Sample records for underlying event activity
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Sirunyan, Albert M; et al.
This paper presents a measurement of the underlying event activity in proton-proton collisions at a center-of-mass energy of 13 TeV, performed using inclusive Z boson production events collected with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 2.1 fbmore » $$^{-1}$$. The underlying event activity is quantified in terms of the charged particle multiplicity, as well as of the scalar sum of the charged particles' transverse momenta in different topological regions defined with respect to the Z boson direction. The distributions are unfolded to the stable particle level and compared with predictions from various Monte Carlo event generators, as well as with similar CDF and CMS measurements at center-of-mass energies of 1.96 and 7 TeV respectively.« less
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-28
....282(a)(1)(i) through (a)(1)(iii)). In the event that an article of food has been refused admission... in a request for review. In the event that an article of food has been placed under hold under...] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment...
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The Effect of Interruptions on Part 121 Air Carrier Operations
NASA Technical Reports Server (NTRS)
Damos, Diane L.
1998-01-01
The primary purpose of this study was to determine the relative priorities of various events and activities by examining the probability that a given activity was interrupted by a given event. The analysis will begin by providing frequency of interruption data by crew position (captain versus first officer) and event type. Any differences in the pattern of interruptions between the first officers and the captains will be explored and interpreted in terms of standard operating procedures. Subsequent data analyses will focus on comparing the frequency of interruptions for different types of activities and for the same activities under normal versus emergency conditions. Briefings and checklists will receive particular attention. The frequency with which specific activities are interrupted under multiple- versus single-task conditions also will be examined; because the majority of multiple-task data were obtained under laboratory conditions, LOFT-type tapes offer a unique opportunity to examine concurrent task performance under 'real-world' conditions. A second purpose of this study is to examine the effects of the interruptions on performance. More specifically, when possible, the time to resume specific activities will be compared to determine if pilots are slower to resume certain types of activities. Errors in resumption or failures to resume specific activities will be noted and any patterns in these errors will be identified. Again, particular attention will be given to the effects of interruptions on the completion of checklists and briefings. Other types of errors and missed events (i.e., the crew should have responded to the event but did not) will be examined. Any methodology using interruptions to examine task prioritization must be able to identify when an interruption has occurred and describe the ongoing activities that were interrupted. Both of these methodological problems are discussed In detail in the following section,
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29 CFR 4043.23 - Active participant reduction.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 29 Labor 9 2012-07-01 2012-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at the...
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29 CFR 4043.23 - Active participant reduction.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 29 Labor 9 2013-07-01 2013-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at the...
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29 CFR 4043.23 - Active participant reduction.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 29 Labor 9 2011-07-01 2011-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at the...
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29 CFR 4043.23 - Active participant reduction.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 29 Labor 9 2014-07-01 2014-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at the...
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29 CFR 4043.23 - Active participant reduction.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 9 2010-07-01 2010-07-01 false Active participant reduction. 4043.23 Section 4043.23 Labor... Active participant reduction. (a) Reportable event. A reportable event occurs when the number of active participants under a plan is reduced to less than 80 percent of the number of active participants at the...
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NASA Technical Reports Server (NTRS)
Sakimoto, Philip (Editor)
2000-01-01
This Annual Report is a summary of nearly 400 Education and Public Outreach (E/PO) products and activities developed or carried out in FY2000 under NASA's Office of Space Science (OSS) E/PO program. It includes products and activities developed by OSS missions and research programs, innovative space science concepts developed under the Initiative to Develop Education through Astronomy and Space Science (IDEAS) Program, projects initiated under the Minority University Education and Research Partnership Initiative in Space Science, and a number of additional comprehensive or special purpose programs managed by OSS at NASA Headquarters. Taking into account the fact that many of the activities reported involve multiple events that took place in a variety of venues, the total number of E/PO events reported for FY2000 is over 1,500, with events having taken place in all 50 states, the District of Columbia, one US Territory (Guam), and four foreign nations (Australia, Canada, Mexico, and Peru).
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Air pollution exposure is associated with cardiovascular events triggered by clot formation. Endothelial activation and initiation of coagulation are pathophysiological mechanisms that could link inhaled air pollutants to vascular events. Here we investigated the underlying mecha...
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NASA Astrophysics Data System (ADS)
Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; de Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; Ochesanu, S.; Rougny, R.; van de Klundert, M.; van Haevermaet, H.; van Mechelen, P.; van Remortel, N.; van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; de Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; van Doninck, W.; van Mulders, P.; van Onsem, G. P.; van Parijs, I.; Barria, P.; Caillol, C.; Clerbaux, B.; de Lentdecker, G.; Delannoy, H.; Dobur, D.; Fasanella, G.; Favart, L.; Gay, A. P. R.; Grebenyuk, A.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Mohammadi, A.; Perniè, L.; Randle-Conde, A.; Reis, T.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Wang, J.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Fagot, A.; Garcia, G.; Gul, M.; McCartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Strobbe, N.; Tytgat, M.; van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Caebergs, T.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Dos Reis Martins, T.; Hensel, C.; Mora Herrera, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; da Costa, E. M.; de Jesus Damiao, D.; de Oliveira Martins, C.; Fonseca de Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; de Souza Santos, A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Genchev, V.; Hadjiiska, R.; Iaydjiev, P.; Marinov, A.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Zou, W.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Bodlak, M.; Finger, M.; Finger, M.; Aly, R.; Aly, S.; Assran, Y.; Elgammal, S.; Ellithi Kamel, A.; Lotfy, A.; Mahmoud, M. A.; Radi, A.; Sayed, A.; Calpas, B.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Dahms, T.; Davignon, O.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Lisniak, S.; Mastrolorenzo, L.; Miné, P.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Le Bihan, A.-C.; Merlin, J. A.; Skovpen, K.; van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Bouvier, E.; Brochet, S.; Carrillo Montoya, C. A.; Chasserat, J.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Ruiz Alvarez, J. D.; Sabes, D.; Sgandurra, L.; Sordini, V.; Donckt, M. Vander; Verdier, P.; Viret, S.; Xiao, H.; Toriashvili, T.; Bagaturia, I.; Autermann, C.; Beranek, S.; Edelhoff, M.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Sammet, J.; Schael, S.; Schulte, J. F.; Verlage, T.; Weber, H.; Wittmer, B.; Zhukov, V.; Ata, M.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Klingebiel, D.; Knutzen, S.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Millet, P.; Olschewski, M.; Padeken, K.; Papacz, P.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Künsken, A.; Lingemann, J.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Asin, I.; Bartosik, N.; Behnke, O.; Behrens, U.; Bell, A. J.; Borras, K.; Burgmeier, A.; Cakir, A.; Calligaris, L.; Campbell, A.; Choudhury, S.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Dooling, S.; Dorland, T.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Flucke, G.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Gunnellini, P.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Katsas, P.; Kieseler, J.; Kleinwort, C.; Korol, I.; Lange, W.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Marfin, I.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Nayak, A.; Ntomari, E.; Perrey, H.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Ribeiro Cipriano, P. M.; Roland, B.; Sahin, M. Ö.; Salfeld-Nebgen, J.; Saxena, P.; Schoerner-Sadenius, T.; Schröder, M.; Seitz, C.; Spannagel, S.; Trippkewitz, K. D.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Erfle, J.; Garutti, E.; Goebel, K.; Gonzalez, D.; Görner, M.; Haller, J.; Hoffmann, M.; Höing, R. S.; Junkes, A.; Klanner, R.; Kogler, R.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Nowatschin, D.; Ott, J.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Pietsch, N.; Poehlsen, J.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schwandt, J.; Seidel, M.; Sola, V.; Stadie, H.; Steinbrück, G.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Akbiyik, M.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; Colombo, F.; de Boer, W.; Descroix, A.; Dierlamm, A.; Feindt, M.; Frensch, F.; Giffels, M.; Gilbert, A.; Hartmann, F.; Husemann, U.; Kassel, F.; Katkov, I.; Kornmayer, A.; Lobelle Pardo, P.; Mozer, M. U.; Müller, T.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weiler, T.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Markou, A.; Psallidas, A.; Topsis-Giotis, I.; Agapitos, A.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Bencze, G.; Hajdu, C.; Hazi, A.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Szillasi, Z.; Bartók, M.; Makovec, A.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Mal, P.; Mandal, K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Gupta, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Nishu, N.; Singh, J. B.; Walia, G.; Kumar, Ashok; Kumar, Arun; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Ranjan, K.; Sharma, R.; Sharma, V.; Banerjee, S.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutta, S.; Jain, Sa.; Jain, Sh.; Khurana, R.; Majumdar, N.; Modak, A.; Mondal, K.; Mukherjee, S.; Mukhopadhyay, S.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Abdulsalam, A.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, S.; Bhowmik, S.; Chatterjee, R. M.; Dewanjee, R. K.; Dugad, S.; Ganguly, S.; Ghosh, S.; Guchait, M.; Gurtu, A.; Kole, G.; Kumar, S.; Mahakud, B.; Maity, M.; Majumder, G.; Mazumdar, K.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sarkar, T.; Sudhakar, K.; Sur, N.; Sutar, B.; Wickramage, N.; Sharma, S.; Bakhshiansohi, H.; Behnamian, H.; Etesami, S. M.; Fahim, A.; Goldouzian, R.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Chhibra, S. S.; Colaleo, A.; Creanza, D.; Cristella, L.; de Filippis, N.; de Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Cappello, G.; Chiorboli, M.; Costa, S.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gonzi, S.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Calvelli, V.; Ferro, F.; Lo Vetere, M.; Robutti, E.; Tosi, S.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Malvezzi, S.; Manzoni, R. A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; di Guida, S.; Esposito, M.; Fabozzi, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Bellato, M.; Bisello, D.; Carlin, R.; Carvalho Antunes de Oliveira, A.; Checchia, P.; Dall'Osso, M.; Dorigo, T.; Fantinel, S.; Fanzago, F.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Tosi, M.; Zanetti, M.; Zotto, P.; Zucchetta, A.; Zumerle, G.; Braghieri, A.; Gabusi, M.; Magnani, A.; Ratti, S. P.; Re, V.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Alunni Solestizi, L.; Biasini, M.; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Mantovani, G.; Menichelli, M.; Saha, A.; Santocchia, A.; Spiezia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Foà, L.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Serban, A. T.; Spagnolo, P.; Squillacioti, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; D'Imperio, G.; Del Re, D.; Diemoz, M.; Gelli, S.; Jorda, C.; Longo, E.; Margaroli, F.; Meridiani, P.; Micheli, F.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Traczyk, P.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bellan, R.; Biino, C.; Cartiglia, N.; Costa, M.; Covarelli, R.; Degano, A.; Dellacasa, G.; Demaria, N.; Finco, L.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Musich, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Tamponi, U.; Belforte, S.; Candelise, V.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; La Licata, C.; Marone, M.; Schizzi, A.; Umer, T.; Zanetti, A.; Chang, S.; Kropivnitskaya, A.; Nam, S. K.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Kong, D. J.; Lee, S.; Oh, Y. D.; Sakharov, A.; Son, D. C.; Brochero Cifuentes, J. A.; Kim, H.; Kim, T. J.; Ryu, M. S.; Song, S.; Choi, S.; Go, Y.; Gyun, D.; Hong, B.; Jo, M.; Kim, H.; Kim, Y.; Lee, B.; Lee, K.; Lee, K. S.; Lee, S.; Park, S. K.; Roh, Y.; Yoo, H. D.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Choi, Y.; Choi, Y. K.; Goh, J.; Kim, D.; Kwon, E.; Lee, J.; Yu, I.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Komaragiri, J. R.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Casimiro Linares, E.; Castilla-Valdez, H.; de La Cruz-Burelo, E.; Heredia-de La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Vazquez Valencia, F.; Carpinteyro, S.; Pedraza, I.; Salazar Ibarguen, H. A.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Reucroft, S.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Khurshid, T.; Shoaib, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Brona, G.; Bunkowski, K.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Walczak, M.; Bargassa, P.; Beirão da Cruz E Silva, C.; di Francesco, A.; Faccioli, P.; Ferreira Parracho, P. 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V.; Vinogradov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Dudko, L.; Ershov, A.; Gribushin, A.; Khein, L.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Myagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Snigirev, A.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Ekmedzic, M.; Milosevic, J.; Rekovic, V.; Wang, W. Y.; Alcaraz Maestre, J.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; de La Cruz, B.; Delgado Peris, A.; Domínguez Vázquez, D.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro de Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; Albajar, C.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Brun, H.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Palencia Cortezon, E.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras de Saa, J. R.; de Castro Manzano, P.; Duarte Campderros, J.; Fernandez, M.; Gomez, G.; Graziano, A.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Piedra Gomez, J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benaglia, A.; Bendavid, J.; Benhabib, L.; Benitez, J. F.; Berruti, G. 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V.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Piparo, D.; Racz, A.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Sharma, A.; Silva, P.; Simon, M.; Sphicas, P.; Spiga, D.; Steggemann, J.; Stieger, B.; Stoye, M.; Takahashi, Y.; Treille, D.; Tsirou, A.; Veres, G. I.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Buchmann, M. A.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dünser, M.; Eller, P.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marini, A. C.; Marionneau, M.; Martinez Ruiz Del Arbol, P.; Masciovecchio, M.; Meister, D.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrozzi, L.; Peruzzi, M.; Quittnat, M.; Rossini, M.; Starodumov, A.; Takahashi, M.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Weber, H. A.; Aarrestad, T. K.; Amsler, C.; Canelli, M. F.; Chiochia, V.; de Cosa, A.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Lange, C.; Ngadiuba, J.; Pinna, D.; Robmann, P.; Ronga, F. J.; Salerno, D.; Taroni, S.; Yang, Y.; Cardaci, M.; Chen, K. H.; Doan, T. H.; Ferro, C.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Lu, Y. J.; Volpe, R.; Yu, S. S.; Bartek, R.; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Chen, P. H.; Dietz, C.; Fiori, F.; Grundler, U.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Miñano Moya, M.; Petrakou, E.; Tsai, J. F.; Tzeng, Y. M.; Asavapibhop, B.; Kovitanggoon, K.; Singh, G.; Srimanobhas, N.; Suwonjandee, N.; Adiguzel, A.; Cerci, S.; Dozen, C.; Girgis, S.; Gokbulut, G.; Guler, Y.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Kayis Topaksu, A.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Tali, B.; Topakli, H.; Vergili, M.; Zorbilmez, C.; Akin, I. V.; Bilin, B.; Bilmis, S.; Isildak, B.; Karapinar, G.; Surat, U. E.; Yalvac, M.; Zeyrek, M.; Albayrak, E. A.; Gülmez, E.; Kaya, M.; Kaya, O.; Yetkin, T.; Cankocak, K.; Sen, S.; Vardarlı, F. I.; Grynyov, B.; Levchuk, L.; Sorokin, P.; Aggleton, R.; Ball, F.; Beck, L.; Brooke, J. J.; Clement, E.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Meng, Z.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Sakuma, T.; Seif El Nasr-Storey, S.; Senkin, S.; Smith, D.; Smith, V. J.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Thomas, L.; Tomalin, I. R.; Williams, T.; Womersley, W. J.; Worm, S. D.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Bundock, A.; Burton, D.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Cripps, N.; Dauncey, P.; Davies, G.; de Wit, A.; Della Negra, M.; Dunne, P.; Elwood, A.; Ferguson, W.; Fulcher, J.; Futyan, D.; Hall, G.; Iles, G.; Karapostoli, G.; Kenzie, M.; Lane, R.; Lucas, R.; Lyons, L.; Magnan, A.-M.; Malik, S.; Nash, J.; Nikitenko, A.; Pela, J.; Pesaresi, M.; Petridis, K.; Raymond, D. M.; Richards, A.; Rose, A.; Seez, C.; Sharp, P.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leggat, D.; Leslie, D.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Dittmann, J.; Hatakeyama, K.; Kasmi, A.; Liu, H.; Pastika, N.; Charaf, O.; Cooper, S. I.; Henderson, C.; Rumerio, P.; Avetisyan, A.; Bose, T.; Fantasia, C.; Gastler, D.; Lawson, P.; Rankin, D.; Richardson, C.; Rohlf, J.; St. John, J.; Sulak, L.; Zou, D.; Alimena, J.; Berry, E.; Bhattacharya, S.; Cutts, D.; Dhingra, N.; Ferapontov, A.; Garabedian, A.; Heintz, U.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Sagir, S.; Sinthuprasith, T.; Breedon, R.; Breto, G.; Calderon de La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Gardner, M.; Ko, W.; Lander, R.; Mulhearn, M.; Pellett, D.; Pilot, J.; Ricci-Tam, F.; Shalhout, S.; Smith, J.; Squires, M.; Stolp, D.; Tripathi, M.; Wilbur, S.; Yohay, R.; Cousins, R.; Everaerts, P.; Farrell, C.; Hauser, J.; Ignatenko, M.; Rakness, G.; Saltzberg, D.; Takasugi, E.; Valuev, V.; Weber, M.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Hanson, G.; Heilman, J.; Ivova Paneva, M.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Luthra, A.; Malberti, M.; Olmedo Negrete, M.; Shrinivas, A.; Sumowidagdo, S.; Wei, H.; Wimpenny, S.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; D'Agnolo, R. T.; Holzner, A.; Kelley, R.; Klein, D.; Letts, J.; MacNeill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Tu, Y.; Vartak, A.; Wasserbaech, S.; Welke, C.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Barge, D.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Flowers, K.; Franco Sevilla, M.; Geffert, P.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Incandela, J.; Justus, C.; McColl, N.; Mullin, S. D.; Richman, J.; Stuart, D.; Suarez, I.; To, W.; West, C.; Yoo, J.; Anderson, D.; Apresyan, A.; Bornheim, A.; Bunn, J.; Chen, Y.; Duarte, J.; Mott, A.; Newman, H. B.; Pena, C.; Pierini, M.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Azzolini, V.; Calamba, A.; Carlson, B.; Ferguson, T.; Iiyama, Y.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Ford, W. T.; Gaz, A.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Nauenberg, U.; Smith, J. G.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Chaves, J.; Chu, J.; Dittmer, S.; Eggert, N.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Sun, W.; Tan, S. M.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Weng, Y.; Wittich, P.; Abdullin, S.; Albrow, M.; Anderson, J.; Apollinari, G.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Hare, D.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; Hu, Z.; Jindariani, S.; Johnson, M.; Joshi, U.; Jung, A. W.; Klima, B.; Kreis, B.; Kwan, S.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lopes de Sá, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Martinez Outschoorn, V. I.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mishra, K.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Prokofyev, O.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Whitbeck, A.; Yang, F.; Yin, H.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; di Giovanni, G. P.; Field, R. D.; Fisher, M.; Furic, I. K.; Hugon, J.; Konigsberg, J.; Korytov, A.; Low, J. F.; Ma, P.; Matchev, K.; Mei, H.; Milenovic, P.; Mitselmakher, G.; Muniz, L.; Rank, D.; Shchutska, L.; Snowball, M.; Sperka, D.; Wang, S.; Yelton, J.; Hewamanage, S.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bochenek, J.; Diamond, B.; Haas, J.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Veeraraghavan, V.; Weinberg, M.; Bhopatkar, V.; Hohlmann, M.; Kalakhety, H.; Mareskas-Palcek, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Silkworth, C.; Turner, P.; Varelas, N.; Wu, Z.; Zakaria, M.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tan, P.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Barnett, B. A.; Blumenfeld, B.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Nash, K.; Osherson, M.; Swartz, M.; Xiao, M.; Xin, Y.; Baringer, P.; Bean, A.; Benelli, G.; Bruner, C.; Gray, J.; Kenny, R. P.; Majumder, D.; Malek, M.; Murray, M.; Noonan, D.; Sanders, S.; Stringer, R.; Wang, Q.; Wood, J. S.; Chakaberia, I.; Ivanov, A.; Kaadze, K.; Khalil, S.; Makouski, M.; Maravin, Y.; Saini, L. K.; Skhirtladze, N.; Svintradze, I.; Toda, S.; Lange, D.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Pedro, K.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Apyan, A.; Barbieri, R.; Baty, A.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Gomez Ceballos, G.; Goncharov, M.; Gulhan, D.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; McGinn, C.; Niu, X.; Paus, C.; Ralph, D.; Roland, C.; Roland, G.; Stephans, G. S. F.; Sumorok, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Dahmes, B.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Bose, S.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Keller, J.; Knowlton, D.; Kravchenko, I.; Lazo-Flores, J.; Meier, F.; Monroy, J.; Ratnikov, F.; Siado, J. E.; Snow, G. R.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Rappoccio, S.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira de Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Zhang, J.; Hahn, K. A.; Kubik, A.; Mucia, N.; Odell, N.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Sung, K.; Trovato, M.; Velasco, M.; Won, S.; Brinkerhoff, A.; Dev, N.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Lynch, S.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Pearson, T.; Planer, M.; Ruchti, R.; Smith, G.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hart, A.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Liu, B.; Luo, W.; Puigh, D.; Rodenburg, M.; Winer, B. L.; Wulsin, H. W.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Malik, S.; Barnes, V. E.; Benedetti, D.; Bortoletto, D.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Leonardo, N.; Miller, D. H.; Neumeister, N.; Primavera, F.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Zablocki, J.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Hindrichs, O.; Khukhunaishvili, A.; Petrillo, G.; Verzetti, M.; Demortier, L.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Lath, A.; Panwalkar, S.; Park, M.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Riley, G.; Rose, K.; Spanier, S.; York, A.; Bouhali, O.; Castaneda Hernandez, A.; Dalchenko, M.; de Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Krutelyov, V.; Montalvo, R.; Mueller, R.; Osipenkov, I.; Pakhotin, Y.; Patel, R.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Undleeb, S.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wolfe, E.; Wood, J.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Christian, A.; Dasu, S.; Dodd, L.; Duric, S.; Friis, E.; Gomber, B.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Ruggles, T.; Sarangi, T.; Savin, A.; Sharma, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.
2015-09-01
A measurement of the underlying event (UE) activity in proton-proton collisions is performed using events with charged-particle jets produced in the central pseudorapidity region (| η jet| < 2) and with transverse momentum 1 ≤ p T jet < 100 GeV. The analysis uses a data sample collected at a centre-of-mass energy of 2.76 TeV with the CMS experiment at the LHC. The UE activity is measured as a function of p T jet in terms of the average multiplicity and scalar sum of transverse momenta ( p T) of charged particles, with | η| < 2 and p T > 0.5 GeV, in the azimuthal region transverse to the highest p T jet direction. By further dividing the transverse region into two regions of smaller and larger activity, various components of the UE activity are separated. The measurements are compared to previous results at 0.9 and 7 TeV, and to predictions of several Monte Carlo event generators, providing constraints on the modelling of the UE dynamics. [Figure not available: see fulltext.
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Situation and person attributions under spontaneous and intentional instructions: an fMRI study
Kestemont, Jenny; Vandekerckhove, Marie; Ma, Ning; Van Hoeck, Nicole
2013-01-01
This functional magnetic resonance imaging (fMRI) research explores how observers make causal beliefs about an event in terms of the person or situation. Thirty-four participants read various short descriptions of social events that implied either the person or the situation as the cause. Half of them were explicitly instructed to judge whether the event was caused by something about the person or the situation (intentional inferences), whereas the other half was instructed simply to read the material carefully (spontaneous inferences). The results showed common activation in areas related to mentalizing, across all types of causes or instructions (posterior superior temporal sulcus, temporo-parietal junction, precuneus). However, the medial prefrontal cortex was activated only under spontaneous instructions, but not under intentional instruction. This suggests a bias toward person attributions (e.g. fundamental attribution bias). Complementary to this, intentional situation attributions activated a stronger and more extended network compared to intentional person attributions, suggesting that situation attributions require more controlled, extended and broader processing of the information. PMID:22345370
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Eberwein, Philipp; Laird, Dougal; Schulz, Simon; Reinhard, Thomas; Steinberg, Thorsten; Tomakidi, Pascal
2015-10-01
Within the concept of integrin growth factor receptor (GFR) cross-talk, little is known about the effects of GFRs on focal adhesions (FAs). Therefore, we tested the hypothesis whether EGF can modulate constituents of FAs and subsequent down-stream events. To this end, EGF-treated keratinocytes were subjected to combined fluorescence imaging and western blotting, to quantify expression and/or activation of molecules, involved in integrin GFR cross-talk, and receptor proximal and distal signaling events. Generally, EGF response revealed an amplified redistribution or activation of molecules under study, which will be explained in detail from the plasma membrane to the cell interior. In addition to significant activation of EGF receptor (EGFR) at tyrosine Tyr845, a remarkable redistribution was detectable for the focal adhesion constituents, integrin ß1 and ß3, and zyxin. Increased activation also applied to focal adhesion kinase (FAK) by phosphorylation at Tyr397, Tyr576, and Src at Tyr418, while total FAK remained unchanged. Risen activity was seen as well for the analyzed distal down-stream events, p190RhoGAP and MAP kinases p42/44. Intriguingly, Src-specific inhibitor Herbimycin A abrogated the entire EGF response except FAK Tyr397 phosphorylation, independent of EGF presence. Mechanistically, our results show that EGF modulates adhesion in a dual fashion, by firstly redistributing focal adhesion constituents to adhesion sites, but also by amplifying levels of activated RhoA antagonist p190RhoGAP, important for cell motility. Further, the findings suggest that the observed EGF response underlies an EGFR integrin cross-talk under recruitment of receptor proximal FAK and Src, and MAP kinase and p190RhoGAP as receptor distal events. Copyright © 2015 Elsevier B.V. All rights reserved.
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NASA Astrophysics Data System (ADS)
Aad, G.; Abbott, B.; Abdallah, J.; Abdelalim, A. A.; Abdesselam, A.; Abdinov, O.; Abi, B.; Abolins, M.; Abramowicz, H.; Abreu, H.; Acerbi, E.; Acharya, B. S.; Ackers, M.; Adams, D. L.; Addy, T. N.; Adelman, J.; Aderholz, M.; Adomeit, S.; Adragna, P.; Adye, T.; Aefsky, S.; Aguilar-Saavedra, J. A.; Aharrouche, M.; Ahlen, S. P.; Ahles, F.; Ahmad, A.; Ahmed, H.; Ahsan, M.; Aielli, G.; Akdogan, T.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Alam, M. S.; Alam, M. A.; Albrand, S.; Aleksa, M.; Aleksandrov, I. N.; Aleppo, M.; Alessandria, F.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Aliev, M.; Alimonti, G.; Alison, J.; Aliyev, M.; Allport, P. P.; Allwood-Spiers, S. E.; Almond, J.; Aloisio, A.; Alon, R.; Alonso, A.; Alonso, J.; Alviggi, M. G.; Amako, K.; Amaral, P.; Amelung, C.; Ammosov, V. V.; Amorim, A.; Amorós, G.; Amram, N.; Anastopoulos, C.; Andeen, T.; Anders, C. F.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Andrieux, M.-L.; Anduaga, X. 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K.; Ciftci, R.; Cinca, D.; Cindro, V.; Ciobotaru, M. D.; Ciocca, C.; Ciocio, A.; Cirilli, M.; Clark, A.; Clark, P. J.; Cleland, W.; Clemens, J. C.; Clement, B.; Clement, C.; Clifft, R. W.; Coadou, Y.; Cobal, M.; Coccaro, A.; Cochran, J.; Coe, P.; Cogan, J. G.; Coggeshall, J.; Cogneras, E.; Cojocaru, C. D.; Colas, J.; Colijn, A. P.; Collard, C.; Collins, N. J.; Collins-Tooth, C.; Collot, J.; Colon, G.; Coluccia, R.; Comune, G.; Conde Muiño, P.; Coniavitis, E.; Conidi, M. C.; Consonni, M.; Constantinescu, S.; Conta, C.; Conventi, F.; Cook, J.; Cooke, M.; Cooper, B. D.; Cooper-Sarkar, A. M.; Cooper-Smith, N. J.; Copic, K.; Cornelissen, T.; Corradi, M.; Correard, S.; Corriveau, F.; Cortes-Gonzalez, A.; Cortiana, G.; Costa, G.; Costa, M. J.; Costanzo, D.; Costin, T.; Côté, D.; Coura Torres, R.; Courneyea, L.; Cowan, G.; Cowden, C.; Cox, B. E.; Cranmer, K.; Cristinziani, M.; Crosetti, G.; Crupi, R.; Crépé-Renaudin, S.; Cuenca Almenar, C.; Cuhadar Donszelmann, T.; Cuneo, S.; Curatolo, M.; Curtis, C. J.; Cwetanski, P.; Czirr, H.; Czyczula, Z.; D'Auria, S.; D'Onofrio, M.; D'Orazio, A.; da Rocha Gesualdi Mello, A.; da Silva, P. V. M.; da Via, C.; Dabrowski, W.; Dahlhoff, A.; Dai, T.; Dallapiccola, C.; Dallison, S. J.; Dam, M.; Dameri, M.; Damiani, D. S.; Danielsson, H. O.; Dankers, R.; Dannheim, D.; Dao, V.; Darbo, G.; Darlea, G. L.; Daum, C.; Dauvergne, J. P.; Davey, W.; Davidek, T.; Davidson, N.; Davidson, R.; Davies, M.; Davison, A. R.; Dawe, E.; Dawson, I.; Dawson, J. W.; Daya, R. K.; de, K.; de Asmundis, R.; de Castro, S.; de Cecco, S.; de Graat, J.; de Groot, N.; de Jong, P.; de La Cruz-Burelo, E.; de La Taille, C.; de Lotto, B.; de Mora, L.; de Nooij, L.; de Oliveira Branco, M.; de Pedis, D.; de Saintignon, P.; de Salvo, A.; de Sanctis, U.; de Santo, A.; de Vivie de Regie, J. B.; Dean, S.; Dedes, G.; Dedovich, D. V.; Degenhardt, J.; Dehchar, M.; Deile, M.; Del Papa, C.; Del Peso, J.; Del Prete, T.; Dell'Acqua, A.; Dell'Asta, L.; Della Pietra, M.; Della Volpe, D.; Delmastro, M.; Delpierre, P.; Delruelle, N.; Delsart, P. A.; Deluca, C.; Demers, S.; Demichev, M.; Demirkoz, B.; Deng, J.; Denisov, S. P.; Dennis, C.; Derendarz, D.; Derkaoui, J. E.; Derue, F.; Dervan, P.; Desch, K.; Deviveiros, P. O.; Dewhurst, A.; Dewilde, B.; Dhaliwal, S.; Dhullipudi, R.; di Ciaccio, A.; di Ciaccio, L.; di Girolamo, A.; di Girolamo, B.; di Luise, S.; di Mattia, A.; di Nardo, R.; di Simone, A.; di Sipio, R.; Diaz, M. A.; Diaz Gomez, M. M.; Diblen, F.; Diehl, E. B.; Dietl, H.; Dietrich, J.; Dietzsch, T. A.; Diglio, S.; Dindar Yagci, K.; Dingfelder, J.; Dionisi, C.; Dita, P.; Dita, S.; Dittus, F.; Djama, F.; Djilkibaev, R.; Djobava, T.; Do Vale, M. A. B.; Do Valle Wemans, A.; Doan, T. K. O.; Dobbs, M.; Dobinson, R.; Dobos, D.; Dobson, E.; Dobson, M.; Dodd, J.; Dogan, O. B.; Doglioni, C.; Doherty, T.; Doi, Y.; Dolejsi, J.; Dolenc, I.; Dolezal, Z.; Dolgoshein, B. A.; Dohmae, T.; Donadelli, M.; Donega, M.; Donini, J.; Dopke, J.; Doria, A.; Dos Anjos, A.; Dosil, M.; Dotti, A.; Dova, M. T.; Dowell, J. D.; Doxiadis, A. D.; Doyle, A. T.; Drasal, Z.; Drees, J.; Dressnandt, N.; Drevermann, H.; Driouichi, C.; Dris, M.; Drohan, J. G.; Dubbert, J.; Dubbs, T.; Dube, S.; Duchovni, E.; Duckeck, G.; Dudarev, A.; Dudziak, F.; Dührssen, M.; Duerdoth, I. P.; Duflot, L.; Dufour, M.-A.; Dunford, M.; Duran Yildiz, H.; Duxfield, R.; Dwuznik, M.; Dydak, F.; Dzahini, D.; Düren, M.; Ebke, J.; Eckert, S.; Eckweiler, S.; Edmonds, K.; Edwards, C. 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R.; Gingrich, D. M.; Ginzburg, J.; Giokaris, N.; Giordano, R.; Giorgi, F. M.; Giovannini, P.; Giraud, P. F.; Giugni, D.; Giusti, P.; Gjelsten, B. K.; Gladilin, L. K.; Glasman, C.; Glatzer, J.; Glazov, A.; Glitza, K. W.; Glonti, G. L.; Godfrey, J.; Godlewski, J.; Goebel, M.; Göpfert, T.; Goeringer, C.; Gössling, C.; Göttfert, T.; Goldfarb, S.; Goldin, D.; Golling, T.; Gollub, N. P.; Golovnia, S. N.; Gomes, A.; Gomez Fajardo, L. S.; Gonçalo, R.; Gonella, L.; Gong, C.; Gonidec, A.; Gonzalez, S.; González de La Hoz, S.; Gonzalez Silva, M. L.; Gonzalez-Sevilla, S.; Goodson, J. J.; Goossens, L.; Gorbounov, P. A.; Gordon, H. A.; Gorelov, I.; Gorfine, G.; Gorini, B.; Gorini, E.; Gorišek, A.; Gornicki, E.; Gorokhov, S. A.; Gorski, B. T.; Goryachev, V. N.; Gosdzik, B.; Gosselink, M.; Gostkin, M. I.; Gouanère, M.; Gough Eschrich, I.; Gouighri, M.; Goujdami, D.; Goulette, M. P.; Goussiou, A. G.; Goy, C.; Grabowska-Bold, I.; Grabski, V.; Grafström, P.; Grah, C.; Grahn, K.-J.; Grancagnolo, F.; Grancagnolo, S.; Grassi, V.; Gratchev, V.; Grau, N.; Gray, H. M.; Gray, J. A.; Graziani, E.; Grebenyuk, O. G.; Greenfield, D.; Greenshaw, T.; Greenwood, Z. D.; Gregor, I. M.; Grenier, P.; Griesmayer, E.; Griffiths, J.; Grigalashvili, N.; Grillo, A. A.; Grimm, K.; Grinstein, S.; Grishkevich, Y. V.; Grivaz, J.-F.; Grognuz, J.; Groh, M.; Gross, E.; Grosse-Knetter, J.; Groth-Jensen, J.; Gruwe, M.; Grybel, K.; Guarino, V. J.; Guicheney, C.; Guida, A.; Guillemin, T.; Guindon, S.; Guler, H.; Gunther, J.; Guo, B.; Guo, J.; Gupta, A.; Gusakov, Y.; Gushchin, V. N.; Gutierrez, A.; Gutierrez, P.; Guttman, N.; Gutzwiller, O.; Guyot, C.; Gwenlan, C.; Gwilliam, C. B.; Haas, A.; Haas, S.; Haber, C.; Hackenburg, R.; Hadavand, H. K.; Hadley, D. R.; Haefner, P.; Härtel, R.; Hahn, F.; Haider, S.; Hajduk, Z.; Hakobyan, H.; Haller, J.; Hamacher, K.; Hamilton, A.; Hamilton, S.; Han, H.; Han, L.; Hanagaki, K.; Hance, M.; Handel, C.; Hanke, P.; Hansen, C. J.; Hansen, J. R.; Hansen, J. B.; Hansen, J. D.; Hansen, P. H.; Hansson, P.; Hara, K.; Hare, G. A.; Harenberg, T.; Harper, D.; Harper, R.; Harrington, R. D.; Harris, O. M.; Harrison, K.; Hart, J. C.; Hartert, J.; Hartjes, F.; Haruyama, T.; Harvey, A.; Hasegawa, S.; Hasegawa, Y.; Hassani, S.; Hatch, M.; Hauff, D.; Haug, S.; Hauschild, M.; Hauser, R.; Havranek, M.; Hawes, B. M.; Hawkes, C. M.; Hawkings, R. J.; Hawkins, D.; Hayakawa, T.; Hayward, H. S.; Haywood, S. J.; Hazen, E.; He, M.; Head, S. J.; Hedberg, V.; Heelan, L.; Heim, S.; Heinemann, B.; Heisterkamp, S.; Helary, L.; Heldmann, M.; Heller, M.; Hellman, S.; Helsens, C.; Henderson, R. C. W.; Hendriks, P. J.; Henke, M.; Henrichs, A.; Henriques Correia, A. 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V.; Poblaguev, A.; Poddar, S.; Podlyski, F.; Poggioli, L.; Poghosyan, T.; Pohl, M.; Polci, F.; Polesello, G.; Policicchio, A.; Polini, A.; Poll, J.; Polychronakos, V.; Pomarede, D. M.; Pomeroy, D.; Pommès, K.; Pontecorvo, L.; Pope, B. G.; Popeneciu, G. A.; Popovic, D. S.; Poppleton, A.; Portell Bueso, X.; Porter, R.; Posch, C.; Pospelov, G. E.; Pospisil, S.; Potrap, I. N.; Potter, C. J.; Potter, C. T.; Poulard, G.; Poveda, J.; Prabhu, R.; Pralavorio, P.; Prasad, S.; Pravahan, R.; Prell, S.; Pretzl, K.; Pribyl, L.; Price, D.; Price, L. E.; Price, M. J.; Prichard, P. M.; Prieur, D.; Primavera, M.; Prokofiev, K.; Prokoshin, F.; Protopopescu, S.; Proudfoot, J.; Prudent, X.; Przysiezniak, H.; Psoroulas, S.; Ptacek, E.; Purdham, J.; Purohit, M.; Puzo, P.; Pylypchenko, Y.; Qian, J.; Qian, Z.; Qin, Z.; Quadt, A.; Quarrie, D. R.; Quayle, W. B.; Quinonez, F.; Raas, M.; Radescu, V.; Radics, B.; Rador, T.; Ragusa, F.; Rahal, G.; Rahimi, A. M.; Rajagopalan, S.; Rajek, S.; Rammensee, M.; Rammes, M.; Ramstedt, M.; Randrianarivony, K.; Ratoff, P. N.; Rauscher, F.; Rauter, E.; Raymond, M.; Read, A. L.; Rebuzzi, D. M.; Redelbach, A.; Redlinger, G.; Reece, R.; Reeves, K.; Reichold, A.; Reinherz-Aronis, E.; Reinsch, A.; Reisinger, I.; Reljic, D.; Rembser, C.; Ren, Z. L.; Renkel, P.; Rensch, B.; Rescigno, M.; Resconi, S.; Resende, B.; Reznicek, P.; Rezvani, R.; Richards, A.; Richter, R.; Richter-Was, E.; Ridel, M.; Rieke, S.; Rijpstra, M.; Rijssenbeek, M.; Rimoldi, A.; Rinaldi, L.; Rios, R. R.; Riu, I.; Rivoltella, G.; Rizatdinova, F.; Rizvi, E.; Roa Romero, D. A.; Robertson, S. H.; Robichaud-Veronneau, A.; Robinson, D.; Robinson, J. E. M.; Robinson, M.; Robson, A.; Rocha de Lima, J. G.; Roda, C.; Roda Dos Santos, D.; Rodier, S.; Rodriguez, D.; Rodriguez Garcia, Y.; Roe, A.; Roe, S.; Røhne, O.; Rojo, V.; Rolli, S.; Romaniouk, A.; Romanov, V. M.; Romeo, G.; Romero Maltrana, D.; Roos, L.; Ros, E.; Rosati, S.; Rose, M.; Rosenbaum, G. A.; Rosenberg, E. I.; Rosendahl, P. L.; Rosselet, L.; Rossetti, V.; Rossi, E.; Rossi, L. P.; Rossi, L.; Rotaru, M.; Roth, I.; Rothberg, J.; Rottländer, I.; Rousseau, D.; Royon, C. R.; Rozanov, A.; Rozen, Y.; Ruan, X.; Rubinskiy, I.; Ruckert, B.; Ruckstuhl, N.; Rud, V. I.; Rudolph, G.; Rühr, F.; Ruggieri, F.; Ruiz-Martinez, A.; Rulikowska-Zarebska, E.; Rumiantsev, V.; Rumyantsev, L.; Runge, K.; Runolfsson, O.; Rurikova, Z.; Rusakovich, N. A.; Rust, D. R.; Rutherfoord, J. P.; Ruwiedel, C.; Ruzicka, P.; Ryabov, Y. F.; Ryadovikov, V.; Ryan, P.; Rybkin, G.; Ryder, N. C.; Rzaeva, S.; Saavedra, A. F.; Sadeh, I.; Sadrozinski, H. F.-W.; Sadykov, R.; Safai Tehrani, F.; Sakamoto, H.; Salamanna, G.; Salamon, A.; Saleem, M.; Salihagic, D.; Salnikov, A.; Salt, J.; Salvachua Ferrando, B. M.; Salvatore, D.; Salvatore, F.; Salvucci, A.; Salzburger, A.; Sampsonidis, D.; Samset, B. H.; Sandaker, H.; Sander, H. G.; Sanders, M. P.; Sandhoff, M.; Sandhu, P.; Sandoval, T.; Sandstroem, R.; Sandvoss, S.; Sankey, D. P. C.; Sansoni, A.; Santamarina Rios, C.; Santoni, C.; Santonico, R.; Santos, H.; Saraiva, J. G.; Sarangi, T.; Sarkisyan-Grinbaum, E.; Sarri, F.; Sartisohn, G.; Sasaki, O.; Sasaki, T.; Sasao, N.; Satsounkevitch, I.; Sauvage, G.; Savard, P.; Savinov, V.; Savva, P.; Sawyer, L.; Saxon, D. H.; Says, L. P.; Sbarra, C.; Sbrizzi, A.; Scallon, O.; Scannicchio, D. A.; Schaarschmidt, J.; Schacht, P.; Schäfer, U.; Schaetzel, S.; Schaffer, A. C.; Schaile, D.; Schamberger, R. D.; Schamov, A. G.; Scharf, V.; Schegelsky, V. A.; Scheirich, D.; Scherzer, M. I.; Schiavi, C.; Schieck, J.; Schioppa, M.; Schlenker, S.; Schlereth, J. L.; Schmidt, E.; Schmidt, M. P.; Schmieden, K.; Schmitt, C.; Schmitz, M.; Schöning, A.; Schott, M.; Schouten, D.; Schovancova, J.; Schram, M.; Schreiner, A.; Schroeder, C.; Schroer, N.; Schroers, M.; Schuh, S.; Schuler, G.; Schultes, J.; Schultz-Coulon, H.-C.; Schumacher, J. W.; Schumacher, M.; Schumm, B. A.; Schune, Ph.; Schwanenberger, C.; Schwartzman, A.; Schweiger, D.; Schwemling, Ph.; Schwienhorst, R.; Schwierz, R.; Schwindling, J.; Scott, W. G.; Searcy, J.; Sedykh, E.; Segura, E.; Seidel, S. C.; Seiden, A.; Seifert, F.; Seixas, J. M.; Sekhniaidze, G.; Seliverstov, D. M.; Sellden, B.; Sellers, G.; Seman, M.; Semprini-Cesari, N.; Serfon, C.; Serin, L.; Seuster, R.; Severini, H.; Sevior, M. E.; Sfyrla, A.; Shabalina, E.; Shamim, M.; Shan, L. Y.; Shank, J. T.; Shao, Q. T.; Shapiro, M.; Shatalov, P. B.; Shaver, L.; Shaw, C.; Shaw, K.; Sherman, D.; Sherwood, P.; Shibata, A.; Shimizu, S.; Shimojima, M.; Shin, T.; Shmeleva, A.; Shochet, M. J.; Short, D.; Shupe, M. A.; Sicho, P.; Sidoti, A.; Siebel, A.; Siegert, F.; Siegrist, J.; Sijacki, Dj.; Silbert, O.; Silva, J.; Silver, Y.; Silverstein, D.; Silverstein, S. B.; Simak, V.; Simic, Lj.; Simion, S.; Simmons, B.; Simonyan, M.; Sinervo, P.; Sinev, N. B.; Sipica, V.; Siragusa, G.; Sisakyan, A. 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M.; Swedish, S.; Sykora, I.; Sykora, T.; Szeless, B.; Sánchez, J.; Ta, D.; Tackmann, K.; Taffard, A.; Tafirout, R.; Taga, A.; Taiblum, N.; Takahashi, Y.; Takai, H.; Takashima, R.; Takeda, H.; Takeshita, T.; Talby, M.; Talyshev, A.; Tamsett, M. C.; Tanaka, J.; Tanaka, R.; Tanaka, S.; Tanaka, S.; Tanaka, Y.; Tani, K.; Tannoury, N.; Tappern, G. P.; Tapprogge, S.; Tardif, D.; Tarem, S.; Tarrade, F.; Tartarelli, G. F.; Tas, P.; Tasevsky, M.; Tassi, E.; Tatarkhanov, M.; Taylor, C.; Taylor, F. E.; Taylor, G.; Taylor, G. N.; Taylor, W.; Teixeira Dias Castanheira, M.; Teixeira-Dias, P.; Temming, K. K.; Ten Kate, H.; Teng, P. K.; Tennenbaum-Katan, Y. D.; Terada, S.; Terashi, K.; Terron, J.; Terwort, M.; Testa, M.; Teuscher, R. J.; Tevlin, C. M.; Thadome, J.; Therhaag, J.; Theveneaux-Pelzer, T.; Thioye, M.; Thoma, S.; Thomas, J. P.; Thompson, E. N.; Thompson, P. D.; Thompson, P. D.; Thompson, A. S.; Thomson, E.; Thomson, M.; Thun, R. P.; Tic, T.; Tikhomirov, V. O.; Tikhonov, Y. A.; Timmermans, C. J. W. P.; Tipton, P.; Tique Aires Viegas, F. J.; Tisserant, S.; Tobias, J.; Toczek, B.; Todorov, T.; Todorova-Nova, S.; Toggerson, B.; Tojo, J.; Tokár, S.; Tokunaga, K.; Tokushuku, K.; Tollefson, K.; Tomoto, M.; Tompkins, L.; Toms, K.; Tonazzo, A.; Tong, G.; Tonoyan, A.; Topfel, C.; Topilin, N. D.; Torchiani, I.; Torrence, E.; Torró Pastor, E.; Toth, J.; Touchard, F.; Tovey, D. R.; Traynor, D.; Trefzger, T.; Treis, J.; Tremblet, L.; Tricoli, A.; Trigger, I. M.; Trincaz-Duvoid, S.; Trinh, T. N.; Tripiana, M. F.; Triplett, N.; Trischuk, W.; Trivedi, A.; Trocmé, B.; Troncon, C.; Trottier-McDonald, M.; Trzupek, A.; Tsarouchas, C.; Tseng, J. C.-L.; Tsiakiris, M.; Tsiareshka, P. V.; Tsionou, D.; Tsipolitis, G.; Tsiskaridze, V.; Tskhadadze, E. G.; Tsukerman, I. I.; Tsulaia, V.; Tsung, J.-W.; Tsuno, S.; Tsybychev, D.; Tua, A.; Tuggle, J. M.; Turala, M.; Turecek, D.; Turk Cakir, I.; Turlay, E.; Tuts, P. M.; Tykhonov, A.; Tylmad, M.; Tyndel, M.; Typaldos, D.; Tyrvainen, H.; Tzanakos, G.; Uchida, K.; Ueda, I.; Ueno, R.; Ugland, M.; Uhlenbrock, M.; Uhrmacher, M.; Ukegawa, F.; Unal, G.; Underwood, D. G.; Undrus, A.; Unel, G.; Unno, Y.; Urbaniec, D.; Urkovsky, E.; Urquijo, P.; Urrejola, P.; Usai, G.; Uslenghi, M.; Vacavant, L.; Vacek, V.; Vachon, B.; Vahsen, S.; Valderanis, C.; Valenta, J.; Valente, P.; Valentinetti, S.; Valkar, S.; Valladolid Gallego, E.; Vallecorsa, S.; Valls Ferrer, J. A.; van der Graaf, H.; van der Kraaij, E.; van der Poel, E.; van der Ster, D.; van Eijk, B.; van Eldik, N.; van Gemmeren, P.; van Kesteren, Z.; van Vulpen, I.; Vandelli, W.; Vandoni, G.; Vaniachine, A.; Vankov, P.; Vannucci, F.; Varela Rodriguez, F.; Vari, R.; Varnes, E. W.; Varouchas, D.; Vartapetian, A.; Varvell, K. E.; Vassilakopoulos, V. I.; Vazeille, F.; Vegni, G.; Veillet, J. J.; Vellidis, C.; Veloso, F.; Veness, R.; Veneziano, S.; Ventura, A.; Ventura, D.; Ventura, S.; Venturi, M.; Venturi, N.; Vercesi, V.; Verducci, M.; Verkerke, W.; Vermeulen, J. C.; Vertogardov, L.; Vetterli, M. C.; Vichou, I.; Vickey, T.; Viehhauser, G. H. A.; Viel, S.; Villa, M.; Villaplana Perez, M.; Vilucchi, E.; Vincter, M. G.; Vinek, E.; Vinogradov, V. B.; Virchaux, M.; Viret, S.; Virzi, J.; Vitale, A.; Vitells, O.; Vivarelli, I.; Vives Vaque, F.; Vlachos, S.; Vlasak, M.; Vlasov, N.; Vogel, A.; Vokac, P.; Volpi, M.; Volpini, G.; von der Schmitt, H.; von Loeben, J.; von Radziewski, H.; von Toerne, E.; Vorobel, V.; Vorobiev, A. P.; Vorwerk, V.; Vos, M.; Voss, R.; Voss, T. T.; Vossebeld, J. H.; Vovenko, A. S.; Vranjes, N.; Vranjes Milosavljevic, M.; Vrba, V.; Vreeswijk, M.; Vu Anh, T.; Vuillermet, R.; Vukotic, I.; Wagner, W.; Wagner, P.; Wahlen, H.; Wahrmund, S.; Wakabayashi, J.; Walbersloh, J.; Walch, S.; Walder, J.; Walker, R.; Walkowiak, W.; Wall, R.; Waller, P.; Wang, C.; Wang, H.; Wang, J.; Wang, J. C.; Wang, S. M.; Warburton, A.; Ward, C. P.; Warsinsky, M.; Wastie, R.; Watkins, P. M.; Watson, A. T.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, A. T.; Waugh, B. M.; Weber, J.; Weber, M.; Weber, M. S.; Weber, P.; Weidberg, A. R.; Weingarten, J.; Weiser, C.; Wellenstein, H.; Wells, P. S.; Wen, M.; Wenaus, T.; Wendler, S.; Weng, Z.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Werth, M.; Wessels, M.; Whalen, K.; Wheeler-Ellis, S. J.; Whitaker, S. P.; White, A.; White, M. J.; Whitehead, S. R.; Whiteson, D.; Whittington, D.; Wicek, F.; Wicke, D.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik, L. A. M.; Wildauer, A.; Wildt, M. A.; Wilhelm, I.; Wilkens, H. G.; Will, J. Z.; Williams, E.; Williams, H. H.; Willis, W.; Willocq, S.; Wilson, J. A.; Wilson, M. G.; Wilson, A.; Wingerter-Seez, I.; Winkelmann, S.; Winklmeier, F.; Wittgen, M.; Wolter, M. W.; Wolters, H.; Wooden, G.; Wosiek, B. K.; Wotschack, J.; Woudstra, M. J.; Wraight, K.; Wright, C.; Wrona, B.; Wu, S. L.; Wu, X.; Wulf, E.; Wunstorf, R.; Wynne, B. M.; Xaplanteris, L.; Xella, S.; Xie, S.; Xie, Y.; Xu, C.; Xu, D.; Xu, G.; Yabsley, B.; Yamada, M.; Yamamoto, A.; Yamamoto, K.; Yamamoto, S.; Yamamura, T.; Yamaoka, J.; Yamazaki, T.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, S.; Yang, U. K.; Yang, Y.; Yang, Y.; Yang, Z.; Yanush, S.; Yao, W.-M.; Yao, Y.; Yasu, Y.; Ye, J.; Ye, S.; Yilmaz, M.; Yoosoofmiya, R.; Yorita, K.; Yoshida, R.; Young, C.; Youssef, S.; Yu, D.; Yu, J.; Yu, J.; Yuan, L.; Yurkewicz, A.; Zaets, V. G.; Zaidan, R.; Zaitsev, A. M.; Zajacova, Z.; Zalite, Yo. K.; Zanello, L.; Zarzhitsky, P.; Zaytsev, A.; Zdrazil, M.; Zeitnitz, C.; Zeller, M.; Zema, P. F.; Zemla, A.; Zendler, C.; Zenin, A. V.; Zenin, O.; Ženiš, T.; Zenonos, Z.; Zenz, S.; Zerwas, D.; Zevi Della Porta, G.; Zhan, Z.; Zhang, H.; Zhang, J.; Zhang, X.; Zhang, Z.; Zhao, L.; Zhao, T.; Zhao, Z.; Zhemchugov, A.; Zheng, S.; Zhong, J.; Zhou, B.; Zhou, N.; Zhou, Y.; Zhu, C. G.; Zhu, H.; Zhu, Y.; Zhuang, X.; Zhuravlov, V.; Zieminska, D.; Zilka, B.; Zimmermann, R.; Zimmermann, S.; Zimmermann, S.; Ziolkowski, M.; Zitoun, R.; Živković, L.; Zmouchko, V. V.; Zobernig, G.; Zoccoli, A.; Zolnierowski, Y.; Zsenei, A.; Zur Nedden, M.; Zutshi, V.; Zwalinski, L.
2011-06-01
Measurements of charged particle distributions, sensitive to the underlying event, have been performed with the ATLAS detector at the LHC. The measurements are based on data collected using a minimum-bias trigger to select proton-proton collisions at center-of-mass energies of 900 GeV and 7 TeV. The “underlying event” is defined as those aspects of a hadronic interaction attributed not to the hard scattering process, but rather to the accompanying interactions of the rest of the proton. Three regions are defined in azimuthal angle with respect to the highest transverse momentum charged particle in the event, such that the region transverse to the dominant momentum-flow is most sensitive to the underlying event. In each of these regions, distributions of the charged particle multiplicity, transverse momentum density, and average pT are measured. The data show generally higher underlying event activity than that predicted by Monte Carlo models tuned to pre-LHC data.
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Khachatryan, V.
2015-09-21
A measurement of the underlying event (UE) activity in proton-proton collisions is performed using events with charged-particle jets produced in the central pseudorapidity region (|η jet| < 2) and with transverse momentum 1 ≤ p T jet < 100 GeV. The analysis uses a data sample collected at a centre-of-mass energy of 2.76 TeV with the CMS experiment at the LHC. The UE activity is measured as a function of p T jet in terms of the average multiplicity and scalar sum of transverse momenta (p T) of charged particles, with |η| < 2 and p T >more » 0.5 GeV, in the azimuthal region transverse to the highest p T jet direction. By further dividing the transverse region into two regions of smaller and larger activity, various components of the UE activity are separated. As a result, the measurements are compared to previous results at 0.9 and 7 TeV, and to predictions of several Monte Carlo event generators, providing constraints on the modelling of the UE dynamics« less
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Neural Dynamics Underlying Event-Related Potentials
NASA Technical Reports Server (NTRS)
Shah, Ankoor S.; Bressler, Steven L.; Knuth, Kevin H.; Ding, Ming-Zhou; Mehta, Ashesh D.; Ulbert, Istvan; Schroeder, Charles E.
2003-01-01
There are two opposing hypotheses about the brain mechanisms underlying sensory event-related potentials (ERPs). One holds that sensory ERPs are generated by phase resetting of ongoing electroencephalographic (EEG) activity, and the other that they result from signal averaging of stimulus-evoked neural responses. We tested several contrasting predictions of these hypotheses by direct intracortical analysis of neural activity in monkeys. Our findings clearly demonstrate evoked response contributions to the sensory ERP in the monkey, and they suggest the likelihood that a mixed (Evoked/Phase Resetting) model may account for the generation of scalp ERPs in humans.
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Metin, Baris; Wiersema, Jan R; Verguts, Tom; Gasthuys, Roos; van Der Meere, Jacob J; Roeyers, Herbert; Sonuga-Barke, Edmund
2016-01-01
According to the state regulation deficit (SRD) account, ADHD is associated with a problem using effort to maintain an optimal activation state under demanding task settings such as very fast or very slow event rates. This leads to a prediction of disrupted performance at event rate extremes reflected in higher Gaussian response variability that is a putative marker of activation during motor preparation. In the current study, we tested this hypothesis using ex-Gaussian modeling, which distinguishes Gaussian from non-Gaussian variability. Twenty-five children with ADHD and 29 typically developing controls performed a simple Go/No-Go task under four different event-rate conditions. There was an accentuated quadratic relationship between event rate and Gaussian variability in the ADHD group compared to the controls. The children with ADHD had greater Gaussian variability at very fast and very slow event rates but not at moderate event rates. The results provide evidence for the SRD account of ADHD. However, given that this effect did not explain all group differences (some of which were independent of event rate) other cognitive and/or motivational processes are also likely implicated in ADHD performance deficits.
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Azim, Riyasat; Li, Fangxing; Xue, Yaosuo; ...
2017-07-14
Distributed generations (DGs) for grid-connected applications require an accurate and reliable islanding detection methodology (IDM) for secure system operation. This paper presents an IDM for grid-connected inverter-based DGs. The proposed method is a combination of passive and active islanding detection techniques for aggregation of their advantages and elimination/minimisation of the drawbacks. In the proposed IDM, the passive method utilises critical system attributes extracted from local voltage measurements at target DG locations as well as employs decision tree-based classifiers for characterisation and detection of islanding events. The active method is based on Sandia frequency shift technique and is initiated only whenmore » the passive method is unable to differentiate islanding events from other system events. Thus, the power quality degradation introduced into the system by active islanding detection techniques can be minimised. Furthermore, a combination of active and passive techniques allows detection of islanding events under low power mismatch scenarios eliminating the disadvantage associated with the use of passive techniques alone. Finally, detailed case study results demonstrate the effectiveness of the proposed method in detection of islanding events under various power mismatch scenarios, load quality factors and in the presence of single or multiple grid-connected inverter-based DG units.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Azim, Riyasat; Li, Fangxing; Xue, Yaosuo
Distributed generations (DGs) for grid-connected applications require an accurate and reliable islanding detection methodology (IDM) for secure system operation. This paper presents an IDM for grid-connected inverter-based DGs. The proposed method is a combination of passive and active islanding detection techniques for aggregation of their advantages and elimination/minimisation of the drawbacks. In the proposed IDM, the passive method utilises critical system attributes extracted from local voltage measurements at target DG locations as well as employs decision tree-based classifiers for characterisation and detection of islanding events. The active method is based on Sandia frequency shift technique and is initiated only whenmore » the passive method is unable to differentiate islanding events from other system events. Thus, the power quality degradation introduced into the system by active islanding detection techniques can be minimised. Furthermore, a combination of active and passive techniques allows detection of islanding events under low power mismatch scenarios eliminating the disadvantage associated with the use of passive techniques alone. Finally, detailed case study results demonstrate the effectiveness of the proposed method in detection of islanding events under various power mismatch scenarios, load quality factors and in the presence of single or multiple grid-connected inverter-based DG units.« less
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Well-being and Anticipation for Future Positive Events: Evidences from an fMRI Study.
Luo, Yangmei; Chen, Xuhai; Qi, Senqing; You, Xuqun; Huang, Xiting
2017-01-01
Anticipation for future confers great benefits to human well-being and mental health. However, previous work focus on how people's well-being correlate with brain activities during perception of emotional stimuli, rather than anticipation for the future events. Here, the current study investigated how well-being relates to neural circuitry underlying the anticipating process of future desired events. Using event-related functional magnetic resonance imaging, 40 participants were scanned while they were performing an emotion anticipation task, in which they were instructed to anticipate the positive or neutral events. The results showed that bilateral medial prefrontal cortex (MPFC) were activated during anticipation for positive events relative to neutral events, and the enhanced brain activation in MPFC was associated with higher level of well-being. The findings suggest a neural mechanism by which the anticipation process to future desired events correlates to human well-being, which provide a future-oriented view on the neural sources of well-being.
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Well-being and Anticipation for Future Positive Events: Evidences from an fMRI Study
Luo, Yangmei; Chen, Xuhai; Qi, Senqing; You, Xuqun; Huang, Xiting
2018-01-01
Anticipation for future confers great benefits to human well-being and mental health. However, previous work focus on how people’s well-being correlate with brain activities during perception of emotional stimuli, rather than anticipation for the future events. Here, the current study investigated how well-being relates to neural circuitry underlying the anticipating process of future desired events. Using event-related functional magnetic resonance imaging, 40 participants were scanned while they were performing an emotion anticipation task, in which they were instructed to anticipate the positive or neutral events. The results showed that bilateral medial prefrontal cortex (MPFC) were activated during anticipation for positive events relative to neutral events, and the enhanced brain activation in MPFC was associated with higher level of well-being. The findings suggest a neural mechanism by which the anticipation process to future desired events correlates to human well-being, which provide a future-oriented view on the neural sources of well-being. PMID:29375415
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Wang, Chong; Long, Wenying; Peng, Chao; Hu, Lin; Zhang, Qiong; Wu, Ailing; Zhang, Xiaoqing; Duan, Xiaotao; Wong, Catherine C L; Tanaka, Yuetsu; Xia, Zongping
2016-04-01
The HTLV-1 oncoprotein Tax plays a key role in CD4+ T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in understanding HTLV-1-mediated transformation. Current studies have suggested multiple but controversial mechanisms regarding Tax-induced IKK activation mainly due to blending of primary Tax-induced IKK activation events and secondary IKK activation events induced by cytokines secreted by the primary Tax-induced IKK-NF-κB activation events. We reconstituted Tax-stimulated IKK activation in a cell-free system to dissect the essential cellular components for primary IKK activation by Tax and studied the underlying biochemical mechanism. We found that Tax is a putative E3 ubiquitin ligase, which, together with UbcH2, UhcH5c, or UbcH7, catalyzes the assembly of free mixed-linkage polyubiquitin chains. These free mixed-linkage polyubiquitin chains are then responsible for direct IKK activation by binding to the NEMO subunit of IKK. Our studies revealed the biochemical function of Tax in the process of IKK activation, which utilizes the minimal cellular ubiquitination components for NF-κB activation.
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Wang, Chong; Long, Wenying; Peng, Chao; Hu, Lin; Zhang, Qiong; Wu, Ailing; Zhang, Xiaoqing; Duan, Xiaotao; Wong, Catherine C. L.; Tanaka, Yuetsu; Xia, Zongping
2016-01-01
The HTLV-1 oncoprotein Tax plays a key role in CD4+ T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in understanding HTLV-1-mediated transformation. Current studies have suggested multiple but controversial mechanisms regarding Tax-induced IKK activation mainly due to blending of primary Tax-induced IKK activation events and secondary IKK activation events induced by cytokines secreted by the primary Tax-induced IKK-NF-κB activation events. We reconstituted Tax-stimulated IKK activation in a cell-free system to dissect the essential cellular components for primary IKK activation by Tax and studied the underlying biochemical mechanism. We found that Tax is a putative E3 ubiquitin ligase, which, together with UbcH2, UhcH5c, or UbcH7, catalyzes the assembly of free mixed-linkage polyubiquitin chains. These free mixed-linkage polyubiquitin chains are then responsible for direct IKK activation by binding to the NEMO subunit of IKK. Our studies revealed the biochemical function of Tax in the process of IKK activation, which utilizes the minimal cellular ubiquitination components for NF-κB activation. PMID:27082114
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Celebrating the International Year of Light in Michigan
NASA Astrophysics Data System (ADS)
Sala, Anca L.; Dreyer, Elizabeth F. C.; Aku-Leh, Cynthia; Jones, Timothy; Nees, John A.; Smith, Arlene
2016-09-01
The 2015 International Year of Light created a wonderful opportunity to bring light and optics events and activities to people of all ages and occupations in Michigan. A large spectrum of events took place; from events held in schools, colleges, and universities targeting various groups of students, to events associated with festivals attended by large crowds. The latter included the Ann Arbor Summer Festival held in June and the Flint Back-to-the-Bricks Festival in August. All events included interactive activities where participants learned hands-on about optics and photonics phenomena and applications. Original demonstrations and kits were developed by the Ann Arbor OSA Local Section and the Optics Society at the University of Michigan, the joint OSA/SPIE student chapter, for use during the events. The activities were funded through the student chapter's SPIE grant for IYL outreach events and corporate sponsorships. Under the name Michigan Light Project, these groups along with local technology enthusiasts and science clubs delivered several events across Michigan. Other events took place throughout the year in Mid-Michigan through the efforts of faculty and students in the Photonics and Laser Technology program at Baker College of Flint. The outreach events targeted students in K-12. Teachers, counselors, and parents also learned about the importance of optics and photonics in society. The activities developed will continue this year and in the future. The paper will provide details on the completed events and activities along with tips for implementing similar activities and outreach partnerships in other areas.
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Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
Buetfering, Christina; Groblewski, Peter A.; Manavi, Sahar; Miles, Jesse; White, Casey; Griffin, Fiona; Roll, Kate; Cross, Sissy; Nguyen, Thuyanh V.; Larsen, Rachael; Daigle, Tanya; Thompson, Carol L.; Olsen, Shawn; Hausser, Michael
2017-01-01
Abstract Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors. These epileptiform events have been observed particularly, but not exclusively, in mice with Emx1-Cre and Ai93 transgenes, of either sex, across multiple laboratories. The events occur at >0.1 Hz, are very large in amplitude (>1.0 mV local field potentials, >10% df/f widefield imaging signals), and typically cover large regions of cortex. Many properties of neuronal responses and behavior seem normal despite these events, although rare subjects exhibit overt generalized seizures. The underlying mechanisms of this phenomenon remain unclear, but we speculate about possible causes on the basis of diverse observations. We encourage researchers to be aware of these activity patterns while interpreting neuronal recordings from affected mouse lines and when considering which lines to study. PMID:28932809
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``Mirando al Cielo'', Organization of Public Events for Sky Observations
NASA Astrophysics Data System (ADS)
Parrao, L.
2011-10-01
The events called ``Mirando al cielo'' encompass academic, cultural and economic activities with the purpose of promoting the knowledge and furthering the economy of the place where they are held. The academic activities are carried out by students and teachers of the region, and have been organized by UNAM. The cultural and commercial activities are selected among those typical of each place and carried out under the direction of local authorities, with the participation of their inhabitants.
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Ciclovía Participation and Impacts in San Diego, CA: The First CicloSDias
Engelberg, Jessa K.; Carlson, Jordan A.; Black, Michelle L.; Ryan, Sherry; Sallis, James F.
2014-01-01
Objective Ciclovía or Open Streets initiatives support physical activity through cycling/rolling, and walking/running. We evaluated San Diego’s first Open Streets event, CicloSDias, to document attendance, reach and marketing, and effects on social cohesion, businesses, and physical activity. Methods The comprehensive evaluation consisted of a city-wide survey 1 week before and after the event (n=805), counts of event attendees, and surveys of event attendees (n=713) and businesses (n=26). Results An estimated 8,311 people attended the event. Attendees had an average of 144 minutes (SD=85) of physical activity, 97% met the 30 minute/day guideline, and 39% met the 150 minute/week guideline during the event. 27% of attendees would have been inactive without the event. Awareness of the event was 10% before and 26% after the event. When comparing event attendees to San Diego residents, Latinos and non-white race/ethnicities were under-represented. Restaurants/pubs, services, and most retail stores excluding liquor stores and food markets reported positive or neutral impacts on business. Conclusion Open Street initiatives are promising ways to promote physical activity and are desired by the community. Positive effects were observed for physical activity, social cohesion, and businesses, though reach should be expanded to include more underserved community members. Evaluating Open Streets is important for sustaining and improving these efforts. PMID:25459488
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Tang, Tiantian; Lang, Xueting; Xu, Congfei; Wang, Xiaqiong; Gong, Tao; Yang, Yanqing; Cui, Jun; Bai, Li; Wang, Jun; Jiang, Wei; Zhou, Rongbin
2017-08-04
The NLRP3 inflammasome can sense different pathogens or danger signals, and has been reported to be involved in the development of many human diseases. Potassium efflux and mitochondrial damage are both reported to mediate NLRP3 inflammasome activation, but the underlying, orchestrating signaling events are still unclear. Here we show that chloride intracellular channels (CLIC) act downstream of the potassium efflux-mitochondrial reactive oxygen species (ROS) axis to promote NLRP3 inflammasome activation. NLRP3 agonists induce potassium efflux, which causes mitochondrial damage and ROS production. Mitochondrial ROS then induces the translocation of CLICs to the plasma membrane for the induction of chloride efflux to promote NEK7-NLRP3 interaction, inflammasome assembly, caspase-1 activation, and IL-1β secretion. Thus, our results identify CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. Here the authors show that chloride intracellular channels (CLIC) interface between mitochondria stress and inflammasome activation to modulate inflammatory responses.
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Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; ...
2012-09-20
A measurement of the underlying event (UE) activity in proton-proton collisions at a center-of-mass energy of 7 TeV is performed using Drell--Yan events in a data sample corresponding to an integrated luminosity of 2.2 inverse femtobarns, collected by the CMS experiment at the LHC. The activity measured in the muonic final state (q q-bar to opposite-sign muons) is corrected to the particle level and compared with the predictions of various Monte Carlo generators and hadronization models. The dependence of the UE activity on the dimuon invariant mass is well described by PYTHIA and HERWIG++ tunes derived from the leading jet/trackmore » approach, illustrating the universality of the UE activity. The UE activity is observed to be independent of the dimuon invariant mass in the region above 40 GeV, while a slow increase is observed with increasing transverse momentum of the dimuon system. The dependence of the UE activity on the transverse momentum of the dimuon system is accurately described by MADGRAPH, which simulates multiple hard emissions.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.
A measurement of the underlying event (UE) activity in proton-proton collisions at a center-of-mass energy of 7 TeV is performed using Drell--Yan events in a data sample corresponding to an integrated luminosity of 2.2 inverse femtobarns, collected by the CMS experiment at the LHC. The activity measured in the muonic final state (q q-bar to opposite-sign muons) is corrected to the particle level and compared with the predictions of various Monte Carlo generators and hadronization models. The dependence of the UE activity on the dimuon invariant mass is well described by PYTHIA and HERWIG++ tunes derived from the leading jet/trackmore » approach, illustrating the universality of the UE activity. The UE activity is observed to be independent of the dimuon invariant mass in the region above 40 GeV, while a slow increase is observed with increasing transverse momentum of the dimuon system. The dependence of the UE activity on the transverse momentum of the dimuon system is accurately described by MADGRAPH, which simulates multiple hard emissions.« less
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Rule-Based Event Processing and Reaction Rules
NASA Astrophysics Data System (ADS)
Paschke, Adrian; Kozlenkov, Alexander
Reaction rules and event processing technologies play a key role in making business and IT / Internet infrastructures more agile and active. While event processing is concerned with detecting events from large event clouds or streams in almost real-time, reaction rules are concerned with the invocation of actions in response to events and actionable situations. They state the conditions under which actions must be taken. In the last decades various reaction rule and event processing approaches have been developed, which for the most part have been advanced separately. In this paper we survey reaction rule approaches and rule-based event processing systems and languages.
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Ultrafast table-top dynamic radiography of spontaneous or stimulated events
Smilowitz, Laura; Henson, Bryan
2018-01-16
Disclosed herein are representative embodiments of methods, apparatus, and systems for performing radiography. For example, certain embodiments concern X-ray radiography of spontaneous events. Particular embodiments of the disclosed technology provide continuous high-speed x-ray imaging of spontaneous dynamic events, such as explosions, reaction-front propagation, and even material failure. Further, in certain embodiments, x-ray activation and data collection activation are triggered by the object itself that is under observation (e.g., triggered by a change of state detected by one or more sensors monitoring the object itself).
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.
The underlying event activity in proton-proton collisions at forward pseudo-rapidity (-6.6 < η < -5.2) is studied with the CMS detector at the LHC, using a novel observable: the ratio of the forward energy density, dE/dη, for events with a charged-particle jet produced at central pseudorapidity (|η jet| < 2) to the forward energy density for inclusive events. This forward energy density ratio is measured as a function of the central jet transverse momentum, p (T), at three different pp centre-of-mass energies (more » $$\\sqrt{s}$$ = 0.9, 2.76, and 7 TeV). In addition, the evolution of the forward energy density is studied in inclusive events and in events with a central jet. The results are compared to those of Monte Carlo event generators for pp collisions and are discussed in terms of the underlying event. Whereas the dependence of the forward energy density ratio on jet p T at each separately can be well reproduced by some models, all models fail to simultaneously describe the increase of the forward energy density with in both inclusive events and in events with a central jet.« less
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Yokotsuka, M; Aoyama, M; Kubota, K
2000-07-01
The Medical Dictionary for Regulatory Activities Terminology (MedDRA) version 2.1 (V2.1) was released in March 1999 accompanied by the MedDRA/J V2.1J specifically for Japanese users. In prescription-event monitoring in Japan (J-PEM), we have employed the MedDRA/J for data entry, signal generation and event listing. In J-PEM, the lowest level terms (LLTs) in the MedDRA/J are used in data entry because the richness of LLTs is judged to be advantageous. A signal is generated normally at the preferred term (PT) level, but it has been found that various reporters describe the same event using descriptions that are potentially encoded by LLTs under different PTs. In addition, some PTs are considered too specific to generate the proper signal. In the system used in J-PEM, when an LLT is selected as a candidate to encode an event, another LLT under a different PT, if any, is displayed on the computer screen so that it may be coded instead of, or in addition to, the candidate LLT. The five-level structure of the MedDRA is used when listing events but some modification is required to generate a functional event list.
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NASA Astrophysics Data System (ADS)
Leckebusch, G. C.; Ulbrich, U.
2003-04-01
More than any changes of the climate system mean state conditions, the development of extreme events may influence social, economic and legal aspects of our society. This linkage results from the impact of extreme climate events (natural hazards) on environmental systems which again are directly linked to human activities. Prominent examples from the recent past are the record breaking rainfall amounts of August 2002 in central Europe which produced widespread floodings or the wind storm Lothar of December 1999. Within the MICE (Modelling the Impact of Climate Extremes) project framework an assessment of the impact of changes in extremes will be done. The investigation is carried out for several different impact categories as agriculture, energy use and property damage. Focus is laid on the diagnostics of GCM and RCM simulations under different climate change scenarios. In this study we concentrate on extreme windstorms and their relationship to cyclone activity in the global HADCM3 as well as in the regional HADRM3 model under two climate change scenarios (SRESA2a, B2a). In order to identify cyclones we used an objective algorithm from Murry and Simmonds which was widely tested under several different conditions. A slight increase in the occurrence of systems is identified above northern parts of central Europe for both scenarios. For more severe systems (core pressure < 990 hPa) we find an increase for western Europe. Strong wind events can be defined via different percentile values of the windspeed (e.g. above the 95 percentile). By this means the relationship between strong wind events and cyclones is also investigated. For several regions (e.g. Germany, France, Spain) a shift to more deep cyclones connected with an increasing number of strong wind events is found.
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Rising Tides or Rising Stars?: Dynamics of Shared Attention on Twitter during Media Events
Lin, Yu-Ru; Keegan, Brian; Margolin, Drew; Lazer, David
2014-01-01
“Media events” generate conditions of shared attention as many users simultaneously tune in with the dual screens of broadcast and social media to view and participate. We examine how collective patterns of user behavior under conditions of shared attention are distinct from other “bursts” of activity like breaking news events. Using 290 million tweets from a panel of 193,532 politically active Twitter users, we compare features of their behavior during eight major events during the 2012 U.S. presidential election to examine how patterns of social media use change during these media events compared to “typical” time and whether these changes are attributable to shifts in the behavior of the population as a whole or shifts from particular segments such as elites. Compared to baseline time periods, our findings reveal that media events not only generate large volumes of tweets, but they are also associated with (1) substantial declines in interpersonal communication, (2) more highly concentrated attention by replying to and retweeting particular users, and (3) elite users predominantly benefiting from this attention. These findings empirically demonstrate how bursts of activity on Twitter during media events significantly alter underlying social processes of interpersonal communication and social interaction. Because the behavior of large populations within socio-technical systems can change so dramatically, our findings suggest the need for further research about how social media responses to media events can be used to support collective sensemaking, to promote informed deliberation, and to remain resilient in the face of misinformation. PMID:24854030
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78 FR 8159 - Agency Information Collection Activities: Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-05
... Performance and Results Act (GPRA) Customer Satisfaction instruments (OMB No. 0930-0197). CSAT is not seeking... under CSAT Government Performance and Results Act (GPRA) Customer Satisfaction form (OMB 0930- 0197...: Technical assistance events, meetings, and trainings. An ATTC technical assistance event is defined as a...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... of the property under restricted conditions and termination of the license. Design bases means that... events include— (1) Estimates of severe natural events to be used for deriving design bases that will be... to be used for deriving design bases that will be based on analysis of human activity in the region...
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Using Active Learning to Identify Health Information Technology Related Patient Safety Events.
Fong, Allan; Howe, Jessica L; Adams, Katharine T; Ratwani, Raj M
2017-01-18
The widespread adoption of health information technology (HIT) has led to new patient safety hazards that are often difficult to identify. Patient safety event reports, which are self-reported descriptions of safety hazards, provide one view of potential HIT-related safety events. However, identifying HIT-related reports can be challenging as they are often categorized under other more predominate clinical categories. This challenge of identifying HIT-related reports is exacerbated by the increasing number and complexity of reports which pose challenges to human annotators that must manually review reports. In this paper, we apply active learning techniques to support classification of patient safety event reports as HIT-related. We evaluated different strategies and demonstrated a 30% increase in average precision of a confirmatory sampling strategy over a baseline no active learning approach after 10 learning iterations.
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Voluntary control over prestimulus activity related to encoding
Gruber, Matthias J.; Otten, Leun J.
2010-01-01
A new development in our understanding of human long-term memory is that effective memory formation relies on neural activity just before an event. It is unknown whether such prestimulus activity is under voluntary control or a reflection of random fluctuations over time. In the present study, we addressed two issues: (i) whether prestimulus activity is influenced by an individual's motivation to encode, and (ii) at what point in time encoding-related activity emerges. Electrical brain activity was recorded while healthy male and female adults memorized series of words. Each word was preceded by a cue, which indicated the monetary reward that would be received if the following word was later remembered. Memory was tested after a short delay with a five-way recognition task to separate different sources of recognition. Electrical activity elicited by the reward cue predicted later memory of a word. Crucially, however, this was only observed when the incentive to memorize a word was high. Encoding-related activity preceded high reward words that were later recollected. This activity started shortly after cue onset and persisted until word onset. Prestimulus activity thus not only signals cue-related processing, but also an ensuing preparatory state. In contrast, reward-related activity was limited to the time period immediately following the reward cue. These findings indicate that engaging neural activity that benefits the encoding of an upcoming event is under voluntary control, reflecting a strategic preparatory state in anticipation of processing an event. PMID:20660262
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NASA Astrophysics Data System (ADS)
Hanson, P. R.; Arbogast, A. F.; Johnson, W. C.; Joeckel, R. M.; Young, A. R.
2010-01-01
Optical and radiocarbon dating indicates that alluvium underlying dunes near Abilene was deposited at or before ˜45 ka, and that the overlying dunes were active at ˜1.1-0.5 ka. Geochemical data indicate that the Abilene dune sand is immature and was derived from the underlying Pleistocene alluvium, and not from Holocene age Smoky Hill River deposits. These findings suggest that dune activation was a response to increased aridity and local reduction in vegetation cover as opposed to changes in sediment availability from nearby rivers. The time interval of dune activation at Abilene overlaps Medieval Warm Period megadroughts, similar to the larger and more westerly dune fields on the Great Plains, including the Nebraska Sand Hills and the Great Bend Sand Prairie. The activation of smaller dune fields such as the Abilene dunes near the more humid eastern margin of the Great Plains shows the geographic extent and severity of paleodrought events. Unlike the Duncan dunes, another plains-marginal dune field, however, the Abilene dunes show no evidence for multiple drought events during the Holocene. This difference in dune activity, if it is not a result of sampling or preservation bias, indicates variations in the extent and severity of older drought events at the eastern margin of the Great Plains.
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Compound Event Barrier Coverage in Wireless Sensor Networks under Multi-Constraint Conditions.
Zhuang, Yaoming; Wu, Chengdong; Zhang, Yunzhou; Jia, Zixi
2016-12-24
It is important to monitor compound event by barrier coverage issues in wireless sensor networks (WSNs). Compound event barrier coverage (CEBC) is a novel coverage problem. Unlike traditional ones, the data of compound event barrier coverage comes from different types of sensors. It will be subject to multiple constraints under complex conditions in real-world applications. The main objective of this paper is to design an efficient algorithm for complex conditions that can combine the compound event confidence. Moreover, a multiplier method based on an active-set strategy (ASMP) is proposed to optimize the multiple constraints in compound event barrier coverage. The algorithm can calculate the coverage ratio efficiently and allocate the sensor resources reasonably in compound event barrier coverage. The proposed algorithm can simplify complex problems to reduce the computational load of the network and improve the network efficiency. The simulation results demonstrate that the proposed algorithm is more effective and efficient than existing methods, especially in the allocation of sensor resources.
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Compound Event Barrier Coverage in Wireless Sensor Networks under Multi-Constraint Conditions
Zhuang, Yaoming; Wu, Chengdong; Zhang, Yunzhou; Jia, Zixi
2016-01-01
It is important to monitor compound event by barrier coverage issues in wireless sensor networks (WSNs). Compound event barrier coverage (CEBC) is a novel coverage problem. Unlike traditional ones, the data of compound event barrier coverage comes from different types of sensors. It will be subject to multiple constraints under complex conditions in real-world applications. The main objective of this paper is to design an efficient algorithm for complex conditions that can combine the compound event confidence. Moreover, a multiplier method based on an active-set strategy (ASMP) is proposed to optimize the multiple constraints in compound event barrier coverage. The algorithm can calculate the coverage ratio efficiently and allocate the sensor resources reasonably in compound event barrier coverage. The proposed algorithm can simplify complex problems to reduce the computational load of the network and improve the network efficiency. The simulation results demonstrate that the proposed algorithm is more effective and efficient than existing methods, especially in the allocation of sensor resources. PMID:28029118
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Sequential parallel comparison design with binary and time-to-event outcomes.
