuters. In the experiment, the number of recruited players is much larger than the number of choices to better mimic the real scenario, in which a large number of commuters will depart simultaneously in a relatively small time window. Sufficient numbers of rounds are conducted to ensure the convergence of collective behavior. Experimental results demonstrate that collective behavior is close to the user equilibrium, regardless of different scales and traffic conditions. Moreover, the amount of feedback information has a negligible influence on collective behavior but has a relatively stronger effect on individual choice behaviors. Reinforcement learning and Fermi learning models are built to reproduce the experimental results and uncover the underlying mechanism. Simulation results are in good agreement with the experimentally observed collective behaviors.

Immune monitoring of clinical trials with biotherapies.

PubMed

Whiteside, Theresa L

2008-01-01

Immune monitoring of biotherapy clinical trials has undergone a considerable change in recent years. Technical advances together with new insights into molecular immunology have ushered a new genre of assays into immune monitoring. Single-cell assays, multiplex profiling, and signaling molecule detection have replaced formerly used bulk assays, such as proliferation or cytotoxicity. The emphasis on immune cell functions and quantitation of antigen-specific T cells has been playing a major role in attempts to establish correlations between therapy-induced alterations in immune responses and clinical endpoints. However, this has been an elusive goal to achieve, and there is a special need for improving the quality of serial monitoring to ensure that it adequately and reliably measures changes induced by administered biotherapy. In this respect, monitoring performed in specialized reference laboratories operating as good laboratory practice (GLP) facilities and strengthening of interactions between the clinical investigator, the clinical immunologist, and the biostatistician are crucial for successful use of immune monitoring in clinical studies.
Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis.

PubMed

Kerr, P J; Perkins, H D; Inglis, B; Stagg, R; McLaughlin, E; Collins, S V; Van Leeuwen, B H

2004-06-20

Rabbit IL-4 was expressed in the virulent standard laboratory strain (SLS) and the attenuated Uriarra (Ur) strain of myxoma virus with the aim of creating a Th2 cytokine environment and inhibiting the development of an antiviral cell-mediated response to myxomatosis in infected rabbits. This allowed testing of a model for genetic resistance to myxomatosis in wild rabbits that have undergone 50 years of natural selection for resistance to myxomatosis. Expression of IL-4 significantly enhanced virulence of both virulent and attenuated virus strains in susceptible (laboratory) and resistant (wild) rabbits. SLS-IL-4 completely overcame genetic resistance in wild rabbits. The pathogenesis of SLS-IL-4 was compared in susceptible and resistant rabbits. The results support a model for resistance to myxomatosis of an enhanced innate immune response controlling virus replication and allowing an effective antiviral cell-mediated immune response to develop in resistant rabbits. Expression of IL-4 did not overcome immunity to myxomatosis induced by immunization.
[Value of history and clinical and laboratory data for the diagnosis of dehydration due to acute diarrhea in children younger than 5 years].

PubMed

Pruvost, Isabelle; Dubos, François; Aurel, Marie; Hue, Valérie; Martinot, Alain

2008-04-01

Acute diarrhea is frequent, costly because of the number of hospital admissions required, and sometimes serious, even fatal to children in France. The clinical diagnosis of dehydration is difficult, but essential to determine management. To summarize the published data on the value of clinical history, clinical signs and laboratory results for diagnosing dehydration during acute diarrhea in young (1 month-5 years) non-malnourished children. Four databases (Medline, INIST, Ovid, and Cochrane) were searched through November 2006, with the key words "dehydration" subcategories "diagnosis, or etiology, or history", "diarrhea" subcategory "diagnosis", and age limits "infant or preschool child". We selected the articles and reviews that included as an endpoint for dehydration "weight gain > 5% after recovery" (the gold standard). Thirteen studies were selected. No single clinical history item, clinical sign or laboratory value was sufficient to discriminate between children with and without dehydration. The reproducibility of clinical signs varied substantially between studies. Persistent skin folds and signs of vasoconstriction contributed the most information, with good specificity but sensitivity < 50%. The combination of at least 3 clinical signs was most discriminative for dehydration. No dehydration scale has been validated. None of the studies selected had a very high level of proof (level 1 and 2); neither signs nor scores have been validated internally or externally because of the low number of subjects. The diagnosis of dehydration due to acute diarrhea in young children depends on the number of signs present, since no individual element of clinical history, clinical picture or laboratory tests distinguished dehydration. Other studies are necessary.
Mercury measurements in the ocean - GEOTRACES intercalibration exercises

NASA Astrophysics Data System (ADS)

Heimbürger, L. E.

2015-12-01

Mercury is amongst the least concentrated trace metals in the ocean. We need to be able to measure, understand and interpret variability in mercury concentrations in seawater, which is often as low as some 10 percent. We organized international intcalibration exercises for total mercury and total methylmercury determination in seawater collected during the 2013 Dutch GEOTRACES MedBlack cruise (GA04- Black Sea), the 2014 French GEOTRACES GEOVIDE (GA01- North Atlantic Ocean) and the 2015 German GEOTRACES TranArc II cruise ( GN04 - Arctic Ocean). The exercises were intended to primarily evaluate the analytical performance of each participating laboratory. Therefore each laboratory received a single sample bottle of similar size, that has undergone the same cleaning procedure prior to sampling, and each sample was preserved in the same manner. The 2013 exercise was intended as a broader screening with a maximum number (25) of participating laboratories. Results indicated substantial disagreement between the participating laboratories, for both total mercury and methylmercury determinations. For the 2014 exercise we could only invite 10 laboratories of the 2013 exercise. Intercomparability of the second exercise was considerably better, but needs to be further improved in the years to come. The 2015 will be organized this summer. We will present the results of both intercalibration exercises in detail, attempt to explain causes for disagreements, and share our ideas about future developments to achieve traceable mercury measurements in the oceans. We will also make use of this occasion to plan the 2016 GEOTRACES intercalibration cruise.
Inflammation Thread Runs across Medical Laboratory Specialities.

PubMed

Nydegger, Urs; Lung, Thomas; Risch, Lorenz; Risch, Martin; Medina Escobar, Pedro; Bodmer, Thomas

2016-01-01

We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associated with diseases with genetic glitch of complement components are unfolding. The C4 component serum levels depend on sufficient vitamin D whilst low vitamin D is inversely related to IgG1, IgA, and C3 linking vitamin sufficiency to innate immunity. Whole genome sequencing of microbial organisms may distinguish virulent from nonvirulent and antibiotic resistant from nonresistant varieties of the same species and thus can be listed in personal big data banks including microbiological pathology; the big data warehouse continues to grow.
Inflammation Thread Runs across Medical Laboratory Specialities

PubMed Central

Lung, Thomas; Risch, Lorenz; Risch, Martin; Medina Escobar, Pedro; Bodmer, Thomas

2016-01-01

We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associated with diseases with genetic glitch of complement components are unfolding. The C4 component serum levels depend on sufficient vitamin D whilst low vitamin D is inversely related to IgG1, IgA, and C3 linking vitamin sufficiency to innate immunity. Whole genome sequencing of microbial organisms may distinguish virulent from nonvirulent and antibiotic resistant from nonresistant varieties of the same species and thus can be listed in personal big data banks including microbiological pathology; the big data warehouse continues to grow. PMID:27493451
Building a Laboratory-Scale Biogas Plant and Verifying its Functionality

NASA Astrophysics Data System (ADS)

Boleman, Tomáš; Fiala, Jozef; Blinová, Lenka; Gerulová, Kristína

2011-01-01

The paper deals with the process of building a laboratory-scale biogas plant and verifying its functionality. The laboratory-scale prototype was constructed in the Department of Safety and Environmental Engineering at the Faculty of Materials Science and Technology in Trnava, of the Slovak University of Technology. The Department has already built a solar laboratory to promote and utilise solar energy, and designed SETUR hydro engine. The laboratory is the next step in the Department's activities in the field of renewable energy sources and biomass. The Department is also involved in the European Union project, where the goal is to upgrade all existed renewable energy sources used in the Department.
Effector Gene Suites in Some Soil Isolates of Fusarium oxysporum Are Not Sufficient Predictors of Vascular Wilt in Tomato.

PubMed

Jelinski, Nicolas A; Broz, Karen; Jonkers, Wilfried; Ma, Li-Jun; Kistler, H Corby

2017-07-01

Seventy-four Fusarium oxysporum soil isolates were assayed for known effector genes present in an F. oxysporum f. sp. lycopersici race 3 tomato wilt strain (FOL MN-25) obtained from the same fields in Manatee County, Florida. Based on the presence or absence of these genes, four haplotypes were defined, two of which represented 96% of the surveyed isolates. These two most common effector haplotypes contained either all or none of the assayed race 3 effector genes. We hypothesized that soil isolates with all surveyed effector genes, similar to FOL MN-25, would be pathogenic toward tomato, whereas isolates lacking all effectors would be nonpathogenic. However, inoculation experiments revealed that presence of the effector genes alone was not sufficient to ensure pathogenicity on tomato. Interestingly, a nonpathogenic isolate containing the full suite of unmutated effector genes (FOS 4-4) appears to have undergone a chromosomal rearrangement yet remains vegetatively compatible with FOL MN-25. These observations confirm the highly dynamic nature of the F. oxysporum genome and support the conclusion that pathogenesis among free-living populations of F. oxysporum is a complex process. Therefore, the presence of effector genes alone may not be an accurate predictor of pathogenicity among soil isolates of F. oxysporum.
Observations of Magnetic Evolution and Network Flares Driven by Photospheric Flows in the Quiet Sun

NASA Astrophysics Data System (ADS)

Attie, Raphael; Thompson, Barbara J.

2017-08-01

The quiet Sun may be the biggest laboratory to study physical elementary processes of fundamental importance to space plasma. The advantage is the continuous availability of small-scale events, carrying the hidden microphysics that is responsible for larger-scale phenomena. By small-scale events, we mean spatial dimensions of a few Mm at most, and durations of less than an hour. I present here an attempt to describe and understand the coupling between the photospheric flows, the photospheric magnetic flux, and small-scale energetic transient events. By adapting and improving the highly efficient Balltracking technique for Hinode/SOT data, we relate the fine structures of the supergranular flow fields with the magnetic flux evolution. For studying the dynamics of the latter, and more precisely, the magnetic flux cancellation at sites of energy releases, we applied a new feature tracking algorithm called "Magnetic Balltracking" -- which tracks photospheric magnetic elements -- to high-resolution magnetograms from Hinode/SOT.Using observations of the low corona in soft X-rays with Hinode/XRT, we analyse the triggering mechanism of small-scale network flares. By tracking both the flow fields on the one hand, and the magnetic motions on the other hand, we relate the flows with cancelling magnetic flux. We identify two patterns of horizontal flows that act as catalysts for efficient magnetic reconnection: (i) Funnel-shaped streamlines in which the magnetic flux is carried, and (ii) large-scale vortices (~10 Mm and above) at the network intersections, in which distant magnetic features of opposite polarities seem to be sucked in and ultimately vanish. The excess energy stored in the stressed magnetic field of the vortices is sufficient to power network flares.Prospects for determining the magnetic energy budget in the quiet sun are discussed.
Pelvic floor muscle training for bowel dysfunction following colorectal cancer surgery: A systematic review.

PubMed

Lin, Kuan-Yin; Granger, Catherine L; Denehy, Linda; Frawley, Helena C

2015-11-01

To identify, evaluate and synthesize the evidence examining the effectiveness of pelvic floor muscle training (PFMT) on bowel dysfunction in patients who have undergone colorectal cancer surgery. Eight electronic databases (MEDLINE 1950-2014; CINAHL 1982-2014; EMBASE 1980-2014; Scopus 1823-2014; PsycINFO 1806-2014; Web of Science 1970-2014; Cochrane Library 2014; PEDro 1999-2014) were systematically searched in March 2014. Reference lists of identified articles were cross referenced and hand searched. Randomized controlled trials, cohort studies and case series were included if they investigated the effects of conservative treatments, including PFMT on bowel function in patients with colorectal cancer following surgery. Two reviewers independently assessed the risk of bias of studies using the Newcastle-Ottawa Scale (NOS). Six prospective non-randomized studies and two retrospective studies were included. The mean (SD) NOS risk of bias score was 4.9 (1.2) out of 9; studies were limited by a lack of non-exposed cohort, lack of independent blinded assessment, heterogeneous treatment protocols, and lack of long-term follow-up. The majority of studies reported significant improvements in stool frequency, incontinence episodes, severity of fecal incontinence, and health-related quality of life (HRQoL) after PFMT. Meta-analysis was not possible due to lack of randomized controlled trials. Pelvic floor muscle training for patients following surgery for colorectal cancer appears to be associated with improvements in bowel function and HRQoL. Results from non-randomized studies are promising but randomized controlled trials with sufficient power are needed to confirm the effectiveness of PFMT in this population. © 2014 Wiley Periodicals, Inc.
Clinical Features and Surgical Treatment of Superficial Peroneal Nerve Entrapment Neuropathy.

PubMed

Matsumoto, Juntaro; Isu, Toyohiko; Kim, Kyongsong; Iwamoto, Naotaka; Yamazaki, Kazuyoshi; Isobe, Masanori

2018-06-20

Superficial peroneal nerve (S-PN) entrapment neuropathy (S-PNEN) is comparatively rare and may be an elusive clinical entity. There is yet no established surgical procedure to treat idiopathic S-PNEN. We report our surgical treatment and clinical outcomes. We surgically treated 5 patients (6 sites) with S-PNEN. The 2 men and 3 women ranged in age from 67 to 91 years; one patient presented with bilateral leg involvement. Mean post-operative follow-up was 25.3 months. We recorded their symptoms before- and at the latest follow-up visit after surgery using a Numerical Rating Scale and the Japan Orthopedic Association score to evaluate the affected area. We microsurgically decompressed the affected S-PN under local anesthesia without a proximal tourniquet. We made a linear skin incision along the S-PN and performed wide S-PN decompression from its insertion point at the peroneal tunnel to the peroneus longus muscle (PLM) to the point where the S-PN penetrated the deep fascia. One patient who had undergone decompression in the area of a Tinel-like sign at the initial surgery suffered symptom recurrence and required re-operation 4 months later. We performed additional extensive decompression to address several sites with a Tinel-like sign. All 5 operated patients reported symptom improvement. In patients with idiopathic S-PNEN, neurolysis under local anesthesia may be curative. Decompression involving only the Tinel area may not be sufficient and it may be necessary to include the area from the PLM to the peroneal nerve exit point along the S-PN.
Advanced, Energy-Efficient Hybrid Membrane System for Industrial Water Reuse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toy, Lora; Choi, Young Chul; Hendren, Zachary

In the U.S. manufacturing sector, current industrial water use practices are energy-intensive and utilize and discharge high volumes of waters, rendering them not sustainable especially in light of the growing scarcity of suitable water supplies. To help address this problem, the goal of this project was to develop an advanced, cost-effective, hybrid membrane-based water treatment system that can improve the energy efficiency of industrial wastewater treatment while allowing at least 50% water reuse efficiency. This hybrid process would combine emerging Forward Osmosis (FO) and Membrane Distillation (MD) technology components into an integrated FO-MD system that can beneficially utilize low-grade wastemore » heat (i.e., T < 450 °F) in industrial facilities to produce distilled-quality product water for reuse. In this project, laboratory-, bench-, and pilot-scale experiments on the hybrid FO-MD system were conducted for industrial wastewater treatment. It was demonstrated at laboratory, bench, and pilot scales that FO-MD membrane technology can concentrate brine to very high total dissolved solids (TDS) levels (>200,000 ppm) that are at least 2.5 times higher than the TDS level to which RO can achieve. In laboratory testing, currently available FO and MD membranes were tested to select for high-performing membranes with high salt rejection and high water flux. Multiple FO membrane/draw-salt solution combinations that gave high water flux with higher than 98% salt rejection were also identified. Reverse draw-salt fluxes were observed to be much lower for divalent salts than for monovalent salts. MD membranes were identified that had 99.9+% salt rejection and water flux as high as 50-90 L/(m 2·h) for flat-sheet membranes and >20 L/(m 2·h) for hollow fibers. In bench-scale testing, a single unit of commercially available FO and MD membrane modules were evaluated for continuous, integrated operation. Using the laboratory- and bench-scale test data, numerical modeling was performed on the FO and MD processes to estimate engineering parameters for a larger-scale pilot unit. Based on the experimental studies and modeling results, a pilot-scale, integrated FO-MD prototype unit was designed and built for trailer-mounted operation. This prototype system was fed real industrial wastewater, which could not be further treated by conventional technologies, from an oil production facility and was successfully operated for over 15 weeks without major stoppage. About 90% water recovery was possible, while concentrating the TDS from 12,000 ppm up to 190,500 ppm. The FO-MD prototype rejected most wastewater contaminants while producing water with <300 ppm TDS, even when the feed TDS was higher than 150,000 ppm. No chemical cleaning was necessary during the pilot testing period. Flushing the system with dechlorinated tap water was sufficient to reset the membranes for the next set of test conditions. Pilot performance and membrane autopsy showed that, even though the feed was concentrated more than 10 times, membrane fouling was unnoticeable and no defects were detected on the FO and MD membrane surfaces. This project demonstrated the technical feasibility of the hybrid FO-MD process by taking water already treated to the limit with the highest level of current technologies and further concentrating it 10-fold by using mostly low-cost materials. Because no membranes suitable for full-scale plant applications are available at present, economical feasibility of the hybrid technology is still uncertain, but it is expected that broader industry participation can further reduce FO-MD process costs.« less
Effect of early correction of nasal septal deformity in unilateral cleft lip and palate on inferior turbinate hypertrophy and nasal patency.

PubMed

Pinto, Valentina; Piccin, Ottavio; Burgio, Luca; Summo, Valeria; Antoniazzi, Elisa; Morselli, Paolo G

2018-05-01

A relatively neglected aspect of cleft lip nasal deformity is the effect of septal deviation and inferior turbinate hypertrophy (ITH) on the functional airway. In particular, ITH in the noncleft side can be especially problematic, because it reduces the healthy nasal area, creating bilateral nasal obstruction that might affect the growth of the maxillofacial skeleton. Although these anatomic and functional changes are documented, few recommendations have been developed regarding the proper approach to ITH. The aim of the present study was to asses the ITH severity and determine the degree of nasal airway patency in patients who have undergone primary correction of the nasal septum during lip repair compared to patients operated on without primary septal correction. The study population included two groups. One group consisted of twenty unilateral cleft lip palate UCLP patients who have previously undergone primary rhinoseptoplasty as part of their treatment plan. The control group consisted of twenty UCLP patients operated on without rhinoseptal correction. The Nasal Obstructive Symptom Evaluation (NOSE) scale and nasal endoscopy were used to assess nasal obstruction. The overall untreated group reported severe symptoms across all NOSE scale dimensions more frequently than children who have undergone primary rhinoseptoplasty. The difference was statistically significant for each dimensions (p < 0.05). The mean NOSE score for group A and group B was 21.4 ± 9.4 and 70.8 ± 17.2 respectively (p < 0.0001). In group A turbinate size decreased significantly (p < 0.05) compared to pre-operative data. Comparing the two groups a statistically significant difference in turbinate size was observed (p < 0.0001). The results of the present study confirm that there is a significant degree of ITH and nasal airway dysfunction in patients with UCLP. Early septal repositioning during primary cleft lip repair results in a statistically significant reduction in IT size and improvement of nasal patency. Copyright © 2018 Elsevier B.V. All rights reserved.
Practices for Identifying and Rejecting Hemolyzed Specimens Are Highly Variable in Clinical Laboratories.

PubMed

Howanitz, Peter J; Lehman, Christopher M; Jones, Bruce A; Meier, Frederick A; Horowitz, Gary L

2015-08-01

Hemolysis is an important clinical laboratory quality attribute that influences result reliability. To determine hemolysis identification and rejection practices occurring in clinical laboratories. We used the College of American Pathologists Survey program to distribute a Q-Probes-type questionnaire about hemolysis practices to Chemistry Survey participants. Of 3495 participants sent the questionnaire, 846 (24%) responded. In 71% of 772 laboratories, the hemolysis rate was less than 3.0%, whereas in 5%, it was 6.0% or greater. A visual scale, an instrument scale, and combination of visual and instrument scales were used to identify hemolysis in 48%, 11%, and 41% of laboratories, respectively. A picture of the hemolysis level was used as an aid to technologists' visual interpretation of hemolysis levels in 40% of laboratories. In 7.0% of laboratories, all hemolyzed specimens were rejected; in 4% of laboratories, no hemolyzed specimens were rejected; and in 88% of laboratories, some specimens were rejected depending on hemolysis levels. Participants used 69 different terms to describe hemolysis scales, with 21 terms used in more than 10 laboratories. Slight and moderate were the terms used most commonly. Of 16 different cutoffs used to reject hemolyzed specimens, moderate was the most common, occurring in 30% of laboratories. For whole blood electrolyte measurements performed in 86 laboratories, 57% did not evaluate the presence of hemolysis, but for those that did, the most common practice in 21 laboratories (24%) was centrifuging and visually determining the presence of hemolysis in all specimens. Hemolysis practices vary widely. Standard assessment and consistent reporting are the first steps in reducing interlaboratory variability among results.
A comparison of relative toxicity rankings by some small-scale laboratory tests

NASA Technical Reports Server (NTRS)

Hilado, C. J.; Cumming, H. J.

1977-01-01

Small-scale laboratory tests for fire toxicity, suitable for use in the average laboratory hood, are needed for screening and ranking materials on the basis of relative toxicity. The performance of wool, cotton, and aromatic polyamide under several test procedures is presented.
Results of posterior cervical foraminotomy for treatment of cervical spondylitic radiculopathy.

PubMed

Grieve, J P; Kitchen, N D; Moore, A J; Marsh, H T

2000-02-01

We evaluated the results of posterior cervical foraminotomy for spondylitic radiculopathy using a questionnaire sent to all 77 patients who had undergone surgery between 1990 and 1995 at our institution. Sixty-two patients (40 male) returned their questionnaires, one of whom had undergone two procedures (dealt with as separate events). Sixty patients complained of pre-operative arm pain; of these 42 (70%) had complete or > 75% resolution of their pain, 14 (23%) had < 75% improvement in their pain and four (7%) had the same or worsened pain at the time of the questionnaire. Sixteen patients (27%) reported initial improvement in symptoms with subsequent deterioration. The mean patient satisfaction score using a linear analogue scale from 0 to 10 was 7.5. Main postoperative complaints were neck pain (22%), persisting motor deficit (6%) and persisting sensory deficit (9%). One patient suffered nerve root damage at surgery. For unilateral and, in some cases, multi-level degenerative disease causing cervical radiculopathy, posterior cervical foraminotomy is a useful technique with the advantage of avoiding fusion, immobilization and the long-term risk of instability.
Achieving across-laboratory replicability in psychophysical scaling

PubMed Central

Ward, Lawrence M.; Baumann, Michael; Moffat, Graeme; Roberts, Larry E.; Mori, Shuji; Rutledge-Taylor, Matthew; West, Robert L.

2015-01-01

It is well known that, although psychophysical scaling produces good qualitative agreement between experiments, precise quantitative agreement between experimental results, such as that routinely achieved in physics or biology, is rarely or never attained. A particularly galling example of this is the fact that power function exponents for the same psychological continuum, measured in different laboratories but ostensibly using the same scaling method, magnitude estimation, can vary by a factor of three. Constrained scaling (CS), in which observers first learn a standardized meaning for a set of numerical responses relative to a standard sensory continuum and then make magnitude judgments of other sensations using the learned response scale, has produced excellent quantitative agreement between individual observers’ psychophysical functions. Theoretically it could do the same for across-laboratory comparisons, although this needs to be tested directly. We compared nine different experiments from four different laboratories as an example of the level of across experiment and across-laboratory agreement achievable using CS. In general, we found across experiment and across-laboratory agreement using CS to be significantly superior to that typically obtained with conventional magnitude estimation techniques, although some of its potential remains to be realized. PMID:26191019
Multiplex ligation-dependent probe amplification analysis on capillary electrophoresis instruments for a rapid gene copy number study.

PubMed

Jankowski, Stéphane; Currie-Fraser, Erica; Xu, Licen; Coffa, Jordy

2008-09-01

Annotated DNA samples that had been previously analyzed were tested using multiplex ligation-dependent probe amplification (MLPA) assays containing probes targeting BRCA1, BRCA2, and MMR (MLH1/MSH2 genes) and the 9p21 chromosomal region. MLPA polymerase chain reaction products were separated on a capillary electrophoresis platform, and the data were analyzed using GeneMapper v4.0 software (Applied Biosystems, Foster City, CA). After signal normalization, loci regions that had undergone deletions or duplications were identified using the GeneMapper Report Manager and verified using the DyeScale functionality. The results highlight an easy-to-use, optimal sample preparation and analysis workflow that can be used for both small- and large-scale studies.
[Mandatory reporting of antimicrobial-resistant pathogens. What should, what can be achieved? : assessment related to the particular facility seems crucial].

PubMed

Heudorf, Ursel; Gottschalk, R; Exner, M

2014-11-01

Antimicrobial-resistant organisms are regarded as a particular threat to the public health of the European population. In Germany the requirement for a national rollout reporting of positive laboratory test results for methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures was implemented in 2009. This was followed in 2011 by the introduction of a laboratory-based, rollout reporting system for the detection of gram-negative bacteria with acquired carbapenem-resistance (carbapenem-resistant organisms, CRO) in the federal state of Hessen. This article will present the experience gained in Frankfurt am Main with the existing reporting system. Blood or cerebrospinal fluid cultures positive for MRSA were reported from all Frankfurt clinics between 2010 and 2013. The objective of preventing nosocomial infections by introducing a mandatory reporting for MRSA in blood cultures was only partially achieved by the reporting procedure on a population scale. Instead, reporting on a clinic-based scale, i.e., incidence per 1,000 patient days should be used. Moreover, mandatory reporting of clusters of nosocomial colonizations with MRSA could be an appropriate measure for the timely prevention of nosocomial infections with these organisms. CROs were reported from nearly all clinics as well as the ambulatory setting. Different reporting criteria have resulted not only in a greatly varying workload for the institutions and the health authorities but also in vastly different numbers of reported events. Regarding the importance of CRO, mandatory reporting seems reasonable. Criteria of reporting should be simple and easily comprehensible, i.e., all 4MRGN (gram-negative bacteria with resistance against four antibiotic groups such as acylureidopenicillins, third- and fourth-generation cephalosporins, fluorchinolones, and carbapenems) according to the German Commission on Hospital Hygiene and Infection Prevention (KRINKO) should be considered. Reporting and evaluation of multidrug-resistant organisms (MDRO) in a population-based system does not seem to be sufficient regarding these organisms with high importance for hospital hygiene; mandatory reporting on an anonymous clinic-based scale should be used.
Laser propagation through full-scale, high-gain MagLIF gas pipes using the NIF

NASA Astrophysics Data System (ADS)

Pollock, Bradley; Sefkow, Adam; Goyon, Clement; Strozzi, David; Khan, Shahab; Rosen, Mordy; Campbell, Mike; Logan, Grant; Peterson, Kyle; Moody, John

2016-10-01

The first relevant measurements of laser propagation through surrogate high-gain MagLIF gas pipe targets at full scale have been performed at the NIF, using 30 kJ of laser drive from one quad in a 10 ns pulse at an intensity of 2e14 W/cm2. The unmagnetized pipe is filled with 1 atm of 99%/1% neopentane/Ar, and uses an entrance window of 0.75 um polyimide and an exit window of 0.3 um of Ta backed with 5 um of polyimide. Side-on x-ray emission from the plasma is imaged through the 100 um-thick epoxy wall onto a framing camera at four times during the drive, and is in excellent agreement with pre-shot HYDRA radiation-hydrodynamics modeling. X-ray emission from the Ta exit plane is imaged onto a streak camera to determine the timing and intensity of the laser burning through the pipe, and the Ar emission from the center of the pipe is spectrally- and temporally-resolved to determine the plasma electron temperature. Backscatter is measured throughout the laser drive, and is found to be of significance only when the laser reaches the Ta exit plane and produces SBS. These first results in unmagnetized surrogate gas fills are encouraging since they demonstrate sufficient laser energy absorption and low LPI losses within high-density long-scale-length plasmas for proposed high-gain MagLIF target designs. We will discuss plans to magnetize targets filled with high-density DT gas in future experiments. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the National Nuclear Security Administration under Contract No. DE-AC04-94AL85000.

HPC simulations of grain-scale spallation to improve thermal spallation drilling

NASA Astrophysics Data System (ADS)

Walsh, S. D.; Lomov, I.; Wideman, T. W.; Potter, J.

2012-12-01

Thermal spallation drilling and related hard-rock hole opening techniques are transformative technologies with the potential to dramatically reduce the costs associated with EGS well drilling and improve the productivity of new and existing wells. In contrast to conventional drilling methods that employ mechanical means to penetrate rock, thermal spallation methods fragment rock into small pieces ("spalls") without contact via the rapid transmission of heat to the rock surface. State-of-the-art constitutive models of thermal spallation employ Weibull statistical failure theory to represent the relationship between rock heterogeneity and its propensity to produce spalls when heat is applied to the rock surface. These models have been successfully used to predict such factors as penetration rate, spall-size distribution and borehole radius from drilling jet velocity and applied heat flux. A properly calibrated Weibull model would permit design optimization of thermal spallation drilling under geothermal field conditions. However, although useful for predicting system response in a given context, Weibull models are by their nature empirically derived. In the past, the parameters used in these models were carefully determined from laboratory tests, and thus model applicability was limited by experimental scope. This becomes problematic, for example, if simulating spall production at depths relevant for geothermal energy production, or modeling thermal spallation drilling in new rock types. Nevertheless, with sufficient computational resources, Weibull models could be validated in the absence of experimental data by explicit small-scale simulations that fully resolve rock grains. This presentation will discuss how high-fidelity simulations can be used to inform Weibull models of thermal spallation, and what these simulations reveal about the processes driving spallation at the grain-scale - in particular, the role that inter-grain boundaries and micro-pores play in the onset and extent of spallation. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.
Ecological assessment of nano-enabled supercapacitors for automotive applications

NASA Astrophysics Data System (ADS)

Weil, M.; Dura, H.; Shimon, B.; Baumann, M.; Zimmermann, B.; Ziemann, S.; Lei, C.; Markoulidis, F.; Lekakou, T.; Decker, M.

2012-09-01

New materials on nano scale have the potential to overcome existing technical barriers and are one of the most promising key technologies to enable the decoupling of economic growth and resource consumption. Developing these innovative materials for industrial applications means facing a complex quality profile, which includes among others technical, economic, and ecological aspects. So far the two latter aspects are not sufficiently included in technology development, especially from a life cycle point of view. Supercapacitors are considered a promising option for electric energy storage in hybrid and full electric cars. In comparison with presently used lithium based electro chemical storage systems supercapacitors possess a high specific power, but a relatively low specific energy. Therefore, the goal of ongoing research is to develop a new generation of supercapacitors with high specific power and high specific energy. To reach this goal particularly nano materials are developed and tested on cell level. In the presented study the ecological implications (regarding known environmental effects) of carbon based nano materials are analysed using Life Cycle Assessment (LCA). Major attention is paid to efficiency gains of nano particle production due to scaling up of such processes from laboratory to industrial production scales. Furthermore, a developed approach will be displayed, how to assess the environmental impact of nano materials on an automotive system level over the whole life cycle.
Multiscale permutation entropy analysis of laser beam wandering in isotropic turbulence.

PubMed

Olivares, Felipe; Zunino, Luciano; Gulich, Damián; Pérez, Darío G; Rosso, Osvaldo A

2017-10-01

We have experimentally quantified the temporal structural diversity from the coordinate fluctuations of a laser beam propagating through isotropic optical turbulence. The main focus here is on the characterization of the long-range correlations in the wandering of a thin Gaussian laser beam over a screen after propagating through a turbulent medium. To fulfill this goal, a laboratory-controlled experiment was conducted in which coordinate fluctuations of the laser beam were recorded at a sufficiently high sampling rate for a wide range of turbulent conditions. Horizontal and vertical displacements of the laser beam centroid were subsequently analyzed by implementing the symbolic technique based on ordinal patterns to estimate the well-known permutation entropy. We show that the permutation entropy estimations at multiple time scales evidence an interplay between different dynamical behaviors. More specifically, a crossover between two different scaling regimes is observed. We confirm a transition from an integrated stochastic process contaminated with electronic noise to a fractional Brownian motion with a Hurst exponent H=5/6 as the sampling time increases. Besides, we are able to quantify, from the estimated entropy, the amount of electronic noise as a function of the turbulence strength. We have also demonstrated that these experimental observations are in very good agreement with numerical simulations of noisy fractional Brownian motions with a well-defined crossover between two different scaling regimes.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn E. Melander

Over the last several decades, libraries across the nation have undergone dramatic budget cuts, despite being an important resource for regional and national economic growth and innovation. Numerous studies have attempted to show that libraries increase the intellectual level of users and contribute to the economic growth of communities through surveys and customer service data. Within this study, we have attempted to develop a more analytical method for assessing library performance, using the Idaho National Laboratory Research Library as a sample subject. We have developed a mathematical model to measure the financial value of a library’s material resources as wellmore » as its intellectual value to determine if the library is a positive contributor to the wider organization and community it serves.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)

Demmer, Rick; Fox, Don; Reese, Stephen

The Idaho National Laboratory (INL) and the United Kingdom (UK) National Nuclear Laboratory (NNL) have been collaborating for several years on materials and methods for the fogged/misted introduction of fixatives into radiologically contaminated facilities. The objective of the project is to deliver a process for reducing airborne radiological and/or mercury contamination and affixing loose contamination in place, thereby reducing contamination risk to employees and decreasing D&D cost and schedule. The developed process provides a reliable, unmanned method of introducing a coating that captures and fixes contamination in place within facilities. The INL coating, termed FX2, has undergone extensive non-radiological testing,more » including determination that it is non-flammable, affixes contamination and flows well through unusual geometries (testing at Florida International University). A series of non-active fogging trials for activity knock/tie-down application have been completed at NNL Workington on behalf of Idaho National Laboratory (INL). These trials performed by the NNL employed commercially available agricultural fogging equipment and the INL’s knock/tie-down latex formulation (FX-2). This testing successfully demonstrated the ability of the fogging devices to successfully spray the FX-2 formulation within various scenarios, and prepared the project for a radioactive trial. The INL has also developed a mercury vapor reducing form of the coating termed FX-Hg, which has shown great promise in laboratory studies.« less
Methods and Best Practice to Intercompare Dissolved Oxygen Sensors and Fluorometers/Turbidimeters for Oceanographic Applications.

PubMed

Pensieri, Sara; Bozzano, Roberto; Schiano, M Elisabetta; Ntoumas, Manolis; Potiris, Emmanouil; Frangoulis, Constantin; Podaras, Dimitrios; Petihakis, George

2016-05-17

In European seas, ocean monitoring strategies in terms of key parameters, space and time scale vary widely for a range of technical and economic reasons. Nonetheless, the growing interest in the ocean interior promotes the investigation of processes such as oxygen consumption, primary productivity and ocean acidity requiring that close attention is paid to the instruments in terms of measurement setup, configuration, calibration, maintenance procedures and quality assessment. To this aim, two separate hardware and software tools were developed in order to test and simultaneously intercompare several oxygen probes and fluorometers/turbidimeters, respectively in the same environmental conditions, with a configuration as close as possible to real in-situ deployment. The chamber designed to perform chlorophyll-a and turbidity tests allowed for the simultaneous acquisition of analogue and digital signals of several sensors at the same time, so it was sufficiently compact to be used in both laboratory and onboard vessels. Methodologies and best practice committed to the intercomparison of dissolved oxygen sensors and fluorometers/turbidimeters have been used, which aid in the promotion of interoperability to access key infrastructures, such as ocean observatories and calibration facilities. Results from laboratory tests as well as field tests in the Mediterranean Sea are presented.
Extreme Transients in the High Energy Universe

NASA Technical Reports Server (NTRS)

Kouveliotou, Chryssa

2013-01-01

The High Energy Universe is rich in diverse populations of objects spanning the entire cosmological (time)scale, from our own present-day Milky Way to the re-ionization epoch. Several of these are associated with extreme conditions irreproducible in laboratories on Earth. Their study thus sheds light on the behavior of matter under extreme conditions, such as super-strong magnetic fields (in excess of 10^14 G), high gravitational potentials (e.g., Super Massive Black Holes), very energetic collimated explosions resulting in relativistic jet flows (e.g., Gamma Ray Bursts, exceeding 10^53 ergs). In the last thirty years, my work has been mostly focused on two apparently different but potentially linked populations of such transients: magnetars (highly magnetized neutron stars) and Gamma Ray Bursts (strongly beamed emission from relativistic jets), two populations that constitute unique astrophysical laboratories, while also giving us the tools to probe matter conditions in the Universe to redshifts beyond z=10, when the first stars and galaxies were assembled. I did not make this journey alone I have either led or participated in several international collaborations studying these phenomena in multi-wavelength observations; solitary perfection is not sufficient anymore in the world of High Energy Astrophysics. I will describe this journey, present crucial observational breakthroughs, discuss key results and muse on the future of this field.
Fast parametric relationships for the large-scale reservoir simulation of mixed CH 4-CO 2 gas hydrate systems

DOE PAGES

Reagan, Matthew T.; Moridis, George J.; Seim, Katie S.