Silverman, Rachel Kloss; Ivanova, Anastasia; Fine, Jason
2018-04-30
Sequential parallel comparison design (SPCD) has been proposed to increase the likelihood of success of clinical trials especially trials with possibly high placebo effect. Sequential parallel comparison design is conducted with 2 stages. Participants are randomized between active therapy and placebo in stage 1. Then, stage 1 placebo nonresponders are rerandomized between active therapy and placebo. Data from the 2 stages are pooled to yield a single P value. We consider SPCD with binary and with time-to-event outcomes. For time-to-event outcomes, response is defined as a favorable event prior to the end of follow-up for a given stage of SPCD. We show that for these cases, the usual test statistics from stages 1 and 2 are asymptotically normal and uncorrelated under the null hypothesis, leading to a straightforward combined testing procedure. In addition, we show that the estimators of the treatment effects from the 2 stages are asymptotically normal and uncorrelated under the null and alternative hypothesis, yielding confidence interval procedures with correct coverage. Simulations and real data analysis demonstrate the utility of the binary and time-to-event SPCD. Copyright © 2018 John Wiley & Sons, Ltd.
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[Unconscious Acoustical Stimuli Effects on Event-related Potentials in Humans].
Kopeikina, E A; Choroshich, V V; Aleksandrov, A Y; Ivanova, V Y
2015-01-01
Unconscious perception essentially affects human behavior. The main results in this area obtained in experiments with visual stimuli. However, the acoustical stimuli play not less important role in behavior. The main idea of this paper is the electroencephalographic investigation of unconscious acoustical stimulation effects on electro-physiological activity of the brain. For this purpose, the event-related potentials were acquired under unconscious stimulus priming paradigm. The one syllable, three letter length, Russian words and pseudo-words with single letter substitution were used as primes and targets. As a result, we find out that repetition and alternative priming similarly affects the event-related potential's component with 200 ms latency after target application in frontal parietal and temporal areas. Under alternative priming the direction of potential amplitude modification nearby 400 ms was altered for word and semi-word targets. Alternative priming reliably increase ERP's amplitude in 400 ms locality with pseudo-word targets and decrease it under word targets. Taking into account, that all participants were unable to distinguish the applied prime stimuli, we can assume that the event-related potential changes evoked by unconscious perception of acoustical stimuli. The ERP amplitude dynamics revealed in current investigation demonstrate the opportunity of subliminal acoustical stimuli to modulate the electrical activity evoked by verbal acoustical stimulation.
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20 CFR 404.325 - The termination month.
Code of Federal Regulations, 2011 CFR
2011-04-01
... activity level and continue to do so throughout the 36 months following completion of your trial work... third month following the earliest month you perform substantial gainful activity or are determined able to perform substantial gainful activity; however, in no event will the termination month under these...
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20 CFR 404.325 - The termination month.
Code of Federal Regulations, 2010 CFR
2010-04-01
... activity level and continue to do so throughout the 36 months following completion of your trial work... third month following the earliest month you perform substantial gainful activity or are determined able to perform substantial gainful activity; however, in no event will the termination month under these...
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Richter, Anja; Gruber, Oliver
2018-02-01
It is argued that the mesolimbic system has a more general function in processing all salient events, including and extending beyond rewards. Saliency was defined as an event that is unexpected due to its frequency of occurrence and elicits an attentional-behavioral switch. Using functional magnetic resonance imaging (fMRI), signals were measured in response to the modulation of salience of rewarding and nonrewarding events during a reward-based decision making task, the so called desire-reason dilemma paradigm (DRD). Replicating previous findings, both frequent and infrequent, and therefore salient, reward stimuli elicited reliable activation of the ventral tegmental area (VTA) and ventral striatum (vStr). When immediate reward desiring contradicted the superordinate task-goal, we found an increased activation of the VTA and vStr when the salient reward stimuli were presented compared to the nonsalient reward stimuli, indicating a boosting of activation in these brain regions. Furthermore, we found a significantly increased functional connectivity between the VTA and vStr, confirming the boosting of vStr activation via VTA input. Moreover, saliency per se without a reward association led to an increased activation of brain regions in the mesolimbic reward system as well as the orbitofrontal cortex (OFC), inferior frontal gyrus (IFG), and anterior cingulate cortex (ACC). Finally, findings uncovered multiple increased functional interactions between cortical saliency-processing brain areas and the VTA and vStr underlying detection and processing of salient events and adaptive decision making. © 2017 Wiley Periodicals, Inc.
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The Power of Nature. World's Largest Math Event 5.
ERIC Educational Resources Information Center
National Council of Teachers of Mathematics, Inc., Reston, VA.
The theme of the fifth annual World's Largest Math Event (WLME 5) is "The Power of Nature." This theme encourages students to explore natural forces that affect humankind, including phenomena such as hurricanes, earthquakes, and snowstorms, and the mathematics that underlies their study. The 15 activities for WLMES have been grouped into five…
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Kids and Chemistry: Large Event Guide.
ERIC Educational Resources Information Center
Tinnesand, Michael
This guide is intended to provide Kids and Chemistry (K&C) with a variety of age-appropriate, fun, and safe demonstrations. It features information on planning a large event and includes safety guidelines. Several activities are included under each major topic. Topics include: (1) Acids and Bases; (2) Unsigned; (3) Kool Tie-Dye; (4) Secret…
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Napadow, Vitaly; Lee, Jeungchan; Kim, Jieun; Cina, Stephen; Maeda, Yumi; Barbieri, Riccardo; Harris, Richard E.; Kettner, Norman; Park, Kyungmo
2013-01-01
Autonomic nervous system (ANS) response to acupuncture has been investigated by multiple studies; however, the brain circuitry underlying this response is not well understood. We applied event-related fMRI (er-fMRI) in conjunction with ANS recording (heart rate, HR; skin conductance response, SCR). Brief manual acupuncture stimuli were delivered at acupoints ST36 and SP9, while sham stimuli were delivered at control location, SH1. Acupuncture produced activation in S2, insula, and mid-cingulate cortex, and deactivation in default mode network (DMN) areas. On average, HR deceleration (HR–) and SCR were noted following both real and sham acupuncture, though magnitude of response was greater following real acupuncture and inter-subject magnitude of response correlated with evoked sensation intensity. Acupuncture events with strong SCR also produced greater anterior insula activation than without SCR. Moreover, acupuncture at SP9, which produced greater SCR, also produced stronger sharp pain sensation, and greater anterior insula activation. Conversely, acupuncture-induced HR– was associated with greater DMN deactivation. Between-event correlation demonstrated that this association was strongest for ST36, which also produced more robust HR–. In fact, DMN deactivation was significantly more pronounced across acupuncture stimuli producing HR–, versus those events characterized by acceleration (HR+). Thus, differential brain response underlying acupuncture stimuli may be related to differential autonomic outflows and may result from heterogeneity in evoked sensations. Our er-fMRI approach suggests that ANS response to acupuncture, consistent with previously characterized orienting and startle/defense responses, arises from activity within distinct subregions of the more general brain circuitry responding to acupuncture stimuli. PMID:22504841
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Forecasting Significant Societal Events Using The Embers Streaming Predictive Analytics System
Katz, Graham; Summers, Kristen; Ackermann, Chris; Zavorin, Ilya; Lim, Zunsik; Muthiah, Sathappan; Butler, Patrick; Self, Nathan; Zhao, Liang; Lu, Chang-Tien; Khandpur, Rupinder Paul; Fayed, Youssef; Ramakrishnan, Naren
2014-01-01
Abstract Developed under the Intelligence Advanced Research Project Activity Open Source Indicators program, Early Model Based Event Recognition using Surrogates (EMBERS) is a large-scale big data analytics system for forecasting significant societal events, such as civil unrest events on the basis of continuous, automated analysis of large volumes of publicly available data. It has been operational since November 2012 and delivers approximately 50 predictions each day for countries of Latin America. EMBERS is built on a streaming, scalable, loosely coupled, shared-nothing architecture using ZeroMQ as its messaging backbone and JSON as its wire data format. It is deployed on Amazon Web Services using an entirely automated deployment process. We describe the architecture of the system, some of the design tradeoffs encountered during development, and specifics of the machine learning models underlying EMBERS. We also present a detailed prospective evaluation of EMBERS in forecasting significant societal events in the past 2 years. PMID:25553271
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Probing collective effects in hadronisation with the extremes of the underlying event
NASA Astrophysics Data System (ADS)
Martin, T.; Skands, P.; Farrington, S.
2016-05-01
We define a new set of observables to probe the structure of the underlying event in hadron collisions. We use the conventional definition of the "transverse region" in jet events and, for a fixed window in jet p_perp , propose to measure several discriminating quantities as a function of the level of activity in the transverse region. The measurement of these observables in LHC data would reveal whether, e.g., the properties of "low-UE" events are compatible with equivalent measurements in e^+e^- collisions (jet universality), and whether the scaling behaviour towards "high-UE" events exhibits properties of non-trivial soft-QCD dynamics, such as colour reconnections or other collective phenomena. We illustrate at √{s} = 13 {TeV} that significant discriminatory power is obtained in comparisons between MC models with varying treatments of collective effects, including Pythia 8, epos, and Dipsy.
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Forecasting Significant Societal Events Using The Embers Streaming Predictive Analytics System.
Doyle, Andy; Katz, Graham; Summers, Kristen; Ackermann, Chris; Zavorin, Ilya; Lim, Zunsik; Muthiah, Sathappan; Butler, Patrick; Self, Nathan; Zhao, Liang; Lu, Chang-Tien; Khandpur, Rupinder Paul; Fayed, Youssef; Ramakrishnan, Naren
2014-12-01
Developed under the Intelligence Advanced Research Project Activity Open Source Indicators program, Early Model Based Event Recognition using Surrogates (EMBERS) is a large-scale big data analytics system for forecasting significant societal events, such as civil unrest events on the basis of continuous, automated analysis of large volumes of publicly available data. It has been operational since November 2012 and delivers approximately 50 predictions each day for countries of Latin America. EMBERS is built on a streaming, scalable, loosely coupled, shared-nothing architecture using ZeroMQ as its messaging backbone and JSON as its wire data format. It is deployed on Amazon Web Services using an entirely automated deployment process. We describe the architecture of the system, some of the design tradeoffs encountered during development, and specifics of the machine learning models underlying EMBERS. We also present a detailed prospective evaluation of EMBERS in forecasting significant societal events in the past 2 years.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-19
... involve underwater explosive detonation, projectile firing, and sonar testing. Summary of Activity Under..., most of the mid-frequency active sonar (MFAS) and high-frequency active sonar (HFAS) testing events... (Number Authorized vs. Conducted). Number Number Sonar system authorized conducted (hrs) (hrs) AN/SQS-53...
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Cultured Neuronal Networks Express Complex Patterns of Activity and Morphological Memory
NASA Astrophysics Data System (ADS)
Raichman, Nadav; Rubinsky, Liel; Shein, Mark; Baruchi, Itay; Volman, Vladislav; Ben-Jacob, Eshel
The following sections are included: * Cultured Neuronal Networks * Recording the Network Activity * Network Engineering * The Formation of Synchronized Bursting Events * The Characterization of the SBEs * Highly-Active Neurons * Function-Form Relations in Cultured Networks * Analyzing the SBEs Motifs * Network Repertoire * Network under Hypothermia * Summary * Acknowledgments * References
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Music and Astronomy Under the Stars - 2009 Update
NASA Astrophysics Data System (ADS)
Lubowich, Donald A.
2010-01-01
Bring telescope to where the people are! Music and Astronomy Under the Stars is a three-year NASA-funded outreach program at parks during and after concerts and family events - a Halloween Spooky Garden Walk. While there have been many outreach activities and telescope observations at city sidewalks and parks, this program targets a completely different audience - music lovers who attend summer concerts held in community parks. These music lovers who may never have visited a science museum, planetarium, or star party are exposed to telescope observations and astronomy information with no additional travel costs. Music and Astronomy Under the Stars increased awareness, engagement, and interest in astronomy at classical, pop, rock, and ethnic music concerts. This program includes solar observing before the concerts, telescope observations including a live image projection system, an astronomical video presentation, and astronomy banners/posters. Approximately 500 - 16,000 people attended each event and 25% to 50% of the people at each event participated in the astronomy program. This program also reached underrepresented and underserved groups (women, minorities, older adults). The target audience is 2,900,000 people, which is larger than combined population of Atlanta, Boston, Denver, Minneapolis, and San Francisco. Although eleven events were planned in 2009, two were canceled due to rain and our largest event, the NY Philharmonic in the Park (attended by 67,000 people in 2008), was cancelled for financial reasons. Our largest event in 2009 was the Tanglewood Music Festival, Lenox MA, attended by 16,000 people where 5000 people participated in astronomy activities. The Amateur Observers' Society of NY assisted with the NY concerts and the Springfield STARS club assisted at Tanglewood. 1500 people looked through telescopes at the Halloween program (6000 saw the posters). In 2009 over 15,000 people participated in these astronomy activities which were attended by approximately 50,000 people.
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Music and Astronomy Under the Stars 2009
NASA Astrophysics Data System (ADS)
Lubowich, D.
2010-08-01
Bring telescopes to where the people are! Music and Astronomy Under the Stars is a three-year NASA-funded astronomy outreach program at community parks during and after music concerts and outdoor family events—such as a Halloween Stars-Spooky Garden Walk. While there have been many astronomy outreach activities and telescope observations at city sidewalks and parks, this program targets a completely different audience: music lovers who are attending summer concerts held in community parks. These music lovers who may never have visited a science museum, planetarium, or star party are exposed to telescope observations and astronomy information with no additional travel costs. Music and Astronomy Under the Stars increased awareness, engagement, and interest in astronomy at classical, pop, rock, and ethnic music concerts. This program includes solar observing before the concerts, telescope observations including a live image projection system, an astronomical video presentation, and astronomy banners/posters. Approximately 500-16,000 people attended each event and 25% to 50% of the people at each event participated in the astronomy program. This program also reached underrepresented and underserved groups (women, minorities, older adults). The target audience (Nassau and Suffolk Counties, New York) is 2,900,000 people, which is larger than combined population of Atlanta, Boston, Denver, Minneapolis, and San Francisco. Although eleven events were planned in 2009, two were canceled due to rain and our largest event, the NY Philharmonic in the Park (attended by 67,000 people in 2008), was cancelled for financial reasons. Our largest event in 2009 was the Tanglewood Music Festival, Lenox MA, attended by 16,000 people where over 5000 people participated in astronomy activities. The Amateur Observers' Society of New York assisted with the NY concerts and the Springfield STARS astronomy club assisted at Tanglewood. In 2009 over 15,000 people participated in astronomy activities at these events which were attended by approximately 50,000 people.
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Chronology: MSFC Space Station program, 1982 - present. Major events
NASA Technical Reports Server (NTRS)
Whalen, Jessie E. (Compiler); Mckinley, Sarah L. (Compiler); Gates, Thomas G. (Compiler)
1988-01-01
The Marshall Space Flight Center (MSFC) maintains an active program to capture historical information and documentation on the MSFC's roles regarding Space Shuttle and Space Station. Marshall History Report 12, called Chronology: MSFC Space Station Program, 1982-Present, is presented. It contains synopses of major events listed according to the dates of their occurrence. Indices follow the synopses and provide additional data concerning the events listed. The Event Index provides a brief listing of all the events without synopses. The Element Index lists the specific elements of the Space Station Program under consideration in the events. The Location Index lists the locations where the events took place. The indices and synopses may be cross-referenced by using dates.
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A Bayes linear Bayes method for estimation of correlated event rates.
Quigley, John; Wilson, Kevin J; Walls, Lesley; Bedford, Tim
2013-12-01
Typically, full Bayesian estimation of correlated event rates can be computationally challenging since estimators are intractable. When estimation of event rates represents one activity within a larger modeling process, there is an incentive to develop more efficient inference than provided by a full Bayesian model. We develop a new subjective inference method for correlated event rates based on a Bayes linear Bayes model under the assumption that events are generated from a homogeneous Poisson process. To reduce the elicitation burden we introduce homogenization factors to the model and, as an alternative to a subjective prior, an empirical method using the method of moments is developed. Inference under the new method is compared against estimates obtained under a full Bayesian model, which takes a multivariate gamma prior, where the predictive and posterior distributions are derived in terms of well-known functions. The mathematical properties of both models are presented. A simulation study shows that the Bayes linear Bayes inference method and the full Bayesian model provide equally reliable estimates. An illustrative example, motivated by a problem of estimating correlated event rates across different users in a simple supply chain, shows how ignoring the correlation leads to biased estimation of event rates. © 2013 Society for Risk Analysis.
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Preliminary fMRI findings on the effects of event rate in adults with ADHD.
Kooistra, Libbe; van der Meere, Jaap J; Edwards, Jodi D; Kaplan, Bonnie J; Crawford, Susan; Goodyear, Bradley G
2010-05-01
Inhibition problems in attention deficit hyperactivity disorder (ADHD) are sensitive to stimulus event rate. This pilot study explores the neural basis of this increased susceptibility to event rate in ADHD. Event-related functional magnetic resonance imaging was used in conjunction with the administration of a fast (1.5 s) and a slow (7 s) Go/No-Go task. Brain activity patterns and reaction times of ten young male adults with ADHD (two of whom were in partial remission) and ten healthy male controls were compared. The ADHD group responded slower than controls with greater variability but with similar number of errors. Accurate response inhibition in the ADHD group in the slow condition was associated with widespread fronto-striatal activation, including the thalamus. For correct Go trials only, the ADHD group compared with controls showed substantial under-activation in the slow condition. The observed abnormal brain activation in the slow condition in adults with ADHD supports a fronto-striatal etiology, and underlines a presumed activation regulation deficit. Larger sample sizes to further validate these preliminary findings are needed.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-04
...; (2) events that happen infrequently but have the potential for high consequences (e.g., a train in... consequence from occurring. Such information is used to develop new training programs, identify root causes of... are submitted when there is a qualifying event, i.e., a close call occurs within a pilot site. The...
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ERIC Educational Resources Information Center
Hirai, Masahiro; Hiraki, Kazuo
2006-01-01
We investigated how the spatiotemporal structure of animations of biological motion (BM) affects brain activity. We measured event-related potentials (ERPs) during the perception of BM under four conditions: normal spatial and temporal structure; scrambled spatial and normal temporal structure; normal spatial and scrambled temporal structure; and…
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Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells.
Yokota, N; Koizume, S; Miyagi, E; Hirahara, F; Nakamura, Y; Kikuchi, K; Ruf, W; Sakuma, Y; Tsuchiya, E; Miyagi, Y
2009-12-15
Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to activation of the extrinsic coagulation cascade. fVII is produced by the liver and believed to be supplied from blood plasma at the site of coagulation. However, we recently showed that ovarian cancer cells express fVII transcripts under normoxia and that this transcription is inducible under hypoxia. These findings led us to hypothesise that ovarian cancer cells are intrinsically associated with TF-fVIIa coagulation activity, which could result in thrombosis. In this study, we examined whether ectopically expressed fVII could cause thrombosis by means of immunohistochemistry, RT-PCR, western blotting and flow cytometry. Ectopic fVII expression occurs frequently in ovarian cancers, particularly in clear cell carcinoma. We further showed that ovarian cancer cells express TF-fVIIa on the cell surface under normoxia and that this procoagulant activity is enhanced by hypoxic stimuli. Moreover, we showed that ovarian cancer cells secrete microparticles (MPs) with TF-fVIIa activity. Production of this procoagulant secretion is enhanced under hypoxia. These results raise the possibility that cancer cell-derived TF-fVIIa could cause thrombotic events in ovarian cancer patients.
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NASA Astrophysics Data System (ADS)
Ye, H.; Fetzer, E. J.; Wong, S.; Lambrigtsen, B.; Wang, T.; Chen, L. L.; Von, D.
2015-12-01
This study uses historical records of synoptic observations over northern Eurasia to examine changing frequency of precipitation associated with large synoptic events versus convective and thunderstorm activities. We found days associated with showers and precipitation accompanied by thunderstorms have been increasing in general during the study period of 1966-2000 while the total wet day frequency has been decreasing in all seasons. This study suggests increasing convective and severe weather-related precipitation events may be a significant contributor to higher intensity and more extreme precipitation under a warming climate.
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NASA Astrophysics Data System (ADS)
Meng, Qingbin; Zhang, Mingwei; Han, Lijun; Pu, Hai; Chen, Yanlong
2018-04-01
To explore the acoustic emission (AE) characteristics of rock materials during the deformation and failure process under periodic loads, a uniaxial cyclic loading and unloading compression experiment was conducted based on an MTS 815 rock mechanics test system and an AE21C acoustic emissions test system. The relationships among stress, strain, AE activity, accumulated AE activity and duration for 180 rock specimens under 36 loading and unloading rates were established. The cyclic AE evolutionary laws with rock stress-strain variation at loading and unloading stages were analyzed. The Kaiser and Felicity effects of rock AE activity were disclosed, and the impact of the significant increase in the scale of AE events on the Felicity effect was discussed. It was observed that the AE characteristics are closely related to the stress-strain properties of rock materials and that they are affected by the developmental state and degree of internal microcracks. AE events occur in either the loading or unloading stages if the strain is greater than zero. Evolutionary laws of AE activity agree with changes in rock strain. Strain deformation is accompanied by AE activity, and the density and intensity of AE events directly reflect the damage degree of the rock mass. The Kaiser effect exists in the linear elastic stage of rock material, and the Felicity effect is effective in the plastic yield and post-peak failure stages, which are divided by the elastic yield strength. This study suggests that the stress level needed to determine a significant increase in AE activity was 70% of the i + 1 peak stress. The Felicity ratio of rock specimens decreases with the growth of loading-unloading cycles. The cycle magnitude and variation of the Felicity effect, in which loading and unloading rates play a weak role, are almost consistent.
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Code of Federal Regulations, 2013 CFR
2013-04-01
... AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.532 What are the...) Limit the availability of payments under NAHASDA to programs, projects, or activities not affected by... of NAHASDA or these regulations is not a pattern or practice of activities constituting willful...
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Code of Federal Regulations, 2014 CFR
2014-04-01
... AMERICAN HOUSING ACTIVITIES Recipient Monitoring, Oversight and Accountability § 1000.532 What are the...) Limit the availability of payments under NAHASDA to programs, projects, or activities not affected by... of NAHASDA or these regulations is not a pattern or practice of activities constituting willful...
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Impact of repeated single-metal and multi-metal pollution events on soil quality.
Burges, Aritz; Epelde, Lur; Garbisu, Carlos
2015-02-01
Most frequently, soil metal pollution results from the occurrence of repeated single-metal and, above all, multi-metal pollution events, with concomitant adverse consequences for soil quality. Therefore, in this study, we evaluated the impact of repeated single-metal and multi-metal (Cd, Pb, Cu, Zn) pollution events on soil quality, as reflected by the values of a variety of soil microbial parameters with potential as bioindicators of soil functioning. Specifically, parameters of microbial activity (potentially mineralizable nitrogen, β-glucosidase and acid phosphatase activity) and biomass (fungal and bacterial gene abundance by RT-qPCR) were determined, in the artificially metal-polluted soil samples, at regular intervals over a period of 26 weeks. Similarly, we studied the evolution over time of CaCl2-extractable metal fractions, in order to estimate metal bioavailability in soil. Different metals showed different values of bioavailability and relative bioavailability ([metal]bio/[metal]tot) in soil throughout the experiment, under both repeated single-metal and multi-metal pollution events. Both repeated Zn-pollution and multi-metal pollution events led to a significant reduction in the values of acid phosphatase activity, and bacterial and fungal gene abundance, reflecting the negative impact of these repeated events on soil microbial activity and biomass, and, hence, soil quality. Copyright © 2014 Elsevier Ltd. All rights reserved.
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Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence
NASA Technical Reports Server (NTRS)
Tlsty, T. D.; Romanov, S. R.; Kozakiewicz, B. K.; Holst, C. R.; Haupt, L. M.; Crawford, Y. G.
2001-01-01
The genomic changes that foster cancer can be either genetic or epigenetic in nature. Early studies focused on genetic changes and how mutational events contribute to changes in gene expression. These point mutations, deletions and amplifications are known to activate oncogenes and inactivate tumor suppressor genes. More recently, multiple epigenetic changes that can have a profound effect on carcinogenesis have been identified. These epigenetic events, such as the methylation of promoter sequences in genes, are under active investigation. In this review we will describe a methylation event that occurs during the propagation of human mammary epithelial cells (HMEC) in culture and detail the accompanying genetic alterations that have been observed.
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Magmatic dyking and recharge in the Asal Rift, Republic of Djibouti
NASA Astrophysics Data System (ADS)
Peltzer, G.; Harrington, J.; Doubre, C.; Tomic, J.
2012-12-01
The Asal Rift, Republic of Djibouti, has been the locus of a major magmatic event in 1978 and seems to have maintained a sustained activity in the three decade following the event. We compare the dyking event of 1978 with the magmatic activity occurring in the rift during the 1997-2008 time period. We use historical air photos and satellite images to quantify the horizontal opening on the major faults activated in 1978. These observations are combined with ground based geodetic data acquired between 1973 and 1979 across the rift to constrain a kinematic model of the 1978 rifting event, including bordering faults and mid-crustal dykes under the Asal Rift and the Ghoubbet Gulf. The model indicates that extension was concentrated between the surface and a depth of 3 km in the crust, resulting in the opening of faults, dykes and fissures between the two main faults, E and gamma, and that the structure located under the Asal Rift, below 3 km, deflated. These results suggest that, during the 1978 event, magmatic fluids transferred from a mid-crustal reservoir to the shallow structures, injecting dykes and filling faults and fissures, and reaching the surface in the Ardoukoba fissural eruption. Surface deformation observed by InSAR during the 1997-2008 decade reveals a slow, yet sustained inflation and extension across the Asal Rift combined with continuous subsidence of the rift inner floor. Modeling shows that these observations cannot be explained by visco-elastic relaxation, a process, which mostly vanishes 20 to 30 years after the 1978 event. However, the InSAR observations over this decade are well explained by a kinematic model in which an inflating body is present at mid-crustal depth, approximately under the Fieale caldera, and shallow faults accommodate both horizontal opening and down-dip slip. The total geometric moment rate, or inflation rate, due to the opening of the mid-crustal structure and the deeper parts of the opening faults is 3 106 m3yr. Such a volume change per year corresponds to 1-2% of the total volume of magma estimated to have been mobilized during the 1978 seismo-magmatic event. The comparison of the 1978-dyking and post-dyking models of rift suggests that the source of the injected magma during the 1978 event lies at mi-crustal depth under the Fieale caldera and appears to be recharging at a sustained rate more than 20 years after the event. Whether this rate is a transient rate or a long-term rate will determine the time of the next magma injection in the shallow crust. However, at the current rate, the 1978 total volume would be replenished in 50-100 years.
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Lecture No More! Creative Ways to Engage New Audiences and Encourage Dialogue
NASA Astrophysics Data System (ADS)
Diederick, L.; Paul, V. J.
2016-02-01
For almost five years, COSEE Florida has been experimenting with new and creative ways of engaging ocean scientists with dialogue-driven outreach events. From science cafes and science festivals to science trivia nights and guerrilla-style events, COSEE Florida has been actively pursuing new ways of reaching under-tapped audiences. This presentation will highlight various models of outreach events - including both homeruns and failures to launch - and will share lessons learned and feedback from both ocean scientist and audience participants.
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Aaboud, M.; Aad, G.; Abbott, B.; ...
2017-03-29
We present charged-particle distributions sensitive to the underlying event, measured by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV, in low-luminosity Large Hadron Collider fills corresponding to an integrated luminosity of 1.6 nb –1. The distributions were constructed using charged particles with absolute pseudorapidity less than 2.5 and with transverse momentum greater than 500 MeV, in events with at least one such charged particle with transverse momentum above 1 GeV. These distributions characterise the angular distribution of energy and particle flows with respect to the charged particle with highest transverse momentum, as a function ofmore » both that momentum and of charged-particle multiplicity. The results have been corrected for detector effects and are compared to the predictions of various Monte Carlo event generators, experimentally establishing the level of underlying-event activity at LHC Run 2 energies and providing inputs for the development of event generator modelling. The current models in use for UE modelling typically describe this data to 5% accuracy, compared with data uncertainties of less than 1%.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aaboud, M.; Aad, G.; Abbott, B.
We present charged-particle distributions sensitive to the underlying event, measured by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV, in low-luminosity Large Hadron Collider fills corresponding to an integrated luminosity of 1.6 nb –1. The distributions were constructed using charged particles with absolute pseudorapidity less than 2.5 and with transverse momentum greater than 500 MeV, in events with at least one such charged particle with transverse momentum above 1 GeV. These distributions characterise the angular distribution of energy and particle flows with respect to the charged particle with highest transverse momentum, as a function ofmore » both that momentum and of charged-particle multiplicity. The results have been corrected for detector effects and are compared to the predictions of various Monte Carlo event generators, experimentally establishing the level of underlying-event activity at LHC Run 2 energies and providing inputs for the development of event generator modelling. The current models in use for UE modelling typically describe this data to 5% accuracy, compared with data uncertainties of less than 1%.« less
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ACTIVE: Activity Concept Transitions in Video Event Classification (Open Access)
2014-03-03
responses are listed under each event. [2] R.- E . Fan, K.-W. Chang, C.-J. Hsieh, X.-R. Wang, and C.-J. Lin. LIBLINEAR: A library for large linear...Laptev, M. Marszalek, C. Schmid, and B. Rozenfeld. Learning realistic human actions from movies. In CVPR, 2008. 1 [11] L.-J. Li, H. Su, E . P. Xing, and F...invariant keypoints. IJCV, 60(2):91–110, 2004. 1, 2 [14] P. Natarajan, S. Vitaladevuni, U. Park, S. Wu, V. Manohar, X. Zhuang, S. Tsakalidis , R. Prasad, and P
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Are triggering rates of labquakes universal? Inferring triggering rates from incomplete information
NASA Astrophysics Data System (ADS)
Baró, Jordi; Davidsen, Jörn
2017-12-01
The acoustic emission activity associated with recent rock fracture experiments under different conditions has indicated that some features of event-event triggering are independent of the details of the experiment and the materials used and are often even indistinguishable from tectonic earthquakes. While the event-event triggering rates or aftershock rates behave pretty much identical for all rock fracture experiments at short times, this is not the case for later times. Here, we discuss how these differences can be a consequence of the aftershock identification method used and show that the true aftershock rates might have two distinct regimes. Specifically, tests on a modified Epidemic-Type Aftershock Sequence model show that the model rates cannot be correctly inferred at late times based on temporal information only if the activity rates or the branching ratio are high. We also discuss both the effect of the two distinct regimes in the aftershock rates and the effect of the background rate on the inter-event time distribution. Our findings should be applicable for inferring event-event triggering rates for many other types of triggering and branching processes as well.
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Ford, Jaclyn Hennessey; Addis, Donna Rose; Giovanello, Kelly S.
2011-01-01
Previous neuroimaging studies that have examined autobiographical memory specificity have utilized retrieval cues associated with prior searches of the event, potentially changing the retrieval processes being investigated. In the current study, musical cues were used to naturally elicit memories from multiple levels of specificity (i.e., lifetime period, general event, and event-specific). Sixteen young adults participated in a neuroimaging study in which they retrieved autobiographical memories associated with musical cues. These musical cues led to the retrieval of highly emotional memories that had low levels of prior retrieval. Retrieval of all autobiographical memory levels was associated with activity in regions in the autobiographical memory network, specifically the ventromedial prefrontal cortex, posterior cingulate, and right medial temporal lobe. Owing to the use of music, memories from varying levels of specificity were retrieved, allowing for comparison of event memory and abstract personal knowledge, as well as comparison of specific and general event memory. Dorsolateral and dorsomedial prefrontal regions were engaged during event retrieval relative to personal knowledge retrieval, and retrieval of specific event memories was associated with increased activity in the bilateral medial temporal lobe and dorsomedial prefrontal cortex relative to retrieval of general event memories. These results suggest that the initial search processes for memories of different specificity levels preferentially engage different components of the autobiographical memory network. The potential underlying causes of these neural differences are discussed. PMID:21600227
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-24
...] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Guidance for Industry on Postmarketing Adverse Event Reporting for Nonprescription Human Drug... has been submitted to the Office of Management and Budget (OMB) for review and clearance under the...
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ERIC Educational Resources Information Center
Liu, Hongyan; Hu, Zhiguo; Peng, Danling; Yang, Yanhui; Li, Kuncheng
2010-01-01
The brain activity associated with automatic semantic priming has been extensively studied. Thus far there has been no prior study that directly contrasts the neural mechanisms of semantic and affective priming. The present study employed event-related fMRI to examine the common and distinct neural bases underlying conceptual and affective priming…
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A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage.
Kubiak, Jeffrey M; Culyba, Matthew J; Liu, Monica Yun; Mo, Charlie Y; Goulian, Mark; Kohli, Rahul M
2017-11-17
The bacterial SOS stress-response pathway is a pro-mutagenic DNA repair system that mediates bacterial survival and adaptation to genotoxic stressors, including antibiotics and UV light. The SOS pathway is composed of a network of genes under the control of the transcriptional repressor, LexA. Activation of the pathway involves linked but distinct events: an initial DNA damage event leads to activation of RecA, which promotes autoproteolysis of LexA, abrogating its repressor function and leading to induction of the SOS gene network. These linked events can each independently contribute to DNA repair and mutagenesis, making it difficult to separate the contributions of the different events to observed phenotypes. We therefore devised a novel synthetic circuit to unlink these events and permit induction of the SOS gene network in the absence of DNA damage or RecA activation via orthogonal cleavage of LexA. Strains engineered with the synthetic SOS circuit demonstrate small-molecule inducible expression of SOS genes as well as the associated resistance to UV light. Exploiting our ability to activate SOS genes independently of upstream events, we further demonstrate that the majority of SOS-mediated mutagenesis on the chromosome does not readily occur with orthogonal pathway induction alone, but instead requires DNA damage. More generally, our approach provides an exemplar for using synthetic circuit design to separate an environmental stressor from its associated stress-response pathway.
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Cockfield, Jeremy; Su, Kyungmin; Robbins, Kay A.
2013-01-01
Experiments to monitor human brain activity during active behavior record a variety of modalities (e.g., EEG, eye tracking, motion capture, respiration monitoring) and capture a complex environmental context leading to large, event-rich time series datasets. The considerable variability of responses within and among subjects in more realistic behavioral scenarios requires experiments to assess many more subjects over longer periods of time. This explosion of data requires better computational infrastructure to more systematically explore and process these collections. MOBBED is a lightweight, easy-to-use, extensible toolkit that allows users to incorporate a computational database into their normal MATLAB workflow. Although capable of storing quite general types of annotated data, MOBBED is particularly oriented to multichannel time series such as EEG that have event streams overlaid with sensor data. MOBBED directly supports access to individual events, data frames, and time-stamped feature vectors, allowing users to ask questions such as what types of events or features co-occur under various experimental conditions. A database provides several advantages not available to users who process one dataset at a time from the local file system. In addition to archiving primary data in a central place to save space and avoid inconsistencies, such a database allows users to manage, search, and retrieve events across multiple datasets without reading the entire dataset. The database also provides infrastructure for handling more complex event patterns that include environmental and contextual conditions. The database can also be used as a cache for expensive intermediate results that are reused in such activities as cross-validation of machine learning algorithms. MOBBED is implemented over PostgreSQL, a widely used open source database, and is freely available under the GNU general public license at http://visual.cs.utsa.edu/mobbed. Source and issue reports for MOBBED are maintained at http://vislab.github.com/MobbedMatlab/ PMID:24124417
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Cockfield, Jeremy; Su, Kyungmin; Robbins, Kay A
2013-01-01
Experiments to monitor human brain activity during active behavior record a variety of modalities (e.g., EEG, eye tracking, motion capture, respiration monitoring) and capture a complex environmental context leading to large, event-rich time series datasets. The considerable variability of responses within and among subjects in more realistic behavioral scenarios requires experiments to assess many more subjects over longer periods of time. This explosion of data requires better computational infrastructure to more systematically explore and process these collections. MOBBED is a lightweight, easy-to-use, extensible toolkit that allows users to incorporate a computational database into their normal MATLAB workflow. Although capable of storing quite general types of annotated data, MOBBED is particularly oriented to multichannel time series such as EEG that have event streams overlaid with sensor data. MOBBED directly supports access to individual events, data frames, and time-stamped feature vectors, allowing users to ask questions such as what types of events or features co-occur under various experimental conditions. A database provides several advantages not available to users who process one dataset at a time from the local file system. In addition to archiving primary data in a central place to save space and avoid inconsistencies, such a database allows users to manage, search, and retrieve events across multiple datasets without reading the entire dataset. The database also provides infrastructure for handling more complex event patterns that include environmental and contextual conditions. The database can also be used as a cache for expensive intermediate results that are reused in such activities as cross-validation of machine learning algorithms. MOBBED is implemented over PostgreSQL, a widely used open source database, and is freely available under the GNU general public license at http://visual.cs.utsa.edu/mobbed. Source and issue reports for MOBBED are maintained at http://vislab.github.com/MobbedMatlab/
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NASA Astrophysics Data System (ADS)
Smekens, Jean-François; Clarke, Amanda B.; Burton, Michael R.; Harijoko, Agung; Wibowo, Haryo E.
2015-07-01
We present the first measurements of SO2 emissions at Semeru volcano, Indonesia, using an SO2 camera. Activity at Semeru is characterized by quiescent degassing interspersed with short-lived explosive events with low ash burden. The interval between explosions was measured at 32.1 ± 15.7 min in a webcam survey of the volcano between the months of June and December 2013. We distinguish between two types of events: shorter events (type I: 5 min duration) with emissions returning quickly to baseline levels, and longer events (type II: 15 min duration) often showing multiple pulses and a longer period of increased emissions before a return to quiescent levels. Type I events represent > 90% of the activity and release an average of 200-500 kg of SO2 per event. The single type II event we documented with the SO2 camera released a total of 1460 kg of SO2. We estimate the daily average emissions of Semeru to be 21-71 t d- 1 of SO2, amounting to a yearly output of 8-26 Gg (8000-26,000 metric tons), with 35-65% released during explosive events. The time series patterns of degassing are consistent with the existence of a viscous plug at the top of the conduit, which seals the conduit immediately prior to explosive events, causing pressurization of the underlying magma followed by a sudden release of gas and fragmented magma.
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Abundant spontaneous VLFE activities in Cascadia during ETS and inter-ETS time periods
NASA Astrophysics Data System (ADS)
Ghosh, A.; Hutchison, A. A.; Hawthorne, J.
2017-12-01
Very low frequency earthquakes (VLFEs) are discrete seismic events associated with episodic tremor and slip (ETS) events. They are rich in 20-50s energy and depleted in higher frequencies compared to regular local earthquakes of similar magnitudes. VLFEs can be as large as Mw 4.0, and potentially release much more seismic moment than the tremor/LFE activities, making them a critical event determining stress evolution during slow earthquakes [Ghosh et al., 2015]. Their underlying physics and relationship with tremor/LFE, however, are still unclear. In Cascadia, the majority of the VLFEs found so far are clustered near the areas of high geodetic slip during ETS events [Ghosh et al., 2015; Hutchison and Ghosh, 2016]. Interestingly, we found VLFE activity has its own dynamics and can occur independent of tremor/LFE activity. For example, during the 2014 ETS event in northern Cascadia, VLFEs are found to be asynchronous with tremor activity, both in space and time [Hutchison and Ghosh, 2016]. We use a matched filter technique to detect thousands of VLFEs over an ETS-cycle, and perhaps more interestingly, even between ETS events. VLFE activities peak during ETS events, but significant VLFE activity is detected during the inter-ETS time period. Analyses of strainmeter data near the VLFE locations suggest statistically significant strain rate increases during VLFE time periods compared to the background. We suggest that VLFE is a distinct type of seismic radiation different from tremor/LFE, and can operate independently from tremor activities. This is in contrast to a model suggesting that VLFE signals may be a result of many LFE signals arriving at seismic stations in a short time period [Gomberg et al., 2016]. We are making a consistent catalog of VLFE in Cascadia for longer time period. Systematic study of VLFEs is going to provide new insights into the mechanism of slow earthquakes and its relationship with tremor/LFE and slow slip.
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Citizens under Suspicion: Responsive Research with Community under Surveillance
ERIC Educational Resources Information Center
Ali, Arshad Imitaz
2016-01-01
In the 14 years since the 9/11 events, this nation as a whole, and New York City in particular, has escalated its state-sanctioned surveillance in the lives and activities of Muslims in the United States. This qualitative study examines the ramifications of police infiltration and monitoring of Muslim student and community-based organizations.…
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Spatio-temporal foreshock activity during stick-slip experiments of large rock samples
NASA Astrophysics Data System (ADS)
Tsujimura, Y.; Kawakata, H.; Fukuyama, E.; Yamashita, F.; Xu, S.; Mizoguchi, K.; Takizawa, S.; Hirano, S.
2016-12-01
Foreshock activity has sometimes been reported for large earthquakes, and has been roughly classified into the following two classes. For shallow intraplate earthquakes, foreshocks occurred in the vicinity of the mainshock hypocenter (e.g., Doi and Kawakata, 2012; 2013). And for intraplate subduction earthquakes, foreshock hypocenters migrated toward the mainshock hypocenter (Kato, et al., 2012; Yagi et al., 2014). To understand how foreshocks occur, it is useful to investigate the spatio-temporal activities of foreshocks in the laboratory experiments under controlled conditions. We have conducted stick-slip experiments by using a large-scale biaxial friction apparatus at NIED in Japan (e.g., Fukuyama et al., 2014). Our previous results showed that stick-slip events repeatedly occurred in a run, but only those later events were preceded by foreshocks. Kawakata et al. (2014) inferred that the gouge generated during the run was an important key for foreshock occurrence. In this study, we proceeded to carry out stick-slip experiments of large rock samples whose interface (fault plane) is 1.5 meter long and 0.5 meter wide. After some runs to generate fault gouge between the interface. In the current experiments, we investigated spatio-temporal activities of foreshocks. We detected foreshocks from waveform records of 3D array of piezo-electric sensors. Our new results showed that more than three foreshocks (typically about twenty) had occurred during each stick-slip event, in contrast to the few foreshocks observed during previous experiments without pre-existing gouge. Next, we estimated the hypocenter locations of the stick-slip events, and found that they were located near the opposite end to the loading point. In addition, we observed a migration of foreshock hypocenters toward the hypocenter of each stick-slip event. This suggests that the foreshock activity observed in our current experiments was similar to that for the interplate earthquakes in terms of the spatio-temporal pattern. This work was supported by NIED research project "Development of monitoring and forecasting technology for crustal activity", JSPS KAKENHI Grant Number 23340131, and MEXT of Japan, under its Earthquake and Volcano Hazards Observation and Research Program.
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Microseismic data records fault activation before and after a Mw 4.1 induced earthquake
NASA Astrophysics Data System (ADS)
Eyre, T.; Eaton, D. W. S.
2017-12-01
Several large earthquakes (Mw 4) have been observed in the vicinity of the town of Fox Creek, Alberta. These events have been determined to be induced earthquakes related to hydraulic fracturing in the region. The largest of these has a magnitude Mw = 4.1, and is associated with a hydraulic-fracturing treatment close to Crooked Lake, about 30 km west of Fox Creek. The underlying factors that lead to localization of the high numbers of hydraulic fracturing induced events in this area remain poorly understood. The treatment that is associated with the Mw 4.1 event was monitored by 93 shallow three-level borehole arrays of sensors. Here we analyze the temporal and spatial evolution of the microseismic and seismic data recorded during the treatment. Contrary to expected microseismic event clustering parallel to the principal horizontal stress (NE - SW), the events cluster along obvious fault planes that align both NNE - SSW and N - S. As the treatment well is oriented N - S, it appears that each stage of the treatment intersects a new portion of the fracture network, causing seismicity to occur. Focal-plane solutions support a strike-slip failure along these faults, with nodal planes aligning with the microseismic cluster orientations. Each fault segment is activated with a cluster of microseismicity in the centre, gradually extending along the fault as time progresses. Once a portion of a fault is active, further seismicity can be induced, regardless if the present stage is distant from the fault. However, the large events seem to occur in regions with a gap in the microseismicity. Interestingly, most of the seismicity is located above the reservoir, including the larger events. Although a shallow-well array is used, these results are believed to have relatively high depth resolution, as the perforation shots are correctly located with an average error of 26 m in depth. This information contradicts previously held views that large induced earthquakes occur primarily, or even exclusively, in the underlying crystalline basement. The findings can give new insights into the dynamics of induced seismicity related to hydraulic fracturing. Additionally, real-time microseismic monitoring can be used to track the evolution of fault activation as it occurs, and can potentially indicate that large events are possible.
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NASA Astrophysics Data System (ADS)
Ghaleb, Bassam; Hillaire-Marcel, Claude; Ruiz Fernandez, Ana-Carolina; Sanchez Cabeza, Joan-Albert
2016-04-01
Climatic events (e.g. floods, storminess) and management activities (e.g. dredging) may result in the burial or removal and re-suspension of sediments in estuaries and coastal areas. When such sediments are contaminated, such processes may either help restoring better chemical environments or lead to their long-term contamination. Geochemical signatures in surface sediments may help identifying such sedimentological events. However, short-lived isotope data are generally required to set time-constraints on their occurrence. Whereas 210Pb and radioactive fallout isotope contents can help setting time constraints at ~50 to ~100 yr-time scales, natural disequilibria in the 232Th-228Ra-228Th sequence do provide information on processes which occurred within the last 30 yrs, as illustrated in the present study. Box-cored sediments from the Saguenay Fjord and lower estuary of the St. Lawrence (Canada) as well as from estuaries and lagoons from the Sinaloa Coast (Mexico) are used to document the behavior of these isotopes either under relatively steady conditions (St. Lawrence estuary) or under high-frequency extreme climate events (storms and floods; Saguenay Fjord, Coastal Sinaloa). 228Th/232Th activity ratios were determined by chemical extraction of Th and alpha counting of unspiked samples, rapidly after sampling (228Th/232Th). The activity of the intermediate isotope 228Ra was then estimated based on replicate measurements on aliquot samples made a few years later. Under steady conditions, core-top sediment shows an excess in 228Th vs 232Th (AR ~ 1.6), whereas the intermediate 228Ra depicts a deficit vs its parent 232Th (AR ~0.6). Downcore, radioactive decay carries rapidly 228Th-activities to those of the parent 228Ra within about 10 yrs (i.e., ~ 5 half-lives of 228Th), then both move during the next ~20 yrs (~ i.e., ~ 5 half-lives of 228Ra, when added to the 10 yrs of 228Th-excess) towards secular equilibrium with the parent long-lived 232Th. A few algorithms provide simple models governing these processes under relatively high sedimentation rates, i.e., when Ra-diffusion from the sediment towards the water column may be neglected. In sites characterized by extreme sedimentologival events, 228Th/232Th profiles depict departures from this model, thus bearing information on the timing and processes involved. Examples from the Saguenay Fjord (Canada) illustrate the case of fast-deposited layers due to floods, whereas examples from estuaries and coastal areas of Sinaloa show evidence for re-suspension and/or erosion events linked notably to storminess and/or land use changes. In the first case, the fast accumulation of flood layers has sealed most of the early 20th-century contamination, whereas in the second case, erosion and re-suspension events led to either some removal of sediments contaminated by heavy metals, or their secondary release into the environment.
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NASA Technical Reports Server (NTRS)
Holt, James M.; Clanton, Stephen E.
1999-01-01
Results of the International Space Station (ISS) Node 2 Internal Active Thermal Control System (IATCS) gross leakage analysis are presented for evaluating total leakage flowrates and volume discharge caused by a gross leakage event (i.e. open boundary condition). A Systems Improved Numerical Differencing Analyzer and Fluid Integrator (SINDA/FLUINT) thermal hydraulic mathematical model (THMM) representing the Node 2 IATCS was developed to simulate system performance under steady-state nominal conditions as well as the transient flow effects resulting from an open line exposed to ambient. The objective of the analysis was to determine the adequacy of the leak detection software in limiting the quantity of fluid lost during a gross leakage event to within an acceptable level.
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NASA Technical Reports Server (NTRS)
Holt, James M.; Clanton, Stephen E.
2001-01-01
Results of the International Space Station (ISS) Node 2 Internal Active Thermal Control System (IATCS) gross leakage analysis are presented for evaluating total leakage flow rates and volume discharge caused by a gross leakage event (i.e. open boundary condition). A Systems Improved Numerical Differencing Analyzer and Fluid Integrator (SINDA85/FLUINT) thermal hydraulic mathematical model (THMM) representing the Node 2 IATCS was developed to simulate system performance under steady-state nominal conditions as well as the transient flow effect resulting from an open line exposed to ambient. The objective of the analysis was to determine the adequacy of the leak detection software in limiting the quantity of fluid lost during a gross leakage event to within an acceptable level.
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Sampled-data consensus in switching networks of integrators based on edge events
NASA Astrophysics Data System (ADS)
Xiao, Feng; Meng, Xiangyu; Chen, Tongwen
2015-02-01
This paper investigates the event-driven sampled-data consensus in switching networks of multiple integrators and studies both the bidirectional interaction and leader-following passive reaction topologies in a unified framework. In these topologies, each information link is modelled by an edge of the information graph and assigned a sequence of edge events, which activate the mutual data sampling and controller updates of the two linked agents. Two kinds of edge-event-detecting rules are proposed for the general asynchronous data-sampling case and the synchronous periodic event-detecting case. They are implemented in a distributed fashion, and their effectiveness in reducing communication costs and solving consensus problems under a jointly connected topology condition is shown by both theoretical analysis and simulation examples.
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Using Ontologies for the Online Recognition of Activities of Daily Living†
2018-01-01
The recognition of activities of daily living is an important research area of interest in recent years. The process of activity recognition aims to recognize the actions of one or more people in a smart environment, in which a set of sensors has been deployed. Usually, all the events produced during each activity are taken into account to develop the classification models. However, the instant in which an activity started is unknown in a real environment. Therefore, only the most recent events are usually used. In this paper, we use statistics to determine the most appropriate length of that interval for each type of activity. In addition, we use ontologies to automatically generate features that serve as the input for the supervised learning algorithms that produce the classification model. The features are formed by combining the entities in the ontology, such as concepts and properties. The results obtained show a significant increase in the accuracy of the classification models generated with respect to the classical approach, in which only the state of the sensors is taken into account. Moreover, the results obtained in a simulation of a real environment under an event-based segmentation also show an improvement in most activities. PMID:29662011
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Gao, Lin; Zhang, Tongsheng; Wang, Jue; Stephen, Julia
2014-01-01
When connectivity analysis is carried out for event related EEG and MEG, the presence of strong spatial correlations from spontaneous activity in background may mask the local neuronal evoked activity and lead to spurious connections. In this paper, we hypothesized PCA decomposition could be used to diminish the background activity and further improve the performance of connectivity analysis in event related experiments. The idea was tested using simulation, where we found that for the 306-channel Elekta Neuromag system, the first 4 PCs represent the dominant background activity, and the source connectivity pattern after preprocessing is consistent with the true connectivity pattern designed in the simulation. Improving signal to noise of the evoked responses by discarding the first few PCs demonstrates increased coherences at major physiological frequency bands when removing the first few PCs. Furthermore, the evoked information was maintained after PCA preprocessing. In conclusion, it is demonstrated that the first few PCs represent background activity, and PCA decomposition can be employed to remove it to expose the evoked activity for the channels under investigation. Therefore, PCA can be applied as a preprocessing approach to improve neuronal connectivity analysis for event related data. PMID:22918837
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Gao, Lin; Zhang, Tongsheng; Wang, Jue; Stephen, Julia
2013-04-01
When connectivity analysis is carried out for event related EEG and MEG, the presence of strong spatial correlations from spontaneous activity in background may mask the local neuronal evoked activity and lead to spurious connections. In this paper, we hypothesized PCA decomposition could be used to diminish the background activity and further improve the performance of connectivity analysis in event related experiments. The idea was tested using simulation, where we found that for the 306-channel Elekta Neuromag system, the first 4 PCs represent the dominant background activity, and the source connectivity pattern after preprocessing is consistent with the true connectivity pattern designed in the simulation. Improving signal to noise of the evoked responses by discarding the first few PCs demonstrates increased coherences at major physiological frequency bands when removing the first few PCs. Furthermore, the evoked information was maintained after PCA preprocessing. In conclusion, it is demonstrated that the first few PCs represent background activity, and PCA decomposition can be employed to remove it to expose the evoked activity for the channels under investigation. Therefore, PCA can be applied as a preprocessing approach to improve neuronal connectivity analysis for event related data.
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Cui, Borui; Gao, Dian-ce; Xiao, Fu; ...
2016-12-23
This article provides a method in comprehensive evaluation of cost-saving potential of active cool thermal energy storage (CTES) integrated with HVAC system for demand management in non-residential building. The active storage is beneficial by shifting peak demand for peak load management (PLM) as well as providing longer duration and larger capacity of demand response (DR). In this research, a model-based optimal design method using genetic algorithm is developed to optimize the capacity of active CTES aiming for maximizing the life-cycle cost saving concerning capital cost associated with storage capacity as well as incentives from both fast DR and PLM. Inmore » the method, the active CTES operates under a fast DR control strategy during DR events while under the storage-priority operation mode to shift peak demand during normal days. The optimal storage capacities, maximum annual net cost saving and corresponding power reduction set-points during DR event are obtained by using the proposed optimal design method. Lastly, this research provides guidance in comprehensive evaluation of cost-saving potential of CTES integrated with HVAC system for building demand management including both fast DR and PLM.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Cui, Borui; Gao, Dian-ce; Xiao, Fu
This article provides a method in comprehensive evaluation of cost-saving potential of active cool thermal energy storage (CTES) integrated with HVAC system for demand management in non-residential building. The active storage is beneficial by shifting peak demand for peak load management (PLM) as well as providing longer duration and larger capacity of demand response (DR). In this research, a model-based optimal design method using genetic algorithm is developed to optimize the capacity of active CTES aiming for maximizing the life-cycle cost saving concerning capital cost associated with storage capacity as well as incentives from both fast DR and PLM. Inmore » the method, the active CTES operates under a fast DR control strategy during DR events while under the storage-priority operation mode to shift peak demand during normal days. The optimal storage capacities, maximum annual net cost saving and corresponding power reduction set-points during DR event are obtained by using the proposed optimal design method. Lastly, this research provides guidance in comprehensive evaluation of cost-saving potential of CTES integrated with HVAC system for building demand management including both fast DR and PLM.« less
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Intra-seasonal variability of extreme boreal stratospheric polar vortex events and their precursors
NASA Astrophysics Data System (ADS)
Díaz-Durán, Adelaida; Serrano, Encarna; Ayarzagüena, Blanca; Abalos, Marta; de la Cámara, Alvaro
2017-11-01
The dynamical variability of the boreal stratospheric polar vortex has been usually analysed considering the extended winter as a whole or only focusing on December, January and February. Yet recent studies have found intra-seasonal differences in the boreal stratospheric dynamics. In this study, the intra-seasonal variability of anomalous wave activity preceding polar vortex extremes in the Northern Hemisphere is examined using ERA-Interim reanalysis data. Weak (WPV) and strong (SPV) polar vortex events are grouped into early, mid- or late winter sub-periods depending on the onset date. Overall, the strongest (weakest) wave-activity anomalies preceding polar vortex extremes are found in mid- (early) winter. Most of WPV (SPV) events in early winter occur under the influence of east (west) phase of the Quasi-Biennial Oscillation (QBO) and an enhancement (inhibition) of wavenumber-1 wave activity (WN1). Mid- and late winter WPV events are preceded by a strong vortex and an enhancement of WN1 and WN2, but the spatial structure of the anomalous wave activity and the phase of the QBO are different. Prior to mid-winter WPVs the enhancement of WN2 is related to the predominance of La Niña and linked to blockings over Siberia. Mid-winter SPV events show a negative phase of the Pacific-North America pattern that inhibits WN1 injected into the stratosphere. This study suggests that dynamical features preceding extreme polar vortex events in mid-winter should not be generalized to other winter sub-periods.
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A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage
2017-01-01
The bacterial SOS stress-response pathway is a pro-mutagenic DNA repair system that mediates bacterial survival and adaptation to genotoxic stressors, including antibiotics and UV light. The SOS pathway is composed of a network of genes under the control of the transcriptional repressor, LexA. Activation of the pathway involves linked but distinct events: an initial DNA damage event leads to activation of RecA, which promotes autoproteolysis of LexA, abrogating its repressor function and leading to induction of the SOS gene network. These linked events can each independently contribute to DNA repair and mutagenesis, making it difficult to separate the contributions of the different events to observed phenotypes. We therefore devised a novel synthetic circuit to unlink these events and permit induction of the SOS gene network in the absence of DNA damage or RecA activation via orthogonal cleavage of LexA. Strains engineered with the synthetic SOS circuit demonstrate small-molecule inducible expression of SOS genes as well as the associated resistance to UV light. Exploiting our ability to activate SOS genes independently of upstream events, we further demonstrate that the majority of SOS-mediated mutagenesis on the chromosome does not readily occur with orthogonal pathway induction alone, but instead requires DNA damage. More generally, our approach provides an exemplar for using synthetic circuit design to separate an environmental stressor from its associated stress-response pathway. PMID:28826208
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Time scales of biogeochemical and organismal responses to individual precipitation events
NASA Astrophysics Data System (ADS)
von Fischer, J. C.; Angert, A. L.; Augustine, D. J.; Brown, C.; Dijkstra, F. A.; Derner, J. D.; Hufbauer, R. A.; Fierer, N.; Milchunas, D. G.; Moore, J. C.; Steltzer, H.; Wallenstein, M. D.
2010-12-01
In temperate grasslands, spatial and intra-annual variability in the activity of plants and microbes are structured by patterns in the precipitation regime. While the effects of total annual precipitation have been well-explored, the ecological dynamics associated with individual precipitation events have not. Rainfall events induce a short-term pulse of soil respiration that may or may not be followed by stimulation of plant photosynthetic activity and growth. Because the underlying heterotrophic and autotrophic responses are interactive, respond over unique timescales and are sensitive to precipitation magnitude, it remains difficult to predict the hydrologic effects on net CO2 exchange. To develop a better mechanistic understanding of these processes, we conducted a synthetic, multi-investigator experiment to characterize the ecosystem responses to rainfall events of different sizes. Our work was conducted on the Shortgrass Steppe (SGS) LTER site over 7 days in June 2009, using 1cm and 2cm rainfall events, with controls and each treatment replicated 5 times in 2m x 2m plots. Our observations revealed both expected responses of plant activity and soil respiration, and surprising patterns in microbial enzyme activity and soil fauna population densities. Coupled with observed dynamics in 15N partitioning and kinetics, our findings provide empirical timescales for the complex ecological interactions that underlie the ecosystem responses to rainfall events. These results can be used to inform a new generation of ecosystem simulation models to more explicitly consider the time lags and interactions of different functional groups.
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ERIC Educational Resources Information Center
Nauta, Paul, Comp.
This biennial report describes International Federation of Library Associations (IFLA) events and activities in the during 1989-90. They are treated under the following headings: (1) Managerial Aspects, including membership and organization, fund raising, regional offices, publications, and conferences; (2) Divisions, Sections, Round Tables,…
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ERIC Educational Resources Information Center
Long, Trisha Wies
2017-01-01
Adolescents are often disengaged in the learning process, being more focused on social media and self-interest than classroom content. Full circling is a process that can be used to help students collaboratively engage in learning and actively reflect on historical events--especially those that are under reported in history books. In the present…
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Temporal and spectral characteristics of seismicity observed at Popocatepetl volcano, central Mexico
Arciniega-Ceballos, A.; Valdes-Gonzalez, C.; Dawson, P.
2000-01-01
Popocatepetl volcano entered an eruptive phase from December 21, 1994 to March 30, 1995, which was characterized by ash and fumarolic emissions. During this eruptive episode, the observed seismicity consisted of volcano-tectonic (VT) events, long-period (LP) events and sustained tremor. Before the initial eruption on December 21, VT seismicity exhibited no increase in number until a swarm of VT earthquakes was observed at 01:31 hours local time. Visual observations of the eruption occurred at dawn the next morning. LP activity increased from an average of 7 events a day in October 1994 to 22 events per day in December 1994. At the onset of the eruption, LP activity peaked at 49 events per day. LP activity declined until mid-January 1995 when no events were observed. Tremor was first observed about one day after the initial eruption and averaged 10 h per episode. By late February 1995, tremor episodes became more intermittent, lasting less than 5 min, and the number of LP events returned to pre-eruption levels (7 events per day). Using a spectral ratio technique, low-frequency oceanic microseismic noise with a predominant peak around 7 s was removed from the broadband seismic signal of tremor and LP events. Stacks of corrected tremor episodes and LP events show that both tremor and LP events contain similar frequency features with major peaks around 1.4 Hz. Frequency analyses of LP events and tremor suggest a shallow extended source with similar radiation pattern characteristics. The distribution of VT events (between 2.5 and 10 km) also points to a shallow source of the tremor and LP events located in the first 2500 m beneath the crater. Under the assumption that the frequency characteristics of the signals are representative of an oscillator we used a fluid-filled-crack model to infer the length of the resonator.
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Comparing Low-Frequency Earthquakes During Triggered and Ambient Tremor in Taiwan
NASA Astrophysics Data System (ADS)
Alvarado Lara, F., Sr.; Ledezma, C., Sr.
2014-12-01
In South America, larger magnitude seismic events originate in the subduction zone between the Nazca and Continental plates, as opposed to crustal events. Crustal seismic events are important in areas very close to active fault lines; however, seismic hazard analyses incorporate crust events related to a maximum distance from the site under study. In order to use crustal events as part of a seismic hazard analysis, it is necessary to use the attenuation relationships which represent the seismic behavior of the site under study. Unfortunately, in South America the amount of compiled crustal event historical data is not yet sufficient to generate a firm regional attenuation relationship. In the absence of attenuation relationships for crustal earthquakes in the region, the conventional approach is to use attenuation relationships from other regions which have a large amount of compiled data and which have similar seismic conditions to the site under study. This practice permits the development of seismic hazard analysis work with a certain margin of accuracy. In South America, in the engineering practice, new generation attenuation relationships (NGA-W) are used among other alternatives in order to incorporate the effect of crustal events in a seismic hazard analysis. In 2014, the NGA-W Version 2 (NGA-W2) was presented with a database containing information from Taiwan, Turkey, Iran, USA, Mexico, Japan, and Alaska. This paper examines whether it is acceptable to utilize the NGA-W2 in seismic hazard analysis in South America. A comparison between response spectrums of the seismic risk prepared in accordance with NGA-W2 and actual response spectrums of crustal events from Argentina is developed in order to support the examination. The seismic data were gathered from equipment installed in the cities of Santiago, Chile and Mendoza, Argentina.
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Revision of the Applicability of the NGA's in South America, Chile - Argentina.
NASA Astrophysics Data System (ADS)
Alvarado Lara, F., Sr.; Ledezma, C., Sr.
2015-12-01
In South America, larger magnitude seismic events originate in the subduction zone between the Nazca and Continental plates, as opposed to crustal events. Crustal seismic events are important in areas very close to active fault lines; however, seismic hazard analyses incorporate crust events related to a maximum distance from the site under study. In order to use crustal events as part of a seismic hazard analysis, it is necessary to use the attenuation relationships which represent the seismic behavior of the site under study. Unfortunately, in South America the amount of compiled crustal event historical data is not yet sufficient to generate a firm regional attenuation relationship. In the absence of attenuation relationships for crustal earthquakes in the region, the conventional approach is to use attenuation relationships from other regions which have a large amount of compiled data and which have similar seismic conditions to the site under study. This practice permits the development of seismic hazard analysis work with a certain margin of accuracy. In South America, in the engineering practice, new generation attenuation relationships (NGA-W) are used among other alternatives in order to incorporate the effect of crustal events in a seismic hazard analysis. In 2014, the NGA-W Version 2 (NGA-W2) was presented with a database containing information from Taiwan, Turkey, Iran, USA, Mexico, Japan, and Alaska. This paper examines whether it is acceptable to utilize the NGA-W2 in seismic hazard analysis in South America. A comparison between response spectrums of the seismic risk prepared in accordance with NGA-W2 and actual response spectrums of crustal events from Argentina is developed in order to support the examination. The seismic data were gathered from equipment installed in the cities of Santiago, Chile and Mendoza, Argentina.
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DAG1, no gene for RNA regulation?
Brancaccio, Andrea
2012-04-10
DAG1 encodes for a precursor protein that liberates the two subunits featured by the dystroglycan (DG) adhesion complex that are involved in an increasing number of cellular functions in a wide variety of cells and tissues. Aside from the proteolytic events producing the α and β subunits, especially the former undergoes extensive "post-production" modifications taking place within the ER/Golgi where its core protein is both N- and O-decorated with sugars. These post-translational events, that are mainly orchestrated by a plethora of certified, or putative, glycosyltransferases, prelude to the excocytosis-mediated trafficking and targeting of the DG complex to the plasma membrane. Extensive genetic and biochemical evidences have been accumulated so far on α-DG glycosylation, while little is know on possible regulatory events underlying the chromatine activation, transcription or post-transcription (splicing and escape from the nucleus) of DAG1 or of its mRNA. A scenario is envisaged in which cells would use a sort of preferential, and scarcely regulated, route for DAG1 activation, that would imply fast mRNA transcription, maturation and export to the cytosol, and would prelude to the multiple time-consuming enzymatic post-translational activities needed for its glycosylation. Such a provocative view might be helpful to trigger future work aiming at disclosing the complete molecular mechanisms underlying DAG1 activation and at improving our knowledge of any pre-translational step that is involved in dystroglycan regulation. Copyright © 2012 Elsevier B.V. All rights reserved.
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NASA Astrophysics Data System (ADS)
Pontbriand, Claire W.; Sohn, Robert A.
2014-02-01
We detected 32,078 very small, local microearthquakes (average ML = -1) during a 9 month deployment of five ocean bottom seismometers on the periphery of the Trans-Atlantic Geotraverse active mound. Seismicity rates were constant without any main shock-aftershock behavior at ~243 events per day at the beginning of the experiment, 128 events per day after an instrument failed, and 97 events per day at the end of the experiment when whale calls increased background noise levels. The microearthquake seismograms are characterized by durations of <1 s and most have single-phase P wave arrivals (i.e., no S arrivals). We accurately located 6207 of the earthquakes, with hypocenters clustered within a narrow depth interval from ~50 to 125 m below seafloor on the south and west flanks of the deposit. We model the microearthquakes as reaction-driven fracturing events caused by anhydrite deposition in the secondary circulation system of the hydrothermal mound and show that under reasonable modeling assumptions an average event represents a volume increase of 31-58 cm3, yielding an annual (seismogenic) anhydrite deposition rate of 27-51 m3.
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Association of time of occurrence of electrical heart storms with environmental physical activity.
Stoupel, Eliiyahu; Kusniec, Jairo; Golovchiner, Gregory; Abramson, Evgeny; Kadmon, Udi; Strasberg, Boris
2014-08-01
Many publications in recent decades have reported a temporal link between medical events and environmental physical activity. The aim of this study was to analyze the time of occurrence of electrical heart storms against levels of cosmological parameters. The sample included 82 patients (71 male) with ischemic cardiomyopathy treated with an implantable cardioverter defibrillator at a tertiary medical center in 1999-2012 (5,114 days). The time of occurrence of all electrical heart storms, defined as three or more events of ventricular tachycardia or ventricular fibrillation daily, was recorded from the defibrillator devices. Findings were analyzed against data on solar, geomagnetic, and cosmic ray (neutron) activity for the same time period obtained from space institutions in the United States and Russia. Electrical storms occurred in all months of the year, with a slight decrease in July, August, and September. Most events took place on days with lower-than-average levels of solar and geomagnetic activity and higher-than-average levels of cosmic ray (neutron) activity. There was a significant difference in mean daily cosmic ray activity between the whole observation period and the days of electrical storm activity (P = 0.0001). These data extend earlier findings on the association of the timing of cardiac events and space weather parameters to the most dangerous form of cardiac arrhythmia-electric storms. Further studies are needed to delineate the pathogenetic mechanism underlying this association. ©2014 Wiley Periodicals, Inc.
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Disease Activity in Rheumatoid Arthritis and the Risk of Cardiovascular Events
Solomon, DH; Reed, G; Kremer, JM; Curtis, JR; Farkouh, ME; Harrold, LR; Hochberg, MC; Tsao, P; Greenberg, J
2015-01-01
Background Use of several immunomodulatory agents has been associated with reduced cardiovascular (CV) events in epidemiologic studies of rheumatoid arthritis (RA). However, it is unknown whether time-averaged disease activity in RA correlates with CV events. Methods We studied patients with RA followed in a longitudinal US-based registry. Time-averaged disease activity was assessed using the area under the curve of the Clinical Disease Activity Index, a validated measure of rheumatoid arthritis disease activity, assessed during follow-up. Age, gender, diabetes, hypertension, hyperlipidemia, body mass index, family history of myocardial infarction (MI), aspirin use, NSAID use presence of CV disease, and baseline immunomodulator use were assessed at baseline. Cox proportional hazards regression models were examined to determine the risk of a composite CV endpoint that included MI, stroke, and CV death. Results 24,989 subjects followed for a median of 2.7 years were included in these analyses. During follow-up, we observed 422 confirmed CV endpoints for an incidence rate of 9.08 (95% confidence interval, CI, 7.90 – 10.26) per 1,000 person-years. In models adjusting for variables noted above, a 10-point reduction in time-averaged Clinical Disease Activity Index was associated with a 26% reduction in CV risk (95% confidence interval 17-34%). These results were robust in subgroup analyses stratified by presence of CV disease, use of corticosteroids, use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors, change in RA treatment, and also when restricted to events adjudicated as definite or probable. Conclusions Reduced time-averaged disease activity in RA is associated with fewer CV events. PMID:25776112
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Allavena, Giulia; Cuomo, Francesca; Baumgartner, Georg; Bele, Tadeja; Sellgren, Alexander Yarar; Oo, Kyaw Soe; Johnson, Kaylee; Gogvadze, Vladimir; Zhivotovsky, Boris; Kaminskyy, Vitaliy O
2018-01-01
Macroautophagy/autophagy inhibition under stress conditions is often associated with increased cell death. We found that under nutrient limitation, activation of CASP8/caspase-8 was significantly increased in autophagy-deficient lung cancer cells, which precedes mitochondria outer membrane permeabilization (MOMP), CYCS/cytochrome c release, and activation of CASP9/caspase-9, indicating that under such conditions the activation of CASP8 is a primary event in the initiation of apoptosis as well as essential to reduce clonogenic survival of autophagy-deficient cells. Starvation leads to suppression of CFLAR proteosynthesis and accumulation of CASP8 in SQSTM1 puncta. Overexpression of CFLARs reduces CASP8 activation and apoptosis during starvation, while its silencing promotes efficient activation of CASP8 and apoptosis in autophagy-deficient U1810 lung cancer cells even under nutrient-rich conditions. Similar to starvation, inhibition of protein translation leads to efficient activation of CASP8 and cell death in autophagy-deficient lung cancer cells. Thus, here for the first time we report that suppressed translation leads to activation of CASP8-dependent apoptosis in autophagy-deficient NSCLC cells under conditions of nutrient limitation. Our data suggest that targeting translational machinery can be beneficial for elimination of autophagy-deficient cells via the CASP8-dependent apoptotic pathway.
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Pinter, M M; Pogarell, O; Oertel, W H
1999-04-01
Pramipexole, a non-ergot dopamine D2/D3 receptor agonist, was investigated as an add on drug in advanced parkinsonian patients with motor fluctuations to assess efficacy, safety, and tolerance. Seventy eight patients of either sex with advanced Parkinson's disease and treatment complications such as motor fluctuations were enrolled into a double blind, placebo controlled, randomised, multicentre study (phase II) and assigned to add on treatment with pramipexole (n=34) versus placebo (n=44) to a previously stabilised antiparkinsonian medication (7 week dose titration interval, 4 week maintenance period). The primary end point of efficacy was the change from baseline in the total score of the unified Parkinson's disease rating scale (UPDRS) in the on "period" (2 hours after intake of study medication). Safety and tolerability were assessed on the basis of adverse events, vital signs, laboratory measurements, and ECG recordings. There was a significant improvement of the pramipexole group in UPDRS total scores, subscores part II, III (activities of daily living and motor examination), and IV (complications of therapy). Mean UPDRS total score decreased by 37.3% under pramipexole compared with 12.2% under placebo (p<0.001). Patients under pramipexole reported an overall reduction in "off" periods of 12%--resulting in 1.7 more hours "on" time a day--compared with an increase in "off" periods of 2% under placebo. There were no unexpected safety results. The adverse event profile disclosed a high tolerability. The most important adverse events under pramipexole were fatigue, dyskinesia, and vivid dreams. Pramipexole administration is an efficacious and well tolerated add on therapy in patients with advanced Parkinson's disease with an improvement in activities of daily living, motor function, and treatment associated complications.
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Automatic Detection and Classification of Unsafe Events During Power Wheelchair Use.
Pineau, Joelle; Moghaddam, Athena K; Yuen, Hiu Kim; Archambault, Philippe S; Routhier, François; Michaud, François; Boissy, Patrick
2014-01-01
Using a powered wheelchair (PW) is a complex task requiring advanced perceptual and motor control skills. Unfortunately, PW incidents and accidents are not uncommon and their consequences can be serious. The objective of this paper is to develop technological tools that can be used to characterize a wheelchair user's driving behavior under various settings. In the experiments conducted, PWs are outfitted with a datalogging platform that records, in real-time, the 3-D acceleration of the PW. Data collection was conducted over 35 different activities, designed to capture a spectrum of PW driving events performed at different speeds (collisions with fixed or moving objects, rolling on incline plane, and rolling across multiple types obstacles). The data was processed using time-series analysis and data mining techniques, to automatically detect and identify the different events. We compared the classification accuracy using four different types of time-series features: 1) time-delay embeddings; 2) time-domain characterization; 3) frequency-domain features; and 4) wavelet transforms. In the analysis, we compared the classification accuracy obtained when distinguishing between safe and unsafe events during each of the 35 different activities. For the purposes of this study, unsafe events were defined as activities containing collisions against objects at different speed, and the remainder were defined as safe events. We were able to accurately detect 98% of unsafe events, with a low (12%) false positive rate, using only five examples of each activity. This proof-of-concept study shows that the proposed approach has the potential of capturing, based on limited input from embedded sensors, contextual information on PW use, and of automatically characterizing a user's PW driving behavior.
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Analysis of Actin-Based Intracellular Trafficking in Pollen Tubes.
Jiang, Yuxiang; Zhang, Meng; Huang, Shanjin
2017-01-01
Underlying rapid and directional pollen tube growth is the active intracellular trafficking system that carries materials necessary for cell wall synthesis and membrane expansion to the expanding point of the pollen tube. The actin cytoskeleton has been shown to control various intracellular trafficking events in the pollen tube, but the underlying cellular and molecular mechanisms remain poorly understood. To better understand how the actin cytoskeleton is involved in the regulation of intracellular trafficking events, we need to establish assays to visualize and quantify the distribution and dynamics of organelles, vesicles, or secreted proteins. In this chapter, we introduce methods regarding the visualization and quantification of the distribution and dynamics of organelles or vesicles in pollen tubes.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-30
... inverse performance of an underlying index, indexes or Reference Asset; however, in no event will a loss... which a registered Market Maker, directly or indirectly, controls trading activities, or has a direct...
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Active and passive surveillance of enoxaparin generics: a case study relevant to biosimilars.
Grampp, Gustavo; Bonafede, Machaon; Felix, Thomas; Li, Edward; Malecki, Michael; Sprafka, J Michael
2015-03-01
This retrospective analysis assessed the capability of active and passive safety surveillance systems to track product-specific safety events in the USA for branded and generic enoxaparin, a complex injectable subject to immune-related and other adverse events (AEs). Analysis of heparin-induced thrombocytopenia (HIT) incidence was performed on benefit claims for commercial and Medicare supplemental-insured individuals newly treated with enoxaparin under pharmacy benefit (1 January 2009 - 30 June 2012). Additionally, spontaneous reports from the FDA AE Reporting System were reviewed to identify incidence and attribution of enoxaparin-related reports to specific manufacturers. Specific, dispensed products were identifiable from National Drug Codes only in pharmacy-benefit databases, permitting sensitive comparison of HIT incidence in nearly a third of patients treated with brand or generic enoxaparin. After originator medicine's loss of exclusivity, only 5% of spontaneous reports were processed by generic manufacturers; reports attributable to specific generics were approximately ninefold lower than expected based on market share. Claims data were useful for active surveillance of enoxaparin generics dispensed under pharmacy benefits but not for products administered under medical benefits. These findings suggest that the current spontaneous reporting system will not distinguish product-specific safety signals for products distributed by multiple manufacturers, including biosimilars.
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Vasconcelos, Marta; Eckert, Helene; Arahana, Venancio; Graef, George; Grusak, Michael A; Clemente, Tom
2006-10-01
Soybean (Glycine max Merr.) production is reduced under iron-limiting calcareous soils throughout the upper Midwest regions of the US. Like other dicotyledonous plants, soybean responds to iron-limiting environments by induction of an active proton pump, a ferric iron reductase and an iron transporter. Here we demonstrate that heterologous expression of the Arabidopsis thaliana ferric chelate reductase gene, FRO2, in transgenic soybean significantly enhances Fe(+3) reduction in roots and leaves. Root ferric reductase activity was up to tenfold higher in transgenic plants and was not subjected to post-transcriptional regulation. In leaves, reductase activity was threefold higher in the transgenic plants when compared to control. The enhanced ferric reductase activity led to reduced chlorosis, increased chlorophyll concentration and a lessening in biomass loss in the transgenic events between Fe treatments as compared to control plants grown under hydroponics that mimicked Fe-sufficient and Fe-deficient soil environments. However, the data indicate that constitutive FRO2 expression under non-iron stress conditions may lead to a decrease in plant productivity as reflected by reduced biomass accumulation in the transgenic events under non-iron stress conditions. When grown at Fe(III)-EDDHA levels greater than 10 microM, iron concentration in the shoots of transgenic plants was significantly higher than control. The same observation was found in the roots in plants grown at iron levels higher than 32 microM Fe(III)-EDDHA. These results suggest that heterologous expression of an iron chelate reductase in soybean can provide a route to alleviate iron deficiency chlorosis.
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Miller, C. Dan; Sushyar, R.; ,; Hamidi, S.
1983-01-01
The Dieng Mountains region consists of a complex of late Quaternary to recent volcanic stratocones, parasitic vents, and explosion craters. Six age groups of volcanic centers, eruptive products, and explosion craters are recognized in the region based on their morphology, degree of dissection, stratigraphic relationships, and degree of weathering. These features range in age from tens of thousands of years to events that have occurred this century. No magmatic eruptions have occurred in the Dieng Mountains region for at least several thousand years; volcanic activity during this time interval has consisted of phreatic eruptions and non-explosive hydrothermal activity. If future volcanic events are similar to those of the last few thousand years, they will consist of phreatic eruptions, associated small hot mudflows, emission of suffocating gases, and hydrothermal activity. Future phreatic eruptions may follow, or accompany, periods of increased earthquake activity; the epicenters for the seismicity may suggest where eruptive activity will occur. Under such circumstances, the populace within several kilometers of a potential eruption site should be warned of a possible eruption, given instructions about what to do in the event of an eruption, or temporarily evacuated to a safer location.
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Mechanisms Underlying the Active Self-Assembly of Microtubule Rings and Spools.
VanDelinder, Virginia; Brener, Stephanie; Bachand, George D
2016-03-14
Active self-assembly offers a powerful route for the creation of dynamic multiscale structures that are presently inaccessible with standard microfabrication techniques. One such system uses the translation of microtubule filaments by surface-tethered kinesin to actively assemble nanocomposites with bundle, ring, and spool morphologies. Attempts to observe mechanisms involved in this active assembly system have been hampered by experimental difficulties with performing observation during buffer exchange and photodamage from fluorescent excitation. In the present work, we used a custom microfluidic device to remove these limitations and directly study ring/spool formation, including the earliest events (nucleation) that drive subsequent nanocomposite assembly. Three distinct formation events were observed: pinning, collisions, and induced curvature. Of these three, collisions accounted for the majority of event leading to ring/spool formation, while the rate of pinning was shown to be dependent on the amount of photodamage in the system. We further showed that formation mechanism directly affects the diameter and rotation direction of the resultant rings and spools. Overall, the fundamental understanding described in this work provides a foundation by which the properties of motor-driven, actively assembled nanocomposites may be tailored toward specific applications.
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Mechanisms underlying the active self-assembly of microtubule rings and spools
VanDelinder, Virginia; Brener, Stephanie; Bachand, George D.
2016-02-04
Here, active self-assembly offers a powerful route for the creation of dynamic multiscale structures that are presently inaccessible with standard microfabrication techniques. One such system uses the translation of microtubule filaments by surface-tethered kinesin to actively assemble nanocomposites with bundle, ring, and spool morphologies. Attempts to observe mechanisms involved in this active assembly system have been hampered by experimental difficulties with performing observation during buffer exchange and photodamage from fluorescent excitation. In the present work, we used a custom microfluidic device to remove these limitations and directly study ring/spool formation, including the earliest events (nucleation) that drive subsequent nanocomposite assembly.more » Three distinct formation events were observed: pinning, collisions, and induced curvature. Of these three, collisions accounted for the majority of event leading to ring/spool formation, while the rate of pinning was shown to be dependent on the amount of photodamage in the system. We further showed that formation mechanism directly affects the diameter and rotation direction of the resultant rings and spools. Overall, the fundamental understanding described in this work provides a foundation by which the properties of motor-driven, actively assembled nanocomposites may be tailored toward specific applications.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Frandsen, K.
In the event of a major radiological incident, the Federal Radiological Monitoring and Assessment Center (FRMAC) will coordinate the federal agencies that have various statutory responsibilities. The FRMAC is responsible for coordinating all environmental radiological monitoring, sampling, and assessment activities for the response. This manual describes the FRMAC’s response activities in a radiological incident. It also outlines how FRMAC fits in the National Incident Management System (NIMS) under the National Response Framework (NRF) and describes the federal assets and subsequent operational activities which provide federal radiological monitoring and assessment of the affected areas. In the event of a potential ormore » existing major radiological incident, the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) is responsible for establishing and managing the FRMAC during the initial phases.« less
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Aftershocks and triggering processes in rock fracture
NASA Astrophysics Data System (ADS)
Davidsen, J.; Kwiatek, G.; Goebel, T.; Stanchits, S. A.; Dresen, G.
2017-12-01
One of the hallmarks of our understanding of seismicity in nature is the importance of triggering processes, which makes the forecasting of seismic activity feasible. These triggering processes by which one earthquake induces (dynamic or static) stress changes leading to potentially multiple other earthquakes are at the core relaxation processes. A specic example of triggering are aftershocks following a large earthquake, which have been observed to follow certain empirical relationships such as the Omori-Utsu relation. Such an empirical relation should arise from the underlying microscopic dynamics of the involved physical processes but the exact connection remains to be established. Simple explanations have been proposed but their general applicability is unclear. Many explanations involve the picture of an earthquake as a purely frictional sliding event. Here, we present experimental evidence that these empirical relationships are not limited to frictional processes but also arise in fracture zone formation and are mostly related to compaction-type events. Our analysis is based on tri-axial compression experiments under constant displacement rate on sandstone and granite samples using spatially located acoustic emission events and their focal mechanisms. More importantly, we show that event-event triggering plays an important role in the presence of large-scale or macrocopic imperfections while such triggering is basically absent if no signicant imperfections are present. We also show that spatial localization and an increase in activity rates close to failure do not necessarily imply triggering behavior associated with aftershocks. Only if a macroscopic crack is formed and its propagation remains subcritical do we observe significant triggering.
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76 FR 35511 - Decommissioning Planning
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-17
..., which includes the site's subsurface soil and groundwater. Licensees also may be required to perform... structures, materials, soils, groundwater, and other media at a site resulting from activities under the.... Certain operational events (e.g., slow, long-term leaks), particularly those that cause subsurface soil...
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NASA Astrophysics Data System (ADS)
Trifonova, Tatiana; Tulenev, Nikita; Trifonov, Dmitriy; Arakelian, Sergei
2014-05-01
1. Surface water and groundwater interaction model under conditions of huge level of precipitation in catastrophic floods and mudflows for mountain river watershed is introduced. Seismic processes and volcanic activity impact on the formation of disastrous floods due to dramatic change of the pressure field in groundwater horizons, is under discussion for such a triple coupling system, i.e. surface water - groundwater - crack network. Under the conception we analyze recent (2013) catastrophic water events: the catastrophic floods in Western Europe (May-June, 2013), in the Amur river basin, Russia/China (Aug.-Sept, 2013) and in Colorado, USA (Sept. 12-15,2013). In addition, a separate analysis is carried out for debris event in the Krimsk-city, Caucasus (Krasnodar) region, Russia (July 06-07, 2012). 2. There is a group of problems determined by dramatic discrepancies in water mass balance and other vital parameters, on the one hand, by estimation for different types of atmospheric precipitation (both torrential rain and continuous precipitations) and, on the other hand, for observable natural water events (i.e. catastrophic floods and/or mudflows/debris) on concrete territory. Analysis of many facts result in conclusion that we have the hard comparable/coincidence parameters under traditional conception for discussed events as an isolated/closed (river + rain) runoff-system. In contrast, the reasonable point of view does exist if we take into account the contribution of extra water source, which should be localized in river channel, i.e. functioning of open [(river + rain) + groundwater] flow-system has a principal meaning to understand the events occurrence. 3. The analysis and modeling for the events are carried out by us taking into account the following databases: (i) groundwater map dislocation, it resources and flow balance in studied areas, especially near the land surface being unstable in hydrological sense by many reasons, as well due to heavy rain stimulating a trigger mechanism for releasing of groundwater; (ii) the crackness/fracturing structure as a characteristic property for all rocks, being dissecting by totality of cracks/fissures and along which (in the case when a good development crack becomes a fault) a vertical and/or lateral movement (of both groundwater and surface water mass) occurs as a result of excessive strain; (iii) areas of formation and modification in time of groundwater transit system, and especially the modalities for it exit on surface by different factors including tectonic processes under adjustable conditions for both localization of earthquake epicenters/volcanos activity areas and occurring floods in respect of propagating of seismic waves and dislocation of border for lithospheric plates/magma objects in the river basin region; (iv) the way of distribution over surface for water flows/fronts in the further, which can be described by nonlinear hydrodynamic approach, e.g. by different classes of solutions for Korteweg-de Vries equation, associated with observable natural phenomena. 4. Monitoring in dynamics of state of hydrostatic/hydrodynamic pressures in underground aquifers (e.g. by artesian wells in comparison with two databases: before and after the events) is an important factor in assessing of acceptable risk for the events. Combining it with monitoring of seismic activity should allow to make a more detailed forecasting and zoning of potentially dangerous areas for such natural disasters.
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Importance of ABA homeostasis under terminal drought stress in regulating grain filling events
Govind, Geetha; Seiler, Christiane; Wobus, Ulrich
2011-01-01
Recent studies suggest that abscisic acid (ABA) at its basal level plays an important role during seed set and grain filling events. Under drought stress ABA levels were found to be significantly enhanced in the developing seed. Until now we lacked an understanding of (1) ABA homeostasis in developing seeds under terminal drought and (2) the interactive role of ABA in regulating the starch biosynthesis pathway in developing grains under terminal drought. We have recently reported the possible regulation of ABA homeostasis in source (flag leaf) and sink (developing grains) tissues under post-anthesis drought stress in barley and concluded that significantly enhanced ABA levels in developing grains are due to strong activation of the ABA deconjugation pathway and fine regulation of the ABA biosynthesis-degradation pathway.1 Additionally, we provided evidence for the role of ABA in differential regulation of starch biosynthesis genes and a significant upregulation of starch degradation beta amylase genes under drought, i.e., ABA not only influences the rate of starch accumulation but also starch quality. PMID:21778825
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Negative Emotion Weakens the Degree of Self-Reference Effect: Evidence from ERPs
Fan, Wei; Zhong, Yiping; Li, Jin; Yang, Zilu; Zhan, Youlong; Cai, Ronghua; Fu, Xiaolan
2016-01-01
We investigated the influence of negative emotion on the degree of self-reference effect using event-related potentials (ERPs). We presented emotional pictures and self-referential stimuli (stimuli that accelerate and improve processing and improve memory of information related to an individual’s self-concept) in sequence. Participants judged the color of the target stimulus (self-referential stimuli). ERP results showed that the target stimuli elicited larger P2 amplitudes under neutral conditions than under negative emotional conditions. Under neutral conditions, N2 amplitudes for highly self-relevant names (target stimulus) were smaller than those for any other names. Under negative emotional conditions, highly and moderately self-referential stimuli activated smaller N2 amplitudes. P3 amplitudes activated by self-referential processing under negative emotional conditions were smaller than neutral conditions. In the left and central sites, highly self-relevant names activated larger P3 amplitudes than any other names. But in the central sites, moderately self-relevant names activated larger P3 amplitudes than non-self-relevant names. The findings indicate that negative emotional processing could weaken the degree of self-reference effect. PMID:27733836
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Playa Soil Moisture and Evaporation Dynamics During the MATERHORN Field Program
NASA Astrophysics Data System (ADS)
Hang, Chaoxun; Nadeau, Daniel F.; Jensen, Derek D.; Hoch, Sebastian W.; Pardyjak, Eric R.
2016-06-01
We present an analysis of field data collected over a desert playa in western Utah, USA in May 2013, the most synoptically active month of the year, as part of the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) program. The results show that decreasing surface albedo, decreasing Bowen ratio and increasing net radiation with increasing soil moisture sustained a powerful positive feedback mechanism promoting large evaporation rates immediately following rain events. Additionally, it was found that, while nocturnal evaporation was negligible during dry periods, it was quite significant (up to 30 % of the daily cumulative flux) during nights following rain events. Our results further show that the highest spatial variability in surface soil moisture is found under dry conditions. Finally, we report strong spatial heterogeneities in evaporation rates following a rain event. The cumulative evaporation for the different sampling sites over a five-day period varied from ≈ 0.1 to ≈ 6.6 mm. Overall, this study allows us to better understand the mechanisms underlying soil moisture dynamics of desert playas as well as evaporation following occasional rain events.
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Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.
Maciejewski, Mateusz; Lounkine, Eugen; Whitebread, Steven; Farmer, Pierre; DuMouchel, William; Shoichet, Brian K; Urban, Laszlo
2017-08-08
The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and artefactual trends. To address these problems, we mapped drugs to their ingredients and used natural language processing to classify and correlate drug events. Our analysis exposed key idiosyncrasies in FAERS, for example reports of thalidomide causing a deadly ADR when used against myeloma, a likely result of the disease itself; multiplications of the same report, unjustifiably increasing its importance; correlation of reported ADRs with public events, regulatory announcements, and with publications. Comparing the pharmacological, pharmacokinetic, and clinical ADR profiles of methylphenidate, aripiprazole, and risperidone, and of kinase drugs targeting the VEGF receptor, demonstrates how underlying molecular mechanisms can emerge from ADR co-analysis. The precautions and methods we describe may enable investigators to avoid confounding chemistry-based associations and reporting biases in FAERS, and illustrate how comparative analysis of ADRs can reveal underlying mechanisms.
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Fact vs fiction--how paratextual information shapes our reading processes.
Altmann, Ulrike; Bohrn, Isabel C; Lubrich, Oliver; Menninghaus, Winfried; Jacobs, Arthur M
2014-01-01
Our life is full of stories: some of them depict real-life events and were reported, e.g. in the daily news or in autobiographies, whereas other stories, as often presented to us in movies and novels, are fictional. However, we have only little insights in the neurocognitive processes underlying the reading of factual as compared to fictional contents. We investigated the neurocognitive effects of reading short narratives, labeled to be either factual or fictional. Reading in a factual mode engaged an activation pattern suggesting an action-based reconstruction of the events depicted in a story. This process seems to be past-oriented and leads to shorter reaction times at the behavioral level. In contrast, the brain activation patterns corresponding to reading fiction seem to reflect a constructive simulation of what might have happened. This is in line with studies on imagination of possible past or future events.
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Fact vs fiction—how paratextual information shapes our reading processes
Altmann, Ulrike; Bohrn, Isabel C.; Lubrich, Oliver; Menninghaus, Winfried; Jacobs, Arthur M.
2014-01-01
Our life is full of stories: some of them depict real-life events and were reported, e.g. in the daily news or in autobiographies, whereas other stories, as often presented to us in movies and novels, are fictional. However, we have only little insights in the neurocognitive processes underlying the reading of factual as compared to fictional contents. We investigated the neurocognitive effects of reading short narratives, labeled to be either factual or fictional. Reading in a factual mode engaged an activation pattern suggesting an action-based reconstruction of the events depicted in a story. This process seems to be past-oriented and leads to shorter reaction times at the behavioral level. In contrast, the brain activation patterns corresponding to reading fiction seem to reflect a constructive simulation of what might have happened. This is in line with studies on imagination of possible past or future events. PMID:22956671
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Watanabe, N; Sakakibara, J; Hovanessian, A G; Taniguchi, T; Fujita, T
1991-01-01
Expression of the Type I IFN (i.e., IFN-alpha s and IFN-beta) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive regulatory elements located in the human IFN-beta gene promoter: (1) the repeated elements which bind both the transcriptional activator IRF-1 and the repressor IRF-2 (IRF-elements; IRF-Es), and (2) the kappa B element (kappa B-E), which binds NF kappa B and is located between the IRF-Es and the TATA box. In this study we demonstrate that a promoter containing synthetic IRF-E, which displays high affinity for the IRFs can be efficiently activated by Newcastle disease virus (NDV). In contrast, such activation was either very weak or nil when cells were treated by IFN-beta or tumor necrosis factor-alpha (TNF-alpha), despite the fact they both efficiently induce de novo synthesis of the short-lived IRF-1 in L929 cells. In fact, efficient activation of the IRF-E apparently requires an event in addition to de novo IRF-1 induction, which can be elicited by NDV even in the presence of protein synthesis inhibitor, cycloheximide. Moreover, efficient activation of the IRF-E by NDV is specifically inhibited by the protein kinase inhibitor, Staurosporin. Hence our results suggest the importance of IRF-1 synthesis and post-translational modification event(s), possibly phosphorylation for the efficient activation of IRF-Es, which are otherwise under negative regulation by IRF-2. Images PMID:1886766
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Use of an Adverse Outcome Pathway for Hepatic Steatosis to Build Chemical Groups
The Adverse Outcome Pathway (AOP) framework systematically documents the mechanisms underlying effects of chemicals starting with the initial interaction of chemicals with the biological system, i.e. the molecular initiating event (MIE). Chemical activity in assays designed to mo...
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Single molecule thermodynamics in biological motors.
Taniguchi, Yuichi; Karagiannis, Peter; Nishiyama, Masayoshi; Ishii, Yoshiharu; Yanagida, Toshio
2007-04-01
Biological molecular machines use thermal activation energy to carry out various functions. The process of thermal activation has the stochastic nature of output events that can be described according to the laws of thermodynamics. Recently developed single molecule detection techniques have allowed each distinct enzymatic event of single biological machines to be characterized providing clues to the underlying thermodynamics. In this study, the thermodynamic properties in the stepping movement of a biological molecular motor have been examined. A single molecule detection technique was used to measure the stepping movements at various loads and temperatures and a range of thermodynamic parameters associated with the production of each forward and backward step including free energy, enthalpy, entropy and characteristic distance were obtained. The results show that an asymmetry in entropy is a primary factor that controls the direction in which the motor will step. The investigation on single molecule thermodynamics has the potential to reveal dynamic properties underlying the mechanisms of how biological molecular machines work.
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Empirical study of a unidirectional dense crowd during a real mass event
NASA Astrophysics Data System (ADS)
Zhang, X. L.; Weng, W. G.; Yuan, H. Y.; Chen, J. G.
2013-06-01
Many tragic crowd disasters have happened across the world in recent years, such as the Phnom Penh stampede in Cambodia, crowd disaster in Mina/Makkah, and the Love Parade disaster in Germany, showing that management of mass events is a tough task for organizers. The study of unidirectional flow, one of the most common forms of motion in mass activities, is essential for safe organization of such events. In this paper, the properties of unidirectional flow in a crowded street during a real mass event in China are quantitatively investigated with sophisticated active infrared counters and an image processing method. A complete dataset of flow rates during the whole celebration is recorded, and a time series analysis gives new insight into such activities. The spatial analysis shows that the velocity and density of the crowd are inhomogeneous due to the boundary effect, whereas the flux is uniform. The estimated capacity of the street indicates that the maximum flow rate under normal condition should be between 1.73 and 1.98 /m/s, which is in good agreement with several field studies available in the existing literature. In consideration of the significant deviation among different studies, fundamental diagrams of dense crowds are also re-verified, and the results here are consistent with those from other field studies of unidirectional flow, but different from the bidirectional and experimental results. It is suggested that the data from multidirectional flow and experiments cannot be directly applied to unidirectional dense flow in a real mass event. The results also imply that the density of a similar unidirectional marching crowd should be controlled to be under 5 /m2, which can produce optimal efficiency and have more possibility to ensure safety. The field study data given here provide a good example of a database for crowd studies.
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Misquitta-Ali, Christine M.; Cheng, Edith; O'Hanlon, Dave; Liu, Ni; McGlade, C. Jane; Tsao, Ming Sound; Blencowe, Benjamin J.
2011-01-01
Alternative splicing (AS) is a widespread mechanism underlying the generation of proteomic and regulatory complexity. However, which of the myriad of human AS events play important roles in disease is largely unknown. To identify frequently occurring AS events in lung cancer, we used AS microarray profiling and reverse transcription-PCR (RT-PCR) assays to survey patient-matched normal and adenocarcinoma tumor tissues from the lungs of 29 individuals diagnosed with non-small cell lung cancer (NSCLC). Of 5,183 profiled alternative exons, four displayed tumor-associated changes in the majority of the patients. These events affected transcripts from the VEGFA, MACF1, APP, and NUMB genes. Similar AS changes were detected in NUMB and APP transcripts in primary breast and colon tumors. Tumor-associated increases in NUMB exon 9 inclusion correlated with reduced levels of NUMB protein expression and activation of the Notch signaling pathway, an event that has been linked to tumorigenesis. Moreover, short hairpin RNA (shRNA) knockdown of NUMB followed by isoform-specific rescue revealed that expression of the exon 9-skipped (nontumor) isoform represses Notch target gene activation whereas expression of the exon 9-included (tumor) isoform lacks this activity and is capable of promoting cell proliferation. The results thus reveal widespread AS changes in NSCLC that impact cell signaling in a manner that likely contributes to tumorigenesis. PMID:21041478
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Misquitta-Ali, Christine M; Cheng, Edith; O'Hanlon, Dave; Liu, Ni; McGlade, C Jane; Tsao, Ming Sound; Blencowe, Benjamin J
2011-01-01
Alternative splicing (AS) is a widespread mechanism underlying the generation of proteomic and regulatory complexity. However, which of the myriad of human AS events play important roles in disease is largely unknown. To identify frequently occurring AS events in lung cancer, we used AS microarray profiling and reverse transcription-PCR (RT-PCR) assays to survey patient-matched normal and adenocarcinoma tumor tissues from the lungs of 29 individuals diagnosed with non-small cell lung cancer (NSCLC). Of 5,183 profiled alternative exons, four displayed tumor-associated changes in the majority of the patients. These events affected transcripts from the VEGFA, MACF1, APP, and NUMB genes. Similar AS changes were detected in NUMB and APP transcripts in primary breast and colon tumors. Tumor-associated increases in NUMB exon 9 inclusion correlated with reduced levels of NUMB protein expression and activation of the Notch signaling pathway, an event that has been linked to tumorigenesis. Moreover, short hairpin RNA (shRNA) knockdown of NUMB followed by isoform-specific rescue revealed that expression of the exon 9-skipped (nontumor) isoform represses Notch target gene activation whereas expression of the exon 9-included (tumor) isoform lacks this activity and is capable of promoting cell proliferation. The results thus reveal widespread AS changes in NSCLC that impact cell signaling in a manner that likely contributes to tumorigenesis.
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From slow to fast rupture during laboratory earthquakes in dolostones
NASA Astrophysics Data System (ADS)
Passelegue, F. X.; Fondriest, M.; Nicolas, A.; Aubry, J.; Schubnel, A.; Di Toro, G.
2016-12-01
Dolostones are the dominant lithology of the shallow portions of many seismically active regions (e.g., Italian Apennines). Displacement in natural fault zones cutting dolostones and exhumed from < 3-4 km depth is frequently localized on highly reflective (mirror-like) slip surfaces, coated with thin films of nano-granular fault rock. Using saw-cut dolostone samples, we conducted stick-slip experiments under upper crustal stress conditions (confining pressures and temperatures of 30, 60 and 90 MPa at 30, 65 and 100 °C, respectively). Samples were equipped with 15 piezoelectric transducers allowing the record of acoustic activity. At 30 and 65 °C, only slow ruptures (Vr < 200 m/s) were observed and the experimental faults exhibited ductile behaviour. At 65 °C, a slip strengthening behaviour was observed after the main slow rupture, leading to a succession of slow ruptures. At T = 100 °C and 30 MPa confining pressure, fault strengthening increased after each rupture, allowing, while the rupture processes remained slow (no acoustic activity), a sequence of slow stick-slip events. Instead, at the same ambient temperature but under larger confining pressures (60 and 90 MPa), we observed the transition from slow to fast rupture events (up to supershear rupture velocities), associated to clusters of acoustic activity and dynamic stress drop occurring in few tens of microseconds. In all experiments, mirror-like surfaces and nanoparticles were observed under the scanning electron microscope as a result of slow and fast ruptures. Clearly, mirror-like surfaces and nano powders are not representative of seismic slip events in cohesive dolostones. Instead, the transition from slow to fast ruptures (and generation of acoustic emissions) was related to a flash weakening processes, enhanced at 100° C, which allowed the experimental fault to weaken with slip faster than the rate at which the elastic strain was released from the surrounding medium.
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Vohra, Sunita; Cvijovic, Kosta; Boon, Heather; Foster, Brian C.; Jaeger, Walter; LeGatt, Don; Cembrowski, George; Murty, Mano; Tsuyuki, Ross T.; Barnes, Joanne; Charrois, Theresa L.; Arnason, John T.; Necyk, Candace; Ware, Mark; Rosychuk, Rhonda J.
2012-01-01
Background Many consumers use natural health products (NHPs) concurrently with prescription medications. As NHP-related harms are under-reported through passive surveillance, the safety of concurrent NHP-drug use remains unknown. To conduct active surveillance in participating community pharmacies to identify adverse events related to concurrent NHP-prescription drug use. Methodology/Principal Findings Participating pharmacists asked individuals collecting prescription medications about (i) concurrent NHP/drug use in the previous three months and (ii) experiences of adverse events. If an adverse event was identified and if the patient provided written consent, a research pharmacist conducted a guided telephone interview to gather additional information after obtaining additional verbal consent and documenting so within the interview form. Over a total of 112 pharmacy weeks, 2615 patients were screened, of which 1037 (39.7%; 95% CI: 37.8% to 41.5%) reported concurrent NHP and prescription medication use. A total of 77 patients reported a possible AE (2.94%; 95% CI: 2.4% to 3.7%), which represents 7.4% of those using NHPs and prescription medications concurrently (95%CI: 6.0% to 9.2%). Of 15 patients available for an interview, 4 (26.7%: 95% CI: 4.3% to 49.0%) reported an AE that was determined to be “probably” due to NHP use. Conclusions/Significance Active surveillance markedly improves identification and reporting of adverse events associated with concurrent NHP-drug use. Although not without challenges, active surveillance is feasible and can generate adverse event data of sufficient quality to allow for meaningful adjudication to assess potential harms. PMID:23028841
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Yu, Haihong; Dan, MengHan; Ma, Qingguo; Jin, Jia
2018-05-14
As herding is a typical characteristic of human behavior, many researchers have found the existence of herding behavior in online peer-to-peer lending through empirical surveys. However, the underlying neural basis of this phenomenon is still unclear. In the current study, we studied the neural activities of herding at decision-making stage and feedback stage using event-related potentials (ERPs). Our results showed that at decision-making stage, larger error related negativity (ERN) amplitude was induced under low-proportion conditions than that of high-proportion conditions. Meanwhile, during feedback stage, negative feedback elicited larger feedback related negativity (FRN) amplitude than that of positive feedback under low-proportion conditions, however, there was no significant FRN difference under high-proportion conditions. The current study suggests that herding behavior in online peer-to-peer lending is related to individual's risk perception and is possible to avoid negative emotions brought by failed investments. Copyright © 2018 Elsevier B.V. All rights reserved.
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NASA Astrophysics Data System (ADS)
Faria, B. V.; Day, S.; Fonseca, J. F.
2013-12-01
Three oceanic volcano islands in the west of the Cape Verde archipelago are considered to have the highest levels of volcanic hazard in the archipelago: Fogo, Brava, and Santo Antao. Fogo has had frequent mainly effusive eruptions in historic time, the most recent in 1995, whilst Brava and Santo Antao have ongoing geothermal activity and felt earthquakes, and have experienced geologically recent violent explosive eruptions. Therefore, these three islands have been the focus of recent efforts to set up seismic networks to monitor their activity. Here we present the first results from these networks, and propose interpretations of the monitored seismic activity in terms of subsurface volcano structures, near-surface intrusive activity and seasonal controls on geothermal activity. In Fogo, most recorded seismic events are hydrothermal events. These show a strong seasonal variation, increasing during the summer rain season and decreasing afterwards. Rare volcano-tectonic (VT) events (0.1
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Cell cycle gene expression under clinorotation
NASA Astrophysics Data System (ADS)
Artemenko, Olga
2016-07-01
Cyclins and cyclin-dependent kinase (CDK) are main regulators of the cell cycle of eukaryotes. It's assumes a significant change of their level in cells under microgravity conditions and by other physical factors actions. The clinorotation use enables to determine the influence of gravity on simulated events in the cell during the cell cycle - exit from the state of quiet stage and promotion presynthetic phase (G1) and DNA synthesis phase (S) of the cell cycle. For the clinorotation effect study on cell proliferation activity is the necessary studies of molecular mechanisms of cell cycle regulation and development of plants under altered gravity condition. The activity of cyclin D, which is responsible for the events of the cell cycle in presynthetic phase can be controlled by the action of endogenous as well as exogenous factors, but clinorotation is one of the factors that influence on genes expression that regulate the cell cycle.These data can be used as a model for further research of cyclin - CDK complex for study of molecular mechanisms regulation of growth and proliferation. In this investigation we tried to summarize and analyze known literature and own data we obtained relatively the main regulators of the cell cycle in altered gravity condition.
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Time distributions of solar energetic particle events: Are SEPEs really random?
NASA Astrophysics Data System (ADS)
Jiggens, P. T. A.; Gabriel, S. B.
2009-10-01
Solar energetic particle events (SEPEs) can exhibit flux increases of several orders of magnitude over background levels and have always been considered to be random in nature in statistical models with no dependence of any one event on the occurrence of previous events. We examine whether this assumption of randomness in time is correct. Engineering modeling of SEPEs is important to enable reliable and efficient design of both Earth-orbiting and interplanetary spacecraft and future manned missions to Mars and the Moon. All existing engineering models assume that the frequency of SEPEs follows a Poisson process. We present analysis of the event waiting times using alternative distributions described by Lévy and time-dependent Poisson processes and compared these with the usual Poisson distribution. The results show significant deviation from a Poisson process and indicate that the underlying physical processes might be more closely related to a Lévy-type process, suggesting that there is some inherent “memory” in the system. Inherent Poisson assumptions of stationarity and event independence are investigated, and it appears that they do not hold and can be dependent upon the event definition used. SEPEs appear to have some memory indicating that events are not completely random with activity levels varying even during solar active periods and are characterized by clusters of events. This could have significant ramifications for engineering models of the SEP environment, and it is recommended that current statistical engineering models of the SEP environment should be modified to incorporate long-term event dependency and short-term system memory.
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NASA Technical Reports Server (NTRS)
Wallington, Clint
1999-01-01
Educational outreach is an integral part of the International Space Station (ISS) mandate. In a few scant years, the International Space Station has already established a tradition of successful, general outreach activities. However, as the number of outreach events increased and began to reach school classrooms, those events came under greater scrutiny by the education community. Some of the ISS electronic field trips, while informative and helpful, did not meet the generally accepted criteria for education events, especially within the context of the classroom. To make classroom outreach events more acceptable to educators, the ISS outreach program must differentiate between communication events (meant to disseminate information to the general public) and education events (designed to facilitate student learning). In contrast to communication events, education events: are directed toward a relatively homogeneous audience who are gathered together for the purpose of learning, have specific performance objectives which the students are expected to master, include a method of assessing student performance, and include a series of structured activities that will help the students to master the desired skill(s). The core of the ISS education events is an interactive videoconference between students and ISS representatives. This interactive videoconference is to be preceded by and followed by classroom activities which help the students aftain the specified learning objectives. Using the interactive videoconference as the centerpiece of the education event lends a special excitement and allows students to ask questions about what they are learning and about the International Space Station and NASA. Whenever possible, the ISS outreach education events should be congruent with national guidelines for student achievement. ISS outreach staff should recognize that there are a number of different groups that will review the events, and that each group has different criteria for acceptance. For example, school administrators are more likely to be concerned about an event meeting national standards and the cost of the event. In contrast, a teacher's acceptance of an education event may be directly related to the amount of extra work the event imposes upon that teacher. ISS education events must be marketed differently to the different groups of educators, and must never increase the workload of the average teacher.
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Synchrony and Desynchrony in Circadian Clocks: Impacts on Learning and Memory
ERIC Educational Resources Information Center
Krishnan, Harini C.; Lyons, Lisa C.
2015-01-01
Circadian clocks evolved under conditions of environmental variation, primarily alternating light dark cycles, to enable organisms to anticipate daily environmental events and coordinate metabolic, physiological, and behavioral activities. However, modern lifestyle and advances in technology have increased the percentage of individuals working in…
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Projected increase in El Niño-driven tropical cyclone frequency in the Pacific
NASA Astrophysics Data System (ADS)
Chand, Savin S.; Tory, Kevin J.; Ye, Hua; Walsh, Kevin J. E.
2017-02-01
The El Niño/Southern Oscillation (ENSO) drives substantial variability in tropical cyclone (TC) activity around the world. However, it remains uncertain how the projected future changes in ENSO under greenhouse warming will affect TC activity, apart from an expectation that the overall frequency of TCs is likely to decrease for most ocean basins. Here we show robust changes in ENSO-driven variability in TC occurrence by the late twenty-first century. In particular, we show that TCs become more frequent (~20-40%) during future-climate El Niño events compared with present-climate El Niño events--and less frequent during future-climate La Niña events--around a group of small island nations (for example, Fiji, Vanuatu, Marshall Islands and Hawaii) in the Pacific. We examine TCs across 20 models from the Coupled Model Intercomparison Project phase 5 database, forced under historical and greenhouse warming conditions. The 12 most realistic models identified show a strong consensus on El Niño-driven changes in future-climate large-scale environmental conditions that modulate development of TCs over the off-equatorial western Pacific and the central North Pacific regions. These results have important implications for climate change and adaptation pathways for the vulnerable Pacific island nations.
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Martins, Marina Angela; Silva, Maria Luiza; Elói-Santos, Silvana Maria; Ribeiro, José Geraldo Leite; Peruhype-Magalhães, Vanessa; Marciano, Ana Paula Vieira; Homma, Akira; Kroon, Erna Geessien; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis
2008-02-26
Detailed multiparametric phenotypic investigation aiming to characterize the kinetics of the innate immune response in the peripheral blood following 17DD yellow fever (17DD-YF) first-time vaccination was performed. Results showed increased frequency of monocytes and NK cell subpopulations besides unexpected up-regulation of granulocytes activation status (CD28+/CD23+ and CD28+/HLA-DR+, respectively). Up-regulation of Fcgamma-R and IL-10-R expression emerge as putative events underlying the mixed pattern of phenotypic features triggered by the 17DD yellow fever (17DD-YF) vaccination. Mixed pattern of chemokine receptors expression further support our hypothesis that a parallel establishment of activation/modulation microenvironment plays a pivotal role in the protective immunity triggered by the 17DD-YF vaccine.
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Baxi, Shrujal; Yang, Annie; Gennarelli, Renee L; Khan, Niloufer; Wang, Ziwei; Boyce, Lindsay; Korenstein, Deborah
2018-03-14
To evaluate rates of serious organ specific immune-related adverse events, general adverse events related to immune activation, and adverse events consistent with musculoskeletal problems for anti-programmed cell death 1 (PD-1) drugs overall and compared with control treatments. Systematic review and meta-analysis. Medline, Embase, Cochrane Library, Web of Science, and Scopus searched to 16 March 2017 and combined with data from ClinicalTrials.gov. Eligible studies included primary clinical trial data on patients with cancer with recurrent or metastatic disease. Three independent investigators extracted data on adverse events from ClinicalTrials.gov and the published studies. Risk of bias was assessed using the Cochrane tool by three independent investigators. 13 relevant studies were included; adverse event data were available on ClinicalTrials.gov for eight. Studies compared nivolumab (n=6), pembrolizumab (5), or atezolizumab (2) with chemotherapy (11), targeted drugs (1), or both (1). Serious organ specific immune-related adverse events were rare, but compared with standard treatment, rates of hypothyroidism (odds ratio 7.56, 95% confidence interval 4.53 to 12.61), pneumonitis (5.37, 2.73 to 10.56), colitis (2.88, 1.30 to 6.37), and hypophysitis (3.38, 1.02 to 11.08) were increased with anti-PD-1 drugs. Of the general adverse events related to immune activation, only the rate of rash (2.34, 2.73 to 10.56) increased. Incidence of fatigue (32%) and diarrhea (19%) were high but similar to control. Reporting of adverse events consistent with musculoskeletal problems was inconsistent; rates varied but were over 20% in some studies for arthraligia and back pain. Organ specific immune-related adverse events are uncommon with anti-PD-1 drugs but the risk is increased compared with control treatments. General adverse events related to immune activation are largely similar. Adverse events consistent with musculoskeletal problems are inconsistently reported but adverse events may be common. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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Dancing red sprites and the lightning activity in their parent thunderstorm
NASA Astrophysics Data System (ADS)
Bór, József; Zelkó, Zoltán; Hegedüs, Tibor; Jäger, Zoltán; Mlynarczyk, Janusz; Popek, Martin; Betz, Hans-Dieter
2016-04-01
Red sprites are brief optical emissions initiated in the mesosphere by intense tropospheric lightning discharges. A group of red sprites, in which the elements appear in rapid succession with some lateral offset from one another is referred to as a dancing sprite event. The occurrence of such events implies that significant and sequential charge removal extending to large regions of the thunderstorm can take place in the underlying cloud system. In this work, we examine the relation of the locations and observation times of appearing sprite elements to the temporal and spatial distribution of the lightning activity in a specific sprite-active thunderstorm. The selected mesoscale convective system (MCS) composed of several extremely active thundercloud cells crossed Central Europe from South-West to North-East through Germany, Austria, the Czech Republic, and Poland on the night of 6 August, 2013. This MCS has triggered over one hundred sprites including several dancing sprite events. Video recordings of sprites captured from Sopron, Hungary (16.6°E, 47.7°N) and Nydek, Czech Republic (18.8°E, 49.7°N) were used to identify dancing sprite events and to determine the exact locations of the appearing sprite elements by a triangulation technique used originally to analyze meteor observations. Lightning activity in the MCS can be reviewed using the database of LINET lightning detection network which fully covers the region of interest (ROI). The poster demonstrates how cases of sequential charge removal in the thunderstorm can be followed by combining the available information on the occurrence time, location, polarity, and type (CG/IC) of detected lightning strokes in the ROI on one hand and the occurrence time and location of elements in dancing sprite events on the other hand.
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United States Air Force Statistical Digest, Fiscal Year 1965, Twentieth Edition
1965-09-30
prOVided by the USAF under Military Assistance Program . MAP EMPLOYEES - Category of civilian personnel engaged in activities reqUired in carrying out the...92 - USAF CIVIUAN EMPLOYEES IN SALARIED AND WAGE BOARD GROUPS EMPLOYED UNDER MILITARY ASSISTANCE PROGRAM (MAP), WORLO-WIDE, AT END OF QUARTER - FY...statistical material for tary Assistance Program (MAP), and re- the digest. AFCHO will furnish a chronology lated studies and historical events. of
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Activity statistics in a colloidal glass former: Experimental evidence for a dynamical transition
NASA Astrophysics Data System (ADS)
Abou, Bérengère; Colin, Rémy; Lecomte, Vivien; Pitard, Estelle; van Wijland, Frédéric
2018-04-01
In a dense colloidal suspension at a volume fraction below the glass transition, we follow the trajectories of an assembly of tracers over a large time window. We define a local activity, which quantifies the local tendency of the system to rearrange. We determine the statistics of the time integrated activity, and we argue that it develops a low activity tail that comes together with the onset of glassy-like behavior and heterogeneous dynamics. These rare events may be interpreted as the reflection of an underlying dynamic phase transition.
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Strain-dependent activation energy of shear transformation in metallic glasses
NASA Astrophysics Data System (ADS)
Xu, Bin; Falk, Michael; Li, Jinfu; Kong, Lingti
2017-04-01
Shear transformation (ST) plays a decisive role in determining the mechanical behavior of metallic glasses, which is believed to be a stress-assisted thermally activated process. Understanding the dependence in its activation energy on the stress imposed on the material is of central importance to model the deformation process of metallic glasses and other amorphous solids. Here a theoretical model is proposed to predict the variation of the minimum energy path (MEP) associated with a particular ST event upon further deformation. Verification based on atomistic simulations and calculations are also conducted. The proposed model reproduces the MEP and activation energy of an ST event under different imposed macroscopic strains based on a known MEP at a reference strain. Moreover, an analytical approach is proposed based on the atomistic calculations, which works well when the stress varies linearity along the MEP. These findings provide necessary background for understanding the activation processes and, in turn, the mechanical behavior of metallic glasses.
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Optimal weighted averaging of event related activity from acquisitions with artifacts.
Vollero, Luca; Petrichella, Sara; Innello, Giulio
2016-08-01
In several biomedical applications that require the signal processing of biological data, the starting procedure for noise reduction is the ensemble averaging of multiple repeated acquisitions (trials). This method is based on the assumption that each trial is composed of two additive components: (i) a time-locked activity related to some sensitive/stimulation phenomenon (ERA, Event Related Activity in the following) and (ii) a sum of several other non time-locked background activities. The averaging aims at estimating the ERA activity under very low Signal to Noise and Interference Ratio (SNIR). Although averaging is a well established tool, its performance can be improved in the presence of high-power disturbances (artifacts) by a trials classification and removal stage. In this paper we propose, model and evaluate a new approach that avoids trials removal, managing trials classified as artifact-free and artifact-prone with two different weights. Based on the model, a weights tuning is possible and through modeling and simulations we show that, when optimally configured, the proposed solution outperforms classical approaches.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Aad, G.
2016-03-02
The relationship between jet production in the central region and the underlying-event activity in a pseudorapidity-separated region is studied in 4.0 pb -1 of √s = 2.76 TeV pp collision data recorded with the ATLAS detector at the LHC. The underlying event is characterised through measurements of the average value of the sum of the transverse energy at large pseudorapidity downstream of one of the protons, which are reported here as a function of hard-scattering kinematic variables. The hard scattering is characterised by the average transverse momentum and pseudorapidity of the two highest transverse momentum jets in the event. Themore » dijet kinematics are used to estimate, on an event-by-event basis, the scaled longitudinal momenta of the hard-scattered partons in the target and projectile beam-protons moving toward and away from the region measuring transverse energy, respectively. Transverse energy production at large pseudorapidity is observed to decrease with a linear dependence on the longitudinal momentum fraction in the target proton and to depend only weakly on that in the projectile proton. Lastly, the results are compared to the predictions of various Monte Carlo event generators, which qualitatively reproduce the trends observed in data but generally underpredict the overall level of transverse energy at forward pseudorapidity.« less
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Laszlo, Sarah; Stites, Mallory; Federmeier, Kara D
2012-01-01
A growing body of evidence suggests that semantic access is obligatory. Several studies have demonstrated that brain activity associated with semantic processing, measured in the N400 component of the event-related brain potential (ERP), is elicited even by meaningless, orthographically illegal strings, suggesting that semantic access is not gated by lexicality. However, the downstream consequences of that activity vary by item type, exemplified by the typical finding that N400 activity is reduced by repetition for words and pronounceable nonwords but not for illegal strings. We propose that this lack of repetition effect for illegal strings is caused not by lack of contact with semantics, but by the unrefined nature of that contact under conditions in which illegal strings can be readily categorised as task-irrelevant. To test this, we collected ERPs from participants performing a modified Lexical Decision Task, in which the presence of orthographically illegal acronyms rendered meaningless illegal strings more difficult lures than normal. Confirming our hypothesis, under these conditions illegal strings elicited robust N400 repetition effects, quantitatively and qualitatively similar to those elicited by words, pseudowords, and acronyms.
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Analysis of strong scintillation events by using GPS data at low latitudes
NASA Astrophysics Data System (ADS)
Forte, Biagio; Jakowski, Norbert; Wilken, Volker
2010-05-01
Drifting structures charaterised by inhomogeneities in the spatial electron density distribution at ionospheric heights originate scintillation of radio waves propagating through. The fractional electron density fluctuations and the corresponding scintillation levels may reach extreme values at low latitudes during high solar activity. Strong scintillation events have disruptive effects on a number of technological applications. In particular, operations and services based on GPS signals and receivers may experience severe disruption due to a significant degradation of the signal-to-noise ratio, eventually leading to signal loss of lock. Experimental scintillation data collected in the Asian sector at low latitudes by means of a GPS dual frequency receiver under moderate solar activity (2006) have been analysed. The GPS receiver is particularly modified in firmware in order to record power estimates on the C/A code as well as on the carriers L1 and L2. Strong scintillation activity is recorded in the post-sunset period (saturating S4 and SI as high as 20 dB). An overview of these events is presented, by taking into account scintillation impact on the signal intensity, phase, and dynamics. In particular, the interpretation of these events based on a refined scattering theory is provided with possible consequences for standard scintillation models.
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Ecological Responses to Extreme Flooding Events: A Case Study with a Reintroduced Bird
Soriano-Redondo, Andrea; Bearhop, Stuart; Cleasby, Ian R.; Lock, Leigh; Votier, Stephen C.; Hilton, Geoff M.
2016-01-01
In recent years numerous studies have documented the effects of a changing climate on the world’s biodiversity. Although extreme weather events are predicted to increase in frequency and intensity and are challenging to organisms, there are few quantitative observations on the survival, behaviour and energy expenditure of animals during such events. We provide the first data on activity and energy expenditure of birds, Eurasian cranes Grus grus, during the winter of 2013–14, which saw the most severe floods in SW England in over 200 years. We fitted 23 cranes with telemetry devices and used remote sensing data to model flood dynamics during three consecutive winters (2012–2015). Our results show that during the acute phase of the 2013–14 floods, potential feeding areas decreased dramatically and cranes restricted their activity to a small partially unflooded area. They also increased energy expenditure (+15%) as they increased their foraging activity and reduced resting time. Survival did not decline in 2013–14, indicating that even though extreme climatic events strongly affected time-energy budgets, behavioural plasticity alleviated any potential impact on fitness. However under climate change scenarios such challenges may not be sustainable over longer periods and potentially could increase species vulnerability. PMID:27345214
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Uono, Shota; Sato, Wataru; Sawada, Reiko; Kochiyama, Takanori; Toichi, Motomi
2018-05-04
Eye gaze triggers attentional shifts with and without conscious awareness. It remains unclear whether the spatiotemporal patterns of electric neural activity are the same for conscious and unconscious attentional shifts. Thus, the present study recorded event-related potentials (ERPs) and evaluated the neural activation involved in attentional orienting induced by subliminal and supraliminal gaze cues. Nonpredictive gaze cues were presented in the central field of vision, and participants were asked to detect a subsequent peripheral target. The mean reaction time was shorter for congruent gaze cues than for incongruent gaze cues under both presentation conditions, indicating that both types of cues reliably trigger attentional orienting. The ERP analysis revealed that averted versus straight gaze induced greater negative deflection in the bilateral fronto-central and temporal regions between 278 and 344 ms under both supraliminal and subliminal presentation conditions. Supraliminal cues, irrespective of gaze direction, induced a greater negative amplitude than did subliminal cues at the right posterior cortices at a peak of approximately 170 ms and in the 200-300 ms. These results suggest that similar spatial and temporal fronto-parietal activity is involved in attentional orienting triggered by both supraliminal and subliminal gaze cues, although inputs from different visual processing routes (cortical and subcortical regions) may trigger activity in the attentional network. Copyright © 2018 Elsevier B.V. All rights reserved.
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Jonkman, L M; Kenemans, J L; Kemner, C; Verbaten, M N; van Engeland, H
2004-07-01
This study was aimed at investigating whether attention-deficit hyperactivity disorder (ADHD) children suffer from specific early selective attention deficits in the visual modality with the aid of event-related brain potentials (ERPs). Furthermore, brain source localization was applied to identify brain areas underlying possible deficits in selective visual processing in ADHD children. A two-channel visual color selection task was administered to 18 ADHD and 18 control subjects in the age range of 7-13 years and ERP activity was derived from 30 electrodes. ADHD children exhibited lower perceptual sensitivity scores resulting in poorer target selection. The ERP data suggested an early selective-attention deficit as manifested in smaller frontal positive activity (frontal selection positivity; FSP) in ADHD children around 200 ms whereas later occipital and fronto-central negative activity (OSN and N2b; 200-400 ms latency) appeared to be unaffected. Source localization explained the FSP by posterior-medial equivalent dipoles in control subjects, which may reflect the contribution of numerous surrounding areas. ADHD children have problems with selective visual processing that might be caused by a specific early filtering deficit (absent FSP) occurring around 200 ms. The neural sources underlying these problems have to be further identified. Source localization also suggested abnormalities in the 200-400 ms time range, pertaining to the distribution of attention-modulated activity in lateral frontal areas.
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Human-ignited wildfire patterns and responses to policy shifts
M. L. Chas-Amil; J. P. Prestemon; C. J. McClean; J. Touza
2015-01-01
Development of efficient forest wildfire policies requires an understanding of the underlying reasons behind forest fire occurrences. Globally, there is a close relationship between forest wildfires and human activities; most wildfires are human events due to negligence (e.g., agricultural burning escapes) and deliberate actions (e.g., vandalism, pyromania, revenge,...
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Environmental Scanning: Assessing Local Business Training Needs.
ERIC Educational Resources Information Center
Clagett, Craig A.; Huntington, Robin B.
Environmental scanning (ES) is a formal process of assessing trends and forecasting events which can influence an institution so that the potential challenges and opportunities can be effectively anticipated during strategic planning activities. The goal of ES is the implementation of proactive, anticipatory policies that will be robust under a…
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NASA Astrophysics Data System (ADS)
Blaen, Phillip; Khamis, Kieran; Lloyd, Charlotte; Krause, Stefan
2017-04-01
At the river catchment scale, storm events can drive highly variable behaviour in nutrient and water fluxes, yet short-term dynamics are frequently missed by low resolution sampling regimes. In addition, nutrient source contributions can vary significantly within and between storm events. Our inability to identify and characterise time dynamic source zone contributions severely hampers the adequate design of land use management practices in order to control nutrient exports from agricultural landscapes. Here, we utilise an 8-month high-frequency (hourly) time series of streamflow, nitrate concentration (NO3) and fluorescent dissolved organic matter concentration (FDOM) derived from optical in-situ sensors located in a headwater agricultural catchment. We characterised variability in flow and nutrient dynamics across 29 storm events. Storm events represented 31% of the time series and contributed disproportionately to nutrient loads (43% of NO3 and 36% of CDOM) relative to their duration. Principal components analysis of potential hydroclimatological controls on nutrient fluxes demonstrated that a small number of components, representing >90% of variance in the dataset, were highly significant model predictors of inter-event variability in catchment nutrient export. Hysteresis analysis of nutrient concentration-discharge relationships suggested spatially discrete source zones existed for NO3 and FDOM, and that activation of these zones varied on an event-specific basis. Our results highlight the benefits of high-frequency in-situ monitoring for characterising complex short-term nutrient dynamics and unravelling connections between hydroclimatological variability and river nutrient export and source zone activation under extreme flow conditions. These new process-based insights are fundamental to underpinning the development of targeted management measures to reduce nutrient loading of surface waters.
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NASA Astrophysics Data System (ADS)
Bachmann, C. E.; Lindsey, N.; Foxall, W.; Robertson, M.
2014-12-01
Earthquakes induced by human activity have become a matter of heightened public concern during recent years. Of particular concern is seismicity associated with wastewater injection, which has included events having magnitudes greater than 5. The causes of the induced events are primarily changes in pore-pressure, fluid volume and perhaps temperature due to injection. Recent research in the US has focused on mid-continental regions having low rates of naturally-occurring seismicity, where induced events can be identified by relatively straightforward spatial and temporal correlation of seismicity with high-volume injection activities. Recent examples include events correlated with injection of wastewater in Oklahoma, Arkansas, Texas and Ohio, and long-term brine injection in the Paradox Valley in Colorado. Even in some of the cases where there appears at first sight to be a clear spatial correlation between seismicity and injection, it has been difficult to establish causality definitively. Here, we discuss methods to identify induced seismicity in active tectonic regions. We concentrate our study on Southern California, where large numbers of wastewater injection wells are located in oil-producing basins that experience moderate to high rates of naturally-occurring seismicity. Using the catalog of high-precision CISN relocations produced by Hauksson et al. (BSSA, 2012), we aim to discriminate induced from natural events based on spatio-temporal patterns of seismicity occurrence characteristics and their relationships to injection activities, known active faults and other faults favorably oriented for slip under the tectonic stress field. Since the vast majority of induced earthquakes are very small, it is crucial to include all events above the detection threshold of the CISN in each area studied. In addition to exploring the correlation of seismicity to injection activities in time and space, we analyze variations in frequency-magnitude distributions, which can be related to differences between the physical conditions at the sources of fluid-induced and natural earthquakes. While induced seismicity often does not show different mechanisms than tectonic earthquakes, an abundance of induced microseismicity causes the slope of the frequency-magnitude distribution to increase locally.
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Evaluation of Music And Astronomy Under The Stars: Bringing Science To New Audiences At Music Events
NASA Astrophysics Data System (ADS)
Lubowich, D.; Torff, B.
2014-07-01
Evaluations were conducted of the 2009-2012 NASA-funded Music and Astronomy Under the Stars (MAUS) program at outdoor concerts (see the separate MAUS poster at this meeting). MAUS promoted lifelong learning by providing opportunities for the public to look through telescopes, participate in hands-on activities, and view posters, banners, and videos at events where large numbers of people are gathered. Surveys were given to 1.6% of the concertgoers at MAUS events with the participants expressing their level of agreement on a four-point scale with the following statements: “The astronomy at this event has been an enjoyable experience;” “It has been easy to comprehend the astronomy at this event;” “This event has helped me learn new things about astronomy;” “This event has made me want to learn more about astronomy;” and “This event has increased my interest in science.” On a scale where 1 = strongly disagree, 2 = disagree, 3 = agree, and 4 = strongly agree, MAUS received high ratings (>3.34/4) on all outcomes. MAUS successfully reached people at different concerts who had little interest in science. MAUS appealed to concert attendees of both genders, all ages, multiple levels of education, and all musical tastes. MAUS positively influenced the public's knowledge of and interest in astronomy. The high ratings from virtually all respondents indicate that the gains were not restricted to science enthusiasts. The data strongly supports the conclusion that MAUS—bringing astronomy to people at musical events—is effective!
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Shared memories reveal shared structure in neural activity across individuals
Chen, J.; Leong, Y.C.; Honey, C.J.; Yong, C.H.; Norman, K.A.; Hasson, U.
2016-01-01
Our lives revolve around sharing experiences and memories with others. When different people recount the same events, how similar are their underlying neural representations? Participants viewed a fifty-minute movie, then verbally described the events during functional MRI, producing unguided detailed descriptions lasting up to forty minutes. As each person spoke, event-specific spatial patterns were reinstated in default-network, medial-temporal, and high-level visual areas. Individual event patterns were both highly discriminable from one another and similar between people, suggesting consistent spatial organization. In many high-order areas, patterns were more similar between people recalling the same event than between recall and perception, indicating systematic reshaping of percept into memory. These results reveal the existence of a common spatial organization for memories in high-level cortical areas, where encoded information is largely abstracted beyond sensory constraints; and that neural patterns during perception are altered systematically across people into shared memory representations for real-life events. PMID:27918531
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Egbring, Marco; Far, Elmira; Roos, Malgorzata; Dietrich, Michael; Brauchbar, Mathis; Kullak-Ublick, Gerd A; Trojan, Andreas
2016-09-06
The well-being of breast cancer patients and reporting of adverse events require close monitoring. Mobile apps allow continuous recording of disease- and medication-related symptoms in patients undergoing chemotherapy. The aim of the study was to evaluate the effects of a mobile app on patient-reported daily functional activity in a supervised and unsupervised setting. We conducted a randomized controlled study of 139 breast cancer patients undergoing chemotherapy. Patient status was self-measured using Eastern Cooperative Oncology Group scoring and Common Terminology Criteria for Adverse Events. Participants were randomly assigned to a control group, an unsupervised group that used a mobile app to record data, or a supervised group that used the app and reviewed data with a physician. Primary outcome variables were change in daily functional activity and symptoms over three outpatient visits. Functional activity scores declined in all groups from the first to second visit. However, from the second to third visit, only the supervised group improved, whereas the others continued to decline. Overall, the supervised group showed no significant difference from the first (median 90.85, IQR 30.67) to third visit (median 84.76, IQR 18.29, P=.72). Both app-using groups reported more distinct adverse events in the app than in the questionnaire (supervised: n=1033 vs n=656; unsupervised: n=852 vs n=823), although the unsupervised group reported more symptoms overall (n=4808) in the app than the supervised group (n=4463). The mobile app was associated with stabilized daily functional activity when used under collaborative review. App-using participants could more frequently report adverse events, and those under supervision made fewer and more precise entries than unsupervised participants. Our findings suggest that patient well-being and awareness of chemotherapy adverse effects can be improved by using a mobile app in collaboration with the treating physician. ClinicalTrials.gov NCT02004496; https://clinicaltrials.gov/ct2/show/NCT02004496 (Archived by WebCite at http://www.webcitation.org/6k68FZHo2).
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Egbring, Marco; Far, Elmira; Roos, Malgorzata; Dietrich, Michael; Brauchbar, Mathis; Kullak-Ublick, Gerd A
2016-01-01
Background The well-being of breast cancer patients and reporting of adverse events require close monitoring. Mobile apps allow continuous recording of disease- and medication-related symptoms in patients undergoing chemotherapy. Objective The aim of the study was to evaluate the effects of a mobile app on patient-reported daily functional activity in a supervised and unsupervised setting. Methods We conducted a randomized controlled study of 139 breast cancer patients undergoing chemotherapy. Patient status was self-measured using Eastern Cooperative Oncology Group scoring and Common Terminology Criteria for Adverse Events. Participants were randomly assigned to a control group, an unsupervised group that used a mobile app to record data, or a supervised group that used the app and reviewed data with a physician. Primary outcome variables were change in daily functional activity and symptoms over three outpatient visits. Results Functional activity scores declined in all groups from the first to second visit. However, from the second to third visit, only the supervised group improved, whereas the others continued to decline. Overall, the supervised group showed no significant difference from the first (median 90.85, IQR 30.67) to third visit (median 84.76, IQR 18.29, P=.72). Both app-using groups reported more distinct adverse events in the app than in the questionnaire (supervised: n=1033 vs n=656; unsupervised: n=852 vs n=823), although the unsupervised group reported more symptoms overall (n=4808) in the app than the supervised group (n=4463). Conclusions The mobile app was associated with stabilized daily functional activity when used under collaborative review. App-using participants could more frequently report adverse events, and those under supervision made fewer and more precise entries than unsupervised participants. Our findings suggest that patient well-being and awareness of chemotherapy adverse effects can be improved by using a mobile app in collaboration with the treating physician. ClinicalTrial ClinicalTrials.gov NCT02004496; https://clinicaltrials.gov/ct2/show/NCT02004496 (Archived by WebCite at http://www.webcitation.org/6k68FZHo2) PMID:27601354
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Arzouan, Yossi; Solomon, Sorin; Faust, Miriam; Goldstein, Abraham
2011-04-27
Language comprehension is a complex task that involves a wide network of brain regions. We used topological measures to qualify and quantify the functional connectivity of the networks used under various comprehension conditions. To that aim we developed a technique to represent functional networks based on EEG recordings, taking advantage of their excellent time resolution in order to capture the fast processes that occur during language comprehension. Networks were created by searching for a specific causal relation between areas, the negative feedback loop, which is ubiquitous in many systems. This method is a simple way to construct directed graphs using event-related activity, which can then be analyzed topologically. Brain activity was recorded while subjects read expressions of various types and indicated whether they found them meaningful. Slightly different functional networks were obtained for event-related activity evoked by each expression type. The differences reflect the special contribution of specific regions in each condition and the balance of hemispheric activity involved in comprehending different types of expressions and are consistent with the literature in the field. Our results indicate that representing event-related brain activity as a network using a simple temporal relation, such as the negative feedback loop, to indicate directional connectivity is a viable option for investigation which also derives new information about aspects not reflected in the classical methods for investigating brain activity.
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Event generators for address event representation transmitters
NASA Astrophysics Data System (ADS)
Serrano-Gotarredona, Rafael; Serrano-Gotarredona, Teresa; Linares Barranco, Bernabe
2005-06-01
Address Event Representation (AER) is an emergent neuromorphic interchip communication protocol that allows for real-time virtual massive connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (with nano-seconds timings), synaptic neural connections can be time multiplexed, while neural activity signals (with mili-seconds timings) are sampled at low frequencies. Also, neurons generate 'events' according to their activity levels. More active neurons generate more events per unit time, and access the interchip communication channel more frequently, while neurons with low activity consume less communication bandwidth. In a typical AER transmitter chip, there is an array of neurons that generate events. They send events to a peripheral circuitry (let's call it "AER Generator") that transforms those events to neurons coordinates (addresses) which are put sequentially on an interchip high speed digital bus. This bus includes a parallel multi-bit address word plus a Rqst (request) and Ack (acknowledge) handshaking signals for asynchronous data exchange. There have been two main approaches published in the literature for implementing such "AER Generator" circuits. They differ on the way of handling event collisions coming from the array of neurons. One approach is based on detecting and discarding collisions, while the other incorporates arbitration for sequencing colliding events . The first approach is supposed to be simpler and faster, while the second is able to handle much higher event traffic. In this article we will concentrate on the second arbiter-based approach. Boahen has been publishing several techniques for implementing and improving the arbiter based approach. Originally, he proposed an arbitration squeme by rows, followed by a column arbitration. In this scheme, while one neuron was selected by the arbiters to transmit his event out of the chip, the rest of neurons in the array were freezed to transmit any further events during this time window. This limited the maximum transmission speed. In order to improve this speed, Boahen proposed an improved 'burst mode' scheme. In this scheme after the row arbitration, a complete row of events is pipelined out of the array and arbitered out of the chip at higher speed. During this single row event arbitration, the array is free to generate new events and communicate to the row arbiter, in a pipelined mode. This scheme significantly improves maximum event transmission speed, specially for high traffic situations were speed is more critical. We have analyzed and studied this approach and have detected some shortcomings in the circuits reported by Boahen, which may render some false situations under some statistical conditions. The present paper proposes some improvements to overcome such situations. The improved "AER Generator" has been implemented in an AER transmitter system
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Under-Body Blast Mitigation: Stand-Alone Seat Safety Activation System
2014-04-01
Restraints, Airbags or other protection systems) to mitigate injury to the occupant during the onset of the event. Injuries may occur as soon as 2.5 ms...cost-effective sensor to accurately and consistently deploy airbags and other pyrotechnic restraint systems based on accelerometers and other...Circuitry are critically important in order to activate the initiators of air bags and pyrotechnic restraint system such as airbags at the very first
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Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets
Maciejewski, Mateusz; Lounkine, Eugen; Whitebread, Steven; Farmer, Pierre; DuMouchel, William; Shoichet, Brian K; Urban, Laszlo
2017-01-01
The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and artefactual trends. To address these problems, we mapped drugs to their ingredients and used natural language processing to classify and correlate drug events. Our analysis exposed key idiosyncrasies in FAERS, for example reports of thalidomide causing a deadly ADR when used against myeloma, a likely result of the disease itself; multiplications of the same report, unjustifiably increasing its importance; correlation of reported ADRs with public events, regulatory announcements, and with publications. Comparing the pharmacological, pharmacokinetic, and clinical ADR profiles of methylphenidate, aripiprazole, and risperidone, and of kinase drugs targeting the VEGF receptor, demonstrates how underlying molecular mechanisms can emerge from ADR co-analysis. The precautions and methods we describe may enable investigators to avoid confounding chemistry-based associations and reporting biases in FAERS, and illustrate how comparative analysis of ADRs can reveal underlying mechanisms. DOI: http://dx.doi.org/10.7554/eLife.25818.001 PMID:28786378
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Shelly, D.R.; Hill, D.P.
2011-01-01
Brittle-failure earthquakes in the lower crust, where high pressures and temperatures would typically promote ductile deformation, are relatively rare but occasionally observed beneath active volcanic centers. Where they occur, these earthquakes provide a rare opportunity to observe volcanic processes in the lower crust, such as fluid injection and migration, which may induce brittle faulting under these conditions. Here, we examine recent short-duration earthquake swarms deep beneath the southwestern margin of Long Valley Caldera, near Mammoth Mountain. We focus in particular on a swarm that occurred September 29-30, 2009. To maximally illuminate the spatial-temporal progression, we supplement catalog events by detecting additional small events with similar waveforms in the continuous data, achieving up to a 10-fold increase in the number of locatable events. We then relocate all events, using cross-correlation and a double-difference algorithm. We find that the 2009 swarm exhibits systematically decelerating upward migration, with hypocenters shallowing from 21 to 19 km depth over approximately 12 hours. This relatively high migration rate, combined with a modest maximum magnitude of 1.4 in this swarm, suggests the trigger might be ascending CO2 released from underlying magma.
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Naase, Taher; Doughty, Michael J; Button, Norman F
2005-04-01
To determine whether there is a change in the pattern of human eyeblink events under topical ocular anaesthesia. Forty male subjects, aged between 19 and 52 years and with no significant ocular surface disease, were recruited. Their spontaneous eyeblink activity, in primary eye gaze position and in silence, was recorded for 5-min periods, before and after instillation of benoxinate 0.4% eyedrops. The surface anaesthesia was confirmed by aesthesiometry. The spontaneous eyeblink rate (SEBR) decreased from 9.1+/-4.0 blinks/min to an average of 5.7+/-3.3 blinks/min, with 37 subjects showing a decreased eyeblink rate under anaesthesia. Three blink patterns were observed before anaesthesia (symmetrical, J-type and I-type) and these were essentially unchanged under anaesthesia. These studies confirm that the SEBR is usually reduced under surface anaesthesia (so is sensitive to exogenous control) but the pattern of the eyeblink activity is unchanged (so is less sensitive to exogenous control). The removal of exogenous stimuli by anaesthesia does not shift the eyeblink pattern to a single type, so indicates endogenous control.
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NASA Astrophysics Data System (ADS)
Kobayashi, T.; Ohminato, T.; Fujita, E.; Ida, Y.
2002-12-01
The volcanic activity of Miyake-jima started at 18:30 (JST) on June 26, 2000 with large ground deformation and earthquake swarms. The seismic activity started at the southern part of the island. The hypocenter distribution migrated northwestward and slipped away out of the island by early in the morning, June 27. Low frequency (LF) earthquakes with dominant frequencies of 0.2 and 0.4 Hz were first observed in the afternoon of June 27. The LF activity lasted till the first summit eruption on July 8. Earthquake Research Institute of Tokyo University and National Research Institute for Earth Science and Disaster Prevention deployed 3 CMG-3T and 4 STS-2 broadband seismometers in the island. More than 300 LF earthquakes are detected during the period from June 27 to July 8. Most of the LF events whose dominant frequency is 0.2Hz occurred before July 1, while LF events with dominant frequency of 0.4Hz mainly occurred after July 2. We determine hypocenters of these LF events by using the following technique. For each LF event, we assume a source location on a grid point in a homogeneous half-space. A reference station is chosen among all the stations. The cross correlation coefficients are computed between the waveform of the reference station and those of other stations. Then, the coefficients for all the stations are summed. In the same manner, summations of the coefficients are computed grid by grid. A grid point that gives the maximum value of the sum of the coefficients is regarded as the best estimate of the source location of the LF event under consideration. The result shows that hypocenters of LF events are spread over the southern to western part of the island and they migrate from south to the west day by day. Hypocenter migrations associated with volcanic activity have been often reported but usually for short period events. This is one of remarkable cases in which a migration of earthquakes with dominant frequencies as low as 0.2 and 0.4Hz are clearly observed.
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Signature of heavy sterile neutrinos at CEPC
NASA Astrophysics Data System (ADS)
Liao, Wei; Wu, Xiao-Hong
2018-03-01
We study the production of heavy sterile neutrino N , e+e-→N ν (ν ¯), at the Circular Electron Positron Collider (CEPC) and its l j j signal in its decay to three charged fermions. We study background events for this process which are mainly events coming from W pair production. We study the production of a single heavy sterile neutrino and the sensitivity of CEPC to the mixing of the sterile neutrino with active neutrinos. We study the production of two degenerate heavy sterile neutrinos in a low energy seesaw model by taking into account the constraints on mixings of sterile neutrinos from the neutrinoless double β decay experiment and the masses and mixings of active neutrinos. We show that CEPC under proposal has a good sensitivity to the mixing of sterile neutrinos with active neutrinos for a mass of a sterile neutrino around 100 GeV.
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Detection of Cardiopulmonary Activity and Related Abnormal Events Using Microsoft Kinect Sensor.
Al-Naji, Ali; Chahl, Javaan
2018-03-20
Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not. The proposed system extracts the signal from the abdominal-thoracic region where cardiopulmonary activity is most pronounced, using a real-time image sequence captured by Kinect v2 sensor. The proposed system shows promising results in any sleep posture, regardless of illumination conditions and unclear ROI even in the presence of a blanket, whilst being reliable, safe, and cost-effective.
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Detection of Cardiopulmonary Activity and Related Abnormal Events Using Microsoft Kinect Sensor
Chahl, Javaan
2018-01-01
Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not. The proposed system extracts the signal from the abdominal-thoracic region where cardiopulmonary activity is most pronounced, using a real-time image sequence captured by Kinect v2 sensor. The proposed system shows promising results in any sleep posture, regardless of illumination conditions and unclear ROI even in the presence of a blanket, whilst being reliable, safe, and cost-effective. PMID:29558414
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Strategies for automatic processing of large aftershock sequences
NASA Astrophysics Data System (ADS)
Kvaerna, T.; Gibbons, S. J.
2017-12-01
Aftershock sequences following major earthquakes present great challenges to seismic bulletin generation. The analyst resources needed to locate events increase with increased event numbers as the quality of underlying, fully automatic, event lists deteriorates. While current pipelines, designed a generation ago, are usually limited to single passes over the raw data, modern systems also allow multiple passes. Processing the raw data from each station currently generates parametric data streams that are later subject to phase-association algorithms which form event hypotheses. We consider a major earthquake scenario and propose to define a region of likely aftershock activity in which we will detect and accurately locate events using a separate, specially targeted, semi-automatic process. This effort may use either pattern detectors or more general algorithms that cover wider source regions without requiring waveform similarity. An iterative procedure to generate automatic bulletins would incorporate all the aftershock event hypotheses generated by the auxiliary process, and filter all phases from these events from the original detection lists prior to a new iteration of the global phase-association algorithm.
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Surprise disrupts cognition via a fronto-basal ganglia suppressive mechanism
Wessel, Jan R.; Jenkinson, Ned; Brittain, John-Stuart; Voets, Sarah H. E. M.; Aziz, Tipu Z.; Aron, Adam R.
2016-01-01
Surprising events markedly affect behaviour and cognition, yet the underlying mechanism is unclear. Surprise recruits a brain mechanism that globally suppresses motor activity, ostensibly via the subthalamic nucleus (STN) of the basal ganglia. Here, we tested whether this suppressive mechanism extends beyond skeletomotor suppression and also affects cognition (here, verbal working memory, WM). We recorded scalp-EEG (electrophysiology) in healthy participants and STN local field potentials in Parkinson's patients during a task in which surprise disrupted WM. For scalp-EEG, surprising events engage the same independent neural signal component that indexes action stopping in a stop-signal task. Importantly, the degree of this recruitment mediates surprise-related WM decrements. Intracranially, STN activity is also increased post surprise, especially when WM is interrupted. These results suggest that surprise interrupts cognition via the same fronto-basal ganglia mechanism that interrupts action. This motivates a new neural theory of how cognition is interrupted, and how distraction arises after surprising events. PMID:27088156
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Reading sky and seeing a cloud: On the relevance of events for perceptual simulation.
Ostarek, Markus; Vigliocco, Gabriella
2017-04-01
Previous research has shown that processing words with an up/down association (e.g., bird, foot) can influence the subsequent identification of visual targets in congruent location (at the top/bottom of the screen). However, as facilitation and interference were found under similar conditions, the nature of the underlying mechanisms remained unclear. We propose that word comprehension relies on the perceptual simulation of a prototypical event involving the entity denoted by a word in order to provide a general account of the different findings. In 3 experiments, participants had to discriminate between 2 target pictures appearing at the top or the bottom of the screen by pressing the left versus right button. Immediately before the targets appeared, they saw an up/down word belonging to the target's event, an up/down word unrelated to the target, or a spatially neutral control word. Prime words belonging to target event facilitated identification of targets at a stimulus onset asynchrony (SOA) of 250 ms (Experiment 1), but only when presented in the vertical location where they are typically seen, indicating that targets were integrated in the simulations activated by the prime words. Moreover, at the same SOA, there was a robust facilitation effect for targets appearing in their typical location regardless of the prime type. However, when words were presented for 100 ms (Experiment 2) or 800 ms (Experiment 3), only a location nonspecific priming effect was found, suggesting that the visual system was not activated. Implications for theories of semantic processing are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
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NASA Astrophysics Data System (ADS)
Yin, J.-J.; Yuan, D.-X.; Li, H.-C.; Cheng, H.; Li, T.-Y.; Edwards, R. L.; Lin, Y.-S.; Qin, J.-M.; Tang, W.; Zhao, Z.-Y.; Mii, H.-S.
2014-04-01
Highlight: this paper focuses on the climate variability in central China since 1300 AD, involving: 1. A well-dated, 1.5 year resolution stalagmite δ18O record from Lianhua Cave, central China; 2. Links of the δ18O record with regional dry-wet condition, monsoon intensity, and temperature over eastern China; 3. Correlations among drought events in the Lianhua record, solar irradiation, and ENSO index. We present a highly precisely 230Th/U dated, 1.5 year resolution δ18O record of an aragonite stalagmite (LHD1) collected from Lianhua Cave in Wuling mountain area of central China. The comparison of the δ18O record with the local instrumental record and historical documents exhibits at least 15 drought events in the Wuling mountain and adjacent areas during the Little Ice Age, in which some of them were corresponding to megadrought events in the broad Asian monsoonal region of China. Thus, the stalagmite δ18O record reveals variations in the summer monsoon precipitation and dry-wet condition in Wuling mountain area. The eastern China temperature varied with the solar activity, showing higher temperature under stronger solar irradiation which produces stronger summer monsoon. During Maunder, Dalton and 1900 sunspot minima, more severe drought events occurred, indicating weakening of the summer monsoon when solar activity decreased on decadal time scales. On interannual time scale, dry conditions in the studying area were prevailing under El Niño condition, which is also supported by the spectrum analysis. Hence, our record illustrates the linkage of Asian summer monsoon precipitation to solar irradiation and ENSO: wetter condition under stronger summer monsoon during warm periods and vice versa; During cold periods, the Walker circulation will shift toward central Pacific under El Niño condition, resulting further weakening of Asian summer monsoon. However, the δ18O of LHD1 record is positively correlated with temperature after ~1940 AD which is opposite to the δ18O - temperature relationship in earlier time. This anomaly relationship might be caused by the greenhouse-gas forcing.
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Not my future? Core values and the neural representation of future events.
Brosch, Tobias; Stussi, Yoann; Desrichard, Olivier; Sander, David
2018-06-01
Individuals with pronounced self-transcendence values have been shown to put greater weight on the long-term consequences of their actions when making decisions. Using functional magnetic resonance imaging, we investigated the neural mechanisms underlying the evaluation of events occurring several decades in the future as well as the role of core values in these processes. Thirty-six participants viewed a series of events, consisting of potential consequences of climate change, which could occur in the near future (around 2030), and thus would be experienced by the participants themselves, or in the far future (around 2080). We observed increased activation in anterior VMPFC (BA11), a region involved in encoding the personal significance of future events, when participants were envisioning far future events, demonstrating for the first time that the role of the VMPFC in future projection extends to the time scale of decades. Importantly, this activation increase was observed only in participants with pronounced self-transcendence values measured by self-report questionnaire, as shown by a statistically significant interaction of temporal distance and value structure. These findings suggest that future projection mechanisms are modulated by self-transcendence values to allow for a more extensive simulation of far future events. Consistent with this, these participants reported similar concern ratings for near and far future events, whereas participants with pronounced self-enhancement values were more concerned about near future events. Our findings provide a neural substrate for the tendency of individuals with pronounced self-transcendence values to consider the long-term consequences of their actions.
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The quasi-biennial oscillation of 1.7 years in ground level enhancement events
NASA Astrophysics Data System (ADS)
Velasco Herrera, V. M.; Pérez-Peraza, J.; Soon, W.; Márquez-Adame, J. C.
2018-04-01
The so-called Ground Level Enhancement events are sporadic relativistic solar particles measured at ground level by a network of cosmic ray detectors worldwide. These sporadic events are typically assumed to occur by random chance. However, we find that by studying the last 56 ground level enhancement events reported from 1966 through 2014, these events occur preferentially in the positive phase of the quasi-biennial oscillation of 1.7 year periodicity. These discrete ground level enhancement events show that there is another type of solar emission (i.e., wavelike packets) that occurs only in a specific phase of a very particular oscillation. We interpret this empirical result to support that ground level enhancement events are not a result of purely stochastic processes. We used the Morlet wavelet to analyze the phase of each of the periodicities found by the wavelet analyses and local variations of power spectral density in these sporadic events. We found quasi-regular periodicities of 10.4, 6.55, 4.12, 2.9, 1.73, 0.86, 0.61, 0.4 and 0.24 years in ground level enhancements. Although some of these quasi-biennial oscillation periodicities (i.e., oscillations operating between 0.6 and 4 years) may be interpreted as simply harmonics and overtones of the fundamental solar cycle from the underlying sun-spot magnetism phenomenon. The sources of these periodicities are still unclear. Also there is no clear mechanism for the variability of the quasi-biennial oscillation periodicities itself. The quasi-biennial oscillation periodicities are broadly considered to be a variation of solar activity, associated with the solar dynamo process. Also, the intensity of these periodicities is more important around the years of maximum solar activity because the quasi-biennial oscillation periodicities are modulated by the solar cycle where the Sun is more energetically enhanced during activity maxima. To identify the relationships among ground level enhancement, solar, and cosmic rays indices in time-frequency framework, we apply the wavelet coherence analysis. The fingerprints of solar activity and galactic cosmic rays on these phenomena can also be discerned in terms of the prominent quasi-biennial oscillation of about 1.7 years.
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2018-04-18
Employees had the opportunity to take a look under the hood of an electric vehicle on display during Kennedy Space Center’s annual Earth Day celebration. The two-day event featured approximately 50 exhibitors offering information on a variety of topics, including electric vehicles, sustainable lighting, renewable energy, Florida-friendly landscaping tips, Florida’s biking trails and more.
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Brain Activity during Performance of Naming Tasks: Comparison between Dyslexic and Regular Readers
ERIC Educational Resources Information Center
Breznitz, Zvia
2005-01-01
This research was aimed at contributing to the current understanding of the underlying factors of naming speed and the causes of naming speed deficits. Forty regular readers and 40 dyslexic university students participated in the study. Electrophysiological (Event-Related Potentials [ERPs]) and behavioral measures were employed. Behavioral…
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Proceedings of the National Academy of Education, Volume 6, 1979.
ERIC Educational Resources Information Center
National Academy of Education, Washington, DC.
As the title suggests, this publication reviews and accents the activities which took place under the aegis of the National Academy of Education during 1979. The Annual Report of the President and reports of the Spring and Fall meetings, respectively, outline: events which occurred during the year; studies, books, reviews and research either…
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USDA-ARS?s Scientific Manuscript database
Identification of microbial assemblages predominant under natural extreme climatic events will aid in our understanding of the resilience and resistance of microbial communities to climate change. From November 2010 to August 2011, the Southern High Plains (SHP) of Texas, U.S., received only 39.6 mm...
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Conundrums, paradoxes, and surprises: a brave new world of biodiversity conservation
A.E. Lugo
2012-01-01
Anthropogenic activity is altering the global disturbance regime through such processes as urbanization, deforestation, and climate change. These disturbance events alter the environmental conditions under which organisms live and adapt and trigger succession, thus setting the biota in otiion in both ecological and evolutionary space. The result is the mixing of...
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NASA Technical Reports Server (NTRS)
Dudnic, A. V.; Zaljubovski, I. I.; Kartashev, V. M.; Shmatko, E. S.
1985-01-01
Sporadic radio emission of near Earth space at the frequency of 38 MHz is shown to appear in the event of a rapid development of instabilities in the ionospheric plasma. The instabilities are generated due to primary ionospheric disturbances occurring under the influence of solar chromospheric flares.
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Track and Field: An Administrative Approach to the Science of Coaching.
ERIC Educational Resources Information Center
Steben, Ralph E.; Bell, Sam
This textbook on track and field organization and administration is directed toward the college physical education student and the track coach interested in technical, in-depth material. Each event is discussed under appropriate areas of physical categorization, with analysis of basic, biomechanical aspects of the activity. Line drawings and…
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Evidence for (Shared) Abstract Structure Underlying Children's Short and Full Passives
ERIC Educational Resources Information Center
Messenger, Katherine; Branigan, Holly P.; McLean, Janet F.
2011-01-01
In a syntactic priming paradigm, three- and four-year-old children and adults described transitive events after hearing thematically and lexically unrelated active and short passive prime descriptions. Both groups were more likely to produce full passive descriptions ("the king is being scratched by the tiger") following short passive primes ("the…
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Neural response to reward anticipation under risk is nonlinear in probabilities.
Hsu, Ming; Krajbich, Ian; Zhao, Chen; Camerer, Colin F
2009-02-18
A widely observed phenomenon in decision making under risk is the apparent overweighting of unlikely events and the underweighting of nearly certain events. This violates standard assumptions in expected utility theory, which requires that expected utility be linear (objective) in probabilities. Models such as prospect theory have relaxed this assumption and introduced the notion of a "probability weighting function," which captures the key properties found in experimental data. This study reports functional magnetic resonance imaging (fMRI) data that neural response to expected reward is nonlinear in probabilities. Specifically, we found that activity in the striatum during valuation of monetary gambles are nonlinear in probabilities in the pattern predicted by prospect theory, suggesting that probability distortion is reflected at the level of the reward encoding process. The degree of nonlinearity reflected in individual subjects' decisions is also correlated with striatal activity across subjects. Our results shed light on the neural mechanisms of reward processing, and have implications for future neuroscientific studies of decision making involving extreme tails of the distribution, where probability weighting provides an explanation for commonly observed behavioral anomalies.
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Humic substances biological activity at the plant-soil interface
Trevisan, Sara; Francioso, Ornella; Nardi, Serenella
2010-01-01
Humic substances (HS) represent the organic material mainly widespread in nature. HS have positive effects on plant physiology by improving soil structure and fertility and by influencing nutrient uptake and root architecture. The biochemical and molecular mechanisms underlying these events are only partially known. HS have been shown to contain auxin and an “auxin-like” activity of humic substances has been proposed, but support to this hypothesis is fragmentary. In this review article, we are giving an overview of available data concerning molecular structures and biological activities of humic substances, with special emphasis on their hormone-like activities. PMID:20495384
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NASA Astrophysics Data System (ADS)
Hsieh, Nan-Hung; Liao, Chung-Min
2013-04-01
Asian dust storms (ADS) events are seasonally-based meteorological phenomena that exacerbate chronic respiratory diseases. The purpose of this study was to assess human health risk from airborne dust exposure during ADS events in Taiwan. A probabilistic risk assessment framework was developed based on exposure and experimental data to quantify ADS events induced lung function decrement. The study reanalyzed experimental data from aerosol challenge in asthmatic individuals to construct the dose-response relationship between inhaled dust aerosol dose and decreasing percentage of forced expiratory volume in 1 s (%FEV1). An empirical lung deposition model was used to predict deposition fraction for size specific dust aerosols in pulmonary regions. The toxicokinetic and toxicodynamic models were used to simulate dust aerosols binding kinetics in lung airway in that %FEV1 change was also predicted. The mask respirators were applied to control the inhaled dose under dust aerosols exposure. Our results found that only 2% probability the mild ADS events were likely to cause %FEV1 decrement higher than 5%. There were 50% probability of decreasing %FEV1 exceeding 16.9, 18.9, and 7.1% in north, center, and south Taiwan under severe ADS events, respectively. Our result implicates that the use of activated carbon of mask respirators has the best efficacy for reducing inhaled dust aerosol dose, by which the %FEV1 decrement can be reduced up to less than 1%.
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Spoljaric, Albert; Seja, Patricia; Spoljaric, Inkeri; Virtanen, Mari A.; Lindfors, Jenna; Uvarov, Pavel; Summanen, Milla; Crow, Ailey K.; Hsueh, Brian; Puskarjov, Martin; Ruusuvuori, Eva; Voipio, Juha; Deisseroth, Karl; Kaila, Kai
2017-01-01
During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment. However, it is not known whether the hormonal signaling involves central pathways with direct protective effects on the perinatal brain. Here, we show that arginine vasopressin specifically activates interneurons to suppress spontaneous network events in the perinatal hippocampus. Experiments done on the altricial rat and precocial guinea pig neonate demonstrated that the effect of vasopressin is not dependent on the level of maturation (depolarizing vs. hyperpolarizing) of postsynaptic GABAA receptor actions. Thus, the fetal mammalian brain is equipped with an evolutionarily conserved mechanism well-suited to suppress energetically expensive correlated network events under conditions of reduced oxygen supply at birth. PMID:29183979
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ERIC Educational Resources Information Center
Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.
Hearings concerning the activities of the Student Loan Marketing Association (Sallie Mae) are presented. Attention is focused on a request for an exemption under federal priority for recovering money owed the Association in the event that it files for liquidation or reorganization in the future under the Bankruptcy Act. It is noted that two goals…
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Castellini, Giovanni; Wu, Frederick C W; Finn, Joseph D; OʼNeill, Terrence W; Lean, Michael E J; Pendleton, Neil; Rastrelli, Giulia; Rutter, Martin K; Gacci, Mauro; Ricca, Valdo; Maggi, Mario
2016-01-01
Depression and lower urinary tract symptoms (LUTSs) have been found to co-occur among aging men. The present study attempted to clarify the nature of this relationship, considering adverse life events as potential moderators and the inflammation as an underlying biological mechanism. The relationship between depression and LUTS was evaluated using data from the European Male Ageing Study, the largest multicenter population-based study of aging in European men. The sample included 3369 men who were assessed by means of several self-reported questionnaires, including the Beck Depression Inventory-II, the International Prostate Symptom Score, and the Adverse Life Events Scale. Participants were asked to provide information regarding general health and life-style, and medical comorbidities. Biological measures including prostate-specific antigen, testosterone, and C-reactive protein were measured. LUTS and depressive symptoms were correlated (R = 0.32, β = .10, p < .001), even after adjusting for life-style, psychological, and medical variables. A history of adverse life events was associated with both higher LUTS and Beck Depression Inventory scores. Furthermore, adverse life events moderated the LUTS-depression association (F = 22.62, b = 0.061, p < .001), which increased as a function of the number of life events. C-reactive protein was found to mediate the LUTS-depression association. This mediation effect was moderated by number of adverse life events. Participants with a history of adverse life events represent a vulnerable population in whom the association between somatic and depressive symptoms is stronger. One of the biological mechanisms underlying this association could be an activation of the central inflammatory signaling pathways.
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Ice Crystal Icing Research at NASA
NASA Technical Reports Server (NTRS)
Flegel, Ashlie B.
2017-01-01
Ice crystals found at high altitude near convective clouds are known to cause jet engine power-loss events. These events occur due to ice crystals entering a propulsion system's core flowpath and accreting ice resulting in events such as uncommanded loss of thrust (rollback), engine stall, surge, and damage due to ice shedding. As part of a community with a growing need to understand the underlying physics of ice crystal icing, NASA has been performing experimental efforts aimed at providing datasets that can be used to generate models to predict the ice accretion inside current and future engine designs. Fundamental icing physics studies on particle impacts, accretion on a single airfoil, and ice accretions observed during a rollback event inside a full-scale engine in the Propulsion Systems Laboratory are summarized. Low fidelity code development using the results from the engine tests which identify key parameters for ice accretion risk and the development of high fidelity codes are described. These activities have been conducted internal to NASA and through collaboration efforts with industry, academia, and other government agencies. The details of the research activities and progress made to date in addressing ice crystal icing research challenges are discussed.
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Ice Crystal Icing Research at NASA
NASA Technical Reports Server (NTRS)
Flegel, Ashlie B.