2017-03-27

A recent Department of Energy field test on the Alaska North Slope has increased interest in the ability to simulate systems of mixed CO 2-CH 4 hydrates. However, the physically realistic simulation of mixed-hydrate simulation is not yet a fully solved problem. Limited quantitative laboratory data leads to the use of various ab initio, statistical mechanical, or other mathematic representations of mixed-hydrate phase behavior. Few of these methods are suitable for inclusion in reservoir simulations, particularly for systems with large number of grid elements, 3D systems, or systems with complex geometric configurations. In this paper, we present a set ofmore » fast parametric relationships describing the thermodynamic properties and phase behavior of a mixed methane-carbon dioxide hydrate system. We use well-known, off-the-shelf hydrate physical properties packages to generate a sufficiently large dataset, select the most convenient and efficient mathematical forms, and fit the data to those forms to create a physical properties package suitable for inclusion in the TOUGH+ family of codes. Finally, the mapping of the phase and thermodynamic space reveals the complexity of the mixed-hydrate system and allows understanding of the thermodynamics at a level beyond what much of the existing laboratory data and literature currently offer.« less
Fast parametric relationships for the large-scale reservoir simulation of mixed CH4-CO2 gas hydrate systems

NASA Astrophysics Data System (ADS)

Reagan, Matthew T.; Moridis, George J.; Seim, Katie S.

2017-06-01

A recent Department of Energy field test on the Alaska North Slope has increased interest in the ability to simulate systems of mixed CO2-CH4 hydrates. However, the physically realistic simulation of mixed-hydrate simulation is not yet a fully solved problem. Limited quantitative laboratory data leads to the use of various ab initio, statistical mechanical, or other mathematic representations of mixed-hydrate phase behavior. Few of these methods are suitable for inclusion in reservoir simulations, particularly for systems with large number of grid elements, 3D systems, or systems with complex geometric configurations. In this work, we present a set of fast parametric relationships describing the thermodynamic properties and phase behavior of a mixed methane-carbon dioxide hydrate system. We use well-known, off-the-shelf hydrate physical properties packages to generate a sufficiently large dataset, select the most convenient and efficient mathematical forms, and fit the data to those forms to create a physical properties package suitable for inclusion in the TOUGH+ family of codes. The mapping of the phase and thermodynamic space reveals the complexity of the mixed-hydrate system and allows understanding of the thermodynamics at a level beyond what much of the existing laboratory data and literature currently offer.
Methods and Best Practice to Intercompare Dissolved Oxygen Sensors and Fluorometers/Turbidimeters for Oceanographic Applications

PubMed Central

Pensieri, Sara; Bozzano, Roberto; Schiano, M. Elisabetta; Ntoumas, Manolis; Potiris, Emmanouil; Frangoulis, Constantin; Podaras, Dimitrios; Petihakis, George

2016-01-01

In European seas, ocean monitoring strategies in terms of key parameters, space and time scale vary widely for a range of technical and economic reasons. Nonetheless, the growing interest in the ocean interior promotes the investigation of processes such as oxygen consumption, primary productivity and ocean acidity requiring that close attention is paid to the instruments in terms of measurement setup, configuration, calibration, maintenance procedures and quality assessment. To this aim, two separate hardware and software tools were developed in order to test and simultaneously intercompare several oxygen probes and fluorometers/turbidimeters, respectively in the same environmental conditions, with a configuration as close as possible to real in-situ deployment. The chamber designed to perform chlorophyll-a and turbidity tests allowed for the simultaneous acquisition of analogue and digital signals of several sensors at the same time, so it was sufficiently compact to be used in both laboratory and onboard vessels. Methodologies and best practice committed to the intercomparison of dissolved oxygen sensors and fluorometers/turbidimeters have been used, which aid in the promotion of interoperability to access key infrastructures, such as ocean observatories and calibration facilities. Results from laboratory tests as well as field tests in the Mediterranean Sea are presented. PMID:27196908
X-Ray Structure determination of the Glycine Cleavage System Protein H of Mycobacterium tuberculosis Using An Inverse Compton Synchrotron X-Ray Source

PubMed Central

Abendroth, Jan; McCormick, Michael S.; Edwards, Thomas E.; Staker, Bart; Loewen, Roderick; Gifford, Martin; Rifkin, Jeff; Mayer, Chad; Guo, Wenjin; Zhang, Yang; Myler, Peter; Kelley, Angela; Analau, Erwin; Hewitt, Stephen Nakazawa; Napuli, Alberto J.; Kuhn, Peter; Ruth, Ronald D.; Stewart, Lance J.

2010-01-01

Structural genomics discovery projects require ready access to both X-ray and NMR instrumentation which support the collection of experimental data needed to solve large numbers of novel protein structures. The most productive X-ray crystal structure determination laboratories make extensive frequent use of tunable synchrotron X-ray light to solve novel structures by anomalous diffraction methods. This requires that frozen cryo-protected crystals be shipped to large government-run synchrotron facilities for data collection. In an effort to eliminate the need to ship crystals for data collection, we have developed the first laboratory-scale synchrotron light source capable of performing many of the state-of-the-art synchrotron applications in X-ray science. This Compact Light Source is a first-in-class device that uses inverse Compton scattering to generate X-rays of sufficient flux, tunable wavelength and beam size to allow high-resolution X-ray diffraction data collection from protein crystals. We report on benchmarking tests of X-ray diffraction data collection with hen egg white lysozyme, and the successful high-resolution X-ray structure determination of the Glycine cleavage system protein H from Mycobacterium tuberculosis using diffraction data collected with the Compact Light Source X-ray beam. PMID:20364333
Extruder system for high-throughput/steady-state hydrogen ice supply and application for pellet fueling of reactor-scale fusion experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Combs, S.K.; Foust, C.R.; Qualls, A.L.

Pellet injection systems for the next-generation fusion devices, such as the proposed International Thermonuclear Experimental Reactor (ITER), will require feed systems capable of providing a continuous supply of hydrogen ice at high throughputs. A straightforward concept in which multiple extruder units operate in tandem has been under development at the Oak Ridge National Laboratory. A prototype with three large-volume extruder units has been fabricated and tested in the laboratory. In experiments, it was found that each extruder could provide volumetric ice flow rates of up to {approximately}1.3 cm{sup 3}/s (for {approximately}10 s), which is sufficient for fueling fusion reactors atmore » the gigawatt power level. With the three extruders of the prototype operating in sequence, a steady rate of {approximately}0.33 cm{sup 3}/s was maintained for a duration of 1 h. Even steady-state rates approaching the full ITER design value ({approximately}1 cm{sup 3}/s) may be feasible with the prototype. However, additional extruder units (1{endash}3) would facilitate operations at the higher throughputs and reduce the duty cycle of each unit. The prototype can easily accommodate steady-state pellet fueling of present large tokamaks or other near-term plasma experiments.« less
Fast parametric relationships for the large-scale reservoir simulation of mixed CH 4-CO 2 gas hydrate systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reagan, Matthew T.; Moridis, George J.; Seim, Katie S.

A recent Department of Energy field test on the Alaska North Slope has increased interest in the ability to simulate systems of mixed CO 2-CH 4 hydrates. However, the physically realistic simulation of mixed-hydrate simulation is not yet a fully solved problem. Limited quantitative laboratory data leads to the use of various ab initio, statistical mechanical, or other mathematic representations of mixed-hydrate phase behavior. Few of these methods are suitable for inclusion in reservoir simulations, particularly for systems with large number of grid elements, 3D systems, or systems with complex geometric configurations. In this paper, we present a set ofmore » fast parametric relationships describing the thermodynamic properties and phase behavior of a mixed methane-carbon dioxide hydrate system. We use well-known, off-the-shelf hydrate physical properties packages to generate a sufficiently large dataset, select the most convenient and efficient mathematical forms, and fit the data to those forms to create a physical properties package suitable for inclusion in the TOUGH+ family of codes. Finally, the mapping of the phase and thermodynamic space reveals the complexity of the mixed-hydrate system and allows understanding of the thermodynamics at a level beyond what much of the existing laboratory data and literature currently offer.« less
Predictive modelling of flow in a two-dimensional intermediate-scale, heterogeneous porous media

USGS Publications Warehouse

Barth, Gilbert R.; Hill, M.C.; Illangasekare, T.H.; Rajaram, H.

2000-01-01

To better understand the role of sedimentary structures in flow through porous media, and to determine how small-scale laboratory-measured values of hydraulic conductivity relate to in situ values this work deterministically examines flow through simple, artificial structures constructed for a series of intermediate-scale (10 m long), two-dimensional, heterogeneous, laboratory experiments. Nonlinear regression was used to determine optimal values of in situ hydraulic conductivity, which were compared to laboratory-measured values. Despite explicit numerical representation of the heterogeneity, the optimized values were generally greater than the laboratory-measured values. Discrepancies between measured and optimal values varied depending on the sand sieve size, but their contribution to error in the predicted flow was fairly consistent for all sands. Results indicate that, even under these controlled circumstances, laboratory-measured values of hydraulic conductivity need to be applied to models cautiously.To better understand the role of sedimentary structures in flow through porous media, and to determine how small-scale laboratory-measured values of hydraulic conductivity relate to in situ values this work deterministically examines flow through simple, artificial structures constructed for a series of intermediate-scale (10 m long), two-dimensional, heterogeneous, laboratory experiments. Nonlinear regression was used to determine optimal values of in situ hydraulic conductivity, which were compared to laboratory-measured values. Despite explicit numerical representation of the heterogeneity, the optimized values were generally greater than the laboratory-measured values. Discrepancies between measured and optimal values varied depending on the sand sieve size, but their contribution to error in the predicted flow was fairly consistent for all sands. Results indicate that, even under these controlled circumstances, laboratory-measured values of hydraulic conductivity need to be applied to models cautiously.
Psychometric appraisal of the Scale for Interpersonal Behavior (SIB) in France.

PubMed

Bouvard, M; Arrindell, W A; Guérin, J; Bouchard, C; Rion, A C; Ducottet, E; Séchaud, M; Mollard, E; Grillet, P R; Dang, C; Cottraux, J

1999-08-01

The present study was carried out in France to evaluate the reliability and validity of the Scale for Interpersonal Behavior (SIB), a multidimensional measure of difficulty and distress in assertiveness that was originally developed in The Netherlands. This appraisal was conducted with a clinical sample (N = 166) and a general population sample (N = 150). The clinical series comprised 115 patients with social phobia and 51 patients with personality disorder, 28 of whom were of the avoidant type. Support was found for internal consistency and test-retest reliability of the French SIB. Compared to controls, both social phobics and patients with an avoidant personality disorder had significantly lower mean scores on all performance scales and significantly higher ones on all distress scales, with the social phobics occupying a position in between. Findings in relation to convergent and divergent validity were quite satisfactory. Sensitivity of the French SIB for detecting change was demonstrated in a subgroup of the clinical Ss who had undergone 15 sessions of cognitive-behavioral group therapy for underassertiveness.
Final Project Report: Release of aged contaminants from weathered sediments: Effects of sorbate speciation on scaling of reactive transport

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jon Chorover, University of Arizona; Peggy O'ÃÂÃÂDay, University of California, Merced; Karl Mueller, Penn State University

2012-10-01

Hanford sediments impacted by hyperalkaline high level radioactive waste have undergone incongruent silicate mineral weathering concurrent with contaminant uptake. In this project, we studied the impact of background pore water (BPW) on strontium, cesium and iodine desorption and transport in Hanford sediments that were experimentally weathered by contact with simulated hyperalkaline tank waste leachate (STWL) solutions. Using those lab-weathered Hanford sediments (HS) and model precipitates formed during nucleation from homogeneous STWL solutions (HN), we (i) provided detailed characterization of reaction products over a matrix of field-relevant gradients in contaminant concentration, PCO2, and reaction time; (ii) improved molecular-scale understanding of howmore » sorbate speciation controls contaminant desorption from weathered sediments upon removal of caustic sources; and (iii) developed a mechanistic, predictive model of meso- to field-scale contaminant reactive transport under these conditions.« less
Plant Biodiversity Change Across Scales During the Anthropocene.

PubMed

Vellend, Mark; Baeten, Lander; Becker-Scarpitta, Antoine; Boucher-Lalonde, Véronique; McCune, Jenny L; Messier, Julie; Myers-Smith, Isla H; Sax, Dov F

2017-04-28

Plant communities have undergone dramatic changes in recent centuries, although not all such changes fit with the dominant biodiversity-crisis narrative used to describe them. At the global scale, future declines in plant species diversity are highly likely given habitat conversion in the tropics, although few extinctions have been documented for the Anthropocene to date (<0.1%). Nonnative species introductions have greatly increased plant species richness in many regions of the world at the same time that they have led to the creation of new hybrid polyploid species by bringing previously isolated congeners into close contact. At the local scale, conversion of primary vegetation to agriculture has decreased plant diversity, whereas other drivers of change-e.g., climate warming, habitat fragmentation, and nitrogen deposition-have highly context-dependent effects, resulting in a distribution of temporal trends with a mean close to zero. These results prompt a reassessment of how conservation goals are defined and justified.
Application of simultaneous saccharification and fermentation (SSF) from viscosity reducing of raw sweet potato for bioethanol production at laboratory, pilot and industrial scales.

PubMed

Zhang, Liang; Zhao, Hai; Gan, Mingzhe; Jin, Yanlin; Gao, Xiaofeng; Chen, Qian; Guan, Jiafa; Wang, Zhongyan

2011-03-01

The aim of this work was to research a bioprocess for bioethanol production from raw sweet potato by Saccharomyces cerevisiae at laboratory, pilot and industrial scales. The fermentation mode, inoculum size and pressure from different gases were determined in laboratory. The maximum ethanol concentration, average ethanol productivity rate and yield of ethanol after fermentation in laboratory scale (128.51 g/L, 4.76 g/L/h and 91.4%) were satisfactory with small decrease at pilot scale (109.06 g/L, 4.89 g/L/h and 91.24%) and industrial scale (97.94 g/L, 4.19 g/L/h and 91.27%). When scaled up, the viscosity caused resistance to fermentation parameters, 1.56 AUG/g (sweet potato mash) of xylanase decreased the viscosity from approximately 30000 to 500 cp. Overall, sweet potato is a attractive feedstock for be bioethanol production from both the economic standpoints and environmentally friendly. Copyright © 2011 Elsevier Ltd. All rights reserved.
Low-Cost alpha Alane for Hydrogen Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fabian, Tibor; Petrie, Mark; Crouch-Baker, Steven

This project was directed towards the further development of the Savannah River National Laboratory (SRNL) lab-scale electrochemical synthesis of the hydrogen storage material alpha-alane and Ardica Technologies-SRI International (SRI) chemical downstream processes that are necessary to meet DoE cost metrics and transition alpha-alane synthesis to an industrial scale. Ardica has demonstrated the use of alpha-alane in a fuel-cell system for the U.S. Army WFC20 20W soldier power system that has successfully passed initial field trials with individual soldiers. While alpha-alane has been clearly identified as a desirable hydrogen storage material, cost-effective means for its production and regeneration on a scalemore » of use applicable to the industry have yet to be established. We focused on three, principal development areas: 1. The construction of a comprehensive engineering techno-economic model to establish the production costs of alpha-alane by both electrochemical and chemical routes at scale. 2. The identification of critical, cost-saving design elements of the electrochemical cell and the quantification of the product yields of the primary electrochemical process. A moving particle-bed reactor design was constructed and operated. 3. The experimental quantification of the product yields of candidate downstream chemical processes necessary to produce alpha-alane to complete the most cost-effective overall manufacturing process. Our techno-economic model shows that under key assumptions most 2015 and 2020 DOE hydrogen storage system cost targets for low and medium power can be achieved using the electrochemical alane synthesis process. To meet the most aggressive 2020 storage system cost target, $1/g, our model indicates that 420 metric tons per year (MT/y) production of alpha-alane is required. Laboratory-scale experimental work demonstrated that the yields of two of the three critical component steps within the overall “electrochemical process” were sufficiently high to meet this production target. In the case of the yield of the third step, the crystallization of alpha-alane from the primary alane-related product of the electrochemical reaction, further development is required.« less
Digital Holographic Microscopy, a Method for Detection of Microorganisms in Plume Samples from Enceladus and Other Icy Worlds

PubMed Central

Bedrossian, Manuel; Lindensmith, Chris

2017-01-01

Abstract Detection of extant microbial life on Earth and elsewhere in the Solar System requires the ability to identify and enumerate micrometer-scale, essentially featureless cells. On Earth, bacteria are usually enumerated by culture plating or epifluorescence microscopy. Culture plates require long incubation times and can only count culturable strains, and epifluorescence microscopy requires extensive staining and concentration of the sample and instrumentation that is not readily miniaturized for space. Digital holographic microscopy (DHM) represents an alternative technique with no moving parts and higher throughput than traditional microscopy, making it potentially useful in space for detection of extant microorganisms provided that sufficient numbers of cells can be collected. Because sample collection is expected to be the limiting factor for space missions, especially to outer planets, it is important to quantify the limits of detection of any proposed technique for extant life detection. Here we use both laboratory and field samples to measure the limits of detection of an off-axis digital holographic microscope (DHM). A statistical model is used to estimate any instrument's probability of detection at various bacterial concentrations based on the optical performance characteristics of the instrument, as well as estimate the confidence interval of detection. This statistical model agrees well with the limit of detection of 103 cells/mL that was found experimentally with laboratory samples. In environmental samples, active cells were immediately evident at concentrations of 104 cells/mL. Published estimates of cell densities for Enceladus plumes yield up to 104 cells/mL, which are well within the off-axis DHM's limits of detection to confidence intervals greater than or equal to 95%, assuming sufficient sample volumes can be collected. The quantitative phase imaging provided by DHM allowed minerals to be distinguished from cells. Off-axis DHM's ability for rapid low-level bacterial detection and counting shows its viability as a technique for detection of extant microbial life provided that the cells can be captured intact and delivered to the sample chamber in a sufficient volume of liquid for imaging. Key Words: In situ life detection—Extant microorganisms—Holographic microscopy—Ocean Worlds—Enceladus—Imaging. Astrobiology 17, 913–925. PMID:28708412

DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.

PubMed

Yelina, Nataliya E; Lambing, Christophe; Hardcastle, Thomas J; Zhao, Xiaohui; Santos, Bruno; Henderson, Ian R

2015-10-15

During meiosis, homologous chromosomes undergo crossover recombination, which is typically concentrated in narrow hot spots that are controlled by genetic and epigenetic information. Arabidopsis chromosomes are highly DNA methylated in the repetitive centromeres, which are also crossover-suppressed. Here we demonstrate that RNA-directed DNA methylation is sufficient to locally silence Arabidopsis euchromatic crossover hot spots and is associated with increased nucleosome density and H3K9me2. However, loss of CG DNA methylation maintenance in met1 triggers epigenetic crossover remodeling at the chromosome scale, with pericentromeric decreases and euchromatic increases in recombination. We used recombination mutants that alter interfering and noninterfering crossover repair pathways (fancm and zip4) to demonstrate that remodeling primarily involves redistribution of interfering crossovers. Using whole-genome bisulfite sequencing, we show that crossover remodeling is driven by loss of CG methylation within the centromeric regions. Using cytogenetics, we profiled meiotic DNA double-strand break (DSB) foci in met1 and found them unchanged relative to wild type. We propose that met1 chromosome structure is altered, causing centromere-proximal DSBs to be inhibited from maturation into interfering crossovers. These data demonstrate that DNA methylation is sufficient to silence crossover hot spots and plays a key role in establishing domains of meiotic recombination along chromosomes. © 2015 Yelina et al.; Published by Cold Spring Harbor Laboratory Press.
Accurate Radiometry from Space: An Essential Tool for Climate Studies

NASA Technical Reports Server (NTRS)

Fox, Nigel; Kaiser-Weiss, Andrea; Schmutz, Werner; Thome, Kurtis; Young, Dave; Wielicki, Bruce; Winkler, Rainer; Woolliams, Emma

2011-01-01

The Earth s climate is undoubtedly changing; however, the time scale, consequences and causal attribution remain the subject of significant debate and uncertainty. Detection of subtle indicators from a background of natural variability requires measurements over a time base of decades. This places severe demands on the instrumentation used, requiring measurements of sufficient accuracy and sensitivity that can allow reliable judgements to be made decades apart. The International System of Units (SI) and the network of National Metrology Institutes were developed to address such requirements. However, ensuring and maintaining SI traceability of sufficient accuracy in instruments orbiting the Earth presents a significant new challenge to the metrology community. This paper highlights some key measurands and applications driving the uncertainty demand of the climate community in the solar reflective domain, e.g. solar irradiances and reflectances/radiances of the Earth. It discusses how meeting these uncertainties facilitate significant improvement in the forecasting abilities of climate models. After discussing the current state of the art, it describes a new satellite mission, called TRUTHS, which enables, for the first time, high-accuracy SI traceability to be established in orbit. The direct use of a primary standard and replication of the terrestrial traceability chain extends the SI into space, in effect realizing a metrology laboratory in space . Keywords: climate change; Earth observation; satellites; radiometry; solar irradiance
Oocyte vitrification for elective fertility preservation: the past, present, and future.

PubMed

Gunnala, Vinay; Schattman, Glenn

2017-02-01

Oocyte cryopreservation is no longer experimental and one of its rapidly growing indications is elective fertility preservation. Currently there is no sufficient evidence to support its practice and therefore its place in IVF remains uncertain. Vitrification has superior post-thaw survival and fertilization outcomes compared with oocytes that were frozen with the slow-freeze technique. Oocyte vitrification produces similar IVF outcomes compared with fresh oocytes and is not associated with further obstetrical or perinatal morbidity. Undergoing elective oocyte cryopreservation between ages 35 and 37 will optimize live birth rates as well as cost effectiveness from mathematical models. In women who delay child bearing, elective oocyte cryopreservation in the mid 30s may be beneficial in terms of live birth rates and cost effectiveness. Prospective studies of women who have undergone oocyte cryopreservation and are now attempting conception are needed before official recommendations can be made regarding elective egg freezing.
Research as due diligence: What can supply-side interventions accomplish and at what cost?

PubMed

Greenfield, Victoria A; Paoli, Letizia

2017-03-01

Supply-side interventions, which we define as laws, regulations, enforcement activities, and other measures that extend from drug production to dealing, feature prominently in drug policy and related expenditures internationally, but have undergone relatively little rigorous, empirical evaluation. We argue for filling the knowledge gap and highlight three areas of particular concern: first, the policy community knows less than it should about the efficacy of supply-side interventions; second, it lacks sufficient understanding of the scope, magnitude, and practical implications of adverse consequences that accompany such interventions; third, it lacks tools to gauge the balance of benefits and costs, both monetary and non-monetary. Our interest has been in developing a harm-based approach to address these concerns and we put forward a "harm assessment framework" for that purpose. Copyright © 2017 Elsevier B.V. All rights reserved.
Nuclear Forensics at Los Alamos National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kinman, William Scott; Steiner, Robert Ernest; Lamont, Stephen Philip

Nuclear forensics assists in responding to any event where nuclear material is found outside of regulatory control; a response plan is presented and a nuclear forensics program is undergoing further development so that smugglers are sufficiently deterred.
Development of a liquid xenon time projection chamber for the XENON dark matter search

NASA Astrophysics Data System (ADS)

Ni, Kaixuan

This thesis describes the research conducted for the XENON dark matter direct detection experiment. The tiny energy and small cross-section, from the interaction of dark matter particle on the target, requires a low threshold and sufficient background rejection capability of the detector. The XENON experiment uses dual phase technology to detect scintillation and ionization simultaneously from an event in liquid xenon (LXe). The distinct ratio, between scintillation and ionization, for nuclear recoil and electron recoil events provides excellent background rejection potential. The XENON detector is designed to have 3D position sensitivity down to mm scale, which provides additional event information for background rejection. Started in 2002, the XENON project made steady progress in the R&D phase during the past few years. Those include developing sensitive photon detectors in LXe, improving the energy resolution and LXe purity for detecting very low energy events. Two major quantities related to the dark matter detection, the scintillation efficiency and ionization yield of nuclear recoils in LXe, have been established. A prototype dual phase detector (XENON3) has been built and tested extensively in above ground laboratory. The 3D position sensitivity, as well as the background discrimination potential demonstrated from the XENON3 prototype, allows the construction of a 10 kg scale detector (XENON10), to be deployed underground in early 2006. With 99.5% electron recoil rejection efficiency and 16 keVr nuclear recoil energy threshold, XENON10 will be able to probe the WIMP-nucleon cross-section down to 2 x 10-44 cm2 in the supersymmetry parameter space, after one month operation in the Gran Sasso underground laboratory.
Evaluation of a laboratory-scale bioreactive in situ sediment cap for the treatment of organic contaminants.

PubMed

Himmelheber, David W; Pennell, Kurt D; Hughes, Joseph B

2011-11-01

The development of bioreactive sediment caps, in which microorganisms capable of contaminant transformation are placed within an in situ cap, provides a potential remedial design that can sustainably treat sediment and groundwater contaminants. The goal of this study was to evaluate the ability and limitations of a mixed, anaerobic dechlorinating consortium to treat chlorinated ethenes within a sand-based cap. Results of batch experiments demonstrate that a tetrachloroethene (PCE)-to-ethene mixed consortium was able to completely dechlorinate dissolved-phase PCE to ethene when supplied only with sediment porewater obtained from a sediment column. To simulate a bioreactive cap, laboratory-scale sand columns inoculated with the mixed culture were placed in series with an upflow sediment column and directly supplied sediment effluent and dissolved-phase chlorinated ethenes. The mixed consortium was not able to sustain dechlorination activity at a retention time of 0.5 days without delivery of amendments to the sediment effluent, evidenced by the loss of cis-1,2-dichloroethene (cis-DCE) dechlorination to vinyl chloride. When soluble electron donor was supplied to the sediment effluent, complete dechlorination of cis-DCE to ethene was observed at retention times of 0.5 days, suggesting that sediment effluent lacked sufficient electron donor to maintain active dechlorination within the sediment cap. Introduction of elevated contaminant concentrations also limited biotransformation performance of the dechlorinating consortium within the cap. These findings indicate that in situ bioreactive capping can be a feasible remedial approach, provided that residence times are adequate and that appropriate levels of electron donor and contaminant exist within the cap. Copyright © 2011 Elsevier Ltd. All rights reserved.
Biodegradation modelling of a dissolved gasoline plume applying independent laboratory and field parameters

NASA Astrophysics Data System (ADS)

Schirmer, Mario; Molson, John W.; Frind, Emil O.; Barker, James F.

2000-12-01

Biodegradation of organic contaminants in groundwater is a microscale process which is often observed on scales of 100s of metres or larger. Unfortunately, there are no known equivalent parameters for characterizing the biodegradation process at the macroscale as there are, for example, in the case of hydrodynamic dispersion. Zero- and first-order degradation rates estimated at the laboratory scale by model fitting generally overpredict the rate of biodegradation when applied to the field scale because limited electron acceptor availability and microbial growth are not considered. On the other hand, field-estimated zero- and first-order rates are often not suitable for predicting plume development because they may oversimplify or neglect several key field scale processes, phenomena and characteristics. This study uses the numerical model BIO3D to link the laboratory and field scales by applying laboratory-derived Monod kinetic degradation parameters to simulate a dissolved gasoline field experiment at the Canadian Forces Base (CFB) Borden. All input parameters were derived from independent laboratory and field measurements or taken from the literature a priori to the simulations. The simulated results match the experimental results reasonably well without model calibration. A sensitivity analysis on the most uncertain input parameters showed only a minor influence on the simulation results. Furthermore, it is shown that the flow field, the amount of electron acceptor (oxygen) available, and the Monod kinetic parameters have a significant influence on the simulated results. It is concluded that laboratory-derived Monod kinetic parameters can adequately describe field scale degradation, provided all controlling factors are incorporated in the field scale model. These factors include advective-dispersive transport of multiple contaminants and electron acceptors and large-scale spatial heterogeneities.
Gender equality and human rights approaches to female genital mutilation: a review of international human rights norms and standards.

PubMed

Khosla, Rajat; Banerjee, Joya; Chou, Doris; Say, Lale; Fried, Susana T

2017-05-12

Two hundred million girls and women in the world are estimated to have undergone female genital mutilation (FGM), and another 15 million girls are at risk of experiencing it by 2020 in high prevalence countries (UNICEF, 2016. Female genital mutilation/cutting: a global concern. 2016). Despite decades of concerted efforts to eradicate or abandon the practice, and the increased need for clear guidance on the treatment and care of women who have undergone FGM, present efforts have not yet been able to effectively curb the number of women and girls subjected to this practice (UNICEF. Female genital mutilation/cutting: a statistical overview and exploration of the dynamics of change. 2013), nor are they sufficient to respond to health needs of millions of women and girls living with FGM. International efforts to address FGM have thus far focused primarily on preventing the practice, with less attention to treating associated health complications, caring for survivors, and engaging health care providers as key stakeholders. Recognizing this imperative, WHO developed guidelines on management of health complications of FGM. In this paper, based on foundational research for the development of WHO's guidelines, we situate the practice of FGM as a rights violation in the context of international and national policy and efforts, and explore the role of health providers in upholding health-related human rights of women at girls who are survivors, or who are at risk. Findings are based on a literature review of relevant international human rights treaties and UN Treaty Monitoring Bodies.
Stable isotope analyses of the peralkaline volcanics Gregory Rift Valley, Kenya

NASA Technical Reports Server (NTRS)

Black, S.; Macdonald, R.; Fallick, A. E.; Kelly, M.

1993-01-01

Delta O-18 analyses of the Naivasha rhyolites, basalts, Menengai trachytes and the Yatta phonolite are presented together with D/H analyses of the Naivasha rhyolites. Delta O-18 results vary from 5.7 to 8.9 per mill which is within the reported range of delta O-18 analyses for continental volcanics. Closure temperatures calulated from the basalts and rhyolites show equilibration to be at magmatic temperatures. D/H values range from -40 to -148 per mill indicating that the rhyolites have undergone large scale degasssing.
Multi-time scale dynamics in power electronics-dominated power systems

NASA Astrophysics Data System (ADS)

Yuan, Xiaoming; Hu, Jiabing; Cheng, Shijie

2017-09-01

Electric power infrastructure has recently undergone a comprehensive transformation from electromagnetics to semiconductors. Such a development is attributed to the rapid growth of power electronic converter applications in the load side to realize energy conservation and on the supply side for renewable generations and power transmissions using high voltage direct current transmission. This transformation has altered the fundamental mechanism of power system dynamics, which demands the establishment of a new theory for power system control and protection. This paper presents thoughts on a theoretical framework for the coming semiconducting power systems.
A current perspective on antimicrobial resistance in Southeast Asia

PubMed Central

Zellweger, Raphaël M; Carrique-Mas, Juan; Limmathurotsakul, Direk; Day, Nicholas P. J; Thwaites, Guy E; Baker, Stephen; Ashley, Elizabeth; de Balogh, Katinka; Baird, Kevin; Basnyat, Buddha; Benigno, Carolyne; Bodhidatta, Ladaporn; Chantratita, Narisara; Cooper, Ben; Dance, David; Dhorda, Mehul; van Doorn, Rogier; Dougan, Gordon; Hoa, Ngo Thi; Ip, Margaret; Lawley, Trevor; Lim, Cherry; Lin, Thong Kwai; Ling, Claire; Lubell, Yoel; Mather, Alison; Marks, Florian; Mohan, Venkata Raghava; Newton, Paul; Paris, Daniel; Thomson, Nicholas; Turner, Paul; Serichantalergs, Oralak; Smithuis, Frank; Wuthiekanun, Vanaporn; White, Nicholas; Li Yang, Hsu

2017-01-01

Abstract Southeast Asia, a vibrant region that has recently undergone unprecedented economic development, is regarded as a global hotspot for the emergence and spread of antimicrobial resistance (AMR). Understanding AMR in Southeast Asia is crucial for assessing how to control AMR on an international scale. Here we (i) describe the current AMR situation in Southeast Asia, (ii) explore the mechanisms that make Southeast Asia a focal region for the emergence of AMR, and (iii) propose ways in which Southeast Asia could contribute to a global solution. PMID:28961709
Vertical motions in the Uranian atmosphere - An analysis of radio observations

NASA Technical Reports Server (NTRS)

Hofstadter, Mark D.; Berge, Glenn L.; Muhleman, Duane O.

1990-01-01

The present, 6-cm radio map of Uranus indicates latitudinal features which may be due to vertical motions of the atmosphere. It appears in light of Voyager IR measurements as well as previously obtained radio data that these large-scale vertical motions, which have not undergone significant changes over the course of 8 years, extend from the 0.1- to the 45-bar levels; this span corresponds to a height of the order of 250 km. The latitudinal structures are believed to be primarily caused by horizontal variations of absorber abundances.
A Controllable Earthquake Rupture Experiment on the Homestake Fault

NASA Astrophysics Data System (ADS)

Germanovich, L. N.; Murdoch, L. C.; Garagash, D.; Reches, Z.; Martel, S. J.; Gwaba, D.; Elsworth, D.; Lowell, R. P.; Onstott, T. C.

2010-12-01

Fault-slip is typically simulated in the laboratory at the cm-to-dm scale. Laboratory results are then up-scaled by orders of magnitude to understand faulting and earthquakes processes. We suggest an experimental approach to reactivate faults in-situ at scales ~10-100 m using thermal techniques and fluid injection to modify in situ stresses and the fault strength to the point where the rock fails. Mines where the modified in-situ stresses are sufficient to drive faulting, present an opportunity to conduct such experiments. During our recent field work in the former Homestake gold mine in the northern Black Hills, South Dakota, we found a large fault present on multiple mine levels. The fault is subparallel to the local foliation in the Poorman formation, a Proterozoic metamorphic rock deformed into regional-scale folds with axes plunging ~40° to the SSE. The fault extends at least 1.5 km along strike and dip, with a center ~1.5 km deep. It strikes ~320-340° N, dips ~45-70° NE, and is recognized by a ~0.3-0.5 m thick distinct gouge that contains crushed host rock and black material that appears to be graphite. Although we could not find clear evidence for fault displacement, secondary features suggest that it is a normal fault. The size and distinct structure of this fault make it a promising target for in-situ experimentation of fault strength, hydrological properties, and slip nucleation processes. Most earthquakes are thought to be the result of unstable slip on existing faults, Activation of the Homestake fault in response to the controlled fluid injection and thermally changing background stresses is likely to be localized on a crack-like patch. Slow patch propagation, moderated by the injection rate and the rate of change of the background stresses, may become unstable, leading to the nucleation of a small earthquake (dynamic) rupture. This controlled instability is intimately related to the dependence of the fault strength on the slip process and has been analyzed for the Homestake fault conditions. Scale analyses indicate that this transition occurs for the nucleation patch size ~1 m. This represents a fundamental limitation for laboratory experiments, where the induced dynamic patch could be tractable, and necessitates larger scale field tests ~10-100 m. The ongoing dewatering is expected to affect displacements in the fault vicinity. This poroelastic effect can be used to better characterize the fault. Nucleation, propagation, and arrest of dynamic fault slip is governed by fluid overpressure source, diffusion, and the magnitude of the background loading in relation to the peak and residual strength in the fault zone at the ambient pore pressure level. More information on in-situ stresses than currently available is required to evaluate the fault state. Yet, initial modeling suggests that a suitable place for such an experiment is where the Homestake fault intersects the 4850-ft mine level or at greater depths.
Prediction of SOC content by Vis-NIR spectroscopy at European scale using a modified local PLS algorithm

NASA Astrophysics Data System (ADS)

Nocita, M.; Stevens, A.; Toth, G.; van Wesemael, B.; Montanarella, L.

2012-12-01

In the context of global environmental change, the estimation of carbon fluxes between soils and the atmosphere has been the object of a growing number of studies. This has been motivated notably by the possibility to sequester CO2 into soils by increasing the soil organic carbon (SOC) stocks and by the role of SOC in maintaining soil quality. Spatial variability of SOC masks its slow accumulation or depletion, and the sampling density required to detect a change in SOC content is often very high and thus very expensive and labour intensive. Visible near infrared diffuse reflectance spectroscopy (Vis-NIR DRS) has been shown to be a fast, cheap and efficient tool for the prediction of SOC at fine scales. However, when applied to regional or country scales, Vis-NIR DRS did not provide sufficient accuracy as an alternative to standard laboratory soil analysis for SOC monitoring. Under the framework of Land Use/Cover Area Frame Statistical Survey (LUCAS) project of the European Commission's Joint Research Centre (JRC), about 20,000 samples were collected all over European Union. Soil samples were analyzed for several physical and chemical parameters, and scanned with a Vis-NIR spectrometer in the same laboratory. The scope of our research was to predict SOC content at European scale using LUCAS spectral library. We implemented a modified local partial least square regression (l-PLS) including, in addition to spectral distance, other potentially useful covariates (geography, texture, etc.) to select for each unknown sample a group of predicting neighbours. The dataset was split in mineral soils under cropland, mineral soils under grassland, mineral soils under woodland, and organic soils due to the extremely diverse spectral response of the four classes. Four every class training (70%) and test (30%) sets were created to calibrate and validate the SOC prediction models. The results showed very good prediction ability for mineral soils under cropland and mineral soils under grassland, with a root mean square error (RMSE) of 3.6 and 7.2 g C kg-1 respectively, while mineral soils under woodland and organic soils predictions were less accurate (RMSE of 11.9 and 51.1 g C kg-1). The RMSE was lower (except for organic soils) when sand content was used as covariate in the selection of the l-PLS predicting neighbours. The obtained results proved that: (i) Although the enormous spatial variability of European soils, the developed modified l-PLS algorithm was able to produce stable calibrations and accurate predictions. (ii) It is essential to invest in spectral libraries built according to sampling strategies, based on soil types, and a standardized laboratory protocol. (iii) Vis-NIR DRS spectroscopy is a powerful and cost effective tool to predict SOC content at regional/continental scales, and should be converted from a pure research discipline into a reference operational method decreasing the uncertainties of SOC monitoring and terrestrial ecosystems carbon fluxes at all scales.
The prospects of transition metal dichalcogenides for ultimately scaled CMOS

NASA Astrophysics Data System (ADS)

Thiele, S.; Kinberger, W.; Granzner, R.; Fiori, G.; Schwierz, F.

2018-05-01

MOSFET gate length scaling has been a main source of progress in digital electronics for decades. Today, researchers still spend considerable efforts on reducing the gate length and on developing ultimately scaled MOSFETs, thereby exploring both new device architectures and alternative channel materials beyond Silicon such as two-dimensional TMDs (transition metal dichalcogenide). On the other hand, the envisaged scaling scenario for the next 15 years has undergone a significant change recently. While the 2013 ITRS edition required a continuation of aggressive gate length scaling for at least another 15 years, the 2015 edition of the ITRS suggests a deceleration and eventually a levelling off of gate length scaling and puts more emphasis on alternative options such as pitch scaling to keep Moore's Law alive. In the present paper, future CMOS scaling is discussed in the light of emerging two-dimensional MOSFET channel, in particular two-dimensional TMDs. To this end, the scaling scenarios of the 2013 and 2015 ITRS editions are considered and the scaling potential of TMD MOSFETs is investigated by means of quantum-mechanical device simulations. It is shown that for ultimately scaled MOSFETs as required in the 2013 ITRS, the heavy carrier effective masses of the Mo- and W-based TMDs are beneficial for the suppression of direct source-drain tunneling, while to meet the significantly relaxed scaling targets of the 2016 ITRS heavy-effective-mass channels are not needed.
Pretreatment Engineering Platform Phase 1 Final Test Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurath, Dean E.; Hanson, Brady D.; Minette, Michael J.

2009-12-23

Pacific Northwest National Laboratory (PNNL) was tasked by Bechtel National Inc. (BNI) on the River Protection Project, Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to conduct testing to demonstrate the performance of the WTP Pretreatment Facility (PTF) leaching and ultrafiltration processes at an engineering-scale. In addition to the demonstration, the testing was to address specific technical issues identified in Issue Response Plan for Implementation of External Flowsheet Review Team (EFRT) Recommendations - M12, Undemonstrated Leaching Processes.( ) Testing was conducted in a 1/4.5-scale mock-up of the PTF ultrafiltration system, the Pretreatment Engineering Platform (PEP). Parallel laboratory testing wasmore » conducted in various PNNL laboratories to allow direct comparison of process performance at an engineering-scale and a laboratory-scale. This report presents and discusses the results of those tests.« less
Laboratory and field evaluation of concrete paving curing effectiveness.

DOT National Transportation Integrated Search

2009-12-01

Ensuring that sufficient water is available in hydrating concrete is of great importance to produce durable : concrete and achieve both short- and long-term performance of concrete pavement. Excessive early-age : evaporation from the surface of concr...
Uranium hydrogeochemical and stream sediment reconnaissance of the Solomon NTMS quadrangle, Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langfeldt, S.L.; Youngquist, C.A.; D'Andrea, R.F. Jr.

This report presents results of a Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) of the Solomon NTMS quadrangle, Alaska. In addition to this abbreviated data release, more complete data are available to the public in machine-readable form through the Grand Junction Office Information System at Oak Ridge National Laboratory. Presented in this data release are location data, field analyses, and laboratory analyses of several different sample media. For the sake of brevity, many field site observations have not been included in this volume. These data are, however, available on the magnetic tape. Appendices A and B describe the sample media andmore » summarize the analytical results for each medium. The data were subdivided by one of the Los Alamos National Laboratory (LANL) sorting programs of Zinkl and others into groups of stream sediment and stream water samples. For each group which contains a sufficient number of observations, statistical tables, tables of raw data, and 1:1000000 scale maps of pertinent elements have been included in this report. In addition, maps showing results of multivariate statistical analyses have been included. Further information about the HSSR program in general, or about the LANL portion of the program in particular, can be obtained in quarterly or semiannual program progress reports on open-file at DOE's Technical Library in Grand Junction. Information about the field and analytical procedures used by LANL during sample collection and analysis may be found in any HSSR data release prepared by the LANL and will not be included in this report.« less
Cumulative Damage in Strength-Dominated Collisions of Rocky Asteroids: Rubble Piles and Brick Piles

NASA Technical Reports Server (NTRS)

Housen, Kevin

2009-01-01

Laboratory impact experiments were performed to investigate the conditions that produce large-scale damage in rock targets. Aluminum cylinders (6.3 mm diameter) impacted basalt cylinders (69 mm diameter) at speeds ranging from 0.7 to 2.0 km/s. Diagnostics included measurements of the largest fragment mass, velocities of the largest remnant and large fragments ejected from the periphery of the target, and X-ray computed tomography imaging to inspect some of the impacted targets for internal damage. Significant damage to the target occurred when the kinetic energy per unit target mass exceeded roughly 1/4 of the energy required for catastrophic shattering (where the target is reduced to one-half its original mass). Scaling laws based on a rate-dependent strength were developed that provide a basis for extrapolating the results to larger strength-dominated collisions. The threshold specific energy for widespread damage was found to scale with event size in the same manner as that for catastrophic shattering. Therefore, the factor of four difference between the two thresholds observed in the lab also applies to larger collisions. The scaling laws showed that for a sequence of collisions that are similar in that they produce the same ratio of largest fragment mass to original target mass, the fragment velocities decrease with increasing event size. As a result, rocky asteroids a couple hundred meters in diameter should retain their large ejecta fragments in a jumbled rubble-pile state. For somewhat larger bodies, the ejection velocities are sufficiently low that large fragments are essentially retained in place, possibly forming ordered "brick-pile" structures.

Fluid Dynamics in Rotary Piston Blood Pumps.

PubMed

Wappenschmidt, Johannes; Sonntag, Simon J; Buesen, Martin; Gross-Hardt, Sascha; Kaufmann, Tim; Schmitz-Rode, Thomas; Autschbach, Ruediger; Goetzenich, Andreas

2017-03-01

Mechanical circulatory support can maintain a sufficient blood circulation if the native heart is failing. The first implantable devices were displacement pumps with membranes. They were able to provide a sufficient blood flow, yet, were limited because of size and low durability. Rotary pumps have resolved these technical drawbacks, enabled a growing number of mechanical circulatory support therapy and a safer application. However, clinical complications like gastrointestinal bleeding, aortic insufficiency, thromboembolic complications, and impaired renal function are observed with their application. This is traced back to their working principle with attenuated or non-pulsatile flow and high shear stress. Rotary piston pumps potentially merge the benefits of available pump types and seem to avoid their complications. However, a profound assessment and their development requires the knowledge of the flow characteristics. This study aimed at their investigation. A functional model was manufactured and investigated with particle image velocimetry. Furthermore, a fluid-structure interaction computational simulation was established to extend the laboratory capabilities. The numerical results precisely converged with the laboratory measurements. Thus, the in silico model enabled the investigation of relevant areas like gap flows that were hardly feasible with laboratory means. Moreover, an economic method for the investigation of design variations was established.
Laser direct writing of micro- and nano-scale medical devices

PubMed Central

Gittard, Shaun D; Narayan, Roger J

2010-01-01

Laser-based direct writing of materials has undergone significant development in recent years. The ability to modify a variety of materials at small length scales and using short production times provides laser direct writing with unique capabilities for fabrication of medical devices. In many laser-based rapid prototyping methods, microscale and submicroscale structuring of materials is controlled by computer-generated models. Various laser-based direct write methods, including selective laser sintering/melting, laser machining, matrix-assisted pulsed-laser evaporation direct write, stereolithography and two-photon polymerization, are described. Their use in fabrication of microstructured and nanostructured medical devices is discussed. Laser direct writing may be used for processing a wide variety of advanced medical devices, including patient-specific prostheses, drug delivery devices, biosensors, stents and tissue-engineering scaffolds. PMID:20420557
Multiplex Ligation-Dependent Probe Amplification Analysis on Capillary Electrophoresis Instruments for a Rapid Gene Copy Number Study

PubMed Central

Jankowski, Stéphane; Currie-Fraser, Erica; Xu, Licen; Coffa, Jordy

2008-01-01

Annotated DNA samples that had been previously analyzed were tested using multiplex ligation-dependent probe amplification (MLPA) assays containing probes targeting BRCA1, BRCA2, and MMR (MLH1/MSH2 genes) and the 9p21 chromosomal region. MLPA polymerase chain reaction products were separated on a capillary electrophoresis platform, and the data were analyzed using GeneMapper v4.0 software (Applied Biosystems, Foster City, CA). After signal normalization, loci regions that had undergone deletions or duplications were identified using the GeneMapper Report Manager and verified using the DyeScale functionality. The results highlight an easy-to-use, optimal sample preparation and analysis workflow that can be used for both small- and large-scale studies. PMID:19137113
40 CFR 86.1338-84 - Emission measurement accuracy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... engineering practice dictates that exhaust emission sample analyzer readings below 15 percent of full scale... computers, data loggers, etc., can provide sufficient accuracy and resolution below 15 percent of full scale... spaced points, using good engineering judgement, below 15 percent of full scale are made to ensure the...
40 CFR 86.1338-84 - Emission measurement accuracy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... engineering practice dictates that exhaust emission sample analyzer readings below 15 percent of full scale... computers, data loggers, etc., can provide sufficient accuracy and resolution below 15 percent of full scale... spaced points, using good engineering judgement, below 15 percent of full scale are made to ensure the...
40 CFR 86.1338-84 - Emission measurement accuracy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... engineering practice dictates that exhaust emission sample analyzer readings below 15 percent of full scale... computers, data loggers, etc., can provide sufficient accuracy and resolution below 15 percent of full scale... spaced points, using good engineering judgement, below 15 percent of full scale are made to ensure the...
40 CFR 86.1338-84 - Emission measurement accuracy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... engineering practice dictates that exhaust emission sample analyzer readings below 15 percent of full scale... computers, data loggers, etc., can provide sufficient accuracy and resolution below 15 percent of full scale... spaced points, using good engineering judgement, below 15 percent of full scale are made to ensure the...
Using Magnitude Estimation Scaling in Business Communication Research.

ERIC Educational Resources Information Center

Sturges, David L.

1990-01-01

Critically analyzes magnitude estimation scaling for its potential use in business communication research. Finds that the 12-15 percent increase in explained variance by magnitude estimation over categorical scaling methods may be useful in theory building but may not be sufficient to justify its added expense in applied business communication…
University of Wisconsin Ion Beam Laboratory: A facility for irradiated materials and ion beam analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, K. G.; Wetteland, C. J.; Cao, G.

2013-04-19

The University of Wisconsin Ion Beam Laboratory (UW-IBL) has recently undergone significant infrastructure upgrades to facilitate graduate level research in irradiated materials phenomena and ion beam analysis. A National Electrostatics Corp. (NEC) Torodial Volume Ion Source (TORVIS), the keystone upgrade for the facility, can produce currents of hydrogen ions and helium ions up to {approx}200 {mu}A and {approx}5 {mu}A, respectively. Recent upgrades also include RBS analysis packages, end station developments for irradiation of relevant material systems, and the development of an in-house touch screen based graphical user interface for ion beam monitoring. Key research facilitated by these upgrades includes irradiationmore » of nuclear fuels, studies of interfacial phenomena under irradiation, and clustering dynamics of irradiated oxide dispersion strengthened steels. The UW-IBL has also partnered with the Advanced Test Reactor National Scientific User Facility (ATR-NSUF) to provide access to the irradiation facilities housed at the UW-IBL as well as access to post irradiation facilities housed at the UW Characterization Laboratory for Irradiated Materials (CLIM) and other ATR-NSUF partner facilities. Partnering allows for rapid turnaround from proposed research to finalized results through the ATR-NSUF rapid turnaround proposal system. An overview of the UW-IBL including CLIM and relevant research is summarized.« less
Application of lab derived kinetic biodegradation parameters at the field scale

NASA Astrophysics Data System (ADS)

Schirmer, M.; Barker, J. F.; Butler, B. J.; Frind, E. O.

2003-04-01

Estimating the intrinsic remediation potential of an aquifer typically requires the accurate assessment of the biodegradation kinetics, the level of available electron acceptors and the flow field. Zero- and first-order degradation rates derived at the laboratory scale generally overpredict the rate of biodegradation when applied to the field scale, because limited electron acceptor availability and microbial growth are typically not considered. On the other hand, field estimated zero- and first-order rates are often not suitable to forecast plume development because they may be an oversimplification of the processes at the field scale and ignore several key processes, phenomena and characteristics of the aquifer. This study uses the numerical model BIO3D to link the laboratory and field scale by applying laboratory derived Monod kinetic degradation parameters to simulate a dissolved gasoline field experiment at Canadian Forces Base (CFB) Borden. All additional input parameters were derived from laboratory and field measurements or taken from the literature. The simulated results match the experimental results reasonably well without having to calibrate the model. An extensive sensitivity analysis was performed to estimate the influence of the most uncertain input parameters and to define the key controlling factors at the field scale. It is shown that the most uncertain input parameters have only a minor influence on the simulation results. Furthermore it is shown that the flow field, the amount of electron acceptor (oxygen) available and the Monod kinetic parameters have a significant influence on the simulated results. Under the field conditions modelled and the assumptions made for the simulations, it can be concluded that laboratory derived Monod kinetic parameters can adequately describe field scale degradation processes, if all controlling factors are incorporated in the field scale modelling that are not necessarily observed at the lab scale. In this way, there are no scale relationships to be found that link the laboratory and the field scale, accurately incorporating the additional processes, phenomena and characteristics, such as a) advective and dispersive transport of one or more contaminants, b) advective and dispersive transport and availability of electron acceptors, c) mass transfer limitations and d) spatial heterogeneities, at the larger scale and applying well defined lab scale parameters should accurately describe field scale processes.
Historical Special Topic Overview on Rabbit Comparative Biology Biology of the Rabbit

PubMed Central

Brewer, Nathan R.

2006-01-01

Editor’s note: In recognition of Dr. Nathan Brewer’s many years of dedicated service to AALAS and the community of research animal care specialists, the premier issue of JAALAS includes the following compilation of Dr. Brewer’s essays on rabbit anatomy and physiology. These essays were originally published in the ASLAP newsletter (formerly called Synapse), and are reprinted here with the permission and endorsement of that organization. I would like to thank Nina Hahn, Jane Lacher, and Nancy Austin for assistance in compiling these essays. Publishing this information in JAALAS allows Dr. Brewer’s work to become part of the searchable literature for laboratory animal science and medicine and also assures that the literature references and information he compiled will not be lost to posterity. However, readers should note that this material has undergone only minor editing for style, has not been edited for content, and, most importantly, has not undergone peer review. With the agreement of the associate editors and the AALAS leadership, I elected to forego peer review of this work, in contradiction to standard JAALAS policy, based on the status of this material as pre-published information from an affiliate organization that holds the copyright and on the esteem in which we hold for Dr. Brewer as a founding father of our organization. –Linda A. Toth, Editor in Chief, AALAS Journals PMID:16539330
Sexual risk behaviors and psychosocial health concerns of female-to-male transgender men screening for STDs at an urban community health center

PubMed Central

Reisner, Sari L.; White, Jaclyn M.; Mayer, Kenneth H.; Mimiaga, Matthew J.

2015-01-01

The sexual health of female-to-male (FTM) transgender men remains understudied. De-identified electronic medical records of 23 FTMs (mean age = 32, 48% racial/ethnic minority) who screened for sexually transmitted diseases (STDs) between July and December 2007 at a Boston, Massachusetts area health center were analyzed. Almost half (48%) were on testosterone and 39% had undergone chest surgery; none had undergone genital reconstruction. The majority (57%) were bisexual, and 30% reported sex with nontransgender males only in the prior three months. One individual was HIV-infected (4.3%) and two (8.7%) had a history of STDs (all laboratory-confirmed). Overall, 26% engaged in sexual risk behavior in the prior three months (i.e., unprotected sex with a nontransgender male, condom breakage, or anonymous sex). The majority (61%) had a DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) diagnosis (52% depression, 52% anxiety, and 26% adjustment disorder), and regular alcohol use was common (65%). Alcohol use, psychosocial distress histories, and sex with males only (versus with males and females) were associated with sexual risk in the past three months. Transgender men have concomitant psychosocial health vulnerabilities which may contribute to sexual risk behaviors. Future research is needed to understand the myriad social, behavioral, and biological factors that contribute to HIV and STD vulnerability for FTMs. PMID:24206043
The innovative osmotic membrane bioreactor (OMBR) for reuse of wastewater.

PubMed

Cornelissen, E R; Harmsen, D; Beerendonk, E F; Qin, J J; Oo, H; de Korte, K F; Kappelhof, J W M N

2011-01-01

An innovative osmotic membrane bioreactor (OMBR) is currently under development for the reclamation of wastewater, which combines activated sludge treatment and forward osmosis (FO) membrane separation with a RO post-treatment. The research focus is FO membrane fouling and performance using different activated sludge investigated both at laboratory scale (membrane area of 112cm2) and at on-site bench scale (flat sheet membrane area of 0.1 m2). FO performance on laboratory-scale (i) increased with temperature due to a decrease in viscosity and (ii) was independent of the type of activated sludge. Draw solution leakage increased with temperature and varied for different activated sludge. FO performance on bench-scale (i) increased with osmotic driving force, (ii) depended on the membrane orientation due to internal concentration polarization and (iii) was invariant to feed flow decrease and air injection at the feed and draw side. Draw solution leakage could not be evaluated on bench-scale due to experimental limitation. Membrane fouling was not found on laboratory scale and bench-scale, however, partially reversible fouling was found on laboratory scale for FO membranes facing the draw solution. Economic assessment indicated a minimum flux of 15L.m-2 h-1 at 0.5M NaCl for OMBR-RO to be cost effective, depending on the FO membrane price.
Design and development of a solar powered mobile laboratory

NASA Astrophysics Data System (ADS)

Jiao, L.; Simon, A.; Barrera, H.; Acharya, V.; Repke, W.

2016-08-01

This paper describes the design and development of a solar powered mobile laboratory (SPML) system. The SPML provides a mobile platform that schools, universities, and communities can use to give students and staff access to laboratory environments where dedicated laboratories are not available. The lab includes equipment like 3D printers, computers, and soldering stations. The primary power source of the system is solar PV which allows the laboratory to be operated in places where the grid power is not readily available or not sufficient to power all the equipment. The main system components include PV panels, junction box, battery, charge controller, and inverter. Not only is it used to teach students and staff how to use the lab equipment, but it is also a great tool to educate the public about solar PV technologies.
FIELD AND LABORATORY EVALUATION OF DNAPL REMEDIAL PERFORMANCE

EPA Science Inventory

The basic goal of DNAPL source treatment is to reduce health and environmental risks posed by the DNAPL contamination. Removing a sufficient mass of DNAPL to achieve concentration-based regulatory goals is difficult because of site hydrogeologic heterogeneity and uncertainties ab...
Chiari malformation and central sleep apnea syndrome: efficacy of treatment with adaptive servo-ventilation*

PubMed Central

do Vale, Jorge Marques; Silva, Eloísa; Pereira, Isabel Gil; Marques, Catarina; Sanchez-Serrano, Amparo; Torres, António Simões

2014-01-01

The Chiari malformation type I (CM-I) has been associated with sleep-disordered breathing, especially central sleep apnea syndrome. We report the case of a 44-year-old female with CM-I who was referred to our sleep laboratory for suspected sleep apnea. The patient had undergone decompressive surgery 3 years prior. An arterial blood gas analysis showed hypercapnia. Polysomnography showed a respiratory disturbance index of 108 events/h, and all were central apnea events. Treatment with adaptive servo-ventilation was initiated, and central apnea was resolved. This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery. PMID:25410846
Next-generation avionics packaging and cooling 'test results from a prototype system'

NASA Astrophysics Data System (ADS)

Seals, J. D.

The author reports on the design, material characteristics, and test results obtained under the US Air Force's advanced aircraft avionics packaging technologies (AAAPT) program, whose charter is to investigate new designs and technologies for reliable packaging, interconnection, and thermal management. Under this program, AT&T Bell Laboratories has completed the preliminary testing of and is evaluating a number of promising materials and technologies, including conformal encapsulation, liquid flow-through cooling, and a cyanate ester backplane. A fifty-two module system incorporating these and and other technologies has undergone preliminary cooling efficiency, shock, sine and random vibration, and maintenance testing. One of the primary objectives was to evaluate the interaction compatibility of new materials and designs with other components in the system.
PAH in the laboratory and interstellar space

NASA Technical Reports Server (NTRS)

Wdowiak, Thomas J.; Flickinger, Gregory C.; Boyd, David A.

1989-01-01

The theory that polycyclic aromatic hydrocarbons (PAHs) are a constituent of the interstellar medium, and a source of the IR emission bands at 3.3, 6.2, 7.7, 8.6, and 11.3 microns is being studied using PAH containing acid insoluble residue of the Orgueil CI meteorite and coal tar. FTIR spectra of Orgueil PAH material that has undergone thermal treatment, and a solvent insoluble fraction of coal tar that has been exposed to hydrogen plasma are presented. The UV excided luminescence spectrum of a solvent soluble coal tar film is also shown. Comparison of the lab measurements with observations appears to support the interstellar PAH theory, and shows the process of dehydrogenation expected to take place in the interstellar medium.
The Cold War is Over. What Now?

DOE R&D Accomplishments Database

Hecker, S. S.

1995-04-01

As you might imagine, the end of the Cold War has elicited an intense reexamination of the roles and missions of institutions such as the Los Alamos National Laboratory. During the past few years, the entire defense establishment has undergone substantial consolidation, with a concomitant decrease in support for research and development, including in areas such as materials. The defense industry is down-sizing at a rapid pace. Even universities have experienced significant funding cutbacks from the defense community. I view this as a profound time in history, bringing changes encompassing much more than just the defense world. In fact, support for science and technology is being reexamined across the board more completely than at any other time since the end of World War II.
[Quality of 3D magnetic resonance imaging of coronary arteries in patients with D-transposition of the great arteries after the Jatene switch procedure].

PubMed

Marín Rodríguez, C; Lancharro Zapata, Á; Rodríguez Ogando, A; Carrasco Muñoz, S; Ruiz Martín, Y; Sánchez Alegre, M L; Maroto Alvaro, E

2015-01-01

To evaluate the quality of images obtained with 3D balanced fast-field echo whole heart (WH3D) MRI sequences for assessing the coronary anastomosis and coronary stenosis in patients with D-transposition of the great arteries who have undergone the Jatene switch procedure. We retrieved 100 WH3D studies done in 83 patients who had undergone the Jatene switch procedure from our pediatric cardiac MRI database; 84 of these studies fulfilled the criteria for inclusion in the study. We evaluated coronary stenoses on WH3D MR images and their correlation with coronary CT or angiography images. We retrospectively studied the quality of the images of the proximal coronary arteries using a four-point scale and correlating the findings with age, heart rate, and heart size. Of the 84 studies, 4 (4.8%) were of a quality considered «insufficient for diagnosis», 7 (8.3%) were considered «fair», 23 (27.4%) «good», and 50 (59.5%) «excellent». The quality of the image of the coronary arteries was significantly correlated with heart rate. MRI detected stenosis in the origin of the coronary arteries in 9 (10.7%) studies. Images obtained with the WH3D MRI sequence in patients who had undergone the Jatene procedure were of diagnostic quality in most cases and were better in patients with lower heart rates. In 10.7%, stenosis in the origin of the coronary arteries that required new studies was detected. Copyright © 2014 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

Influence of body mass index on the outcome of brachial plexus surgery: are there any differences between elbow and shoulder results?

PubMed

Socolovsky, Mariano; Martins, Roberto S; Di Masi, Gilda; Bonilla, Gonzalo; Siqueira, Mario G

2014-12-01

Body mass index (BMI) has recently been identified as a predictor of outcomes following reconstructive surgery of shoulder palsies. In this study, we sought to determine if the same holds true for the reconstruction of elbow flexion. Forty patients who had undergone partial ulnar-to-biceps nerve transfer (Oberlin's procedure) for shoulder palsy were assessed and compared against 18 previously reported patients who had undergone reconstruction for elbow palsies. The British Medical Research Council (BMRC) scale and an index dividing shoulder abduction strength in the affected arm by healthy arm were recorded. All patients had undergone surgery within 12 months of injury and had ≥ 12 months of follow-up. M4 or M3 biceps strength was obtained in 90 % of patients. Final strength on the affected side averaged 5.8 kg, versus 20.2 kg on the normal side, for a mean recovery index score of 0.30. In this sample of 40 patients, BMI did not predict percentage strength or BMRC grade recovery. Neither did age, number of roots involved, the affected side, nor time to surgery. Comparing patients with elbow versus shoulder reconstruction, there were no differences, except that patients undergoing Oberlin's procedure had a statistically longer duration of time between injury and surgical repair (7.4 vs 5.1 months, p < 0.006). Our data suggest that proximal muscle re-innervation is functionally more dependent upon BMI than distal re-innervation, likely because proximal muscles must support the weight of the entire extremity, while more distal muscles do not. BMI should be taken into consideration when planning surgery.
A comparison of weather variables linked to infectious disease patterns using laboratory addresses and patient residence addresses.

PubMed

Djennad, Abdelmajid; Lo Iacono, Giovanni; Sarran, Christophe; Fleming, Lora E; Kessel, Anthony; Haines, Andy; Nichols, Gordon L

2018-04-27

To understand the impact of weather on infectious diseases, information on weather parameters at patient locations is needed, but this is not always accessible due to confidentiality or data availability. Weather parameters at nearby locations are often used as a proxy, but the accuracy of this practice is not known. Daily Campylobacter and Cryptosporidium cases across England and Wales were linked to local temperature and rainfall at the residence postcodes of the patients and at the corresponding postcodes of the laboratory where the patient's specimen was tested. The paired values of daily rainfall and temperature for the laboratory versus residence postcodes were interpolated from weather station data, and the results were analysed for agreement using linear regression. We also assessed potential dependency of the findings on the relative geographic distance between the patient's residence and the laboratory. There was significant and strong agreement between the daily values of rainfall and temperature at diagnostic laboratories with the values at the patient residence postcodes for samples containing the pathogens Campylobacter or Cryptosporidium. For rainfall, the R-squared was 0.96 for the former and 0.97 for the latter, and for maximum daily temperature, the R-squared was 0.99 for both. The overall mean distance between the patient residence and the laboratory was 11.9 km; however, the distribution of these distances exhibited a heavy tail, with some rare situations where the distance between the patient residence and the laboratory was larger than 500 km. These large distances impact the distributions of the weather variable discrepancies (i.e. the differences between weather parameters estimated at patient residence postcodes and those at laboratory postcodes), with discrepancies up to ±10 °C for the minimum and maximum temperature and 20 mm for rainfall. Nevertheless, the distributions of discrepancies (estimated separately for minimum and maximum temperature and rainfall), based on the cases where the distance between the patient residence and the laboratory was within 20 km, still exhibited tails somewhat longer than the corresponding exponential fits suggesting modest small scale variations in temperature and rainfall. The findings confirm that, for the purposes of studying the relationships between meteorological variables and infectious diseases using data based on laboratory postcodes, the weather results are sufficiently similar to justify the use of laboratory postcode as a surrogate for domestic postcode. Exclusion of the small percentage of cases where there is a large distance between the residence and the laboratory could increase the precision of estimates, but there are generally strong associations between daily weather parameters at residence and laboratory.
Combining Monitoring Data Spanning Multiple Temporal and Spatial Scales To Evaluate Water Quality Affecting Seagrass Habitat Extent in northwest Florida Estuaries

EPA Science Inventory

The ability to understand and manage ecological changes caused by anthropogenic stressors is often impeded by a lack of sufficient information to resolve pattern and change with sufficient resolution and extent. Increasingly, different types of environmental data are available t...
Investigation of Professional Self Sufficiency Levels of Physical Education and Sports Teachers

ERIC Educational Resources Information Center

Saracaoglu, Asuman Seda; Ozsaker, Murat; Varol, Rana

2012-01-01

The present research aimed at detecting professional self sufficiency levels of physical education and sports teachers who worked in Izmir Province and at investigating them in terms of some variables. For data collection, Teacher's Sense of Efficacy Scale-developed by Moran and Woolfolk-Hoy (2001) and Turkish validity and reliability studies…
Definition of experiments and instruments for a communication/navigation research laboratory. Volume 2: Experiment selection

NASA Technical Reports Server (NTRS)

1972-01-01

The selection and definition of candidate experiments and the associated experiment instrumentation requirements are described. Information is presented that addresses the following study objectives: (1) determine specific research and technology needs in the comm/nav field through a survey of the scientific/technical community; (2) develop manned low earth orbit space screening criteria and compile lists of potential candidate experiments; (3) in Blue Book format, define and describe selected candidate experiments in sufficient detail to develop laboratory configuration designs and layouts; and (4) develop experiment time phasing criteria and recommend a payload for sortie can/early laboratory missions.
LABORATORY SCALE STEAM INJECTION TREATABILITY STUDIES

EPA Science Inventory

Laboratory scale steam injection treatability studies were first developed at The University of California-Berkeley. A comparable testing facility has been developed at USEPA's Robert S. Kerr Environmental Research Center. Experience has already shown that many volatile organic...
One-step fabrication of multifunctional micromotors

NASA Astrophysics Data System (ADS)

Gao, Wenlong; Liu, Mei; Liu, Limei; Zhang, Hui; Dong, Bin; Li, Christopher Y.

2015-08-01

Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications.Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications. Electronic supplementary information (ESI) available: Videos S1-S4 and Fig. S1-S3. See DOI: 10.1039/c5nr03574k
The effects of whole-vault cranioplasty versus strip craniectomy on long-term neuropsychological outcomes in sagittal craniosynostosis.

PubMed

Hashim, Peter W; Patel, Anup; Yang, Jenny F; Travieso, Roberto; Terner, Jordan; Losee, Joseph E; Pollack, Ian; Jane, John; Jane, John; Kanev, Paul; Mayes, Linda; Duncan, Charles; Bridgett, David J; Persing, John A

2014-09-01

The optimal type of surgical management for isolated sagittal synostosis remains a source of significant debate. There is a paucity of data regarding possible differences in long-term neuropsychological outcomes following treatment with whole-vault cranioplasty or endoscopic strip craniectomy. This study provides the first comparative analysis examining the effects of the two techniques related to long-term intellectual functioning. A total of 70 patients were enrolled in this multicenter study, 29 of whom had previously undergone endoscopic strip craniectomy and 41 of whom had previously undergone whole-vault cranioplasty. All patients completed a battery of neurodevelopmental tests (Beery-Buktenica Developmental Test of Visual-Motor Integration, Wechsler Abbreviated Scale of Intelligence, and Wechsler Fundamentals) to evaluate various domains of neuropsychological function. In a group comparison of those treated before 6 months of age, whole-vault patients obtained higher scores relative to endoscopic strip craniectomy patients on visuomotor integration, full-scale intelligence quotient, verbal intelligence quotient, word reading, and reading comprehension (p < 0.05 for all). When compared against strip craniectomy performed before 3 months of age, the whole-vault group still showed significantly higher scores in verbal intelligence quotient, reading comprehension, and word reading (p < 0.05 for all). The type of surgical intervention for isolated sagittal synostosis impacts long-term neuropsychological outcomes. Patients undergoing early whole-vault cranioplasty attained higher intelligence quotient and achievement scores relative to those undergoing strip craniectomy. Surgical management with whole-vault cranioplasty performed before 6 months of age provides the most favorable long-term intellectual outcomes in patients with isolated sagittal synostosis. Therapeutic, II.
Blood transfusion and risk of atrial fibrillation after coronary artery bypass graft surgery

PubMed Central

Liu, Shengqun; Li, Zhanwen; Liu, Zhe; Hu, Zhenhua; Zheng, Gaifang

2018-01-01

Abstract The aim of this study was to systematically evaluate the effect of blood transfusion (BT) on postoperative atrial fibrillation (AF) in adult patients who had undergone coronary artery bypass grafting (CABG) surgery. PubMed, Embase, and Cochrane Library databases from inception to January 2017 were searched. Cohort studies were searched that evaluated the association between BT and the risk of postoperative AF in adult patients who had undergone CABG surgery. Study quality was assessed by using the Newcastle–Ottawa scale (NOS). A meta-analysis was performed with the random-effect model. Eight cohort studies involving 7401 AF cases and 31,069 participants were identified and included in our data analysis. The pooled odds ratio of postoperative AF in patients with BT was 1.45 (95% confidence interval, 1.26–1.67), with significant heterogeneity (P < .0001, I2 = 79%). Excluding one study that had an off-pump CABG did not significantly impact this result (odds ratio, 1.36; 95% confidence interval, 1.23–1.50; n = 7). To examine the stability of the primary results, we performed subgroup analyses. The association between BT and the risk of postoperative AF was similar, as determined in the stratified analyses conducted according to study design, type of surgery, and country. The findings of the present meta-analysis demonstrated a statistically significant increase in postoperative AF risk among adult patients with BT. Further prospective large-scale studies are needed to establish causality and to elucidate the underlying mechanisms. PMID:29517692
Validation of laboratory-scale recycling test method of paper PSA label products

Treesearch

Carl Houtman; Karen Scallon; Richard Oldack

2008-01-01

Starting with test methods and a specification developed by the U.S. Postal Service (USPS) Environmentally Benign Pressure Sensitive Adhesive Postage Stamp Program, a laboratory-scale test method and a specification were developed and validated for pressure-sensitive adhesive labels, By comparing results from this new test method and pilot-scale tests, which have been...
DOE Office of Scientific and Technical Information (OSTI.GOV)

Shull, H.E.

The objective of the project was to investigate the economic feasibility of converting potato waste to fuel alcohol. The source of potato starch was Troyer Farms Potato Chips. Experimental work was carried out at both the laboratory scale and the larger pilot scale batch operation at a decommissioned waste water treatment building on campus. The laboratory scale work was considerably more extensive than originally planned, resulting in a much improved scientific work. The pilot scale facility has been completed and operated successfully. In contrast, the analysis of the economic feasibility of commercial production has not yet been completed. The projectmore » was brought to a close with the successful demonstration of the fermentation and distillation using the large scale facilities described previously. Two batches of mash were cooked using the procedures established in support of the laboratory scale work. One of the batches was fermented using the optimum values of the seven controlled factors as predicted by the laboratory scale application of the Box-Wilson design. The other batch was fermented under conditions derived out of Mr. Rouse's interpretation of his long sequence of laboratory results. He was gratified to find that his commitment to the Box-Wilson experiments was justified. The productivity of the Box-Wilson design was greater. The difference between the performance of the two fermentors (one stirred, one not) has not been established yet. Both batches were then distilled together, demonstrating the satisfactory performance of the column still. 4 references.« less
Dynamic restraint capacity of the hamstring muscles has important functional implications after anterior cruciate ligament injury and anterior cruciate ligament reconstruction.