2017-01-01
Ice crystals found at high altitude near convective clouds are known to cause jet engine power-loss events. These events occur due to ice crystals entering a propulsion systems core flowpath and accreting ice resulting in events such as uncommanded loss of thrust (rollback), engine stall, surge, and damage due to ice shedding. As part of a community with a growing need to understand the underlying physics of ice crystal icing, NASA has been performing experimental efforts aimed at providing datasets that can be used to generate models to predict the ice accretion inside current and future engine designs. Fundamental icing physics studies on particle impacts, accretion on a single airfoil, and ice accretions observed during a rollback event inside a full-scale engine in the Propulsion Systems Laboratory are summarized. Low fidelity code development using the results from the engine tests which identify key parameters for ice accretion risk and the development of high fidelity codes are described. These activities have been conducted internal to NASA and through collaboration efforts with industry, academia, and other government agencies. The details of the research activities and progress made to date in addressing ice crystal icing research challenges are discussed.
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Central noradrenergic mechanisms and the acute stress response during painful stimulation.
Chapman, C Richard; Bradshaw, David H; Donaldson, Gary W; Jacobson, Robert C; Nakamura, Yoshio
2014-12-01
Events that threaten tissue integrity including noxious stimulation activate central noradrenergic circuits, particularly locus coeruleus and its projections. Recent advances in theory hold that an adaptive, defensive shift in brain activity takes place in response to threat. In principle, this shift may accentuate the autonomic and central biomarkers of the perception of painful events and the experience of pain itself. We have examined the effects of an alpha-2 agonist on pupil dilation responses, skin conductance responses, near field somatosensory evoked potentials and pain reports in normal volunteers undergoing repeated trials of painful fingertip stimulation delivered at low, medium and high intensities. In a double-blinded study, 114 healthy male and female volunteers underwent repeated noxious stimulation under baseline, placebo and active drug conditions where the active drug was the alpha-2 agonist tizanidine 4 mg. In contrast to baseline and placebo conditions, tizanidine 4 mg significantly reduced the magnitudes of the mean pupil dilation response, the mean skin conductance response, the mean near field somatosensory evoked potential peak-to-peak amplitude and the mean pain intensity rating. Stimulus intensity significantly altered all three biomarkers and the pain report in a graded fashion. There were no sex differences. These findings support the hypotheses that painful events activate central noradrenergic circuits, and that these circuits play a role in the autonomic and central arousal associated with pain. © The Author(s) 2014.
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Aron, Adam R.
2013-01-01
When an unexpected event occurs in everyday life (e.g., a car honking), one experiences a slowing down of ongoing action (e.g., of walking into the street). Motor slowing following unexpected events is a ubiquitous phenomenon, both in laboratory experiments as well as such everyday situations, yet the underlying mechanism is unknown. We hypothesized that unexpected events recruit the same inhibition network in the brain as does complete cancellation of an action (i.e., action-stopping). Using electroencephalography and independent component analysis in humans, we show that a brain signature of successful outright action-stopping also exhibits activity following unexpected events, and more so in blocks with greater motor slowing. Further, using transcranial magnetic stimulation to measure corticospinal excitability, we show that an unexpected event has a global motor suppressive effect, just like outright action-stopping. Thus, unexpected events recruit a common mechanism with outright action-stopping, moreover with global suppressive effects. These findings imply that we can now leverage the considerable extant knowledge of the neural architecture and functional properties of the stopping system to better understand the processing of unexpected events, including perhaps how they induce distraction via global suppression. PMID:24259571
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NASA Astrophysics Data System (ADS)
Balasis, Georgios; Potirakis, Stelios M.; Papadimitriou, Constantinos; Zitis, Pavlos I.; Eftaxias, Konstantinos
2015-04-01
The field of study of complex systems considers that the dynamics of complex systems are founded on universal principles that may be used to describe a great variety of scientific and technological approaches of different types of natural, artificial, and social systems. We apply concepts of the nonextensive statistical physics, on time-series data of observable manifestations of the underlying complex processes ending up to different extreme events, in order to support the suggestion that a dynamical analogy characterizes the generation of a single magnetic storm, solar flare, earthquake (in terms of pre-seismic electromagnetic signals) , epileptic seizure, and economic crisis. The analysis reveals that all the above mentioned different extreme events can be analyzed within similar mathematical framework. More precisely, we show that the populations of magnitudes of fluctuations included in all the above mentioned pulse-like-type time series follow the traditional Gutenberg-Richter law as well as a nonextensive model for earthquake dynamics, with similar nonextensive q-parameter values. Moreover, based on a multidisciplinary statistical analysis we show that the extreme events are characterized by crucial common symptoms, namely: (i) high organization, high compressibility, low complexity, high information content; (ii) strong persistency; and (iii) existence of clear preferred direction of emerged activities. These symptoms clearly discriminate the appearance of the extreme events under study from the corresponding background noise.
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Zhou, Shang-Ming; Hill, Rebecca A; Morgan, Kelly; Stratton, Gareth; Gravenor, Mike B; Bijlsma, Gunnar; Brophy, Sinead
2015-05-11
To classify wear and non-wear time of accelerometer data for accurately quantifying physical activity in public health or population level research. A bi-moving-window-based approach was used to combine acceleration and skin temperature data to identify wear and non-wear time events in triaxial accelerometer data that monitor physical activity. Local residents in Swansea, Wales, UK. 50 participants aged under 16 years (n=23) and over 17 years (n=27) were recruited in two phases: phase 1: design of the wear/non-wear algorithm (n=20) and phase 2: validation of the algorithm (n=30). Participants wore a triaxial accelerometer (GeneActiv) against the skin surface on the wrist (adults) or ankle (children). Participants kept a diary to record the timings of wear and non-wear and were asked to ensure that events of wear/non-wear last for a minimum of 15 min. The overall sensitivity of the proposed method was 0.94 (95% CI 0.90 to 0.98) and specificity 0.91 (95% CI 0.88 to 0.94). It performed equally well for children compared with adults, and females compared with males. Using surface skin temperature data in combination with acceleration data significantly improved the classification of wear/non-wear time when compared with methods that used acceleration data only (p<0.01). Using either accelerometer seismic information or temperature information alone is prone to considerable error. Combining both sources of data can give accurate estimates of non-wear periods thus giving better classification of sedentary behaviour. This method can be used in population studies of physical activity in free-living environments. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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AgMIP Regional Activities in a Global Framework: The Brazil Experience
NASA Technical Reports Server (NTRS)
Assad, Eduardo D.; Marin, Fabio R.; Valdivia, Roberto O.; Rosenzweig, Cynthia E.
2012-01-01
Climate variability and change are projected to increate the frequency of extreme high-temperature events, floods, and droughts, which can lead to subsequent changes in soil moister in many locations (Alexandrov and Hoogenboom, 2000). In Brazil, observations reveal a tendency for increasing frequency of extreme rainfall events particularly in south Brazil (Alexander et al., 2006; Carvalho et al., 2014; Groissman et al., 2005), as well as projections for increasing extremes in both maximum and minimum temperatures and high spatial variability for rainfall under the IPCC SRES A2 and B2 scenarios (Marengo et al., 2009).
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Ice-shelf collapse from subsurface warming as a trigger for Heinrich events
Marcott, Shaun A.; Clark, Peter U.; Padman, Laurie; Klinkhammer, Gary P.; Springer, Scott R.; Liu, Zhengyu; Otto-Bliesner, Bette L.; Carlson, Anders E.; Ungerer, Andy; Padman, June; He, Feng; Cheng, Jun; Schmittner, Andreas
2011-01-01
Episodic iceberg-discharge events from the Hudson Strait Ice Stream (HSIS) of the Laurentide Ice Sheet, referred to as Heinrich events, are commonly attributed to internal ice-sheet instabilities, but their systematic occurrence at the culmination of a large reduction in the Atlantic meridional overturning circulation (AMOC) indicates a climate control. We report Mg/Ca data on benthic foraminifera from an intermediate-depth site in the northwest Atlantic and results from a climate-model simulation that reveal basin-wide subsurface warming at the same time as large reductions in the AMOC, with temperature increasing by approximately 2 °C over a 1–2 kyr interval prior to a Heinrich event. In simulations with an ocean model coupled to a thermodynamically active ice shelf, the increase in subsurface temperature increases basal melt rate under an ice shelf fronting the HSIS by a factor of approximately 6. By analogy with recent observations in Antarctica, the resulting ice-shelf loss and attendant HSIS acceleration would produce a Heinrich event. PMID:21808034
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Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP
Porta, Maura; Diaz-Sylvester, Paula L.; Neumann, Jake T.; Escobar, Ariel L.; Fleischer, Sidney
2012-01-01
Coupled gating (synchronous openings and closures) of groups of skeletal muscle ryanodine receptors (RyR1), which mimics RyR1-mediated Ca2+ release underlying Ca2+ sparks, was first described by Marx et al. (Marx SO, Ondrias K, Marks AR. Science 281: 818–821, 1998). The nature of the RyR1-RyR1 interactions for coupled gating still needs to be characterized. Consequently, we defined planar lipid bilayer conditions where ∼25% of multichannel reconstitutions contain mixtures of coupled and independently gating RyR1. In ∼10% of the cases, all RyRs (2–10 channels; most frequently 3–4) gated in coupled fashion, allowing for quantification. Our results indicated that coupling required cytosolic solutions containing ATP/Mg2+ and high (50 mM) luminal Ca2+ (Calum) or Sr2+ solutions. Bursts of coupled activity (events) started and ended abruptly, with all channels activating/deactivating within ∼300 μs. Coupled RyR1 were heterogeneous, where highly active RyR1 (“drivers”) seemed open during the entire coupled event (Po = 1), while other RyR1s (“followers”) displayed abundant flickering and smaller amplitude. Drivers mean open time increased with cytosolic Ca2+ (Cacyt) or caffeine, whereas followers flicker frequency was Cacyt independent and more sensitive to inhibition by cytosolic Mg2+. Coupled events were insensitive to varying lumen-to-cytosol Ca2+ fluxes from ∼1 to 8 pA, which does not corroborate coupling of neighboring RyR1 by local Ca2+-induced Ca2+ release. However, coupling requires specific Calum sites, as it was lost when Calum was replaced by luminal Ba2+ or Mg2+. In summary, coupled events reveal complex interactions among heterogeneous RyR1, differentially modulated by cytosolic ATP/Mg2+, Cacyt, and Calum, which under cell-like ionic conditions may parallel synchronous RyR1 gating during Ca2+ sparks. PMID:22785120
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NASA Technical Reports Server (NTRS)
Spann, J. F., Jr.; Germany, G. A.; Brittnacher, M. J.; Parks, G. K.; Elsen, R.
1997-01-01
The January 10-11, 1997 magnetic cloud event provided a rare opportunity to study auroral energy deposition under varying but intense IMF conditions. The Wind spacecraft located about 100 RE upstream monitored the IMF and plasma parameters during the passing of the cloud. The Polar Ultraviolet Imager (UVI) observed the aurora[ precipitation during the first encounter of the cloud with Earth's magnetosphere and during several subsequent substorm events. The UVI has the unique capability of measuring the energy flux and characteristic energy of the precipitating electrons through the use of narrow band filters that distinguish short and long wavelength molecular nitrogen emissions. The spatial and temporal characteristics of the precipitating electron energy will be discussed beginning with the inception of the event at the Earth early January 1 Oth and continuing through the subsidence of auroral activity on January 11th.
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TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
Rathinam, Vijay A.K.; Vanaja, Sivapriya Kailasan; Waggoner, Lisa; Sokolovska, Anna; Becker, Christine; Stuart, Lynda M.; Leong, John M.; Fitzgerald, Katherine A.
2013-01-01
SUMMARY Systemic infections with Gram-negative bacteria are characterized by high mortality rates due to the “sepsis syndrome,” a widespread and uncontrolled inflammatory response. Though it is well recognized that the immune response during Gram-negative bacterial infection is initiated after the recognition of endotoxin by Toll-like receptor 4, the molecular mechanisms underlying the detrimental inflammatory response during Gram-negative bacteremia remain poorly defined. Here, we identify a TRIF pathway that licenses NLRP3 inflammasome activation by all Gram-negative bacteria. By engaging TRIF, Gram-negative bacteria activate caspase-11. TRIF activates caspase-11 via type I IFN signaling, an event that is both necessary and sufficient for caspase-11 induction and autoactivation. Caspase-11 subsequently synergizes with the assembled NLRP3 inflammasome to regulate caspase-1 activation and leads to caspase-1-independent cell death. These events occur specifically during infection with Gram-negative, but not Gram-positive, bacteria. The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection. PMID:22819539
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Neural mechanism underlying autobiographical memory modulated by remoteness and emotion
NASA Astrophysics Data System (ADS)
Ge, Ruiyang; Fu, Yan; Wang, DaHua; Yao, Li; Long, Zhiying
2012-03-01
Autobiographical memory is the ability to recollect past events from one's own life. Both emotional tone and memory remoteness can influence autobiographical memory retrieval along the time axis of one's life. Although numerous studies have been performed to investigate brain regions involved in retrieving processes of autobiographical memory, the effect of emotional tone and memory age on autobiographical memory retrieval remains to be clarified. Moreover, whether the involvement of hippocampus in consolidation of autobiographical events is time dependent or independent has been controversial. In this study, we investigated the effect of memory remoteness (factor1: recent and remote) and emotional valence (factor2: positive and negative) on neural correlates underlying autobiographical memory by using functional magnetic resonance imaging (fMRI) technique. Although all four conditions activated some common regions known as "core" regions in autobiographical memory retrieval, there are some other regions showing significantly different activation for recent versus remote and positive versus negative memories. In particular, we found that bilateral hippocampal regions were activated in the four conditions regardless of memory remoteness and emotional valence. Thus, our study confirmed some findings of previous studies and provided further evidence to support the multi-trace theory which believes that the role of hippocampus involved in autobiographical memory retrieval is time-independent and permanent in memory consolidation.
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Minadakis, George; Ventouras, Errikos; Gatzonis, Stylianos D; Siatouni, Anna; Tsekou, Hara; Kalatzis, Ioannis; Sakas, Damianos E; Stonham, John
2014-04-01
Recent cross-disciplinary literature suggests a dynamical analogy between earthquakes and epileptic seizures. This study extends the focus of inquiry for the applicability of models for earthquake dynamics to examine both scalp-recorded and intracranial electroencephalogram recordings related to epileptic seizures. First, we provide an updated definition of the electric event in terms of magnitude and we focus on the applicability of (i) a model for earthquake dynamics, rooted in a nonextensive Tsallis framework, (ii) the traditional Gutenberg and Richter law and (iii) an alternative method for the magnitude-frequency relation for earthquakes. Second, we apply spatiotemporal analysis in terms of nonextensive statistical physics and we further examine the behavior of the parameters included in the nonextensive formula for both types of electroencephalogram recordings under study. We confirm the previously observed power-law distribution, showing that the nonextensive formula can adequately describe the sequences of electric events included in both types of electroencephalogram recordings. We also show the intermittent behavior of the epileptic seizure cycle which is analogous to the earthquake cycles and we provide evidence of self-affinity of the regional electroencephalogram epileptic seizure activity. This study may provide a framework for the analysis and interpretation of epileptic brain activity and other biological phenomena with similar underlying dynamical mechanisms.
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Learning under uncertainty in smart home environments.
Zhang, Shuai; McClean, Sally; Scotney, Bryan; Nugent, Chris
2008-01-01
Technologies and services for the home environment can provide levels of independence for elderly people to support 'ageing in place'. Learning inhabitants' patterns of carrying out daily activities is a crucial component of these technological solutions with sensor technologies being at the core of such smart environments. Nevertheless, identifying high-level activities from low-level sensor events can be a challenge, as information may be unreliable resulting in incomplete data. Our work addresses the issues of learning in the presence of incomplete data along with the identification and the prediction of inhabitants and their activities under such uncertainty. We show via the evaluation results that our approach also offers the ability to assess the impact of various sensors in the activity recognition process. The benefit of this work is that future predictions can be utilised in a proposed intervention mechanism in a real smart home environment.
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Weiler, Martin; Duscher, Georg Gerhard; Wetscher, Monika; Walochnik, Julia
2017-02-01
The abundance of questing ticks depends on various factors. In this study, the impact of a major flood event on tick abundance and activity was observed. Ticks were collected on a weekly basis in two approximately 2 km 2 large floodplain areas on the inner and the outer bank of the river Danube north of Vienna, Austria. In 2013 before a 200 year flood event, an average of 55 ticks per hour was collected in the area on the outer bank and 21 ticks per hour in the area on the inner bank. After the flood event the tick activity was massively reduced, with 12 ticks per hour on the outer bank and 1.1 ticks per hour on the inner bank. The most distinctive factor between the two areas was the level of sediment after the flooding, with almost no sediment in the outer bank, whereas on the inner bank the average height of sediment was 270 mm. Our data indicate the residual sediment has a greater impact on tick abundance and activity than the flooding itself. Besides the direct effect of ticks being buried under the sediment, there may be important indirect effects of the sediment on the habitat of the ticks and/or the host animals. We assume that this is the reason for the generally significantly lower numbers of questing ticks in this area on the inner bank of the Danube in this region, with periodical flood events.
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30 CFR 285.636 - What notices must I provide MMS following approval of my COP?
Code of Federal Regulations, 2010 CFR
2010-07-01
... approval of my COP? 285.636 Section 285.636 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... SHELF Plans and Information Requirements Activities Under An Approved Cop § 285.636 What notices must I provide MMS following approval of my COP? You must notify MMS in writing of the following events, within...
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Increased Error-Related Negativity (ERN) in Childhood Anxiety Disorders: ERP and Source Localization
ERIC Educational Resources Information Center
Ladouceur, Cecile D.; Dahl, Ronald E.; Birmaher, Boris; Axelson, David A.; Ryan, Neal D.
2006-01-01
Background: In this study we used event-related potentials (ERPs) and source localization analyses to track the time course of neural activity underlying response monitoring in children diagnosed with an anxiety disorder compared to age-matched low-risk normal controls. Methods: High-density ERPs were examined following errors on a flanker task…
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Natural and social factors influencing forest fire occurrence at a local spatial scale
Maria Luisa Chas-Amil; Julia M. Touza; Jeffrey P. Prestemon; Colin J. McClean
2012-01-01
Development of efficient forest fire policies requires an understanding of the underlying reasons behind forest fire ignitions. Globally, there is a close relationship between forest fires and human activities, i.e., fires understood as human events due to negligence (e.g., agricultural burning escapes), and deliberate actions (e.g., pyromania, revenge, land use change...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-28
... following information collection to the Office of Management and Budget (OMB) for review and clearance under... from the credit union's offices to avoid the simultaneous loss of both sets of records in the event of...-2861, Email: [email protected] . OMB Contact: Office of Management and Budget, ATTN: Desk Officer for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-19
... following information collection to the Office of Management and Budget (OMB) for review and clearance under... loss of both sets of records in the event of a disaster. Part 749 requires a written vital records...- 2861, Email: [email protected] . OMB Contact: Office of Management and Budget, ATTN: Desk Officer for...
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48 CFR 301.605 - Contracting Officer designation of Contracting Officer Technical Representative.
Code of Federal Regulations, 2014 CFR
2014-10-01
... under HHS' FAC-COTR program before delegating authority to that individual to act as a COTR. Even if an individual is FAC-COTR-certified, a candidate becomes a COTR only when a Contracting Officer provides in... order file the individual's active FAC-COTR certificate. In the event that the HCA has granted an...
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48 CFR 301.605 - Contracting Officer designation of Contracting Officer Technical Representative.
Code of Federal Regulations, 2013 CFR
2013-10-01
... under HHS' FAC-COTR program before delegating authority to that individual to act as a COTR. Even if an individual is FAC-COTR-certified, a candidate becomes a COTR only when a Contracting Officer provides in... order file the individual's active FAC-COTR certificate. In the event that the HCA has granted an...
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48 CFR 301.605 - Contracting Officer designation of Contracting Officer Technical Representative.
Code of Federal Regulations, 2010 CFR
2010-10-01
... under HHS' FAC-COTR program before delegating authority to that individual to act as a COTR. Even if an individual is FAC-COTR-certified, a candidate becomes a COTR only when a Contracting Officer provides in... order file the individual's active FAC-COTR certificate. In the event that the HCA has granted an...
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48 CFR 301.605 - Contracting Officer designation of Contracting Officer Technical Representative.
Code of Federal Regulations, 2011 CFR
2011-10-01
... under HHS' FAC-COTR program before delegating authority to that individual to act as a COTR. Even if an individual is FAC-COTR-certified, a candidate becomes a COTR only when a Contracting Officer provides in... order file the individual's active FAC-COTR certificate. In the event that the HCA has granted an...
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48 CFR 301.605 - Contracting Officer designation of Contracting Officer Technical Representative.
Code of Federal Regulations, 2012 CFR
2012-10-01
... under HHS' FAC-COTR program before delegating authority to that individual to act as a COTR. Even if an individual is FAC-COTR-certified, a candidate becomes a COTR only when a Contracting Officer provides in... order file the individual's active FAC-COTR certificate. In the event that the HCA has granted an...
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NASA Astrophysics Data System (ADS)
Aad, G.; Abajyan, T.; Abbott, B.; Abdallah, J.; Khalek, S. Abdel; Abdinov, O.; Aben, R.; Abi, B.; Abolins, M.; AbouZeid, O. S.; Abramowicz, H.; Abreu, H.; Abulaiti, Y.; Acharya, B. S.; Adamczyk, L.; Adams, D. L.; Addy, T. N.; Adelman, J.; Adomeit, S.; Adye, T.; Agatonovic-Jovin, T.; Aguilar-Saavedra, J. A.; Agustoni, M.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Albert, J.; Albrand, S.; Verzini, M. J. Alconada; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Alimonti, G.; Alio, L.; Alison, J.; Allbrooke, B. M. M.; Allison, L. J.; Allport, P. P.; Allwood-Spiers, S. E.; Almond, J.; Aloisio, A.; Alon, R.; Alonso, A.; Alonso, F.; Alpigiani, C.; Altheimer, A.; Gonzalez, B. Alvarez; Alviggi, M. G.; Amako, K.; Coutinho, Y. Amaral; Amelung, C.; Amidei, D.; Ammosov, V. V.; Santos, S. P. Amor Dos; Amorim, A.; Amoroso, S.; Amram, N.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, G.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Anduaga, X. S.; Angelidakis, S.; Anger, P.; Angerami, A.; Anghinolfi, F.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antonaki, A.; Antonelli, M.; Antonov, A.; Antos, J.; Anulli, F.; Aoki, M.; Bella, L. Aperio; Apolle, R.; Arabidze, G.; Aracena, I.; Arai, Y.; Araque, J. P.; Arce, A. T. H.; Arguin, J.-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnal, V.; Arslan, O.; Artamonov, A.; Artoni, G.; Asai, S.; Asbah, N.; Ashkenazi, A.; Ask, S.; Åsman, B.; Asquith, L.; Assamagan, K.; Astalos, R.; Atkinson, M.; Atlay, N. B.; Auerbach, B.; Auge, E.; Augsten, K.; Aurousseau, M.; Avolio, G.; Azuelos, G.; Azuma, Y.; Baak, M. A.; Bacci, C.; Bach, A. M.; Bachacou, H.; Bachas, K.; Backes, M.; Backhaus, M.; Mayes, J. Backus; Badescu, E.; Bagiacchi, P.; Bagnaia, P.; Bai, Y.; Bailey, D. C.; Bain, T.; Baines, J. T.; Baker, O. K.; Baker, S.; Balek, P.; Balli, F.; Banas, E.; Banerjee, Sw.; Bangert, A.; Bannoura, A. A. E.; Bansal, V.; Bansil, H. S.; Barak, L.; Baranov, S. P.; Barber, T.; Barberio, E. L.; Barberis, D.; Barbero, M.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B. M.; Barnett, R. M.; Barnovska, Z.; Baroncelli, A.; Barone, G.; Barr, A. J.; Barreiro, F.; da Costa, J. Barreiro Guimarães; Bartoldus, R.; Barton, A. E.; Bartos, P.; Bartsch, V.; Bassalat, A.; Basye, A.; Bates, R. L.; Batkova, L.; Batley, J. R.; Battistin, M.; Bauer, F.; Bawa, H. S.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Bechtle, P.; Beck, H. P.; Becker, K.; Becker, S.; Beckingham, M.; Becot, C.; Beddall, A. J.; Beddall, A.; Bedikian, S.; Bednyakov, V. A.; Bee, C. P.; Beemster, L. J.; Beermann, T. A.; Begel, M.; Behr, K.; Belanger-Champagne, C.; Bell, P. J.; Bell, W. H.; Bella, G.; Bellagamba, L.; Bellerive, A.; Bellomo, M.; Belloni, A.; Belotskiy, K.; Beltramello, O.; Benary, O.; Benchekroun, D.; Bendtz, K.; Benekos, N.; Benhammou, Y.; Noccioli, E. Benhar; Garcia, J. A. Benitez; Benjamin, D. P.; Bensinger, J. R.; Benslama, K.; Bentvelsen, S.; Berge, D.; Kuutmann, E. Bergeaas; Berger, N.; Berghaus, F.; Berglund, E.; Beringer, J.; Bernard, C.; Bernat, P.; Bernius, C.; Bernlochner, F. U.; Berry, T.; Berta, P.; Bertella, C.; Bertolucci, F.; Besana, M. I.; Besjes, G. J.; Bessidskaia, O.; Besson, N.; Betancourt, C.; Bethke, S.; Bhimji, W.; Bianchi, R. M.; Bianchini, L.; Bianco, M.; Biebel, O.; Bieniek, S. P.; Bierwagen, K.; Biesiada, J.; Biglietti, M.; De Mendizabal, J. Bilbao; Bilokon, H.; Bindi, M.; Binet, S.; Bingul, A.; Bini, C.; Black, C. W.; Black, J. E.; Black, K. M.; Blackburn, D.; Blair, R. E.; Blanchard, J.-B.; Blazek, T.; Bloch, I.; Blocker, C.; Blum, W.; Blumenschein, U.; Bobbink, G. J.; Bobrovnikov, V. S.; Bocchetta, S. S.; Bocci, A.; Boddy, C. R.; Boehler, M.; Boek, J.; Boek, T. T.; Bogaerts, J. A.; Bogdanchikov, A. G.; Bogouch, A.; Bohm, C.; Bohm, J.; Boisvert, V.; Bold, T.; Boldea, V.; Boldyrev, A. S.; Bolnet, N. M.; Bomben, M.; Bona, M.; Boonekamp, M.; Borisov, A.; Borissov, G.; Borri, M.; Borroni, S.; Bortfeldt, J.; Bortolotto, V.; Bos, K.; Boscherini, D.; Bosman, M.; Boterenbrood, H.; Boudreau, J.; Bouffard, J.; Bouhova-Thacker, E. V.; Boumediene, D.; Bourdarios, C.; Bousson, N.; Boutouil, S.; Boveia, A.; Boyd, J.; Boyko, I. R.; Bozovic-Jelisavcic, I.; Bracinik, J.; Branchini, P.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J. E.; Braun, H. M.; Brazzale, S. F.; Brelier, B.; Brendlinger, K.; Brennan, A. J.; Brenner, R.; Bressler, S.; Bristow, K.; Bristow, T. M.; Britton, D.; Brochu, F. M.; Brock, I.; Brock, R.; Bromberg, C.; Bronner, J.; Brooijmans, G.; Brooks, T.; Brooks, W. K.; Brosamer, J.; Brost, E.; Brown, G.; Brown, J.; Renstrom, P. A. Bruckman de; Bruncko, D.; Bruneliere, R.; Brunet, S.; Bruni, A.; Bruni, G.; Bruschi, M.; Bryngemark, L.; Buanes, T.; Buat, Q.; Bucci, F.; Buchholz, P.; Buckingham, R. M.; Buckley, A. G.; Buda, S. I.; Budagov, I. A.; Buehrer, F.; Bugge, L.; Bugge, M. K.; Bulekov, O.; Bundock, A. C.; Burckhart, H.; Burdin, S.; Burghgrave, B.; Burke, S.; Burmeister, I.; Busato, E.; Büscher, V.; Bussey, P.; Buszello, C. P.; Butler, B.; Butler, J. M.; Butt, A. I.; Buttar, C. M.; Butterworth, J. M.; Butti, P.; Buttinger, W.; Buzatu, A.; Byszewski, M.; Urbán, S. Cabrera; Caforio, D.; Cakir, O.; Calafiura, P.; Calderini, G.; Calfayan, P.; Calkins, R.; Caloba, L. P.; Calvet, D.; Calvet, S.; Toro, R. Camacho; Camarda, S.; Cameron, D.; Caminada, L. M.; Armadans, R. Caminal; Campana, S.; Campanelli, M.; Campoverde, A.; Canale, V.; Canepa, A.; Cantero, J.; Cantrill, R.; Cao, T.; Garrido, M. D. M. Capeans; Caprini, I.; Caprini, M.; Capua, M.; Caputo, R.; Cardarelli, R.; Carli, T.; Carlino, G.; Carminati, L.; Caron, S.; Carquin, E.; Carrillo-Montoya, G. D.; Carter, J. R.; Carvalho, J.; Casadei, D.; Casado, M. P.; Castaneda-Miranda, E.; Castelli, A.; Gimenez, V. Castillo; Castro, N. F.; Catastini, P.; Catinaccio, A.; Catmore, J. R.; Cattai, A.; Cattani, G.; Caughron, S.; Cavaliere, V.; Cavalli, D.; Cavalli-Sforza, M.; Cavasinni, V.; Ceradini, F.; Cerio, B.; Cerny, K.; Cerqueira, A. S.; Cerri, A.; Cerrito, L.; Cerutti, F.; Cerv, M.; Cervelli, A.; Cetin, S. A.; Chafaq, A.; Chakraborty, D.; Chalupkova, I.; Chan, K.; Chang, P.; Chapleau, B.; Chapman, J. D.; Charfeddine, D.; Charlton, D. G.; Chau, C. C.; Barajas, C. A. Chavez; Cheatham, S.; Chegwidden, A.; Chekanov, S.; Chekulaev, S. V.; Chelkov, G. A.; Chelstowska, M. A.; Chen, C.; Chen, H.; Chen, K.; Chen, L.; Chen, S.; Chen, X.; Chen, Y.; Cheng, H. C.; Cheng, Y.; Cheplakov, A.; El Moursli, R. Cherkaoui; Chernyatin, V.; Cheu, E.; Chevalier, L.; Chiarella, V.; Chiefari, G.; Childers, J. T.; Chilingarov, A.; Chiodini, G.; Chisholm, A. S.; Chislett, R. T.; Chitan, A.; Chizhov, M. V.; Chouridou, S.; Chow, B. K. B.; Christidi, I. A.; Chromek-Burckhart, D.; Chu, M. L.; Chudoba, J.; Chytka, L.; Ciapetti, G.; Ciftci, A. K.; Ciftci, R.; Cinca, D.; Cindro, V.; Ciocio, A.; Cirkovic, P.; Citron, Z. H.; Citterio, M.; Ciubancan, M.; Clark, A.; Clark, P. J.; Clarke, R. N.; Cleland, W.; Clemens, J. C.; Clement, B.; Clement, C.; Coadou, Y.; Cobal, M.; Coccaro, A.; Cochran, J.; Coffey, L.; Cogan, J. G.; Coggeshall, J.; Cole, B.; Cole, S.; Colijn, A. P.; Collins-Tooth, C.; Collot, J.; Colombo, T.; Colon, G.; Compostella, G.; Muiño, P. Conde; Coniavitis, E.; Conidi, M. C.; Connell, S. H.; Connelly, I. A.; Consonni, S. M.; Consorti, V.; Constantinescu, S.; Conta, C.; Conti, G.; Conventi, F.; Cooke, M.; Cooper, B. D.; Cooper-Sarkar, A. M.; Cooper-Smith, N. J.; Copic, K.; Cornelissen, T.; Corradi, M.; Corriveau, F.; Corso-Radu, A.; Cortes-Gonzalez, A.; Cortiana, G.; Costa, G.; Costa, M. J.; Costanzo, D.; Côté, D.; Cottin, G.; Cowan, G.; Cox, B. E.; Cranmer, K.; Cree, G.; Crépé-Renaudin, S.; Crescioli, F.; Ortuzar, M. Crispin; Cristinziani, M.; Crosetti, G.; Cuciuc, C.-M.; Donszelmann, T. Cuhadar; Cummings, J.; Curatolo, M.; Cuthbert, C.; Czirr, H.; Czodrowski, P.; Czyczula, Z.; D'Auria, S.; D'Onofrio, M.; Da Cunha Sargedas De Sousa, M. J.; Da Via, C.; Dabrowski, W.; Dafinca, A.; Dai, T.; Dale, O.; Dallaire, F.; Dallapiccola, C.; Dam, M.; Daniells, A. C.; Hoffmann, M. Dano; Dao, V.; Darbo, G.; Darlea, G. L.; Darmora, S.; Dassoulas, J. A.; Davey, W.; David, C.; Davidek, T.; Davies, E.; Davies, M.; Davignon, O.; Davison, A. R.; Davison, P.; Davygora, Y.; Dawe, E.; Dawson, I.; Daya-Ishmukhametova, R. K.; De, K.; de Asmundis, R.; De Castro, S.; De Cecco, S.; de Graat, J.; De Groot, N.; de Jong, P.; De La Taille, C.; De la Torre, H.; De Lorenzi, F.; De Nooij, L.; De Pedis, D.; De Salvo, A.; De Sanctis, U.; De Santo, A.; De Vivie De Regie, J. B.; De Zorzi, G.; Dearnaley, W. J.; Debbe, R.; Debenedetti, C.; Dechenaux, B.; Dedovich, D. V.; Degenhardt, J.; Deigaard, I.; Del Peso, J.; Del Prete, T.; Deliot, F.; Deliyergiyev, M.; Dell'Acqua, A.; Dell'Asta, L.; Dell'Orso, M.; Della Pietra, M.; della Volpe, D.; Delmastro, M.; Delsart, P. A.; Deluca, C.; Demers, S.; Demichev, M.; Demilly, A.; Denisov, S. P.; Derendarz, D.; Derkaoui, J. E.; Derue, F.; Dervan, P.; Desch, K.; Deterre, C.; Deviveiros, P. O.; Dewhurst, A.; Dhaliwal, S.; Di Ciaccio, A.; Di Ciaccio, L.; Di Domenico, A.; Di Donato, C.; Di Girolamo, A.; Di Girolamo, B.; Di Mattia, A.; Di Micco, B.; Di Nardo, R.; Di Simone, A.; Di Sipio, R.; Di Valentino, D.; Diaz, M. A.; Diehl, E. B.; Dietrich, J.; Dietzsch, T. A.; Diglio, S.; Dimitrievska, A.; Dingfelder, J.; Dionisi, C.; Dita, P.; Dita, S.; Dittus, F.; Djama, F.; Djobava, T.; do Vale, M. A. B.; Do Valle Wemans, A.; Doan, T. K. O.; Dobos, D.; Dobson, E.; Doglioni, C.; Doherty, T.; Dohmae, T.; Dolejsi, J.; Dolezal, Z.; Dolgoshein, B. A.; Donadelli, M.; Donati, S.; Dondero, P.; Donini, J.; Dopke, J.; Doria, A.; Dova, M. T.; Doyle, A. T.; Dris, M.; Dubbert, J.; Dube, S.; Dubreuil, E.; Duchovni, E.; Duckeck, G.; Ducu, O. A.; Duda, D.; Dudarev, A.; Dudziak, F.; Duflot, L.; Duguid, L.; Dührssen, M.; Dunford, M.; Yildiz, H. Duran; Düren, M.; Durglishvili, A.; Dwuznik, M.; Dyndal, M.; Ebke, J.; Edson, W.; Edwards, N. C.; Ehrenfeld, W.; Eifert, T.; Eigen, G.; Einsweiler, K.; Ekelof, T.; El Kacimi, M.; Ellert, M.; Elles, S.; Ellinghaus, F.; Ellis, N.; Elmsheuser, J.; Elsing, M.; Emeliyanov, D.; Enari, Y.; Endner, O. C.; Endo, M.; Engelmann, R.; Erdmann, J.; Ereditato, A.; Eriksson, D.; Ernis, G.; Ernst, J.; Ernst, M.; Ernwein, J.; Errede, D.; Errede, S.; Ertel, E.; Escalier, M.; Esch, H.; Escobar, C.; Esposito, B.; Etienvre, A. I.; Etzion, E.; Evans, H.; Fabbri, L.; Facini, G.; Fakhrutdinov, R. M.; Falciano, S.; Faltova, J.; Fang, Y.; Fanti, M.; Farbin, A.; Farilla, A.; Farooque, T.; Farrell, S.; Farrington, S. M.; Farthouat, P.; Fassi, F.; Fassnacht, P.; Fassouliotis, D.; Favareto, A.; Fayard, L.; Federic, P.; Fedin, O. L.; Fedorko, W.; Fehling-Kaschek, M.; Feigl, S.; Feligioni, L.; Feng, C.; Feng, E. J.; Feng, H.; Fenyuk, A. B.; Perez, S. Fernandez; Fernando, W.; Ferrag, S.; Ferrando, J.; Ferrara, V.; Ferrari, A.; Ferrari, P.; Ferrari, R.; Ferreira de Lima, D. E.; Ferrer, A.; Ferrere, D.; Ferretti, C.; Parodi, A. Ferretto; Fiascaris, M.; Fiedler, F.; Filipčič, A.; Filipuzzi, M.; Filthaut, F.; Fincke-Keeler, M.; Finelli, K. D.; Fiolhais, M. C. N.; Fiorini, L.; Firan, A.; Fischer, J.; Fisher, M. J.; Fisher, W. C.; Fitzgerald, E. A.; Flechl, M.; Fleck, I.; Fleischmann, P.; Fleischmann, S.; Fletcher, G. T.; Fletcher, G.; Flick, T.; Floderus, A.; Castillo, L. R. Flores; Bustos, A. C. Florez; Flowerdew, M. J.; Formica, A.; Forti, A.; Fortin, D.; Fournier, D.; Fox, H.; Fracchia, S.; Francavilla, P.; Franchini, M.; Franchino, S.; Francis, D.; Franklin, M.; Franz, S.; Fraternali, M.; French, S. T.; Friedrich, C.; Friedrich, F.; Froidevaux, D.; Frost, J. A.; Fukunaga, C.; Torregrosa, E. Fullana; Fulsom, B. G.; Fuster, J.; Gabaldon, C.; Gabizon, O.; Gabrielli, A.; Gabrielli, A.; Gadatsch, S.; Gadomski, S.; Gagliardi, G.; Gagnon, P.; Galea, C.; Galhardo, B.; Gallas, E. J.; Gallo, V.; Gallop, B. J.; Gallus, P.; Galster, G.; Gan, K. K.; Gandrajula, R. P.; Gao, J.; Gao, Y. S.; Walls, F. M. Garay; Garberson, F.; García, C.; Navarro, J. E. García; Garcia-Sciveres, M.; Gardner, R. W.; Garelli, N.; Garonne, V.; Gatti, C.; Gaudio, G.; Gaur, B.; Gauthier, L.; Gauzzi, P.; Gavrilenko, I. L.; Gay, C.; Gaycken, G.; Gazis, E. N.; Ge, P.; Gecse, Z.; Gee, C. N. P.; Geerts, D. A. A.; Geich-Gimbel, Ch.; Gellerstedt, K.; Gemme, C.; Gemmell, A.; Genest, M. H.; Gentile, S.; George, M.; George, S.; Gerbaudo, D.; Gershon, A.; Ghazlane, H.; Ghodbane, N.; Giacobbe, B.; Giagu, S.; Giangiobbe, V.; Giannetti, P.; Gianotti, F.; Gibbard, B.; Gibson, S. M.; Gilchriese, M.; Gillam, T. P. S.; Gillberg, D.; Gingrich, D. M.; Giokaris, N.; Giordani, M. P.; Giordano, R.; Giorgi, F. M.; Giraud, P. F.; Giugni, D.; Giuliani, C.; Giulini, M.; Gjelsten, B. K.; Gkialas, I.; Gladilin, L. K.; Glasman, C.; Glatzer, J.; Glaysher, P. C. F.; Glazov, A.; Glonti, G. L.; Goblirsch-Kolb, M.; Goddard, J. R.; Godfrey, J.; Godlewski, J.; Goeringer, C.; Goldfarb, S.; Golling, T.; Golubkov, D.; Gomes, A.; Fajardo, L. S. Gomez; Gonçalo, R.; Da Costa, J. Goncalves Pinto Firmino; Gonella, L.; de la Hoz, S. González; Parra, G. Gonzalez; Silva, M. L. Gonzalez; Gonzalez-Sevilla, S.; Goossens, L.; Gorbounov, P. A.; Gordon, H. A.; Gorelov, I.; Gorini, B.; Gorini, E.; Gorišek, A.; Gornicki, E.; Goshaw, A. T.; Gössling, C.; Gostkin, M. I.; Gouighri, M.; Goujdami, D.; Goulette, M. P.; Goussiou, A. G.; Goy, C.; Gozpinar, S.; Grabas, H. M. X.; Graber, L.; Grabowska-Bold, I.; Grafström, P.; Grahn, K.-J.; Gramling, J.; Gramstad, E.; Grancagnolo, F.; Grancagnolo, S.; Grassi, V.; Gratchev, V.; Gray, H. M.; Graziani, E.; Grebenyuk, O. G.; Greenwood, Z. D.; Gregersen, K.; Gregor, I. M.; Grenier, P.; Griffiths, J.; Grillo, A. A.; Grimm, K.; Grinstein, S.; Gris, Ph.; Grishkevich, Y. V.; Grivaz, J.-F.; Grohs, J. P.; Grohsjean, A.; Gross, E.; Grosse-Knetter, J.; Grossi, G. C.; Groth-Jensen, J.; Grout, Z. J.; Grybel, K.; Guan, L.; Guescini, F.; Guest, D.; Gueta, O.; Guicheney, C.; Guido, E.; Guillemin, T.; Guindon, S.; Gul, U.; Gumpert, C.; Gunther, J.; Guo, J.; Gupta, S.; Gutierrez, P.; Ortiz, N. G. Gutierrez; Gutschow, C.; Guttman, N.; Guyot, C.; Gwenlan, C.; Gwilliam, C. B.; Haas, A.; Haber, C.; Hadavand, H. K.; Haddad, N.; Haefner, P.; Hageböck, S.; Hajduk, Z.; Hakobyan, H.; Haleem, M.; Hall, D.; Halladjian, G.; Hamacher, K.; Hamal, P.; Hamano, K.; Hamer, M.; Hamilton, A.; Hamilton, S.; Hamnett, P. G.; Han, L.; Hanagaki, K.; Hanawa, K.; Hance, M.; Hanke, P.; Hansen, J. B.; Hansen, J. D.; Hansen, P. H.; Hara, K.; Hard, A. S.; Harenberg, T.; Harkusha, S.; Harper, D.; Harrington, R. D.; Harris, O. M.; Harrison, P. F.; Hartjes, F.; Harvey, A.; Hasegawa, S.; Hasegawa, Y.; Hasib, A.; Hassani, S.; Haug, S.; Hauschild, M.; Hauser, R.; Havranek, M.; Hawkes, C. M.; Hawkings, R. J.; Hawkins, A. D.; Hayashi, T.; Hayden, D.; Hays, C. P.; Hayward, H. S.; Haywood, S. J.; Head, S. J.; Heck, T.; Hedberg, V.; Heelan, L.; Heim, S.; Heim, T.; Heinemann, B.; Heinrich, L.; Heisterkamp, S.; Hejbal, J.; Helary, L.; Heller, C.; Heller, M.; Hellman, S.; Hellmich, D.; Helsens, C.; Henderson, J.; Henderson, R. C. W.; Hengler, C.; Henrichs, A.; Correia, A. M. Henriques; Henrot-Versille, S.; Hensel, C.; Herbert, G. H.; Jiménez, Y. Hernández; Herrberg-Schubert, R.; Herten, G.; Hertenberger, R.; Hervas, L.; Hesketh, G. G.; Hessey, N. P.; Hickling, R.; Higón-Rodriguez, E.; Hill, J. C.; Hiller, K. H.; Hillert, S.; Hillier, S. J.; Hinchliffe, I.; Hines, E.; Hirose, M.; Hirschbuehl, D.; Hobbs, J.; Hod, N.; Hodgkinson, M. C.; Hodgson, P.; Hoecker, A.; Hoeferkamp, M. R.; Hoffman, J.; Hoffmann, D.; Hofmann, J. I.; Hohlfeld, M.; Holmes, T. R.; Hong, T. M.; van Huysduynen, L. Hooft; Hostachy, J.-Y.; Hou, S.; Hoummada, A.; Howard, J.; Howarth, J.; Hrabovsky, M.; Hristova, I.; Hrivnac, J.; Hryn'ova, T.; Hsu, P. J.; Hsu, S.-C.; Hu, D.; Hu, X.; Huang, Y.; Hubacek, Z.; Hubaut, F.; Huegging, F.; Huffman, T. B.; Hughes, E. W.; Hughes, G.; Huhtinen, M.; Hülsing, T. A.; Hurwitz, M.; Huseynov, N.; Huston, J.; Huth, J.; Iacobucci, G.; Iakovidis, G.; Ibragimov, I.; Iconomidou-Fayard, L.; Ideal, E.; Iengo, P.; Igonkina, O.; Iizawa, T.; Ikegami, Y.; Ikematsu, K.; Ikeno, M.; Iliadis, D.; Ilic, N.; Inamaru, Y.; Ince, T.; Ioannou, P.; Iodice, M.; Iordanidou, K.; Ippolito, V.; Quiles, A. Irles; Isaksson, C.; Ishino, M.; Ishitsuka, M.; Ishmukhametov, R.; Issever, C.; Istin, S.; Ponce, J. M. Iturbe; Ivashin, A. V.; Iwanski, W.; Iwasaki, H.; Izen, J. M.; Izzo, V.; Jackson, B.; Jackson, J. N.; Jackson, M.; Jackson, P.; Jaekel, M. R.; Jain, V.; Jakobs, K.; Jakobsen, S.; Jakoubek, T.; Jakubek, J.; Jamin, D. O.; Jana, D. K.; Jansen, E.; Jansen, H.; Janssen, J.; Janus, M.; Jarlskog, G.; Javůrek, T.; Jeanty, L.; Jeng, G.-Y.; Jennens, D.; Jenni, P.; Jentzsch, J.; Jeske, C.; Jézéquel, S.; Ji, H.; Ji, W.; Jia, J.; Jiang, Y.; Belenguer, M. Jimenez; Jin, S.; Jinaru, A.; Jinnouchi, O.; Joergensen, M. D.; Johansson, K. E.; Johansson, P.; Johns, K. A.; Jon-And, K.; Jones, G.; Jones, R. W. L.; Jones, T. J.; Jongmanns, J.; Jorge, P. M.; Joshi, K. D.; Jovicevic, J.; Ju, X.; Jung, C. A.; Jungst, R. M.; Jussel, P.; Rozas, A. Juste; Kaci, M.; Kaczmarska, A.; Kado, M.; Kagan, H.; Kagan, M.; Kajomovitz, E.; Kama, S.; Kanaya, N.; Kaneda, M.; Kaneti, S.; Kanno, T.; Kantserov, V. A.; Kanzaki, J.; Kaplan, B.; Kapliy, A.; Kar, D.; Karakostas, K.; Karastathis, N.; Karnevskiy, M.; Karpov, S. N.; Karthik, K.; Kartvelishvili, V.; Karyukhin, A. N.; Kashif, L.; Kasieczka, G.; Kass, R. D.; Kastanas, A.; Kataoka, Y.; Katre, A.; Katzy, J.; Kaushik, V.; Kawagoe, K.; Kawamoto, T.; Kawamura, G.; Kazama, S.; Kazanin, V. F.; Kazarinov, M. Y.; Keeler, R.; Kehoe, R.; Keil, M.; Keller, J. S.; Keoshkerian, H.; Kepka, O.; Kerševan, B. P.; Kersten, S.; Kessoku, K.; Keung, J.; Khalil-zada, F.; Khandanyan, H.; Khanov, A.; Khodinov, A.; Khomich, A.; Khoo, T. J.; Khoriauli, G.; Khoroshilov, A.; Khovanskiy, V.; Khramov, E.; Khubua, J.; Kim, H. Y.; Kim, H.; Kim, S. 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T.; Shapiro, M.; Shatalov, P. B.; Shaw, K.; Sherwood, P.; Shimizu, S.; Shimmin, C. O.; Shimojima, M.; Shiyakova, M.; Shmeleva, A.; Shochet, M. J.; Short, D.; Shrestha, S.; Shulga, E.; Shupe, M. A.; Shushkevich, S.; Sicho, P.; Sidorov, D.; Sidoti, A.; Siegert, F.; Sijacki, Dj.; Silbert, O.; Silva, J.; Silver, Y.; Silverstein, D.; Silverstein, S. B.; Simak, V.; Simard, O.; Simic, Lj.; Simion, S.; Simioni, E.; Simmons, B.; Simoniello, R.; Simonyan, M.; Sinervo, P.; Sinev, N. B.; Sipica, V.; Siragusa, G.; Sircar, A.; Sisakyan, A. N.; Sivoklokov, S. Yu.; Sjölin, J.; Sjursen, T. B.; Skinnari, L. A.; Skottowe, H. P.; Skovpen, K. Yu.; Skubic, P.; Slater, M.; Slavicek, T.; Sliwa, K.; Smakhtin, V.; Smart, B. H.; Smestad, L.; Smirnov, S. Yu.; Smirnov, Y.; Smirnova, L. N.; Smirnova, O.; Smith, K. M.; Smizanska, M.; Smolek, K.; Snesarev, A. A.; Snidero, G.; Snyder, S.; Sobie, R.; Socher, F.; Soffer, A.; Soh, D. A.; Solans, C. A.; Solar, M.; Solc, J.; Soldatov, E. Yu.; Soldevila, U.; Camillocci, E. Solfaroli; Solodkov, A. A.; Solovyanov, O. V.; Solovyev, V.; Sommer, P.; Song, H. Y.; Soni, N.; Sood, A.; Sopko, B.; Sopko, V.; Sorin, V.; Sosebee, M.; Soualah, R.; Soueid, P.; Soukharev, A. M.; South, D.; Spagnolo, S.; Spanò, F.; Spearman, W. R.; Spighi, R.; Spigo, G.; Spousta, M.; Spreitzer, T.; Spurlock, B.; St. Denis, R. D.; Staerz, S.; Stahlman, J.; Stamen, R.; Stanecka, E.; Stanek, R. W.; Stanescu, C.; Stanescu-Bellu, M.; Stanitzki, M. M.; Stapnes, S.; Starchenko, E. A.; Stark, J.; Staroba, P.; Starovoitov, P.; Staszewski, R.; Stavina, P.; Steele, G.; Steinberg, P.; Stelzer, B.; Stelzer, H. J.; Stelzer-Chilton, O.; Stenzel, H.; Stern, S.; Stewart, G. A.; Stillings, J. A.; Stockton, M. C.; Stoebe, M.; Stoerig, K.; Stoicea, G.; Stolte, P.; Stonjek, S.; Stradling, A. R.; Straessner, A.; Strandberg, J.; Strandberg, S.; Strandlie, A.; Strauss, E.; Strauss, M.; Strizenec, P.; Ströhmer, R.; Strom, D. M.; Stroynowski, R.; Stucci, S. A.; Stugu, B.; Styles, N. A.; Su, D.; Su, J.; Subramania, H. S.; Subramaniam, R.; Succurro, A.; Sugaya, Y.; Suhr, C.; Suk, M.; Sulin, V. V.; Sultansoy, S.; Sumida, T.; Sun, X.; Sundermann, J. E.; Suruliz, K.; Susinno, G.; Sutton, M. R.; Suzuki, Y.; Svatos, M.; Swedish, S.; Swiatlowski, M.; Sykora, I.; Sykora, T.; Ta, D.; Tackmann, K.; Taenzer, J.; Taffard, A.; Tafirout, R.; Taiblum, N.; Takahashi, Y.; Takai, H.; Takashima, R.; Takeda, H.; Takeshita, T.; Takubo, Y.; Talby, M.; Talyshev, A. A.; Tam, J. Y. C.; Tamsett, M. C.; Tan, K. G.; Tanaka, J.; Tanaka, R.; Tanaka, S.; Tanaka, S.; Tanasijczuk, A. J.; Tani, K.; Tannoury, N.; Tapprogge, S.; Tarem, S.; Tarrade, F.; Tartarelli, G. F.; Tas, P.; Tasevsky, M.; Tashiro, T.; Tassi, E.; Delgado, A. Tavares; Tayalati, Y.; Taylor, C.; Taylor, F. E.; Taylor, G. N.; Taylor, W.; Teischinger, F. A.; Castanheira, M. Teixeira Dias; Teixeira-Dias, P.; Temming, K. K.; Kate, H. Ten; Teng, P. K.; Terada, S.; Terashi, K.; Terron, J.; Terzo, S.; Testa, M.; Teuscher, R. J.; Therhaag, J.; Theveneaux-Pelzer, T.; Thoma, S.; Thomas, J. P.; Thomas-Wilsker, J.; Thompson, E. N.; Thompson, P. D.; Thompson, P. D.; Thompson, A. S.; Thomsen, L. A.; Thomson, E.; Thomson, M.; Thong, W. M.; Thun, R. P.; Tian, F.; Tibbetts, M. J.; Tikhomirov, V. O.; Tikhonov, Yu. A.; Timoshenko, S.; Tiouchichine, E.; Tipton, P.; Tisserant, S.; Todorov, T.; Todorova-Nova, S.; Toggerson, B.; Tojo, J.; Tokár, S.; Tokushuku, K.; Tollefson, K.; Tomlinson, L.; Tomoto, M.; Tompkins, L.; Toms, K.; Topilin, N. D.; Torrence, E.; Torres, H.; Pastor, E. Torró; Toth, J.; Touchard, F.; Tovey, D. R.; Tran, H. L.; Trefzger, T.; Tremblet, L.; Tricoli, A.; Trigger, I. M.; Trincaz-Duvoid, S.; Tripiana, M. F.; Triplett, N.; Trischuk, W.; Trocmé, B.; Troncon, C.; Trottier-McDonald, M.; Trovatelli, M.; True, P.; Trzebinski, M.; Trzupek, A.; Tsarouchas, C.; Tseng, J. C.-L.; Tsiareshka, P. V.; Tsionou, D.; Tsipolitis, G.; Tsirintanis, N.; Tsiskaridze, S.; Tsiskaridze, V.; Tskhadadze, E. G.; Tsukerman, I. I.; Tsulaia, V.; Tsuno, S.; Tsybychev, D.; Tua, A.; Tudorache, A.; Tudorache, V.; Tuna, A. N.; Tupputi, S. A.; Turchikhin, S.; Turecek, D.; Cakir, I. Turk; Turra, R.; Tuts, P. M.; Tykhonov, A.; Tylmad, M.; Tyndel, M.; Uchida, K.; Ueda, I.; Ueno, R.; Ughetto, M.; Ugland, M.; Uhlenbrock, M.; Ukegawa, F.; Unal, G.; Undrus, A.; Unel, G.; Ungaro, F. C.; Unno, Y.; Urbaniec, D.; Urquijo, P.; Usai, G.; Usanova, A.; Vacavant, L.; Vacek, V.; Vachon, B.; Valencic, N.; Valentinetti, S.; Valero, A.; Valery, L.; Valkar, S.; Gallego, E. Valladolid; Vallecorsa, S.; Ferrer, J. A. Valls; Van Der Deijl, P. C.; van der Geer, R.; van der Graaf, H.; Van Der Leeuw, R.; van der Ster, D.; Eldik, N. van; van Gemmeren, P.; Van Nieuwkoop, J.; van Vulpen, I.; van Woerden, M. C.; Vanadia, M.; Vandelli, W.; Vaniachine, A.; Vankov, P.; Vannucci, F.; Vardanyan, G.; Vari, R.; Varnes, E. W.; Varol, T.; Varouchas, D.; Vartapetian, A.; Varvell, K. E.; Vazeille, F.; Schroeder, T. Vazquez; Veatch, J.; Veloso, F.; Veneziano, S.; Ventura, A.; Ventura, D.; Venturi, M.; Venturi, N.; Venturini, A.; Vercesi, V.; Verducci, M.; Verkerke, W.; Vermeulen, J. C.; Vest, A.; Vetterli, M. C.; Viazlo, O.; Vichou, I.; Vickey, T.; Boeriu, O. E. Vickey; Viehhauser, G. H. A.; Viel, S.; Vigne, R.; Villa, M.; Perez, M. Villaplana; Vilucchi, E.; Vincter, M. G.; Vinogradov, V. B.; Virzi, J.; Vitells, O.; Vivarelli, I.; Vaque, F. Vives; Vlachos, S.; Vladoiu, D.; Vlasak, M.; Vogel, A.; Vokac, P.; Volpi, G.; Volpi, M.; von der Schmitt, H.; Radziewski, H. von; von Toerne, E.; Vorobel, V.; Vos, M.; Voss, R.; Vossebeld, J. H.; Vranjes, N.; Milosavljevic, M. Vranjes; Vrba, V.; Vreeswijk, M.; Anh, T. Vu; Vuillermet, R.; Vukotic, I.; Vykydal, Z.; Wagner, P.; Wagner, W.; Wahrmund, S.; Wakabayashi, J.; Walder, J.; Walker, R.; Walkowiak, W.; Wall, R.; Waller, P.; Walsh, B.; Wang, C.; Wang, C.; Wang, F.; Wang, H.; Wang, H.; Wang, J.; Wang, J.; Wang, K.; Wang, R.; Wang, S. M.; Wang, T.; Wang, X.; Warburton, A.; Ward, C. P.; Wardrope, D. R.; Warsinsky, M.; Washbrook, A.; Wasicki, C.; Watanabe, I.; Watkins, P. M.; Watson, A. T.; Watson, I. J.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, B. M.; Webb, S.; Weber, M. S.; Weber, S. W.; Webster, J. S.; Weidberg, A. R.; Weigell, P.; Weinert, B.; Weingarten, J.; Weiser, C.; Weits, H.; Wells, P. S.; Wenaus, T.; Wendland, D.; Weng, Z.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Wessels, M.; Wetter, J.; Whalen, K.; White, A.; White, M. J.; White, R.; White, S.; Whiteson, D.; Wicke, D.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik-Fuchs, L. A. M.; Wijeratne, P. A.; Wildauer, A.; Wildt, M. A.; Wilkens, H. G.; Will, J. Z.; Williams, H. H.; Williams, S.; Willis, C.; Willocq, S.; Wilson, A.; Wilson, J. A.; Wingerter-Seez, I.; Winkelmann, S.; Winklmeier, F.; Wittgen, M.; Wittig, T.; Wittkowski, J.; Wollstadt, S. J.; Wolter, M. W.; Wolters, H.; Wosiek, B. K.; Wotschack, J.; Woudstra, M. J.; Wozniak, K. W.; Wright, M.; Wu, S. L.; Wu, X.; Wu, Y.; Wulf, E.; Wyatt, T. R.; Wynne, B. M.; Xella, S.; Xiao, M.; Xu, D.; Xu, L.; Yabsley, B.; Yacoob, S.; Yamada, M.; Yamaguchi, H.; Yamaguchi, Y.; Yamamoto, A.; Yamamoto, K.; Yamamoto, S.; Yamamura, T.; Yamanaka, T.; Yamauchi, K.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, H.; Yang, U. K.; Yang, Y.; Yanush, S.; Yao, L.; Yao, W.-M.; Yasu, Y.; Yatsenko, E.; Wong, K. H. Yau; Ye, J.; Ye, S.; Yen, A. L.; Yildirim, E.; Yilmaz, M.; Yoosoofmiya, R.; Yorita, K.; Yoshida, R.; Yoshihara, K.; Young, C.; Young, C. J. S.; Youssef, S.; Yu, D. R.; Yu, J.; Yu, J. M.; Yu, J.; Yuan, L.; Yurkewicz, A.; Zabinski, B.; Zaidan, R.; Zaitsev, A. M.; Zaman, A.; Zambito, S.; Zanello, L.; Zanzi, D.; Zaytsev, A.; Zeitnitz, C.; Zeman, M.; Zemla, A.; Zengel, K.; Zenin, O.; Ženiš, T.; Zerwas, D.; della Porta, G. Zevi; Zhang, D.; Zhang, F.; Zhang, H.; Zhang, J.; Zhang, L.; Zhang, X.; Zhang, Z.; Zhao, Z.; Zhemchugov, A.; Zhong, J.; Zhou, B.; Zhou, L.; Zhou, N.; Zhu, C. G.; Zhu, H.; Zhu, J.; Zhu, Y.; Zhuang, X.; Zibell, A.; Zieminska, D.; Zimine, N. I.; Zimmermann, C.; Zimmermann, R.; Zimmermann, S.; Zimmermann, S.; Zinonos, Z.; Ziolkowski, M.; Zitoun, R.; Zobernig, G.; Zoccoli, A.; zur Nedden, M.; Zurzolo, G.; Zutshi, V.; Zwalinski, L.
2014-08-01
Distributions sensitive to the underlying event in QCD jet events have been measured with the ATLAS detector at the LHC, based on of proton-proton collision data collected at a centre-of-mass energy of 7 . Charged-particle mean and densities of all-particle and charged-particle multiplicity and have been measured in regions azimuthally transverse to the hardest jet in each event. These are presented both as one-dimensional distributions and with their mean values as functions of the leading-jet transverse momentum from 20 to 800 . The correlation of charged-particle mean with charged-particle multiplicity is also studied, and the densities include the forward rapidity region; these features provide extra data constraints for Monte Carlo modelling of colour reconnection and beam-remnant effects respectively. For the first time, underlying event observables have been computed separately for inclusive jet and exclusive dijet event selections, allowing more detailed study of the interplay of multiple partonic scattering and QCD radiation contributions to the underlying event. Comparisons to the predictions of different Monte Carlo models show a need for further model tuning, but the standard approach is found to generally reproduce the features of the underlying event in both types of event selection.
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33 CFR 100.30 - Approval required for holding event.
Code of Federal Regulations, 2013 CFR
2013-07-01
... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...
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33 CFR 100.30 - Approval required for holding event.
Code of Federal Regulations, 2012 CFR
2012-07-01
... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...
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33 CFR 100.30 - Approval required for holding event.
Code of Federal Regulations, 2011 CFR
2011-07-01
... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...
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33 CFR 100.30 - Approval required for holding event.
Code of Federal Regulations, 2014 CFR
2014-07-01
... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...
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Cornelissen, Scarlett
2012-06-01
South Africa's hosting of the 2010 FIFA World Cup saw a large number of public demonstrations, strikes and other forms of civic campaigning. World Cup activism was both preceded and followed by extensive and intensifying public unrest and industrial action that in the period before the tournament, threatened to derail the event. This paper assesses the motivations, forms and implications of the activism during South Africa's staging of the FIFA finals and interprets them against the larger context of shifting state-society relations in the country. There are two purposes to the analysis. First, to explore the underlying internal social forces that gave shape to the protests at the time, and the possible influence of the exogenous politics of mega-event social mobilization. Second, the implications and outcomes of these dynamics for longer term socio-political processes in the country are considered. The activism displayed many of the features of the politics of contestation of sport mega-events today. Importantly, however, the activism stemmed from a particular systemic dynamic and reflected changing relations in the post-apartheid political community. Therefore, while the World Cup was used as a strategic opportunity by many advocacy groups, it was one that rather fleetingly and ambivalently presented an additional platform to such groups in an otherwise on-going set of political battles. Rather than a strong case study of sport's transformative capacity, the civic campaigning during South Africa's World Cup demonstrates the way a sport mega-event can be used as a strategic entry point by civil society groups in their engagement with the state, although this can occur with greater or lesser success. © London School of Economics and Political Science 2012.
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Shelly, David R.; Ellsworth, William L.; Hill, David P.
2016-01-01
An extended earthquake swarm occurred beneath southeastern Long Valley Caldera between May and November 2014, culminating in three magnitude 3.5 earthquakes and 1145 cataloged events on 26 September alone. The swarm produced the most prolific seismicity in the caldera since a major unrest episode in 1997-1998. To gain insight into the physics controlling swarm evolution, we used large-scale cross-correlation between waveforms of cataloged earthquakes and continuous data, producing precise locations for 8494 events, more than 2.5 times the routine catalog. We also estimated magnitudes for 18,634 events (~5.5 times the routine catalog), using a principal component fit to measure waveform amplitudes relative to cataloged events. This expanded and relocated catalog reveals multiple episodes of pronounced hypocenter expansion and migration on a collection of neighboring faults. Given the rapid migration and alignment of hypocenters on narrow faults, we infer that activity was initiated and sustained by an evolving fluid pressure transient with a low-viscosity fluid, likely composed primarily of water and CO2 exsolved from underlying magma. Although both updip and downdip migration were observed within the swarm, downdip activity ceased shortly after activation, while updip activity persisted for weeks at moderate levels. Strongly migrating, single-fault episodes within the larger swarm exhibited a higher proportion of larger earthquakes (lower Gutenberg-Richter b value), which may have been facilitated by fluid pressure confined in two dimensions within the fault zone. In contrast, the later swarm activity occurred on an increasingly diffuse collection of smaller faults, with a much higher b value.
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The Electrical Network of Maize Root Apex is Gravity Dependent
Masi, Elisa; Ciszak, Marzena; Comparini, Diego; Monetti, Emanuela; Pandolfi, Camilla; Azzarello, Elisa; Mugnai, Sergio; Baluška, Frantisek; Mancuso, Stefano
2015-01-01
Investigations carried out on maize roots under microgravity and hypergravity revealed that gravity conditions have strong effects on the network of plant electrical activity. Both the duration of action potentials (APs) and their propagation velocities were significantly affected by gravity. Similarly to what was reported for animals, increased gravity forces speed-up APs and enhance synchronized electrical events also in plants. The root apex transition zone emerges as the most active, as well as the most sensitive, root region in this respect. PMID:25588706
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The electrical network of maize root apex is gravity dependent.
Masi, Elisa; Ciszak, Marzena; Comparini, Diego; Monetti, Emanuela; Pandolfi, Camilla; Azzarello, Elisa; Mugnai, Sergio; Baluška, Frantisek; Mancuso, Stefano
2015-01-15
Investigations carried out on maize roots under microgravity and hypergravity revealed that gravity conditions have strong effects on the network of plant electrical activity. Both the duration of action potentials (APs) and their propagation velocities were significantly affected by gravity. Similarly to what was reported for animals, increased gravity forces speed-up APs and enhance synchronized electrical events also in plants. The root apex transition zone emerges as the most active, as well as the most sensitive, root region in this respect.
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Verbalization and imagery in the process of formation of operator labor skills
NASA Technical Reports Server (NTRS)
Mistyuk, V. V.
1975-01-01
Sensorimotor control tests show that mastering operational skills occurs under conditions that stimulate the operator to independent active analysis and summarization of current information with the goal of clarifying the signs and the integral images that are a model of the situation. Goal directed determination of such an image requires inner and external speech, activates and improves the thinking of the operator, accelerates the training process, increases its effectiveness, and enables the formation of strategies in anticipating the course of events.
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26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.
Code of Federal Regulations, 2014 CFR
2014-04-01
... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...
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26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.
Code of Federal Regulations, 2013 CFR
2013-04-01
... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...
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26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.
Code of Federal Regulations, 2011 CFR
2011-04-01
... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...
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26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.
Code of Federal Regulations, 2010 CFR
2010-04-01
... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...
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26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.
Code of Federal Regulations, 2012 CFR
2012-04-01
... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...
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The Neural Representations Underlying Human Episodic Memory.
Xue, Gui
2018-06-01
A fundamental question of human episodic memory concerns the cognitive and neural representations and processes that give rise to the neural signals of memory. By integrating behavioral tests, formal computational models, and neural measures of brain activity patterns, recent studies suggest that memory signals not only depend on the neural processes and representations during encoding and retrieval, but also on the interaction between encoding and retrieval (e.g., transfer-appropriate processing), as well as on the interaction between the tested events and all other events in the episodic memory space (e.g., global matching). In addition, memory signals are also influenced by the compatibility of the event with the existing long-term knowledge (e.g., schema matching). These studies highlight the interactive nature of human episodic memory. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Agaku, Israel T; Odani, Satomi; Sturgis, Stephanie; Harless, Charles; Glover-Kudon, Rebecca
2016-08-19
Smokeless tobacco has been actively promoted by tobacco companies using endorsements by major sport figures, and research indicates that tobacco advertising can lead to youth initiation of tobacco use (1,2). Television and radio advertisements for cigarettes and smokeless tobacco have been prohibited since 1969,* and the 1998 Master Settlement Agreement(†) further prohibited tobacco companies from targeting youths with tobacco product advertisements in specified areas. In 2010, the Food and Drug Administration (FDA), under authority of the 2009 Family Smoking Prevention and Tobacco Control Act (FSPTCA), prohibited tobacco-brand sponsorship (i.e., sponsorship of sports and entertainment events or other social or cultural events using the tobacco brand name or anything identifiable with any brand of cigarettes or smokeless tobacco).(§) However, corporate-name tobacco sponsorship (i.e., sponsorship using the name of the corporation that manufactures regulated tobacco products) is still permitted under certain conditions.(¶) To monitor tobacco advertising and promotional activities in sports in the United States, CDC analyzed trends in sports-related marketing expenditures for cigarettes and smokeless tobacco during 1992-2013 using data from the Federal Trade Commission (FTC). During 1992-2013, sports-related marketing expenditures, adjusted by the consumer price index to constant 2013 dollars, decreased significantly for both cigarettes (from $136 million in 1992 to $0 in 2013) and smokeless tobacco (from $34.8 million in 1992 to $2.1 million in 2013). During 2010-2013, after the prohibition of tobacco-brand sponsorship in sports under the FSPTCA, cigarette manufacturers reported no spending (i.e., $0) on sports-related advertising and promotional activities; in contrast, smokeless tobacco manufacturers reported expenditures of $16.3 million on advertising and promoting smokeless tobacco in sports during 2010-2013. These findings indicate that despite prohibitions on brand sponsorship, smokeless tobacco products continue to be marketed in sports in the United States, potentially through other indirect channels such as corporate-name sponsorship. Enhanced measures are warranted to restrict youth-oriented tobacco marketing and promotional activities that could lead to tobacco initiation and use among children and adolescents (2). Reducing tobacco industry promotion through sponsorship of public and private events is an evidence-based strategy for preventing youth initiation of tobacco use (3). In addition, other proven interventions (e.g., tobacco price increases, anti-tobacco mass media campaigns, tobacco-free policies inclusive of smokeless tobacco, and barrier-free access to cessation services), could help reduce smokeless tobacco use in the United States (1).
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Zimmerman, Gabriel; Njunting, Marleisje; Ivens, Sebastian; Tolner, Else A; Tolner, Elsa; Behrens, Christoph J; Gross, Miriam; Soreq, Hermona; Heinemann, Uwe; Friedman, Alon
2008-02-01
The entorhinal cortex (EC) plays an important role in temporal lobe epilepsy. Under normal conditions, the enriched cholinergic innervation of the EC modulates local synchronized oscillatory activity; however, its role in epilepsy is unknown. Enhanced neuronal activation has been shown to induce transcriptional changes of key cholinergic genes and thus alter cholinergic responses. To examine cholinergic modulations in epileptic tissue we studied molecular and electrophysiological cholinergic responses in the EC of chronically epileptic rats following exposure to pilocarpine or kainic acid. We confirmed that while the total activity of the acetylcholine (ACh)-hydrolysing enzyme, acetylcholinesterase (AChE) was not altered, epileptic rats showed alternative splicing of AChE pre-mRNA transcripts, accompanied by a shift from membrane-bound AChE tetramers to soluble monomers. This was associated with increased sensitivity to ACh application: thus, in control rats, ACh (10-100 microm) induced slow (< 1Hz), periodic events confined to the EC; however, in epileptic rats, ACh evoked seconds-long seizure-like events with initial appearance in the EC, and frequent propagation to neighbouring cortical regions. ACh-induced seizure-like events could be completely blocked by the non-specific muscarinic antagonist, atropine, and were partially blocked by the muscarinic-1 receptor antagonist, pirenzepine; but were not affected by the non-specific nicotinic antagonist, mecamylamine. Epileptic rats presented reduced transcript levels of muscarinic receptors with no evidence of mRNA editing or altered mRNA levels for nicotinic ACh receptors. Our findings suggest that altered cholinergic modulation may initiate seizure events in the epileptic temporal cortex.
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Bor, Serhat; Valytova, Elen; Yildirim, Esra; Vardar, Rukiye
2014-01-01
Background The role of sexual activity on gastroesophageal reflux disease (GERD) is an under-recognized concern of patients, and one rarely assessed by physicians. Objective The objective of this article is to determine the influence of sexual activity on the intraesophageal acid exposure and acid reflux events in GERD patients. Methods Twenty-one patients with the diagnosis of GERD were prospectively enrolled. Intraesophageal pH monitoring was recorded for 48 hours with a Bravo capsule. All patients were instructed to have sexual intercourse or abstain in a random order two hours after the same refluxogenic dinner within two consecutive nights. Patients were requested to have sex in the standard “missionary position” and women were warned to avoid abdominal compression. The patients completed a diary reporting the time of the sexual intercourse and GERD symptoms. The percentage of reflux time and acid reflux events were compared in two ways: within 30 and 60 minutes prior to and after sexual intercourse on the day of sexual intercourse and in the same time frame of the day without sexual intercourse. Results Fifteen of 21 GERD patients were analyzed. The percentage of reflux time and number of acid reflux events did not show a significant difference within the 30- and 60-minute periods prior to and after sexual intercourse on the day of sexual intercourse and on the day without sexual intercourse, as well. Conclusion Sexual activity does not predispose to increased intraesophageal acid exposure and acid reflux events. Larger studies are needed to confirm our findings in patients who define reflux symptoms during sexual intercourse. PMID:25452843
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NASA Astrophysics Data System (ADS)
Ishihara, Y.; Yamamoto, Y.; Arai, R.
2017-12-01
Recently slow or low frequency seismic and geodetic events are focused under recognition of important role in tectonic process. The most western region of Ryukyu trench, Yaeyama Islands, is very active area of these type events. It has semiannual-like slow slip (Heki et.al., 2008; Nishimura et.al.,2014) and very frequent shallow very low frequency earthquakes near trench zone (Ando et.al.,2012; Nakamura et.al.,2014). Arai et.al.(2016) identified clear reverse phase discontinuity along plate boundary by air-gun survey, suggesting existence of low velocity layer including fluid. The subducting fluid layer is considered to control slip characteristics. On the other hand, deep low frequency earthquake and tremor observed at south-western Honshu and Shikoku of Japan are not identified well due to lack of high-quality seismic network. A broadband seismic station(ISG/PS) of Pacific21 network is operating in last 20 years that locates on occurrence potential area of low frequency earthquake. We tried to review continuous broadband record, searching low frequency earthquakes. In pilot survey, we found three very low frequency seismic events which are dominant in less than 0.1Hz component and are not listed in earthquake catalogue. Source locates about 50km depth and at transition area between slow slip event and active area of general earthquake along plate boundary. To detect small and/or hidden very low frequency earthquake, we applied matched filter analysis to continuous three components waveform data using pre-reviewed seismogram as template signal. 12 events with high correlation are picked up in last 10 years. Most events have very similar waveform, which means characteristics of repeating deep very low frequency earthquake. The event history of very low frequency earthquake is not related with one of slow slip event in this region. In Yaeyama region, low frequency earthquake, general earthquake and slow slip event occur dividing in space and have apparent independent activity. Further 3D survey around plate boundary may take us important understanding of controlling feature of seismic and geodetic slip.
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Relating triggering processes in lab experiments with earthquakes.
NASA Astrophysics Data System (ADS)
Baro Urbea, J.; Davidsen, J.; Kwiatek, G.; Charalampidou, E. M.; Goebel, T.; Stanchits, S. A.; Vives, E.; Dresen, G.
2016-12-01
Statistical relations such as Gutenberg-Richter's, Omori-Utsu's and the productivity of aftershocks were first observed in seismology, but are also common to other physical phenomena exhibiting avalanche dynamics such as solar flares, rock fracture, structural phase transitions and even stock market transactions. All these examples exhibit spatio-temporal correlations that can be explained as triggering processes: Instead of being activated as a response to external driving or fluctuations, some events are consequence of previous activity. Although different plausible explanations have been suggested in each system, the ubiquity of such statistical laws remains unknown. However, the case of rock fracture may exhibit a physical connection with seismology. It has been suggested that some features of seismology have a microscopic origin and are reproducible over a vast range of scales. This hypothesis has motivated mechanical experiments to generate artificial catalogues of earthquakes at a laboratory scale -so called labquakes- and under controlled conditions. Microscopic fractures in lab tests release elastic waves that are recorded as ultrasonic (kHz-MHz) acoustic emission (AE) events by means of piezoelectric transducers. Here, we analyse the statistics of labquakes recorded during the failure of small samples of natural rocks and artificial porous materials under different controlled compression regimes. Temporal and spatio-temporal correlations are identified in certain cases. Specifically, we distinguish between the background and triggered events, revealing some differences in the statistical properties. We fit the data to statistical models of seismicity. As a particular case, we explore the branching process approach simplified in the Epidemic Type Aftershock Sequence (ETAS) model. We evaluate the empirical spatio-temporal kernel of the model and investigate the physical origins of triggering. Our analysis of the focal mechanisms implies that the occurrence of the empirical laws extends well beyond purely frictional sliding events, in contrast to what is often assumed.
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Nonspatial Sequence Coding in CA1 Neurons
Allen, Timothy A.; Salz, Daniel M.; McKenzie, Sam
2016-01-01
The hippocampus is critical to the memory for sequences of events, a defining feature of episodic memory. However, the fundamental neuronal mechanisms underlying this capacity remain elusive. While considerable research indicates hippocampal neurons can represent sequences of locations, direct evidence of coding for the memory of sequential relationships among nonspatial events remains lacking. To address this important issue, we recorded neural activity in CA1 as rats performed a hippocampus-dependent sequence-memory task. Briefly, the task involves the presentation of repeated sequences of odors at a single port and requires rats to identify each item as “in sequence” or “out of sequence”. We report that, while the animals' location and behavior remained constant, hippocampal activity differed depending on the temporal context of items—in this case, whether they were presented in or out of sequence. Some neurons showed this effect across items or sequence positions (general sequence cells), while others exhibited selectivity for specific conjunctions of item and sequence position information (conjunctive sequence cells) or for specific probe types (probe-specific sequence cells). We also found that the temporal context of individual trials could be accurately decoded from the activity of neuronal ensembles, that sequence coding at the single-cell and ensemble level was linked to sequence memory performance, and that slow-gamma oscillations (20–40 Hz) were more strongly modulated by temporal context and performance than theta oscillations (4–12 Hz). These findings provide compelling evidence that sequence coding extends beyond the domain of spatial trajectories and is thus a fundamental function of the hippocampus. SIGNIFICANCE STATEMENT The ability to remember the order of life events depends on the hippocampus, but the underlying neural mechanisms remain poorly understood. Here we addressed this issue by recording neural activity in hippocampal region CA1 while rats performed a nonspatial sequence memory task. We found that hippocampal neurons code for the temporal context of items (whether odors were presented in the correct or incorrect sequential position) and that this activity is linked with memory performance. The discovery of this novel form of temporal coding in hippocampal neurons advances our fundamental understanding of the neurobiology of episodic memory and will serve as a foundation for our cross-species, multitechnique approach aimed at elucidating the neural mechanisms underlying memory impairments in aging and dementia. PMID:26843637
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Structural and mechanistic insights into Mps1 kinase activation.
Wang, Wei; Yang, Yuting; Gao, Yuefeng; Xu, Quanbin; Wang, Feng; Zhu, Songcheng; Old, William; Resing, Katheryn; Ahn, Natalie; Lei, Ming; Liu, Xuedong
2009-08-01
Mps1 is one of the several essential kinases whose activation is required for robust mitotic spindle checkpoint signalling. The activity of Mps1 is tightly regulated and increases dramatically during mitosis or in response to spindle damage. To understand the molecular mechanism underlying Mps1 regulation, we determined the crystal structure of the kinase domain of Mps1. The 2.7-A-resolution crystal structure shows that the Mps1 kinase domain adopts a unique inactive conformation. Intramolecular interactions between the key Glu residue in the C helix of the N-terminal lobe and the backbone amides in the catalytic loop lock the kinase in the inactive conformation. Autophosphorylation appears to be a priming event for kinase activation. We identified Mps1 autophosphorylation sites in the activation and the P+1 loops. Whereas activation loop autophosphorylation enhances kinase activity, autophosphorylation at the P+1 loop (T686) is associated with the active kinase. Mutation of T686 autophosphorylation site impairs both autophosphorylation and transphosphorylation. Furthermore, we demonstrated that phosphorylation of T676 may be a priming event for phosphorylation at T686. Finally, we identified two critical lysine residues in the loop between helices EF and F that are essential for substrate recruitment and maintaining high levels of kinase activity. Our studies reveal critical biochemical mechanisms for Mps1 kinase regulation.
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Validation of a modified Medical Resource Model for mass gatherings.
Smith, Wayne P; Tuffin, Heather; Stratton, Samuel J; Wallis, Lee A
2013-02-01
A modified Medical Resource Model to predict the medical resources required at mass gatherings based on the risk profile of events has been developed. This study was undertaken to validate this tool using data from events held in both a developed and a developing country. A retrospective study was conducted utilizing prospectively gathered data from individual events at Old Trafford Stadium in Manchester, United Kingdom, and Ellis Park Stadium, Johannesburg, South Africa. Both stadia are similar in design and spectator capacity. Data for Professional Football as well as Rugby League and Rugby Union (respectively) matches were used for the study. The medical resources predicted for the events were determined by entering the risk profile of each of the events into the Medical Resource Model. A recently developed South African tool was used to predetermine medical staffing for mass gatherings. For the study, the medical resources actually required to deal with the patient load for events within the control sample from the two stadia were compared with the number of needed resources predicted by the Medical Resource Model when that tool was applied retrospectively to the study events. The comparison was used to determine if the newly developed tool was either over- or under-predicting the resource requirements. In the case of Ellis Park, the model under-predicted the basic life support (BLS) requirement for 1.5% of the events in the data set. Mean over-prediction was 209.1 minutes for BLS availability. Old Trafford displayed no events for which the Medical Resource Model would have under-predicted. The mean over-prediction of BLS availability for Old Trafford was 671.6 minutes. The intermediate life support (ILS) requirement for Ellis Park was under-predicted for seven of the total 66 events (10.6% of the events), all of which had one factor in common, that being relatively low spectator attendance numbers. Modelling for ILS at Old Trafford did not under-predict for any events. The ILS requirements showed a mean over-prediction of 161.4 minutes ILS availability for Ellis Park compared with 425.2 minutes for Old Trafford. Of the events held at Ellis Park, the Medical Resource Model under-predicted the ambulance requirement in 4.5% of the events. For Old Trafford events, the under-prediction was higher: 7.5% of cases. The medical resources that are deployed at a mass gathering should best match the requirement for patient care at a particular event. An important consideration for any model is that it does not continually under-predict the resources required in relation to the actual requirement. With the exception of a specific subset of events at Ellis Park, the rate of under-prediction for this model was acceptable.