PubMed

Bryant, Adam L; Creaby, Mark W; Newton, Robert U; Steele, Julie R

2008-12-01

The purpose of this study was to investigate the relation between knee functionality of anterior cruciate ligament deficient (ACLD) and anterior cruciate ligament reconstruction (ACLR) patients and hamstring antagonist torque generated during resisted knee extension. Cross-sectional. Laboratory based. Male ACLD subjects (n=10) (18-35 y) and 27 matched males who had undergone ACLR (14 patella tendon [PT] grafts and 13 combined semitendinosus/gracilis tendon grafts). Not applicable. Knee functionality was rated (0- to 100-point scale) by using the Cincinnati Knee Rating System. Using electromyography data from the semitendinosus (ST) and biceps femoris muscles, we created a mathematical model to estimate the opposing torque generated by the hamstrings during isokinetic knee extension in 10 degrees intervals from 80 degrees to 10 degrees knee flexion. Pearson product-moment correlations revealed that more functional ACLD subjects generated significantly (P<.05) higher hamstring antagonist torque throughout knee extension. In contrast, more functional PT subjects produced significantly lower hamstring antagonist torque at 80 degrees to 70 degrees knee flexion, whereas no significant associations were found between hamstring antagonist torque and knee functionality for the ST/gracilis tendon subjects. An increased hamstring antagonist torque generated by the more functional ACLD subjects, reflective of increased hamstring contractile force, is thought to represent a protective mechanism to compensate for mechanical instability. The restoration of anterior knee stability through ACLR negates the need for augmented hamstring antagonist torque.
Hydrodynamic dispersion of microswimmers in suspension

NASA Astrophysics Data System (ADS)

Martin, Matthieu; Rafaï, Salima; Peyla, Philippe

2014-11-01

In our laboratory, we study hydrodynamics of suspensions of micro-swimmers. These micro-organisms are unicellular algae Chlamydomonas Rheinhardii which are able to swim by using their flagella. The swimming dynamics of these micro-swimmers can be seen as a random walk, in absence of any kind of interaction. In addition, these algae have the property of being phototactic, i.e. they swim towards the light. Combining this property with a hydrodynamic flow, we were able to reversibly separate algae from the rest of the fluid. But for sufficiently high volume fraction, these active particles interact with each other. We are now interested in how the coupling of hydrodynamic interactions between swimmers and phototaxis can modify the swimming dynamics at the scale of the suspension. To this aim, we conduct experiments in microfluidic devices to study the dispersion of the micro-organisms in a the liquid phase as a function of the volume fraction. We show that the dispersion of an assembly of puller type microswimmers is quantitatively affected by hydrodynamics interactions. Phd student.
A haptic-inspired audio approach for structural health monitoring decision-making

NASA Astrophysics Data System (ADS)

Mao, Zhu; Todd, Michael; Mascareñas, David

2015-03-01

Haptics is the field at the interface of human touch (tactile sensation) and classification, whereby tactile feedback is used to train and inform a decision-making process. In structural health monitoring (SHM) applications, haptic devices have been introduced and applied in a simplified laboratory scale scenario, in which nonlinearity, representing the presence of damage, was encoded into a vibratory manual interface. In this paper, the "spirit" of haptics is adopted, but here ultrasonic guided wave scattering information is transformed into audio (rather than tactile) range signals. After sufficient training, the structural damage condition, including occurrence and location, can be identified through the encoded audio waveforms. Different algorithms are employed in this paper to generate the transformed audio signals and the performance of each encoding algorithms is compared, and also compared with standard machine learning classifiers. In the long run, the haptic decision-making is aiming to detect and classify structural damages in a more rigorous environment, and approaching a baseline-free fashion with embedded temperature compensation.
A simple autocorrelation algorithm for determining grain size from digital images of sediment

USGS Publications Warehouse

Rubin, D.M.

2004-01-01

Autocorrelation between pixels in digital images of sediment can be used to measure average grain size of sediment on the bed, grain-size distribution of bed sediment, and vertical profiles in grain size in a cross-sectional image through a bed. The technique is less sensitive than traditional laboratory analyses to tails of a grain-size distribution, but it offers substantial other advantages: it is 100 times as fast; it is ideal for sampling surficial sediment (the part that interacts with a flow); it can determine vertical profiles in grain size on a scale finer than can be sampled physically; and it can be used in the field to provide almost real-time grain-size analysis. The technique can be applied to digital images obtained using any source with sufficient resolution, including digital cameras, digital video, or underwater digital microscopes (for real-time grain-size mapping of the bed). ?? 2004, SEPM (Society for Sedimentary Geology).
N,N-dimethylsulfamide as precursor for N-nitrosodimethylamine (NDMA) formation upon ozonation and its fate during drinking water treatment.

PubMed

Schmidt, Carsten K; Brauch, Heinz-Jürgen

2008-09-01

Application and microbial degradation of the fungicide tolylfluanide gives rise to a new decomposition product named N,N-dimethylsulfamide (DMS). In Germany, DMS was found in groundwaters and surface waters with typical concentrations in the range of 100-1000 ng/L and 50-90 ng/L, respectively. Laboratory-scale and field investigations concerning its fate during drinking water treatment showed that DMS cannot be removed via riverbank filtration, activated carbon filtration, flocculation, and oxidation or disinfection procedures based on hydrogen peroxide, potassium permanganate, chlorine dioxide, or UV irradiation. Even nanofiltration does not provide a sufficient removal efficiency. During ozonation about 30-50% of DMS are converted to the carcinogenic N-nitrosodimethylamine (NDMA). The NDMA being formed is biodegradable and can at least partially be removed by subsequent biologically active drinking water treatment steps including sand or activated carbon filtration. Disinfection with hypochlorous acid converts DMS to so far unknown degradation products but not to NDMA or 1,1-dimethylhydrazine (UDMH).
Is the gas-particle partitioning in alpha-pinene secondary organic aerosol reversible?

NASA Astrophysics Data System (ADS)

Grieshop, Andrew P.; Donahue, Neil M.; Robinson, Allen L.

2007-07-01

This paper discusses the reversibility of gas-particle partitioning in secondary organic aerosol (SOA) formed from α-pinene ozonolysis in a smog chamber. Previously, phase partitioning has been studied quantitatively via SOA production experiments and qualitatively by perturbing temperature and observing particle evaporation. In this work, two methods were used to isothermally dilute the SOA: an external dilution sampler and an in-chamber technique. Dilution caused some evaporation of SOA, but repartitioning took place on a time scale of tens of minutes to hours-consistent with an uptake coefficient on the order of 0.001-0.01. However, given sufficient time, α-pinene SOA repartitions reversibly based on comparisons with data from conventional SOA yield experiments. Further, aerosol mass spectrometer (AMS) data indicate that the composition of SOA varies with partitioning. These results suggest that oligomerization observed in high-concentration laboratory experiments may be a reversible process and underscore the complexity of the kinetics of formation and evaporation of SOA.
A proposed intense slow positron source based on 58Co

NASA Astrophysics Data System (ADS)

Brown, Benjamin L.; Denison, Art; Makowitz, Henry; Gidley, Dave; Frieze, Bill; Griffin, Henry; Encarnación, Pedro

1994-06-01

Positron beams have proven very useful for condensed matter and surface research. The highest intensity of the current operating positron beams is ˜109 slow e+/second. The goal of our proposal is to build an Intense Slow Positron Source (ISPS) demonstration beam (Phase I) of unprecedented brightness at the Idaho National Engineering Laboratory, INEL (up to 1010 slow e+/s at 5 keV over a <0.03 cm. diameter). This Phase I beam will prove the principles necessary to build a larger facility scale ISPS Phase II beam which will have a potential of 1013 e+/s, or ≳1012 e+/s over 0.03 cm. The INEL is an ideal location for the ISPS because of the fast breeder reactor EBR-II, which is perfectly suited to creating the positron emitting isotope 58Co, and the excellent radioactive materials handling capability and expertise. Sufficient expertise is available at INEL for the construction and operation of a user facility (Phase II).
Emotion in Painting and Art Installations.

PubMed

Konečni, Vladimir J

2015-01-01

Paintings are static 2-dimensional images with limited narrative means. On the basis of a critical analysis of the relevant laboratory scaling studies, museum studies, and neuroaesthetic work, the article reaches a negative conclusion about most paintings' ability to engage sufficiently with general viewers' associative-memory systems, so as to lead to identification and empathy, and induce fundamental psychobiological emotions. In contrast, designers of art installations can draw on subtle combinations of several classes of stimulus properties with psychological significance subsumable under the classical concept of the sublime (physical grandeur, rarity, an association with beauty and with biologically significant outcomes), so that some installations may induce the peak aesthetic emotional response, aesthetic awe--as defined in Aesthetic Trinity Theory (Konečni, 2005, 2011), along with the states of being moved and physiological thrills. The approach also involves an analytical skepticism about emotivism, defined as a culturological proclivity for unnecessary insertion of emotion into accounts of mental life and behavior, especially in the arts. Implications for the role of emotion theory in empirical aesthetics are examined.
Development of the electric vehicle analyzer

NASA Astrophysics Data System (ADS)

Dickey, Michael R.; Klucz, Raymond S.; Ennix, Kimberly A.; Matuszak, Leo M.

1990-06-01

The increasing technological maturity of high power (greater than 20 kW) electric propulsion devices has led to renewed interest in their use as a means of efficiently transferring payloads between earth orbits. Several systems and architecture studies have identified the potential cost benefits of high performance Electric Orbital Transfer Vehicles (EOTVs). These studies led to the initiation of the Electric Insertion Transfer Experiment (ELITE) in 1988. Managed by the Astronautics Laboratory, ELITE is a flight experiment designed to sufficiently demonstrate key technologies and options to pave the way for the full-scale development of an operational EOTV. An important consideration in the development of the ELITE program is the capability of available analytical tools to simulate the orbital mechanics of a low thrust, electric propulsion transfer vehicle. These tools are necessary not only for ELITE mission planning exercises but also for continued, efficient, accurate evaluation of DoD space transportation architectures which include EOTVs. This paper presents such a tool: the Electric Vehicle Analyzer (EVA).

The development and stability of non-thermal plasma in space

NASA Astrophysics Data System (ADS)

Kasper, Justin

2017-10-01

This talk will review our understanding of non-thermal ion and electron velocity distribution functions (VDFs) in space plasma, with a focus on pressure anisotropy and unequal temperatures in the solar wind and corona. Under typical solar wind plasma conditions, which are common for a range of astrophysical plasmas, relaxation processes such as Coulomb collisions are sufficiently slow compared to interactions between particles and electromagnetic fluctuations that ion and electron VDFs can depart significantly from the classical Maxwell-Boltzmann distribution and maintain these non-thermal features for times greater than the dynamical scales of the system. These non-thermal properties of the plasma are very important as they can significantly modify aspects of the plasma such as heat flux, susceptibility to kinetic instabilities, and interaction with waves and turbulence. Major open questions in the field will be reviewed, along with current and planned observational capabilities of instruments on spacecraft such as Wind and the upcoming Parker Solar Probe, with an eye to potential crossover with laboratory plasma experiments.
Computational technique and performance of Transient Inundation Model for Rivers--2 Dimensional (TRIM2RD) : a depth-averaged two-dimensional flow model

USGS Publications Warehouse

Fulford, Janice M.

2003-01-01

A numerical computer model, Transient Inundation Model for Rivers -- 2 Dimensional (TrimR2D), that solves the two-dimensional depth-averaged flow equations is documented and discussed. The model uses a semi-implicit, semi-Lagrangian finite-difference method. It is a variant of the Trim model and has been used successfully in estuarine environments such as San Francisco Bay. The abilities of the model are documented for three scenarios: uniform depth flows, laboratory dam-break flows, and large-scale riverine flows. The model can start computations from a ?dry? bed and converge to accurate solutions. Inflows are expressed as source terms, which limits the use of the model to sufficiently long reaches where the flow reaches equilibrium with the channel. The data sets used by the investigation demonstrate that the model accurately propagates flood waves through long river reaches and simulates dam breaks with abrupt water-surface changes.
Conference scene: Summary of the 6th Conference of the Romanian Association of Medical Laboratories with international participation.

PubMed

Carasevici, Eugen

2011-10-01

The Romanian Association of Medical Laboratories (RAML) conferences have acquired a reputation for standing out as the most prominent and efficient meetings in the national community of laboratory medicine, being a landmark of the development in this field in Romania and an active affiliation to international forums. This year, the conference setting was Piatra Neamt, in the northeast part of Romania, which produced a friendly and stimulating professional environment. As in previous years, leading experts in the fields of laboratory medicine attended the event. This year, we enjoyed the opportunity to have such distinguished guests as the members of the executive board of International Federation of Clinical Chemistry and Laboratory Medicine (IFCC); Graham Beastall, IFCC President; Päivi Hannele Laitinen, IFCC secretary; and Grazyna Sypniewska, IFCC Communication and Publication Division, and editor of the electronic journal of the IFCC. As usual, the conference program included all aspects of clinical laboratory activity, with a special focus on technology development, instrumentation and laboratory management. Fully aware of the fact that the complexity and depth of laboratory practice have undergone an impressive and rapid evolution, the specific goals of the event were to increase knowledge in the fundamentals of new molecular investigation, areas which show the tendency to become routine in our daily activity. In addition, laboratory management and the place of medical laboratories in the process of translational medicine were subjects of focus. The 6th Conference of the Romanian Association of Medical Laboratories was held from Wednesday 1st to Saturday 4th of June 2011. A total of 273 participants from all local branches of the Association attended. The scientific program included seven plenary sessions where 22 lectures and 18 short communications were delivered, and three poster sessions with 44 poster presentations. Session topics covered issues of laboratory diagnostics in hematology, biochemistry, immunology, oncology, microbiology and metabolic diseases. A prominent consideration was given to value added to laboratory medicine in the frame of managed care and quality management. The Conference was accompanied by a laboratory equipment and reagents exhibition with the participation of nine companies, also sponsors of the conference. Three workshops pointed out the presence of the most well known of them: Abbott, Roche and Nobis.
Parathyroid surgical failures with sufficient decline of intraoperative parathyroid hormone levels: unobserved multiple endocrine neoplasia as an explanation.

PubMed

Westerdahl, Johan; Bergenfelz, Anders

2006-06-01

A sufficient decline in levels of parathyroid hormone measured intraoperatively (ioPTH) precludes early and late surgical failures. A case series of consecutive patients undergoing parathyroidectomy with ioPTH measurement. A university hospital. Two hundred sixty-nine consecutive patients with sporadic primary hyperparathyroidism who underwent first-time parathyroid surgery with ioPTH measurement were followed up for as long as 10 years after surgery. Data on all patients have been collected in a prospective database. Surgical failures up to 10 years after parathyroid surgery. With an average follow-up of 3.6 years (range, 6-120 months), the overall cure rate was 96%. The ioPTH level correctly predicted long-term outcome in 248 (92%) of 269 patients. Six patients had a false-positive ioPTH finding. Five of these patients were found to have germline mutations in the gene for multiple endocrine neoplasia. The remaining patient has not undergone genetic testing. The mutations have rarely (n = 1) or never (n = 4) been described before, to our knowledge. Intraoperative measurement of PTH level has a high overall accuracy with a mean follow-up of 3.6 years. However, among the late surgical failures with false-positive ioPTH findings, overlooked mutations in the multiple endocrine neoplasia gene should be suspected, and therefore genetic analyses in these patients are of great importance.
BioMICADAS: Compact next generation AMS system for pharmaceutical science

NASA Astrophysics Data System (ADS)

Schulze-König, Tim; Dueker, Stephen R.; Giacomo, Jason; Suter, Martin; Vogel, John S.; Synal, Hans-Arno

2010-04-01

The next generation Accelerator Mass Spectrometer system specifically designed to address the needs of the growing pharmaceutical science market has passed validation testing. The system dubbed BioMICADAS is based on a previously developed compact carbon dating instrument, the MICADAS. Like its predecessor, it has an overall footprint of only 2.5 × 3 m 2 and uses a 200 kV high voltage platform for tandem based ion acceleration. The ion source can accommodate samples as graphite or gaseous CO 2. It is equipped with two independently operating vacuum locks, allowing continuous measurement sequence and providing a capacity of ˜20,000 samples per annum. A barcoded cathode tracking system allows data capture into Laboratory Information Management System (LIMS) for Good Laboratory Practices (GLP) regulated work. It can be housed in research laboratories alongside other complementary bioanalytical equipment and operated by general laboratory staff as the system is designed to be robust and user-friendly. The system has undergone rigorous validation over the range from 0.1 to 100 Modern Carbon, including accuracy, linearity, robustness, and precision experiments over the course of 7 months. It has been shipped and installed at the site of our collaborative partner, Vitalea Science in Davis, California. The installation process took ˜2 weeks from boxes to beam. The feasibility of the system to determine the absolute specific activity of biogenic samples was also shown by using the method of isotopic dilution.
Characterizing spatial and temporal variability of dissolved gases in aquatic environments with in situ mass spectrometry.

PubMed

Camilli, Richard; Duryea, Anthony N

2009-07-01

The TETHYS mass spectrometer is intended for long-term in situ observation of dissolved gases and volatile organic compounds in aquatic environments. Its design maintains excellent low mass range sensitivity and stability during long-term operations, enabling characterization of low-frequency variability in many trace dissolved gases. Results are presented from laboratory trials and a 300-h in situ trial in a shallow marine embayment in Massachusetts, U.S.A. This time series consists of over 15000 sample measurements and represents the longest continuous record made by an in situ mass spectrometer in an aquatic environment. These measurements possess sufficient sampling density and duration to apply frequency analysis techniques for study of temporal variability in dissolved gases. Results reveal correlations with specific environmental periodicities. Numerical methods are presented for converting mass spectrometer ion peak ratios to absolute-scale dissolved gas concentrations across wide temperature regimes irrespective of ambient pressure, during vertical water column profiles in a hypoxic deep marine basin off the coast of California, U.S.A. Dissolved oxygen concentration values obtained with the TETHYS instrument indicate close correlation with polarographic oxygen sensor data across the entire depth range. These methods and technology enable observation of aquatic environmental chemical distributions and dynamics at appropriate scales of resolution.
Powering up with indirect reciprocity in a large-scale field experiment.

PubMed

Yoeli, Erez; Hoffman, Moshe; Rand, David G; Nowak, Martin A

2013-06-18

A defining aspect of human cooperation is the use of sophisticated indirect reciprocity. We observe others, talk about others, and act accordingly. We help those who help others, and we cooperate expecting that others will cooperate in return. Indirect reciprocity is based on reputation, which spreads by communication. A crucial aspect of indirect reciprocity is observability: reputation effects can support cooperation as long as peoples' actions can be observed by others. In evolutionary models of indirect reciprocity, natural selection favors cooperation when observability is sufficiently high. Complimenting this theoretical work are experiments where observability promotes cooperation among small groups playing games in the laboratory. Until now, however, there has been little evidence of observability's power to promote large-scale cooperation in real world settings. Here we provide such evidence using a field study involving 2413 subjects. We collaborated with a utility company to study participation in a program designed to prevent blackouts. We show that observability triples participation in this public goods game. The effect is over four times larger than offering a $25 monetary incentive, the company's previous policy. Furthermore, as predicted by indirect reciprocity, we provide evidence that reputational concerns are driving our observability effect. In sum, we show how indirect reciprocity can be harnessed to increase cooperation in a relevant, real-world public goods game.
The components of shear stress affecting insect cells used with the baculovirus expression vector system.

PubMed

Weidner, Tobias; Druzinec, Damir; Mühlmann, Martina; Buchholz, Rainer; Czermak, Peter

2017-09-26

Insect-based expression platforms such as the baculovirus expression vector system (BEVS) are widely used for the laboratory- and industrial-scale production of recombinant proteins. Thereby, major drawbacks to gain high-quality proteins are the lytic infection cycle and the shear sensitivity of infected insect cells due to turbulence and aeration. Smaller bubbles were formerly assumed to be more harmful than larger ones, but we found that cell damage is also dependent on the concentration of protective agents such as Pluronic®. At the appropriate concentration, Pluronic forms a layer around air bubbles and hinders the attachment of cells, thus limiting the damage. In this context, we used microaeration to vary bubble sizes and confirmed that size is not the most important factor, but the total gas surface area in the reactor is. If the surface area exceeds a certain threshold, the concentration of Pluronic is no longer sufficient for cell protection. To investigate the significance of shear forces, a second study was carried out in which infected insect cells were cultivated in a hollow fiber module to protect them from shear forces. Both model studies revealed important aspects of the design and scale-up of BEVS processes for the production of recombinant proteins.
Unraveling the Mysteries of Turbulence Transport in a Wind Farm

DOE PAGES

Jha, Pankaj K.; Duque, Earl P. N.; Bashioum, Jessica L.; ...

2015-06-26

A true physical understanding of the mysteries involved in the recovery process of the wake momentum deficit, downstream of utility-scale wind turbines in the atmosphere, has not been obtained to date. Field data are not acquired at sufficient spatial and temporal resolutions to dissect some of the mysteries of wake turbulence. It is here that the actuator line method has evolved to become the technology standard in the wind energy community. This work presents the actuator line method embedded into an Open source Field Operation and Manipulation (OpenFOAM) large-eddy simulation solver and applies it to two small wind farms, themore » first one consisting of an array of two National Renewable Energy Laboratory 5 Megawatt (NREL 5-MW) turbines separated by seven rotor diameters in neutral and unstable atmospheric boundary-layer flow and the second one consisting of five NREL 5-MW wind turbines in unstable atmospheric conditions arranged in two staggered arrays of two and three turbines, respectively. Detailed statistics involving power spectral density (PSD) of turbine power along with standard deviations reveal the effects of atmospheric turbulence and its space and time scales. In conclusion, high-resolution surface data extracts provide new insight into the complex recovery process of the wake momentum deficit governed by turbulence transport phenomena.« less
Unraveling the Mysteries of Turbulence Transport in a Wind Farm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jha, Pankaj K.; Duque, Earl P. N.; Bashioum, Jessica L.

A true physical understanding of the mysteries involved in the recovery process of the wake momentum deficit, downstream of utility-scale wind turbines in the atmosphere, has not been obtained to date. Field data are not acquired at sufficient spatial and temporal resolutions to dissect some of the mysteries of wake turbulence. It is here that the actuator line method has evolved to become the technology standard in the wind energy community. This work presents the actuator line method embedded into an Open source Field Operation and Manipulation (OpenFOAM) large-eddy simulation solver and applies it to two small wind farms, themore » first one consisting of an array of two National Renewable Energy Laboratory 5 Megawatt (NREL 5-MW) turbines separated by seven rotor diameters in neutral and unstable atmospheric boundary-layer flow and the second one consisting of five NREL 5-MW wind turbines in unstable atmospheric conditions arranged in two staggered arrays of two and three turbines, respectively. Detailed statistics involving power spectral density (PSD) of turbine power along with standard deviations reveal the effects of atmospheric turbulence and its space and time scales. In conclusion, high-resolution surface data extracts provide new insight into the complex recovery process of the wake momentum deficit governed by turbulence transport phenomena.« less
Liposuction for Submental Lymphedema Improves Appearance and Self-Perception in the Head and Neck Cancer Patient.

PubMed

Brake, Maria K; Jain, Lauren; Hart, Robert D; Trites, Jonathan R B; Rigby, Matthew; Taylor, S Mark

2014-08-01

Patients who have undergone treatment for head and neck cancer are at risk for neck lymphedema, which can severely affect quality of life. Liposuction has been used successfully for cancer patients who suffer from posttreatment limb lymphedema. The purpose of our study was to review the outcomes of head and neck cancer patients at our center who have undergone submental liposuction for posttreatment lymphedema. Prospective cohort study. Oncology center in tertiary hospital setting. Head and neck cancer patients who underwent submental liposuction for posttreatment lymphedema were included. Nine patients met the study criteria. Patients completed 2 surveys (Modified Blepharoplasty Outcome Evaluation and the validated Derriford Appearance Scale) pre- and postoperatively to assess satisfaction. Patients' pre- and postoperative photos were graded by independent observers to assess outcomes objectively. Our study demonstrated a statistically significant improvement in patients' self-perception of appearance and statistically significant objective scoring of appearance following submental liposuction. Submental liposuction improves the appearance and quality of life for head and neck cancer patients suffering from posttreatment lymphedema by way of improving their self-perception and self-confidence. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.
Influence of skin peeling procedure in allergic contact dermatitis.

PubMed

Kim, Jung Eun; Park, Hyun Jeong; Cho, Baik Kee; Lee, Jun Young

2008-03-01

The prevalence of allergic contact dermatitis in patients who have previously undergone skin peeling has been rarely studied. We compared the frequency of positive patch test (PT) reactions in a patient group with a history of peeling, to that of a control group with no history of peeling. The Korean standard series and cosmetic series were performed on a total of 262 patients. 62 patients had previously undergone peeling and 200 patients did not. The frequency of positive PT reactions on Korean standard series was significantly higher in the peeling group compared with that of the control group (P < 0.05, chi-square test). However, the most commonly identified allergens were mostly cosmetic-unrelated allergens. The frequency of positive PT reactions on cosmetic series in the peeling group was higher than that of the control group, but lacked statistical significance. The frequency (%) of positive PT reactions on cosmetic series in the high-frequency peel group was higher than that of the low-frequency group, but lacked statistical significance. It appears peeling may not generally affect the development of contact sensitization. Further work is required focusing on the large-scale prospective studies by performing a PT before and after peeling.
Enabling UAS Research at the NASA EAV Laboratory

NASA Technical Reports Server (NTRS)

Ippolito, Corey A.

2015-01-01

The Exploration Aerial Vehicles (EAV) Laboratory at NASA Ames Research Center leads research into intelligent autonomy and advanced control systems, bridging the gap between simulation and full-scale technology through flight test experimentation on unmanned sub-scale test vehicles.
TREATMENT OF INORGANIC CONTAMINANTS USING PERMEABLE REACTIVE BARRIERS

EPA Science Inventory

Permeable reactive barriers are an emerging alternative to traditional pump and treat systems for groundwater remediation. This technique has progressed rapidly over the past decade from laboratory bench-scale studies to full-scale implementation. Laboratory studies indicate the ...
Scale-Dependent Manganese Leaching from Stainless Steel Impacts Terminal Galactosylation in Monoclonal Antibodies.

PubMed

Williamson, Jenna; Miller, Jennifer; McLaughlin, Joseph; Combs, Rodney; Chu, Chia

2018-06-08

N-linked glycosylation profiles are routinely characterized on mammalian-derived protein therapeutic products and achieving consistency in the product-associated glycan attributes is an important indicator that the manufacturing process is under control. More importantly, meeting target glycan profile is a common criterion for ensuring product efficacy. During laboratory process development and subsequent scale up for pilot demonstration for a monoclonal antibody program, discrepancies in the molecule's terminal galactosylation level at 2-L, 100-L, and 6000-L scales were observed. Results from extensive investigations revealed the root cause as manganese leaching from the stainless steel components and that this leaching is dependent on exposed surface area and cultivation time. Although this metal impurity is only present at nanomolar concentrations and difficult to detect, a spike-in study demonstrated that this low level was sufficient to impact the protein glycosylation profiles. Surprisingly, the 2-L glass bioreactor setup exhibited the highest amount of exposure to stainless steel and resulted in both a greater degree of variability and higher overall levels of terminal galactosylation. The use of disposable vessels to minimize stainless steel surface exposure to the cell culture resulted in comparable terminal galactosylation levels to those measured in pilot and commercial bioreactors. The discovery of this leachable effect on the cell culture production process was an essential step in implementing appropriate process control. This article is protected by copyright. All rights reserved. © 2018 American Institute of Chemical Engineers.
U.S. DOE NETL methodology for estimating the prospective CO 2 storage resource of shales at the national and regional scale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levine, Jonathan S.; Fukai, Isis; Soeder, Daniel J.

While the majority of shale formations will serve as reservoir seals for stored anthropogenic carbon dioxide (CO2), hydrocarbon-bearing shale formations may be potential geologic sinks after depletion through primary production. Here in this paper we present the United States-Department of Energy-National Energy Technology Laboratory (US-DOE-NETL) methodology for screening-level assessment of prospective CO 2 storage resources in shale using a volumetric equation. Volumetric resource estimates are produced from the bulk volume, porosity, and sorptivity of the shale and storage efficiency factors based on formation-scale properties and petrophysical limitations on fluid transport. Prospective shale formations require: (1) prior hydrocarbon production using horizontalmore » drilling and stimulation via staged, high-volume hydraulic fracturing, (2) depths sufficient to maintain CO 2 in a supercritical state, generally >800 m, and (3) an overlying seal. The US-DOE-NETL methodology accounts for storage of CO 2 in shale as a free fluid phase within fractures and matrix pores and as an sorbed phase on organic matter and clays. Uncertainties include but are not limited to poorly-constrained geologic variability in formation thickness, porosity, existing fluid content, organic richness, and mineralogy. Knowledge of how these parameters may be linked to depositional environments, facies, and diagenetic history of the shale will improve the understanding of pore-to-reservoir scale behavior, and provide improved estimates of prospective CO 2 storage.« less
U.S. DOE NETL methodology for estimating the prospective CO 2 storage resource of shales at the national and regional scale

DOE PAGES

Levine, Jonathan S.; Fukai, Isis; Soeder, Daniel J.; ...

2016-05-31

While the majority of shale formations will serve as reservoir seals for stored anthropogenic carbon dioxide (CO2), hydrocarbon-bearing shale formations may be potential geologic sinks after depletion through primary production. Here in this paper we present the United States-Department of Energy-National Energy Technology Laboratory (US-DOE-NETL) methodology for screening-level assessment of prospective CO 2 storage resources in shale using a volumetric equation. Volumetric resource estimates are produced from the bulk volume, porosity, and sorptivity of the shale and storage efficiency factors based on formation-scale properties and petrophysical limitations on fluid transport. Prospective shale formations require: (1) prior hydrocarbon production using horizontalmore » drilling and stimulation via staged, high-volume hydraulic fracturing, (2) depths sufficient to maintain CO 2 in a supercritical state, generally >800 m, and (3) an overlying seal. The US-DOE-NETL methodology accounts for storage of CO 2 in shale as a free fluid phase within fractures and matrix pores and as an sorbed phase on organic matter and clays. Uncertainties include but are not limited to poorly-constrained geologic variability in formation thickness, porosity, existing fluid content, organic richness, and mineralogy. Knowledge of how these parameters may be linked to depositional environments, facies, and diagenetic history of the shale will improve the understanding of pore-to-reservoir scale behavior, and provide improved estimates of prospective CO 2 storage.« less
Characterizing GEO Titan IIIC Transtage Fragmentations using Ground-Based and Telescopic Measurements

NASA Technical Reports Server (NTRS)

Cowardin, Heather; Anz-Meador, Phillip; Reyes, Jacqueline A.

2017-01-01

In a continued effort to better characterize the geosynchronous orbit (GEO) environment, NASA's Orbital Debris Program Office (ODPO) utilizes various ground-based optical assets to acquire photometric and spectral data of known debris associated with fragmentations in or near GEO. The Titan IIIC Transtage upper stage is known to have fragmented four times. Two of the four fragmentations were in GEO while the Transtage fragmented a third time in GEO transfer orbit. The forth fragmentation occurred in low Earth orbit. To better assess and characterize these fragmentations, the NASA ODPO acquired a Titan Transtage test and display article previously in the custody of the 309th Aerospace Maintenance and Regeneration Group (AMARG) in Tucson, Arizona. After initial inspections at AMARG demonstrated that it was of sufficient fidelity to be of interest, the test article was brought to NASA Johnson Space Center (JSC) to continue material analysis and historical documentation. The Transtage has undergone two separate spectral measurement campaigns to characterize the reflectance spectroscopy of historical aerospace materials. These data have been incorporated into the NASA Spectral Database, with the goal of using telescopic data comparisons for potential material identification. A Light Detection and Ranging (LIDAR) system scan also has been completed and a scale model has been created for use in the Optical Measurement Center (OMC) for photometric analysis of an intact Transtage, including bidirectional reflectance distribution function (BRDF) measurements. An historical overview of the Titan IIIC Transtage, the current analysis that has been done to date, and the future work to be completed in support of characterizing the GEO and near GEO orbital debris environment will be discussed in the subsequent presentation.
Characterizing GEO Titan IIIC Transtage Fragmentations Using Ground-based and Telescopic Measurements

NASA Astrophysics Data System (ADS)

Cowardin, H.; Anz-Meador, P.; Reyes, J. A.

In a continued effort to better characterize the geosynchronous orbit (GEO) environment, NASA’s Orbital Debris Program Office (ODPO) utilizes various ground-based optical assets to acquire photometric and spectral data of known debris associated with fragmentations in or near GEO. The Titan IIIC Transtage upper stage is known to have fragmented four times. Two of the four fragmentations were in GEO while the Transtage fragmented a third time in GEO transfer orbit. The forth fragmentation occurred in low Earth orbit. To better assess and characterize these fragmentations, the NASA ODPO acquired a Titan Transtage test and display article previously in the custody of the 309th Aerospace Maintenance and Regeneration Group (AMARG) in Tucson, Arizona. After initial inspections at AMARG demonstrated that it was of sufficient fidelity to be of interest, the test article was brought to NASA Johnson Space Center (JSC) to continue material analysis and historical documentation. The Transtage has undergone two separate spectral measurement campaigns to characterize the reflectance spectroscopy of historical aerospace materials. These data have been incorporated into the NASA Spectral Database, with the goal of using telescopic data comparisons for potential material identification. A Light Detection and Ranging (LIDAR) system scan also has been completed and a scale model has been created for use in the Optical Measurement Center (OMC) for photometric analysis of an intact Transtage, including bidirectional reflectance distribution function (BRDF) measurements. An historical overview of the Titan IIIC Transtage, the current analysis that has been done to date, and the future work to be completed in support of characterizing the GEO and near GEO orbital debris environment will be discussed in the subsequent presentation.
Nanoscale heterogeneity as remnant hexagonal-type local structures in shocked Cu-Pb and Zr

NASA Astrophysics Data System (ADS)

Tayal, Akhil; Conradson, Steven D.; Batuk, Olga N.; Fensin, Saryu; Cerreta, Ellen; Gray, George T.; Saxena, Avadh

2017-09-01

Extended X-ray absorption fine structure spectroscopy was used to determine the local structure in: (1) Zr that had undergone quasistatic elongation; (2) Zr that had undergone plastic deformation by shock at pressures above and below the ω-phase transformation; and (3) shocked Cu that contained a few percent of insoluble Pb. Below the transition pressure, Zr samples showed only general disorder as increases in the widths of the Zr-Zr pair distributions. Above this pressure, Zr that was a mixture of the original hcp and the high pressure ω-phase when measured by diffraction showed two sets of peaks in its distribution corresponding to these two phases. Some of the ones from the ω-phase were at distances substantially different from those calculated from the diffraction pattern, although they are still consistent with small domains exhibiting stacking faults associated with hexagonal-type structural components exhibiting variability in the [0001] basal plane spacing. A similar result, new pairs at just over 3 and 4 Å consistent with hexagonal-type stacking faults in addition to the original fcc structure, is found in shocked Cu despite the absence of a second diffraction pattern and peak pressures being far below those expected to induce an fcc to hcp transition. This result, therefore, demonstrates that the correlation between high strain rates and reduced stacking fault energy continues down to the length scale of atom pairs. These findings are significant as: (1) a microscopic description of the behavior of systems far from equilibrium; (2) a demonstration of the importance of strain rate at short length scales; and (3) a bridge between the abruptness of macroscopic pressure-induced phase transitions and the continuity of martensitic ones over their fluctuation region in terms of the inverse relationship between the length scale of the martensitic texture, manifested here as ordered lattice distortions and the lower pressure at which such texture first appears relative to the bulk transition pressure.

Practical biosafety in the tuberculosis laboratory: containment at the source is what truly counts.

PubMed

van Soolingen, D; Wisselink, H J; Lumb, R; Anthony, R; van der Zanden, A; Gilpin, C

2014-08-01

In industrialised countries, sufficient resources for establishing and maintaining fully equipped biosafety level 3 (BSL-3) laboratories according to international standards are generally available. BSL-3 laboratories are designed to provide several layers of containment to protect the laboratory worker as well as the outside environment and community from risk of exposure in case of local contamination. However, such facilities are scarce in high-burden settings, primarily due to the high financial burden and complexity of the initial construction and/or regular maintenance. Measures to prevent unintended exposure to Mycobacterium tuberculosis during laboratory manipulation of specimens and cultures is the first, and by far the most important, aspect of containment. This paper focuses on the need for risk containment at source. Assuming that in many settings the establishment of BSL-3 laboratories with all the required features is not achievable, this paper also discusses the minimum requirements necessary to mitigate risks associated with particular laboratory procedures. The term 'TB containment laboratory' is used throughout this paper to describe the minimum requirements for a laboratory suitable for high-risk procedures. The TB containment laboratory has many, but not all, of the features of a BSL-3 laboratory.
Making Carbon Emissions Remotely Sensible: Flux Observations of Carbon from an Airborne Laboratory (FOCAL), its Near-Surface Survey of Carbon Gases and Isotopologues on Alaska's North Slope

NASA Astrophysics Data System (ADS)

Dobosy, R.; Dumas, E. J.; Sayres, D. S.; Healy, C. E.; Munster, J. B.; Baker, B.; Anderson, J. G.