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Thermally activated creep and fluidization in flowing disordered materials
NASA Astrophysics Data System (ADS)
Merabia, Samy; Detcheverry, François
2016-11-01
When submitted to a constant mechanical load, many materials display power law creep followed by fluidization. A fundamental understanding of these processes is still far from being achieved. Here, we characterize creep and fluidization on the basis of a mesoscopic viscoplastic model that includes thermally activated yielding events and a broad distribution of energy barriers, which may be lowered under the effect of a local deformation. We relate the creep exponent observed before fluidization to the width of barrier distribution and to the specific form of stress redistribution following yielding events. We show that Andrade creep is accompanied by local strain hardening driven by stress redistribution and find that the fluidization time depends exponentially on the applied stress. The simulation results are interpreted in the light of a mean-field analysis, and should help in rationalizing the creep phenomenology in disordered materials.
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Georga, Eleni I; Protopappas, Vasilios C; Ardigò, Diego; Polyzos, Demosthenes; Fotiadis, Dimitrios I
2013-08-01
The prevention of hypoglycemic events is of paramount importance in the daily management of insulin-treated diabetes. The use of short-term prediction algorithms of the subcutaneous (s.c.) glucose concentration may contribute significantly toward this direction. The literature suggests that, although the recent glucose profile is a prominent predictor of hypoglycemia, the overall patient's context greatly impacts its accurate estimation. The objective of this study is to evaluate the performance of a support vector for regression (SVR) s.c. glucose method on hypoglycemia prediction. We extend our SVR model to predict separately the nocturnal events during sleep and the non-nocturnal (i.e., diurnal) ones over 30-min and 60-min horizons using information on recent glucose profile, meals, insulin intake, and physical activities for a hypoglycemic threshold of 70 mg/dL. We also introduce herein additional variables accounting for recurrent nocturnal hypoglycemia due to antecedent hypoglycemia, exercise, and sleep. SVR predictions are compared with those from two other machine learning techniques. The method is assessed on a dataset of 15 patients with type 1 diabetes under free-living conditions. Nocturnal hypoglycemic events are predicted with 94% sensitivity for both horizons and with time lags of 5.43 min and 4.57 min, respectively. As concerns the diurnal events, when physical activities are not considered, the sensitivity is 92% and 96% for a 30-min and 60-min horizon, respectively, with both time lags being less than 5 min. However, when such information is introduced, the diurnal sensitivity decreases by 8% and 3%, respectively. Both nocturnal and diurnal predictions show a high (>90%) precision. Results suggest that hypoglycemia prediction using SVR can be accurate and performs better in most diurnal and nocturnal cases compared with other techniques. It is advised that the problem of hypoglycemia prediction should be handled differently for nocturnal and diurnal periods as regards input variables and interpretation of results.
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A Climatology of Nocturnal-Convection Initiation Over the Central Great Plains
NASA Astrophysics Data System (ADS)
Reif, D. W.; Bluestein, H. B.
2015-12-01
A nocturnal maximum in rainfall and thunderstorm activity over the central Great Plains is widely documented, but the mechanisms for understanding the development of thunderstorms over the region at night are still not well understood. Elevated convection, defined by Colman (1990) as storms formed through ascent above frontal surfaces, is one explanation, but our study shows that many thunderstorms can initiate at night without the presence of an elevated frontal inversion or nearby surface boundary. We address the following questions: Of all the events documented, what percentage fall under this definition of elevated convection, and what percentage fall outside of that definition? How do characteristics differ among the events that fall under that definition and the events that fall outside that definition? This study documents convection initiation (CI) events occurring at night over the central Great Plains from 1996 through 2014 during the months of April through July. Storm characteristics such as storm type (defined as linear, areal, or single cell), storm motion, initiation time and location, and others were documented. Once all of the cases were documented, surface data were examined to locate any nearby surface boundaries. The event's location relative to these boundaries (if they existed) was documented. Three main modes of CI were identified: formation on a surface boundary, formation on the cold side of a surface boundary, and formation without the presence of a surface boundary. A climatology of these events will be presented. There are many differences among the different modes of CI at night. One result is that there appears to be two main peaks of CI time at night: one early at night and one later at night. The later peak is likely due to the events that form in the absence of a nearby surface boundary.
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Seismic sample areas defined from incomplete catalogues: an application to the Italian territory
NASA Astrophysics Data System (ADS)
Mulargia, F.; Tinti, S.
1985-11-01
The comprehensive understanding of earthquake source-physics under real conditions requires the study not of single faults as separate entities but rather of a seismically active region as a whole, accounting for the interaction among different structures. We define "seismic sample area" the most convenient region to be used as a natural laboratory for the study of seismic source physics. This coincides with the region where the average large magnitude seismicity is the highest. To this end, time and space future distributions of large earthquakes are to be estimated. Using catalog seismicity as an input, the rate of occurrence is not constant but appears generally biased by incompleteness in some parts of the catalog and possible nonstationarities in seismic activity. We present a statistical procedure which is capable, under a few mild assumptions, of both detecting nonstationarities in seismicity and finding the incomplete parts of a seismic catalog. The procedure is based on Kolmogorov-Smirnov nonparametric statistics, and can be applied without a priori assuming the parent distribution of the events. The efficiency of this procedure allows the analysis of small data sets. An application to the Italian territory is presented, using the most recent version of the ENEL seismic catalog. Seismic activity takes place in six well defined areas but only five of them have a number of events sufficient for analysis. Barring a few exceptions, seismicity is found stationary throughout the whole catalog span 1000-1980. The eastern Alps region stands out as the best "sample area", with the highest average probability of event occurrence per time and area unit. Final objective of this characterization is to stimulate a program of intensified research.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Ozerov, Oleg V; Ozerov, Oleg V.
2014-01-16
We became interested in developing new methods for hydrodefluorination (HDF) and other types of C-F bond conversion in polyfluoroalkanes under mild conditions. We were attracted to an approach to C-F activation, where the key C-F cleavage proceeds by a Lewis acid abstraction of fluoride rather than a redox event. The efforts during the previous period were aimed at a) advancing the HDF reactivity with improvement in scope and catalyst longevity; b) extending C-F activation beyond HDF; c) generating insight about the elementary steps of the reaction and potential intermediates.
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The Resilience of Microbial Community under Drying and Rewetting Cycles of Three Forest Soils.
Zhou, Xue; Fornara, Dario; Ikenaga, Makoto; Akagi, Isao; Zhang, Ruifu; Jia, Zhongjun
2016-01-01
Forest soil ecosystems are associated with large pools and fluxes of carbon (C) and nitrogen (N), which could be strongly affected by variation in rainfall events under current climate change. Understanding how dry and wet cycle events might influence the metabolic state of indigenous soil microbes is crucial for predicting forest soil responses to environmental change. We used 454 pyrosequencing and quantitative PCR to address how present (DNA-based) and potentially active (RNA-based) soil bacterial communities might response to the changes in water availability across three different forest types located in two continents (Africa and Asia) under controlled drying and rewetting cycles. Sequencing of rRNA gene and transcript indicated that Proteobacteria, Actinobacteria, and Acidobacteria were the most responsive phyla to changes in water availability. We defined the ratio of rRNA transcript to rRNA gene abundance as a key indicator of potential microbial activity and we found that this ratio was increased following soil dry-down process whereas it decreased after soil rewetting. Following rewetting Crenarchaeota-like 16S rRNA gene transcript increased in some forest soils and this was linked to increases in soil nitrate levels suggesting greater nitrification rates under higher soil water availability. Changes in the relative abundance of (1) different microbial phyla and classes, and (2) 16S and amoA genes were found to be site- and taxa-specific and might have been driven by different life-strategies. Overall, we found that, after rewetting, the structure of the present and potentially active bacterial community structure as well as the abundance of bacterial (16S), archaeal (16S) and ammonia oxidizers (amoA), all returned to pre-dry-down levels. This suggests that microbial taxa have the ability to recover from desiccation, a critical response, which will contribute to maintaining microbial biodiversity in harsh ecosystems under environmental perturbations, such as significant changes in water availability.
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The Resilience of Microbial Community under Drying and Rewetting Cycles of Three Forest Soils
Zhou, Xue; Fornara, Dario; Ikenaga, Makoto; Akagi, Isao; Zhang, Ruifu; Jia, Zhongjun
2016-01-01
Forest soil ecosystems are associated with large pools and fluxes of carbon (C) and nitrogen (N), which could be strongly affected by variation in rainfall events under current climate change. Understanding how dry and wet cycle events might influence the metabolic state of indigenous soil microbes is crucial for predicting forest soil responses to environmental change. We used 454 pyrosequencing and quantitative PCR to address how present (DNA-based) and potentially active (RNA-based) soil bacterial communities might response to the changes in water availability across three different forest types located in two continents (Africa and Asia) under controlled drying and rewetting cycles. Sequencing of rRNA gene and transcript indicated that Proteobacteria, Actinobacteria, and Acidobacteria were the most responsive phyla to changes in water availability. We defined the ratio of rRNA transcript to rRNA gene abundance as a key indicator of potential microbial activity and we found that this ratio was increased following soil dry-down process whereas it decreased after soil rewetting. Following rewetting Crenarchaeota-like 16S rRNA gene transcript increased in some forest soils and this was linked to increases in soil nitrate levels suggesting greater nitrification rates under higher soil water availability. Changes in the relative abundance of (1) different microbial phyla and classes, and (2) 16S and amoA genes were found to be site- and taxa-specific and might have been driven by different life-strategies. Overall, we found that, after rewetting, the structure of the present and potentially active bacterial community structure as well as the abundance of bacterial (16S), archaeal (16S) and ammonia oxidizers (amoA), all returned to pre-dry-down levels. This suggests that microbial taxa have the ability to recover from desiccation, a critical response, which will contribute to maintaining microbial biodiversity in harsh ecosystems under environmental perturbations, such as significant changes in water availability. PMID:27486444
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Microfluidics and Coagulation Biology
Colace, Thomas V.; Tormoen, Garth W.
2014-01-01
The study of blood ex vivo can occur in closed or open systems, with or without flow. Microfluidic devices facilitate measurements of platelet function, coagulation biology, cellular biorheology, adhesion dynamics, pharmacology, and clinical diagnostics. An experimental session can accommodate 100s to 1000s of unique clotting events. Using microfluidics, thrombotic events can be studied on defined surfaces of biopolymers, matrix proteins, and tissue factor under constant flow rate or constant pressure drop conditions. Distinct shear rates can be created on a device with a single perfusion pump. Microfluidic devices facilitated the determination of intraluminal thrombus permeability and the discovery that platelet contractility can be activated by a sudden decrease in flow. Microfluidics are ideal for multicolor imaging of platelets, fibrin, and phosphatidylserine and provide a human blood analog to the mouse injury models. Overall, microfluidic advances offer many opportunities for research, drug testing under relevant hemodynamic conditions, and clinical diagnostics. PMID:23642241
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The neural correlates of trait resilience when anticipating and recovering from threat
Waugh, Christian E.; Wager, Tor D.; Fredrickson, Barbara L.; Noll, Doug C.; Taylor, Stephan F.
2008-01-01
A facet of emotional resilience critical for adapting to adversity is flexible use of emotional resources. We hypothesized that in threatening situations, this emotional flexibility enables resilient people to use emotional resources during appropriately emotional events, and conserve emotional resources during innocuous events. We tested this hypothesis using functional magnetic resonance imaging in a repeated recovery from threat task with low- and high-trait resilient individuals (LowR and HighR, respectively, as measured by ER89). In an event-related design, 13 HighR and 13 LowR participants viewed ‘threat’ cues, which signaled either an aversive or neutral picture with equal probabilities, or ‘nonthreat’ cues, which signaled a neutral picture. Results show that when under threat, LowR individuals exhibited prolonged activation in the anterior insula to both the aversive and neutral pictures, whereas HighR individuals exhibited insula activation only to the aversive pictures. These data provide neural evidence that in threatening situations, resilient people flexibly and appropriately adjust the level of emotional resources needed to meet the demands of the situation. PMID:19015078
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Aad, G.; Abajyan, T.; Abbott, B.; ...
2014-08-12
Distributions sensitive to the underlying event in QCD jet events have been measured with the ATLAS detector at the LHC, based on 37 pb -1 of proton–proton collision data collected at a centre-of-mass energy of 7 TeV. Charged-particle mean p T and densities of all-particle E T and charged-particle multiplicity and p T have been measured in regions azimuthally transverse to the hardest jet in each event. These are presented both as one-dimensional distributions and with their mean values as functions of the leading-jet transverse momentum from 20 to 800 GeV. The correlation of charged-particle mean p T with charged-particlemore » multiplicity is also studied, and the E T densities include the forward rapidity region; these features provide extra data constraints for Monte Carlo modelling of colour reconnection and beam-remnant effects respectively. For the first time, underlying event observables have been computed separately for inclusive jet and exclusive dijet event selections, allowing more detailed study of the interplay of multiple partonic scattering and QCD radiation contributions to the underlying event. Comparisons to the predictions of different Monte Carlo models show a need for further model tuning, but the standard approach is found to generally reproduce the features of the underlying event in both types of event selection.« less
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Mason, Clifford W; Swaan, Peter W; Weiner, Carl P
2006-06-01
The transition from myometrial quiescence to activation is poorly understood, and the analysis of array data is limited by the available data mining tools. We applied functional analysis and logical operations along regulatory gene networks to identify molecular processes and pathways underlying quiescence and activation. We analyzed some 18,400 transcripts and variants in guinea pig myometrium at stages corresponding to quiescence and activation, and compared them to the nonpregnant (control) counterpart using a functional mapping tool, MetaCore (GeneGo, St Joseph, MI) to identify novel gene networks composed of biological pathways during mid (MP) and late (LP) pregnancy. Genes altered during quiescence and or activation were identified following gene specific comparisons with myometrium from nonpregnant animals, and then linked to curated pathways and formulated networks. The MP and LP networks were subtracted from each other to identify unique genomic events during those periods. For example, changes 2-fold or greater in genes mediating protein biosynthesis, programmed cell death, microtubule polymerization, and microtubule based movement were noted during the transition to LP. We describe a novel approach combining microarrays and genetic data to identify networks associated with normal myometrial events. The resulting insights help identify potential biomarkers and permit future targeted investigations of these pathways or networks to confirm or refute their importance.
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Blessing, William; Ootsuka, Youichirou
2016-01-01
Charles Darwin noted that natural selection applies even to the hourly organization of daily life. Indeed, in many species, the day is segmented into active periods when the animal searches for food, and inactive periods when the animal digests and rests. This episodic temporal patterning is conventionally referred to as ultradian (<24 hours) rhythmicity. The average time between ultradian events is approximately 1-2 hours, but the interval is highly variable. The ultradian pattern is stochastic, jaggy rather than smooth, so that although the next event is likely to occur within 1-2 hours, it is not possible to predict the precise timing. When models of circadian timing are applied to the ultradian temporal pattern, the underlying assumption of true periodicity (stationarity) has distorted the analyses, so that the ultradian pattern is frequently averaged away and ignored. Each active ultradian episode commences with an increase in hippocampal theta rhythm, indicating the switch of attention to the external environment. During each active episode, behavioral and physiological processes, including changes in body and brain temperature, occur in an integrated temporal order, confirming organization by programs endogenous to the central nervous system. We describe methods for analyzing episodic ultradian events, including the use of wavelet mathematics to determine their timing and amplitude, and the use of fractal-based procedures to determine their complexity.
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Blessing, William; Ootsuka, Youichirou
2016-01-01
ABSTRACT Charles Darwin noted that natural selection applies even to the hourly organization of daily life. Indeed, in many species, the day is segmented into active periods when the animal searches for food, and inactive periods when the animal digests and rests. This episodic temporal patterning is conventionally referred to as ultradian (<24 hours) rhythmicity. The average time between ultradian events is approximately 1–2 hours, but the interval is highly variable. The ultradian pattern is stochastic, jaggy rather than smooth, so that although the next event is likely to occur within 1–2 hours, it is not possible to predict the precise timing. When models of circadian timing are applied to the ultradian temporal pattern, the underlying assumption of true periodicity (stationarity) has distorted the analyses, so that the ultradian pattern is frequently averaged away and ignored. Each active ultradian episode commences with an increase in hippocampal theta rhythm, indicating the switch of attention to the external environment. During each active episode, behavioral and physiological processes, including changes in body and brain temperature, occur in an integrated temporal order, confirming organization by programs endogenous to the central nervous system. We describe methods for analyzing episodic ultradian events, including the use of wavelet mathematics to determine their timing and amplitude, and the use of fractal-based procedures to determine their complexity. PMID:28349079
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Gabdoulline, Razif R; Wade, Rebecca C
2009-07-08
The factors that determine the extent to which diffusion and thermal activation processes govern electron transfer (ET) between proteins are debated. The process of ET between plastocyanin (PC) and cytochrome f (CytF) from the cyanobacterium Phormidium laminosum was initially thought to be diffusion-controlled but later was found to be under activation control (Schlarb-Ridley, B. G.; et al. Biochemistry 2005, 44, 6232). Here we describe Brownian dynamics simulations of the diffusional association of PC and CytF, from which ET rates were computed using a detailed model of ET events that was applied to all of the generated protein configurations. The proteins were modeled as rigid bodies represented in atomic detail. In addition to electrostatic forces, which were modeled as in our previous simulations of protein-protein association, the proteins interacted by a nonpolar desolvation (hydrophobic) force whose derivation is described here. The simulations yielded close to realistic residence times of transient protein-protein encounter complexes of up to tens of microseconds. The activation barrier for individual ET events derived from the simulations was positive. Whereas the electrostatic interactions between P. laminosum PC and CytF are weak, simulations for a second cyanobacterial PC-CytF pair, that from Nostoc sp. PCC 7119, revealed ET rates influenced by stronger electrostatic interactions. In both cases, the simulations imply significant contributions to ET from both diffusion and thermal activation processes.
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Anti-lock brake system: an assessment of training on driver effectiveness.
Mollenhauer, M A; Dingus, T A; Carney, C; Hankey, J M; Jahns, S
1997-01-01
When activated correctly, Anti-Lock Brake Systems (ABS) can provide drivers with the ability to stop a vehicle in shorter distances and allow for more vehicle control under heavy braking than conventional brake systems. This is especially true under wet or icy road conditions. However, it is believed that many drivers are either unaware of the correct method of activation or they revert back to the old method of pumping the brakes when they are faced with a hard braking situation. This paper examines the effectiveness of implementing low-cost training methods for alerting drivers to the correct brake activation technique. A 4-page, color training pamphlet was developed and subjects were given a short period of time to read it over before being asked to drive on an icy test track. Results indicated that those subjects who received the training were able to stop in shorter distances in a straight line braking event and more often used the correct brake activation technique than those subjects who did not receive the training. However, the stopping distance benefits were not realized in the curved and surprise braking events. These results suggest that the transfer of verbal knowledge may have value as a means for solving the apparent problem of improper ABS usage. However, some additional research should be done to validate these results. Since this experiment was conducted directly after the material was read, the possibility exists that without reinforcement, the trained braking techniques might become extinct in a short period of time.
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Virtual Seismometers for Induced Seismicity Monitoring and Full Moment Tensor Inversion
NASA Astrophysics Data System (ADS)
Morency, C.; Matzel, E.
2016-12-01
Induced seismicity is associated with subsurface fluid injection, and puts at risk efforts to develop geologic carbon sequestration and enhanced geothermal systems. We are developing methods to monitor the microseismically active zone so that we can ultimately identify faults at risk of slipping. The virtual seismometer method (VSM) is an interferometric technique that is very sensitive to the source parameters (location, mechanism and magnitude) and to the Earth structure in the source region. VSM works by virtually placing seismometers inside a micro events cloud, where we can focus on properties directly between induced micro events, and effectively replacing each earthquake with a virtual seismometer recording all the others. Here, we show that the cross-correlated signals from seismic wavefields triggered by two events and recorded at the surface are a combination of the strain field between these two sources times a moment tensor. Based on this relationship, we demonstrate how we can use these measured cross-correlated signals to invert for full moment tensor. The advantage of VSM is to allow to considerably reduce the modeled numerical domain to the region directly around the micro events cloud, which lowers computational cost, permits to reach higher frequency resolution, and suppresses the impact of the Earth structural model uncertainties outside the micro events cloud. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.
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Thermal remote sensing of active vegetation fires and biomass burning events [Chapter 18
Martin J. Wooster; Gareth Roberts; Alistair M.S. Smith; Joshua Johnston; Patrick Freeborn; Stefania Amici; Andrew T. Hudak
2013-01-01
Thermal remote sensing is widely used in the detection, study, and management of biomass burning occurring in open vegetation fires. Such fires may be planned for land management purposes, may occur as a result of a malicious or accidental ignition by humans, or may result from lightning or other natural phenomena. Under suitable conditions, fires may spread rapidly...
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ERIC Educational Resources Information Center
Watanabe, Hama; Homae, Fumitaka; Taga, Gentaro
2011-01-01
In young infants, activation or inhibition of body movements on perception of environmental events is important to enable them to act on the world or understand the world. To reveal the development of this ability, we observed movement patterns in all four limbs under the two experimental conditions. Infants assigned to the interaction condition…
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Cognitive caching promotes flexibility in task switching: evidence from event-related potentials.
Lange, Florian; Seer, Caroline; Müller, Dorothea; Kopp, Bruno
2015-12-08
Time-consuming processes of task-set reconfiguration have been shown to contribute to the costs of switching between cognitive tasks. We describe and probe a novel mechanism serving to reduce the costs of task-set reconfiguration. We propose that when individuals are uncertain about the currently valid task, one task set is activated for execution while other task sets are maintained at a pre-active state in cognitive cache. We tested this idea by assessing an event-related potential (ERP) index of task-set reconfiguration in a three-rule task-switching paradigm involving varying degrees of task uncertainty. In high-uncertainty conditions, two viable tasks were equally likely to be correct whereas in low-uncertainty conditions, one task was more likely than the other. ERP and performance measures indicated substantial costs of task-set reconfiguration when participants were required to switch away from a task that had been likely to be correct. In contrast, task-set-reconfiguration costs were markedly reduced when the previous task set was chosen under high task uncertainty. These results suggest that cognitive caching of alternative task sets adds to human cognitive flexibility under high task uncertainty.
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Cognitive caching promotes flexibility in task switching: evidence from event-related potentials
Lange, Florian; Seer, Caroline; Müller, Dorothea; Kopp, Bruno
2015-01-01
Time-consuming processes of task-set reconfiguration have been shown to contribute to the costs of switching between cognitive tasks. We describe and probe a novel mechanism serving to reduce the costs of task-set reconfiguration. We propose that when individuals are uncertain about the currently valid task, one task set is activated for execution while other task sets are maintained at a pre-active state in cognitive cache. We tested this idea by assessing an event-related potential (ERP) index of task-set reconfiguration in a three-rule task-switching paradigm involving varying degrees of task uncertainty. In high-uncertainty conditions, two viable tasks were equally likely to be correct whereas in low-uncertainty conditions, one task was more likely than the other. ERP and performance measures indicated substantial costs of task-set reconfiguration when participants were required to switch away from a task that had been likely to be correct. In contrast, task-set-reconfiguration costs were markedly reduced when the previous task set was chosen under high task uncertainty. These results suggest that cognitive caching of alternative task sets adds to human cognitive flexibility under high task uncertainty. PMID:26643146
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How can mass participation physical activity events engage low-active people? A qualitative study.
Early, Frances; Corcoran, Paula
2013-08-01
Regular, moderate physical activity reduces the risk of mortality and morbidity; however increasing the physical activity levels of less active people is a public health challenge. This study explores the potential of mass participation physical activity events to engage less active people, through analyzing the accounts of participants in 2 events who identified themselves as low-active before entering. Seven participants in a sponsored run and 7 in a sponsored walk were interviewed and transcripts were analyzed using grounded theory techniques. Participants had positive experiences encapsulated in 3 categories: Performing (physical completion of the event culminating in a sense of achievement); Relating (enjoying relationships); Soaking up the Atmosphere (enjoying the event ambience). The way in which these categories were manifested was affected by the event context. Mass participation events have potential to engage low-active people. The impact of participation resonated with factors that are positively associated with physical activity in other settings, and event characteristics matched key criteria for attracting low-active groups identified through social marketing research. Suggestions are given for how to capitalize on the findings for health promotion.
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A regressive storm model for extreme space weather
NASA Astrophysics Data System (ADS)
Terkildsen, Michael; Steward, Graham; Neudegg, Dave; Marshall, Richard
2012-07-01
Extreme space weather events, while rare, pose significant risk to society in the form of impacts on critical infrastructure such as power grids, and the disruption of high end technological systems such as satellites and precision navigation and timing systems. There has been an increased focus on modelling the effects of extreme space weather, as well as improving the ability of space weather forecast centres to identify, with sufficient lead time, solar activity with the potential to produce extreme events. This paper describes the development of a data-based model for predicting the occurrence of extreme space weather events from solar observation. The motivation for this work was to develop a tool to assist space weather forecasters in early identification of solar activity conditions with the potential to produce extreme space weather, and with sufficient lead time to notify relevant customer groups. Data-based modelling techniques were used to construct the model, and an extensive archive of solar observation data used to train, optimise and test the model. The optimisation of the base model aimed to eliminate false negatives (missed events) at the expense of a tolerable increase in false positives, under the assumption of an iterative improvement in forecast accuracy during progression of the solar disturbance, as subsequent data becomes available.
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NASA Astrophysics Data System (ADS)
Marchamalo, Miguel; Hooke, Janet; Gonzalez-Rodrigo, Beatriz; Sandercock, Peter
2017-04-01
Soil erosion and land degradation are severe problems in headwaters of ephemeral streams in semiarid Mediterranean regions, particularly in marginal upland areas over erodible parent material. Field-based information is required about the main pathways of sediment movement, the identification of sources and sinks and the influence of relevant factors. The EU-funded project RECONDES approached this reality by monitoring connectivity pathways of water and sediment movement in the landscape with the aim of identifying hotspots that could then be strategically targeted to reduce soil erosion and off-site effects. A protocol including field work and GIS analysis was developed and applied to a set of microcatchments in Carcavo Basin (Spain). The philosophy of the protocol was based on the repeated mapping after rainfall events so that frequency of activity of pathways could be evaluated. Connectivity was evaluated for each site and event using specific metrics: maximum mapped connectivity (corresponding to the largest recorded event), density of connected pathway links (m/ha) and frequency of activity (times active/total). Repeated connectivity mapping allowed identifying hotspots of erosion. The effect of structural and functional factors on connectivity was investigated. Field data is also valuable for validating future connectivity models in semiarid landscapes under highly variable and unpredictable conditions.
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Daily life stress reactivity in remitted versus non-remitted depressed individuals.
van Winkel, M; Nicolson, N A; Wichers, M; Viechtbauer, W; Myin-Germeys, I; Peeters, F
2015-06-01
Little is known about how daily life mood reactivity to minor stressors (stress reactivity) might change following major depressive disorder (MDD) treatment. We investigate whether (i) mood states and appraisals of daily stressors change after treatment; (ii) stress reactivity to event, activity, or social stress differs; (iii) stress reactivity depends on severity of residual depressive symptoms; and (iv) stress reactivity in individuals with remitted or non-remitted depression differ from that of never-depressed individuals. Thirty depressed individuals participated in an experience sampling study before and after a treatment period of 18 months; 39 healthy individuals formed a comparison group. Reactivity of positive affect (PA) and negative affect (NA) to daily stressors were measured. More residual symptoms were associated with larger NA responses to stress. Compared to healthy controls, participants with non-remitted MDD showed higher NA-reactivity to all stressors. In contrast, stress reactivity to event and activity stressors was normalized in remitted patients. However, they still showed heightened NA-reactivity to social stress. Greater stress reactivity to event and activity stress appears to be state-dependent. The heightened social stress reactivity in remitted patients suggests that sensitivity to social stress may reflect an underlying vulnerability in MDD. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
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Barnhart, William D.; Benz, Harley M.; Hayes, Gavin P.; Rubinstein, Justin L.; Bergman, E.
2014-01-01
The Raton Basin of southern Colorado and northern New Mexico is an actively produced hydrocarbon basin that has experienced increased seismicity since 2001, including the August 2011 Mw5.3 Trinidad normal faulting event. Following the 2011 earthquake, regional seismic observations were used to relocate 21 events, including the 2011 main shock, two foreshocks, and 13 aftershocks. Additionally, interferometric synthetic aperture radar (InSAR) observations of both the 2011 event and preevent basin deformation place constraint on the spatial kinematics of the 2011 event and localized basin subsidence due to ground water or gas withdrawal. We find that the 2011 earthquake ruptured an 8–10 km long segment of a normal fault at depths of 1.5–6.0 km within the crystalline Precambrian basement underlying the Raton Basin sedimentary rocks. The earthquake also nucleated within the crystalline basement in the vicinity of an active wastewater disposal site. The ensuing aftershock sequence demonstrated statistical properties expected for intraplate earthquakes, though the length of the 2011 earthquake is unexpectedly long for an Mw5.3 event, suggesting that wastewater disposal may have triggered a low stress drop, otherwise natural earthquake. Additionally, preevent and postevent seismicity in the Raton Basin spatially correlates to regions of subsidence observed in InSAR time series analysis. While these observations cannot discern a causal link between hydrocarbon production and seismicity, they constrain spatial relationships between active basin deformation and geological and anthropogenic features. Furthermore, the InSAR observations highlight the utility of space-based geodetic observations for monitoring and assessing anthropogenically induced and triggered deformation.
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NASA Astrophysics Data System (ADS)
Minadakis, George; Ventouras, Errikos; Gatzonis, Stylianos D.; Siatouni, Anna; Tsekou, Hara; Kalatzis, Ioannis; Sakas, Damianos E.; Stonham, John
2014-04-01
Objective. Recent cross-disciplinary literature suggests a dynamical analogy between earthquakes and epileptic seizures. This study extends the focus of inquiry for the applicability of models for earthquake dynamics to examine both scalp-recorded and intracranial electroencephalogram recordings related to epileptic seizures. Approach. First, we provide an updated definition of the electric event in terms of magnitude and we focus on the applicability of (i) a model for earthquake dynamics, rooted in a nonextensive Tsallis framework, (ii) the traditional Gutenberg and Richter law and (iii) an alternative method for the magnitude-frequency relation for earthquakes. Second, we apply spatiotemporal analysis in terms of nonextensive statistical physics and we further examine the behavior of the parameters included in the nonextensive formula for both types of electroencephalogram recordings under study. Main results. We confirm the previously observed power-law distribution, showing that the nonextensive formula can adequately describe the sequences of electric events included in both types of electroencephalogram recordings. We also show the intermittent behavior of the epileptic seizure cycle which is analogous to the earthquake cycles and we provide evidence of self-affinity of the regional electroencephalogram epileptic seizure activity. Significance. This study may provide a framework for the analysis and interpretation of epileptic brain activity and other biological phenomena with similar underlying dynamical mechanisms.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Bain, H. M.; Luhmann, J. G.; Li, Y.
During periods of increased solar activity, coronal mass ejections (CMEs) can occur in close succession and proximity to one another. This can lead to the interaction and merger of CME ejecta as they propagate in the heliosphere. The particles accelerated in these shocks can result in complex solar energetic particle (SEP) events, as observing spacecraft form both remote and local shock connections. It can be challenging to understand these complex SEP events from in situ profiles alone. Multipoint observations of CMEs in the near-Sun environment, from the Solar Terrestrial Relations Observatory –Sun Earth Connection Coronal and Heliospheric Investigation and themore » Solar and Heliospheric Observatory Large Angle and Spectrometric Coronagraph, greatly improve our chances of identifying the origin of these accelerated particles. However, contextual information on conditions in the heliosphere, including the background solar wind conditions and shock structures, is essential for understanding SEP properties well enough to forecast their characteristics. Wang–Sheeley–Arge WSA-ENLIL + Cone modeling provides a tool to interpret major SEP event periods in the context of a realistic heliospheric model and to determine how much of what is observed in large SEP events depends on nonlocal magnetic connections to shock sources. We discuss observations of the SEP-rich periods of 2010 August and 2012 July in conjunction with ENLIL modeling. We find that much SEP activity can only be understood in the light of such models, and in particular from knowing about both remote and local shock source connections. These results must be folded into the investigations of the physics underlying the longitudinal extent of SEP events, and the source connection versus diffusion pictures of interpretations of SEP events.« less
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NASA Astrophysics Data System (ADS)
Srivastava, Pradeep; Singh, Vimal
2017-05-01
Tectonically active Himalayan mountains evolves via feedbacks from deep earth and surface processes; the complex interaction of various processes results into the landscape which is dynamic both at longer and shorter time scales. The extreme hydrological events that possibly ride over a long term climate cycle bring the changes in the landscape that impact human societies more closely. These events in the Himalaya frequently cause huge damage to economy and human lives. The geologist community under the umbrella of Himalaya-Karakorum-Tibet (HKT) workshop in its 30th edition convened a special session and deliberated on the subject. This special issue "Quaternary of Himalaya" is an outcome of papers presented and discussion held during this session; it consists of 18 papers in three sub-themes (i) Extreme Events in Himalaya (ii) Paleoglaciation in Himalaya and (iii) Expressions of climate and neotectonics in Himalaya.
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Collapse of Experimental Colloidal Aging using Record Dynamics
NASA Astrophysics Data System (ADS)
Robe, Dominic; Boettcher, Stefan; Sibani, Paolo; Yunker, Peter
The theoretical framework of record dynamics (RD) posits that aging behavior in jammed systems is controlled by short, rare events involving activation of only a few degrees of freedom. RD predicts dynamics in an aging system to progress with the logarithm of t /tw . This prediction has been verified through new analysis of experimental data on an aging 2D colloidal system. MSD and persistence curves spanning three orders of magnitude in waiting time are collapsed. These predictions have also been found consistent with a number of experiments and simulations, but verification of the specific assumptions that RD makes about the underlying statistics of these rare events has been elusive. Here the observation of individual particles allows for the first time the direct verification of the assumptions about event rates and sizes. This work is suppoted by NSF Grant DMR-1207431.
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Molecular brake pad hypothesis: pulling off the brakes for emotional memory
Vogel-Ciernia, Annie
2015-01-01
Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. PMID:23096102
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Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity▿
Funakoshi-Tago, Megumi; Pelletier, Stéphane; Moritake, Hiroshi; Parganas, Evan; Ihle, James N.
2008-01-01
Janus kinases are essential for signal transduction by a variety of cytokine receptors and when inappropriately activated can cause hematopoietic disorders and oncogenesis. Consequently, it can be predicted that the interaction of the kinases with receptors and the events required for activation are highly controlled. In a screen to identify phosphorylation events regulating Jak2 activity in EpoR signaling, we identified a mutant (Jak2-Y613E) which has the property of being constitutively activated, as well as an inactivating mutation (Y766E). Although no evidence was obtained to indicate that either site is phosphorylated in signaling, the consequences of the Y613E mutation are similar to those observed with recently described activating mutations in Jak2 (Jak2-V617F and Jak2-L611S). However, unlike the V617F or L611S mutant, the Y613E mutant requires the presence of the receptor but not Epo stimulation for activation and downstream signaling. The properties of the Jak2-Y613E mutant suggest that under normal conditions, Jak2 that is not associated with a receptor is locked into an inactive state and receptor binding through the FERM domain relieves steric constraints, allowing the potential to be activated with receptor engagement. PMID:18160720
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A Strategic Framework for Responding to Coral Bleaching Events in a Changing Climate
NASA Astrophysics Data System (ADS)
Maynard, J. A.; Johnson, J. E.; Marshall, P. A.; Eakin, C. M.; Goby, G.; Schuttenberg, H.; Spillman, C. M.
2009-07-01
The frequency and severity of mass coral bleaching events are predicted to increase as sea temperatures continue to warm under a global regime of rising ocean temperatures. Bleaching events can be disastrous for coral reef ecosystems and, given the number of other stressors to reefs that result from human activities, there is widespread concern about their future. This article provides a strategic framework from the Great Barrier Reef to prepare for and respond to mass bleaching events. The framework presented has two main inter-related components: an early warning system and assessment and monitoring. Both include the need to proactively and consistently communicate information on environmental conditions and the level of bleaching severity to senior decision-makers, stakeholders, and the public. Managers, being the most timely and credible source of information on bleaching events, can facilitate the implementation of strategies that can give reefs the best chance to recover from bleaching and to withstand future disturbances. The proposed framework is readily transferable to other coral reef regions, and can easily be adapted by managers to local financial, technical, and human resources.
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The effects of curiosity-evoking events on activity enjoyment.
Isikman, Elif; MacInnis, Deborah J; Ülkümen, Gülden; Cavanaugh, Lisa A
2016-09-01
Whereas prior literature has studied the positive effects of curiosity-evoking events that are integral to focal activities, we explore whether and how a curiosity-evoking event that is incidental to a focal activity induces negative outcomes for enjoyment. Four experiments and 1 field study demonstrate that curiosity about an event that is incidental to an activity in which individuals are engaged, significantly affects enjoyment of a concurrent activity. The reason why is that curiosity diverts attention away from the concurrent activity and focuses attention on the curiosity-evoking event. Thus, curiosity regarding an incidental event decreases enjoyment of a positive focal activity but increases enjoyment of a negative focal activity. PsycINFO Database Record (c) 2016 APA, all rights reserved
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Borjesson, Mats; Urhausen, Alex; Kouidi, Evangelia; Dugmore, Dorian; Sharma, Sanjay; Halle, Martin; Heidbüchel, Hein; Björnstad, Hans Halvor; Gielen, Stephan; Mezzani, Alessandro; Corrado, Domenico; Pelliccia, Antonio; Vanhees, Luc
2011-06-01
Regular aerobic exercise at moderate intensities and an increased physical fitness are associated with a reduced risk of fatal and nonfatal coronary events in middle-aged individuals. In contrast, moderate and vigorous physical exertion is associated with an increased risk for cardiac events, including sudden cardiac death in individuals harbouring cardiovascular disease. The risk-benefit ratio may differ in relation to the individual’s age, fitness level, and presence of cardiovascular disease; sedentary individuals with underlying coronary artery disease are at greatest risk. The intention of the present position stand of the European Association of Cardiovascular Prevention and Rehabilitation is to encourage individuals to participate in regular physical activity and derive the benefits of physical exercise while minimizing the risk of cardiovascular adverse events. Therefore, the aim is to establish the most practical method of cardiovascular evaluation in middle-age/senior individuals, who are contemplating exercise or who are already engaged in nonprofessional competitive or recreational leisure sporting activity. These recommendations rely on existing scientific evidence, and in the absence of such, on expert consensus. The methodology of how middle-aged and older individuals should be evaluated appropriately before engaging in regular physical activity is both complex and controversial. On practical grounds the consensus panel recommend that such evaluation should vary according to the individual’s cardiac risk profile and the intended level of physical activity. Self assessment of the habitual physical activity level and of the risk factors, are recommended for screening of large populations. Individuals deemed to be at risk require further evaluation by a qualified physician. In senior/adult individuals with an increased risk for coronary events, maximal exercise testing (and possibly further evaluations) is advocated. Hopefully, the recommendations in this paper provide a practical solution for facilitating safe exercise prescription in senior/adults.
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Imaging a seizure model in zebrafish with structured illumination light sheet microscopy
NASA Astrophysics Data System (ADS)
Liu, Yang; Dale, Savannah; Ball, Rebecca; VanLeuven, Ariel J.; Baraban, Scott; Sornborger, Andrew; Lauderdale, James D.; Kner, Peter
2018-02-01
Zebrafish are a promising vertebrate model for elucidating how neural circuits generate behavior under normal and pathological conditions. The Baraban group first demonstrated that zebrafish larvae are valuable for investigating seizure events and can be used as a model for epilepsy in humans. Because of their small size and transparency, zebrafish embryos are ideal for imaging seizure activity using calcium indicators. Light-sheet microscopy is well suited to capturing neural activity in zebrafish because it is capable of optical sectioning, high frame rates, and low excitation intensities. We describe work in our lab to use light-sheet microscopy for high-speed long-time imaging of neural activity in wildtype and mutant zebrafish to better understand the connectivity and activity of inhibitory neural networks when GABAergic signaling is altered in vivo. We show that, with light-sheet microscopy, neural activity can be recorded at 23 frames per second in twocolors for over 10 minutes allowing us to capture rare seizure events in mutants. We have further implemented structured illumination to increase resolution and contrast in the vertical and axial directions during high-speed imaging at an effective frame rate of over 7 frames per second.
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Shi, Longqing; Vasseur, Liette; Huang, Huoshui; Zeng, Zhaohua; Hu, Guiping; Liu, Xin; You, Minsheng
2017-01-01
Insect behaviors are often influenced by light conditions including photoperiod, light intensity, and wavelength. Understanding pest insect responses to changing light conditions may help with developing alternative strategies for pest control. Little is known about the behavioral responses of leafhoppers (Hemiptera: Cicadellidae) to light conditions. The behavior of the tea green leafhopper, Empoasca onukii Matsuda, was examined when exposed to different light photoperiods or wavelengths. Observations included the frequency of locomotion and cleaning activities, and the duration of time spent searching. The results suggested that under normal photoperiod both female and male adults were generally more active in darkness (i.e., at night) than in light. In continuous darkness (DD), the locomotion and cleaning events in Period 1 (7:00–19:00) were significantly increased, when compared to the leafhoppers under normal photoperiod (LD). Leafhoppers, especially females, changed their behavioral patterns to a two day cycle under DD. Under continuous illumination (continuous quartz lamp light, yellow light at night, and green light at night), the activities of locomotion, cleaning, and searching were significantly suppressed during the night (19:00–7:00) and locomotion activities of both females and males were significantly increased during the day (7:00–19:00), suggesting a shift in circadian rhythm. Our work suggests that changes in light conditions, including photoperiod and wavelength, can influence behavioral activities of leafhoppers, potentially affecting other life history traits such as reproduction and development, and may serve as a method for leafhopper behavioral control. PMID:28103237
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Shi, Longqing; Vasseur, Liette; Huang, Huoshui; Zeng, Zhaohua; Hu, Guiping; Liu, Xin; You, Minsheng
2017-01-01
Insect behaviors are often influenced by light conditions including photoperiod, light intensity, and wavelength. Understanding pest insect responses to changing light conditions may help with developing alternative strategies for pest control. Little is known about the behavioral responses of leafhoppers (Hemiptera: Cicadellidae) to light conditions. The behavior of the tea green leafhopper, Empoasca onukii Matsuda, was examined when exposed to different light photoperiods or wavelengths. Observations included the frequency of locomotion and cleaning activities, and the duration of time spent searching. The results suggested that under normal photoperiod both female and male adults were generally more active in darkness (i.e., at night) than in light. In continuous darkness (DD), the locomotion and cleaning events in Period 1 (7:00-19:00) were significantly increased, when compared to the leafhoppers under normal photoperiod (LD). Leafhoppers, especially females, changed their behavioral patterns to a two day cycle under DD. Under continuous illumination (continuous quartz lamp light, yellow light at night, and green light at night), the activities of locomotion, cleaning, and searching were significantly suppressed during the night (19:00-7:00) and locomotion activities of both females and males were significantly increased during the day (7:00-19:00), suggesting a shift in circadian rhythm. Our work suggests that changes in light conditions, including photoperiod and wavelength, can influence behavioral activities of leafhoppers, potentially affecting other life history traits such as reproduction and development, and may serve as a method for leafhopper behavioral control.
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Saud, Shah; Yajun, Chen; Fahad, Shah; Hussain, Saddam; Na, Li; Xin, Li; Alhussien, Safa Abd Alaleem Fadal Elseed
2016-09-01
Drought stress is the most pervasive threat to plant growth, which disrupts the photosynthesis and its associated metabolic activities, while silicate (Si) application may have the potential to alleviate the damaging effects of drought on plant growth. In present study, the role of Si in regulating the photosynthesis and its associated metabolic events in Kentucky bluegrass (cv. Arcadia) were investigated under drought stress. Drought stress and four levels (0, 200, 400, 800 mg L(-1)) of Si (Na2SiO3.9H2O) were imposed on 1-year-old plants removed from field and cultured under glasshouse conditions. After 20 days of drought stress, the plants were re-watered to reach soil field capacity for the examination of recovery on the second and the seventh day. The experiment was arranged in completely randomized design replicated four times. Drought stress severely decreased the photosynthesis, water use efficiency, stomatal conductance, cholorophyll contents, Rubisco activity, and Rubisco activation state in Kentucky bluegrass. Nevertheless, application of Si had a positive influence on all these attributes, particularly under stress conditions. As compared to control, Si application at 400 mg L(-1) recorded 78, 64, and 48 % increase in photosynthesis, Rubisco initial activity, and Rubisco total activity, respectively, at 20 days of drought. Higher photosynthesis and higher Rubisco activity in Si-applied treatments suggest that Si may have possible (direct or indirect) role in maintenance of more active Rubisco enzyme and Rubisco activase and more stable proteins for carbon assimilation under stress conditions, which needs to be elucidated in further studies.
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Exploring Your Universe at UCLA: Steps to Developing and Sustaining a Large STEM Event
NASA Astrophysics Data System (ADS)
Curren, I. S.; Vican, L.; Sitarski, B.; Jewitt, D. C.
2015-12-01
Public STEM events are an excellent method to implement informal education and for scientists and educators to interact with their community. The benefits of such events are twofold. First and foremost, science enthusiasts and students both young and old, in particular, are exposed to STEM in a way that is accessible, fun, and not as stringent as may be presented in classrooms where testing is an underlying goal. Second, scientists and educators are given the opportunity to engage with the public and share their science to an audience who may not have a scientific background, thereby encouraging scientists to develop good communication practices and skills. In 2009 graduate student members of Astronomy Live!, an outreach organization in the UCLA Department of Physics and Astronomy, started a free and public event on the campus that featured a dozen hands-on outreach activities. The event, though small at the time, was a success and it was decided to make it an annual occurrence. Thus, Exploring Your Universe (EYU) was born. Primarily through word of mouth, the event has grown every year, both in number of attendees and number of volunteers. In 2009, approximately 1000 people attended and 20 students volunteered over the course of an eight-hour day. In 2014, participation was at an all-time high with close to 6000 attendees and over 400 volunteers from all departments in the Division of Physical Sciences (plus many non-divisional departments and institutes, as well as non-UCLA organizations). The event, which is the largest STEM event at UCLA and one of the largest in Los Angeles, now features near 100 hands-on activities that span many STEM fields. EYU has been featured by the UCLA news outlets, Daily Bruin and UCLA Today, and is often lauded as their favorite event of the year by attendees and volunteers alike. The event is entirely student-run, though volunteers include faculty, staff, researchers and students alike. As the event has grown, new systems for managing its many aspects have been adopted. Here, we will present the details of how the event was created and has remained successful, and sustainable.
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Sensory Transduction and Electrical Signaling in Guard Cells
Serrano, Elba E.; Zeiger, Eduardo
1989-01-01
Guard cells are a valuable model system for the study of photoreception, ion transport, and osmoregulation in plant cells. Changes in stomatal apertures occur when sensing mechanisms within the guard cells transduce environmental stimull into the ion fluxes and biosynthesis of organic solutes that regulate turgor. The electrical events mediating sensory transduction in guard cells can be characterized with a variety of electrophysiological recording techniques. Recent experiments applying the patch clamp method to guard cell protoplasts have demonstrated activation of electrogenic pumps by blue and red light as well as the presence of potassium channels in guard cell plasmalemma. Light activation of electrogenic proton pumping and the ensuing gating of voltage-dependent ion channels appear to be components of sensory transduction of the stomatal response to light. Mechanisms underlying stomatal control by environmental signals can be understood by studying electrical events associated with ion transport. PMID:16667138
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Jammed Humans in High-Density Crowd Disasters
NASA Astrophysics Data System (ADS)
Bottinelli, Arianna; Sumpter, David; Silverberg, Jesse
When people gather in large groups like those found at Black Friday sales events, pilgrimages, heavy metal concerts, and parades, crowd density often becomes exceptionally high. As a consequence, these events can produce tragic outcomes such as stampedes and ''crowd crushes''. While human collective motion has been studied with active particle simulations, the underlying mechanisms for emergent behavior are less well understood. Here, we use techniques developed to study jammed granular materials to analyze an active matter model inspired by large groups of people gathering at a point of common interest. In the model, a single behavioral rule combined with body-contact interactions are sufficient for the emergence of a self-confined steady state, where particles fluctuate around a stable position. Applying mode analysis to this system, we find evidence for Goldstone modes, soft spots, and stochastic resonance, which may be the preferential mechanisms for dangerous emergent collective motions in crowds.
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Control of IP3-mediated Ca2+ puffs in Xenopus laevis oocytes by the Ca2+-binding protein parvalbumin
John, Linu M; Mosquera-Caro, Monica; Camacho, Patricia; Lechleiter, James D
2001-01-01
Elementary events of Ca2+ release (Ca2+ puffs) can be elicited from discrete clusters of inositol 1,4,5 trisphosphate receptors (IP3Rs) at low concentrations of IP3. Ca2+ puffs have rarely been observed unless elicited by either hormone treatment or introduction of IP3 into the cell. However, cells appear to have sufficient concentrations of IP3 (0.1-3.0 μM) to induce Ca2+ release under resting conditions. Here, we investigated Ca2+ puff activity in non-stimulated Xenopus oocytes using confocal microscopy. The fluorescent Ca2+ dye indicators Calcium Green 1 and Oregon Green 488 BAPTA-2 were injected into oocytes to monitor basal Ca2+ activity. In this preparation, injection or overexpression of parvalbumin, an EF-hand Ca2+-binding protein (CaBP), induced Ca2+ puffs in resting Xenopus oocytes. This activity was inhibited by heparin, an IP3R channel blocker, and by mutation of the Ca2+-binding sites in parvalbumin. Ca2+ puff activity was also evoked by injection of low concentrations of the Ca2+ chelator EGTA, but not by calbindin D28k, another member of the EF-hand CaBP superfamily. BAPTA and the Ca2+ indicator dye Oregon Green 488 BAPTA-1 evoked Ca2+ puff activity, while the dextran conjugate of Oregon Green 488 BAPTA-1 did not. These data indicate that a Ca2+ buffer must be mobile in order to increase Ca2+ puff activity. Together, the data indicate that some IP3Rs spontaneously release Ca2+ under resting concentrations of IP3. These elementary Ca2+ events appear to be below the level of detection of current imaging techniques. We suggest that parvalbumin evokes Ca2+ puffs by coordinating the activity of elementary IP3R channel openings. We conclude that Ca2+ release can be evoked not only by hormone-induced increases in IP3, but also by expression of mobile cytosolic CaBPs under resting concentrations of IP3. PMID:11507154
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Should precipitation influence dust emission in global dust models?
NASA Astrophysics Data System (ADS)
Okin, Gregory
2016-04-01
Soil moisture modulates the threshold shear stress required to initiate aeolian transport and dust emission. Most of the theoretical and laboratory work that has confirmed the impact of soil moisture has appropriately acknowledged that it is the soil moisture of a surface layer a few grain diameters thick that truly controls threshold shear velocity. Global and regional models of dust emission include the effect of soil moisture on transport threshold, but most ignore the fact that only the moisture of the very topmost "active layer" matters. The soil moisture in the active layer can differ greatly from that integrated through the top 2, 5, 10, or 100 cm (surface layers used by various global models) because the top 2 mm of heavy texture soils dries within ~1/2 day while sandy soils dry within less than 2 hours. Thus, in drylands where dust emission occurs, it is likely that this top layer is drier than the underlying soil in the days and weeks after rain. This paper explores, globally, the time between rain events in relation to the time for the active layer to dry and the timing of high wind events. This analysis is carried out using the same coarse reanalyses used in global dust models and is intended to inform the soil moisture controls in these models. The results of this analysis indicate that the timing between events is, in almost all dust-producing areas, significantly longer than the drying time of the active layer, even when considering soil texture differences. Further, the analysis shows that the probability of a high wind event during the period after a rain where the surface is wet is small. Therefore, in coarse global models, there is little reason to include rain-derived soil moisture in the modeling scheme.
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Smith, Rebekah E; Bayen, Ute J; Martin, Claudia
2010-01-01
Fifty children 7 years of age (29 girls, 21 boys), 53 children 10 years of age (29 girls, 24 boys), and 36 young adults (19 women, 17 men) performed a computerized event-based prospective memory task. All 3 groups differed significantly in prospective memory performance, with adults showing the best performance and with 7-year-olds showing the poorest performance. We used a formal multinomial process tree model of event-based prospective memory to decompose age differences in cognitive processes that jointly contribute to prospective memory performance. The formal modeling results demonstrate that adults differed significantly from the 7-year-olds and the 10-year-olds on both the prospective component and the retrospective component of the task. The 7-year-olds and the 10-year-olds differed only in the ability to recognize prospective memory target events. The prospective memory task imposed a cost to ongoing activities in all 3 age groups. Copyright 2009 APA, all rights reserved.
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NASA Astrophysics Data System (ADS)
Scafè, Raffaele; Pellegrini, Rosanna; Puccini, Marco; Cinti, Maria N.; Pani, Roberto
2017-10-01
This work deals with the rejection of events interacting more than one time in a crystal array, by using the method introduced in the paper R. Scafè et al. (2016). In particular the grade of symmetry of charge distributions along the X and Y axes was successfully used for discrimination. Results are presented regarding a 10 × 10 LuYAP:Ce array of 2 × 2 × 10mm3 crystal-pixels coupled to a H10966 Hamamatsu 8 × 8 multi-anode assembly under gamma-ray irradiation from a Co-57 radioisotopic source. Filtered pulse-height spectra are shown characterized by relevant rejection of low-amplitude events. In this region of spectrum, asymmetrical charge distributions were measured due to lutetium and yttrium X-rays escape from lateral walls of crystal-pixels. Events from Lu-176 self activity above the Co-57 photoelectric peak were also rejected. Similar results are reasonably expected at PET photon energy.
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ESO Welcomes Finland as Eleventh Member State
NASA Astrophysics Data System (ADS)
Cesarsky, C.
2004-09-01
In early July, Finland joined ESO as the eleventh member state, following the completion of the formal accession procedure. Before this event, however, Finland and ESO had been in contact for a long time. Under an agreement with Sweden, Finnish astronomers had for quite a while enjoyed access to the SEST at La Silla. Finland had also been a very active participant in ESO's educational activities since they began in 1993. It became clear, that science and technology, as well as education, were priority areas for the Finnish government.
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ITER in-vessel system design and performance
NASA Astrophysics Data System (ADS)
Parker, R. R.
2000-03-01
The article reviews the design and performance of the in-vessel components of ITER as developed for the Engineering Design Activities (EDA) Final Design Report. The double walled vacuum vessel is the first confinement boundary and is designed to maintain its integrity under all normal and off-normal conditions, e.g. the most intense vertical displacement events (VDEs) and seismic events. The shielding blanket consists of modules connected to a toroidal backplate by flexible connectors which allow differential displacements due to temperature non-uniformities. Breeding blanket modules replace the shield modules for the Enhanced Performance Phase. The divertor concept is based on a cassette structure which is convenient for remote installation and removal. High heat flux (HHF) components are mechanically attached and can be removed and replaced in the hot cell. Operation of the divertor is based on achieving partially detached plasma conditions along and near the separatrix. Nominal heat loads of 5-10 MW/m2 are expected on the target. These are accommodated by HHF technology developed during the EDA. Disruptions and VDEs can lead to melting of the first wall armour but no damage to the underlying structure. Stresses in the main structural components remain within allowable ranges for all postulated disruption and seismic events.
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Hagman, Arne; Säll, Torbjörn; Compagno, Concetta; Piskur, Jure
2013-01-01
When fruits ripen, microbial communities start a fierce competition for the freely available fruit sugars. Three yeast lineages, including baker's yeast Saccharomyces cerevisiae, have independently developed the metabolic activity to convert simple sugars into ethanol even under fully aerobic conditions. This fermentation capacity, named Crabtree effect, reduces the cell-biomass production but provides in nature a tool to out-compete other microorganisms. Here, we analyzed over forty Saccharomycetaceae yeasts, covering over 200 million years of the evolutionary history, for their carbon metabolism. The experiments were done under strictly controlled and uniform conditions, which has not been done before. We show that the origin of Crabtree effect in Saccharomycetaceae predates the whole genome duplication and became a settled metabolic trait after the split of the S. cerevisiae and Kluyveromyces lineages, and coincided with the origin of modern fruit bearing plants. Our results suggest that ethanol fermentation evolved progressively, involving several successive molecular events that have gradually remodeled the yeast carbon metabolism. While some of the final evolutionary events, like gene duplications of glucose transporters and glycolytic enzymes, have been deduced, the earliest molecular events initiating Crabtree effect are still to be determined.
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Hagman, Arne; Säll, Torbjörn; Compagno, Concetta; Piskur, Jure
2013-01-01
When fruits ripen, microbial communities start a fierce competition for the freely available fruit sugars. Three yeast lineages, including baker’s yeast Saccharomyces cerevisiae, have independently developed the metabolic activity to convert simple sugars into ethanol even under fully aerobic conditions. This fermentation capacity, named Crabtree effect, reduces the cell-biomass production but provides in nature a tool to out-compete other microorganisms. Here, we analyzed over forty Saccharomycetaceae yeasts, covering over 200 million years of the evolutionary history, for their carbon metabolism. The experiments were done under strictly controlled and uniform conditions, which has not been done before. We show that the origin of Crabtree effect in Saccharomycetaceae predates the whole genome duplication and became a settled metabolic trait after the split of the S. cerevisiae and Kluyveromyces lineages, and coincided with the origin of modern fruit bearing plants. Our results suggest that ethanol fermentation evolved progressively, involving several successive molecular events that have gradually remodeled the yeast carbon metabolism. While some of the final evolutionary events, like gene duplications of glucose transporters and glycolytic enzymes, have been deduced, the earliest molecular events initiating Crabtree effect are still to be determined. PMID:23869229
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Neural activations associated with feedback and retrieval success
NASA Astrophysics Data System (ADS)
Wiklund-Hörnqvist, Carola; Andersson, Micael; Jonsson, Bert; Nyberg, Lars
2017-11-01
There is substantial behavioral evidence for a phenomenon commonly called "the testing effect", i.e. superior memory performance after repeated testing compared to re-study of to-be-learned materials. However, considerably less is known about the underlying neuro-cognitive processes that are involved in the initial testing phase, and thus underlies the actual testing effect. Here, we investigated functional brain activity related to test-enhanced learning with feedback. Subjects learned foreign vocabulary across three consecutive tests with correct-answer feedback. Functional brain-activity responses were analyzed in relation to retrieval and feedback events, respectively. Results revealed up-regulated activity in fronto-striatal regions during the first successful retrieval, followed by a marked reduction in activity as a function of improved learning. Whereas feedback improved behavioral performance across consecutive tests, feedback had a negligable role after the first successful retrieval for functional brain-activity modulations. It is suggested that the beneficial effects of test-enhanced learning is regulated by feedback-induced updating of memory representations, mediated via the striatum, that might underlie the stabilization of memory commonly seen in behavioral studies of the testing effect.
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How Does the Sparse Memory “Engram” Neurons Encode the Memory of a Spatial–Temporal Event?
Guan, Ji-Song; Jiang, Jun; Xie, Hong; Liu, Kai-Yuan
2016-01-01
Episodic memory in human brain is not a fixed 2-D picture but a highly dynamic movie serial, integrating information at both the temporal and the spatial domains. Recent studies in neuroscience reveal that memory storage and recall are closely related to the activities in discrete memory engram (trace) neurons within the dentate gyrus region of hippocampus and the layer 2/3 of neocortex. More strikingly, optogenetic reactivation of those memory trace neurons is able to trigger the recall of naturally encoded memory. It is still unknown how the discrete memory traces encode and reactivate the memory. Considering a particular memory normally represents a natural event, which consists of information at both the temporal and spatial domains, it is unknown how the discrete trace neurons could reconstitute such enriched information in the brain. Furthermore, as the optogenetic-stimuli induced recall of memory did not depend on firing pattern of the memory traces, it is most likely that the spatial activation pattern, but not the temporal activation pattern of the discrete memory trace neurons encodes the memory in the brain. How does the neural circuit convert the activities in the spatial domain into the temporal domain to reconstitute memory of a natural event? By reviewing the literature, here we present how the memory engram (trace) neurons are selected and consolidated in the brain. Then, we will discuss the main challenges in the memory trace theory. In the end, we will provide a plausible model of memory trace cell network, underlying the conversion of neural activities between the spatial domain and the temporal domain. We will also discuss on how the activation of sparse memory trace neurons might trigger the replay of neural activities in specific temporal patterns. PMID:27601979
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How Does the Sparse Memory "Engram" Neurons Encode the Memory of a Spatial-Temporal Event?
Guan, Ji-Song; Jiang, Jun; Xie, Hong; Liu, Kai-Yuan
2016-01-01
Episodic memory in human brain is not a fixed 2-D picture but a highly dynamic movie serial, integrating information at both the temporal and the spatial domains. Recent studies in neuroscience reveal that memory storage and recall are closely related to the activities in discrete memory engram (trace) neurons within the dentate gyrus region of hippocampus and the layer 2/3 of neocortex. More strikingly, optogenetic reactivation of those memory trace neurons is able to trigger the recall of naturally encoded memory. It is still unknown how the discrete memory traces encode and reactivate the memory. Considering a particular memory normally represents a natural event, which consists of information at both the temporal and spatial domains, it is unknown how the discrete trace neurons could reconstitute such enriched information in the brain. Furthermore, as the optogenetic-stimuli induced recall of memory did not depend on firing pattern of the memory traces, it is most likely that the spatial activation pattern, but not the temporal activation pattern of the discrete memory trace neurons encodes the memory in the brain. How does the neural circuit convert the activities in the spatial domain into the temporal domain to reconstitute memory of a natural event? By reviewing the literature, here we present how the memory engram (trace) neurons are selected and consolidated in the brain. Then, we will discuss the main challenges in the memory trace theory. In the end, we will provide a plausible model of memory trace cell network, underlying the conversion of neural activities between the spatial domain and the temporal domain. We will also discuss on how the activation of sparse memory trace neurons might trigger the replay of neural activities in specific temporal patterns.
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Dawson, Phillip; Chouet, Bernard
2014-01-01
Eruptive activity returned to the summit region of Kīlauea Volcano, Hawai'i with the formation of the “Overlook crater” within the Halema'uma'u Crater in March 2008. The new crater continued to grow through episodic collapse of the crater walls and as of late 2013 had grown into an approximately elliptical opening with dimensions of ~ 160 × 215 m extending to a depth of ~ 200 m. Occasional weak explosive events and a persistent gas plume continued to occur through 2013. Lava was first observed in the new crater in September 2008, and through 2009 the lava level remained deep in the crater and was only occasionally observed. Since early 2010 a lava lake with fluctuating level within the Overlook crater has been nearly continuously present, and has reached to within 22 m of the Overlook crater rim. Volcanic activity at Kīlauea Volcano is episodic at all time scales and the characterization of very-long-period seismicity in the band 2–100 s for the years 2007–2013 illuminates a portion of this broad spectrum of volcanic behavior. Three types of very-long-period events have been observed over this time and each is associated with distinct processes. Type 1 events are associated with vigorous degassing and occurred primarily between 2007 and 2009. Type 2 events are associated with rockfalls onto the lava lake and occurred primarily after early 2010. Both of these event types are induced by pressure and momentum changes at the top of the magma column that are transmitted downward to a source centroid ~ 1 km below the northeast corner of the Halema'uma'u Crater where the energy couples to the solid Earth at a geometrical discontinuity in the underlying dike system. Type 3 events are not related to surficial phenomena but are associated with transients in mass transfer that occur within the dike system. Very-long-period tremor has also accompanied the return of eruptive activity, with increasing amplitude associated with hours- to months-long changes in gas emission rates and summit deformation.
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Modelling extreme climatic events in Guadalquivir Estuary ( Spain)
NASA Astrophysics Data System (ADS)
Delgado, Juan; Moreno-Navas, Juan; Pulido, Antoine; García-Lafuente, Juan; Calero Quesada, Maria C.; García, Rodrigo
2017-04-01
Extreme climatic events, such as heat waves and severe storms are predicted to increase in frequency and magnitude as a consequence of global warming but their socio-ecological effects are poorly understood, particularly in estuarine ecosystems. The Guadalquivir Estuary has been anthropologically modified several times, the original salt marshes have been transformed to grow rice and cotton and approximately one-fourth of the total surface of the estuary is now part of two protected areas, one of them is a UNESCO, MAB Biosphere Reserve. The climatic events are most likely to affect Europe in forthcoming decades and a further understanding how these climatic disturbances drive abrupt changes in the Guadalquivir estuary is needed. A barotropic model has been developed to study how severe storm events affects the estuary by conducting paired control and climate-events simulations. The changes in the local wind and atmospheric pressure conditions in the estuary have been studied in detail and several scenarios are obtained by running the model under control and real storm conditions. The model output has been validated with in situ water elevation and good agreement between modelled and real measurements have been obtained. Our preliminary results show that the model demonstrated the capability describe of the tide-surge levels in the estuary, opening the possibility to study the interaction between climatic events and the port operations and food production activities. The barotropic hydrodynamic model provide spatially explicit information on the key variables governing the tide dynamics of estuarine areas under severe climatic scenarios . The numerical model will be a powerful tool in future climate change mitigation and adaptation programs in a complex socio-ecological system.
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Chen, Andrew C H; Tang, Yongqiang; Rangaswamy, Madhavi; Wang, Jen C; Almasy, Laura; Foroud, Tatiana; Edenberg, Howard J; Hesselbrock, Victor; Nurnberger, John; Kuperman, Samuel; O'Connor, Sean J; Schuckit, Marc A; Bauer, Lance O; Tischfield, Jay; Rice, John P; Bierut, Laura; Goate, Alison; Porjesz, Bernice
2009-04-05
Evidence suggests the P3 amplitude of the event-related potential and its underlying superimposed event-related oscillations (EROs), primarily in the theta (4-5 Hz) and delta (1-3 Hz) frequencies, as endophenotypes for the risk of alcoholism and other disinhibitory disorders. Major neurochemical substrates contributing to theta and delta rhythms and P3 involve strong GABAergic, cholinergic and glutamatergic system interactions. The aim of this study was to test the potential associations between single nucleotide polymorphisms (SNPs) in glutamate receptor genes and ERO quantitative traits. GRM8 was selected because it maps at chromosome 7q31.3-q32.1 under the peak region where we previously identified significant linkage (peak LOD = 3.5) using a genome-wide linkage scan of the same phenotype (event-related theta band for the target visual stimuli). Neural activities recorded from scalp electrodes during a visual oddball task in which rare target elicited P3s were analyzed in a subset of the Collaborative Study on the Genetics of Alcoholism (COGA) sample comprising 1,049 Caucasian subjects from 209 families (with 472 DSM-IV alcohol dependent individuals). The family-based association test (FBAT) detected significant association (P < 0.05) with multiple SNPs in the GRM8 gene and event-related theta power to target visual stimuli, and also with alcohol dependence, even after correction for multiple comparisons by false discovery rate (FDR). Our results suggest that variation in GRM8 may be involved in modulating event-related theta oscillations during information processing and also in vulnerability to alcoholism. These findings underscore the utility of electrophysiology and the endophenotype approach in the genetic study of psychiatric disorders. (c) 2008 Wiley-Liss, Inc.
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Structural and mechanistic insights into Mps1 kinase activation
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wang, Wei; Yang, Yuting; Gao, Yuefeng
2010-11-05
Mps1 is one of the several essential kinases whose activation is required for robust mitotic spindle checkpoint signalling. The activity of Mps1 is tightly regulated and increases dramatically during mitosis or in response to spindle damage. To understand the molecular mechanism underlying Mps1 regulation, we determined the crystal structure of the kinase domain of Mps1. The 2.7-{angstrom}-resolution crystal structure shows that the Mps1 kinase domain adopts a unique inactive conformation. Intramolecular interactions between the key Glu residue in the {alpha}C helix of the N-terminal lobe and the backbone amides in the catalytic loop lock the kinase in the inactive conformation.more » Autophosphorylation appears to be a priming event for kinase activation. We identified Mps1 autophosphorylation sites in the activation and the P+1 loops. Whereas activation loop autophosphorylation enhances kinase activity, autophosphorylation at the P+1 loop (T686) is associated with the active kinase. Mutation of T686 autophosphorylation site impairs both autophosphorylation and transphosphorylation. Furthermore, we demonstrated that phosphorylation of T676 may be a priming event for phosphorylation at T686. Finally, we identified two critical lysine residues in the loop between helices {alpha}EF and {alpha}F that are essential for substrate recruitment and maintaining high levels of kinase activity. Our studies reveal critical biochemical mechanisms for Mps1 kinase regulation.« less
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Phasic dopamine release drives rapid activation of striatal D2-receptors
Marcott, Pamela F; Mamaligas, Aphroditi A; Ford, Christopher P
2014-01-01
Summary Striatal dopamine transmission underlies numerous goal-directed behaviors. Medium spiny neurons (MSNs) are a major target of dopamine in the striatum. However, as dopamine does not directly evoke a synaptic event in MSNs, the time course of dopamine signaling in these cells remains unclear. To examine how dopamine release activates D2-receptors on MSNs, G-protein activated inwardly rectifying potassium (GIRK2; Kir 3.2) channels were virally overexpressed in the striatum and the resulting outward currents were used as a sensor of D2-receptor activation. Electrical and optogenetic stimulation of dopamine terminals evoked robust D2-receptor inhibitory post-synaptic currents (IPSCs) in GIRK2-expressing MSNs that occurred in under a second. Evoked D2-IPSCs could be driven by repetitive stimulation and were not occluded by background dopamine tone. Together, the results indicate that D2-receptors on MSNs exhibit functional low affinity and suggest that striatal D2-receptors can encode both tonic and phasic dopamine signals. PMID:25242218
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Osaka, Naoyuki; Matsuyoshi, Daisuke; Ikeda, Takashi; Osaka, Mariko
2010-03-10
The recent development of cognitive neuroscience has invited inference about the neurosensory events underlying the experience of visual arts involving implied motion. We report functional magnetic resonance imaging study demonstrating activation of the human extrastriate motion-sensitive cortex by static images showing implied motion because of instability. We used static line-drawing cartoons of humans by Hokusai Katsushika (called 'Hokusai Manga'), an outstanding Japanese cartoonist as well as famous Ukiyoe artist. We found 'Hokusai Manga' with implied motion by depicting human bodies that are engaged in challenging tonic posture significantly activated the motion-sensitive visual cortex including MT+ in the human extrastriate cortex, while an illustration that does not imply motion, for either humans or objects, did not activate these areas under the same tasks. We conclude that motion-sensitive extrastriate cortex would be a critical region for perception of implied motion in instability.
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NASA Astrophysics Data System (ADS)
Stadler, Philipp; Farnleitner, Andreas H.; Sommer, Regina; Kumpan, Monika; Zessner, Matthias
2014-05-01
For the near real time and on-site detection of microbiological fecal pollution of water, the measurement of beta-D- Glucuronidase (GLUC) enzymatic activity has been suggested as a surrogate parameter and has been already successfully operated for water quality monitoring of ground water resources (Ryzinska-Paier et al. 2014). Due to possible short measure intervals of three hours, this method has high potential as a water quality monitoring tool. While cultivation based standard determination takes more than one working day (Cabral 2010) the potential advantage of detecting the GLUC activity is the high temporal measuring resolution. Yet, there is still a big gap of knowledge on the fecal indication capacity of GLUC (specificity, sensitivity, persistence, etc.) in relation to potential pollution sources and catchment conditions (Cabral 2010, Ryzinska-Paier et al. 2014). Furthermore surface waters are a big challenge for automated detection devices in a technical point of view due to the high sediment load during event conditions. This presentation shows results gained form two years of monitoring in an experimental catchment (HOAL) dominated by agricultural land use. Two enzymatic measurement devices are operated parallel at the catchment outlet to test the reproducibility and precision of the method. Data from continuous GLUC monitoring under both base flow and event conditions is compared with reference samples analyzed by standardized laboratory methods for fecal pollution detection (e.g. ISO 16649-1, Colilert18). It is shown that rapid enzymatic on-site GLUC determination can successfully be operated from a technical point of view for surface water quality monitoring under the observed catchment conditions. The comparison of enzyme activity with microbiological standard analytics reveals distinct differences in the dynamic of the signals during event conditions. Cabral J. P. S. (2010) "Water Microbiology. Bacterial Pathogens and Water" International Journal of Environmental Research and Public Health 7 (10): 3657-3703. Ryzinska-Paier, G., T. Lendenfeld, K. Correa, P. Stadler, A.P. Blaschke, R. L. Mach, H. Stadler, AKT Kirschner und A.H. Farnleitner (2014) A sensitive and robust method for automated on-line monitoring of enzymatic activities in water and water resources. Water Sci. Technol. in press
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Intrinsic Patterns of Human Activity
NASA Astrophysics Data System (ADS)
Hu, Kun; Ivanov, Plamen Ch.; Chen, Zhi; Hilton, Michael; Stanley, H. Eugene; Shea, Steven
2003-03-01
Activity is one of the defining features of life. Control of human activity is complex, being influenced by many factors both extrinsic and intrinsic to the body. The most obvious extrinsic factors that affect activity are the daily schedule of planned events, such as work and recreation, as well as reactions to unforeseen or random events. These extrinsic factors may account for the apparently random fluctuations in human motion observed over short time scales. The most obvious intrinsic factors are the body clocks including the circadian pacemaker that influences our sleep/wake cycle and ultradian oscillators with shorter time scales [2, 3]. These intrinsic rhythms may account for the underlying regularity in average activity level over longer periods of up to 24 h. Here we ask if the known extrinsic and intrinsic factors fully account for all complex features observed in recordings of human activity. To this end, we measure activity over two weeks from forearm motion in subjects undergoing their regular daily routine. Utilizing concepts from statistical physics, we demonstrate that during wakefulness human activity possesses previously unrecognized complex dynamic patterns. These patterns of activity are characterized by robust fractal and nonlinear dynamics including a universal probability distribution and long-range power-law correlations that are stable over a wide range of time scales (from minutes to hours). Surprisingly, we find that these dynamic patterns are unaffected by changes in the average activity level that occur within individual subjects throughout the day and on different days of the week, and between subjects. Moreover, we find that these patterns persist when the same subjects undergo time-isolation laboratory experiments designed to account for the phase of the circadian pacemaker, and control the known extrinsic factors by restricting behaviors and manipulating scheduled events including the sleep/wake cycle. We attribute these newly discovered patterns to a robust intrinsic multi-scale dynamic regulation of human activity that is independent of known extrinsic factors, and independent from the circadian and ultradian rhythms.
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Kafoury, Ramzi M; Huang, Ming-Ju
2005-08-01
The sequence of events leading to ozone-induced airway inflammation is not well known. To elucidate the molecular and cellular events underlying ozone toxicity in the lung, we hypothesized that lipid ozonation products (LOPs) generated by the reaction of ozone with unsaturated fatty acids in the epithelial lining fluid and cell membranes play a key role in mediating ozone-induced airway inflammation. To test our hypothesis, we ozonized 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) and generated LOPs. Confluent human bronchial epithelial cells were exposed to the derivatives of ozonized POPC-9-oxononanoyl, 9-hydroxy-9-hydroperoxynonanoyl, and 8-(5-octyl-1,2,4-trioxolan-3-yl-)octanoyl-at a concentration of 10 muM, and the activity of phospholipases A2 (PLA2), C (PLC), and D (PLD) was measured (1, 0.5, and 1 h, respectively). Quantitative structure-activity relationship (QSAR) models were utilized to predict the biological activity of LOPs in airway epithelial cells. The QSAR results showed a strong correlation between experimental and computed activity (r = 0.97, 0.98, 0.99, for PLA2, PLC, and PLD, respectively). The results indicate that QSAR models can be utilized to predict the biological activity of the various ozone-derived LOP species in the lung. Copyright 2005 Wiley Periodicals, Inc.
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Meglič, Andrej; Pecman, Anja; Rozina, Tinkara; Leštan, Domen; Sedmak, Bojan
2017-03-01
Cyanobacterial blooms are global phenomena that can occur in calm and nutrient-rich (eutrophic) fresh and marine waters. Human exposure to cyanobacteria and their biologically active products is possible during water sports and various water activities, or by ingestion of contaminated water. Although the vast majority of harmful cyanobacterial products are confined to the interior of the cells, these are eventually released into the surrounding water following natural or artificially induced cell death. Electrochemical oxidation has been used here to damage cyanobacteria to halt their proliferation, and for microcystin degradation under in-vitro conditions. Partially spent Jaworski growth medium with no addition of supporting electrolytes was used. Electrochemical treatment resulted in the cyanobacterial loss of cell-buoyancy regulation, cell proliferation arrest, and eventual cell death. Microcystin degradation was studied separately in two basic modes of treatment: batch-wise flow, and constant flow, for electrolytic-cell exposure. Batch-wise exposure simulates treatment under environmental conditions, while constant flow is more appropriate for the study of boron-doped diamond electrode efficacy under laboratory conditions. The effectiveness of microcystin degradation was established using high-performance liquid chromatography-photodiode array detector analysis, while the biological activities of the products were estimated using a colorimetric protein phosphatase-1 inhibition assay. The results indicate potential for the application of electro-oxidation methods for the control of bloom events by taking advantage of specific intrinsic ecological characteristics of bloom-forming cyanobacteria. The applicability of the use of boron-doped diamond electrodes in remediation of water exposed to cyanobacteria bloom events is discussed. Copyright © 2016. Published by Elsevier B.V.
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Child mortality, hypothalamic-pituitary-adrenal axis activity and cellular aging in mothers.
Barha, Cindy K; Salvante, Katrina G; Hanna, Courtney W; Wilson, Samantha L; Robinson, Wendy P; Altman, Rachel M; Nepomnaschy, Pablo A
2017-01-01
Psychological challenges, including traumatic events, have been hypothesized to increase the age-related pace of biological aging. Here we test the hypothesis that psychological challenges can affect the pace of telomere attrition, a marker of cellular aging, using data from an ongoing longitudinal-cohort study of Kaqchikel Mayan women living in a population with a high frequency of child mortality, a traumatic life event. Specifically, we evaluate the associations between child mortality, maternal telomere length and the mothers' hypothalamic-pituitary-adrenal axis (HPAA), or stress axis, activity. Child mortality data were collected in 2000 and 2013. HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for seven weeks in 2013. Telomere length (TL) was quantified using qPCR in 55 women from buccal specimens collected in 2013. Shorter TL with increasing age was only observed in women who experienced child mortality (p = 0.015). Women with higher average basal cortisol (p = 0.007) and greater within-individual variation (standard deviation) in basal cortisol (p = 0.053) presented shorter TL. Non-parametric bootstrapping to estimate mediation effects suggests that HPAA activity mediates the effect of child mortality on TL. Our results are, thus, consistent with the hypothesis that traumatic events can influence cellular aging and that HPAA activity may play a mediatory role. Future large-scale longitudinal studies are necessary to confirm our results and further explore the role of the HPAA in cellular aging, as well as to advance our understanding of the underlying mechanisms involved.
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Child mortality, hypothalamic-pituitary-adrenal axis activity and cellular aging in mothers
Barha, Cindy K.; Salvante, Katrina G.; Hanna, Courtney W.; Wilson, Samantha L.; Robinson, Wendy P.; Altman, Rachel M.
2017-01-01
Psychological challenges, including traumatic events, have been hypothesized to increase the age-related pace of biological aging. Here we test the hypothesis that psychological challenges can affect the pace of telomere attrition, a marker of cellular aging, using data from an ongoing longitudinal-cohort study of Kaqchikel Mayan women living in a population with a high frequency of child mortality, a traumatic life event. Specifically, we evaluate the associations between child mortality, maternal telomere length and the mothers’ hypothalamic-pituitary-adrenal axis (HPAA), or stress axis, activity. Child mortality data were collected in 2000 and 2013. HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for seven weeks in 2013. Telomere length (TL) was quantified using qPCR in 55 women from buccal specimens collected in 2013. Results: Shorter TL with increasing age was only observed in women who experienced child mortality (p = 0.015). Women with higher average basal cortisol (p = 0.007) and greater within-individual variation (standard deviation) in basal cortisol (p = 0.053) presented shorter TL. Non-parametric bootstrapping to estimate mediation effects suggests that HPAA activity mediates the effect of child mortality on TL. Our results are, thus, consistent with the hypothesis that traumatic events can influence cellular aging and that HPAA activity may play a mediatory role. Future large-scale longitudinal studies are necessary to confirm our results and further explore the role of the HPAA in cellular aging, as well as to advance our understanding of the underlying mechanisms involved. PMID:28542264
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Evaluating the Eclipse: How good was it?
NASA Astrophysics Data System (ADS)
Noel-Storr, Jacob; InsightSTEM Evaluation Team
2018-01-01
We present findings from the evaluation program carried out of education, public outreach, and communication activities around the "Great American Eclipse" of August 21, 2017. We include findings drawn from the experiences of 30 participants in planning activities prior to the eclipse and 31 recipients of mini-grants for eclipse activities supported by the American Astronomical Society through a grant from the National Science Foundation. We synthesize evaluations gathered by these and other volunteering organizations to provide a multi-site picture of experiences and learning outcomes at eclipse-related events - both in the path of totality and in partial eclipse settings. We make use of qualitative and quantitative responses representing over 30,000 individuals who observed (or tried to observe) the eclipse. We will share findings from across the range of programs included in our evaluation network along with specific highlights. We emphasize a reflection on the motivation and activity behind the 2017 eclipse, and how to leverage the lessons learned for future events on this scale (such as the eclipse of April 8, 2024) along with messages relevant to other events connected with astronomical phenomena, or in multi-site settings.This work was supported in part by the National Science Foundation under Grant No. 1564535 awarded to the American Astronomical Society. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author and do not necessarily reflect the views of the National Science Foundation or the American Astronomical Society.
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Auxin acts as a local morphogenetic trigger to specify lateral root founder cells
Dubrovsky, Joseph G.; Sauer, Michael; Napsucialy-Mendivil, Selene; Ivanchenko, Maria G.; Friml, Jiří; Shishkova, Svetlana; Celenza, John; Benková, Eva
2008-01-01
Plants exhibit an exceptional adaptability to different environmental conditions. To a large extent, this adaptability depends on their ability to initiate and form new organs throughout their entire postembryonic life. Plant shoot and root systems unceasingly branch and form axillary shoots or lateral roots, respectively. The first event in the formation of a new organ is specification of founder cells. Several plant hormones, prominent among them auxin, have been implicated in the acquisition of founder cell identity by differentiated cells, but the mechanisms underlying this process are largely elusive. Here, we show that auxin and its local accumulation in root pericycle cells is a necessary and sufficient signal to respecify these cells into lateral root founder cells. Analysis of the alf4–1 mutant suggests that specification of founder cells and the subsequent activation of cell division leading to primordium formation represent two genetically separable events. Time-lapse experiments show that the activation of an auxin response is the earliest detectable event in founder cell specification. Accordingly, local activation of auxin response correlates absolutely with the acquisition of founder cell identity and precedes the actual formation of a lateral root primordium through patterned cell division. Local production and subsequent accumulation of auxin in single pericycle cells induced by Cre-Lox-based activation of auxin synthesis converts them into founder cells. Thus, auxin is the local instructive signal that is sufficient for acquisition of founder cell identity and can be considered a morphogenetic trigger in postembryonic plant organogenesis. PMID:18559858
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Murine Electrophysiological Models of Cardiac Arrhythmogenesis
2016-01-01
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological processes underlying excitable activity and their tissue propagation as coherent wavefronts from the primary sinoatrial node pacemaker, through the atria, conducting structures and ventricular myocardium. These physiological events are driven by interacting, voltage-dependent, processes of activation, inactivation, and recovery in the ion channels present in cardiomyocyte membranes. Generation and conduction of these events are further modulated by intracellular Ca2+ homeostasis, and metabolic and structural change. This review describes experimental studies on murine models for known clinical arrhythmic conditions in which these mechanisms were modified by genetic, physiological, or pharmacological manipulation. These exemplars yielded molecular, physiological, and structural phenotypes often directly translatable to their corresponding clinical conditions, which could be investigated at the molecular, cellular, tissue, organ, and whole animal levels. Arrhythmogenesis could be explored during normal pacing activity, regular stimulation, following imposed extra-stimuli, or during progressively incremented steady pacing frequencies. Arrhythmic substrate was identified with temporal and spatial functional heterogeneities predisposing to reentrant excitation phenomena. These could arise from abnormalities in cardiac pacing function, tissue electrical connectivity, and cellular excitation and recovery. Triggering events during or following recovery from action potential excitation could thereby lead to sustained arrhythmia. These surface membrane processes were modified by alterations in cellular Ca2+ homeostasis and energetics, as well as cellular and tissue structural change. Study of murine systems thus offers major insights into both our understanding of normal cardiac activity and its propagation, and their relationship to mechanisms generating clinical arrhythmias. PMID:27974512
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Introduction to violent Sun-Earth connection events of October-November 2003
NASA Astrophysics Data System (ADS)
Gopalswamy, N.; Barbieri, L.; Cliver, E. W.; Lu, G.; Plunkett, S. P.; Skoug, R. M.
2005-09-01
The solar-terrestrial events of late October and early November 2003, popularly referred to as the Halloween storms, represent the best observed cases of extreme space weather activity observed to date and have generated research covering multiple aspects of solar eruptions and their space weather effects. In the following article, which serves as an abstract for this collective research, we present highlights taken from 61 of the 74 papers from the Journal of Geophysical Research, Geophysical Research Letters, and Space Weather which are linked under this special issue. (An overview of the 13 associated papers published in Geophysics Research Letters is given in the work of Gopalswamy et al. (2005a)).
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Benson, K.; Estrada, T.; Taufer, M.; Lawrence, J.; Cochran, E.
2011-01-01
The Quake-Catcher Network (QCN) uses low-cost sensors connected to volunteer computers across the world to monitor seismic events. The location and density of these sensors' placement can impact the accuracy of the event detection. Because testing different special arrangements of new sensors could disrupt the currently active project, this would best be accomplished in a simulated environment. This paper presents an accurate and efficient framework for simulating the low cost QCN sensors and identifying their most effective locations and densities. Results presented show how our simulations are reliable tools to study diverse scenarios under different geographical and infrastructural constraints. ?? 2011 IEEE.
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LAN attack detection using Discrete Event Systems.
Hubballi, Neminath; Biswas, Santosh; Roopa, S; Ratti, Ritesh; Nandi, Sukumar
2011-01-01
Address Resolution Protocol (ARP) is used for determining the link layer or Medium Access Control (MAC) address of a network host, given its Internet Layer (IP) or Network Layer address. ARP is a stateless protocol and any IP-MAC pairing sent by a host is accepted without verification. This weakness in the ARP may be exploited by malicious hosts in a Local Area Network (LAN) by spoofing IP-MAC pairs. Several schemes have been proposed in the literature to circumvent these attacks; however, these techniques either make IP-MAC pairing static, modify the existing ARP, patch operating systems of all the hosts etc. In this paper we propose a Discrete Event System (DES) approach for Intrusion Detection System (IDS) for LAN specific attacks which do not require any extra constraint like static IP-MAC, changing the ARP etc. A DES model is built for the LAN under both a normal and compromised (i.e., spoofed request/response) situation based on the sequences of ARP related packets. Sequences of ARP events in normal and spoofed scenarios are similar thereby rendering the same DES models for both the cases. To create different ARP events under normal and spoofed conditions the proposed technique uses active ARP probing. However, this probing adds extra ARP traffic in the LAN. Following that a DES detector is built to determine from observed ARP related events, whether the LAN is operating under a normal or compromised situation. The scheme also minimizes extra ARP traffic by probing the source IP-MAC pair of only those ARP packets which are yet to be determined as genuine/spoofed by the detector. Also, spoofed IP-MAC pairs determined by the detector are stored in tables to detect other LAN attacks triggered by spoofing namely, man-in-the-middle (MiTM), denial of service etc. The scheme is successfully validated in a test bed. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.
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NASA Astrophysics Data System (ADS)
Leckebusch, G.; Ulbrich, U.; Speth, P.
In the context of climate change and the resulting possible impacts on socio-economic conditions for human activities it seems that due to a changed occurrence of extreme events more severe consequences have to be expected than from changes in the mean climate. These extreme events like floods, excessive heats and droughts or windstorms possess impacts on human social and economic life in different categories such as forestry, agriculture, energy use, tourism and the reinsurance business. Reinsurances are affected by nearly 70% of all insured damages over Europe in the case of wind- storms. Especially the December 1999 French windstorms caused damages about 10 billion. A new EU-founded project (MICE = Modelling the Impact of Climate Ex- tremes) will focus on these impacts caused by changed occurrences of extreme events over Europe. Based upon the output of general circulation models as well as regional climate models, investigations are carried out with regard to time series characteristics as well as the spatial patterns of extremes under climate changed conditions. After the definition of specific thresholds for climate extremes, in this talk we will focus on the results of the analysis for the different data sets (HadCM3 and CGCMII GCM's and RCM's, re-analyses, observations) with regard to windstorm events. At first the results of model outputs are validated against re-analyses and observations. Especially a comparison of the stormtrack (2.5 to 8 day bandpass filtered 500 hPa geopotential height), cyclone track, cyclone frequency and intensity is presented. Highly relevant to damages is the extreme wind near the ground level, so the 10 m wind speed will be investigated additionally. of special interest to possible impacts is the changed spatial occurrence of windspeed maxima under 2xCO2-induced climate change.
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Wasatch fault zone, Utah - segmentation and history of Holocene earthquakes
Machette, Michael N.; Personius, Stephen F.; Nelson, Alan R.; Schwartz, David P.; Lund, William R.
1991-01-01
The Wasatch fault zone (WFZ) forms the eastern boundary of the Basin and Range province and is the longest continuous, active normal fault (343 km) in the United States. It underlies an urban corridor of 1.6 million people (80% of Utah's population) representing the largest earthquake risk in the interior of the western United States. The authors have used paleoseismological data to identify 10 discrete segments of the WFZ. Five are active, medial segments with Holocene slip rates of 1-2 mm a-1, recurrence intervals of 2000-4000 years and average lengths of about 50 km. Five are less active, distal segments with mostly pre-Holocene surface ruptures, late Quaternary slip rates of <0.5 mm a-1, recurrence intervals of ???10,000 years and average lengths of about 20 km. Surface-faulting events on each of the medial segments of the WFZ formed 2-4-m-high scarps repeatedly during the Holocene. Paleoseismological records for the past 6000 years indicate that a major surface-rupturing earthquake has occurred along one of the medial segments about every 395 ?? 60 years. However, between about 400 and 1500 years ago, the WFZ experienced six major surface-rupturing events, an average of one event every 220 years, or about twice as often as expected from the 6000-year record. Evidence has been found that surface-rupturing events occurred on the WFZ during the past 400 years, a time period which is twice the average intracluster recurrence interval and equal to the average Holocene recurrence interval.
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Yamanaka, Yasuhiro; Karuppaiah, Kannan; Abu-Amer, Yousef
2011-07-08
The pathologic response to implant wear-debris constitutes a major component of inflammatory osteolysis and remains under intense investigation. Polymethylmethacrylate (PMMA) particles, which are released during implant wear and loosening, constitute a major culprit by virtue of inducing inflammatory and osteolytic responses by macrophages and osteoclasts, respectively. Recent work by several groups has identified important cellular entities and secreted factors that contribute to inflammatory osteolysis. In previous work, we have shown that PMMA particles contribute to inflammatory osteolysis through stimulation of major pathways in monocytes/macrophages, primarily NF-κB and MAP kinases. The former pathway requires assembly of large IKK complex encompassing IKK1, IKK2, and IKKγ/NEMO. We have shown recently that interfering with the NF-κB and MAPK activation pathways, through introduction of inhibitors and decoy molecules, impedes PMMA-induced inflammation and osteolysis in mouse models of experimental calvarial osteolysis and inflammatory arthritis. In this study, we report that PMMA particles activate the upstream transforming growth factor β-activated kinase-1 (TAK1), which is a key regulator of signal transduction cascades leading to activation of NF-κB and AP-1 factors. More importantly, we found that PMMA particles induce TAK1 binding to NEMO and UBC13. In addition, we show that PMMA particles induce TRAF6 and UBC13 binding to NEMO and that lack of TRAF6 significantly attenuates NEMO ubiquitination. Altogether, these observations suggest that PMMA particles induce ubiquitination of NEMO, an event likely mediated by TRAF6, TAK1, and UBC13. Our findings provide important information for better understanding of the mechanisms underlying PMMA particle-induced inflammatory responses.
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Guo, Yi-Peng; Tan, Zhe-Min
2018-04-17
The El Niño-Southern Oscillation (ENSO) can significantly affect the rapid intensification of tropical cyclones over the western North Pacific (WNP). However, ENSO events have various durations, which can lead to different atmospheric and oceanic conditions. Here we show that during short duration El Niño events, the WNP tropical cyclone rapid-intensification mean occurrence position migrates westward by ~8.0° longitude, which is caused by reduced vertical wind shear, increased mid-tropospheric humidity, and enhanced tropical cyclone heat potential over the westernmost WNP. The changes in these factors are caused by westward advected upper ocean heat during the decaying phase of a short duration El Niño. As super El Niño events tend to have short durations and their frequency is projected to increase under global warming, our findings have important implications for future projections of WNP tropical cyclone activity.
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Tagliazucchi, Enzo; Sanjuán, Ana
2017-01-01
Abstract A precise definition of a brain state has proven elusive. Here, we introduce the novel local-global concept of intrinsic ignition characterizing the dynamical complexity of different brain states. Naturally occurring intrinsic ignition events reflect the capability of a given brain area to propagate neuronal activity to other regions, giving rise to different levels of integration. The ignitory capability of brain regions is computed by the elicited level of integration for each intrinsic ignition event in each brain region, averaged over all events. This intrinsic ignition method is shown to clearly distinguish human neuroimaging data of two fundamental brain states (wakefulness and deep sleep). Importantly, whole-brain computational modelling of this data shows that at the optimal working point is found where there is maximal variability of the intrinsic ignition across brain regions. Thus, combining whole brain models with intrinsic ignition can provide novel insights into underlying mechanisms of brain states. PMID:28966977
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Physiological and molecular determinants of embryo implantation
Zhang, Shuang; Lin, Haiyan; Kong, Shuangbo; Wang, Shumin; Wang, Hongmei; Wang, Haibin; Armant, D. Randall
2014-01-01
Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with adverse consequences on later gestation events, highlighting the significance of this event for pregnancy success. Although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk during implantation have been identified through gene expression studies and genetically engineered mouse models, a comprehensive understanding of the nature of embryo implantation is still missing. This review focuses on recent progress with particular attention to physiological and molecular determinants of blastocyst activation, uterine receptivity, blastocyst attachment and uterine decidualization. A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women. PMID:23290997
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Deco, Gustavo; Tagliazucchi, Enzo; Laufs, Helmut; Sanjuán, Ana; Kringelbach, Morten L
2017-01-01
A precise definition of a brain state has proven elusive. Here, we introduce the novel local-global concept of intrinsic ignition characterizing the dynamical complexity of different brain states. Naturally occurring intrinsic ignition events reflect the capability of a given brain area to propagate neuronal activity to other regions, giving rise to different levels of integration. The ignitory capability of brain regions is computed by the elicited level of integration for each intrinsic ignition event in each brain region, averaged over all events. This intrinsic ignition method is shown to clearly distinguish human neuroimaging data of two fundamental brain states (wakefulness and deep sleep). Importantly, whole-brain computational modelling of this data shows that at the optimal working point is found where there is maximal variability of the intrinsic ignition across brain regions. Thus, combining whole brain models with intrinsic ignition can provide novel insights into underlying mechanisms of brain states.
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Zieff, Susan G; Kim, Mi-Sook; Wilson, Jackson; Tierney, Patrick
2014-02-01
Temporary parks such as the monthly event, Sunday Streets SF, support public health goals by using existing infrastructure and street closures to provide physical activity in neighborhoods underserved for recreational resources. Sunday Streets creates routes to enhance community connection. Six hundred and thirty-nine participants at 3 Sunday Streets events were surveyed using a 36-item instrument of open- and closed-ended questions about overall physical activity behavior, physical activity while at Sunday Streets, experience of the events, and demographic data. Overall, Sunday Streets participants are physically active (79% engage in activity 3-7 days/week) and approximately represent the ethnic minority distribution of the city. There were significant differences between first-time attendees and multiple-event attendees by duration of physical activity at the event (55.83 minutes vs. 75.13 minutes) and by frequency of physical activity bouts per week (3.69 vs. 4.22). Both groups emphasized the positive experience and safe environment as reasons to return to the event; for first-time attendees, the social environment was another reason to return. Temporary parks like Sunday Streets have the potential to provide healthful, population-wide physical activity using existing streets. The trend toward increased activity by multiple-event attendees suggests the importance of a regular schedule of events.
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NASA Astrophysics Data System (ADS)
Minati, Ludovico; de Candia, Antonio; Scarpetta, Silvia
2016-07-01
Networks of non-linear electronic oscillators have shown potential as physical models of neural dynamics. However, two properties of brain activity, namely, criticality and metastability, remain under-investigated with this approach. Here, we present a simple circuit that exhibits both phenomena. The apparatus consists of a two-dimensional square lattice of capacitively coupled glow (neon) lamps. The dynamics of lamp breakdown (flash) events are controlled by a DC voltage globally connected to all nodes via fixed resistors. Depending on this parameter, two phases having distinct event rate and degree of spatiotemporal order are observed. The transition between them is hysteretic, thus a first-order one, and it is possible to enter a metastability region, wherein, approaching a spinodal point, critical phenomena emerge. Avalanches of events occur according to power-law distributions having exponents ≈3/2 for size and ≈2 for duration, and fractal structure is evident as power-law scaling of the Fano factor. These critical exponents overlap observations in biological neural networks; hence, this circuit may have value as building block to realize corresponding physical models.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Minati, Ludovico, E-mail: lminati@ieee.org, E-mail: ludovico.minati@unitn.it, E-mail: ludovico.minati@ifj.edu; Complex Systems Theory Department, Institute of Nuclear Physics, Polish Academy of Sciences, Kraków; Candia, Antonio de
2016-07-15
Networks of non-linear electronic oscillators have shown potential as physical models of neural dynamics. However, two properties of brain activity, namely, criticality and metastability, remain under-investigated with this approach. Here, we present a simple circuit that exhibits both phenomena. The apparatus consists of a two-dimensional square lattice of capacitively coupled glow (neon) lamps. The dynamics of lamp breakdown (flash) events are controlled by a DC voltage globally connected to all nodes via fixed resistors. Depending on this parameter, two phases having distinct event rate and degree of spatiotemporal order are observed. The transition between them is hysteretic, thus a first-ordermore » one, and it is possible to enter a metastability region, wherein, approaching a spinodal point, critical phenomena emerge. Avalanches of events occur according to power-law distributions having exponents ≈3/2 for size and ≈2 for duration, and fractal structure is evident as power-law scaling of the Fano factor. These critical exponents overlap observations in biological neural networks; hence, this circuit may have value as building block to realize corresponding physical models.« less
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Koyano, Fumika; Matsuda, Noriyuki
2015-10-01
PINK1 and Parkin are gene products that cause genetic recessive Parkinsonism. PINK1 is a protein kinase and Parkin is a ubiquitin ligase (E3) that links ubiquitin to a substrate. Importantly, under steady state conditions, the enzymatic activity of Parkin is completely suppressed, but is activated when mitochondria become abnormal. In 2013 and 2014, biochemical and structure-function analyses revealed a number of critical mechanistic insights. First, Parkin is a self-inhibitory E3 that suppresses its E3 activity via intramolecular interactions. Second, in response to a decrease in mitochondrial membrane potential, PINK1 phosphorylates Ser65 in both the Parkin ubiquitin-like domain and ubiquitin itself. These phosphorylation events cooperate to relieve the Parkin autoinhibition. Third, activated Parkin forms a ubiquitin-thioester bond at Cys431 to produce a reaction intermediate that catalyzes ubiquitylation of substrates on damaged mitochondria. While the molecular mechanism regulating Parkin enzymatic activity has largely eluded clarification, a complete picture is now emerging. Copyright © 2015 Elsevier B.V. All rights reserved.
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Zinser, Erik R; Schneider, Dominique; Blot, Michel; Kolter, Roberto
2003-01-01
The loss of preexisting genes or gene activities during evolution is a major mechanism of ecological specialization. Evolutionary processes that can account for gene loss or inactivation have so far been restricted to one of two mechanisms: direct selection for the loss of gene activities that are disadvantageous under the conditions of selection (i.e., antagonistic pleiotropy) and selection-independent genetic drift of neutral (or nearly neutral) mutations (i.e., mutation accumulation). In this study we demonstrate with an evolved strain of Escherichia coli that a third, distinct mechanism exists by which gene activities can be lost. This selection-dependent mechanism involves the expropriation of one gene's upstream regulatory element by a second gene via a homologous recombination event. Resulting from this genetic exchange is the activation of the second gene and a concomitant inactivation of the first gene. This gene-for-gene expression tradeoff provides a net fitness gain, even if the forfeited activity of the first gene can play a positive role in fitness under the conditions of selection. PMID:12930738
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Separation of Benign and Malicious Network Events for Accurate Malware Family Classification
2015-09-28
use Kullback - Leibler (KL) divergence [15] to measure the information ...related work in an important aspect concerning the order of events. We use n-grams to capture the order of events, which exposes richer information about...DISCUSSION Using n-grams on higher level network events helps under- stand the underlying operation of the malware, and provides a good feature set
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NASA Astrophysics Data System (ADS)
Wang, L.-C.; Behling, H.; Lee, T.-Q.; Li, H.-C.; Huh, C.-A.; Shiau, L.-J.; Chang, Y.-P.
2014-10-01
We reconstructed paleoenvironmental changes from a sediment archive of a lake in the floodplain of the Ilan Plain of NE Taiwan on multi-decadal resolution for the last ca. 1900 years. On the basis of pollen and diatom records, we evaluated past floods, typhoons, and agricultural activities in this area which are sensitive to the hydrological conditions in the western Pacific. Considering the high sedimentation rates with low microfossil preservations in our sedimentary record, multiple flood events were. identified during the period AD 100-1400. During the Little Ice Age phase 1 (LIA 1 - AD 1400-1620), the abundant occurrences of wetland plant (Cyperaceae) and diatom frustules imply less flood events under stable climate conditions in this period. Between AD 500 and 700 and the Little Ice Age phase 2 (LIA 2 - AD 1630-1850), the frequent typhoons were inferred by coarse sediments and planktonic diatoms, which represented more dynamical climate conditions than in the LIA 1. By comparing our results with the reconstructed changes in tropical hydrological conditions, we suggested that the local hydrology in NE Taiwan is strongly influenced by typhoon-triggered heavy rainfalls, which could be influenced by the variation of global temperature, the expansion of the Pacific warm pool, and the intensification of El Niño-Southern Oscillation (ENSO) events.
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NASA Astrophysics Data System (ADS)
Forte, B.
2012-08-01
Drifting structures characterized by inhomogeneities in the spatial electron density distribution at ionospheric heights cause the scintillation of radio waves propagating through. The fractional electron density fluctuations and the corresponding scintillation levels may reach extreme values at low latitudes during high solar activity. Different levels of scintillation were observed on experimental data collected in the Asian sector at low latitudes by means of a GPS dual frequency receiver under moderate solar activity (2005). The GPS receiver used in these campaigns was particularly modified in firmware in order to record power estimates on the C/A code as well as on the carriers L1 and L2. Strong scintillation activity was recorded in the post-sunset period (saturatingS4 and SI as high as 20 dB). Spectral modifications and broadening was observed during high levels of scintillation possibly indicating refractive scattering taking place instead of diffractive scattering. A possible interpretation of those events was attempted on the basis of the refractive scattering theory developed by Uscinski (1968) and Booker and MajidiAhi (1981).
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Neural principles of memory and a neural theory of analogical insight
NASA Astrophysics Data System (ADS)
Lawson, David I.; Lawson, Anton E.
1993-12-01
Grossberg's principles of neural modeling are reviewed and extended to provide a neural level theory to explain how analogies greatly increase the rate of learning and can, in fact, make learning and retention possible. In terms of memory, the key point is that the mind is able to recognize and recall when it is able to match sensory input from new objects, events, or situations with past memory records of similar objects, events, or situations. When a match occurs, an adaptive resonance is set up in which the synaptic strengths of neurons are increased; thus a long term record of the new input is formed in memory. Systems of neurons called outstars and instars are presumably the underlying units that enable this to occur. Analogies can greatly facilitate learning and retention because they activate the outstars (i.e., the cells that are sampling the to-be-learned pattern) and cause the neural activity to grow exponentially by forming feedback loops. This increased activity insures the boost in synaptic strengths of neurons, thus causing storage and retention in long-term memory (i.e., learning).
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NASA Astrophysics Data System (ADS)
Pistolesi, Marco; Cioni, Raffaello; Rosi, Mauro; Aguilera, Eduardo
2014-02-01
The ice-capped Cotopaxi volcano is known worldwide for the large-scale, catastrophic lahars that have occurred in connection with historical explosive eruptions. The most recent large-scale lahar event occurred in 1877 when scoria flows partially melted ice and snow of the summit glacier, generating debris flows that severely impacted all the river valleys originating from the volcano. The 1877 lahars have been considered in the recent years as a maximum expected event to define the hazard associated to lahar generation at Cotopaxi. Conversely, recent field-based studies have shown that such debris flows have occurred several times during the last 800 years of activity at Cotopaxi, and that the scale of lahars has been variable, including events much larger than that of 1877. Despite a rapid retreat of the summit ice cap over the past century, in fact, there are no data clearly suggesting that future events will be smaller than those observed in the deposits of the last 800 years of activity. In addition, geological field data prove that the lahar triggering mechanism also has to be considered as a key input parameter and, under appropriate eruptive mechanisms, a hazard scenario of a lahar with a volume 3-times larger than the 1877 event is likely. In order to analyze the impact scenarios in the southern drainage system of the volcano, simulations of inundation areas were performed with a semi-empirical model (LAHARZ), using input parameters including variable water volume. Results indicate that a lahar 3-times larger than the 1877 event would invade much wider areas than those flooded by the 1877 lahars along the southern valley system, eventually impacting highly-urbanized areas such as the city of Latacunga.
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R. B. Foltz; N. S. Wagenbrenner
2010-01-01
The assessment teams who make post-fire stabilization and treatment decisions are under pressure to employ more effective and economic post-fire treatments, as wild fire activity and severity has increased in recent years across the western United States. Use of forest-native wood-based materials for hillslope mulching has been on the rise due to potential...
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The Expanding Universe of Astronomy on Tap
NASA Astrophysics Data System (ADS)
Livermore, Rachael C.; Morris, Brett; Narayan, Gautham; Morrison, Sarah J.; Schneider, Evan; Bozek, Brandon; Rice, Emily L.; Hummels, Cameron B.; Garofali, Kristen; Martinez, Raquel; Li, Yuan; Green, Joel D.; LaMassa, Stephanie M.; Silvia, Devin W.; Schwamb, Megan E.; Arcavi, Iair; Silverman, Jeffrey M.
2017-01-01
Astronomy on Tap (AoT) is a constellation of free public outreach presentations held in bars. AoT events aim to engage audiences who might not choose to attend public lectures in a university setting by creating an informal atmosphere and combining scientific talks with music, games, and prizes. The events have a flexible format, typically consisting of between one and three astronomy-related presentations, sometimes with additional games and trivia, and some locations also produce merchandise. The flexible structure means that the format can be adapted to the resources available in the location and the time commitment the local organizers are willing to make. Some events are broadcast online through live streaming, with some others being posted to YouTube. In conjunction with an active social media presence, this ensures engagement beyond those able to attend events in person. Astronomy on Tap events have now been held in 20 cities around the world and are typically organised by postdocs and graduate students, with some involvement from faculty and outreach or education staff. Holding these events under the global AoT constellation facilitates knowledge transfer, sharing of resources, and networking opportunities for scientists interested in outreach/communication. The events have been highly successful, with some locations regularly attracting more than 200 people per month. In this poster we describe the goals and characteristics of AoT events, the different adaptations by various locations, the resources we have developed, and provide information for those interested in starting a new event in their location.
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Mishra, Hemant K; Ma, Jing; Walcheck, Bruce
2017-01-01
Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and robust manner during infection. A cascade of adhesion events direct their attachment to the vascular endothelium and migration into the underlying tissue. A disintegrin and metalloproteinase 17 (ADAM17) functions in the cell membrane of neutrophils and endothelial cells by cleaving its substrates, typically in a cis manner, at an extracellular site proximal to the cell membrane. This process is referred to as ectodomain shedding and it results in the downregulation of various adhesion molecules and receptors, and the release of immune regulating factors. ADAM17 sheddase activity is induced upon cell activation and rapidly modulates intravascular adhesion events in response to diverse environmental stimuli. During sepsis, an excessive systemic inflammatory response against infection, neutrophil migration becomes severely impaired. This involves ADAM17 as indicated by increased levels of its cleaved substrates in the blood of septic patients, and that ADAM17 inactivation improves neutrophil recruitment and bacterial clearance in animal models of sepsis. Excessive ADAM17 sheddase activity during sepsis thus appears to undermine in a direct and indirect manner the necessary balance between intravascular adhesion and de-adhesion events that regulate neutrophil migration into sites of infection. This review provides an overview of ADAM17 function and regulation and its potential contribution to neutrophil dysfunction during sepsis.
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Ortells, Juan J; Kiefer, Markus; Castillo, Alejandro; Megías, Montserrat; Morillas, Alejandro
2016-01-01
The mechanisms underlying masked congruency priming, semantic mechanisms such as semantic activation or non-semantic mechanisms, for example response activation, remain a matter of debate. In order to decide between these alternatives, reaction times (RTs) and event-related potentials (ERPs) were recorded in the present study, while participants performed a semantic categorization task on visible word targets that were preceded either 167 ms (Experiment 1) or 34 ms before (Experiment 2) by briefly presented (33 ms) novel (unpracticed) masked prime words. The primes and targets belonged to different categories (unrelated), or they were either strongly or weakly semantically related category co-exemplars. Behavioral (RT) and electrophysiological masked congruency priming effects were significantly greater for strongly related pairs than for weakly related pairs, indicating a semantic origin of effects. Priming in the latter condition was not statistically reliable. Furthermore, priming effects modulated the N400 event-related potential (ERP) component, an electrophysiological index of semantic processing, but not ERPs in the time range of the N200 component, associated with response conflict and visuo-motor response priming. The present results demonstrate that masked congruency priming from novel prime words also depends on semantic processing of the primes and is not exclusively driven by non-semantic mechanisms such as response activation. Copyright © 2015 Elsevier B.V. All rights reserved.
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Richter, Johannes M.; Abdi-Jalebi, Mojtaba; Sadhanala, Aditya; Tabachnyk, Maxim; Rivett, Jasmine P.H.; Pazos-Outón, Luis M.; Gödel, Karl C.; Price, Michael; Deschler, Felix; Friend, Richard H.
2016-01-01
In lead halide perovskite solar cells, there is at least one recycling event of electron–hole pair to photon to electron–hole pair at open circuit under solar illumination. This can lead to a significant reduction in the external photoluminescence yield from the internal yield. Here we show that, for an internal yield of 70%, we measure external yields as low as 15% in planar films, where light out-coupling is inefficient, but observe values as high as 57% in films on textured substrates that enhance out-coupling. We analyse in detail how externally measured rate constants and photoluminescence efficiencies relate to internal recombination processes under photon recycling. For this, we study the photo-excited carrier dynamics and use a rate equation to relate radiative and non-radiative recombination events to measured photoluminescence efficiencies. We conclude that the use of textured active layers has the ability to improve power conversion efficiencies for both LEDs and solar cells. PMID:28008917
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Richter, Johannes M; Abdi-Jalebi, Mojtaba; Sadhanala, Aditya; Tabachnyk, Maxim; Rivett, Jasmine P H; Pazos-Outón, Luis M; Gödel, Karl C; Price, Michael; Deschler, Felix; Friend, Richard H
2016-12-23
In lead halide perovskite solar cells, there is at least one recycling event of electron-hole pair to photon to electron-hole pair at open circuit under solar illumination. This can lead to a significant reduction in the external photoluminescence yield from the internal yield. Here we show that, for an internal yield of 70%, we measure external yields as low as 15% in planar films, where light out-coupling is inefficient, but observe values as high as 57% in films on textured substrates that enhance out-coupling. We analyse in detail how externally measured rate constants and photoluminescence efficiencies relate to internal recombination processes under photon recycling. For this, we study the photo-excited carrier dynamics and use a rate equation to relate radiative and non-radiative recombination events to measured photoluminescence efficiencies. We conclude that the use of textured active layers has the ability to improve power conversion efficiencies for both LEDs and solar cells.
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NASA Technical Reports Server (NTRS)
Hasegawa, H.; Kitamura, N.; Saito, Y.; Nagai, T.; Shinohara, I.; Yokota, S.; Pollock, C. J.; Giles, B. L.; Dorelli, J. C.; Gershman, D. J.;
2016-01-01
We present observations on 2 October 201Swhen the Geotail spacecraft, near the Earth's equatorial plane, and the Magnetospheric Multiscale (MMS) spacecraft, at mid-southem latitudes, simultaneously encountered southward jets from dayside magnetopause reconnection under southward interplanetary magnetic field conditions. The observations show that the equatorial reconnection site under modest solar wind Alfven Mach number conditions remained active almost continuously for hours and, at the same time, extended over a wide range of local times (4h). The reconnection jets expanded toward the magnetosphere with distance from the reconnection site. Geotall, closer to the reconnection site, occasionally encountered large-amplitude mesoscale flux transfer events (FTEs) with durations about or less than 1 min. However, MMS subsequently detected no or only smaller-amplitude corresponding FTE signatures. It is suggested that during quasi-continuous spatially extended reconnection, mesoscale FTEs decay as the jet spatially evolves over distances between the two spacecraft of 350 ion inertial lengths.
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Davogustto, Giovanni; Higgins, John
2014-11-01
Soccer is the most popular sport in the world, with over 200 million active players. Sudden cardiac death (SCD) represents the most striking as well as the most common cause of death in the soccer field. Underlying cardiovascular pathologies predispose to life threatening ventricular arrhythmias and SCD in soccer players. Up to thousands to hundred thousands players might have an underlying condition that predisposes them for SCD. After several media striking SCD events in soccer players the Fédération Internationale de Football Association (FIFA) has made screening recommendations that are more thorough than the ones recommended for the American Heart Association and the European Society of Cardiology. We present a retrospective search through Internet databases that resulted in 54 soccer players with SCD events from 2000 until 2013. In this article, we will describe and discuss the conditions of those cases of SCD in order to provide more knowledge of the factors that may precipitate SCD in young soccer players.
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Are erosion regimes in SE Australian forests responding to anthropogenic climate change?
NASA Astrophysics Data System (ADS)
Nyman, P.; Rutherfurd, I.; Lane, P. N. J.; Sheridan, G. J.
2017-12-01
In southeast Australia a series of exceptional climate events over the last decade have resulted in widespread debris flow activity across the region. The Millennium Drought (1996-2010), extreme fire-weather and record breaking rainfall in the La Nina year of 2011 have all contributed to an intensification of processes such as runoff production and mass failures that lead to debris flows. Debris flows in landmark locations such as the Grampians and Wilsons Promontory National Parks in 2011 were triggered by mass failure as a result of large volumes of intense summer rainfall. Runoff generated debris flows in burned areas have been occurring regularly and in large numbers along the East Coast Dividing Range from the Warrumbungle Mountains (New South Wales) in the north to Kinglake (Victoria) in the south. In northeast Victoria debris flows have been delivering sediment to the Ovens River following wildfires in 2003, 2007, 2009 and in 2013. The impact of these erosion events on infrastructure, water quality and aquatic ecosystems are considerable and important questions are emerging around i) how frequently events have occurred in the past, ii) the importance of fire as a geomorphic agent, and iii) the effects of climate change on erosion regimes. In this paper we investigate the conditions under which these debris flows occurred, and examine the underlying climatic events in context of historical records. Using data on rainfall distributions and fire history dating back to the 1960s we quantify the frequency with which catchments are primed for extreme erosion events. With these data we begin to speculate on whether or not current catchment conditions (e.g. soil depths, colluvial storage and accumulation rate) is consistent with the erosion regimes we observe. The broader aim of our research is to quantify debris flow thresholds using geophysical response models and use these models to determine the sensitivity of debris flow frequency to climatic forcing. In the presentation we outline a conceptual framework for combining such models with data on past debris flow activity to conduct an attribution study into the effect of anthropogenic climate change on erosion regimes in southeast Australian temperate forests.
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Corey, G Ralph; Loutit, Jeffery; Moeck, Greg; Wikler, Matthew; Dudley, Michael N; O'Riordan, William
2018-04-01
Oritavancin is a lipoglycopeptide with bactericidal activity against Gram-positive organisms. Its rapid concentration-dependent bactericidal activity and long elimination half-life allow single-dose treatment of acute bacterial skin and skin structure infections (ABSSSI). SOLO I and SOLO II were randomized, double-blind studies evaluating the efficacy and safety of a single 1,200-mg intravenous (i.v.) dose of oritavancin versus twice-daily i.v. vancomycin for 7 to 10 days in ABSSSI patients. Safety data from both studies were pooled for safety analysis. The database comprised pooled safety data for 976 oritavancin-treated patients and 983 vancomycin-treated patients. The incidences of adverse events, serious adverse events, and discontinuations due to adverse events were similar for oritavancin (55.3, 5.8, and 3.7%, respectively) and vancomycin (56.9, 5.9, and 4.2%, respectively). The median time to onset (3.8 days versus 3.1 days, respectively) and the duration (3.0 days for both groups) of adverse events were also similar between the two groups. The most frequently reported events were nausea, headache, and vomiting. Greater than 90% of all events were mild or moderate in severity. There were slightly more infections and infestations, abscesses or cellulitis, and hepatic and cardiac adverse events in the oritavancin group; however, more than 80% of these events were mild or moderate. Subgroup analyses did not identify clinically meaningful differences in the incidence of adverse events attributed to oritavancin. A single 1,200-mg dose of oritavancin was well tolerated and had a safety profile similar to that of twice-daily vancomycin. The long elimination half-life of oritavancin compared to that of vancomycin did not result in a clinically meaningful delay to the onset or prolongation of adverse events. (This study has been registered at ClinicalTrials.gov under registration no. NCT01252719 and NCT01252732.). Copyright © 2018 American Society for Microbiology.
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48 CFR 833.213 - Obligation to continue performance.
Code of Federal Regulations, 2013 CFR
2013-10-01
... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...
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48 CFR 833.213 - Obligation to continue performance.
Code of Federal Regulations, 2012 CFR
2012-10-01
... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...
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48 CFR 833.213 - Obligation to continue performance.
Code of Federal Regulations, 2010 CFR
2010-10-01
... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...
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48 CFR 833.213 - Obligation to continue performance.
Code of Federal Regulations, 2014 CFR
2014-10-01
... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...
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48 CFR 833.213 - Obligation to continue performance.
Code of Federal Regulations, 2011 CFR
2011-10-01
... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...
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NASA Technical Reports Server (NTRS)
Steinman, Jeffrey S. (Inventor)
1998-01-01
The present invention is embodied in a method of performing object-oriented simulation and a system having inter-connected processor nodes operating in parallel to simulate mutual interactions of a set of discrete simulation objects distributed among the nodes as a sequence of discrete events changing state variables of respective simulation objects so as to generate new event-defining messages addressed to respective ones of the nodes. The object-oriented simulation is performed at each one of the nodes by assigning passive self-contained simulation objects to each one of the nodes, responding to messages received at one node by generating corresponding active event objects having user-defined inherent capabilities and individual time stamps and corresponding to respective events affecting one of the passive self-contained simulation objects of the one node, restricting the respective passive self-contained simulation objects to only providing and receiving information from die respective active event objects, requesting information and changing variables within a passive self-contained simulation object by the active event object, and producing corresponding messages specifying events resulting therefrom by the active event objects.
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Getzmann, Stephan; Golob, Edward J; Wascher, Edmund
2016-05-01
Speech perception under complex listening conditions usually decreases in aging. This is especially true for listening conditions requiring divided attention among 2 and more relevant speakers. Using a speech perception task and event-related potential measures, we studied the ability of younger and older adults to attend to speech information from a single-target speaker (focused attention) or from 2 different (alternative) target speakers (divided attention). The focused and divided attention conditions were presented either in silence or in the presence of 3 concurrent speakers. In the presence of concurrent speakers, older participants showed worse performance with divided versus focused attention. In contrast, there was no effect of attention condition for the younger adults. Relative to the young, event-related potential analysis in older subjects indicated a decline in preparatory activity for the critical speech information (a delayed and smaller contingent negative variation), and delayed attentional control (indicated by a longer P2 latency). Standardized low-resolution brain electromagnetic tomography revealed that the age-related decline in preparatory activity was associated with reduced activation of medial and superior frontal gyrus and anterior cingulate gyrus. The results suggest that age-related differences in these prefrontal brain areas reflect declines in preparatory attention and gating of subsequent task-related speech information, especially under conditions of divided attention. These findings may reflect mechanisms relating to impaired speech perception by older people in "cocktail-party" listening situations. Copyright © 2016 Elsevier Inc. All rights reserved.
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Characteristics of High Latitude Ionosphere Scintillations
NASA Astrophysics Data System (ADS)
Morton, Y.
2012-12-01
As we enter a new solar maximum period, global navigation satellite systems (GNSS) receivers, especially the ones operating in high latitude and equatorial regions, are facing an increasing threat from ionosphere scintillations. The increased solar activities, however, also offer a great opportunity to collect scintillation data to characterize scintillation signal parameters and ionosphere irregularities. While there are numerous GPS receivers deployed around the globe to monitor ionosphere scintillations, most of them are commercial receivers whose signal processing mechanisms are not designed to operate under ionosphere scintillation. As a result, they may distort scintillation signal parameters or lose lock of satellite signals under strong scintillations. Since 2008, we have established and continuously improved a unique GNSS receiver array at HAARP, Alaska. The array contains high ends commercial receivers and custom RF front ends which can be automatically triggered to collect high quality GPS and GLONASS satellite signals during controlled heating experiments and natural scintillation events. Custom designed receiver signal tracking algorithms aim to preserve true scintillation signatures are used to process the raw RF samples. Signal strength, carrier phase, and relative TEC measurements generated by the receiver array since its inception have been analyzed to characterize high latitude scintillation phenomena. Daily, seasonal, and solar events dependency of scintillation occurrence, spectral contents of scintillation activities, and plasma drifts derived from these measurements will be presented. These interesting results demonstrate the feasibility and effectiveness of our experimental data collection system in providing insightful details of ionosphere responses to active perturbations and natural disturbances.
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NASA Astrophysics Data System (ADS)
Menendez, H. M.; Thurber, C. H.
2011-12-01
Eastern California's Long Valley Caldera (LVC) and the Mono-Inyo Crater volcanic systems have been active for the past ~3.6 million years. Long Valley is known to produce very large silicic eruptions, the last of which resulted in the formation of a 17 km by 32 km wide, east-west trending caldera. Relatively recent unrest began between 1978-1980 with five ML ≥ 5.7 non-double-couple (NDC) earthquakes and associated aftershock swarms. Similar shallow seismic swarms have continued south of the resurgent dome and beneath Mammoth Mountain, surrounding sites of increased CO2 gas emissions. Nearly two decades of increased volcanic activity led to the 1997 installation of a temporary three-component array of 69 seismometers. This network, deployed by the Durham University, the USGS, and Duke University, recorded over 4,000 high-frequency events from May to September. A local tomographic inversion of 283 events surrounding Mammoth Mountain yielded a velocity structure with low Vp and Vp/Vs anomalies at 2-3 km bsl beneath the resurgent dome and Casa Diablo hot springs. These anomalies were interpreted to be CO2 reservoirs (Foulger et al., 2003). Several teleseismic and regional tomography studies have also imaged low Vp anomalies beneath the caldera at ~5-15 km depth, interpreted to be the underlying magma reservoir (Dawson et al., 1990; Weiland et al., 1995; Thurber et al., 2009). This study aims to improve the resolution of the LVC regional velocity model by performing tomographic inversions using the local events from 1997 in conjunction with regional events recorded by the Northern California Seismic Network (NCSN) between 1980 and 2010 and available refraction data. Initial tomographic inversions reveal a low velocity zone at ~2 to 6 km depth beneath the caldera. This structure may simply represent the caldera fill. Further iterations and the incorporation of teleseismic data may better resolve the overall shape and size of the underlying magma reservoir.
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Draberova, Lubica; Paulenda, Tomas; Halova, Ivana; Potuckova, Lucie; Bugajev, Viktor; Bambouskova, Monika; Tumova, Magda; Draber, Petr
2015-01-01
Ethanol has multiple effects on biochemical events in a variety of cell types, including the high-affinity immunoglobulin E receptor (FcεRI) signaling in antigen-activated mast cells. However, the underlying molecular mechanism remains unknown. To get better understanding of the effect of ethanol on FcεRI-mediated signaling we examined the effect of short-term treatment with non-toxic concentrations of ethanol on FcεRI signaling events in mouse bone marrow-derived mast cells. We found that 15 min exposure to ethanol inhibited antigen-induced degranulation, calcium mobilization, expression of proinflammatory cytokine genes (tumor necrosis factor-α, interleukin-6, and interleukin-13), and formation of reactive oxygen species in a dose-dependent manner. Removal of cellular cholesterol with methyl-β-cyclodextrin had a similar effect and potentiated some of the inhibitory effects of ethanol. In contrast, exposure of the cells to cholesterol-saturated methyl-β-cyclodextrin abolished in part the inhibitory effect of ethanol on calcium response and production of reactive oxygen species, supporting lipid-centric theories of ethanol action on the earliest stages of mast cell signaling. Further studies showed that exposure to ethanol and/or removal of cholesterol inhibited early FcεRI activation events, including tyrosine phosphorylation of the FcεRI β and γ subunits, SYK kinases, LAT adaptor protein, phospholipase Cγ, STAT5, and AKT and internalization of aggregated FcεRI. Interestingly, ethanol alone, and particularly in combination with methyl-β-cyclodextrin, enhanced phosphorylation of negative regulatory tyrosine 507 of LYN kinase. Finally, we found that ethanol reduced passive cutaneous anaphylactic reaction in mice, suggesting that ethanol also inhibits FcεRI signaling under in vivo conditions. The combined data indicate that ethanol interferes with early antigen-induced signaling events in mast cells by suppressing the function of FcεRI-cholesterol signalosomes at the plasma membrane. PMID:26658290
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Characterization of the MCM homohexamer from the thermoacidophilic euryarchaeon Picrophilus torridus
Goswami, Kasturi; Arora, Jasmine; Saha, Swati
2015-01-01
The typical archaeal MCM exhibits helicase activity independently in vitro. This study characterizes MCM from the euryarchaeon Picrophilus torridus. While PtMCM hydrolyzes ATP in DNA-independent manner, it displays very poor ability to unwind DNA independently, and then too only under acidic conditions. The protein exists stably in complex with PtGINS in whole cell lysates, interacting directly with PtGINS under neutral and acidic conditions. GINS strongly activates MCM helicase activity, but only at low pH. In consonance with this, PtGINS activates PtMCM-mediated ATP hydrolysis only at low pH, with the amount of ATP hydrolyzed during the helicase reaction increasing more than fifty-fold in the presence of GINS. While the stimulation of MCM-mediated helicase activity by GINS has been reported in MCMs from P.furiosus, T.kodakarensis, and very recently, T.acidophilum, to the best of our knowledge, this is the first report of an MCM helicase demonstrating DNA unwinding activity only at such acidic pH, across all archaea and eukaryotes. PtGINS may induce/stabilize a conducive conformation of PtMCM under acidic conditions, favouring PtMCM-mediated DNA unwinding coupled to ATP hydrolysis. Our findings underscore the existence of divergent modes of replication regulation among archaea and the importance of investigating replication events in more archaeal organisms. PMID:25762096
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Influence of a water regulation event on the age of Yellow River water in the Bohai
NASA Astrophysics Data System (ADS)
Li, Zhen; Wang, Haiyan; Guo, Xinyu; Liu, Zhe; Gao, Huiwang; Zhang, Guiling
2017-10-01
Abrupt changes in freshwater inputs from large rivers usually imply regime shifts in coastal water environments. The influence of a water regulation event on the age of the Yellow River water in the Bohai was modeled using constituent-oriented age and residence time theory to better understand the change in the environmental function of the hydrodynamic field owing to human activities. The water ages in Laizhou Bay, the central basin, and the Bohai strait are sensitive to water regulation. The surface ages in those areas can decrease by about 300 days, particularly in July, and the age stratification is also strengthened. A water regulation event can result in declines in the water age in early July ahead of declines in the water age under climatological conditions (without the regulation event) by about 1 and 5 months in the central basin and Laizhou Bay, respectively. The change in the coastal circulation due to the water regulation event is the primary reason for the change in the Yellow River water age. The high Yellow River flow rate can enhance the density flow and, therefore, reduce the age of the Yellow River water. The subsequent impact of a single water regulation event can last about 1.0 to 4.0 years in different subregions.
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Effects of cues to event segmentation on subsequent memory.
Gold, David A; Zacks, Jeffrey M; Flores, Shaney
2017-01-01
To remember everyday activity it is important to encode it effectively, and one important component of everyday activity is that it consists of events. People who segment activity into events more adaptively have better subsequent memory for that activity, and event boundaries are remembered better than event middles. The current study asked whether intervening to improve segmentation by cuing effective event boundaries would enhance subsequent memory for events. We selected a set of movies that had previously been segmented by a large sample of observers and edited them to provide visual and auditory cues to encourage segmentation. For each movie, cues were placed either at event boundaries or event middles, or the movie was left unedited. To further support the encoding of our everyday event movies, we also included post-viewing summaries of the movies. We hypothesized that cuing at event boundaries would improve memory, and that this might reduce age differences in memory. For both younger and older adults, we found that cuing event boundaries improved memory-particularly for the boundaries that were cued. Cuing event middles also improved memory, though to a lesser degree; this suggests that imposing a segmental structure on activity may facilitate memory encoding, even when segmentation is not optimal. These results provide evidence that structural cuing can improve memory for everyday events in younger and older adults.
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Free Language Selection in the Bilingual Brain: An Event-Related fMRI Study
Zhang, Yong; Wang, Tao; Huang, Peiyu; Li, Dan; Qiu, Jiang; Shen, Tong; Xie, Peng
2015-01-01
Bilingual speakers may select between two languages either on demand (forced language selection) or on their own volition (free language selection). However, the neural substrates underlying free and forced language selection may differ. While the neural substrates underlying forced language selection have been well-explored with language switching paradigms, those underlying free language selection have remained unclear. Using a modified digit-naming switching paradigm, we addressed the neural substrates underlying free language selection by contrasting free language switching with forced language switching. For a digit-pair trial, Chinese-English bilinguals named each digit in Chinese or English either on demand under forced language selection condition or on their own volition under free language selection condition. The results revealed activation in the frontoparietal regions that mediate volition of language selection. Furthermore, a comparison of free and forced language switching demonstrated differences in the patterns of brain activation. Additionally, free language switching showed reduced switching costs as compared to forced language switching. These findings suggest differences between the mechanism(s) underlying free and forced language switching. As such, the current study suggests interactivity between control of volition and control of language switching in free language selection, providing insights into a model of bilingual language control. PMID:26177885
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Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease
Dufek, Brianna; Meehan, Daniel; Delimont, Duane; Cheung, Linda; Gratton, Michael Anne; Phillips, Grady; Song, Wenping; Liu, Shiguang; Cosgrove, Dominic
2016-01-01
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the sub-capillary spaces by mesangial filopodia. The filopodia deposit mesangial matrix proteins in the glomerular basement membrane, including laminin 211, which activates focal adhesion kinase in podocytes culminating in the up-regulation of pro-inflammatory cytokines and metalloproteinases. These events drive the progression of glomerulonephritis. Here we test whether endothelial cell-derived endothelin-1 is upregulated in Alport glomeruli, and further elevated by hypertension. Treatment of cultured mesangial cells with endothelin-1 activates the formation of drebrin-positive actin microspikes. These microspikes do not form when cells are treated with the endothelin A receptor antagonist sitaxentan, or under conditions of siRNA knockdown of endothelin A receptor mRNA. Treatment of Alport mice with sitaxentan results in delayed onset of proteinuria, normalized glomerular basement membrane morphology, inhibition of mesangial filopodial invasion of the glomerular capillaries, normalization of glomerular expression of metalloproteinases and pro-inflammatory cytokines, increased lifespan, and prevention of glomerulosclerosis and interstitial fibrosis. Thus endothelin A receptor activation on mesangial cells is a key event in initiation of Alport glomerular disease in this model. PMID:27165837
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Surviving collapsed structure entrapment after earthquakes: a "time-to-rescue" analysis.
Macintyre, Anthony G; Barbera, Joseph A; Smith, Edward R
2006-01-01
Massive earthquakes often cause structures to collapse, trapping victims under dense rubble for long periods of time. Commonly, this spurs resource intensive, dangerous, and frustrating attempts to find and extricate live victims. The search and rescue phase usually is maintained for many days beyond the last "save," potentially diverting critical attention and resources away from the pressing needs of non-trapped survivors and the devastated community. This recurring phenomenon is driven by the often-unanswered question "Can anyone still be alive under there?" The maximum survival time in entrapment is an important issue for responders, yet little formal research has been conducted on this issue. Knowing the maximum survival time in entrapment helps responders: (1) decide whether or not they should continue to assign limited resources to search and rescue activities; (2) assess the safety risks versus the benefits; (3) determine when search and rescue activities no longer are indicated; and (4) time and pace the important transition to community recovery efforts. The time period of 1985-2004 was selected for investigation. Medline and Lexis-Nexis databases were searched for earthquake events that occurred within this timeframe. Medical literature articles providing time-torescue data for victims of earthquakes were identified. Lexis-Nexis reports were scanned to select those with time-to-rescue data for victims of earthquakes. Reports from both databases were examined for information that might contribute to prolonged survival of entrapped individuals. A total of 34 different earthquake events met study criteria. Forty-eight medical articles containing time-to-rescue data were identified. Of these, the longest time to rescue was "13-19 days" post-event (secondhand data and the author is not specific). The second longest time to rescue in the medical articles was 8.7 days (209 hours). Twenty-five medical articles report multiple rescues that occurred after two days (48 hours). Media reports describe rescues occurring beyond Day 2 in 18 of 34 earthquakes. Of these, the longest reliably reported survival is 14 days after impact, with the next closest having survived 13 days. The average maximum times reported from these 18 earthquakes was 6.8 days (median = 5.75 days). The event with the most media reports of distinct rescue events was the 1999 Marmara, Turkey earthquake (43 victims). Times range from 0.5 days (12 hours) to 6.2 days (146 hours) for this event. Both databases provide little formal data to develop detailed insight into factors affecting survivability during entrapment. A thorough search of the English-language medical literature and media accounts provides a provocative picture of numerous survivors beyond 48 hours of entrapment under rubble, with a few successfully enduring entrapment of 13-14 days. These data are not necessarily applicable to non-earthquake collapsed-structure events. For incident managers and their medical advisors, the study findings and discussion may be useful for post-impact decision-making and in establishing and/or revising incident priorities as the response evolves.
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Echterhoff, Gerald; Wolf, Oliver T.
2012-01-01
Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic) arousal and post-event stress interact to selectively enhance eyewitnesses' memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (1) the stimuli are encoded under arousal (vs. non-arousal), and (2) stress is experienced soon after the encoding episode. We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test (TSST). Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant post-event stress × thematic arousal × centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation. PMID:22936900
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Echterhoff, Gerald; Wolf, Oliver T
2012-01-01
Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic) arousal and post-event stress interact to selectively enhance eyewitnesses' memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (1) the stimuli are encoded under arousal (vs. non-arousal), and (2) stress is experienced soon after the encoding episode. We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test (TSST). Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant post-event stress × thematic arousal × centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation.
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Ocean waves from tropical cyclones in the Gulf of Mexico and the effect of climate change
NASA Astrophysics Data System (ADS)
Appendini, C. M.; Pedrozo-Acuña, A.; Meza-Padilla, R.; Torres-Freyermuth, A.; Cerezo-Mota, R.; López-González, J.
2016-12-01
To generate projections of wave climate associated to tropical cyclones is a challenge due to their short historical record of events, their low occurrence, and the poor wind field resolution in General Circulation Models. Synthetic tropical cyclones provide an alternative to overcome such limitations, improving robust statistics under present and future climates. We use synthetic events to characterize present and future wave climate associated with tropical cyclones in the Gulf of Mexico. The NCEP/NCAR atmospheric reanalysis and the Coupled Model Intercomparison Project Phase 5 models NOAA/GFDL CM3 and UK Met Office HADGEM2-ES, were used to derive present and future wave climate under RCPs 4.5 and 8.5. The results suggest an increase in wave activity for the future climate, particularly for the GFDL model that shows less bias in the present climate, although some areas are expected to decrease the wave energy. The practical implications of determining the future wave climate is exemplified by means of the 100-year design wave, where the use of the present climate may result in under/over design of structures, since the lifespan of a structure includes the future wave climate period.
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NASA Astrophysics Data System (ADS)
Oltmans, S. J.; Schnell, R. C.; Mefford, T. K.; Neely, R. R., III
2012-12-01
The wintertime cold, reduced sunlight conditions of the mid-latitudes of continental interior locations are normally not considered to be conducive to significant ozone production. Recent observations have shattered this expectation with hourly ozone mixing ratios regularly exceeding 100 ppb measured in January, February and March in the states of Wyoming and Utah in the United States. Maximum daily eight hour average ozone mixing ratios have exceeded 100 ppb, far exceeding the U.S. threshold of 75 ppb. Conditions under which this dramatic ozone production takes place include a mix of high levels of ozone precursors (NOx and VOCs), a very stable and shallow boundary layer, snow cover providing enhanced UV radiation, and air confining terrain features. The high levels of precursors have been tied to oil and gas extraction activities in the affected regions. Under the requisite meteorological conditions where high pressure, low winds, and snow-covered ground are present extremely stable and shallow (~50-200 m) boundary layers persist. The highly reflective snow cover provides enhanced photolysis rates that in February can exceed those in June. For several winters in Utah and Wyoming with large ozone enhancements, the time series of various meteorological (wind, temperature, solar radiation, snow cover) and chemical parameters (ozone and NOx) show a somewhat different progression of high ozone events between the two locations. In the Unitah Basin of Utah high ozone formation conditions are more persistent throughout the winter than in the Pinedale Anticline region of Wyoming. This is likely a function of the differing topography of the two areas. However, for individual events the two sites show a similar progression of rapid ozone formation each day. Sites in both Utah and Wyoming just outside the oil and gas extraction activity areas show little or no enhanced ozone. Winters without the requisite meteorological conditions also do not experience high ozone events.
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NASA Astrophysics Data System (ADS)
Viereck, R. A.; Azeem, S. I.
2017-12-01
One of the goals of the National Space Weather Action Plan is to establish extreme event benchmarks. These benchmarks are estimates of environmental parameters that impact technologies and systems during extreme space weather events. Quantitative assessment of anticipated conditions during these extreme space weather event will enable operators and users of affected technologies to develop plans for mitigating space weather risks and improve preparedness. The ionosphere is one of the most important regions of space because so many applications either depend on ionospheric space weather for their operation (HF communication, over-the-horizon radars), or can be deleteriously affected by ionospheric conditions (e.g. GNSS navigation and timing, UHF satellite communications, synthetic aperture radar, HF communications). Since the processes that influence the ionosphere vary over time scales from seconds to years, it continues to be a challenge to adequately predict its behavior in many circumstances. Estimates with large uncertainties, in excess of 100%, may result in operators of impacted technologies over or under preparing for such events. The goal of the next phase of the benchmarking activity is to reduce these uncertainties. In this presentation, we will focus on the sources of uncertainty in the ionospheric response to extreme geomagnetic storms. We will then discuss various research efforts required to better understand the underlying processes of ionospheric variability and how the uncertainties in ionospheric response to extreme space weather could be reduced and the estimates improved.
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The influence of the mining operation on the mine seismicity of Vorkuta coal deposit
NASA Astrophysics Data System (ADS)
Zmushko, T.; Turuntaev, S. B.; Kulikov, V. I.
2012-04-01
The mine seismicity of Vorkuta coal deposit was analyzed. Seismic network consisting of 24 seismic sensors (accelerometers) cover the area of "Komsomolskaya" and "North" mines of Vorkuta deposit. Also there is seismic station of IDG RAS with three-component seismometer near this mines for better defining energy of the seismic events. The catalogs of seismic events contain 9000 and 7000 events with maximum magnitude M=2.3 for "Komsomolskaya" and "North" mines respectively and include the period from 01.09.2008 to 01.09.2011. The b-value of the magnitude-frequency relation was -1.0 and -1.15 respectively for the mines, meanwhile b-value for the nature seismicity was -0,9. It was found, that the number of seismic events per hour during mine combine operation is higher in 2.5 times than the number of seismic events during the break in the operation. Also, the total energy of the events per hour during the operation is higher in 3-5 times than during the break. The study showed, that the number and the energy of the seismic events relate with the hours of mine combine operation. The spatial distribution of the seismic events showed, that 80% of all events and 85% of strong events (M>1.6) were located in and near the longwall under development during the mine combine operations as well asduring the breaks. The isoclines of seismic event numbers proved that the direction of motion of the boundary of seismic events extension coincides with the direction of development, the maximum number of events for any period lies within the wall under operation. The rockburst with M=2.3 occurring at the North mine at July 16, 2011 was considered. The dependences of the energy and of the number of events with different magnitudes on the time showed that the number of events with M=1 and especially M=0.5 before the rockburst decreased, which corresponds to the prognostic seismic quietness, described in the research works. The spatial distribution of the events for the 6 month before the rockburst showed that the rockbust occurred at some distance from the main group of seismic events, in an area where the vent brake slope was made at that time. It was found that there is an area where the coal was not developed, but the seismic events occured. Such area could be noticed before the moment of the rockburst. The spatial distribution of the seismic events during the "seismic quietness" showed that for events with M = 1, and especially for the events with M = 0.5, the analogue of "seismic gap" (the area without events between the seismically active areas) can be noticed. The rockburst occurred at the boundary of the "seismic gap". Obtained results (which are in correspondence with known natural earthquake prediction phenomena) could be used for forecast of the considered rockburst in a 1 month before it occurred.
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26 CFR 54.4980B-3 - Qualified beneficiaries.
Code of Federal Regulations, 2012 CFR
2012-04-01
... qualified beneficiary is— (i) Any individual who, on the day before a qualifying event, is covered under a... qualifying event that is the bankruptcy of the employer, a covered employee who had retired on or before the... bankruptcy qualifying event, the spouse, surviving spouse, or dependent child is a beneficiary under the plan...
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26 CFR 54.4980B-3 - Qualified beneficiaries.
Code of Federal Regulations, 2013 CFR
2013-04-01
... qualified beneficiary is— (i) Any individual who, on the day before a qualifying event, is covered under a... qualifying event that is the bankruptcy of the employer, a covered employee who had retired on or before the... bankruptcy qualifying event, the spouse, surviving spouse, or dependent child is a beneficiary under the plan...
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Equinoctial Activity Over Titan Dune Fields Revealed by Cassini/vims
NASA Astrophysics Data System (ADS)
Rodriguez, S.; Le Mouelic, S.; Barnes, J. W.; Hirtzig, M.; Rannou, P.; Sotin, C.; Brown, R. H.; Bow, J.; Vixie, G.; Cornet, T.; Bourgeois, O.; Narteau, C.; Courrech Du Pont, S.; Le Gall, A.; Reffet, E.; Griffith, C. A.; Jaumann, R.; Stephan, K.; Buratti, B. J.; Clark, R. N.; Baines, K. H.; Nicholson, P. D.; Coustenis, A.
2012-12-01
Titan, the largest satellite of Saturn, is the only satellite in the solar system with a dense atmosphere. The close and continuous observations of Titan by the Cassini spacecraft, in orbit around Saturn since July 2004, bring us evidences that Titan troposphere and low stratosphere experience an exotic, but complete meteorological cycle similar to the Earth hydrological cycle, with hydrocarbons evaporation, condensation in clouds, and rainfall. Cassini monitoring campaigns also demonstrate that Titan's cloud coverage and climate vary with latitude. Titan's tropics, with globally weak meteorological activity and widespread dune fields, seem to be slightly more arid than the poles, where extensive and numerous liquid reservoirs and sustained cloud activity have been discovered. Only a few tropo-spheric clouds have been observed at Titan's tropics during the southern summer. As equinox was approaching (in August 2009), they occurred more frequently and appeared to grow in strength and size. We present here the observation of intense brightening at Titan's tropics, very close to the equinox. These detections were conducted with the Visual and Infrared Mapping Spectrometer (VIMS) onboard Cassini. We will discuss the VIMS images of the three individual events detected so far, observed during the Titan's flybys T56 (22 May 2009), T65 (13 January 2010) and T70 (21 June 2010). T56, T65 and T70 observations show an intense and transient brighten-ing of large regions very close to the equator, right over the extensive dune fields of Senkyo, Belet and Shangri-La. They all appear spectrally and morphologically different from all transient surface features or atmospheric phenomena previously reported. Indeed, these events share in particular a strong brightening at wavelengths greater than 2 μm (especially at 5 μm), making them spectrally distinct from the small tropical clouds observed before the equinox and the large storms observed near the equator in September and October 2010. In this paper, we will discuss the possibility that these singular events may have occurred very close to the surface, having a strong link with the underlying dune fields. Radiative transfer calculations indeed show that these singular brightenings are due to the transient appearance of an additional atmospheric layer, confined at very low altitudes and loaded with few but large particles. Gathering all the observational and modeling constraints, we conclude that the most probable explanation for these events is the local and transient occurrence of huge sand storms, directly originating from the underlying dune fields. We will also discuss the possible implications of the equinoctial occurrence of such events for Titan's tropical wind regimes and for the present-day activity of equatorial dunes.
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NASA Astrophysics Data System (ADS)
Zhao, H.; Baker, D. N.; Califf, S.; Li, X.; Jaynes, A. N.; Leonard, T.; Kanekal, S. G.; Blake, J. B.; Fennell, J. F.; Claudepierre, S. G.; Turner, D. L.; Reeves, G. D.; Spence, H. E.
2017-12-01
Using measurements from the Van Allen Probes, a penetration event of tens to hundreds of keV electrons and tens of keV protons into the low L shells (L < 4) is studied. Timing and magnetic local time (MLT) differences of energetic particle deep penetration are unveiled and underlying physical processes are examined. During this event, both proton and electron penetrations are MLT asymmetric. The observed MLT difference of proton penetration is consistent with convection of plasma sheet protons, suggesting enhanced convection during geomagnetic active times to be the cause of energetic proton deep penetration during this event. The observed MLT difference of tens to hundreds of keV electron penetration is completely different from tens of keV protons and cannot be well explained by inward radial diffusion, convection of plasma sheet electrons, or transport of trapped electrons by enhanced convection electric field represented by the Volland-Stern model or a uniform dawn-dusk electric field model based on the electric field measurements. It suggests that the underlying physical mechanism responsible for energetic electron deep penetration, which is very important for fully understanding energetic electron dynamics in the low L shells, should be MLT localized.
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Farmer, Shu; Mindry, Deborah; Comulada, W Scott; Swendeman, Dallas
Stressful life events and daily hassles affect people living with HIV (PLWH). However, capturing stress-related events and cognitive impairment is often plagued with recall biases. Incorporating reliable information technology, such as mobile phones, can be a resourceful method for measuring health behaviors (MHB). We report findings from an MHB pilot study with 32 African American, Latino/Hispanic, and White PLWH from Los Angeles. Participants reported perceived stressors in their daily routines using a smartphone Ecological Momentary Assessment (EMA) application. Participants self-initiated in-the-moment stressful events reports for up to 6 weeks. Stressful event EMAs queried perceived stress levels (1-10 scale) and open-ended text descriptions. Qualitative analysis of participant text responses was completed using grounded thematic coding. Participants reported multiple stressors in their daily routines, impacting activities of daily living or daily functioning. Eliciting input from PLWH via EMA in real time is a novel approach for assessing and identifying sources of stress. Copyright © 2017 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.
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Shaping Social Activity by Incentivizing Users
Farajtabar, Mehrdad; Du, Nan; Rodriguez, Manuel Gomez; Valera, Isabel; Zha, Hongyuan; Song, Le
2015-01-01
Events in an online social network can be categorized roughly into endogenous events, where users just respond to the actions of their neighbors within the network, or exogenous events, where users take actions due to drives external to the network. How much external drive should be provided to each user, such that the network activity can be steered towards a target state? In this paper, we model social events using multivariate Hawkes processes, which can capture both endogenous and exogenous event intensities, and derive a time dependent linear relation between the intensity of exogenous events and the overall network activity. Exploiting this connection, we develop a convex optimization framework for determining the required level of external drive in order for the network to reach a desired activity level. We experimented with event data gathered from Twitter, and show that our method can steer the activity of the network more accurately than alternatives. PMID:26005312
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Zeev-Wolf, Maor; Goldstein, Abraham; Bonne, Omer; Abramowitz, Eitan G
2016-07-01
Whereas numerous studies have investigated hypnotic analgesia, few have investigated hypnotic anaesthesia. Using magnetoencephalography (MEG) we investigated and localized brain responses (event-related fields and oscillatory activity) during sensory processing under hypnotic anaesthesia. Nineteen right handed neurotypical individuals with moderate-to-high hypnotizability received 100 vibrotactile stimuli to right and left index fingers in a random sequence. Thereafter a hypnotic state was induced, in which anaesthetic suggestion was applied to the left hand only. Once anaesthetic suggestion was achieved, a second, identical, session of vibrotactile stimuli was commenced. We found greater brain activity in response to the stimuli delivered to the left (attenuated) hand before hypnotic anaesthesia, than under hypnotic anaesthesia, in both the beta and alpha bands. In the beta band, the reduction of activity under hypnotic anaesthesia was found around 214-413ms post-stimuli and was located mainly in the right insula. In the alpha band, it was found around 253-500ms post-stimuli and was located mainly in the left inferior frontal gyrus. In a second experiment, attention modulation per se was ruled out as the underlying cause of the effects found. These findings may suggest that the brain mechanism underlying hypnotic anaesthesia involves top-down somatosensory inhibition and, therefore, a reduction of somatosensory awareness. The result of this mechanism is a mental state in which individuals lose bodily sensation. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Synoptic-scale fire weather conditions in Alaska
NASA Astrophysics Data System (ADS)
Hayasaka, Hiroshi; Tanaka, Hiroshi L.; Bieniek, Peter A.
2016-09-01
Recent concurrent widespread fires in Alaska are evaluated to assess their associated synoptic-scale weather conditions. Several periods of high fire activity from 2003 to 2015 were identified using Moderate Resolution Imaging Spectroradiometer (MODIS) hotspot data by considering the number of daily hotspots and their continuity. Fire weather conditions during the top six periods of high fire activity in the fire years of 2004, 2005, 2009, and 2015 were analyzed using upper level (500 hPa) and near surface level (1000 hPa) atmospheric reanalysis data. The top four fire-periods occurred under similar unique high-pressure fire weather conditions related to Rossby wave breaking (RWB). Following the ignition of wildfires, fire weather conditions related to RWB events typically result in two hotspot peaks occurring before and after high-pressure systems move from south to north across Alaska. A ridge in the Gulf of Alaska resulted in southwesterly wind during the first hotspot peak. After the high-pressure system moved north under RWB conditions, the Beaufort Sea High developed and resulted in relatively strong easterly wind in Interior Alaska and a second (largest) hotspot peak during each fire period. Low-pressure-related fire weather conditions occurring under cyclogenesis in the Arctic also resulted in high fire activity under southwesterly wind with a single large hot-spot peak.
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Marcinek, Herbert; Wirth, Reinhard; Muscholl-Silberhorn, Albrecht; Gauer, Matthias
1998-01-01
The ability of Enterococcus faecalis to transfer various genetic elements under natural conditions was tested in two municipal sewage water treatment plants. Experiments in activated sludge basins of the plants were performed in a microcosm which allowed us to work under sterile conditions; experiments in anoxic sludge digestors were performed in dialysis bags. We used the following naturally occurring genetic elements: pAD1 and pIP1017 (two so-called sex pheromone plasmids with restricted host ranges, which are transferred at high rates under laboratory conditions); pIP501 (a resistance plasmid possessing a broad host range for gram-positive bacteria, which is transferred at low rates under laboratory conditions); and Tn916 (a conjugative transposon which is transferred under laboratory conditions at low rates to gram-positive bacteria and at very low rates to gram-negative bacteria). The transfer rate between different strains of E. faecalis under natural conditions was, compared to that under laboratory conditions, at least 105-fold lower for the sex pheromone plasmids, at least 100-fold lower for pIP501, and at least 10-fold lower for Tn916. In no case was transfer from E. faecalis to another bacterial species detected. By determining the dependence of transfer rates for pIP1017 on bacterial concentration and extrapolating to actual concentrations in the sewage water treatment plant, we calculated that the maximum number of transfer events for the sex pheromone plasmids between different strains of E. faecalis in the municipal sewage water treatment plant of the city of Regensburg ranged from 105 to 108 events per 4 h, indicating that gene transfer should take place under natural conditions. PMID:9464401
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Looking inside the microseismic cloud using seismic interferometry
NASA Astrophysics Data System (ADS)
Matzel, E.; Rhode, A.; Morency, C.; Templeton, D. C.; Pyle, M. L.
2015-12-01
Microseismicity provides a direct means of measuring the physical characteristics of active tectonic features such as fault zones. Thousands of microquakes are often associated with an active site. This cloud of microseismicity helps define the tectonically active region. When processed using novel geophysical techniques, we can isolate the energy sensitive to the faulting region, itself. The virtual seismometer method (VSM) is a technique of seismic interferometry that provides precise estimates of the GF between earthquakes. In many ways the converse of ambient noise correlation, it is very sensitive to the source parameters (location, mechanism and magnitude) and to the Earth structure in the source region. In a region with 1000 microseisms, we can calculate roughly 500,000 waveforms sampling the active zone. At the same time, VSM collapses the computation domain down to the size of the cloud of microseismicity, often by 2-3 orders of magnitude. In simple terms VSM involves correlating the waveforms from a pair of events recorded at an individual station and then stacking the results over all stations to obtain the final result. In the far-field, when most of the stations in a network fall along a line between the two events, the result is an estimate of the GF between the two, modified by the source terms. In this geometry each earthquake is effectively a virtual seismometer recording all the others. When applied to microquakes, this alignment is often not met, and we also need to address the effects of the geometry between the two microquakes relative to each seismometer. Nonetheless, the technique is quite robust, and highly sensitive to the microseismic cloud. Using data from the Salton Sea geothermal region, we demonstrate the power of the technique, illustrating our ability to scale the technique from the far-field, where sources are well separated, to the near field where their locations fall within each other's uncertainty ellipse. VSM provides better illumination of the complex subsurface by generating precise, high frequency estimates of the GF and resolution of seismic properties between every pair of events. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344
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Quantifying Information Flow During Emergencies
NASA Astrophysics Data System (ADS)
Gao, Liang; Song, Chaoming; Gao, Ziyou; Barabási, Albert-László; Bagrow, James P.; Wang, Dashun
2014-02-01
Recent advances on human dynamics have focused on the normal patterns of human activities, with the quantitative understanding of human behavior under extreme events remaining a crucial missing chapter. This has a wide array of potential applications, ranging from emergency response and detection to traffic control and management. Previous studies have shown that human communications are both temporally and spatially localized following the onset of emergencies, indicating that social propagation is a primary means to propagate situational awareness. We study real anomalous events using country-wide mobile phone data, finding that information flow during emergencies is dominated by repeated communications. We further demonstrate that the observed communication patterns cannot be explained by inherent reciprocity in social networks, and are universal across different demographics.
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ASSET: Analysis of Sequences of Synchronous Events in Massively Parallel Spike Trains
Canova, Carlos; Denker, Michael; Gerstein, George; Helias, Moritz
2016-01-01
With the ability to observe the activity from large numbers of neurons simultaneously using modern recording technologies, the chance to identify sub-networks involved in coordinated processing increases. Sequences of synchronous spike events (SSEs) constitute one type of such coordinated spiking that propagates activity in a temporally precise manner. The synfire chain was proposed as one potential model for such network processing. Previous work introduced a method for visualization of SSEs in massively parallel spike trains, based on an intersection matrix that contains in each entry the degree of overlap of active neurons in two corresponding time bins. Repeated SSEs are reflected in the matrix as diagonal structures of high overlap values. The method as such, however, leaves the task of identifying these diagonal structures to visual inspection rather than to a quantitative analysis. Here we present ASSET (Analysis of Sequences of Synchronous EvenTs), an improved, fully automated method which determines diagonal structures in the intersection matrix by a robust mathematical procedure. The method consists of a sequence of steps that i) assess which entries in the matrix potentially belong to a diagonal structure, ii) cluster these entries into individual diagonal structures and iii) determine the neurons composing the associated SSEs. We employ parallel point processes generated by stochastic simulations as test data to demonstrate the performance of the method under a wide range of realistic scenarios, including different types of non-stationarity of the spiking activity and different correlation structures. Finally, the ability of the method to discover SSEs is demonstrated on complex data from large network simulations with embedded synfire chains. Thus, ASSET represents an effective and efficient tool to analyze massively parallel spike data for temporal sequences of synchronous activity. PMID:27420734
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Zhou, Shang-Ming; Hill, Rebecca A; Morgan, Kelly; Stratton, Gareth; Gravenor, Mike B; Bijlsma, Gunnar; Brophy, Sinead
2015-01-01
Objective To classify wear and non-wear time of accelerometer data for accurately quantifying physical activity in public health or population level research. Design A bi-moving-window-based approach was used to combine acceleration and skin temperature data to identify wear and non-wear time events in triaxial accelerometer data that monitor physical activity. Setting Local residents in Swansea, Wales, UK. Participants 50 participants aged under 16 years (n=23) and over 17 years (n=27) were recruited in two phases: phase 1: design of the wear/non-wear algorithm (n=20) and phase 2: validation of the algorithm (n=30). Methods Participants wore a triaxial accelerometer (GeneActiv) against the skin surface on the wrist (adults) or ankle (children). Participants kept a diary to record the timings of wear and non-wear and were asked to ensure that events of wear/non-wear last for a minimum of 15 min. Results The overall sensitivity of the proposed method was 0.94 (95% CI 0.90 to 0.98) and specificity 0.91 (95% CI 0.88 to 0.94). It performed equally well for children compared with adults, and females compared with males. Using surface skin temperature data in combination with acceleration data significantly improved the classification of wear/non-wear time when compared with methods that used acceleration data only (p<0.01). Conclusions Using either accelerometer seismic information or temperature information alone is prone to considerable error. Combining both sources of data can give accurate estimates of non-wear periods thus giving better classification of sedentary behaviour. This method can be used in population studies of physical activity in free-living environments. PMID:25968000
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Snow, S J; Cheng, W; Wolberg, A S; Carraway, M S
2014-07-01
Air pollution exposure is associated with cardiovascular events triggered by clot formation. Endothelial activation and initiation of coagulation are pathophysiological mechanisms that could link inhaled air pollutants to vascular events. Here we investigated the underlying mechanisms of increased endothelial cell procoagulant activity following exposure to soluble components of ultrafine particles (soluble UF). Human coronary artery endothelial cells (HCAEC) were exposed to soluble UF and assessed for their ability to trigger procoagulant activity in platelet-free plasma. Exposed HCAEC triggered earlier thrombin generation and faster fibrin clot formation, which was abolished by an anti-tissue factor (TF) antibody, indicating TF-dependent effects. Soluble UF exposure increased TF mRNA expression without compensatory increases in key anticoagulant proteins. To identify early events that regulate TF expression, we measured endothelial H2O2 production following soluble UF exposure and identified the enzymatic source. Soluble UF exposure increased endothelial H2O2 production, and antioxidants attenuated UF-induced upregulation of TF, linking the procoagulant responses to reactive oxygen species (ROS) formation. Chemical inhibitors and RNA silencing showed that NOX-4, an important endothelial source of H2O2, was involved in UF-induced upregulation of TF mRNA. These data indicate that soluble UF exposure induces endothelial cell procoagulant activity, which involves de novo TF synthesis, ROS production, and the NOX-4 enzyme. These findings provide mechanistic insight into the adverse cardiovascular effects associated with air pollution exposure. Published by Oxford University Press on behalf of Toxicological Sciences 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
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Kalyanam, Janani; Quezada, Mauricio; Poblete, Barbara; Lanckriet, Gert
2016-01-01
On-line social networks publish information on a high volume of real-world events almost instantly, becoming a primary source for breaking news. Some of these real-world events can end up having a very strong impact on on-line social networks. The effect of such events can be analyzed from several perspectives, one of them being the intensity and characteristics of the collective activity that it produces in the social platform. We research 5,234 real-world news events encompassing 43 million messages discussed on the Twitter microblogging service for approximately 1 year. We show empirically that exogenous news events naturally create collective patterns of bursty behavior in combination with long periods of inactivity in the network. This type of behavior agrees with other patterns previously observed in other types of natural collective phenomena, as well as in individual human communications. In addition, we propose a methodology to classify news events according to the different levels of intensity in activity that they produce. In particular, we analyze the most highly active events and observe a consistent and strikingly different collective reaction from users when they are exposed to such events. This reaction is independent of an event's reach and scope. We further observe that extremely high-activity events have characteristics that are quite distinguishable at the beginning stages of their outbreak. This allows us to predict with high precision, the top 8% of events that will have the most impact in the social network by just using the first 5% of the information of an event's lifetime evolution. This strongly implies that high-activity events are naturally prioritized collectively by the social network, engaging users early on, way before they are brought to the mainstream audience.
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Development of an ATR Workbench for SAR Imagery
2002-12-01
containing a representation of the object. Each image representation contains only a subset of information about t, and that information is often...GUI. In the case of HNeT under Windows, the native COM/ ActiveX automation interface is used. This provides Python with direct access to the many...that can contain other objects such as a menu bar, buttons, an image display area, text box etc. The library also provides an event handling mechanism
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Signals of New Physics in the Underlying Event
DOE Office of Scientific and Technical Information (OSTI.GOV)
Harnik, Roni; /Stanford U., ITP /SLAC; Wizansky, Tommer
2010-06-11
LHC searches for new physics focus on combinations of hard physics objects. In this work we propose a qualitatively different soft signal for new physics at the LHC - the 'anomalous underlying event'. Every hard LHC event will be accompanied by a soft underlying event due to QCD and pile-up effects. Though it is often used for QCD and monte carlo studies, here we propose the incorporation of an underlying event analysis in some searches for new physics. An excess of anomalous underlying events may be a smoking-gun signal for particular new physics scenarios such as 'quirks' or 'hidden valleys'more » in which large amounts of energy may be emitted by a large multiplicity of soft particles. We discuss possible search strategies for such soft diffuse signals in the tracking system and calorimetry of the LHC experiments. We present a detailed study of the calorimetric signal in a concrete example, a simple quirk model motivated by folded supersymmetry. In these models the production and radiative decay of highly excited quirk bound states leads to an 'antenna pattern' of soft unclustered energy. Using a dedicated simulation of a toy detector and a 'CMB-like' multipole analysis we compare the signal to the expected backgrounds.« less
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NASA Astrophysics Data System (ADS)
Heyerdahl, Håkon; Høydal, Øyvind
2016-04-01
The Gudbrandsdalen valley in Eastern Norway lies in a region where annual precipitation is generally low (down to 300 mm/year). The landslide activity has consequently historically been low, although the lower part of the valley sides generally is draped with thick layers of Quaternary deposits, primarily of glacial or glaciofluvial origin. The perception of natural hazards in the valley was previously primarily connected to flooding in the main river in the valley bottom during early summer, due to large discharges resulting from snowmelt in the mountainous regions west and east of the valley. However, several high-intensity events have changed the image of the region. Starting with a localized, but intense, landslide event in the Northern part of the valley in year 2008, two larger events covering almost the entire valley occurred in the years 2011 and 2013. A high number of landslides was triggered in all these events, including many flash floods and debris flows/debris slides in small and steep tributary rivers along the valley slopes. Landslide triggering covers different release mechanisms: In 2008, landslides were triggered without precipitation in not-frozen soil deposits without snow cover in the lower part of the valley. Groundwater flow through the permeable bedrock ("Otta schist") resulting from snow-melt in the elevated mountainous areas caused landslide triggering due to positive pore-water pressures forming at the bedrock surface below soil deposits, or at depressions in the terrain. Subsequent rainfall resulted in even more landslides being released. In later events (years 2011 and 2013) many landslides were caused by surface water taking new paths downslope, often due to man-made changes in existing waterways (typically poorly planned drainage solutions or new roads). Relatively small discharges in slopes with unconsolidated and easily erodible glacial deposits (typically lateral moraine) in many cases lead to small initial slides that down-slope developed into large erosional debris slides/floods of considerable size. Also along existing tributary rivers, the intense rainfall events resulted in flash-floods with heavy erosion and entrainment of deposits from the riverbed, including massive transport of trees. Also on open slopes a number of landslides were observed, assumedly triggered primarily by direct infiltration of rainfall, and possibly assisted by groundwater flow in underlying bedrock. Considerable damage to infrastructure and also dwellings has resulted from the events. A new approach has proved necessary to capture the risk elements connect to landslide and flood for this valley region when it comes to planning purposes. Among others, there is a need to consider the potential damage resulting from under-dimensioned culverts leading to complete failure of railroad or road embankments). Work is underway in order to improve the understanding of release mechanisms for typical landslides in the valley, which also will be highly relevant for other areas in Norway were similar natural hazards are encountered, and where climatic change may change the regional landslide activity.