2014-12-01

Detailed process-oriented study of the mechanisms of conversion in the Arctic of fossil carbon to atmospheric gas is progressing, but necessarily limited to a few point locations and requiring detailed subsurface measurements inaccessible to remote sensing. Airborne measurements of concentration, transport and flux of these carbon gases at sufficiently low altitude to reflect surface variations can tie such local measurements to remotely observable features of the landscape. Carbon dioxide and water vapor have been observable for over 20 years from low-altitude small aircraft in the Arctic and elsewhere. Methane has been more difficult, requiring large powerful aircraft or limited flask samples. Recent developments in spectroscopy, however, have reduced the power and weight required to measure methane at rates suitable for eddy-covariance flux estimates. The Flux Observations of Carbon from an Airborne Laboratory (FOCAL) takes advantage of Integrated Cavity-Output Spectroscopy (ICOS) to measure CH4, CO2, and water vapor in a new airborne system. The system, moreover, measures these gases' stable isotopologues every two seconds or faster helping to separate thermogenic from biogenic emissions. Paired with the Best Airborne Turbulence (BAT) probe developed for small aircraft by NOAA's Air Resources Laboratory and a light twin-engine aircraft adapted by Aurora Flight Sciences Inc., the FOCAL measures at 6 m spacing, covering 100 km in less than 30 minutes. It flies between 10 m and 50 m above ground interspersed with profiles to the top of the boundary layer and beyond. This presentation gives an overview of the magnitude and variation in fluxes and concentrations of CH4, CO2, and H2O with space, time, and time of day in a spatially extensive survey, more than 7500 km total in 15 flights over roughly a 100 km square during the month of August 2013. An extensive data set such as this at low altitude with high-rate sampling addresses features that repeat on 1 km scale or smaller such as thermokarst lakes as well as landscape changes on the 100 km scale.
Acoustic Treatment Design Scaling Methods. Volume 3; Test Plans, Hardware, Results, and Evaluation

NASA Technical Reports Server (NTRS)

Yu, J.; Kwan, H. W.; Echternach, D. K.; Kraft, R. E.; Syed, A. A.

1999-01-01

The ability to design, build, and test miniaturized acoustic treatment panels on scale-model fan rigs representative of the full-scale engine provides not only a cost-savings, but an opportunity to optimize the treatment by allowing tests of different designs. To be able to use scale model treatment as a full-scale design tool, it is necessary that the designer be able to reliably translate the scale model design and performance to an equivalent full-scale design. The primary objective of the study presented in this volume of the final report was to conduct laboratory tests to evaluate liner acoustic properties and validate advanced treatment impedance models. These laboratory tests include DC flow resistance measurements, normal incidence impedance measurements, DC flow and impedance measurements in the presence of grazing flow, and in-duct liner attenuation as well as modal measurements. Test panels were fabricated at three different scale factors (i.e., full-scale, half-scale, and one-fifth scale) to support laboratory acoustic testing. The panel configurations include single-degree-of-freedom (SDOF) perforated sandwich panels, SDOF linear (wire mesh) liners, and double-degree-of-freedom (DDOF) linear acoustic panels.
Acoustic emission characterization of microcracking in laboratory-scale hydraulic fracturing tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hampton, Jesse; Gutierrez, Marte; Matzar, Luis

Understanding microcracking near coalesced fracture generation is critically important for hydrocarbon and geothermal reservoir characterization as well as damage evaluation in civil engineering structures. Dense and sometimes random microcracking near coalesced fracture formation alters the mechanical properties of the nearby virgin material. Individual microcrack characterization is also significant in quantifying the material changes near the fracture faces (i.e. damage). Acoustic emission (AE) monitoring and analysis provide unique information regarding the microcracking process temporally, and information concerning the source characterization of individual microcracks can be extracted. In this context, laboratory hydraulic fracture tests were carried out while monitoring the AEs frommore » several piezoelectric transducers. In-depth post-processing of the AE event data was performed for the purpose of understanding the individual source mechanisms. Several source characterization techniques including moment tensor inversion, event parametric analysis, and volumetric deformation analysis were adopted. Post-test fracture characterization through coring, slicing and micro-computed tomographic imaging was performed to determine the coalesced fracture location and structure. Distinct differences in fracture characteristics were found spatially in relation to the openhole injection interval. Individual microcrack AE analysis showed substantial energy reduction emanating spatially from the injection interval. Lastly, it was quantitatively observed that the recorded AE signals provided sufficient information to generalize the damage radiating spatially away from the injection wellbore.« less
Acoustic emission characterization of microcracking in laboratory-scale hydraulic fracturing tests

DOE PAGES

Hampton, Jesse; Gutierrez, Marte; Matzar, Luis; ...

2018-06-11

Understanding microcracking near coalesced fracture generation is critically important for hydrocarbon and geothermal reservoir characterization as well as damage evaluation in civil engineering structures. Dense and sometimes random microcracking near coalesced fracture formation alters the mechanical properties of the nearby virgin material. Individual microcrack characterization is also significant in quantifying the material changes near the fracture faces (i.e. damage). Acoustic emission (AE) monitoring and analysis provide unique information regarding the microcracking process temporally, and information concerning the source characterization of individual microcracks can be extracted. In this context, laboratory hydraulic fracture tests were carried out while monitoring the AEs frommore » several piezoelectric transducers. In-depth post-processing of the AE event data was performed for the purpose of understanding the individual source mechanisms. Several source characterization techniques including moment tensor inversion, event parametric analysis, and volumetric deformation analysis were adopted. Post-test fracture characterization through coring, slicing and micro-computed tomographic imaging was performed to determine the coalesced fracture location and structure. Distinct differences in fracture characteristics were found spatially in relation to the openhole injection interval. Individual microcrack AE analysis showed substantial energy reduction emanating spatially from the injection interval. Lastly, it was quantitatively observed that the recorded AE signals provided sufficient information to generalize the damage radiating spatially away from the injection wellbore.« less
Transient effects of sudden changes of heat load in a naturally ventilated room

NASA Astrophysics Data System (ADS)

Caulfield, C. P.; Bower, D. J.; Fitzgerald, S.; Woods, A. W.

2006-11-01

Using reduced numerical models and small-scale laboratory experiments, we investigate the transient effects of changing isolated heat loads discontinuously within a large, ventilated space. We consider the emptying filling box (with high and low openings) driven by a single isolated source of buoyancy. The original steady state consists of a buoyant layer, whose depth (for the simplest case of a point source plume) is determined by the geometric properties of the room alone. When the buoyancy flux of the source is increased, a new layer `fills' the room from the top with a more buoyant layer. The original layer disappears due to entrainment by the rising plume. The behaviour is qualitatively different when the source buoyancy flux is decreased. In this case, the rising plume fluid is now relatively dense, and so it inevitably collapses back to `intrude' below the original layer. In this case, the original layer disappears due to both draining through the upper opening, and penetrative entrainment by the dense plume. We compare the predictions of three numerical models using different penetrative entrainment parametrizations to a sequence of laboratory experiments. This entrainment reduces the density of the intruding layer, and so the rising plume eventually stalls, and no longer reaches the (draining) original layer. We demonstrate that it is necessary to consider the transient effects of penetrative entrainment when the reduction in source buoyancy flux is sufficiently small.
Maintaining Quality of Candidate Strains of Transgenic Mosquitoes for Studies in Containment Facilities in Disease Endemic Countries

PubMed Central

Leach, Adrian W.; Benedict, Mark Q.; Facchinelli, Luca; Quinlan, M. Megan

2018-01-01

Abstract Transgenic mosquitoes are being developed as novel components of area-wide approaches to vector-borne disease control. Best practice is to develop these in phases, beginning with laboratory studies, before moving to field testing and inclusion in control programs, to ensure safety and prevent costly field testing of unsuitable strains. The process of identifying and developing good candidate strains requires maintenance of transgenic colonies over many generations in containment facilities. By working in disease endemic countries with target vector populations, laboratory strains may be developed and selected for properties that will enhance intended control efficacy in the next phase, while avoiding traits that introduce unnecessary risks. Candidate strains aiming toward field use must consistently achieve established performance criteria, throughout the process of scaling up from small study colonies to production of sufficient numbers for field testing and possible open release. Maintenance of a consistent quality can be demonstrated by a set of insect quality and insectary operating indicators, measured over time at predetermined intervals. These indicators: inform comparability of studies using various candidate strains at different times and locations; provide evidence of conformity relevant to compliance with terms of approval for regulated use; and can be used to validate some assumptions related to risk assessments covering the contained phase and for release into the environment. PMID:29337661
Maintaining Quality of Candidate Strains of Transgenic Mosquitoes for Studies in Containment Facilities in Disease Endemic Countries.

PubMed

Mumford, John D; Leach, Adrian W; Benedict, Mark Q; Facchinelli, Luca; Quinlan, M Megan

2018-01-01

Transgenic mosquitoes are being developed as novel components of area-wide approaches to vector-borne disease control. Best practice is to develop these in phases, beginning with laboratory studies, before moving to field testing and inclusion in control programs, to ensure safety and prevent costly field testing of unsuitable strains. The process of identifying and developing good candidate strains requires maintenance of transgenic colonies over many generations in containment facilities. By working in disease endemic countries with target vector populations, laboratory strains may be developed and selected for properties that will enhance intended control efficacy in the next phase, while avoiding traits that introduce unnecessary risks. Candidate strains aiming toward field use must consistently achieve established performance criteria, throughout the process of scaling up from small study colonies to production of sufficient numbers for field testing and possible open release. Maintenance of a consistent quality can be demonstrated by a set of insect quality and insectary operating indicators, measured over time at predetermined intervals. These indicators: inform comparability of studies using various candidate strains at different times and locations; provide evidence of conformity relevant to compliance with terms of approval for regulated use; and can be used to validate some assumptions related to risk assessments covering the contained phase and for release into the environment.
Stratigraphic architecture of hydromagmatic volcanoes that have undergone vent migration: a review of Korean case studies

NASA Astrophysics Data System (ADS)

Sohn, Y.

2011-12-01

Recent studies show that the architecture of hydromagmatic volcanoes is far more complex than formerly expected. A number of external factors, such as paleohydrology and tectonics, in addition to magmatic processes are thought to play a role in controlling the overall characteristics and architecture of these volcanoes. One of the main consequences of these controls is the migration of the active vent during eruption. Case studies of hydromagmatic volcanoes in Korea show that those volcanoes that have undergone vent migration are characterized by superposition or juxtaposition of multiple rim deposits of partial tuff rings and/or tuff cones that have contrasting lithofacies characteristics, bed attitudes, and paleoflow directions. Various causes of vent migration are inferred from these volcanoes. Large-scale collapse of fragile substrate is interpreted to have caused vent migration in the Early Pleistocene volcanoes of Jeju Island, which were built upon still unconsolidated continental shelf sediments. Late Pleistocene to Holocene volcanoes, which were built upon a stack of rigid, shield-forming lava flows, lack features due to large-scale substrate collapse and have generally simple and circular morphologies either of a tuff ring or of a tuff cone. However, ~600 m shift of the eruptive center is inferred from one of these volcanoes (Ilchulbong tuff cone). The vent migration in this volcano is interpreted to have occurred because the eruption was sourced by multiple magma batches with significant eruptive pauses in between. The Yangpori diatreme in a Miocene terrestrial half-graben basin in SE Korea is interpreted to be a subsurface equivalent of a hydromagmatic volcano that has undergone vent migration. The vent migration here is inferred to have had both vertical and lateral components and have been caused by an abrupt tectonic activity near the basin margin. In all these cases, rimbeds or diatreme fills derived from different source vents are bounded by either prominent or subtle, commonly laterally extensive truncation surfaces or stratigraphic discontinuities. Careful documentation of these surfaces and discontinuities thus appears vital to proper interpretation of eruption history, morphologic evolution, and even deep-seated magmatic processes of a hydromagmatic volcano. In this respect, the technique known as 'allostratigraphy' appears useful in mapping, correlation, and interpretation of many hydrovolcanic edifices and sequences.
FLARE: A New User Facility for Laboratory Studies of Multiple-Scale Physics of Magnetic Reconnection and Related Phenomena in Heliophysics and Astrophysics

NASA Astrophysics Data System (ADS)

Ji, H.; Bhattacharjee, A.; Goodman, A.; Prager, S.; Daughton, W.; Cutler, R.; Fox, W.; Hoffmann, F.; Kalish, M.; Kozub, T.; Jara-Almonte, J.; Myers, C.; Ren, Y.; Sloboda, P.; Yamada, M.; Yoo, J.; Bale, S. D.; Carter, T.; Dorfman, S.; Drake, J.; Egedal, J.; Sarff, J.; Wallace, J.

2017-10-01

The FLARE device (Facility for Laboratory Reconnection Experiments; flare.pppl.gov) is a new laboratory experiment under construction at Princeton with first plasmas expected in the fall of 2017, based on the design of Magnetic Reconnection Experiment (MRX; mrx.pppl.gov) with much extended parameter ranges. Its main objective is to provide an experimental platform for the studies of magnetic reconnection and related phenomena in the multiple X-line regimes directly relevant to space, solar, astrophysical and fusion plasmas. The main diagnostics is an extensive set of magnetic probe arrays, simultaneously covering multiple scales from local electron scales ( 2 mm), to intermediate ion scales ( 10 cm), and global MHD scales ( 1 m). Specific example space physics topics which can be studied on FLARE will be discussed.
Laboratory Information Systems in Molecular Diagnostics: Why Molecular Diagnostics Data are Different.

PubMed

Lee, Roy E; Henricks, Walter H; Sirintrapun, Sahussapont J

2016-03-01

Molecular diagnostic testing presents new challenges to information management that are yet to be sufficiently addressed by currently available information systems for the molecular laboratory. These challenges relate to unique aspects of molecular genetic testing: molecular test ordering, informed consent issues, diverse specimen types that encompass the full breadth of specimens handled by traditional anatomic and clinical pathology information systems, data structures and data elements specific to molecular testing, varied testing workflows and protocols, diverse instrument outputs, unique needs and requirements of molecular test reporting, and nuances related to the dissemination of molecular pathology test reports. By satisfactorily addressing these needs in molecular test data management, a laboratory information system designed for the unique needs of molecular diagnostics presents a compelling reason to migrate away from the current paper and spreadsheet information management that many molecular laboratories currently use. This paper reviews the issues and challenges of information management in the molecular diagnostics laboratory.
Cross-industry dimensionality of the commitment to change scale in China.

PubMed

Chen, Jingqiu; Wang, Lei

2011-06-01

Commitment to organizational change can explain a range of employees' attitudes and behaviors during organizational change, and its measurement is central to explaining such organizational linkages. The purpose of this study is to re-examine the dimensionality of Herscovitch and Meyer's Commitment to Change Scale across two different industrial samples in a non-Western cultural context (China). The two samples were 198 civil servants (60.0% men; M age = 29.3 yr., M organizational tenure = 62.7 mo.) and 442 high-tech company employees (58.2% men; M age = 30.5 yr., M organizational tenure = 66.5 mo.) who had respectively undergone major changes in compensation and performance appraisal systems in their organizations at the time of the research. Results of exploratory and confirmatory factor analyses showed that a four-factor model with 14 items fit the data best in both samples. The generality of the scale's structure as well as its implications for change-management practices are discussed.
Global warming in the context of 2000 years of Australian alpine temperature and snow cover.

PubMed

McGowan, Hamish; Callow, John Nikolaus; Soderholm, Joshua; McGrath, Gavan; Campbell, Micheline; Zhao, Jian-Xin

2018-03-13

Annual resolution reconstructions of alpine temperatures are rare, particularly for the Southern Hemisphere, while no snow cover reconstructions exist. These records are essential to place in context the impact of anthropogenic global warming against historical major natural climate events such as the Roman Warm Period (RWP), Medieval Climate Anomaly (MCA) and Little Ice Age (LIA). Here we show for a marginal alpine region of Australia using a carbon isotope speleothem reconstruction, warming over the past five decades has experienced equivalent magnitude of temperature change and snow cover decline to the RWP and MCA. The current rate of warming is unmatched for the past 2000 years and seasonal snow cover is at a minimum. On scales of several decades, mean maximum temperatures have undergone considerable change ≈ ± 0.8 °C highlighting local scale susceptibility to rapid temperature change, evidence of which is often masked in regional to hemisphere scale temperature reconstructions.
Development of a Self-Report Measure of Reward Sensitivity:A Test in Current and Former Smokers.

PubMed

Hughes, John R; Callas, Peter W; Priest, Jeff S; Etter, Jean-Francois; Budney, Alan J; Sigmon, Stacey C

2017-06-01

Tobacco use or abstinence may increase or decrease reward sensitivity. Most existing measures of reward sensitivity were developed decades ago, and few have undergone extensive psychometric testing. We developed a 58-item survey of the anticipated enjoyment from, wanting for, and frequency of common rewards (the Rewarding Events Inventory-REI). The current analysis focuses on ratings of anticipated enjoyment. The first validation study recruited current and former smokers from Internet sites. The second study recruited smokers who wished to quit and monetarily reinforced them to stay abstinent in a laboratory study and a comparison group of former smokers. In both studies, participants completed the inventory on two occasions, 3-7 days apart. They also completed four anhedonia scales and a behavioral test of reduced reward sensitivity. Half of the enjoyment ratings loaded on four factors: socializing, active hobbies, passive hobbies, and sex/drug use. Cronbach's alpha coefficients were all ≥0.73 for overall mean and factor scores. Test-retest correlations were all ≥0.83. Correlations of the overall and factor scores with frequency of rewards and anhedonia scales were 0.19-0.53, except for the sex/drugs factor. The scores did not correlate with behavioral tests of reward and did not differ between current and former smokers. Lower overall mean enjoyment score predicted a shorter time to relapse. Internal reliability and test-retest reliability of the enjoyment outcomes of the REI are excellent, and construct and predictive validity are modest but promising. The REI is comprehensive and up-to-date, yet is short enough to use on repeated occasions. Replication tests, especially predictive validity tests, are needed. Both use of and abstinence from nicotine appear to increase or decrease how rewarding nondrug rewards are; however, self-report scales to test this have limitations. Our inventory of enjoyment from 58 rewards appears to be reliable and valid as well as comprehensive and up-to-date, yet is short enough to use on repeated occasions. Replication tests, especially of the predictive validity of our scale, are needed. © The Author 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Genetically engineered silk-collagen-like copolymer for biomedical applications: production, characterization and evaluation of cellular response.

PubMed

Włodarczyk-Biegun, Małgorzata K; Werten, Marc W T; de Wolf, Frits A; van den Beucken, Jeroen J J P; Leeuwenburgh, Sander C G; Kamperman, Marleen; Cohen Stuart, Martien A

2014-08-01

Genetically engineered protein polymers (GEPP) are a class of multifunctional materials with precisely controlled molecular structure and property profile. Representing a promising alternative for currently used materials in biomedical applications, GEPP offer multiple benefits over natural and chemically synthesized polymers. However, producing them in sufficient quantities for preclinical research remains challenging. Here, we present results from an in vitro cellular response study of a recombinant protein polymer that is soluble at low pH but self-organizes into supramolecular fibers and physical hydrogels at neutral pH. It has a triblock structure denoted as C2S(H)48C2, which consists of hydrophilic collagen-inspired and histidine-rich silk-inspired blocks. The protein was successfully produced by the yeast Pichia pastoris in laboratory-scale bioreactors, and it was purified by selective precipitation. This efficient and inexpensive production method provided material of sufficient quantities, purity and sterility for cell culture study. Rheology and erosion studies showed that it forms hydrogels exhibiting long-term stability, self-healing behavior and tunable mechanical properties. Primary rat bone marrow cells cultured in direct contact with these hydrogels remained fully viable; however, proliferation and mineralization were relatively low compared to collagen hydrogel controls, probably because of the absence of cell-adhesive motifs. As biofunctional factors can be readily incorporated to improve material performance, our approach provides a promising route towards biomedical applications. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Contemplative Neuroscience as an Approach to Volitional Consciousness

NASA Astrophysics Data System (ADS)

Thompson, Evan

This chapter presents a methodological approach to volitional consciousness for cognitive neuroscience based on studying the voluntary self-generation and self-regulation of mental states in meditation. Called contemplative neuroscience, this approach views attention, awareness, and emotion regulation as flexible and trainable skills, and works with experimental participants who have undergone training in contemplative practices designed to hone these skills. Drawing from research on the dynamical neural correlates of contemplative mental states and theories of large-scale neural coordination dynamics, I argue for the importance of global system causation in brain activity and present an "interventionist" approach to intentional causation.
GYC: A program to compute the turbulent boundary layer on a rotating cone

NASA Technical Reports Server (NTRS)

Sullivan, R. D.

1976-01-01

A computer program, GYC, which is capable of computing the properties of a compressible turbulent boundary layer on a rotating axisymmetric cone-cylinder body, according to the principles of invariant modeling was studied. The program is extended to include the calculation of the turbulence scale by a differential equation. GYC is in operation on the CDC-7600 computer and has undergone several corrections and improvements as a result of the experience gained. The theoretical basis for the program and the method of implementation, as well as information on its operation are given.
Development and Validation of a Predictive Model to Assess the Impact of Coastal Operations On Urban Scale Air Quality

DTIC Science & Technology

2006-09-29

originating in Los Angeles. The long ridge of ozone in the north east part of Figure 14a is due to polluted air from San Diego area that has undergone...Further north of this small ridge (2 ppbv), we find a decrease in O3 of up to 6ppb (i.e., without DoD emissions, O3 is reduced by 6ppb). This period is...ships on urban air quality. 35 6.0 References Alexis, A., P. Gaffney , C. Garcia, M. Nystrom, and R. Rood (2000), The 1999 California Almanac of
Semiconductor Chemical Reactor Engineering and Photovoltaic Unit Operations.

ERIC Educational Resources Information Center

Russell, T. W. F.

1985-01-01

Discusses the nature of semiconductor chemical reactor engineering, illustrating the application of this engineering with research in physical vapor deposition of cadmium sulfide at both the laboratory and unit operations scale and chemical vapor deposition of amorphous silicon at the laboratory scale. (JN)
Laboratory rearing of bed bugs

USDA-ARS?s Scientific Manuscript database

The resurgence of bed bugs Cimex lectularius L. in the United States and worldwide has resulted in an increase in research by university, government, and industry scientists directed at the biology and control of this blood-sucking pest. A need has subsequently arisen for producing sufficient biolog...

3 CFR - Preemption

Code of Federal Regulations, 2010 CFR

2010-01-01

... preemption by the Congress or an otherwise sufficient basis under applicable legal principles. The purpose of... principles that reflect these circumstances and values. As Justice Brandeis explained more than 70 years ago... citizens choose, serve as a laboratory; and try novel social and economic experiments without risk to the...
A Review of Secondary Organic Aerosol (SOA) Formation from Isoprene

EPA Science Inventory

Recent field and laboratory evidence indicates that the oxidation of isoprene forms secondary organic aerosol (SOA). Global biogenic emissions of isoprene (600 Tg yr^-1) are sufficiently large the formation of SOA is even small yields results in substantial production ...
APL - North Pacific Acoustic Laboratory

DTIC Science & Technology

2015-03-04

PhilSea10 cruise were spent in a series of upgrades and associated tests of the TCTD system. Electronic upgrades in conjunction with the manufacturers, ADM...amplitude at positions sufficiently removed from caustics . Mr. White computed eigenrays to all tracked upper array hydrophone positions relative to each
Acoustic Scattering Models of Zooplankton and Microstructure

DTIC Science & Technology

1998-09-30

siphonophores ) in a laboratory tank produced significant echoes. However, we could only hypothesize on what the scattering levels could be in the natural... siphonophores and pteropods) that have high enough target strengths and occur in sufficiently high numbers that they could interfere with the performance
A Hybrid Soft-computing Method for Image Analysis of Digital Plantar Scanners.

PubMed

Razjouyan, Javad; Khayat, Omid; Siahi, Mehdi; Mansouri, Ali Alizadeh

2013-01-01

Digital foot scanners have been developed in recent years to yield anthropometrists digital image of insole with pressure distribution and anthropometric information. In this paper, a hybrid algorithm containing gray level spatial correlation (GLSC) histogram and Shanbag entropy is presented for analysis of scanned foot images. An evolutionary algorithm is also employed to find the optimum parameters of GLSC and transform function of the membership values. Resulting binary images as the thresholded images are undergone anthropometric measurements taking in to account the scale factor of pixel size to metric scale. The proposed method is finally applied to plantar images obtained through scanning feet of randomly selected subjects by a foot scanner system as our experimental setup described in the paper. Running computation time and the effects of GLSC parameters are investigated in the simulation results.
Psychometrics and its discontents: an historical perspective on the discourse of the measurement tradition.

PubMed

Schoenherr, Jordan Richard; Hamstra, Stanley J

2016-08-01

Psychometrics has recently undergone extensive criticism within the medical education literature. The use of quantitative measurement using psychometric instruments such as response scales is thought to emphasize a narrow range of relevant learner skills and competencies. Recent reviews and commentaries suggest that a paradigm shift might be presently underway. We argue for caution, in that the psychometrics approach and the quantitative account of competencies that it reflects is based on a rich discussion regarding measurement and scaling that led to the establishment of this paradigm. Rather than reflecting a homogeneous discipline focused on core competencies devoid of consideration of context, the psychometric community has a history of discourse and debate within the field, with an acknowledgement that the techniques and instruments developed within psychometrics are heuristics that must be used pragmatically.
Consolidation of cloud computing in ATLAS

NASA Astrophysics Data System (ADS)

Taylor, Ryan P.; Domingues Cordeiro, Cristovao Jose; Giordano, Domenico; Hover, John; Kouba, Tomas; Love, Peter; McNab, Andrew; Schovancova, Jaroslava; Sobie, Randall; ATLAS Collaboration

2017-10-01

Throughout the first half of LHC Run 2, ATLAS cloud computing has undergone a period of consolidation, characterized by building upon previously established systems, with the aim of reducing operational effort, improving robustness, and reaching higher scale. This paper describes the current state of ATLAS cloud computing. Cloud activities are converging on a common contextualization approach for virtual machines, and cloud resources are sharing monitoring and service discovery components. We describe the integration of Vacuum resources, streamlined usage of the Simulation at Point 1 cloud for offline processing, extreme scaling on Amazon compute resources, and procurement of commercial cloud capacity in Europe. Finally, building on the previously established monitoring infrastructure, we have deployed a real-time monitoring and alerting platform which coalesces data from multiple sources, provides flexible visualization via customizable dashboards, and issues alerts and carries out corrective actions in response to problems.
Spatially explicit modeling of particulate nutrient flux in Large global rivers

NASA Astrophysics Data System (ADS)

Cohen, S.; Kettner, A.; Mayorga, E.; Harrison, J. A.

2017-12-01

Water, sediment, nutrient and carbon fluxes along river networks have undergone considerable alterations in response to anthropogenic and climatic changes, with significant consequences to infrastructure, agriculture, water security, ecology and geomorphology worldwide. However, in a global setting, these changes in fluvial fluxes and their spatial and temporal characteristics are poorly constrained, due to the limited availability of continuous and long-term observations. We present results from a new global-scale particulate modeling framework (WBMsedNEWS) that combines the Global NEWS watershed nutrient export model with the spatially distributed WBMsed water and sediment model. We compare the model predictions against multiple observational datasets. The results indicate that the model is able to accurately predict particulate nutrient (Nitrogen, Phosphorus and Organic Carbon) fluxes on an annual time scale. Analysis of intra-basin nutrient dynamics and fluxes to global oceans is presented.
Yeast enolase: mechanism of activation by metal ions.

PubMed

Brewer, J M

1981-01-01

Yeast enolase as prepared by current procedures is inherently chemically homogeneous, though deamidation and partial denaturation can produce electrophoretically distinct forms. A true isozyme of the enzyme exists but does not survive the purification procedure. The chemical sequence for both has been established. The enzyme behaves in solution like a compact, nearly spherical molecule of moderate hydration. Strong intramolecular forces maintain the structure of the individual subunits. The enzyme as isolated is dimeric. If dissociated in the presence of magnesium ions and substrate, then the subunits are active, but if the dissociation occurs in the absence of metal ions, they are inactive until they have reassociated and undergone a first order "annealing" process. Magnesium (II) enhances association. The interaction between the subunits is hydrophobic in character. The enzyme can bind up to 2 mol of most metal ions in "conformational" sites which then allows up to 2 mol of substrate or some substrate analogue to bind. This is not sufficient for catalysis, but conformational metal ions do more than just allow substrate binding. A change in the environment of the metal ions occurs on substrate or substrate analogue binding. There is an absolute correlation between the occurrence of a structural change undergone by the 3-amino analogue of phosphoenolpyruvate and whether the metal ions produce any level of enzymatic activity. For catalysis, two more moles of metal ions, called "catalytic", must bind. There is evidence that the enzymatic reaction involves a carbanion mechanism. It is likely that two more moles of metal ion can bind which inhibit the reaction. The requirement for 2 mol of metal ion per subunit which contribute in different ways to catalysis is exhibited by a number of other enzymes.
Manufacturing Laboratory | Energy Systems Integration Facility | NREL

Science.gov Websites

Manufacturing Laboratory Manufacturing Laboratory Researchers in the Energy Systems Integration Facility's Manufacturing Laboratory develop methods and technologies to scale up renewable energy technology manufacturing capabilities. Photo of researchers and equipment in the Manufacturing Laboratory. Capability Hubs
Usefulness of a Perceived Exertion Scale for Monitoring Exercise Intensity in Adults with Intellectual Disabilities

ERIC Educational Resources Information Center

Stanish, Heidi I.; Aucoin, Michael

2007-01-01

In order to gain physical fitness and health, exercise must be performed at a sufficient level of intensity. Exercise intensity can be monitored with rated perceived exertion (RPE) scales to promote safe and effective programming. The usefulness of the Children's OMNI Scale as a subjective measure of intensity for adults with intellectual…
Study and assessment of segregated biowaste composting: The case study of Attica municipalities.

PubMed

Malamis, D; Bourka, A; Stamatopoulou, Ε; Moustakas, K; Skiadi, O; Loizidou, M

2017-12-01

This work aims to assess the operation of the first large scale segregated biowaste composting scheme in Greece to divert Household Food Waste (HFW) from landfill and produce a material which can be recovered and used as compost. The source separation and collection of HFW was deployed in selected areas in Attica Region serving about 3700 households. Sorted HFW is collected & transported to the Mechanical and Biological Treatment (MBT) plant in Attica Region that has been designed to produce Compost Like Output (CLO) from mixed MSW. The MBT facility has been adjusted in order to receive and treat aerobically HFW mixed with shredded green waste in a dedicated composting tunnel. The composting process was monitored against temperature, moisture and oxygen content indicating that the biological conditions are sufficiently developed. The product quality was examined and assessed against the quality specifications of EU End of Waste Criteria for biowaste subjected to composting aiming to specify whether the HFW that has undergone recovery ceases to be waste and can be classified as compost. More specifically, the heavy metals concentrations (Cr, Cu, Ni, Cd, Pb, Zn and Hg) are within the set limits and much lower compared to the CLO material that currently is being produced at the MBT plant. In regard to the hygienic requirements of the product it has been found that the process conditions result in a pathogen free material (i.e. E. Coli and Salmonella) which does not favor the growth of viable weeds and plant propagules, while it acquires sufficient organic matter content for soil fertilization. Noticeable physical impurities (mainly fractions of glass) have been detected exceeding the quality control threshold limit of 0.5% w/w (plastics, metals and glass). The latter is related to the missorted materials and to the limited pre-treatment configurations prior to composting. The above findings indicate that effective source separation of biowaste is prerequisite for good quality production and marketing of compost and special consideration should be made to minimize glass impurities prior composting (i.e. awareness raising and pretreatment stage). Therefore, it is feasible to gradually replace the production of questionable quality CLO in MBTs with biowaste compost which is in line with the required quality control standards especially when heavy metals concentrations is concerned. Copyright © 2016 Elsevier Ltd. All rights reserved.
Stability and stabilisation of a class of networked dynamic systems

NASA Astrophysics Data System (ADS)

Liu, H. B.; Wang, D. Q.

2018-04-01

We investigate the stability and stabilisation of a linear time invariant networked heterogeneous system with arbitrarily connected subsystems. A new linear matrix inequality based sufficient and necessary condition for the stability is derived, based on which the stabilisation is provided. The obtained conditions efficiently utilise the block-diagonal characteristic of system parameter matrices and the sparseness of subsystem connection matrix. Moreover, a sufficient condition only dependent on each individual subsystem is also presented for the stabilisation of the networked systems with a large scale. Numerical simulations show that these conditions are computationally valid in the analysis and synthesis of a large-scale networked system.
Slipping Anchor? Testing the Vignettes Approach to Identification and Correction of Reporting Heterogeneity

PubMed Central

d’Uva, Teresa Bago; Lindeboom, Maarten; O’Donnell, Owen; van Doorslaer, Eddy

2011-01-01

We propose tests of the two assumptions under which anchoring vignettes identify heterogeneity in reporting of categorical evaluations. Systematic variation in the perceived difference between any two vignette states is sufficient to reject vignette equivalence. Response consistency - the respondent uses the same response scale to evaluate the vignette and herself – is testable given sufficiently comprehensive objective indicators that independently identify response scales. Both assumptions are rejected for reporting of cognitive and physical functioning in a sample of older English individuals, although a weaker test resting on less stringent assumptions does not reject response consistency for cognition. PMID:22184479
Information and consent in internet paternity testing: focus on minors' protection in Italy.

PubMed

Caenazzo, Luciana; Tozzo, Pamela; Benciolini, Paolo; Rodriguez, Daniele

2008-12-01

Paternity testing in Italy is usually performed by private laboratories and universities having direct contacts with the applicants. Recently, the number of paternity tests offered through laboratory websites has increased in Italy and Europe. The execution of genetic tests, including paternity testing based on DNA analysis, represents a complex act, which contains three main steps. Paternity analyses carried out by laboratories via Internet are performed on samples collected by the applicants and then mailed back to the laboratories without any patient-physician relationship. Information is given to the subjects through the laboratory's website or mailed with the test order form. The execution of "household" DNA analysis without technical precautions may provide an incorrect response with severe consequences on the individual who has undergone testing, on the family involved, and on society in general. The problems connected with this kind of analysis are not technical, but ethical and deontological. In this work, we will discuss the problems related to information and consent by way of outlining the relevant Italian laws and codes of medical ethics. The Italian Privacy's Guarantor is assessing the ethical and legal implications, but regulations are not yet in place. We believe that adequate information related to this practice cannot be given via Internet, and, consequently, the validity of the consent expressed during this kind of procedure can be uncertain. Further, we will analyze issues regarding the importance of minors' protection when a paternity test is performed via Internet. In our opinion, the complexity of the situations and expectations linked to paternity investigations require a special sensitivity in dealing with each case, based on a patient-physician relationship in the decision-making process especially referring to the defense of the minors' well-being.
Utilization of Genetic Testing Prior to Subspecialist Referral for Cerebellar Ataxia

PubMed Central

Fogel, Brent L.; Vickrey, Barbara G.; Walton-Wetzel, Jenny; Lieber, Eli

2013-01-01

Objective: To evaluate the utilization of laboratory testing in the diagnosis of cerebellar ataxia, including the completeness of initial standard testing for acquired causes, the early use of genetic testing, and associated clinical and nonclinical factors, among a cohort referred for subspecialty consultation. Methods: Data were abstracted from records of 95 consecutive ataxia patients referred to one neurogenetics subspecialist from 2006–2010 and linked to publicly available data on characteristics of referral clinicians. Multivariable logistic and linear regression models were used to analyze unique associations of clinical and nonclinical factors with laboratory investigation of acquired causes and with early genetic testing prior to referral. Results: At referral, 27 of 95 patients lacked evidence of any of 14 laboratory studies suggested for initial work-up of an acquired cause for ataxia (average number of tests=4.5). In contrast, 92% of patients had undergone brain magnetic resonance imaging prior to referral. Overall, 41.1% (n=39) had genetic testing prior to referral; there was no association between family history of ataxia and obtaining genetic testing prior to referral (p=0.39). The level of early genetic testing was 31.6%, primarily due to genetic testing despite an incomplete laboratory evaluation for acquired causes and no family history. A positive family history was consistently associated with less extensive laboratory testing (p=0.004), and referral by a neurologist was associated with higher levels of early genetic testing. Conclusions: Among consecutive referrals to a single center, a substantial proportion of sporadic cases had genetic testing without evidence of a work-up for acquired causes. Better strategies to guide decision making and subspecialty referrals in rare neurologic disorders are needed, given the cost and consequences of genetic testing. PMID:23725007
CALIBRATION OF FULL-SCALE OZONATION SYSTEMS WITH CONSERVATIVE AND REACTIVE TRACERS

EPA Science Inventory

A full-scale ozonation reactor was characterized with respect to the overall oxidation budget by coupling laboratory kinetics with reactor hydraulics. The ozone decomposition kinetics and the ratio of the OH radical to the ozone concentration were determined in laboratory batch ...
Size-density scaling in protists and the links between consumer-resource interaction parameters.

PubMed

DeLong, John P; Vasseur, David A

2012-11-01

Recent work indicates that the interaction between body-size-dependent demographic processes can generate macroecological patterns such as the scaling of population density with body size. In this study, we evaluate this possibility for grazing protists and also test whether demographic parameters in these models are correlated after controlling for body size. We compiled data on the body-size dependence of consumer-resource interactions and population density for heterotrophic protists grazing algae in laboratory studies. We then used nested dynamic models to predict both the height and slope of the scaling relationship between population density and body size for these protists. We also controlled for consumer size and assessed links between model parameters. Finally, we used the models and the parameter estimates to assess the individual- and population-level dependence of resource use on body-size and prey-size selection. The predicted size-density scaling for all models matched closely to the observed scaling, and the simplest model was sufficient to predict the pattern. Variation around the mean size-density scaling relationship may be generated by variation in prey productivity and area of capture, but residuals are relatively insensitive to variation in prey size selection. After controlling for body size, many consumer-resource interaction parameters were correlated, and a positive correlation between residual prey size selection and conversion efficiency neutralizes the apparent fitness advantage of taking large prey. Our results indicate that widespread community-level patterns can be explained with simple population models that apply consistently across a range of sizes. They also indicate that the parameter space governing the dynamics and the steady states in these systems is structured such that some parts of the parameter space are unlikely to represent real systems. Finally, predator-prey size ratios represent a kind of conundrum, because they are widely observed but apparently have little influence on population size and fitness, at least at this level of organization. © 2012 The Authors. Journal of Animal Ecology © 2012 British Ecological Society.
Review of the Need for a Large-scale Test Facility for Research on the Effects of Extreme Winds on Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

R. G. Little

1999-03-01

The Idaho National Engineering and Environmental Laboratory (INEEL), through the US Department of Energy (DOE), has proposed that a large-scale wind test facility (LSWTF) be constructed to study, in full-scale, the behavior of low-rise structures under simulated extreme wind conditions. To determine the need for, and potential benefits of, such a facility, the Idaho Operations Office of the DOE requested that the National Research Council (NRC) perform an independent assessment of the role and potential value of an LSWTF in the overall context of wind engineering research. The NRC established the Committee to Review the Need for a Large-scale Testmore » Facility for Research on the Effects of Extreme Winds on Structures, under the auspices of the Board on Infrastructure and the Constructed Environment, to perform this assessment. This report conveys the results of the committee's deliberations as well as its findings and recommendations. Data developed at large-scale would enhanced the understanding of how structures, particularly light-frame structures, are affected by extreme winds (e.g., hurricanes, tornadoes, sever thunderstorms, and other events). With a large-scale wind test facility, full-sized structures, such as site-built or manufactured housing and small commercial or industrial buildings, could be tested under a range of wind conditions in a controlled, repeatable environment. At this time, the US has no facility specifically constructed for this purpose. During the course of this study, the committee was confronted by three difficult questions: (1) does the lack of a facility equate to a need for the facility? (2) is need alone sufficient justification for the construction of a facility? and (3) would the benefits derived from information produced in an LSWTF justify the costs of producing that information? The committee's evaluation of the need and justification for an LSWTF was shaped by these realities.« less
[Actual state and problems in neurology training at graduate school].

PubMed

Kira, Jun-ichi; Ohyagi, Yasumasa; Taniwaki, Takayuki; Inuzuka, Takashi; Yoshii, Fumihito; Aoki, Masashi; Amano, Takahiro; Toyoshima, Itaru; Fukutake, Toshio; Hashimoto, Yoichiro

2014-01-01

To understand the status of postgraduate education in neurology in Japan, the Committee for the Education of Undergraduate Students and Junior Residents within the Japanese Society of Neurology investigated the four-year trend at 80 medical schools from 2009 to 2012. The mean number of new students to each postgraduate school increased from 1.24 to 1.67 during these four years. After training clinical neurology, more than half of the neurological residents entered the postgraduate schools. Students in the postgraduate schools seemed to be researching major neurological diseases using various methods at each neurology laboratory. However, some problems were suggested. First, the mean number of newcomers to the neurology departments of the universities decreased gradually from 2.29/year to 1.96/year. Second, many of the postgraduate students were working in patient services at university hospitals or as part-time workers at other hospitals, and may not have sufficient time for their research projects. Third, many of the postgraduate students were carrying out research at each affiliated department of neurology, and may not have the opportunity to work in laboratories specializing in basic science. Finally, there may not be sufficient opportunities for further research at other laboratories in Japan or overseas after they finished their work at postgraduate school.

Clinical Laboratories – Production Factories or Specialized Diagnostic Centers

PubMed Central

Tóth, Judit

2016-01-01

Since a large proportion of medical decisions are based on laboratory results, clinical laboratories should meet the increasing demand of clinicians and their patients. Huge central laboratories may process over 10 million tests annually; they act as production factories, measuring emergency and routine tests with sufficient speed and accuracy. At the same time, they also serve as specialized diagnostic centers where well-trained experts analyze and interpret special test results. It is essential to improve and constantly monitor this complex laboratory service, by several methods. Sample transport by pneumatic tube system, use of an advanced laboratory information system and point-of-care testing may result in decreased total turnaround time. The optimization of test ordering may result in a faster and more cost-effective laboratory service. Autovalidation can save time for laboratory specialists, when the analysis of more complex results requires their attention. Small teams of experts responsible for special diagnostic work, and their interpretative reporting according to predetermined principles, may help to minimize subjectivity of these special reports. Although laboratory investigations have become so diversely developed in the past decades, it is essential that the laboratory can provide accurate results relatively quickly, and that laboratory specialists can support the diagnosis and monitoring of patients by adequate interpretation of esoteric laboratory methods. PMID:27683528
‘A Most Protean Disease’: Aligning Medical Knowledge of Modern Influenza, 1890–1914

PubMed Central

Bresalier, Michael

2012-01-01

This article reconstructs the process of defining influenza as an infectious disease in the contexts of British medicine between 1890 and 1914. It shows how professional agreement on its nature and identity involved aligning different forms of knowledge produced in the field (public health), in the clinic (metropolitan hospitals) and in the laboratory (bacteriology). Two factors were crucial to this process: increasing trust in bacteriology and the organisation of large-scale collective investigations into influenza by Britain’s central public authority, the Medical Department of the Local Government Board. These investigations integrated epidemiological, clinical and bacteriological evidence into a new definition of influenza as a specific infection, in which a germ – Bacillus influenzae – was determined as playing a necessary but not sufficient role in its aetiology, transmission and pathogenesis. In defining ‘modern influenza’, bacteriological concepts and techniques were adapted to and selectively incorporated into existing clinical, pathological and epidemiological approaches. Mutual alignment thus was crucial to its construction and, more generally, to shaping developing relationships between laboratory, clinical and public health medicine in turn-of-the-century Britain. While these relationships were marked by tension and conflict, they were also characterised by important patterns of convergence, in which the problems, interests and practices of public health professionals, clinicians and laboratory pathologists were made increasingly commensurable. Rather than retrospectively judge the late nineteenth-century definition of influenza as being based on the wrong microbe, this article argues for the need to examine how it was established through a particular alignment of medical knowledge, which then underpinned medical approaches to the disease up to and beyond the devastating 1918–19 pandemic. PMID:23112382
Infusion phlebitis assessment measures: a systematic review

PubMed Central

Ray-Barruel, Gillian; Polit, Denise F; Murfield, Jenny E; Rickard, Claire M

2014-01-01

Rationale, aims and objectives Phlebitis is a common and painful complication of peripheral intravenous cannulation. The aim of this review was to identify the measures used in infusion phlebitis assessment and evaluate evidence regarding their reliability, validity, responsiveness and feasibility. Method We conducted a systematic literature review of the Cochrane library, Ovid MEDLINE and EBSCO CINAHL until September 2013. All English-language studies (randomized controlled trials, prospective cohort and cross-sectional) that used an infusion phlebitis scale were retrieved and analysed to determine which symptoms were included in each scale and how these were measured. We evaluated studies that reported testing the psychometric properties of phlebitis assessment scales using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines. Results Infusion phlebitis was the primary outcome measure in 233 studies. Fifty-three (23%) of these provided no actual definition of phlebitis. Of the 180 studies that reported measuring phlebitis incidence and/or severity, 101 (56%) used a scale and 79 (44%) used a definition alone. We identified 71 different phlebitis assessment scales. Three scales had undergone some psychometric analyses, but no scale had been rigorously tested. Conclusion Many phlebitis scales exist, but none has been thoroughly validated for use in clinical practice. A lack of consensus on phlebitis measures has likely contributed to disparities in reported phlebitis incidence, precluding meaningful comparison of phlebitis rates. PMID:24401116
Infusion phlebitis assessment measures: a systematic review.

PubMed

Ray-Barruel, Gillian; Polit, Denise F; Murfield, Jenny E; Rickard, Claire M

2014-04-01

Phlebitis is a common and painful complication of peripheral intravenous cannulation. The aim of this review was to identify the measures used in infusion phlebitis assessment and evaluate evidence regarding their reliability, validity, responsiveness and feasibility. We conducted a systematic literature review of the Cochrane library, Ovid MEDLINE and EBSCO CINAHL until September 2013. All English-language studies (randomized controlled trials, prospective cohort and cross-sectional) that used an infusion phlebitis scale were retrieved and analysed to determine which symptoms were included in each scale and how these were measured. We evaluated studies that reported testing the psychometric properties of phlebitis assessment scales using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines. Infusion phlebitis was the primary outcome measure in 233 studies. Fifty-three (23%) of these provided no actual definition of phlebitis. Of the 180 studies that reported measuring phlebitis incidence and/or severity, 101 (56%) used a scale and 79 (44%) used a definition alone. We identified 71 different phlebitis assessment scales. Three scales had undergone some psychometric analyses, but no scale had been rigorously tested. Many phlebitis scales exist, but none has been thoroughly validated for use in clinical practice. A lack of consensus on phlebitis measures has likely contributed to disparities in reported phlebitis incidence, precluding meaningful comparison of phlebitis rates. © 2014 The Authors. Journal of Evaluation in Clinical Practice published by John Wiley & Sons, Ltd.
The laboratory curse: variation in temperature stimulates embryonic development and shortens diapause

USDA-ARS?s Scientific Manuscript database

An ongoing biological debate is the difference in trait expression in continuous versus cycling temperature regimes, but are even daily cycling temperatures sufficient to generate natural expression of traits? We compared embryonic development and the duration of diapause for Mormon cricket eggs in...
21 CFR 660.4 - Potency test.

Code of Federal Regulations, 2012 CFR

2012-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.4 Potency test. To be satisfactory for release, each filling of Antibody to Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Surface Antigen Panel and shall be sufficiently potent...
21 CFR 660.4 - Potency test.

Code of Federal Regulations, 2011 CFR

2011-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.4 Potency test. To be satisfactory for release, each filling of Antibody to Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Surface Antigen Panel and shall be sufficiently potent...
21 CFR 660.43 - Potency test.

Code of Federal Regulations, 2014 CFR

2014-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.43 Potency test. To be satisfactory for release, each filling of Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Antiserum Panel and shall be sufficiently potent to be able to detect the...
21 CFR 660.43 - Potency test.

Code of Federal Regulations, 2011 CFR

2011-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.43 Potency test. To be satisfactory for release, each filling of Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Antiserum Panel and shall be sufficiently potent to be able to detect the...
21 CFR 660.4 - Potency test.

Code of Federal Regulations, 2014 CFR

2014-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.4 Potency test. To be satisfactory for release, each filling of Antibody to Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Surface Antigen Panel and shall be sufficiently potent...
21 CFR 660.43 - Potency test.

Code of Federal Regulations, 2012 CFR

2012-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.43 Potency test. To be satisfactory for release, each filling of Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Antiserum Panel and shall be sufficiently potent to be able to detect the...
21 CFR 660.4 - Potency test.

Code of Federal Regulations, 2010 CFR

2010-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Antibody to Hepatitis B Surface Antigen § 660.4 Potency test. To be satisfactory for release, each filling of Antibody to Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Surface Antigen Panel and shall be sufficiently potent...
21 CFR 660.43 - Potency test.

Code of Federal Regulations, 2010 CFR

2010-04-01

... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.43 Potency test. To be satisfactory for release, each filling of Hepatitis B Surface Antigen shall be tested against the Reference Hepatitis B Antiserum Panel and shall be sufficiently potent to be able to detect the...
The physics of rainclouds, what is behind rainfall trends?

NASA Astrophysics Data System (ADS)

Junkermann, Wolfgang; Hacker, Jorg

2017-04-01

In several locations in the world rainfall was significantly declining during the last four decades since about 1970, despite during the same timespan the water vapor availability in the planetary boundary layer (PBL) was increasing by about five percent. Increasing water vapor levels in the PBL are a result of climate change and well in agreement with the observed one degree increase of air temperature over the oceans. Increasing water vapor availability due to an increase in evaporation should lead to a higher turnover rate within the hydrological cycle, which should result either in more frequent or in more intense rainfall. Several regional observations especially along the Australian coastline show a contrary picture. Often rainfall is less frequent and the annual rainfall is declining. Also the number of rainy days goes down. This behavior could be caused by a number of different processes affecting both, the amount of liquid water in the atmosphere and the microphysical properties of clouds. Within the discussions are: -A change in the large scale advection patterns due to global warming, shifting the trajectories of low pressure systems, a slow process that takes several decades. -A change in land use by deforestation leading to lower roughness, higher albedo and lower convective energy. Such a land use change might happen within about one decade (e.g. Western Australia). -A change in aerosol abundance. Addition of anthropogenic cloud condensation nuclei lead instantly to smaller cloud droplets and subsequently to a regional to continental scale redistribution of rainfall within the time scales of cloud lifetime (hours to days). Airborne experiments show that indeed the number of aerosols in several of the respective areas investigated up to now was increasing roughly in time with the observed rainfall changes. However, only in few of the areas the availability of historical aerosol data is sufficient for a more detailed investigation. We show results from experiments in search for physical reasons for a regional scale rainfall decline observed along the Australian coastline. Here the historical database including an airborne survey in the early 70's allows to reconstruct a 'laboratory' notebook an aerosol trends. This makes the area a perfect 'natural laboratory' for such studies on the physical background for climate change trends and to disentangle different climate / hydrological cycle relevant physical processes.
DEVELOPMENT OF DEWATERING AIDS FOR MINERALS AND COAL FINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roe-Hoam Yoon; Ramazan Asmatulu; Ismail Yildirim

2004-07-01

MCT has developed a suite of novel dewatering chemicals (or aids) that are designed to cause a decrease in the capillary pressures of the water trapped in a filter cake by (1) decreasing the surface tension of water, (2) increasing the contact angles of the particles to be dewatered, and (3) causing the particles to coagulate, all at the same time. The decrease in capillary pressure in turn causes an increase in the rate filtration, an increase in throughput, and a decrease in pressure drop requirement for filtration. The reagents are used frequently as blends of different chemicals in ordermore » to bring about the changes in all of the process variables noted above. The minerals and coal samples tested in the present work included copper sulfide, lead sulfide, zinc sulfide, kaolin clay, talc, and silica. The laboratory-scale test work included studies of reagent types, drying cycle times, cake thickness, slurry temperature, conditioning intensity and time, solid content, and reagent dosages. To better understand the mechanisms involved, fundamental studies were also conducted. These included the measurements of the contact angles of the particles to be dewatered (which are the measures of particle hydrophobicity) and the surface tensions of the filtrates produced from dewatering tests. The results of the laboratory-scale filtration experiments showed that the use of the novel dewatering aids can reduce the moistures of the filter cake by 30 to 50% over what can be achieved using no dewatering aids. In many cases, such high levels of moisture reductions are sufficient to obviate the needs for thermal drying, which is costly and energy intensive. Furthermore, the use of the novel dewatering aids cause a substantial increase in the kinetics of dewatering, which in turn results in increased throughput. As a result of these technological advantages, the novel dewatering aids have been licensed to Nalco, which is one of the largest mining chemicals companies of the world. At least one mineral company is currently using the technology in full-scale plant operation, which has resulted in the shutdown of a thermal dryer.« less
Neighborhood scale quantification of ecosystem goods and ...

EPA Pesticide Factsheets

Ecosystem goods and services are those ecological structures and functions that humans can directly relate to their state of well-being. Ecosystem goods and services include, but are not limited to, a sufficient fresh water supply, fertile lands to produce agricultural products, shading, air and water of sufficient quality for designated uses, flood water retention, and places to recreate. The US Environmental Protection Agency (USEPA) Office of Research and Development’s Tampa Bay Ecosystem Services Demonstration Project (TBESDP) modeling efforts organized existing literature values for biophysical attributes and processes related to EGS. The goal was to develop a database for informing mapped-based EGS assessments for current and future land cover/use scenarios at multiple scales. This report serves as a demonstration of applying an EGS assessment approach at the large neighborhood scale (~1,000 acres of residential parcels plus common areas). Here, we present mapped inventories of ecosystem goods and services production at a neighborhood scale within the Tampa Bay, FL region. Comparisons of the inventory between two alternative neighborhood designs are presented as an example of how one might apply EGS concepts at this scale.
Detection of designer drugs in human hair by ion mobility spectrometry (IMS).

PubMed

Keller, T; Miki, A; Regenscheit, P; Dirnhofer, R; Schneider, A; Tsuchihashi, H

1998-06-08

Since its inception in the early 1970s under the name plasma chromatography, ion mobility spectrometry (IMS) has undergone great changes. It is now utilized more and more in forensic science laboratories where it is used to detect explosives and environmental pollutants [1-4] as well as its use in detecting drugs of abuse [5-8]. Although IMS is known for nearly 30 years now [9], relatively few cases of the application of ion mobility spectrometry to the analysis of human hair have been reported [10-12]. The authors report a new and quick method to rapidly screen and determine MDMA ('ecstasy', 'Adam') and MDEA ('Eve') in human hair. The proposed method using trihexylamine as internal standard resulted in a rapid procedure useful in screening human hair specimens for designer drugs.
Chapter 1.1 Process Scale-Up of Cellulose Nanocrystal Production to 25 kg per Batch at the Forest Products Laboratory

Treesearch

Richard S. Reiner; Alan W. Rudie

2013-01-01

The Fiber and Chemical Sciences Research Work Unit at the Forest Products Laboratory began working out the preparation of cellulose nanocrystals in 2006, using the method of Dong, Revol, and Gray. Initial samples were provided to several scientists within the Forest Service. Continued requests for this material forced scale-up from the initial 20 g scale to kg...
Pilot-scale production of fuel ethanol from concentrated food waste hydrolysates using Saccharomyces cerevisiae H058.

PubMed

Yan, Shoubao; Chen, Xiangsong; Wu, Jingyong; Wang, Pingchao

2013-07-01

The aim of this study was to develop a bioprocess to produce ethanol from food waste at laboratory, semipilot and pilot scales. Laboratory tests demonstrated that ethanol fermentation with reducing sugar concentration of 200 g/L, inoculum size of 2 % (Initial cell number was 2 × 10⁶ CFU/mL) and addition of YEP (3 g/L of yeast extract and 5 g/L of peptone) was the best choice. The maximum ethanol concentration in laboratory scale (93.86 ± 1.15 g/L) was in satisfactory with semipilot scale (93.79 ± 1.11 g/L), but lower than that (96.46 ± 1.12 g/L) of pilot-scale. Similar ethanol yield and volumetric ethanol productivity of 0.47 ± 0.02 g/g, 1.56 ± 0.03 g/L/h and 0.47 ± 0.03 g/g, 1.56 ± 0.03 g/L/h after 60 h of fermentation in laboratory and semipilot fermentors, respectively, however, both were lower than that (0.48 ± 0.02 g/g, 1.79 ± 0.03 g/L/h) of pilot reactor. In addition, simple models were developed to predict the fermentation kinetics during the scale-up process and they were successfully applied to simulate experimental results.
Predicting the performance uncertainty of a 1-MW pilot-scale carbon capture system after hierarchical laboratory-scale calibration and validation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Zhijie; Lai, Canhai; Marcy, Peter William

2017-05-01

A challenging problem in designing pilot-scale carbon capture systems is to predict, with uncertainty, the adsorber performance and capture efficiency under various operating conditions where no direct experimental data exist. Motivated by this challenge, we previously proposed a hierarchical framework in which relevant parameters of physical models were sequentially calibrated from different laboratory-scale carbon capture unit (C2U) experiments. Specifically, three models of increasing complexity were identified based on the fundamental physical and chemical processes of the sorbent-based carbon capture technology. Results from the corresponding laboratory experiments were used to statistically calibrate the physical model parameters while quantifying some of theirmore » inherent uncertainty. The parameter distributions obtained from laboratory-scale C2U calibration runs are used in this study to facilitate prediction at a larger scale where no corresponding experimental results are available. In this paper, we first describe the multiphase reactive flow model for a sorbent-based 1-MW carbon capture system then analyze results from an ensemble of simulations with the upscaled model. The simulation results are used to quantify uncertainty regarding the design’s predicted efficiency in carbon capture. In particular, we determine the minimum gas flow rate necessary to achieve 90% capture efficiency with 95% confidence.« less

Beam tracking phase tomography with laboratory sources

NASA Astrophysics Data System (ADS)

Vittoria, F. A.; Endrizzi, M.; Kallon, G. K. N.; Hagen, C. K.; Diemoz, P. C.; Zamir, A.; Olivo, A.

2018-04-01

An X-ray phase-contrast laboratory system is presented, based on the beam-tracking method. Beam-tracking relies on creating micro-beamlets of radiation by placing a structured mask before the sample, and analysing them by using a detector with sufficient resolution. The system is used in tomographic configuration to measure the three dimensional distribution of the linear attenuation coefficient, difference from unity of the real part of the refractive index, and of the local scattering power of specimens. The complementarity of the three signals is investigated, together with their potential use for material discrimination.
SIMILARITY PROPERTIES AND SCALING LAWS OF RADIATION HYDRODYNAMIC FLOWS IN LABORATORY ASTROPHYSICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Falize, E.; Bouquet, S.; Michaut, C., E-mail: emeric.falize@cea.fr

The spectacular recent development of modern high-energy density laboratory facilities which concentrate more and more energy in millimetric volumes allows the astrophysical community to reproduce and to explore, in millimeter-scale targets and during very short times, astrophysical phenomena where radiation and matter are strongly coupled. The astrophysical relevance of these experiments can be checked from the similarity properties and especially scaling law establishment, which constitutes the keystone of laboratory astrophysics. From the radiating optically thin regime to the so-called optically thick radiative pressure regime, we present in this paper, for the first time, a complete analysis of the main radiatingmore » regimes that we encountered in laboratory astrophysics with the same formalism based on Lie group theory. The use of the Lie group method appears to be a systematic method which allows us to construct easily and systematically the scaling laws of a given problem. This powerful tool permits us to unify the recent major advances on scaling laws and to identify new similarity concepts that we discuss in this paper, and suggests important applications for present and future laboratory astrophysics experiments. All these results enable us to demonstrate theoretically that astrophysical phenomena in such radiating regimes can be explored experimentally thanks to powerful facilities. Consequently, the results presented here are a fundamental tool for the high-energy density laboratory astrophysics community in order to quantify the astrophysics relevance and justify laser experiments. Moreover, relying on Lie group theory, this paper constitutes the starting point of any analysis of the self-similar dynamics of radiating fluids.« less
Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis.

PubMed

Browning, Douglas F; Wells, Timothy J; França, Fernanda L S; Morris, Faye C; Sevastsyanovich, Yanina R; Bryant, Jack A; Johnson, Matthew D; Lund, Peter A; Cunningham, Adam F; Hobman, Jon L; May, Robin C; Webber, Mark A; Henderson, Ian R

2013-03-01

Escherichia coli has been the leading model organism for many decades. It is a fundamental player in modern biology, facilitating the molecular biology revolution of the last century. The acceptance of E. coli as model organism is predicated primarily on the study of one E. coli lineage; E. coli K-12. However, the antecedents of today's laboratory strains have undergone extensive mutagenesis to create genetically tractable offspring but which resulted in loss of several genetic traits such as O antigen expression. Here we have repaired the wbbL locus, restoring the ability of E. coli K-12 strain MG1655 to express the O antigen. We demonstrate that O antigen production results in drastic alterations of many phenotypes and the density of the O antigen is critical for the observed phenotypes. Importantly, O antigen production enables laboratory strains of E. coli to enter the gut of the Caenorhabditis elegans worm and to kill C. elegans at rates similar to pathogenic bacterial species. We demonstrate C. elegans killing is a feature of other commensal E. coli. We show killing is associated with bacterial resistance to mechanical shear and persistence in the C. elegans gut. These results suggest C. elegans is not an effective model of human-pathogenic E. coli infectious disease. © 2013 Blackwell Publishing Ltd.
Relevance of multiple spatial scales in habitat models: A case study with amphibians and grasshoppers

NASA Astrophysics Data System (ADS)

Altmoos, Michael; Henle, Klaus

2010-11-01

Habitat models for animal species are important tools in conservation planning. We assessed the need to consider several scales in a case study for three amphibian and two grasshopper species in the post-mining landscapes near Leipzig (Germany). The two species groups were selected because habitat analyses for grasshoppers are usually conducted on one scale only whereas amphibians are thought to depend on more than one spatial scale. First, we analysed how the preference to single habitat variables changed across nested scales. Most environmental variables were only significant for a habitat model on one or two scales, with the smallest scale being particularly important. On larger scales, other variables became significant, which cannot be recognized on lower scales. Similar preferences across scales occurred in only 13 out of 79 cases and in 3 out of 79 cases the preference and avoidance for the same variable were even reversed among scales. Second, we developed habitat models by using a logistic regression on every scale and for all combinations of scales and analysed how the quality of habitat models changed with the scales considered. To achieve a sufficient accuracy of the habitat models with a minimum number of variables, at least two scales were required for all species except for Bufo viridis, for which a single scale, the microscale, was sufficient. Only for the European tree frog ( Hyla arborea), at least three scales were required. The results indicate that the quality of habitat models increases with the number of surveyed variables and with the number of scales, but costs increase too. Searching for simplifications in multi-scaled habitat models, we suggest that 2 or 3 scales should be a suitable trade-off, when attempting to define a suitable microscale.
Normative scores on the Berg Balance Scale decline after age 70 years in healthy community-dwelling people: a systematic review.

PubMed

Downs, Stephen; Marquez, Jodie; Chiarelli, Pauline

2014-06-01

What is the mean Berg Balance Scale score of healthy elderly people living in the community and how does it vary with age? How much variability in Berg Balance Scale scores is present in groups of healthy elderly people and how does this vary with age? Systematic review with meta-analysis. Any group of healthy community-dwelling people with a mean age of 70 years or greater that has undergone assessment using the Berg Balance Scale. Mean and standard deviations of Berg Balance Scale scores within cohorts of elderly people of known mean age. The search yielded 17 relevant studies contributing data from a total of 1363 participants. The mean Berg Balance Scale scores ranged from 37 to 55 out of a possible maximum score of 56. The standard deviation of Berg Balance Scale scores varied from 1.0 to 9.2. Although participants aged around 70 years had very close to normal Berg Balance Scale scores, there was a significant decline in balance with age at a rate of 0.7 points on the 56-point Berg Balance Scale per year. There was also a strong association between increasing age and increasing variability in balance (R(2) = 0.56, p < 0.001). Healthy community-dwelling elderly people have modest balance deficits, as measured by the Berg Balance Scale, although balance scores deteriorate and become more variable with age. Copyright © 2014. Published by Elsevier B.V.
The Impact of Deep Brain Stimulation on the Quality of Life and Swallowing in Individuals with Parkinson's Disease

PubMed Central

Olchik, Maira Rozenfel; Ghisi, Marciéle; Ayres, Annelise; Schuh, Arthur Francisco Shumacher; Oppitz, Paulo Petry; Rieder, Carlos Roberto de Mello

2018-01-01

Introduction Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD). However, there is little evidence regarding the effect of DBS on dysphagia. Objective To assess the swallowing and quality of life of individuals with PD before and after DBS surgery. Methods Our sample consisted of people who had undergone DBS surgery in a referral hospital in the state of Rio Grande do Sul, Brazil. The inclusion criteria were a diagnosis of PD and having undergone DBS surgery. A cognitive screening, through a questionnaire about depression and quality of life, was conducted. Evaluations of each patient's swallowing were performed before and after surgery. The assessment consisted of anamnesis, clinical assessment, the Functional Oral Intake Scale, clinical evaluation of swallowing, and the Hoehn and Yahr scale. Results The sample included 10 individuals, all male, with a mean age of 57.3 years (±4.7), a mean disease duration of 13.0 years (±2.4), and mean level education of 8.1 years (±4.0). In the clinical evaluation of the swallowing, a significant improvement after DBS was not observed. However, little changes in the signs and symptoms of dysphagia that had a positive impact on the quality of life were observed. Furthermore, there was no relation between the patients' motor subtype and swallowing pre- and post-DBS. Conclusion There was an improvement in the quality of life of the patients after DBS. However, the improvement in the clinical signs and symptoms of dysphagia did not cause an overall improvement in the swallowing function. PMID:29619099
Subtalar Coalitions: Does the Morphology of the Subtalar Joint Involvement Influence Outcomes After Coalition Excision?

PubMed

Mahan, Susan T; Prete, Victoria I; Spencer, Samantha A; Kasser, James R; Bixby, Sarah D

Posteromedial subtalar (PMST) coalitions are a recently described anatomic subtype of tarsal coalitions. We compared with clinical patient-based outcomes of patients with PMST and standard middle facet (MF) coalitions who had undergone surgical excision of their coalition. The included patients had undergone surgical excision of a subtalar tarsal coalition, preoperative computed tomography (CT), and patient-based outcomes measures after surgery (including the American Orthopaedic Foot and Ankle Society [AOFAS] scale and University of California, Los Angeles [UCLA], activity score). Blinded analysis of the preoperative CT scan findings determined the presence of a standard MF versus a PMST coalition. The perioperative factors and postoperative outcomes between the MF and PMST coalitions were compared. A total of 51 feet (36 patients) were included. The mean follow-up duration was 2.6 years after surgery. Of the 51 feet, 15 (29.4%) had a PMST coalition and 36 (70.6%) had an MF coalition. No difference was found in the UCLA activity score; however, the mean AOFAS scale score was higher for patients with PMST (95.7) than for those with MF (86.5; p = .018). Of the patients with a PMST, none had foot pain limiting their activities at the final clinical follow-up visit. However, in the group with an MF subtalar coalition, 10 (27.8%) had ongoing foot pain limiting activity at the final follow-up visit (p = .024). Compared with MF subtalar tarsal coalitions, patients with PMST coalitions showed significantly improved clinical outcomes after excision. Preoperative identification of the facet morphology can improve patient counseling and expectations after surgery. Copyright © 2017 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
Assessment of three medical and research laboratories using WHO AFRO_SLIPTA Quality Standards in Southwestern Uganda: a long way to go.

PubMed

Taremwa, Ivan Mugisha; Ampaire, Lucas; Iramiot, Jacob; Muhwezi, Obed; Matte, Aloysius; Itabangi, Herbert; Mbabazi, Hope; Atwebembeire, Jeninah; Kamwine, Monicah; Katawera, Victoria; Mbalibulha, Yona; Orikiriza, Patrick; Boum, Yap

2017-01-01

While the laboratory represents more than 70% of clinical diagnosis and patient management, access to reliable and quality laboratory diagnostics in sub-Saharan Africa remains a challenge. To gain knowledge and suggest evidence based interventions towards laboratory improvement in Southwestern Uganda, we assessed the baseline laboratory quality standards in three medical and research laboratories in Southwestern Uganda. We conducted a cross sectional survey from October, 2013 to April, 2014. Selected laboratories, including one private research, one private for profit and one public laboratory, were assessed using the WHO AFRO_SLIPTA checklist and baseline scores were determined. The three laboratories assessed met basic facility requirements, had trained personnel, and safety measures in place. Sample reception was properly designed and executed with a well designated chain of custody. All laboratories had sufficient equipment for the nature of work they were involved in. However, we found that standard operating procedures were incomplete in all three laboratories, lack of quality audit schemes by two laboratories and only one laboratory enrolled into external quality assurance schemes. The SLIPTA scores were one star for the research laboratory and no star for both the public and private-for-profit laboratories. While most of the laboratory systems were in place, the low scores obtained by the assessed laboratories reflect the need for improvement to reach standards of quality assured diagnostics in the region. Therefore, routine mentorship and regional supportive supervision are necessary to increase the quality of laboratory services.
Application of laboratory permeability data

USGS Publications Warehouse

Johnson, A.I.

1963-01-01

Some of the basic material contained in this report originally was prepared in 1952 as instructional handouts for ground-water short courses and for training of foreign participants. The material has been revised and expanded and is presented in the present form to make it more readily available to the field hydrologist. Illustrations now present published examples of the applications suggested in the 1952 material. For small areas, a field pumping test is sufficient to predict the characteristics of an aquifer. With a large area under study, the aquifer properties must be determined at many different locations and it is not usually economically feasible to make sufficient field tests to define the aquifer properties in detail for the whole aquifer. By supplementing a few field tests with laboratory permeability data and geologic interpretation, more point measurements representative of the hydrologic properties of the aquifer may be obtained. A sufficient number of samples seldom can be obtained to completely identify the permeability or transmissibility in detail for a project area. However, a few judiciously chosen samples of high quality, combined with good geologic interpretation, often will permit the extrapolation of permeability information over a large area with a fair degree of reliability. The importance of adequate geologic information, as well as the importance of collecting samples representative of at least all major textural units lying within the section or area of study, cannot be overemphasized.
Laboratory and Pilot Scale Evaluation of Coagulation, Clarification, and Filtration for Upgrading Sewage Lagoon Effluents.

DTIC Science & Technology

1980-08-01

AD-AGAB 906 ARMY ENGINEER WATERWAYS EXPERIMENT STATION VICKSBURG--ETC FIG 14/2 LABORATORY AND PILOT SCALE EVALUATION OF COAGULATION, CLARIFICA -ETC U...FILTRATION FOR LWGRADING JEWAGE LAGOON EFFLUENTS~ w IL j0 ( M John ullinane, Jr., Richard A. hafer (0 Environmental Laboratory gel U. S. Army Engineer ...Shafer 9. PERFORMING ORGANIZATION NAME AND ADORESS SO. PROGRAM ELEMENT, PROJECT, TASK AREA a WORK UNIT NUMBERS U. S. Army Engineer Waterways Experiment
Early‐Stage Capital Cost Estimation of Biorefinery Processes: A Comparative Study of Heuristic Techniques

PubMed Central

Couturier, Jean‐Luc; Kokossis, Antonis; Dubois, Jean‐Luc

2016-01-01

Abstract Biorefineries offer a promising alternative to fossil‐based processing industries and have undergone rapid development in recent years. Limited financial resources and stringent company budgets necessitate quick capital estimation of pioneering biorefinery projects at the early stages of their conception to screen process alternatives, decide on project viability, and allocate resources to the most promising cases. Biorefineries are capital‐intensive projects that involve state‐of‐the‐art technologies for which there is no prior experience or sufficient historical data. This work reviews existing rapid cost estimation practices, which can be used by researchers with no previous cost estimating experience. It also comprises a comparative study of six cost methods on three well‐documented biorefinery processes to evaluate their accuracy and precision. The results illustrate discrepancies among the methods because their extrapolation on biorefinery data often violates inherent assumptions. This study recommends the most appropriate rapid cost methods and urges the development of an improved early‐stage capital cost estimation tool suitable for biorefinery processes. PMID:27484398
Pressure induced phase transitions in ceramic compounds containing tetragonal zirconia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sparks, R.G.; Pfeiffer, G.; Paesler, M.A.

Stabilized tetragonal zirconia compounds exhibit a transformation toughening process in which stress applied to the material induces a crystallographic phase transition. The phase transition is accompanied by a volume expansion in the stressed region thereby dissipating stress and increasing the fracture strength of the material. The hydrostatic component of the stress required to induce the phase transition can be investigated by the use of a high pressure technique in combination with Micro-Raman spectroscopy. The intensity of Raman lines characteristic for the crystallographic phases can be used to calculate the amount of material that has undergone the transition as a functionmore » of pressure. It was found that pressures on the order of 2-5 kBar were sufficient to produce an almost complete transition from the original tetragonal to the less dense monoclinic phase; while a further increase in pressure caused a gradual reversal of the transition back to the original tetragonal structure.« less
Lithology, reservoir properties, and burial history of portion of Gammon Shale ( Cretaceous), southwestern North Dakota.

USGS Publications Warehouse

Gautier, D.L.

1981-01-01

In the northern Great Plains, large quantities of biogenic methane are contained at shallow depths in Cretaceous marine mudstones. The Gammon Shale and equivalents of the Milk River Formation in Canada are typical. At Little Missouri field, Gammon reservoirs consist of discontinuous lenses and laminae of siltstone, enclosed by silty clay shale. Large amounts of allogenic clay, including highly expansible mixed-layer illite-smectite cause great water sensitivity and high water-saturation values. Studies show that the Gammon has not undergone thermal conditions sufficient for oil or thermal gas generation. The scarcity of authigenic silicates suggests that diagenesis has been inhibited by the presence of free methane. Shale layers are practically impermeable whereas siltstone microlenses are porous (30-40%) and have permeabilities on the order of 3-30 md. Organic matter in the low-permeability reservoirs served as the source of biogenic methane, and capillary forces acted as the trapping mechanism for gas accumulation. Much of the Gammon interval is potentially economic. -from Author
Fluid dynamics structures in a fire environment observed in laboratory-scale experiments

Treesearch

J. Lozano; W. Tachajapong; D.R. Weise; S. Mahalingam; M. Princevac

2010-01-01

Particle Image Velocimetry (PIV) measurements were performed in laboratory-scale experimental fires spreading across horizontal fuel beds composed of aspen (Populus tremuloides Michx) excelsior. The continuous flame, intermittent flame, and thermal plume regions of a fire were investigated. Utilizing a PIV system, instantaneous velocity fields for...
Regeneration of Exhausted Arsenic Adsorptive media of a Full Scale Treatment System

EPA Science Inventory

This presentation will describe the method and results of laboratory tests showing the feasibility of regenerating exhausted, iron-based, adsorptive media and the results of a follow up regeneration test at a full scale system in Twentynine Palms CA. The laboratory studies on se...
Towards a better understanding of the cracking behavior in soils

USDA-ARS?s Scientific Manuscript database

Understanding and modeling shrinkage-induced cracks helps bridge the gap between flow problem in the laboratory and at the field. Modeling flow at the field scale with Darcian fluxes developed at the laboratory scales is challenged with preferential flows attributed to the cracking behavior of soils...
Fate of estrone in laboratory-scale constructed wetlands

USDA-ARS?s Scientific Manuscript database

A horizontal, subsurface, laboratory-scale constructed wetland (CW) consisting of four cells in series was used to determine the attenuation of the steroid hormone estrone (E1) present in animal wastewater. Liquid swine manure diluted 1:80 with farm pond water and dosed with [14C]E1 flowed through ...
Fate of the antibiotic sulfadiazine in natural soils: Experimental and numerical investigations.