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Amplification of seismic waves beneath active volcanoes
NASA Astrophysics Data System (ADS)
Navon, O.; Lensky, N. G.; Collier, L.; Neuberg, J.; Lyakhovsky, V.
2003-04-01
Long-period (LP) seismic events are typical of many volcanoes and are attributed to energy leaking from waves traveling through the volcanic conduit or along the conduit - country-rock interface. The LP events are triggered locally, at the volcanic edifice, but the source of energy for the formation of tens of events per day is not clear. Energy may be supplied by volatile-release from a supersaturated melt. If bubbles are present in equilibrium with the melt in the conduit, and the melt is suddenly decompressed, transfer of volatiles from the supersaturated melt into the bubbles transforms stored potential energy into expansion work. For example, small dome collapses may decompress the conduit by a few bars and lead to solubility decrease, exsolution of volatiles and, consequently, to work done by the expansion of the bubbles under pressure. This energy is released over a timescale that is similar to that of LP events and may amplify the original weak seismic signals associated with the collapse. Using the formulation of Lensky et al. (2002), following the decompression, when the transfer of volatiles into bubbles is fast enough, expansion accelerates and the bulk viscosity of the bubbly magma is negative. New calculations show that under such conditions a sinusoidal P-wave is amplified. We note that seismic waves created by tectonic earthquakes that are not associated with net decompression, do not lead to net release of volatiles or to net expansion. In this case, the bulk viscosity is positive and waves traveling through the magma should attenuate. The proposed model explains how weak seismic signals may be amplified as they travel through a conduit that contains supersaturated bubbly magma. It provides the general framework for amplifying volcanic seismicity such as the signals associated with long-period events.
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Babić, Zdravko; Pavlov, Marin; Oštrić, Mirjana; Milošević, Milan; Misigoj Duraković, Marjeta; Pintarić, Hrvoje
2015-01-01
To investigate the aspects of return to work, socio-economic and quality of life aspects in 145 employed patients under 60 years of age treated with primary percutaneous coronary intervention for acute ST-elevation myocardial infarction. During hospital treatment demographic and clinical data was collected. Data about major adverse cardiovascular events, rehabilitation, sick leave, discharge from job and retirement, salary, major life events and estimation of quality of life after myocardial infarction were obtained after follow-up (mean: 836±242 days). Average sick leave was 126±125 days. Following myocardial infarction, 3.4% of patients were discharged from their jobs while 31.7% retired. Lower salary was reported in 17.9% patients, major life events in 9.7%, while 40.7% estimated quality of life as worse following the event. Longer hospitalization was reported in patients transferred from surrounding counties, those with inferior myocardial wall and right coronary artery affected. Age, hyperlipoproteinemia and lower education degree were connected to permanent working cessation. Significant salary decrease was observed in male patients. Employer type was related to sick leave duration. Impaired quality of life was observed in patients who underwent in-hospital rehabilitation and those from surrounding counties. Longer sick leave was observed in patients with lower income before and after myocardial infarction. These patients reported lower quality of life after myocardial infarction. Inadequate health policy and delayed cardiac rehabilitation after myocardial infarction may lead to prolonged hospitalization and sick leave as well as lower quality of life after the event, regardless of optimal treatment in acute phase of disease. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
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Al Abed, Alice Shaam; Sellami, Azza; Brayda-Bruno, Laurent; Lamothe, Valérie; Noguès, Xavier; Potier, Mylène; Bennetau-Pelissero, Catherine; Marighetto, Aline
2016-07-01
Because estrogens have mostly been studied in gonadectomized females, effects of chronic exposure to environmental estrogens in the general population are underestimated. Estrogens can enhance hippocampus-dependent memory through the modulation of information storage. However, declarative memory, the hippocampus-dependent memory of facts and events, demands more than abilities to retain information. Specifically, memory of repetitive events of everyday life such as "where I parked" requires abilities to organize/update memories to prevent proactive interference from similar memories of previous "parking events". Whether such organizational processes are estrogen-sensitive is unknown. We here studied, in intact young and aged adult mice, drinking-water (1μM) estradiol effects on both retention and organizational components of hippocampus-dependent memory, using a radial-maze task of everyday-like memory. Demand on retention vs organization was manipulated by varying the time-interval separating repetitions of similar events. Estradiol increased performance in young and aged mice under minimized organizational demand, but failed to improve the age-associated memory impairment and diminished performance in young mice under high organizational demand. In fact, estradiol prolonged mnemonic retention of successive events without improving organization abilities, hence resulted in more proactive interference from irrelevant memories. c-Fos imaging of testing-induced brain activations showed that the deterioration of young memory was associated with dentate gyrus dysconnectivity, reminiscent of that seen in aged mice. Our findings support the view that estradiol is promnesic but also reveal that such property can paradoxically impair memory. These findings have important outcomes regarding health issues relative to the impact of environmental estrogens in the general population. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Deng, Lei; Jiao, Peng; Pei, Jing; Wu, Zhenzhi; Li, Guoqi
2018-04-01
Although deep neural networks (DNNs) are being a revolutionary power to open up the AI era, the notoriously huge hardware overhead has challenged their applications. Recently, several binary and ternary networks, in which the costly multiply-accumulate operations can be replaced by accumulations or even binary logic operations, make the on-chip training of DNNs quite promising. Therefore there is a pressing need to build an architecture that could subsume these networks under a unified framework that achieves both higher performance and less overhead. To this end, two fundamental issues are yet to be addressed. The first one is how to implement the back propagation when neuronal activations are discrete. The second one is how to remove the full-precision hidden weights in the training phase to break the bottlenecks of memory/computation consumption. To address the first issue, we present a multi-step neuronal activation discretization method and a derivative approximation technique that enable the implementing the back propagation algorithm on discrete DNNs. While for the second issue, we propose a discrete state transition (DST) methodology to constrain the weights in a discrete space without saving the hidden weights. Through this way, we build a unified framework that subsumes the binary or ternary networks as its special cases, and under which a heuristic algorithm is provided at the website https://github.com/AcrossV/Gated-XNOR. More particularly, we find that when both the weights and activations become ternary values, the DNNs can be reduced to sparse binary networks, termed as gated XNOR networks (GXNOR-Nets) since only the event of non-zero weight and non-zero activation enables the control gate to start the XNOR logic operations in the original binary networks. This promises the event-driven hardware design for efficient mobile intelligence. We achieve advanced performance compared with state-of-the-art algorithms. Furthermore, the computational sparsity and the number of states in the discrete space can be flexibly modified to make it suitable for various hardware platforms. Copyright © 2018 Elsevier Ltd. All rights reserved.
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SCAR/WAVE and Arp2/3 are critical for cytoskeletal remodeling at the site of myoblast fusion
Richardson, Brian E.; Beckett, Karen; Nowak, Scott J.; Baylies, Mary K.
2010-01-01
Summary Myoblast fusion is critical for formation and repair of skeletal muscle. Here we show that active remodeling of the actin cytoskeleton is essential for fusion in Drosophila. Using live imaging, we have identified a dynamic F-actin accumulation (actin focus) at the site of fusion. Dissolution of the actin focus directly precedes a fusion event. Whereas several known fusion components regulate these actin foci, others target additional behaviors required for fusion. Mutations in kette/Nap1, an actin polymerization regulator, lead to enlarged foci that do not dissolve, consistent with the observed block in fusion. Kette is required to positively regulate SCAR/WAVE, which in turn activates the Arp2/3 complex. Mutants in SCAR and Arp2/3 have a fusion block and foci phenotype, suggesting that Kette-SCAR-Arp2/3 participate in an actin polymerization event required for focus dissolution. Our data identify a new paradigm for understanding the mechanisms underlying fusion in myoblasts and other tissues. PMID:18003739
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Astronomy Education Under Dark Skies
NASA Astrophysics Data System (ADS)
Cecylia Molenda-Zakowicz, Joanna
2015-08-01
We have been providing professional support for the high school students and the astronomy teachers since 2007. Our efforts include organizing astronomy events that take from several hours, like, e.g., watching the transit of Venus, to several days, like the workshops organized in the framework of the projects 'School Workshops on Astronomy' (SWA) and 'Wygasz'.The SWA and Wygasz workshops include presentations by experts in astronomy and space science research, presentations prepared by students being supervised by those experts, hands-on interactive experience in the amateur astrophotography, various pencil-and-paper exercises, and other practical activities. We pay particular attention to familiarize the teachers and students with the idea and the necessity of protecting the dark sky. The format of these events allows also for some time for teachers to share ideas and best practices in teaching astronomy.All those activities are organized either in the Izera Dark-Sky Park in Poland or in other carefuly selected locations in which the beauty of the dark night sky can be appreciated.
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Narrative writing: Effective ways and best practices
Ledade, Samir D.; Jain, Shishir N.; Darji, Ankit A.; Gupta, Vinodkumar H.
2017-01-01
A narrative is a brief summary of specific events experienced by patients, during the course of a clinical trial. Narrative writing involves multiple activities such as generation of patient profiles, review of data sources, and identification of events for which narratives are required. A sponsor outsources narrative writing activities to leverage the expertise of service providers which in turn requires effective management of resources, cost, time, quality, and overall project management. Narratives are included as an appendix to the clinical study report and are submitted to the regulatory authorities as a part of dossier. Narratives aid in the evaluation of the safety profile of the investigational drug under study. To deliver high-quality narratives within the specified timeframe to the sponsor can be achieved by standardizing processes, increasing efficiency, optimizing working capacity, implementing automation, and reducing cost. This paper focuses on effective ways to design narrative writing process and suggested best practices, which enable timely delivery of high-quality narratives to fulfill the regulatory requirement. PMID:28447014
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A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching
La Torre, A; del Mar Masdeu, M; Cotrufo, T; Moubarak, R S; del Río, J A; Comella, J X; Soriano, E; Ureña, J M
2013-01-01
Neurotrophins are involved in many crucial cellular functions, including neurite outgrowth, synapse formation, and plasticity. Although these events have long been known, the molecular determinants underlying neuritogenesis have not been fully characterized. Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is highly expressed in the brain. Here, we demonstrate that Ack1 is a molecular constituent of neurotrophin signaling cascades in neurons and PC12 cells. We report that Ack1 interacts with Trk receptors and becomes tyrosine phosphorylated and its kinase activity is increased in response to neurotrophins. Moreover, our data indicate that Ack1 acts upstream of the Akt and MAPK pathways. We show that Ack1 overexpression induces neuritic outgrowth and promotes branching in neurotrophin-treated neuronal cells, whereas the expression of Ack1 dominant negatives or short-hairpin RNAs counteract neurotrophin-stimulated differentiation. Our results identify Ack1 as a novel regulator of neurotrophin-mediated events in primary neurons and in PC12 cells. PMID:23598414
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Dopamine Receptor Activation Reorganizes Neuronal Ensembles during Hippocampal Sharp Waves In Vitro
Miyawaki, Takeyuki; Norimoto, Hiroaki; Ishikawa, Tomoe; Watanabe, Yusuke; Matsuki, Norio; Ikegaya, Yuji
2014-01-01
Hippocampal sharp wave (SW)/ripple complexes are thought to contribute to memory consolidation. Previous studies suggest that behavioral rewards facilitate SW occurrence in vivo. However, little is known about the precise mechanism underlying this enhancement. Here, we examined the effect of dopaminergic neuromodulation on spontaneously occurring SWs in acute hippocampal slices. Local field potentials were recorded from the CA1 region. A brief (1 min) treatment with dopamine led to a persistent increase in the event frequency and the magnitude of SWs. This effect lasted at least for our recording period of 45 min and did not occur in the presence of a dopamine D1/D5 receptor antagonist. Functional multineuron calcium imaging revealed that dopamine-induced SW augmentation was associated with an enriched repertoire of the firing patterns in SW events, whereas the overall tendency of individual neurons to participate in SWs and the mean number of cells participating in a single SW were maintained. Therefore, dopaminergic activation is likely to reorganize cell assemblies during SWs. PMID:25089705
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Narrative writing: Effective ways and best practices.
Ledade, Samir D; Jain, Shishir N; Darji, Ankit A; Gupta, Vinodkumar H
2017-01-01
A narrative is a brief summary of specific events experienced by patients, during the course of a clinical trial. Narrative writing involves multiple activities such as generation of patient profiles, review of data sources, and identification of events for which narratives are required. A sponsor outsources narrative writing activities to leverage the expertise of service providers which in turn requires effective management of resources, cost, time, quality, and overall project management. Narratives are included as an appendix to the clinical study report and are submitted to the regulatory authorities as a part of dossier. Narratives aid in the evaluation of the safety profile of the investigational drug under study. To deliver high-quality narratives within the specified timeframe to the sponsor can be achieved by standardizing processes, increasing efficiency, optimizing working capacity, implementing automation, and reducing cost. This paper focuses on effective ways to design narrative writing process and suggested best practices, which enable timely delivery of high-quality narratives to fulfill the regulatory requirement.
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NASA Astrophysics Data System (ADS)
Messina, A. T.; Biggs, T. W.
2014-12-01
Anthropogenic watershed disturbance by agriculture, deforestation, roads, and urbanization can alter the timing, composition, and mass of sediment loads to adjacent coral reefs, causing enhanced sediment stress on corals near the outlets of impacted watersheds like Faga'alu, American Samoa. To quantify the increase in sediment loading to the adjacent priority coral reef experiencing sedimentation stress, suspended-sediment yield (SSY) from undisturbed and human-disturbed portions of a small, steep, tropical watershed was measured during baseflow and storm events of varying magnitude. Data on precipitation, discharge, turbidity, and suspended-sediment concentration (SSC) were collected over three field campaigns and continuous monitoring from January 2012 to March 2014, which included 88 storm events. A combination of paired- and nested-watershed study designs using sediment budget, disturbance ratio, and sediment rating curve methodologies was used to quantify the contribution of human-disturbed areas to total SSY. SSC during base- and stormflows was significantly higher downstream of an open-pit aggregate quarry, indicating the quarry is a key sediment source requiring sediment discharge mitigation. Comparison of event-wise SSY from the upper, undisturbed watershed, and the lower, human-disturbed watershed showed the Lower watershed accounted for more than 80% of total SSY on average, and human activities have increased total sediment loading to the coast by approximately 200%. Four storm characteristics were tested as predictors of event SSY using Pearson's and Spearman's correlation coefficients. Similar to mountainous watersheds in semi-arid and temperate watersheds, SSY from both the undisturbed and disturbed watersheds had the highest correlation with event maximum discharge, Qmax (Pearson's R=0.88 and 0.86 respectively), and were best fit by a power law relationship. The resulting model of event-SSY from Faga'alu is being incorporated as part of a larger project investigating relationships and interactions between terrigenous sediment, water circulation over the reef, and the spatial distribution of sediment accumulation under various conditions in a linked watershed and fringing-reef embayment.
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Bringing the Universe to the Valley of the Sun: Astronomy Outreach at Arizona State University
NASA Astrophysics Data System (ADS)
Ashcraft, Teresa; Knierman, K. A.; Taylor, W. L.; Rutkowski, M. J.
2012-01-01
The focal point of astronomy outreach at ASU is Astronomy Open House, which has run for more than 3 decades. It is a free event for the local community and provides an opportunity for night sky viewings with telescopes, interactions with scientist, and discussion of contemporary topics. Typically each Open House will also offer a planetarium show, activities for kids, and displays on meteorites, the Moon, and geology. During the 2010-2011 academic year approximately 900 people attended the 6 Open Houses. This was a record attendance and was in part due to targeted advertisement to K-12 student groups. To accommodate this growth we recruited additional undergraduate student volunteers, including those from both science and non-science academic backgrounds. We present here a summary of traditional Open House activities and new partnerships developed as a result of the increased volunteer pool. Through Open House we were able to partner with other programs at ASU and in the Phoenix area and the expanded community presence developed into new events at local schools and museums (e.g., Arizona Science Center, Phoenix Zoo). Additionally, in conjunction with the International Year of Astronomy, we hosted two events for local, traditionally under-served students in which the students learned about Galileo and built their own Galileoscopes for free. In June 2011, we visited the Tsaile Public School on the Navajo Reservation to present a series of hands-on astronomy activities including a guided program inside a portable STARLAB planetarium to over 60 Navajo students. T. Ashcraft is supported by an Arizona NASA Space Grant Fellowship. Open House is partially supported by ASU USG. Funding for Galileoscopes provided by ASU GPSA. NASA Summer of Innovation program supports events in Tsaile, AZ.
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The Age of Terrestrial Carbon Export and Rainfall Intensity in a Temperate River Headwater System
NASA Astrophysics Data System (ADS)
Tittel, J.; Büttner, O.; Freier, K.; Heiser, A.; Sudbrack, R.; Ollesch, G.
2013-12-01
Riverine dissolved organic carbon (DOC) supports the production of estuaries and coastal ecosystems, constituting one of the most actively recycled pools of the global carbon cycle. A substantial proportion of DOC entering oceans is highly aged, but its origins remain unclear. Significant fluxes of old DOC have never been observed in temperate headwaters where terrestrial imports take place. Here, we studied the radiocarbon age of DOC in three streams draining forested headwater catchments of the river Mulde (Ore Mountains, Germany). We found modern DOC at moderately dry and moderately wet conditions as well as at high discharges during snowmelt. Old groundwater carbon contributed to stream DOC during the summer drought, although the yield was negligible. However, in a four-week summer precipitation event DOC aged at between 160 and 270 years was delivered into the watershed. In one stream, the DOC was modern but depleted in radiocarbon compared to other hydrological conditions. The yield was substantial and corresponded to 20 to 52% of the annual DOC yields in wet and dry years, respectively. Time-integrating samples of a downstream reservoir also revealed modern DOC ages under moderate conditions and old DOC from the rainfall event. Earlier studies suggested that increasing precipitation escalates the contribution of modern DOC from topsoil layers to surface runoff. Our results demonstrate a step change occurring if rainfall intensities increase and become extreme; then the consequences lead to the mobilization of old carbon in exceptionally high concentrations. The runoff/precipitation ratios of rainfall events indicated that during extreme events upland areas of the catchments were hydrologically connected to the stream and upland DOC was activated. Furthermore, the analysis of long-term data suggested that the DOC export in extreme precipitation events added to the annual yield and was not compensated for by lower exports in remaining periods. We conclude that climate change, along with additional processes associated with human activities, channels old soil carbon into more rapidly cycled carbon pools of the hydrosphere.
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NASA Astrophysics Data System (ADS)
Sgattoni, Giulia; Jeddi, Zeinab; Gudmundsson, Ólafur; Einarsson, Páll; Tryggvason, Ari; Lund, Björn; Lucchi, Federico
2016-09-01
Katla is a threatening volcano in Iceland, partly covered by the Mýrdalsjökull ice cap. The volcano has a large caldera with several active geothermal areas. A peculiar cluster of long-period seismic events started on Katla's south flank in July 2011, during an unrest episode in the caldera that culminated in a glacier outburst. The seismic events were tightly clustered at shallow depth in the Gvendarfell area, 4 km south of the caldera, under a small glacier stream at the southern margin of Mýrdalsjökull. No seismic events were known to have occurred in this area before. The most striking feature of this seismic cluster is its temporal pattern, characterized by regular intervals between repeating seismic events, modulated by a seasonal variation. Remarkable is also the stability of both the time and waveform features over a long time period, around 3.5 years. We have not found any comparable examples in the literature. Both volcanic and glacial processes can produce similar waveforms and therefore have to be considered as potential seismic sources. Discerning between these two causes is critical for monitoring glacier-clad volcanoes and has been controversial at Katla. For this new seismic cluster on the south flank, we regard volcano-related processes as more likely than glacial ones for the following reasons: 1) the seismic activity started during an unrest episode involving sudden melting of the glacier and a jökulhlaup; 2) the glacier stream is small and stagnant; 3) the seismicity remains regular and stable for years; 4) there is no apparent correlation with short-term weather changes, such as rainstorms. We suggest that a small, shallow hydrothermal system was activated on Katla's south flank in 2011, either by a minor magmatic injection or by changes of permeability in a local crack system.
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Decoding fMRI Signatures of Real-world Autobiographical Memory Retrieval.
Rissman, Jesse; Chow, Tiffany E; Reggente, Nicco; Wagner, Anthony D
2016-04-01
Extant neuroimaging data implicate frontoparietal and medial-temporal lobe regions in episodic retrieval, and the specific pattern of activity within and across these regions is diagnostic of an individual's subjective mnemonic experience. For example, in laboratory-based paradigms, memories for recently encoded faces can be accurately decoded from single-trial fMRI patterns [Uncapher, M. R., Boyd-Meredith, J. T., Chow, T. E., Rissman, J., & Wagner, A. D. Goal-directed modulation of neural memory patterns: Implications for fMRI-based memory detection. Journal of Neuroscience, 35, 8531-8545, 2015; Rissman, J., Greely, H. T., & Wagner, A. D. Detecting individual memories through the neural decoding of memory states and past experience. Proceedings of the National Academy of Sciences, U.S.A., 107, 9849-9854, 2010]. Here, we investigated the neural patterns underlying memory for real-world autobiographical events, probed at 1- to 3-week retention intervals as well as whether distinct patterns are associated with different subjective memory states. For 3 weeks, participants (n = 16) wore digital cameras that captured photographs of their daily activities. One week later, they were scanned while making memory judgments about sequences of photos depicting events from their own lives or events captured by the cameras of others. Whole-brain multivoxel pattern analysis achieved near-perfect accuracy at distinguishing correctly recognized events from correctly rejected novel events, and decoding performance did not significantly vary with retention interval. Multivoxel pattern classifiers also differentiated recollection from familiarity and reliably decoded the subjective strength of recollection, of familiarity, or of novelty. Classification-based brain maps revealed dissociable neural signatures of these mnemonic states, with activity patterns in hippocampus, medial PFC, and ventral parietal cortex being particularly diagnostic of recollection. Finally, a classifier trained on previously acquired laboratory-based memory data achieved reliable decoding of autobiographical memory states. We discuss the implications for neuroscientific accounts of episodic retrieval and comment on the potential forensic use of fMRI for probing experiential knowledge.
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Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors
Chu, Brian; Liu, Che-Hsiung; Sengupta, Sukanya; Gupta, Amit; Raghu, Padinjat
2013-01-01
Absolute visual thresholds are limited by “dark noise,” which in Drosophila photoreceptors is dominated by brief (∼10 ms), small (∼2 pA) inward current events, occurring at ∼2/s, believed to reflect spontaneous G protein activations. These dark events were increased in rate and amplitude by a point mutation in myosin III (NINAC), which disrupts its interaction with the scaffolding protein, INAD. This phenotype mimics that previously described in null mutants of ninaC (no inactivation no afterpotential; encoding myosin III) and an associated protein, retinophilin (rtp). Dark noise was similarly increased in heterozygote mutants of diacylglycerol kinase (rdgA/+). Dark noise in ninaC, rtp, and rdgA/+ mutants was greatly suppressed by mutations of the Gq α-subunit (Gαq) and the major light-sensitive channel (trp) but not rhodopsin. ninaC, rtp, and rdgA/+ mutations also all facilitated residual light responses in Gαq and PLC hypomorphs. Raising cytosolic Ca2+ in the submicromolar range increased dark noise, facilitated activation of transient receptor potential (TRP) channels by exogenous agonist, and again facilitated light responses in Gαq hypomorphs. Our results indicate that RTP, NINAC, INAD, and diacylglycerol kinase, together with a Ca2+-dependent threshold, share common roles in suppressing dark noise and regulating quantum bump generation; consequently, most spontaneous G protein activations fail to generate dark events under normal conditions. By contrast, quantum bump generation is reliable but delayed until sufficient G proteins and PLC are activated to overcome threshold, thereby ensuring generation of full-size bumps with high quantum efficiency. PMID:23365183
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Event Segmentation Improves Event Memory up to One Month Later
ERIC Educational Resources Information Center
Flores, Shaney; Bailey, Heather R.; Eisenberg, Michelle L.; Zacks, Jeffrey M.
2017-01-01
When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the events. If segmenting events effectively leads to better memory, does asking people to attend to segmentation improve subsequent memory? To answer…
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NASA Technical Reports Server (NTRS)
Lupton, W. F.; Conrad, A. R.
1992-01-01
KTL is a set of routines which eases the job of writing applications which must interact with a variety of underlying sub-systems (known as services). A typical application is an X Window user interface coordinating telescope and instruments. In order to connect to a service, application code specifies a service name--typically an instrument name--and a style, which defines the way in which the application will interact with the service. Two styles are currently supported: keyword, where the application reads and writes named keywords and the resulting inter-task message traffic is hidden; and message, where the application deals directly with messages. The keyword style is intended mainly for user interfaces, and the message style is intended mainly for lower-level applications. KTL applications are event driven: a typical application first connects to all its desired services, then expresses interest in specified events. The application then enters an event dispatch loop in which it waits for events and calls the appropriate service's event-handling routine. Each event is associated with a call-back routine which is invoked when the event occurs. Call-back routines may (and typically do) interact with other sub-systems and KTL provides the means of doing so without blocking the application (vital for X Window user interfaces). This approach is a marriage of ideas culled from the X window, ADAM, Keck instrument, and Keck telescope control systems. A novel feature of KTL is that it knows nothing about any services or styles. Instead it defines a generic set of routines which must be implemented by all services and styles (essentially open(), ioctl(), read(), write(), event(), and close()) and activates sharable libraries at run-time. Services have been implemented (in both keyword and message styles) for HIRES (the Keck high resolution echelle spectrograph built by Lick Observatory), LWS (the Keck long wavelength spectrometer built by UC San Diego), and the Keck telescope. Each of these implementations uses different underlying message systems: the Lick MUSIC system, RPC's, and direct sockets (respectively). Services for the remaining three front-line Keck instruments will be implemented over the next few months.
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Where the imaginal appears real: A positron emission tomography study of auditory hallucinations
Szechtman, Henry; Woody, Erik; Bowers, Kenneth S.; Nahmias, Claude
1998-01-01
An auditory hallucination shares with imaginal hearing the property of being self-generated and with real hearing the experience of the stimulus being an external one. To investigate where in the brain an auditory event is “tagged” as originating from the external world, we used positron emission tomography to identify neural sites activated by both real hearing and hallucinations but not by imaginal hearing. Regional cerebral blood flow was measured during hearing, imagining, and hallucinating in eight healthy, highly hypnotizable male subjects prescreened for their ability to hallucinate under hypnosis (hallucinators). Control subjects were six highly hypnotizable male volunteers who lacked the ability to hallucinate under hypnosis (nonhallucinators). A region in the right anterior cingulate (Brodmann area 32) was activated in the group of hallucinators when they heard an auditory stimulus and when they hallucinated hearing it but not when they merely imagined hearing it. The same experimental conditions did not yield this activation in the group of nonhallucinators. Inappropriate activation of the right anterior cingulate may lead self-generated thoughts to be experienced as external, producing spontaneous auditory hallucinations. PMID:9465124
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Sources of seismic events in the cooling lava lake of Kilauea Iki, Hawaii
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chouet, B.
1979-05-10
Seismic surveys conducted in recent years revealed a suprisingly high and sustained activity of local seismic events originating in the partially frozen lava lake of Kilauea Iki crater, Hawaii. About 8000 events per day were counted in 1976 at the center of the lake with a seismograph having a peak magnification of 280,000 at 60 Hz. The activity was found to be uniform over the whole area above the inferred magma lens and very weak in the periphery of the lake. The frequency-amplitude relation for these shocks obeys the Ishimoto-Iida or Gutenberg-Richter law very well, with a b value ofmore » 1.19( +- 0.06). Locations of a few selected events indicate that they occur both above and below the layer of melt, although the seismic activity appears to be much higher in the upper crust. Whenever clear, the first motion is always outward from the source, suggesting that a crack opening under tensile stress owing to cooling is the responsible source mechanism. A simple model of a circular tensile crack nucleating at a point and growing at subsonic velocity can match the far-field P wave from these sources fairly well. Typical parameters for a large event inferred from the model are the following: radius, 2.7 m; maximum static tensile displacement between crack faces, 2.9..mu..; cavity volume, 4.4 x 10/sup -5/ m/sup 3/; and a seismic moment tensor with diagonal elements only, having the values 3.8 x 10/sup 2/exclamation2, 4.5 x 10/sup 12/, and 3.8 x 10/sup 12/ dyn cm. The magnitude of the event is about -1, and its stress drop is of the order of 0.01 bar. A Q as low as 10 is required to satisfy the shape of the observed wave forms. The total cavity volume integrated over all cracks which is generated daily in the upper crust of Kilauea Iki is of the order of 1--20 m/sup 3/. An alternate interpretation of the data, the seismic activity as reflecting the extension by up to several tens of centimeters of long existing cracks rather than the formation of new cracks.« less
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Changes in Cortical Activity During Real and Imagined Movements: an ERP Study
Machado, Sergio; Arias-Carrión, Oscar; Paes, Flávia; Ribeiro, Pedro; Cagy, Mauricio; Piedade, Roberto; Almada, Leonardo Ferreira; Anghinah, Renato; Basile, Luis; Moro, Maria Francesca; Orsini, Marco; Silva, Julio Guilherme; Silva, Adriana Cardoso; Nardi, Antonio E.
2013-01-01
This study aims to compare the topographic distribution of cortical activation between real and imagined movement through event-related potential (ERP). We are specifically interested in identifying, the topographic distribution of activated areas, the intensity of activated areas, and the temporal occurrence of these activations on preparation and motor response phases. Twelve healthy and right handed subjects were instructed to perform a task under real and imagery conditions. The task was performed simultaneously to electroencephalographic (EEG) recording. When compared the conditions, we found a statistically significant difference in favor of real condition revealed by performing an unpaired t-test with multiple corrections of Bonferroni, demonstrating negative activity on electrode C3 and positive activity on the electrode C4 only in motor response phase. These findings revealed similar functional connections established during real and imagery conditions, suggesting that there are common neural substrate and similar properties of functional integration shared by conditions. PMID:24358049
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Changes in Cortical Activity During Real and Imagined Movements: an ERP Study.
Machado, Sergio; Arias-Carrión, Oscar; Paes, Flávia; Ribeiro, Pedro; Cagy, Mauricio; Piedade, Roberto; Almada, Leonardo Ferreira; Anghinah, Renato; Basile, Luis; Moro, Maria Francesca; Orsini, Marco; Silva, Julio Guilherme; Silva, Adriana Cardoso; Nardi, Antonio E
2013-11-15
This study aims to compare the topographic distribution of cortical activation between real and imagined movement through event-related potential (ERP). We are specifically interested in identifying, the topographic distribution of activated areas, the intensity of activated areas, and the temporal occurrence of these activations on preparation and motor response phases. Twelve healthy and right handed subjects were instructed to perform a task under real and imagery conditions. The task was performed simultaneously to electroencephalographic (EEG) recording. When compared the conditions, we found a statistically significant difference in favor of real condition revealed by performing an unpaired t-test with multiple corrections of Bonferroni, demonstrating negative activity on electrode C3 and positive activity on the electrode C4 only in motor response phase. These findings revealed similar functional connections established during real and imagery conditions, suggesting that there are common neural substrate and similar properties of functional integration shared by conditions.
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Brain Activity and Human Unilateral Chewing
Quintero, A.; Ichesco, E.; Myers, C.; Schutt, R.; Gerstner, G.E.
2012-01-01
Brain mechanisms underlying mastication have been studied in non-human mammals but less so in humans. We used functional magnetic resonance imaging (fMRI) to evaluate brain activity in humans during gum chewing. Chewing was associated with activations in the cerebellum, motor cortex and caudate, cingulate, and brainstem. We also divided the 25-second chew-blocks into 5 segments of equal 5-second durations and evaluated activations within and between each of the 5 segments. This analysis revealed activation clusters unique to the initial segment, which may indicate brain regions involved with initiating chewing. Several clusters were uniquely activated during the last segment as well, which may represent brain regions involved with anticipatory or motor events associated with the end of the chew-block. In conclusion, this study provided evidence for specific brain areas associated with chewing in humans and demonstrated that brain activation patterns may dynamically change over the course of chewing sequences. PMID:23103631
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Dissecting the active site of a photoreceptor protein
NASA Astrophysics Data System (ADS)
Hoff, Wouter; Hara, Miwa; Ren, Jie; Moghadam, Farzaneh; Xie, Aihua; Kumauchi, Masato
While enzymes are quite large molecules, functionally important chemical events are often limited to a small region of the protein: the active site. The physical and chemical properties of residues at such active sites are often strongly altered compared to the same groups dissolved in water. Understanding such effects is important for unraveling the mechanisms underlying protein function and for protein engineering, but has proven challenging. Here we report on our ongoing efforts on using photoactive yellow protein (PYP), a bacterial photoreceptor, as a model system for such effects. We will report on the following questions: How many residues affect active site properties? Are these residues in direct physical contact with the active site? Can functionally important residues be recognized in the crystal structure of a protein? What structural resolution is needed to understand active sites? What spectroscopic techniques are most informative? Which weak interactions dominate active site properties?
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Liu, Justina Yat-Wa; Ma, Ka Wai
2017-01-31
The Reintegration to Normal Living Index (RNLI) was developed to measure reintegration to normal living after major traumas/illnesses. Its psychometric properties remain unknown when used to measure participation restriction under the World Health Organization's International Classification of Functioning, Disability, and Health (WHO-ICF) framework. This study examines the psychometric properties of the Chinese version-RNLI to measure WHO-ICF participation restriction among community-dwelling pre-frail and frail older people. A cross-sectional study was conducted in community and day-care centres in Hong Kong between May 2015 and January 2016. Through face-to-face interviews, information was collected on the participants' demographic background, medical history, frailty status, depressive mood, functional performance in daily activities, and participation restriction. The internal consistency, test-retest reliability, and construct and convergent validity of the C-RNLI were assessed. Two hundred and ninety-nine pre-frail or frail community-dwelling older people with a mean age of 79.53 were recruited. A confirmatory factor analysis showed that the C-RNLI has a two-factor structure comprised of "participation in physical activities" and "participation in social events". The test-retest coefficient was 0.71. The Cronbach's alpha of the total C-RNLI score, and those of the factors "participation in physical activities" and "participation in social events" were 0.88, 0.82 and 0.84, respectively. Pre-frail older people had significantly higher scores for the factors "participation in physical activities" (z = -5.05, <0.01) and "participation in social events" (z = -6.04, p < 0.01) than frail older people. Older people from community centres had significantly higher scores for the factors "participation in physical activities" (z = -4.48, <0.01) and "participation in social events" (z = -4.03, p < 0.01) than older people from day-care centres. The factors "participation in physical activities" and "participation in social events" of the C-RNLI were significantly convergent with depressive mood (r s = -0.25 and r s = -0.39, respectively) and functional performance in daily activities (r s = 0.28 and r s = 0.45, respectively). The C-RNLI is a two-factor structured scale with acceptable level of reliability and validity to measure WHO-ICF participation restriction among community-dwelling pre-frail and frail older people.
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Vazou, Spyridoula; Vlachopoulos, Symeon P
2014-11-01
Research on the motivation of stakeholders to integrate physical activity into daily school life is limited. The purpose was to examine the motivation of stakeholders to participate in a world record physical activity event and whether motivation was associated with future intention to use activity breaks during the daily school life and future participation in a similar event. After the 2012 JAM (Just-a-Minute) World Record event, 686 adults (591 women; 76.1% participated for children <10 years) completed measures of motivational regulations and future intention to (a) use the activity breaks and (b) participate in the event. High intrinsic motivation and low extrinsic motivation and amotivation for participation in the next event were reported. Hierarchical regression analysis, controlling for age, gender, and occupation, showed that intrinsic forms of motivation positively predicted, whereas amotivation negatively predicted, future intention to participate in the event and use the activity breaks. Multivariate analyses of variance revealed that school-related participants were more intrinsically motivated and intended to use the activity breaks and repeat the event more than those who were not affiliated with a school. Nonschool participants reported higher extrinsic motivation and amotivation than school-related participants. © 2014 Society for Public Health Education.
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Xing, Fuqiang; Zhan, Qiuqiang; He, Yiduo; Cui, Jiesheng; He, Sailing; Wang, Guanyu
2016-01-01
Recent studies have reported that exposure of mammalian cells to microwave radiation may have adverse effects such as induction of cell apoptosis. However, the molecular mechanisms underlying microwave induced mammalian cell apoptosis are not fully understood. Here, we report a novel mechanism: exposure to 1800MHz microwave radiation induces p53-dependent cell apoptosis through cytochrome c-mediated caspase-3 activation pathway. We first measured intensity of microwave radiation from several electronic devices with an irradiation detector. Mouse NIH/3T3 and human U-87 MG cells were then used as receivers of 1800MHz electromagnetic radiation (EMR) at a power density of 1209 mW/m2. Following EMR exposure, cells were analyzed for viability, intracellular reactive oxygen species (ROS) generation, DNA damage, p53 expression, and caspase-3 activity. Our analysis revealed that EMR exposure significantly decreased viability of NIH/3T3 and U-87 MG cells, and increased caspase-3 activity. ROS burst was observed at 6 h and 48 h in NIH/3T3 cells, while at 3 h in U-87 MG cells. Hoechst 33258 staining and in situ TUNEL assay detected that EMR exposure increased DNA damage, which was significantly restrained in the presence of N-acetyl-L-cysteine (NAC, an antioxidant). Moreover, EMR exposure increased the levels of p53 protein and p53 target gene expression, promoted cytochrome c release from mitochondrion, and increased caspase-3 activity. These events were inhibited by pretreatment with NAC, pifithrin-α (a p53 inhibitor) and caspase inhibitor. Collectively, our findings demonstrate, for the first time, that 1800MHz EMR induces apoptosis-related events such as ROS burst and more oxidative DNA damage, which in turn promote p53-dependent caspase-3 activation through release of cytochrome c from mitochondrion. These findings thus provide new insights into physiological mechanisms underlying microwave-induced cell apoptosis. PMID:27689798
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NASA Astrophysics Data System (ADS)
Dimitrova, S.; Mustafa, F. R.; Stoilova, I.; Babayev, E. S.; Kazimov, E. A.
2009-02-01
This collaborative study is based on the analysis and comparison of results of coordinated experimental investigations conducted in Bulgaria and Azerbaijan for revealing a possible influence of solar activity changes and related geomagnetic activity variations on the human cardio-vascular state. Arterial blood pressure and heart rate of 86 healthy volunteers were measured on working days during a period of comparatively high solar and geomagnetic activity (2799 measurements in autumn 2001 and spring 2002) in Sofia. Daily experimental investigations of parameters of cardio-vascular health state were performed in Azerbaijan with a permanent group of examined persons. Heart rate and electrocardiograms were digitally registered (in total 1532 records) for seven functionally healthy persons on working days and Saturdays, in the Laboratory of Heliobiology at the Medical Center INAM in Baku, from 15.07.2006 to 13.11.2007. Obtained digital recordings were subjected to medical, statistical and spectral analyses. Special attention was paid to effects of solar extreme events, particularly those of November 2001 and December 2006. The statistical method of the analysis of variance (ANOVA) and post hoc analysis were applied to check the significance of the influence of geomagnetic activity on the cardio-vascular parameters under consideration. Results revealed statistically significant increments for the mean systolic and diastolic blood pressure values of the group with geomagnetic activity increase. Arterial blood pressure values started increasing two days prior to geomagnetic storms and kept their high values up to two days after the storms. Heart rate reaction was ambiguous and not significant for healthy persons examined (for both groups) under conditions with geomagnetic activity changes. It is concluded that heart rate for healthy persons at middle latitudes can be considered as a more stable physiological parameter which is not so sensitive to environmental changes while the dynamics of arterial blood pressure reveals a compensatory reaction of the human organism for adaptation.
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Waller, Christiane; Wittfoth, Matthias; Fritzsche, Konstantin; Timm, Lydia; Wittfoth-Schardt, Dina; Rottler, Edit; Heinrichs, Markus; Buchheim, Anna; Kiefer, Markus; Gündel, Harald
2015-12-01
Oxytocin (OT) plays a crucial role in parental-infant bonding and attachment. Recent functional imaging studies reveal specific attachment and reward related brain regions in individuals or within the parent-child dyad. However, the time course and functional stage of modulatory effects of OT on attachment-related processing, especially in fathers, are poorly understood. To elucidate the functional and neural mechanisms underlying the role of OT in paternal-child attachment, we performed an event-related potential study in 24 healthy fathers who received intranasal OT in a double-blind, placebo-controlled, within-subject experimental design. Participants passively viewed pictures of their own child (oC), a familiar (fC) and an unfamiliar child (ufC) while event-related potentials were recorded. Familiarity of the child's face modulated a broad negativity at occipital and temporo-parietal electrodes within a time window of 300-400ms, presumably reflecting a modulation of the N250 and N300 ERP components. The oC condition elicited a more negative potential compared to the other familiarity conditions suggesting different activation of perceptual memory representations and assignment of emotional valence. Most importantly, this familiarity effect was only observed under placebo (PL) and was abolished under OT, in particular at left temporo-parietal electrodes. This OT induced attenuation of ERP responses was related to habitual attachment representations in fathers. In summary, our results demonstrate an OT-specific effect at later stages of attachment-related face processing presumably reflecting both activation of perceptual memory representations and assignment of emotional value. Copyright © 2015 Elsevier Ltd. All rights reserved.
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ICGC PedBrain: Dissecting the genomic complexity underlying medulloblastoma
Jones, David TW; Jäger, Natalie; Kool, Marcel; Zichner, Thomas; Hutter, Barbara; Sultan, Marc; Cho, Yoon-Jae; Pugh, Trevor J; Hovestadt, Volker; Stütz, Adrian M; Rausch, Tobias; Warnatz, Hans-Jörg; Ryzhova, Marina; Bender, Sebastian; Sturm, Dominik; Pleier, Sabrina; Cin, Huriye; Pfaff, Elke; Sieber, Laura; Wittmann, Andrea; Remke, Marc; Witt, Hendrik; Hutter, Sonja; Tzaridis, Theophilos; Weischenfeldt, Joachim; Raeder, Benjamin; Avci, Meryem; Amstislavskiy, Vyacheslav; Zapatka, Marc; Weber, Ursula D; Wang, Qi; Lasitschka, Bärbel; Bartholomae, Cynthia C; Schmidt, Manfred; von Kalle, Christof; Ast, Volker; Lawerenz, Chris; Eils, Jürgen; Kabbe, Rolf; Benes, Vladimir; van Sluis, Peter; Koster, Jan; Volckmann, Richard; Shih, David; Betts, Matthew J; Russell, Robert B; Coco, Simona; Tonini, Gian Paolo; Schüller, Ulrich; Hans, Volkmar; Graf, Norbert; Kim, Yoo-Jin; Monoranu, Camelia; Roggendorf, Wolfgang; Unterberg, Andreas; Herold-Mende, Christel; Milde, Till; Kulozik, Andreas E; von Deimling, Andreas; Witt, Olaf; Maass, Eberhard; Rössler, Jochen; Ebinger, Martin; Schuhmann, Martin U; Frühwald, Michael C; Hasselblatt, Martin; Jabado, Nada; Rutkowski, Stefan; von Bueren, André O; Williamson, Dan; Clifford, Steven C; McCabe, Martin G; Collins, V. Peter; Wolf, Stephan; Wiemann, Stefan; Lehrach, Hans; Brors, Benedikt; Scheurlen, Wolfram; Felsberg, Jörg; Reifenberger, Guido; Northcott, Paul A; Taylor, Michael D; Meyerson, Matthew; Pomeroy, Scott L; Yaspo, Marie-Laure; Korbel, Jan O; Korshunov, Andrey; Eils, Roland; Pfister, Stefan M; Lichter, Peter
2013-01-01
Summary Medulloblastoma is an aggressively-growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and displays tremendous biological and clinical heterogeneity1. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles are currently discriminated2,3. WNT tumours, displaying activated wingless pathway signalling, carry a favourable prognosis under current treatment regimens4. SHH tumours show hedgehog pathway activation, and have an intermediate prognosis2. Group 3 & 4 tumours are molecularly less well-characterised, and also present the greatest clinical challenges2,3,5. The full repertoire of genetic events driving this distinction, however, remains unclear. Here we describe an integrative deep-sequencing analysis of 125 tumour-normal pairs. Tetraploidy was identified as a frequent early event in Group 3 & 4 tumours, and a positive correlation between patient age and mutation rate was observed. Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns. RNA-sequencing confirmed these alterations, and revealed the expression of the first medulloblastoma fusion genes. Chromatin modifiers were frequently altered across all subgroups. These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 & 4 patients. PMID:22832583
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Metusalem, Ross; Kutas, Marta; Urbach, Thomas P; Elman, Jeffrey L
2016-04-01
During incremental language comprehension, the brain activates knowledge of described events, including knowledge elements that constitute semantic anomalies in their linguistic context. The present study investigates hemispheric asymmetries in this process, with the aim of advancing our understanding of the neural basis and functional properties of event knowledge activation during incremental comprehension. In a visual half-field event-related brain potential (ERP) experiment, participants read brief discourses in which the third sentence contained a word that was either highly expected, semantically anomalous but related to the described event (Event-Related), or semantically anomalous but unrelated to the described event (Event-Unrelated). For both visual fields of target word presentation, semantically anomalous words elicited N400 ERP components of greater amplitude than did expected words. Crucially, Event-Related anomalous words elicited a reduced N400 relative to Event-Unrelated anomalous words only with left visual field/right hemisphere presentation. This result suggests that right hemisphere processes are critical to the activation of event knowledge elements that violate the linguistic context, and in doing so informs existing theories of hemispheric asymmetries in semantic processing during language comprehension. Additionally, this finding coincides with past research suggesting a crucial role for the right hemisphere in elaborative inference generation, raises interesting questions regarding hemispheric coordination in generating event-specific linguistic expectancies, and more generally highlights the possibility of functional dissociation of event knowledge activation for the generation of elaborative inferences and for linguistic expectancies. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Seismic activity of Tokyo area and Philippine Sea plate under Japanese Islands
NASA Astrophysics Data System (ADS)
Sakai, S.; Nakagawa, S.; Nanjo, K.; Kasahara, K.; Panayotopoulos, Y.; Tsuruoka, H.; Kurashimo, E.; Obara, K.; Hirata, N.; Kimura, H.; Honda, R.
2012-12-01
The Japanese government has estimated the probability of earthquake occurrence with magnitude 7-class during the next 30 years as 70 %. This estimation is based on five earthquakes that occurred in this area in the late 120 years. However, it has been revealed that this region is lying on more complicated tectonic condition due to the two subducted plates and the various types of earthquakes which have been caused by. Therefore, it is necessary to classify these earthquakes into inter-plate earthquakes and intra-plate ones. Then, we have been constructing a seismic observation network since 5 years ago. Tokyo Metropolitan area is a densely populated region of about 40 million people. It is the center of Japan both in politics and in economy. So that human activities have been conducting quite busily, this region is unsuitable for seismic observation. Then, we have decided to make an ultra high dense seismic observation network. We named it the Metropolitan Seismometer Observation Network; MeSO-net. MeSO-net consists of 296 seismic stations. Minimum interval is about 2km and average interval is about 5km.We picked the P- and S-wave arrival times manually. We applied double-difference tomography method to the dataset and estimated the velocity structure. We depicted the plate boundaries from the newly developed velocity model. And, we referred to the locations of the repeating earthquakes, the distributions of normal hypocenters and the focal mechanisms. Our plate model became relatively flat and a little shallower than previous one.Seismicity of Metropolitan area after the M9 event was compared to the one before M9 event. The seismic activity is about 4 times as high as before the M9 event occurred. We examined spatial distribution of the activated seismicity with respect to the newly developed plate configuration. The activated events are located on upper boundaries and they have almost thrust type mechanisms. Recently, a slow slip event has occurred on October in 2011. This observation suggests that shear stresses on the plate boundaries have increased due to eastwards movement of the eastern Japan driven by post-seismic slip of the M9.0 Tohoku-oki event. The present study is supported by two Special Projects for Earthquake Disaster Mitigation in Tokyo Metropolitan Area and reducing vulnerability for urban mega earthquake disasters from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
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NASA Astrophysics Data System (ADS)
Takaya, Y.; Kubo, Y.; Yamaguchi, M.; Vitart, F.; Hirahara, S.; Maeda, S.
2016-12-01
Strong El Niño events have lingering effects on the seasonal variability in the Indo- western Pacific region in the mature-decay phase of El Niño. Specifically, in the decay phase, a low-level anticyclonic circulation and suppressed convection in the western North Pacific are enforced as a result of a local air-sea feedback in the western North Pacific and remote response to the Indian Ocean warming due to El Niño. The typhoon activity in the western North Pacific is also modulated by the lingering effects in the early typhoon season (boreal spring to early summer) following the strong El Niño events. This study investigates underlying mechanisms and predictability by analyzing the historical analysis data, subseasonal and seasonal reforecast data, and sensitivity experiments with the use of an atmosphere-ocean coupled model for the 2016 typhoon season. In this study, we focus on the remote response of the typhoon activity in the Indo-Pacific region. First, we examined the case of 2016, which exhibited the striking inactive typhoon activity and marked the second latest genesis of the first typhoon of the year since 1977 (Typhoon Nipartak on 3 July 2016). The inactive typhoon activity in the early typhoon season of 2016 is plausibly related to the lingering effects of the preceding strong El Niño in 2015/2016 winter. And the inactive typhoon condition and its related atmosphere-ocean conditions in the western north Pacific were successfully predicted with sub-seasonal prediction systems and JMA seasonal prediction system (JMA/MRI-CPS2) well in advance. A composite analysis using historical analysis data indicates that the typhoon activity tends to be suppressed associated with the Indian Ocean warming in boreal spring to summer following El Niño winters. This is relatively well replicated in reforecasts of JMA/MRI-CPS2. We also carried out sensitivity experiments with JMA/MRI-CPS2, where we strongly nudge sea surface temperature (SST) in the Indian Ocean to climatological SST. The typhoon activity in the western North Pacific is enhanced in the sensitivity experiment, implying that the the Indian Ocean played a role in shaping the inactive typhoon conditions in the 2016 typhoon season. We will further discuss the underlying mechanisms and predictability using the series of experiments.
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Teprotumumab for Thyroid-Associated Ophthalmopathy
Smith, Terry J.; Kahaly, George J.; Ezra, Daniel G.; Fleming, James C.; Dailey, Roger A.; Tang, Rosa A.; Harris, Gerald J.; Antonelli, Alessandro; Salvi, Mario; Goldberg, Robert A.; Gigantelli, James W.; Couch, Steven M.; Shriver, Erin M.; Hayek, Brent R.; Hink, Eric M.; Woodward, Richard M.; Gabriel, Kathleen; Magni, Guido; Douglas, Raymond S.
2017-01-01
BACKGROUND Thyroid-associated ophthalmopathy, a condition commonly associated with Graves’ disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy. A total of 88 patients were randomly assigned to receive placebo or active drug administered intravenously once every 3 weeks for a total of eight infusions. The primary end point was the response in the study eye. This response was defined as a reduction of 2 points or more in the Clinical Activity Score (scores range from 0 to 7, with a score of ≥3 indicating active thyroid-associated ophthalmopathy) and a reduction of 2 mm or more in proptosis at week 24. Secondary end points, measured as continuous variables, included proptosis, the Clinical Activity Score, and results on the Graves’ ophthalmopathy–specific quality-of-life questionnaire. Adverse events were assessed. RESULTS In the intention-to-treat population, 29 of 42 patients who received teprotumumab (69%), as compared with 9 of 45 patients who received placebo (20%), had a response at week 24 (P<0.001). Therapeutic effects were rapid; at week 6, a total of 18 of 42 patients in the teprotumumab group (43%) and 2 of 45 patients in the placebo group (4%) had a response (P<0.001). Differences between the groups increased at subsequent time points. The only drug-related adverse event was hyperglycemia in patients with diabetes; this event was controlled by adjusting medication for diabetes. CONCLUSIONS In patients with active ophthalmopathy, teprotumumab was more effective than placebo in reducing proptosis and the Clinical Activity Score. (Funded by River Vision Development and others; ClinicalTrials.gov number, NCT01868997.) PMID:28467880
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Extreme Events in China under Climate Change: Uncertainty and related impacts (CSSP-FOREX)
NASA Astrophysics Data System (ADS)
Leckebusch, Gregor C.; Befort, Daniel J.; Hodges, Kevin I.
2016-04-01
Suitable adaptation strategies or the timely initiation of related mitigation efforts in East Asia will strongly depend on robust and comprehensive information about future near-term as well as long-term potential changes in the climate system. Therefore, understanding the driving mechanisms associated with the East Asian climate is of major importance. The FOREX project (Fostering Regional Decision Making by the Assessment of Uncertainties of Future Regional Extremes and their Linkage to Global Climate System Variability for China and East Asia) focuses on the investigation of extreme wind and rainfall related events over Eastern Asia and their possible future changes. Here, analyses focus on the link between local extreme events and their driving weather systems. This includes the coupling between local rainfall extremes and tropical cyclones, the Meiyu frontal system, extra-tropical teleconnections and monsoonal activity. Furthermore, the relation between these driving weather systems and large-scale variability modes, e.g. NAO, PDO, ENSO is analysed. Thus, beside analysing future changes of local extreme events, the temporal variability of their driving weather systems and related large-scale variability modes will be assessed in current CMIP5 global model simulations to obtain more robust results. Beyond an overview of FOREX itself, first results regarding the link between local extremes and their steering weather systems based on observational and reanalysis data are shown. Special focus is laid on the contribution of monsoonal activity, tropical cyclones and the Meiyu frontal system on the inter-annual variability of the East Asian summer rainfall.
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Ganachaud, Alexandre; Vega, Andrés; Rodier, Martine; Dupouy, Cécile; Maes, Christophe; Marchesiello, Patrick; Eldin, Gerard; Ridgway, Ken; Le Borgne, Robert
2010-01-01
The upwelling events that follow strong trade wind episodes have been described in terms of their remarkable signature in the sea surface temperature southwest off New Caledonia. Upwelling brings deeper, and colder waters to the surface, causing 2-4 degrees C drops in temperature in a few hours, followed by a slower relaxation over several days. Upwelling may sporadically bring nutrients to the surface under certain conditions, and increase the biological productivity. Two multidisciplinary hydrographic cruises allow the impact of upwelling on the chemical and biological properties of the water to be documented. Both cruises took place in austral summer (December 2004 and December 2005), but the first cruise occurred during a strong upwelling event, while the second cruise occurred in calm conditions. The water properties and planktonic composition show important contrasts, with a strong southeastward current (the "ALIS current of New Caledonia") competing with the upwelling system. Our analysis suggests that, while observed productivities are far less than those of typical upwelling systems, some wind events in New Caledonia may contribute to biological activity. A currentmeter mooring, deployed during the second cruise, documents the ocean response to a changing wind field and the local impact of upwelling on currents and temperatures on the water column. The results are discussed, with the help of climatology, Argo float profiler data, satellite data and of a high-resolution numerical simulation. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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"Under the radar": nurse practitioner prescribers and pharmaceutical industry promotions.
Ladd, Elissa C; Mahoney, Diane Feeney; Emani, Srinivas
2010-12-01
To assess nurse practitioners' interactions with pharmaceutical industry promotional activities and their perception of information reliability and self-reported prescribing behaviors. Self-administered online survey. A nationally randomized sample of nurse practitioner prescribers was surveyed. Eligibility criteria included current clinical practice and licensure to prescribe medications in their state of practice. A total of 263 responses were analyzed. Almost all respondents (96%) reported regular contact with pharmaceutical sales representatives, and most (71%) reported receiving information on new drugs directly from pharmaceutical sales representatives some or most of the time. A large portion (66%) dispensed drug samples regularly to their patients, and 73% believed that samples were somewhat or very helpful in learning about new drugs. Eighty-one percent of respondents thought that it was ethically acceptable to give out samples to anyone, and 90% believed that it was acceptable to attend lunch and dinner events sponsored by the pharmaceutical industry. Almost half (48%) stated that they were more likely to prescribe a drug that was highlighted during a lunch or dinner event. Most respondents stated that it was ethically acceptable for speakers to be paid by industry. Nurse practitioner prescribers had extensive contact with pharmaceutical industry promotional activities such as pharmaceutical representative contact, receipt of drug samples, and regular attendance at industry-sponsored meal events and continuing education programs. They reported that industry interface with nurse practitioner prescribers in the form of sponsored meals, education events, and paid speakers was ethically acceptable.
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Barber, Horacio A; Kousta, Stavroula-Thaleia; Otten, Leun J; Vigliocco, Gabriella
2010-05-21
A number of recent studies have provided contradictory evidence on the question of whether grammatical class plays a role in the neural representation of lexical knowledge. Most of the previous studies comparing the processing of nouns and verbs, however, confounded word meaning and grammatical class by comparing verbs referring to actions with nouns referring to objects. Here, we recorded electrical brain activity from native Italian speakers reading single words all referring to events (e.g., corsa [the run]; correre [to run]), thus avoiding confounding nouns and verbs with objects and actions. We manipulated grammatical class (noun versus verb) as well as semantic attributes (motor versus sensory events). Activity between 300 and 450ms was more negative for nouns than verbs, and for sensory than motor words, over posterior scalp sites. These grammatical class and semantic effects were not dissociable in terms of latency, duration, or scalp distribution. In a later time window (450-110ms) and at frontal regions, grammatical class and semantic effects interacted; motor verbs were more positive than the other three word categories. We suggest that the lack of a temporal and topographical dissociation between grammatical class and semantic effects in the time range of the N400 component is compatible with an account in which both effects reflect the same underlying process related to meaning retrieval, and we link the later effect with working memory operations associated to the experimental task. Copyright 2010 Elsevier B.V. All rights reserved.
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NASA Astrophysics Data System (ADS)
Jonsdottir, K.; Vogfjord, K. S.; Bean, C. J.; Martini, F.
2013-12-01
The glacier overlain Katla volcano in South Iceland, is one of the most active and hazardous volcano in Europe. Katla eruptions result in hazardous glacial floods and intense tephra fall. On average there are eruptions every 50 years but the volcano is long overdue and we are now witnessing the longest quiescence period in 1000 years or since the settlement. Because of the hazard the volcano poses, it is under constant surveillance and gets a good share of the seismic stations from the national seismic network. Every year the seismic network records thousands of seismic events at Katla with magnitudes seldom exceeding M3. The bulk of the seismicity is however not due to volcano tectonics but seems to be caused mainly by shallow processes involving glacial deformation. Katla's ice filled caldera forms a glacier plateau of several hundred meters thick ice. The 9x14 km oval caldera is surrounded by higher rims where the glacier in some places gently and in others abruptly falls off tens and up to hundred meters to the surrounding lowland. The glacier surface is marked with dozen depressions or cauldrons which manifest geothermal activity below, probably coinciding with circular faults around the caldera. Our current understanding is that there are several glacial processes which cause seismicity; these include dry calving, where steep valley glaciers fall off cliffs and movements of glacier ice as the cauldrons deform due to hydraulic changes and geothermal activity at the glacier/bedrock boundary. These glacial events share a common feature of containing low frequency (2-4 hz) and long coda. Because of their shallow origin, surface waves are prominent. In our analysis we use waveforms from all of Katla's seismic events between years 2003-2013, with the criteria M>1 and minimum 4 p-wave picks. We correlate the waveforms of these events with each other and group them into families of highly similar events. Looking at the occurrence of these families we find that individual families are usually clustered in time over several months, and sometimes families may reappear even up to several years later. Using families including many events and covering long periods (10-20 months) we compare the coda (the tail) of individual events within a family. This is repeated for all the surrounding stations. The analysis, coda wave interferometry (cwi) is a correlation method that builds on the fact that changes in stress in the edifice lead to changes in seismic velocities. The coda waves are highly sensitive to small stress changes. By using a repeating source, implying we have the same source mechanism and the same path, we can track temporal stress changes in the medium between the source and the receiver. Preliminary results from Katla suggest that by using the repeating glacial events and the coda wave interferometry technique we observe annual seismic velocity changes around the volcano of ca. 0.7%. We find that seismic velocities increase from January through July and decrease in August to December. These changes can be explained by pore-water pressure changes and/or loading and de-loading of the overlain glacier. We do not find immediate precursors for an impending eruption at Katla; however we now have a better understanding of its background seismicity.
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Failure of hippocampal deactivation during loss events in treatment-resistant depression.
Johnston, Blair A; Tolomeo, Serenella; Gradin, Victoria; Christmas, David; Matthews, Keith; Steele, J Douglas
2015-09-01
Major depressive disorder is characterized by anhedonia, cognitive biases, ruminations, hopelessness and increased anxiety. Blunted responses to rewards have been reported in a number of recent neuroimaging and behavioural studies of major depressive disorder. In contrast, neural responses to aversive events remain an under-studied area. While selective serotonergic reuptake inhibitors are often effective in treating major depressive disorder, their mechanism of action remains unclear. Following a series of animal model investigations of depressive illness and serotonergic function, Deakin and Graeff predicted that brain activity in patients with major depressive disorder is associated with an overactive dorsal raphe nucleus with overactive projections to the amygdala, periaqueductal grey and striatum, and an underactive median raphe nucleus with underactive projections to the hippocampus. Here we describe an instrumental loss-avoidance and win-gain reinforcement learning functional magnetic resonance imaging study with 40 patients with highly treatment-resistant major depressive disorder and never-depressed controls. The dorsal raphe nucleus/ periaqueductal grey region of the midbrain and hippocampus were found to be overactive in major depressive disorder during unsuccessful loss-avoidance although the median raphe nucleus was not found to be underactive. Hippocampal overactivity was due to a failure to deactivate during loss events in comparison to controls, and hippocampal over-activity correlated with depression severity, self-report 'hopelessness' and anxiety. Deakin and Graeff argued that the median raphe nucleus normally acts to inhibit consolidation of aversive memories via the hippocampus and this system is underactive in major depressive disorder, facilitating the development of ruminations, while the dorsal raphe nucleus system is engaged by distal cues predictive of threats and is overactive in major depressive disorder. During win events the striatum was underactive in major depressive disorder. We tested individual patient consistency of these findings using within-study replication. Abnormal hippocampal activity correctly predicted individual patient diagnostic status in 97% (sensitivity 95%, specificity 100%) of subjects, and abnormal striatal activity predicted diagnostic status in 84% (sensitivity 79%, specificity 89%) of subjects. We conclude that the neuroimaging findings were largely consistent with Deaken and Graeff's predictions, abnormally increased hippocampal activity during loss events was an especially consistent abnormality, and brainstem serotonergic nuclei merit further study in depressive illness. © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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29 CFR 4043.27 - Distribution to a substantial owner.
Code of Federal Regulations, 2014 CFR
2014-07-01
... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...
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29 CFR 4043.27 - Distribution to a substantial owner.
Code of Federal Regulations, 2011 CFR
2011-07-01
... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...
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29 CFR 4043.27 - Distribution to a substantial owner.
Code of Federal Regulations, 2013 CFR
2013-07-01
... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...
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29 CFR 4043.27 - Distribution to a substantial owner.
Code of Federal Regulations, 2010 CFR
2010-07-01
... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...
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29 CFR 4043.27 - Distribution to a substantial owner.
Code of Federal Regulations, 2012 CFR
2012-07-01
... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...
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Temporal clustering of tropical cyclones and its ecosystem impacts
Mumby, Peter J.; Vitolo, Renato; Stephenson, David B.
2011-01-01
Tropical cyclones have massive economic, social, and ecological impacts, and models of their occurrence influence many planning activities from setting insurance premiums to conservation planning. Most impact models allow for geographically varying cyclone rates but assume that individual storm events occur randomly with constant rate in time. This study analyzes the statistical properties of Atlantic tropical cyclones and shows that local cyclone counts vary in time, with periods of elevated activity followed by relative quiescence. Such temporal clustering is particularly strong in the Caribbean Sea, along the coasts of Belize, Honduras, Costa Rica, Jamaica, the southwest of Haiti, and in the main hurricane development region in the North Atlantic between Africa and the Caribbean. Failing to recognize this natural nonstationarity in cyclone rates can give inaccurate impact predictions. We demonstrate this by exploring cyclone impacts on coral reefs. For a given cyclone rate, we find that clustered events have a less detrimental impact than independent random events. Predictions using a standard random hurricane model were overly pessimistic, predicting reef degradation more than a decade earlier than that expected under clustered disturbance. The presence of clustering allows coral reefs more time to recover to healthier states, but the impacts of clustering will vary from one ecosystem to another. PMID:22006300
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The Neural Basis of Event Simulation: An fMRI Study
Yomogida, Yukihito; Sugiura, Motoaki; Akimoto, Yoritaka; Miyauchi, Carlos Makoto; Kawashima, Ryuta
2014-01-01
Event simulation (ES) is the situational inference process in which perceived event features such as objects, agents, and actions are associated in the brain to represent the whole situation. ES provides a common basis for various cognitive processes, such as perceptual prediction, situational understanding/prediction, and social cognition (such as mentalizing/trait inference). Here, functional magnetic resonance imaging was used to elucidate the neural substrates underlying important subdivisions within ES. First, the study investigated whether ES depends on different neural substrates when it is conducted explicitly and implicitly. Second, the existence of neural substrates specific to the future-prediction component of ES was assessed. Subjects were shown contextually related object pictures implying a situation and performed several picture–word-matching tasks. By varying task goals, subjects were made to infer the implied situation implicitly/explicitly or predict the future consequence of that situation. The results indicate that, whereas implicit ES activated the lateral prefrontal cortex and medial/lateral parietal cortex, explicit ES activated the medial prefrontal cortex, posterior cingulate cortex, and medial/lateral temporal cortex. Additionally, the left temporoparietal junction plays an important role in the future-prediction component of ES. These findings enrich our understanding of the neural substrates of the implicit/explicit/predictive aspects of ES-related cognitive processes. PMID:24789353
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Event segmentation improves event memory up to one month later.
Flores, Shaney; Bailey, Heather R; Eisenberg, Michelle L; Zacks, Jeffrey M
2017-08-01
When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the events. If segmenting events effectively leads to better memory, does asking people to attend to segmentation improve subsequent memory? To answer this question, participants viewed movies of naturalistic activity with instructions to remember the activity for a later test, and in some conditions additionally pressed a button to segment the movies into meaningful events or performed a control condition that required button-pressing but not attending to segmentation. In 5 experiments, memory for the movies was assessed at intervals ranging from immediately following viewing to 1 month later. Performing the event segmentation task led to superior memory at delays ranging from 10 min to 1 month. Further, individual differences in segmentation ability predicted individual differences in memory performance for up to a month following encoding. This study provides the first evidence that manipulating event segmentation affects memory over long delays and that individual differences in event segmentation are related to differences in memory over long delays. These effects suggest that attending to how an activity breaks down into meaningful events contributes to memory formation. Instructing people to more effectively segment events may serve as a potential intervention to alleviate everyday memory complaints in aging and clinical populations. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
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Quantifying Discrete Fracture Network Connectivity in Hydraulic Fracturing Stimulation
NASA Astrophysics Data System (ADS)
Urbancic, T.; Ardakani, E. P.; Baig, A.
2017-12-01
Hydraulic fracture stimulations generally result in microseismicity that is associated with the activation or extension of pre-existing microfractures and discontinuities. Microseismic events acquired under 3D downhole sensor coverage provide accurate event locations outlining hydraulic fracture growth. Combined with source characteristics, these events provide a high quality input for seismic moment tensor inversion and eventually constructing the representative discrete fracture network (DFN). In this study, we investigate the strain and stress state, identified fracture orientation, and DFN connectivity and performance for example stages in a multistage perf and plug completion in a North American shale play. We use topology, the familiar concept in many areas of structural geology, to further describe the relationships between the activated fractures and their effectiveness in enhancing permeability. We explore how local perturbations of stress state lead to the activation of different fractures sets and how that effects the DFN interaction and complexity. In particular, we observe that a more heterogeneous stress state shows a higher percentage of sub-horizontal fractures or bedding plane slips. Based on topology, the fractures are evenly distributed from the injection point, with decreasing numbers of connections by distance. The dimensionless measure of connection per branch and connection per line are used for quantifying the DFN connectivity. In order to connect the concept of connectivity back to productive volume and stimulation efficiency, the connectivity is compared with the character of deformation in the reservoir as deduced from the collective behavior of microseismicity using robustly determined source parameters.
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Forero, Luis Gabriel; Limay-Rios, Victor; Xue, Yingen; Schaafsma, Arthur
2017-12-01
Atmospheric emissions of neonicotinoid seed treatment insecticides as particulate matter in field crops occur mainly for two reasons: 1) due to abraded dust of treated seed generated during planting using vacuum planters, and 2) as a result of disturbances (tillage or wind events) in the surface of parental soils which release wind erodible soil-bound residues. In the present study, concentration and movement of neonicotinoids as particulate matter were quantified under real conditions using passive and active air samplers. Average neonicotinoid concentrations in Total Suspended Particulate (TSP) using passive samplers were 0.48 ng/cm 2 , trace, trace (LOD 0.80 and 0.04 ng/cm 2 for clothianidin and thiamethoxam, respectively), and using active samplers 16.22, 1.91 and 0.61 ng/m 3 during planting, tillage and wind events, respectively. There was a difference between events on total neonicotinoid concentration collected in particulate matter using either passive or active sampling. Distance of sampling from the source field during planting of treated seed had an effect on total neonicotinoid air concentration. However, during tillage distance did not present an effect on measured concentrations. Using hypothetical scenarios, values of contact exposure for a honey bee were estimated to be in the range from 1.1% to 36.4% of the reference contact LD 50 value of clothianidin of 44 ng/bee. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
Koliopoulos, Marios G; Esposito, Diego; Christodoulou, Evangelos; Taylor, Ian A; Rittinger, Katrin
2016-06-01
TRIM E3 ubiquitin ligases regulate a wide variety of cellular processes and are particularly important during innate immune signalling events. They are characterized by a conserved tripartite motif in their N-terminal portion which comprises a canonical RING domain, one or two B-box domains and a coiled-coil region that mediates ligase dimerization. Self-association via the coiled-coil has been suggested to be crucial for catalytic activity of TRIMs; however, the precise molecular mechanism underlying this observation remains elusive. Here, we provide a detailed characterization of the TRIM ligases TRIM25 and TRIM32 and show how their oligomeric state is linked to catalytic activity. The crystal structure of a complex between the TRIM25 RING domain and an ubiquitin-loaded E2 identifies the structural and mechanistic features that promote a closed E2~Ub conformation to activate the thioester for ubiquitin transfer allowing us to propose a model for the regulation of activity in the full-length protein. Our data reveal an unexpected diversity in the self-association mechanism of TRIMs that might be crucial for their biological function. © 2016 Francis Crick Institute. Published under the terms of the CC BY 4.0 license.
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Temporal dynamics of musical emotions examined through intersubject synchrony of brain activity
Frühholz, Sascha; Cochrane, Tom; Cojan, Yann; Vuilleumier, Patrik
2015-01-01
To study emotional reactions to music, it is important to consider the temporal dynamics of both affective responses and underlying brain activity. Here, we investigated emotions induced by music using functional magnetic resonance imaging (fMRI) with a data-driven approach based on intersubject correlations (ISC). This method allowed us to identify moments in the music that produced similar brain activity (i.e. synchrony) among listeners under relatively natural listening conditions. Continuous ratings of subjective pleasantness and arousal elicited by the music were also obtained for the music outside of the scanner. Our results reveal synchronous activations in left amygdala, left insula and right caudate nucleus that were associated with higher arousal, whereas positive valence ratings correlated with decreases in amygdala and caudate activity. Additional analyses showed that synchronous amygdala responses were driven by energy-related features in the music such as root mean square and dissonance, while synchrony in insula was additionally sensitive to acoustic event density. Intersubject synchrony also occurred in the left nucleus accumbens, a region critically implicated in reward processing. Our study demonstrates the feasibility and usefulness of an approach based on ISC to explore the temporal dynamics of music perception and emotion in naturalistic conditions. PMID:25994970
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Robust non-parametric one-sample tests for the analysis of recurrent events.
Rebora, Paola; Galimberti, Stefania; Valsecchi, Maria Grazia
2010-12-30
One-sample non-parametric tests are proposed here for inference on recurring events. The focus is on the marginal mean function of events and the basis for inference is the standardized distance between the observed and the expected number of events under a specified reference rate. Different weights are considered in order to account for various types of alternative hypotheses on the mean function of the recurrent events process. A robust version and a stratified version of the test are also proposed. The performance of these tests was investigated through simulation studies under various underlying event generation processes, such as homogeneous and nonhomogeneous Poisson processes, autoregressive and renewal processes, with and without frailty effects. The robust versions of the test have been shown to be suitable in a wide variety of event generating processes. The motivating context is a study on gene therapy in a very rare immunodeficiency in children, where a major end-point is the recurrence of severe infections. Robust non-parametric one-sample tests for recurrent events can be useful to assess efficacy and especially safety in non-randomized studies or in epidemiological studies for comparison with a standard population. Copyright © 2010 John Wiley & Sons, Ltd.
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NASA Astrophysics Data System (ADS)
Bauwe, Andreas; Tiemeyer, Bärbel; Kahle, Petra; Lennartz, Bernd
2015-12-01
Nitrate is one of the most important sources of pollution for surface waters in tile-drained agricultural areas. In order to develop appropriate management strategies to reduce nitrate losses, it is crucial to first understand the underlying hydrological processes. In this study, we used Principle Component Analysis (PCA) and Linear Discriminant Analysis (LDA) to analyze 212 discharge events between 2004 and 2011 across three spatial scales (68 events at the collector drain, 72 at the ditch, and 72 at the brook) to identify the controlling factors for hydrograph response characteristics and their influence on nitrate concentration patterns. Our results showed that the 212 hydrological events can be classified into six different types: summer events (28%), snow-dominated events (10%), events controlled by rainfall duration (16%), rainfall totals (8%), dry antecedent conditions (10%), and events controlled by wet antecedent conditions (14%). The relatively large number of unclassified events (15%) demonstrated the difficulty in separating event types due to mutually influencing variables. NO3-N concentrations showed a remarkably consistent pattern during the discharge events regardless of event type, with minima at the beginning, increasing concentrations at the rising limb, and maxima around peak discharge. However, the level of NO3-N concentrations varied notably among the event types. The highest average NO3-N concentrations were found for events controlled by rainfall totals (NO3-N = 17.1 mg/l), events controlled by wet antecedent conditions (NO3-N = 17.1 mg/l), and snowmelt (NO3-N = 15.2 mg/l). Average maximum NO3-N concentrations were significantly lower during summer events (NO3-N = 10.2 mg/l) and events controlled by dry antecedent conditions (NO3-N = 11.7 mg/l). The results have furthermore shown that similar hydrological and biogeochemical processes determine the hydrograph and NO3-N response on storm events at various spatial scales. The management of tile-drained agricultural land to reduce NO3-N losses should focus explicitly on flow events and, more specifically, active management should preferably be conducted in the winter season for discharge events after snowmelt, after heavy rain storms and when the soil moisture conditions are wet.
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The high precision measurement of the 144Ce activity in the SOX experiment
NASA Astrophysics Data System (ADS)
Di Noto, L.; Agostini,
M.; Althenmüller, K.; Appel, S.; Bellini, G.; Benziger, J.; Berton, N.; Bick, D.; Bonfini, G.; Bravo—Berguño, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Cereseto, R.; Chepurnov, A.; Choi, K.; Cribier, M.; DAngelo, D.; Davini, S.; Derbin, A.; Drachnev, I.; Durero, M.; Etenko, A.; Farinon, S.; Fischer, V.; Fomenko, K.; Franco, D.; Gabriele, F.; Gaffiot, J.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Göeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Houdy, Th; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jonquères, N.; Jedrzejczak, K.; Kaiser, M.; Kobychev, V.; Korablev, D.; Korga, G.; Kornoukhov, V.; Kryn, D.; Lachenmaier, T.; Lasserre, T.; Laubenstein, M.; Lehnert, T.; Link, J.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Maricic, J.; Mention, G.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Musenich, R.; Neumair, B.; Oberauer, L.; Obolensky, M.; Ortica, F.; Pallavicini, M.; Papp, L.; Perasso, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Roncin, R.; Rossi, C.; Rossi, N.; Schönert, S.; Scola, L.; Semenov, D.; Simgen, H.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Veyssière, C.; Vivier, M.; Unzhakov, E.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G. 2016-02-01
In order to perform a resolutive measurement to clarify the neutrino anomalies and to observe possible short distance neutrino oscillations, the SOX (Short distance neutrino Oscillations with BoreXino) experiment is under construction. In the first phase, a 100 kCi 144Ce-144Pr antineutrino source will be placed under the Borexino detector at the Laboratori Nazionali del Gran Sasso (LNGS), in center of Italy, and the rate measurement of the antineutrino events, observed by the very low radioactive background Borexino detector, will be compared with the high precision (< 1%) activity measurement performed by two calorimeters. The source will be embedded in a 19 mm thick tungsten alloy shield and both the calorimeters have been conceived for measuring the thermal heat absorbed by a water flow. In this report the design of the calorimeters will be described in detail and very preliminary results will be also shown.
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Effect of External Electric Field on Substrate Transport of a Secondary Active Transporter.
Zhang, Ji-Long; Zheng, Qing-Chuan; Yu, Li-Ying; Li, Zheng-Qiang; Zhang, Hong-Xing
2016-08-22
Substrate transport across a membrane accomplished by a secondary active transporter (SAT) is essential to the normal physiological function of living cells. In the present research, a series of all-atom molecular dynamics (MD) simulations under different electric field (EF) strengths was performed to investigate the effect of an external EF on the substrate transport of an SAT. The results show that EF both affects the interaction between substrate and related protein's residues by changing their conformations and tunes the timeline of the transport event, which collectively reduces the height of energy barrier for substrate transport and results in the appearance of two intermediate conformations under the existence of an external EF. Our work spotlights the crucial influence of external EFs on the substrate transport of SATs and could provide a more penetrating understanding of the substrate transport mechanism of SATs.
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Dimasi, Annalisa; Rasponi, Marco; Consolo, Filippo; Fiore, Gianfranco B; Bluestein, Danny; Slepian, Marvin J; Redaelli, Alberto
2017-10-01
Thrombus formation is a major adverse event affecting patients implanted with ventricular assist devices (VADs). Despite anti-thrombotic drug administration, thrombotic events remain frequent within the first year post-implantation. Platelet activation (PA) is an essential process underling thrombotic adverse events in VAD systems. Indeed, abnormal shear forces, correlating with specific flow trajectories of VADs, are strong agonists mediating PA. To date, the ability to determine efficacy of anti-platelet (AP) agents under shear stress conditions is limited. Here, we present a novel microfluidic platform designed to replicate shear stress patterns of a clinical VAD, and use it to compare the efficacy of two AP agents in vitro. Gel-filtered platelets were incubated with i) acetylsalicylic acid (ASA) and ii) ticagrelor, at two different concentrations (ASA: 125 and 250 µM; ticagrelor: 250 and 500 nM) and were circulated in the VAD-emulating microfluidic platform using a peristaltic pump. GFP was collected after 4 and 52 repetitions of exposure to the VAD shear pattern and tested for shear-mediated PA. ASA significantly inhibited PA only at 2-fold higher concentration (250 µM) than therapeutic dose (125 µM). The effect of ticagrelor was not dependent on drug concentration, and did not show significant inhibition with respect to untreated control. This study demonstrates the potential use of microfluidic platforms as means of testing platelet responsiveness and AP drug efficacy under complex and realistic VAD-like shear stress conditions. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.
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Maund, Emma; Tendal, Britta; Hróbjartsson, Asbjørn; Lundh, Andreas; Gøtzsche, Peter C
2014-06-04
To assess the effects of coding and coding conventions on summaries and tabulations of adverse events data on suicidality within clinical study reports. Systematic electronic search for adverse events of suicidality in tables, narratives, and listings of adverse events in individual patients within clinical study reports. Where possible, for each event we extracted the original term reported by the investigator, the term as coded by the medical coding dictionary, medical coding dictionary used, and the patient's trial identification number. Using the patient's trial identification number, we attempted to reconcile data on the same event between the different formats for presenting data on adverse events within the clinical study report. 9 randomised placebo controlled trials of duloxetine for major depressive disorder submitted to the European Medicines Agency for marketing approval. Clinical study reports obtained from the EMA in 2011. Six trials used the medical coding dictionary COSTART (Coding Symbols for a Thesaurus of Adverse Reaction Terms) and three used MedDRA (Medical Dictionary for Regulatory Activities). Suicides were clearly identifiable in all formats of adverse event data in clinical study reports. Suicide attempts presented in tables included both definitive and provisional diagnoses. Suicidal ideation and preparatory behaviour were obscured in some tables owing to the lack of specificity of the medical coding dictionary, especially COSTART. Furthermore, we found one event of suicidal ideation described in narrative text that was absent from tables and adverse event listings of individual patients. The reason for this is unclear, but may be due to the coding conventions used. Data on adverse events in tables in clinical study reports may not accurately represent the underlying patient data because of the medical dictionaries and coding conventions used. In clinical study reports, the listings of adverse events for individual patients and narratives of adverse events can provide additional information, including original investigator reported adverse event terms, which can enable a more accurate estimate of harms. © Maund et al 2014.
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Event-related wave activity in the EEG provides new marker of ADHD.
Alexander, David M; Hermens, Daniel F; Keage, Hannah A D; Clark, C Richard; Williams, Leanne M; Kohn, Michael R; Clarke, Simon D; Lamb, Chris; Gordon, Evian
2008-01-01
This study examines the utility of new measures of event-related spatio-temporal waves in the EEG as a marker of ADHD, previously shown to be closely related to the P3 ERP in an adult sample. Wave activity in the EEG was assessed during both an auditory Oddball and a visual continuous performance task (CPT) for an ADHD group ranging in age from 6 to 18 years and comprising mostly Combined and Inattentive subtypes, and for an age and gender matched control group. The ADHD subjects had less wave activity at low frequencies ( approximately 1 Hz) during both tasks. For auditory Oddball targets, this effect was shown to be related to smaller P3 ERP amplitudes. During CPT, the approximately 1 Hz wave activity in the ADHD subjects was inversely related to clinical and behavioral measures of hyperactivity and impulsivity. CPT wave activity at approximately 1 Hz was seen to "normalise" following treatment with stimulant medication. The results identify a deficit in low frequency wave activity as a new marker for ADHD associated with levels of hyperactivity and impulsivity. The marker is evident across a range of tasks and may be specific to ADHD. While lower approximately 1 Hz activity partly accounts for reduced P3 ERPs in ADHD, the effect also arises for tasks that do not elicit a P3. Deficits in behavioral inhibition are hypothesized to arise from underlying dysregulation of cortical inhibition.