PubMed

Engelhardt, Irina; Sittig, Stephan; Šimůnek, Jirka; Groeneweg, Joost; Pütz, Thomas; Vereecken, Harry

2015-01-01

Based on small-scale laboratory and field-scale lysimeter experiments, the sorption and biodegradation of sulfonamide sulfadiazine (SDZ) were investigated in unsaturated sandy and silty-clay soils. Sorption and biodegradation were low in the laboratory, while the highest leaching rates were observed when SDZ was mixed with manure. The leaching rate decreased when SDZ was mixed with pure water, and was smallest with the highest SDZ concentrations. In the laboratory, three transformation products (TPs) developed after an initial lag phase. However, the amount of TPs was different for different mixing-scenarios. The TP 2-aminopyrimidine was not observed in the laboratory, but was the most prevalent TP at the field scale. Sorption was within the same range at the laboratory and field scales. However, distinctive differences occurred with respect to biodegradation, which was higher in the field lysimeters than at the laboratory scale. While the silty-clay soil favored sorption of SDZ, the sandy, and thus highly permeable, soil was characterized by short half-lives and thus a quick biodegradation of SDZ. For 2-aminopyrimidine, half-lives of only a few days were observed. Increased field-scale biodegradation in the sandy soil resulted from a higher water and air permeability that enhanced oxygen transport and limited oxygen depletion. Furthermore, low pH was more important than the organic matter and clay content for increasing the biodegradation of SDZ. A numerical analysis of breakthrough curves of bromide, SDZ, and its TPs showed that preferential flow pathways strongly affected the solute transport within shallow parts of the soil profile at the field scale. However, this effect was reduced in deeper parts of the soil profile. Due to high field-scale biodegradation in several layers of both soils, neither SDZ nor 2-aminopyrimidine was detected in the discharge of the lysimeter at a depth of 1m. Synthetic 50 year long simulations, which considered the application of manure with SDZ for general agricultural practices in Germany and humid climate conditions, showed that the concentration of SDZ decreased below 0.1 μg/L in both soils below the depth of 50 cm. Copyright © 2015 Elsevier B.V. All rights reserved.
Fate of the antibiotic sulfadiazine in natural soils: Experimental and numerical investigations

NASA Astrophysics Data System (ADS)

Engelhardt, Irina; Sittig, Stephan; Šimůnek, Jirka; Groeneweg, Joost; Pütz, Thomas; Vereecken, Harry

2015-06-01

Based on small-scale laboratory and field-scale lysimeter experiments, the sorption and biodegradation of sulfonamide sulfadiazine (SDZ) were investigated in unsaturated sandy and silty-clay soils. Sorption and biodegradation were low in the laboratory, while the highest leaching rates were observed when SDZ was mixed with manure. The leaching rate decreased when SDZ was mixed with pure water, and was smallest with the highest SDZ concentrations. In the laboratory, three transformation products (TPs) developed after an initial lag phase. However, the amount of TPs was different for different mixing-scenarios. The TP 2-aminopyrimidine was not observed in the laboratory, but was the most prevalent TP at the field scale. Sorption was within the same range at the laboratory and field scales. However, distinctive differences occurred with respect to biodegradation, which was higher in the field lysimeters than at the laboratory scale. While the silty-clay soil favored sorption of SDZ, the sandy, and thus highly permeable, soil was characterized by short half-lives and thus a quick biodegradation of SDZ. For 2-aminopyrimidine, half-lives of only a few days were observed. Increased field-scale biodegradation in the sandy soil resulted from a higher water and air permeability that enhanced oxygen transport and limited oxygen depletion. Furthermore, low pH was more important than the organic matter and clay content for increasing the biodegradation of SDZ. A numerical analysis of breakthrough curves of bromide, SDZ, and its TPs showed that preferential flow pathways strongly affected the solute transport within shallow parts of the soil profile at the field scale. However, this effect was reduced in deeper parts of the soil profile. Due to high field-scale biodegradation in several layers of both soils, neither SDZ nor 2-aminopyrimidine was detected in the discharge of the lysimeter at a depth of 1 m. Synthetic 50 year long simulations, which considered the application of manure with SDZ for general agricultural practices in Germany and humid climate conditions, showed that the concentration of SDZ decreased below 0.1 μg/L in both soils below the depth of 50 cm.
Interactive toxicity of major ion salts: Comparisons among species and between acute and chronic endpoints

EPA Science Inventory

Increased concentrations of major ions (Na, K, Ca, Mg, Cl, SO4, HCO3) in freshwater systems can result from a variety of anthropogenic activities, and can adversely affect aquatic organisms if the increase is sufficiently severe. Laboratory tests have indicated that the toxicity...

Manpower Requirements Report for FY (Fiscal Year) 1984.

DTIC Science & Technology

1983-02-01

capability to detect cannabis brings to seven the number of drugs detectable through urinaly- sis in the DoD system. While the detection and deterrence of... toxicology . The primary purpose of these con- ferences was validation of Legal sufficiency of the DoD laboratory system by the scientific community
Evaluating a Technology Supported Interactive Response System during the Laboratory Section of a Histology Course

ERIC Educational Resources Information Center

Rinaldi, Vera D.; Lorr, Nancy A.; Williams, Kimberly

2017-01-01

Monitoring of student learning through systematic formative assessment is important for adjusting pedagogical strategies. However, traditional formative assessments, such as quizzes and written assignments, may not be sufficiently timely for making adjustments to a learning process. Technology supported formative assessment tools assess student…
Microarrays for Undergraduate Classes

ERIC Educational Resources Information Center

Hancock, Dale; Nguyen, Lisa L.; Denyer, Gareth S.; Johnston, Jill M.

2006-01-01

A microarray experiment is presented that, in six laboratory sessions, takes undergraduate students from the tissue sample right through to data analysis. The model chosen, the murine erythroleukemia cell line, can be easily cultured in sufficient quantities for class use. Large changes in gene expression can be induced in these cells by…
Statistical Analysis Experiment for Freshman Chemistry Lab.

ERIC Educational Resources Information Center

Salzsieder, John C.

1995-01-01

Describes a laboratory experiment dissolving zinc from galvanized nails in which data can be gathered very quickly for statistical analysis. The data have sufficient significant figures and the experiment yields a nice distribution of random errors. Freshman students can gain an appreciation of the relationships between random error, number of…
40 CFR 160.43 - Test system care facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... testing facility shall have a number of animal rooms or other test system areas separate from those... GOOD LABORATORY PRACTICE STANDARDS Facilities § 160.43 Test system care facilities. (a) A testing facility shall have a sufficient number of animal rooms or other test system areas, as needed, to ensure...
40 CFR 160.43 - Test system care facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... testing facility shall have a number of animal rooms or other test system areas separate from those... GOOD LABORATORY PRACTICE STANDARDS Facilities § 160.43 Test system care facilities. (a) A testing facility shall have a sufficient number of animal rooms or other test system areas, as needed, to ensure...
AMMONIA ABATEMENT SYSTEM FOR WHOLE-BODY SMALL ANIMAL INHALATION EXPOSURES TO ACID MODELS

EPA Science Inventory

Conducting whole-body acid aerosol inhalation exposures of laboratory animals is complicated by ammonia arising from the excrement of the test animals which is sufficient to completely neutralize much of the acid aerosol. he neutralization of acid by ammonia con only be controlle...
DEVELOPMENT OF AN ENVIRONMENTALLY FRIENDLY AND ECONOMICAL PROCESS FOR PLUGGING ABANDONED WELLS (PHASE II)

EPA Science Inventory

The phase II of this project was successfully completed with field tests being presently underway. It was found from the laboratory study that the fly ash slurry had sufficient thickening time and could be pumped successfully through coiled and straight tubing. Pumping through...
Replicating the microbial community and water quality performance of full-scale slow sand filters in laboratory-scale filters.

PubMed

Haig, Sarah-Jane; Quince, Christopher; Davies, Robert L; Dorea, Caetano C; Collins, Gavin

2014-09-15

Previous laboratory-scale studies to characterise the functional microbial ecology of slow sand filters have suffered from methodological limitations that could compromise their relevance to full-scale systems. Therefore, to ascertain if laboratory-scale slow sand filters (L-SSFs) can replicate the microbial community and water quality production of industrially operated full-scale slow sand filters (I-SSFs), eight cylindrical L-SSFs were constructed and were used to treat water from the same source as the I-SSFs. Half of the L-SSFs sand beds were composed of sterilized sand (sterile) from the industrial filters and the other half with sand taken directly from the same industrial filter (non-sterile). All filters were operated for 10 weeks, with the microbial community and water quality parameters sampled and analysed weekly. To characterize the microbial community phyla-specific qPCR assays and 454 pyrosequencing of the 16S rRNA gene were used in conjunction with an array of statistical techniques. The results demonstrate that it is possible to mimic both the water quality production and the structure of the microbial community of full-scale filters in the laboratory - at all levels of taxonomic classification except OTU - thus allowing comparison of LSSF experiments with full-scale units. Further, it was found that the sand type composing the filter bed (non-sterile or sterile), the water quality produced, the age of the filters and the depth of sand samples were all significant factors in explaining observed differences in the structure of the microbial consortia. This study is the first to the authors' knowledge that demonstrates that scaled-down slow sand filters can accurately reproduce the water quality and microbial consortia of full-scale slow sand filters. Copyright © 2014 Elsevier Ltd. All rights reserved.
Possible risk factors for Down syndrome and sex chromosomal aneuploidy in Mysore, South India

PubMed Central

Malini, Suttur S.; Ramachandra, Nallur B.

2007-01-01

BACKGROUND: Down syndrome (DS) and sex chromosomal aneuploidy (SA) are common chromosomal anomalies causing congenital malformations and mental retardation in humans. The well-established risk factor, advanced maternal age, was not found in many of the DS and SA cases in India, while the other possible risk factors have not been well studied. In view of this, the present study has been made. MATERIALS AND METHODS: During the last 5 years, 150 clinically suspected DS and 25 SA cases were referred to our laboratory for chromosome investigation from major hospitals of Mysore city. Chromosome preparations were made from these patients after informed consent was obtained. Well-spread G-banded metaphase plates were analyzed by automated LEICA KARYO software. Two hundred and 100 randomly selected families belonging to different religions were used as controls for the DS and SA cases, respectively. Statistical analysis was carried out using logistic regression RESULTS: Out of the 150 cases of DS, 122 had free trisomy 21, two were mosaic trisomy 21, and one had translocation. Logistic regression of case-control study of DS children revealed that the odds ratio of uncle-niece marriages, or second cousin marriages, or parents lived in rural region, or exposure of the parents to chemicals, or parents education status, or habits (tobacco/ alcohol used) of father, or mother not undergone prenatal scanning, or mothers with previous abortions were significant when all the variables of that category were used one at a time. Exposure of the parents to chemicals, parents’ educational status, habits (tobacco/alcohol use) of the father, mother not undergone prenatal scanning, and history of previous abortions were significant when all the variables of that category were used one at a time. Similarly, except for consanguinity, history of previous abortions, and mother not undergone prenatal scanning, all other factors showed significant odds ratios in SA cases. CONCLUSION: Besides the known risk factors, consanguinity, region (rural/urban) of residence of parents, exposure of parents to chemicals, educational status of parents, habits of father, prenatal scanning, and reproductive performance of mother are possible risk factors for chromosomal aneuploidy. PMID:21957357
Fast laboratory-based micro-computed tomography for pore-scale research: Illustrative experiments and perspectives on the future

NASA Astrophysics Data System (ADS)

Bultreys, Tom; Boone, Marijn A.; Boone, Matthieu N.; De Schryver, Thomas; Masschaele, Bert; Van Hoorebeke, Luc; Cnudde, Veerle

2016-09-01

Over the past decade, the wide-spread implementation of laboratory-based X-ray micro-computed tomography (micro-CT) scanners has revolutionized both the experimental and numerical research on pore-scale transport in geological materials. The availability of these scanners has opened up the possibility to image a rock's pore space in 3D almost routinely to many researchers. While challenges do persist in this field, we treat the next frontier in laboratory-based micro-CT scanning: in-situ, time-resolved imaging of dynamic processes. Extremely fast (even sub-second) micro-CT imaging has become possible at synchrotron facilities over the last few years, however, the restricted accessibility of synchrotrons limits the amount of experiments which can be performed. The much smaller X-ray flux in laboratory-based systems bounds the time resolution which can be attained at these facilities. Nevertheless, progress is being made to improve the quality of measurements performed on the sub-minute time scale. We illustrate this by presenting cutting-edge pore scale experiments visualizing two-phase flow and solute transport in real-time with a lab-based environmental micro-CT set-up. To outline the current state of this young field and its relevance to pore-scale transport research, we critically examine its current bottlenecks and their possible solutions, both on the hardware and the software level. Further developments in laboratory-based, time-resolved imaging could prove greatly beneficial to our understanding of transport behavior in geological materials and to the improvement of pore-scale modeling by providing valuable validation.
FLARE: a New User Facility for Studies of Magnetic Reconnection Through Simultaneous, in-situ Measurements on MHD Scales, Ion Scales and Electron Scales

NASA Astrophysics Data System (ADS)

Ji, H.; Bhattacharjee, A.; Goodman, A.; Prager, S.; Daughton, W. S.; Cutler, R.; Fox, W.; Hoffmann, F.; Kalish, M.; Kozub, T.; Jara-Almonte, J.; Myers, C. E.; Ren, Y.; Sloboda, P.; Yamada, M.; Yoo, J.; Bale, S. D.; Carter, T.; Dorfman, S. E.; Drake, J. F.; Egedal, J.; Sarff, J.; Wallace, J.

2017-12-01

The FLARE device (Facility for Laboratory Reconnection Experiments; flare.pppl.gov) is a new laboratory experiment under construction at Princeton for the studies of magnetic reconnection in the multiple X-line regimes directly relevant to space, solar, astrophysical, and fusion plasmas, as guided by a reconnection phase diagram [Ji & Daughton, (2011)]. The whole device has been successfully assembled with rough leak check completed. The first plasmas are expected in the fall to winter. The main diagnostic is an extensive set of magnetic probe arrays to cover multiple scales from local electron scales ( ˜2 mm), to intermediate ion scales ( ˜10 cm), and global MHD scales ( ˜1 m), simultaneously providing in-situ measurements over all these relevant scales. By using these laboratory data, not only the detailed spatial profiles around each reconnecting X-line are available for direct comparisons with spacecraft data, but also the global conditions and consequences of magnetic reconnection, which are often difficult to quantify in space, can be controlled or studied systematically. The planned procedures and example topics as a user facility will be discussed in detail.
Nonoscillatory solutions for system of neutral dynamic equations on time scales.

PubMed

Chen, Zhanhe; Sun, Taixiang; Wang, Qi; Xi, Hongjian

2014-01-01

We will discuss nonoscillatory solutions to the n-dimensional functional system of neutral type dynamic equations on time scales. We will establish some sufficient conditions for nonoscillatory solutions with the property lim(t → ∞) x(i) (t) = 0, i = 1, 2,…, n.
Toward Active Control of Noise from Hot Supersonic Jets

DTIC Science & Technology

2013-11-15

several laboratory - and full- scale data sets. Two different scaling scenarios are presented for the practising scientist to choose from. The first...As will be detailed below, this simple proof-of-concept experiment yielded good quality data that reveals details about the large-scale 3D structure...the light-field. Co-PI Thurow has recently designed and assembled a plenoptic camera in his laboratory with its key attributes being its compact
Note: Measurement system for the radiative forcing of greenhouse gases in a laboratory scale.

PubMed

Kawamura, Yoshiyuki

2016-01-01

The radiative forcing of the greenhouse gases has been studied being based on computational simulations or the observation of the real atmosphere meteorologically. In order to know the greenhouse effect more deeply and to study it from various viewpoints, the study on it in a laboratory scale is important. We have developed a direct measurement system for the infrared back radiation from the carbon dioxide (CO2) gas. The system configuration is similar with that of the practical earth-atmosphere-space system. Using this system, the back radiation from the CO2 gas was directly measured in a laboratory scale, which roughly coincides with meteorologically predicted value.
The New Big Science at the NSLS

NASA Astrophysics Data System (ADS)

Crease, Robert

2016-03-01

The term ``New Big Science'' refers to a phase shift in the kind of large-scale science that was carried out throughout the U.S. National Laboratory system, when large-scale materials science accelerators rather than high-energy physics accelerators became marquee projects at most major basic research laboratories in the post-Cold War era, accompanied by important changes in the character and culture of the research ecosystem at these laboratories. This talk explores some aspects of this phase shift at BNL's National Synchrotron Light Source.
Global patterns of phytoplankton dynamics in coastal ecosystems

USGS Publications Warehouse

Paerl, H.; Yin, Kedong; Cloern, J.

2011-01-01

Scientific Committee on Ocean Research Working Group 137 Meeting; Hangzhou, China, 17-21 October 2010; Phytoplankton biomass and community structure have undergone dramatic changes in coastal ecosystems over the past several decades in response to climate variability and human disturbance. These changes have short- and long-term impacts on global carbon and nutrient cycling, food web structure and productivity, and coastal ecosystem services. There is a need to identify the underlying processes and measure the rates at which they alter coastal ecosystems on a global scale. Hence, the Scientific Committee on Ocean Research (SCOR) formed Working Group 137 (WG 137), "Global Patterns of Phytoplankton Dynamics in Coastal Ecosystems: A Comparative Analysis of Time Series Observations" (http://wg137.net/). This group evolved from a 2007 AGU-sponsored Chapman Conference entitled "Long Time-Series Observations in Coastal Ecosystems: Comparative Analyses of Phytoplankton Dynamics on Regional to Global Scales.".
The use of a resource-based relative value scale (RBRVS) to determine practice expense costs: a novel technique of practice management for the vascular surgeon.

PubMed

Mabry, C D

2001-03-01

Vascular surgeons have had to contend with rising costs while their reimbursements have undergone steady reductions. The use of newer accounting techniques can help vascular surgeons better manage their practices, plan for future expansion, and control costs. This article reviews traditional accounting methods, together with activity-based costing (ABC) principles that have been used in the past for practice expense analysis. The main focus is on a new technique-resource-based costing (RBC)-which uses the widely available Resource-Based Relative Value Scale (RBRVS) as its basis. The RBC technique promises easier implementation as well as more flexibility in determining true costs of performing various procedures, as opposed to more traditional accounting methods. It is hoped that RBC will assist vascular surgeons in coping with decreasing reimbursement. Copyright 2001 by W.B. Saunders Company
Phased Acoustic Array Measurements of a 5.75 Percent Hybrid Wing Body Aircraft

NASA Technical Reports Server (NTRS)

Burnside, Nathan J.; Horne, William C.; Elmer, Kevin R.; Cheng, Rui; Brusniak, Leon

2016-01-01

Detailed acoustic measurements of the noise from the leading-edge Krueger flap of a 5.75 percent Hybrid Wing Body (HWB) aircraft model were recently acquired with a traversing phased microphone array in the AEDC NFAC (Arnold Engineering Development Complex, National Full Scale Aerodynamics Complex) 40- by 80-Foot Wind Tunnel at NASA Ames Research Center. The spatial resolution of the array was sufficient to distinguish between individual support brackets over the full-scale frequency range of 100 to 2875 Hertz. For conditions representative of landing and take-off configuration, the noise from the brackets dominated other sources near the leading edge. Inclusion of flight-like brackets for select conditions highlights the importance of including the correct number of leading-edge high-lift device brackets with sufficient scale and fidelity. These measurements will support the development of new predictive models.
Comparison of single-dose nalbuphine versus tramadol for postoperative pain management in children: a randomized, controlled trial.

PubMed

Liaqat, Naeem; Dar, Sajid Hameed

2017-04-01

Acute postoperative pain control in children is an essential component of postoperative care, particularly in daycare procedures. Giving patients continuous narcotic analgesics can be risky; however, a single dose may be sufficient. This study used a prospective, randomized controlled design and was conducted at the Pediatric Surgery Unit, Services Hospital, Lahore. In total, 150 patients who underwent inguinal herniotomy (age range: 1-12 years) were randomly assigned to two groups: group A (nalbuphine) and group B (tramadol). Patients were given a single dose of either nalbuphine (0.2 mg/kg) or tramadol (2 mg/kg) immediately after surgery and pain was measured at 0, 1, 2, 4, and 8 h. The demographic characteristics were similar between the two groups. The mean pain score was lower in group A than in group B at 0 and 1 h (P < 0.05). However, at 4 h and 8 h, the pain scores in group A were still lower, but not significantly. In all, 9 patients (12.0%) required rescue analgesics in group A compared to 16 patients (21.3%) in group B (P = 0.051). The mean time for requirement of rescue analgesics was 6.5 ± 0.5 h in group A and 5.3 ± 1.7 h in group B (P = 0.06). A single dose of nalbuphine is sufficient, and superior to tramadol, for postoperative pain management in children who have undergone daycare procedures.

Emotional adaptation following successful in vitro fertilization.

PubMed

Hjelmstedt, Anna; Widström, Ann-Marie; Wramsby, Håkan; Collins, Aila

2004-05-01

To assess the emotional impact of infertility after successful IVF and to compare parents who have undergone IVF (IVF parents) and parents who have not undergone IVF (non-IVF parents) regarding parental stress and the marital relationship during the transition to parenthood. A study with qualitative and longitudinal quantitative assessments. University IVF clinics and antenatal clinics in Stockholm. Fifty-five IVF mothers, 53 IVF fathers, 40 non-IVF mothers, and 36 non-IVF fathers. IVF parents were interviewed. All subjects completed self-rating scales in early pregnancy and at 2 and 6 months postpartum. Interviews about perception of infertility and scalar measurement of parental stress and the marital relationship. Negative feelings related to infertility were not easily overcome among the IVF parents. Their levels of stress related to parenthood were similar to those of non-IVF parents, and both groups reported decreased satisfaction with the marital relationship during the transition to parenthood. The inability to conceive naturally continues to affect the current lives of a proportion of IVF parents. The results suggest that IVF parents may benefit from counseling with regard to the potential long-term impacts of infertility, disclosure issues, and decisions regarding future children. However, levels of parental stress and patterns of partner satisfaction are similar to those of parents with children conceived "naturally."
Validation of Placebo in a Manual Therapy Randomized Controlled Trial

PubMed Central

Chaibi, Aleksander; Šaltytė Benth, Jūratė; Bjørn Russell, Michael

2015-01-01

At present, no consensus exists among clinical and academic experts regarding an appropriate placebo for randomized controlled trials (RCTs) of spinal manipulative therapy (SMT). Therefore, we investigated whether it was possible to conduct a chiropractic manual-therapy RCT with placebo. Seventy migraineurs were randomized to a single-blinded placebo-controlled clinical trial that consisted of 12 treatment sessions over 3 months. The participants were randomized to chiropractic SMT or placebo (sham manipulation). After each session, the participants were surveyed on whether they thought they had undergone active treatment (“yes” or “no”) and how strongly they believed that active treatment was received (numeric rating scale 0–10). The outcome measures included the rate of successful blinding and the certitude of the participants’ beliefs in both treatment groups. At each treatment session, more than 80% of the participants believed that they had undergone active treatment, regardless of group allocation. The odds ratio for believing that active treatment was received was >10 for all treatment sessions in both groups (all p < 0.001). The blinding was maintained throughout the RCT. Our results strongly demonstrate that it is possible to conduct a single-blinded manual-therapy RCT with placebo and to maintain the blinding throughout 12 treatment sessions given over 3 months. PMID:26145718
Is preoperative hypocholesterolemia a risk factor for severe postoperative pain? Analysis of 1,944 patients after laparoscopic colorectal cancer surgery.

PubMed

Oh, Tak Kyu; Kang, Sung-Bum; Song, In-Ae; Hwang, Jung-Won; Do, Sang-Hwan; Kim, Jin Hee; Oh, Ah-Young

2018-01-01

This study aimed to identify the effect of preoperative serum total cholesterol on postoperative pain outcome in patients who had undergone laparoscopic colorectal cancer surgery. We retrospectively reviewed the medical records of patients diagnosed with colorectal cancer who had undergone laparoscopic colorectal surgery from January 1, 2011, to June 30, 2017, to identify the relationship of total cholesterol levels within a month prior to surgery with the numeric rating scale (NRS) scores and total opioid consumption on postoperative days (PODs) 0-2. We included 1,944 patients. No significant correlations were observed between total cholesterol and the NRS (POD 0), NRS (POD 1), and oral morphine equivalents (PODs 0-2) ( P >0.05). There was no significant difference between the low (<160 mg/dL), medium (160-199 mg/dL), and high (≥200 mg/dL) groups in NRS scores on PODs 0, 1, or 2 ( P >0.05). Furthermore, there was no significant association in multivariate linear regression analysis for postoperative opioid consumption according to preoperative serum total cholesterol level (coefficient 0.08, 95% CI -0.01 to 0.18, P =0.81). This study showed that there was no meaningful association between preoperative total cholesterol level and postoperative pain outcome after laparoscopic colorectal cancer surgery.
Intensification of anxiety and depression, and personal resources among women during the peri-operative period.

PubMed

Lewicka, Magdalena; Makara-Studzińska, Marta; Sulima, Magdalena; Wiktor, Henryk

2014-01-01

Surgical treatment of women due to gynaecological disorders is the cause of stress and may lead to psychological changes. Studies concerning human response to stress emphasize the importance of the effect of the level of the sense of coherence, anxiety, depression, dispositional optimism and skills of expressing emotions on the quality of feelings and experiences in difficult situations. The study covered 232 women who had undergone gynaecological surgery due to various causes. Permission to conduct the research was obtained from the Bioethical Commission at the Medical University in Lublin. The study was carried out with the use of the State-Trait Anxiety Inventory (STAI), the Beck Depression Inventory, Courtauld Emotional Control Scale (CECS), and Life Orientation Test - Revised (LOT-R). The study showed that investigations of the sense of coherence, level of anxiety and depression, and personal resources allow determination of the characteristics of patients who should be covered with special psycho-prophylactic care during the peri-operative period. In addition, the results of own studies obtained may be used for the development of adequate principles of psycho-prophylactic management in the course of the diagnostic-treatment process with respect to women who had undergone surgical treatment due to gynaecological disorders.
Technology to improve quality and accountability.

PubMed

Kay, Jonathan

2006-01-01

A body of evidence has been accumulated to demonstrate that current practice is not sufficiently safe for several stages of central laboratory testing. In particular, while analytical and perianalytical steps that take place within the laboratory are subjected to quality control procedures, this is not the case for several pre- and post-analytical steps. The ubiquitous application of auto-identification technology seems to represent a valuable tool for reducing error rates. A series of projects in Oxford has attempted to improve processes which support several areas of laboratory medicine, including point-of-care testing, blood transfusion, delivery and interpretation of reports, and support of decision-making by clinicians. The key tools are auto-identification, Internet communication technology, process re-engineering, and knowledge management.
Hydrodynamic Scalings: from Astrophysics to Laboratory

NASA Astrophysics Data System (ADS)

Ryutov, D. D.; Remington, B. A.

2000-05-01

A surprisingly general hydrodynamic similarity has been recently described in Refs. [1,2]. One can call it the Euler similarity because it works for the Euler equations (with MHD effects included). Although the dissipation processes are assumed to be negligible, the presence of shocks is allowed. For the polytropic medium (i.e., the medium where the energy density is proportional to the pressure), an evolution of an arbitrarily chosen 3D initial state can be scaled to another system, if a single dimensionless parameter (the Euler number) is the same for both initial states. The Euler similarity allows one to properly design laboratory experiments modeling astrophysical phenomena. We discuss several examples of such experiments related to the physics of supernovae [3]. For the problems with a single spatial scale, the condition of the smallness of dissipative processes can be adequately described in terms of the Reynolds, Peclet, and magnetic Reynolds numbers related to this scale (all three numbers must be large). However, if the system develops small-scale turbulence, dissipation may become important at these smaller scales, thereby affecting the gross behavior of the system. We analyze the corresponding constraints. We discuss also constraints imposed by the presence of interfaces between the substances with different polytropic index. Another set of similarities governs evolution of photoevaporation fronts in astrophysics. Convenient scaling laws exist in situations where the density of the ablated material is very low compared to the bulk density. We conclude that a number of hydrodynamical problems related to such objects as the Eagle Nebula can be adequately simulated in the laboratory. We discuss also possible scalings for radiative astrophysical jets (see Ref. [3] and references therein). This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract W-7405-Eng-48. 1. D.D. Ryutov, R.P. Drake, J. Kane, E. Liang, B. A. Remington, and W.M. Wood-Vasey. "Similarity criteria for the laboratory simulation of supernova hydrodynamics." Astrophysical Journal, v. 518, p. 821 (1999). 2. D.D. Ryutov, R.P. Drake, B.A. Remington. "Criteria for scaled laboratory simulations of astrophysical MHD phenomena." To appear in Astrophysical Journal - Supplement, April 2000. 3. Remington, B.A., Phys. Plasmas, 7, # 5 (2000).
LABORATORY-SCALE ANALYSIS OF AQUIFER REMEDIATION BY IN-WELL VAPOR STRIPPING 2. MODELING RESULTS. (R825689C061)

EPA Science Inventory

Abstract
The removal of volatile organic compounds (VOCs) from groundwater through in-well vapor stripping has been demonstrated by Gonen and Gvirtzman (1997, J. Contam. Hydrol., 00: 000-000) at the laboratory scale. The present study compares experimental breakthrough...
LOW OZONE-DEPLETING HALOCARBONS AS TOTAL-FLOOD AGENTS: VOLUME 2. LABORATORY-SCALE FIRE SUPPRESSION AND EXPLOSION PREVENTION TESTING

EPA Science Inventory

The report gives results from (1) flame suppression testing of potential Halon-1301 (CF3Br) replacement chemicals in a laboratory cup burner using n-heptane fuel and (2) explosion prevention (inertion) testing in a small-scale explosion sphere using propane and methane as fuels. ...
CORRELATIONS BETWEEN HOMOLOGUE CONCENTRATIONS OF PCDD/FS AND TOXIC EQUIVALENCY VALUES IN LABORATORY-, PACKAGE BOILER-, AND FIELD-SCALE INCINERATORS

EPA Science Inventory

The toxic equivalency (TEQ) values of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) are predicted with a model based on the homologue concentrations measured from a laboratory-scale reactor (124 data points), a package boiler (61 data points), and ...
Remediation and recycling of WBP-treated lumber for use as flakeboard

Treesearch

Ronald Sabo; Jerrold E. Winandy; Carol A. Clausen; Altaf Basta

2008-01-01

Laboratory-scale experiments were conducted in which preservative metals (As, Cr, & Cu) were thermochemically extracted from CCA-treated spruce (Picea engelmannii) using oxalic acid and sodium hydroxide. The effects of extraction time, temperature, and pH were examined and laboratory scale optimization was achieved. Two series of experiments were carried out. In...
Improved Strength and Damage Modeling of Geologic Materials

NASA Astrophysics Data System (ADS)

Stewart, Sarah; Senft, Laurel

2007-06-01

Collisions and impact cratering events are important processes in the evolution of planetary bodies. The time and length scales of planetary collisions, however, are inaccessible in the laboratory and require the use of shock physics codes. We present the results from a new rheological model for geological materials implemented in the CTH code [1]. The `ROCK' model includes pressure, temperature, and damage effects on strength, as well as acoustic fluidization during impact crater collapse. We demonstrate that the model accurately reproduces final crater shapes, tensile cracking, and damaged zones from laboratory to planetary scales. The strength model requires basic material properties; hence, the input parameters may be benchmarked to laboratory results and extended to planetary collision events. We show the effects of varying material strength parameters, which are dependent on both scale and strain rate, and discuss choosing appropriate parameters for laboratory and planetary situations. The results are a significant improvement in models of continuum rock deformation during large scale impact events. [1] Senft, L. E., Stewart, S. T. Modeling Impact Cratering in Layered Surfaces, J. Geophys. Res., submitted.
Nonoscillatory Solutions for System of Neutral Dynamic Equations on Time Scales

PubMed Central

Chen, Zhanhe; Wang, Qi; Xi, Hongjian

2014-01-01

We will discuss nonoscillatory solutions to the n-dimensional functional system of neutral type dynamic equations on time scales. We will establish some sufficient conditions for nonoscillatory solutions with the property limt→∞ ⁡x i(t) = 0, i = 1, 2,…, n. PMID:24757436
PILOT STUDY: Report on the CCPR Pilot Comparison: Spectral Responsivity 10 nm to 20 nm

NASA Astrophysics Data System (ADS)

Scholze, Frank; Vest, Robert; Saito, Terubumi

2010-01-01

The CCPR Pilot Comparison on spectral responsivity in the 10 nm to 20 nm spectral range was carried out within the framework of the CIPM Mutual Recognition Arrangement by three laboratories: PTB (Germany), NIST (USA), and NMIJ/AIST (Japan) with PTB acting as the central and reporting laboratory. All participating laboratories used monochromatized synchrotron radiation. PTB and NIST used a cryogenic radiometer as the primary standard detector and NMIJ, an ionization chamber with extrapolation by a wavelength-independent detector. The aim of the pilot comparison was to check the accuracy of the radiometric scale of spectral responsivity in the short wavelength EUV spectral range which has recently gained in technological importance. The wavelengths of measurement were from 11.5 nm to 20 nm in 0.5 nm steps and additionally 12.2 nm. The comparison was carried out through the calibration of a group of transfer standard detectors. Two sets of three diodes of types AXUV and SXUV from International Radiation Detectors, Inc. were used for the comparison. The comparison had the form of a star comparison: Pilot-lab A-pilot-lab B-pilot, PTB acting as the pilot laboratory. All results were communicated directly to the pilot laboratory. The report describes in detail the measurements made at PTB and summarizes the reports submitted by the participants. Measurements carried out by the pilot laboratory before and after the circulation of the detectors proved that the stability of the detectors was sufficient for the comparison. For the type AXUV detectors, however, changes in their responsivity contributed to the uncertainty of the comparison. Measurement results from participants and their associated uncertainties were analyzed in this report according to the Guidelines for CCPR Comparison Report Preparation. The uncertainty contributions were separated, as to whether they are wavelength dependent or not. All bilateral DoE are well within the respective k = 2 expanded uncertainty ranges for all wavelengths. The separated non-wavelength-dependent and wavelength-dependent uncertainty contributions are consistent with the respective wavelength-averaged DoE and wavelength-dependent variations of all bilateral DoE. Main text. To reach the main text of this paper, click on Final Report. The final report has been peer-reviewed and approved for publication by the CCPR WG-KC
Enhanced Verification Test Suite for Physics Simulation Codes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamm, J R; Brock, J S; Brandon, S T

2008-10-10

This document discusses problems with which to augment, in quantity and in quality, the existing tri-laboratory suite of verification problems used by Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and Sandia National Laboratories (SNL). The purpose of verification analysis is demonstrate whether the numerical results of the discretization algorithms in physics and engineering simulation codes provide correct solutions of the corresponding continuum equations. The key points of this document are: (1) Verification deals with mathematical correctness of the numerical algorithms in a code, while validation deals with physical correctness of a simulation in a regime of interest.more » This document is about verification. (2) The current seven-problem Tri-Laboratory Verification Test Suite, which has been used for approximately five years at the DOE WP laboratories, is limited. (3) Both the methodology for and technology used in verification analysis have evolved and been improved since the original test suite was proposed. (4) The proposed test problems are in three basic areas: (a) Hydrodynamics; (b) Transport processes; and (c) Dynamic strength-of-materials. (5) For several of the proposed problems we provide a 'strong sense verification benchmark', consisting of (i) a clear mathematical statement of the problem with sufficient information to run a computer simulation, (ii) an explanation of how the code result and benchmark solution are to be evaluated, and (iii) a description of the acceptance criterion for simulation code results. (6) It is proposed that the set of verification test problems with which any particular code be evaluated include some of the problems described in this document. Analysis of the proposed verification test problems constitutes part of a necessary--but not sufficient--step that builds confidence in physics and engineering simulation codes. More complicated test cases, including physics models of greater sophistication or other physics regimes (e.g., energetic material response, magneto-hydrodynamics), would represent a scientifically desirable complement to the fundamental test cases discussed in this report. The authors believe that this document can be used to enhance the verification analyses undertaken at the DOE WP Laboratories and, thus, to improve the quality, credibility, and usefulness of the simulation codes that are analyzed with these problems.« less
Convective patterns under the Indo-Atlantic << box >> [rapid communication

NASA Astrophysics Data System (ADS)

Davaille, Anne; Stutzmann, Eléonore; Silveira, Graça; Besse, Jean; Courtillot, Vincent

2005-11-01

Using fluid mechanics, we reinterpret the mantle images obtained from global and regional tomography together with geochemical, geological and paleomagnetic observations, and attempt to unravel the pattern of convection in the Indo-Atlantic "box" and its temporal evolution over the last 260 Myr. The « box » presently contains a) a broad slow seismic anomaly at the CMB which has a shape similar to Pangea 250 Myr ago, and which divides into several branches higher in the lower mantle, b) a "superswell" centered on the western edge of South Africa, c) at least 6 "primary hotspots" with long tracks related to traps, and d) numerous smaller hotspots. In the last 260 Myr, this mantle box has undergone 10 trap events, 7 of them related to continental breakup. Several of these past events are spatially correlated with present-day seismic anomalies and/or upwellings. Laboratory experiments show that superswells, long-lived hotspot tracks and traps may represent three evolutionary stages of the same phenomenon, i.e. episodic destabilization of a hot, chemically heterogeneous thermal boundary layer, close to the bottom of the mantle. When scaled to the Earth's mantle, its recurrence time is on the order of 100-200 Myr. At any given time, the Indo-Atlantic box should contain 3 to 9 of these instabilities at different stages of their development, in agreement with observations. The return flow of the downwelling slabs, although confined to two main « boxes » (Indo-Atlantic and Pacific) by subduction zone geometry, may therefore not be passive, but rather take the form of active thermochemical instabilities.
Genomic Consequences of Population Decline in the Endangered Florida Scrub-Jay.

PubMed

Chen, Nancy; Cosgrove, Elissa J; Bowman, Reed; Fitzpatrick, John W; Clark, Andrew G

2016-11-07

Understanding the population genetic consequences of declining population size is important for conserving the many species worldwide facing severe decline [1]. Thorough empirical studies on the impacts of population reduction at a genome-wide scale in the wild are scarce because they demand huge field and laboratory investments [1, 2]. Previous studies have demonstrated the importance of gene flow in introducing genetic variation to small populations [3], but few have documented both genetic and fitness consequences of decreased immigration through time in a natural population [4-6]. Here we assess temporal variation in gene flow, inbreeding, and fitness using longitudinal genomic, demographic, and phenotypic data from a long-studied population of federally Threatened Florida scrub-jays (Aphelocoma coerulescens). We exhaustively sampled and genotyped the study population over two decades, providing one of the most detailed longitudinal investigations of genetics in a wild animal population to date. Immigrants were less heterozygous than residents but still introduced genetic variation into our study population. Owing to regional population declines, immigration into the study population declined from 1995-2013, resulting in increased levels of inbreeding and reduced fitness via inbreeding depression, even as the population remained demographically stable. Our results show that, contrary to conventional wisdom, small peripheral populations that already have undergone a genetic bottleneck may play a vital role in preserving genetic diversity of larger and seemingly stable populations. These findings underscore the importance of investing in the persistence of small populations and maintaining population connectivity in conservation of fragmented species. Copyright © 2016 Elsevier Ltd. All rights reserved.
Galileo and optical illusion

NASA Astrophysics Data System (ADS)

Parker, Gary D.

1986-03-01

Galileo's earliest telescopic measurements are of sufficient quality that their detailed analysis yields scientifically interesting and pedagogically useful results. An optical illusion strongly influences Galileo's observations of Jupiter's moons, as published in the Starry Messenger. A simple procedure identifies individual satellites with sufficient reliability to demonstrate that Galileo regularly underestimated satellite brightness and overestimated elongation when a satellite was very close to Jupiter. The probability of underestimation is a monotonically decreasing function of separation angle, both for Galileo and for viewers of a laboratory simulation of the Jupiter ``starfield'' viewed by Galileo. Analysis of Galileo's records and a simple simulation experiment appropriate to undergraduate courses clarify the scientific problems facing Galileo in interpreting his observations.
Evolution of the central Atlantic hot spots cluster in the last 100 Myr: interaction between plate tectonics, a lower mantle thermochemical instability and upper mantle secondary plumes

NASA Astrophysics Data System (ADS)

Sibrant, A.; Davaille, A.; Marques, F. O.; Hildenbrand, A.

2014-12-01

Born 200 Ma ago, the central Atlantic presents nowadays a large low seismic velocity anomaly in the lower mantle, a cluster of "hot" spots (Azores, Cape Verde, Madeira, Canary, Great Meteor), a mid-ocean ridge, and a triple junction located in the Azores. We carried out laboratory experiments to examine the possible links between mantle instabilities, plate boundary migration, and the development of the volcanism on various spatial and temporal scales. Coupled with the current knowledge of these volcanic areas (tomography, tectonics and K/Ar dating), our fluid mechanics experiments suggest that: (1) The Azores, as Canary, Cape Verde, Madeira Islands and Great Meteor seamounts might be the surface expression of a cluster of mantle instabilities rising from the top of a large thermochemical dome located in the lower mantle. However, such secondary plumes present a strong time-dependence 5-40 Myr time scale. (2) These secondary instabilities could be sufficiently weak to adapt their motions to the pre-existing force balance, and morphology and mechanical properties of the lithosphere. Based on current knowledge and modelling, we present a scenario of the Central Atlantic area evolution in the last 100 Ma combining a triple junction and decompression melting-generated buoyant material (i.e. such in volatiles and/or temperature) under a cooling and thickening lithosphere.
Powering up with indirect reciprocity in a large-scale field experiment

PubMed Central

Yoeli, Erez; Hoffman, Moshe; Rand, David G.; Nowak, Martin A.

2013-01-01

A defining aspect of human cooperation is the use of sophisticated indirect reciprocity. We observe others, talk about others, and act accordingly. We help those who help others, and we cooperate expecting that others will cooperate in return. Indirect reciprocity is based on reputation, which spreads by communication. A crucial aspect of indirect reciprocity is observability: reputation effects can support cooperation as long as peoples’ actions can be observed by others. In evolutionary models of indirect reciprocity, natural selection favors cooperation when observability is sufficiently high. Complimenting this theoretical work are experiments where observability promotes cooperation among small groups playing games in the laboratory. Until now, however, there has been little evidence of observability’s power to promote large-scale cooperation in real world settings. Here we provide such evidence using a field study involving 2413 subjects. We collaborated with a utility company to study participation in a program designed to prevent blackouts. We show that observability triples participation in this public goods game. The effect is over four times larger than offering a $25 monetary incentive, the company’s previous policy. Furthermore, as predicted by indirect reciprocity, we provide evidence that reputational concerns are driving our observability effect. In sum, we show how indirect reciprocity can be harnessed to increase cooperation in a relevant, real-world public goods game. PMID:23754399
Alkaline fermentation of waste activated sludge stimulated by saponin: volatile fatty acid production, mechanisms and pilot-scale application.

PubMed

Huang, Xiangfeng; Mu, Tianshuai; Shen, Changming; Lu, Lijun; Liu, Jia

2016-12-01

Volatile fatty acid (VFA) production stimulated by saponin (SP), an environmentally friendly bio-surfactant, was investigated during sludge alkaline fermentation in laboratory studies and pilot applications. The combined use of SP and pH 9 condition significantly enhanced VFA production to approximately 425 mg COD/g VSS, which was 4.7-fold of raw sludge and 1.5-fold of sole pH 10 adjustment (the optimum pH for alkaline fermentation). Further results indicated that SP & pH 9 condition provided sufficient substrates for acidification and decreased the consumption of VFAs through methanogenesis. Moreover, SP accompanied by moderate alkaline condition (i.e. pH 9) showed weaker inhibitory effects on key enzyme activities and metabolic potential of acidification microorganisms than sole pH 10 adjustment. On this basis, a pilot-scale system involving anaerobic fermentation and anaerobic-anoxic-aerobic step-feed bioreaction tanks was established to study the potential of VFAs as supplementary carbon sources for wastewater treatment. The influent of the pilot system was sanitary wastewater characterized by low C/N ratios from a scenic rural area. After flocculation and nutrient precipitation, the fermentation supernatant was mixed with the influent at a volume ratio of 1:30. With this approach, nitrogen and phosphorus concentrations in effluent fulfilled the first-A wastewater discharge standard in China.

Current-Sheet Formation and Reconnection at a Magnetic X Line in Particle-in-Cell Simulations

NASA Technical Reports Server (NTRS)

Black, C.; Antiochos, S. K.; Hesse, M.; Karpen, J. T.; Kuznetsova, M. M.; Zenitani, S.

2011-01-01

The integration of kinetic effects into macroscopic numerical models is currently of great interest to the heliophysics community, particularly in the context of magnetic reconnection. Reconnection governs the large-scale energy release and topological rearrangement of magnetic fields in a wide variety of laboratory, heliophysical, and astrophysical systems. We are examining the formation and reconnection of current sheets in a simple, two-dimensional X-line configuration using high-resolution particle-in-cell (PIC) simulations. The initial minimum-energy, potential magnetic field is perturbed by excess thermal pressure introduced into the particle distribution function far from the X line. Subsequently, the relaxation of this added stress leads self-consistently to the development of a current sheet that reconnects for imposed stress of sufficient strength. We compare the time-dependent evolution and final state of our PIC simulations with macroscopic magnetohydrodynamic simulations assuming both uniform and localized electrical resistivities (C. R. DeVore et al., this meeting), as well as with force-free magnetic-field equilibria in which the amount of reconnection across the X line can be constrained to be zero (ideal evolution) or optimal (minimum final magnetic energy). We will discuss implications of our results for understanding magnetic-reconnection onset and cessation at kinetic scales in dynamically formed current sheets, such as those occurring in the solar corona and terrestrial magnetotail.
Correlating field and laboratory rates of particle abrasion, Rio Medio, Sangre de Cristo Mountains, New Mexico

NASA Astrophysics Data System (ADS)

Polito, P. J.; Sklar, L. S.

2006-12-01

River bed sediments commonly fine downstream due to a combination of particle abrasion, selective transport of finer grains, and fining of the local sediment supply from hillslopes and tributaries. Particle abrasion rates can be directly measured in the laboratory using tumbling barrels and annular flumes, however, scaling experimental particle abrasion rates to the field has proven difficult due to the confounding effects of selective transport and local supply variations. Here we attempt to correlate laboratory and field rates of particle abrasion in a field setting where these confounding effects can be controlled. The Rio Medio, which flows westward from the crest of the Sangre de Cristo Mountains in north central New Mexico, is one of several streams studied by John P. Miller in the early 1960's. Several kilometers downstream of its headwaters, the river crosses the Picuris-Pecos fault. Upstream of the fault the river receives quartzite, sandstone and shale clasts from the Ortega Formation, while downstream sediments are supplied by the Embudo Granite. Because the upstream lithologies are not resupplied downstream of the fault, any observed fining of these clasts should be due only to abrasion and selective transport. We hypothesize that we can account for the effects of selective transport by comparing relative fining rates for the different upstream lithologies from both the field and a laboratory tumbler. By correlating laboratory abrasion rates with rock strength, we can predict the relative fining rates due solely to abrasion expected in the field; differences between the predicted and observed fining rates could then be attributed to selective transport. We used point counts to measure bed surface sediment grain size distributions at 15 locations along a 25 kilometer reach of the Rio Medio, beginning just downstream of the fault and ending upstream of a developed area with disturbed channel conditions. We recorded intermediate particle diameter as well as lithologic composition for 100 clasts at each location. To better characterize the size distribution of poorly represented lithologies we also measured every grain we could find of these minority lithologies within a one square meter area on adjacent bar top surfaces. At each sampling site we also measured channel gradient, and bank-full width and depth. We collected gravel samples for laboratory tumbling experiments and larger bedrock blocks from which we extracted cores for the Brazilian tensile splitting strength test. Preliminary results show very rapid fining of the weak sedimentary rocks downstream of the fault, much less rapid fining of the quartzite and a net downstream coarsening of the granitic sediments, which dominate the bed in the downstream end of the study reach. This enigmatic downstream coarsening may be a legacy of Pliestocene glaciation, which is evident in the landscape upstream of the fault. Outburst floods or debris flows from upstream moraines may have delivered large quantities of coarse sediments to downstream reaches, which are now relatively immobile. Despite these complications, the Rio Medio site may yet provide sufficient information to test our proposed method for scaling laboratory particle abrasion rates to the field.
On the origin of the HLX-1 outbursts

NASA Astrophysics Data System (ADS)

Sun, Mouyuan; Gu, Wei-Min; Yan, Zhen; Wu, Qingwen; Liu, Tong

2016-11-01

HLX-1, currently the best intermediate-mass black hole candidate, has undergone seven violent outbursts, each with a peak X-ray luminosity of Lpeak,X ˜ 1042 erg s-1. Interestingly, the properties of the HLX-1 outbursts evolve with time. In this work, we aim to constrain the physical parameters of the central engine of the HLX-1 outbursts in the framework of the black hole accretion. We find that the physical properties of the HLX-1 outbursts are consistent with being driven by the radiation pressure instability. This scenario can explain the evolution of the recurrent time-scales of the HLX-1 outbursts as a function of the durations.
Laboratory Modelling of Volcano Plumbing Systems: a review

NASA Astrophysics Data System (ADS)

Galland, Olivier; Holohan, Eoghan P.; van Wyk de Vries, Benjamin; Burchardt, Steffi

2015-04-01

Earth scientists have, since the XIX century, tried to replicate or model geological processes in controlled laboratory experiments. In particular, laboratory modelling has been used study the development of volcanic plumbing systems, which sets the stage for volcanic eruptions. Volcanic plumbing systems involve complex processes that act at length scales of microns to thousands of kilometres and at time scales from milliseconds to billions of years, and laboratory models appear very suitable to address them. This contribution reviews laboratory models dedicated to study the dynamics of volcano plumbing systems (Galland et al., Accepted). The foundation of laboratory models is the choice of relevant model materials, both for rock and magma. We outline a broad range of suitable model materials used in the literature. These materials exhibit very diverse rheological behaviours, so their careful choice is a crucial first step for the proper experiment design. The second step is model scaling, which successively calls upon: (1) the principle of dimensional analysis, and (2) the principle of similarity. The dimensional analysis aims to identify the dimensionless physical parameters that govern the underlying processes. The principle of similarity states that "a laboratory model is equivalent to his geological analogue if the dimensionless parameters identified in the dimensional analysis are identical, even if the values of the governing dimensional parameters differ greatly" (Barenblatt, 2003). The application of these two steps ensures a solid understanding and geological relevance of the laboratory models. In addition, this procedure shows that laboratory models are not designed to exactly mimic a given geological system, but to understand underlying generic processes, either individually or in combination, and to identify or demonstrate physical laws that govern these processes. From this perspective, we review the numerous applications of laboratory models to understand the distinct key features of volcanic plumbing systems: dykes, cone sheets, sills, laccoliths, caldera-related structures, ground deformation, magma/fault interactions, and explosive vents. Barenblatt, G.I., 2003. Scaling. Cambridge University Press, Cambridge. Galland, O., Holohan, E.P., van Wyk de Vries, B., Burchardt, S., Accepted. Laboratory modelling of volcanic plumbing systems: A review, in: Breitkreuz, C., Rocchi, S. (Eds.), Laccoliths, sills and dykes: Physical geology of shallow level magmatic systems. Springer.
The Tanzania experience: clinical laboratory testing harmonization and equipment standardization at different levels of a tiered health laboratory system.

PubMed

Massambu, Charles; Mwangi, Christina

2009-06-01

The rapid scale-up of the care and treatment programs in Tanzania during the preceding 4 years has greatly increased the demand for quality laboratory services for diagnosis of HIV and monitoring patients during antiretroviral therapy. Laboratory services were not in a position to cope with this demand owing to poor infrastructure, lack of human resources, erratic and/or lack of reagent supply and commodities, and slow manual technologies. With the limited human resources in the laboratory and the need for scaling up the care and treatment program, it became necessary to install automated equipment and train personnel for the increased volume of testing and new tests across all laboratory levels. With the numerous partners procuring equipment, the possibility of a multitude of equipment platforms with attendant challenges for procurement of reagents, maintenance of equipment, and quality assurance arose. Tanzania, therefore, had to harmonize laboratory tests and standardize laboratory equipment at different levels of the laboratory network. The process of harmonization of tests and standardization of equipment included assessment of laboratories, review of guidelines, development of a national laboratory operational plan, and stakeholder advocacy. This document outlines this process.
Laboratory Applications of the Vortex Tube.

ERIC Educational Resources Information Center

Bruno, Thomas J.

1987-01-01

Discussed are a brief explanation of the function of the vortex tube and some applications for the chemistry laboratory. It is a useful and inexpensive solution to many small-scale laboratory heating and cooling applications. (RH)
Quality Indicators of Cervical Cytopathology Tests in the Public Service in Minas Gerais, Brazil.

PubMed

Tobias, Alessandra Hermógenes Gomes; Amaral, Rita Goreti; Diniz, Elói Martins; Carneiro, Cláudia Martins

2016-02-01

The objective of this study is to assess the performance of cytopathology laboratories providing services to the Brazilian Unified Health System (Sistema Único de Saúde - SUS) in the State of Minas Gerais, Brazil. This descriptive study uses data obtained from the Cervical Cancer Information System from January to December 2012. Three quality indicators were analyzed to assess the quality of cervical cytopathology tests: positivity index, percentage of atypical squamous cells (ASCs) in abnormal tests, and percentage of tests compatible with high-grade squamous intraepithelial lesions (HSILs). Laboratories were classified according to their production scale in tests per year ≤ 5,000; from 5,001 to 10,000; from 10,001 to 15,000; and ≥ 15,001. Based on the collection of variables and the classification of laboratories according to production scale, we created and analyzed a database using Microsoft Office Excel 97-2003. In the Brazilian state of Minas Gerais, 146 laboratories provided services to the SUS in 2012 by performing a total of 1,277,018 cervical cytopathology tests. Half of these laboratories had production scales ≤ 5,000 tests/year and accounted for 13.1% of all tests performed in the entire state; in turn, 13.7% of these laboratories presented production scales of > 15,001 tests/year and accounted for 49.2% of the total of tests performed in the entire state. The positivity indexes of most laboratories providing services to the SUS in 2012, regardless of production scale, were below or well below recommended limits. Of the 20 laboratories that performed more than 15,001 tests per year, only three presented percentages of tests compatible with HSILs above the lower limit recommended by the Brazilian Ministry of Health. The majority of laboratories providing services to the SUS in Minas Gerais presented quality indicators outside the range recommended by the Brazilian Ministry of Health. Thieme Publicações Ltda Rio de Janeiro, Brazil.
Task 2 Report - A GIS-Based Technical Potential Assessment of Domestic Energy Resources for Electricity Generation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Nathan; Grue, Nicholas W; Rosenlieb, Evan

The purpose of this report is to support the Lao Ministry of Energy and Mines in assessing the technical potential of domestic energy resources for utility scale electricity generation in the Lao PDR. Specifically, this work provides assessments of technical potential, and associated maps of developable areas, for energy technologies of interest. This report details the methodology, assumptions, and datasets employed in this analysis to provide a transparent, replicable process for future analyses. The methodology and results presented are intended to be a fundamental input to subsequent decision making and energy planning-related analyses. This work concentrates on domestic energy resourcesmore » for utility-scale electricity generation and considers solar photovoltaic, wind, biomass, and coal resources. This work does not consider potentially imported energy resources (e.g., natural gas) or domestic energy resources that are not present in sufficient quantity for utility-scale generation (e.g., geothermal resources). A technical potential assessment of hydropower resources is currently not feasible due to the absence of required data including site-level assessments of multiple characteristics (e.g., geology environment and access) as well as spatial data on estimated non-exploited hydropower resources. This report is the second output of the Energy Alternatives Study for the Lao PDR, a collaboration led by the Lao Ministry of Energy and Mines and the United States Agency for International Development under the auspices of the Smart Infrastructure for the Mekong program. The Energy Alternatives Study is composed of five successive tasks that collectively support the project's goals. This work is focused on Task 2 - Assess technical potential of domestic energy resources for electricity generation. The work was carried out by a team from the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) in collaboration with the Lao Ministry of Energy and Mines and other Lao power sector stakeholders. and datasets employed in this analysis to provide a transparent, replicable process for future analyses. The methodology and results presented are intended to be a fundamental input to subsequent decision making and energy planning-related analyses. This work concentrates on domestic energy resources for utility-scale electricity generation and considers solar photovoltaic, wind, biomass, and coal resources. This work does not consider potentially imported energy resources (e.g., natural gas) or domestic energy resources that are not present in sufficient quantity for utility-scale generation (e.g., geothermal resources). A technical potential assessment of hydropower resources is currently not feasible due to the absence of required data including site-level assessments of multiple characteristics (e.g., geology environment and access) as well as spatial data on estimated non-exploited hydropower resources.« less
[Membrane-filtration immunoassay: reagents, methods and the diagnostic and technical means for detection].

PubMed

Khramov, E N; Osin, N S; Pomelova, V G; Vikha, I V; Bychenkova, T A; Smirnova, V G; Grakina, G I; Kas'ianova, T A

1999-01-01

The comprehensive development of dot-EIA made at the State Research Institute of Biological Instrument-Making Industry has provided devices KIMF-02 and KIMF-03), a base of chemical reagents, immunoassays, test systems for detection of a wide range of causative agents of viral and bacterial infections, that of serodiagnosis of their related diseases. The KIMF-02 kit has undergone engineering and medical tests and recommended for the Ministry of Health of the Russian Federation to produce them in stock. The kit includes all required for analysis even in an ill-equipped laboratory, a set of attached agents ensures a valid visual recording of results. The developed procedures and test systems allow the immunoassay to be as sensitive as TIFA; however, they are laborious and much simpler in design. The simple and rapid procedures of dot-EIA are recommended for incorporation into the a package of laboratory methods for verification of the accumulation of virus-specific antigens in various biological substrata, environmental samples, for control of the activity of antigens and antibodies used in serological tests, for detection of specific antigens in the clinical samples, and for serodiagnosis of infections.
Creation and Validation of the Cognitive and Behavioral Response to Stress Scale in a Depression Trial

PubMed Central

Miner, Adam S.; Schueller, Stephen M.; Lattie, Emily G.; Mohr, David C.

2015-01-01

The Cognitive and Behavioral Response to Stress Scale (CB-RSS) is a self-report measure of the use and helpfulness of several cognitive and behavioral skills. Unlike other measures that focus on language specific to terms used in therapy, the CB-RSS was intended to tap the strategies in ways that might be understandable to those who had not undergone therapy. The measure was included in a clinical trial of cognitive-behavioral therapy for depression and completed by 325 participants at baseline and end of treatment (18 weeks). Psychometric properties of the scale were assessed through iterative exploratory and confirmatory factor analyses. These analyses identified two subscales, cognitive and behavioral skills, each with high reliability. Validity was addressed by investigating relationships with depression symptoms, positive affect, perceived stress, and coping self-efficacy. End of treatment scores predicted changes in all outcomes, with the largest relationships between baseline CB-RSS scales and coping self-efficacy. These findings suggest that the CB-RSS is a useful tool to measure cognitive and behavioral skills both at baseline (prior to treatment) as well as during the course of treatment. Keywords: Development, Validation, Telehealth PMID:26553147
Factor analysis of the catatonia rating scale and catatonic symptom distribution across four diagnostic groups.

PubMed

Krüger, Stephanie; Bagby, R Michael; Höffler, Jürgen; Bräunig, Peter

2003-01-01

Catatonia is a frequent psychomotor syndrome, which has received increasing recognition over the last decade. The assessment of the catatonic syndrome requires systematic rating scales that cover the complex spectrum of catatonic motor signs and behaviors. The Catatonia Rating Scale (CRS) is such an instrument, which has been validated and which has undergone extensive reliability testing. In the present study, to further validate the CRS, the items composing this scale were submitted to principal components factor extraction followed by a varimax rotation. An analysis of variance (ANOVA) was performed to assess group differences on the extracted factors in patients with schizophrenia, pure mania, mixed mania, and major depression (N=165). Four factors were extracted, which accounted for 71.5% of the variance. The factors corresponded to the clinical syndromes of (1) catatonic excitement, (2) abnormal involuntary movements/mannerisms, (3) disturbance of volition/catalepsy, and (4) catatonic inhibition. The ANOVA revealed that each of the groups showed a distinctive catatonic symptom pattern and that the overlap between diagnostic groups was minimal. We conclude that this four-factor symptom structure of catatonia challenges the current conceptualization, which proposes only two symptom subtypes.
Creation and validation of the Cognitive and Behavioral Response to Stress Scale in a depression trial.

PubMed

Miner, Adam S; Schueller, Stephen M; Lattie, Emily G; Mohr, David C

2015-12-30

The Cognitive and Behavioral Response to Stress Scale (CB-RSS) is a self-report measure of the use and helpfulness of several cognitive and behavioral skills. Unlike other measures that focus on language specific to terms used in therapy, the CB-RSS was intended to tap the strategies in ways that might be understandable to those who had not undergone therapy. The measure was included in a clinical trial of cognitive-behavioral therapy for depression and completed by 325 participants at baseline and end of treatment (18 weeks). Psychometric properties of the scale were assessed through iterative exploratory and confirmatory factor analyses. These analyses identified two subscales, cognitive and behavioral skills, each with high reliability. Validity was addressed by investigating relationships with depression symptoms, positive affect, perceived stress, and coping self-efficacy. End of treatment scores predicted changes in all outcomes, with the largest relationships between baseline CB-RSS scales and coping self-efficacy. These findings suggest that the CB-RSS is a useful tool to measure cognitive and behavioral skills both at baseline (prior to treatment) as well as during the course of treatment. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Biology meets physics: Reductionism and multi-scale modeling of morphogenesis.

PubMed

Green, Sara; Batterman, Robert

2017-02-01

A common reductionist assumption is that macro-scale behaviors can be described "bottom-up" if only sufficient details about lower-scale processes are available. The view that an "ideal" or "fundamental" physics would be sufficient to explain all macro-scale phenomena has been met with criticism from philosophers of biology. Specifically, scholars have pointed to the impossibility of deducing biological explanations from physical ones, and to the irreducible nature of distinctively biological processes such as gene regulation and evolution. This paper takes a step back in asking whether bottom-up modeling is feasible even when modeling simple physical systems across scales. By comparing examples of multi-scale modeling in physics and biology, we argue that the "tyranny of scales" problem presents a challenge to reductive explanations in both physics and biology. The problem refers to the scale-dependency of physical and biological behaviors that forces researchers to combine different models relying on different scale-specific mathematical strategies and boundary conditions. Analyzing the ways in which different models are combined in multi-scale modeling also has implications for the relation between physics and biology. Contrary to the assumption that physical science approaches provide reductive explanations in biology, we exemplify how inputs from physics often reveal the importance of macro-scale models and explanations. We illustrate this through an examination of the role of biomechanical modeling in developmental biology. In such contexts, the relation between models at different scales and from different disciplines is neither reductive nor completely autonomous, but interdependent. Copyright © 2016 Elsevier Ltd. All rights reserved.
Electroporation System for Sterilizing Water

NASA Technical Reports Server (NTRS)

Schlager, Kenneth J.

2005-01-01

A prototype of an electroporation system for sterilizing wastewater or drinking water has been developed. In electroporation, applied electric fields cause transient and/or permanent changes in the porosities of living cells. Electroporation at lower field strengths can be exploited to increase the efficiency of chemical disinfection (as in chlorination). Electroporation at higher field strengths is capable of inactivating and even killing bacteria and other pathogens, without use of chemicals. Hence, electroporation is at least a partial alternative to chlorination. The transient changes that occur in micro-organisms at lower electric-field strengths include significantly increased uptake of ions and molecules. Such increased uptake makes it possible to achieve disinfection at lower doses of chemicals (e.g., chlorine or ozone) than would otherwise be needed. Lower doses translate to lower costs and reduced concentrations of such carcinogenic chemical byproducts as trichloromethane. Higher electric fields cause cell membranes to lose semipermeability and thereby become unable to function as selective osmotic barriers between the cells and the environment. This loss of function is the cause of the cell death at higher electric-field intensities. Experimental evidence does not indicate cell lysis but, rather, combined leaking of cell proteins out of the cells as well as invasion of foreign chemical compounds into the cells. The concept of electroporation is not new: it has been applied in molecular biology and genetic engineering for decades. However, the laboratory-scale electroporators used heretofore have been built around small (400-microliter) cuvettes, partly because the smallness facilitates the generation of electric fields of sufficient magnitude to cause electroporation. Moreover, most laboratory- scale electroporators have been designed for testing static water. In contrast, the treatment cell in the present system is much larger and features a flow-through geometry, such that electric fields strong enough to effect 99.9- percent disinfection can be applied to water flowing in a pipe.
Renewable Water: Direct Contact Membrane Distillation Coupled With Solar Ponds

NASA Astrophysics Data System (ADS)

Suarez, F. I.; Tyler, S. W.; Childress, A. E.

2010-12-01

The exponential population growth and the accelerated increase in the standard of living have increased significantly the global consumption of two precious resources: water and energy. These resources are intrinsically linked and are required to allow a high quality of human life. With sufficient energy, water may be harvested from aquifers, treated for potable reuse, or desalinated from brackish and seawater supplies. Even though the costs of desalination have declined significantly, traditional desalination systems still require large quantities of energy, typically from fossil fuels that will not allow these systems to produce water in a sustainable way. Recent advances in direct contact membrane distillation can take advantage of low-quality or renewable heat to desalinate brackish water, seawater or wastewater. Direct contact membrane distillation operates at low pressures and can use small temperature differences between the feed and permeate water to achieve a significant freshwater production. Therefore, a much broader selection of energy sources can be considered to drive thermal desalination. A promising method for providing renewable source of heat for direct contact membrane distillation is a solar pond, which is an artificially stratified water body that captures solar radiation and stores it as thermal energy at the bottom of the pond. In this work, a direct contact membrane distillation/solar pond coupled system is modeled and tested using a laboratory-scale system. Freshwater production rates on the order of 2 L day-1 per m2 of solar pond (1 L hr-1 per m2 of membrane area) can easily be achieved with minimal operating costs and under low pressures. While these rates are modest, they are six times larger than those produced by other solar pond-powered desalination systems - and they are likely to be increased if heat losses in the laboratory-scale system are reduced. Even more, this system operates at much lower costs than traditional desalination systems, thus, it can be used to meet the future needs of energy and water use in a sustainable way.
H2@Scale Workshop Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pivovar, Bryan

2017-03-31

Final report from the H2@Scale Workshop held November 16-17, 2016, at the National Renewable Energy Laboratory in Golden, Colorado. The U.S. Department of Energy's National Renewable Energy Laboratory hosted a technology workshop to identify the current barriers and research needs of the H2@Scale concept. H2@Scale is a concept regarding the potential for wide-scale impact of hydrogen produced from diverse domestic resources to enhance U.S. energy security and enable growth of innovative technologies and domestic industries. Feedback received from a diverse set of stakeholders at the workshop will guide the development of an H2@Scale roadmap for research, development, and early stagemore » demonstration activities that can enable hydrogen as an energy carrier at a national scale.« less
Finnish cytotechnologists' views on the competencies of newly graduated biomedical scientists in clinical cytology.

PubMed

Liikanen, E

2018-02-01

This study asked 40 cytotechnologists for their views on the competencies of newly graduated biomedical scientists in clinical cytology during the national conference of the Finnish Association of Cytotechnologists in November 2015. The questionnaire mainly consisted of statements that were scored on a five-point Likert-scale, where 1 was not important and 5 was very important. It covered five sections of clinical cytology: sampling and techniques, gynaecological screening, non-gynaecological screening, safety and quality management, and miscellaneous. Of the 40 delegates approached to complete the questionnaire, 37 (92.5%) agreed. Respondents felt that important sampling and technique competencies were specimen fixation, with a mean score of 4.9 out of 5.0, types of specimens (4.7), Papanicolaou smear collection (4.7), Papanicolaou smear request information (4.7) and evaluation of specimen sufficiency (4.6). Less important competencies were examining FNAs (2.0) and nasopharyngeal specimens (2.2). The respondents had many expectations about how education in cytology could be developed, for example more theoretical lessons, more practice in microscope use, and consistent criteria for training and cooperation between cytology laboratories and universities of applied sciences. The cytotechnologists who took part in our survey expected newly graduated biomedical scientists to have basic competencies in cytology. These were sampling and techniques, laboratory safety and quality management, specimen adequacy and identifying normal cells taken during gynaecological screening. They were also keen to develop education in cytology. © 2017 John Wiley & Sons Ltd.
Two LANL laboratory astrophysics experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Intrator, Thomas P.

2014-01-24

Two laboratory experiments are described that have been built at Los Alamos (LANL) to gain access to a wide range of fundamental plasma physics issues germane to astro, space, and fusion plasmas. The overarching theme is magnetized plasma dynamics which includes significant currents, MHD forces and instabilities, magnetic field creation and annihilation, sheared flows and shocks. The Relaxation Scaling Experiment (RSX) creates current sheets and flux ropes that exhibit fully 3D dynamics, and can kink, bounce, merge and reconnect, shred, and reform in complicated ways. Recent movies from a large data set describe the 3D magnetic structure of a drivenmore » and dissipative single flux rope that spontaneously self-saturates a kink instability. Examples of a coherent shear flow dynamo driven by colliding flux ropes will also be shown. The Magnetized Shock Experiment (MSX) uses Field reversed configuration (FRC) experimental hardware that forms and ejects FRCs at 150km/sec. This is sufficient to drive a collision less magnetized shock when stagnated into a mirror stopping field region with Alfven Mach number MA=3 so that super critical shocks can be studied. We are building a plasmoid accelerator to drive Mach numbers MA >> 3 to access solar wind and more exotic astrophysical regimes. Unique features of this experiment include access to parallel, oblique and perpendicular shocks, shock region much larger than ion gyro radii and ion inertial length, room for turbulence, and large magnetic and fluid Reynolds numbers.« less
Performance of a passively vented field-scale biofilter for the microbial oxidation of landfill methane.

PubMed

Gebert, J; Gröngröft, A

2006-01-01

An upflow biofilter system was operated on a passively vented landfill for the treatment of residual landfill methane. Biofilter methane emissions as a basis for determining methane removal rates were assessed by manual and automated chamber measurements, by measuring methane concentrations in the top layer gaseous phase in combination with gas flow rates, and by evaluating the methane load in the reverse gas flow following the change of landfill gas flux direction as governed by the course of barometric pressure. Methane removal rates were very high with maximum values of 80 g h(-1) m(-3). For the observed cases, the limit of biofilter methane oxidation capacity was not reached and absolute removal rates were thus linearly correlated to the amount of methane entering the filter. The analysis of methane loads flowing back from the biofilter following phases of longer, continuous and non-oscillating landfill gas emission, however, revealed that in these situations biofilter performance is restricted by deficient oxygen supply. At the oxygen-restricted capacity limit, removal rates are influenced by temperature (positively), methane influx (negatively) and flow rate (negatively) as a measure for the displacement of oxygen. These situations, however, account for only 12% of all emission phases. The investigated biofilter capacity, as derived from laboratory analyses of methanotrophic activities, is sufficient to oxidise 62% of the methane load emitted annually. Field and laboratory data provide a stable basis for the dimensioning of filters in future applications.
Neocortical dynamics due to axon propagation delays in cortico-cortical fibers: EEG traveling and standing waves with implications for top-down influences on local networks and white matter disease

PubMed Central

Nunez, Paul L.; Srinivasan, Ramesh

2013-01-01

The brain is treated as a nested hierarchical complex system with substantial interactions across spatial scales. Local networks are pictured as embedded within global fields of synaptic action and action potentials. Global fields may act top-down on multiple networks, acting to bind remote networks. Because of scale-dependent properties, experimental electrophysiology requires both local and global models that match observational scales. Multiple local alpha rhythms are embedded in a global alpha rhythm. Global models are outlined in which cm-scale dynamic behaviors result largely from propagation delays in cortico-cortical axons and cortical background excitation level, controlled by neuromodulators on long time scales. The idealized global models ignore the bottom-up influences of local networks on global fields so as to employ relatively simple mathematics. The resulting models are transparently related to several EEG and steady state visually evoked potentials correlated with cognitive states, including estimates of neocortical coherence structure, traveling waves, and standing waves. The global models suggest that global oscillatory behavior of self-sustained (limit-cycle) modes lower than about 20 Hz may easily occur in neocortical/white matter systems provided: Background cortical excitability is sufficiently high; the strength of long cortico-cortical axon systems is sufficiently high; and the bottom-up influence of local networks on the global dynamic field is sufficiently weak. The global models provide "entry points" to more detailed studies of global top-down influences, including binding of weakly connected networks, modulation of gamma oscillations by theta or alpha rhythms, and the effects of white matter deficits. PMID:24505628

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Sample records for undergone sufficient laboratory-scale

Abstract