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Vrij, Anton A; Oberndorff-Klein-Woolthuis, Ardi; Dijkstra, Gerard; de Jong, Andrea E; Wagenvoord, Rob; Hemker, Hendrik C; Stockbrügger, Reinhold W
2007-10-01
In ulcerative colitis (UC), a state of hypercoagulation has frequently been observed. Low molecular weight heparin (LMWH) has shown beneficial effects as an adjuvant treatment of steroid refractory UC in open trials. We assessed potential therapeutic effects of the LMWH reviparin in hospitalised patients with mesalazine refractory UC, as well as its influence on haemostasis factors. Twenty-nine patients with mild-to-moderately active UC were included in a double-blind placebo controlled trial. All patients had a flare-up of disease under mesalazine treatment. Reviparin (Clivarin) 3,436 IU anti-Xa/0.6 ml or placebo s.c. was added, and self-administered twice daily for 8 weeks. Patients were monitored for possible adverse events and changes in clinical symptoms. Endoscopical, histological, biochemical and haemostasis parameters were analysed. Tolerability and compliance were excellent and no serious adverse events occurred. No significant differences were observed on the clinical, endoscopical and histological outcome, as compared to placebo. A high intrinsic and extrinsic thrombin potential was found before LMWH therapy. However, the significant reduction in the thrombin generation by LMWH was not related to the reduction in disease activity. The LMWH reviparine reduces thrombin generation in patients with mild-to-moderately active, mesalazine refractory UC, but is not associated with a reduction in disease activity.
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Reichel, Christoph A.; Lerchenberger, Max; Uhl, Bernd; Rehberg, Markus; Berberich, Nina; Zahler, Stefan; Wymann, Matthias P.; Krombach, Fritz
2011-01-01
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear. Using in vivo microscopy on the cremaster muscle of male C57BL/6 mice, aprotinin as well as inhibitors of the serine protease plasmin including tranexamic acid and ε-aminocaproic acid were found to significantly diminish I/R-elicited intravascular firm adherence and (subsequent) transmigration of neutrophils. Remodeling of collagen IV within the postischemic perivenular basement membrane was almost completely abrogated in animals treated with plasmin inhibitors or aprotinin. In separate experiments, incubation with plasmin did not directly activate neutrophils. Extravascular, but not intravascular administration of plasmin caused a dose-dependent increase in numbers of firmly adherent and transmigrated neutrophils. Blockade of mast cell activation as well as inhibition of leukotriene synthesis or antagonism of the platelet-activating-factor receptor significantly reduced plasmin-dependent neutrophil responses. In conclusion, our data suggest that extravasated plasmin(ogen) mediates neutrophil recruitment in vivo via activation of perivascular mast cells and secondary generation of lipid mediators. Aprotinin as well as the plasmin inhibitors tranexamic acid and ε-aminocaproic acid interfere with this inflammatory cascade and effectively prevent postischemic neutrophil responses as well as remodeling events within the vessel wall. PMID:21364954
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Fudge, Jessie
2016-01-01
Context: Hypothermia and frostbite injuries occur in cold weather activities and sporting events. Evidence Acquisition: A PubMed search was used to identify original research and review articles related to cold, frostbite, and hypothermia. Inclusion was based on their relevance to prevention and treatment of cold-related injuries in sports and outdoor activities. Dates of review articles were limited to those published after 2010. No date limit was set for the most recent consensus statements or original research. Study Design: Clinical review. Level of Evidence: Level 5. Results: Frostbite and hypothermia are well-documented entities with good prevention strategies and prehospital treatment recommendations that have changed very little with time. A layered approach to clothing is the best way to prevent injury and respond to weather changes. Each athlete, defined as a participant in a cold weather sport or activity, will respond to cold differently depending on anthropometric measurements and underlying medical risk factors. An understanding of wind-chill temperatures, wetness, and the weather forecast allows athletes and event coordinators to properly respond to changing weather conditions. At the first sign of a freezing cold injury, ensure warm, dry clothes and move to a protected environment. Conclusion: Cold injuries can be prevented, and cold weather activities are safe with proper education, preparation, and response to changing weather conditions or injury. PMID:26857732
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NASA Astrophysics Data System (ADS)
Diffenbaugh, N. S.; Horton, D. E.; Singh, D.; Swain, D. L.; Touma, D. E.; Mankin, J. S.
2015-12-01
Because of the high cost of extreme events and the growing evidence that global warming is likely to alter the statistical distribution of climate variables, detection and attribution of changes in the probability of extreme climate events has become a pressing topic for the scientific community, elected officials, and the public. While most of the emphasis has thus far focused on analyzing the climate variable of interest (most often temperature or precipitation, but also flooding and drought), there is an emerging emphasis on applying detection and attribution analysis techniques to the underlying physical causes of individual extreme events. This approach is promising in part because the underlying physical causes (such as atmospheric circulation patterns) can in some cases be more accurately represented in climate models than the more proximal climate variable (such as precipitation). In addition, and more scientifically critical, is the fact that the most extreme events result from a rare combination of interacting causes, often referred to as "ingredients". Rare events will therefore always have a strong influence of "natural" variability. Analyzing the underlying physical mechanisms can therefore help to test whether there have been changes in the probability of the constituent conditions of an individual event, or whether the co-occurrence of causal conditions cannot be distinguished from random chance. This presentation will review approaches to applying detection/attribution analysis to the underlying physical causes of extreme events (including both "thermodynamic" and "dynamic" causes), and provide a number of case studies, including the role of frequency of atmospheric circulation patterns in the probability of hot, cold, wet and dry events.
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[Molecular mechanisms of thymocyte differentiation].
Kuklina, E M
2003-01-01
A review of the main molecular events occurring during differentiation of T-lymphocytes in the thymus: T-cell specialization of early intrathymic precursors, formation and expression of antigen receptor, formation of antigen recognizing cell repertoire, and alpha beta/gamma beta- and CD4/CD8-commitment. The mechanisms of glucocorticoid-induced apoptosis of thymocytes and its blockade during antigen-dependent activation are considered. A special attention is paid to the analysis of intracellular signals underlying the clonal selection of thymocytes.
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2012-07-03
of white noise vectors with square sumable coefficients and components with finite fourth order moments (Shumway et al., 1999). Here, the infrasonic...center in a star -like configuration for reducing the background noise from wind activity along the boundary layer. Sensor data is recorded by 24-bit...the PMCC Algorithm In Figure 19, under the assumption that the source (red star ) is far from the arrays, PMCC starts coherence processing using
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Toward an automated signature recognition toolkit for mission operations
NASA Technical Reports Server (NTRS)
Cleghorn, T.; Laird, P; Perrine, L.; Culbert, C.; Macha, M.; Saul, R.; Hammen, D.; Moebes, T.; Shelton, R.
1994-01-01
Signature recognition is the problem of identifying an event or events from its time series. The generic problem has numerous applications to science and engineering. At NASA's Johnson Space Center, for example, mission control personnel, using electronic displays and strip chart recorders, monitor telemetry data from three-phase electrical buses on the Space Shuttle and maintain records of device activation and deactivation. Since few electrical devices have sensors to indicate their actual status, changes of state are inferred from characteristic current and voltage fluctuations. Controllers recognize these events both by examining the waveform signatures and by listening to audio channels between ground and crew. Recently the authors have developed a prototype system that identifies major electrical events from the telemetry and displays them on a workstation. Eventually the system will be able to identify accurately the signatures of over fifty distinct events in real time, while contending with noise, intermittent loss of signal, overlapping events, and other complications. This system is just one of many possible signature recognition applications in Mission Control. While much of the technology underlying these applications is the same, each application has unique data characteristics, and every control position has its own interface and performance requirements. There is a need, therefore, for CASE tools that can reduce the time to implement a running signature recognition application from months to weeks or days. This paper describes our work to date and our future plans.
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Toward an automated signature recognition toolkit for mission operations
NASA Astrophysics Data System (ADS)
Cleghorn, T.; Laird, P.; Perrine, L.; Culbert, C.; Macha, M.; Saul, R.; Hammen, D.; Moebes, T.; Shelton, R.
1994-10-01
Signature recognition is the problem of identifying an event or events from its time series. The generic problem has numerous applications to science and engineering. At NASA's Johnson Space Center, for example, mission control personnel, using electronic displays and strip chart recorders, monitor telemetry data from three-phase electrical buses on the Space Shuttle and maintain records of device activation and deactivation. Since few electrical devices have sensors to indicate their actual status, changes of state are inferred from characteristic current and voltage fluctuations. Controllers recognize these events both by examining the waveform signatures and by listening to audio channels between ground and crew. Recently the authors have developed a prototype system that identifies major electrical events from the telemetry and displays them on a workstation. Eventually the system will be able to identify accurately the signatures of over fifty distinct events in real time, while contending with noise, intermittent loss of signal, overlapping events, and other complications. This system is just one of many possible signature recognition applications in Mission Control. While much of the technology underlying these applications is the same, each application has unique data characteristics, and every control position has its own interface and performance requirements. There is a need, therefore, for CASE tools that can reduce the time to implement a running signature recognition application from months to weeks or days. This paper describes our work to date and our future plans.
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NASA Astrophysics Data System (ADS)
Strikis, N. M.; Cruz, F. W.; Cheng, H.; Karmann, I.; Vuille, M.; Edwards, R.; Wang, X.; Paula, M. S.; Novello, V. F.; Auler, A.
2011-12-01
A paleoprecipitation reconstruction based on high resolution and well-dated speleothem oxygen isotope records shows that the monsoon precipitation over central eastern Brazil underwent to strong variations on millennial to multi-centennial time-scales during the Holocene. This new record indicates that abrupt events of increase in monsoon precipitation are correlated to Bond events 6, 5 and 4 and also with 8.2 ky event during the early and mid-Holocene, with a mean amplitude of 1.5 % (PDB). The pacing and structure of such events are general consistent with variations in solar activity suggested by atmospheric Δ14 C records. In the late-Holocene, abrupt events of increase in monsoon precipitation peaking at 3.2, 2.7 and 2.3 ky B.P. are approximately synchronous with periods of low solar minima. In this regard, the most prominent event occurred during the late Holocene occurred at ~2.7 ky B.P. In addition, these positive anomalies of the precipitation recorded in central eastern Brazil are also in good agreement with variations in Titicaca lake level. The good correspondence between the speleothem and marine records imply that the variations in the north Atlantic sea surface temperature is the main forcing for abrupt millennial to multi-centennial precipitations variation within the region under influence of South American Monsoon.
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Preparedness and response to terrorism: a framework for public health action.
Gofin, Rosa
2005-02-01
Political group violence in the form of terrorist actions has become a reality worldwide, affecting the health and economies of populations. As a consequence, preparedness and response are becoming an integral part of public health action. Risk appraisal, preservation of human and civil rights and communications within and between countries are all issues to be considered in the process. The combination of the natural history of terrorist actions and the epidemiological triangle model has been adapted in this paper and suggested as a comprehensive approach for preparedness and action. It covers preparedness (pre-event), response (event) and the consequences (post-event) of a terrorist attack. It takes into account the human factor, vectors and environment involved in each one of the phases. Terrorism is a global reality with varying underlying causes, manifestations and impact on the health of the public. Preparedness, response and rehabilitation are an integral part of public health action. Consideration of the pre-event, event and post-event phases in terrorist actions, together with the human factor, vector/agent and environment in each of these phases, offers a framework for public health preparedness, response and rehabilitation. Planning should consider risk assessment, risk communication, inter-sectorial cooperation, enactment of laws and regulations which consider protection of the public's health and civil liberties. Allocation of resources would need to make allowance for maintenance and development of ongoing public health activities.
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Analysis and asynchronous detection of gradually unfolding errors during monitoring tasks
NASA Astrophysics Data System (ADS)
Omedes, Jason; Iturrate, Iñaki; Minguez, Javier; Montesano, Luis
2015-10-01
Human studies on cognitive control processes rely on tasks involving sudden-onset stimuli, which allow the analysis of these neural imprints to be time-locked and relative to the stimuli onset. Human perceptual decisions, however, comprise continuous processes where evidence accumulates until reaching a boundary. Surpassing the boundary leads to a decision where measured brain responses are associated to an internal, unknown onset. The lack of this onset for gradual stimuli hinders both the analyses of brain activity and the training of detectors. This paper studies electroencephalographic (EEG)-measurable signatures of human processing for sudden and gradual cognitive processes represented as a trajectory mismatch under a monitoring task. Time-locked potentials and brain-source analysis of the EEG of sudden mismatches revealed the typical components of event-related potentials and the involvement of brain structures related to cognitive control processing. For gradual mismatch events, time-locked analyses did not show any discernible EEG scalp pattern, despite related brain areas being, to a lesser extent, activated. However, and thanks to the use of non-linear pattern recognition algorithms, it is possible to train an asynchronous detector on sudden events and use it to detect gradual mismatches, as well as obtaining an estimate of their unknown onset. Post-hoc time-locked scalp and brain-source analyses revealed that the EEG patterns of detected gradual mismatches originated in brain areas related to cognitive control processing. This indicates that gradual events induce latency in the evaluation process but that similar brain mechanisms are present in sudden and gradual mismatch events. Furthermore, the proposed asynchronous detection model widens the scope of applications of brain-machine interfaces to other gradual processes.
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Automatic Classification of volcano-seismic events based on Deep Neural Networks.
NASA Astrophysics Data System (ADS)
Titos Luzón, M.; Bueno Rodriguez, A.; Garcia Martinez, L.; Benitez, C.; Ibáñez, J. M.
2017-12-01
Seismic monitoring of active volcanoes is a popular remote sensing technique to detect seismic activity, often associated to energy exchanges between the volcano and the environment. As a result, seismographs register a wide range of volcano-seismic signals that reflect the nature and underlying physics of volcanic processes. Machine learning and signal processing techniques provide an appropriate framework to analyze such data. In this research, we propose a new classification framework for seismic events based on deep neural networks. Deep neural networks are composed by multiple processing layers, and can discover intrinsic patterns from the data itself. Internal parameters can be initialized using a greedy unsupervised pre-training stage, leading to an efficient training of fully connected architectures. We aim to determine the robustness of these architectures as classifiers of seven different types of seismic events recorded at "Volcán de Fuego" (Colima, Mexico). Two deep neural networks with different pre-training strategies are studied: stacked denoising autoencoder and deep belief networks. Results are compared to existing machine learning algorithms (SVM, Random Forest, Multilayer Perceptron). We used 5 LPC coefficients over three non-overlapping segments as training features in order to characterize temporal evolution, avoid redundancy and encode the signal, regardless of its duration. Experimental results show that deep architectures can classify seismic events with higher accuracy than classical algorithms, attaining up to 92% recognition accuracy. Pre-training initialization helps these models to detect events that occur simultaneously in time (such explosions and rockfalls), increase robustness against noisy inputs, and provide better generalization. These results demonstrate deep neural networks are robust classifiers, and can be deployed in real-environments to monitor the seismicity of restless volcanoes.
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Evolution of fractality in space plasmas of interest to geomagnetic activity
NASA Astrophysics Data System (ADS)
Muñoz, Víctor; Domínguez, Macarena; Alejandro Valdivia, Juan; Good, Simon; Nigro, Giuseppina; Carbone, Vincenzo
2018-03-01
We studied the temporal evolution of fractality for geomagnetic activity, by calculating fractal dimensions from the Dst data and from a magnetohydrodynamic shell model for turbulent magnetized plasma, which may be a useful model to study geomagnetic activity under solar wind forcing. We show that the shell model is able to reproduce the relationship between the fractal dimension and the occurrence of dissipative events, but only in a certain region of viscosity and resistivity values. We also present preliminary results of the application of these ideas to the study of the magnetic field time series in the solar wind during magnetic clouds, which suggest that it is possible, by means of the fractal dimension, to characterize the complexity of the magnetic cloud structure.
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Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models
2017-01-01
Chemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recruitment, and resolution phases of cardiovascular disease progression. Activation of leukocytes via inflammatory mediators such as chemokines, cytokines, and adhesion molecules is instrumental in these processes. In this review, we highlight leukocyte activation with the main focus being on the mechanisms of chemokine-mediated recruitment in atherosclerosis and the response postmyocardial infarction with key examples from experimental models of cardiovascular inflammation. PMID:28465628
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Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models.
Jones, Daniel P; True, Harry D; Patel, Jyoti
2017-01-01
Chemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recruitment, and resolution phases of cardiovascular disease progression. Activation of leukocytes via inflammatory mediators such as chemokines, cytokines, and adhesion molecules is instrumental in these processes. In this review, we highlight leukocyte activation with the main focus being on the mechanisms of chemokine-mediated recruitment in atherosclerosis and the response postmyocardial infarction with key examples from experimental models of cardiovascular inflammation.
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Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy
Wu, Zhi-Qiang; Shi, Yang-Yang; Zaorsky, Nicholas G.; Deng, Lei; Yuan, Zhi-Yong; Lu, You; Wang, Ping
2016-01-01
While the mechanisms underlying apoptosis and autophagy have been well characterized over recent decades, another regulated cell death event, necroptosis, remains poorly understood. Elucidating the signaling networks involved in the regulation of necroptosis may allow this form of regulated cell death to be exploited for diagnosis and treatment of cancer, and will contribute to the understanding of the complex tumor microenvironment. In this review, we have summarized the mechanisms and regulation of necroptosis, the converging and diverging features of necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy, as well as attempts to exploit this newly gained knowledge to provide therapeutics for cancer. PMID:27429198
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Hidayat, D.; Chouet, B.; Voight, B.; Dawson, P.; Ratdomopurbo, Antonius
2002-01-01
Very-long-period (VLP) pulses with period of 6-7s, displaying similar waveforms, were identified in 1998 from broadband seismographs around the summit crater. These pulses accompanied most of multiphase (MP) earthquakes, a type of long-period event locally defined at Merapi Volcano. Source mechanisms for several VLP pulses were examined by applying moment tensor inversion to the waveform data. Solutions were consistent with a crack striking ???70?? and dipping ???50?? SW, 100m under the active dome, suggest pressurized gas transport involving accumulation and sudden release of 10-60 m3 of gas in the crack over a 6s interval.
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Experience-dependent development of spinal motor neurons
NASA Technical Reports Server (NTRS)
Inglis, F. M.; Zuckerman, K. E.; Kalb, R. G.; Walton, K. D. (Principal Investigator)
2000-01-01
Locomotor activity in many species undergoes pronounced alterations in early postnatal life, and environmental cues may be responsible for modifying this process. To determine how these events are reflected in the nervous system, we studied rats reared under two different conditions-the presence or absence of gravity-in which the performance of motor operations differed. We found a significant effect of rearing environment on the size and complexity of dendritic architecture of spinal motor neurons, particularly those that are likely to participate in postural control. These results provide evidence that neurons subserving motor function undergo activity-dependent maturation in early postnatal life in a manner analogous to sensory systems.
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Santamaría, Abel; Vázquez-Román, Beatriz; La Cruz, Verónica Pérez-De; González-Cortés, Carolina; Trejo-Solís, Ma Cristina; Galván-Arzate, Sonia; Jara-Prado, Aurelio; Guevara-Fonseca, Jorge; Ali, Syed F
2005-12-15
Quinolinate (QUIN) neurotoxicity has been attributed to degenerative events in nerve tissue produced by sustained activation of N-methyl-D-aspartate receptor (NMDAr) and oxidative stress. We have recently described the protective effects that selenium (Se), an antioxidant, produces on different markers of QUIN-induced neurotoxicity (Santamaría et al., 2003, J Neurochem 86:479-488.). However, the mechanisms by which Se exerts its protective actions remain unclear. Since some of these events are thought to be related with inhibition of deadly molecular cascades through the activation of antioxidant selenoproteins, in this study we investigated the effects of Se on QUIN-induced cell damage elicited by the nuclear factor kappaB (NF-kappaB) pathway, as well as the time-course response of striatal glutathione peroxidase (GPx) activity. Se (sodium selenite, 0.625 mg/kg/day, i.p.) was administered to rats for 5 days, and 120 min after the last administration, animals received a single striatal injection of QUIN (240 nmol/mul). Twenty-four hours later, their striata were tested for the expression of IkappaB-alpha (the NF-kappaB cytosolic binding protein), the immunohistochemical expression of NF-kappaB (evidenced as nuclear expression of P65), caspase-3-like activation, and DNA fragmentation. Additional groups were killed at 2, 6, and 24 h for measurement of GPx activity. Se reduced the QUIN-induced decrease in IkappaB-alpha expression, evidencing a reduction in its cytosolic degradation. Se also prevented the QUIN-induced increase in P65-immunoreactive cells, suggesting a reduction of NF-kappaB nuclear translocation. Caspase-3-like activation and DNA fragmentation produced by QUIN were also inhibited by Se. Striatal GPx activity was stimulated by Se at 2 and 6 h, but not at 24 h postlesion. Altogether, these data suggest that the protective effects exerted by Se on QUIN-induced neurotoxicity are partially mediated by the inhibition of proapoptotic events underlying IkappaB-alpha degradation, NF-kappaB nuclear translocation, and caspase-3-like activation in the rat striatum, probably involving the early activation of GPx.
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High density event-related potential data acquisition in cognitive neuroscience.
Slotnick, Scott D
2010-04-16
Functional magnetic resonance imaging (fMRI) is currently the standard method of evaluating brain function in the field of Cognitive Neuroscience, in part because fMRI data acquisition and analysis techniques are readily available. Because fMRI has excellent spatial resolution but poor temporal resolution, this method can only be used to identify the spatial location of brain activity associated with a given cognitive process (and reveals virtually nothing about the time course of brain activity). By contrast, event-related potential (ERP) recording, a method that is used much less frequently than fMRI, has excellent temporal resolution and thus can track rapid temporal modulations in neural activity. Unfortunately, ERPs are under utilized in Cognitive Neuroscience because data acquisition techniques are not readily available and low density ERP recording has poor spatial resolution. In an effort to foster the increased use of ERPs in Cognitive Neuroscience, the present article details key techniques involved in high density ERP data acquisition. Critically, high density ERPs offer the promise of excellent temporal resolution and good spatial resolution (or excellent spatial resolution if coupled with fMRI), which is necessary to capture the spatial-temporal dynamics of human brain function.
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Jalleh, Geoffrey; Anwar-McHenry, Julia; Donovan, Robert J; Laws, Amberlee
2013-04-01
A primary aim of the pilot phase of the Act-Belong-Commit mental health promotion campaign was to form partnerships with community organisations. As a component of the broader campaign strategy, collaborating organisations promoted their activities under the Act-Belong-Commit banner in exchange for resources, promotional opportunities and capacity building in event management and funding. The impact of the Act-Belong-Commit campaign on the capacity and activities of collaborating organisations during the pilot phase was evaluated using self-completed mail surveys in 2006 and 2008. Collaboration with the campaign had a positive impact on community organisations' capacity, including staff expertise, media publicity and funding applications. Collaborating organisations had strong positive perceptions of Act-Belong-Commit officers and all expressed a willingness to collaborate in future events and activities. The partnership model used during the pilot phase of the Act-Belong-Commit campaign was successful in creating mutually beneficial exchanges with collaborating organisations. So what? Community partnerships are necessary for the effective delivery of mental health promotion campaigns at a local level. Successful partnerships involve the provision of real and valuable benefits to collaborating organisations in return for their cooperation in promoting health messages.
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Kunz, Alexander; Abe, Takato; Hochrainer, Karin; Shimamura, Munehisa; Anrather, Josef; Racchumi, Gianfranco; Zhou, Ping; Iadecola, Costantino
2008-02-13
CD36, a class-B scavenger receptor involved in multiple functions, including inflammatory signaling, may also contribute to ischemic brain injury through yet unidentified mechanisms. We investigated whether CD36 participates in the molecular events underlying the inflammatory reaction that accompanies cerebral ischemia and may contribute to the tissue damage. We found that activation of nuclear factor-kappaB, a transcription factor that coordinates postischemic gene expression, is attenuated in CD36-null mice subjected to middle cerebral artery occlusion. The infiltration of neutrophils and the glial reaction induced by cerebral ischemia were suppressed. Treatment with an inhibitor of inducible nitric oxide synthase, an enzyme that contributes to the tissue damage, reduced ischemic brain injury in wild-type mice, but not in CD36 nulls. In contrast to cerebral ischemia, the molecular and cellular inflammatory changes induced by intracerebroventricular injection of interleukin-1beta were not attenuated in CD36-null mice. The findings unveil a novel role of CD36 in early molecular events leading to nuclear factor-kappaB activation and postischemic inflammation. Inhibition of CD36 signaling may be a valuable therapeutic approach to counteract the deleterious effects of postischemic inflammation.
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Sato, Wataru; Kochiyama, Takanori; Uono, Shota; Yoshimura, Sayaka; Toichi, Motomi
2017-01-01
Impaired joint attention represents the core clinical feature of autism spectrum disorder (ASD). Behavioral studies have suggested that gaze-triggered attentional orienting is intact in response to supraliminally presented eyes but impaired in response to subliminally presented eyes in individuals with ASD. However, the neural mechanisms underlying conscious and unconscious gaze-triggered attentional orienting remain unclear. We investigated this issue in ASD and typically developing (TD) individuals using event-related functional magnetic resonance imaging. The participants viewed cue stimuli of averted or straight eye gaze direction presented either supraliminally or subliminally and then localized a target. Reaction times were shorter when eye-gaze cues were directionally valid compared with when they were neutral under the supraliminal condition in both groups; the same pattern was found in the TD group but not the ASD group under the subliminal condition. The temporo–parieto–frontal regions showed stronger activation in response to averted eyes than to straight eyes in both groups under the supraliminal condition. The left amygdala was more activated while viewing averted vs. straight eyes in the TD group than in the ASD group under the subliminal condition. These findings provide an explanation for the neural mechanisms underlying the impairment in unconscious but not conscious gaze-triggered attentional orienting in individuals with ASD and suggest possible neurological and behavioral interventions to facilitate their joint attention behaviors. PMID:28701942
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Evidence for holistic episodic recollection via hippocampal pattern completion.
Horner, Aidan J; Bisby, James A; Bush, Daniel; Lin, Wen-Jing; Burgess, Neil
2015-07-02
Recollection is thought to be the hallmark of episodic memory. Here we provide evidence that the hippocampus binds together the diverse elements forming an event, allowing holistic recollection via pattern completion of all elements. Participants learn complex 'events' from multiple overlapping pairs of elements, and are tested on all pairwise associations. At encoding, element 'types' (locations, people and objects/animals) produce activation in distinct neocortical regions, while hippocampal activity predicts memory performance for all within-event pairs. When retrieving a pairwise association, neocortical activity corresponding to all event elements is reinstated, including those incidental to the task. Participant's degree of incidental reinstatement correlates with their hippocampal activity. Our results suggest that event elements, represented in distinct neocortical regions, are bound into coherent 'event engrams' in the hippocampus that enable episodic recollection--the re-experiencing or holistic retrieval of all aspects of an event--via a process of hippocampal pattern completion and neocortical reinstatement.
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NASA Astrophysics Data System (ADS)
Bauwe, Andreas; Tiemeyer, Bärbel; Kahle, Petra; Lennartz, Bernd
2015-04-01
Nitrate is one of the most important sources of pollution for surface waters in tile-drained agricultural areas. In order to develop appropriate management strategies to reduce nitrate losses, it is crucial to first understand the underlying hydrological processes. In this study, we used Principle Component Analysis (PCA) and Linear Discriminant Analysis (LDA) to analyze 212 storm events between 2004 and 2011 across three spatial scales (collector drain, ditch, and brook) to identify the controlling factors for hydrograph response characteristics and their influence on nitrate concentration patterns. Our results showed that the 212 hydrological events can be classified into six different types: summer events (28%), snow-dominated events (10%), events controlled by rainfall duration (16%), rainfall totals (8%), dry antecedent conditions (10%), and events controlled by wet antecedent conditions (14%). The relatively large number of unclassified events (15%) demonstrated the difficulty in separating event types due to mutually influencing variables. NO3-N concentrations showed a remarkably consistent pattern during the discharge events regardless of event type, with minima at the beginning, increasing concentrations at the rising limb, and maxima around peak discharge. However, the level of NO3-N concentrations varied notably among the event types. The highest average NO3-N concentrations were found for events controlled by rainfall totals (NO3-N=17.1 mg/l), events controlled by wet antecedent conditions (NO3-N=17.1 mg/l), and snowmelt (NO3-N=15.2 mg/l). Average maximum NO3-N concentrations were significantly lower during summer events (NO3-N=10.2 mg/l) and events controlled by dry antecedent conditions (NO3-N=11.7 mg/l). The results have furthermore shown that similar hydrological and biogeochemical processes determine the hydrograph and NO3-N response on storm events at various spatial scales. The management of tile-drained agricultural land to reduce NO3-N losses should focus explicitly on flow events and, more specifically, active management should preferably be conducted in the winter season for discharge events after snowmelt, after heavy rain storms and when the soil moisture conditions are wet.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Hajra, Rajkumar; Echer, Ezequiel; Gonzalez, Walter D.
2015-01-20
Radiation-belt relativistic (E > 0.6, > 2.0, and > 4.0 MeV) electron acceleration is studied for solar cycle 23 (1995-2008). High-intensity, long-duration, continuous AE activity (HILDCAA) events are considered as the basis of the analyses. All of the 35 HILDCAA events under study were found to be characterized by flux enhancements of magnetospheric relativistic electrons of all three energies compared to the pre-event flux levels. For the E > 2.0 MeV electron fluxes, enhancement of >50% occurred during 100% of HILDCAAs. Cluster-4 passes were examined for electromagnetic chorus waves in the 5 < L < 10 and 0 < MLT < 12more » region when wave data were available. Fully 100% of these HILDCAA cases were associated with enhanced whistler-mode chorus waves. The enhancements of E > 0.6, > 2.0, and > 4.0 MeV electrons occurred ∼1.0 day, ∼1.5 days, and ∼2.5 days after the statistical HILDCAA onset, respectively. The statistical acceleration rates for the three energy ranges were ∼1.8 × 10{sup 5}, 2.2 × 10{sup 3}, and 1.0 × 10{sup 1} cm{sup –2} s{sup –1} sr{sup –1} d{sup –1}, respectively. The relativistic electron-decay timescales were determined to be ∼7.7, 5.5, and 4.0 days for the three energy ranges, respectively. The HILDCAAs were divided into short-duration (D ≤ 3 days) and long-duration (D > 3 days) events to study the dependence of relativistic electron variation on HILDCAA duration. For long-duration events, the flux enhancements during HILDCAAs with respect to pre-event fluxes were ∼290%, 520%, and 82% for E > 0.6, > 2.0, and > 4.0 MeV electrons, respectively. The enhancements were ∼250%, 400%, and 27% respectively, for short-duration events. The results are discussed with respect to the current understanding of radiation-belt dynamics.« less
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ERIC Educational Resources Information Center
Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken
2009-01-01
An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or…
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Characteristics of mineral dust impacting the Persian Gulf
NASA Astrophysics Data System (ADS)
Ahmady-Birgani, Hesam; McQueen, Kenneth G.; Mirnejad, Hassan
2018-02-01
It is generally assumed that severe dust events in western Iran could be responsible for elevated levels of toxic and radioactive elements in the region. Over a period of 5 months, from January 2012 to May 2012, dust particles in the size range PM10 (i.e. <10 μm) were collected at Abadan, a site beside the Persian Gulf. The research aim was to compare chemical compositions of dust and aerosol samples collected during the non-dusty periods and during two severe dust events. Results of ICP-MS analysis of components indicate that during dust events the concentrations of major elements such as Ca, Mg, Al and K increase relative to ambient conditions when Fe and trace elements such as Cu, Cr, Ni, Pb and Zn are in higher proportions. Toxic trace elements that are generally ascribed to human activities, including industrial and urban pollution, are thus proportionately more abundant in the dust under calm conditions than during dust events, when their concentration is diluted by more abundant mineral particles of quartz, calcite and clay. The variability of chemical species during two dust events, noted by tracking the dust plumes in satellite images, was also assessed and the results relate to two different source areas, namely northern Iraq and northwestern Syria.
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Neural correlates of processing "self-conscious" vs. "basic" emotions.
Gilead, Michael; Katzir, Maayan; Eyal, Tal; Liberman, Nira
2016-01-29
Self-conscious emotions are prevalent in our daily lives and play an important role in both normal and pathological behavior. Despite their immense significance, the neural substrates that are involved in the processing of such emotions are surprisingly under-studied. In light of this, we conducted an fMRI study in which participants thought of various personal events which elicited feelings of negative and positive self-conscious (i.e., guilt, pride) or basic (i.e., anger, joy) emotions. We performed a conjunction analysis to investigate the neural correlates associated with processing events that are related to self-conscious vs. basic emotions, irrespective of valence. The results show that processing self-conscious emotions resulted in activation within frontal areas associated with self-processing and self-control, namely, the mPFC extending to the dACC, and within the lateral-dorsal prefrontal cortex. Processing basic emotions resulted in activation throughout relatively phylogenetically-ancient regions of the cortex, namely in visual and tactile processing areas and in the insular cortex. Furthermore, self-conscious emotions differentially activated the mPFC such that the negative self-conscious emotion (guilt) was associated with a more dorsal activation, and the positive self-conscious emotion (pride) was associated with a more ventral activation. We discuss how these results shed light on the nature of mental representations and neural systems involved in self-reflective and affective processing. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Baidwan, Sartaj; Chekuri, Anil; Hynds, DiAnna L; Kowluru, Anjaneyulu
2017-11-01
Emerging evidence suggests that long-term exposure of insulin-secreting pancreatic β-cells to hyperglycemic (HG; glucotoxic) conditions promotes oxidative stress, which, in turn, leads to stress kinase activation, mitochondrial dysfunction, loss of nuclear structure and integrity and cell apoptosis. Original observations from our laboratory have proposed that Rac1 plays a key regulatory role in the generation of oxidative stress and downstream signaling events culminating in the onset of dysfunction of pancreatic β-cells under the duress of metabolic stress. However, precise molecular and cellular mechanisms underlying the metabolic roles of hyperactive Rac1 remain less understood. Using pharmacological and molecular biological approaches, we now report mistargetting of biologically-active Rac1 [GTP-bound conformation] to the nuclear compartment in clonal INS-1 cells, normal rat islets and human islets under HG conditions. Our findings also suggest that such a signaling step is independent of post-translational prenylation of Rac1. Evidence is also presented to highlight novel roles for sustained activation of Rac1 in HG-induced expression of Cluster of Differentiation 36 [CD36], a fatty acid transporter protein, which is implicated in cell apoptosis. Finally, our findings suggest that metformin, a biguanide anti-diabetic drug, at a clinically relevant concentration, prevents β-cell defects [Rac1 activation, nuclear association, CD36 expression, stress kinase and caspase-3 activation, and loss in metabolic viability] under the duress of glucotoxicity. Potential implications of these findings in the context of novel and direct regulation of islet β-cell function by metformin are discussed.
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Magro-Checa, C; Beaart-van de Voorde, L J J; Middelkoop, H A M; Dane, M L; van der Wee, N J; van Buchem, M A; Huizinga, T W J; Steup-Beekman, G M
2017-04-01
Objective The objective of this study was to assess whether clinical and patient's reported outcomes are associated with a different pathophysiological origin of neuropsychiatric events presenting in systemic lupus erythematosus. Methods A total of 232 neuropsychiatric events presenting in 131 systemic lupus erythematosus patients were included. Neuropsychiatric systemic lupus erythematosus diagnosis was established per event by multidisciplinary evaluation. All neuropsychiatric events were divided according to a suspected underlying pathophysiological process into one of the following: non-neuropsychiatric systemic lupus erythematosus related, inflammatory and ischaemic neuropsychiatric systemic lupus erythematosus. The clinical outcome of all neuropsychiatric events was determined by a physician-completed four-point Likert scale. Health-related quality of life was measured with the subscales of the patient-generated Short Form 36 (SF-36) health survey questionnaire. The change between scores at paired visits of all domain scores, mental component summary (SF-36 MCS) and physical component summary (SF-36 PCS) scores were retrospectively calculated and used as patient-reported outcome. The association among these outcomes and the different origin of neuropsychiatric events was obtained using multiple logistic regression analysis. Results The clinical status of 26.8% non-neuropsychiatric systemic lupus erythematosus events, 15.8% ischaemic neuropsychiatric systemic lupus erythematosus and 51.6% inflammatory neuropsychiatric systemic lupus erythematosus improved after re-assessment. Almost all SF-36 domains had a positive change at re-assessment in all groups independently of the origin of neuropsychiatric events. Neuropsychiatric systemic lupus erythematosus ( B = 0.502; p < 0.001) and especially inflammatory neuropsychiatric systemic lupus erythematosus ( B = 0.827; p < 0.001) had better clinical outcome, with change in disease activity being the only important predictor. The change in SF-36 MCS was also independently associated with neuropsychiatric systemic lupus erythematosus ( B = 5.783; p < 0.05) and inflammatory neuropsychiatric systemic lupus erythematosus ( B = 11.133; p < 0.001). Disease duration and change in disease activity were the only predictors in both cases. The change in SF-36 PCS was only negatively associated with age. Conclusion Inflammatory neuropsychiatric systemic lupus erythematosus events have better clinical outcome and meaningful improvement in SF-36 MCS than ischaemic neuropsychiatric systemic lupus erythematosus or non-neuropsychiatric systemic lupus erythematosus.
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Aad, G; Abbott, B; Abdallah, J; Abdel Khalek, S; Abdinov, O; Aben, R; Abi, B; Abolins, M; AbouZeid, O S; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, B S; Adamczyk, L; Adams, D L; Adelman, J; Adomeit, S; Adye, T; Agatonovic-Jovin, T; Aguilar-Saavedra, J A; Agustoni, M; Ahlen, S P; Ahmadov, F; Aielli, G; Akerstedt, H; Åkesson, T P A; Akimoto, G; Akimov, A V; Alberghi, G L; Albert, J; Albrand, S; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexandre, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Allbrooke, B M M; Allison, L J; Allport, P P; Almond, J; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Alvarez Gonzalez, B; Alviggi, M G; Amako, K; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, G; Anderson, K J; Andreazza, A; Andrei, V; Anduaga, X S; Angelidakis, S; Angelozzi, I; Anger, P; 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Thompson, A S; Thomsen, L A; Thomson, E; Thomson, M; Thong, W M; Thun, R P; Tian, F; Tibbetts, M J; Tikhomirov, V O; Tikhonov, Yu A; Timoshenko, S; Tiouchichine, E; Tipton, P; Tisserant, S; Todorov, T; Todorova-Nova, S; Toggerson, B; Tojo, J; Tokár, S; Tokushuku, K; Tollefson, K; Tolley, E; Tomlinson, L; Tomoto, M; Tompkins, L; Toms, K; Topilin, N D; Torrence, E; Torres, H; Torró Pastor, E; Toth, J; Touchard, F; Tovey, D R; Tran, H L; Trefzger, T; Tremblet, L; Tricoli, A; Trigger, I M; Trincaz-Duvoid, S; Tripiana, M F; Trischuk, W; Trocmé, B; Troncon, C; Trottier-McDonald, M; Trovatelli, M; True, P; Trzebinski, M; Trzupek, A; Tsarouchas, C; Tseng, J C-L; Tsiareshka, P V; Tsionou, D; Tsipolitis, G; Tsirintanis, N; Tsiskaridze, S; Tsiskaridze, V; Tskhadadze, E G; Tsukerman, I I; Tsulaia, V; Tsuno, S; Tsybychev, D; Tudorache, A; Tudorache, V; Tuna, A N; Tupputi, S A; Turchikhin, S; Turecek, D; Turk Cakir, I; Turra, R; Tuts, P M; Tykhonov, A; Tylmad, M; Tyndel, M; Uchida, K; Ueda, I; Ueno, R; Ughetto, M; Ugland, M; Uhlenbrock, M; Ukegawa, F; Unal, G; Undrus, A; Unel, G; Ungaro, F C; Unno, Y; Unverdorben, C; Urbaniec, D; Urquijo, P; Usai, G; Usanova, A; Vacavant, L; Vacek, V; Vachon, B; Valencic, N; Valentinetti, S; Valero, A; Valery, L; Valkar, S; Valladolid Gallego, E; Vallecorsa, S; Valls Ferrer, J A; Van Den Wollenberg, W; Van Der Deijl, P C; van der Geer, R; van der Graaf, H; Van Der Leeuw, R; van der Ster, D; van Eldik, N; van Gemmeren, P; Van Nieuwkoop, J; van Vulpen, I; van Woerden, M C; Vanadia, M; Vandelli, W; Vanguri, R; Vaniachine, A; Vankov, P; Vannucci, F; Vardanyan, G; Vari, R; Varnes, E W; Varol, T; Varouchas, D; Vartapetian, A; Varvell, K E; Vazeille, F; Vazquez Schroeder, T; Veatch, J; Veloso, F; Veneziano, S; Ventura, A; Ventura, D; Venturi, M; Venturi, N; Venturini, A; Vercesi, V; Verducci, M; Verkerke, W; Vermeulen, J C; Vest, A; Vetterli, M C; Viazlo, O; Vichou, I; Vickey, T; Vickey Boeriu, O E; Viehhauser, G H A; Viel, S; Vigne, R; Villa, M; Villaplana Perez, M; Vilucchi, E; Vincter, M G; Vinogradov, V B; Virzi, J; Vivarelli, I; Vives Vaque, F; Vlachos, S; Vladoiu, D; Vlasak, M; Vogel, A; Vogel, M; Vokac, P; Volpi, G; Volpi, M; von der Schmitt, H; von Radziewski, H; von Toerne, E; Vorobel, V; Vorobev, K; Vos, M; Voss, R; Vossebeld, J H; Vranjes, N; Vranjes Milosavljevic, M; Vrba, V; Vreeswijk, M; Vu Anh, T; Vuillermet, R; Vukotic, I; Vykydal, Z; Wagner, P; Wagner, W; Wahlberg, H; Wahrmund, S; Wakabayashi, J; Walder, J; Walker, R; Walkowiak, W; Wall, R; Waller, P; Walsh, B; Wang, C; Wang, C; Wang, F; Wang, H; Wang, H; Wang, J; Wang, J; Wang, K; Wang, R; Wang, S M; Wang, T; Wang, X; Wanotayaroj, C; Warburton, A; Ward, C P; Wardrope, D R; Warsinsky, M; Washbrook, A; Wasicki, C; Watkins, P M; Watson, A T; Watson, I J; Watson, M F; Watts, G; Watts, S; Waugh, B M; Webb, S; Weber, M S; Weber, S W; Webster, J S; Weidberg, A R; Weigell, P; Weinert, B; Weingarten, J; Weiser, C; Weits, H; Wells, P S; Wenaus, T; Wendland, D; Weng, Z; Wengler, T; Wenig, S; Wermes, N; Werner, M; Werner, P; Wessels, M; Wetter, J; Whalen, K; White, A; White, M J; White, R; White, S; Whiteson, D; Wicke, D; Wickens, F J; Wiedenmann, W; Wielers, M; Wienemann, P; Wiglesworth, C; Wiik-Fuchs, L A M; Wijeratne, P A; Wildauer, A; Wildt, M A; Wilkens, H G; Will, J Z; Williams, H H; Williams, S; Willis, C; Willocq, S; Wilson, A; Wilson, J A; Wingerter-Seez, I; Winklmeier, F; Winter, B T; Wittgen, M; Wittig, T; Wittkowski, J; Wollstadt, S J; Wolter, M W; Wolters, H; Wosiek, B K; Wotschack, J; Woudstra, M J; Wozniak, K W; Wright, M; Wu, M; Wu, S L; Wu, X; Wu, Y; Wulf, E; Wyatt, T R; Wynne, B M; Xella, S; Xiao, M; Xu, D; Xu, L; Yabsley, B; Yacoob, S; Yakabe, R; Yamada, M; Yamaguchi, H; Yamaguchi, Y; Yamamoto, A; Yamamoto, K; Yamamoto, S; Yamamura, T; Yamanaka, T; Yamauchi, K; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, U K; Yang, Y; Yanush, S; Yao, L; Yao, W-M; Yasu, Y; Yatsenko, E; Yau Wong, K H; Ye, J; Ye, S; Yeletskikh, I; Yen, A L; Yildirim, E; Yilmaz, M; Yoosoofmiya, R; Yorita, K; Yoshida, R; Yoshihara, K; Young, C; Young, C J S; Youssef, S; Yu, D R; Yu, J; Yu, J M; Yu, J; Yuan, L; Yurkewicz, A; Yusuff, I; Zabinski, B; Zaidan, R; Zaitsev, A M; Zaman, A; Zambito, S; Zanello, L; Zanzi, D; Zeitnitz, C; Zeman, M; Zemla, A; Zengel, K; Zenin, O; Ženiš, T; Zerwas, D; Zevi Della Porta, G; Zhang, D; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, X; Zhang, Z; Zhao, Z; Zhemchugov, A; Zhong, J; Zhou, B; Zhou, L; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, N I; Zimmermann, C; Zimmermann, R; Zimmermann, S; Zimmermann, S; Zinonos, Z; Ziolkowski, M; Zobernig, G; Zoccoli, A; Zur Nedden, M; Zurzolo, G; Zutshi, V; Zwalinski, L
A measurement of charged-particle distributions sensitive to the properties of the underlying event is presented for an inclusive sample of events containing a [Formula: see text]-boson, decaying to an electron or muon pair. The measurement is based on data collected using the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of [Formula: see text] TeV with an integrated luminosity of [Formula: see text] fb[Formula: see text]. Distributions of the charged particle multiplicity and of the charged particle transverse momentum are measured in regions of azimuthal angle defined with respect to the [Formula: see text]-boson direction. The measured distributions are compared to similar distributions measured in jet events, and to the predictions of various Monte Carlo generators implementing different underlying event models.
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Aad, G.
2014-12-10
A measurement of charged-particle distributions sensitive to the properties of the underlying event is presented for an inclusive sample of events containing a \\(Z\\)-boson, decaying to an electron or muon pair. The measurement is based on data collected using the ATLAS detector at the LHC in proton–proton collisions at a centre-of-mass energy of \\(7\\) TeV with an integrated luminosity of \\(4.6\\) fb\\(^{-1}\\). Distributions of the charged particle multiplicity and of the charged particle transverse momentum are measured in regions of azimuthal angle defined with respect to the \\(Z\\)-boson direction. As a result, the measured distributions are compared to similar distributionsmore » measured in jet events, and to the predictions of various Monte Carlo generators implementing different underlying event models.« less
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Sleep deprivation affects reactivity to positive but not negative stimuli.
Pilcher, June J; Callan, Christina; Posey, J Laura
2015-12-01
The current study examined the effects of partial and total sleep deprivation on emotional reactivity. Twenty-eight partially sleep-deprived participants and 31 totally sleep-deprived participants rated their valence and arousal responses to positive and negative pictures across four testing sessions during the day following partial sleep deprivation or during the night under total sleep deprivation. The results suggest that valence and arousal ratings decreased under both sleep deprivation conditions. In addition, partial and total sleep deprivation had a greater negative effect on positive events than negative events. These results suggest that sleep-deprived persons are more likely to respond less to positive events than negative events. One explanation for the current findings is that negative events could elicit more attentive behavior and thus stable responding under sleep deprivation conditions. As such, sleep deprivation could impact reactivity to emotional stimuli through automated attentional and self-regulatory processes. Copyright © 2015 Elsevier Inc. All rights reserved.
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The Foggy EUV Corona and Coronal Heating by MHD Waves from Explosive Reconnection Events
NASA Technical Reports Server (NTRS)
Moore, Ron L.; Cirtain, Jonathan W.; Falconer, David A.
2008-01-01
In 0.5 arcsec/pixel TRACE coronal EUV images, the corona rooted in active regions that are at the limb and are not flaring is seen to consist of (1) a complex array of discrete loops and plumes embedded in (2) a diffuse ambient component that shows no fine structure and gradually fades with height. For each of two not-flaring active regions, found that the diffuse component is (1) approximately isothermal and hydrostatic and (2) emits well over half of the total EUV luminosity of the active-region corona. Here, from a TRACE Fe XII coronal image of another not-flaring active region, the large sunspot active region AR 10652 when it was at the west limb on 30 July 2004, we separate the diffuse component from the discrete loop component by spatial filtering, and find that the diffuse component has about 60% of the total luminosity. If under much higher spatial resolution than that of TRACE (e. g., the 0.1 arcsec/pixel resolution of the Hi-C sounding-rocket experiment proposed by J. W. Cirtain et al), most of the diffuse component remains diffuse rather being resolved into very narrow loops and plumes, this will raise the possibility that the EUV corona in active regions consists of two basically different but comparably luminous components: one being the set of discrete bright loops and plumes and the other being a truly diffuse component filling the space between the discrete loops and plumes. This dichotomy would imply that there are two different but comparably powerful coronal heating mechanisms operating in active regions, one for the distinct loops and plumes and another for the diffuse component. We present a scenario in which (1) each discrete bright loop or plume is a flux tube that was recently reconnected in a burst of reconnection, and (2) the diffuse component is heated by MHD waves that are generated by these reconnection events and by other fine-scale explosive reconnection events, most of which occur in and below the base of the corona where they are seen as UV explosive events, EUV blinkers, and type II spicules. These MHD waves propagate across field lines and dissipate, heating the plasma in the field between the bright loops and plumes.
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Interpreting Reservoir Microseismicity Detected During CO2 Injection at the Aneth Oil Field
NASA Astrophysics Data System (ADS)
Rutledge, J. T.
2009-12-01
Microseismic monitoring is expected to be a useful tool in CO2 sequestration projects for mapping pressure fronts and detecting fault activation and potential leakage paths. Downhole microseismic monitoring and several other techniques are being tested for their efficacy in tracking movement and containment of CO2 injected at the Aneth oil field located in San Juan County, Utah. The Southwest Regional Partnership on CO2 Sequestration is conducting the monitoring activities in collaboration with Resolute Natural Resources Company, under the support of the U.S. Department of Energy’s National Energy Technology Laboratory. The CO2 injection at Aneth is associated with a field-wide enhanced oil recovery operation following decades of pressure maintenance and oil recovery by water-flood injection. A 60-level geophone string was cemented into a monitoring well equipped with both 3-component and vertical component geophones spanning from 800 to 1700 m depth. The top of the oil reservoir in the study area is at approximately 1730 m depth. Over the first year of monitoring, approximately 3800 microearthquakes have been detected within about 3 km of the geophone string. The Aneth reservoir events are relatively large with magnitudes ranging from approximately -1 to 1. For comparison, reservoir seismicity induced during hydraulic fracturing treatments typically result in events with magnitudes <-1, unless pre-existing faults are pressurized by the treatments. The Aneth events delineate two NW-SE oriented fracture zones located on opposite flanks of the reservoir. Injection activity is fairly uniform over the entire field area, and the microseismicity does not correlate either temporally or spatially with any anomalous changes in injection or production activities near the source locations. Because the activity is fairly isolated and relatively energetic, I speculate that the seismicity may be due to critically stressed structures driven by longer-term production- and/or injection-induced stress changes. Ongoing analysis includes extracting precise arrival time to improve relative source locations and looking for correlations of event occurrence and moment release with field-wide rates of injection and production.
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Han, Xu; Kim, Jung-jae; Kwoh, Chee Keong
2016-01-01
Biomedical text mining may target various kinds of valuable information embedded in the literature, but a critical obstacle to the extension of the mining targets is the cost of manual construction of labeled data, which are required for state-of-the-art supervised learning systems. Active learning is to choose the most informative documents for the supervised learning in order to reduce the amount of required manual annotations. Previous works of active learning, however, focused on the tasks of entity recognition and protein-protein interactions, but not on event extraction tasks for multiple event types. They also did not consider the evidence of event participants, which might be a clue for the presence of events in unlabeled documents. Moreover, the confidence scores of events produced by event extraction systems are not reliable for ranking documents in terms of informativity for supervised learning. We here propose a novel committee-based active learning method that supports multi-event extraction tasks and employs a new statistical method for informativity estimation instead of using the confidence scores from event extraction systems. Our method is based on a committee of two systems as follows: We first employ an event extraction system to filter potential false negatives among unlabeled documents, from which the system does not extract any event. We then develop a statistical method to rank the potential false negatives of unlabeled documents 1) by using a language model that measures the probabilities of the expression of multiple events in documents and 2) by using a named entity recognition system that locates the named entities that can be event arguments (e.g. proteins). The proposed method further deals with unknown words in test data by using word similarity measures. We also apply our active learning method for the task of named entity recognition. We evaluate the proposed method against the BioNLP Shared Tasks datasets, and show that our method can achieve better performance than such previous methods as entropy and Gibbs error based methods and a conventional committee-based method. We also show that the incorporation of named entity recognition into the active learning for event extraction and the unknown word handling further improve the active learning method. In addition, the adaptation of the active learning method into named entity recognition tasks also improves the document selection for manual annotation of named entities.
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On the deep-mantle origin of the Deccan Traps
NASA Astrophysics Data System (ADS)
Glišović, Petar; Forte, Alessandro M.
2017-02-01
The Deccan Traps in west-central India constitute one of Earth’s largest continental flood basalt provinces, whose eruption played a role in the Cretaceous-Paleogene extinction event. The unknown mantle structure under the Indian Ocean at the start of the Cenozoic presents a challenge for connecting the event to a deep mantle origin. We used a back-and-forth iterative method for time-reversed convection modeling, which incorporates tomography-based, present-day mantle heterogeneity to reconstruct mantle structure at the start of the Cenozoic. We show a very low-density, deep-seated upwelling that ascends beneath the Réunion hot spot at the time of the Deccan eruptions. We found a second active upwelling below the Comores hot spot that likely contributed to the region of partial melt feeding the massive eruption.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-30
... options on certain indexes measuring the relative performance of one reference security or reference index... one underlying stock and one underlying ETF, which are also traded on the Phlx.\\5\\ An Alpha Index is...-settled, European-style options. In the event of a corporate event that eliminates one of the underlying...
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Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus
Vielmuth, Franziska; Walter, Elias; Fuchs, Michael; Radeva, Mariya Y.; Buechau, Fanny; Magin, Thomas M.; Spindler, Volker; Waschke, Jens
2018-01-01
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly caused by autoantibodies against desmoglein (Dsg) 1 and 3. Keratin alterations are a structural hallmark in pemphigus pathogenesis and correlate with loss of intercellular adhesion. However, the significance for autoantibody-induced loss of intercellular adhesion is largely unknown. In wild-type (wt) murine keratinocytes, pemphigus autoantibodies induced keratin filament retraction. Under the same conditions, we used murine keratinocytes lacking all keratin filaments (KtyII k.o.) as a model system to dissect the role of keratins in pemphigus. KtyII k.o. cells show compromised intercellular adhesion without antibody (Ab) treatment, which was not impaired further by pathogenic pemphigus autoantibodies. Nevertheless, direct activation of p38MAPK via anisomycin further decreased intercellular adhesion indicating that cell cohesion was not completely abrogated in the absence of keratins. Direct inhibition of Dsg3, but not of Dsg1, interaction via pathogenic autoantibodies as revealed by atomic force microscopy was detectable in both cell lines demonstrating that keratins are not required for this phenomenon. However, PF-IgG shifted Dsg1-binding events from cell borders toward the free cell surface in wt cells. This led to a distribution pattern of Dsg1-binding events similar to KtyII k.o. cells under resting conditions. In keratin-deficient keratinocytes, PF-IgG impaired Dsg1-binding strength, which was not different from wt cells under resting conditions. In addition, pathogenic autoantibodies were capable of activating p38MAPK in both KtyII wt and k.o. cells, the latter of which already displayed robust p38MAPK activation under resting conditions. Since inhibition of p38MAPK blocked autoantibody-induced loss of intercellular adhesion in wt cells and restored baseline cell cohesion in keratin-deficient cells, we conclude that p38MAPK signaling is (i) critical for regulation of cell adhesion, (ii) regulated by keratins, and (iii) targets both keratin-dependent and -independent mechanisms. PMID:29616033
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Hall, Stephen P.; Traub, Roger D.; Adams, Natalie E.; Cunningham, Mark O.; Schofield, Ian; Jenkins, Alistair J.
2018-01-01
Acute in vitro models have revealed a great deal of information about mechanisms underlying many types of epileptiform activity. However, few examples exist that shed light on spike-and-wave (SpW) patterns of pathological activity. SpW are seen in many epilepsy syndromes, both generalized and focal, and manifest across the entire age spectrum. They are heterogeneous in terms of their severity, symptom burden, and apparent anatomical origin (thalamic, neocortical, or both), but any relationship between this heterogeneity and underlying pathology remains elusive. In this study we demonstrate that physiological delta-frequency rhythms act as an effective substrate to permit modeling of SpW of cortical origin and may help to address this issue. For a starting point of delta activity, multiple subtypes of SpW could be modeled computationally and experimentally by either enhancing the magnitude of excitatory synaptic events ascending from neocortical layer 5 to layers 2/3 or selectively modifying superficial layer GABAergic inhibition. The former generated SpW containing multiple field spikes with long interspike intervals, whereas the latter generated SpW with short-interval multiple field spikes. Both types had different laminar origins and each disrupted interlaminar cortical dynamics in a different manner. A small number of examples of human recordings from patients with different diagnoses revealed SpW subtypes with the same temporal signatures, suggesting that detailed quantification of the pattern of spikes in SpW discharges may be a useful indicator of disparate underlying epileptogenic pathologies. NEW & NOTEWORTHY Spike-and-wave-type discharges (SpW) are a common feature in many epilepsies. Their electrographic manifestation is highly varied, as are available genetic clues to associated underlying pathology. Using computational and in vitro models, we demonstrate that distinct subtypes of SpW are generated by lamina-selective disinhibition or enhanced interlaminar excitation. These subtypes could be detected in at least some noninvasive patient recordings, suggesting more detailed analysis of SpW may be useful in determining clinical pathology. PMID:28954894
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Hall, Stephen P; Traub, Roger D; Adams, Natalie E; Cunningham, Mark O; Schofield, Ian; Jenkins, Alistair J; Whittington, Miles A
2018-01-01
Acute in vitro models have revealed a great deal of information about mechanisms underlying many types of epileptiform activity. However, few examples exist that shed light on spike-and-wave (SpW) patterns of pathological activity. SpW are seen in many epilepsy syndromes, both generalized and focal, and manifest across the entire age spectrum. They are heterogeneous in terms of their severity, symptom burden, and apparent anatomical origin (thalamic, neocortical, or both), but any relationship between this heterogeneity and underlying pathology remains elusive. In this study we demonstrate that physiological delta-frequency rhythms act as an effective substrate to permit modeling of SpW of cortical origin and may help to address this issue. For a starting point of delta activity, multiple subtypes of SpW could be modeled computationally and experimentally by either enhancing the magnitude of excitatory synaptic events ascending from neocortical layer 5 to layers 2/3 or selectively modifying superficial layer GABAergic inhibition. The former generated SpW containing multiple field spikes with long interspike intervals, whereas the latter generated SpW with short-interval multiple field spikes. Both types had different laminar origins and each disrupted interlaminar cortical dynamics in a different manner. A small number of examples of human recordings from patients with different diagnoses revealed SpW subtypes with the same temporal signatures, suggesting that detailed quantification of the pattern of spikes in SpW discharges may be a useful indicator of disparate underlying epileptogenic pathologies. NEW & NOTEWORTHY Spike-and-wave-type discharges (SpW) are a common feature in many epilepsies. Their electrographic manifestation is highly varied, as are available genetic clues to associated underlying pathology. Using computational and in vitro models, we demonstrate that distinct subtypes of SpW are generated by lamina-selective disinhibition or enhanced interlaminar excitation. These subtypes could be detected in at least some noninvasive patient recordings, suggesting more detailed analysis of SpW may be useful in determining clinical pathology.
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Metusalem, Ross; Kutas, Marta; Urbach, Thomas P.; Elman, Jeffrey L.
2016-01-01
During incremental language comprehension, the brain activates knowledge of described events, including knowledge elements that constitute semantic anomalies in their linguistic context. The present study investigates hemispheric asymmetries in this process, with the aim of advancing our understanding of the neural basis and functional properties of event knowledge activation during incremental comprehension. In a visual half-field event-related brain potential (ERP) experiment, participants read brief discourses in which the third sentence contained a word that was either highly expected, semantically anomalous but related to the described event, or semantically anomalous but unrelated to the described event. For both visual fields of target word presentation, semantically anomalous words elicited N400 ERP components of greater amplitude than did expected words. Crucially, event-related anomalous words elicited a reduced N400 relative to event-unrelated anomalous words only with left visual field/right hemisphere presentation. This result suggests that right hemisphere processes are critical to the activation of event knowledge elements that violate the linguistic context, and in doing so informs existing theories of hemispheric asymmetries in semantic processing during language comprehension. Additionally, this finding coincides with past research suggesting a crucial role for the right hemisphere in elaborative inference generation, raises interesting questions regarding hemispheric coordination in generating event-specific linguistic expectancies, and more generally highlights the possibility of functional dissociation between event knowledge activation for the generation of elaborative inferences and for linguistic expectancies. PMID:26878980
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29 CFR 4043.32 - Transfer of benefit liabilities.
Code of Federal Regulations, 2011 CFR
2011-07-01
... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...
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29 CFR 4043.32 - Transfer of benefit liabilities.
Code of Federal Regulations, 2012 CFR
2012-07-01
... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...
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29 CFR 4043.32 - Transfer of benefit liabilities.
Code of Federal Regulations, 2014 CFR
2014-07-01
... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...
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29 CFR 4043.32 - Transfer of benefit liabilities.
Code of Federal Regulations, 2010 CFR
2010-07-01
... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...
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29 CFR 4043.32 - Transfer of benefit liabilities.
Code of Federal Regulations, 2013 CFR
2013-07-01
... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...
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Runoff generation through ephemeral streams in south-east Italy
NASA Astrophysics Data System (ADS)
Doglioni, A.; Simeone, V.; Giustolisi, O.
2012-04-01
Ephemeral streams are morphological elements, typical of karst areas, characterized by relatively large and flat bottom transects (Camarasa & Tilford, 2002). These occasionally drain runoff generated by extreme rainfall events, characterized by high return periods. The activation of these streams was investigated by several authors for the Mediterranean regions, and in particular for south Spain and north Africa (Camarasa & Segura, 2001; De Vera, 1984). However, there are few analyses for karst areas of south-east of Italy (Cotecchia, 2006; Polemio, 2010). South-east of Italy, in particular the central part of Apulia, is characterized by a karst morphology, with a moderately elevated plateau, namely Murgia, which is drained by a network of ephemeral streams. These are normally dry, relatively short-length and straights, and their main outlets are on the coast. They normally drain water after extraordinary rainfall events, which can generate very high discharges, which can potentially flood the areas close to the streams. For this reason, the definition of an activation threshold for ephemeral streams is a paramount problem, even if this constitutes a complex problem, since the dynamics of the catchment drained by these streams in highly non-linear and biased by multiple variables (e.g. urbanization, land use, etc.). The main problem affecting the analysis and prediction of flood events in karst semi-arid regions is the almost complete absence of discharge time-series, measured at the outlets of the ephemeral streams. This prevents from the identification of accurate statistics of flood events and on the determination of rainfall events, which may potentially generate floods. Indeed, floods and in general flash floods are relatively rare events for semi-arid karst regions, however they can be really severe and disruptive, causing serious damages to people and infrastructures. This work presents an analysis of the ephemeral stream activation in karst semi-arid areas, in a partially urbanized catchment located in Apulia (south east of Italy). The analysis is based on full 2D simulation of the behaviour of a network of ephemeral streams. A full 2D approach integrates the hydrological and hydraulic models, in order to account first for the dynamic of catchment response to rainfall and activation of the streams, and then for the hydraulic behaviour of the streams. This analysis entails the simulation of extreme events corresponding to low, medium and high return periods, in order to identify which event presumably activate the ephemeral streams. Camarasa, A.M. and Tilford, K.A. (2002). "Rainfall-runoff modelling of ephemeral streams in the Valencia region (eastern Spain)". Hydrological Processes, 16: 3329-3344. Camarasa Belmonte, A.M, and Segura Beltran, F. (2001). "Flood events in Mediterranean ephemeral stream (ramblas) in Valencia Region, Spain". Catena, 45: 229-249. Cotecchia, V. (2006). "Il disordine idraulico evidenziato in Bari dall'evento pluviometrico dell'Ottobre 2005 e il caso dell' ex cava di Maso". Continuità - Rassegna Tecnica Pugliese, 1-2.2006: 25-76. De Vera M. (1984). "Rainfall-Runoff relationship of some catchments with karstic geomorphology under arid to semi-arid conditions". Journal of Hydrology, 68(1-4): 85-93. Polemio, M., (2010). "Historical floods and a recent extreme rainfall event in the Murgia karstic environment (Southern Italy)". Zeitschrift für Geomorphologie, 54(2): 195-219.
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Rewiring of auxin signaling under persistent shade.
Pucciariello, Ornella; Legris, Martina; Costigliolo Rojas, Cecilia; Iglesias, María José; Hernando, Carlos Esteban; Dezar, Carlos; Vazquez, Martín; Yanovsky, Marcelo J; Finlayson, Scott A; Prat, Salomé; Casal, Jorge J
2018-05-22
Light cues from neighboring vegetation rapidly initiate plant shade-avoidance responses. Despite our detailed knowledge of the early steps of this response, the molecular events under prolonged shade are largely unclear. Here we show that persistent neighbor cues reinforce growth responses in addition to promoting auxin-responsive gene expression in Arabidopsis and soybean. However, while the elevation of auxin levels is well established as an early event, in Arabidopsis , the response to prolonged shade occurs when auxin levels have declined to the prestimulation values. Remarkably, the sustained low activity of phytochrome B under prolonged shade led to ( i ) decreased levels of PHYTOCHROME INTERACTING FACTOR 4 (PIF4) in the cotyledons (the organs that supply auxin) along with increased levels in the vascular tissues of the stem, ( ii ) elevated expression of the PIF4 targets INDOLE-3-ACETIC ACID 19 ( IAA19 ) and IAA29 , which in turn reduced the expression of the growth-repressive IAA17 regulator, ( iii ) reduced abundance of AUXIN RESPONSE FACTOR 6, ( iv ) reduced expression of MIR393 and increased abundance of its targets, the auxin receptors, and ( v ) elevated auxin signaling as indicated by molecular markers. Mathematical and genetic analyses support the physiological role of this system-level rearrangement. We propose that prolonged shade rewires the connectivity between light and auxin signaling to sustain shade avoidance without enhanced auxin levels.
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Real-Time Analysis of Magnetic Hyperthermia Experiments on Living Cells under a Confocal Microscope.
Connord, Vincent; Clerc, Pascal; Hallali, Nicolas; El Hajj Diab, Darine; Fourmy, Daniel; Gigoux, Véronique; Carrey, Julian
2015-05-01
Combining high-frequency alternating magnetic fields (AMF) and magnetic nanoparticles (MNPs) is an efficient way to induce biological responses through several approaches: magnetic hyperthermia, drug release, controls of gene expression and neurons, or activation of chemical reactions. So far, these experiments cannot be analyzed in real-time during the AMF application. A miniaturized electromagnet fitting under a confocal microscope is built, which produces an AMF of frequency and amplitude similar to the ones used in magnetic hyperthermia. AMF application induces massive damages to tumoral cells having incorporated nanoparticles into their lysosomes without affecting the others. Using this setup, real-time analyses of molecular events occurring during AMF application are performed. Lysosome membrane permeabilization and reactive oxygen species production are detected after only 30 min of AMF application, demonstrating they occur at an early stage in the cascade of events leading eventually to cell death. Additionally, lysosomes self-assembling into needle-shaped organization under the influence of AMF is observed in real-time. This experimental approach will permit to get a deeper insight into the physical, molecular, and biological process occurring in several innovative techniques used in nanomedecine based on the combined use of MNPs and high-frequency magnetic fields. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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NASA Astrophysics Data System (ADS)
Wang, Weiqin; Chen, Qian; Hussain, Saddam; Mei, Junhao; Dong, Huanglin; Peng, Shaobing; Huang, Jianliang; Cui, Kehui; Nie, Lixiao
2016-01-01
Double direct-seeding for double rice cropping is a simplified, labor saving, and efficient cropping system to improve multiple-crop index and total rice production in central China. However, poor crop establishment of direct-seeded early rice due to chilling stress is the main obstacle to wide spread of this system. A series of experiments were conducted to unravel the effects of pre-sowing seed treatments on emergence, seedling growth and associated metabolic events of direct-seeded early rice under chilling stress. Two seed priming treatments and two seed coating treatments were used in all the experiments. A non-treated control treatment was also maintained for comparison. In both the field and growth chamber studies, seed priming with selenium or salicylic acid significantly enhanced the emergence and seedling growth of rice compared with non-treated control. Nevertheless, such positive effects were not apparent for seed coating treatments. Better emergence and vigorous seedling growth of rice after seed priming was associated with enhanced α-amylase activity, higher soluble sugars contents, and greater respiration rate in primed rice seedlings under chilling stress. Taking together, these findings may provide new avenues for understanding and advancing priming-induced chilling tolerance in direct-seeded early rice in double rice cropping system.
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Differential Go/NoGo Activity in Both Contingent Negative Variation and Spectral Power
Funderud, Ingrid; Lindgren, Magnus; Løvstad, Marianne; Endestad, Tor; Voytek, Bradley; Knight, Robert T.; Solbakk, Anne-Kristin
2012-01-01
We investigated whether both the contingent negative variation (CNV), an event-related potential index of preparatory brain activity, and event-related oscillatory EEG activity differentiated Go and NoGo trials in a delayed response task. CNV and spectral power (4–100 Hz) were calculated from EEG activity in the preparatory interval in 16 healthy adult participants. As previously reported, CNV amplitudes were higher in Go compared to NoGo trials. In addition, event-related spectral power of the Go condition was reduced in the theta to low gamma range compared to the NoGo condition, confirming that preparing to respond is associated with modulation of event-related spectral activity as well as the CNV. Altogether, the impact of the experimental manipulation on both slow event-related potentials and oscillatory EEG activity may reflect coordinated dynamic changes in the excitability of distributed neural networks involved in preparation. PMID:23119040
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Subsampling effects in neuronal avalanche distributions recorded in vivo
Priesemann, Viola; Munk, Matthias HJ; Wibral, Michael
2009-01-01
Background Many systems in nature are characterized by complex behaviour where large cascades of events, or avalanches, unpredictably alternate with periods of little activity. Snow avalanches are an example. Often the size distribution f(s) of a system's avalanches follows a power law, and the branching parameter sigma, the average number of events triggered by a single preceding event, is unity. A power law for f(s), and sigma = 1, are hallmark features of self-organized critical (SOC) systems, and both have been found for neuronal activity in vitro. Therefore, and since SOC systems and neuronal activity both show large variability, long-term stability and memory capabilities, SOC has been proposed to govern neuronal dynamics in vivo. Testing this hypothesis is difficult because neuronal activity is spatially or temporally subsampled, while theories of SOC systems assume full sampling. To close this gap, we investigated how subsampling affects f(s) and sigma by imposing subsampling on three different SOC models. We then compared f(s) and sigma of the subsampled models with those of multielectrode local field potential (LFP) activity recorded in three macaque monkeys performing a short term memory task. Results Neither the LFP nor the subsampled SOC models showed a power law for f(s). Both, f(s) and sigma, depended sensitively on the subsampling geometry and the dynamics of the model. Only one of the SOC models, the Abelian Sandpile Model, exhibited f(s) and sigma similar to those calculated from LFP activity. Conclusion Since subsampling can prevent the observation of the characteristic power law and sigma in SOC systems, misclassifications of critical systems as sub- or supercritical are possible. Nevertheless, the system specific scaling of f(s) and sigma under subsampling conditions may prove useful to select physiologically motivated models of brain function. Models that better reproduce f(s) and sigma calculated from the physiological recordings may be selected over alternatives. PMID:19400967
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Duarte, João V; Pereira, João M S; Quendera, Bruno; Raimundo, Miguel; Moreno, Carolina; Gomes, Leonor; Carrilho, Francisco; Castelo-Branco, Miguel
2015-10-01
Type 2 diabetes (T2DM) patients develop vascular complications and have increased risk for neurophysiological impairment. Vascular pathophysiology may alter the blood flow regulation in cerebral microvasculature, affecting neurovascular coupling. Reduced fMRI signal can result from decreased neuronal activation or disrupted neurovascular coupling. The uncertainty about pathophysiological mechanisms (neurodegenerative, vascular, or both) underlying brain function impairments remains. In this cross-sectional study, we investigated if the hemodynamic response function (HRF) in lesion-free brains of patients is altered by measuring BOLD (Blood Oxygenation Level-Dependent) response to visual motion stimuli. We used a standard block design to examine the BOLD response and an event-related deconvolution approach. Importantly, the latter allowed for the first time to directly extract the true shape of HRF without any assumption and probe neurovascular coupling, using performance-matched stimuli. We discovered a change in HRF in early stages of diabetes. T2DM patients show significantly different fMRI response profiles. Our visual paradigm therefore demonstrated impaired neurovascular coupling in intact brain tissue. This implies that functional studies in T2DM require the definition of HRF, only achievable with deconvolution in event-related experiments. Further investigation of the mechanisms underlying impaired neurovascular coupling is needed to understand and potentially prevent the progression of brain function decrements in diabetes.
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Nath, Debashis; Chen, Wen; Graf, Hans-F; Lan, Xiaoqiang; Gong, Hainan
2017-09-20
Upper tropospheric equatorial westerly ducts over the Pacific Ocean are the preferred location for Rossby wave breaking events during boreal winter and spring. These subtropical wave breaking events lead to the intrusion of high PV (potential vorticity) air along the extra-tropical tropopause and transport ozone rich dry stratospheric air into the tropics. The intrusion frequency has strong interannual variability due to ENSO (El-Niño/Southern Oscillation), with more events under La-Niña and less under El-Niño conditions. This may result from stronger equatorial westerly ducts and subtropical jets during La-Niña and weaker during El-Niño. It was previously suggested that the interannual variability of the tropospheric ozone distribution over the central-eastern Pacific Ocean is mainly driven by convective activity related to ENSO and that the barotropic nature of the subtropical intrusions restricts the tracers within the UT. However, our analysis shows that tropospheric ozone concentration and subtropical intrusions account ~65% of the co- variability (below 5 km) in the outer tropical (10-25°N) central Pacific Ocean, particularly during La-Niña conditions. Additionally, we find a two-fold increase and westward shift in the intrusion frequency over the Pacific Ocean, due to the climate regime shift in SST pattern during 1997/98.
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Saxton, Matthew A.; Arnold, Robert J.; Bourbonniere, Richard A.; McKay, Robert Michael L.; Wilhelm, Steven W.
2011-01-01
Blooms of the potentially toxic cyanobacterium Microcystis are common events globally, and as a result significant resources continue to be dedicated to monitoring and controlling these events. Recent studies have shown that a significant proportion of total cell-associated phosphorus (P) in marine phytoplankton can be surface adsorbed; as a result studies completed to date do not accurately report the P demands of these organisms. In this study we measure the total cell-associated and intracellular P as well as growth rates of two toxic strains of Microcystis aeruginosa Kütz grown under a range of P concentrations. The results show that the intracellular P pool in Microcystis represents a percentage of total cell-associated P (50–90%) similar to what has been reported for actively growing algae in marine systems. Intracellular P concentrations (39–147 fg cell−1) generally increased with increasing P concentrations in the growth medium, but growth rate and the ratio of total cell-associated to intracellular P remained generally stable. Intracellular P quotas and growth rates in cells grown under the different P treatments illustrate the ability of this organism to successfully respond to changes in ambient P loads, and thus have implications for ecosystem scale productivity models employing P concentrations to predict algal bloom events. PMID:22279445
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Li, Yue; Zhang, Lei; Long, Kehong; Gong, Hui; Lei, Hao
2018-02-16
A growing body of literature has suggested that video game playing can induce functional and structural plasticity of the brain. The underlying mechanisms, however, remain poorly understood. In this study, functional near-infrared spectroscopy (fNIRS) was used to record prefrontal activities in 24 experienced game players when they played a massively multiplayer online battle arena video game, League of Legends (LOL), under naturalistic conditions. It was observed that game onset was associated with significant activations in the ventrolateral prefrontal cortex (VLPFC) and concomitant deactivations in the dorsolateral prefrontal cortex (DLPFC) and frontal pole area (FPA). Game events, such as slaying an enemy and being slain by an enemy evoked region-specific time-locked hemodynamic/oxygenation responses in the prefrontal cortex (PFC). It was proposed that the VLPFC activities during LOL playing are likely responses to visuo-motor task load of the game, while the DLPFC/FPA activities may be involved in the constant shifts of attentional states and allocation of cognitive resources required by game playing. The present study demonstrated that it is feasible to use fNIRS to monitor real-time prefrontal activity during online video game playing. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Sex Differences in the Neural Correlates of Specific and General Autobiographical Memory
Compère, Laurie; Sperduti, Marco; Gallarda, Thierry; Anssens, Adèle; Lion, Stéphanie; Delhommeau, Marion; Martinelli, Pénélope; Devauchelle, Anne-Dominique; Oppenheim, Catherine; Piolino, Pascale
2016-01-01
Autobiographical memory (AM) underlies the formation and temporal continuity over time of personal identity. The few studies on sex-related differences in AM suggest that men and women adopt different cognitive or emotional strategies when retrieving AMs. However, none of the previous works has taken into account the distinction between episodic autobiographical memory (EAM), consisting in the retrieval of specific events by means of mental time travel, and semantic autobiographical memory (SAM), which stores general personal events. Thus, it remains unclear whether differences in these strategies depend on the nature of the memory content to be retrieved. In the present study we employed functional MRI to examine brain activity underlying potential sex differences in EAM and SAM retrieval focusing on the differences in strategies related to the emotional aspects of memories while controlling for basic cognitive strategies. On the behavioral level, there was no significant sex difference in memory performances or subjective feature ratings of either type of AM. Activations common to men and women during AM retrieval were observed in a typical bilateral network comprising medial and lateral temporal regions, precuneus, occipital cortex as well as prefrontal cortex. Contrast analyses revealed that there was no difference between men and women in the EAM condition. In the SAM condition, women showed an increased activity, compared to men, in the dorsal anterior cingulate cortex, inferior parietal and precentral gyrus. Overall, these findings suggest that differential neural activations reflect sex-specific strategies related to emotional aspects of AMs, particularly regarding SAM. We propose that this pattern of activation during SAM retrieval reflects the cognitive cost linked to emotion regulation strategies recruited by women compared to men. These sex-related differences have interesting implications for understanding psychiatric disorders with differential sex prevalence and in which one of key features is overgenerality in AM. PMID:27378884
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Xu, Xiuduan; Wang, Hongli; Liu, Shasha; Xing, Chen; Liu, Yang; Aodengqimuge; Zhou, Wei; Yuan, Xiaoyan; Ma, Yongfu; Hu, Meiru; Hu, Yongliang; Zou, Shuxian; Gu, Ye; Peng, Shuangqing; Yuan, Shengtao; Li, Weiping; Ma, Yuanfang; Song, Lun
2016-10-02
ABSTARCT Epidemiological and clinical studies have increasingly shown that fine particulate matter (PM2.5) is associated with a number of pathological respiratory diseases, such as bronchitis, asthma, and chronic obstructive pulmonary disease, which share the common feature of airway inflammation induced by particle exposure. Thus, understanding how PM2.5 triggers inflammatory responses in the respiratory system is crucial for the study of PM2.5 toxicity. In the current study, we found that exposing human bronchial epithelial cells (immortalized Beas-2B cells and primary cells) to PM2.5 collected in the winter in Wuhan, a city in southern China, induced a significant upregulation of VEGFA (vascular endothelial growth factor A) production, a signaling event that typically functions to control chronic airway inflammation and vascular remodeling. Further investigations showed that macroautophagy/autophagy was induced upon PM2.5 exposure and then mediated VEGFA upregulation by activating the SRC (SRC proto-oncogene, non-receptor tyrosine kinase)-STAT3 (signal transducer and activator of transcription 3) pathway in bronchial epithelial cells. By exploring the upstream signaling events responsible for autophagy induction, we revealed a requirement for TP53 (tumor protein p53) activation and the expression of its downstream target DRAM1 (DNA damage regulated autophagy modulator 1) for the induction of autophagy. These results thus extend the role of TP53-DRAM1-dependent autophagy beyond cell fate determination under genotoxic stress and to the control of proinflammatory cytokine production. Moreover, PM2.5 exposure strongly induced the activation of the ATR (ATR serine/threonine kinase)-CHEK1/CHK1 (checkpoint kinase 1) axis, which subsequently triggered TP53-dependent autophagy and VEGFA production in Beas-2B cells. Therefore, these findings suggest a novel link between processes regulating genomic integrity and airway inflammation via autophagy induction in bronchial epithelial cells under PM2.5 exposure.
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Moustapha, A; Pérétout, PA; Rainey, NE; Sureau, F; Geze, M; Petit, J-M; Dewailly, E; Slomianny, C; Petit, PX
2015-01-01
Curcumin, a major active component of turmeric (Curcuma longa, L.), has anticancer effects. In vitro studies suggest that curcumin inhibits cancer cell growth by activating apoptosis, but the mechanism underlying these effects is still unclear. Here, we investigated the mechanisms leading to apoptosis in curcumin-treated cells. Curcumin induced endoplasmic reticulum stress causing calcium release, with a destabilization of the mitochondrial compartment resulting in apoptosis. These events were also associated with lysosomal membrane permeabilization and of caspase-8 activation, mediated by cathepsins and calpains, leading to Bid cleavage. Truncated tBid disrupts mitochondrial homeostasis and enhance apoptosis. We followed the induction of autophagy, marked by the formation of autophagosomes, by staining with acridine orange in cells exposed curcumin. At this concentration, only the early events of apoptosis (initial mitochondrial destabilization with any other manifestations) were detectable. Western blotting demonstrated the conversion of LC3-I to LC3-II (light chain 3), a marker of active autophagosome formation. We also found that the production of reactive oxygen species and formation of autophagosomes following curcumin treatment was almost completely blocked by N-acetylcystein, the mitochondrial specific antioxidants MitoQ10 and SKQ1, the calcium chelators, EGTA-AM or BAPTA-AM, and the mitochondrial calcium uniporter inhibitor, ruthenium red. Curcumin-induced autophagy failed to rescue all cells and most cells underwent type II cell death following the initial autophagic processes. All together, these data imply a fail-secure mechanism regulated by autophagy in the action of curcumin, suggesting a therapeutic potential for curcumin. Offering a novel and effective strategy for the treatment of malignant cells. PMID:27551451